LOCUS 014_IIG_Bs10_SNP 3795510 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1db-cvskbt5 VERSION urn.local...1db-cvskbt5 KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3795400..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..399834) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399520..399539 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399521 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="upshifts" CDS 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" /label="yclG CDS" gene 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /label="yclG gene" promotor_-10 complement(399831..399849) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399844) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399865..399870) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401305 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" /label="yczF CDS" gene complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /label="yczF gene" promotor_-10 complement(401570..401581) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401572) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401596..401602) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 401617..401623 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 401637..401648 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401650 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="upshifts" CDS 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" /label="gerKA CDS" gene 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /label="gerKA gene" CDS 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" /label="gerKC CDS" gene 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /label="gerKC gene" CDS 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" /label="gerKB CDS" gene 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /label="gerKB gene" downshifts 405654 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" /label="downshifts" CDS complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" /label="yclH CDS" gene complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /label="yclH gene" CDS complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" /label="yclI CDS" gene complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /label="yclI gene" misc_feature 408101..408120 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408104 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" /label="yclJ CDS" gene 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /label="yclJ gene" CDS 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" /label="yclK CDS" gene 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /label="yclK gene" downshifts 410211 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" /label="downshifts" S_feature 410256..410360 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410350..410369 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410362 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(410394) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" /label="downshifts" CDS 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" /label="rapC CDS" gene 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /label="rapC gene" promotor_-35 411246..411251 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411264 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 411268..411286 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411408..411416 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411428..411446 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411440 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" /label="phrC CDS" gene 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /label="phrC gene" downshifts 411639 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(411707) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" /label="yczM CDS" gene complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /label="yczM gene" downshifts complement(411912) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" /label="yczN CDS" gene complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /label="yczN gene" promotor_-10 complement(412057..412076) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412068) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(412089..412098) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" /label="thrD CDS" gene complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /label="thrD gene" downshifts complement(412198) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(412242) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(413590..413609) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413606) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413624..413631) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413745..413749 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413765..413784 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413777 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 413808..413815 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413829..413848 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 413838..413938 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 413838 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" CDS 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" /label="pbtN CDS" gene 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /label="pbtN gene" CDS 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" /label="pbtO CDS" gene 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /label="pbtO gene" CDS 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" /label="pbtP CDS" gene 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /label="pbtP gene" CDS 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" /label="pbtQ CDS" gene 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /label="pbtQ gene" downshifts 417539 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" /label="ycnB CDS" gene complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /label="ycnB gene" downshifts complement(417624) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" /label="ycnC CDS" gene complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /label="ycnC gene" S_feature complement(419920..419986) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(419985..420004) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(419994) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(420019..420025) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" /label="nfrAB CDS" gene complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /label="nfrAB gene" downshifts complement(420096) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" /label="ycnE CDS" gene complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /label="ycnE gene" promotor_-35 421102..421109 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421123..421142 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421142 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(421180..421199) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421196) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421213..421220) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421241..421248 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421253 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 421259..421278 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" /label="yczG CDS" gene 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /label="yczG gene" downshifts 421582 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(421916..421927) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421922) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421941..421947) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423074..423093) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423075..423082 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423081) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 423096..423115 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423100 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(423104..423111) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 424326..424332 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424346..424364 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424354 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 424450..424457 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424472..424491 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424481 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 425913 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 425963..425969 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 425983..425994 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 425984 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 427016..427035 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427016 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 427104 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 427698 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(427752) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(430622..430641) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430637) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(430655..430662) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 430722..430741 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 430734 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 431089 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 431182..431189 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431203..431222 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431208 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 431218..431290 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 434289 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 434335..434338 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434354..434373 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434356 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 434631..434639 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434653..434672 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434663 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 435455 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 435528..435535 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435548..435567 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435561 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 436160..436884 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(436845..436864) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 436861..436867 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(436868) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436880..436899 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 436886 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 437282 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(437358) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(437512..437530) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437534) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(437545..437551) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437564..437571 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437585..437604 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437588 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 438361 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(438437) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 438467..438473 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438487..438506 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438493..438589 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438493 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 442652 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 442746..442846 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 442806 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 443932..443941 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443955..443974 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443965 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 444625 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(444637..445062) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(444682) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 444715..444721 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444735..444754 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444736 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 445058..445468 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(445371..445390) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445387) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 445444..445448 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445465..445484 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445470 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 447508..447608 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 448491 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 448584..448591 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448605..448624 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 448609..448696 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 448609 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 450768 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 450810..450816 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450830..450848 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450842 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 450853..450934 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 450896..450903 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450917..450936 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450936 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 452488 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(452557) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(453136..453154) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453150) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(453169..453175) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453211..453217 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453229 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 453232..453250 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 454636 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 454684..454691 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454705..454724 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454707 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 455307..455313 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455328..455346 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455341 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 455797..455805 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455816..455835 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 455835..456201 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 455835 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(455861..455961) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(455901) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 456158 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 456238..456247 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456260..456275 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456265 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 457088 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(457155) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(457469..457488) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457469..457487 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457475 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(457485) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 457563..457570 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457584..457603 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457588 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 458057..458060 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458069 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 458077..458096 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 460291 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 460357..460363 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460378..460396 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460379..460510 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460379 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 467507 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 467620..467627 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467642..467661 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 467649 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 467800 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 467845..467998 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 469814 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 470343..470349 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470364..470382 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470365 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(471233..472092) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472094..472205) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472105 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(472137) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(472165..472265) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472174..472179 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472196..472214 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472205) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 472206..472421 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472206 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(472272..472343) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472315) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(472626..472645) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472644) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(472657..472664) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(472733) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(474053..474072) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474065) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(474067..474144) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474085..474092) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474128..474147) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474144) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(474161..474170) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(474229) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(474295) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(475027..475045) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475044) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(475059..475065) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475077 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 475085..475104 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 475935 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476012..476018 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476032..476050 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476040 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(476077) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 476461 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(476495) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(476498..476501) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476523..476530 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476542..476561 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476549 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(476973..477266) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477211 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 477255 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(477311) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(478150..478168) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478171) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478182..478188) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 478525..478532 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478547..479334 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478547..478566 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478548 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(479278..479297) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479283) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(479311..479318) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 481613..481687 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 481654..481661 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481676..481693 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481689 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 482991 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(483045) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 483082..483099 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483084 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 484199..484442 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484399 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 486220..486239 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486225 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 486566 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 486611..486680 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 486646..486653 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486667..486686 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486681 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 487846 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(487907) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(488069..488237) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488229..488248) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488239) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488263..488270) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488378..488383 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488399..488417 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488403 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 488669..488678 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488691..488706 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488694 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(489250..489319) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489293) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 489306..489655 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 489636..489640 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489649..489663 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 489657..489814 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 489657 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(489661..489680) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489676) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489694..489701) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 490867 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 492355..492361 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492375..492386 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492385 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 492428..492447 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492429..492603 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492429 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 492571..492578 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492593..492612 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 492605..492672 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 492605 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 494201 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 494321..494380 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494321..494330 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494323 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 494342..494357 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 496301 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 496346..496673 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496355) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 496643..496648 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496661..496680 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496675..497276 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 496675 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(497206..497225) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497217) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 497645..497650 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 497666..497807 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 497666..497684 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 497666 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 498809 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 498869..498876 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498890..498909 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 498897 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 500037..500042 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500057..500075 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500063 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 500138..500141 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500157..500176 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500158 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(500650..501126) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(500693) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 500840 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 500894..500901 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500915..500934 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500923 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(501109..501127) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501126) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501128..501727) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501141..501148) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(501716..501734) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501727) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501729..502317) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(501748..501754) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(502315..502334) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502332) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(502348..502357) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 503587..503593 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 503608..503626 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 503614 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 505802 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 505860..505866 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505881..505900 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(505889,505891) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 505893 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 506320..506328 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506340..506359 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 506355 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(506588..509643) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 507191 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 507247..507248 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507264..507283 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507264 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 509457..509476 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509479..509695 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509479 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(509632..509651) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(509649) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509666..509674) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 510154..510160 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510175..510194 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510183..510270 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510183 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(510215) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 510887 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 510988..510989 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<510989..511295) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 511008 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(511040) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(511991..512010) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(512004) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(512025..512032) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 512104..512108 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 512125..512144 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 512129 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 512130..512574 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 512986..513055 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 513012 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 514687..514691 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 514708..514727 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 514717 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 517058..517617 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 518847..518851 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 518866..518885 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 518874 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(518921,518923) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 519114 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 520171..520178 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520192..520211 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 520203..520320 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 520203 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(520238) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(520419..521207) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 520424 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 520525 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 521678..522223 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(521721) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(521728..521747) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(521763..521770) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 522190 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(523580) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(523584..523603) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(525636..525641) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(525643..525644) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(525648) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 525717..525723 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 525731 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 525737..525756 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 527134 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 528569..528575 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528590..528609 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 528597 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 528608..528718 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 529194 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 529245..529252 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 529267..529286 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 529268 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 530038 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(530114) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 530127..530134 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530148 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530149..530168 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(531055..531074) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531062) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(531086..531091) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 532334..532340 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 532355..532374 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(532356..532375) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 532370 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(532380) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532390..532397) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 533965..533972 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 533983..534002 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 533997 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 534457..535711 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(534514) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(535082..535162) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(535509..535528) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(535526) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 535700..535719 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 535713 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 536506 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 536704 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(536781) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(537156..537220) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 537208..537215 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(537209..537228) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537222) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 537229..537248 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 537232 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(537243..537250) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 539326..539330 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 539344 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 539345..539364 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 540268 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 540401..540404 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 540411..540597 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 540411 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 540419..540438 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 542697..542705 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 542716..542734 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 542733 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 542798 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 543546 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(546859..546878) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 546867..546874 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546878) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 546889..546908 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546891 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546893..546899) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 547638 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(547690) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(548151..548170) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548175) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548184..548191) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 548484..548486 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548502..548521 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548518 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 550652 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(550685..550704) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550706) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(550718..550725) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 550766..550771 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 550784 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 550786..550804 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(551850..551868) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(551850) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(552952..553359) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 552969..552973 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 552983 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 552986..553005 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(552997) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(554263..554358) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(554338..554357) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(554358) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(554371..554378) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(556084..556103) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(556097) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(556119..556126) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(556186) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(557060..557152) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(557133..557152) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(557150) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(557168..557175) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 557341..557348 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 557363..557382 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 557369 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 557879..557885 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 557890 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 557899..557917 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 559097..559100 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559115..559134 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559122..559210 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 559122 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 559591 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 559714..559733 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 559716..559785 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 559716 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 560112 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(560188) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 560212..560218 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560233..560244 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 560244 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(560401..560562) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(560566..560931) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(560606) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 561146 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(561183..561202) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561200) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(561202..561285) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(561216..561225) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(561934..561945) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561948) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561960..561966) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(561964..562797) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 561979..561984 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561999..562010 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562004 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(563792..563811) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(563796) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563825..563834) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563989..563996 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 564012..564031 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 564020 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 564998..565159 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 565634..566326 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(565776) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(567471..567668) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 567485..567487 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567504..567522 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567508 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(567514) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 567634 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567660..567679) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567672) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567692..567699) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(567755) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(569182..569201) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(569197) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(569271,569273) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 569272..569305 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(569318) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569848..569867) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569867) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569883..569886) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569904..569911 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569926..569945 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569944 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS 569991..570449 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388445.1" /db_xref="EnsemblGenomes-Gn:BSU05640" /db_xref="EnsemblGenomes-Tr:CAB12371" /db_xref="GOA:P96705" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12174" /db_xref="UniProtKB/Swiss-Prot:P96705" /translation="MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLL KILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITP SGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE*" /label="ydgG CDS" gene 569991..570449 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /label="ydgG gene" CDS 570446..573103 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388446.1" /db_xref="EnsemblGenomes-Gn:BSU05650" /db_xref="EnsemblGenomes-Tr:CAB12372" /db_xref="GOA:P96706" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12175" /db_xref="UniProtKB/Swiss-Prot:P96706" /translation="MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPAD AVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPL SAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQ DFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVY NVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTL FISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPS KKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYK SIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTI TQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNG GSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQAN QQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTG IFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEV DGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYM IASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEE VHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGL VILPLFIPAIIATFGEGNWWPFGRKKGKE*" /label="ydgH CDS" gene 570446..573103 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /label="ydgH gene" downshifts 573224 /Source="Nicolas_upshifts" /id="D272" /incds=0 /nref=3 /ntot=27 /MaxReadThrough="0.245049999999999" /MaxDrop="4.45167" /score="13.780898" /energy="-13.9" /TU="NA" /idTUdmin="U439" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(573249..573878) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26415543; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase of unidentified specificity (reduces 5-(aziridin-1-yl)-2,4-dinitrobenzamide prodrug)" /protein_id="NP_388447.1" /db_xref="EnsemblGenomes-Gn:BSU05660" /db_xref="EnsemblGenomes-Tr:CAB12385" /db_xref="GOA:P96707" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12176" /db_xref="UniProtKB/Swiss-Prot:P96707" /translation="MIKTNDFMEIMKGRRSIRNYDPAVKISKEEMTEILEEATTAPSS VNAQPWRFLVIDSPEGKEKLAPLASFNQTQVTTSSAVIAVFADMNNADYLEEIYSKAV ELGYMPQEVKDRQIAALTAHFEKLPAQVNRETILIDGGLVSMQLMLTARAHGYDTNPI GGYDKENIAETFGLDKERYVPVMLLSIGKAADEGYASYRLPIDTIAEWK*" /label="ydgI CDS" gene complement(573249..573878) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /label="ydgI gene" downshifts complement(573253) /Source="Nicolas_upshifts" /id="D273" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="2.66406" /MaxDrop="6.06581" /score="21.7451043" /energy="-16.6" /TU="NA" /idTUdmin="U440" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(573894..574388) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388448.1" /db_xref="EnsemblGenomes-Gn:BSU05670" /db_xref="EnsemblGenomes-Tr:CAB12386" /db_xref="GOA:P96708" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12177" /db_xref="UniProtKB/Swiss-Prot:P96708" /translation="MTCQSLIYQLIVLTGKKGWVLASFCSEEAEILYQLQGVNKVIGV KFEACTGISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRR KPEDNRITLVRLTDQGRERIESSKKEKERFMKEMLANVSAEERRLLIDVLARMRNNIN NIEA*" /label="ydgJ CDS" gene complement(573894..574388) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /label="ydgJ gene" promotor_-10 complement(574380..574399) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(574395) /Source="Nicolas_upshifts" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(574415..574420) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 574586..574588 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 574604..574623 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 574610..574698 /Source="Nicolas_S_feature" /locus_tag="new_613552_613640" /HighExp="H2O2, G180, G135, Diami, Paraq, Oxctl, G150, LBGexp, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S199" upshifts 574610 /Source="Nicolas_upshifts" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="upshifts" CDS 574699..575907 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388449.1" /db_xref="EnsemblGenomes-Gn:BSU05680" /db_xref="EnsemblGenomes-Tr:CAB12387" /db_xref="GOA:P96709" /db_xref="InterPro:IPR004812" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12178" /db_xref="UniProtKB/Swiss-Prot:P96709" /translation="MLHNPTGKERLALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSA SASLVQLSLTACLVGLTIGQLIVGPVSDAQGRRKPLLICIFLFALSSLFCALSPNITT LVAARFLQGFTASAGLVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL LLPFATWHTIFHVLMIIGFLLVLLIALRLKETLPLEKRIPSSIGTSVKTMGSLLKDRS FMGYALTVGFIHGGSFAYVSGTPFVYQDIYGVSPQVFSILFGINGLAIISGSFIIGRF GGIIHEKSLLRIAVITAMIATAVLLTMTMIHGPLATLVISIFIYMITIGMVLTSTFTL AMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINETTAVPMGAIMFVTAVIGSLAFFG LTKERVGQNS*" /label="ydgK CDS" gene 574699..575907 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /label="ydgK gene" downshifts 575886 /Source="Nicolas_upshifts" /id="D274" /incds=0 /nref=23 /ntot=112 /MaxReadThrough="0.507390000000001" /MaxDrop="3.27202" /score="25.806679" /energy="-7.5" /TU="NA" /idTUdmin="U441" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(575943..576680) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388450.2" /db_xref="EnsemblGenomes-Gn:BSU05690" /db_xref="EnsemblGenomes-Tr:CAB12388" /db_xref="GOA:O05493" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG12179" /db_xref="UniProtKB/Swiss-Prot:O05493" /translation="MLIILVMFLLGIILGFIGAGGAGFVIALLTLLFHIPIHTALGTS LAGMAFTSLSGAYSHYREGNIQMKIGLIVGGFAAVGSFFGAKLTSFIPADLLHYLTAG MLFLSAILILIRLFILKEKAQVNQSTLSTYTRAVILGIAAGVLSGTFGIGSAPFIQIG LMIMLNLSIRHSVGTTMLVIIPLAVGGGIGYITEGFVDYVLLVKVLVGTMCGAYVGAK FTNLMPKVVLKSAIFLTPAIAGLLLLF*" /label="ydhB CDS" gene complement(575943..576680) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /label="ydhB gene" S_feature complement(576681..576819) /Source="Nicolas_S_feature" /locus_tag="new_615623_615761_c" /HighExp="T0.30H, T1.30H, T1.0H, T-0.40H, T2.0H, T0.0H, LBGstat, T2.30H, T-1.10H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.108111" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S200" promotor_-10 complement(576807..576826) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576819) /Source="Nicolas_upshifts" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(576840..576847) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 576851..576858 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 576872..576891 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576876 /Source="Nicolas_upshifts" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="upshifts" CDS 576929..577603 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388451.1" /db_xref="EnsemblGenomes-Gn:BSU05700" /db_xref="EnsemblGenomes-Tr:CAB12389" /db_xref="GOA:O05494" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12180" /db_xref="UniProtKB/Swiss-Prot:O05494" /translation="MDDFKLDKPTPYYLQFYNQLKKMIFNGTFKPGERINETQLAKSF GVSRSPIREAMRLLEKDGLLKADDRNGFSITSLTAKDVDEIYKIRIPLEQLAVELVID EADEEELTILEKQLEETEKAIHNGTEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVN DLIHFCRILNYTGDHRAETILREHRRIFEEVKKKNKEAAKQHVLAHFNHDCEHLKHVL EEGKEN*" /label="ydhC CDS" gene 576929..577603 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /label="ydhC gene" promotor_-35 577662..577667 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 577683..577701 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 577689 /Source="Nicolas_upshifts" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="upshifts" CDS 577730..578992 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11011148, 12177332; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore cortex lytic enzyme" /protein_id="NP_388452.2" /db_xref="EnsemblGenomes-Gn:BSU05710" /db_xref="EnsemblGenomes-Tr:CAB12390" /db_xref="GOA:O05495" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:3CZ8" /db_xref="SubtiList:BG12181" /db_xref="UniProtKB/Swiss-Prot:O05495" /translation="MFIHIVGPGDSLFSIGRRYGASVDQIRGVNGLDETNIVPGQALL IPLYVYTVQPRDTLTAIAAKAFVPLERLRAANPGISPNALQAGAKITIPSISNYIAGT LSFYVLRNPDLDRELINDYAPYSSSISIFEYHIAPNGDIANQLNDAAAIETTWQRRVT PLATITNLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFEQVSAAD RDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMAYD WHHAGSEPGPVAPITEIRRTIEFTIAQVPSRKIIIGVPLYGYDWIIPYQPGTVASAIS NQNAIERAMRYQAPIQYSAEYQSPFFRYSDQQGRTHEVWFEDVRSMSRKMQIVREYRL QAIGAWQLTLGFTPGPWLLRKFFTIRKV*" /label="spoL CDS" gene 577730..578992 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /label="spoL gene" downshifts 578966 /Source="Nicolas_upshifts" /id="D275" /incds=0 /nref=33 /ntot=81 /MaxReadThrough="2.3134" /MaxDrop="5.20337" /score="15.7593331" /energy="-7.1" /TU="NA" /idTUdmin="U444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 579064..579071 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 579085..579104 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 579089 /Source="Nicolas_upshifts" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="upshifts" CDS 579153..580340 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388453.2" /db_xref="EnsemblGenomes-Gn:BSU05720" /db_xref="EnsemblGenomes-Tr:CAB12391" /db_xref="GOA:O05496" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG12182" /db_xref="UniProtKB/Swiss-Prot:O05496" /translation="MKTVLILNFPAEGHVNPTLGITKAFSDKGYDVHYISTEKYKKRL EAAGATVHLHRDLLRTTPIHVGSPNGILDFVKIHIKTSLDILQIVKDLSKSIQFDFVY YDKFGAGELVRDYLDIPGVSSSASFLFGEEHLKILPLHPESGAPLELDQECEDLLAKM KETYGVAPKNLVQFMNNKGELNVVYTSRYFQPESDRFGDECLFIGPSFPKRAEKTDFP IEQLKDEKVIYISMGTVLDHTEDFFNLCIDAFSGFNGKVVIAAGEKADLTKLKQAPEN FIIAPYVPQLEVLEQSDVFITHGGMNSVNEGIHFSVPLVVMPHDKDQPMVAQRLSELH AGYVISKDEVNAQILKQAVDEVLRNDQYTAGIKKINQSFKECMDMEEVMERIDELIRQ KNK*" /label="ydhE CDS" gene 579153..580340 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /label="ydhE gene" downshifts 580352 /Source="Nicolas_upshifts" /id="D276" /incds=0 /nref=17 /ntot=224 /MaxReadThrough="1.77672" /MaxDrop="5.25325" /score="-6.36206618" /energy="-12.6" /TU="NA" /idTUdmin="U445" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(580379..581089) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913081, 11557812; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative phosphate-starvation lipoprotein" /protein_id="NP_388454.1" /db_xref="EnsemblGenomes-Gn:BSU05730" /db_xref="EnsemblGenomes-Tr:CAB12392" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12183" /db_xref="UniProtKB/Swiss-Prot:O05497" /translation="MRRILSILVFAIMLAGCSSNASTEKQHAGGEKTVKAEPQSTSSQ KDSTDDYQPNSQVTDDRTLHKVGQTFSDDKGKAVLKDIKQVNKTYKIGDVELTVKEMK LIHLRPDYSMIDYFHELTHDEEFDFVKVFVDIKNTSTKKVNVAPIALMKTNTGETFDW NKDIYLEELNGELEGGAEKSGNLGFIVNASSGHAHDKAADAEKKTKEIKWIEITTSDV FDHNHKKISDAQKIKIKF*" /label="ydhF CDS" gene complement(580379..581089) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /label="ydhF gene" downshifts complement(580405) /Source="Nicolas_upshifts" /id="D277" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="4.05808" /MaxDrop="4.7318" /score="13.7192471" /energy="-12.6" /TU="NA" /idTUdmin="U446" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(581155..582543) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9335276, 10913081, 16030210, 16491025, 26382712, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9335276, 10913081, 16030210, 16491025, 26382712, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase III (promiscuous, heptaprenylglyceryl phosphate is a substrate)" /protein_id="NP_388455.2" /db_xref="EnsemblGenomes-Gn:BSU05740" /db_xref="EnsemblGenomes-Tr:CAB12393" /db_xref="GOA:P19405" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10697" /db_xref="UniProtKB/Swiss-Prot:P19405" /translation="MKKFPKKLLPIAVLSSIAFSSLASGSVPEASAQEKKKGNQDEIK NVIVLIGDGMGVSYTSAYRYLKDNKKTKVVEPTAFDQYLVGQQTTYPDDPEQNVTDSA AAATAMSAGIKTYNNAIAVDNDGSEAKTVLEAAKEKGKATGLVATSEITHATPASFGS HDHSRKNMNSIADDYFDEMVNGKHKIDVLLGGGKSNFDRKDRNLIKEFKKAGYSYVDD RKDMLKNKDSQVLGLFADGGLPKKIDRTKDIPSLKDMTNTAIKKLNKDKDGFFLMVEG SQIDWAGHDNDIVGAMSEMEDFEQAYKAAIDFAKKDKHTLVVATADHSTGGYSIGADG IYNWFSEPIKAAKRTPDFMAEKIADGADVEKTLKTYIDQKKLALTKAEIQSVEEAAKS KEVLDIDNAIENIFNKRSHTGWTTGGHTGEDVPVYAYGPSSETFAGQIDNTEIAKNVF KALQYNIKINDK*" /label="phoB CDS" gene complement(581155..582543) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /label="phoB gene" promotor_-10 complement(582600..582617) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582601) /Source="Nicolas_upshifts" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(582603..582671) /Source="Nicolas_S_feature" /locus_tag="new_621545_621613_c" /HighExp="S6, S4, S5, S3, S7, LoTm, S8, T5.0H, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S201" promotor_-35 complement(582624..582631) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(582661..582679) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582679) /Source="Nicolas_upshifts" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(582695..582700) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 582748..582755 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582769..582788 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 582771..582904 /Source="Nicolas_S_feature" /locus_tag="new_621713_621846" /HighExp="Diami, dia15, H2O2, Paraq, Oxctl, HPh, G180, G135, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S202" upshifts 582771 /Source="Nicolas_upshifts" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="upshifts" CDS 582905..583276 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:20087498, 21744456, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20087498, 21744456, 25826316; Product type f: factor" /codon_start=1 /transl_table=11 /product="frataxin; iron/sulfur chaperone" /protein_id="NP_388456.1" /db_xref="EnsemblGenomes-Gn:BSU05750" /db_xref="EnsemblGenomes-Tr:CAB12394" /db_xref="GOA:Q797E6" /db_xref="InterPro:IPR014922" /db_xref="PDB:2OC6" /db_xref="SubtiList:BG12184" /db_xref="UniProtKB/Swiss-Prot:Q797E6" /translation="MDVFSEYLAGIADPFHRERTEEVLTWIKNKYPNLHTEIKWNQPM FTDHGTFIIGFSVSKKHLAVAPEKVTIAHVEDDIVKAGYDYTEQLIRIPWNGPVDYTL LEKMIEFNILDKADCSTFWRK*" /label="fra CDS" gene 582905..583276 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /label="fra gene" downshifts 583255 /Source="Nicolas_upshifts" /id="D278" /incds=0 /nref=9 /ntot=150 /MaxReadThrough="2.88587" /MaxDrop="3.59127" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U448" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(583350) /Source="Nicolas_upshifts" /id="D279" /incds=0 /nref=9 /ntot=187 /MaxReadThrough="1.63268" /MaxDrop="2.98181" /score="0.51805655" /energy="-13" /TU="NA" /idTUdmin="U450" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(583351..583848) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388457.1" /db_xref="EnsemblGenomes-Gn:BSU05760" /db_xref="EnsemblGenomes-Tr:CAB12395" /db_xref="GOA:O05500" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG12185" /db_xref="UniProtKB/Swiss-Prot:O05500" /translation="MSSHYKYPLIFTAFLLIAFCLIFFSYHLIHHVRLEYPNWQGESK DQNWEAVFTKNEDAPNEYSGKLYWIGDTIEIDNTYLESLIVKKDDEVLLSSDTEIPMH DYAGGTFSDGSAKEKSVSFLERLDEHELEGHDITIEVKWKQGNHYSASQLTLNEKTLF DEKQQ*" /label="ydhH CDS" gene complement(583351..583848) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /label="ydhH gene" CDS complement(583866..584348) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388458.1" /db_xref="EnsemblGenomes-Gn:BSU05770" /db_xref="EnsemblGenomes-Tr:CAB12396" /db_xref="GOA:O05501" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12186" /db_xref="UniProtKB/Swiss-Prot:O05501" /translation="MMIIIPNNEIAKHMLTDFFAKHWGTPEMAISSGIFRCDELDGFA AVNESGEIIGCITYTIDGKDCEIISLDSMIENKGIGTALLQQVEEKAKHAHCQRIKLI TTNDNVNAIAFYQKRGYQFAAVFPNAVEKARRLKPEIPEVAENGILIRDEILFSKVID *" /label="ydhI CDS" gene complement(583866..584348) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /label="ydhI gene" promotor_-35 584021..584028 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584042..584061 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584046 /Source="Nicolas_upshifts" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(584377..584396) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(584387) /Source="Nicolas_upshifts" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(584411..584414) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 584431..585408 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_388459.1" /db_xref="EnsemblGenomes-Gn:BSU05780" /db_xref="EnsemblGenomes-Tr:CAB12397" /db_xref="GOA:O05502" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG12187" /db_xref="UniProtKB/Swiss-Prot:O05502" /translation="MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRK WNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENI FQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGH INLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARA LKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQ KKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ*" /label="ydhJ CDS" gene 584431..585408 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /label="ydhJ gene" downshifts 585388 /Source="Nicolas_upshifts" /id="D280" /incds=0 /nref=2 /ntot=92 /MaxReadThrough="2.31799" /MaxDrop="3.19063" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U451" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 585435..585441 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585456..585474 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585464 /Source="Nicolas_upshifts" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 585500..585507 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 585520 /Source="Nicolas_upshifts" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 585521..585540 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 585550..586167 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388460.1" /db_xref="EnsemblGenomes-Gn:BSU05790" /db_xref="EnsemblGenomes-Tr:CAB12398" /db_xref="InterPro:IPR011438" /db_xref="PDB:2KY9" /db_xref="PDB:4FIB" /db_xref="PDB:4MDW" /db_xref="SubtiList:BG12188" /db_xref="UniProtKB/Swiss-Prot:O05503" /translation="MSAGKSYRKKMKQRRMNMKISKYALGILMLSLVFVLSACGNNNS TKESTHDNHSDSSTHEEMDHSGSADVPEGLQESKNPKYKVGSQVIINTSHMKGMKGAE ATVTGAYDTTAYVVSYTPTNGGQRVDHHKWVIQEEIKDAGDKTLQPGDQVILEASHMK GMKGATAEIDSAEKTTVYMVDYTSTTSGEKVKNHKWVTEDELSAK*" /label="ydhK CDS" gene 585550..586167 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /label="ydhK gene" downshifts 586154 /Source="Nicolas_upshifts" /id="D281" /incds=0 /nref=62 /ntot=212 /MaxReadThrough="1.07295" /MaxDrop="7.27889" /score="30.3859931" /energy="-11.4" /TU="U452" /idTUdmin="U451" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(586183..587349) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12923093, 15849754, 16850406, 17935948, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15849754, 16850406, 17935948, 25573585; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine efflux transporter" /protein_id="NP_388461.2" /db_xref="EnsemblGenomes-Gn:BSU05800" /db_xref="EnsemblGenomes-Tr:CAB12399" /db_xref="GOA:Q797E3" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12189" /db_xref="UniProtKB/Swiss-Prot:Q797E3" /translation="MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLI SVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAA MSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILF LGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTL YAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFA IIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQ VGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL*" /label="pbuE CDS" gene complement(586183..587349) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /label="pbuE gene" downshifts complement(586212) /Source="Nicolas_upshifts" /id="D282" /incds=0 /nref=40 /ntot=58 /MaxReadThrough="2.22188" /MaxDrop="4.89202" /score="36.362851" /energy="-12.4" /TU="NA" /idTUdmin="U453" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(587404..587504) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /product="adenine riboswitch" /experiment="publication(s) with functional evidences, PMID:14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585; Product type n: RNA" /label="aswA RNA" gene complement(587404..587504) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /label="aswA gene" downshifts complement(587445) /Source="Nicolas_upshifts" /id="D283" /incds=0 /nref=38 /ntot=127 /MaxReadThrough="5.85661" /MaxDrop="6.06248" /score="33.0784595" /energy="-19.4" /TU="U453" /idTUdmin="U453" /TUdmin="-1233" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(587514..587533) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(587528) /Source="Nicolas_upshifts" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(587549..587553) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 587612..587619 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587633..587652 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587640 /Source="Nicolas_upshifts" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="upshifts" CDS 587680..587991 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18177310; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIB" /protein_id="NP_388462.1" /db_xref="EnsemblGenomes-Gn:BSU05810" /db_xref="EnsemblGenomes-Tr:CAB12400" /db_xref="GOA:O05505" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG12190" /db_xref="UniProtKB/Swiss-Prot:O05505" /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKE DMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVN Q*" /label="gmuB CDS" gene 587680..587991 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /label="gmuB gene" CDS 587991..588323 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIA" /protein_id="NP_388463.2" /db_xref="EnsemblGenomes-Gn:BSU05820" /db_xref="EnsemblGenomes-Tr:CAB12401" /db_xref="GOA:O05506" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG12191" /db_xref="UniProtKB/Swiss-Prot:O05506" /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEA DALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEML DLFKTKNI*" /label="gmuA CDS" gene 587991..588323 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /label="gmuA gene" CDS 588342..589670 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18177310; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIC" /protein_id="NP_388464.1" /db_xref="EnsemblGenomes-Gn:BSU05830" /db_xref="EnsemblGenomes-Tr:CAB12402" /db_xref="GOA:O05507" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG12192" /db_xref="UniProtKB/Swiss-Prot:O05507" /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVV LTNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGG AIALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKN LTIKMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLV GLGSGIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHI ISKPFMEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGL PIVMNPIIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIM GGVMQLINLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM*" /label="gmuC CDS" gene 588342..589670 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /label="gmuC gene" CDS 589688..591085 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18177310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannoside-phospho-beta-d-glucosidase" /protein_id="NP_388465.1" /db_xref="EnsemblGenomes-Gn:BSU05840" /db_xref="EnsemblGenomes-Tr:CAB12403" /db_xref="GOA:O05508" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="SubtiList:BG12193" /db_xref="UniProtKB/Swiss-Prot:O05508" /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEK EPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAA DFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGG RVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQD GKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGF MPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRK MNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRI EFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVK KSGKWFKEVAEHSGF*" /label="gmuD CDS" gene 589688..591085 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /label="gmuD gene" S_feature 591086..591172 /Source="Nicolas_S_feature" /locus_tag="new_630028_630114" /HighExp="G150, T0.30H, T1.0H, M40t90, T1.30H, Mt0, M0t90, Lbexp, dia0, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S203" promotor_-35 591150..591157 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 591171..591190 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 591174 /Source="Nicolas_upshifts" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="upshifts" CDS 591228..591941 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18177310; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388466.1" /db_xref="EnsemblGenomes-Gn:BSU05850" /db_xref="EnsemblGenomes-Tr:CAB12404" /db_xref="GOA:O05509" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12194" /db_xref="UniProtKB/Swiss-Prot:O05509" /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMK RALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQF EVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDS IYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEY SFSRHRHDKFVVTSVNIRR*" /label="gmuR CDS" gene 591228..591941 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /label="gmuR gene" CDS 591970..592869 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /EC_number="2.7.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15018644, 18177310, 21185308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15018644, 18177310, 21185308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ROK fructokinase; glucomannan utilization protein E" /protein_id="NP_388467.1" /db_xref="EnsemblGenomes-Gn:BSU05860" /db_xref="EnsemblGenomes-Tr:CAB12405" /db_xref="GOA:O05510" /db_xref="InterPro:IPR000600" /db_xref="PDB:1XC3" /db_xref="PDB:3LM9" /db_xref="PDB:3OHR" /db_xref="SubtiList:BG12195" /db_xref="UniProtKB/Swiss-Prot:O05510" /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQY FSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFST DVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHP DDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYIL ILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAG IIGTLVLAHQALQAEAASGEVRS*" /label="gmuE CDS" gene 591970..592869 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /label="gmuE gene" CDS 592866..593813 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10704478, 18177310, 3017192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphohexomutase; cupin family" /protein_id="NP_388468.1" /db_xref="EnsemblGenomes-Gn:BSU05870" /db_xref="EnsemblGenomes-Tr:CAB12406" /db_xref="GOA:O05511" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG12196" /db_xref="UniProtKB/Swiss-Prot:O05511" /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHA HGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDY AKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKP GDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVIT IPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSG RIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP*" /label="gmuF CDS" gene 592866..593813 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /label="gmuF gene" CDS 593832..594920 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /EC_number="3.2.1.78" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2694961, 7727534, 18177310, 28101462, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2694961, 7727534, 18177310, 28101462, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported mannan endo-1,4-beta-mannosidase" /protein_id="NP_388469.2" /db_xref="EnsemblGenomes-Gn:BSU05880" /db_xref="EnsemblGenomes-Tr:CAB12407" /db_xref="GOA:O05512" /db_xref="InterPro:IPR000805" /db_xref="InterPro:IPR016714" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR022790" /db_xref="PDB:2WHK" /db_xref="PDB:3CBW" /db_xref="SubtiList:BG12197" /db_xref="UniProtKB/Swiss-Prot:O05512" /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVM NWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETA NIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTV EGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYK QLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSIN GYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNK GASALYHDSWTLNKGEIWNGDSLTPIVE*" /label="gmuG CDS" gene 593832..594920 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /label="gmuG gene" downshifts 594914 /Source="Nicolas_upshifts" /id="D284" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="1.56881" /MaxDrop="2.87204" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U454" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(594981..595709) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTFRETLAFLIVRDNAHQNAFAKALETLGVEWAKL LPVPNYDINKYPECRKYVELGYHNTHFNFRLDETRISEIYQGKSPSRNGGELQVIDPP AGFPVPVLPEIPNEHSPGLGDMNA*" /label="ydhUc CDS" gene complement(594981..595709) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /pseudo /label="ydhUc gene" downshifts complement(595031) /Source="Nicolas_upshifts" /id="D285" /incds=0 /nref=13 /ntot=37 /MaxReadThrough="1.1517" /MaxDrop="5.0503" /score="0.317473754" /energy="-17.6" /TU="NA" /idTUdmin="U456" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(595640..595834) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(595640..595834) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(595867..595878) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(595875) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(595892..595898) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 595953..595960 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 595974..595993 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 595976..596076 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 595978 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(596024) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 596036 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 596044..596051 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 596065..596084 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 596080..596167 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 596080 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 596168..596244 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 596168..596244 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 596258..596331 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 596258..596331 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 596491..598045 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 596491..598045 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 598213..601140 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 598213..601140 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 601196..601312 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 601196..601312 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 601326..601402 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 601326..601402 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 601463..601539 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 601463..601539 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 601536 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 601640..601644 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 601660..601679 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 601664 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 601720..602697 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 601720..602697 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 602712..603188 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 602712..603188 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 603169..603858 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 603169..603858 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 603868..604323 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 603868..604323 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 604316..605356 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 604316..605356 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 605320 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(605586..607514) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(605586..607514) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(605603) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 607266..607285 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 607276 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 607278..607467 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 607432..607439 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 607453..607472 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 607469..607639 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 607469 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(607534..607553) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607546) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607567..607574) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 607640..608152 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 607640..608152 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 608149..608796 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 608149..608796 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 608626..608726 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 608686 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 608818..608991 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 608818..608991 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 608998..609762 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 608998..609762 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 609742 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(609800..609991) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(609800..609991) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(609817) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(609988..610722) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(609988..610722) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 610380..610385 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 610400..610418 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 610402 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 610721..610722 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 610732..610746 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 610754 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(610759..610778) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 610776..610884 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(610779) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(610792..610797) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 610858..610864 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 610878..610897 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 610886..610960 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 610886 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 610961..611245 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 610961..611245 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 611292..612926 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 611292..612926 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 612927..613019 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 612976 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(613014..613142) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(613014..613142) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 613021..>614247 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(613145..613303) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(613145..613303) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(613348..613476) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(613348..613476) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(613569..613778) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(613569..613778) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(613771..614076) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(613771..614076) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(614247,614254) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 614248..614253 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(614352..616841) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(614352..616841) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(614374) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(616855..616874) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616881) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(616888..616895) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 616944..616945 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 616960..617042 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 616960 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 616961..616980 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 617043..618104 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 617043..618104 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 618178..619569 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 618178..619569 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 619596..619603 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 619617..619636 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 619622 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 619664..620626 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 619664..620626 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 620611 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 620751..620760 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 620767 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620773..620788 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620822..621505 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 620822..621505 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 621506..621570 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 621571..622596 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 621571..622596 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 622596..623360 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 622596..623360 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 623391..624362 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 623391..624362 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 624352 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 624396 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(624409..625434) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(624409..625434) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(625466..625485) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(625484) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(625499..625505) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 625694..625701 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 625714 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 625716..626018 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 625716..625735 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 626019..627440 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 626019..627440 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 627432 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(627488) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(627488..628528) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(627488..628528) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 628068..628077 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 628091..628110 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 628092..628627 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 628092 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(628529..628823) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 628628..628647 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 628629..628926 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 628629 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(628818..628832) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(628823) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 628925..628944 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 628928 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 628967..629338 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 628967..629338 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 629324 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 629404..630450 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 629404..630450 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 630424 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(630484..630642) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(630484..630642) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(630500) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(630699..630831) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(630742) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(630832..631041) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(630832..631041) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(631074..631093) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(631085) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(631124..631939) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(631124..631939) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 631766..631775 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631788..631807 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 631788 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(631952..632941) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(631952..632941) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(632806..632824) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632814) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632840..632845) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(632963..632978) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632984) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632990..632999) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(633039..634580) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(633039..634580) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(633052) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(634611..634630) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(634625) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(634644..634653) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(634732..636141) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(634732..636141) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(634746) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(636179..636466) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(636179..636466) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(636182..636201) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(636196) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 636472..636479 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 636495..636514 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 636496 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 636539..637411 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 636539..637411 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 637376 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(637651) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 637705..637724 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 637715 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 637761..638723 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 637761..638723 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 638723..639919 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 638723..639919 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 639941..642154 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 639941..642154 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 642149..642156 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 642171..642190 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 642187..642316 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 642187 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 642317..643858 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 642317..643858 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 643844 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 643965..643969 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 643985..644004 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 643995 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 644002..644104 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 644002..644104 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 644130 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 644239..645561 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 644239..645561 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 645539 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 645582 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 645611..645620 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 645631..645771 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 645631 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 645633..645648 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 645772..646575 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 645772..646575 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 646560 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 646643..646650 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646664..646683 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646670..646733 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 646670 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 646734..646901 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 646734..646901 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 646908 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 646952..646958 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646973..646991 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646976..647062 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 646976 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 647041..647048 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 647062..647081 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 647064 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 647115..647669 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 647115..647669 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 647669..647866 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 647669..647866 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 647856 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 647912..647919 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 647934..647953 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 647936 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 647946..648048 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 647946..648048 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 648049..648188 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 648189..648677 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 648189..648677 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 648670..649812 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 648670..649812 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 649809..651104 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 649809..651104 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(650114..650133) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650135) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(650148..650155) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 651178..651903 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 651178..651903 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 651896..652150 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 651896..652150 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 652147..652830 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 652147..652830 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 652814..655042 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 652814..655042 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(653062) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 655018..656448 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 655018..656448 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 656449..656549 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 656550..657590 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 656550..657590 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 657587..658174 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 657587..658174 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 657597..657611 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 657606 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(657873..657891) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657880) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(657907..657912) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 658171..659709 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 658171..659709 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 659725..660993 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 659725..660993 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 660978 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(661033..661452) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(661033..661452) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(661522..661541) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(661531) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 661596..662870 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 661596..662870 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 662819 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(662885..663112) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(662885..663112) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(662896) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(663113..663533) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 663180..663185 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 663196 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 663199..663218 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 663241..664983 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 663241..664983 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(663518..663529) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(663533) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(663543..663549) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 663564 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 664957..664963 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 664975 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 664976..664995 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 665010..666005 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 665010..666005 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 666008..666322 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 666008..666322 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 666185 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 666327 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(666357..667934) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(666357..667934) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(666371) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(667948..667967) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667967) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(667982..667988) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 668131..668134 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 668148 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 668151..668170 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 668199..668885 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 668199..668885 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 668947..671166 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 668947..671166 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 671190..673196 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 671190..673196 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 673212..674402 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 673212..674402 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(673407..673411) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(673411) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 674439..674458 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 674447..674563 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 674447 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(674511) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 674564..675574 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 674564..675574 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(674581..674681) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(674621) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 675557 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 675601..676405 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(675612..676310) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(675612..676310) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(675633) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(676330..676348) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(676351) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(676364..676369) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(676417..677895) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(676417..677895) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(676431) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(677283) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(677286..677299) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(677896..678026) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(678017..678035) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(678026) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(678050..678056) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 678157..678160 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 678175..678308 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 678175 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 678177..678196 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 678309..678599 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 678309..678599 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 678615..680072 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 678615..680072 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 680086..681516 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 680086..681516 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 681497 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(681531..682400) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(681531..682400) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(681573) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 682190..682195 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 682211..682229 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 682223 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(682401..682475) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 682453..682460 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(682469..682488) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682475 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 682476..682495 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(682482) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(682503..682510) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 682532..685690 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 682532..685690 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 685677 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 685929..685932 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685947..685966 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685955 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 686013..686924 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 686013..686924 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 686925..687179 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 687180..688559 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 687180..688559 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 688560..689152 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(688572..689474) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(688572..689474) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 689109 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 689154..689454 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 689455..689790 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 689455..689790 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 689791..689864 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 689865..692504 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 689865..692504 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 692516..694315 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 692516..694315 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(692756..692771) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(692771) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(692783..692792) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 694316..694427 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 694428..695576 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 694428..695576 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 695577..696766 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(695838..696143) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(695838..696143) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(696210..696416) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(696210..696416) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(696656..697111) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(696656..697111) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(696669) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(697131..699140) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(697131..699140) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(697498..697517) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(697505) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(697530..697535) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(699167..699186) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(699177) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 699352..700374 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 699352..700374 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 700474..700481 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 700495..700514 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 700496 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 700536..701666 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 700536..701666 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 701656..701829 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 701656..701829 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 701784 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 701830..701934 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 701901..701908 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 701923..701942 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 701936 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 701989..702708 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 701989..702708 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(701991) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 702566..702573 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702587..702606 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702597 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 702690 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 702777..702786 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702800..702819 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702803 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(702807..702825) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(702827) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(702841..702846) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 702842..703279 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 702842..703279 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(702849) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 703279 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 703339..703346 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 703362..703381 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 703367 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 703394..703978 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 703394..703978 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 703959 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 704057..704500 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 704057..704500 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 704497..705357 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 704497..705357 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 705419..705424 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 705440..705458 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 705440 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(705462..705476) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(705467) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(705484..705488) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 705484..705732 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 705484..705732 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 705716..705979 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 705716..705979 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 705994..706563 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 705994..706563 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 706564..706642 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 706615..706620 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706635..706654 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706644 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 706688..707230 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 706688..707230 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 707197 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 707253..707555 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 707253..707555 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 707598..707606 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 707617..707635 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 707623 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 707670..708299 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 707670..708299 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 708296..710029 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 708296..710029 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 710029..711135 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 710029..711135 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 711089 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 711174..711177 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711192..711211 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711199 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 711239..712522 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 711239..712522 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 712519..713448 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 712519..713448 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 713452..714342 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 713452..714342 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 714358..715392 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 714358..715392 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 715415..717700 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 715415..717700 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 717714..718412 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 717714..718412 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 718405..719067 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 718405..719067 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 719064..719690 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 719064..719690 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 719811..721673 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 719811..721673 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 719851..719951 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 719911 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(720449) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(720450..720469) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(720482..720491) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 721719..723557 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 721719..723557 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 723715..724368 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 723715..724368 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 724376..726367 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 724376..726367 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 726411..728984 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 726411..728984 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(727733..727751) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(727746) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(727767..727772) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 729106..730614 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 729106..730614 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 730669..731625 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 730669..731625 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(730943) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(730969..731069) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(731009) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 731639..732526 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 731639..732526 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 732273..732278 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 732294..732312 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 732297 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 732535..733875 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 732535..733875 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(732969..734660) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 733876..733957 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 733958..734653 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 733958..734653 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 734651 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(734690..735016) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(734690..735016) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(734705) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 735003 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(735039..735058) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735057) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(735073..735080) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(735120..735482) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(735120..735482) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(735505..735524) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(735519) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(735537..735543) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(735553..736113) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(735585) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(736096..736115) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(736113) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(736129..736138) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 736201..736208 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 736217 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 736221..736240 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 736266..736847 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 736266..736847 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 736841..737137 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 736841..737137 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 737129 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 737208..737215 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737229..737248 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737237 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 737292..737459 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 737292..737459 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 737501..737508 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737524..737543 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737525 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 737569..738213 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 737569..738213 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 738149 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 738193 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 738213..739205 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 738213..739205 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 739139 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 739183 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(739229..739732) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(739229..739732) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(739757..739776) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(739765) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(739790..739797) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 739895..741004 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 739895..741004 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 740987 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(741039..742109) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(741039..742109) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(741063) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(742140..742159) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742166) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(742174..742181) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 742189..742195 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 742210..742228 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 742219 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 742259..745444 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 742259..745444 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 745431 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 745494..745499 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745515..745533 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 745536 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 745564..745567 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745584..745603 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 745585..745890 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 745585 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 745891..747810 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 745891..747810 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 747809 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 747898..747907 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 747917..748045 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 747917 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 747921..747940 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(747971) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 748046..748810 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 748046..748810 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 748817..749785 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 748817..749785 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 749809..750720 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 749809..750720 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 750598..750607 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750620..750639 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 750623 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 750749..751927 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 750749..751927 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 751468..751474 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751489..751508 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751503 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 751928..752863 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 751928..752863 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 752735 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 752845 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(752886) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(752894..754123) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(752894..754123) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(754152..754171) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(754170) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(754187..754194) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(754234..754941) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(754234..754941) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(754263) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(754964..754983) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(754987) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(755033..756418) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(755033..756418) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(755055) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(756467..756486) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(756484) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(756501..756508) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 756586..756593 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 756601 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 756607..756625 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 756668..758125 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 756668..758125 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(757461..757480) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(757475) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(757493..757502) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 758139..758999 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 758139..758999 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 758983 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 759067..759074 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759088..759107 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 759093 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 759134..761023 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 759134..761023 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 761007 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 761087..761106 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 761095 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 761146..761592 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 761146..761592 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(761148) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(761232..761235) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(761237) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(761253..761254) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 761579 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 761655..761662 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761676..761695 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761688 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 761717..762139 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 761717..762139 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 761975 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 762205..763395 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 762205..763395 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(763459) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 763686..763841 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 763686..763841 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(763961..765517) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(763961..765517) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(763985) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 765347..765353 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765368..765379 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765385 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(765567..765586) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765571) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765602..765606) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 765627..765630 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765646..765665 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765649 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 765690..766820 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 765690..766820 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 766803 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 766888..767334 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 766888..767334 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(767387..768406) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(767387..768406) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(767397) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(768427..768446) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768431) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768433..768887) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(768459..768466) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768525..768532 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768546..768565 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 768553..769650 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 768553 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(768888..770108) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(768888..770108) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(770145..770164) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(770152) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(770180..770187) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 770206..770213 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 770225..770400 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 770225 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 770228..770247 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 770357 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 770444..771907 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 770444..771907 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(770809..772479) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 771908..772401 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 772389..772394 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 772403..775668 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 772403 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 772410..772428 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(772480..773280) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(772480..773280) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(773293..774294) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(773293..774294) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(773880..773899) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(773892) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(773914..773921) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(774291..775292) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(774291..775292) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(775362..775381) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(775364..776311) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(775364..776311) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(775383) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(775383) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 775638..775643 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 775659..775677 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 775670..776295 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 775670 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 776291..776310 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 776297..776828 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 776297 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(776353..776372) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776360) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776386..776393) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(776420..776788) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(776420..776788) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(776789..776901) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(776890..776909) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(776901) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(776921..776928) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 776969..776975 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 776989..777007 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 776989 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 777032..777379 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 777032..777379 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(777033) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 777375 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 777420..777500 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 777501..777520 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 777502 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 777570..778832 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 777570..778832 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 778827 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 778885..778888 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778903..778922 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778911 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 778959..780395 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 778959..780395 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 780387 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 780486..780505 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 780497 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 780522..782150 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 780522..782150 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 782122..782802 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 782122..782802 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 782805..783764 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 782805..783764 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 783733 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 783856..783863 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783876..783895 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 783887..783959 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 783887 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 783960..785261 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 783960..785261 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 785258..785264 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 785278..785289 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 785279 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 785317..786111 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 785317..786111 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 786087 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 786166..786169 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786184..786203 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786197 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 786230..787321 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 786230..787321 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(787312..787587) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(787312..787587) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 787322..787653 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(787601..787620) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(787615) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(787635..787642) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 787654..788319 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 787654..788319 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(788360..788497) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(788360..788497) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(788374) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(788498..788628) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(788614..788632) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 788624..788629 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(788628) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 788639..789703 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 788640 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 788645..788663 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(788648..788653) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(788654..788809) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(788654..788809) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(788810..788915) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(788916..789230) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(788916..789230) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(789231..789311) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(789312..790061) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(789312..790061) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(790090..790109) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(790103) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(790105..791241) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(790121..790129) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 790172..790173 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790193..790212 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790196 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 790233..791591 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 790233..791591 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(791227..791246) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(791241) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(791260..791269) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 791477 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 791587 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(791624..793573) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(791624..793573) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(791641) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 792683..792689 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 792705..792723 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 792709..793673 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 792709 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(793574..793648) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(793625..793644) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793648) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(793650..794172) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(793660..793664) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 793674..793811 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 793674..793811 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 793789 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 793790..793809 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 793830..794222 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 793830..794222 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(794170..794188) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(794185) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(794204..794209) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 794291..794297 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794312..794330 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794312 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 794347..795762 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 794347..795762 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(794348) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(794374..794474) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(794414) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(795759..796835) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(795759..796835) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 795763..799129 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(796859..797059) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(796859..797059) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(797075..798229) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(797075..798229) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(798210..799751) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(798210..799751) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(799801..799812) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799804) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(799826..799832) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 799861..799868 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799883..799902 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799890 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(799936) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 799944..801356 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 799944..801356 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(799962..800062) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(800002) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 801427..803112 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 801427..803112 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(801733..801748) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(801740) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(801761..801770) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 803085..803089 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803105..803124 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803108 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 803133..803849 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 803133..803849 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 803842 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 803924..803927 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803943..803962 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803952 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 803989..804654 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 803989..804654 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 804635 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(804691..809079) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(804691..809079) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(804710) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(809112..809131) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(809129) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(809146..809149) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 809256..809262 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 809276..809294 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 809279 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 809322..809840 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 809322..809840 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 809826 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(809870) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 809871..811521 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(809880..811070) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(809880..811070) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(811071..811162) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(811163..811378) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(811163..811378) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(811222) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(811410..811429) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811424) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(811444..811445) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 811491..811498 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811513..811532 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811523 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 811581..812051 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 811581..812051 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 812069..812389 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 812069..812389 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 812413..813240 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 812413..813240 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 813219..813225 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 813240..813251 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 813258..813414 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 813258 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(813290) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 813389 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(813439..814614) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(813439..814614) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(813444) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 814051..814057 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 814073..814091 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 814077..814730 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 814077 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(814639..814658) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814654) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814672..814679) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 814720..814725 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 814732 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 814740..814758 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 814782..815837 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 814782..815837 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 815851..815857 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 815872..815883 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 815876 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 815908..816702 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 815908..816702 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 816690 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(816741..817583) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(816741..817583) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(816743) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(817584..818705) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(817584..818705) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(818746..818765) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818764) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818781..818785) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 818793..818800 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818814..818833 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818824 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 818850..819035 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 818850..819035 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 819014 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 819078..819084 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 819090 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 819099..819110 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 819136..819927 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 819136..819927 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 819925 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(819965..820825) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(819965..820825) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(819979) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(820845..820864) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(820859) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(820880..820883) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(820924..821883) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(820924..821883) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(820947) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(821894..821913) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(821897) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(821929..821932) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 821944..821948 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821962..821981 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821971 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 822002..822865 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 822002..822865 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 822866..822978 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 822979..824379 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 822979..824379 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 824391 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 824685..824692 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824708..824727 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824714 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 824721..825004 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 825005..825271 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 825005..825271 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(825219..825238) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(825237) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(825253..825256) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 825272..825753 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 825724..825727 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825744..825763 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 825755..826002 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 825755 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 826003..826980 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 826003..826980 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 826981..827073 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 827030 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 827114..827120 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827132..827151 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 827141 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 827176..827628 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 827176..827628 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 827658..828347 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 827658..828347 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 828352 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 828524..828542 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 828531 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 828579..829580 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 828579..829580 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 829584..830612 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 829584..830612 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 830626..831822 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 830626..831822 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(830627) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 831843..833219 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 831843..833219 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 833213 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 833266..833273 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 833286..833305 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 833294 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 833335..835152 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 833335..835152 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 835153..835159 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 835171 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 835174..835185 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 835206..835385 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 835206..835385 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 835369 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(835421..835750) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(835421..835750) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(835435) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(835800..836258) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(835800..836258) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(836259..836351) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(836352..836909) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(836352..836909) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 836775..836780 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 836788 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 836795..836813 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 836799..837386 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(836941..837708) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(836941..837708) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(837720..838943) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(837720..838943) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(838949..839263) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(838949..839263) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(839311..839330) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(839324) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(839345..839348) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 839555..839574 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 839558 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 839599..840948 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 839599..840948 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 840977..840996 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 840979 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 841013..841777 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 841013..841777 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(841157..841171) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(841187..841193) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(841187) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 841792..843375 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 841792..843375 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 843355 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 843404..843411 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 843426..843445 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 843434 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 843481..845202 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 843481..845202 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 845196..847010 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 845196..847010 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 846985 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 847092..847099 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 847113..847132 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 847117 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 847165..847569 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 847165..847569 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 847587..848444 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 847587..848444 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 848431 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 848538..849482 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 848538..849482 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(849349) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(849397..849497) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(849437) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 849657..851105 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 849657..851105 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 851132..852073 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 851132..852073 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 852083..853264 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 852083..853264 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 853254 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 853324..853330 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 853345..853364 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853363 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 853388..854590 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 853388..854590 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 854587..855249 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 854587..855249 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 855257 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 855393..856328 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 855393..856328 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 856341..857531 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 856341..857531 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 857545..858702 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 857545..858702 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 857656..857661 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 857676..857694 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 857677 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(858700..858774) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(858743) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(858775..859323) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(858775..859323) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(859324..859403) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(859392..859411) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859403) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859425..859430) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 859526..859529 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859545..859564 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859552 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 859596..860228 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 859596..860228 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 860207 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 860343..860348 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860362..860381 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860372 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 860417..861505 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 860417..861505 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(860907..861295) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(861295) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(861297..861316) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(861329..861337) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(861541..862158) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(861541..862158) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(861559) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(862124..863377) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(862124..863377) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(862185..862204) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(862197) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(862218..862225) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(863411..863430) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(863429) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(863445..863452) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 863456..863475 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 863461 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 863501..864037 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 863501..864037 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(864034..865590) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(864034..865590) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(865612..865630) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(865629) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(865646..865649) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(865701..866183) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(865701..866183) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(865717) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(866208..866227) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866224) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866242..866248) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 866269..866276 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866290..866309 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866298 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 866355..868925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 866355..868925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 868896 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(868943..869920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(868943..869920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(868954) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 869935..869942 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(869947..869966) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 869957..869976 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 869959..870050 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 869959 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(869964) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(869981..869988) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 870051..871052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 870051..871052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 871049..872080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 871049..872080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 872061 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 872131..872133 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872149..872168 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872152 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 872195..873076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 872195..873076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 873087..873094 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 873110..873129 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 873119 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 873164..873748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 873164..873748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 873735 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(873787..873978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(873787..873978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(873805) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(874010) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(874013..874024) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(874039..874045) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(874045..874155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(874045..874155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(874184..874195) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(874186) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(874210..874216) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(874210..875121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(874210..875121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 875007..875010 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875027..875046 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 875037..875209 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 875037 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(875143..875161) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(875157) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(875175..875181) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 875210..876004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 875210..876004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 876006..876320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 876006..876320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(876228..876496) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 876310 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 876394..876399 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876415..876434 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 876420 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 876463..877656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 876463..877656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 877657..877891 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(877689..877841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(877689..877841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(877706) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 877870..877877 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877891..877910 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 877893..877965 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 877893 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(877900..877911) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(877910) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(877926..877932) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 877966..878235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 877966..878235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 878224 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 878313..878319 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 878334 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 878335..878353 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 878380..878898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 878380..878898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 878899..878966 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 878934..878943 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 878955..878970 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 878968 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 878983..879315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 878983..879315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 879302..880162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 879302..880162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 880160 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 880220..880226 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 880240..880251 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 880248..880312 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 880248 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(880270..880289) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(880279) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 880295..880301 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(880303..880304) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 880314..880394 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 880314 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 880316..880334 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 880395..881384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 880395..881384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(880544) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(880549..880553) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(880570..880574) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 881385..881455 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 881456..884041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 881456..884041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 884010 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(884034..885017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(884034..885017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(884068) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 884491..884500 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 884513..884532 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 884517 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(885018..885165) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 885122..885126 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885142..885161 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885149 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 885155..885232 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(885163..885182) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(885165) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(885197..885204) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 885233..886342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 885233..886342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 886179..886183 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 886199..886218 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 886211 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 886343..886655 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(886350..886574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(886350..886574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(886604..886615) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886606) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(886629..886635) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 886656..887408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 886656..887408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 887425..887431 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887446..887457 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887447 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(887454..887468) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(887475) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(887477..887481) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 887477..887731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 887477..887731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 887729 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(887754) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 887820..888164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 887820..888164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 887827..887835 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887846..887864 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887848 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 888147 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 888203..888210 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 888224..888243 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 888233..888307 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 888233 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 888308..888838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 888308..888838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 888829 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 888926..890668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 888926..890668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 890655 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(890745..891806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(890745..891806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(890756) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(891807..891897) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(891895..891914) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891904) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891929..891936) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(892026..893315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(892026..893315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(892029) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(893343..893362) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(893362) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(893364..894075) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(893374..893379) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 893408..893415 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 893429..893448 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893429 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 893468..893941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 893468..893941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 893978..893985 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894000..894019 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894006 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 894064..894501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 894064..894501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 894483 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(894536..894889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(894536..894889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 894549 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(894559) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 894885..894889 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 894897..894911 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(894901..894920) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 894901..894992 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 894901 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(894911) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 894969..894972 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 894987..895006 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 894994..895096 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 894994 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 895097..895981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 895097..895981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 895964..895971 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 895985..896004 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 896000..896272 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 896000 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(896033) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 896273..897827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 896273..897827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 897995..900922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 897995..900922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 900923..901008 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 900984..900991 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901005..901024 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901010 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 901034..901149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 901034..901149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 901159..901233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 901159..901233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 901239..901330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 901239..901330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 901326 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 901365..901436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 901365..901436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 901446..901521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 901446..901521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 901531..901607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 901531..901607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 901619..901695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 901619..901695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 901708..901783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 901708..901783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 901789..901861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 901789..901861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 901884..901968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 901884..901968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 901974..902047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 901974..902047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 902072..902147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 902072..902147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 902157..902228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 902157..902228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 902278..902352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 902278..902352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 902358..902428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 902358..902428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 902436..902524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 902436..902524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 902525..902601 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 902558 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 902603..902771 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 902728..902735 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 902734 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 902749..902768 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 902773 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 902790..902871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 902790..902871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(902807..902824) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(902810) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(902845..902850) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(902880) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(902950..903726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(902950..903726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(902964) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(903753..903768) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(903775) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(903781..903790) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 903810..903816 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 903831..903842 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 903834 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 903868..904071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 903868..904071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 904054 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(904130) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(904156..904428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(904156..904428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(904387..904405) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(904394) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 904409..904416 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(904422..904427) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904429..904448 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 904437 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 904470..905162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 904470..905162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 905191..905195 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(905194..905213) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(905206) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 905209..905228 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(905228..905235) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 905232..905339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 905232..905339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 905239 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 905370 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 905472..907244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 905472..907244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 907220 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 907265..908190 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(907282..908637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(907282..908637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(908665..908684) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908682) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(908698..908707) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908755..908761 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908776..908795 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908804 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 908888..909085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 908888..909085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(909112..910563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(909112..910563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(909122) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 910540..910546 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 910561..910580 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 910564 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(910581..910600) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 910586..910915 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(910600) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(910614..910621) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(910659..910677) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(910684) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 910872 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 910971..911738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 910971..911738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 911756..912754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 911756..912754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 912751..913581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 912751..913581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 913604..914734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 913604..914734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 914761..914780 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 914767 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 914838..915374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 914838..915374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 915375..915445 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 915415..915422 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 915436..915455 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915447 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 915486..915755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 915486..915755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 915558..915562 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 915585..915601 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915601 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 915742 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(915773..916246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(915773..916246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(915809) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(916248..916448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(916248..916448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(916477..916496) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916491) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916509..916516) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 916572..916577 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916591..916610 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916591 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 916642..916715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 916642..916715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 916716..916898 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(916806..917429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(916806..917429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(916821) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 916855 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 916900..917511 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(917453..917472) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917474) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(917486..917493) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 917512..918672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 917512..918672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 918681 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 918698..918710 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 918703 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 918739..919674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 918739..919674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(918757) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 919658..919661 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 919676 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 919677..919696 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 919712..920194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 919712..920194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 920177 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 920244..920960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 920244..920960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 920264..920271 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920286..920305 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 920287 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 920951..921664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 920951..921664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 921676..922383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 921676..922383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 922267 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 922311 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 922377 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(922410..922585) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(922453) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(922577..922596) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(922585) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(922611..922618) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 922650..922655 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922671..922689 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922671 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 922733..924628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 922733..924628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 923175..923275 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 923235 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 923301 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 924621 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 924685..924690 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 924706..924724 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 924709..924807 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 924709 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 924808..925986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 924808..925986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 925006..925009 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925024..925043 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 925028 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(925269) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 925965 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 926073..926080 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926095..926114 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926095 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 926146..926610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 926146..926610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 926435..926441 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926456..926474 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926469 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 926619..926625 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926639..926650 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926645 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 926646..927311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 926646..927311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 927352..928950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 927352..928950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 928973..929503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 928973..929503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 929516..929890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 929516..929890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 929879 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 929890..930045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 929890..930045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 929980..929986 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 930001..930020 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 930011 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 930050..930811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 930050..930811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(930363..930381) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(930377) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(930397..930402) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 930814..931179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 930814..931179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 931181..931879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 931181..931879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 931896..932813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 931896..932813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 932806..933747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 932806..933747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 933729 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(933839..934042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(933839..934042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(933853) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(934043..934170) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 934130..934141 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 934147 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(934159..934178) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(934170) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(934172..935310) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(934192..934197) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 934337..934344 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 934359..934377 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 934366 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 934367..934477 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 934478..935308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 934478..935308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 935267 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(935311..936390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(935311..936390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(936400..936419) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(936421) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(936435..936439) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 936497..936504 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936518..936537 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936524 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 936563..937954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 936563..937954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(937590..937993) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 937933 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(937994..938449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(937994..938449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(938464..938482) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938492) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938497..938503) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 938541..938547 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938561..938572 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 938565 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 938599..939168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 938599..939168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 938795..938801 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 938812 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 938815..938826 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 939143 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 939211..939220 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939234..939253 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939244 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 939289..940257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 939289..940257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 940133 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(940189..940842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(940189..940842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(940206) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(940873..940884) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(940875) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(940899..940905) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 940914..940922 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 940925..944578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 940925..944578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 940933..940951 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 940948 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 944575..945171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 944575..945171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 945150 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(945201..946109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(945201..946109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 946165..946173 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(946166..946177) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(946172) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(946174..946660) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 946184 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 946187..946206 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(946191..946197) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 946220..946615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 946220..946615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(946646..946665) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(946660) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 946700..946706 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 946715 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 946720..946731 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(946730..946744) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(946744) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(946752..946756) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 946752..947174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 946752..947174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(947078..947178) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(947118) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 947152 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(947184) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 947224..947231 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947245..947264 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947253 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 947301..947963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 947301..947963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 947979..949520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 947979..949520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 949503 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 949604..949795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 949604..949795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 949826..949833 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 949848..949867 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 949859..949940 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 949859 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 949941..951293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 949941..951293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 951321..951899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 951321..951899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 951894..951901 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951916..951935 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951927 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 951942 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 951987..952077 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 952078..952902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 952078..952902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 952921..954411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 952921..954411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 953722..953728 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 953743..953762 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 953753 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 954412..954500 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 954457 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 954463..954563 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 954523 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 954552..956219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 954552..956219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 955981..955986 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 956001..956019 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 956010 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 956064..956070 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956085 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956086..956104 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 956187 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 956232..956305 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 956287..956294 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956307 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956308..956327 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 956351..958096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 956351..958096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 958085 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 958130..958199 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 958201..958220 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 958201 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 958245..959384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 958245..959384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 959381..960025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 959381..960025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 960022..960546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 960022..960546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 960511 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(960561..960803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(960561..960803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(960582) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(960839..960850) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(960850) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(960864..960871) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 960938..960944 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 960958..960969 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 960968 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 961004..961327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 961004..961327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 961328..963194 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(961369..962835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(961369..962835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(961381) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(961468) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(962875..962893) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(962887) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(962907..962914) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(962988..963428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(962988..963428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(963018) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 963416..963422 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963436..963447 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 963438..963548 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 963438 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(963450..963469) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963466) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963481..963487) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 963507 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(963535..965193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(963535..965193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(963540) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(965084..965102) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(965104) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(965116..965122) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 965165..965170 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965186..965204 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965199 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 965224..966630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 965224..966630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 966610 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(966660..968045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(966660..968045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(966686) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(968072) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(968074..969605) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(968082..968093) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 968201..968208 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968221..968240 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 968227..968514 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 968227 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 968477..968480 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968495..968514 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 968516 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 968575..969579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 968575..969579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 969441 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 969571 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(969605) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(969612..969627) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 969617 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(969639..969648) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(969650..970525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(969650..970525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 970578..970579 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(970591..970610) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 970596..970615 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(970597) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 970606 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(970625..970630) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 970634..971734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 970634..971734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 971745..971751 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 971766..971784 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 971771 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 971808..972677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 971808..972677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 972685 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 972762..972765 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 972777 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 972780..972799 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 972825..972844 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 972830..972926 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 972830 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 972927..974324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 972927..974324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 974304 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 974385..974389 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974405..974424 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974412 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 974442..975797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 974442..975797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 975778 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(975832..977241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(975832..977241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 977290..977293 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977308..977327 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977310 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(977312..977331) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977324) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977347..977351) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 977351..977779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 977351..977779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 977758 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(977810..978100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(977810..978100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(977834) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(978088..979164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(978088..979164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(979154..979645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(979154..979645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(979646..979748) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(979737..979756) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979748) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979770..979773) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 979786..979792 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 979803 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 979807..979825 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(979836) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 979842..980837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 979842..980837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 980816 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 980899..980902 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980917..980936 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980922 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 980972..981571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 980972..981571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 981586 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 981631..983585 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(981640..982974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(981640..982974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(981659) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(983035..983466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(983035..983466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(983478..983497) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983488) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983512..983518) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(983514..983614) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 983549..983556 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(983554) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 983570..983589 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 983587 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 983623..984804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 983623..984804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 984789 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 984834..984972 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 984968..984987 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 984974..985130 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 984974 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 985131..986516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 985131..986516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 986406 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 986492 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(986530..986886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(986530..986886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(986883..987278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(986883..987278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(987265..987996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(987265..987996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(988021..988040) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(988042) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 988089..988097 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988106 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988111..988126 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 988120..988193 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 988180..988181 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988195 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988197..988216 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 988230..988337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 988230..988337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 988338..988391 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 988362 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 988442..988461 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 988448 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 988486..989601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 988486..989601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 989581 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 989638..989657 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 989638 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 989671..990414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 989671..990414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 990386 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(990438..991286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(990438..991286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(990462) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 991282..991287 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(991287..991386) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 991303..991321 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991305 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 991310..991505 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(991375..991394) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(991389) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(991409..991412) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 991504..991523 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 991507..991570 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 991507 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 991571..992419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 991571..992419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 992410 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(992462..993823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(992462..993823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(992486) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(993824..993894) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(993867..993886) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(993894) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(993950..994450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(993950..994450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(993982) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(994472..994490) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(994492) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(994505..994511) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 994529..994536 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 994544..994613 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 994545 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 994551..994570 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 994614..994775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 994614..994775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 994705 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 994776..994894 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 994895..996652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 994895..996652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 996649..998670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 996649..998670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 998658 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(998719..999339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(998719..999339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(998734) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 999324..999424 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(999353..999372) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999368) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(999378..999503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(999378..999503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 999384 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999387..999390) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(999517..999536) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999526) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999550..999559) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 999582 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(999608..999811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(999608..999811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(999613) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(999812..999922) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 999852..999952 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 999912 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(999928) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(999932..999943) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(999958..999964) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000020..1000238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(1000020..1000238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(1000054) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1000279..1000298) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000296) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1000312..1000319) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000388..1001749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(1000388..1001749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(1000406) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1000450) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1001739..1002830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(1001739..1002830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(1002154..1002168) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002166) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002182..1002190) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1002831..1002936) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(1002920..1002938) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002940) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002954..1002959) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1003002..1003009 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1003024..1003043 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1003035 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 1003097..1004230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 1003097..1004230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 1004231..1004322 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 1004323..1004676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 1004323..1004676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 1004664 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1004720..1005793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(1004720..1005793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(1004827) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1005815..1005834) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005827) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005848..1005855) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1005930..1005937 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1005950 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1005952..1005971 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1005961..1006114 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 1006071 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 1006116..1006199 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 1006156 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 1006212..1006217 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1006233..1006251 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1006242 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1006279..1007145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 1006279..1007145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 1007127 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1007190..1007193 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1007208..1007227 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007216 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1007257..1008762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 1007257..1008762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 1008732 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1008780..1009997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(1008780..1009997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(1008786) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1010004..1010501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(1010004..1010501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(1010565..1010903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(1010565..1010903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(1010915..1010934) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1010939) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1010948..1010955) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1010975..1010982 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1010997..1011016 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1011007 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 1011068..1011835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 1011068..1011835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 1011836 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1011856..1012041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(1011856..1012041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(1012077..1012095) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1012088) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1012106..1012114) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1012115..1012118 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1012133..1012152 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1012143 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 1012168..1013064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 1012168..1013064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 1013057..1014316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 1013057..1014316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 1014300 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1014364..1014371 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1014383..1014402 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1014388 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1014423..1015649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 1014423..1015649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(1015124) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 1015654..1018545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 1015654..1018545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 1016935..1016940 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1016956..1016974 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1016962 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1018553..1018558 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018573..1018592 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018588 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1018619..1019563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 1018619..1019563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 1019541 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 1019622..1019627 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019643..1019661 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019646 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 1019688..1019900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 1019688..1019900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 1019893 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(1019931) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1019941..1020819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(1019941..1020819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(1020129) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1020857..1020876) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020881) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1020890..1020897) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1020917..1020926 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1020938 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1020939..1020958 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1020975..1020989) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020976) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1020979..1021065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 1020979..1021065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(1020998..1021002) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1021066..1021317 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 1021190..1021276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 1021190..1021276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 1021274 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(1021286..1021548) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 1021319..1021802 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(1021329) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1021541..1021560) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021548) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1021550..1021618) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(1021574..1021579) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1021619..1022137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(1021619..1022137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 1021924..1021932 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1021944..1021962 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1021957 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1022168..1022187) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022186) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022203..1022209) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022286..1022289 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022304..1022323 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022309 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 1022345..1022686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 1022345..1022686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(1022540..1022682) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(1022583) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1022683..1023294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(1022683..1023294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 1022687..1023452 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(1022759) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 1023290..1023294 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023302..1023315 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023314 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1023319..1023338) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(1023342) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(1023353..1023356) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 1023409 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1023472..1023828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(1023472..1023828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(1023476) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1023905..1023910 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1023911..1023930) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1023925) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1023926..1023944 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023926 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1023927..1024190) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 1023958..1024149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 1023958..1024149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 1024150..1025585 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(1024223..1024741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(1024223..1024741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(1024235) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(1024742..1024829) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(1024821..1024840) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1024829) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1024854..1024861) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1024866..1025945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(1024866..1025945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(1025984..1026003) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1025995) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1025997..1026078) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1026092..1026529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(1026092..1026529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(1026123) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1026562..1026581) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026576) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 1026579 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(1026595..1026602) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1026601..1026897) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1026644) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1026895..1026906) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026901) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1026921..1026927) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1026957..1026964 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1026978..1026997 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1026987 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 1027017..1027760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 1027017..1027760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 1027753..1028979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 1027753..1028979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(1028312..1028330) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1028327) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1028346..1028351) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1028999..1029709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 1028999..1029709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 1029673 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1029727..1030917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(1029727..1030917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(1029737) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1029802) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1030941..1030960) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1030962) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1030974..1030979) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1030990..1032381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(1030990..1032381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(1032392..1032411) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032397) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1032424..1032433) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1032447..1032761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(1032447..1032761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(1032806..1033306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(1032806..1033306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(1032833) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1033319..1033338) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1033321..1033325 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1033340) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1033341..1033360 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033342 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033355..1033356) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1033373..1033379 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1033394..1033405 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033399 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 1033428..1035572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 1033428..1035572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(1033472..1033483) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033475) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033497..1033503) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1035609..1035615 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1035629..1035648 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1035639 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 1035694..1036755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 1035694..1036755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 1036827..1037759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 1036827..1037759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 1037774..1039186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 1037774..1039186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 1037777 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1039163 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1039247..1039254 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1039268..1039287 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1039273 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 1039332..1039907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 1039332..1039907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 1039651..1039654 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1039669 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1039671..1039690 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1039908..1039977 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1039978..1042305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 1039978..1042305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 1042287 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1042347..1043324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(1042347..1043324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(1042360) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1043338..1043357) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043356) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1043371..1043377) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1043383..1043391 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043402..1043420 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043409 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1043451..1044227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 1043451..1044227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(1043943..1044564) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1044228..1044599 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1044542..1044561) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1044563) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1044575..1044584) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044577..1044584 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1044599..1044618 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1044601 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1044640..1045680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 1044640..1045680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 1045693..1046100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 1045693..1046100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 1046071 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(1046137..1047426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(1046137..1047426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(1046167) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1047427..1047527) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1047526..1047545) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047527) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1047529..1047665) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1047560..1047566) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1047697..1047837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1047697..1047837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1047710) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1047856..1047875) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047875) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1047888..1047895) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1047919..1047925 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1047939..1047958 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1047942 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1047989..1048723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1047989..1048723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1048736..1049731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1048736..1049731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1049796..1050440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1049796..1050440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1050428 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1050468..1050471 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050486..1050505 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1050493 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1050557..1052098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1050557..1052098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1052078 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1052137..1052532) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1052137..1052532) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1052154) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1052552..1052563) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052556) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1052578..1052584) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1052617..1052620 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1052628 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1052635..1052654 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1052681..1053961 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1052681..1053961 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1053108..1053127) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053122) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1053143..1053148) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1053948 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1053998) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1054000..1055145) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1054000..1055145) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1055146..1055212) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1055201..1055220) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1055218) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1055236..1055240) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1055525..1055532 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1055547..1055566 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1055549 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1055580..1056029 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1055580..1056029 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1056045..1056052 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1056067..1056086 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1056074 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1056101..1057093 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1056101..1057093 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1057094 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1057139..1057249 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1057227..1057234 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057250..1057269 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057251 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1057310..1058281 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1057310..1058281 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1058260 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058313..1058894) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1058313..1058894) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1058336) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1058918..1058937) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1058930) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1058953..1058956) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1058965..1060059) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1058965..1060059) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1060056..1061495) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1060056..1061495) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1061502..1062062) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1061502..1062062) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1061512..1061531) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1061526) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1062087..1062106) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1062101) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1062121..1062128) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1062197..1063495) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1062197..1063495) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1062208) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1063549..1063567) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063552) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1063581..1063587) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063634..1065163) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1063634..1065163) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1065190..1065208) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065200) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1065219..1065224 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1065223..1065228) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1065236 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1065240..1065258 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1065275..1066132 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1065275..1066132 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1066114 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1066160..1066393) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1066160..1066393) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1066193) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1066410..1066429) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1066413..1066414 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1066413 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1066417..1066432 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1066432) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1066434..1067289) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1066444..1066451) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1066616..1066623 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1066635..1066654 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1066641 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1066686..1067264 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1066686..1067264 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1067265..1067410 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1067311..1068210) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1067311..1068210) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1067334) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1067397..1067400 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1067412 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1067418..1067422 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1067456 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1067501..1068367 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1068237..1068255) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1068254) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1068270..1068276) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1068344..1068351 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068366..1068385 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068369 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1068427..1068696 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1068427..1068696 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1068688 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1068736) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1068739..1070208) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1068739..1070208) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1070205..1070405) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1070205..1070405) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1070406..1070524) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1070507..1070526) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1070524) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1070539..1070546) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1070612) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1070613..1070975) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1070613..1070975) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1070813..1070818 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070834..1070852 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070835 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1070844..1071083 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1071005..1071024) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071023) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1071039..1071046) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1071065..1071072 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1071085 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1071086..1071105 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1071127..1071750 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1071127..1071750 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1071752..1072258 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1071752..1072258 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1072251 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1072309..1072316 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072330..1072349 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1072339..1072438 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1072339 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1072439..1073938 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1072439..1073938 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1073946..1073953 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1073965 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1073967..1073986 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1074015..1074542 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1074015..1074542 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1074504 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1074556..1074699) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1074594) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1074700..1075905) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" /label="glcP CDS" gene complement(1074700..1075905) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /label="glcP gene" promotor_-35 1075395..1075400 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1075417..1075435 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1075420..1075946 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1075421 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="upshifts" downshifts 1075904 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1075977..1077029) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" /label="ntdC CDS" gene complement(1075977..1077029) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /label="ntdC gene" CDS complement(1077043..1077891) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" /label="ntdB CDS" gene complement(1077043..1077891) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /label="ntdB gene" CDS complement(1077863..1079188) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" /label="ntdA CDS" gene complement(1077863..1079188) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /label="ntdA gene" promotor_-35 1078032..1078037 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1078053..1078071 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1078059..1078847 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1078059 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="upshifts" promotor_-35 1078823..1078830 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1078845..1078864 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1078849..1079291 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1078849 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1079223..1079242) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1079235) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1079256..1079263) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1079292..1080281 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" /label="ntdR CDS" gene 1079292..1080281 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /label="ntdR gene" S_feature 1080282..1080659 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1080336..1080494) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1080379) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1080495..1081649) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1080495..1081649) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1081650..1081721) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1081704..1081723) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1081720) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1081737..1081742) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1081756..1082961) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1081756..1082961) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1082982..1083001 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1082987 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1083075..1084802 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1083075..1084802 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1084388..1084395 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1084410..1084429 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1084417 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1084832..1085158) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1084832..1085158) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1085276..1085713) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1085276..1085713) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1085285) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1085744..1085763) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085764) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1085776..1085785) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1085833..1085840 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1085854..1085873 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085866 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1085897..1089397 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1085897..1089397 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1089384..1093082 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1089384..1093082 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1093083..1093153 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1093154..1094329 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1093154..1094329 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1094326..1097718 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1094326..1097718 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1096973..1096979 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1096994..1097005 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1097001 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1097070..1098043) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1097732..1098034 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1097732..1098034 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1098014 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1098071..1098289) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" /label="gerPF CDS" gene complement(1098071..1098289) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /label="gerPF gene" downshifts complement(1098088) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" CDS complement(1098321..1098722) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" /label="gerPE CDS" gene complement(1098321..1098722) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /label="gerPE gene" CDS complement(1098722..1098898) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" /label="gerPD CDS" gene complement(1098722..1098898) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /label="gerPD gene" CDS complement(1098895..1099512) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" /label="gerPC CDS" gene complement(1098895..1099512) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /label="gerPC gene" CDS complement(1099535..1099768) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" /label="gerPB CDS" gene complement(1099535..1099768) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /label="gerPB gene" CDS complement(1099783..1100004) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" /label="gerPA CDS" gene complement(1099783..1100004) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /label="gerPA gene" S_feature complement(1100005..1100091) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1100019..1100025 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1100039..1100058 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1100041..1100696 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1100041 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1100078..1100097) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1100091) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1100093..1100222) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1100110..1100119) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1100224..1100426) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1100267) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1100427..1100597) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" /label="pchI CDS" gene complement(1100427..1100597) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /label="pchI gene" misc_feature complement(1100641..1100660) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1100644) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1100646..1100742) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1100653 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 1100698..1100862 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1100743..1101666) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" /label="yisJ CDS" gene complement(1100743..1101666) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /label="yisJ gene" promotor_-10 complement(1101688..1101707) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1101699) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="upshifts" promotor_-35 complement(1101721..1101730) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1101750..1101758 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1101770..1101788 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1101775 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="upshifts" CDS 1101821..1102726 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" /label="mblK CDS" gene 1101821..1102726 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /label="mblK gene" S_feature 1102727..1102807 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1102777..1102780 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1102797..1102816 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1102809 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="upshifts" CDS 1102842..1103198 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" /label="yisL CDS" gene 1102842..1103198 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /label="yisL gene" downshifts 1103095 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 1103186 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" /label="downshifts" upshifts 1103319 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1103322..1103341 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1103366..1106050 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" /label="wprA CDS" gene 1103366..1106050 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /label="wprA gene" downshifts complement(1103534) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" /label="downshifts" downshifts 1106042 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1106081..1106668) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1106081..1106668) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1106683..1106702) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1106702) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1106718..1106720) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1106723..1106729 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1106741 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1106744..1106762 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1106747..1106813 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1106814..1108658 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1106814..1108658 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1108659..1108726 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1108683 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1108788..1109267) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1108788..1109267) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1109287) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1109291..1109309) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1109320..1109328) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1109459..1109463 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1109476 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1109478..1109497 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1109499..1110323 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1109499..1110323 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1109711..1109717 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1109732..1109750 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1109739 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1110333..1111783 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1110353..1111720) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1110353..1111720) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1111752..1111759 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111773..1111792 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1111785 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1111844..1112707 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1111844..1112707 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1112725..1113738 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1112725..1113738 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1113721 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1113790..1113797 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1113812..1113831 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1113831..1113946 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1113831 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1113947..1114975 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1113947..1114975 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1114997 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1115026..1115535) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1115026..1115535) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1115045) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1115548..1115566) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115564) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115578..1115586) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1115585..1116247) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1115585..1116247) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1116266..1116272 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1116286..1116305 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1116295 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1116314..1117768 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1116314..1117768 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1117623..1117775) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1117658) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1117776..1118414) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1117776..1118414) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1118415..1118549) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1118463..1118468 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118484..1118502 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118485 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1118495..1118619 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1118535..1118554) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118549) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1118569..1118576) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1118620..1119426 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1118620..1119426 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1119419 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1119454..1120053) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1119454..1120053) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1119473) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1120050..1121219) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1120050..1121219) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1121220..1121331) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1121332..1122042) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1121332..1122042) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1122086..1122105) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1122108) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1122118..1122127) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1122157..1122166 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1122180..1122199 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1122191 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1122227..1122913 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1122227..1122913 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1122910..1123668 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1122910..1123668 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1123665 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1123713..1124342) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1123713..1124342) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1124376..1124394) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1124393) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1124409..1124414) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1124438..1125553) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1124438..1125553) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1124467) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1125562..1126830) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1125562..1126830) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1126856..1126867) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1126865) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1126881..1126887) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1126942..1127790) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1126942..1127790) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1126953) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1127795..1128244) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1127795..1128244) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1128265..1128284) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1128279) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1128300..1128301) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1128334..1130172) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1128334..1130172) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1128361) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1130254) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1130262..1130379) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1130262..1130379) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1130431..1130450) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1130445) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1130465..1130472) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1130486..1130977) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1130486..1130977) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1130995..1130998 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1131001..1131020) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1131013..1131032 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1131014 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1131019) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1131035..1131042) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1131076..1131972 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1131076..1131972 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1131959 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132025..1132609) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1132025..1132609) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1132035) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132606..1133535) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1132606..1133535) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1132693) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1133520..1134056) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1133520..1134056) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1134092..1134111) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1134106) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1134126..1134129) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1134197..1134204 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1134219..1134238 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1134222 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1134234..1134581 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1134234..1134581 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1134578..1135165 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1134578..1135165 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1135185..1135478 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1135185..1135478 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1135458 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1135502 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1135614..1137230 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1135614..1137230 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1137218 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1137277..1138128) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1137277..1138128) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1137294) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1137675..1137682 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1137697..1137716 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1137702..1138227 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1137704 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1138169..1138188) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138192) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1138206..1138211 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1138226..1138244 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138229 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1138266..1139108 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1138266..1139108 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1138761..1138769 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1138780..1138798 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138780 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1139109..1139222 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1139223..1139582 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1139223..1139582 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1139571 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1139613..1139810) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1139613..1139810) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1139626) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1139811..1140007) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1140007) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1140009..1140020) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1140035..1140041) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1140067..1140879) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1140067..1140879) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1140917..1140936) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1140937..1140944 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1140937) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140950..1140957) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140956..1140975 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1140958 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1141000..1141767 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1141000..1141767 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1141776..1141782 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1141796 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1141797..1141816 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1141831..1142139 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1141831..1142139 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1142124 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1142169..1142434 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1142435..1143865 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1142435..1143865 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1143910..1144404 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1143910..1144404 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1144368 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1144542..1144549 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1144548 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1144563..1144582 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1144611..1145648 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1144611..1145648 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1145668..1146888 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1145668..1146888 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1146903..1147679 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1146903..1147679 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1147676..1148833 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1147676..1148833 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1148904..1149959 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1148904..1149959 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1149514,1149515) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1149793..1149812) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1149803) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1149952..1153044 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1149952..1153044 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1153032..1153991 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1153032..1153991 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1153954 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1153994..1154268) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1154019..1154025 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1154027) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1154040..1154051 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154061 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1154077..1154256 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1154077..1154256 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1154266 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1154302..1154487) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1154302..1154487) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1154313) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1154516..1154535) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1154533) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1154546..1154553) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1154588..1154594 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1154606..1154625 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154611 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1154668..1154677 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1154677 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1154690..1154709 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1154736..1155470 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1154736..1155470 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1155229..1155831) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1155451..1155456 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1155469 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1155469 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1155472..1155490 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1155552..1156109 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1155552..1156109 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1155811..1155830) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155831) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155845..1155849) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1156116..1156123 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1156138..1156157 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1156150 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1156200..1157153 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1156200..1157153 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1156817..1156821 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1156837..1156856 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1156850 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1157168..1157359 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1157168..1157359 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1157338 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1157383..1157723 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1157389..1157628) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1157389..1157628) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1157405) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1157641..1157660) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157662) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157674..1157683) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1157689..1157696 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1157711..1157730 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1157725 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1157793..1158731 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1157793..1158731 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1157870..1157879 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1157888 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1157891..1157906 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1158754..1159995 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1158754..1159995 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1158968..1158986) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158976) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1159002..1159007) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1159846 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1159979 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1160020..1160029 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1160042..1160061 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1160044 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1160056..1160064 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1160071..1160856 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1160071..1160856 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1160076..1160094 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1160088 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1160857..1160941 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1160873..1160891) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1160890) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1160906..1160911) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1160909..1160916 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1160931..1160950 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1160943..1161047 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1160943 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1161048..1162034 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1161048..1162034 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1162031..1163020 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1162031..1163020 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1163026..1163032 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1163031..1163107 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1163031 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1163108..1163599 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1163108..1163599 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1163572..1164738 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1163572..1164738 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1164729 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1164814..1165764 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1164814..1165764 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1165781..1166692 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1165781..1166692 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1166706 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1166751..1166858 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1166831..1166836 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166852..1166870 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166860 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1166897..1167649 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1166897..1167649 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1167629 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1167684..1168676) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1167684..1168676) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1167705) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1168735..1168949) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1168735..1168949) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1168783) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1168968..1168987) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1168981) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1169236..1169243 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1169257..1169419 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1169258..1169277 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1169258 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1169420..1171057 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1169420..1171057 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1170951 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1171058..1171164 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1171165..1172100 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1171165..1172100 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1171208..1171227) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171225) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1171243..1171249) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1172104..1173021 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1172104..1173021 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1173026..1174102 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1173026..1174102 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1174104..1175021 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1174104..1175021 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1174991 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1175071..1175074 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1175087 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1175089..1175108 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1175128..1176345 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1175128..1176345 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1176398..1176407 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1176420..1176435 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1176429..1176508 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1176429 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1176509..1177087 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1176509..1177087 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1177088..1177202 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1177139..1177158) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1177143) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1177172..1177179) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1177205..1177218 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1177205 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1177268..1177663 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1177268..1177663 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1177499..1177599) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1177539) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1177661 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1177706..1178495 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1177706..1178362) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1177706..1178362) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1178392..1178410) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1178407) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1178425..1178430) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1178468..1178475 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178489..1178508 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1178497..1178638 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1178497 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1178532..1178672 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1178532..1178672 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1178639..1179295 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1178639..1179295 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1179285 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1179290..1179412) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1179290..1179412) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1179330..1179419 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1179398..1179406 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1179417..1179435 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1179421..1179485 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1179421 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1179486..1180607 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1179486..1180607 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1180261..1180267 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1180279 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1180282..1180300 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1180493..1180501 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1180513..1180531 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1180520 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1180601..1180607 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1180622..1180633 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1180631 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1180654..1182666 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1180654..1182666 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1180729..1180736 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1180751..1180770 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1180763 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1182613 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1182667..1182968 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1182704..1182871) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1182704..1182871) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1182717) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1182891..1182909) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1182907) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1182925..1182930) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1182961..1182968 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1182970..1183095 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1182970 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1182976..1183114 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1182976..1183114 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1182983..1183002 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1183052 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1183185..1184084) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1183185..1184084) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1183216) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1183420..1183425 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1183432 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1183441..1183459 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1183448..1185349 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1184081..1184479) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1184081..1184479) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1184480..1184659) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1184651..1184670) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1184659) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1184682..1184689) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1184734..1185279) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1184734..1185279) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1184758) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1185280..1185482) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1185483..1186055) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1185483..1186055) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1185628..1185646) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1185637) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1185659..1185666) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1186084..1186103) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1186101) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1186117..1186120 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1186118..1186125) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1186133 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1186136..1186155 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1186180..1186548 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1186180..1186548 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1186577..1187212 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1186577..1187212 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1187231..1188031 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1187231..1188031 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1188094..1188945 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1188094..1188945 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1188904 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188958..1189692) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1188958..1189692) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1188980) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1189814..1189818 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1189835..1189854 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1189849 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1189850..1189926 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1189927..1191771 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1189927..1191771 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1190254..1190273) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1190278) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1191773..1191780 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1191794..1191813 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1191800 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1191833..1191941 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1191833..1191941 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1191936 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1192020..1192730 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1192020..1192730 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1192705..1193322 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1192705..1193322 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1193306..1194415 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1193306..1194415 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1194415..1194615 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1194415..1194615 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1194612..1195382 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1194612..1195382 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1195379..1196389 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1195379..1196389 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1196408..1197223 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1196408..1197223 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1197197 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1197270..1197276 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1197289..1197308 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197299 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1197359..1198135 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1197359..1198135 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1198124 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" promotor_-35 1198183..1198188 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198204..1198222 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198208 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1198220..1198234) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198220) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1198236..1198919 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" /label="cotO CDS" gene 1198236..1198919 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /label="cotO gene" promotor_-35 complement(1198242..1198246) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1198914 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1199002 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1199013..1199459) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" /label="cotZ CDS" gene complement(1199013..1199459) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /label="cotZ gene" downshifts complement(1199034) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1199460..1199586) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1199587..1200075) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" /label="cotY CDS" gene complement(1199587..1200075) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /label="cotY gene" promotor_-35 1199755..1199761 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199776..1199795 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199794 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1200071..1200075 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200084..1200098 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1200102 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1200112..1200131) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200129) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200145..1200154) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1200161..1200179) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200178) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200195..1200200) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1200212 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1200227..1200745) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" /label="cotX CDS" gene complement(1200227..1200745) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /label="cotX gene" downshifts complement(1200251) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" /label="downshifts" downshifts 1200256 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature complement(1200746..1200843) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1200844..1201161) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" /label="cotW CDS" gene complement(1200844..1201161) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /label="cotW gene" CDS complement(1201202..1201588) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" /label="cotV CDS" gene complement(1201202..1201588) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /label="cotV gene" promotor_-35 1201584..1201588 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201596..1201610 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201598 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1201608..1201627) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1201630) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1201632..1202136) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 1201685..1201690 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1201706..1201724 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1201708 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="upshifts" CDS 1201748..1202104 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" /label="yjcA CDS" gene 1201748..1202104 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /label="yjcA gene" promotor_-35 1202114..1202123 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1202121..1202140) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1202129..1202362) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" /label="protein remnant CDS" gene complement(1202129..1202362) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo /label="gene" upshifts complement(1202136) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="upshifts" S_feature 1202137..1202323 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1202137..1202154 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1202137 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="upshifts" promotor_-35 complement(1202154..1202163) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1202180) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" downshifts 1202280 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" upshifts complement(1202334) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1202335..1202344 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1202342..1202349) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1202358..1202377 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202368 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" CDS 1202386..1202592 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" /label="yjzK CDS" gene 1202386..1202592 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /label="yjzK gene" CDS 1202429..1202644 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" /label="yjcB CDS" gene 1202429..1202644 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /label="yjcB gene" promotor_-35 1202616..1202625 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1202638..1202657 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202643 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1202650..1202664) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1202664) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1202674..1202678) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1202674..1202823 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" /label="yjcZ CDS" gene 1202674..1202823 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /label="yjcZ gene" downshifts 1202764 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature 1202824..1202955 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1202956..1203210 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" /label="spoVIF CDS" gene 1202956..1203210 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /label="spoVIF gene" downshifts 1203195 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" /label="downshifts" downshifts complement(1203214) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" /label="downshifts" S_feature 1203240..1204340 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1203284..1205563) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1203284..1205563) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1203302) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1205438..1205612) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1205491..1205499 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205510..1205528 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1205514..1205649 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1205514 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1205600..1205619) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1205611) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1205627..1205633 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1205635..1205639) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205648..1205666 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1205651 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1205680..1205934 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1205680..1205934 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1205910 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1206000) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1206007..1206429) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1206007..1206429) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1206433..1206948) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1206433..1206948) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1206985..1207707) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1206985..1207707) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1207746..1207765) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1207767) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1207816..1207823 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1207838..1207857 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1207842 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1207875..1207995 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1207875..1207995 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1208000 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1208063..1209184 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1208063..1209184 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1209177..1210349 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1209177..1210349 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1210332 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1210366..1210384 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1210376 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1210377..1211906 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1210382..1210927) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1210382..1210927) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1210403) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1210997..1212187) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1210997..1212187) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1212213..1212232) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212217) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212247..1212254) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1212281..1212288 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1212292 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1212302..1212321 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1212360..1212432 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1212360..1212432 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1212374..1212391) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212388) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212412..1212418) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1212422 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1212447..1213182) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1212467..1214115 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1212476) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1213184..1213272) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1213227) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1213273..1214502) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1213273..1214502) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1213395) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1214072 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1214503..1214588) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1214543..1214550 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1214565..1214584 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1214574..1214593) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1214578 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1214592) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1214606..1214612) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1214628..1214948 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1214628..1214948 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1214958 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1215003..1215100 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1215101..1215232 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1215101..1215232 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1215248..1215421 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1215248..1215421 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1215458..1215919 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1215458..1215919 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1215890..1215897 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1215912..1215931 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1215920..1216160 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1215920 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1216133..1216140 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1216154..1216172 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1216162 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1216185..1216688 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1216185..1216688 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1216700..1216984 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1216700..1216984 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1216954 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1216986) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1216997..1217000) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1217145..1217672 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1217145..1217672 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1217819..1217824 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217837..1217856 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217840 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1217846..1218163 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1217846..1218163 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1218164..1218399 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1218400..1219155 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1218400..1219155 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1219156..1219243 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1219200 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1219243..1219303) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1219274) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1219304..1219651) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1219304..1219651) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1219683..1219701) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1219696) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1219698..1220154) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1219712..1219720) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1220114..1220132 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1220126 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1220132..1220151) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1220154) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1220165..1220172) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1220202..1222148 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1220202..1222148 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1222124 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1222178..1222179 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1222179..1222277 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1222252..1222258 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1222273..1222292 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1222279..1222347 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1222279 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1222348..1222830 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1222348..1222830 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1222810 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1222876..1223382) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1222876..1223382) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1222900) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1223407..1223426) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1223413) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1223415..1223600) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1223601..1223996) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1223601..1223996) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1224019..1224037) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224032) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1224034..1224734) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1224052..1224057) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1224140..1224147 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1224161..1224180 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1224172 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1224225..1224704 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1224225..1224704 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1224703 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1224744..1224938) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1224744..1224938) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1224779) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1224952..1224967) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224968) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1224979..1224988) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1225104..1225433) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1225104..1225433) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1225470..1225489) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225483) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1225485..1226052) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1225504..1225509) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1225537..1225541 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1225557..1225576 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1225561..1226062 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1225561 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1226053..1227042) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1226053..1227042) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1227043..1227062) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1227046) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1227076..1227081) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1227165..1227413) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1227165..1227413) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1227175) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1227409..1227413 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1227422..1227436 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1227431 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1227438..1227457) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227447) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1227471..1227480) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1227528..1227535 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1227542..1227561) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1227549..1227568 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227551) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1227562 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1227563..1227666 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1227575..1227582) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1227667..1229070 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1227667..1229070 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1229059 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1229110..1229583) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1229110..1229583) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1229114) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1229605..1229623) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1229623) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1229638..1229643) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1229708..1229875) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1229708..1229875) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1229711) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1229887..1229905) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1229896) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1229918..1229925) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1230002..1230901 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1230002..1230901 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1230910..1231308) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1230910..1231308) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1230940) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1231337..1231356) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1231356) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1231371..1231378) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1231409..1231984) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1231409..1231984) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1231424) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1232003..1232021) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232018) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1232035..1232041) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1232059..1232065 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1232080..1232098 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232081 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1232130..1235087 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1232130..1235087 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1235080..1235640 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1235080..1235640 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1235633 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1235678..1235796 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1235774..1235777 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235793..1235812 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235798 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1235837..1236478 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1235837..1236478 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1235846) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1236451 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1236557..1237183 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1236557..1237183 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1237185 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1237188) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1237214..1237492) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1237214..1237492) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1237232) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1237521..1237532) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1237534..1237540) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1237540) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1237542..1237958) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1237710 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1237711..1237730 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1237728..1237882 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1237883..1239073 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1237883..1239073 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1237956..1237975) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1237958) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1237989..1237998) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1239096..1240274 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1239096..1240274 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1240315..1240503) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1240315..1240503) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1240331) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1240529..1240548) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240532) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240562..1240568) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1240590..1240597 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240612..1240631 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240623 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1240638..1240657) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240642) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240672..1240679) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1240677..1241489 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1240677..1241489 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1241468 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1241535..1242287) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1241535..1242287) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1241544) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1242287..1243039) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1242287..1243039) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1243159..1244133) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1243159..1244133) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1243194) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1244154..1244173) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244180) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1244182..1246688) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1244188..1244195) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1244216..1244222 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244237..1244255 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1244240 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1244265..1244762 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1244265..1244762 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1244763..1244876 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1244856..1244860 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244876..1244895 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1244878..1245150 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1244878 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1245151..1245573 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1245151..1245573 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1245613..1246791 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1245613..1246791 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1246622..1246722 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1246680..1246698) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246682 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1246688) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1246710..1246718) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1246790 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1246899..1246906 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1246921..1246940 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246946 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1246989..1248410 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1246989..1248410 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1248478..1249857 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1248478..1249857 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1248997..1249016) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1249002) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1249030..1249037) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1249882 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1249892..1249899 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1249894..1249961 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1249962..1250975 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1249962..1250975 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1250981..1252000 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1250981..1252000 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1252025..1253104 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1252025..1253104 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1253101..1253937 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1253101..1253937 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1253985..1255253 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1253985..1255253 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1255197..1255200 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255216..1255220 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1255218 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1255286..1255305 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1255286 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1255341..1256342 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1255341..1256342 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1256024..1256124) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1256064) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1256318 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1256419..1257861 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1256419..1257861 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1257858..1259351 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1257858..1259351 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1259390..1260154) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1259390..1260154) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1259409) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1259922,1259924) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1260181,1260188) /created_by="User" /modified_by="User" /label="TF8A" N_region 1260182..1260187 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1260190..1260510 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1260190..1260510 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1260519 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1260528..1260731) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1260547..1260684) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1260547..1260684) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1260571) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1260770..1260940) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1260770..1260940) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1260776) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1260940..1261686) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1260940..1261686) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1261521..1261540) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261538) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1261556..1261563) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1261712..1261730) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261725) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1261746..1261751) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1261796..1262797) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1261796..1262797) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1261825) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1262810..1263427) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1262810..1263427) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1263463..1263482) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263465) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1263467..1263564) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1263498..1263502) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1263544..1263563) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263564) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263578..1263585) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1263609..1263628) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1263621) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1263703..1265019) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1263703..1265019) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1263718) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1265066..1265085) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1265082) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1265100..1265103) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1265302..1265309 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1265324..1265343 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1265336..1265407 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1265336 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1265408..1266358 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1265408..1266358 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1266346 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1266459..1266605 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1266459..1266605 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1266613..1268763 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1266613..1268763 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1267502..1267602 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1267562 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1267650 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1268775..1269746 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1268775..1269746 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1269103..1269744) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1269789) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1269814..1270180) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1269857) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1270160..1270175) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270180) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1270187..1270196) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1270264..1271613) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1270264..1271613) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1270278) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1271653..1271660 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1271665..1271684) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271673 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1271675..1271694 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1271683) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1271685..1271767) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1271695..1271702) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1271724..1271730 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1271745..1271764 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271748 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1271750..1271769) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1271767) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1271782..1272600 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1271782..1272600 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1271785..1271788) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1272578 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1272657..1272664 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272679..1272698 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1272683 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1272729..1273553 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1272729..1273553 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1273570..1274496 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1273570..1274496 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1274502..1275464 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1274502..1275464 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1275196..1275201 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1275217..1275235 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1275218 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1275469..1276476 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1275469..1276476 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1276479..1278128 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1276479..1278128 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1278122 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1278216..1279175 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1278216..1279175 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1279172..1280272 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1279172..1280272 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1280269..1281159 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1280269..1281159 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1281172..1282161 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1281172..1282161 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1281455..1282182) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1282151 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1282196..1283364 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1282204..1283253) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1282204..1283253) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1282227) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1283280..1283299) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283291) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1283314..1283321) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1283343..1284203) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1283343..1284203) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1284228..1284246) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1284245) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1284262..1284268) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1284277..1284284 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1284298..1284317 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1284305 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1284363..1284881 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1284363..1284881 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1284872 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1284946..1284952 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1284964..1285070 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1284964 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1284966..1284977 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1285045..1285048 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285064..1285083 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285072 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1285120..1286319 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1285120..1286319 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1286308 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1286353..1286724 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1286396..1286620) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1286396..1286620) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1286700..1286706 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1286720..1286731 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1286726 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1286765..1287496 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1286765..1287496 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1287474 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1287535..1287543 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1287554..1287572 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1287562 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1287588..1288115 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1287588..1288115 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1288105..1288623 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1288105..1288623 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1288617..1288624 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1288638..1288657 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1288641 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1288656..1288767 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1288656..1288767 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1288730 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1288845..1289183 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1288845..1289183 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1289183..1289500 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1289183..1289500 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1289500..1289503 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289519..1289538 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289531 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1289571..1290473 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1289571..1290473 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1290464 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1290520..1290526 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1290532 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1290540..1290559 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1290561..1290771 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1290561..1290771 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1290729 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1290824..1291921 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1290824..1291921 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1291011..1291013 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291015..1291019 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291015 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1291933..1293180 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1291933..1293180 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1293171 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1293242..1293249 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1293264..1293283 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1293273 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1293306..1293731 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1293306..1293731 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1293720 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1293762..1294205) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1293762..1294205) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1293796) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1294232..1294251) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294238) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1294266..1294269) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1294287..1294293 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1294307..1294325 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1294313 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1294348..1294758 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1294348..1294758 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1294736 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1294785..1294955 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1294785..1294955 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1294956..1295633 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1295005..1295475) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1295005..1295475) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1295029) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1295497..1295516) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1295513) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1295515..1295622) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1295532..1295535) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1295591 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1295648..1297936) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1295648..1297936) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1295667) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1297937..1297999) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1297959..1298059) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1297999) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1298064..1298219) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1298064..1298219) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1298065) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1298252..1298271) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298264) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1298266..1298351) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1298287..1298294) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1298352..1299311) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1298352..1299311) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1299312..1299363) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1299356..1299375) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1299368) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1299389..1299395) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1299480..1299483 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1299496 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1299499..1299518 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1299534..1300367 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1299534..1300367 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1300343 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1300398..1301162) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1300398..1301162) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1300419) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1301137..1302780) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1301137..1302780) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1302767..1303366) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1302767..1303366) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1303368..1303970) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1303368..1303970) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1304048) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1304067..1304179) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1304067..1304179) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1304180..1304183 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1304194..1304213) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1304199..1304218 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1304210 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1304215) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1304228..1304235) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1304281..1304967 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1304281..1304967 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1304971..1306335 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1304971..1306335 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1306332..1307012 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1306332..1307012 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1307041..1307046 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307062..1307080 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307065 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1307104..1307616 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1307104..1307616 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1307602 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1307647..1307653 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307667..1307678 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307668 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1307699..1307836 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1307699..1307836 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1307809 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1307895..1307902 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307916..1307935 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1307918..1308237 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1307918 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1307950..1308103 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1307950..1308103 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1308215..1308224 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308237..1308256 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1308239..1308340 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1308239 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1308341..1309696 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1308341..1309696 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1309687 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1309739..1310071) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1309739..1310071) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1310087..1310106) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1310097) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1310099..1310487) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1310122..1310127) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1310159..1310259 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1310219 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1310266..1310421 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1310266..1310421 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1310430..1310437 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310444..1310461 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1310461 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1310472..1310491) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1310487) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1310505..1310511) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1310509..1310691 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1310509..1310691 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1310659 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1310716..1310724 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310735..1310753 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1310741..1310823 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1310741 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1310824..1311288 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1310824..1311288 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1311273 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1311303..1312424) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1311303..1312424) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1311712..1311720 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311734..1311753 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1311737..1312515 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1311737 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1312453..1312464) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1312473) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1312479..1312485) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1312516..1313067 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1312516..1313067 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1313035 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1313095..1313907) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1313095..1313907) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1313867..1313886) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313881) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1313900..1313905) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1314008..1314014 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1314025..1314099 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1314025 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1314028..1314039 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1314100..1315794 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1314100..1315794 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1315807..1316820 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1315807..1316820 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1316805 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1316846..1318681) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1316846..1318681) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1316895) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1318685..1319620) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1318685..1319620) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1319591..1319602) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319601) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1319617..1319623) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1319657..1322059) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1319657..1322059) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1319689) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1321907..1322109) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1322098..1322116) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322109) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1322130..1322137) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1322176..1322183 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322197..1322216 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322209 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1322240..1322905 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1322240..1322905 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1322774..1322793) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322791) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1322807..1322816) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1322900..1322907 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322922..1322941 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322935 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1322961..1323094 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1322961..1323094 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1322982..1323956 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1322982..1323956 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1323045 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1323944 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1324066..1324074 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1324088..1324096 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1324098 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1324101..1324187 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1324160..1324167 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1324181..1324200 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1324189 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1324220..1324975 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1324220..1324975 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1324972..1326117 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1324972..1326117 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1326118..1327277 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1326128..1326322) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1326128..1326322) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1326135) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1326365..1326376) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1326375) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1326391..1326397) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1326453..1327154) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1326453..1327154) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1326487) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1327155..1327235) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1327227..1327246) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1327235) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1327251..1327258 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1327260..1327267) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1327272..1327291 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1327279 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1327325..1328221 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1327325..1328221 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1328215 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1328326..1328330 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1328346..1328365 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328350 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1328395..1329744 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1328395..1329744 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1329732 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1329793..1329799 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329813..1329824 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1329821..1329888 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1329821 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1329889..1330044 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1329889..1330044 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1330047..1330223 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1330047..1330223 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1330113..1330213 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1330173 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1330219 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1330266..1331288) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1330266..1331288) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1330289) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1331333..1331352) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1331349) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1331364..1331370) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1331477..1331485 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1331493 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1331496..1331514 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1331541..1333757 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1331541..1333757 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1333532..1334472) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1333610..1333617 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1333632..1333651 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1333634 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1333754..1334251 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1333754..1334251 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1334252..1334491 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1334341..1334466 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1334341..1334466 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1334459 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1334500..1335561) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1334500..1335561) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1334517) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1335569..1336762) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1335569..1336762) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1335629 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1336849) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1336855..1337011) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1336855..1337011) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1337046..1337065) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337047) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1337081..1337088) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1337091..1337094 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1337095..1337874) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1337095..1337874) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1337110..1337129 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1337119 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1337567..1337574 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1337587..1337606 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1337602 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1337609..1337926 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1337896..1337903 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1337904..1337923) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1337918..1337937 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337918) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1337928 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1337939..1337946) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1337969..1339165 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1337969..1339165 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1339147..1339154 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1339169..1339188 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1339188 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1339204..1339304 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1339204..1339304 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1339303 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1339389..1340606 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1339389..1340606 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1340603..1341310 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1340603..1341310 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1341268..1341897 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1341268..1341897 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1341912..1342448 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1341912..1342448 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1342295..1342488) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1342448 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1342489..1342809) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1342489..1342809) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1342547) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1342810..1342899) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1342835..1342841 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342856..1342874 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342866 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1342867..1342951 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1342881..1342900) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1342898) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1342915..1342918) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1342925..1342932 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342947..1342966 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1342953..1343011 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1342953 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1343009) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1343012..1343269 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1343012..1343269 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1343263 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1343355..1343786 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1343355..1343786 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1343814..1345334) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1343814..1345334) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1343826) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1344535..1344541 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1344555..1344566 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1344561 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1345342..1345361) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1345363) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1345461..1345468 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345483..1345502 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345485 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1345527..1345964 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1345527..1345964 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1345947 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1346004..1346789) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1346004..1346789) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1346023) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1346485) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1346761..1347573) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1346761..1347573) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1347604..1347622) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1347620) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1347636..1347643) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1347711..1347933) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1347743) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1347956..1350055) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1347956..1350055) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1347978) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1350056..1350306) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1350266..1350366) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1350306) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1350342..1350347 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1350357 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1350363..1350381 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1350420..1351463 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1350420..1351463 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1351464..1351555 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1351532..1351536 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1351553..1351572 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1351557 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1351602..1351646 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1351602..1351646 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1351623 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1351668..1351775 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1351776..1352435 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1351776..1352435 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1352428..1352877 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1352428..1352877 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1352870..1353601 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1352870..1353601 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1353619..1354116 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1353619..1354116 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1354117..1354393 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1354351 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1354361) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1354430..1354674) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1354471) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1354675..1355031) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1354675..1355031) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1355062..1355081) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1355079) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1355116..1355134 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1355121 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1355200..1355946 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1355200..1355946 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1356001 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1356349..1356357 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1356371..1356390 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1356375 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1356427..1357626 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1356427..1357626 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1356509..1356515 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1356530..1356548 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1356536 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1357595..1357597 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1357617..1357635 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1357629 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1357642..1357869 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1357642..1357869 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1357719..1357738) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1357727) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1357870..1357965 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1357966..1358664 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1357966..1358664 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1358617..1359443) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1358645..1358896 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1358645..1358896 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1359146..1359161 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1359169..1359380 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1359169 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1359345 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1359432..1359451) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1359454) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1359467..1359474) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1359519..1359526 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359541..1359560 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359543 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1359579..1359869 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1359579..1359869 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1359906..1359989) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1359949) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1359990..1360175) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1359990..1360175) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1360208..1360227) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360219) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1360221..1360565) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1360241..1360248) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1360274..1360279 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1360295..1360314 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1360302 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1360341..1360535 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1360341..1360535 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1360511 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1360556..1360574) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360572) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1360591..1360596) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1360834..1361460 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1360834..1361460 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1361391 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1361517..1361522 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1361529 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1361538..1361556 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1361578..1362915 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1361578..1362915 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1362966..1363463 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1362966..1363463 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1363312..1363318 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1363327 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1363333..1363351 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1363437 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1363558..1363564 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363575..1363594 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363587 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1363591..1363698 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1363699..1365612 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1363699..1365612 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1363848..1363867) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1363865) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1363880..1363889) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1364016..1364035) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364041) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1364049..1364055) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1365593 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1365669) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1365880..1365899) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1365889) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1365913..1365920) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1365964..1365983 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1365974 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1366019..1367110 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1366019..1367110 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1366759 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1367089 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1367123..1367341) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1367134..1367391 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1367328..1367347) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1367341) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1367363..1367370) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1367392..1368357 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1367392..1368357 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1368375..1368382 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1368397..1368416 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1368409 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1368420..1369286 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1368420..1369286 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1369141..1369145 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369162..1369181 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369170 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1369288 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1369333..1369484 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1369333..1369484 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1369333..1369484 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1369462..1369468 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369482..1369493 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369486 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1369515..1371614 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1369515..1371614 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1371632..1371636 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1371652..1371671 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1371663 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1371712..1371978 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1371712..1371978 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1371978..1373690 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1371978..1373690 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1373677 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1373730..1373736 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1373751..1373762 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1373754 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1373781..1374020 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1373781..1374020 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1373801..1375140) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1374098..1375126 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1374098..1375126 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1375096 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1375141..1375821) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1375141..1375821) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1375831..1375850) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1375854) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1375865..1375872) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1375906..1375913 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1375927..1375945 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1375933 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1375956..1377923 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1375956..1377923 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1376396..1376411) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1376408) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1377894 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1377967..1377969 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1377985..1378004 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1377995 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1378037) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1378061..1378927 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1378061..1378927 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1378907 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1378966..1379739) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1378966..1379739) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1378983) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1379771..1379790) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1379781) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1380014..1380033 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1380027 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1380029..1380132 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1380076..1382190 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1380076..1382190 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1381369..1381387) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1381381) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1381403..1381408) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1382171 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1382263..1382271 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1382283..1382301 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1382295 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1382354..1384174 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1382354..1384174 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1384185..1385366) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1384185..1385366) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1384219) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1385394..1385413) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1385410) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1385442..1385460) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385454) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1385456..1385524) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1385475..1385480) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1385518..1385537) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1385524) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1385568..1385729) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1385568..1385729) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1385752..1385771) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385765) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1385785..1385792) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1385866..1385873 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1385885 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1385886..1385904 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1385933..1386844 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1385933..1386844 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1385938) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1386387..1386395 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1386409..1386426 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1386412 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1386829 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1386888..1387352) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1386888..1387352) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1386906) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1387382..1387401) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387392) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1387416..1387423) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1387478..1388770) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1387478..1388770) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1387500) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1388794..1388813) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1388798) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1388829..1388833) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1388846..1389340) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1388846..1389340) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1389356..1389375) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389372) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1389389..1389398) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1389397..1390257) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1389397..1390257) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1390278..1390297) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1390291) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1390328..1390335 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1390351..1390370 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1390364 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1390400..1391164 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1390400..1391164 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1391165..1391313 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1391294..1391312 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1391315..1391464 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1391315 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1391362) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1391465..1393195 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1391465..1393195 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1393261..1393779 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1393261..1393779 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1393777 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1393822..1393827 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393840..1393859 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393843 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1393875..1394423 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1393875..1394423 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1394424..1394575 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1394576..1395799 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1394576..1395799 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1395762..1395780) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395772) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1395778 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1395795..1395800) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1395848..1395855 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1395867..1395968 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1395867 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1395870..1395889 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1395885..1395968 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1395885..1395968 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1395925 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1395979..1395984 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1395999..1396283 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1395999 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1396001..1396019 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1396260..1396266 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1396280..1396291 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1396285..1396372 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1396285 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1396361..1396380 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1396374 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1396445..1396684 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1396445..1396684 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1396685..1396793 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1396794..1397312 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1396794..1397312 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1397349..1397356 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1397370..1397389 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1397384 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1397446..1397643 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1397446..1397643 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1397639 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1397684..1397780 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1397781..1398224 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1397781..1398224 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1398225..1398332 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1398300..1398305 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398320..1398339 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398334 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1398373..1399254 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1398373..1399254 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1399233 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1399289..1399296 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1399311..1399330 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1399316 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1399366..1399842 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1399366..1399842 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1399832..1400725 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1399832..1400725 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1400741..1401196 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1400741..1401196 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1401012..1401031) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401025) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1401045..1401053) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1401190 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1401235..1401242 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1401256..1401275 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1401257 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1401301..1402011 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1401301..1402011 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1401310) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1401420..1401424) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401420) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1402081..1403205 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1402081..1403205 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1403217..1403223 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1403237..1403248 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1403239 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1403243..1403257) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1403267..1403271) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1403267..1403512 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1403267..1403512 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1403268) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1403500 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1403545..1404495 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1403549..1404352) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1403549..1404352) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1403561) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1404403..1404422) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1404412) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1404436..1404443) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1404468..1404475 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1404490..1404509 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1404497..1404588 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1404497 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1404589..1405131 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1404589..1405131 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1405203..1405649 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1405203..1405649 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1405657 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1406042..1406049 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1406062 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1406064..1406083 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1406115..1406690 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1406115..1406690 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1406668 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1406731..1407696) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1406731..1407696) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1406744) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1407040..1407041 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1407059..1407078 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1407065..1407789 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1407065 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1407717..1407735) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407738) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1407750..1407755) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1407776..1407782 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1407792 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1407796..1407815 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1407833..1408432 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1407833..1408432 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1408483..1409502 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1408483..1409502 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1409520..1410812 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1409520..1410812 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1410773..1411294 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1410773..1411294 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1411294..1411767 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1411294..1411767 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1411760..1411993 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1411760..1411993 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1411972 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1412038..1412043 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1412060..1412078 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1412068 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1412080..1412166 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1412156..1412159 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1412168 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1412174..1412193 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1412217..1413974 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1412217..1413974 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1413986..1415800 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1413986..1415800 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1414423..1414442) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1414433) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1414457..1414464) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1415851..1415860 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1415872..1415887 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1415876 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1415910..1416605 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1415910..1416605 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1416610..1417743 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1416610..1417743 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1417744..1418436 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1417744..1418436 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1418433..1419626 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1418433..1419626 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1419604 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1419675..1419681 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1419695..1419706 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1419703 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1419748..1419755 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1419770..1419789 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1419775..1419866 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1419775 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1419830..1419837 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1419851..1419870 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1419868 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1419906..1420661 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1419906..1420661 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1420054) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1420056..1420058) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1420658..1421569 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1420658..1421569 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1421584..1423491 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1421584..1423491 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1423476 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1423560..1423567 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1423578..1423597 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1423581 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1423636..1424217 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1423636..1424217 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1424202 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1424246 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1424251..1424520) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1424251..1424520) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1424256) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1424521..1424586) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1424567..1424586) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1424586) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1424639..1424646 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1424657..1424676 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1424661 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1424701..1426323 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1424701..1426323 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1426311 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1426380..1427291 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1426380..1427291 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1427296 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1427325..1428557) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1427325..1428557) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1427336) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1428575..1428594) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428599) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1428609..1428614) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1428667..1428801) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1428667..1428801) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1428678) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1428823..1428841) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428834) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1428836..1428901) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1428857..1428862) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1428902..1429909) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1428902..1429909) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1429955) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1429956..1429964) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1429978..1429986) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1430096..1430105 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1430117 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1430118..1430133 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1430120..1430192 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1430193..1430471 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1430193..1430471 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1430469 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1430503..1432132) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1430514..1430618 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1430526) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1430600..1430607 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430619..1430638 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1430620 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1430661..1431947 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1430661..1431947 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1431963..1432796 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1431963..1432796 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1432129..1432147) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1432144) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1432163..1432168) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1432859..1433524 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1432859..1433524 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1433508 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1433615..1433621 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1433636..1433655) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1433636..1433655 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433648 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1433650) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1433679..1435412 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1433679..1435412 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1434807..1435411) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1435401 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1435446..1437113) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1435446..1437113) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1435456) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1437119..1437328) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1437119..1437328) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1437365..1437384) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1437387) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1437389..1437566) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1437399..1437402) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1437567) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1437569..1437580) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1437594..1437600) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1437639..1437646 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1437660..1437679 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1437676 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1437714..1438487 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1437714..1438487 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1438458 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1438523..1439077) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1438523..1439077) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1438534) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1439099..1439118) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439109) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1439133..1439140) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1439162 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1439186) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1439187..1439345) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1439187..1439345) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1439252..1439395) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1439252..1439395) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1439341..1439345 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1439346..1439414) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1439355..1439369 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439382 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1439398..1439417) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439427) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1439430..1439439) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1439501..1439508 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439522..1439541 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439526 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1439559..1440230 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1439559..1440230 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1439898..1439907 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439920..1439938 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439932 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1440177 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1440405..1440410 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440427..1440446 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1440428..1440653 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1440428 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1440432..1440451) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1440448) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1440552..1440560) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1440558) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1440574..1440582) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1440654..1441769 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1440654..1441769 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1441773..1442750 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1441773..1442750 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1442751..1442864 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1442785..1442804) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1442802) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1442819..1442822) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1442865..1444193 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1442865..1444193 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1443009..1443016 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1443031..1443050 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1443034 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1444198..1445610 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1444198..1445610 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1445607 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1445655..1446029) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1445655..1446029) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1445703) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1446060..1446079) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1446070) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1446233..1446238 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1446254..1446272 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1446264 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1446268..1446377 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1446300) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1446361..1446368 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1446379 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1446383..1446402 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1446398..1446608 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1446398..1446608 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1446448..1446567 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1446448..1446567 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1446454) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1446554 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1446599..1448202 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1446607..1448079) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1446607..1448079) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1446625) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1448080..1448175) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1448158..1448177) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1448175) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1448182..1448185 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1448192..1448199) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1448200..1448219 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1448204 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1448264..1448530 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1448264..1448530 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1448512 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1448563..1449201) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1448563..1449201) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1448588) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1449222..1449241) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1449246) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1449256..1449260) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1449271..1449277 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449292..1449310 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449293 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1449331..1449340 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449353..1449372 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1449357..1449440 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1449357 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1449441..1449629 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1449441..1449629 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1449446) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1449622 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1449644) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1449652..1449655) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1449699..1449702 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449719..1449738 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449722 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1449769..1450566 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1449769..1450566 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1450592..1451020 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1450592..1451020 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1450977 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1451021..1451974 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1451096) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1451098..1452012) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1451098..1452012) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1452078..1452097) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1452086) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1452112..1452119) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1452364..1453929) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1452364..1453929) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1453964..1453983) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1453975) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1453997..1454004) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1454214..1456154 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1454214..1456154 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1456144..1456413 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1456144..1456413 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1456379..1456383 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1456397..1456416 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1456410 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1456413..1456934 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1456413..1456934 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1456931..1457224 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1456931..1457224 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1457264..1457875) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1457264..1457875) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1457278) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1457907..1457926) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1457916) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1457941..1457944) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1458131) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1458148..1458336) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1458148..1458336) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1458202) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1458358..1458377) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1458375) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1458390..1458397) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1458403..1458422 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1458410 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1458449..1460287 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1458449..1460287 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1460344..1460661 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1460344..1460661 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1460635 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1460710) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1460717..1460926) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1460717..1460926) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1460940..1460959) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1460955) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1461009..1461638) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1461009..1461638) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1461040) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1461540..1461558) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461546) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1461570..1461578) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1461673..1461684) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461678) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1461690..1461695 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1461699..1461705) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1461711..1461729 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1461711 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1461712..1461792 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1461793..1463121 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1461793..1463121 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1462977..1463124) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1463020) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1463122..1463712 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1463125..1463610) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1463125..1463610) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1463622..1463641) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1463650) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1463656..1463663) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1463713..1464642 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1463713..1464642 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1464227..1464246 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1464236 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1464666..1464669 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1464684..1464703 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1464692 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1464740..1465021 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1464740..1465021 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1465010 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1465084..1465087 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1465100..1465226 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1465100 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1465105..1465111 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1465227..1466438 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1465227..1466438 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1466448..1466452 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1466467..1466486 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1466486 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1466513..1469959 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1466513..1469959 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1469525..1469543) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1469545) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1469559..1469564) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1469939 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1469984 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1470016) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1470028 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1470362..1471282) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1470362..1471282) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1470368) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1471322..1471341) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1471337) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1471355..1471362) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1471417..1471424 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1471438..1471457 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1471439..1471544 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1471439 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1471546..1471636 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1471546 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1471552..1471555 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1471570..1471586 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1471637..1472554 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1471637..1472554 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1472583 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1472602 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1472603..1472608 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1472662..1472667 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1472682..1472700 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1472690..1472793 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1472690 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1472794..1473864 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1472794..1473864 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1473897..1475765 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1473897..1475765 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1475765..1476388 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1475765..1476388 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1476391..1476723 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1476391..1476723 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1476750..1477643 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1476750..1477643 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1477618 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1477675..1478037) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1477675..1478037) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1477694) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1478030..1478034 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478043..1478056 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1478061..1478080) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1478065..1478176 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1478065 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1478073) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1478095..1478102) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1478177..1478623 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1478177..1478623 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1478209..1478216 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478228..1478247 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478233 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1478632..1478639 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478653..1478672 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478664 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1478707..1479747 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1478707..1479747 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1479670..1479688) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1479675) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1479704..1479709) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1479727 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1479911..1479920 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1479934..1479953 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1479948 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1479979..1480377 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1479979..1480377 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1479983) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1480393..1480632 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1480393..1480632 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1480611 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1480699..1480706 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1480717..1480736 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1480722 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1480748..1481197 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1480748..1481197 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1481183 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1481252..1481524 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1481252..1481524 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1481329..1481552) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1481527..1481647 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1481527..1481647 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1481554..1481677) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1481597) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1481648..1481753 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1481678..1481690) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1481685) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1481705..1481711) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1481734..1481738 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1481754..1481773 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1481755..1481846 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1481755 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1481847..1482401 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1481847..1482401 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1482406..1482891 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1482406..1482891 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1482858 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1482902..1484128) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1482902..1484128) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1482903..1484177 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1484129..1484230) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1484152..1484159 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484171..1484190 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1484179..1484308 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1484179 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1484225..1484243) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1484240) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1484260..1484265) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1484309..1485091 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1484309..1485091 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1484871..1484877 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484891..1484902 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1484902 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1485093..1486118 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1485093..1486118 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1486002 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1486135..1487382) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1486135..1487382) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1486162) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1487299..1487305 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1487319..1487330 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1487323 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1487379..1487564) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1487379..1487564) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1487397..1487401 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1487417..1487436 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1487426..1487561 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1487426 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1487455..1487474) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1487465) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1487488..1487495) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1487532..1487539 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487553..1487572 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487563 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1487592..1488110 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1487592..1488110 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1488132..1488311 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1488132..1488311 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1488291 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1488334) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1488338..1488341) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1488392..1488397 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1488413..1488431 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1488414 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1488457..1489038 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1488457..1489038 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1489039 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1489095..1489577) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1489095..1489577) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1489114) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1489567 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1489600..1489619) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1489619) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1489633..1489640) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1489677..1489683 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1489695..1489714 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1489697 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1489737..1490633 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1489737..1490633 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1490704..1492323 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1490704..1492323 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1492295 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1492357..1492360 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1492375..1492448 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1492375..1492394 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1492375 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1492432) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1492449..1492880 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1492449..1492880 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1492950..1493885 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1492950..1493885 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1493552..1495004) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1493925..1494278 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1493925..1494278 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1494275..1496425 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1494275..1496425 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1494985..1495003) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1495004) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1495018..1495024) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1496408 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1496480..1496485 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1496501..1496519 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1496501 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1496542..1498482 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1496542..1498482 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1498278..1498284 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1498299..1498307 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1498305 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1498455 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1498500..1498567 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1498537..1498541 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1498557..1498576 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1498569..1498657 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1498569 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1498658..1500142 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1498658..1500142 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1500143..1500253 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1500254..1501228 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1500254..1501228 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1501229..1502584 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1501229..1502584 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1502408..1502413 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1502429..1502447 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1502439 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1502645..1503745 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1502645..1503745 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1503746..1503867 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1503868..1504959 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1503868..1504959 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1504348..1504357 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1504370..1504385 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1504375 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1504381..1504481 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1504441 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1504991..1505902 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1504991..1505902 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1505920 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1506032..1506823 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1506032..1506823 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1506820..1507515 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1506820..1507515 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1507538..1508245 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1507538..1508245 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1508263..1508628 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1508263..1508628 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1508480..1508483 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1508499..1508518 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1508515 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1508629..1508801 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1508802..1510124 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1508802..1510124 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1509009) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1509013..1509017) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1509032..1509036) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1510160..1511308 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1510160..1511308 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1511282 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 1511507..1511610 /Source="Nicolas_S_feature" /locus_tag="new_1599179_1599282" /HighExp="T5.0H, BC, T4.0H, T3.30H, T3.0H, S2, BT, M9-stat, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.953" /TUlongSig="SigA, SigWXY, SigA, Sig-" /TUlongPSig="0.989, 1, 1, 0.436" /label="S561" upshifts 1511507 /Source="Nicolas_upshifts" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1511509..1511528 /Source="Nicolas_upshift_promotors" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1511611..1515912 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillopeptidase F" /protein_id="NP_389413.1" /db_xref="EnsemblGenomes-Gn:BSU15300" /db_xref="EnsemblGenomes-Tr:CAB13403" /db_xref="GOA:P16397" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR008757" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR012103" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR033857" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10233" /db_xref="UniProtKB/Swiss-Prot:P16397" /translation="MRKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQ SAESIQNKISSSLKKSFKKKEKTTFLIKFKDLANPEKAAKAAVKKAKSKKLSAAKTEY QKRSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKV VQFPEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDG TGTVVASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGT HVTGTMVGSEPDGTNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGNP HPEMAPDVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANP ANYPESFATGATDINKKLADFSLQGPSPYDEIKPEISAPGVNIRSSVPGQTYEDGWDG TSMAGPHVSAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNA FDAVSAVTDGLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTS VKLSYKLDQGEWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSD VYDVTVKPSITAGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLT GNYANSANMNLVMPPIKAPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGV YNGKTSSWTDEEIDLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKK NKLGVEKPSGKQKKKPVNPKKAKPSANTAVKHQNKAIQPQVLPLKAQVSVVETGKSTY SDQSTGQYTLKHKAGDYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGT VINKTTGEPVTGASVYVVEDAAVEPAMTNDKGEYMLEAYEGAYTIKVAAPGYYSDEFS VELKGDVTKETALKPFVGYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGML TGGLFRFWDTEFPDPGGTEFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLS SKGIMVDKDFYLVYIQSKPDPYSPGLAMDETGQNSGRNWQYIDGKWQPGDKADGNYMI RALVDYEAAVPEITSPTDKSYTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGT FHAGIILNKGENELTATASTDNGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETL TVKGAVSDDNLKDVKVNGKKATVADGSYSARILLENGRNEIKVIATDLAGNKTTKKTV IDVNFDKPVISGLIPGEDKNLKAGESVKIAFSSAEDLDATFTIRMPLTNARASVQNAT ELPLREISPGRYEGYWTATSSIKAKGAKVEVIVRDDYGNETRKTANGKLNMNTEN*" /label="bpr CDS" gene 1511611..1515912 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /label="bpr gene" downshifts 1515909 /Source="Nicolas_upshifts" /id="D865" /incds=0 /nref=73 /ntot=169 /MaxReadThrough="0.90839" /MaxDrop="8.78054" /score="38.0577497" /energy="-11.4" /TU="NA" /idTUdmin="U1273" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(1515920..1517062) /Source="Nicolas_S_feature" /locus_tag="new_1603592_1604734_c" /HighExp="S8, S6, S7, S5, LoTm, S4, B36, T5.0H, BT, B60" /AntisenseName="spoIIGA" /AntisenseCor="0.71080549463714104" /AntisenseRegPval="-42" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.579" /TUlongSig="NA" /TUlongPSig="NA" /label="S562" downshifts complement(1515962) /Source="Nicolas_upshifts" /id="D866" /incds=0 /nref=5 /ntot=22 /MaxReadThrough="2.36451" /MaxDrop="3.61596" /score="22.1321546" /energy="-9.6" /TU="NA" /idTUdmin="U1275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1516040..1516106 /Source="Nicolas_S_feature" /locus_tag="new_1603712_1603778" /HighExp="M9-stat, T5.0H, S4, LoTm, T3.30H, T3.0H, B60, S3, S5, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S563" upshifts 1516042 /Source="Nicolas_upshifts" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="upshifts" misc_feature 1516043..1516062 /Source="Nicolas_upshift_promotors" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature complement(1516060..1516072) /Source="Nicolas_upshift_promotors" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1516072) /Source="Nicolas_upshifts" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1516107..1517036 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease processing pro-sigma-E" /protein_id="NP_389414.1" /db_xref="EnsemblGenomes-Gn:BSU15310" /db_xref="EnsemblGenomes-Tr:CAB13405" /db_xref="GOA:P13801" /db_xref="InterPro:IPR005081" /db_xref="SubtiList:BG10234" /db_xref="UniProtKB/Swiss-Prot:P13801" /translation="MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGS SIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGI IGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQ YEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIR NTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKC LIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS*" /label="spoIIGA CDS" gene 1516107..1517036 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /label="spoIIGA gene" promotor_-10 complement(1517051..1517070) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1517064) /Source="Nicolas_upshifts" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1517085..1517088) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1517099..1517818 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1581961, 7708009, 8464402, 15187183, 20802044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1581961, 7708009, 8464402, 15187183, 20802044; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-29 factor (sigma-E)" /protein_id="NP_389415.2" /db_xref="EnsemblGenomes-Gn:BSU15320" /db_xref="EnsemblGenomes-Tr:CAB13406" /db_xref="GOA:P06222" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014200" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG10235" /db_xref="UniProtKB/Swiss-Prot:P06222" /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEE QVLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTF NPEKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTD DDIITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQS YISRLEKRIIKRLRKEFNKMV*" /label="sigE CDS" gene 1517099..1517818 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /label="sigE gene" S_feature 1517819..1517908 /Source="Nicolas_S_feature" /locus_tag="new_1605491_1605580" /HighExp="T5.0H, S3, M9-stat, T4.0H, S4, LoTm, S2, B60, B36, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S564" promotor_-35 1517892..1517898 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1517910 /Source="Nicolas_upshifts" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1517912..1517923 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1517958..1518740 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15187183, 15256570, 16166546, 16497325, 17015665, 21935351" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187183, 15256570, 16166546, 16497325, 17015665, 21935351; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-G)" /protein_id="NP_389416.1" /db_xref="EnsemblGenomes-Gn:BSU15330" /db_xref="EnsemblGenomes-Tr:CAB13407" /db_xref="GOA:P19940" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014212" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10236" /db_xref="UniProtKB/Swiss-Prot:P19940" /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLV NGNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGE IRRYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFA LDAIQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMI LRKRFFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ*" /label="sigG CDS" gene 1517958..1518740 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /label="sigG gene" S_feature 1518741..1518829 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1518794..1518801 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1518814..1518833 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1518831 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1518888..1519682 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1518888..1519682 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1519600..1519603 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1519618..1519637 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1519626 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1519695..1519796 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1519695..1519796 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1519783 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1519884..1521164 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1519884..1521164 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1521105..1521121) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1521110) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1521185..1521190 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1521206..1521224 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1521210 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1521247..1521492 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1521247..1521492 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1521408..1521416 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1521427..1521445 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1521435 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1521493..1521603 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1521595..1521614 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1521605 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1521655..1522491 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1521655..1522491 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1522498..1523190 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1522498..1523190 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1523187..1523642 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1523187..1523642 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1523649..1523921 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1523649..1523921 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1523910 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1523982..1524755 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1523982..1524755 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1524471..1524478 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1524492..1524510 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1524515 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1524756..1524848 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1524849..1525343 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1524849..1525343 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1525356..1525363 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1525377..1525396 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1525384 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1525406..1525632 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1525406..1525632 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1525599 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1525685..1528450 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1525685..1528450 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1528441 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1528496) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1528531..1528537 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1528552..1528563 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1528552 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1528595..1528969 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1528595..1528969 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1529001..1529005 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1529020 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1529021..1529040 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1529072..1529536 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1529072..1529536 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1529538..1530449 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1529538..1530449 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1530444..1530451 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1530466..1530485 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1530480 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1530489..1530605 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1530489..1530605 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1530632..1531177 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1530632..1531177 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1530826) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1531168 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1531181..1531298 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1531181..1531298 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1531351..1532658 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1531351..1532658 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1532659..1532773 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1532659..1532773 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1532804..1533718 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1532804..1533718 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1533702..1534988 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1533702..1534988 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1534985..1536079 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1534985..1536079 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1536064..1539279 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1536064..1539279 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1539276..1540046 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1539276..1540046 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1540046..1540981 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1540046..1540981 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1540950..1541669 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1540950..1541669 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1541648..1542298 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1541648..1542298 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1542300 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1542345..1542417 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1542397..1542404 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1542418..1542437 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1542419 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1542443..1542548 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1542443..1542548 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1542549..1542709 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1542710..1543411 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1542710..1543411 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1543423..1544487 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1543423..1544487 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1544536..1545684 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1544536..1545684 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1544625) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1544637..1544641) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1544659..1544660) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1545697..1546290 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1545697..1546290 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1546291..1546388 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1546389..1547162 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1546389..1547162 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1547067..1547074 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1547089..1547108 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1547090 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1547165..1547950 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1547165..1547950 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1547931..1548419 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1547931..1548419 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1548399 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1548446) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1548459..1550177) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1548459..1550177) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1550199..1550218) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1550213..1550218 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1550213) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1550231..1550236) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1550234..1550252 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1550238 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1550293..1552965 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1550293..1552965 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1551698..1551717) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1551709) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1551732..1551739) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1552971..1552990 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1552974..1553047 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1552974 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1553048..1553923 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1553048..1553923 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1554000..1554269 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1554000..1554269 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1554080..1554084) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1554085) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1554277..1554891 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1554277..1554891 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1554895..1555098 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1554895..1555098 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1555087 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1555179..1556399 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1555179..1556399 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1556238..1556813) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1556396..1558813 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1556396..1558813 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1556809..1556827) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1556813) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1556841..1556847) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1558664..1558668 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1558684..1558703 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1558695 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1558840..1559322 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1558840..1559322 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1559327..1560280 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1559327..1560280 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1560267..1561610 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1560267..1561610 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1561614..1562705 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1561614..1562705 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1562712..1563476 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1562712..1563476 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1562765 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1563470..1565416 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1563470..1565416 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1565325..1565331 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1565345..1565363 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1565361 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1565431..1566327 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1565431..1566327 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1566332..1566985 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1566332..1566985 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1566983..1566992 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1567006..1567025 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1567011 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1567058..1567702 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1567058..1567702 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1567463..1567469 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1567480 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1567484..1567502 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1567593..1567598 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1567614..1567632 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1567627 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1567703..1567773 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1567774..1567854 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1567774..1567854 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1567869 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1567914..1568286 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1567927..1568115) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1567927..1568115) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1567943) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1567989) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1568116..1568208) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1568190..1568209) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1568208) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1568225..1568228) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1568259..1568266 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1568281..1568299 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1568288 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1568327..1568330 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1568345..1568364 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1568353 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1568392..1568754 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1568392..1568754 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1568605) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1568770..1570431 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1568770..1570431 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1570432..1570521 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1570494..1570501 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1570515..1570534 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1570523 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1570570..1571232 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1570570..1571232 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1571258..1572160 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1571258..1572160 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1572138..1574186 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1572138..1574186 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1574222..1574229 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1574244..1574263 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1574250 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1574295..1574861 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1574295..1574861 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1574875..1575876 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1574875..1575876 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1575895..1576848 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1575895..1576848 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1576841..1577581 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1576841..1577581 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1577612..1577616 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577632..1577651 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577637 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1577665..1577898 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1577665..1577898 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1577879 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1577907..1578007 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1577967..1578037 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1577967 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1578038..1578787 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1578038..1578787 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1578759 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1578829..1578835 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1578847..1578866 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1578869 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1578888..1582448 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1578888..1582448 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1582382..1583452) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1582468..1583457 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1582468..1583457 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1583444 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1583494..1583979) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1583494..1583979) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1583497) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1584001..1584019) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1584017) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1584033..1584040) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1584082..1584088 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1584103..1584122 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1584105 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1584156..1584488 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1584156..1584488 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1584159) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1584502..1585842 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1584502..1585842 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1585843..1585947 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1585948..1586220 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1585948..1586220 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1586220..1586465 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1586220..1586465 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1586437 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1586482..1586586 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1586587..1586973 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1586587..1586973 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1586978..1587502 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1586978..1587502 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1587499..1588230 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1587499..1588230 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1588236..1588243 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1588257..1588276 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1588261 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1588309..1588350 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1588309..1588350 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1588370..1588717 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1588370..1588717 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1588719 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1588772..1588778 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1588791..1588859 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1588791 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1588792..1588811 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1588860..1589708 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1588860..1589708 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1589729..1589736 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1589749..1589767 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1589759 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1589779..1590546 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1589779..1590546 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1590578..1592308 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1590578..1592308 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1591815) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1591816..1591835) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1591850..1591857) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1592305..1592586 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1592305..1592586 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1592418 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1592587..1592706 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1592678..1592685 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1592699..1592718 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1592708 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1592759..1593916 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1592759..1593916 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1592831..1592931) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1592871) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1593945..1594847 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1593945..1594847 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1594837 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1594908..1595801 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1594908..1595801 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1595807..1595814 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1595829..1595848 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1595836..1595988 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1595836 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1595989..1598064 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1595989..1598064 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1598034 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1598096..1598101 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1598108 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1598117..1598135 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1598140..1599447 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1598140..1599447 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1599453..1599457 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1599474..1599493 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1599484 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1599515..1600429 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1599515..1600429 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1599554..1599558 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1599571 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1599574..1599593 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1600442..1600987 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1600442..1600987 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1601004..1602407 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1601004..1602407 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1602447..1603226 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1602447..1603226 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1603201 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1603245 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1603346..1603353 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1603366..1603384 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1603377..1603530 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1603377 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1603505..1603512 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1603527..1603546 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1603532 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1603606..1603995 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1603606..1603995 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1603995..1604447 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1603995..1604447 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" CDS 1604458..1604778 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" /label="fliE CDS" gene 1604458..1604778 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /label="fliE gene" downshifts complement(1604773) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" /label="downshifts" CDS 1604824..1606434 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" /label="fliF CDS" gene 1604824..1606434 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /label="fliF gene" CDS 1606447..1607463 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" /label="fliG CDS" gene 1606447..1607463 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /label="fliG gene" S_feature 1607464..1607581 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1607527..1607627) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1607567) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1607582..1608208 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" /label="fliH CDS" gene 1607582..1608208 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /label="fliH gene" CDS 1608205..1609521 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" /label="fliI CDS" gene 1608205..1609521 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /label="fliI gene" CDS 1609524..1609967 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" /label="fliJ CDS" gene 1609524..1609967 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /label="fliJ gene" CDS 1609979..1610593 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" /label="ylxF CDS" gene 1609979..1610593 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /label="ylxF gene" CDS 1610606..1612069 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" /label="fliK CDS" gene 1610606..1612069 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /label="fliK gene" CDS 1612066..1612488 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" /label="flgD CDS" gene 1612066..1612488 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /label="flgD gene" CDS 1612510..1613304 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" /label="flgE CDS" gene 1612510..1613304 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /label="flgE gene" CDS 1613344..1613559 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" /label="swrD CDS" gene 1613344..1613559 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /label="swrD gene" CDS 1613556..1613978 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" /label="fliL CDS" gene 1613556..1613978 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /label="fliL gene" CDS 1614012..1615010 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" /label="fliM CDS" gene 1614012..1615010 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /label="fliM gene" CDS 1615000..1616136 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" /label="fliY CDS" gene 1615000..1616136 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /label="fliY gene" CDS 1616162..1616524 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" /label="cheY CDS" gene 1616162..1616524 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /label="cheY gene" CDS 1616539..1617198 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" /label="fliZ CDS" gene 1616539..1617198 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /label="fliZ gene" CDS 1617191..1617856 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" /label="fliP CDS" gene 1617191..1617856 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /label="fliP gene" CDS 1617871..1618140 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" /label="fliQ CDS" gene 1617871..1618140 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /label="fliQ gene" CDS 1618148..1618927 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" /label="fliR CDS" gene 1618148..1618927 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /label="fliR gene" CDS 1618927..1620009 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" /label="flhB CDS" gene 1618927..1620009 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /label="flhB gene" CDS 1620042..1622075 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" /label="flhA CDS" gene 1620042..1622075 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /label="flhA gene" CDS 1622075..1623175 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" /label="flhF CDS" gene 1622075..1623175 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /label="flhF gene" promotor_-10 complement(1623052..1623071) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623059) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623085..1623094) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1623166..1624062 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" /label="flhG CDS" gene 1623166..1624062 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /label="flhG gene" CDS 1624064..1625137 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" /label="cheB CDS" gene 1624064..1625137 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /label="cheB gene" CDS 1625143..1627161 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" /label="cheA CDS" gene 1625143..1627161 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /label="cheA gene" CDS 1627183..1627653 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" /label="cheW CDS" gene 1627183..1627653 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /label="cheW gene" CDS 1627672..1628301 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" /label="cheC CDS" gene 1627672..1628301 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /label="cheC gene" CDS 1628298..1628798 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" /label="cheD CDS" gene 1628298..1628798 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /label="cheD gene" CDS 1628821..1629585 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1628821..1629585 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1629595..1629601 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1629614..1630117 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1629614..1630117 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1629616..1629627 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1629630 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1630113..1630119 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1630134..1630153 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1630136..1630260 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1630136 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1630261..1631001 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1630261..1631001 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1630983 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1631028..1631102 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1631103..1631984 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1631103..1631984 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1631985..1632129 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1632130..1632852 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1632130..1632852 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1632854..1633411 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1632854..1633411 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1633358) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1633400..1633403 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1633418..1633437 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1633436..1633541 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1633436 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1633542..1634324 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1633542..1634324 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1634328..1635137 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1634328..1635137 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1635118..1635125 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1635140..1635159 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1635141 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1635199..1636350 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1635199..1636350 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1636357..1637625 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1636357..1637625 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1637658..1639352 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1637658..1639352 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1639353..1639460 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1639461..1643774 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1639461..1643774 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1643775..1643839 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1643785..1644002 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1643785..1644002 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1643811..1643817 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1643832..1643843 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1643841..1643908 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1643841 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1643891..1643897 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1643910..1644103 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1643910 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1643911..1643930 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1644104..1644574 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1644104..1644574 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1644425) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1644609..1645724 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1644609..1645724 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1644671..1644771) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1644711) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1645738..1646013 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1645738..1646013 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1646015..1646317 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1646015..1646317 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1646337..1648487 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1646337..1648487 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1648382..1648388 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1648397 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1648403..1648421 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1648484..1648762 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1648484..1648762 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1648779..1649132 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1648779..1649132 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1649123 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1649214..1650143 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1649214..1650143 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1649928..1649935 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1649949..1649968 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1649958 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1650162..1651112 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1650162..1651112 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1651145..1651151 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1651152..1651268 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1651152 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1651166..1651185 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1651269..1651538 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1651269..1651538 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1651521 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1651566..1651651 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1651632..1651635 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1651651..1651670 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1651653 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1651711..1653828 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1651711..1653828 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1653611 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1653812 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1653857..1653945 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1653946..1654905 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1653946..1654905 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1654014..1654022) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654017) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1654036..1654043) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1654509..1654514 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654530..1654548 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1654535 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1654945..1656174 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1654945..1656174 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1656163 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1656203..1656208 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1656218 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1656224..1656242 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1656252..1656509 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1656252..1656509 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1656510..1656564 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1656537 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1656606..1656615 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1656625..1656694 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1656625 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1656629..1656648 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1656695..1657588 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1656695..1657588 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1657591..1658193 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1657591..1658193 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1658247..1658266 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1658247..1658318 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1658247 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1658319..1659359 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1658319..1659359 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1659360..1659450 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1659451..1660665 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1659451..1660665 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1660696..1661568 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1660696..1661568 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1661039..1662223) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1661575 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1661668..1661671 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1661685 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1661687..1661706 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1661746..1663413 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1661746..1663413 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1662210..1662228) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1662227) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1662244..1662249) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1663401 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1663468..1663474 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1663488..1663499 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1663489 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1663529..1664266 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1663529..1664266 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1664263..1664475 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1664263..1664475 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1664503..1664522 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1664517 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1664606..1666969 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1664606..1666969 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1666970..1667070 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1667031..1667038 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1667053..1667072 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1667071 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1667113..1667838 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1667113..1667838 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1667825 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1667894..1667900 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1667913 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1667915..1667926 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1667977..1669185 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1667977..1669185 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1669143 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1669254..1669261 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1669274..1669293 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1669296 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1669308..1669311 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1669327..1669339 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1669341 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1669365..1670645 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1669365..1670645 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1670642..1671928 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1670642..1671928 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1671778 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1671929..1671982 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1671983..1672711 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1671983..1672711 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1672727..1672733 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1672745 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1672747..1672758 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1672758) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1672769..1672783) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1672792..1672796) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1672792..1673049 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1672792..1673049 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1673034 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1673066) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1673107..1673110 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1673125..1673144 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1673125 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1673179..1673694 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1673179..1673694 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1673630..1673968 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1673630..1673968 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1674035..1674901 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1674035..1674901 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1674098..1674198 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1674158 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1674861 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1674951..1675532 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1674951..1675532 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1675550..1676800 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1675550..1676800 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1676801..1676927 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1676907..1676914 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1676929..1676948 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1676929 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1676973..1678019 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1676973..1678019 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1678031 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1678076..1678141 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1678113..1678122 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1678135..1678150 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1678143 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1678187..1679362 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1678187..1679362 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1679363..1679462 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1679436..1679443 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1679457..1679476 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1679464..1679637 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1679464 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1679638..1681200 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1679638..1681200 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1681177 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1681269..1682063 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1681269..1682063 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1681818..1681823 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1681839..1681857 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1681859 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1682107..1682112 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1682123..1682262 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1682123 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1682128..1682146 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1682155) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1682166..1682179) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1682188..1682192) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1682199) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1682263..1682523 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1682263..1682523 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1682475 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1682507) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1682519 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1682564..1682738 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1682722..1682729 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1682740 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1682744..1682763 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1682789..1683832 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1682789..1683832 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1683845..1685023 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1683845..1685023 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1685005 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1685103..1685106 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1685115 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1685121..1685140 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1685171..1686700 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1685171..1686700 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1686702..1687133 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1686702..1687133 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1687116 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1687264..1687269 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1687285..1687303 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1687293..1687394 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1687293 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1687395..1687940 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1687395..1687940 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1687934 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1687941) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1687998..1688001 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1688016..1688035 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1688020 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1688073..1690649 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1688073..1690649 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1690665..1692548 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1690665..1692548 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1692451..1692945) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1692463 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1692473) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1692695..1692702 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1692717..1692736 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1692727..1692860 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1692727 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1692732..1692882) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1692732..1692882) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1692817 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1692946..1693401) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1692946..1693401) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1693402..1693493) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1693481..1693500) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1693493) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1693517..1693520) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1693556..1694113) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1693556..1694113) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1694204..1694205 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1694256) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1694262..1694618) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1694262..1694618) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1694678..1694691) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1694683) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1694697..1695521) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1694697..1695521) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1695543..1695562) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1695559) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1695574..1695580) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1695632..1696960) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1695632..1696960) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1695639) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1696983..1697002) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697002) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697016..1697024) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1697117..1697124 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1697132..1697151) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1697140..1697159 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697143) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1697146 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697164..1697171) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1697185..1697262 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1697185..1697262 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1697187) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1697240..1697416 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1697240..1697416 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1697397 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1697442..1697630 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1697625..1697644 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1697632 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1697696..1698403 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1697696..1698403 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1698414..1698420 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1698434..1698453 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1698438 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1698473..1698925 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1698473..1698925 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1698913 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1698939..1699292) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1698939..1699292) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1698980) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1699306..1699623) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1699306..1699623) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1699667..1699686) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1699675) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1699701..1699708) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1699760..1700035) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1699760..1700035) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1699761) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1700031..1700036 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1700052..1700070 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1700062..1700081) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1700072 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1700075) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1700094..1700103) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1700124..1700537 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1700124..1700537 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1700588 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1700594..1700613 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1700637..1701581 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1700637..1701581 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1701561..1701569 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1701580..1701598 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1701582 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1701621..1701842 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1701621..1701842 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1701632) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1701694..1701698) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1701698) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1701713..1701718) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1701842 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1702038..1702310 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1702038..1702310 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1702326..1702333 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1702347..1702366 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1702349 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1702392..1702622 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1702392..1702622 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1702623..1702699 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1702656 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1702701..1702808 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1702781..1702788 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1702802..1702821 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1702810 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1702865..1703257 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1702865..1703257 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1703217..1705319 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1703217..1705319 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1705337..1706326 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1705337..1706326 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1706286 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1706340..1706999) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1706355) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1706376..1706996 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1706376..1706996 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1706977 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1707012..1707016 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1707034..1707401 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1707034 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1707038..1707055 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1707044) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1707060..1707827) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1707060..1707827) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1707836..1707855) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707859) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1707868..1707877) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1707981..1707986 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1708002..1708020 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1708002 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1708284..1708289 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1708306..1708324 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1708310..1708450 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1708310 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1708451..1709419 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1708451..1709419 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1709388 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1709483..1709491 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1709498 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1709502..1709521 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1709552..1710814 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1709552..1710814 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1710832..1712097 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1710832..1712097 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1712145..1712152 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1712167..1712186 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1712179 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1712207..1712614 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1712207..1712614 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1712213) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1712595..1712613 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1712620 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1712673) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1712673..1714007 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1712673..1714007 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1713984 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1714029..>1714078 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1714078..1714079 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1714079..1714831 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1714171..1714189) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1714189) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1714205..1714210) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1714832..1716223 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1714832..1716223 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1716254..1717855 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1716254..1717855 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1716370..1716675) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1716670..1716689) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1716675) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1716703..1716711) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1717853 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1717992..1719146) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1717992..1719146) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1717995) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1719045..1719223) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1719191..1719197 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1719206..1719225) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1719207..1719223 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1719217 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1719223) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1719240..1719243) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1719250..1719257 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1719272..1719291 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1719283..1719387 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1719284 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1719388..1720725 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1719388..1720725 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1720726..1720800 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1720757 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1720876..1722375 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1720876..1722375 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1722376..1722691 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1722649 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1722858..1723493) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1722858..1723493) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1723530..1723549) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1723539) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1723564..1723571) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1723681..1723688 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1723703..1723722 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1723705..1723903 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1723705 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1723904..1725319 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1723904..1725319 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1725309 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1725412) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1725421..1726605) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1725421..1726605) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1726606..1726685) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1726678..1726696) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1726689) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1726712..1726717) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1726997..1727004 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1727019..1727038 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1727027 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1727069..1727530 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1727069..1727530 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1727560..1727994 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1727560..1727994 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1727743..1728048) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1727841 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1727995..1729091 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1728050..1728335) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1728093) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1728330..1728349) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728335) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1728361..1728366) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1728597) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1728597..1728857) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1728597..1728857) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1728878..1728897) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728888) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1728910..1728919) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1729092..1729217 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1729092..1729217 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1729218..1729334 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1729261..1729425 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1729261..1729425 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1729309..1729318 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1729332..1729351 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1729336..1729646 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1729336 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1729627..1729634 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1729648..1729667 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1729648 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1729699..1730538 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1729699..1730538 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1729721..1729740) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1729742) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1729755..1729758) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1730498 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1730644) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1730645..1730951) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1730661..1730948) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1730661..1730948) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1730688) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1730775..1730783 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1730797..1730816 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1730799 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1730810..1730970 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1730942 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1730991..1731713) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1730991..1731713) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1730996) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1731738..1731757) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1731746) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1731748..1731872) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1731873..1732229) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1731873..1732229) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1732253..1732272) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1732270) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1732288..1732292) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1732469) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1732475..1732675) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1732475..1732675) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1732658 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1732697..1732716) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1732709) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1732729..1732738) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1732850..1733038) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1732850..1733038) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1732866) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1733007..1733014) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1733020) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1733067..1733086) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733085) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733101..1733108) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1733117..1733254 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1733117..1733254 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1733148..1733153 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1733168..1733186 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1733186..1733288 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1733186 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1733289..1733687 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1733289..1733687 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1733688..1734492 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1733752..1734186) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1733752..1734186) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1733768) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1734216..1734235) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734232) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1734249..1734256) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1734493..1734681 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1734493..1734681 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1734682..1734767 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1734726 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1734796..1734802 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1734814..1734973 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1734814 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1734816..1734827 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1734974..1736536 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1734974..1736536 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1735277..1735296) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735286) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1735311..1735318) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1736566..1737657 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1736566..1737657 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1737647..1738861 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1737647..1738861 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1738939..1738946 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1738961..1738980 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1738972 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1739008..1739814 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1739008..1739814 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1739622..1740720) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1739819..1740436 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1739819..1740436 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1740433..1742073 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1740433..1742073 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1740707..1740726) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1740720) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1740740..1740748) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1741713..1742479) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1742110..1742475 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1742110..1742475 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1742452 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1742472..1742752) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1742472..1742752) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1742481..1742612) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1742524) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1742572..1742581 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1742594..1742603) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1742595..1742614 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1742600 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1742602..1742700 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1742612) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1742614..1742744) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1742701..1743459 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1742701..1743459 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1742734 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1742750..1742769) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1742751) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1742784..1742791) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1743274..1743485) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1743438 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1743483..1744102 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1743486..1744025) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1743486..1744025) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1744026..1744040) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1744032) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1744054..1744060) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1744080..1744089 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1744102..1744117 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1744104 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1744143..1744577 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1744143..1744577 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1744435..1744782 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1744435..1744782 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1744578..1744910 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1744869..1744878 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1744890..1744905 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1744912..1745090 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1744912 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1744981..1745060 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1744981..1745060 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1745047 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1745119..1745736) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1745119..1745736) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1745120) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1745760..1745779) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745781) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1745793..1745800) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1745816..1745823 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1745835 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1745837..1745856 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1745886..1746203 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1745886..1746203 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1745903..1745921) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745906) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1745935..1745942) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1746222..1746875 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1746222..1746875 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1746878..1746885 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1746899..1746918 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1746912 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1746939..1747172 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1746939..1747172 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1747173..1747308 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1747276..1747283 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1747297..1747316 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1747310 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1747341..1749344 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1747341..1749344 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1747545..1747564) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1747562) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1749334 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1749346..1750004) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1749444 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1749445..1749464 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1749497..1749943 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1749497..1749943 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1749967..1749986 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1749975 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1749986..1750003) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750004) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1750022..1750026) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1750029..1750247 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1750029..1750247 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1750259 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1750304..1750603 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1750321..1750494) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1750321..1750494) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1750334) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1750532..1750551) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750539) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1750565..1750572) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1750574..1750582 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1750594..1750613) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1750594..1750612 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1750605..1750713 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1750605 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1750606) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1750628..1750635) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1750714..1751421 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1750714..1751421 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1751441..1751448 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1751460..1751479 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1751468 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1751510..1751872 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1751510..1751872 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1751890..1751893 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1751908..1751927 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1751919 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1751951..1752442 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1751951..1752442 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1752438 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1752473..1752901) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1752473..1752901) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1752490) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1752919..1752938) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1752931) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1752933..1753018) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1752952..1752959) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1752989..1752998 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1753008..1753117 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1753008 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1753011..1753030 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1753013..1753032) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753018) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1753020..1753103) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1753047..1753050) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1753074 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1753135..1753527) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1753135..1753527) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1753148) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1753370..1753375 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1753391..1753409 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1753395 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1753505..1753509 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1753519..1753533 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1753534..1753553) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1753536 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1753549) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753567..1753576) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1753608..1753754) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1753608..1753754) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1753629) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1753786..1753932) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1753786..1753932) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1753932..1754065 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1753932 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1753943..1753945 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1753948..1753959) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753962) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753974..1753980) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1754055..1754062 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1754067..1754159 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1754067 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1754077..1754096 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1754118) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1754160..1756889 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1754160..1756889 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1754180..1754184) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1754184) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1756890..1756960 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1756961..1757473 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1756961..1757473 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1757430 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1757499..1757505 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1757518 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1757520..1757531 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1757554..1757679 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1757554..1757679 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1757572) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1757693..1757699 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1757714..1757725 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1757716 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1757744..1757890 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1757744..1757890 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1757927..1758178 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1757927..1758178 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1758156 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1758199..1758204 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1758218..1758237 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1758222..1758313 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1758222 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1758314..1758679 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1758314..1758679 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1758695..1758994 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1758695..1758994 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1758970 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1759025..1759312) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1759025..1759312) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1759046) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1759112) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1759342..1759361) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1759354) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1759377..1759384) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1759400..1759981) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1759400..1759981) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1759982..1760112 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1760007..1760026) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1760024) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1760097..1760100 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1760114 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1760116..1760135 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1760151..1760558 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1760151..1760558 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1760554 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1760620..1760623 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1760638..1760657 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1760642..1760956 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1760642 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1760957..1762924 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1760957..1762924 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1762928..1765348 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1762928..1765348 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1765328 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1765356..1765545) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1765395..1765571) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1765395..1765571) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1765399) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1765546..1765956) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1765546..1765956) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1765929..1765948) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1765932) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1765963..1765970) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1765997..1766016) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1765998) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1766031..1766038) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1766045..1766064) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1766056) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1766078..1766087) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1766304..1766309 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1766322..1766341 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1766327 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1766340..1766404 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1766405..1767802 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1766405..1767802 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1767791 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1767836 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1767892..1768638) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1768015..1768022 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1768034 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1768035..1768054 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1768105..1769604 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1768105..1769604 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1768637..1768656) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1768660) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1768670..1768679) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1769552 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1769672..1769935 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1769672..1769935 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1770194) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1770194..1771462) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1770194..1771462) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1771463..1771592) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1771593..1773134) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1771593..1773134) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1773135..1773456) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1773446..1773465) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1773457) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1773480..1773483) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1773683..1773690 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1773703..1773722 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1773710 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1773729..1774175 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1773729..1774175 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1774182..1775075 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1774182..1775075 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1774692..1774711 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1774700 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1775148..1775744 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1775148..1775744 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1775734 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1775793..1776992) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1775793..1776992) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1776993..1777064) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1777052..1777063) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1777064) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1777078..1777084) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1777162..1778697) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1777162..1778697) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1777174) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1778708..1779490) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1778708..1779490) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1779511..1780410) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1779511..1780410) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1780425..1780646) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1780425..1780646) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1780661..1781995) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1780661..1781995) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1782005..1783654) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1782005..1783654) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1782054..1782154 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1782114 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1783698..1784840) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1783698..1784840) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1784859..1784877) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1784876) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1784893..1784898) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1784931..1785236) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1784931..1785236) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1785226..1785399) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1785226..1785399) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1785507..1787039) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1785507..1787039) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1785518) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1787074..1787093) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1787074) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1787106..1787115) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1787175..1787567) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1787175..1787567) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1787206) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1787595..1787606) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1787602) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1787620..1787626) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1787674,1787681) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1787675..1787680 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1787681..1787786) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1787771..1787790) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1787786) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1787804..1787811) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1788060..1789535) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1788060..1789535) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1788072) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1789569..1790546) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1789569..1790546) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1790575..1790593) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790587) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1790605..1790613) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1790680..1792071) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1790680..1792071) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1790694) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1790840 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1791861..1791867 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1791881..1791899 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1791892..1792225 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1791892 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1792072..1792176) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1792136..1792236) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1792176) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1792198..1792203 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1792219..1792237 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1792227 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1792285..1792292 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1792305..1792324 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1792308 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1792357..1792902 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1792357..1792902 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1792886 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1792996..1793068) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1792996..1793068) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1793094) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1793121..1793666) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1793121..1793666) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1793706..1793725) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1793720) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1793739..1793746) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1793982..1794212) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1793982..1794212) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1793996) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1794238..1794257) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1794250) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1794269..1794275) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1794304..1794323) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1794314) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1794327..1794334 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1794348..1794367 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1794352 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1794397..1796160 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1794397..1796160 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1796141 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1796261..1797118) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1796261..1797118) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1797164..1797183) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1797184) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1797197..1797204) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1797246..1798235 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1797246..1798235 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1797302..1798260) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1798292..1799773) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1798292..1799773) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1798305) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1799790..1804352) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1799790..1804352) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1802813..1802913 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1802873 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1804353..1804424) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1804404..1804423) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1804421..1804428 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1804424) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1804438..1804445) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1804440 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1804443..1804462 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1804499..1805401 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1804499..1805401 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1805381 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1805453..1806568) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1805453..1806568) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1806565..1807458) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1806565..1807458) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1807463..1807482) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1807471 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1807481) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1807496..1807502) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1807511..1807529) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1807529) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1807545..1807550) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1807606..1807974) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1807606..1807974) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1808009..1808027) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1808032) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1808034..1808153) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1808039..1808047) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1808145..1808164) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1808153) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1808155..1808251) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1808179..1808186) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1808274..1808990) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1808274..1808990) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1808296) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1809028..1809047) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1809037) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1809063..1809066) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1809091..1809097 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1809111..1809129 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1809116 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1809141..1809446 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1809141..1809446 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1809430 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1809517..1810287 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1809517..1810287 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1810269..1810276 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1810288 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1810291..1810310 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1810331..1810864 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1810331..1810864 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1810865..1810950 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1810907 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1810943..1812187) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1810943..1812187) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1810952..1811691 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1810957) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1812188..1812280) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1812281..1813744) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1812281..1813744) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1813762..1814796) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1813762..1814796) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1814808..1814879) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1814851) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1814880..1814971) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1814880..1814971) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1814999..1815018) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1815011) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1815033..1815040) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1815053..1815060 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1815074..1815093 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1815078 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1815120..1817162 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1815120..1817162 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1817170..1817179 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1817192..1817207 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1817195 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1817229..1817522 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1817229..1817522 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1817502 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1817547..1817894) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1817578) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1817895..1818299) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1817895..1818299) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1818300..1818395) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1818385..1818400) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1818385..1818504) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1818385..1818504) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1818395) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1818413..1818422) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1818500..1818506 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1818520..1818531 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1818531..1818739 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1818531 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1818574..1818696 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1818574..1818696 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1818740..1819033 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1818740..1819033 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1819034..1819127 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1819084 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1819149..1820834) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1819149..1820834) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1819161) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1820835..1820922) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1820914..1820932) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820922) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1820946..1820953) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1821091..1821100 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1821110 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1821113..1821132 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1821159..1822610 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1821159..1822610 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1822586 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1822647..1823345) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1822647..1823345) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1822662) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1823380..1823399) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1823399) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1823401..1823614) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1823413..1823420) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1823615..1824292) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1823615..1824292) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1824293..1826782) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1824465..1825502 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1824465..1825502 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1825699..1825705 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1825720..1825731 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1825732 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1825759..1826442 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1825759..1826442 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1826783..1827088) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1826783..1827088) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1827089..1827190) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1827169..1827188) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827190) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1827203..1827210) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1827218..1827320) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1827260) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1827321..1828499) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1827321..1828499) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1828525..1828544) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828544) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1828558..1828567) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1828622..1829110) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1828622..1829110) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1828647) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1829135..1829290) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1829135..1829290) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1829330..1830085) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1829330..1830085) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1830338..1830343 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1830359..1830377 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1830374 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1830393..1830749 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1830393..1830749 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1830708..1830947) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1830708..1830947) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1830750..1831186 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1830948..1831049) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1831050..1831547) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1831050..1831547) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1831548..1831647) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1831648..1832559) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1831648..1832559) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1832581..1832592) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1832583) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1832607..1832613) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1832843..1832850 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1832859 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1832865..1832884 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1832906..1833388 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1832906..1833388 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1833398..1833652 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1833398..1833652 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1833653..1833757 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1833758..1834552 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1833758..1834552 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1834553..1835563 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1834676..1835548) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1834676..1835548) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1835649..1836527 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1835649..1836527 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1836640..1836699) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1836675) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1836700..1837131) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1836700..1837131) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1837151..1837170) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1837159) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1837161..1837394) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1837184..1837190) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1837395..1837413) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1837395..1838027) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1837395..1838027) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1837401) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1837429..1837434) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1838165..1838172 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1838187..1838206 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1838191 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1838253..1839173 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1838253..1839173 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1838684..1838703) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838699) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1838718..1838725) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1839174..1839831 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1839670..1840032) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1839670..1840032) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1840093..1840305) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1840093..1840305) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1840344..1840351 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1840366..1840385 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1840369 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1840409..1840672 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1840409..1840672 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1840650 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1841049..1843649) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1841049..1843649) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1843650..1843759) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1843675..1843682 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1843697..1843716 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1843705..1844332 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1843705 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1843749..1843768) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1843759) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1843783..1843789) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1843805..1844264) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1843847) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1844309) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1844319..1844960) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1844319..1844960) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1844961..1845078) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1845055..1845074) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845078) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1845088..1845090) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1845166,1845173) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1845167..1845172 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1845173..1845257 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1845173..1845250 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1845173..1845237) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1845173..1845257 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1845235 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1845268..1845600) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1845268..1845600) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1845282) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1845665..1846390) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1845665..1846390) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1846405..1847148) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1846405..1847148) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1847176..1847195) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1847195) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1847209..1847215) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1847226..1847801) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1847226..1847801) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1847807..1848508) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1847807..1848508) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1848538..1848557) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848538) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1848542..1848557) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1848572..1848579) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1848572..1848579) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1848582) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1848585..1849067) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1848585..1849067) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1849106..1849123) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1849110) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1849121..1850062) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1849121..1850062) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1849154) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1850092..1850111) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1850100) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1850125..1850129) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1850133..1850142 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1850155..1850174 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1850163 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1850178..1850242 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1850214..1850219 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1850235..1850253 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1850244 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1850268..1850813 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1850268..1850813 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1850772 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1850840..1851163) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1850840..1851163) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1850847) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1851184..1851203) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1851195) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1851216..1851223) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1851284..1851290 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1851301 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1851305..1851324 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1851357..1852034 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1851357..1852034 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1852026 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1852124..1852660) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1852124..1852660) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1852147) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1852687..1852706) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1852707) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1852720..1852727) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1852797..1853579) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1852797..1853579) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1852806) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1853601..1853619) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1853620) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1853633..1853639) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1853676..1853683 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1853698..1853717 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1853702 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1853750..1854247 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1853750..1854247 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1854254..1854257 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1854273..1854292 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1854275 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1854311..1855288 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1854311..1855288 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1855260 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1855385..1855392 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1855407..1855426 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1855414 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1855450..1856508 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1855450..1856508 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1856509..1856578 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1856562..1856568 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1856580..1856599 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1856580 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1856628..1857740 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1856628..1857740 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1857759..1858358 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1857759..1858358 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1858296 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1858340 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1858380..1858878) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1858416) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1858850..1858859 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1858862..1858880) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1858871..1859065 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1858871 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1858872..1858891 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1858878) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1858897..1858902) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1858953..1859816) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1858953..1859816) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1858966) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1859022 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1859054) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1859067..1859834 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1859812..1859816 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1859825..1859839 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1859836 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1859855..1859874) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859868) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1859870..1860063) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1859886..1859892) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1860064..1861839) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1860064..1861839) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1861840..1861970) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1861963..1862165) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1861963..1862165) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1862015) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1862163..1862182) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1862181) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1862183..1862375) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1862195..1862202) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1862404..1863030) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1862404..1863030) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1862420) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1863064..1863083) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1863077) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1863097..1863104) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1863181..1863672) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1863181..1863672) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1863190) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1863684..1863702) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1863696) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1863716..1863722) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1863747..1864079) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1863747..1864079) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1864080..1864370) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1864095..1864100 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1864115..1864133 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1864117 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1864157..1864384 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1864157..1864384 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1864371..1864847) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1864371..1864847) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1864385..1864892 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1864848..1864950) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1864865..1864870 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1864885..1864903 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1864894 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1864914..1865177 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1864914..1865177 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1864930..1864949) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1864950) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1864952..1865477) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1864963..1864967) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1865182..1865415 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1865182..1865415 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1865402 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1865501..1865845) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1865501..1865845) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1865522) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1865846..1865918) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1865914..1865933) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1865918) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1865920..1866023) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1865947..1865952) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1866010..1866025) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866023) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1866038..1866047) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1866166) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1866202..1866405) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1866202..1866405) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1866426..1866445) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866444) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1866446..1866512) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1866461..1866468) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1866478..1866485 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1866497 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1866499..1866511) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1866499..1866518 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1866502..1866634 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1866523) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1866635..1868122 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1866635..1868122 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1867078..1867095) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1867084) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1867108..1867116) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1868108 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1868170..1868175 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1868191..1868209 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1868196 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1868223..1870121 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1868223..1870121 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1869166..1869185) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1869174) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1869199..1869208) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1870111..1870956 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1870111..1870956 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1870957..1872463 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1870989..1872326) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1870989..1872326) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1871000) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1872354..1872373) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1872369) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1872371..1873529) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1872388..1872395) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1872447..1872450 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1872465..1872484 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1872465 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1872545..1873510 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1872545..1873510 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1873498 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1873560..1874813) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1873560..1874813) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1873574) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1874829..1877663) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1874829..1877663) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1877758..1877777) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1877773) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1877775..1877891) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1877792..1877799) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1877892..1879808) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1877892..1879808) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1879819..1880733) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1879819..1880733) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1880737..1880756) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1880752) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1880773..1880777) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1880797..1881387) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1880797..1881387) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1881480..1882724) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1881480..1882724) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1881482) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1882787..1882805) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1882800) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1882802..1883022) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1882818..1882825) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1883008..1883026) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1883022) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1883038..1883046) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1883106..1884323) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1883106..1884323) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1883132) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1884356..1884375) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1884364) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1884389..1884396) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1884559..1885182) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1884559..1885182) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1885183..1885333) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1885209..1885215 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1885221 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1885229..1885240 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1885247..1885255 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1885263..1885363 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1885267..1885285 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1885278 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1885316..1885334) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1885323..1885408 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1885323 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1885333) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1885350..1885356) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1885384..1885391 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1885404..1885423 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1885410 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1885448..1886806 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1885448..1886806 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1885790..1885801) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1885795) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1885815..1885821) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1886822..1887670 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1886822..1887670 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1887086..1887105) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1887093) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1887119..1887127) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1887633 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1887665) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1887696..1888361) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1887696..1888361) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1887710) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1888380..1888730) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1888380..1888730) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1888727..1889005) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1888727..1889005) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1889032..1889051) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1889048) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1889066..1889072) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1889081..1889977) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1889081..1889977) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1889819..1889828 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1889839 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1889842..1889861 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1889857..1890075 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1890001..1890020) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1890021) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1890032..1890039) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1890076..1890549 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1890076..1890549 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1890546 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1890584..1890820) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1890584..1890820) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1890592) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1890843..1890862) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1890858) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1890876..1890885) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1890905..1892239) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1890905..1892239) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1892240..1892375) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1892372..1892391) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1892382) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1892406..1892413) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1892471..1892478 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1892493..1892512 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1892496 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1892497..1892603 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1892604..1892993 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1892604..1892993 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1893003 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1893400..1893738) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1893400..1893738) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1893761..1893768 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1893782..1893801 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1893791 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1893795..1893867 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1893826..1893845) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1893829) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1893857..1893863) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1893868..1894476 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1893868..1894476 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1894466 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1894519..1895121) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1894519..1895121) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1895137..1896048) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1895137..1896048) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1896077..1896096) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1896093) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1896112..1896117) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1896169..1896172 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1896187..1896206 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1896189 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1896232..1896432 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1896232..1896432 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1896432..1897922 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1896432..1897922 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1897167..1897178) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1897171) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1897192..1897198) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1897910 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1897957..1899357) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1897957..1899357) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1897981) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1899128..1899137 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1899149..1899164 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1899163 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1899377..1899396) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1899397) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1899410..1899417) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1899456..1899465 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1899471 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1899478..1899497 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1899510..1900211 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1899510..1900211 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1900236..1900244 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1900258..1900277 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1900263 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1900299..1900550 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1900299..1900550 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1900571 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1900621..1901442) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1900621..1901442) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1900647) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1901443..1901524) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1901525..1902226) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1901525..1902226) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1902227..1902316) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1902301..1902320) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1902316) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1902336..1902340) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1902374..1902380 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1902395..1902406 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1902412 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1902428..1902553 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1902428..1902553 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1902551 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1902593..1902907) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1902593..1902907) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1902605) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1902928..1902946) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1902935) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1902957..1902965) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1902968..1903579) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1902968..1903579) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1903657..1903833) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1903657..1903833) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1903661) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1903672) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1903676..1903695) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1903711..1903714) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1903847..1903865) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1903868) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1903870..1904091) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1903881..1903886) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1903891..1903896 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1903911..1903929 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1903913 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1903952..1904095 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1903952..1904095 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1904092..1904772) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1904092..1904772) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1904096..1905107 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1904799..1904818) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1904805) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1904832..1904841) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1904923..1905147) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1904923..1905147) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1904937) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1905188..1905207) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1905200) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1905234..1905512) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1905234..1905512) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1905509..1906924) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1905509..1906924) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1906180..1906183 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1906199..1906218 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1906204 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1906953..1907780) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1906953..1907780) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1907758..1909068) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1907758..1909068) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1909077..1909730) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1909077..1909730) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1909715..1910404) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1909715..1910404) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1910411..1911745) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1910411..1911745) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1911726..1911881) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1911726..1911881) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1911764..1911782) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1911780) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1911798..1911803) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1911875..1912108) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1911875..1912108) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1911882) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1911984..1911988 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1911997..1912011 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1912012 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1912013..1912032) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1912022) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1912047..1912056) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1912068..1912847) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1912068..1912847) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1912876..1914156) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1912876..1914156) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1913524..1913542) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1913540) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1913556..1913563) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1914124..1914142) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1914134) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1914158..1914163) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1914221..1914526) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1914221..1914526) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1914354) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1914550..1914569) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1914565) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1914583..1914592) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1914662..1914671 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1914685..1914704 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1914685 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1914706) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1914708..1914722) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1914731..1914735) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1914731..1915132 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1914731..1915132 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1915139..1916092 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1915139..1916092 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1916082 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1916163..1917311) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1916163..1917311) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1916180) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1917324..1917328 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1917337..1917356) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1917344..1917363 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1917346) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1917354 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1917615..1917623 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1917637..1917656 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1917640 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1917681..1918706 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1917681..1918706 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1918084 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1918086..1918090 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1918100..1918101 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1918698 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1918750..1919181) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1918750..1919181) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1918755) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1919182..1919715) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1919182..1919715) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1919719..1919725 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1919736..1919846 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1919736 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1919738..1919757 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1919743..1919762) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1919763) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1919778..1919779) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1919847..1920272 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1919847..1920272 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1920260 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1920305..1921536 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1920322..1921659) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1920322..1921659) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1921731..1921925) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1921731..1921925) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1921744) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1921938..1922501) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1921938..1922501) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1922511..1923278) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1922511..1923278) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1923302..1923321) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1923319) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1923332..1923339) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1923356..1923937) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1923356..1923937) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1923938..1924053) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1924085..1924336) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1924085..1924336) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1924098) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1924359..1924378) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1924373) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1924422..1925690) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1924422..1925690) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1925724..1925743) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925743) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1925755..1925762) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1925897..1925916 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1925900 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1925939..1926934 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1925939..1926934 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1926955..1927596 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1926955..1927596 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1927597..1928698 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1927635..1928255) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1927635..1928255) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1927661) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1928256..1928762) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1928256..1928762) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1928759..1929553) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1928759..1929553) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1929637..1930170) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1929637..1930170) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1929642) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1930100..1930105 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1930116..1931062 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1930118 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1930122..1930140 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1930188..1930799) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1930188..1930799) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1930831..1930850) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1930850) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1930863..1930868) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1931019 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1931059..1931832) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1931059..1931832) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1931094) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1931874..1932308) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1931874..1932308) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1931886) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1932337..1932356) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1932348) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1932350..1932414) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1932370..1932377) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1932393) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1932415..1934091) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1932415..1934091) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1934092..1934282) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1934271..1934290) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1934282) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1934305..1934308) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1934380..1935513) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1934380..1935513) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1934396) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1935535..1935554) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1935538) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1935573..1936190) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1935573..1936190) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1936206..1936688) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1936206..1936688) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1936689..1936836) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1936827..1936845) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1936837) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1936856..1936864) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1936890..1936899 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1936912..1936927 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1936914..1937000 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1936914 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1936963..1936970 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1936985..1937004 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1937002 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1937031..1937936 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1937031..1937936 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1937971..1937990 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1937985 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1937986..1938166 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1938167..1939315 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1938167..1939315 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1938336..1939365) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1939311 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1939347..1939366) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1939365) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1939381..1939389) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1939396..1939542 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1939396..1939542 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1939435..1939442 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1939456..1939475 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1939467..1939557 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1939467 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1939558..1939758 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1939558..1939758 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1939773 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1939810..1939992) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1939810..1939992) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1939818..1940123 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1939827) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1940053..1940071) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1940085..1940091) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1940089) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1940099..1940105 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1940120..1940131 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1940125 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1940148..1940417 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1940148..1940417 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1940272 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1940400 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1940445..1940627) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1940445..1940627) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1940465) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1940620..1941300) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1940620..1941300) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1941301..1941438) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1941317..1941322 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1941335..1941354 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1941340 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1941383..1942072 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1941383..1942072 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1941436..1941452) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1941439) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1941440..1941829) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1941810..1941829) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1941827) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1941841..1941849) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1942072..1942470 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1942072..1942470 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1942463..1942469 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1942484..1942495 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1942495 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1942512..1942640 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1942512..1942640 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1942641..1943621 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1942648..1943538) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1942648..1943538) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1942685) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1943560..1943579) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1943567) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1943591..1943597) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1943595 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1943639..1943785) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1943639..1943785) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1943655) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1943809) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1943810..1943821) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1943836..1943842) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1943860..1944117) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1943860..1944117) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1944137..1944156) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1944152) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1944168..1944175) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1944182..1947763) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1944182..1947763) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1947764..1947835) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1947825..1947844) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1947835) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1947880..1948077) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1947923) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1947939..1948028) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1947939..1948028) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1948056..1948075) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948077) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1948090..1948097) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1948099..1948605) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1948099..1948605) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1948609..1949706) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1948609..1949706) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1949724..1949735) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949727) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949750..1949756) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1949780..1951096) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1949780..1951096) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1949793) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1951093..1951677) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1951093..1951677) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1951766..1951866) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1951766..1951866) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1951773) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1951867..1952007) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1952008..1953513) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1952008..1953513) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1953449..1953549) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1953489) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1953501 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1953539..1953558) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953555) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1953572..1953579) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1953625..1954617) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1953625..1954617) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1953643) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1954662..1955252) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1954662..1955252) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1955254..1956228) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1955254..1956228) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1956266..1957285) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1956266..1957285) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1957333..1957352) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1957343) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1957364..1957371) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1957406..1957413 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1957427..1957506 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1957427 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1957428..1957447 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1957507..1958334 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1957507..1958334 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1958336..1959100 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1958336..1959100 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1959089 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1959131) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1959141..1961066) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1959141..1961066) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1961097..1961116) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961101) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1961103..1961167) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1961131..1961135) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1961168..1961359) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1961168..1961359) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1961378..1961396) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961387) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1961389..1961694) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1961412..1961417) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1961426..1961432 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1961447..1961458 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1961456 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1961523..1961675 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1961523..1961675 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1961685 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1961728..1962885) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1961728..1962885) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1961739) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1962973..1963373) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1962973..1963373) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1962983) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1963370..1963389) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1963388) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1963404..1963410) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1963432..1963728) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1963432..1963728) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1963753..1963772) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1963763) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1963786..1963793) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1963806..1964435) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1963806..1964435) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1964401) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1964437..1964664) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1964437..1964664) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1964692..1964711) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1964707) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1964709..1964863) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1964725..1964733) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1964748..1964876) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1964748..1964876) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1964863) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1964865..1964976) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1964866..1964885) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1964901..1964905) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1964977..1966218) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1964977..1966218) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1965932..1965950) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1965941) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1965965..1965972) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1966234..1968483) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1966234..1968483) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1968499..1968518) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1968515) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1968532..1968538) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1968586..1969092) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1968586..1969092) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1968609) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1969136..1969155) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1969153) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1969169..1969176) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1969174..1969183 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1969197..1969216 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1969209 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1969230..1969649 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1969230..1969649 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1969650..1969800 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1969670..1970047) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1969670..1970047) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1969703) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1970045..1970190 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1970077..1970095) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1970096) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1970109..1970118) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1970191..1970210 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1970192 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1970235..1970423 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1970235..1970423 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1970439 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1970462..1970833) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1970462..1970833) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1970495) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1970845..1970864) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1970858) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1970877..1970882) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1970879..1971124) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1970879..1971124) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1971150..1971168) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1971155) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1971180..1971188) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1971274..1971280 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1971295..1971306 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1971302 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1971323..1971427 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1971323..1971427 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1971409 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1971452..1972414) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1971452..1972414) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1971582..1971591 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1971603..1971618 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1971603 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1971607..1971942 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1971913..1971917 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1971933..1971952 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1971944..1972454 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1971944 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1972415..1972871) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1972455..1973075 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1972455..1973075 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1972860..1972871) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1972871) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1972886..1972892) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1973097..1975841 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1973097..1975841 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1975511) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1975827 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1975917..1976411) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1975917..1976411) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1975930) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1976408..1977067) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1976408..1977067) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1977086..1977784) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1977086..1977784) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1977785..1977876) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1977877..1979169) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1977877..1979169) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1979170..1979231) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1979231..1979250) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1979231) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1979265..1979272) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1979313..1980494) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1979313..1980494) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1979317) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1980517..1981002) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1980517..1981002) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1980950..1980969) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1980967) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1980982..1980989) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1981011..1981181) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1981011..1981181) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1981182..1981253) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1981215..1981221 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1981236..1981255) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1981236..1981247 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1981243..1981317 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1981243 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1981253) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1981255..1981323) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1981271..1981277) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1981287 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1981324..1984119) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1981324..1984119) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1981792..1981796 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1981793 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1981798..1981802 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1982449..1982464) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1982463) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1982477..1982486) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1984120..1984244) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1984245..1984628) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1984245..1984628) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1984630..1985490) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1984630..1985490) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1985492..1986325) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1985492..1986325) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1986326..1986533) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1986528..1986547) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1986533) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1986564..1986568) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1986571..1987548) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1986571..1987548) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1987533..1988726) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1987533..1988726) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1988731..1989864) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1988731..1989864) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1989861..1990571) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1989861..1990571) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1990564..1990977) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1990564..1990977) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1990993..1991796) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1990993..1991796) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1991808..1992143) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1991808..1992143) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1992163..1992182) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1992173) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1992196..1992203) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1992212..1992219 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1992228..1992247) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1992233..1992252 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1992239 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1992247) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1992283..1993155 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1992283..1993155 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1993197..1993991) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1993197..1993991) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1993222) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1993992..1994059) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1994060..1994617) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1994060..1994617) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1994618..1994697) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1994742) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1994764..1995531) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1994764..1995531) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1995566..1996240) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1995566..1996240) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1996242..1996745) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1996242..1996745) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1996754 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1996809..1996828) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1996809) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1996843..1996850) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1996888..1997334) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1996888..1997334) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1997337 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1997389..1997928) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1997389..1997928) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1997402) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1997961..1997979) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1997972) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1997991..1997999) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1998000..1999271) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1998000..1999271) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1999272..1999339) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1999336..1999355) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999339) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1999369..1999376) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1999406..1999425) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1999412) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1999414..1999558) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1999436..1999443) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1999540..1999558) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1999558) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1999574..1999579) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1999607..2000893) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1999607..2000893) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1999630) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2000904..2002019) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(2000904..2002019) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(2002068..2003150) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(2002068..2003150) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(2003161..2003964) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(2003161..2003964) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(2003649..2003668) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2003666) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(2003680..2003687) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2003957..2005159) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(2003957..2005159) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(2005140..2005787) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(2005140..2005787) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(2005234) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(2005410..2005413) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2005410) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(2005630) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 2005792..2006544 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(2005792..2006544) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(2005792..2006544) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(2005825..2005827) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2005828 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(2005934,2005937) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2005948,2005950) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2005950,2005952) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2005975,2005977) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2005977,2005981) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2005983,2005985) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2005992,2005994) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006007,2006009) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006010,2006012) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006015,2006017) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006025,2006027) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006028,2006030) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006031,2006033) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006037,2006039) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006063,2006065) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006095,2006097) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006148,2006150) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006196,2006198) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006211,2006215) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006229,2006231) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006238,2006240) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006250,2006252) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006315,2006317) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006325,2006327) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006333,2006336) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006353,2006355) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006369,2006371) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006397,2006399) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006412,2006414) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006437,2006439) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006454,2006456) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2006469,2006471) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(2006537..2007553) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(2006537..2007553) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(2007525..2009072) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(2007525..2009072) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(2009151..2009282) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(2009194) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2009273..2009292) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(2009282) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(2009288..2009671) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(2009288..2009671) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(2009307..2009314) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(2009668..2010756) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(2009668..2010756) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(2009797..2009812) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2009810) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(2009825..2009833) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2010756..2011928) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(2010756..2011928) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(2011963..2011982) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2011980) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2011995..2012002) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2012003..2012773) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(2012003..2012773) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(2012799..2012818) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2012816) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2012830..2012836) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(2012848..2013009) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(2012891) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(2013010..2013459) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(2013010..2013459) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(2013502..2013521) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2013509) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(2013534..2013541) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2013575..2014621) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(2013575..2014621) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(2014563..2015264) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(2014563..2015264) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(2015271..2016026) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(2015271..2016026) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(2016027..2016112) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(2016101..2016120) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2016112) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2016131..2016138) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2016190..2016417) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(2016190..2016417) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(2016211) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(2016439..2017011) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(2016439..2017011) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(2017040..2017059) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2017050) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(2017052..2017135) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(2017072..2017078) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(2017180) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(2017199..2017477) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(2017199..2017477) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(2017478..2017703) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(2017685..2017704) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2017703) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2017721..2017726) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2017851..2019329) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(2017851..2019329) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(2017864) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2019330..2019491) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(2019478..2019496) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(2019503) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(2019510..2020244) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(2019510..2020244) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(2019511..2019516) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(2019536) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(2020266..2020469) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(2020266..2020469) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(2020505..2020524) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2020526) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2020538..2020545) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2020591..2020790) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(2020634) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2020765..2020784) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2020790) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2020798..2020807) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2020807..2021844) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(2020807..2021844) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(2021862..2023172) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(2021862..2023172) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(2023173..2023297) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(2023283..2023302) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2023297) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2023317..2023320) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2023326..2023520) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(2023326..2023520) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(2023517..2024410) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(2023517..2024410) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(2024407..2025006) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(2024407..2025006) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 2024879..2024885 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2024894..2025077 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 2024896 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2024899..2024910 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2025017..2025035) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025036) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2025051..2025056) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2025084..2025215 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 2025084..2025215 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 2025203 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2025258..2026307) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(2025258..2026307) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(2025278) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2026182) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(2026320..2027468) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(2026320..2027468) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 2026649..2026652 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2026676 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2026742 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2027446 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(2027469..2027608) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(2027607..2027626) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2027608) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2027610..2027700) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(2027641..2027648) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2027701..2028375) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(2027701..2028375) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(2028376..2028453) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(2028454..2028630) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(2028454..2028630) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(2028642..2028660) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2028659) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2028675..2028681) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2028675..2029328) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(2028675..2029328) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(2029358..2029377) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2029371) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2029393..2029397) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2029421..2030773) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(2029421..2030773) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(2029436) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2030808..2031725) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(2030808..2031725) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(2031196) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(2031347..2031354) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2031350) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2031763..2031774) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031772) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2031788..2031794) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2031864..2032520) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(2031864..2032520) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(2031878) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2032545..2032564) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2032560) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2032640..2033614) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(2032640..2033614) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(2032648) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 2033468..2033473 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2033489..2033507 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2033499..2033692 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2033499 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 2033650 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2033723..2035006) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(2033723..2035006) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(2033726) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 2033764..2033770 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2033782..2033786 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2033782 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2035049..2035068) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035070) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2035083..2035090) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2035162..2035746) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(2035162..2035746) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(2035164) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(2035747..2035828) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2035821..2035840) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2035828) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(2035854..2035861) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2035905..2036684) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(2035905..2036684) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(2036710..2036725) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2036721) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(2036737..2036746) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2036770..2037213) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(2036770..2037213) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(2036787) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2037276..2037998) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(2037276..2037998) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(2037557) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(2037949..2038518) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(2037949..2038518) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(2038267..2038285) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2038283) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2038300..2038306) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2038537..2039283 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2038578..2040068) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(2038578..2040068) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(2040061..2041119) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(2040061..2041119) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 2040409..2040418 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2040429..2041219 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2040429 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2040431..2040450 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2041160..2041179) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2041183) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2041191..2041198) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2041197..2041203 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2041217..2041236 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2041221..2041290 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2041221 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 2041270..2041277 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2041292..2041384 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2041292..2041311 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2041292 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 2041385..2041633 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 2041385..2041633 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 2041617 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2041673..2042245) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(2041673..2042245) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(2041693) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2042237..2042544) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(2042237..2042544) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(2042246..2042350) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2042543..2042562) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042559) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2042576..2042582) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2042671..2042678 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2042689 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2042693..2042712 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2042742..2044319 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 2042742..2044319 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 2044301 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(2044362..2045129) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(2044362..2045129) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(2044377) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 2044631..2045243 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2045156..2045175) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2045169) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2045190..2045193) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2045203 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(2045241..2046347) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(2045241..2046347) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(2045258) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(2046283..2046867) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(2046283..2046867) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 2046661..2046666 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2046677 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2046681..2046685 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2046818..2046823 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2046835 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2046839..2046857 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2046875 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2046916..2046935) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2046920..2047027 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2046924) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2046948..2046955) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2046983 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2047012..2047070) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2047043) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2047071..2048840) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(2047071..2048840) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(2047127) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2048837..2049559) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(2048837..2049559) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(2049560..2049639) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2049640..2050815) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(2049640..2050815) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(2050835..2052463) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(2050835..2052463) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(2052460..2052999) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(2052460..2052999) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(2053000..2053093) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2053094..2053828) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(2053094..2053828) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(2053837..2053856) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2053860) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2053871..2053875) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2053920..2054456) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(2053920..2054456) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(2053925..2053944) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2053929) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2053959..2053966) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2054461..2055051) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(2054461..2055051) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(2055039..2056187) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(2055039..2056187) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(2056209..2056227) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2056216) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2056242..2056247) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2056310..2056849) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(2056310..2056849) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(2056323) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2056858..2056875) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2056873) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2056890..2056895) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2056904..2057497) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(2056904..2057497) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(2057487..2058242) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(2057487..2058242) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 2058086..2058095 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2058108..2058127 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2058117 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2058288..2058307) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2058303) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2058321..2058328) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2058468..2058475 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2058486..2058505 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2058491 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 2058523..2059047 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 2058523..2059047 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(2059061..2059435) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(2059061..2059435) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(2059077) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2059497..2059516) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2059509) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2059528..2059535) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2059548..2060012) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(2059548..2060012) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 2059883..2059887 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2059901..2059905 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2059904 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2060045..2061241) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(2060045..2061241) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(2061256..2061903) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(2061256..2061903) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(2061914..2062999) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(2061914..2062999) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(2063000..2063128) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2063129..2063273) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(2063129..2063273) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(2063290..2063309) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063300) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2063324..2063331) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2063393..2063737) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(2063393..2063737) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(2063408) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2063769..2063787) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063782) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2063796..2063801 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2063802..2063808) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2063816..2064738 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2063816 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2063817..2063835 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2063823..2063838) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063826) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2063828..2063894) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2063851..2063860) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2063889..2063897) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063894) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2063911..2063919) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2063972..2064526) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(2063972..2064526) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(2063982) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2064552..2064571) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2064570) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2064572..2064971) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2064583..2064589) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2064793..2065029 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 2064793..2065029 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(2064972..2065178) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(2064972..2065178) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(2065211..2065230) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2065233) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(2065287..2065541) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(2065287..2065541) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 2065421..2065430 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2065432..2065821) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(2065432..2065821) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 2065444..2066515 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2065444..2065463 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2065444 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2065799..2066002) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(2065799..2066002) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 2066411..2066527 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 2066411..2066527 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 2066478 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 2066604..2066613 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2066626..2066645 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2066626 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 2066668..2066880 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 2066668..2066880 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 2066874 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(2067016) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2067016..2067447) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(2067016..2067447) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(2067448..2067534) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2067517..2067536) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2067534) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2067550..2067555) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2067584..2067593 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2067603..2067700 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2067603 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2067606..2067621 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2067701..2068573 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 2067701..2068573 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 2068480 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2068546 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2068603..2069922) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(2068603..2069922) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(2068623) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2069923..2069987) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2069983..2070002) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2069987) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2070017..2070024) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2070028..2071509) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" /label="spoVAF CDS" gene complement(2070028..2071509) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /label="spoVAF gene" misc_feature complement(2070734..2070753) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2070738) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2071460..2072071) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" /label="spoVAEA CDS" gene complement(2071460..2072071) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /label="spoVAEA gene" CDS complement(2072079..2072429) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" /label="spoVAEB CDS" gene complement(2072079..2072429) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /label="spoVAEB gene" CDS complement(2072431..2073447) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" /label="spoVAD CDS" gene complement(2072431..2073447) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /label="spoVAD gene" promotor_-35 2072927..2072934 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2072948..2072967 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2072970 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2073460..2073912) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" /label="spoVAC CDS" gene complement(2073460..2073912) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /label="spoVAC gene" CDS complement(2073925..2074350) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" /label="spoVAB CDS" gene complement(2073925..2074350) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /label="spoVAB gene" CDS complement(2074340..2074960) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" /label="spoVAA CDS" gene complement(2074340..2074960) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /label="spoVAA gene" promotor_-10 complement(2074991..2075002) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2075001) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2075016..2075022) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2075085..2075852) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" /label="sigF CDS" gene complement(2075085..2075852) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /label="sigF gene" downshifts complement(2075115) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2075864..2076304) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" /label="spoIIAB CDS" gene complement(2075864..2076304) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /label="spoIIAB gene" CDS complement(2076301..2076654) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" /label="spoIIAA CDS" gene complement(2076301..2076654) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /label="spoIIAA gene" promotor_-10 complement(2076679..2076697) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2076690) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2076692..2076749) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2076709..2076717) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2076750..2077919) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(2076750..2077919) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(2077948..2077959) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2077963) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2077973..2077979) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2078065) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2078074..2078889) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(2078074..2078889) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(2078902..2080086) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(2078902..2080086) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(2080135..2080154) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2080153) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2080155..2080246) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2080170..2080177) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2080247..2081137) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(2080247..2081137) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(2081145..2081372) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(2081145..2081372) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(2081275..2081294) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2081286) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2081308..2081315) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2081365) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2081374..2081392) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2081402..2081420) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2081408..2081414) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2081415) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2081437..2081442) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2081497) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(2081497..2081946) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(2081497..2081946) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(2081970..2081989) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2081980) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(2081982..2082058) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2082005..2082009) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2082059..2082703) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(2082059..2082703) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(2082734..2082752) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2082751) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(2082767..2082772) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2082804..2083019) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(2082804..2083019) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(2082884) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2083119..2084438) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(2083119..2084438) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(2083126) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(2084456..2085862) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(2084456..2085862) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(2085910..2085929) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085919) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2085921..2086002) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2085944..2085951) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2086003..2087430) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(2086003..2087430) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(2087475..2088464) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(2087475..2088464) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(2088465..2088544) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2088526..2088545) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2088544) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2088546..2088866) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2088560..2088567) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2088585..2088592 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2088605..2088624 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2088607 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 2088646..2088996 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 2088646..2088996 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(2088868..2089004) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2088911) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(2089005..2090168) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(2089005..2090168) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(2090165..2090722) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(2090165..2090722) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(2090652..2090752) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2090692) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2090736..2090741 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2090757..2090775 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2090759..2090773) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2090763 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 2090770..2090944 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2090775..2090778) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2090778) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 2090797..2090919 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 2090797..2090919 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 2090920..2090927 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2090941..2090960 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2090946 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 2090982..2091902 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 2090982..2091902 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 2091891 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2091934..2092158) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(2091934..2092158) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(2091991) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2092181..2092200) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092188) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2092215..2092222) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2092237..2092244 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2092259..2092278 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2092266 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 2092320..2093237 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 2092320..2093237 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 2093212 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(2093277..2093516) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(2093277..2093516) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(2093288) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2093529..2093852) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(2093529..2093852) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(2093595..2093614) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093596) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2093628..2093635) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2093849..2094880) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(2093849..2094880) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(2093876..2093895) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093883) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2093906..2093913) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2094873..2095217) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(2094873..2095217) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(2095227..2095697) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(2095227..2095697) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(2095698..2095774) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2095698 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2095749..2095768) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2095774) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2095776..2095882) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2095783..2095790) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2095883..2096221) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(2095883..2096221) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(2096218..2097456) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(2096218..2097456) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 2096380..2096381 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2096391 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2096446 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2097481..2097499) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2097490) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(2097516..2097521) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2097561..2097564 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2097579..2097598 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2097588 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 2097622..2097828 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 2097622..2097828 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 2098311..2098314 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2098329..2098348 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2098345 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 2098377..2099609 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 2098377..2099609 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 2099456..2099818 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 2099456..2099818 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(2099635..2099814) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2099668) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2099815..2100201) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(2099815..2100201) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(2100205..2101164) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(2100205..2101164) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(2101165..2101235) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2101236..2102582) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(2101236..2102582) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(2102583..2102657) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2102658..2103437) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(2102658..2103437) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(2103443..2104402) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(2103443..2104402) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2104424..2104443) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2104443) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2104458..2104465) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2104499..2104506 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2104520..2104806 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2104520 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2104522..2104541 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2104536..2104781 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2104536..2104781 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2104807..2105643 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2104807..2105643 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2105641 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2105684..2107327) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2105684..2107327) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2105696) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2107345..2107351 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2107358 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2107365..2107376 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2107383..2107402) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2107388) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2107434..2107441 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2107455..2107474 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2107457 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2107499..2108515 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2107499..2108515 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2108502 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2108564..2108573 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2108586..2108601 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2108590 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2108625..2109386 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2108625..2109386 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2109294 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2109382 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2109414..2109614) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2109430..2109555) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2109430..2109555) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2109457) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2109548..2109580) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2109548..2109580) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2109608..2109627) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2109614) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2109640..2109647) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2109662..2110585) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2109662..2110585) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2110611..2110630) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2110624) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2110644..2110649) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2110723..2110730 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2110744..2110763 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2110746..2110811 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2110746 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2110812..2112281 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2110812..2112281 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2112264 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2112289..2112328 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2112301,2112304) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2112309,2112310) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2112321,2112322) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2112330 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2112404..2113813) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2112404..2113813) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2112421) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2112494) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2113877..2113895) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2113879) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2113923..2115167) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2113923..2115167) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2115168..2115442) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2115188..2115195 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2115209..2115228 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2115209 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2115240..2115527 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2115240..2115527 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2115424..2115443) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2115444) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2115459..2115462) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2115558..2116385 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2115558..2116385 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2116202 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2116378 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2116390..2117310) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2116433) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2116503..2116509 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2116523..2116541 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2116532 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2116565..2117293 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2116565..2117293 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2117334..2118449) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2117334..2118449) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2117355) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2118467..2119990) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2118467..2119990) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2119573..2119592) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119595) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119607..2119611) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2119983..2120405) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2119983..2120405) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2120434..2120441 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2120455..2120474 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2120469..2120622 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2120469 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2120579 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2120607..2121137) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2120607..2121137) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2120624..2121259 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2121154..2121165) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2121161) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2121180..2121186) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2121189..2122157) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2121189..2122157) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2121205) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2122228..2122950) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2122228..2122950) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2122239) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2122943..2123602) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2122943..2123602) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2123603..2123682) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2123683..2124450) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2123683..2124450) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2124500..2124519) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2124515) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2124534..2124541) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2124718..2125155) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2124718..2125155) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2124727) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2125179..2125198) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2125200) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2125213..2125220) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2125253..2125259 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2125272 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2125274..2125292 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2125316..2126209 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2125316..2126209 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2126242..2126249 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2126265..2126284 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2126273 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2126310..2127479 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2126310..2127479 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2127462 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2127552..2128388 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2127552..2128388 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2128386 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2128450) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2128450..2129724) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2128450..2129724) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2129747..2130730) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2129747..2130730) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2130744..2131736) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2130744..2131736) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2131758..2133182) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2131758..2133182) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2133203..2134294) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2133203..2134294) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2134313..2135407) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2134313..2135407) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2135419..2136318) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2135419..2136318) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2136354..2136373) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2136359) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2136361..2136442) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2136443..2138521) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2136443..2138521) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2138581..2138600) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2138598) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2138608..2138615 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2138617..2138620) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2138629..2138648 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2138636 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2138674..2138910 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2138674..2138910 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2138901 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2138952..2139857) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2138952..2139857) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2138955) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2139875..2141293) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2139875..2141293) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2140170..2140189) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2140187) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2141308..2142426) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2141308..2142426) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2142460..2143599) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2142460..2143599) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2143627..2144490) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2143627..2144490) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2144515..2145696) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2144515..2145696) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2145276) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2145383..2145389) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2145386) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2145610..2145710) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2145650) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2145743..2145761) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2145761) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2145777..2145782) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2145823..2146554) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2145823..2146554) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2145830) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2146577..2146596) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146588) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146611..2146614) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2146633..2147253) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2146633..2147253) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2147268..2147561) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2147268..2147561) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2147581..2147600) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147587) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2147615..2147622) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2147817..2147824 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2147838..2147857 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2147855..2148060 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2147855 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2147869..2148021 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2147869..2148021 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2148029..2148036 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2148051..2148070 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2148062 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2148094..2149212 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2148094..2149212 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2149197 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2149239..2149409) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2149282) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2149393..2149408) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149409) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2149411..2149539) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2149420..2149429) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2149538..2149557) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149561) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2149571..2149579) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2149671) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2149677..2150480) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2149677..2150480) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2150523..2150541) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2150529) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2150531..2150683) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2150552..2150560) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2150679..2150698) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2150691) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2150710..2150717) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2150756..2152036) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" /label="spoIVB CDS" gene complement(2150756..2152036) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /label="spoIVB gene" downshifts complement(2150771) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2152097..2152108) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2152111) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2152123..2152129) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2152211..2153941) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2152211..2153941) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2152226) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2153978..2154427) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2153978..2154427) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2154428..2154513) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2154525..2155370) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2154525..2155370) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2154558) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2155367..2157268) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2155367..2157268) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2156476..2156482 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2156497..2156508 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2156505 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2157269..2157397) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2157392..2157411) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2157397) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2157426..2157432) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2157443..2158333) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2157443..2158333) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2158323..2158577) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2158323..2158577) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2158574..2159920) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2158574..2159920) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2159921..2160057) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2160058..2160909) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2160058..2160909) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2160921..2161316) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2160921..2161316) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2161359..2161378) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2161378) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2161380..2161542) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2161580..2161987) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2161580..2161987) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2161587) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2162008..2163360) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2162008..2163360) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2162889..2162908) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2162896) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2162923..2162929) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2163372..2163851) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2163372..2163851) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2163910..2163929) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2163921) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2163943..2163950) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2164007..2164663) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2164007..2164663) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2164014) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2164664..2165353) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2164664..2165353) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2165346..2165966) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2165346..2165966) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2165672..2165690) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2165690) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2165706..2165711) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2165980..2167179) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2165980..2167179) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2167198..2167599) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2167198..2167599) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2167606..2167812) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2167606..2167812) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2167835..2168350) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2167835..2168350) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2168344..2169267) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2168344..2169267) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2169268..2169342) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2169343..2169624) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2169343..2169624) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2169644..2169662) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2169667) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2169678..2169683) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2169769..2170326) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2169769..2170326) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2169781) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2170351..2171412) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2170351..2171412) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2171409..2171855) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2171409..2171855) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2171904..2171923) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2171920) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2171936..2171943) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2171942..2172478) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2171942..2172478) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2172491..2172502) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2172500) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2172516..2172522) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2172548..2172554 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2172567 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2172569..2172587 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2172624..2172627 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2172642..2172661 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2172653 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2172705..2173661 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2172705..2173661 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2173701..2174096 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2173701..2174096 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2173979..2174079 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2174039 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2174082 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2174093..2174968) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2174093..2174968) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2174995..2175013) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2175012) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2175029..2175034) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2175094..2175522) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2175094..2175522) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2175121) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2175557..2175576) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2175565) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2175592..2175596) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2175622..2176458) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2175622..2176458) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2176482..2176501) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2176493) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2176495..2177039) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2176515..2176522) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2176539..2176544 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2176558..2176577 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2176558 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2176569..2176648 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2176649..2177029 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2176649..2177029 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2176965 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2177009 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2177064..2178530) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2177064..2178530) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2177084) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2178523..2179869) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2178523..2179869) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2179899..2180987) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2179899..2180987) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2181061..2181260) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2181061..2181260) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2181111) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2181261..2181331) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2181264..2181269 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2181285..2181303 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2181289 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2181299..2181428 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2181317..2181336) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2181331) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2181350..2181357) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2181429..2183102 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2181429..2183102 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2183123..2183917 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2183123..2183917 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2183453..2183454 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2183459 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2183941..2183944 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2183960..2183979 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2183961..2184099 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2183961 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2184100..2184273 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2184100..2184273 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2184258..2184262 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2184275..2184294 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2184275 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2184307..2184642 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2184307..2184642 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2184619 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2184709 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2184735..2185520) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" /label="tasA CDS" gene complement(2184735..2185520) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /label="tasA gene" downshifts complement(2184741) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2185573..2185590) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2185577) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2185584..2186156) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" /label="sipW CDS" gene complement(2185584..2186156) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /label="sipW gene" CDS complement(2186140..2186901) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" /label="tapA CDS" gene complement(2186140..2186901) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /label="tapA gene" promotor_-10 complement(2186961..2186980) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2186979) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="upshifts" promotor_-35 complement(2186994..2187001) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2187123..2187129 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2187130 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2187143..2187154 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2187173..2187499 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2187173..2187499 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2187316..2187540) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2187359) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2187481 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2187541..2187720) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2187541..2187720) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2187739..2187757) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2187754) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2187772..2187778) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2187791..2188165) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2187791..2188165) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2188166..2188549) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2188166..2188549) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2188575..2188922) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2188575..2188922) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2188906..2189337) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2188906..2189337) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2189327..2189623) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2189327..2189623) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2189637..2190608) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2189637..2190608) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2190661..2191731) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2190661..2191731) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2191749..2191768) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2191765) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2191782..2191789) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2191914..2192142) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2191955) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2192143..2193096) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2192143..2193096) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2193120..2193139) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2193141) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2193153..2193159) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2193179..2193185 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2193200..2193218 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2193218 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2193239..2194567 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2193239..2194567 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2194568..2195542 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2194620..2195456) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2194620..2195456) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2195457..2195641) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2195543..2195613 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2195543..2195613 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2195680..2196060) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2195680..2196060) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2195686) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2196089..2196107) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2196108) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2196122..2196128) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2196147..2196152 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2196168..2196186 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2196177 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2196227..2196234 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2196249 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2196250..2196269 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2196292..2196537 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2196292..2196537 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2196434 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2196523 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2196568..2197323 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2196577..2197212) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2196577..2197212) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2196602) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2197234..2197253) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2197251) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2197267..2197274) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2197291..2197298 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2197313..2197332 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2197325 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2197345) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2197347..2197361) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2197369..2197373) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2197369..2197542 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2197369..2197542 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2197530 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2197574..2197888) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2197574..2197888) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2197575..2198642 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2197588) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2197891..2198952) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2197891..2198952) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2199014..2200144) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2199014..2200144) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2200152..2200170) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2200184) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2200186..2200191) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2200227..2202143) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2200227..2202143) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2200254) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2201259..2201265 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2201278..2202307 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2201278 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2201281..2201299 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2202144..2202210) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2202204..2202223) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2202210) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2202238..2202245) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2202260..2203225) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2202260..2203225) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2203236..2203451) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2203236..2203451) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2203452..2203560) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2203561..2205084) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2203561..2205084) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2205102..2205121) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2205115) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2205136..2205143) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2205174..2205347) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2205174..2205347) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2205201) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2205363..2205374) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2205375) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2205388..2205394) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2205414..2205977) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2205414..2205977) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2205978..2206061) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2206062..2206211) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2206062..2206211) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2206108) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2206248..2206267) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2206258) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2206283..2206286) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2206295..2207374) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2206295..2207374) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2207371..2207841) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2207371..2207841) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2207786..2207794 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2207808..2207816 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2207809..2207982 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2207810 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2207877..2207896) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2207889) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2207908..2207915) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2207954..2207958 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2207974..2207993 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2207984 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2208021..2208374 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2208021..2208374 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2208371..2208835 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2208371..2208835 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2208821 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2208864..2209646) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2208864..2209646) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2208875) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2209657..2210466) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2209657..2210466) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2210487..2211371) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2210487..2211371) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2211371..2212300) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2211371..2212300) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2212369..2213271) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2212369..2213271) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2213326) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2213334..2213350) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2213361..2213363) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2213380,2213382) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2213426..2215576) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2213426..2215576) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2213436) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2214170..2214188) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214178) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2214204..2214210) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2214865..2214884) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214882) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2214898..2214907) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2215626..2215645) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2215631) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2215661..2215665) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2215690..2216982) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2215690..2216982) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2217005..2217016) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217016) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2217030..2217036) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2217089..2217697) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2217089..2217697) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2217104) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2217749..2217768) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217760) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2217762..2217830) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2217783..2217790) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2217821..2217839) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217830) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2217854..2217860) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2217876..2218358) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2217876..2218358) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2218359..2218651) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2218401..2218407 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2218422..2218441 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2218435 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2218468..2219235 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2218468..2219235 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2218649..2218667) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2218651) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2218653..2219589) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2218681..2218687) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2219236..2219666 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2219623 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2219634) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2219651..2220079) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2219651..2220079) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2220075..2220079 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2220089..2220103 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2220098 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2220102..2220121) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2220125) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2220136..2220143) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2220294..2220299 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2220315..2220333 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2220327 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2220356..2220655 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2220356..2220655 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2220668..2220675 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2220690..2220709 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2220701..2220777 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2220701 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2220778..2221911 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2220778..2221911 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2221892 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2221937..2222326) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2221937..2222326) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2221963) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2222357..2222368) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2222361) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2222382..2222388) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2222401..2222408 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2222419..2222438 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2222420 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2222459..2223040 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2222459..2223040 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2223038 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2223083..2223691 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2223083..2223520) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2223083..2223520) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2223087) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2223521..2223615) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2223611..2223630) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223615) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2223645..2223652) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2223658..2224539) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2223658..2224539) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2224535..2224540 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2224556..2224574 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2224572 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2224577..2224596) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2224583) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2224585..2224912) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2224601..2224610 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2224617 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2224623..2224642 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2224655..2224909 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2224655..2224909 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2224896 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2224936..2225829) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2224936..2225829) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2224941..2225742 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2224957) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2225839..2227155) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2225839..2227155) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2227191..2227210) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2227202) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2227226..2227230) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2227259..2227268 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2227280 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2227282..2227301 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2227324..2228067 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2227324..2228067 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2228049 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2228071..2228078 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2228092..2228111 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2228094..2228189 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2228094 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2228190..2229134 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2228190..2229134 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2229105 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2229157..2230278) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2229157..2230278) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2229182) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2230271..2230921) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2230271..2230921) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2230922..2231030) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2231018..2231037) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231030) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2231032..2231145) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2231053..2231057) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2231178..2231540) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2231178..2231540) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2231190) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2231536..2231540 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2231548..2231562 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2231569 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2231577..2231596) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231579) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2231581..2231702) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2231608..2231615) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2231691..2231710) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2231699..2231718 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231702) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2231704..2231843) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2231705..2231809 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2231705 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2231724..2231730) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2231773..2231780 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2231794..2231813 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2231811..2233960 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2231811 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2231869..2232984) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2231869..2232984) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2231888) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2232985..2233182) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2233183..2234994) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2233183..2234994) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2234589..2234595 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2234605 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2234607..2234626 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2234634..2234930 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2234634..2234930 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2235028..2235522) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2235028..2235522) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2235495..2235513) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2235506) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2235523..2235636) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2235525..2235533) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2235531..2235536 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2235552..2235570 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2235567 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2235621..2235639) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2235636) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2235638..2235715) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2235655..2235660) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2235681..2235700) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2235715) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2235716..2235719) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2235776..2236588) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2235776..2236588) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2236614..2237252) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2236614..2237252) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2237253..2237384) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2237378..2237397) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2237385..2239424) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2237385..2239424) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2237387) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2237412..2237419) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2237431) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2237497) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2239417..2240304) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2239417..2240304) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2240387..2240561) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2240387..2240561) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2240421) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2240536..2240541 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2240557..2240575 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2240565..2240584) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2240567..2241979 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2240567 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2240577) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2240599..2240606) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2240601..2241368) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2240601..2241368) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2241405..2241548) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2241405..2241548) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2241549..2241695) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2241696..2242601) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2241696..2242601) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2242582..2242992) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2242582..2242992) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2243030..2243049) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2243041) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2243043..2243110) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2243064..2243067) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2243111..2243482) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2243111..2243482) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2243463..2243936) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2243463..2243936) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2243937..2246072) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2243937..2246072) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2245916..2245921 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2245936 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2245937..2245955 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2246151..2247110) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2246151..2247110) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2246166) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2247107..2248303) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2247107..2248303) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2247174..2247193) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2247179) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2247207..2247214) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2247254..2247272) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2247266) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2247287..2247293) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2247481) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2247495..2247506) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2247521..2247527) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2248322..2248603) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2248322..2248603) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2248660..2249079) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2248660..2249079) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2248674) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2249104..2250099) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2249104..2250099) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2250121..2251434) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2250121..2251434) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2251470..2251485) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2251487) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2251498..2251507) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2251565..2252011) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2251565..2252011) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2251578) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2251776) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2252026..2252199) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2252026..2252199) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2252135..2252139 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2252140 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2252260..2252279) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2252275) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2252293..2252300) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2252318..2252323 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2252338 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2252339..2252357 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2252372..2253295 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2252372..2253295 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2253332..2254687) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2253332..2254687) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2253338) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2254687..2255457) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2254687..2255457) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2255480..2256415) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2255480..2256415) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2256440..2257567) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2256440..2257567) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2257484..2257487 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2257495 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2257568..2257745) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2257607..2257697 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2257607..2257697 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2257767..2259602) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2257767..2259602) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2257790) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2259626..2260189) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2259626..2260189) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2260190..2260260) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2260261..2261292) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2260261..2261292) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2261333..2261352) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2261346) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2261367..2261374) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2261373..2262512) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2261373..2262512) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2262385..2262396) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2262389) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2262410..2262416) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2262565..2264403) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2262565..2264403) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2262587) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2264438..2264457) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2264455) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2264473..2264477) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2264537..2264875) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2264537..2264875) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2264543) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2264892..2266097) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2264892..2266097) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2266117..2266135) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2266129) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2266151..2266156) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2266160..2267266) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2266160..2267266) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2267294..2267305) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267301) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2267320..2267326) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2267365..2267368 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2267381 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2267384..2267403 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2267395..2267469 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2267470..2267736 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2267470..2267736 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2267725 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2267751..2268794) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2267751..2268794) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2267796) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2268823..2268842) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2268834..2268983) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2268834..2268983) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2268835) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2268856..2268860) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2268858..2269197) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2268901) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2268970..2268976 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2268990..2269009 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2268991 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2269024..2269158 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2269024..2269158 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2269152 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2269198..2271528) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2269198..2271528) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2269215..2269234) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269231) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2269248..2269257) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2271532..2272101) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2271532..2272101) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2272128..2272147) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2272138) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2272162..2272169) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2272168..2272785) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2272168..2272785) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2272806..2272811 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2272823 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2272827..2272845 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2272846..2272860) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2272848) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2272850..2273697) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2272869..2272873) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2272869..2273690 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2272869..2273690 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2273685..2273704) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2273691..2273771 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2273698) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2273718..2273725) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2273731 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2273756..2274499) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2273756..2274499) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2273786) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2274496..2274852) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2274496..2274852) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2274870..2275430) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2274870..2275430) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2275420..2275989) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2275420..2275989) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2276001..2276291) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2276001..2276291) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2276285..2277127) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2276285..2277127) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2277119 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2277145..2278245) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2277145..2278245) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2278249..2278767) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2278249..2278767) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2278677..2278694) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2278691) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2278710..2278713) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2278768..2279329) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2278801) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2278992..2278999 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2279010..2279110 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2279010..2279029 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2279010 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2279060..2279318) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2279060..2279318) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2279111..2279269 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2279111..2279269 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2279270..2279516 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2279317..2279336) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279328) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2279352..2279356) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2279380..2279527) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2279417) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2279473 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2279518..2280571 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2279522..2279541) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279527) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2279554..2279563) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2279575..2280306) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" /label="yqeF CDS" gene complement(2279575..2280306) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /label="yqeF gene" promotor_-10 complement(2280325..2280344) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2280341) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2280343..2280451) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2280358..2280364) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2280452..2280470) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2280473) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2280485..2280490) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2280558..2281310) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" /label="cwlH CDS" gene complement(2280558..2281310) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /label="cwlH gene" downshifts complement(2280561) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2280689..2280695 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2280709..2280727 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2280716 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2281320..2281339) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2281339) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2281353..2281361) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2281405..2281412 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2281427..2281446 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2281431..2281496 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2281431 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="upshifts" CDS 2281497..2282123 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" /label="yqeD CDS" gene 2281497..2282123 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /label="yqeD gene" downshifts 2282091 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2282142..2283035) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" /label="yqeC CDS" gene complement(2282142..2283035) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /label="yqeC gene" downshifts complement(2282167) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" /label="downshifts" promotor_-35 2283218..2283224 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2283236..2283255 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2283236 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="upshifts" CDS 2283287..2284009 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" /label="yqeB CDS" gene 2283287..2284009 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /label="yqeB gene" CDS complement(2284042..2284452) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" /label="nucB CDS" gene complement(2284042..2284452) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /label="nucB gene" downshifts complement(2284067) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2284472..2284490) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2284474) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2284506..2284511) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2284575..2284583 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2284596 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2284597..2284616 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2284648..2285118 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" /label="sigKn CDS" gene 2284648..2285118 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo /label="sigKn gene" downshifts 2284838 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 2284970 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2285026..2286528) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" /label="spoIVCA CDS" gene complement(2285026..2286528) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /label="spoIVCA gene" downshifts complement(2285042) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2286635..2286653) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2286653) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2286655..2286956) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2286670..2286675) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2286977..2287396) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" /label="arsC CDS" gene complement(2286977..2287396) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /label="arsC gene" downshifts complement(2287001) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" /label="downshifts" CDS complement(2287408..>2287536) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2287408..>2287536) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2287532,2287539) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2287533..2287538 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2287534..2287920 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2287534..2287920 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2287887..2287905) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2287902..2288318 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" /label="sigKc CDS" gene 2287902..2288318 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo /label="sigKc gene" misc_feature 2287907..2287921 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2287915) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 2287926 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="upshifts" downshifts 2288302 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS 2288318..2288434 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" /label="hypothetical protein CDS" gene 2288318..2288434 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /label="gene" S_feature 2288347..2289681 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2288465) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(2288543..2288707) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" /label="yrkS CDS" gene complement(2288543..2288707) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /label="yrkS gene" promotor_-10 complement(2288637..2288656) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288663) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2288671..2288678) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2288841) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" CDS complement(2289252..2289668) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2289252..2289668) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2289714..2291012) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2289714..2291012) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2290999..2291694) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2290999..2291694) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2291760..2291777) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2291769) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2291855..2291861 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2291868..2291886 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2291883 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2291962..2293179 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2291962..2293179 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2292421..2292428 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2292443..2292462 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2292459 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2293098..2293346 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2293098..2293346 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2293275..2294322) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2293691..2294248 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2293691..2294248 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2294249..2294371 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2294324..2294738) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2294367) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2294739..2295263) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2294739..2295263) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2295111..2295118 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2295129..2295148 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2295143 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2295264..2295351) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2295346..2295365) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2295351) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2295353..2295506) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2295380..2295387) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2295507..2295983) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390525.2" /db_xref="EnsemblGenomes-Gn:BSU26480" /db_xref="EnsemblGenomes-Tr:CAB14589" /db_xref="GOA:P54438" /db_xref="InterPro:IPR025671" /db_xref="SubtiList:BG11777" /db_xref="UniProtKB/Swiss-Prot:P54438" /translation="MVYFVAFFCFAITLHNIEEAIWLPEWSQQSSKFQKPVTSNEFHF AVIVITMLAYLSAFGFLYMPESDIAKWIFIGFLGSMVINAIFPHLIATVVMKKYAPGL LTGLLLNIPVNSLVIYQMFLKNLIVWKELIISTLVVGIILLALIPLLFKVGDKVSP*" /label="yrkK CDS" gene complement(2295507..2295983) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /label="yrkK gene" promotor_-10 complement(2296019..2296038) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2296033) /Source="Nicolas_upshifts" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2296035..2296565) /Source="Nicolas_S_feature" /locus_tag="new_2709471_2710001_c" /HighExp="Diami, dia15, S8, G180, Etha, G135, S6, S0, G150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S990" promotor_-35 complement(2296052..2296059) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2296566..2297351) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_390526.1" /db_xref="EnsemblGenomes-Gn:BSU26490" /db_xref="EnsemblGenomes-Tr:CAB14590" /db_xref="GOA:P54437" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG11776" /db_xref="UniProtKB/Swiss-Prot:P54437" /translation="MDIAFITTLFIIGFIGAFISGMIGIGGAVINYPMLLYIPSLVGV MSLTAHEVSGIGAIQVFFATLGGVWAYRKSGLINKTLIIYMGSSILLGSVLGSYFSHY ISEKGINFIYGILAIIAVILMFIPKKGQKGQEHSEDKEVIFNKWLASSLAFIIGGVSG ILGAGGAFILVPIMLSILNIPVRVTVASSLAITFLSSIGATVGKVITGQVLFVPALVL MITSLIASPIGASVGQKVNTKFLQWVLAQLIGATAIKIWLELL*" /label="yrkJ CDS" gene complement(2296566..2297351) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /label="yrkJ gene" CDS complement(2297412..2297639) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9555915; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur-carrier protein" /protein_id="NP_390527.1" /db_xref="EnsemblGenomes-Gn:BSU26500" /db_xref="EnsemblGenomes-Tr:CAB14591" /db_xref="GOA:P54436" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR036868" /db_xref="SubtiList:BG11775" /db_xref="UniProtKB/Swiss-Prot:P54436" /translation="MKSDKVLDAKGLACPMPIVRTKKAMNELESGQILEVHATDKGAK NDLTAWSKSGGHDLLEQTDEGDILKFWIQKG*" /label="yrkI CDS" gene complement(2297412..2297639) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /label="yrkI gene" downshifts complement(2297436) /Source="Nicolas_upshifts" /id="D1361" /incds=0 /nref=4 /ntot=22 /MaxReadThrough="5.31659" /MaxDrop="3.95633" /score="-3.35079978" /energy="-23.7" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=3085 /isTUend="FALSE" /label="downshifts" CDS complement(2297673..2298806) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase / hydrolase" /protein_id="NP_390528.2" /db_xref="EnsemblGenomes-Gn:BSU26510" /db_xref="EnsemblGenomes-Tr:CAB14592" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036866" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11774" /db_xref="UniProtKB/Swiss-Prot:P54435" /translation="MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDF DHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGM KAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFA KGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDII IGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLR KTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHL VTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR*" /label="yrkH CDS" gene complement(2297673..2298806) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /label="yrkH gene" misc_feature complement(2298508..2298523) /Source="Nicolas_upshift_promotors" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2298519) /Source="Nicolas_upshifts" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2298807..2299140) /Source="Nicolas_S_feature" /locus_tag="new_2712243_2712576_c" /HighExp="Diami, dia15, Sw, BC, S0, G180, dia5, G135, M9-stat, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99950300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S991" CDS complement(2299141..2299698) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhodanese-related sulfur transferase" /protein_id="NP_390530.1" /db_xref="EnsemblGenomes-Gn:BSU26530" /db_xref="EnsemblGenomes-Tr:CAB14594" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036868" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11772" /db_xref="UniProtKB/Swiss-Prot:P54433" /translation="MMKATIVLDAKGLACPMPIVKTKKRMKDLKAGEVLEIHATDKGS TADLEAWAKSTGHEYLGTEAEGEILRHFLRKGGEHSSENASSIPEISLEAFKQKVDSD ESLNILDVREIEEYEKAHIPGVVHIPLGEVEKRANELNENDEIYIICHSGRRSEMAAR TMKKQGFKKVINVVPGMRDWTGKTE*" /label="yrkF CDS" gene complement(2299141..2299698) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /label="yrkF gene" S_feature complement(2299699..2299883) /Source="Nicolas_S_feature" /locus_tag="new_2713135_2713319_c" /HighExp="Diami, dia15, Sw, BC, S8, dia5, G180, S7, S0, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12629799999999999" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S992" CDS complement(2299884..2300366) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein involved in sulfur metabolism (DsrE-like)" /protein_id="NP_390531.1" /db_xref="EnsemblGenomes-Gn:BSU26540" /db_xref="EnsemblGenomes-Tr:CAB14595" /db_xref="InterPro:IPR027396" /db_xref="InterPro:IPR032836" /db_xref="SubtiList:BG11771" /db_xref="UniProtKB/Swiss-Prot:P54432" /translation="MTEQTKRTTIVLFSGDYDKAMAAYIIANGAAAYDHEVTIFHTFW GFNALRKEELIPVKKGFLEKMFGKMMPRGADKMGLSKMNFAGMGPKMIKNVMKKHNVL TLPQLIEMAQEQGVKLVACTMTMDLLGLQEKELLDDIDYAGVAAYLADAEEGSVNLFI *" /label="yrkE CDS" gene complement(2299884..2300366) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /label="yrkE gene" S_feature complement(2300367..2300475) /Source="Nicolas_S_feature" /locus_tag="new_2713803_2713911_c" /HighExp="Diami, dia15, Sw, BC, dia5, S8, G180, S6, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S993" CDS complement(2300513..2300704) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21339296; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative metal-sensitive transcriptional regulator involved in sulfur metabolism" /protein_id="NP_390532.1" /db_xref="EnsemblGenomes-Gn:BSU26550" /db_xref="EnsemblGenomes-Tr:CAB14596" /db_xref="GOA:P54431" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG11770" /db_xref="UniProtKB/Swiss-Prot:P54431" /translation="MMEQGKDCREVVTQLAASRNAIDRAMGLIVSTNLEHCVRESLEK GEDTQNLVKEAVDLLVKSR*" /label="yrkD CDS" gene complement(2300513..2300704) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /label="yrkD gene" downshifts complement(2300520) /Source="Nicolas_upshifts" /id="D1362" /incds=0 /nref=153 /ntot=252 /MaxReadThrough="8.17686" /MaxDrop="5.42995" /score="-6.39526496" /energy="-7.9" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2300705..2300794) /Source="Nicolas_S_feature" /locus_tag="new_2714141_2714230_c" /HighExp="Diami, dia15, S6, S7, S8, Etha, dia5, S5, BC, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="1, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S994" CDS complement(2300795..2301112) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="PSEUDO:CAX52666.1" /translation="MIIIATYRRYYPITGISCIHKDKLEAMDITILDIRHYNDVANFS DNIILNIPYAYLKRFYLEIPRDKIHIIARDRVELNLGVRFLKRKGIHVNSYELATCKC KNK*" /label="yrzM CDS" gene complement(2300795..2301112) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /pseudo /label="yrzM gene" promotor_-10 complement(2300901..2300920) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2300917) /Source="Nicolas_upshifts" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2300933..2300939) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2301154..2301369) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52667.1" /translation="MINKADLKLNRLIALFEFLLAELALSNVSIFSIRGYRNESISSK KVTFTLDYIPMGVYYCFVNKQRVNKVV*" /label="yrzN CDS" gene complement(2301154..2301369) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /pseudo /label="yrzN gene" promotor_-10 complement(2301182..2301201) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301196) /Source="Nicolas_upshifts" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2301216..2301223) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2301370..2301496) /Source="Nicolas_S_feature" /locus_tag="new_2714806_2714932_c" /HighExp="S6, S7, S8, S5, BT, B36, G/S, BC, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.114547" /TUshortSig="SigK, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S995" CDS complement(2301497..2302057) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_390533.1" /db_xref="EnsemblGenomes-Gn:BSU26560" /db_xref="EnsemblGenomes-Tr:CAB14597" /db_xref="GOA:P54430" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG11769" /db_xref="UniProtKB/Swiss-Prot:P54430" /translation="MYYNPFSPQCYYYVTVPMYNDGRSVYWTIPNEMEKVHRGADLRS SYEDRNLLLKDYGPKPFVVNINRATKQNNTFRTALWTGKHFQVTLMSLGIGEDIGLEI HPNVDQFLRIEQGRGIVKMGKSKDHLNFQRNVYDDSAIVVPAGTWHNVINTGNTPLKL YSIYAPPNHPFGTVHETKADAVAAED*" /label="yrkC CDS" gene complement(2301497..2302057) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /label="yrkC gene" CDS complement(2302074..2302250) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513984.1" /translation="MLTKASEIQHLENDYKVGDKLFIHESNGDRTFIFVFNMSFLDLA HSLNKCIGYYHKNL*" /label="hypothetical protein CDS" gene complement(2302074..2302250) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /label="gene" promotor_-10 complement(2302084..2302103) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2302095) /Source="Nicolas_upshifts" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2302097..2302282) /Source="Nicolas_S_feature" /locus_tag="new_2715533_2715718_c" /HighExp="BC, Sw, S3, dia15, Etha, S4, S5, H2O2, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49093999999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S996" promotor_-35 complement(2302116..2302125) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2302283..2302429) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390534.1" /db_xref="EnsemblGenomes-Gn:BSU26570" /db_xref="EnsemblGenomes-Tr:CAB14598" /db_xref="SubtiList:BG11768" /db_xref="UniProtKB/Swiss-Prot:P54429" /translation="MLLKNWPSRRIQRDKSKRAGIGGTNNRIPYTLLLCYVNVQKPFR IVDL*" /label="yrkB CDS" gene complement(2302283..2302429) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /label="yrkB gene" CDS complement(2302599..2303420) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7608059, 9083003, 10200972, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7608059, 9083003, 10200972, 21954605; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (polyamine metabolism)" /protein_id="NP_390535.1" /db_xref="EnsemblGenomes-Gn:BSU26580" /db_xref="EnsemblGenomes-Tr:CAB14599" /db_xref="GOA:P39842" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="SubtiList:BG10904" /db_xref="UniProtKB/Swiss-Prot:P39842" /translation="MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGY RYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELK QLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHE VQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYE IGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV*" /label="bltR CDS" gene complement(2302599..2303420) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /label="bltR gene" promotor_-35 2303428..2303435 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2303430..2303449) /Source="Nicolas_upshift_promotors" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2303447) /Source="Nicolas_upshifts" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2303449..2305453) /Source="Nicolas_S_feature" /locus_tag="new_2716885_2718889_c" /HighExp="BC, Sw, Salt, Mal, T4.0H, M9-stat, T3.30H, G180, G135, MG 5" /AntisenseName="blt" /AntisenseCor="0.56943492854420497" /AntisenseRegPval="-23.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S997" promotor_-10 2303451..2303470 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2303459 /Source="Nicolas_upshifts" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="upshifts" CDS 2303537..2304739 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /function="16.1: Circulate" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (promiscuous, acetylated polyamines efflux)" /protein_id="NP_390536.1" /db_xref="EnsemblGenomes-Gn:BSU26590" /db_xref="EnsemblGenomes-Tr:CAB14600" /db_xref="GOA:P39843" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR004734" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10905" /db_xref="UniProtKB/Swiss-Prot:P39843" /translation="MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSG STMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFY FSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF GIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYF IAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLV NKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMA GNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEK KNDAAALN*" /label="blt CDS" gene 2303537..2304739 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /label="blt gene" CDS 2304908..2305366 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /EC_number="2.3.1.57" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermine/spermidine acetyltransferase" /protein_id="NP_390537.1" /db_xref="EnsemblGenomes-Gn:BSU26600" /db_xref="EnsemblGenomes-Tr:CAB14601" /db_xref="GOA:P39909" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027455" /db_xref="SubtiList:BG10906" /db_xref="UniProtKB/Swiss-Prot:P39909" /translation="MSINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHY YKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRVWLDRFFIDERYQGKGLGKKMLKALI QHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL*" /label="bltD CDS" gene 2304908..2305366 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /label="bltD gene" downshifts complement(2305498) /Source="Nicolas_upshifts" /id="D1363" /incds=0 /nref=77 /ntot=211 /MaxReadThrough="5.09534" /MaxDrop="4.8114" /score="-0.00168005652" /energy="-10.7" /TU="U2049" /idTUdmin="U2051" /TUdmin=3845 /isTUend="FALSE" /label="downshifts" CDS complement(2305523..2306827) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative membrane associated protein" /protein_id="NP_390538.1" /db_xref="EnsemblGenomes-Gn:BSU26610" /db_xref="EnsemblGenomes-Tr:CAB14602" /db_xref="GOA:P54428" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11767" /db_xref="UniProtKB/Swiss-Prot:P54428" /translation="MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKG AISAKKVITHLDEYLSACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVL ILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKE IMIPRREIVAISSEDSYETIVKIIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDT DQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVDEYGGTSGLVTAED ILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGG WFMTQQIDAAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE*" /label="yrkA CDS" gene complement(2305523..2306827) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /label="yrkA gene" S_feature complement(2306828..2306907) /Source="Nicolas_S_feature" /locus_tag="new_2720264_2720343_c" /HighExp="BC, Sw, MG 15, Mal, Salt, MG 25, MG-0.2, MG 45, MG 5, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S998" promotor_-10 complement(2306893..2306912) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2306907) /Source="Nicolas_upshifts" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2306927..2306934) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2307090..2307233) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097765.1" /db_xref="EnsemblGenomes-Gn:BSU26619" /db_xref="EnsemblGenomes-Tr:CAX52668" /db_xref="InterPro:IPR025417" /db_xref="UniProtKB/Swiss-Prot:C0H458" /translation="MFEGLLFFISAGIVCELAAINRNGRKNIKQQAELIQILKENLYK DIK*" /label="yrzO CDS" gene complement(2307090..2307233) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /label="yrzO gene" CDS complement(2307251..2308216) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390539.1" /db_xref="EnsemblGenomes-Gn:BSU26620" /db_xref="EnsemblGenomes-Tr:CAB14603" /db_xref="GOA:O07086" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12289" /db_xref="UniProtKB/Swiss-Prot:O07086" /translation="MKKGQLFIGALTCLVASMSWGAMFPVADHALEFVDPFYFSFIRY GVVTIMLVILLLVREGKKSFHLEGKAKWIILFGVMAFTIYNVLIFLGQRLMGKSGIMT ASIAEALMPMLSIVILWGYKHVKPKKYTMISILIAFLGASMVITKGNISFFFSLGDHL FSILFIFIGVLGWVVYTMGGQIFREWSTLRYSTLTCLFGTAITGIMTAILTAQGYVSV PSIKVIAAIKYDFLFMITLPGIIALLSWNYGIKILSSINGILFINFVPITTLLIMVIK GYNITAFDIVGTLFVIIGLILNNIYQRKEDYKQVLQKEKTNLTIT*" /label="yrdR CDS" gene complement(2307251..2308216) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /label="yrdR gene" promotor_-35 2308254..2308257 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2308272..2308291 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2308299 /Source="Nicolas_upshifts" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="upshifts" CDS 2308342..2309208 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 22666466, 25437189; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390540.1" /db_xref="EnsemblGenomes-Gn:BSU26630" /db_xref="EnsemblGenomes-Tr:CAB14604" /db_xref="GOA:P71025" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12288" /db_xref="UniProtKB/Swiss-Prot:P71025" /translation="MELRDLQIFKCVAHHKSITGAAKELNYVQSNVTARIKQLENELK TPLFNRHKKGVSLSPEGRKMIEYVNKILKDVEELEQVFLDTEIPSGILKIGTVETVRI LPTIIASYYKKYPNVDLSLQAGLTEELIKKVMNHELDGAFISGPLKHSILEQYDVYTE KLTLVTSNKTFNIEDFSTTPILVFNQGCGYRSRLEQWLKDEGVLPNRMMEFNILETIL NSVALGLGITVVPESAVMHLAVQGKVYCHPLPEKDSCISTIFIRHKDAYLTNSMRSLL KTIVEHKNMSMA*" /label="czcR CDS" gene 2308342..2309208 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /label="czcR gene" S_feature 2309209..2309309 /Source="Nicolas_S_feature" /locus_tag="new_2722645_2722745" /HighExp="HiTm, dia15, LBGstat, LPhT, T0.30H, Diami, Paraq, dia5, H2O2, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.905" /TUlongSig="NA" /TUlongPSig="NA" /label="S999" downshifts 2309267 /Source="Nicolas_upshifts" /id="D1364" /incds=0 /nref=6 /ntot=135 /MaxReadThrough="2.57006" /MaxDrop="3.43983" /score="-6.36950065" /energy="-7" /TU="NA" /idTUdmin="U2050" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2309331..2310368) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099864, 12100555, 12527699; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_390541.1" /db_xref="EnsemblGenomes-Gn:BSU26640" /db_xref="EnsemblGenomes-Tr:CAB14605" /db_xref="GOA:O07085" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000960" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11980" /db_xref="UniProtKB/Swiss-Prot:O07085" /translation="MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRY DSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLK IKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAY GNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHAS HTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNII WATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGND AEYIVKQMNGE*" /label="yrdP CDS" gene complement(2309331..2310368) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /label="yrdP gene" downshifts complement(2309343) /Source="Nicolas_upshifts" /id="D1365" /incds=0 /nref=30 /ntot=134 /MaxReadThrough="2.50972" /MaxDrop="5.83595" /score="2.19797168" /energy="-12.5" /TU="NA" /idTUdmin="U2051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2310369..2310455) /Source="Nicolas_S_feature" /locus_tag="new_2723805_2723891_c" /HighExp="LBGtran, dia5, Gly, Diami, LBGstat, M0t45, LBGexp, Lbtran, dia0, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.907, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1000" CDS complement(2310456..2311391) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium/proton-divalent cation antiporter" /protein_id="NP_390542.1" /db_xref="EnsemblGenomes-Gn:BSU26650" /db_xref="EnsemblGenomes-Tr:CAB14606" /db_xref="GOA:O07084" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11931" /db_xref="UniProtKB/Swiss-Prot:O07084" /translation="MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDA GHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEA IERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSD IIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHK GITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH*" /label="czcD CDS" gene complement(2310456..2311391) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /label="czcD gene" promotor_-10 complement(2311426..2311445) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2311433) /Source="Nicolas_upshifts" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2311435..2311518) /Source="Nicolas_S_feature" /locus_tag="new_2724871_2724954_c" /HighExp="dia5, Gly, LBGtran, Diami, LBGstat, LBGexp, LoTm, dia0, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1001" promotor_-35 complement(2311460..2311467) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2311499..2311518) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2311518) /Source="Nicolas_upshifts" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2311532..2311539) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2311653) /Source="Nicolas_upshifts" /id="D1366" /incds=0 /nref=1 /ntot=41 /MaxReadThrough="3.75163" /MaxDrop="3.57795" /score="38.5313506" /energy="-18.1" /TU="NA" /idTUdmin="U2051" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS complement(2311678..2312067) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_390543.1" /db_xref="EnsemblGenomes-Gn:BSU26660" /db_xref="EnsemblGenomes-Tr:CAB14607" /db_xref="GOA:P94502" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG12287" /db_xref="UniProtKB/Swiss-Prot:P94502" /translation="MPLLRFDLIEGRDQSSLKKLLDVAHNVVVEAFDVPQQDRYQIVH EHPENHMIIEDTGLGFNRTKNLVVLSVTSKSRPEEKKQKFYRLLAERLESECGIASTD LIVSIVENDNADWSFGLGEAQFLTGKL*" /label="yrdN CDS" gene complement(2311678..2312067) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /label="yrdN gene" promotor_-35 2312315..2312322 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2312338..2312357 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2312347 /Source="Nicolas_upshifts" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="upshifts" CDS 2312401..2313291 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390544.2" /db_xref="EnsemblGenomes-Gn:BSU26670" /db_xref="EnsemblGenomes-Tr:CAB14608" /db_xref="GOA:P94501" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11942" /db_xref="UniProtKB/Swiss-Prot:P94501" /translation="MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQ TKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAA VWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGI LEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPA LSAFLTHMRDHFQIKRPDQS*" /label="gltR CDS" gene 2312401..2313291 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /label="gltR gene" promotor_-35 2312979..2312984 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2313000..2313018 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2313007 /Source="Nicolas_upshifts" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2313449..2313766) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390545.3" /db_xref="EnsemblGenomes-Gn:BSU26680" /db_xref="EnsemblGenomes-Tr:CAB14609" /db_xref="SubtiList:BG12286" /db_xref="UniProtKB/Swiss-Prot:P94500" /translation="MRLYTEYIPNKNKLINQQQYHSDLQDLLHQWILQLLQLDVLPLS NRKYQSSRCHPKSVGEYLIVVRAIDALGNSQPLTSRRNQVSRAMTFVQNSLNEENLHP NID*" /label="yrdK CDS" gene complement(2313449..2313766) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /label="yrdK gene" CDS complement(2313724..2315046) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8544834, 9287000, 9531631, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8544834, 9287000, 9531631, 15849754, 16850406, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="low-affinity branched-chain amino acid transporter" /protein_id="NP_390546.1" /db_xref="EnsemblGenomes-Gn:BSU26690" /db_xref="EnsemblGenomes-Tr:CAB14610" /db_xref="GOA:P94499" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG11918" /db_xref="UniProtKB/Swiss-Prot:P94499" /translation="MSKKVSASYIIIIGLMLFALFFGAGNLIFPPMLGQLAGKNVWVA NAGFLVTGVGLPLLAITAFVFSGKQNLQSLASRVHPVFGIVFTTILYLAIGPFFAIPR SGNVSFEIGVKPFLSNDASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLT FIGLLVAVALIRPIGTIQAPSKGYTSQAFFKGFQEGYLTLDALVAFVFGIIIVNALKE QGASTKKQLIVVCAKAAAIAAVLLAVMYTALSYMGASSVEELGILENGAEVLAKVSSY YFGSYGSILLGLMITVACLTTSVGLITACSSFFHELFPNISYKKIAVVLSVFSTLVAN IGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISLFDGLK AAGIKIEVVNRIFTQILPMYNIGLGWLIPAIAGGICGYILSIFRTKTS*" /label="brnQ CDS" gene complement(2313724..2315046) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /label="brnQ gene" CDS complement(2315211..2315543) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390547.1" /db_xref="EnsemblGenomes-Gn:BSU26700" /db_xref="EnsemblGenomes-Tr:CAB14611" /db_xref="GOA:O07923" /db_xref="InterPro:IPR008407" /db_xref="SubtiList:BG11916" /db_xref="UniProtKB/Swiss-Prot:O07923" /translation="MTMTMTQQMITIAMVVLGTMLTRFLPFMIFPSGKPTPKYVQYLG KVLPSAVIGLLVIYCLKDVSLLSGSHGIPELVGAAAVVLLHLWKKNMLLSIAGGTVVY MVLVQLVF*" /label="azlD CDS" gene complement(2315211..2315543) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /label="azlD gene" CDS complement(2315540..2316304) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 15849754, 16850406, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390548.1" /db_xref="EnsemblGenomes-Gn:BSU26710" /db_xref="EnsemblGenomes-Tr:CAB14612" /db_xref="GOA:O07942" /db_xref="InterPro:IPR004471" /db_xref="InterPro:IPR011606" /db_xref="SubtiList:BG11915" /db_xref="UniProtKB/Swiss-Prot:O07942" /translation="MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFL FLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNA RHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNH LYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVA SLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV*" /label="azlC CDS" gene complement(2315540..2316304) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /label="azlC gene" CDS complement(2316317..2316790) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 9287000, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 9287000, 26473603; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the azlBCD operon" /protein_id="NP_390549.1" /db_xref="EnsemblGenomes-Gn:BSU26720" /db_xref="EnsemblGenomes-Tr:CAB14613" /db_xref="GOA:O07920" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11914" /db_xref="UniProtKB/Swiss-Prot:O07920" /translation="MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKN LVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTL TGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM*" /label="azlB CDS" gene complement(2316317..2316790) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /label="azlB gene" CDS complement(2317124..2317399) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative ribonuclease inhibitor" /protein_id="NP_390550.1" /db_xref="EnsemblGenomes-Gn:BSU26730" /db_xref="EnsemblGenomes-Tr:CAB14614" /db_xref="GOA:O07938" /db_xref="InterPro:IPR000468" /db_xref="InterPro:IPR035905" /db_xref="SubtiList:BG12285" /db_xref="UniProtKB/Swiss-Prot:O07938" /translation="MRKIIIDGRDFENIEVLHDDLKDKLDFPDYYGRNLDALWDCLTG WVDLPLTLVLKNFEFSNTFLGSYADDVLEVIQEAQEELKDEFKIIIE*" /label="yrdF CDS" gene complement(2317124..2317399) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /label="yrdF gene" misc_feature complement(2317411..2317430) /Source="Nicolas_upshift_promotors" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2317417) /Source="Nicolas_upshifts" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2317485..2317670) /Source="Nicolas_S_feature" /locus_tag="new_2730921_2731106_c" /HighExp="BT, S4, S8, S3, S5, S7, S6, LoTm, B36, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S1002" CDS complement(2317671..2318903) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9778370, 12354229, 28898812" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9778370, 12354229, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450" /protein_id="NP_390551.1" /db_xref="EnsemblGenomes-Gn:BSU26740" /db_xref="EnsemblGenomes-Tr:CAB14615" /db_xref="GOA:O08469" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG11929" /db_xref="UniProtKB/Swiss-Prot:O08469" /translation="MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM KWKGNFLMRALEELPISF*" /label="cypA CDS" gene complement(2317671..2318903) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /label="cypA gene" CDS complement(2318953..2319111) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; C-terminal part of YrdD" /db_xref="PSEUDO:CAX52669.1" /translation="MEVLGVSPFYQGKSLGSKMINDCLISFISKCGDGILALIMNTDL NGSFYKSS*" /label="yrdDc CDS" gene complement(2318953..2319111) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /pseudo /label="yrdDc gene" CDS complement(2319108..2319311) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; internal part of YrdD" /db_xref="SubtiList:BG12284" /translation="MHKVLTRAYFKKHFFFVGIQNGEMVVAALLKHRDKPDIKLDRLY SSRGDNINQNGAKKFSKSLKEPA*" /label="yrdDm CDS" gene complement(2319108..2319311) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /pseudo /label="yrdDm gene" promotor_-10 complement(2319272..2319290) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2319289) /Source="Nicolas_upshifts" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2319296..2319445) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; N-terminal part of YrdD" /db_xref="SubtiList:BG14036" /translation="MFLYRQARADEVSKVAKLFHQSFNQYPFMDLLVKREKKIIHLFL KCIKY*" /label="yrdDn CDS" gene complement(2319296..2319445) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /pseudo /label="yrdDn gene" promotor_-35 complement(2319305..2319310) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2319529) /Source="Nicolas_upshifts" /id="D1367" /incds=0 /nref=140 /ntot=216 /MaxReadThrough="2.2276" /MaxDrop="4.5127" /score="5.01317133" /energy="-16.7" /TU="NA" /idTUdmin="U2057" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2319544..2320107) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390553.1" /db_xref="EnsemblGenomes-Gn:BSU26760" /db_xref="EnsemblGenomes-Tr:CAB14617" /db_xref="GOA:O07081" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12283" /db_xref="UniProtKB/Swiss-Prot:O07081" /translation="MEEKKALIIVDVQKAFDDKKWGERNNVKAEENISKILELWREKG WTVIYIQHTSDKPHSLFHPKNEGFAIKEIVKPMDEEVIITKTVNSSFIGTNLEEFLKL NEITTVVITGLTTPHCVSTTTRMSGNLGFDTYLISDATAAFGMRDQNDTYYDAATIHN ISLATLHDEFATILTTDQLINDFIKTH*" /label="yrdC CDS" gene complement(2319544..2320107) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /label="yrdC gene" downshifts 2320025 /Source="Nicolas_upshifts" /id="D1368" /incds=1 /nref=44 /ntot=194 /MaxReadThrough="1.72227" /MaxDrop="3.37915" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin="-4488" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2320137..2320156) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2320145) /Source="Nicolas_upshifts" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2320171..2320178) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2320336..2320707) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390554.1" /db_xref="EnsemblGenomes-Gn:BSU26770" /db_xref="EnsemblGenomes-Tr:CAB14618" /db_xref="GOA:O07080" /db_xref="InterPro:IPR021214" /db_xref="SubtiList:BG12282" /db_xref="UniProtKB/Swiss-Prot:O07080" /translation="MEKLNQTNLLLRFTLEIAALISLGVYAWISFNGYFKYVLTLVLP IAVMIVWSVFAVPHDPSRSGQTVIAVNGVTRLVIELLIFAMAVAALYFSYLKPVSIVF LCLIILHYIISAERIKWLLNQ*" /label="yrdB CDS" gene complement(2320336..2320707) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /label="yrdB gene" S_feature complement(2320708..2320937) /Source="Nicolas_S_feature" /locus_tag="new_2734144_2734373_c" /HighExp="BMM, GM 120, GM 90, SMM, MG 150, GM 60, MG 120, M9-tran, Glu, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48162700000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1003" promotor_-10 complement(2320919..2320938) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-10" upshifts complement(2320935) /Source="Nicolas_upshifts" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="upshifts" promotor_-35 complement(2320952..2320959) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-35" downshifts complement(2321503) /Source="Nicolas_upshifts" /id="D1369" /incds=0 /nref=174 /ntot=248 /MaxReadThrough="2.42722" /MaxDrop="5.81863" /score="7.90390368" /energy="-10.3" /TU="NA" /idTUdmin="U2059" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2321517..2322020) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390555.1" /db_xref="EnsemblGenomes-Gn:BSU26780" /db_xref="EnsemblGenomes-Tr:CAB14619" /db_xref="GOA:O07079" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12281" /db_xref="UniProtKB/Swiss-Prot:O07079" /translation="MFQTLDHFLKSWEFEADATQKLLNSLTDESLKQEITSQNWTLGR IAWHTVAAIGIITSNTDLTFQAPAEDYPVPTSAQFIADSYHQASNAFVQALKTQWTDH TLQERINFIGQQMPNGSLLMFLIQHQNHHRGQMTVLMRQAGLTVPGIYGPAKEEWAKF GLEAPKM*" /label="yrdA CDS" gene complement(2321517..2322020) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /label="yrdA gene" S_feature complement(2322021..2322245) /Source="Nicolas_S_feature" /locus_tag="new_2735457_2735681_c" /HighExp="Etha, Lbstat, M0t90, M40t90, LoTm, M9-stat, Gly, S2, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1004" CDS complement(2322246..2323100) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /EC_number="2.7.7.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8293959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8293959; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aminoglycoside 6-adenylyltransferase" /protein_id="NP_390556.1" /db_xref="EnsemblGenomes-Gn:BSU26790" /db_xref="EnsemblGenomes-Tr:CAB14620" /db_xref="GOA:P17585" /db_xref="InterPro:IPR007530" /db_xref="PDB:2PBE" /db_xref="SubtiList:BG11037" /db_xref="UniProtKB/Swiss-Prot:P17585" /translation="MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYD ISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDL TLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFW MVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRY LSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYT EGIYCSVK*" /label="aadK CDS" gene complement(2322246..2323100) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /label="aadK gene" S_feature complement(2323101..2323203) /Source="Nicolas_S_feature" /locus_tag="new_2736537_2736639_c" /HighExp="M9-stat, T3.0H, T0.30H, T1.30H, T2.30H, Lbtran, T3.30H, T1.0H, M0t90, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1005" promotor_-10 complement(2323184..2323203) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2323201) /Source="Nicolas_upshifts" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2323218..2323221) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2323372..2323379 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2323393..2323412 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2323408 /Source="Nicolas_upshifts" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2323413..2323478 /Source="Nicolas_S_feature" /locus_tag="new_2736849_2736914" /HighExp="LoTm, BC, S1, S2, C90, T4.0H, HiOs, T5.0H, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.894" /TUlongSig="NA" /TUlongPSig="NA" /label="S1006" CDS 2323479..2324522 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /EC_number="1.13.12.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9501443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative anionic nitroalkane monoxygenase" /protein_id="NP_390557.1" /db_xref="EnsemblGenomes-Gn:BSU26800" /db_xref="EnsemblGenomes-Tr:CAB14621" /db_xref="GOA:O05413" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12305" /db_xref="UniProtKB/Swiss-Prot:O05413" /translation="MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASG YLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTS VQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLM EERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHR GVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIV NKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVK QLLNQLCQEDIKI*" /label="yrpB CDS" gene 2323479..2324522 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /label="yrpB gene" downshifts 2324520 /Source="Nicolas_upshifts" /id="D1370" /incds=0 /nref=22 /ntot=198 /MaxReadThrough="1.3622" /MaxDrop="5.04821" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-35 2324807..2324814 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-35" upshifts 2324821 /Source="Nicolas_upshifts" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="upshifts" promotor_-10 2324828..2324847 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-10" CDS 2324872..2325669 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /EC_number="5.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12829290, 15212785, 15347750, 17720142, 25777674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12829290, 15212785, 15347750, 17720142, 25777674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390558.1" /db_xref="EnsemblGenomes-Gn:BSU26810" /db_xref="EnsemblGenomes-Tr:CAB14622" /db_xref="GOA:O05412" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="SubtiList:BG12306" /db_xref="UniProtKB/Swiss-Prot:O05412" /translation="MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSK GKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINK CTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKII KYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLA DRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH*" /label="murI CDS" gene 2324872..2325669 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /label="murI gene" promotor_-35 2325975..2325979 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2325993..2326012 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2326003 /Source="Nicolas_upshifts" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2326027..2326041) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326041) /Source="Nicolas_upshifts" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2326050..2326054) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2326050..2326757 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390559.1" /db_xref="EnsemblGenomes-Gn:BSU26820" /db_xref="EnsemblGenomes-Tr:CAB14623" /db_xref="InterPro:IPR029143" /db_xref="SubtiList:BG12307" /db_xref="UniProtKB/Swiss-Prot:O05411" /translation="MMKKGLLAGALTATVLFGTCAVDVPGIISPKTAEAASQLTDGIG GRAYLNSNGAILVTKIQLPSSTQVSNGTAYIYSGFSGGTESDIGFQYSDKYNVWKPYM KVGSKGQDQVQYLEGGSQFTNTKGFRPGSTVQLTIYKNLNGNTRATYWGTNNAGYNGR LISEISKTNVGSISKWKALATVATTGSRQSIKSNFSTSFTNITIDNKAITPVIDTQDF AKVTVSGNSVSLSVVKN*" /label="yrpD CDS" gene 2326050..2326757 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /label="yrpD gene" downshifts 2326757 /Source="Nicolas_upshifts" /id="D1371" /incds=0 /nref=4 /ntot=168 /MaxReadThrough="5.98921" /MaxDrop="2.677" /score="15.7112026" /energy="-8.2" /TU="U2062" /idTUdmin="U2064" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" S_feature 2326802..2326975 /Source="Nicolas_S_feature" /locus_tag="new_2740238_2740411" /HighExp="Lbstat, M0t90, M40t90, BT, S0, ferm, S2, M9-stat, Lbtran, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig=1 /label="S1007" promotor_-35 2326957..2326958 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2326974..2326993 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2326977..2327305 /Source="Nicolas_S_feature" /locus_tag="new_2740413_2740741" /HighExp="Lbstat, M0t90, BT, M40t90, S2, S0, ferm, T2.0H, M9-stat, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99711000000000005" /TUshortSig="SigA, SigA" /TUshortPSig="0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1008" upshifts 2326977 /Source="Nicolas_upshifts" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="upshifts" CDS 2327081..2327242 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90581.1" /translation="MYFHKRGMASYSSIASGRLANDWPRTTHHFETDSFQNHKYDPIT NKDQLAVQP*" /label="hypothetical protein CDS" gene 2327081..2327242 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /pseudo /label="gene" promotor_-35 2327271..2327280 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2327293..2327312 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2327307..2327458 /Source="Nicolas_S_feature" /locus_tag="new_2740743_2740894" /HighExp="BT, S8, B36, S7, Lbstat, G/S, Pyr, M0t90, B60, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94474599999999997" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1009" upshifts 2327307 /Source="Nicolas_upshifts" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="upshifts" CDS 2327333..2327410 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /experiment="publication(s) with functional evidences, PMID:20709900" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="expressed polypeptide of unknown function" /protein_id="YP_009513985.1" /db_xref="EnsemblGenomes-Gn:BSU26826" /db_xref="EnsemblGenomes-Tr:CCQ48602" /db_xref="GOA:L8E9J8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8E9J8" /translation="MRSFPLIVVLFILLIIVGTSFFGGY*" /label="yrpDX CDS" gene 2327333..2327410 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /label="yrpDX gene" downshifts 2327415 /Source="Nicolas_upshifts" /id="D1372" /incds=0 /nref=23 /ntot=198 /MaxReadThrough="3.86249" /MaxDrop="4.0885" /score="28.4802594" /energy="-18.1" /TU="U2062,U2065" /idTUdmin="U2064" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature 2327460..2327657 /Source="Nicolas_S_feature" /locus_tag="new_2740896_2741093" /HighExp="BT, B36, S8, Lbstat, G/S, Pyr, Diami, S7, dia15, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1010" S_feature complement(2327649..2327920) /Source="Nicolas_S_feature" /locus_tag="new_2741085_2741356_c" /HighExp="Heat, BMM, Etha, S2, S3, S4, B36, S5, B60, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40965600000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1011" downshifts complement(2327691) /Source="Nicolas_upshifts" /id="D1373" /incds=0 /nref=37 /ntot=78 /MaxReadThrough="2.30607" /MaxDrop="6.9537" /score="19.9821634" /energy="-15.5" /TU="NA" /idTUdmin="U2066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2327697..2327858) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513986.1" /translation="MGKKLIETIQYPPYYCDVAYLESSHMKSRRNLFQNKKSLDVWQW ITLEIYWLI*" /label="hypothetical protein CDS" gene complement(2327697..2327858) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /label="gene" CDS complement(2327921..2328676) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /function="16.14: Store" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 24128931; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein buffering protein for Zn2+ transport" /protein_id="NP_390560.1" /db_xref="EnsemblGenomes-Gn:BSU26830" /db_xref="EnsemblGenomes-Tr:CAB14624" /db_xref="GOA:O05410" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015304" /db_xref="SubtiList:BG12308" /db_xref="UniProtKB/Swiss-Prot:O05410" /translation="MNILFSKRLGILTIGSLLVLAGCQTSGSSAGESNQTTSSSAVEE DSSKTQEQTSDSHTHEHSHDHSHAHDEETEKIYEGYFKNSQVKDRLLSDWEGDWQSVY PYLQDGTLDEVFSYKSEHEGGKTAEEYKEYYKKGYQTDVDRIVIQKDTVTFFKNGKEY SGKYTYDGYEILTYDAGNRGVRYIFKLAKKAEGLPQYIQFSDHSIYPTKASHYHLYWG DDREALLDEVKNWPTYYPSKMDGHDIAHEMMAH*" /label="zinT CDS" gene complement(2327921..2328676) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /label="zinT gene" promotor_-10 complement(2328707..2328726) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2328723) /Source="Nicolas_upshifts" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2328742..2328747) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2328808..2329338) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2328808..2329338) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2329384..2329403) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2329407) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2329417..2329424) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2329473..2330453 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2329473..2330453 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2330727..2332043) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2330727..2332043) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2332044..2332157) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2332158..2333027) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2332158..2333027) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2333050..2333069) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333067) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2333084..2333089) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2333134..2333135) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333142) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2333172..2333173) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2333172..2334275 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2333172..2334275 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2334165..2334184 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2334171 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2334522) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2334548..2335381) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2334548..2335381) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2335411..2335430) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2335420) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2335586..2335590 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2335601..2335823 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2335601 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2335605..2335624 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2335824..2336087 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2335824..2336087 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2336075 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2336224..2337039 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2336224..2337039 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2337374..2337446) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2337417) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2337447..2337803) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2337447..2337803) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2337856..2338215) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2337856..2338215) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2338308..2338327) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2338318) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2338487..2338588) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2338487..2338588) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2338628..2338730) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2338670) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2338731..2339117) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2338731..2339117) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2339159..2339175) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2339175) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2339308..2339314 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2339329..2339340 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2339329 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2339366..2339611 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2339366..2339611 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2339629..2339997 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2339629..2339997 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2340016..2341152 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2340016..2341152 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2341171..2341368 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2341171..2341368 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2341384..2341683 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2341384..2341683 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2341674 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2341946..2342368) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2341946..2342368) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2342366..2342369 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2342385..2342404 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2342400..2342550 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2342400 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2342403..2342422) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2342410) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2342436..2342443) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2342519..2342538) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2342527) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2342551..2342745 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2342551..2342745 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2342553..2342560) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2342763..2342770 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2342786..2342805 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2342790 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2342791..2342875 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2342876..2343925 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2342876..2343925 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2343993..2344000 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2344015..2344034 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2344028 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2344056..2344565 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2344056..2344565 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2344534 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2344579..2345684 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2344607..2346640) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2344607..2346640) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2344632) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2346549..2346716) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2346549..2346716) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2346641..2346796) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2346797..2347624) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2346797..2347624) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2347645..2348454) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2347645..2348454) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2348471..2348959) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2348471..2348959) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2348959..2349399) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2348959..2349399) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2349396 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2349436..2349454) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2349440) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2349589..2352396) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2349589..2352396) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2352612..2352631) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2352618) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2352943..2353083 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2352943..2353083 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2353064..2353083 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2353074 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2353122..2354510 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2353122..2354510 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2354499 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2354532..2354605) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2354574) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2354606..2355238) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2354606..2355238) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2354662) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2355292..2355311) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2355303) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2355317..2355323 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2355326..2355333) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2355337..2355356 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2355342 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2355391..2356218 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2355391..2356218 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2356214 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2356331..2356340 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2356353..2356368 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2356358 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2356414..2356914 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2356414..2356914 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2356914..2357771 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2356914..2357771 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2357789..2357800) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2357808) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2357815..2357821) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2357882..2359786 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2357882..2359786 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2359867..2359873 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2359889..2359907 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2359895 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2359920..2360210 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2359920..2360210 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2360211..2360326 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2360308..2360315 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2360328..2360453 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2360328 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2360329..2360347 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2360347..2360447 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2360347..2360447 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2360410 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2360454..2363618) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2360454..2363618) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2360470) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2361604..2361613 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2361627..2361646 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2361648 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2363634..2364218) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2363634..2364218) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2364441..2364983) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2364441..2364983) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2364984..2365069) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2365067..2365082) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2365069) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2365095..2365104) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2365138..2365354) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2365172..2365330) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2365172..2365330) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2365181) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2365352..2365371) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2365354) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2365356..2365486) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2365385..2365394) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2365487..2365636) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2365487..2365636) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2365630 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2365637..2365727) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2365729..2365948) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2365772) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2365894 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2365927..2365946) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2365948) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2365950..2366025) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2365961..2365968) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2366026..2366826) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2366026..2366826) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2366895..2367048) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2366938) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2367039..2367058) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2367048) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2367073..2367079) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2367089..2367457) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2367089..2367457) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2367458..2367554) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2367540..2367559) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2367544..2367547 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2367560) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2367563..2367582 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2367565 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2367566..2367772 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2367575..2367579) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2367773..2370715 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2367773..2370715 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2370734..2371216 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2370734..2371216 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2371196 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2371252..2371482) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2371252..2371482) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2371272) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2371483..2371564) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2371565..2372704) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2371565..2372704) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2372706..2373629) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2372706..2373629) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2373622) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2373630..2373693) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2373694..2374389) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2373694..2374389) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2374129..2374148) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2374147) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2374161..2374170) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2374410..2375051) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2374410..2375051) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2374618..2374637) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2374637) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2374654..2374657) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2375103..2375112 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2375109..2375128) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375115) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2375125..2375144 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2375134..2375198 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2375134 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2375144..2375147) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2375179..2375186 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2375200 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2375202..2375219 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2375244..2375447 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2375244..2375447 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2375454 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2375484..2376185) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2375484..2376185) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2375496) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2376250..2378004) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2376250..2378004) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2376278..2376297) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2376288) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2377319..2377334) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2377322) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2377347..2377356) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2377550..2377568) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2377564) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2377583..2377590 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2377583..2377588) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2377605..2377624 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2377610 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2378058..2378531) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2378058..2378531) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2378065) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2378532..2378664) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2378646..2378665) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2378664) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2378666..2378774) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2378679..2378686) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2378767..2378786) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2378774) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2378782..2379417) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2378782..2379417) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2378802..2378806) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2378912..2378917 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2378933..2378951 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2378940 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2379424..2380692) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2379424..2380692) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2380711..2381640) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2380711..2381640) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2381646..2382299) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2381646..2382299) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2382300..2382404) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2382386..2382405) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2382404) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2382421..2382425) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2382451..2383533) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2382451..2383533) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2382485) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2383549..2383568) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383569) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2383583..2383586) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2383659) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2383664..2383945) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2383664..2383945) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2383724) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2383963..2384379) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2383963..2384379) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2384211..2384229) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384230) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2384245..2384250) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2384387..2384653) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2384387..2384653) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2384541..2384549 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2384564..2384583 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2384572..2385761 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2384572 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2384654..2384714) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2384708..2384727) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384714) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2384738..2387374) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2384738..2387374) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2384741..2384748) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2387140..2387158) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387156) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2387172..2387179) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2387375..2387453) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2387454..2387661) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2387454..2387661) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2387669..2387688) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387684) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2387703..2387710) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2387705..2388766) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2387705..2388766) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2388675..2388680 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2388686..2388921 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2388687 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2388696..2388714 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2388783..2388794) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2388784) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2388808..2388814) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2388922..2389650 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2388922..2389650 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2389378) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2389672..2390493 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2389672..2390493 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2390554..2391204 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2390554..2391204 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2391221..2391877 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2391221..2391877 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2391876 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2391912..2392043) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2391912..2392043) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2391930) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2392065..2392256) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2392065..2392256) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2392268..2392792) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2392268..2392792) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2392379) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2392383..2392394) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2392409..2392415) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2392763..2392774) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2392769) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2392789..2392795) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2392850..2395246) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2392850..2395246) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2392876) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2393096..2393102 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2393110 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2393117..2393128 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2393130..2393479 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2393231) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2395271..2395891) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2395271..2395891) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2395977..2397092) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2395977..2397092) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2395978) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2397123..2398262) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2397123..2398262) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2397829..2397848) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397841) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2397862..2397869) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2398281..2398697) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2398281..2398697) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2398698..2398795) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2398780..2398799) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2398795) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2398815..2398818) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2398843..2398850 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2398864..2398883 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2398872 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2398900..2400165 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2398900..2400165 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2400164 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2400207..2400971) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2400207..2400971) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2400225) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2401055..2401255) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2401055..2401255) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2401073) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2401242 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2401243..2401252 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2401253..2401272) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2401264) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2401285..2401292) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2401307..2403085) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2401307..2403085) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2403099..2404373) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2403099..2404373) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2404463..2404695) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2404463..2404695) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2404493) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2404705..2404708 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2404719..2404738) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2404723..2404742 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2404725..2405009 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2404725 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2404738) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2404753..2404760) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2404755..2404925) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2404755..2404925) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2404956..2404967) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2404973) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2404982..2404988) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2404985..2404992 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2405006..2405024 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2405011 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2405058..2406614 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2405058..2406614 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2406593 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2406641..2407039) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2406641..2407039) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2406649) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2407093..2409297) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2407093..2409297) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2409326..2409345) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2409333) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2409335..2409425) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2409360..2409367) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2409389 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2409465..2409977) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2409465..2409977) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2409470) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2409983..2412343) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2409983..2412343) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2410447..2410466) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2410455) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2410480..2410489) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2412357..2412376) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2412368) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2412391..2412397) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2412410..2412733) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2412410..2412733) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2412754..2412772) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2412765) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2412787..2412793) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2412809..2413306) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2412809..2413306) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2413307..2413382) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2413376..2413395) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2413382) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2413409..2413416) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2413464..2415677) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2413464..2415677) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2413469) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2415236..2415241 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2415255..2415274 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2415263 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2415716..2416012) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2415716..2416012) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2415923 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2416013..2416091) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2416053..2416058 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2416075..2416093 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2416077..2416096) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2416077 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2416091) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2416093..2417011) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2416111..2416114) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2416128..2417684 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2416128..2417684 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2416997..2417015) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2417011) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2417027..2417035) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2417685..2418449 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2417688..2418344) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2417688..2418344) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2418363..2418374) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2418375) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2418388..2418394) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2418427..2418432 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2418448..2418466 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2418451 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2418479..2418931 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2418479..2418931 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2418915 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2418970) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2418988..2419254) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2418988..2419254) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2419291..2420436) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2419291..2420436) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2419343) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2419387) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2419389..2419408) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2419423..2419428) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2420463..2421491) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2420463..2421491) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2421521..2421721) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2421521..2421721) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2421714..2422718) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2421714..2422718) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2422729..2423334) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2422729..2423334) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2423353..2423372) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2423369) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2423371..2423472) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2423383..2423389) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2423473..2423985) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2423473..2423985) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2424014..2424025) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2424029) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2424033..2425340) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2424033..2425340) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2424040..2424046) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2425294) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2425364..2425382) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2425379) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2425397..2425403) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2425411..2426436) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2425411..2426436) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2426473..2426492) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2426493) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2426507..2426514) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2426562..2426569 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2426583..2426602 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2426591 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2426623..2426628 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2426637 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2426644..2426662 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2426674..2427321 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2426674..2427321 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2426996..2427329) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2427300 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2427331..2427528) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2427367..2427489) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2427367..2427489) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2427374) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2427537) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2427538..2427555) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2427562..2427569) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2427574..2427864 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2427574..2427864 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2427585..2427604 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2427585..2427732 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2427585 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2427871..2428011 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2427871..2428011 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2428000 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2428060..2428066 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2428074..2428174 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2428081..2428099 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2428082 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2428134 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2428175..2429629 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2428175..2429629 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2429630 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2429670..2430392) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2429670..2430392) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2429675..2430096 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2429686) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2430415..2430434) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2430432) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2430448..2430455) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2430495..2431091) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2430495..2431091) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2430510) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2431134..2431145) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2431136) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2431138..2431202) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2431160..2431166) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2431239..2432402) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2431239..2432402) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2431247) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2432403..2432478) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2432454..2432472) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2432478) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2432488..2432493) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2432519..2433625) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2432519..2433625) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2433201..2433219) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2433226) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2433235..2433240) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2433537 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2433538..2433541 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2433612..2434481) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2433612..2434481) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2433706 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2434435..2436030) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2434435..2436030) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2436058..2436065 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2436058..2436077) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2436079 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2436081..2436100 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436082) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2436092..2436099) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2436133..2437320 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2436133..2437320 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2436134..2436153) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436152) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2436168..2436177) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2437035..2437040 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2437049 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2437051..2437070 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2437280..2437822 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2437280..2437822 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2437805 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2437847..2438704) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2437847..2438704) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2437850..2438559 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2437867) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2438721..2439164) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2438721..2439164) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2439225..2440511) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2439225..2440511) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2440545..2441123) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2440545..2441123) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2441124..2441189) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2441174..2441193) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2441189) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2441191..2441408) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2441201..2441323 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2441201..2441323 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2441207..2441214) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2441444..2441728) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2441444..2441728) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2441453) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2441741..2442079) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2441741..2442079) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2442082..2442390) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2442082..2442390) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2442404..2442479) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2442404..2442479) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2442491..2442510) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2442511) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2442524..2442531) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2442537..2443403) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2442537..2443403) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2443396..2444190) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2443396..2444190) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2444193 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2444199..2444299 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2444214..2444232) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2444225) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2444248..2444253) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2444259 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2444302 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2444337) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2444340..2445146) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2444340..2445146) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2445148..2445828) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2445148..2445828) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2445881..2446399) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2445881..2446399) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2446396..2447268) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2446396..2447268) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2447299..2448312) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2447299..2448312) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2448353) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2448365..2448383) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2448404..2449099) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2448404..2449099) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2449136..2449705) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2449136..2449705) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2449557..2449572) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449566) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2449585..2449594) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2449744..2449763) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449760) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2449777..2449783) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2449856) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2449858..2450856) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2449858..2450856) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2450903..2450922) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450911) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2450934..2450941) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2450979) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2450990..2451736) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2450990..2451736) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2451764..2451783) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2451771) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2451798..2451805) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2451876..2453168) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2451876..2453168) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2451881) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2453169..2453227) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2453228..2455870) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2453228..2455870) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2455871..2455929) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2455930..2456152) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2455930..2456152) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2455973) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2456181..2456200) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456193) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2456195..2456303) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2456215..2456220) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2456257..2456266 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2456279..2456298 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2456280 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2456296..2456310) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456303) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2456318..2456322) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2456318..2456509 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2456318..2456509 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2456528..2457553) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2456528..2457553) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2456558) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2457586..2459313) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2457586..2459313) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2458915..2458918 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2458934..2458953 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2458940 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2459309..2459313 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2459322..2459336 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2459336 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2459351..2459369) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2459367) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2459385..2459390) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2459444..2460736) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2459444..2460736) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2459461) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2460766..2461740) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2460766..2461740) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2461737..2462525) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2461737..2462525) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2462515..2463459) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2462515..2463459) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2463492..2464322) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2463492..2464322) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2464330..2465697) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2464330..2465697) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2465761..2465780) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2465767) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2465769..2465858) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2465818..2465837 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2465826 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2465855..2465874) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2465858) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2465860..2466276) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2465885..2465893) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2465927..2466424 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2465927..2466424 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2466260..2466278) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2466276) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2466278..2466408) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2466294..2466300) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2466388..2466399) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2466408) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2466414..2466420) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2466446..2467033) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2466446..2467033) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2466474) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2467030..2469354) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2467030..2469354) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2469355..2469466) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2469451..2469470) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2469466) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2469484..2469491) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2469535..2471193) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2469535..2471193) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2469554) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2471237..2471255) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2471248) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2471271..2471276) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2471345..2472607) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2471345..2472607) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2471355) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2472608..2472697) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2472685..2472704) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472697) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2472699..2472830) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2472716..2472723) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2472875) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2472879..2474153) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2472879..2474153) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2474154..2474343) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2474330..2474349) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474343) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2474364..2474368) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2474381..2475385) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2474381..2475385) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2475410..2475429) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2475428) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2475441..2475448) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2475504..2476103) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2475504..2476103) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2475525) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2476116..2477534) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2476116..2477534) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2477423..2477427 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2477442..2477446 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2477442 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2477584..2478681) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2477584..2478681) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2478702..2480258) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2478702..2480258) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2479098..2479101 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2479114..2481555 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2479114 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2479116..2479135 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2480245..2481273) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2480245..2481273) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2481297..2481815) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2481297..2481815) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2481536..2481539 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2481555..2481559 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2481557 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2481812..2483536) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2481812..2483536) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2483537..2483657) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2483658..2483904) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2483658..2483904) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2483701) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2483905..2484031) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2484013..2484032) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2484031) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2484033..2484163) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2484047..2484054) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2484158..2484177) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2484167) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2484191..2484194) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2484289..2484298 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2484312..2484331 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2484314 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2484352..2484687 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2484352..2484687 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2484681 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2484768..2484775 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2484789..2484808 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2484791..2484855 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2484791 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2484856..2485311 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2484856..2485311 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2485419..2485425 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2485439..2485457 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2485446 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2485495..2486316 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2485495..2486316 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2486309 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2486373 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2486380..2486453) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2486380..2486453) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2486414) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2486490..2486509) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2486493) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2486523..2486530) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2486584..2487093) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2486584..2487093) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2486601) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2487109..2487705) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2487109..2487705) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2487718..2488455) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2487718..2488455) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2488537..2488556) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488553) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2488566..2489666) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2488566..2489666) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2488571..2488576) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2488583) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2489689..2489707) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489705) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2489722..2489727) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2489781..2490599) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2489781..2490599) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2489793) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2490607..2491047) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2490607..2491047) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2491090..2491109) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2491099) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2491101..2491243) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2491125..2491129) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2491288) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2491291..2491515) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2491291..2491515) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2491564 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2491566..2491584 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2491573..2491592) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2491593) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2491606..2491615) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2491631..2492074) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2491631..2492074) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2492135..2492896) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2492135..2492896) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2492143) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2492899..2494659) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2492899..2494659) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2494693..2495301) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2494693..2495301) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2495071..2495078 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2495091..2495110 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2495093 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2495302..2495397) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2495387..2495406) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2495397) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2495399..2496020) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2495421..2495428) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2495536..2495540 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2495550..2495650 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2495557..2495576 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2495566 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2495594..2496040 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2495594..2496040 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2495610 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2496028 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2496066) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2496084..2497310) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2496084..2496575) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2496084..2497310) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2496084..2496575) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2497424) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2497436..2497615) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2497436..2497615) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2497468) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2497640..2497659) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2497647) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2497672..2497679) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2497680..2499452) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2497680..2499452) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2499479..2499498) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2499493) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2499512..2499519) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2499582) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2499588..2499902) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2499588..2499902) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2499928..2499947) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2499942) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2499944..2500153) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2499963..2499965) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2500047..2500157) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2500047..2500157) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2500143..2500161) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2500153) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2500176..2500182) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2500225..2501712) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2500225..2501712) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2501713..2501825) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2501806..2501825) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2501825) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2501840..2501847) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2501929..2502906) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2501929..2502906) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2501937) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2502942..2503715) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2502942..2503715) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2503730..2504506) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2503730..2504506) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2503795 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2504521..2505105) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2504521..2505105) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2505147..2505166) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2505147) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2505179..2505186) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2505210..2506892) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2505210..2506892) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2506921..2506940) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2506929) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2507017) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2507081..2507485) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2507081..2507485) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2507083) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2507500..2509857) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2507500..2509857) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2509878..2511590) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2509878..2511590) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2511591..2511663) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2511664..2512197) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2511664..2512197) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2512204..2512461) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2512204..2512461) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2512488..2512507) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2512504) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2512519..2512526) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2512544..2512563 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2512551 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2512595..2513536 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2512595..2513536 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2513268..2513287) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2513283) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2513301..2513308) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2513519 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2513551) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2513572..2515986) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2513572..2515986) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2513595) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2516002..2517036) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2516002..2517036) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2517037..2517357) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2517118..2517324 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2517118..2517324 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2517347..2517611 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2517347 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2517352..2517371) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2517354..2517368 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2517357) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2517386..2517389) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2517391..2518137) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2517391..2518137) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2518164..2518183) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2518170..2518176 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2518177) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2518190..2518201 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2518197..2518203) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2518204 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2518256..2518471 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2518256..2518471 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2518453..2519865) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2518482..2518489 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2518505..2518524 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2518513 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2518540..2519646 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2518540..2519646 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2519682..2519685 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2519701..2519720 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2519705 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2519749..2521161 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2519749..2521161 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2519851..2519870) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2519865) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2519883..2519892) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2521158..2522492 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2521158..2522492 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2522191,2522193) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2522490 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2522529) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2522531..2522773) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2522531..2522773) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2522774..2522945) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2522833..2523003) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2522833..2523003) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2522946..2524742) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2522946..2524742) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2523048..2523066) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2523066) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2523078..2523086) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2524739 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2524767..2524786) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2524777) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2524801..2524807) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2524837..2524893) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2524861) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2524894..2526396) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2524894..2526396) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2526267) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2526371..2526471) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2526411) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2526415..2527260) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2526415..2527260) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2527261..2528202) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2527261..2528202) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2528238..2529539) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2528238..2529539) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2529570..2530754) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2529570..2530754) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2530751..2531569) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2530751..2531569) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2531547..2532236) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2531547..2532236) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2532253..2533935) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2532253..2533935) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2533949..2535439) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2533949..2535439) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2535532..2535551) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2535539) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2535541..2535616) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2535566..2535573) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2535617..2536588) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2535617..2536588) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2536589..2536717) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2536702..2536721) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2536717) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2536736..2536739) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2536785..2537870) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2536785..2537870) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2536799) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2537896..2537915) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2537919) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2537930..2537937) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2537988..2537997 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2538003 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2538009..2538024 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2538054..2538446 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2538054..2538446 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2538417 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2538462..2538768 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2538462..2538731) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2538462..2538731) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2538478) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2538647) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2538725 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2538788..2539147) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2538788..2539147) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2538801) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2539179..2539379) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2539179..2539379) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2539392..2539913) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2539392..2539913) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2539975..2540114) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2539975..2540114) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2540111..2540130) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2540121) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2540123..2540187) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2540144..2540151) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2540169..2540188) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2540187) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2540204..2540208) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2540306..2540313 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2540327..2540345 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2540327 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2540359..2541024 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2540359..2541024 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2541002 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2541056..2541751) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2541056..2541751) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2541078) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2541122) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2541773..2542213) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2541773..2542213) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2542235..2542254) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2542254) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2542270..2542273) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2542347..2543072) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2542347..2543072) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2542376) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2543050..2544831) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2543050..2544831) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2544915..2544918 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2544927..2544946) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2544932) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2544933..2544952 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2544940 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2544998..2545780 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2544998..2545780 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2545764 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2545814) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2545821..2547752) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2545821..2547752) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2547796..2548043) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2547796..2548043) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2547799..2547808) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2547799) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2547854) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2548054..2548073) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2548067) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2548069..2548149) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2548089..2548093) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2548150..2548995) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2548150..2548995) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2549015..2549033) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2549021) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2549049..2549054) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2549074..2549715) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2549074..2549715) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2549749..2550684) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2549749..2550684) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2550712..2552130) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2550712..2552130) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2552159..2552178) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2552167) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2552193..2552196) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2552245..2552703) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2552245..2552703) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2552264) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2552704..2552851) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2552842..2552861) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2552851) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2552853..2552931) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2552876..2552879) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2552976) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2552977..2553357) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2552977..2553357) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2553358..2553512) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2553492..2553511) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2553499 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2553500..2553519 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2553512) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2553526..2553532) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2553590..2553601) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2553596..2554618) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2553596..2554618) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2553597) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2553616..2553622) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2554662..2554681) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2554693) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2554694..2554701) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2554824..2555204) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2554824..2555204) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2554848) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2555205..2555335) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2555260..2555264 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2555280..2555299 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2555281..2555387 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2555281 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2555325..2555344) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2555335) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2555359..2555366) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2555388..2556578 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2555388..2556578 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2556210..2556228) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556226) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2556244..2556249) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2556602..2557444 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2556602..2557444 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2557217..2557222 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2557238..2557256 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2557239 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2557437 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2557477) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2557486..2558079) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2557486..2558079) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2558095..2558727) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2558095..2558727) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2558728..2558892) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2558893..2559723) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2558893..2559723) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2559746..2562388) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2559746..2562388) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2562443..2562462) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562452) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2562476..2562483) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2562512..2562631) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2562555) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2562632..2564371) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2562632..2564371) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2564364..2565086) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2564364..2565086) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2565154..2565173) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565164) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2565166..2565266) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2565187..2565193) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2565298..2566236) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2565298..2566236) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2565311) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2566280..2567551) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2566280..2567551) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2567336..2567355) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2567348) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2567552..2567634) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2567634) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2567636..2567714) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2567636..2567655) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2567671..2567675) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2567715..2568833) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2567715..2568833) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2568328 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2568675..2568678 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2568683 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2568812 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2568834..2569040) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2569008..2569020 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2569019 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2569026..2569045) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2569040) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2569060..2569064) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2569160) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2569167..2569631) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2569167..2569631) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2569644..2569663) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2569658) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2569660..2570845) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2569660..2569665 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2569676..2569684) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2569680..2569698 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2569686 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2569728..2570843 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2569728..2570843 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2570814 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2570876..2571259) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2570876..2571259) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2570890) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2571260..2571351) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2571352..2573109) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2571352..2573109) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2573152..2574111) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2573152..2574111) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2574112..2574213) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2574202..2574221) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2574213) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2574237..2574241) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2574295..2575272) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2574295..2575272) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2574322) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2575257..2576129) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2575257..2576129) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2576091..2576096 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2576112..2576130 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2576116..2577290 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2576116 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2576130..2576213) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2576202..2576221) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2576213) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2576215..2576367) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2576237..2576241) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2576369..2576463) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2576412) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2576464..2577696) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2576464..2577696) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2577697..2577813) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2577801..2577820) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2577813) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2577833..2581180) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2577833..2581180) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2577834..2577841) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2578845..2578854 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2578866..2578881 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2578866 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2579054..2579073) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2579073) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2579087..2579094) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2581211..2581230) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2581229) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2581244..2581251) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2581269..2581274 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2581286 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2581290..2581308 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2581320..2581661 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2581320..2581661 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2581658..2582161 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2581658..2582161 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2582194..2582197 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2582212..2582231 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2582212 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2582263..2582454 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2582263..2582454 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2582264) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2582430 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2582472..2583413) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2582472..2583413) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2582475..2582846 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2582507) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2582815..2582824 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2582838..2582857 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2582848..2583242 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2582848 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2583204..2583210 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2583226..2583245 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2583244..2583543 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2583244 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2583432..2583451) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2583448) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2583450..2583864) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2583466..2583469) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2583544..2583846 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2583544..2583846 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2583847..2585642 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2583865..2585184) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2583865..2585184) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2585210..2585229) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2585231) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2585244..2585249) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2585360..2586262) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2585360..2586262) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2586281..2587531) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2586281..2587531) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2587549..2588241) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2587549..2588241) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2588288..2589616) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2588288..2589616) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2589613..2589894) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2589613..2589894) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2589909..2590913) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2589909..2590913) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2590910..2591689) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2590910..2591689) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2591686..2592393) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2591686..2592393) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2592423..2593142) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2592423..2593142) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2592968..2592975 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2592990..2593009 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2592990 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2593164..2593976) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2593164..2593976) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2593990..2594799) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2593990..2594799) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2594813..2595349) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2594813..2595349) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2595386..2595393 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2595404..2595423) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2595407..2595426 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2595410..2595501 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2595410 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2595420) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2595437..2595444) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2595502..2596428 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2595502..2596428 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2595904..2596433) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2596478) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2596479..2597162) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2596479..2597162) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2597163..2597224) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2597225..2597992) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2597225..2597992) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2598037..2598056) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2598059) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2598072..2598074) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2598119..2598355) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2598119..2598355) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2598204 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2598224) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2598315..2599700) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2598315..2599700) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2599697..2600908) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2599697..2600908) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2600909..2600986) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2600979..2600998) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2600985) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2601013..2601020) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2601078..2601590) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2601078..2601590) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2601096) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2601616..2601635) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2601624) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2601649..2601656) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2601675..2602862) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2601675..2602862) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2601690) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2602863..2602967) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2602952..2602971) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2602967) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2602969..2603098) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2602987..2602991) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2603035..2603238) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2603035..2603238) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2603096..2603107) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2603098) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2603122..2603128) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2603210..2604199) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2603210..2604199) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2603228) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2604260..2604763) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2604260..2604763) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2604266) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2604480..2604580 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2604540 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2604759 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2604786..2604805) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2604802) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2604819..2604826) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2604873..2605328) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2604873..2605328) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2604901) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2605342..2606022) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2605342..2606022) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2605434) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2605441..2605452) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2605467..2605473) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2605760) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2606035..2606053) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2606049) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2606068..2606073) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2606097..2606591) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2606097..2606591) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2606112) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2606604..2607611) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2606604..2607611) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2607635..2607650) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2607652) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2607654..2607733) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2607662..2607671) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2607711..2607730 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2607721 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2607726..2607745) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2607730..2607796 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2607733) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2607761..2607765) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2607797..2608600 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2607797..2608600 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2608530 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2608588 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2608632..2610221) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2608632..2610221) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2608641) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2610241..2611830) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2610241..2611830) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2611876..2611893) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611881) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2611909..2611915) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2612008) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2612009..2612218) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2612009..2612218) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2612214..2612218 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2612218 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2612227..2612241 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2612239..2612250) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612250) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2612265..2612271) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2612312..2613517) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2612312..2613517) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2613521..2614666) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2613521..2614666) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2614667..2615810) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2614753..2614760 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2614771..2614860 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2614771 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2614773..2614792 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2614861..2616198 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2614861..2616198 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2615796..2615815) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2615810) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2615830..2615837) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2616174 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2616293..2617981) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2616293..2617981) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2616294) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2617982..2618087) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2618064..2618072 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2618075..2618094) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2618083..2618102 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2618087) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2618087 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2618088..2618177 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2618089..2618648) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2618110..2618112) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2618178..2618984 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2618178..2618984 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2618652..2618671) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2618665) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2618683..2618690) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2618934..2618980) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2618956) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2618981..2619604) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2618981..2619604) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2618985..2619327 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2619305..2619312 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2619327..2619346 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2619329..2619472 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2619329 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2619444..2619448 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2619464..2619483 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2619474..2619604 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2619474 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2619606..2619730 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2619606 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2619620..2619638) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2619622..2619641 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2619638) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2619649..2619657) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2619731..2620222 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2619731..2620222 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2620201 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2620260..2621999) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2620260..2621999) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2620278) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2621473..2621480 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2621494..2621512 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2621497 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2621499..2622094 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2622029..2622048) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2622037) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2622039..2622872) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2622075..2622082 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2622096..2622293 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2622096..2622115 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2622096 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2622153..2622285 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2622153..2622285 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2622294..2622896 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2622294..2622896 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2622819 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2622874..2623093) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2622882 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2622917) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2622929 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2622974..2623147 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2623089..2623107) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2623101) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2623105 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2623122..2623128) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2623167..2624435) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2623167..2624435) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2623193) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2624459..2624732) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2624459..2624732) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2624480..2624623) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2624523) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2624730..2624749) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2624742) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2624762..2624769) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2624777..2626495) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2624777..2626495) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2626509..2626516 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2626523..2626542) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2626531..2626550 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2626537 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2626546) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2626556..2626562) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2626579..2626586 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2626600..2626619 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2626603 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2626656..2627288 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2626656..2627288 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2626861..2626869 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2626883..2626902 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2626889 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2627315..2627959 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2627315..2627959 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2627956..2629119 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2627956..2629119 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2629110 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2629130..2629858) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2629130..2629858) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2629166) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2629848..2630666) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2629848..2630666) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2630729..2631733) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2630729..2631733) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2630746) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2631768..2631787) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2631783) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2631785..2631893) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2631893..2631912) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2631893) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2631895..2631960) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2631926..2631932) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2632006) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2632009..2633085) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2632009..2633085) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2633126..2633145) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2633146) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2633148..2633248) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2633160..2633167) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2633182 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2633236..2633255) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2633248) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2633269..2633275) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2633321..2633647) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2633321..2633647) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2633330) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2633671..2634126) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2633671..2634126) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2634157..2634579) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2634157..2634579) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2634600..2634618) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2634613) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2634632..2634638) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2634652..2634670) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2634661) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2634681..2634689) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2634741..2636039) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2634741..2636039) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2634750) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2636064..2636083) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2636065) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2636067..2636263) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2636096..2636105) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2636246..2636265) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2636263) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2636277..2636283) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2636289..2639147) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2636289..2639147) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2639181..2639200) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2639191) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2639216..2639220) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2639290) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2639307..2639912) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2639307..2639912) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2639928..2640737) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2639928..2640737) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2640752..2641075) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2640752..2641075) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2641076..2641214) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2641114..2641230) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2641114..2641230) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2641201..2641220) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2641214) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2641222..2641229 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2641244..2641263 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2641249 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2641310..2641756 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2641310..2641756 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2641757..2642485 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2641811..2642884) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2641811..2642884) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2641830) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2642906..2642925) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642910) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2642939..2642946) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2642981..2642984 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2642999..2643018 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2643004 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2643043..2643360 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2643043..2643360 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2643360 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2643413..2645113) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2643413..2645113) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2643432) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2645145..2645163) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2645152) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2645178..2645184) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2645195..2645965) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2645195..2645965) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2645966..2646054) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2646052..2646071) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2646054) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2646087..2646091) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2646111..2646752) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2646111..2646752) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2646121) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2646186) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2646778..2646797) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2646787) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2646789..2647237) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2646813..2646817) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2646896..2646902 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2646917..2646928 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2646924 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2646959..2647237 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2646959..2647237 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2647238..2647408 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2647238..2647852) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2647238..2647852) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2647386 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2647853..2648188) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2648180..2648199) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2648188) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2648214..2648221) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2648215..2650371) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2648215..2650371) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2649912,2649914) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2650397..2651326) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2650397..2651326) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2651375..2652289) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2651375..2652289) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2652052..2652070) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2652060) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2652084..2652090) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2652315..2652866) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2652315..2652866) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2652729..2652748 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2652732 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2652889..2652908) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2652901) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2652924..2652927) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2652949..2652956 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2652967..2652986 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2652970..2652981) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2652974 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2652984) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2652995..2653001) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2653015..2653950 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2653015..2653950 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2653926 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2653984..2655375) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2653984..2655375) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2653996) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2655376..2655816) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2655402..2655407 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2655421..2655440 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2655434 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2655472..2656770 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2655472..2656770 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2655793..2655812) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2655816) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2655827..2655833) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2656757 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2656810..2657967) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2656810..2657967) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2656835) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2657083..2657088 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2657103..2657121 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2657111 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2657964..2658674) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2657964..2658674) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2658688..2658703) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2658705) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2658715..2658724) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2658731..2658732 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2658744..2658849 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2658744 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2658752..2658762 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2658815..2658821 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2658836..2658855 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2658851..2658964 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2658851 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2658965..2659186 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2658965..2659186 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2659169 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2659238 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2659307..2660026) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2659307..2660026) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2659321) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2660092) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2660095..2661729) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2660095..2661729) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2661761..2661780) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2661777) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2661847..2661851 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2661867..2661886 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2661885 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2661931..2663193 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2661931..2663193 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2663194..2663292 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2663266..2663272 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2663288..2663306 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2663294..2663381 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2663294 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2663382..2664920 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2663382..2664920 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2664900 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2664957..2665139) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2664957..2665139) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2664976) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2665154..2665172) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2665174) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2665188..2665193) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2665207..2665875) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2665207..2665875) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2665897..2667183) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2665897..2667183) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2667195..2667698) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2667195..2667698) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2667695..2668816) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2667695..2668816) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2668824..2669789) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2668824..2669789) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2669815) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2669816..2669835) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2669850..2669857) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2669945..2669952 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2669965 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2669968..2669987 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2670005..2672323 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2670005..2672323 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2672313 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2672364..2673860) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2672364..2673860) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2672366) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2673885..2674745) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2673885..2674745) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2674821..2674840) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2674830) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2674856..2674863) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2674952..2675713) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2674952..2675713) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2674981) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2675714..2675789) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2675790..2676977) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2675790..2676977) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2677046..2678053) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2677046..2678053) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2678056..2678751) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2678056..2678751) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2678748..2679917) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2678748..2679917) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2678784..2678791 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2678806..2678825 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2678824 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2679907..2681253) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2679907..2681253) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2680323..2680327 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2680342 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2680343..2680361 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2681243..2682019) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2681243..2682019) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2682020..2682112) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2682098..2682117) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682112) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2682132..2682139) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2682229..2683128) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2682229..2683128) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2683151..2683169) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2683168) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2683180..2683188) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2683258..2683265 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2683281..2683300 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2683287 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2683346..2684380 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2683346..2684380 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2684329..2684336 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2684351..2684359 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2684368 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2684414..2685694 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2684414..2685694 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2685687..2686598 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2685687..2686598 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2686595..2687425 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2686595..2687425 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2687398..2687402 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2687418..2687437 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2687426 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2687445..2688743 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2687445..2688743 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2688724 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2688765..2689076) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2688765..2689076) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2688776) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2689100..2689119) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2689108) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2689134..2689141) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2689142 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2689193..2691607) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2689193..2691607) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2689197) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2691608..2691703) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2691717..2691931) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2691717..2691931) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2691748) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2691943..2691962) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2691964) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2691968..2691973 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2691977..2691982) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2691989..2692007 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2692002..2692442 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2692002 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2692034..2692369) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2692034..2692369) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2692364..2692628) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2692613..2692632) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2692628) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2692647..2692654) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2692667..2692674 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2692688..2692707 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2692704 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2692706..2692773 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2692774..2693559 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2692774..2693559 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2693560..2693616 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2693796..2694989) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2693796..2694989) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2693816) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2694990..2695088) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2695069..2695088) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2695088) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2695102..2695109) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2695126..2695129 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2695144..2695163 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2695148 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2695178..2695924 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2695178..2695924 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2695819 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2695918 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2695961..2697901) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2695961..2697901) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2695972) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2697891..2698652) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2697891..2698652) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2698676..2698694) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2698695) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2698754..2699758) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2698754..2699758) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2698793) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2699751..2700446) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2699751..2700446) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2700470..2700488) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2700482) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2700504..2700507) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2700543..2701853) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2700543..2701853) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2700565) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2701843..2702538) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2701843..2702538) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2702553..2703530) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2702553..2703530) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2703560..2704546) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2703560..2704546) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2704416..2704425 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2704432 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2704438..2704453 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2704540..2705418) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2704540..2705418) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2705411..2705803) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2705411..2705803) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2705804..2706048) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2705837..2705974) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2705837..2705974) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2705972 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2706043..2706062) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2706048) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2706076..2706083) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2706129..2706401) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2706129..2706401) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2706136) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2706441..2706452) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2706445..2706453 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2706445) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2706456 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2706467..2706473) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2706467..2706485 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2706496..2706501 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2706515..2706534 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2706522 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2706563..2707531 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2706563..2707531 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2707528..2708112 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2707528..2708112 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2708076 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2708102..2709205) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /translation="MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQ ATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDF RMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLL ELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVA YSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMM DRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASG KTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC*" /label="tbcS CDS" gene complement(2708102..2709205) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /label="tbcS gene" downshifts complement(2708143) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2709226..2710005) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /EC_number="3.1.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11796336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11796336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospholipase component of bacilysocin synthesisor export" /protein_id="NP_390929.1" /db_xref="EnsemblGenomes-Gn:BSU30510" /db_xref="EnsemblGenomes-Tr:CAB15029" /db_xref="GOA:O34705" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13900" /db_xref="UniProtKB/Swiss-Prot:O34705" /translation="MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGD LPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQR NPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEA DQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWF NGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI*" /label="ytpA CDS" gene complement(2709226..2710005) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /label="ytpA gene" promotor_-35 2709648..2709655 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2709670..2709689 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2709687 /Source="Nicolas_upshifts" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2710006..2710585) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" CDS 2710054..2710569 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22868757; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of the carbonic anhydrase family" /protein_id="NP_390930.1" /db_xref="EnsemblGenomes-Gn:BSU30520" /db_xref="EnsemblGenomes-Tr:CAB15030" /db_xref="GOA:O34696" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG13896" /db_xref="UniProtKB/Swiss-Prot:O34696" /translation="MIYPYKEHKPDIHPTAFIADNATITGDVVIGEQSSIWFSVVIRG DVAPTRIGNRVNIQDLSCLHQSPNKTLLIEDDATIGHQVTLHSAVIRKNALIGMGSII LDGAEIGEGAFIGAGSLVPPGKIIPPGHLAFGRPAKVIRPLTEEDRKDMQRIRSEYVE KGQYYKFLQQT*" /label="ytoA CDS" gene 2710054..2710569 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /label="ytoA gene" promotor_-10 complement(2710576..2710595) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2710585) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2710587..2710721) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2710607..2710614) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2710696..2710715) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2710721) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2710814..2712205) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2710814..2712205) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2710822) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2712206..2712340) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2712341..2714239) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2712341..2714239) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2713397..2713403 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2713418..2713429 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2713430 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2714240..2714363) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2714389..2715591) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2714389..2715591) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2714408) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2715634..2715645) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2715640) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2715642..2715758) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2715659..2715665) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2715759..2715897) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2715759..2715897) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2715857 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2715906..2715925) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2715921) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2715942..2715946) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2716018..2716025 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2716037 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2716039..2716058 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2716094..2717677 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2716094..2717677 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2717666 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2717716..2717958) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2717716..2717958) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2717730) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2718010..2718783) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2718010..2718783) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2718784..2718874) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2718850..2718859 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2718863..2718882) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2718871 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2718872..2718891 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718876) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2718897..2718904) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2718934..2719938 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2718934..2719938 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2719951..2720733 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2719951..2720733 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2719955..2721503) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2720708..2721520 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2720708..2721520 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2721505 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2721547..2722023) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2721547..2722023) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2721548) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2722053..2722072) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2722066) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2722068..2722202) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2722202) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2722204..2722215) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2722230..2722236) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2722232..2722636) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2722232..2722636) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2722664..2722683) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722681) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2722683..2722769) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2722696..2722705) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2722802..2723239) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2722802..2723239) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2722814) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2723256..2723274) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2723274) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2723276..2723501) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2723289..2723295) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2723331..2723350 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2723332..2723508 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2723332..2723508 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2723333 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2723502..2723939) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2723502..2723939) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2723528 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2723958..2723977) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2723979) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2723988..2723996) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2724059..2724532) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2724059..2724532) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2724068) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2724155) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2724533..2724884) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2724604..2724611 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2724624..2724643 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2724629 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2724661..2724888 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2724661..2724888 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2724885..2725448) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2724885..2725448) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2725473..2725492) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2725488) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2725542..2725790) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2725542..2725790) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2725563) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2725818..2725837) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2725851..2725858) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2725855) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2725917..2725923 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2725937..2725948 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2725949 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2725995..2727326 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2725995..2727326 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2727370..2728410 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2727370..2728410 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2728404..2728410 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2728425..2728436 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2728435 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2728464..2728622 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2728464..2728622 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2728611 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2728641..2729528) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2728641..2729528) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2728664) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2729518..2730825) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2729518..2730825) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2730831..2731583) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2730831..2731583) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2731602..2732522) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2731602..2732522) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2732558..2732569) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2732559) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2732561..2732652) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2732583..2732589) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2732637 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2732638..2732657) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2732640..2732652 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2732652) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2732654..2732735) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2732672..2732679) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2732735) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2732744..2732763) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2732777..2732784) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2732802..2733917) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2732802..2733917) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2732845) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2733914..2735374) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2733914..2735374) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2734817..2734835) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2734821) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2734850..2734856) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2735463) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2735465..2736280) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2735465..2736280) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2736315..2737139) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2736315..2737139) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2736397..2736416) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2736397) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2736432..2736435) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2736563) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2736573..2736584) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2736599..2736605) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2737127..2738869) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2737127..2738869) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2738866..2740281) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2738866..2740281) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2740282..2740394) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2740374..2740393) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2740394) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2740396..2740546) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2740409..2740412) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2740507..2740513 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2740527..2740546) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2740527..2740538 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2740535 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2740546) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2740560..2740569) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2740571..2741290 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2740571..2741290 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2740641..2741298) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2741279 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2741299..2742117) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2741299..2742117) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2742138..2742157) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2742152) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2742172..2742180) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2742218..2742226 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2742239..2742258 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2742240 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2742289..2743575 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2742289..2743575 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2743572..2744522 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2743572..2744522 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2744525..2745748 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2744525..2745748 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2745672) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2745749..2746316 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2745822..2746253) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2745822..2746253) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2745848) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2746255..2747310) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2746255..2747310) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2747325..2748458) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2747325..2748458) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2748491..2748510) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2748510) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2748523..2748532) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2748596..2748605 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2748619..2748638 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2748621 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2748648..2749721 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2748648..2749721 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2748945..2748951 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2748962 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2748965..2748976 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2749710 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2749748..2749754 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2749769 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2749770..2749788 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2749801..2750268 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2749801..2750268 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2750240 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2750299..2752695) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2750299..2752695) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2750314) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2752682..2754136) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2752682..2754136) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2754133..2755164) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2754133..2755164) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2755188..2756330) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2755188..2756330) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2756327..2758210) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2756327..2758210) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2757036..2758455 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2758242..2758257) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2758255) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2758272..2758277) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2758322) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2758443..2758514) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2758443..2758514) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2758540..2758630) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2758540..2758630) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2758634..2758708) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2758634..2758708) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2758719..2758795) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2758719..2758795) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2758811..2758884) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2758811..2758884) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2758895..2758970) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2758895..2758970) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2758988..2759063) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2758988..2759063) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2759076..2759152) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2759076..2759152) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2759164..2759240) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2759164..2759240) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2759258..2759350) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2759258..2759350) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2759357..2759433) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2759357..2759433) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2759436..2759512) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2759436..2759512) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2759532..2759604) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2759532..2759604) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2759610..2759686) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2759610..2759686) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2759702..2759778) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2759702..2759778) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2759788..2759873) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2759788..2759873) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2759888..2759962) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2759888..2759962) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2759968..2760054) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2759968..2760054) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2760065..2760140) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2760065..2760140) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2760178..2760253) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2760178..2760253) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2760286..2760361) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2760286..2760361) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2760382..2760499) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2760382..2760499) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2760555..2763482) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2760555..2763482) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2763650..2765204) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2763650..2765204) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2765006,2765008) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2765205..2765496) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2765332..2765340 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2765338 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2765448 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2765469..2765488) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2765496) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2765498..2766464) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2765502..2765509) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2765621..2765624 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2765636 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2765639..2765658 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2765669..2765770 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2765669..2765770 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2765769 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2765870..2766448 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2765870..2766448 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2766438 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2766490..2767011) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2766490..2767011) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2766508) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2766580) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2767029..2768558) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2767029..2768558) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2768579..2769103) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2768579..2769103) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2769147..2769162) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2769153) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2769155..2769242) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2769174..2769183) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2769227..2769245) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2769237 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2769241..2769260 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2769242) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2769260..2769265) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2769271..2769759 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2769271..2769759 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2769736 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2769765..2770343) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2769765..2770343) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2769781..2770172 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2769792) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2770377..2770396) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2770386) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2770410..2770417) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2770431..2771639) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2770431..2771639) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2770452) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2771408..2771427) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2771420) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2771442..2771449) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2771656..2773128) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2771656..2773128) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2773179..2773198) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2773180) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2773213..2773220) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2773240..2773246 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2773260..2773279 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2773275 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2773327..2773869 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2773327..2773869 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2773852 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2773946..2773953 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2773966..2774066 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2773966 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2773968..2773987 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2774067..2774612 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2774067..2774612 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2774599 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2774704..2774711 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2774725..2774744 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2774732 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2774737..2774905 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2774737..2774905 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2774886 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2774978..2775646 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2774978..2775646 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2775653..2776990 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2775653..2776990 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2776976 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2777026..2777289) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2777026..2777289) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2777044) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2777329..2777348) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2777331) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2777361..2777368) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2777398..2778246) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2777398..2778246) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2778291..2778310) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2778301) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2778325..2778332) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2778407..2779942) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2778407..2779942) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2778416) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2779600..2779700 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2779660 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2779726 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2779943..2780110) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2780099..2780118) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2780110) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2780112..2780989) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2780133..2780140) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2780352..2780361 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2780375..2780394 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2780375 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2780427..2780912 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2780427..2780912 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2780913..2781199 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2781019..2781091) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2781019..2781091) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2781034) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2781078) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2781102..2781121) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2781122) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2781136..2781139) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2781156 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2781199..2782029) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2781199..2782029) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2781210) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2782030..2782121) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2782122..2783288) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2782122..2783288) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2783284..2783288 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2783296..2783310 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2783312..2783331) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2783312 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2783331) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2783345..2783352) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2783410..2783417 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2783423 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2783428..2783447 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2783470..2784456 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2783470..2784456 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2784427 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2784497..2785771) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2784497..2785771) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2784510) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2785797..2786111) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2785797..2786111) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2786129..2787586) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2786129..2787586) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2787591..2788367) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2787591..2788367) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2788401..2788420) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2788417) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2788424..2790493) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2788424..2790493) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2790526..2790545) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2790538) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2790559..2790565) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2790631..2792619) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2790631..2792619) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2790650) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2792623..2792630 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2792640..2792658) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2792646..2792665 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2792653) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2792662 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2792672..2792679) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2792728 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2792733..2794718) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2792733..2794718) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2792738) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2794739..2794757) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2794754) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2794756..2794843) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2794771..2794778) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2794844..2796832) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2794844..2796832) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2796857..2796875) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2796872) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2796889..2796896) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2797009..2798997) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2797009..2798997) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2797028) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2799018..2799036) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2799039) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2799049..2799056) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2799099..2799108 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2799122..2799141 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2799125 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2799155..2799892 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2799155..2799892 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2799180..2799199) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2799188) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2799215..2799219) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2799893..2802713 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2799906..2800160) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2799906..2800160) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2799932) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2800161..2800417) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2800418..2800816) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2800418..2800816) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2800776..2800910) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2800776..2800910) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2800859..2800878) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2800866) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2800893..2800899) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2800936..2802600) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2800936..2802600) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2800952) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2801908..2801927) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801913) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2801941..2801948) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2802625..2802643) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2802642) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2802659..2802664) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2802727..2804016) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2802727..2804016) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2802736) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2803545..2803551 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2803565..2803583 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2803571 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2803575..2804227 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2804060..2804737) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2804060..2804737) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2804070) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2804412..2805088 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2804772..2804791) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2804779..2805042) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2804779..2805042) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2804793) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2804805..2804812) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2805054..2805072) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2805068) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2805088..2805093) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2805089..2805421 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2805089..2805421 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2805106..2805112 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2805127..2805144 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2805138 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2805418..2806404 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2805418..2806404 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2806379) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2806401..2806805) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2806401..2806805) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2806806..2806864) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2806865..2807236) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2806865..2807236) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2807295..2808647) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2807295..2808647) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2807306) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2807462..2807480) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2807479) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2807496..2807501) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2808620) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2808623..2808634) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2808679..2808698) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2808685) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2808687..2808758) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2808713..2808716) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2808759..2809931) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2808759..2809931) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2809094..2810015 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2809964..2809983) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2809977) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2810000..2810003) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2810035..2811198) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2810035..2811198) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2810050) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2811213..2811232) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2811231) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2811233..2811388) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2811247..2811254) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2811284..2811290 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2811305..2811323 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2811315 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2811316..2811374 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2811361..2811367 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2811363..2811374) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2811376 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2811381..2811392 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2811388..2811394) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2811388) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2811390..2811701) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2811428..2811664 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2811428..2811664 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2811624 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2811690 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2811742..2812134) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2811742..2812134) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2811746) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2812176..2812195) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2812183) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2812185..2812335) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2812211..2812215) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2812238..2812244 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2812251..2813235 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2812251 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2812259..2812277 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2812336..2813496) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2812336..2813496) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2813388..2813394 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2813406 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2813408..2813412 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2813497..2813997) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2813497..2813997) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2814027..2814046) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2814033..2814039 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2814048) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2814054..2814065 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2814054 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2814057..2814064) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2814066..2814144 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2814145..2814966 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2814145..2814966 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2814946 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2814993) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2814995..2815255) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2814995..2815255) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2815245..2815248 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2815263..2815282 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2815275 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2815276..2815341 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2815281..2815300) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2815286) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2815312..2815318) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2815342..2816505 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2815342..2816505 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2816568..2816574 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2816586..2816605 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2816596 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2816631..2817917 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2816631..2817917 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2817633..2818375) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2817912..2817919 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2817933..2817952 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2817934 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2817963..2818349 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2817963..2818349 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2818331 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2818376..2818993) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2818376..2818993) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2819028..2819046) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2819045) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2819047..2821135) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2819061..2819066) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2819109..2819112 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2819127..2819146 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2819138 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2819204..2820382 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2819204..2820382 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2820420..2820426 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2820438..2820457 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2820443 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2820475..2822349 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2820475..2822349 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2821115..2821134) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2821135) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2821148..2821157) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2822370..2822783 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2822370..2822783 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2822775 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2822986..2823543) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2822986..2823543) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2823007..2823026 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2823017 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2823027) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2823039..2823720 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2823569..2823588) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2823577) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2823604..2823608) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2823721..2825322 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2823721..2825322 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2825315..2826022 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2825315..2826022 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2826007 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2826186..2826193 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2826204..2826493 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2826204 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2826208..2826227 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2826494..2827573 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2826494..2827573 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2827649..2829181 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2827649..2829181 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2829174..2830220 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2829174..2830220 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2830221..2831180 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2830221..2831180 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2831181..2831302 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2831275..2831278 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2831293..2831312 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2831304 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2831334..2832680 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2831334..2832680 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2832663 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2832716..2832931) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2832716..2832931) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2832871..2832877 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2832891..2832902 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2832895 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2832942..2832960) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2832949) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2832974..2832981 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2832976..2832981) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2832996..2833091 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2832996..2833015 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2832996 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2833054..2833058 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2833074..2833093 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2833093..2833242 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2833093 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2833162..2835567 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2833162..2835567 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2835560..2835991 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2835560..2835991 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2835991..2836332 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2835991..2836332 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2836223..2836323 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2836283 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2836325..2837806 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2836325..2837806 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2837058..2838926) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2837812..2838288 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2837812..2838288 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2838288..2838572 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2838288..2838572 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2838556..2838930 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2838556..2838930 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2838901 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2838969..2839349) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2838969..2839349) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2838971) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2839368..2840012) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2839368..2840012) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2840013..2840092) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2840093..2842402) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2840093..2842402) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2841087..2841094 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2841108..2841127 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2841123 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2841996..2842967 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2841996 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2842008..2842024 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2842417..2842584) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2842417..2842584) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2842572..2843470) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2842572..2843470) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2843471..2843584) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2843578..2843597) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843584) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2843611..2843617) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2843655..2843795) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2843655..2843795) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2843684) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2843796..2843882) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2843866..2843885) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843882) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2843899..2843905) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2843982..2844000) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843992) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2844015..2844021) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2844017..2844142 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2844017..2844142 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2844170..2844599) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2844195..2844200 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2844212) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2844215..2844233 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2844217 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2844256..2844624 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2844256..2844624 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2844600..2845829) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2844600..2845829) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2844625..2845938 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2845864..2845883) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845883) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2845896 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2845898..2845905) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2845966..2847438) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2845966..2847438) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2845976) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2847319..2847323 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2847326 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2847436 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2847454..2848005) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2847454..2848005) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2848027..2848046) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2848040) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2848059..2848066) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2848102..2848500) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2848102..2848500) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2848501..2848571) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2848572..2848820) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2848572..2848820) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2848843..2848862) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2848854) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2848878..2848881) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2848893..2849114) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2848893..2849114) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2848920) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2849108 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2849132..2849151) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2849138) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2849164..2849173) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2849174..2850283) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2849174..2850283) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2849935..2849942 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2849957..2849976 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2849966..2850360 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2849966 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2850331..2850350) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2850347) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2850349..2850789) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2850352..2850354 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2850362 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2850364..2850369) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2850370..2850389 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2850398..2850787 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2850398..2850787 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2850828..2851064) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2850828..2851064) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2850834) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2851084..2851103) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2851098) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2851100..2851240) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2851117..2851126) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2851241..2851771) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2851241..2851771) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2851791..2851810) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2851802) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2851804..2851890) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2851822..2851830) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2851885..2851904) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2851892) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2851918..2851927) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2851969..2852700) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2851969..2852700) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2851999) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2852715..2852734) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2852726) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2852749..2852756) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2852763..2853218) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2852763..2853218) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2853171..2853177 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2853192..2853210 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2853200..2855567 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2853200 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2853250..2856480) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2853250..2856480) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2856477..2860964) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2856477..2860964) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2860239..2860245 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2860260..2860278 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2860266..2861228 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2860266 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2861025..2862380) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2861025..2862380) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2861046) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2862395..2862634) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2862395..2862634) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2862704..2862997) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2862704..2862997) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2862714) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2862991 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2862998..2863076) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2863039..2863046 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2863056..2863075) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2863057 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2863061..2863078 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2863076) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2863090..2863097) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2863135..2863140 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2863155..2863174 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2863167..2863273 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2863167 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2863342..2863348 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2863362..2863381 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2863365 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2863470..2863473 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2863482 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2863485..2863504) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2863489..2863508 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2863507) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2863518..2864786 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2863518..2864786 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2863519..2863526) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2864846..2864865 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2864851 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2864888..2866024 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2864888..2866024 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2866024 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2866073..2866081 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2866091 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2866093..2866111 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2866136..2866813 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2866136..2866813 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2866797 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2866857..2867066) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2866857..2867066) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2866869) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2867082..2874218) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2867082..2874218) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2874238..2875176) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2874238..2875176) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2875204..2876823) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2875204..2876823) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2876852..2878048) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2876852..2878048) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2877896..2877903 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2877918..2877937 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2877925 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2878074..2878859) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2878074..2878859) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2878860..2878969) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2878964..2878983) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2878969) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2878971..2879052) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2878997..2879004) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2879053..2879922) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2879053..2879922) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2879923..2880003) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2879987..2880006) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2880003) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2880020..2880027) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2880136..2880732) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2880136..2880732) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2880733..2880817) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2880768..2880775 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2880785 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2880790..2880809 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2880811..2880825) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2880817) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2880833..2880837) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2880833..2881435 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2880833..2881435 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2881421 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2881505..2882833) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2881505..2882833) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2881521) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2882887..2882906) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2882890) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2882921..2882928) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2882980..2884482) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2882980..2884482) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2882995) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2884047..2884061 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2884063 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2884483..2884557) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2884505..2884512 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2884523..2884542 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2884525..2884639 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2884525 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2884552..2884571) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2884562) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2884640..2885116 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2884640..2885116 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2885065 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2885147..2885803) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2885147..2885803) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2885175) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2885451..2885460 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2885474..2885493 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2885491 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2885493..2885939 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2885817) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2885819..2885830) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2885845..2885851) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2885896 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2885907..2886227) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2885907..2886227) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2885921) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2885941..2886151 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2886093..2886193 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2886153..2886262 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2886153 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2886219 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2886246..2886265) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2886251) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2886264..2886815 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2886280..2886287) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2886281..2886424) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2886281..2886424) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2886448..2886467) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2886469) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2886483..2886486) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2886597..2887817) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2886597..2887817) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2886625) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2887818..2887945) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2887945) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2887947..2888011) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2887947..2887965) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2887981..2887986) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2888002..2888021) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2888010) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2888036..2888043) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2888085..2888092 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2888104..2888123 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2888104 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2888149..2889147 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2888149..2889147 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2888172..2888190) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2888187) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2888207..2888212) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2889123 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2889186..2889326) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2889186..2889326) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2889198) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2889327..2889456) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2889437..2889456) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2889456) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2889458..2889705) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2889470..2889476) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2889513..2889520 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2889534..2889553 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2889542 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2889605..2890585 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2889605..2890585 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2889706) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2889710..2889721) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2889735..2889741) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2890553 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2890658) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2890659..2891282) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2890659..2891282) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2891306..2891824) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2891306..2891824) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2891871..2891890) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2891883) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2891885..2891993) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2891980..2891997) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2891991) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2892012..2892019) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2892147) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2892162..2892524) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2892162..2892524) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2892555..2892574) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892565) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2892588..2892595) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2892603..2893457) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2892603..2893457) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2893173..2893192) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2893181) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2893205..2893214) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2893479..2893498) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2893493) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2893513..2893516) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2893580..2894794) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2893580..2894794) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2894129..2894135 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2894150..2894168 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2894157 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2894161..2894930 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2894831..2894850) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2894836) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2894865..2894872) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2894887 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2894931..2895167) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2894931..2895167) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2894932..2895348 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2894949) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2895132..2895133) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2895137..2895141) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2895139) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2895182..2895201) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2895183) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2895215..2895222) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2895325..2895330 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2895344..2895363 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2895350 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2895430..2896497 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2895430..2896497 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2896481 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2896523..2896849) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2896523..2896849) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2896546) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2896881..2896900) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2896898) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2896913..2896920) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2896933..2896937 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2896949..2897284 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2896949..2897284 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2896950..2896969 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2896955 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2897074) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2897262 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2897326..2899299) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2897326..2899299) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2897338) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2899314..2899332) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2899337) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2899344..2899352) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2899407..2900336) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2899407..2900336) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2899420) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2900333..2901391) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2900333..2901391) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2901391..2902692) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2901391..2902692) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2902577..2902586 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2902601..2902620 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2902608 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2902693..2902774) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2902759..2902778) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2902774) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2902776..2902892) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2902793..2902800) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2902893..2903912) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2902893..2903912) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2903720..2903725 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2903741..2903759 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2903745 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2903935..2903953) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2903942) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2903951..2903956 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2903969..2903974) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2903972..2904036 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2903972..2903990 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2903972 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2904009..2904018 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2904031..2904050 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2904038 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2904065..2904565 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2904065..2904565 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2904592..2905362) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2904592..2905362) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2904620) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2905391..2905825) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2905391..2905825) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2905849..2906124) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2905849..2906124) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2906144..2906163) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2906169) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2906171..2906863) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2906177..2906184) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2906187..2906193 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2906208..2906219 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2906216 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2906239..2906871 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2906239..2906871 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2906832 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2906887..2907783) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2906887..2907783) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2906908) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2907784..2907918) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2907905..2907924) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2907918) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2907940..2907944) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2907958..2907964 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2907978..2907989 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2907990 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2908018..2908998 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2908018..2908998 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2908096) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2908110..2908129) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2908146..2908149) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2908990 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2909026..2909790) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2909026..2909790) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2909042) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2909804..2909822) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2909812) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2909838..2909843) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2909863..2910168) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2909863..2910168) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2909871) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2910182..2910201) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2910205) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2910215..2910223) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2910233..2911621) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2910233..2911621) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2911641..2912462) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2911641..2912462) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2912480..2913328) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2912480..2913328) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2912847..2912852 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2912868..2912886 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2912882 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2913339..2913358) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2913354) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2913366..2913713) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2913366..2913713) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2913726..2913745) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2913745) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2913759..2913765) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2913810..2915150) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2913810..2915150) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2913838) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2914894) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2915207..2915213 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2915227..2915246 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2915229..2915247) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2915235 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2915236..2915324 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2915246) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2915263..2915268) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2915325..2916920 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2915325..2916920 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2917065..2918414 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2917065..2918414 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2918420..2919712 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2918420..2919712 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2919725..2921209 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2919725..2921209 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2921209..2921553 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2921209..2921553 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2921275..2921278 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2921296..2921315 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2921308 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2921528 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2921569..2921956) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2921916..2921925 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2921938..2921957 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2921941 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2921977..2922108) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2921977..2922108 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2921977..2922108 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2921977..2922108) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2922109..2922177 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2922144 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2922314..2922835) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2922314..2922835) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2922826..2925063) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2922826..2925063) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2925064..2925897) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2925064..2925897) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2925894..2926511) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2925894..2926511) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2926003) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2926508..2927500) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2926508..2927500) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2927501..2927587) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2927565..2927584) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2927587) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2927598..2927603) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2927729..2928979) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2927729..2928979) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2928996..2930234) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2928996..2930234) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2930457..2930594 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2930457..2930594 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2930616..2930619 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2930634..2930653 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2930635 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2930676..2931542 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2930676..2931542 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2931545 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2931576..2932679) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2931576..2932679) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2931591) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2932680..2933613) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2932717..2932724 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2932738..2932757 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2932748 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2932799..2932805 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2932816 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2932820..2932839 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2932861..2933589 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2932861..2933589 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2933614..2934468) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2933614..2934468) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2933801..2933820) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2933813) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2933971..2934071) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2934011) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2934482..2935384) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2934482..2935384) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2935388..2936266) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2935388..2936266) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2936324..2937592) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2936324..2937592) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2937483..2937583 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2937543 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2937663) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2937673..2938659) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2937673..2938659) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2938606 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2938609..2938613 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2938702..2938721) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2938715) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2938736..2938743) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2938873) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2938875..2939249) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2938875..2939249) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2939313) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2939320..2939331) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2939345..2939351) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2939352..2940470) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2939352..2940470) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2940495..2940514) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940501) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2940503..2941113) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2940528..2940534) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2940567..2940576 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940590..2940609 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940594 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2940607..2940622) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940611) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2940629..2940633) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2940629..2940775 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2940629..2940775 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2940775..2941050 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2940775..2941050 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2940919) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2940935..2940949) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2940958..2940962) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2941030 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2941114..2941497) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2941114..2941497) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2941498..2941607) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2941608..2941886) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2941608..2941886) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2941884..2941903) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2941908) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2941918..2941925) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2942049..2942155) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2942092) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2942156..2943553) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2942156..2943553) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2943351 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2943574..2944017) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2943574..2944017) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2944007..2945227) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2944007..2945227) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2945227..2946540) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2945227..2946540) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2946558..2947343) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2946558..2947343) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2947387..2947406) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2947388) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2947420..2947427) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2947444..2947463) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2947453) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2947455..2947536) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2947479..2947483) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2947500..2947747) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2947500..2947747) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2947537..2947674) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2947537..2947674) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2947675..2947759) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2947743..2947762) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2947759) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2947761..2947867) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2947778..2947781) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2947868..2948245) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2947868..2948245) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2948262..2948273) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2948268) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2948287..2948293) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2948330..2949154) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2948330..2949154) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2948338) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2948487) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2948514..2948519 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2948535..2948553 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2948537 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2949168..2949836) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2949168..2949836) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2949829..2950854) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2949829..2950854) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2950855..2950959) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2950960..2951066) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2950960..2951066) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2951029 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2951093..2951112) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2951105) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2951107..2951180) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2951128..2951135) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2951181..2951525) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2951181..2951525) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2951526..2951631) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2951632..2951952) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2951632..2951952) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2951954..2952394) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2951954..2952394) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2952394..2952630) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2952394..2952630) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2952406) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2952645) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2952650..2952661) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2952676..2952682) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2952686..2953069) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2952686..2953069) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2953096..2953115) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2953107) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2953128..2953135) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2953136..2953492) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2953136..2953492) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2953515..2953534) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2953525) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2953548..2953553) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2953603..2955387) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2953603..2955387) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2953613) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2955402..2956577) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2955402..2956577) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2956588..2958957) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2956588..2958957) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2958376..2958381 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2958396..2958414 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2958399 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2959025..2959044) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2959028) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2959036..2959302) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2959058..2959065) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2959083..2959089 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959104..2959115 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959126 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2959132..2959278 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2959132..2959278 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2959279..2960305 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2959303..2960211) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2959303..2960211) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2960212..2960734) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2960306..2960551 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2960306..2960551 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2960564..2960896 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2960564..2960896 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2960717..2960736) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2960734) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2960750..2960759) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2960885 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2960957..2960964 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2960978..2960997 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2960989 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2961055..2961522 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2961055..2961522 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2961519..2963144 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2961519..2963144 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2963129 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2963180..2963563) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2963180..2963563) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2963582..2963971) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2963582..2963971) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2963993..2964322) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2963993..2964322) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2964357..2964376) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2964364..2964371 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2964371) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2964386..2964405 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2964390..2964397) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2964396 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2964456..2965343 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2964456..2965343 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2965363..2965650) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2965363..2965650) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2965375) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2965675..2966502) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2965675..2966502) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2965691) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2966503..2966640) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2966625..2966644) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2966640) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2966660..2966663) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2966720..2967157) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2966720..2967157) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2967181..2967199) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2967187) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2967215..2967220) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2967267..2968775) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2967267..2968775) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2967288) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2968766..2969062) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2968766..2969062) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2969085..2969104) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2969101) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2969119..2969122) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2969139..2969144 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2969156..2969175 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2969156 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2969196..2970038 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2969196..2970038 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2969568..2969574 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2969589..2969600 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2969597 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2970065..2970072 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2970081 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2970084..2970103 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2970128..2970589 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2970128..2970589 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2970565 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2970633..2972009) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2970633..2972009) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2970641) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2972010..2972181) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2972162..2972181) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2972181) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2972192..2972199) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2972242..2972261) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2972252..2972271 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2972254 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2972260) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2972262..2973325) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2972276..2972283) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2972287..2972964 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2972287..2972964 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2972961..2974316 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2972961..2974316 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2973415..2974343) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2974284 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2974344..2974508) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2974344..2974508) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2974532..2974539 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2974553..2974572 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2974557..2974576) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2974563..2974675 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2974563 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2974570) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2974572..2974850) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2974590..2974597) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2974676..2975551 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2974676..2975551 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2974840..2974859) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974850) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2974852..2975393) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2974873..2974880) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2975385..2975403) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2975393) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2975395..2975524) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2975416..2975423) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2975526 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2975569) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2975587..2976975) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2975587..2976975) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2976999) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2977004..2977022) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2977033..2977041) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2977042..2977227) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2977042..2977227) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2977231 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2977271..2977290) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2977280..2977286 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2977285) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2977300..2977311 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2977303 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2977306..2977309) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2977345..2978793 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2977345..2978793 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2978341..2980984) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2978762..2979859 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2978762..2979859 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2979856..2980977 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2979856..2980977 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2980985..2981620) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2980985..2981620) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2981598..2982680) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2981598..2982680) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2982677..2983402) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2982677..2983402) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2983436..2984308) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2983436..2984308) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2984327..2984346) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2984347) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2984361..2984364) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2984409..2985086) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2984409..2985086) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2984425) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2985113..2985493) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2985113..2985493) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2985516..2985535) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2985536) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2985550..2985553) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2985655..2986923) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2985655..2986923) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2985668) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2986957..2986976) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2986968) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2986991..2986998) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2987094) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2987100..2987681) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2987100..2987681) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2987704..2989032) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2987704..2989032) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2989032..2990093) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2989032..2990093) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2990056..2991000) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2990056..2991000) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2991001..2991270) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2991109..2991239) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2991109..2991239) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2991247..2991266) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2991270) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2991272..2992199) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2991282..2991289) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2991332..2991339 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2991354..2991373 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2991358 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2991398..2992189 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2991398..2992189 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2992060 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2992170 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2992227..2993105) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2992227..2993105) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2992244) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2993129..2993147) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2993148) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2993161..2993167) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2993177..2994919) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2993177..2994919) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2994916..2995629) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2994916..2995629) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2995660..2995679) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2995678) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2995782..2996021) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2995782..2996021) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2995789) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2996017..2996035) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2996025..2996555) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2996025..2996555) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2996026) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2996050..2996056) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2996558..2996577) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2996565) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2996570..2996908 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2996570..2996908 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2996592..2996599) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2996608..2996627) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2996620) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2996642..2996648) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2996654..2996754 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2996714 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2996882..2996982 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2996942..2997028 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2996942 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2997029..2998186 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2997029..2998186 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2998172 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2998247..2998657 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2998247..2998657 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2998656 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2998691..2999920) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2998691..2999920) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2998708) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2999913..3000602) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2999913..3000602) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(3000586..3001779) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(3000586..3001779) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(3001823..3001842) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3001836) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3001857..3001864) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3001950..3002759) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(3001950..3002759) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(3001967) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3002106..3002115 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3002128..3002147 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3002132 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3002775..3003785) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(3002775..3003785) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(3003785..3004939) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(3003785..3004939) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(3004872..3004891) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3004889) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3004903..3004910) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3004951..3004958 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3004973..3004992 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3004982 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 3005037..3005984 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 3005037..3005984 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 3005960 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 3006004 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 3006158 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3006219..3007628) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(3006219..3007628) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(3006234) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3007046..3007050 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3007068..3007084 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3007075 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 3007082..3008049 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(3007730) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3007732..3007911) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(3007732..3007911) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(3007941..3007958) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3007952) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3007973..3007980) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3008006 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3008028..3008168) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(3008028..3008168) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(3008038) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(3008196) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(3008198..3008786) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(3008201..3008212) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(3008226..3008232) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 3008258..3008265 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3008279 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3008281..3008300 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3008335..3008817 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 3008335..3008817 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 3008831..3008838 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3008852..3008871 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3008864 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3008917..3010770 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 3008917..3010770 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 3010756 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3010798..3011724) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(3010798..3011724) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(3010810) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3011736..3011755) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3011757) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3011771..3011774) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3011793..3011812 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3011802 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 3011835..3012617 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 3011835..3012617 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 3012589..3013281 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 3012589..3013281 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 3013273 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(3013312..3014142) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(3013312..3014142) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(3013318) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 3014005..3014009 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3014025..3014029 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3014034 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3014144 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3014172..3014191) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3014190) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3014206..3014213) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3014298..3014304 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3014318 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3014319..3014337 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3014365..3014850 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 3014365..3014850 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 3014849 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(3014894..3016906) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(3014894..3016906) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(3014902) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3016572..3016576) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3016574) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3016907..3017058) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(3017035..3017053) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3017058) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3017161..3018876) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(3017161..3018876) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(3017168) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(3018902..3020719) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(3018902..3020719) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(3020761..3020780) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3020770..3020777 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3020780) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 3020783 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3020790..3020809 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3020793..3020800) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3020890..3023214) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(3020890..3023214) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(3020908) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3023234..3023241 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3023256..3023275 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(3023257..3023272) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3023260 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3023262) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3023307..3023326) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023316) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3023342..3023348) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3023352..3023371) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023372) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3023385..3023393) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3023399) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(3023412..3024020) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(3023412..3024020) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(3024059..3024078) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3024076) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3024094..3024098) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3024207..3024623) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(3024207..3024623) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(3024217) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(3024628..3025296) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(3024628..3025296) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(3025348..3025367) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025363) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3025374) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3025381..3025386) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3025416..3027524) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(3025416..3027524) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(3027516..3027617) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(3027611..3027630) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3027617) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3027646..3027653) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3027684..3030092) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(3027684..3030092) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(3027706) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3027772) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3030093..3030175) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(3030176..3030385) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(3030176..3030385) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(3030409..3030428) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(3030430) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(3030441..3030447) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(3030459..3030764) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(3030459..3030764) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 3030728..3030747 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3030739 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3030778..3030797) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(3030804) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(3030811..3030817) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 3030856..3030862 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3030877..3030895 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3030885 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 3030892..3031968 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 3030892..3031968 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 3031955 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(3032005..3032640) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(3032005..3032640) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(3032018) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3032641..3032738) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(3032718..3032737) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3032738) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3032751..3032757) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3032800..3034695) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(3032800..3034695) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(3034746..3034757) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3034746) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3034772..3034778) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3034845) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3034858..3035259) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(3034858..3035259) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(3035256..3035615) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(3035256..3035615) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(3035612..3036184) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(3035612..3036184) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(3036222..3036241) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3036227) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3036255..3036262) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3036295..3037089) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(3036295..3037089) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(3037110..3037128) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3037122) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3037143..3037149) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3037155..3037174) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3037166) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3037168..3037233) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(3037188..3037195) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(3037275..3037634) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(3037275..3037634) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(3037278) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3037618..3037626) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3037628) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3037641..3037646) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3037686..3037705) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3037694) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3037696..3037760) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(3037718..3037722) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3037760) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(3037761..3037780) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(3037795..3037802) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(3037811..3038281) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(3037811..3038281) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 3038108..3038208 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3038168 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3038278 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3038326..3038345) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3038332) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(3038334..3038425) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(3038361..3038364) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(3038426..3040765) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(3038426..3040765) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 3039526..3039529 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3039545..3039548 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3039554 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3040784..3041524) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(3040784..3041524) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(3041180..3041198) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(3041192) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(3041213..3041219) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(3041552..3041570) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3041566) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(3041654) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(3041656..3041886) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(3041656..3041886) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(3041916..3041935) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3041937) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(3041950..3041953) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 3041975..3041981 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3041995..3042006 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3041996 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 3042035..3042805 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 3042035..3042805 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 3042057..3042065 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3042076..3042094 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3042106 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3042845..3043078) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(3042845..3043078) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 3043169..3043176 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 3043184 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 3043188..3043207 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 3043230..3043637 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 3043230..3043637 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 3043667..3044086 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 3043667..3044086 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 3044124..3044131 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3044145..3044164 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3044152 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 3044178..3044504 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 3044178..3044504 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 3044505..3044589 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 3044560..3044567 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3044580..3044598 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3044591 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 3044629..3046329 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 3044629..3046329 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(3045345..3046338) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 3046307 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3046369..3047049) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(3046369..3047049) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(3046383) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3046743..3046749 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3046764..3046782 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3046769..3049520 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 3046769 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3047066..3047986) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(3047066..3047986) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(3047998..3048651) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(3047998..3048651) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(3048668..3049813) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(3048668..3049813) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(3049814..3049881) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(3049881) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3049882..3049901) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3049912..3049916 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3049916..3049919) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3049932..3049950 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3049937 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3050032..3050036 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3050052..3050071 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3050055 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 3050097..3050630 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 3050097..3050630 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(3050297..3050816) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 3050619 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3050753..3050760 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3050773..3050851 /Source="Nicolas_S_feature" /locus_tag="new_3464210_3464288" /HighExp="T-1.10H, T2.30H, T4.0H, T5.0H, T-2.40H, T2.0H, T-0.40H, M9-stat, T-5.40H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1293" upshifts 3050773 /Source="Nicolas_upshifts" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3050775..3050794 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3050801..3050815) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3050816) /Source="Nicolas_upshifts" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" CDS 3050852..3051328 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391255.1" /db_xref="EnsemblGenomes-Gn:BSU33750" /db_xref="EnsemblGenomes-Tr:CAB15380" /db_xref="GOA:O34889" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG14074" /db_xref="UniProtKB/Swiss-Prot:O34889" /translation="MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPT EENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCT NLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV*" /label="sdpA CDS" gene 3050852..3051328 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /label="sdpA gene" promotor_-10 complement(3050877..3050896) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3050887) /Source="Nicolas_upshifts" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3050908..3050915) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3051325..3052296 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16469701, 16850406, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16469701, 16850406, 17069462, 23687264; Product type t : transporter" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391256.1" /db_xref="EnsemblGenomes-Gn:BSU33760" /db_xref="EnsemblGenomes-Tr:CAB15381" /db_xref="GOA:O34616" /db_xref="InterPro:IPR007782" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG14075" /db_xref="UniProtKB/Swiss-Prot:O34616" /translation="MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDIL FSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWY ICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYI MTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNF IVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALI IYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS*" /label="sdpB CDS" gene 3051325..3052296 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /label="sdpB gene" promotor_no_box 3052133..3052233 /Source="Nicolas_upshift_promotors" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3052193 /Source="Nicolas_upshifts" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3052205..3052222) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3052226) /Source="Nicolas_upshifts" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3052228..3052630) /Source="Nicolas_S_feature" /locus_tag="new_3465665_3466067_c" /HighExp="Gly, Lbstat, BT, S8, T1.30H, C30, M9-stat, C90, Sw, HiTm" /AntisenseName="spbC" /AntisenseCor="-0.16053929530879699" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1294" promotor_-35 complement(3052239..3052241) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3052257) /Source="Nicolas_upshifts" /id="D1751" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="3.26001" /MaxDrop="4.09728" /score="-7.06061287" /energy="-10.3" /TU="NA" /idTUdmin="U2665" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 3052339..3052950 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="precursor of killing factor SdpC" /protein_id="NP_391257.1" /db_xref="EnsemblGenomes-Gn:BSU33770" /db_xref="EnsemblGenomes-Tr:CAB15382" /db_xref="GOA:O34344" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG14076" /db_xref="UniProtKB/Swiss-Prot:O34344" /translation="MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYF RGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSID SKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNA VALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ*" /label="spbC CDS" gene 3052339..3052950 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /label="spbC gene" S_feature complement(3052632..3052718) /Source="Nicolas_S_feature" /locus_tag="new_3466069_3466155_c" /HighExp="T1.30H, Gly, T2.0H, BT, S8, C30, Lbstat, C90, T1.0H, M9-stat" /AntisenseName="spbC" /AntisenseCor="-5.4790207146846799E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1295" downshifts complement(3052675) /Source="Nicolas_upshifts" /id="D1752" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="4.62458" /MaxDrop="2.00358" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature complement(3052720..3052905) /Source="Nicolas_S_feature" /locus_tag="new_3466157_3466342_c" /HighExp="T1.30H, T2.0H, M9-stat, T1.0H, B60, T2.30H, T5.0H, B36, T3.30H, T0.30H" /AntisenseName="spbC" /AntisenseCor="-4.2394313806342503E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1296" downshifts complement(3052763) /Source="Nicolas_upshifts" /id="D1753" /incds=1 /nref=1 /ntot=14 /MaxReadThrough="4.27088" /MaxDrop="2.27366" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3052930 /Source="Nicolas_upshifts" /id="D1754" /incds=0 /nref=207 /ntot=252 /MaxReadThrough="4.65014" /MaxDrop="7.52715" /score="19.8036228" /energy="-20" /TU="U2660,U2663" /idTUdmin="U2660" /TUdmin="-1099" /isTUend="FALSE" /label="downshifts" downshifts complement(3052950) /Source="Nicolas_upshifts" /id="D1755" /incds=0 /nref=14 /ntot=94 /MaxReadThrough="6.14809" /MaxDrop="5.58575" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2667" /TUdmin=33 /isTUend="FALSE" /label="downshifts" S_feature 3052975..3054113 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" CDS complement(3052997..3053620) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 15849754, 16850406, 20563570, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 15849754, 16850406, 20563570, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="integral membrane immunity regulator of autophagy" /protein_id="NP_391258.1" /db_xref="EnsemblGenomes-Gn:BSU33780" /db_xref="EnsemblGenomes-Tr:CAB15383" /db_xref="GOA:O32241" /db_xref="InterPro:IPR012867" /db_xref="InterPro:IPR025962" /db_xref="InterPro:IPR026272" /db_xref="SubtiList:BG14077" /db_xref="UniProtKB/Swiss-Prot:O32241" /translation="MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSK PLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGY EVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLV VCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR*" /label="sdpI CDS" gene complement(3052997..3053620) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /label="sdpI gene" downshifts complement(3053005) /Source="Nicolas_upshifts" /id="D1756" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="6.43517" /MaxDrop="3.3455" /score="8.72167152" /energy="-11.6" /TU="U2665,U2667" /idTUdmin="U2667" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3053617..3053889) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 17069462, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of SdpC synthesis operon (ArsR family)" /protein_id="NP_391259.1" /db_xref="EnsemblGenomes-Gn:BSU33790" /db_xref="EnsemblGenomes-Tr:CAB15384" /db_xref="GOA:O32242" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14078" /db_xref="UniProtKB/Swiss-Prot:O32242" /translation="MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHH LNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL*" /label="sdpR CDS" gene complement(3053617..3053889) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /label="sdpR gene" promotor_-10 complement(3053945..3053964) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3053954) /Source="Nicolas_upshifts" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3053956..3054104) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" promotor_-35 complement(3053976..3053982) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3054109..3054798) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(3054109..3054798) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(3054149) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 3054741..3054749 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3054763..3054782 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3054777 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3054816..3055727) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(3054816..3055727) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(3055747..3056400) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(3055747..3056400) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(3056423..3057565) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(3056423..3057565) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(3057609..3057628) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(3057624) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(3057643..3057646) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 3057762..3057769 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3057782..3057801 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3057793 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 3057829..3058386 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 3057829..3058386 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 3058387..3059151 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(3058404..3059039) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(3058404..3059039) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(3058417) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3059080..3059098) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3059086) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3059114..3059120) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3059125..3059132 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3059144..3059163 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3059153 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 3059189..3059803 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 3059189..3059803 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 3059789 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 3059857..3059860 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3059875..3059894 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3059883 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 3059935..3060633 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 3059935..3060633 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 3060606 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(3060669..3062486) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(3060669..3062486) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(3060688) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(3060859) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(3062528..3062547) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 3062532..3062551 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3062537 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3062541) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3062606..3063073 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 3062606..3063073 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 3063070 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(3063118..3064410) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(3063118..3064410) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(3063128) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3064440..3065975) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(3064440..3065975) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(3065968..3066729) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(3065968..3066729) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(3066760..3067944) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(3066760..3067944) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(3067945..3068185) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(3068185) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3068187..3068260) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(3068199..3068218) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3068234..3068238) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3068261..3069268) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(3068261..3069268) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 3069187..3069190 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3069207..3069209 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3069209 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3069315..3070337) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(3069315..3070337) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(3069331) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3069359..3069360) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3070338..3070449) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 3070375 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3070430..3070449) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3070449) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3070451..3070561) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(3070463..3070470) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3070544..3070563) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(3070559) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(3070576..3070585) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(3070635..3072029) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(3070635..3072029) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(3070649) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3072128..3072147) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3072142) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3072162..3072169) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3072169..3072176 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3072190..3072209 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3072196 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 3072233..3073321 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 3072233..3073321 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 3073301 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3073370..3074380) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(3073370..3074380) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(3073377) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3074381..3074458) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3074448..3074467) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074458) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3074481..3074488) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3074537..3075415) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(3074537..3075415) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 3075073..3075079 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3075094..3075105 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3075105 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3075449..3075456 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3075462..3075481) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3075467) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 3075470..3075489 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3075472 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3075495..3075499) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3075515..3076432 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 3075515..3076432 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 3076421 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3076473..3077816) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(3076473..3077816) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(3077885..3078120) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(3077885..3078120) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(3078019) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3078121..3078217) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3078218..3079252) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(3078218..3079252) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(3079274..3079292) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079280) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3079305..3079312) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3079360..3080082) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(3079360..3080082) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(3079376) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(3080082..3081521) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(3080082..3081521) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 3081069..3081072 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3081089 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3081090..3081094 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3081243 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3081397 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3081398..3081399 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3081548..3082264) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(3081548..3082264) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 3082168..3082175 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3082189..3082191 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3082189 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3082262 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(3082265..3082331) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3082328..3082347) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3082331) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(3082362..3082369) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3082439..3083041) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(3082439..3083041) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(3083058..3084173) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(3083058..3084173) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(3084177..3084914) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(3084177..3084914) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(3084203..3084222) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3084217) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(3084234..3084241) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3084915..3085820) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(3084915..3085820) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(3085840..3085858) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3085851) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3085874..3085877) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3086029..3086036 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3086047..3086066 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3086054 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 3086104..3086913 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 3086104..3086913 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 3086949..3088160 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 3086949..3088160 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 3088147 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3088214..3089503) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(3088214..3089503) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(3089583..3091646) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(3089583..3091646) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(3091665..3092516) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(3091665..3092516) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(3092520..3093776) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(3092520..3093776) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(3093816..3095081) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(3093816..3095081) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(3095113..3095132) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3095135) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3095147..3095154) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3095222..3096214) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(3095222..3096214) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(3095256) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(3096344..3096393) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3096367) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3096394..3097053) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(3096394..3097053) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(3097054..3097159) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3097151..3097170) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3097160) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3097185..3097188) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3097212..3097219 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3097234..3097253 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3097234 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 3097237..3097342 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3097243..3097260) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3097247) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3097268..3097274) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3097343..3099034 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 3097343..3099034 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 3099019 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3099061..3100371) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(3099061..3100371) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 3099064..3100134 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3099073) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3100191..3100210 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3100191..3100449 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3100191 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3100385..3100404) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3100400) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3100419..3100422) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3100450..3100668 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 3100450..3100668 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 3100647 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3100678..3101646) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" /label="epsO CDS" gene complement(3100678..3101646) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /label="epsO gene" CDS complement(3101625..3102791) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" /label="epsN CDS" gene complement(3101625..3102791) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /label="epsN gene" CDS complement(3102796..3103446) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" /label="epsM CDS" gene complement(3102796..3103446) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /label="epsM gene" CDS complement(3103443..3104051) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" /label="epsL CDS" gene complement(3103443..3104051) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /label="epsL gene" CDS complement(3104048..3105565) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" /label="epsK CDS" gene complement(3104048..3105565) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /label="epsK gene" CDS complement(3105562..3106596) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" /label="epsJ CDS" gene complement(3105562..3106596) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /label="epsJ gene" CDS complement(3106593..3107669) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" /label="epsI CDS" gene complement(3106593..3107669) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /label="epsI gene" CDS complement(3107674..3108708) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" /label="epsH CDS" gene complement(3107674..3108708) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /label="epsH gene" CDS complement(3108733..3109836) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" /label="epsG CDS" gene complement(3108733..3109836) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /label="epsG gene" CDS complement(3109833..3110987) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" /label="epsF CDS" gene complement(3109833..3110987) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /label="epsF gene" CDS complement(3110980..3111816) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" /label="epsE CDS" gene complement(3110980..3111816) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /label="epsE gene" CDS complement(3111813..3112958) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" /label="epsD CDS" gene complement(3111813..3112958) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /label="epsD gene" CDS complement(3112970..3114766) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" /label="epsC CDS" gene complement(3112970..3114766) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /label="epsC gene" S_feature complement(3114767..3114826) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3114800..3114818) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3114826) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3114832..3114838) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3115025..3115708) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" /label="epsB CDS" gene complement(3115025..3115708) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /label="epsB gene" CDS complement(3115714..3116418) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" /label="epsA CDS" gene complement(3115714..3116418) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /label="epsA gene" upshifts 3116400 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3116403..3116421 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3116419..3116476) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3116472..3116491) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3116477) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3116505..3116512) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3116594..3116599 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3116614..3116633 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3116620 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="upshifts" CDS 3116664..3117122 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" /label="slrR CDS" gene 3116664..3117122 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /label="slrR gene" promotor_-35 3117144..3117147 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3117153 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3117164..3117182 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3117198..3118667 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 3117198..3118667 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 3118644 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 3118670..3118861 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 3118670..3118861 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 3118840 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(3118888..3119373) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(3118888..3119373) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(3119396..3119707) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(3119396..3119707) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(3119759..3119851) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(3119759..3119851) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(3119891..3119910) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3119908) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3119924..3119931) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3119982..3120665) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(3119982..3120665) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(3120000) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(3120681..3122036) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(3120681..3122036) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(3122048..3122063) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122064) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3122075..3122084) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3122338..3122345 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3122359..3122378 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3122362 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 3122384..3122574 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3122575..3123996 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 3122575..3123996 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 3123990 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3124070..3125620 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 3124070..3125620 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 3125664..3125670 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3125684..3125695 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3125684 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 3125728..3127290 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 3125728..3127290 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 3127268 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3127280..3127969 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 3127280..3127969 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 3127319..3127326 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3127340..3127359 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3127349 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 3127950 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(3128048) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 3128051..3128386 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 3128051..3128386 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 3128386..3128706 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 3128386..3128706 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 3128707..3128897 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3128742..3129254) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(3128742..3129254) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 3128874 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3129290..3129301) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3129296) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3129316..3129322) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3129369..3129505) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3129412) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(3129506..3130849) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(3129506..3130849) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(3130878..3130897) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130886) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3130910..3130919) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3130911..3130916 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3130932..3130950 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3130935 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3131144..3131153 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3131162 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3131167..3131186 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3131205..3132167 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 3131205..3132167 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 3132168..3132421 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3132448) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(3132452..3132527) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(3132452..3132527) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(3132554..3132573) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132575) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3132589..3132592) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3132658..3132664 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3132674..3132749 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3132674 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3132679..3132698 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3132726..3132733 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3132747..3132766 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3132751 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 3132797..3133390 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 3132797..3133390 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 3133379 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 3133424..3133822 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3133436..3134116) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(3133436..3134116) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(3133460) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(3134113..3135798) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(3134113..3135798) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(3135791..3138064) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(3135791..3138064) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(3138042..3138926) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(3138042..3138926) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(3138932..3139768) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(3138932..3139768) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(3139769..3141076) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(3139769..3141076) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 3140134..3140143 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140156..3140175 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140160 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3141116..3142369) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(3141116..3142369) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(3142370..3142464) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3142465..3144234) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(3142465..3144234) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 3144155..3144160 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3144176..3144194 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3144186 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3144272..3144291) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144285) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3144304..3144311) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3144347..3145297) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(3144347..3145297) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(3145312..3145330) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3145325) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3145342..3145350) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3145431) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3145503..3146078) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(3145503..3146078) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(3145515) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3146121..3146140) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3146127..3146134 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3146137) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 3146144 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3146147..3146166 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3146155..3146162) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3146195..3146515 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 3146195..3146515 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 3146496 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3146542) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3146542..3148134) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(3146542..3148134) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(3148153..3148746) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(3148153..3148746) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(3148788..3148807) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3148801) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3148822..3148826) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3148872..3148877 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3148893..3148911 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3148894 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3149067..3149074 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3149088..3149107 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3149092 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 3149129..3150106 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 3149129..3150106 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 3150078 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3150144..3152084) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(3150144..3152084) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(3150168) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(3152059..3152838) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(3152059..3152838) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(3152839..3152920) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3152921..3153991) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(3152921..3153991) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(3153985..3154698) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(3153985..3154698) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(3154744..3154763) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3154756) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3154758..3155019) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3154776..3154779) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3154779..3154786 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3154797..3154816 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3154802 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3154845..3155054 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 3154845..3155054 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 3155032 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3155064) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3155090..3155854) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(3155090..3155854) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(3155112) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3155855..3156112) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(3155855..3156112) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(3156136..3157086) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(3156136..3157086) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(3157109..3158062) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(3157109..3158062) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(3158064..3158951) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(3158064..3158951) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(3158976..3159452) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(3158976..3159452) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(3159472..3159491) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3159486) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3159507..3159511) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3159530..3159549) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3159543) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3159564..3159567) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3159619..3159769) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3159662) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(3159770..3160720) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(3159770..3160720) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(3160721..3160808) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3160797..3160816) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160808) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3160810..3160901) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3160831..3160834) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3160849..3160855 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3160869..3160887 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3160883 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 3160884..3164270 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3160926..3162347) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(3160926..3162347) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(3160946) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(3161070) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 3161974..3161978 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3161984 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3162263..3162267 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3162270 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3162348..3162545) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3162468 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3162533..3162552) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3162545) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(3162564..3162571) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3162728..3164182) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(3162728..3164182) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(3162748) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(3164183..3164307) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3164228 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3164308..3166077) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(3164308..3166077) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(3166078..3166152) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3166141..3166160) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3166152) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(3166242..3166601) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(3166242..3166601) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(3166262) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3166616..3168526) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(3166616..3168526) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(3168528..3169253) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(3168528..3169253) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(3169254..3169342) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3169342..3169361) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3169342) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3169344..3169473) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3169377..3169380) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3169499..3170128) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(3169499..3170128) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(3169518) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(3170125..3170883) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(3170125..3170883) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(3170880..3171617) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(3170880..3171617) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(3171614..3172252) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(3171614..3172252) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 3172110..3172210 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3172170 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3172253..3172837) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(3172253..3172837) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3172834..3174117) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3172834..3174117) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3174114..3174755) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3174114..3174755) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3174748..3175923) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3174748..3175923) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3175924..3176001) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3175967..3175973 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3175985..3176004 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3175985..3176004) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3175998 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3176001) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3176017..3176024) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3176133..3176152 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3176140 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3176174..3176926 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3176174..3176926 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3176927..3177165 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3176948..3176959) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3176954) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3176974..3176980) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3177166..3177831 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3177166..3177831 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3177802 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3177851..3178369) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3177851..3178369) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3177885) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3178373..3179023) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3178373..3179023) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3179020..3179958) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3179020..3179958) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3179982..3180791) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3179982..3180791) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3180805..3181737) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3180805..3181737) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3181779..3181798) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3181785) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3181814..3181819) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3181854..3181861 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3181873 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3181876..3181893 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3181919..3183109 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3181919..3183109 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3182907..3182913 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3182928 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3182929..3182947 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3183106..3183834 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3183106..3183834 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3183852..3184583 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3183852..3184583 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3184603..3188472) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3184603..3188472) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3184725) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3188492..3188503) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3188499) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3188518..3188524) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3188562..3188568 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3188582..3188601 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3188587 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3188637..3189110 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3188637..3189110 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3189111..3189218 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3189151..3190368) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3189151..3190368) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3189164) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3189190..3189195 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3189210..3189221 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3189220..3189505 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3189220 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3189462 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3190384..3191130) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3190384..3191130) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3191131..3191317) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3191303..3191322) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3191317) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3191336..3191343) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3191451..3191458 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3191473..3191492 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3191485 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3191486..3191555 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3191556..3192065 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3191556..3192065 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3191961..3193299) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3192002) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3192086..3193297 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3192086..3193297 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3193295 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3193325..3193684) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3193325..3193684) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3193340..3194056 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3193344) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3193686..3193883) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3193686..3193883) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3193888..3194985) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3193888..3194985) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3195010..3195336) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3195010..3195336) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3195389..3195404) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3195404) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3195406..3195896) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3195416..3195425) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3195484..3195487 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3195502..3195521 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3195512 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3195554..3195784 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3195554..3195784 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3195887..3195906) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3195897) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3195922..3195926) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3195983..3196465) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3195983..3196465) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3195991 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3196006) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3196138) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3196146..3196149) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3196226..3196230) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196226) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3196246..3196249) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3196466..3196599) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3196627..3199500) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3196627..3199500) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3196644) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3199508..3201493) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3199508..3201493) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3201527..3201546) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3201539) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3201541..3201626) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3201558..3201565) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3201671) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3201679..3201909) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3201679..3201909) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3201936..3201955) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3201946) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3201948..3202012) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3201969..3201976) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3201989..3202007) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3202010) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3202022..3202028) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3202078) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3202104..3202204) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3202144) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3202226..3202233 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3202247..3202266 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3202264 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3202356..3204851 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3202356..3204851 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3204866..3204870 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3204884 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3204927..3205496 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3204927..3205496 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3205527..3206861 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3205527..3206861 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3206842 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3206909..3208102) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3206909..3208102) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3206918) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3206983) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3208103..3208180) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3208106) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3208181..3208519) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3208181..3208519) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3208494..3208610) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3208494..3208610) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3208611..3208700) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3208682..3208700) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3208700) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3208702..3208782) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3208714..3208719) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3208768..3208786) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3208782) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3208800..3208807) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3208919..3210361) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3208919..3210361) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3209008) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3210407..3210418) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3210418) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3210433..3210439) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3210501..3211391) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3210501..3211391) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3210518) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3211384..3212070) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3211384..3212070) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3212071..3212203) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3212193..3212212) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3212203) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3212227..3212230) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3212304..3212642) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3212304..3212642) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3212305) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3212669..3212688) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3212682) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3212691..3213575) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3212691..3213575) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3212702..3212709) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3213563..3213582) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3213584) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3213597..3213604) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3214732..3214803), complement(3213702..3214730)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3213702..3214803) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3213718) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3214804..3214872) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3214873..3217398) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3214873..3217398) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3217399..3217479) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3217469..3217488) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3217479) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3217566..3218135) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3217566..3218135) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3217574) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3218102..3218108 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3218121..3218140 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3218128 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3218162..3218180) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3218170) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3218172..3218292) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3218192..3218200) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3218276..3218294) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3218292) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3218310..3218315) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3218326..3218703) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" /label="yvzG CDS" gene complement(3218326..3218703) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /label="yvzG gene" CDS complement(3218713..3219054) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" /label="fliT CDS" gene complement(3218713..3219054) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /label="fliT gene" CDS complement(3219051..3219452) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" /label="fliS CDS" gene complement(3219051..3219452) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /label="fliS gene" CDS complement(3219474..3220970) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" /label="fliD CDS" gene complement(3219474..3220970) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /label="fliD gene" CDS complement(3220988..3221317) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" /label="yvyC CDS" gene complement(3220988..3221317) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /label="yvyC gene" downshifts 3221314 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3221339..3221357) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3221354) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3221356..3221460) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3221371..3221378) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3221449..3221468) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3221460) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="upshifts" CDS complement(3221550..3222464) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" /label="hag CDS" gene complement(3221550..3222464) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /label="hag gene" downshifts complement(3221570) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature complement(3222465..3222573) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3222531..3222532 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3222541..3222555 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3222550 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3222552..3222570) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3222573) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="upshifts" promotor_-35 complement(3222583..3222590) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3222609..3222833) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" /label="csrA CDS" gene complement(3222609..3222833) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /label="csrA gene" downshifts complement(3222648) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3222827..3223258) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" /label="fliW CDS" gene complement(3222827..3223258) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /label="fliW gene" CDS complement(3223279..3223854) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" /label="yviE CDS" gene complement(3223279..3223854) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /label="yviE gene" CDS complement(3223901..3224797) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" /label="flgL CDS" gene complement(3223901..3224797) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /label="flgL gene" downshifts complement(3223924) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" misc_feature 3224213..3224216 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3224222 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3224808..3226331) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " /label="flgK CDS" gene complement(3224808..3226331) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /label="flgK gene" CDS complement(3226350..3226832) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3226350..3226832) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3226848..3227114) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3226848..3227114) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3227115..3227194) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3227195..3227614) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3227195..3227614) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3227653..3227671) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3227664) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3227685..3227692) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3227688..3228410) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3227688..3228410) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3228374..3228670) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3228374..3228670) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3228696..3228715) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3228709) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3228726..3228733) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3228730..3230121) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3228730..3230121) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3230135..3230154) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3230150) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3230168..3230175) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3230227..3231072) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3230227..3231072) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3230238) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3230489..3230496 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3230510..3230529 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3230520..3232252 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3230520 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3231099..3231118) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3231118) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3231133..3231136) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3231170..3231859) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3231170..3231859) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3231184) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3231860..3231941) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3231942..3233099) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3231942..3233099) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3233100..3233227) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3233147..3233150 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3233165..3233184 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3233176..3233262 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3233176 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3233221..3233240) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233227) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3233244..3233252 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3233251..3233258) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3233264 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3233266..3233274 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3233316..3233969 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3233316..3233969 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3233672..3234264) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3233969..3235144 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3233969..3235144 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3234260..3234278) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3234269) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3234292..3234298) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3235116 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3235217..3236293) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3235217..3236293) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3235233) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3235279..3235288 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3235302..3235321 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3235310..3236543 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3235310 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3236294..3236376) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3236364..3236383) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3236376) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3236395..3236401) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3236438..3237631) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3236438..3237631) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3236468) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3237660..3238418) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3237660..3238418) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3238442..3239122) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3238442..3239122) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3239151..3240617) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3239151..3240617) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3240618..3240701) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3240702..3242087) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3240702..3242087) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3242149..3243318) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3242149..3243318) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3243315..3244766) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3243315..3244766) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3244822..3244971) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3244822..3244971) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3244916..3245455) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3244916..3245455) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3245511..3245528) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3245515) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3245682..3247172) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3245682..3247172) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3245704) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3247211..3249328) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3247211..3249328) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3249352..3249660) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3249352..3249660) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3249566 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3249656..3249660 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3249669..3249683 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3249670..3249688) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3249676 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3249702..3249709) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3249705) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3249726..3249734 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3249748..3249761 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3249766 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3249844..3250764 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3249844..3250764 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3250754 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3250804..3251946) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3250804..3251946) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3250828) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3251985..3252004) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3251999) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3252019..3252022) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3252075..3252079 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3252095..3252114 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3252096..3252191 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3252097 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3252192..3253070 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3252192..3253070 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3253071..3254162 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3253140..3253495) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3253404..3253622 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3253404..3253622 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3253496..3253579) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3253496..3253579) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3253580..3253771) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3253772..3256474) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3253772..3256474) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3256475..3256597) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3256496..3256502 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3256517..3256535 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3256522..3259354 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3256522 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3256598..3257938) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3256598..3257938) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3257979..3258185) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3257979..3258185) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3258186..3259059) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3259053..3259072) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3259059) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3259061..3259300) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3259085..3259091) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3259282..3259300) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3259300) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3259314..3259321) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3259323..3259330 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3259342..3259361 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3259356..3259486 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3259356 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3259428..3259528 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3259488 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3259492..3260088 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3259492..3260088 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3259686 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3260127..3261710) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3260127..3261710) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3260170 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3261730..3262557) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3261730..3262557) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3262558..3262622) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3262618..3262637) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3262622) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3262624..3262721) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3262653..3262656) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3262722..3264962) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3262722..3264962) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3264962..3266983) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3264962..3266983) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3265725..3265734 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3265747..3265762 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3265758 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3266984..3267143) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3267144..3267533) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3267144..3267533) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3267534..3267668) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3267652..3267671) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3267668) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3267682..3267689) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3267823..3267829 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3267840..3267932 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3267840 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3267841..3267860 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3267933..3268703 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3267933..3268703 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3268060..3268408) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3268412..3268423) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3268416) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3268438..3268444) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3268728 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3268736..3269881 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3268736..3269881 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3269869 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3269923..3269930 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3269945..3269964 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3269955 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3270001..3271329 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3270001..3271329 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3271324 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3271385) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3271389..3274031) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" /label="lytD CDS" gene complement(3271389..3274031) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /label="lytD gene" promotor_-10 complement(3272634..3272653) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272636) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3272666..3272675) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3274066..3274084) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3274071) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3274098..3274105) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3274160..3275110) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" /label="pmiA CDS" gene complement(3274160..3275110) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /label="pmiA gene" downshifts complement(3274172) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3275135..3275153) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3275140) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3275142..3275278) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3275168..3275174) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3275252..3275271) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3275280) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3275308..3275314 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3275328..3275339 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3275328 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="upshifts" CDS 3275375..3276826 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" /label="gerBA CDS" gene 3275375..3276826 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /label="gerBA gene" CDS 3276832..3277938 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" /label="gerBB CDS" gene 3276832..3277938 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /label="gerBB gene" CDS 3277935..3279059 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" /label="gerBC CDS" gene 3277935..3279059 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /label="gerBC gene" S_feature complement(3278162..3279056) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3279049 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3279096..3280469) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" /label="ywtG CDS" gene complement(3279096..3280469) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /label="ywtG gene" downshifts complement(3279101) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" /label="downshifts" S_feature complement(3280470..3280533) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3280521..3280539) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3280534) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3280554..3280560) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3280620..3280629 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3280641..3280656 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3280643..3280763 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3280643 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3280738..3280745 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3280759..3280778 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3280765 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3280802..3281770 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" /label="tagT CDS" gene 3280802..3281770 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /label="tagT gene" downshifts 3281755 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" /label="downshifts" promotor_-35 3281814..3281821 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3281836..3281855 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3281843..3281925 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3281843 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3281926..3282786 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" /label="ribZB CDS" gene 3281926..3282786 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /label="ribZB gene" downshifts 3282767 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3282820..3284061) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3282820..3284061) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3282839) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3284083..3284101) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284105) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3284114..3284121) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3284202..3284369) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3284202..3284369) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3284229) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3284384..3285526) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3284384..3285526) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3285545..3285994) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3285545..3285994) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3285688..3285694 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3285702 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3285708..3285726 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3285715..3287924 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3286009..3287190) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3286009..3287190) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3287904..3287911 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3287926 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3287927..3287946 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3287947) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3287952..3287966) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3287974..3287978) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3287974..3288954 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3287974..3288954 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3288803..3288810 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3288824..3288843 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3288839 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3288956..3289837 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3288956..3289837 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3289834..3290229 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3289834..3290229 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3290245..3291726 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3290245..3291726 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3291728..3292696 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3291728..3292696 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3292708..3293625 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3292708..3293625 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3293634..3293640 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3293655..3293673 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3293657 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3293707..3294243 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3293707..3294243 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3294226 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3294271..3294381 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3294350..3294356 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3294371..3294382 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3294383 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3294399..3294695 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3294399..3294695 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3294696..3295348 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3294735..3295262) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3294735..3295262) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3294745) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3295282..3295301) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3295295) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3295306 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3295315..3295322) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3295361) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3295362..3296129) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3295362..3296129) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3296191..3297903) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3296191..3297903) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3296802..3296811 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3296825..3296844 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3296825 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3297957..3297976) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3297962) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3297982..3297989 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3297991..3297995) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3298003..3298022 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3298013 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3298061..3298969 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3298061..3298969 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3299037..3299045 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3299047..3299179 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3299047 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3299059..3299078 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3299180..3300508 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3299180..3300508 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3300499 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3300565..3301242) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3300565..3301242) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3300575) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3301302..3302444) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3301302..3302444) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3302481..3302500) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3302489) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3302491..3302571) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3302514..3302522) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3302572..3303660) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3302572..3303660) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3303661..3303774) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3303716..3303725 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3303738..3303757 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3303751 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3303774) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3303778..3303792) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3303801..3303805) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3303801..3304388 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3303801..3304388 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3303889..3304368 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3303889..3304368 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3304272..3304469) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3304305 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3304315) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3304374 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3304453 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3304468..3304487) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3304474) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3304496..3304503 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3304500..3304509) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3304518..3304537 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3304524 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3304562..3305179 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3304562..3305179 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3305180..3305280 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3305237 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3305306..3305315 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3305327..3305342 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3305328 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3305357..3305692 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3305357..3305692 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3305648..3305666) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3305657) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3305681..3305686) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3305691 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3305697..3307274) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3305697..3307274) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3305736..3307447 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3307425..3307432 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3307443..3307462 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3307449 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3307488..3307964 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3307488..3307964 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3307978..3308571 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3307978..3308571 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3308568..3309104 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3308568..3309104 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3309085 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3309131..3309352) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3309131..3309352) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3309299 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3309306..3309307 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3309349..3309894) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3309349..3309894) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3309911..3309918 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3309933..3309952 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3309937 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3310017..3310898 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3310017..3310898 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3310983..3311699) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3310983..3311699) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3311003) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3311709..3312173) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3311709..3312173) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3312163..3313971) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3312163..3313971) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3313990..3314250) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3313990..3314250) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3314260..3314682) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3314260..3314682) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3314683..3314765) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3314757..3314776) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3314765) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3314789..3314796) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3314899..3315024) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3314899..3315024) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3314942..3315073) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3314985) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3315074..3315859) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3315074..3315859) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3315860..3315975) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3315968..3315987) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3315975) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3316001..3316008) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3316051..3317373) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3316051..3317373) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3316063) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3317407) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3317409..3317534) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3317409..3317427) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3317443..3317448) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3317514..3317533) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3317534) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3317568..3318332) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3317568..3318332) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3318351) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3318385..3319098) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3318385..3319098) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3318402) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3319088..3319834) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3319088..3319834) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3319866..3319885) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3319878) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3319902..3319905) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3320068..3320211) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3320068..3320211) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3320089) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3320212..3320297) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3320287..3320298) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3320297) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3320299..3320529) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3320336..3320340 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3320356..3320375 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3320365 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3320415..3322025 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3320415..3322025 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3320517..3320535) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3320529) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3320531..3320705) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3320549..3320556) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3320692..3320711) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3320705) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3320725..3320733) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3322012..3324780 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3322012..3324780 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3324829) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3324906..3325763) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3324906..3325763) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3325769..3326545) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3325769..3326545) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3326571..3326590) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3326593) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3326595..3326667) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3326605..3326612) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3326669..3326768) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3326712) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3326769..3327110) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3326769..3327110) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3327132..3327151) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3327151) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3327165..3327172) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3327187..3327570) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3327187..3327570) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3327592..3327611) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3327599..3327618 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3327603 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3327612) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3327626..3327633) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3327693..3327712 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3327696 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3327745) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3327745..3328155 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3327745..3328155 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3328156..3328239 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3328197 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3328295..3328603) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3328295..3328603) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3328296) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3328947..3329783 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3328947..3329783 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3329163..3329170 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3329185..3329204 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3329188 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3329782 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3329830..3330222) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3329830..3330222) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3329836) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3330295..3330720) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3330295..3330720) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3330781..3330800) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3330797) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3330799..3330883) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3330815..3330822) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3330862 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3330865..3330884 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3330875..3330894) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3330883) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3330885..3331969) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3330908..3330913) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3330912..3331976 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3330912..3331976 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3331977..3332861 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3331999..3332808) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3331999..3332808) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3332014) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3332842..3333654) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3332842..3333654) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3333655..3333734) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3333685..3333692 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3333706..3333725 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3333715 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3333728..3333746) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3333734) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3333760..3333767) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3333817..3334818) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3333817..3334818) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3333823) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3334873..3334892) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3334897) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3334899..3334983) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3334984..3335265) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3334984..3335265) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3335280..3335390) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3335280..3335390) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3335421..3335439) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3335443) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3335455..3335460) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3335536..3335542 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3335556..3335575 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3335572 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3335615..3336028 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3335615..3336028 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3336050..3337240 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3336050..3337240 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3337331..3338737) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3337331..3338737) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3337628) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3338770..3338789) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3338788) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3338804..3338807) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3338843..3340315) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3338843..3340315) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3340496..3341854) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3340496..3341854) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3340510) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3341854..3342423) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3341854..3342423) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3342442..3342453) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342460) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3342467..3342473) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3342530..3342697) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3342530..3342697) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3342607..3343071) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3342607..3343071) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3343101..3343120) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343106) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3343134..3343141) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3343272..3343275 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3343290..3343309 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3343294 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3343353..3344567 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3343353..3344567 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3344183..3344201) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3344184) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3344215..3344222) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3344433..3344439 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3344453..3344472 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3344455 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3344579..3344929 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3344579..3344929 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3344922 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3344981..3344989 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3345003..3345011 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3345010 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3345052..3345061 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3345074..3345089 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3345078 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3345110..3345691 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3345110..3345691 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3345208..3345227) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345218) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3345241..3345249) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3345672 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3345732..3346154) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3345732..3346154) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3345751) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3346189..3346204) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3346208) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3346217..3346226) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3346265..3347116) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3346265..3347116) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3346274) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3346516) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3346753..3346755 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3346772..3346791 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3346773..3347119 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3346773 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3347111..3347114 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3347121..3347256 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3347121 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3347150) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3347156..3347165) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3347257..3347748 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3347257..3347748 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3347486..3347491 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3347507..3347525 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3347518 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3347609..3348517) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3347745..3348263 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3347745..3348263 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3348068 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3348266 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3348422..3348553 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3348422..3348553 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3348550..3348984) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3348550..3348984) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3348562) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3349033..3349052) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3349040) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3349042..3349339) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3349067..3349074) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3349113..3349117 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3349134..3349153 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3349146..3349226 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3349147 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3349227..3350675 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3349227..3350675 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3349339) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3349340..3349358) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3349341..3349684) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3349374..3349380) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3349662..3349680) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3349684) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3349696..3349701) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3350664 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3350696..3351469) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3350696..3351469) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3350718) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3351544..3351547 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3351563..3351582 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3351567 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3351614..3351997 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3351614..3351997 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3351984 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3352032..3352673) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3352032..3352673) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3352082) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3352741..3353142) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3352741..3353142) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3353191..3353210) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3353201) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3353203..3353276) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3353225..3353230) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3353277..3354986) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3353277..3354986) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3354983..3355357) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3354983..3355357) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3355354..3355671) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3355354..3355671) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3355672..3355756) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3355756) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3355758..3355771) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3355758..3355851) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3355852..3356016) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3355852..3356016) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3355939..3355957) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3355951) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3355969..3355977) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3356017..3356188) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3356189..3356371) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3356189..3356371) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3356372..3356518) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3356506..3356525) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3356518) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3356520..3356634) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3356540..3356547) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3356621,3356623) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3356648 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3356651..3356655 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3356668..3356856) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3356668..3356856) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3356679) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3356846 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3356882..3356900) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3356893) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3356914..3356920) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3356929..3357429) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3356929..3357429) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3357465..3357484) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3357472) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3357498..3357504) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3357564..3358697) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3357564..3358697) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3357582) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3358724..3358743) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3358731) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3358794..3358812) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3358810) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3358826..3358833) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3358889..3359914) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3358889..3359914) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3358902) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3359930..3360718) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3359930..3360718) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3360744..3360763) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3360750) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3360752..3360963) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3360777..3360784) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3360964..3361125) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3360964..3361125) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3361138..3361156) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3361158) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3361170..3361176) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3361219..3361893) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3361219..3361893) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3361234) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3361946..3362086) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3361946..3362086) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3362217..3362900) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3362217..3362900) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3363277..3363281 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3363286..3364317) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3363286..3364317) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3363296..3363315 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3363302) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3363314 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3364345..3364363) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364358) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3364360..3364477) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3364379..3364384) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3364419..3364424 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3364436..3367096 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3364436 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3364440..3364458 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3364513..3365823) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3364513..3365823) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3364522) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3365847..3365866) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3365854) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3365857..3366597) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3365857..3366597) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3365880..3365889) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3366228) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3366230..3366238) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3366252..3366260) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3366352..3366367) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3366360) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3366380..3366389) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3366598..3366725) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3366726..3366956) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3366726..3366956) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3366957..3367219) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3367092..3367111 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3367098 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3367126..3367599 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3367126..3367599 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3367203..3367222) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3367219) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3367221..3367604) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3367237..3367240) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3367633..3368031) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3367633..3368031) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3367649) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3368023..3368041) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3368032) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3368055..3368061) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3368055..3369476) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3368055..3369476) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3369502..3370365) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3369502..3370365) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3370366..3370441) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3370442..3371950) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3370442..3371950) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3371967..3372512) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3371967..3372512) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3372509..3373021) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3372509..3373021) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3373022..3373183) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3373184..3373396) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3373184..3373396) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3373442..3374176) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3373442..3374176) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3373990..3374090 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3374050 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3374184..3374567) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3374184..3374567) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3374256..3374274) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3374258) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3374568..3374838) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3374800..3374809 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3374809 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3374814..3374833) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3374823..3374842 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3374838) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3374840..3374961) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3374846..3374853) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3374990..3375619) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3374990..3375619) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3375006) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3375663..3375682) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3375686) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3375697..3375704) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3375754..3377001) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3375754..3377001) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3375777) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3377043..3377062) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3377060) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3377062..3377146) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3377077..3377082) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3377191) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3377208..3377750) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3377208..3377750) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3377763..3378212) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3377763..3378212) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3378213..3378312) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3378304..3378323) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3378312) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3378337..3378344) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3378369..3378821) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3378369..3378821) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3378838..3378857) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3378856) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3378872..3378875) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3378897..3379454) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3378897..3379454) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3379481..3379499) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3379494) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3379515..3379520) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3379533..3380573) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3379533..3380573) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3379538) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3380574..3380638) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3380628..3380647) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380638) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3380640..3380729) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3380663..3380667) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3380730..3381173) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3380730..3381173) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3381240..3381914) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3381240..3381914) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3381676..3381694) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3381683) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3381709..3381715) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3381946..3381963) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3381947) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3381979..3381984) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3382020 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3382024..3382043 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3382055..3382417 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3382055..3382417 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3382430) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3382434..3382721) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3382434..3382721) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3382722..3382780) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3382778..3382797) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3382781..3383647) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3382781..3383647) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3382794) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3382810..3382819) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3383649..3384719) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3383649..3384719) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3383652) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3384720 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3384747..3384766) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3384771) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3384773..3384884) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3384780..3384786) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3384816..3384835 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3384830 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3384845..3385231 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3384845..3385231 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3384866..3384884) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3384884) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3384898..3384905) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3385299..3385307 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3385318..3385336 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3385319 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3385353..3385907 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3385353..3385907 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3385837..3385841 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3385842 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3385886 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3385941..3386900) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3385941..3386900) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3385963) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3386938..3386956) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3386952) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3386971..3386977) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3386982..3388730) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3386982..3388730) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3387456..3387474) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3387464) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3387489..3387495) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3388731..3388821) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3388805..3388824) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3388821) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3388838..3388845) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3388964) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3388969..3389556) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3388969..3389556) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3389645..3389845) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3389645..3389845) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3389658) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3389846..3389923) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3389919..3389938) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3389923) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3389952..3389959) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3389964..3391247) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3389964..3391247) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3391248..3391550) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3391278..3391439) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3391278..3391439) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3391530..3391549) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3391550) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3391565..3391569) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3391654..3392619) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3391654..3392619) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3391660) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3392236..3392245 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3392258..3392277 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3392266 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3392650..3393939) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3392650..3393939) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3393940..3394299) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3394318..3394956) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3394318..3394956) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3394344) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3394957..3395075) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3395076..3395933) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3395076..3395933) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3395934..3396060) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3396042..3396061) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3396060) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3396075..3396082) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3396114..3396488) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3396114..3396488) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3396528..3396546) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3396542) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3396544..3397183) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3396545..3396548 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3396557..3396565) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3396564..3396583 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3396577 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3396591..3396596 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3396612..3396631 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3396622 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3396654..3397175 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3396654..3397175 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3397118..3397121 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3397136..3397155 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3397150 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3397173..3397192) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3397183) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3397194 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3397207..3397214) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3397257..3398864) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3397257..3398864) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3397270) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3398865..3399052) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3399040..3399059) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399052) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3399074..3399081) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3399106..3399627) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3399106..3399627) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3399162) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3399628..3399730) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3399711..3399730) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399730) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3399732..3399809) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3399746..3399749) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3399810..3400949) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3399810..3400949) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3400946..3403063) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3400946..3403063) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3403064..3403122) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3403123..3403142) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3403136) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3403156..3403163) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3403162..3403168 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3403182..3403193 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3403187 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3403218..3404414 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3403218..3404414 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3403410..3404288) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3404278..3404296) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3404289) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3404312..3404317) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3404427..3405389 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3404427..3405389 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3405403..3405409 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3405424..3405442 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3405424 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3405470..3405742 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3405470..3405742 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3405476) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3405732 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3405777..3406183 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3405784..3406308) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3405784..3406308) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3405806) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3406318..3408045) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3406318..3408045) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3408079..3408098) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3408093) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3408112..3408118) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3408134..3409636) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3408134..3409636) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3409660..3409678) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3409678) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3409693..3409699) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3409723..3410095) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3409766) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3410122..3410793) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3410122..3410793) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3410140) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3410790..3411344) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3410790..3411344) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3411370..3412833) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3411370..3412833) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3412823..3416509) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3412823..3416509) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3416540..3416559) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3416564) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3416566..3416695) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3416705..3417181) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3416705..3417181) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3416740) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3417204..3417223) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3417216) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3417238..3417241) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3417288 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3417291..3417310 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3417325..3418044 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3417325..3418044 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3418028 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3418076..3418792) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3418076..3418792) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3418078) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3418148) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3418818..3418837) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3418830) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3418891..3420078) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3418891..3420078) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3420108..3420127) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3420126) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3420214..3421884) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3420214..3421884) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3420216) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3421881..3422309) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3421881..3422309) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3422377..3422391 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3422377..3422396) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3422384 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3422393) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3422413..3422416) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3422448..3422467) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3422460) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3422489,3422496) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3422490..3422495 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3422496..3424974 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3422497..3423873) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3422497..3423873) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3423912..3425267) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3423912..3425267) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3425303..3425322) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3425321) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3425335..3425344) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3425447..3425466 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3425448 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3425493) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3425497..3426642 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3425497..3426642 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3426501..3426505 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3426522..3426541 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3426529 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3426612) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3426626..3426745 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3426626..3426745 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3426730 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3426775..3426843 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3426844..3427317 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3426844..3427317 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3427306 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3427349..3428221) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3427349..3428221) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3427360) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3427426) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3428282..3429112) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3428282..3429112) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3429113..3429208) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3429196..3429215) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3429207) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3429228..3429235) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3429253..3429258 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3429274..3429292 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3429276 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3429314..3431389 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3429314..3431389 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3431442) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3431566..3431681) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3431609) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3431682..3432200) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3431682..3432200) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3432214..3432873) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3432214..3432873) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3432896..3432899 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3432909..3432928) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3432914..3432933 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3432917 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3432927) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3432929..3433212) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3432943..3432950) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3432982..3433170 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3432982..3433170 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3433159 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3433213..3433632) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3433213..3433632) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3433682..3433701) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3433693) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3433716..3433723) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3433752..3435668) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3433752..3435668) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3434946..3434964) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434951) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3434981..3434985) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3435699) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3435722..3435943) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3435722..3435943) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3435975..3436196) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3435975..3436196) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3436228..3436490) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3436239 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3436271) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3436278..3436433) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3436278..3436433) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3436440..3436443 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3436452..3436465 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3436459 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3436467..3436486) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3436490) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3436500..3436506) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3436513..3437913) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3436513..3437913) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3437913..3438383) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3437913..3438383) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3438339) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3438495..3438995) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3438495..3438995) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3438498) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3439031..3440332) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3439031..3440332) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3440356..3440375) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3440370) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3440372..3440493) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3440391..3440393) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3440494..3440718) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3440494..3440718) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3440719..3440803) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3440792..3440811) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3440802) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3440826..3440829) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3440869..3440875 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3440890..3440901 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3440891 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3440933..3441709 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3440933..3441709 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3441695 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3441797..3441804 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3441819..3441838 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3441823..3446049 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3441823 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3441853..3442743) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3441853..3442743) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3442743..3442843) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3442783) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3442911..3443756) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3442911..3443756) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3443074) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3443805..3444704) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3443805..3444704) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3444747..3444766) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3444750) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3444780..3444787) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3444851) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3444851..3445822) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3444851..3445822) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3445857..3445876) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3445882) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3445892..3445896) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3445970..3445981) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3445973) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3445995..3446001) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3446044..3446063 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3446051 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3446092..3446856 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3446092..3446856 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3446843 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3446919..3446925 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3446939..3446958 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3446948 /Source="Nicolas_upshifts" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3446989..3447768 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /EC_number="1.3.1.-" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 20052993, 23519407, 25644640" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 20052993, 23519407, 25644640; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis" /protein_id="NP_391648.1" /db_xref="EnsemblGenomes-Gn:BSU37680" /db_xref="EnsemblGenomes-Tr:CAB15795" /db_xref="GOA:P39644" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3U49" /db_xref="PDB:3U4C" /db_xref="PDB:3U4D" /db_xref="SubtiList:BG10632" /db_xref="UniProtKB/Swiss-Prot:P39644" /translation="MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVK EDILAKHPEASVIVLAGDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCN IEDMTATFTQKTVAYIDAIKRASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAA LINASKNISIQLAPHNITVNCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGI PMKRVGSAEETAALAAFLASEEASYITGQQISADGGSMKSI*" /label="bacG CDS" gene 3446989..3447768 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /label="bacG gene" downshifts 3447745 /Source="Nicolas_upshifts" /id="D1955" /incds=0 /nref=84 /ntot=226 /MaxReadThrough="3.12719" /MaxDrop="4.87473" /score="3.07615905" /energy="-11.9" /TU="U2965" /idTUdmin="U2964" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3447783..3448982) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /function="16.4: Excrete" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanine aminotransferase forming tetrahydrotyrosine in bacilysin synthesis" /protein_id="NP_391649.1" /db_xref="EnsemblGenomes-Gn:BSU37690" /db_xref="EnsemblGenomes-Tr:CAB15796" /db_xref="GOA:P39643" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10631" /db_xref="UniProtKB/Swiss-Prot:P39643" /translation="MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDL PTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGG GKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKI DPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKP ASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGL QQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTF ETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG SLQETSR*" /label="bacF CDS" gene complement(3447783..3448982) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /label="bacF gene" CDS complement(3448983..3450167) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux protein for bacilysin excretion, self-protection against bacilysin" /protein_id="NP_391650.1" /db_xref="EnsemblGenomes-Gn:BSU37700" /db_xref="EnsemblGenomes-Tr:CAB15797" /db_xref="GOA:P39642" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR022324" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10630" /db_xref="UniProtKB/Swiss-Prot:P39642" /translation="MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSG VIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALL FITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVEL AVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTM ITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLT YFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFS VAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKG VF*" /label="bacE CDS" gene complement(3448983..3450167) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /label="bacE gene" CDS complement(3450164..3451582) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /EC_number="6.3.2.49" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine-anticapsin ligase" /protein_id="NP_391651.1" /db_xref="EnsemblGenomes-Gn:BSU37710" /db_xref="EnsemblGenomes-Tr:CAB15798" /db_xref="GOA:P39641" /db_xref="InterPro:IPR011761" /db_xref="PDB:3VMM" /db_xref="PDB:3WNZ" /db_xref="PDB:3WO0" /db_xref="PDB:3WO1" /db_xref="SubtiList:BG10629" /db_xref="UniProtKB/Swiss-Prot:P39641" /translation="MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASH AALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGAD AITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTT LEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVT FEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSH ITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNM IPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPE TAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQD VAESIRQIQQHAKLTAKYVLPV*" /label="bacD CDS" gene complement(3450164..3451582) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /label="bacD gene" CDS complement(3451601..3452362) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /EC_number="1.1.1.385" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroanticapsin 7-dehydrogenase" /protein_id="NP_391652.2" /db_xref="EnsemblGenomes-Gn:BSU37720" /db_xref="EnsemblGenomes-Tr:CAB15799" /db_xref="GOA:P39640" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="PDB:5ITV" /db_xref="PDB:5ITW" /db_xref="SubtiList:BG10628" /db_xref="UniProtKB/Swiss-Prot:P39640" /translation="MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEA MVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELS DWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVL QLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRL GKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ*" /label="bacC CDS" gene complement(3451601..3452362) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /label="bacC gene" CDS complement(3452365..3453072) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /EC_number="5.3.3.19" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-((4R)-4-hydroxycyclohexa-1, 5-dien-1-yl)-2-oxopropanoate isomerase" /protein_id="NP_391653.1" /db_xref="EnsemblGenomes-Gn:BSU37730" /db_xref="EnsemblGenomes-Tr:CAB15800" /db_xref="GOA:P39639" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:3H7J" /db_xref="PDB:3H7Y" /db_xref="PDB:3H9A" /db_xref="SubtiList:BG10627" /db_xref="UniProtKB/Swiss-Prot:P39639" /translation="MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPH TNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVI AIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMP FHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIF FPPRYNRAKAKKMKADE*" /label="bacB CDS" gene complement(3452365..3453072) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /label="bacB gene" misc_feature complement(3452968..3452969) /Source="Nicolas_upshift_promotors" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3452969) /Source="Nicolas_upshifts" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3453062..3453676) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /EC_number="4.1.1.100" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate decarboxylase" /protein_id="NP_391654.1" /db_xref="EnsemblGenomes-Gn:BSU37740" /db_xref="EnsemblGenomes-Tr:CAB15801" /db_xref="GOA:P39638" /db_xref="SubtiList:BG10626" /db_xref="UniProtKB/Swiss-Prot:P39638" /translation="MIILDNSIQTKKRTDSLSKLITVNTLGPEGTSSEYAAKHFISNF TLLQGLNSKLSLHDTFESCIERTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCD TPMYGLAVRPDFEFRDDMLDTSVIVSHPSPINLIKYFTRKDVRFKLVNSTSQAARKVK EGLYDIALTNELARQKYGLTFVKTFKSIPMSWSLFGKGDVDDEN*" /label="bacA CDS" gene complement(3453062..3453676) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /label="bacA gene" promotor_-35 3453234..3453240 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3453256..3453274 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3453267..3453878 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" upshifts 3453267 /Source="Nicolas_upshifts" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3453699..3453718) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3453715) /Source="Nicolas_upshifts" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3453733..3453740) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3453827) /Source="Nicolas_upshifts" /id="D1956" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="2.28302" /MaxDrop="5.44594" /score="19.4538123" /energy="-5.1" /TU="NA" /idTUdmin="U2969" /TUdmin=902 /isTUend="FALSE" /label="downshifts" CDS complement(3453828..3455066) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3453828..3455066) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3455108..3455127) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3455120) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3455139..3455146) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3455276..3456688) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3455276..3456688) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3455283) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3456688..3458388) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3456688..3458388) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3457357..3457373) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3457369) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3458462..3460009) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3458462..3460009) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3458469) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3460053) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3460055..3460235) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3460056..3460074) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3460236..3461510) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3460236..3461510) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3461511..3461593) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3461593) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3461606..3461624) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3461686) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3461687..3462151) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3461687..3462151) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3462152..3462262) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3462244..3462263) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3462262) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3462278..3462285) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3462473) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3462475..3462930) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3462475..3462930) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3462565..3462584 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3462573 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3462923..3463774) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3462923..3463774) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3463788..3464735) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3463788..3464735) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3464735..3465475) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3464735..3465475) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3465493..3465498 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3465499 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3465500..3466519) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3465500..3466519) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3465513..3465531 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3466383..3466392 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3466405..3466420 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3466416 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3466522..3467244) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3466522..3467244) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3467237..3468358) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3467237..3468358) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3468358..3469227) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3468358..3469227) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3469228..3470397) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3469228..3470397) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3470418..3471842) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3470418..3471842) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3471847..3472617) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3471847..3472617) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3472652..3472671) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3472666) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3472685..3472694) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3472785..3472790 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3472806..3472824 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3472808..3472936 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3472808 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3472937..3473482 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3472937..3473482 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3473468 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3473526..3473897) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3473526..3473897) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3473544) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3473959..3475281) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3473959..3475281) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3475301..3475618) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3475301..3475618) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3475647..3475666) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3475658) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3475680..3475686) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3475721..3475728 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3475744..3475763 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3475747 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3475786..3477156 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3475786..3477156 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3477181..3477858) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3477181..3477858) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3477195) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3477685..3477704) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3477701) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3477720..3477725) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3477872..3478678) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3477872..3478678) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3478171..3478189) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3478185) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3478204..3478210) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3478707..3478726) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3478713) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3478742..3478749) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3478768..3479301) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3478768..3479301) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3479349..3479984) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3479349..3479984) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3479977..3480315) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3479977..3480315) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3480337..3480356) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3480348) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3480371..3480378) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3480399..3480402 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3480417..3480436 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3480417 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3480459..3481274 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3480459..3481274 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3481253 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3481329) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3481364..3481612) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3481364..3481612) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3481384) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3481630) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3481632..3481705) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3481640..3481646) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3481706..3483145) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3481706..3483145) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3483142..3484527) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3483142..3484527) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3484546..3484555) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3484560) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3484562..3484626) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3484605..3484622) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484626) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3484638..3484645) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3484668..3484687) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484686) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3484701..3484708) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3484767..3484770 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3484777 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3484785..3484804 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3484829..3485599 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3484829..3485599 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3485600..3486667 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3485638..3486468) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3485638..3486468) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3485639) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3486494..3486513) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3486500) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3486508..3486810) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3486508..3486810) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3486528..3486535) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3486811..3486949) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3486934..3486953) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3486949) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3487264..3487272 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3487283..3487301 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3487284 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3487340..3489760 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3487340..3489760 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3487498 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3487507..3487526 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3489748 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3489798..3490799) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3489798..3490799) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3490800..3490961) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3490973..3491722) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3490973..3491722) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3491006) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3491740..3491759) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3491757) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3491774..3491777) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3491828..3493009) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3491828..3493009) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3491842) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3493010..3493141) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3493135..3493150) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3493141) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3493162..3493171) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3493376..3493383 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3493394..3493504 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3493394..3493413 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3493394 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3493505..3493768 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3493505..3493768 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3493658 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3493774 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3493811..3494185) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3493811..3494185) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3493822) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3494187..3494801) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3494187..3494801) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3494815..3496764) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3494815..3496764) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3496028..3496047 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3496034 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3496458..3496558 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3496518 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3496628 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3496792..3497757) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3496792..3497757) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3497758..3497826) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3497813..3497832) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3497826) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3497828..3498013) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3497845..3497849) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3497944..3497949 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3497965..3497983 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3497970 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3498004..3498023) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3498013) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3498015..3498124) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3498038..3498042) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3498080 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3498109..3498128) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3498124) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3498144..3498148) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3498202..3498220) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3498207..3498213 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3498219) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3498228..3498246 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3498231 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3498236..3498241) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3498273..3498518 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3498273..3498518 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3498500 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3498589..3500130) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3498589..3500130) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3498618) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3500134..3501306) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3500134..3501306) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3501324..3501342) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3501346) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3501357..3501363) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3501387..3501770) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3501387..3501770) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3501788..3502459) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3501788..3502459) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3502481..3502500) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3502490) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3502516..3502519) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3502600..3502603 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3502618..3502637 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3502627..3502814 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3502627 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3502815..3502973 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3502815..3502973 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3502974..3503358 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3503339..3503344 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3503360..3503378 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3503360 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3503416..3503724 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3503416..3503724 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3503502) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3503506..3503606) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3503546) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3503721..3505262 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3503721..3505262 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3505253 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3505293..3505895) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3505293..3505895) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3505307) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3505896..3506177) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3506178..3507428) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3506178..3507428) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3506274) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3507447..3508604) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3507447..3508604) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3507520..3507539) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3507547) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3508601..3510046) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3508601..3510046) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3510080..3510099) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3510090) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3510113..3510120) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3510203..3510871) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3510203..3510871) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3510212) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3510868..3511686) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3510868..3511686) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3511694..3512599) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3511694..3512599) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3512334..3512353) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3512345) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3512640..3512659) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3512650..3512657 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3512661) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3512669 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3512671..3512690 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3512675..3512682) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3512705..3513091 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3512705..3513091 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3513073..3513750 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3513073..3513750 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3513722 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3513794..3513801 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3513812 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3513815..3513834 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3513854..3515053 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3513854..3515053 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3515087..3515284 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3515087..3515284 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3515263 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3515319..3516509) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3515319..3516509) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3515334) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3515418) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3516533..3516552) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3516549) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3516569..3516576 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3516585 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3516590..3516609 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3516630..3517010 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3516630..3517010 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3516908 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3516979 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3517048..3517725) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3517048..3517725) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3517055) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3517734..3517753) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3517759) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3517765..3517771) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3517802..3519136) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3517802..3519136) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3519184..3519202) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3519207) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3519301..3519308 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3519313 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3519322..3519340 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3519364..3521301 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3519364..3521301 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3520508..3520527) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3520509) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3520541..3520549) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3521291 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3521404..3521411 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3521426..3521445 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3521445 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3521657..3521664 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3521677..3521696 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3521677 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3521729..3523108 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3521729..3523108 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3522817..3524020) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3523162..3524004 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3523162..3524004 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3524055..3524915) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3524055..3524915) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3524065) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3524899 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3524937..3524955) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3524955) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3524970..3524976) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3525025..3525738) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3525025..3525738) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3525140..3525141 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3525161..3525178 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3525163 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3525766..3525777) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3525767) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3525792..3525798) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3525813..3525819 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3525834..3525853 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3525844 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3525889..3526404 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3525889..3526404 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3526405..3526611 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3526405..3526611 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3526571 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3526653..3527894 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3526653..3527894 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3527985..3527993 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3528004..3528022 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3528015 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3528050..3529417 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3528050..3529417 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3529394 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3529447..3530079) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3529447..3530079) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3529465) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3530115..3530130) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3530123) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3530143..3530151) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3530221..3531156) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3530221..3531156) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3530233) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3530900..3530909 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3530923..3530942 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3530927 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3531157..3531244) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3531227..3531246) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3531244) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3531262..3531266) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3531289..3531301) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3531289) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3531316..3531322) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3531319..3531453) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3531319..3531453) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3531400..3531407 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3531421..3531440 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3531430 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3531433..3531537 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3531532..3531541 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3531539 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3531553..3531568 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3531575) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3531577..3531591) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3531603..3531752 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3531603..3531752 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3531770..3533281 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3531770..3533281 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3533278..3534465 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3533278..3534465 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3534482..3534718 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3534482..3534718 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3534718..3535896 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3534718..3535896 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3535897..3535986 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3535987..3536745 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3535987..3536745 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3536713 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3536747..3537974) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3536793..3536800 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3536814..3536833 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3536827 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3536886..3537977 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3536886..3537977 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3537879 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3537967 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3538011..3539339) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3538011..3539339) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3538019) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3539336..3539668) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3539336..3539668) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3539687..3541045) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3539687..3541045) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3541061..3541369) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3541061..3541369) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3541414..3541433) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3541430) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3541447..3541453) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3541498) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3541498..3543423) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3541498..3543423) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3542161..3542170 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3542184..3542203 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3542192 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3543496..3543513) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3543520) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3543528..3543535) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3543586..3543744) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3543586..3543744) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3543613) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3543773..3544363) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3543773..3544363) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3544391..3544409) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3544402) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3544423..3544429) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3544432..3544438 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3544454..3544472 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3544457 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3544492..3546135 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3544492..3546135 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3544629..3546178) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3546130 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3546180..3546271) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3546182..3546188 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3546196 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3546203..3546222 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3546223) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3546240..3547442 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3546240..3547442 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3546273..3547438) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3546316) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3547439..3548215) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3547439..3548215) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3548212..3549099) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3548212..3549099) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3549106..3549294) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3549106..3549294) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3549291..3549497) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3549291..3549497) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3549494..3549814) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3549494..3549814) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3549627..3549636 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3549649..3549668 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3549651 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3549807..3550343) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3549807..3550343) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3550371) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3550372..3550387) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3550399..3550408) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3550474..3550481 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3550495..3550514 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3550504 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3550555..3551928 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3550555..3551928 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3550835..3551377) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3551365..3551384) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3551377) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3551399..3551406) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3551763 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3551943..3552773) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3551943..3552773) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3551949) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3552792..3552810) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3552807) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3552825..3552831) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3552851) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3552853..3552872) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3552859..3554586) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3552859..3554586) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3552958) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3554583..3556286) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3554583..3556286) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3556286..3557302) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3556286..3557302) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3557176..3557194) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3557185) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3557210..3557215) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3557286..3558692) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3557286..3558692) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3558693..3558901) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3558884..3558903) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3558901) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3558903..3559011) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3558917..3558922) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3559008..3559027) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3559023) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3559041..3559048) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3559169..3559176 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3559186 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3559191..3559209 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3559248..3560600 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3559248..3560600 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3560199..3562681) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3560585 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3560676..3560695 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3560682 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3560722..3562410 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3560722..3562410 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3562408..3562417 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3562429..3562444 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3562433 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3562468..3562668 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3562468..3562668 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3562669..3563613 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3562682..3563521) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3562682..3563521) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3563547..3563565) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3563565) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3563578..3563585) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3563580 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3563628..3564725) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3563628..3564725) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3563629) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3564758..3564777) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3564775) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3564777..3564845) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3564790..3564797) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3564846..3565739) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3564846..3565739) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3565766..3565785) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3565785) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3565799..3565806) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3565813..3565818 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3565834..3565852 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3565843 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3565860..3565866 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3565881..3565899 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3565887 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3565923..3567380 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3565923..3567380 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3566806..3566824) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3566821) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3566839..3566844) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3567361 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3567405 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3567422..3568258) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3567422..3568258) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3567440) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3568335..3568437) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3568335..3568437) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3568361) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3568463..3568482) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3568474) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3568476..3569217) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3568496..3568502) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3568554..3568561 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3568574..3568592 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3568583 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3568593..3568678 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3568654..3568661 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3568675..3568694 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3568680 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3568826..3569368 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3568826..3569368 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3569193..3569212) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569217) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3569226..3569235) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3569358 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3569403..3569725 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3569443..3570462) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3569443..3570462) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3569461) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3570488..3570507) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3570502) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3570522..3570525) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3570577..3571083) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3570577..3571083) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3571089..3571108) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3571111) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3571113..3571116 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3571122..3571128) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3571131..3571150 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3571134 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3571213..3572088 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3571213..3572088 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3571463..3571551) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3571485) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3571511..3571611) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3571551) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3572166..3572639 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3572166..3572639 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3572657..3573877 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3572657..3573877 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3573864..3574520 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3573864..3574520 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3574518..3574523 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3574537..3574556 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3574540 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3574570..3575802 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3574570..3575802 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3574587) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3575787 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3575848..3575857 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3575870..3575885 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3575872..3576094 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3575872 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3576051 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3576105..3576111 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3576124..3576224 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3576124 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3576126..3576144 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3576203..3576210 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3576224..3576242 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3576226..3576323 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3576226 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3576324..3576587 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3576324..3576587 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3576351..3576354 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3576369..3576388 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3576381 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3576535 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3576579 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3576654..3576663 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3576669 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3576675..3576690 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3576716..3577204 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3576716..3577204 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3577209..3577216 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3577230..3577249 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3577240 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3577270..3577376 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3577270..3577376 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3577371 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3577459..3578592 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3577459..3578592 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3577732..3577975) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3577970..3577989) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3577979) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3578004..3578011) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3578598..3578605 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3578620..3578639 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3578626 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3578661..3578767 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3578661..3578767 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3578714 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3578768..3578844 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3578845..3579981 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3578845..3579981 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3579968 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3580034..3580807) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3580034..3580807) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3580044) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3580824..3581474) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3580824..3581474) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3581471..3582187) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3581471..3582187) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3582211..3583629) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3582211..3583629) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3582797..3582815) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3582816) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3582831..3582836) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3583630..3583714) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3583698..3583716) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3583714) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3583732..3583737) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3583783..3584631) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3583783..3584631) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3583793) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3584632..3584817) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3584806..3584825) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3584817) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3584819..3585544) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3584841..3584845) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3584979..3584986 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3584999..3585018 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3585008 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3585018..3585120 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3585018..3585120 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3585121..3585224 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3585196..3585202 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3585216..3585227 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3585226 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3585247..3586440 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3585247..3586440 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3585531..3585549) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3585547) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3585562..3585569) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3586216 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3586436 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3586482..3586910) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3586482..3586910) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3586911..3587153) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3586911..3587153) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3587154..3587217) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3587206..3587221) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3587217) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3587233..3587242) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3587250 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3587298..3587588) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3587298..3587588) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3587304) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3587613..3587632) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3587630) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3587638..3589698) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3587638..3589698) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3587646..3587653) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3589727..3589745) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3589731) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3589760..3589766) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3589791..3589796 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3589810 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3589812..3589830 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3589824..3589898 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3589899..3591179 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3589899..3591179 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3591180..3591319 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3591276 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3591337..3592065) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3591337..3592065) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3591354) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3592096..3592115) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3592107) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3592129..3592136) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3592253..3592360) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3592296) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3592361..3593194) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3592361..3593194) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3593225..3593244) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3593244) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3593258..3593265) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3593290..3593970) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3593290..3593970) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3594017..3594036) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3594026) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3594050..3594057) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3594118..3594121 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3594136..3594155 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3594136 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3594177..3595463 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3594177..3595463 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3594908..3594926) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3594916) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3594940..3594947) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3595434 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3595482..3596921) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3595482..3596921) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3595505) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3596945..3596964) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3596962) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3597003..3598151) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3597003..3598151) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3598178..3598194) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3598194) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3598196..3598280) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3598209..3598214) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3598281..3598469) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3598281..3598469) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3598500..3598631) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3598500..3598631) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3598643..3599104) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3598643..3599104) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3599120..3599416) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3599120..3599416) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3599444..3599932) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3599444..3599932) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3599950..3600402) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3599950..3600402) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3600403..3600471) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3600472..3600801) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3600472..3600801) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3600802..3600923) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3600924..3601340) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3600924..3601340) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3601391..3601759) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3601391..3601759) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3601753..3602223) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3601753..3602223) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3602224..3602548) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3602549..3602977) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3602549..3602977) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3603039..3610043) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3603039..3610043) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3610050..3610064 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3610064 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3610074..3610093) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3610089) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3610108..3610115) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3610205..3611140) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3610205..3611140) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3610426) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3611141..3611261) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3611292..3611738) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3611292..3611738) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3611306) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3611775..3611794) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3611782) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3611808..3611815) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3611841..3613250) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3611841..3613250) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3613273..3615102) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3613273..3615102) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3615094..3615194) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3615134) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3615136..3615328) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3615309..3615328) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3615328) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3615330..3615463) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3615341..3615348) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3615485..3615793) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3615485..3615793) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3615508) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3615839..3616282) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3615839..3616282) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3616279..3617988) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3616279..3617988) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3617150..3617169) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3617158) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3618008..3618277) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3618008..3618277) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3618289..3618654) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3618289..3618654) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3618655..3618720) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3618707..3618726) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3618720) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3618741..3618744) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3618961..3620370) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3618961..3620370) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3618984) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3620371..3620480) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3620504..3620668) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3620504..3620668) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3620553..3620571) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3620568) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3620582..3620590) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3620860..3620879) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3620876) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3620892..3620899) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3620908..3620915 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3620930..3620949 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3620933 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3620987..3621433 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3620987..3621433 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3621438 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3621546..3623072 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3621546..3623072 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3623069..3624727 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3623069..3624727 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3624740..3626005 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3624740..3626005 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3625998..3626957 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3625998..3626957 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3626958..3627032 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3627033..3628460 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3627033..3628460 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3628456 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3628504..3629805) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3628504..3629805) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3628521) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3629835..3631016) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3629835..3631016) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3631017..3631096) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3631097..3631768) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3631097..3631768) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3631717..3631720 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3631735 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3631736..3631755 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3631796..3631815) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3631811) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3631829..3631836) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3631874..3632815) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3631874..3632815) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3632860..3632879) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3632866) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3632868..3632948) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3632895..3632898) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3632949..3633776) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3632949..3633776) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3633748) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3633801..3633819) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3633814) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3633833..3633839) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3633849..3634961) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3633849..3634961) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3635031..3636368) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3635031..3636368) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3636365..3637507) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3636365..3637507) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3637524..3638273) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3637524..3638273) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3638286..3638960) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3638286..3638960) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3638983..3639777) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3638983..3639777) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3639349..3639358 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3639370 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3639371..3639386 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3639802..3640299) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3639802..3640299) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3640313..3641638) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3640313..3641638) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3641715..3641734) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3641719) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3641748..3641755) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3641824..3642051) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3641824..3642051) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3642038..3643024) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3642038..3643024) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3642042) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3642175..3642184 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3642198..3642217 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3642208..3642841 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3642208 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3643079..3643098) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3643090) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3643113..3643120) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3643179..3643991) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3643179..3643991) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3644021..3644040) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3644031..3644588) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3644031..3644588) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3644044) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3644055..3644062) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3644569..3645003) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3644569..3645003) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3645028..3645037 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3645047 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3645050..3645069 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3645063) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3645064..3645475) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3645069..3645083) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3645092..3645096) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3645092..3645457 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3645092..3645457 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3645471 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3645475..3645479) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3645475) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3645477..3645563) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3645556..3645575) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3645563) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3645589..3645596) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3645636..3645642 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3645656..3645667 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3645663 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3645705..3646058 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3645705..3646058 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3646053 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3646102..3646500) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3646102..3646500) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3646110) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3646515..3646534) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3646531) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3646549..3646552) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3646588..3646595 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3646604..3646622) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3646610..3646629 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3646619 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3646619) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3646638..3646643) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3646678..3647643 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3646678..3647643 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3647071 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3647078..3647096 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3647550 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3647621 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3647666..3648462 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3647684..3648031) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3647684..3648031) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3647697) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3648045..3649913) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3648045..3649913) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3649888..3650661) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3649888..3650661) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3650805..3651782) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3650805..3651782) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3651779..3652468) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3651779..3652468) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3652495..3652514) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3652513) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3652529..3652535) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3652576..3653448) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3652576..3653448) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3652580) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3653469..3654305) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3653469..3654305) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3654306..3654390) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3654391..3655260) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3654391..3655260) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3655280..3656314) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3655280..3656314) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3656337..3657653) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3656337..3657653) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3657668..3658561) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3657668..3658561) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3658578..3660491) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3658578..3660491) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3660524..3661501) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3660524..3661501) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3661525..3662340) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3661525..3662340) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3662341..3662414) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3662415..3663878) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3662415..3663878) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3663879..3664083) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3663882..3663889 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3663905..3663924 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3663912 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3663919..3664225 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3664065..3664084) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3664083) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3664085..3664237) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3664099..3664106) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3664185..3664192 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3664207..3664226 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3664227 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3664238..3664257) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3664254) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3664273..3664280) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3664294..3665049 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3664294..3665049 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3665028..3665034 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3665049..3665068 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3665063 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3665103..3666035 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3665103..3666035 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3666037 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3666114..3666121 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3666135..3666154 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3666141..3666296 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3666141 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3666297..3666947 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3666297..3666947 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3666951..3667259 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3666951..3667259 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3667261 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3667403..3667409 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3667425..3667443 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3667435 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3667497..3668882 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3667497..3668882 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3668868 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3668913..3669463 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3668924..3670804) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3668924..3670804) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3668930) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3670805..3670902) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3670893..3670912) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3670902) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3670927..3670934) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3670972..3671223) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3670972..3671223) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3670990) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3671245..3671264) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3671254) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3671287..3671293 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3671307..3671325 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3671308 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3671340..3672161 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3671340..3672161 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3672145 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3672190..3673332) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3672190..3673332) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3672200) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3673333..3673432) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3673420..3673439) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3673431) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3673453..3673460) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3673475..3674812 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3673475..3674812 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3674217..3674817) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3674851..3675330) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3674851..3675330) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3674862) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3675410..3676402) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3675410..3676402) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3675434) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3676392 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3676425..3676444) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3676443) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3676459..3676466) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3676465..3676472 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3676486..3676910 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3676486 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3676487..3676506 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3676492..3676904 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3676492..3676904 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3676512) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3676522..3676536) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3676544..3676548) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3676876 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3676911..3677645 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3676911..3677645 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3677645..3677914 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3677645..3677914 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3677918..3678400 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3677918..3678400 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3678421..3680664 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3678421..3680664 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3680661..3681860 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3680661..3681860 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3681616..3681634) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3681638) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3681649..3681655) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3681851 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3681924) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3681924..3683156) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3681924..3683156) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3683188..3683207) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3683200) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3683221..3683226) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3683257..3683682) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3683257..3683682) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3683710..3683729) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3683724) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3683742..3683748) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3683874..3683881 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3683891 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3683896..3683915 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3683939..3684394 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3683939..3684394 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3684332 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3684395..3685008 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3684424..3685632) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3684424..3685632) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3684451) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3685633..3685739) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3685740..3686753) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3685740..3686753) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3686754..3686827) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3686812..3686831) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3686827) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3686844..3686851) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3686847..3687422) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3686847..3687422) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3686871) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3687451..3687470) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3687465) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3687485..3687492) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3687493..3687499 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3687514..3687532 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3687521 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3687553..3688623 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3687553..3688623 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3688621 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3688680..3689111) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3688680..3689111) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3689141..3689148 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3689162..3689181 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3689171..3689337 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3689171 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3689223..3689242) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3689243) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3689257..3689264) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3689338..3689742 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3689338..3689742 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3689359..3690411) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3689712..3690404 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3689712..3690404 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3690444..3691475) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3690444..3691475) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3690456) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3691442..3691445 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3691458 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3691462..3691481 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3691512..3691530) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3691530) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3691545..3691551) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3691568..3692716) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3691568..3692716) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3692755..3692774) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3692766) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3692785..3692792) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3692838..3692845 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3692859..3692878 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3692866 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3692912..3693643 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3692912..3693643 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3693636..3695177 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3693636..3695177 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3695206..3696552 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3695206..3696552 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3696005..3696009 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3696025..3696044 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3696034 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3696575..3697981 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3696575..3697981 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3697970 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3698078..3698097 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3698080..3698371 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3698080 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3698344..3698351 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3698366..3698385 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3698373 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3698395..3698402 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3698417..3698436 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3698420) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3698423..3698437) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3698432 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3698445..3698449) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3698445..3699008 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3698445..3699008 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3699022..3700551 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3699022..3700551 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3700378) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3700544 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3700577..3700660) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3700620) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3700661..3702100) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3700661..3702100) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3702114..3702344) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3702114..3702344) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3702345..3702556) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3702553..3702572) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3702558) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3702587..3702594) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3702620..3702627 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3702638..3702657 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3702653 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3702688..3703398 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3702688..3703398 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3703426..3703584 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3703426..3703584 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3703661 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3703715..3704437) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3703715..3704437) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3703727) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3704338..3704341 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3704357..3704361 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3704372 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3704458..3705087) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3704458..3705087) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3705088..3705236) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3705237..3705995) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3705237..3705995) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3705685..3705704) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3705701) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3705717..3705724) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3705976..3706935) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3705976..3706935) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3706924 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3706971..3706974 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3706979 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3706993..3707142) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3706993..3707142) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3707000) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3707051..3707068 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3707056 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3707137 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3707163..3707182) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3707184) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3707197..3707204) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3707477..3707484 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3707499..3707518 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3707503 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3707614..3709539 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3707614..3709539 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3709540..3710904 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3709752..3710072) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3710073..3711833) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3710073..3711833) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3710116) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3710901..3710902 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3710906 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3711833..3712231) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3711833..3712231) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3712224..3713669) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3712224..3713669) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3712919..3712926 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3712938..3712957 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3712948..3713997 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3712948 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3713670..3713930) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3713931..3714410) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3713931..3714410) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3714411..3714490) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3714491..3714661) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3714491..3714661) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3714702..3714721) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3714718) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3714735..3714740) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3714784..3714791 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3714804..3714823 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3714821 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3714846..3715259 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3714846..3715259 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3715239 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3715293..3716519) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3715293..3716519) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3715308) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3716542..3716560) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3716547) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3716572..3716580) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3716582..3716752) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3716582..3716752) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3716771..3716789) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3716789) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3716803..3716809) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3716857..3717105) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3716857..3717105) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3717121..3718284) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3717121..3718284) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3717155..3717173) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3717163) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3717185..3717193) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3718295..3719032) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3718295..3719032) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3719074..3719092) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3719080) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3719106..3719114) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3719174..3719644) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3719174..3719644) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3719187) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3719645..3719715) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3719676..3719682 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3719696..3719715 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3719697..3719716) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3719697 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3719715) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3719717..3719992) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3719731..3719738) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3719755..3720852 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3719755..3720852 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3719983..3720001) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3719992) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3720016..3720021) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3720576..3720584 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3720596..3720614 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3720609 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3720853..3720969 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3720853..3720969 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3720958 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3721206..3722096) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3721206..3722096) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3721212) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3721274) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3722170..3723573) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3722170..3723573) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3723574..3723795) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3723796..3725001) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3723796..3725001) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3725058..3725076) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3725061) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3725171..3725176 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3725191..3725210 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3725206 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3725242..3726627 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3725242..3726627 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3726609..3726797) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3726609..3726797) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3726914..3727042) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3726914..3727042) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3726966 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3727062..3728264) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3727062..3728264) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3727086) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3728296..3728307) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3728296) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3728322..3728328) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3728346..3729140) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3728346..3729140) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3729162..3730004) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3729162..3730004) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3729991..3731358) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3729991..3731358) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3730585,3730587) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3731348..3733183) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3731348..3733183) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3733191..3733898) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3733191..3733898) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3733899..3733995) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3733983..3734002) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3733995) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3733997..3734189) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3734018..3734021) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3734189) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3734199..3734218) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3734281) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3734282..3734354) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3734282..3734354) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3734390..3734466) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3734390..3734466) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3734467..3734547) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3734548..3734619) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3734548..3734619) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3734629..3734704) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3734629..3734704) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3734676..3734692 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3734689 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3734705..3734801) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3734785..3734804) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3734801) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3734818..3734825) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3734835..3734936) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3734875) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3734929..3736221) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3734929..3736221) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3734940) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3736261..3736280) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3736281) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3736295..3736302) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3736427..3736846) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3736427..3736846) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3736844..3736855) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3736855) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3736870..3736876) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3736967..3738331) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3736967..3738331) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3736987) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3737031) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3738362..3738381) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3738376) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3738396..3738398) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3738443..3738449 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3738464..3738482 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3738466 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3738501..3738701 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3738501..3738701 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3738671 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3738716..3739037 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3738749..3738952) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3738749..3738952) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3738953..3739253) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3739018..3739021 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3739036..3739055 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3739039 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3739073..3739213 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3739073..3739213 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3739214..3739285 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3739261) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3739264..3739278) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3739286..3739290) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3739286..3740494 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3739286..3740494 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3740475 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3740599..3742656 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3740599..3742656 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3742521 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3742693..3743142) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3742693..3743142) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3742707) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3743139..3745118) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3743139..3745118) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3743620..3743639) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3743623) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3744036..3744043 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3744057..3744075 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3744061..3744727 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3744061 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3745155..3746084) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3745155..3746084) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3746085..3746221) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3746203..3746222) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3746221) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3746237..3746242) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3746311..3746460) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3746311..3746460) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3746337) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3746499..3746518) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3746516) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3746532..3746538) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3746539..3746548 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3746561..3746580 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3746567 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3746579) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3746581..3747094) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3746583..3746597) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3746606..3746610) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3746606..3747088 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3746606..3747088 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3747075 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3747118..3747495) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3747118..3747495) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3747120..3747649 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3747139) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3747550..3747569) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3747562) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3747583..3747590) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3747631..3747635 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3747649..3747668 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3747651 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3747676..3747690) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3747679) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3747700..3748629 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3747700..3748629 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3748615 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3748658) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" /label="downshifts" CDS complement(3748662..3749108) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" /label="yybP CDS" gene complement(3748662..3749108) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /label="yybP gene" S_feature complement(3749109..3749439) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3749298..3749415) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /label="mswM RNA" gene complement(3749298..3749415) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /label="mswM gene" promotor_-10 complement(3749430..3749449) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3749438) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3749463..3749470) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3749476..3749482 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3749495 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3749497..3749515 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3749511..3749517 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3749532..3749543 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3749539 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" CDS 3749541..3750848 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" /label="yybO CDS" gene 3749541..3750848 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /label="yybO gene" downshifts complement(3750649) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 3750837 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3750892..3751131) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" /label="yyzI CDS" gene complement(3750892..3751131) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo /label="yyzI gene" downshifts complement(3750913) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3750917..3751017) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3750957) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3751121..3751285) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" /label="yyzJ CDS" gene complement(3751121..3751285) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo /label="yyzJ gene" CDS complement(3751297..3751482) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" /label="hypothetical protein CDS" gene complement(3751297..3751482) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /label="gene" downshifts 3751563 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" /label="downshifts" CDS complement(3751755..3751901) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" /label="yyzK CDS" gene complement(3751755..3751901) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo /label="yyzK gene" CDS complement(3751883..3752032) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" /label="yyzL CDS" gene complement(3751883..3752032) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo /label="yyzL gene" misc_feature complement(3752348..3752364) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3752365) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3752384..3752391 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3752406..3752609 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3752406..3752425 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3752406 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3752427..3752441) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3752431) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="upshifts" CDS 3752610..3753047 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" /label="yybN CDS" gene 3752610..3753047 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /label="yybN gene" S_feature 3753048..3753124 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3753081 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" /label="downshifts" CDS 3753161..3753916 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" /label="yybM CDS" gene 3753161..3753916 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /label="yybM gene" S_feature complement(3753756..3756345) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3753906..3754616 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" /label="yybL CDS" gene 3753906..3754616 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /label="yybL gene" downshifts 3754115 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" /label="downshifts" CDS 3754613..3755368 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" /label="yybK CDS" gene 3754613..3755368 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /label="yybK gene" CDS 3755365..3756020 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKLKRLQF*IISLIHLKKEQFMDYLGVMVLERPCYF VHYPG**SLLKGV*LLKVNNYIKISLFLKV*D*L*KICSYFLSMMLLLTLKFCQKLKR SHQIMIY*ILLVELVWKILIV*RLVNSR*E*NND*ILHRLFLKNLIYCYLMNQQMRLM KKELHLFMTFFYKRKKGELPLLLLVITRKILYLYVTLH*K*IMDV*KLQKK*YIRKIV " /label="yybJ CDS" gene 3755365..3756020 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /label="yybJ gene" S_feature 3756021..3756335 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3756292 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 3756336 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(3756390) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" /label="downshifts" CDS complement(3756395..3757183) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" /label="ictI CDS" gene complement(3756395..3757183) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /label="ictI gene" promotor_-10 complement(3757207..3757225) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3757226) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3757241..3757246) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3757251..3757640) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" /label="yybH CDS" gene complement(3757251..3757640) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /label="yybH gene" promotor_-35 3757709..3757712 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3757727..3757746 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3757740 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="upshifts" CDS 3757786..3758625 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" /label="yybG CDS" gene 3757786..3758625 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /label="yybG gene" downshifts 3758602 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3758658..3759872) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" /label="yybF CDS" gene complement(3758658..3759872) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /label="yybF gene" downshifts complement(3758676) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(3759873..3759976) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3759969..3759988) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3759977..3759984 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3759979) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3759998..3760017 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3760002..3760009) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3760010 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="upshifts" CDS 3760059..3760937 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" /label="yybE CDS" gene 3760059..3760937 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /label="yybE gene" CDS 3760951..3761394 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" /label="yybD CDS" gene 3760951..3761394 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /label="yybD gene" CDS 3761477..3761956 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " /label="yybC CDS" gene 3761477..3761956 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /label="yybC gene" downshifts 3761946 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(3762131..3762793) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" /label="yybB CDS" gene complement(3762131..3762793) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /label="yybB gene" CDS complement(3762940..3763392) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" /label="yybA CDS" gene complement(3762940..3763392) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /label="yybA gene" promotor_-35 3763416..3763423 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3763438..3763457 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3763440 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="upshifts" S_feature 3763442..3763511 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3763445..3763464) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3763447) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3763477..3763484) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3763512..3763958 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" /label="yyaT CDS" gene 3763512..3763958 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /label="yyaT gene" CDS 3763955..3764560 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" /label="yyaS CDS" gene 3763955..3764560 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /label="yyaS gene" CDS complement(3764655..3765176) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" /label="yyaR CDS" gene complement(3764655..3765176) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /label="yyaR gene" S_feature complement(3765177..3766004) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3765225..3765232 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3765246 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3765247..3765266 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3765312..3765586 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3765312 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3765315..3765320 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3765333..3765352 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3765587..3765943 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" /label="yyaQ CDS" gene 3765587..3765943 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /label="yyaQ gene" S_feature 3765944..3766102 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3765986..3766005) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3766004) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3766020..3766027) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3766103..3766669 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" /label="yyaP CDS" gene 3766103..3766669 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /label="yyaP gene" CDS complement(3767176..3768552) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" /label="tetB CDS" gene complement(3767176..3768552) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /label="tetB gene" CDS complement(3768586..3768648) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" /label="tetL CDS" gene complement(3768586..3768648) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /label="tetL gene" promotor_-10 complement(3768669..3768688) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3768688) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3768701..3768708) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3768836..3768842 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3768858..3768877 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3768864 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="upshifts" CDS 3768901..3769140 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" /label="yyaO CDS" gene 3768901..3769140 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /label="yyaO gene" downshifts 3769149 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 3769233..3769240 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3769256..3769275 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3769272 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="upshifts" CDS 3769291..3769707 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" /label="yyaN CDS" gene 3769291..3769707 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /label="yyaN gene" CDS 3769704..3770621 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" /label="yyaM CDS" gene 3769704..3770621 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /label="yyaM gene" misc_feature 3770648..3770667 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3770658 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3770662..3770681) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3770668) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3770693..3772762 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" /label="yyaL CDS" gene 3770693..3772762 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /label="yyaL gene" promotor_-35 complement(3770695..3770702) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3772726 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3772759..3773658) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" /label="yyaK CDS" gene complement(3772759..3773658) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /label="yyaK gene" downshifts complement(3772802) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3773687..3773706) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3773703) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3773705..3774936) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3773721..3773728) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3773799..3773806 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3773820..3773839 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3773826 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3773884..3775239 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" /label="yyaJ CDS" gene 3773884..3775239 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /label="yyaJ gene" promotor_-10 complement(3774922..3774941) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3774946) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3774955..3774964) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3775273..3775827) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3775273..3775827) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3775845..3776225) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3775845..3776225) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3776281..3777216) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3776281..3777216) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3777206..3777215 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3777229..3777248 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3777236 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3777260..3777279) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3777274) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3777275..3778033) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3777275..3778033) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3777292..3777299) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3777566..3778069 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3778028 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3778098..3778337) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3778098..3778337) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3778104) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3778172) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3778381..3778899) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3778381..3778899) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3778940..3779227) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3778940..3779227) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3779228..3779294) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3779293..3779312) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3779294) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3779326..3779331) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3779338..3780438) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3779338..3780438) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3780486..3780505) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3780501) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3780520..3780527) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3780565..3782568) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3780565..3782568) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3782619..3782825) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3782619..3782825) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3782787..3782806) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3782812) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3782821..3782827) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3782851..3782870) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3782862) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3782887..3782891) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3782919..3783935) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3782919..3783935) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3783968..3783986) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3783980) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3784002..3784007) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3784111) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3784295..3784300 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3784313..3784394 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3784313 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3784316..3784334 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3784395..3785012 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3784395..3785012 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3784983..3784991 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3785002 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3785005..3785023 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3785024 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3785051..3785899) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3785051..3785899) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3785071) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3785892..3786653) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3785892..3786653) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3786687..3786706) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3786705) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3786797) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3786800..3786808) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3786822..3786830) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3786834..3786842 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3786850 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3786854..3786872 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3786901..3787341 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3786901..3787341 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3787290 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3787392..3788243) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3787392..3788243) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3787411) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3788244..3788364) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3788365..3789084) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3788365..3789084) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3789098..3790984) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3789098..3790984) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3791005..3792384) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3791005..3792384) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3792385..3792515) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3792507..3792526) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3792515) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3792542..3792546) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3792570..3792589) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3792580) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3792603..3792610) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3792670..3792676 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3792681..3794966 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3792681 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3792691..3792710 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3792695..3793321) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3792695..3793321) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3792712) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3793318..3794103) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3793318..3794103) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3794148..3794167) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3794160) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3794162..3794247) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3794179..3794185) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3794248..3794598) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3794248..3794598) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3794599..3794749) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3794750..3794884) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3794750..3794884) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3794908..3795008 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3794920..3794939) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3794930) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3794932..3795000) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3794955..3794962) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3794968..>3795101 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3794968 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3794986..3795005) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3795000) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3795021..3795025) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3795102..3795249 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3795125..3795398) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3795251..3795510 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggcctttgt gagtaacatg atagtaatca 399541 tagagaagga ggctcgcaat tggctgaatt catattaaat gcagcggatt tcggtgttcc 399601 tagagatggt aaaacggatt cgacagaacg gattaatcag tgcctcagta cagctgtttc 399661 gaaaggctat catactgtct ggtttccaaa gggaacatat ttaatagacg caacgcttgg 399721 cggagatctt aatcagaggt ttcgaaacgc ggggatcatt gttcccggca accttgagat 399781 tatgatggac cccgaatgta tcatgaaagt gataccgaat agttcgtggg gttattccgc 399841 attttatgta ggcaagcaag agaatataac tatttccgga ggacaaatta tcggcgaacg 399901 ggatgagcat acgtatgcct cggcggggat aaggtcaacc catgaatggg gctttggcat 399961 atgtattgaa ggatgctcga atgttgtcat tgatgatgtg aaaatttccg attttaccgg 400021 cgatgggatc atagtcagcc caaggggatt aaagaccaat caagattatc gaacgtcaga 400081 gcaaattatc atccgccgct gtgaggttcg gcggtcgagg agaaataaca tttccattac 400141 cggatgtgac atggtcacgg tggaggaatg cttgattgaa gatgccggaa cggggaatgg 400201 aacagcgccg aaattcggaa ttgacattga aggatatggc gaaggtgacg ttgattatga 400261 ggaaccgatt aatgtatcaa ttcgcaataa ccactttgtt ggaaacgttt caagttctgt 400321 gaccaatttt aacgggtatg gcattttaat agaaggaaat cactcagaca atacaatcag 400381 ctacggatat gggacgcaaa cagtgatcaa gggcaatatt ctgagacgcc ctgaagacgc 400441 ggcggctgcg ccaagagtcg ggataaccgg actcggtgta tcacaaggaa aagagaccag 400501 tgatgcagtg atcgctggca acctcattac cggattttca actggaattg atgtcagggg 400561 aaagagcgtt cttgtgacga acaacaaaat cagcaacttt gaaaacacag ggatattggt 400621 ttatcagtcc tccgacgtaa aggtagacgg aaaccaaatt caaaacggac tgtctgaaac 400681 aaggcgcagc atcggtcttc gcgcagtgct gtcagatgac atcgcatttc tgaataactg 400741 tctcattcaa gtcgttgacg gtgtgaacgt ttccggcgga aatatgatca ttaaagataa 400801 tctcctgaga aaattcagcc ggggcatttg gattgctcaa gggaacgcgg tgattgaagg 400861 gaatacactg aatcctgacg cgtttgaagc agtgccggaa tcatattctg tttccgtcac 400921 aaacaatgcc ggcgccatca tcaaaaacaa tacatttaaa gagttcaaaa attaccccat 400981 ttattgctcc acaagtgcaa aaacctcaat tatcggcaac cacttagagc gatccccgct 401041 tttggtcacc atctatatca gcgcaggtgt gcatgagatt tttgataata ccatttcagt 401101 caacagaaca gccgggaatc cgattgtgat ttatctcaat ggctctgcag gctctatcat 401161 ctctggaaac accatcaata acctctccgc gggcactgcg acagctattc aaacaaacac 401221 gtcaaccaat tccaaaatca tcggcaaccg catttttaaa gggaccatca acaaacacag 401281 cagtgataca atagacggca atatgattgt ctgaaaaaag cgcccccctt taggggttct 401341 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 401401 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaacggctt 401461 ttgttaaact gaacccttga agcatgtcca tcaacacaga aatagctaat aaacaaatta 401521 atatgaatcc ggtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 401581 tctttggcgg agaagttata ccgcatctaa ccctaatgca taatctcaat tttaaaagga 401641 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 401701 aacaataccg attcaaaaga caagcagaat acagacgaaa ggaatcagga acagcagcaa 401761 gaaaaagaaa ggccggttct catttctcca agtttagcaa agaatatagc ggaaacgaaa 401821 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 401881 catgtccacc tagctgttat ctatatttct gggctggtcg ataataacac gatccatgag 401941 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 402001 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 402061 ttttccgagt taatgcttgg caatgcgctc atttttgctg atggccatga tgaagctttg 402121 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 402181 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgatccgg 402241 cgatacatta aaaatccgaa tttatgggtt gaaaaaatga aaaaaggttc tgttacgaat 402301 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 402361 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 402421 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 402481 gttgtagcgg gtaatctgtt agaaggaaga ttcgcgatta ttgtggacgg aacaccgttt 402541 gtgcttattg ccccagcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 402601 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 402661 gtggcaccag ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 402721 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccggctgt tgtggaggcg 402781 ctgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 402841 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 402901 ggtatcgtct ctccggcaat ggtgattatc gtggcactca ccgcgattgc gagcttcgca 402961 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 403021 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 403081 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 403141 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 403201 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 403261 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 403321 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 403381 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 403441 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 403501 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 403561 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 403621 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 403681 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 403741 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 403801 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 403861 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 403921 taaaaaagga gtcagcatgg aaaacacgca ggcgactgac ccgaaagcca ttcttcaggc 403981 agatggtttg gcggtttttg ataaggcagg atatttaaag tattggctgg aagatgatga 404041 aagcgtgggg gcagtctggc ttatgaataa gatccagcat acgtttatta atgctgactg 404101 gggcaagacg aaggatgcgg tcagcttgca ggttacccat caagatacaa agctggtacc 404161 gaaaatgcgg aacggacgcc cgtacatcca tgtgaaagtg tcggttgaag gtattataga 404221 tgctgtcaaa taccctttcc aattgtctga tcccaaggtg ctggccgcta ttgaaaaagc 404281 gctcaacaaa gagcttgaaa aggaaatcag ccatactgtg aaaaagatta agaagaataa 404341 aatagatttt atcggttttg gtgacacgat atatagaaag tatccggagc agtgggagaa 404401 aatgaaggac acttgggaca aagaatattt gccggaactg cccatcgatg tgaaggccga 404461 gacgtatatc agaaggacgg gattgcgaaa caatccgatc aaacaccagt ttaaagatga 404521 ttaggtctga agaaagggga agtgacagat ggaaaaagcc agaataagca taaggcagtt 404581 gtttgtcatg attatcattt ttgaactggg cagctcctta ttgattacac cgggatcaat 404641 ggcgggcagg gatgcttgga tagcagtttt attaggctgt gcgatcggac tgtttctttt 404701 ctatttgtat caaggcattt atcaatgtta tccgaattct tctccgaaag aatatatgga 404761 tgatatgctg ggaaccaagc tgagctggct gttttcattt ctctatatct tgtactttgc 404821 ctatattgcc gcaagggtgc tgcgtgactt tggagaaatg ctgctgacgt ttgcttatca 404881 tgatacacct atcattattg taaatgcttt attaatggta gtaagcatat atgccgtaag 404941 aaaaggaatt gaagtactcg cacgcgcggc cgaacttctt ttcggggcca tgtatttact 405001 gggcgcgatc ggccttgtgc tgattattgt ctcagggact atagacccgc acaatttaaa 405061 gccggttttg gcaaacggca tttctcctgt ccttcactct gttttcacac agaccatgta 405121 cgttccattt ggtgaagttg ttttatttgt gatgattttc cctaacctga atgacagaaa 405181 agatgtgaaa aaaatgggga tgatcgccat ggctattagc ggattgattg tggcgctcac 405241 cgtggcgatt aatattagcg tgcttgatgt tgatcttaca ctcagatccc agtttccgct 405301 tttaagcacg atccagacaa tcaaggtcga agaattttta gaccggctcg atgtcttttt 405361 tatgctggcg ctgatcatcg gcggcttctt taaggtcagc ctctacttat atgccactgt 405421 ggttgggaca tctacgctct ttaaggaaaa gaacccctct caattggctt atccgatggg 405481 attgggcatc ttaatccttt ctataacgat cgcgactaac ttttcggagc acttgaatga 405541 aggcctgaac gtggtgccgc tgtatattca tttgcctttt caattattgt ttccgctctt 405601 tctgtttatt gtggccgttt ggaaaaagaa acgaagagag aagtcaaaag gggaggaagc 405661 aaaaaaatga taaaaagagc ggggggatgc ggccgccgct ctttttatgt tcacttctat 405721 ataaaagggg gatatagggt gcgcccctgt ctgcactggc agaggcgcgt tttgttatac 405781 gactgcgacg ttttccttca cagtaaaact tcctcttgaa agtctgatat tgatgtctga 405841 cacttttgca atttgttcat cgtgcgtcac cataatgacg catttatctt ccttgtgcgc 405901 cagatcctga aagagccgta cgatctcttt tgatgtgtcc tcatcaaggt ttccggtcgg 405961 ttcatcggct acgataagat ccgtgtcaca gcagaaagcc cttgtaattg atacccgctg 406021 ctgctgtccg ccgctcagtg tgagcacttt ttgccgggct tgtttttcgt tgatgccaac 406081 cttctgcagc atgtcaagcg catatgattc tttgttcttt tctttagaac ctgtgatttc 406141 catagcggtt gtgacgttct gcaaagccgt catatacggg agcaggttgt acgcctgaaa 406201 gacgattgat acatattgat ttctgaaatt ggttaagccg attttagaaa ccgcttttcc 406261 gtcgtaaagg atgtttcctt cttttggtgc gtcaagtccg cctgccagag acaggaaagt 406321 ggttttcccc gtccctgatg ttccgacgat tgtgtagaat tttccttttt gaaagctgat 406381 gttaatatcc tgaaacaatg gctggctttt gtttttatac cagtagccga cttgttgaaa 406441 ttgtaataag ctcataggtt ccgcctcttt ctattcctgt tttgtcaata tcgttttcgg 406501 atgaagccgc agtactgaaa ttgacggcag caatgttgca atgattgcga ttaggatgcc 406561 gatcccgcca agtataagca tgtcgttcat agaaaccgcg acgttcagtg aatcgataac 406621 gtccacgttg gatgaactgt ggccgaacat tttgccgccc atgccgccac cgccgccggg 406681 catttgtccg cttgcggttt gcgttgaatc ggttgatgaa ctgatttgct gggataaaag 406741 ctgatttcca agctgattcg cgacgagatt tcccgtcaca gatgcaaggc cgatagcgat 406801 aacggccaca atcagaatct cagtcaagaa ctgtccaatc aatttccatc gtttttcacc 406861 gatggccatt aacacgccca tttcgtattt gcgctccctg attgacatca tgacaatcag 406921 gccaagaatg acggcgcctg ccactgatac aagatacacc acgtttttag agaaagaagc 406981 cacattttca atcggtccga ccatttgctg gtaaagctga tcgtttgtat tcagtgtgta 407041 cgtatcaaag tcaattgatg ttttcttcgc tgcttttacg aaagtatcca tatttttcgc 407101 gtcgtccata tagtaaacag ctgagtcaat cgtattttta tagtcgtcgc ctttcaatgc 407161 cgctgttgct gtgtaaggcg tataaagctt gttataagga tttaagaaag agaaattttg 407221 ggcttggtca tcacctgaag atgttgtttt ataaataccg acgatcttca gttttactgt 407281 tgtatcctca tccgttgctg attcaattgt gatcgaatcg ccaacgctta aatcattttc 407341 ttccgctaat gtttcgttga tcactgttac ttttttgccg acatctgatt ttgtaatcgc 407401 gcgtccgtct gtgatttttg aatctccgtc agagaaatca tcgactaacg ctgtgctgat 407461 gacaccttca atagaaagat cagcttgaac catttgcggt ccgccttgtc ctccgccttg 407521 actgttttta gcgtttgagc ttgaactgct ggagctggaa tcacttgaac tagagctttc 407581 aatcgcatca aagtttcccg cgttggctga agctgatgtg gtgtaattgt agctcttcac 407641 atgatcaagc gctgcaagct tattcgcatc agacactttg atcggtgtgg attcgaagct 407701 gcgcttttca ccgctgtcct gctgtttttc catttgcttt tggcggtcaa cctgaagtgt 407761 cacgcttcca ccgagttcct gtctggccag ttcgcttgac ttttgtgctg ccgactggat 407821 ggcgaggcct gatagaacaa agacacatat gactgtaaac acaaataatt gcaataacgt 407881 ttttcccttt ttagccttca tattccaaaa ggcccgtttg ataaagttca tttatgttcc 407941 tccgtatagg tatttttatt gataagaccg cctctggggc gcgtcccctt gctgataaat 408001 taatagtagt ccaaaggtat gaaaaaaata tgaacaatct atttctagtt gatgaaataa 408061 aaactaacaa ttgtgaaacg caaaaccttc tgtttaaaat ggtgctatta tataaaaaag 408121 catcaaaaca accggaggat ataatgaaaa tattaatgat agaagataat gttagtgtat 408181 gtacgatgac ggagatgttc ttttttaaag aaggttttga agccgaattc gttcatgacg 408241 ggttagaagg gtaccagcgt tttacggaag aaaattggga tctaatcatt ttggatatca 408301 tgcttccatc tatggacggc gtgaccatct gcagaaaaat aagagagaca agcacggtgc 408361 cgattatcat gctgactgcc aaagacactg aatcagatca ggtcatcggt tttgagatgg 408421 gggcggacga ttatgtcaca aagccgttca gcccgctgac attggttgcc cgcatcaaag 408481 ccgtcatcag aagatataag gcgacaggca aagcggttat tgatgaagat atgattgaaa 408541 cggaatgctt taccattaat aagaagacga gagaagtatt attaaacgga gagcctgtag 408601 aaaatctcac gccgaaggaa ttcgatctgc tttattacct tgtccaaaat ccgcggcagg 408661 tgttctccag agaacagctg cttgagcagg tatggggcta tcaattttat ggagatgagc 408721 gaacggttga cgttcatatc aaacggctgc ggaaaaagct tgccagcgag gacaagcctt 408781 tcctgtatac tgtgtgggga gtagggtata aatttgatga agattaaata tttatatcag 408841 ctgctgctaa gccatatcag cattttgatt ttagcgtttg tcattatcat ttctctgttt 408901 tcccactttg tgaaggaatt tgcctatcag aacaaagtag aggaattgac gtcatatgcg 408961 gtgcagattg caaatgaatt ccaatccggc caggtggaca tgcgcaggct ctatccttat 409021 caggacattt taagcacaag aaagacgcaa tttatcatct ttaatgaaga gcagcagcct 409081 tattttcttc ctgaaggctt tcatcaccca ccaagggaac agctgaagaa atcagaatgg 409141 aataagctga aaaaagggca gactgtcacg atcagggcag atggccgttt tgatgatgaa 409201 gtgtcccttg tggcgcagcc tatatttgtt cagaacgaat ttaaaggcgc cgttctgctg 409261 atttctccga tcagcggtgt tgaacagatg gtcaatcagg tcaacctcta tatgttttac 409321 gctgtgatca gcacgcttgt gattacgatt cttgtgagct ggcttctgtc caaattccat 409381 gtcaagcgga ttcaaaagct gagagaagcg acagataaag tggcttccgg cgattatgac 409441 atccatttgg aaaacagcta cggggacgaa atcggcgtac tggcgtctga ctttaatatc 409501 atggcgaaaa aactaaagca gtcaagggat gaaatcgagc gccttgagaa gcggagaagg 409561 cagtttatcg ctgacgtgtc acatgaatta aaaacaccgc tgacgacgat caacggtttg 409621 gttgaagggt tgaacagcca tacgattcct gaggataaaa aggataaatg cttctcgctg 409681 atcagtgagg aaacgaagcg catgctgcgg ctcgtaaaag aaaatctgga ttatgaaaaa 409741 atcagatccc agcaaattac cttgaacaag ctagacgttc ctctgatcga ggtgtttgaa 409801 atcgtgaaag agcacttgca gcagcaggcg gaagaaaaac aaaacaagct gatgatccaa 409861 gtagaggatc acgtcatcgt acatgccgat tatgaccggt tcattcaaat tctcgtcaac 409921 attacgaaaa acagcatcca atttacgcaa aacggtgaca tttggctgcg cggaatggaa 409981 ggttataaag agacgattat tgaaattgaa gacacgggta tcggcattcc aaaagaggat 410041 attgagcata tttgggagcg attctataaa gcagatattt caagaacgaa cacagcatac 410101 ggtgaatacg gactcggtct ctcgatcgtc aggcagctcg ttgaaatgca ccagggcaca 410161 gtagaaatca agagtgaaga agggaaaggc acaaagttca tcatccgcct tcctttaacg 410221 gcaaaacagc aatagcatac agggcggcgc atcaactgat gcatccgcct tttttgcaca 410281 ccgcttcggt ttattgcgtg ctcccgaaaa caaagattgc gtgtttttcg ggttgggacg 410341 gcctataaac atgataaaat atgacataaa cagtttttga tgggagaggg tgaaggaatg 410401 aagagtgggg taattccttc ttcagcggtc ggtcaaaaaa ttaacgagtg gtacagatat 410461 atccggacat tcagcgtgcc ggatgccgaa gtgttaaaag ctgaaatcca gcaggaactg 410521 aaacacatgc agcatgattc caacttgctg ctttattatt cactaatgga attccggcac 410581 cagcttatgc tggattatct tgagccgtta gagaaattaa atatcgaaga ccagccaagc 410641 ctgtctgaat tatcaagaaa cattgacagc aaccaggcag atctcaaagg gctgctcgac 410701 tattacgtga atttttttcg cgggatgtat gaatttgata agcgggaatt tatttctgcc 410761 attacatact ataaacaggc ggagaaaaag ctctcctttg tcgcagacca tattgaacgg 410821 gctgaattct attttaaaat cgcggaagct tattattata tgaagcaaac gtatttttca 410881 ttgattaata taaaaaacgc ctatgaaatt tacgtggagc aggaaaccta taatgtgaga 410941 atcattcagt gccatttcgt cttcggggtc aacctgatgg atgaaagaaa tttcgaacaa 411001 gccgcacgcc atttcaaatt ggcgctcaac atggcccaag cagaacaaaa agcccagctg 411061 gttggaagag catactacaa tctcgggtta tgctattaca atcaagacct tctagaccct 411121 gccattgatt actttgaaaa agcggtctcc acatttgaaa gcagcaggat cgtcaattct 411181 ctcccgcaag cctatttttt aatcaccctg atttattata aacagggaaa acatgataaa 411241 gcttcggaat atcacaagcg gggctatgaa tatgctaaag aaacagacga tgcagactat 411301 gccgtaaaat tcgagttttt gcaatcccta tatctggatc agcccaatga agaaggaatc 411361 gaacgatgtt tccagtactt aaaaaataaa aatatgtacg ctgatataga ggatttagcc 411421 ctagaagtag caaaatatta ctatgaacag aaatggttta aactgtctgc ttcctacttt 411481 ctacaagttg aagaggcaag aaaacaaata caaaggagtg aaggtttgta tgaaattgaa 411541 atctaagttg tttgttattt gtttggccgc agccgcgatt tttacagcgg ctggcgtttc 411601 tgctaatgcg gaagcactcg actttcatgt gacagaaaga ggaatgacgt aagaacaagc 411661 cccttctcat tagcgagaag gggtttttct tttcaaaaaa acaccgcaag acatagtctt 411721 gcggtgccgc cttcatggag attacgttta tttagtagcc tcctacaaat gcagttccca 411781 caatgatcaa gaggataaat aacacaacaa tcaaagcgaa agaagttccg taacctgaca 411841 ttttgtgcac ctccttgcga gattgcttca gcaaatgctg caaaactgtg gcggacaggg 411901 tcccgcagag acggtcagca gcttagaagc cgccaacaaa cgcagtccct acgataatta 411961 atagaataaa caatacaacg attaaagcga aagaactgat gccgccgtaa ccgccgccgt 412021 tagagtatcc tgacataagg tttcacctcc ctatgaagga tactataaga tatgctgaac 412081 cgatccattt ggcagggata atagtggaca agagaaaaaa tgaagaattc ggctatatga 412141 aggtgatata aaaaaatagc gggcgctgcc gcccgctatt tatgtacgat taagagatca 412201 gcacgcccgc gaaaaattcc tggtataacg cttgaacggc ttttctttct tcggcttctt 412261 ttacgccaaa catcatgctc acttcagaag acccctgatt gatcatttcg atattcacct 412321 gtgcctctga taatgctttg gcggctcttg ccgttgtacc gacattgtgg cgcatcgctt 412381 cccctacaac cataatcagg gcgagatgat gctcgacgat gacttcatcg gcatgcaaat 412441 cctcttcgat ccgtttgatg acgctgcgtt cagtggcggc atccatttgc ccctgccgta 412501 aaatgattgt catgtcatcg attcccgatg gaacatgctc atacgtcaaa ccatgctcct 412561 ccaggatttg aagggctctg cggccaaaac cgatttctct gttcatgaga tacttgctga 412621 tataaatgct gcaaaaaccg gtgtcgctgg caatgccgac gacaggcccg tttgtgttat 412681 cccgcttgct gacgacgcgg gtgccttcgg ctgaggggtt gttcgtattt ttgatctgaa 412741 caggaatccc cgctctgaat gccggaatga gcgcttcatc atgaaacact gaaaaacccg 412801 cgtaggacag ctcccgcatc tctctatatg tcagctcgct gatttccttt ggattctcaa 412861 cgaaggacgg attgacagaa tacacagcgt ctacgtctgt aaagttttcg tacaaatcgg 412921 cttgtagtcc gttggcaaga atcgaaccgg taatatcaga accgctccgt gagaatgtga 412981 tcacatcgcc atccttgctg aatccgaaaa aaccgggaaa aatgatgagt ccgtcacgtt 413041 cccgaagacg atagaggttt tgataggatt caggaagaac ttgcgcgttg ccgggttcat 413101 ttgtcacaaa gaggccggca tccttcgggt ttacatattc cgctttgacg cctttataac 413161 ggaagtaagc ggcgatcagt ttggcattgt tatcctctcc gctggccttg actgcgtcaa 413221 ggtattgttc gggattgctt ttgtctcctt ctaaaagcgt aaacagatca tctctgattt 413281 tttcgataat gctttgcccc agctgaagct cattggcgat gagagcgtac cgttccacaa 413341 cagcttccgc cagttcaggt gcgctgcctg ttgccaaata ttgttctgca catgcgatta 413401 agagatcagt cactttcgta tcctcggcat agtgttttcc cggagctgaa acgactacag 413461 ctttccgtgc cggatctgag gtaacgatgt gaaacacctt gtcaagctgg gcgcctgaag 413521 caagtgagct gcctccgaat ttaacgacct tcatgtttac atctcctaat gtttaaaatt 413581 ttcacacaaa tttagtattt attatctctc tttcagtact gtaaatcaag ggggaatttc 413641 tttctcagga gaacatttgt atttttcacg aggaataatg ttaggtttgc tgaccgtatg 413701 cctgcgttat aaagataaat atggtaaaca gcctaacgtt ttgggatgga aaatggttag 413761 aatgattagt aaaattgata aatgactagg ttaatatttt taaagaatat tgactaaccc 413821 tataaaaatg gtaatatgta aatgataatg ataatcaatt actatatggc catattgttt 413881 tgagtccttg cggagtagga gatacgttct ttttgctgta aggatgtaag gaggcagcat 413941 gaagctacgt tacttattta ttctacttat catattagca gtcacatctg tatttatcgg 414001 tgtagaagat ctgtcgccgc ttgatctctt cgatttaagc aaacaagagg cgtcaacgct 414061 gtttgcaagc cgtttgccgc gattgatcag cattgtcatt gcgggattaa gcatgagcat 414121 ctgcggtttg attatgcagc agatcagcag aaataaattc gtgtcaccga cgacggcggg 414181 cacgatggat tgggcgaggc tcggcatttt aatttccttg ctgctgttta catccgccag 414241 tcctttaatc aaaatgctgg tcgcgtttgt ctttgccctt gcaggaaatt ttctgtttat 414301 gaaaatcctt gaaagaatca agtttaacga caccatcttt attccgcttg tcggtttaat 414361 gctcgggaat atcgtcagtt caatcgcgac atttatcgca tataaatatg acttgatcca 414421 gaatgtgtca tcatggctgc agggagactt ctctttagtc gtgaaaggaa gatacgagct 414481 tctttatctg agtattccgc tcgtcatcat tgcctatgtg tatgcggata aattcacatt 414541 ggccggtatg ggtgaaagct tttctgtcaa cctcggcctc aagtataaac gggttgtgaa 414601 catcgggctc attatcgtgt ccctgatcac gtctcttgtc attttgactg tcggtatgct 414661 gccgtttctc ggtttaatca tcccgaatat tgtatcgatt tacagaggag acaatctgaa 414721 gagcagcctg ccgcatactg tgctgttggg agcggttttt gtgctgtttt gcgatatact 414781 gggcagaatc attatcttcc cttatgaaat ctcgattggc ctgatggtcg gaatcatcgg 414841 cagcggcatt ttcctgttta tgctgttaag gagaaaagcc tatgcgtaac cagatgaaaa 414901 tagctttgct cgttggttta gccattgtat gtattggctt gtttttgttt tatgacttag 414961 gcaattggga ttacaccctg ccgagacgaa tcaaaaaagt cgctgccatt gtgctgactg 415021 ggggagcgat tgcgttttcg accatgatct ttcaaacgat tacgaacaac cgcatcctga 415081 cgccgagcat tttgggcctt gattctctct acatgctgat tcagactggc attatctttt 415141 tgttcggttc tgcgaatatg gtcatcatga ataaaaacat caactttatc atctctgttc 415201 tgctgatgat cctgttttct cttgttttgt atcagatcat gttcaagggt gaggggagaa 415261 atatcttttt ccttctgctt atcggaatcg tgtttggcac gctgttcagc agcctgtctt 415321 cttttatgca gatgctgatt gatccgaacg agttccaagt tgtgcaggac aagatgtttg 415381 ccagctttaa caatatcaat acggatttgt tatggctcgc gttcatcatc ttcctgctga 415441 caggcgttta tgtctggcgt tttacaaaat ttttcgatgt gctgtcgctc ggacgcgagc 415501 acgccgtgaa tttgggcatt gactacgaca aagtggtgaa gcagatgctg atcgtggttg 415561 cgattttggt ttctgtttca acagcgctag tcgggccgat tatgttttta ggccttctgg 415621 tcgtcaacct ggcgagagaa ttcctgaaaa catataagca ttcatactta atcgcaggct 415681 ccgttttcat cagcatcatt gcgctggtcg gagggcagtt tgtggttgag aaagtgttta 415741 ccttctcaac gacgctgagc gtcattatta attttgccgg cgggatttat tttatctact 415801 tgctgttaaa ggagaataaa tcatggtaga ggtcagaaat gtaagcaaac aatatggcgg 415861 gaaagttgtt cttgaagaga cgtcagtcac gattcaaaag ggcaaaatca cctcgtttat 415921 cggtcctaac ggcgccggca aaagtacgct gctgtctatc atgagccgcc tgatcaaaaa 415981 ggattccggc gagatttaca tagacggaca agagattgga gcatgtgaca gcaaagagct 416041 tgccaagaaa atgagcattt tgaagcaggc gaaccaaatc aatatcaggc tcacgatcaa 416101 agacctcgtc agttttggca ggtttccgta ctcacagggc cggctgacag aggaagactg 416161 ggttcatatc aaccaggcgc ttagctatat gaagctggaa gacattcaag acaaatactt 416221 ggatcagctg agcggcggac agtgccaaag ggcatttatc gccatggtca ttgcccagga 416281 cacagattat atctttctgg atgaaccgct gaacaatctg gatatgaaac actcagttga 416341 aattatgaaa ctgctgaaac ggctggtaga ggagcttgga aaaacgatcg tgatcgtcat 416401 tcacgatatc aattttgctt cagtctattc tgactatatc gtcgctttga aaaacggccg 416461 aatcgttaaa gaaggaccgc ctgaagaaat gatagaaaca tcagtgcttg aggaaatcta 416521 cgatatgacc atcccgattc agacgattga taatcaaaga ataggtgttt atttttctta 416581 atatatagaa gaggtgagga gcatgaaaaa gttcgcgtta ctattcatcg ctttggtcac 416641 tgccgttgtc atttctgcat gcggaaacca aagcacaagc agcaaaggtt ctgatacaaa 416701 gaaagaacaa atcacagtga aacaccagct cgacaaaaac ggcacaaaag taccgaagaa 416761 ccctaaaaaa gttgtcgtat ttgactttgg aagcttagat acattagata aactaggact 416821 tgatgatata gtagcgggcc tgccgaaaca agtccttcct aaatatctgt ccaaattcaa 416881 ggatgacaaa tacgctgatg tcggcagctt aaaagagcca gacttcgaca aagtggcaga 416941 attagatcct gatctgatca ttatttcagc aagacaatct gagtcttaca aagaattctc 417001 taaaattgcg ccgacgattt accttggtgt agatacagcg aagtacatgg aatcatttaa 417061 atcagacgct gaaacaatcg gtaaaatctt tgataaagaa gacaaagtga aagatgagct 417121 cgcaaacatt gatcactcaa tcgcagatgt aaagaaaacc gctgaaaagc ttaacaaaaa 417181 cggtctcgtc atcatggcga acgatggaaa aatcagcgcg ttcggcccta aatcaagata 417241 cggcctgatc catgacgtat tcggcgtggc tccggctgat caaaacatca aagcgtctac 417301 gcacggacaa agtgtttctt acgagtacat ttcaaaaaca aaccctgatt acttgtttgt 417361 tattgaccgc ggtacagcaa tcggagaaac atcatctaca aaacaagtcg tggaaaacga 417421 ttatgtgaaa aacgtaaacg cagtgaaaaa tggtcatgtc atctaccttg attctgctac 417481 ttggtattta tcaggaggcg gacttgagtc tatgacgcaa atgattaaag aagtgaaaga 417541 cggtttagaa aagtaaaacc aaaaagagcc tccgctaaat agcggggctc tttttttgtt 417601 aatcagcgtg ccggctgctg ttcggcaggg cgctgaggtt tctttaatgt gaatgagaga 417661 aggaagccga caagtgcaat gacggcagcc actataaaag cggcgttcat gccgtgcagg 417721 gcggcgtgct tcacatttgt cgtgcctgca tgtgccgcct ggttgctcat cacggaaacc 417781 aatagtgcgg ttccgatcga gccgccgact tggcgaatcg tgttgttcat cgcagttccg 417841 tgcggaatca agtggcgcgg cagcgcattg attccggctg ttgtcaccgg catcatgatc 417901 atggcggtgc ctaagagacg aacggtgtat aaaacgacaa tccaagcgag tgacgtatgg 417961 tcagtcagct gcataaacgg cagagatgtc aggaagatga tgcagaaacc ggcaatcgcc 418021 agccctcttc cgccgacacg gtcaaaaatt ctgccgataa tcggcgacat aaagcccatc 418081 acaacggctc ccggcaggag cataagccct gtatcaaaag ctgtgacgtc tctgacattt 418141 tgtgtataaa gcggcaggat ggtttccgta ccgatcaata atgcaaagac gagggttccc 418201 agcagtgttg ttaagctgaa aacgccaaac gtgaagacgc ggaattccag catcggtttt 418261 ttaagcttca tttgtcttgt gataaacaag agcagcgcga tgacacccac cagcagtgaa 418321 atcaagacgg ttgaactgga ccagccataa gagccgacgc ttgagaagcc gtacagaagg 418381 ccgccgaacc caaatgttga aaggatgact gataaaatat caatctgtgt ttttcttaaa 418441 gtcgtcacgt ttttcatcag gatgctggca agaatcaaat caatcacagc aaacggaaga 418501 ataatataaa acaatgatct ccaagagaaa gcttcgacag cccatccgga aagagtcggt 418561 ccgatcgcag gcgcgaatga gatgaccaat ccgaccatac ccatagcctg gccgcgcttt 418621 tcaatcggaa agattgtcag gaatacagtc tgcatgagcg gcatcataat gccggctcca 418681 gccgcttgaa tgatacgcgc tgtcagcaga accgggaagt tcggcgcgaa cgctccgacg 418741 actgttccgg cagtgaaaat gctcattgct gtgatgagca gcgcccggct tgtgaatttc 418801 tcaattaaaa acgcggtaat cggaattaaa atcccgttgg ttaacataaa tgatgttgtc 418861 agccattgtg cttggttggc atcgacattg aaatccctca tgatatgggg aagtgcagta 418921 atcaacaatg tctggttcaa aatcgccaca aacgctccgg ctaacaaaat gccgacaatg 418981 acagaacggt taaaaggttt ttgttcaata cttgtgttca atacatatcc cttcttttct 419041 ctaagtaatt aacagtgttt ttaacatgga aacgggctgt gttaaaacac cggtttgttc 419101 cagatagcca atcagtgatt tgagtaaaaa agcgcggggt tcttccttct tcgcttcttc 419161 ctccagcata gcggctgcgg atgtcagttc atctacgtca tagtccgcgg cggacaggga 419221 agagatgcct ttatgtaatt ccttcaggct ttccgataat aggactgatt tatcctttgg 419281 cttgtaggag gatgctgaat gaatataaag ctcgatggct tcgggcggaa gaagagactg 419341 gcgggtttcc ctgtttttga taatctgatt gagggtgctg atgataaact ctgcgatcgg 419401 gtcaagctca agcggttttt cctcgatttt gatcagcatt aaaaactcac gcatcatgcc 419461 gtgaagaatg ataaccaaat cccacacaaa cgggagaatg gtttctccat acgcctggat 419521 cagcgaatcg cggtgccagc agataatcgt cgatctggtc tgatggatat gctgtttgac 419581 ccggtcattg tgcagcttgg ggtttccgta ggtcagcata ttgaaaaact gctgattccg 419641 cctgaagccc tccagttcca ttttgacctt ttgcgtcaaa cgctcctccg gtgtaagtgc 419701 tgtattttcc tgaagtcttg aggccgcggc caccatttgc ttctggttaa atgacagcag 419761 ctccaaaagc agatcttctt tagattggaa cagcttatat atcgaagctt ttgacatctt 419821 acattcttct gcgatcgcct gcatggaaac cgacgtaaaa tccttttccg aaaaaagctt 419881 tcgcgcggct aacaagatat ctgttttttt atcaagcatc tcatggcttc cttctttctt 419941 gaacattaga aaacccattg gttcacagaa aaccaatgag taacaatgaa aaaattttac 420001 cagataaaca aaatagaagt caatggattt taaccgggta aatgaaaggc ctgccggaaa 420061 atccgacagg ccgaataaga gcttattttt caactttaaa tccttgtttt tcaagcattt 420121 cacggatgtg cggatagtac aggcgctcat agtaggaagc gatgctctgt gaccagtttc 420181 ttgtttcttt tccgtttgtc cgtttattca tgtattcaga catctgttcg tcgtatgcct 420241 gaatgtgaga cgtcagctca tcctgattca aataagtttc ctgatgattg acagcttcct 420301 gcggcaagcg cggttttttc gctgaacggt cggcaggatg cccaatgaca aggccggata 420361 aagggaacac gtatttcgga agctcaagca gttcgatcag ctcttgaggg tttccgcgaa 420421 ctgcaccgat cggaactgtg ccaagtccga gtgactcagc cgctgctgtt gctgtgccga 420481 gggcaatacc agcgtctact gcgccgacaa gaacagattc caatccattt gtgatttcca 420541 ttttgaaatc atgcagatct tcaagcgcaa ttttggcccg gttaaaatct gcgcagaaca 420601 gcaggaaaac aggagcttga tcgatccatg gctggccgcc tgccagctcg gagattttct 420661 ttttgcgctc tttatcctgg actgtgatca cagtcacttg ctgtccgttg atagaagaag 420721 gggctgattg caccgcttca atgatttggt ccaattgctc ctgagctaca ggctcatctg 420781 tgtagctgcg aatcgagcgg tggtctgtta aagatttaat cacttcattc atatgagaca 420841 cccttccttt actcgctaag ctctgtgcgg acaacatcaa gaggagcgct cagcagttct 420901 tttccttttg cgacaaaccc ttggaaatgc gcagtttcgt tatggaattt cattgccgct 420961 tcatctttcc atttttcaag catgacaaat gtattttctt cgcctacttt ttcgaatagg 421021 tcgtattgcg cgttgccttc ctcagctctt gaatgctgaa caagtgattg agcctcgctc 421081 aaaaattcct cgcgtttttc tggttttact ttgatgtaag cttgtaatac gatcatgtaa 421141 atctcctccg tcgttatgcg aatttattgt tcgaatttca tcgaactaaa tgtaacatgt 421201 attctaaatg aggtaaagga aaaaccctta tatagtaaaa ttgtcattct aattgttgta 421261 tgatacattt gtgtcatgaa cattccaaac catccagaaa cagaaacatt gcagctgaca 421321 aaggttcttc atgcacttag tgatccgctt cgtttagagc tcgtcaagca attagctgaa 421381 gcaaaagaaa aaacgtgcag cacctgtgca gatgtgcagg ttgccaaatc gactttgtcg 421441 catcatttta aagttttgag agaatcaggc atcgctcaag ttcggataga aggaaagcgc 421501 cggtattatt cgcttcgcgc tgaagacctt gaaaaggcat ttccgggact gcttgaagcc 421561 gtgctgaatg tagaccagga ccgctggtga atcaatcccc tgtaacgggg atttttttat 421621 gtccgtaaac cgctttgaaa agccgctgca caccctcctg aatatcttct tccttcagcc 421681 gtgcaaagcc gataatgaga gcaggcctgc ccgtttgccg cttgttttcc ttcaagttaa 421741 atcggctcat tccgaatatt tcaagctgca gcccggcagc atgtgacagg atgtcttgtt 421801 cggtgcgcct ggtatcaaat tcggtaacaa aatgcagccc cgcatttgcc ccttttacgg 421861 taacctctcc gctgaactct gcttctaaag cggtgatcag gcgttctctc ttttctttat 421921 aatgctgctt catttttttt atatgcttct gatattcacc agactcgata aattcctgca 421981 gggtgagctg tgtgagtgat gagcaagtct gcagatcata gccccgctgt ttgtatgccc 422041 tcaacagctc aggcggcaac accatatagc tgatccgtaa gccggggaga agggactttg 422101 aaaaggttcc catatagatg acattttgaa aacggtcgag gctttgcagc gccggaatac 422161 tgtctacatc atatgtgaat tcactatcat aatcgtcctc aatgatatat cggcgcggct 422221 cctcggctgc ccagttcagc agctgaattc ttctggatac aggcataatc gttccggacg 422281 gaaactgatg cgacggggtg gtcaccagca catctggctg ctgtctggtg atttcagcaa 422341 tcgacatgcc tttttcatcc agcatgatcg tctttacttg ttttccggca ttcttcaaaa 422401 gctgatacat gcgcctgtag ccaggctcct ccatcgcata cacggcttcc ttgggtaaaa 422461 gctcagtcaa cagctgcatg agcacctgtg tgcctgcccc tatgatcatt tgttccggcc 422521 tgcattttac acccctcgtc agggaaatga gcctcgtaat ggccgctctc acttcatata 422581 tcccttgcgg atgtgacata tcgccgagcg tgcggtatga gcgggaggcc gctttttgct 422641 cgcagcggaa ccagcttttg atcggaaaat ggtctgtatc ggaactcatg tgtgaaaacg 422701 atatccaatc gctctggtcg atgtgaatct cttttaggtc atccggcagt gcaaatggag 422761 ggtgctcctc ggcggaaaac atgtctagtt cctccacgaa gaaacccttt cgttcaatgg 422821 cgtacaaata cccctcagcc agcagctgct gataggctga attcactgaa tttacgctga 422881 ccttgagatt ttcagccagc tcccgcttgg agggaacctt cgagtgcggc agcagattgc 422941 ggctgaggat ttcttttttc agcttttgat aaatttgctg atagatataa tcggcttgtt 423001 ctgaacgatc gagtgtaatc gtgatatcca ttttgtagtt tctccttctg ataccatcaa 423061 aaagttataa ttggtacttt tcatcatacc aaagagaagt cagaatgata agaaaatacc 423121 gacaggggga tattcacatg agtcaaacaa cagcaagcat cacaactgca caatggcagc 423181 aaaaacggga tcaatttgtg tcaaaaggtg tgagcaacgg caaccgcagt ctggcggtca 423241 aaggagaagg ggccgagctg tacgatctgg atggccggag atttattgat tttgcaggcg 423301 ccatcggcac gttaaatgtc ggacactcgc atccgaaggt ggttgaggct gtgaagcggc 423361 aggcggagga gctgattcat cctggtttta atgtcatgat gtacccgact tatatcgaat 423421 tagcagaaaa actgtgcggc atcgcgccgg gcagccatga gaaaaaagcg atttttctta 423481 actcaggggc agaagcggtc gaaaacgctg tgaaaatcgc cagaaagtat acaaagcgcc 423541 aaggcgttgt ctcgtttaca cgcgggtttc acgggcgcac gaatatgacg atgagcatga 423601 caagcaaggt aaaaccttat aaattcggtt tcgggccttt tgcgccagag gtttatcaag 423661 cgccgttccc ttattattat cagaagccgg ccggcatgag tgatgaaagc tatgacgata 423721 tggtcattca agcattcaat gatttcttta tcgcttcagt ggcgcctgaa acggtggcgt 423781 gtgtcgtgat ggagccagtg cagggagaag gcggatttat tattccttcg aaacggttcg 423841 tacagcacgt cgcttcattc tgcaaagaac acggcattgt ttttgttgct gatgaaatcc 423901 aaaccggctt tgccagaact ggcacttatt tcgcaattga gcactttgat gtagtgcccg 423961 atctgatcac ggtttctaaa tcgcttgcgg caggcctgcc attaagcggt gtgatcgggc 424021 gtgcggaaat gcttgatgcg gcagcgccag gggagctggg cggcacgtat gccggcagcc 424081 cgctcggctg cgcggcggct ttggcagtct tggatattat cgaagaagaa ggactgaatg 424141 agcgatctga agaaattggc aaaatcattg aagacaaggc gtatgagtgg aaacaagaat 424201 tcccgttcat cggtgacatc cgcagactcg gggcgatggc cgcaatcgaa atcgtcaagg 424261 atcctgacac gcgtgagcct gataagacaa aagcagcagc gatcgcggcc tatgcgaatc 424321 aaaacggatt acttttgctg acagcgggaa ttaacggtaa tatcatccgc tttttgacac 424381 cgctcgtcat ctcagacagc ctattaaatg aagggctcag catcttggag gcgggcctgc 424441 gagcttaatc attggaaaga aaatggccgg gtctgctatc attttaagta atcatgaaaa 424501 gaaaggaatg ttcaatatgc cagatcaatt aacggtctac aacccggcta cgggcgagga 424561 gatcaaaacg attcctcagc aatcagccac agaggtagaa gaagccattg aacgttcaca 424621 tcaagcgttt aaaacgtggt ctaaaacatc agcgaacgaa agaacgtctc ttttgaaaaa 424681 atggtatgag ctgattgttg aacataaaga agagcttgca gatttaatta caaaggaaaa 424741 cggaaaacca taccaggaag cagtcggcga ggtactttac ggcgcaggct atatcgaatg 424801 gttcgcagag gaagcgaagc gtgtgtacgg aagaacggtc ccggccccga caactggtaa 424861 acgaattgtt gtcacacgcc agccggtcgg ccccgttgct gctatcacgc cctggaattt 424921 cccgaatgcg atgattacac gcaaagcggc gcctgctctt gccgccggct gtacatttat 424981 catcaagccg gcgccggaca caccgctgtc tgcttatgaa ctagcgcgcc tcgcatatga 425041 agcgggcatt ccgaaggatg ttcttcaggt tgtgatcggc gatggagaag aaatcggaaa 425101 tgtgttcaca agcagtccga aaatccgcaa aatcacgttc acaggctcaa cacctgtagg 425161 gaaaatcctt atgaaaaaca gcgctgacac cgtaaagcac gtctcaatgg agctcggcgg 425221 acacgccccg ctgatcgtag atgaagatgc ggacattgac cttgccgttg aacaggcgat 425281 ggcgtccaaa taccgaaacg ccggccaaac ctgcgtatgt gccaaccgcc tgatcgttca 425341 tgaatccatt aaagatgaat ttgctgcgaa actgagcgag caagtgtcta agctgaaagt 425401 cggaaatgga cttgaggaag gcgtcaatgt cggcccgatt atcaacaaac gaggcttcga 425461 aaaaatcgtc agccaaatag atgatgcggt tgaaaaaggc gcgaaagtga ttgctggggg 425521 cacatatgac cgaaacgatg acaaagggtg ctactttgtg aatccgacag tgctcaccga 425581 tgtcgatacg tccatgaaca tcatgcatga ggaaacattc ggcccggtcg ccccgatcgt 425641 cacgttttct gatattgatg aagcgattca gcttgccaac gatacaccgt atggcttggc 425701 tgcttacttc ttcacagaaa actaccgccg cggcatctat atttccgaga atctagagta 425761 tggcattatc ggctggaatg acggcggacc gtcagcggtt caagcgccat tcggcggaat 425821 gaaagaaagc ggcatcggcc gtgaaggcgg ttcagaaggt atcgagccgt accttgaaac 425881 aaaatatttg tccatcggtt tataaaagaa tgcacgctcc tgagagctgc cggattttcc 425941 ggcagctctt tttgtgttcc ggcgaataat cacaacaatt ccagccaaaa taacagcaaa 426001 tacattttga aagaaggttc cccaacaatg gatttattat tggctcttct cccggctttg 426061 ttttggggga gcattgttct cttcaatgtg aaattaggcg gcgggccgta cagccagaca 426121 ctgggaacga cgatcggggc actcattgtt tctatcgtta tttacttttt tgttcagccc 426181 gttctgtccc ttcgcatttt tattgttgga atcgtatccg gcttattttg gtcacttgga 426241 caggccaacc agttgaaaag cattcaattg atgggcgtgt cgaaaacaat gccgatttcc 426301 acaggaatgc agctcgtttc cacctcgctg ttcggtgtga tcgtgttccg cgaatggtca 426361 acaccgattg cgattacgct tggcgttctc gctttgatct ttatcattgt gggaatcatt 426421 ctcacgtcct tggaagataa gaatgataaa aaagagggcg agccaagcaa tttgaaaaag 426481 ggcattttga ttctccttgt ttcgactctt ggttatttgg tttatgtagt cgtggctaga 426541 ttattcaatg tgtccggctg gtccgcgctg ctgccacagg caattggcat ggtggtcggg 426601 gggttagttt taacctatag acacaaaccc tttaacaagt atgcgatcag aaatattctc 426661 ccagggttaa tctgggcagg cggaaatatg tttttgttta tttctcagcc gcgagtcggc 426721 gttgcaacga gcttttccct ttcacaaatg ggaattgtca tttctacgct cggcggtatt 426781 ttcatcctgc gtgaaaagaa aacgaaacgc cagctaatag caattgcgat cgggattatc 426841 ctgattattg ccgccgccgt attcttagga atcgccaaaa caaattcata acaaatggag 426901 gaggatgtat atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc 426961 agggctcgga aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa 427021 ctattatagt aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg 427081 tgaagctgtt gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca 427141 aacggcaatt aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa 427201 tcctgtgcca tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt 427261 aacgggtgcc tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa 427321 gggaaatgtc attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca 427381 ctatgcggca agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc 427441 gccgaagggc attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc 427501 tgaaaaattc gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata 427561 tatcggcgaa ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag 427621 ctacgtcaca ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca 427681 ggcaggccgc ggttaaacat aaaaagcgac ccagacatga catctggatc gctttcttta 427741 ttaggcacgc tttttcttta caagtgctgc tacagataaa ataatggcag ccgcagacag 427801 caccatcgct gtaatgtcta gagctgaaga acctgagttt tcggaatcgt cttctgtttt 427861 cgtggcgccg tgctcatctg tcacttgctt tgcagacgtg atgtttgtaa tggaatgagg 427921 tgtatcggca tcctcgtcac ctgtccactc aacaatgctg ccgtctttgt aatattggta 427981 tgcgtcccaa gcagcttcct ccgctttgtc agggtttttg gcaacaaagg taaactgctg 428041 gaactggcct tcctgaatgc ctccgtcagt cgcctcccat gtcacggata ctgatttgtc 428101 atcatgtttt tgagtggaaa ccttccagcc cggaattggc tcatattgct ggaattcaac 428161 atccttcggc attttgagga caaccttcgt tgtcggcaga tttttctcag aaggaacctt 428221 cattgtatac gtttcccaag agcctgcagc agactcagcc ggttttacag aaacatgcgc 428281 gctggcaggg gccgtaaaga ataagaggga gccgacaata gccggacata gtgtcaatgc 428341 gatttttttc aacaacgtaa acactcctta attggtcttt gtaaacatga tattgatttc 428401 gttaaagtcg ccggtcaggc cgtggacttt gatcttccag tttccttttt cattaatcga 428461 caggttttga tcttggaaga cgccttttgt tttttctttt aatgtaaagg tgcttttgtt 428521 ttcgctgcct gacaggcctg ttttataaac ggttaacgtg atttgctgga tgtttttcac 428581 gggatcaccg ttatggtcgg tgacccgcag ctcaaaaaca ttttttccag gctggtttgg 428641 gctgatgctg agagaaacgc tttgtccgtt ctctatcgct ttggtttggt agaacggttc 428701 cggcgctggc tcaggcgggc ttggcaggct tgtaaacacg gccgctgtga tcaatacagc 428761 gatgccgatt gcccactccg ctttcaacgt tcggctgatt cctgtgcggc gctgctttct 428821 ggtaagcaga aaatgaattg cgcctaagac cagcatgaaa acaaacagcc cgcttttcac 428881 taaaagagct tgtccgtacg ctgtatggaa cagtgaatcc attgaacgaa tgatgaaaaa 428941 tccattgagc aagcctgaaa acaaaatgac gccgactgca gtgagcgccc atggggagaa 429001 ccgtctgacc gtctcccacg cgagcgtttt gtcaggctgc ctccattctt ttgagagcag 429061 caaaacgagt gccgctattc cgccgaccca gatggaagcg gaagttaaat gaaggaaatc 429121 catcaaaatg ccgaccgttt tttcttcaac gacagcagca tgcccggtaa acgccttggc 429181 aagcaggaga ccgaaaaaga aaatgagcgg cgctgtccaa tagccaaagg atgaaaagcg 429241 gtttttccgt atcgcaggga tgacagacag tgcgagcagc acgaacagcg cagcctgtat 429301 gatccaaatg gagccgcctg ctgtctcaaa cagtgtttct ctgatgtagc ccggctggaa 429361 tgcgctgccc cagccgccgc ctgcgttcgc ttttgtctga atcggaagct gaagcaaaag 429421 cgccagcccc aatgctgcga tcgagccggt caggatacgt ctcgtccgtt tgacgagctg 429481 ttctgatttc cctttatacc agaaaagatg gaagaaaacc gttccgataa acagagataa 429541 ggctgtatac agaatcgcgc gatctgctgc tgttcccgga ttcagcgctg aatcggctgc 429601 tttttggctg ctgaatccgc catccgcttt cccgatactg aacggaatga cgccggaaac 429661 aggatgtcca tccgcggata cggcattcca ttccgctctg tacacatctt taggcagatt 429721 cttcttcagc ttcactgtca tgatgtgatg attatctttt ttgatttcag tcttgtccgt 429781 atccacacgg tcgccgtttg aattatagac tttaatgtaa tgaaaccctt cttcaaccgg 429841 ttcattaaat tcgatttcca cctgcgcagg ggcgcttttt aattcgctgt tttccccagg 429901 tgaagatttg acaatatagg cgtgagcaaa gcttgttttc ggcaggaaaa caagaaaaag 429961 cagaaggatg atccaccatc tgtttcgctt catcactcag acaccacctt ccgctgtatg 430021 tgttgtgtta tttcttggtg caggtgcagc gtttctttcg gtcttgaagc atgtcttcca 430081 gcgcttggtc gaaagtgcag acggctccgc cgaatccttt ttgaaatcgt tcggcatggt 430141 caagtgtcgc aaacggaatg gcctgcggct ggcagcagtg caggtttaat tcagcattta 430201 cgacgaaata agccgaaccg gcactgacgg ttgtctgtaa cagaaaatct ctgcaaatca 430261 agtgtgaaac ctcttccgtt ttatccgcgt aacgcaaaaa cgcgcaatgt gcgcagcata 430321 gctgttcaat gtcttggttt accgtaatca gctgaaccga atgagcttga ttgacgggct 430381 tcaagcaata gctgcacata tgatctgttt gaggtgttcg gacggggagc gtgatgccgc 430441 cggccgtttt aatgacctga tttgactgaa ccagctgatt gacatctcta tataccgtca 430501 tttccgaaac gccgaacctt gcgctgatgt cagaaattct aagcgagcct tcttctttca 430561 gccacttcag tatgtgttgc tgtctattaa tcggaagcat tcatacaccc tcttcattaa 430621 gatctattta agcgtagagg attttagaga cggagacaag taagtggatg ataaaaaatg 430681 tgaaaatgtg ttgaacagca acaaaacgaa acagaaggga ctctggtata atagacagat 430741 ggaatagaaa gtgaggaata ccctatgaaa gaaacaccat gcccgaactg cggcaaacct 430801 ttgacaggcg atatggtcag atcatcaaat gtgccttgtc aatttcgctg cggccactgc 430861 cgggaacggc tttatgaata taaagtttca gctccgatta tgctggtatc attagcggcc 430921 atcgtgctgc ttatttatct tttgatgctc ctccgcaatg cggcaggctc agtgctgcca 430981 gctgtacagc acgtgccgat ggctgtattt gcgcttgtgt gcgcgtatcc cgtttttatt 431041 gtgagtgagc ggatgattgc aaagtacgtg attcaaaatg gcaacatcat ttatagagga 431101 aagagaaaag gctcctgaaa ccaggagcct ttttattttt aaaaaattgt cacagtcatg 431161 tgccaaagtc ctctttactt tcaattgtat agggactgta agcgttttaa catagagtca 431221 aagggaagca tcattctctg aacatatttt tgtatcttac agcgacaaac aaaacaggga 431281 gggtttatat atgcagcagc aagaacagca gcaaggcggc atgaaagtga aagtgcaacg 431341 ctttgggagt tatttgagcg gaatgatcat gccgaatatc ggcgcgttta tcgcgtgggg 431401 tatcattacc gcgctgttta ttccggcagg atggtttccg aatgaacagc tgaacacgct 431461 ggtcagcccg atgattacgt atttattgcc gcttttgata gcgtatacag gcggaaaaat 431521 gatctacgac caccgcggcg gagttgtcgg agcgacagcg gcaattgggg tgattgtagg 431581 atcggatatt ccaatgtttt taggcgcaat gattatgggt ccgcttggcg gatacctcat 431641 taaacagact gataaattat tcaaggataa agtcaagcaa ggctttgaaa tgctgatcaa 431701 caactttacg gcagggattg tcggcgcggc tttaacgatt ctcgcgtttt acgccatcgg 431761 cccggttgtc ttgacgctaa ataaattgct ggcggctggt gtggaagtca ttgtacacgc 431821 taatttactg ccggtagcca gtgtttttgt agaaccggcg aaagtgttgt tccttaacaa 431881 cgccataaac catggaatct taagcccgat cggaatcgag caagcatctc aaacaggaaa 431941 atcaattctg tttttagtag aagcaaaccc tggaccgggg ctcggcattt tgctggccta 432001 catgttcttt ggcaaaggat cttcaaaatc aacggctccc ggtgcggcga tcatccattt 432061 cttcggaggg attcacgaga tttacttccc gtacattctg atgaaaccgg ccctgattct 432121 cgcagccatt gccggcggag caagcggact cttaacattt acgatcttta atgccggact 432181 tgtcgcggca gcgtcaccgg gaagcattat cgcattgatg gcaatgacgc caagaggagg 432241 ctatttcggc gtattggcgg gtgtattggt cgctgcagct gtatcgttca tcgtttcagc 432301 agtgatcctg aaatcctcta aagctagtga agaagacctg gctgccgcaa cagaaaaaat 432361 gcagtccatg aaggggaaga aaagccaagc agcagctgct ttagaggcgg aacaagccaa 432421 agcagaagaa gcgtctgagc tgtctcctga aagcgtgaac aaaattatct ttgcgtgtga 432481 tgcgggaatg ggatcaagtg ccatgggggc atccatctta agaaacaaag tgaaaaaagc 432541 ggagcttgac atcagtgtga ccaacacggc cattaacaat ctgccaagcg atgcggatat 432601 tgtcatcacc cacaaagatt taacagaccg cgcgaaagca aagctgccga acgcgacgca 432661 catatcagtg gataacttct taaacagccc gaaatacgac gagctgattg aaaagctgaa 432721 aaagtaatct tatagaaaga gagtgattgt catgcaagta ctcgcaaagg aaaacattaa 432781 actcaatcaa acggtatcat caaaagaaga ggctatcaaa ttggcaggcc agacgctgat 432841 tgacaacggc tacgtgacag aggattacat tagcaaaatg tttgaacgtg aagaaacgtc 432901 ttctacgttt atggggaatt tcattgccat tccacacggc acagaagaag cgaaaagcga 432961 ggtgcttcac tcaggaattt caatcataca gattccagag ggcgttgagt acggagaagg 433021 caacacggca aaagtggtat tcggcattgc gggtaaaaat aatgagcatt tagacatttt 433081 gtctaacatc gccattatct gttcagaaga agaaaacatt gaacgcctga tctccgctaa 433141 aagcgaagaa gatttgatcg ccattttcaa cgaggtgaac tgacatgatc gccttacatt 433201 tcggtgcggg aaatatcggg agaggattta tcggcgcgct gcttcaccac tccggctatg 433261 atgtggtgtt tgcggatgtg aacgaaacga tggtcagcct cctcaatgaa aaaaaagaat 433321 acacagtgga actggcggaa gagggacgtt catcggagat cattggcccg gtgagcgcta 433381 ttaacagcgg cagtcagacc gaggagctgt accggctgat gaatgaggcg gcgctcatca 433441 caacagctgt cggcccgaat gtgctgaagc tgattgcccc gtctatcgca gaaggtttaa 433501 gacgaagaaa tactgcaaac acactgaata tcattgcctg cgaaaatatg attggcggaa 433561 gcagcttctt aaagaaagaa atatacagcc atttaacgga agcagagcag aaatccgtca 433621 gtgaaacggt aggttttccg aattctgccg ttgaccggat cgtcccgatt cagcatcatg 433681 aagacccgct gaaagtatcg gttgaaccat ttttcgaatg ggtcattgat gaatcaggct 433741 ttaaagggaa aacaccagtc ataaacggcg cactgtttgt tgatgattta acgccgtaca 433801 tcgaacggaa gctgtttacg gtcaataccg gacacgcggt cacagcgtat gtcggctatc 433861 agcgcggact caaaacggtc aaagaagcaa ttgatcatcc ggaaatccgc cgtgttgttc 433921 attcggcgct gcttgaaact ggtgactatc tcgtcaaatc gtatggcttt aagcaaactg 433981 aacacgaaca atatatcaaa aaaatcatcg gtcgctttga aaatcctttc atttcggacg 434041 atgtgacccg cgtagcgagg tcacctctca gaaaactggg agaaaatgat agacttgtag 434101 gcccggcaaa gaaaataaaa gaaccgaatg cactggctga aggaattgcc gcagcactgc 434161 gcttcgattt caccggtgac cctgaagcgg ttgaactgca agcgctgatc gaagaaaaag 434221 gatacagcgg cgtacttcaa gaggtgtgcg gcattcagtc ccatgaaccg ttgcacgcca 434281 tcattttaaa gaaacttaat caataaccga ccacccgtga cacaatgtca cgggcttttt 434341 ttactatctc gcaatctagt ataatagaaa gcgcttacga taacagggga aggagaatga 434401 cgatgaaaca atttgagatt gcggcaatac cgggagacgg agtaggaaaa gaggttgtag 434461 cggctgctga gaaagtgctt catacagcgg ctgaggtaca cggaggtttg tcattctcat 434521 tcacagcttt tccatggagc tgtgattatt acttggagca cggcaaaatg atgcccgaag 434581 atggaataca tacgcttact caatttgaag cagttttttt gggagctgtc ggaaatccga 434641 agctggttcc cgatcatata tcgttatggg ggctgctgct gaaaatccgg agggagcttg 434701 agctttccat taatatgaga cccgccaaac aaatggcagg cattacgtcg ccgcttctgc 434761 atccaaatga ttttgacttc gtggtgattc gcgagaacag tgaaggtgaa tacagtgaag 434821 ttggcgggcg cattcacaga ggcgatgatg aaatcgccat ccagaatgcc gtgtttacga 434881 gaaaagcgac agaacgtgtc atgcgctttg ccttcgaatt ggcgaaaaaa cggcgcagcc 434941 atgtgacaag cgccacaaag tctaacggca tttatcacgc gatgccgttt tgggatgaag 435001 tctttcagca gacagccgct gattatagcg gaatcgaaac atcatctcag catattgatg 435061 cgctggccgc tttttttgtg acgcgtccgg aaacgtttga tgtcattgtg gcgagcaact 435121 tgttcggtga tattttaacc gacatcagct caagcctgat gggaagcatc ggcattgcgc 435181 cttctgcgaa catcaatcca tccggcaaat atccgtccat gtttgaaccg gttcacggct 435241 cagctcctga cattgccgga cagggccttg ccaatccgat cggccagatt tggacagcga 435301 agctgatgct cgaccacttc ggagaggaag aattgggggc gaaaattctg gatgtaatgg 435361 agcaagtgac tgccgacggc atcaaaacac gcgacattgg gggacaaagc acaacggctg 435421 aggtcactga tgaaatctgt tcgcgcttaa gaaagctctg atgaatcagg ccggtggcag 435481 atggctgccc cggcctgtcc atttccttac gaaaatttcc acgaaagtct aaccaagcag 435541 atccaaatgc tgtataataa tttggaattc ttaggaaagc atcgggtgaa ggaagttgaa 435601 tgcaaaaaca atcacgttaa agaaaaaaag aaaaatcaaa acgatcgttg tactcagtat 435661 cattatgatc gcagctctca tttttacgat cagattggtg ttttacaagc cttttcttat 435721 tgaaggatca tcaatggccc caacgcttaa agactcagaa agaattctgg ttgataaagc 435781 agtcaaatgg actggcgggt ttcacagagg agacatcata gtcattcatg acaaaaagag 435841 cggccgctca tttgtcaaac gtttaatcgg tttgcctggt gacagcatta aaatgaaaaa 435901 tgatcagcta tacataaatg ataaaaaggt ggaagaacca tacttaaagg aatataaaca 435961 ggaggtcaaa gagtcgggtg taaccttaac aggtgacttc gaagttgagg ttccttccgg 436021 taaatatttt gtgatgggag ataaccgtct caattcactg gatagcagaa acggaatggg 436081 catgccttct gaggacgata tcatcggtac tgaatctctc gtcttttatc cattcggtga 436141 gatgagacag gcaaaataaa atgcaatgca aaaagaacat ggaacatgac ggcaccgata 436201 ataaagcgcc gtgcacgttt aaaaaaatga tgatgaaacg gtgcggagcc ggctttccgc 436261 cccgtttttt atgatagaaa gcgttttgaa gaaaagggcc ctgttgaaat aaacagaatc 436321 aggattggcg aagccgtgaa gcgcatcgaa ttggtaaatc tcaagatggg tatgctgttt 436381 ttcccgcagt tttttgataa gaagcgctac gtcaaacgac ggctcataat tagggaaaaa 436441 caataggacc gggcaggctg gcatgtgatg aagagagtcg cgtatccggg aaccgtaata 436501 acaaaccgat ccgctcacct caggcatact gctgcatttc catgcgatag tagcccccac 436561 gctgaatcca atcacaaaga tgtgccgtcc ggcgttttgc ctgatcacat tctggatgat 436621 ggtttctccc gttttcagcc tttcgtgttt tgtaaattgt tcgtatgccg ttttttcttc 436681 tttcagtgtg tagacttcat cctcgccgag caggttgggc gtcaacacat catatccagc 436741 cattttgatc agccggccca tctttttcat atggctgttt acaccatata tttcgtgtgc 436801 gagaatgaca agcggttttg ggaacataac ggcctccttt tgtgtttttt ccattatatc 436861 ctatcgtttc actttaggct gagatataat ggtcaaaaaa aggagatata aaatgaactc 436921 attatctttg cctcaccgct atccattttt gtttattgat ggcgtgacgg atagcgagcc 436981 cggcaaacat gcggcagctt ataagctgat tagtgagaac gactggttta tcactgatac 437041 gcaaacagaa atgccgtttt cacttgtgat tgaagcgctt gcgcaaaccg cggcttttac 437101 aggaattaca gatgagaaca gcttgggatt attgtcttcg gtgaagaaag cggaaaagct 437161 gggagaagct gtgcctggtg accggcttga tcttacgttt gaagtcacgc gcaatcggcg 437221 cgggtttgtg ttcggacatg ccaaggcatc agttggagag cagcctgttg ctgaagctga 437281 aatcggcatc tatattgaaa aatgaaaaaa acccttcaca acattttgtg aggggttcta 437341 ttttgtgtcg taatcccgtt cgctttgaga gttatctctt tgctggcgtt tgtgtttttc 437401 atcattcata ttttccttca gctcttcatt aggaatcgga tcggttaagt cgttgtgctc 437461 ggggttttca tttggtttgt tttgctgttt tttttctgtc atgtttgatc acctcaccgt 437521 ttgttttcct cttattcatt ctcctcaaac ataggaaatc gcttttttgt cccgctgggt 437581 ataatgtatt agaatagaga gaagcacaac aaaaagataa agagaggtac atatatgtct 437641 gttcaaagag aagatgtaga tatcaagctg atcgcaattg atatggatgg tacactgctg 437701 aacgacgagc agctgatctc ggatgaaaac cgcaaagcca ttcgtgaagc ggaggataaa 437761 ggtgtgtatg tggtgatcag cacgggccgg acgctgatga cgtgcaggga gctggcggaa 437821 tcgctaaagc tgtcatcctt tctaatcacg gcaaacggca gtgaaatttg ggattcgaat 437881 tttaatttgg tggaacggaa gctgcttcat acggaccata ttcaaatgat gtgggatttg 437941 cggaataagc acaacactaa tttctgggct tctacggtga ataaagtatg gagaggcgag 438001 tttccggaaa acattacgga tcatgaatgg ctcaaattcg gctttgacat cgaggatgac 438061 gatatccgaa acgaagtgct tgaggagctg agaaaaaaca aagagctcga aatcacaaat 438121 tcaagtccga caaacattga agtcaacgcg cttggcatca acaaagctgc agcccttgcc 438181 aaggttacgg aaaaactcgg ctttacaatg gagaatgtga tggcgatggg cgacagcctt 438241 aatgacattg cgatgatcaa agaagcgggt cttggcgtcg caatgggcaa tgcgcaagac 438301 atcgtaaaag aaacggctga ttatatcacg gatacaaata ttgaggatgg tgtcgctaaa 438361 gcgattcgcc attgggtact ataaaaaaag agagtcctaa gatggactct cttttttagt 438421 ttggcaggtt ttattctggg accatggtag gttttctgac aaaagtattt cacaaactga 438481 tatgattcac ttataatgaa ataaagttca aaaattcgga atagtcgttc cgaatttcgg 438541 gacaataaat gacataaagc atatcgtttg ctttggcagg agggattctg tgtttcagat 438601 tgatttaaac tgtgatttag gagaaagctt cggagcctac aagataggcc ttgaccaaga 438661 tattttagag tatgtgacat cagcgaatat cgcatgcgga tttcatgcag gagatcctag 438721 tgttatgcga aaaaccgtcg cgcttgcagc agaaagaggc gtgaaaatgg gtgcgcatcc 438781 gggcttgccg gatttactcg gttttgggcg ccgcaatatg gcgatttctc ctgaggaagc 438841 gtatgatctt gtcgtttatc aaattggcgc gctctctggc tttctaaaag cagagggact 438901 tcacatgcag cacgtcaagc cgcatggcgc tttatacaat atggcggcag tcgatcaaaa 438961 actgtcggat gctatcgcga aagctgtcta taaggttgat cccggcctga ttcttttcgg 439021 tcttgctgag agcgagcttg taaaagcggg agaacggatc ggacttcaga ccgcaaatga 439081 agtgttcgcc gacagaacat accaatcgga cggcacgctg acaccgcgct cccagccgga 439141 cgcactcatt gaaagtgatg atgccgccgt cacccaggtc atcaaaatgg tgaaagaagg 439201 ggcggtcaaa tctcagcaag gacatgatgt gtcattaaaa gcagatacag tctgcattca 439261 tggagatgga gcccatgcgc tgacatttgc gcaaaaaatc agaaaacagc tcaaagcggc 439321 tggaattgaa gtgacagcta tttcagaaca gaggtcaaca taaaggagga acaatagatg 439381 gagcagcaga aaaagacagc aggaaaaaaa gcgggcagct ggtcattgct gatgggcgcc 439441 gcctttttaa tggcgacatc agcaatcgga ccgggtttcc tcacccaaac cgcaacattc 439501 acaaacacac tcgcagcaag cttcggtttt gtcatcttaa tctctattat tttagatatt 439561 ttcgcccaaa ccaatgtgtg gcgcatcatc gcagtttctg gaaaacgagg tcaggaaatt 439621 gcgaatatgg tgcttcccgg actggggtat ttcatcgcca ttctcgtcgt gcttggcgga 439681 ctagctttta atattgggaa tatcggaggg gccgggctgg gacttcaggt gctgttcggc 439741 attacacctg aaacaggcgc tttaatcagt gccgttatcg ccattttgat ttttgtcatc 439801 aaggaagcag gaaaagcgat ggaccgtttt acgcaaatcg cggggttcgt gatgattatt 439861 ttaacggtct acgttgcggc gacgacagct cctccggtcg gacaggcagt cgcaaataca 439921 ttcgtcccgg aacacatcag catatttgcc attgtcaccc tagtgggcgg aaccgtcggc 439981 ggttatatca catttgccgg aggacaccgt ttgcttgatg ccggaattaa aggaaaggaa 440041 tccattccgc aggtgacaaa gagctcggtt gtcggcattt taattacatc tgtcatgcgt 440101 atcgctcttt ttcttgcggt tctaggcgtt gtatcgaaag gcctgcacat cgatgaaagc 440161 aacccggcgg cttctgtctt caagctggct gctggaaatg tcggttataa aattttcgga 440221 ttgatcatgt ggtctgcggc gattacgtct gttattggag cagcctatac atctgtttca 440281 ttttttaaaa ccttttctcc aaaaattgaa aagaattcac gcggtattat tatcggattt 440341 attgtggttt ctacgttagc ttttgtcaca atcggccagc ctgcgaagat cctcgtcctt 440401 gtcggttcac tgaacggctt aattctgccg attgcgctcg gaacgctgct tgttgccgcc 440461 tacaagaaaa acattgtcgg tgattataag catccgcttt ggctgacaag cacaggcgcg 440521 cttgtagtga ttgtaatggc agttatggga atctacacgt tatgtacaca acttcctcaa 440581 ttgtggagct gatataagtg gagcaattaa acaaaatggc gccaaaggat gtacgcgccc 440641 tgatacgaga ggggaaaata aacgggccga ccgcaggcat gtccggcggc tacgcccaag 440701 cgaatcttgt ggttttgaaa aaggaccttg cgtttgattt tctgctgttt tgccagcgaa 440761 atcaaaagcc ctgccccgtg ctggatgtga ctgaagcagg ttcgcctgtg ccgtctctgg 440821 ctgcgccgga tgctgatatc agaacggact ttccgaaata ccgtatttac aggcacggta 440881 tcctaacgga agaagtatct gatattacgc catactggga ggacgatttt gtcggctttc 440941 tgatcggatg cagtttctcc tttgaacagg cactgatcaa taatgggata gctgtccggc 441001 atattgatga ggggacaaac gtctcaatgt ataaaacgaa tatcgattgt gttccggcgg 441061 gggcgtttca cggacagatg gttgtcagca tgaggccggt tcctgaacgg ctggctgtac 441121 gtgctgcaca agtgacctcg cgttttccgg ctgtgcacgg agggccgatc catattggca 441181 atccgggagc aatcgggatt cgcgatctcg ggaaaccgga tttcggagat gccgtttcca 441241 ttcgtgacgg cgaggttcct gttttttggg catgcggagt gaccccgcaa gccgtggcta 441301 tgaatgtaaa gcctgaaatg gtcatcacac atgcgccggg gcatatgctc atcacagata 441361 ttcgagacga gtcgcttgcg gtgctgtagc ctctcgtcat cctgatgaac gagaattaaa 441421 agaggtgaga aagatgactg tacgatatca aatcgaacag ctcggtgatt ctgcaatgat 441481 gatccgattc ggagaagaaa tcaatgaaca ggtcaacggc attgtccatg cagcggccgc 441541 ttatatagaa gaacagccat ttccgggatt cattgaatgt atcccggctt ttacaagtct 441601 aaccgtattt tatgatatgt atgaagtgta caagcatttg cctcaaggca taagctcacc 441661 ttttgagagt gtcaagcgcg atgtcgaaga gcggctggca gaaatagccg aagactatga 441721 ggtcaaccgc cgtattgtag aaattcccgt ttgctatggc ggtgaattcg gtccggattt 441781 agaagaggtg gcgaagatca atcaactgtc accggaggaa gtaatcgaca ttcatacaaa 441841 cggtgaatat gtggtgtata tgcttggctt cgcgcccggt tttccttttc taggcgggat 441901 gtcaaaacgc attgcagctc cgagaaaatc atcgccaaga ccgtcgattc ccgcaggttc 441961 ggtcggtatt gcgggattgc agacaggcgt ttatccgatt tcaacgccgg gcggctggca 442021 gctgatcggc aaaacgccgc tggctctttt ccggccgcag gaaaacccgc cgacattgct 442081 gcgggcggga gatattgtga aattcgttcg catctcagaa aaagactatc acgcctataa 442141 ggaggagtcc aattgagcat gaaagtatta aagcccggac tgctcacaac ggttcaggat 442201 ataggcagaa cgggttacca aaaatacggc gttctggcca gcggcgctat ggacacggtt 442261 tcactgcgca ttgccaatct gttgatagga aacggcgaaa atgaagcagg tctcgaaata 442321 acgatgatgg ggcccggtcc gtcgtttcat ttttcaaaac agacactgat tgctgtgaca 442381 ggggcggact tcacgctgcg tattaatgac gaggaagcgc ctttatggaa gcctgtgctc 442441 atcaaggaaa acagcacggt cagctttggc ccctgcaaac tcggcagccg tgcttatttg 442501 gcggcagctg gcggcattga ggtgcctgcc gtcatggaaa gtaaaagcac atacgtcaga 442561 ggaagcattg gcggacttca tggcagagcg cttcaaaaag aagatgaact gaacattgga 442621 gagatgtcag ctctttcgca aaccatcctt tctcgcttaa gttcgcagct tggaaaacag 442681 ggatttgcag caccgaagtg gtcagtcagc cgcggcagat ttctgccatt gaagaagaat 442741 cccgtcattc gggtgctgga aggaaagcaa tttgcctttt tcacagaaga atcaaaaacg 442801 cgtttttatg aagaagcatt tcgtgtcacg ccgcagtccg accgtatggg ctacaggctc 442861 aaaggagaac cgctcgaact gaaggccccg cttgagatgg tgtcggaagc ggtttcattc 442921 ggaacagttc aggtgccgcc tgacggcaac ccgattatcc tgcttgcaga ccggcagacg 442981 actggcggct atccgaggat cgcgcacatc atatccgctg atcttccgat tgtttcccaa 443041 atcatgccgg gcgagcacgt tcagtttgag cctgtgtccc tccaggaggc agaagcgctt 443101 gcggtagaac gggaacagca tataaaagaa ctgaaaacga gaatgaagat ggaatggctg 443161 acatagcaaa ggggatgaat gatgcagaat aaaaataaaa ccgtagtcaa atctatggcg 443221 ctgcttaatt tgtttttgca taaaccaagc ctaaccttaa gtgaactggt gtcgctgacg 443281 ggaatgccga agacctctgt tcaccggatg gtcagctcct tggaggaaat ggggttcctc 443341 agtcgggatg cgtccggcgc ttattcgctg ggattggtgt ttttggaatt cggacagctt 443401 gtcgctgaca ggctggatat cagaaaaata gcgaaaccgg tgatggaaga gctgtgccgg 443461 gaagtggatg aggccgtgca gttgatcatg agggacggca atgaagcgat atacgttgag 443521 aaaatagaag ggacacagac tgtgcggctg tatacggcga tcggcaggcg ttccccccta 443581 tacgcgggag cgtgcgccag aagcattctg tcctttcttc cccgtgaaga aatcgaagca 443641 tacatcaaac aaaccgagct catttcgatt ggctccggaa cgattaccga tcccgaaaaa 443701 ctgcttcagg agattgatgc ctctgtgcaa aatggctata ctgtcagcta ttcagagctc 443761 gaaaactata cggcggcgat cggcgccccg atctttaacc atgagcgcca ggtggcagcc 443821 ggcattagca ttgcaggctt tgaagcgaga tttacagaag acaggctgcc ctatttaaca 443881 gaaaaggtga aggacgccgc tttacagatt tcaagaaaaa taggatatac ataagtagcc 443941 aatcttttct ctgctgcgta cattaacgta tcgacgttca agagtggagg aaagaacatg 444001 gtgcttcgat atacagctct gggcgattcc ttgacgacag ggagaggctc cgggctgttt 444061 tcacccggct tcgtccagcg ttttggggac atgatggaag ctgacttgaa aacaagaacg 444121 gcaataaaca tatttgccag atcaggtctg aatacagaag agattttggg actcctgtca 444181 tatccctatg tgcaaaaatg tattcgagat gctgatatga taacgatcac agggtgcgga 444241 aacgatctca tcgattcggt cttagcctac caaacctcta aggatgaaac gattttcagc 444301 cgtgtatccg cccattgcca tgagaatttt gaaaagatga ttgccaaagt cgccgagatt 444361 aaaggagaaa atccttcccc gtacgccatt cgtgtgttca acttatacaa tccgtttccc 444421 gaaattgata tcgccggcaa atggatcact tcgtttaatt cacatttaga aacacttgca 444481 tcagcacccc atgtcaaaat cgcggatgcc tatagcatct tcaaaggcaa agaacaggaa 444541 tatctgtcct ttgacggtgt ccatccgaac agcaaaggct atcaagcgat ggctgaagcc 444601 gttcacaagc taggctataa agaattatca gtttcataga aaacgcgcct catgacaggc 444661 gcgtttttta tgtgtgatcg aaatattaaa agaaacttaa aattctctgt cttctgttct 444721 acagacaaac aaagtgcgct agaataatgg agggcgtagg caaatatagc cataacgttc 444781 aatatttcgt atataaggaa ggatggtcct tttgtttcgg atttttaaaa tgtcttttgc 444841 ggttatcatt attatactgg cgcttattgc ttttaactat acggaacaca cctctgtaat 444901 ccaatcggtc atgctcgtct ttcttggtgc ggtcatgttt atgcaggggc ttgaagagcg 444961 caaaaaagaa aatgacggct caggcgcttt taatatttat accgccgttt ttgtatggtc 445021 tgtctccctt atcggtttta cacttcatat tatataaatc tattacacat cctgaaaatg 445081 ctcgaccgtc gggaacgggg tatagaaccg atgaagcaag gctttccact cttgatactc 445141 tgaagaaccg cgaaagcctt ccgtatggtc ctcaagtgtt tcccactcca caagaagcag 445201 atatttatgc gtttcctcca tgcattttga taacgagtga gtgatatagc ccttcatgcc 445261 ggaaataatc ggcgcagctt gccggaatgc atcctcaaac tcttgttcaa ggccttcttt 445321 aatgtgaagc attgctgcct ctctgaccat gctatccctt ctttctgtct tttcaaatag 445381 tctacagcaa acgataggag atttctgcaa aatcggtgaa cttttccttc attttcaaaa 445441 aaatcttgca cgcaccaatt caattaagag aaaataacaa gtggaaggca ggggaaagtc 445501 atgttaaaaa agtgtattct actagtattt ctatgcgtcg gattgattgg gttaatcgga 445561 tgctccaaaa cagattcacc agaggatcgc atggaagcat tcgtgaaaca gtggaacgat 445621 cagcaattcg atgacatgta tcaaagcctg actaaagatg tcaaaaaaga aatctccaaa 445681 aaagatttcg tcaacaggta taaagccatc tatgagcagg ccggcgtaaa aaatttgaaa 445741 gtcactgcgg gagaagtaga taaggacgat caagacaaca agacgatgaa acatatcccg 445801 tataaagtca gcatgaacac aaatgccggc aaagtcagct tcaagaatac tgctgtgctg 445861 aaattagaaa aaacagatga cgaggagtca tggaatatag attgggaccc atcgtttatt 445921 ttcaagcagc tggctgacga caaaaccgtg caaattatga gcattgaacc gaaacgaggc 445981 caaatttacg ataaaaatgg aaaaggctta gccgtcaata cagatgttcc ggaaattgga 446041 attgttcccg gagagcttgg cgataaaaaa gagaaagtca taaaagaact cgccaaaaaa 446101 cttgatttga ctgaagacga catcaagaaa aagctggatc aaggctgggt aaaagacgat 446161 tcgtttgtgc cgctcaaaaa ggtcaagcct gaccaggaga aattagtttc tgaagcgacg 446221 tcattacaag gcgtaacaag aacgaatgtc agctcccgct actatccgta tggcgaaaag 446281 acagcccatt tgacaggcta tgtccgcgcc attacagcgg aagaactgaa gaaaaagaaa 446341 gaaggaacgt acagcgatac gtctaacatc ggtatcgccg gacttgaaaa tgtgtatgaa 446401 gacaagctaa gaggcacaac tggctggaaa atctacgtgc cgcaaaccgg ggaagtcatc 446461 gctgaaaaga aagcaaagga cggcgaggat cttcacctca caattgatat caaaacgcaa 446521 atgaagctgt atgatgaact gaaggatgac agcggggcgg cagtcgcgct gcagccgaag 446581 acaggcgaaa cactcgccct tgtcagcgcg ccttcctacg atccaaacgg atttattttc 446641 ggctggagcg ataaggaatg gaaaaagcta aacaaagata aaaacaatcc gttttcagcg 446701 aaattcaata agacatacgc gccaggttct accattaaac cgattgcggc tgctattgga 446761 atcaaaaacg gcacccttaa agccgatgag aagaaaacaa tcaaaggcaa ggagtggcaa 446821 aaagattcaa gctggggcgg ctattcagtg acacgtgtgt ctgagagact tcaacaagtc 446881 gatttggaaa acgcccttat tacgtcagac aatatttatt ttgcccagaa tgcgcttgat 446941 atgggagcgg acacctttac aaaaggcttg aagacattcg gtttttcaga ggacgttccg 447001 tacgaattcc cgatccagaa atcgtctatt gcaaatgaca agcttgattc agacattttg 447061 cttgcggata caggctacgg acaagggcaa atgcaaatgt ctccgcttca cttggcaact 447121 gcttacacgc catttgttga caatggagac cttgtcaaac cgacgctgat caaaaaagat 447181 tcacaaacag ctgatgtttg gcacaagcaa gtggtcacga aggaaggagc ggcagacatt 447241 acaaaaggtc tgaaaggcgt tgtggaagat gagcgcggat cagcgtatca gcctgtcgtg 447301 aaaggaatca cagtggctgg aaaaacagga acagccgagc tgaaaacatc aaaagatgat 447361 aaagacggca cggaaaatgg ctggtttgtc ggctacgatt acgaaaacaa agacctgctt 447421 gtcgccatga tgatccaaaa tgtgcaggac cgcggcggca gccactatgt cgttgagaaa 447481 gcgaaaaagc aatttcaatc gaattaaaat gtctttttaa aaggagcgaa aggaaaaagg 447541 ggatctgagg ccgaatgaac tagtaagggg gcaaaacccg gtttatacaa agaaaagagg 447601 gattttgcat gcagcgtatt caattggcgg aggatcttca attttcaaga gtcatacacg 447661 ggctttggcg gctgaatgaa tggaactatt cagatgctga acttctaagc ctcattgaat 447721 ggtgtatcga tcacggcatc acgacctttg atcatgcgga tatttatgga ggctatacgt 447781 gcgaaaagct gtttggaaac gcccttgccc tttcgcctgg attaagagaa aacatagagt 447841 tggtcacaaa atgcggtatc gttcttgaat cgcctgaacg gcccgctcac agatcgcatc 447901 attataacac aagcaaatcg catattttgg catccgttga gcaatcgctt atgaacctta 447961 ggacggatta tatcgatatg cttttgattc acagaccgga cccgctcatg gatccggagg 448021 gggtagcaga ggcgtttcag gccttgaaat gctctggcaa ggtcaggtac tttggcgttt 448081 caaattttaa agatcaccag tatcggatgc tggaatcata tttgcctgag aagctcgtaa 448141 ccaaccagat tgagctttcc gcatacgaat tagaaaatat gctcgacggc actttgaacc 448201 tgtgccagga aaaacggatt ccgccgatgg cttggtcgcc tctggcaggc ggcaaagtat 448261 tcactgaaaa cacggataaa gaccgacgtg tccgtacggc gcttgaatcc gtccaagggg 448321 aaatcggcgc cgcttcattg gacgaggtga tgtacgcatg gctgtatacg catccggccg 448381 gcatcatgcc gattgtcgga agcggaaagc gcgagcggat ttccgccgcg ataaatgcgt 448441 tgtcatacaa gcttgaccag gatcaatggt tccgcatttt tacagccgta cagggttacg 448501 atattccata aaaagcatca gtttaccagc tgatgctttt tcaatattgt cacaccgctt 448561 agtgccaaat taccatttat aagtgattga ttctttcttg aaagcgtttt atattaaaag 448621 gaaacctctc tatatcctct actgcatctc cttgcgactt catccgcaca tcaagattgg 448681 ctaggaggtc ttttttatgt atatgactgc cagagaacaa aagctgttaa agcacttatt 448741 attacaaaac agatatataa ccgtaactga gcttgctgag ctgatgcaag tcagcacgag 448801 aaccattcac agggaactca aatcaattaa accgctgatg gaaaccgtgg ggcttacgtt 448861 agataaacag cccggtaaag ggttgaaagc agtgggaagt cccgagggta aacaaaagct 448921 gcttactgat ttatcatatg aacagcatga atacagcgcc gacgaacgga aactgctcat 448981 tctttgttcg ttattagagt ctcaggagcc cgtcaaactg tacacgcttg ctcatgatct 449041 ccaggtgacg aatgccacgg tcagctatga cttagatgag ctcgagaagt ggatttctcc 449101 ctttggactg acactgatcc gcaaaagagg ttttggcatc cagctcatag ggccggagaa 449161 tgcgaaacgg aaaattgtcg gcaacttgat tgtgaaccgt ctcgacatcc aaatgttttt 449221 ggaagcggtt gaattaaaca tcaaaggaaa aaccgattct tcagagaaaa tgttcggggt 449281 tgtcagcaaa ggtgagctgt taaaaatgga gcgcatctta tttcagctca aagaaaaaat 449341 cgctttttca ttgtccgaca gctcctatat agcgctcgtc gtccatctga cgtatgcgat 449401 cgaacgaatt aagcttgggg aaactatcac catggagcaa aatgagcttg aggaactgat 449461 gaatgcgaag gaatacagct ccgctcttga aatcgcgggc gagcttgaac gtgccttcgg 449521 cgtgacgatt ccagaggcgg aggtcggcta tattacaatc catcttcgaa gcgccaatcg 449581 aaaatacaaa acagaataca aagcgcagga aattgagctg gaaacagccc tgcaaacaaa 449641 gcggctcatt gcttttattt cagacaaaat cagaatggat ctgacgaaaa actactcttt 449701 atatgaaggc ttgattgccc atttggagcc ggccgtcagc cgcataaaag aaaatattga 449761 gatatacaat ccgatgaagg aacagatcaa gcgcgattat tttctgcttt atatggcgat 449821 cgaagaaggt gtcgaaaagt attttccggg catgtccttt tctgatgatg aaatcgcttt 449881 tatcgttctt cactttggct cggctcttga aatcaaaaaa gaagaagcaa aagtgaaagc 449941 gcttgtcgtc tgctcaagcg ggatcggctc ctcgaaaatg cttgcctcca gactgaaaaa 450001 agagctgccg gaaattgaat cgtttgatat gtcatctctg atcgagctaa aggggaagga 450061 tgttcaagcc tatgatatga ttgtgtccac tgtaccgatt ccttatgaaa acattgatta 450121 catcatggtc agcccactat taaatgagga agacgcaaac caggtcaagc agtatatcaa 450181 gcggaagatt ccccttattc ttaacaaaaa aagaagctcg aaggaagagg cgcagcaagc 450241 tgatgtacct gacatgctgg aggcggcgga aagcataggg cggtatatgg aagttatcca 450301 agatgttctg cgccatttta cgctagctca actcaaaaca aacccggacc atagcatgct 450361 tctgctagag ctttttcaac agctgaagaa ggatggcctg atccgtgatc cggaaaaagc 450421 cgcggtttgc ctggctgagc gggagaaaca agggggattg ggaatccccg gaacaaacat 450481 ggcgctttat catctcaaaa atgatgaaat cgtcctgcct tttttcaaaa tgtttgatct 450541 cagcaccccc tatgaagtgg atggcatgga cggaaatacc ctcaggatga cacgcattct 450601 cgtcatgatg gcgcctggct cattatctgc tgaaggctcg gagattttaa gcgcgatcag 450661 ctcggcaatt atcgagagcg gagaaagcat ggcggggttt caggaagaag gaggacaaga 450721 attgtatcag cggttaaacc gcatattttt cacatggatg aaagaaaaaa acatactgta 450781 aacctgcatg gcacacgtca aaaatttggc gtgtgttttt ctgtggatgg ggaacaaaat 450841 aagaaaatgt gggactattt tatcattcag tattggaata attccaaaat gaaatagttt 450901 tacaagttat cttttttggg ttaaaatggg tgaggtaagg aagaaaatct aacaaattat 450961 tgaagattca agagaatata ggagatgacg atatggaaac attacagcat ctgattctgc 451021 atgacatgcc gaatagcgaa gaaatagagg ctgtaaaaag cggagaccat acactgacat 451081 ataaaggtta ccgtaaacgg attaatcagc tggcgaatgc catgcttcaa aaaggaattc 451141 aaaagggcga ccgtgttgca ttgctttgca aaaacggcca tcccgcctca actgttatgt 451201 tcgccgcact tgaaataggt gctgttgtcg tacctgtcag ctggcagctg aaaccatatg 451261 aaatgacagg cattttaaaa gcaagtgaac caaaagcgat gttttacgga gcggagttta 451321 aagagatact ggatgaagtt cttcctgaat tgtcctcact gtgtgtaaca atggaaacag 451381 gaacagctta cgaaacatct gctgaatttg aagcgctgtt tgcaggtcct gatcatttgc 451441 cagagacgga aatggtttca cctgatgata cagcacttct gatgtttaca tctggaacaa 451501 cgggaaaccc gaaaagatgc atgattacac atggcggcat atacagatac gttaaaaaat 451561 ccaacagctc aatagcacgt atgaagggcc ttcgttttct cgcgtgccat ccgatttatc 451621 atacgagtgc gctcatttgc atcatgcttg gaacgtttgc agaaacaaca tttgtgttta 451681 caaaggatca agatcctgtt cacatgctga aggtcattga agaagagaag attcagaccg 451741 tgatggctct tcctgtgttc tacacgtatt tgcttgaggc gtgggaaaag caccaaactg 451801 acttatcttc gcttgttatt ttaatgacag gcggaacaaa agtgccgagc agcctaataa 451861 gccgctatct tgatattggc attccgcttg cgcatggcta tggaagtact gaggcttggg 451921 gcatcagcac atggacgcct gatatgggaa tggataaagc ggcatctgca ggaaaacctg 451981 tggcaggtgt taaagtcaaa gtggaagatc ctctgaccgg agaagaactt cctcaaggag 452041 aaatcggcga aatcgttgtt catactccat tcttatttaa aggctatgaa gacaatcctg 452101 aagcaacagc gaaagtgctg caaaatggat ggtttagaac cggagattca ggatatgtag 452161 atgaagatgg ctttattttc atcacgggac gctacaagga tgtcattatt tacggaggcg 452221 ataacgtcta tcctgatcag gttgaagaag ttatccagca gatcccggga atccttgaaa 452281 cggctgtggt cggtattcct gacccgcttt acggtgaaaa accgaaagct tttatcgtga 452341 aaaatggcgg ccagcgcatc acggaagagg atgtcatcgc attttgtaaa gaacgcctgt 452401 ccgcttacaa aatacctgaa gttgaatttg ttaacgaact gccgaaaaac aaccttggca 452461 aggtgaaaaa agacgtcctg cgcaatcagg ctgtacattc ataaaagaag aagcccgtcc 452521 actttatgtg gcgggcttct ttgcagttgc acagacggaa agctcaggct taatgttctt 452581 aaattgtata tcaatgtctt cgaagccggc tgctttaaag tcagcaatca tctgtcttcc 452641 aaatgatttg gttttctcag gactggcatc cgcttcccgc ggctgcatcg taatggctgc 452701 tttgccgcct ggctttaatg cccgataaat ctgttttatg ccttttgttt ggtcattcca 452761 aatggtgtag ttgttaacgg aaatcacttt atcataaaac gaggcgggga gaggaaatgt 452821 ctcgatgctt ccttgtatca ggcgtacgcc ctttggtttc actctgcggg cggccagctt 452881 cagcatggcc tctgatacat caatcccatg aagatgaaca tccttctcgc gtttcagcat 452941 ctgctgcatg cagtatcccg ggccaaaccc gacttctaaa atgctgtccc cgcgcgtgat 453001 acccagctga ttgattgtcc actgattcag tgtttgattt tcagcagcca tgatgtaccc 453061 ggcaatcatg ccgatgacgc cctttggcct gctgaatctt ctagaaagca tgttaatcat 453121 tcagcaacca accccctttt tgagttaatt tcctctcagc gttccatgtg aaacattttt 453181 ctgataaagc aatgcgaagg tgccaagcca tgtttatcca aagagtgtgt gaggtacaca 453241 acaaatagac atgaaaacaa aggaggagaa tcatcatggc aaattatcca aaagaactgc 453301 cggcacaaac tcaaagtcgc cagccgggaa ttgaaagcga aatgaatcca agtccggtgt 453361 atgagtacga ggattataaa ggagcagaca aattaaaagg aaaagtagct cttattacag 453421 gcggcgacag cgggatcgga cgcgcggttt ccgtcgctta cgcaaaggaa ggcgcagaca 453481 tcgccattgt gtataaggat gagcatgaag acgctgagga gacgaagaaa cgtgttgaac 453541 aagaaggcgt aaaatgcctg ctgattgctg gtgacgtagg tgaagaggaa ttctgcaatg 453601 aagcggttga aaaaacggtc aaggaactag gcggccttga catccttgtc aacaatgcag 453661 gtgaacagca cccgaaggaa agcatcaaag atattacgag cgaacagctt caccgcacat 453721 tcaaaacaaa tttttattct caattttatt tgactaaaaa agcaattgat tacctgaaac 453781 cgggcagcgc catcatcaat acgacatcca tcaacccgta cgtagggaac ccgacactga 453841 ttgattatac agcgacaaaa ggggcgatca atgcctttac aagaacaatg gcgcaggcgc 453901 ttgtcaaaga cggcatccgt gtaaatgcag tcgcgccggg tccaatttgg acgccactaa 453961 tcccagctac gttccctgaa gaaacagttg ctcaatttgg gcaagatacg ccgatgggcc 454021 gtcctggaca gcctgttgag cacgtcggct gttatgtgct tctggcatca gatgagtcct 454081 cttacatgac aggtcagacc ctgcatgtca acggcggaaa ctttgtgacg acataagagg 454141 gagtgagaca tatgggcatc acgaaagaag aagtgaacag ctactatcaa aaagcaggga 454201 ttgtattaac ggacgaggaa gtagaccaaa tccagctgat ggattacggc ttaggaaaag 454261 aaagaaaagt cgggctccag ctcttcgtct acgtcaatac agaccgttat tgttcaaagg 454321 aattggtgct gtttccggga cagacttgcc cggaacaccg ccatccaccg gtcgacggcc 454381 aggaaggcaa gcaggagacc ttccgctgcc gctacggaaa agtgtatctt tacgtagaag 454441 gagaaaaaac gccgcttcca aaagttctcc ctcctcagga agacagagaa cactatacgg 454501 tctggcacga aattgagcta gaaccgggcg ggcaatacac gattccacca aacacaaagc 454561 attggttcca ggccggggaa gaaggtgccg tcgtgacgga aatgtcatcg acgagcacgg 454621 ataaacatga tatctttacc gatccaagaa tataaggatg ggcttaacag cccatccttt 454681 ttgtattgaa aaaaacagaa tcatcgctat aatgggtaaa aaaggaaaga gggcgaggca 454741 atgttcactt gcaaggtaaa tgagcacatc accatccgat tattggagcc gaaggatgcg 454801 gagcggctgg ccgaactcat tatccaaaat cagcagcggc ttggcaagtg gctgtttttt 454861 gcggaaaatc caagcagcgc tgacacgtac cgagaaacaa tcattccaga ttggcggcgc 454921 cagtatgccg acctgaacgg cattgaggcg ggtctccttt atgacggcag cctatgcggc 454981 atgatcagcc tgcataacct tgatcaagtg aatcgtaagg cggaaatcgg atattggatt 455041 gccaaagaat ttgaagggaa aggcattatt acagctgcct gccgaaaact cattacgtat 455101 gcttttgaag agcttgagct gaatcgtgtg gcgatctgtg cggctgtcgg aaacgaaaaa 455161 agcagagcgg ttccggagcg gatcgggttt ctagaggaag gaaaggcacg ggatggctta 455221 tacgtaaacg gcatgcatca cgacctcgtc tactacagtc tgttaaagcg tgaatgggaa 455281 ggcgaaaaat aaagagcaca ctttcttgtt taaatcttcc ccggatgtgg aaaagtaaca 455341 gcggagacgt taaaaaggag tgattcgaga tgaatcagca agacattaaa caaaaagtgc 455401 ttgatgttct agatcaccat aaagtaggtt cgctcgcaac agttcaaaag ggcaaaccgc 455461 attcccgcta catgactttt ttccatgacg ggctgacgat ttacacaccg acaagcaagg 455521 aaactcataa agcggaagaa attgagaaca accccaatgt ccacatttta ttaggctatg 455581 attgtgaagg ttttggcgac gcatatgtcg aagttgccgg aaaagcaaag atcaacaatt 455641 cggcagaact caaggacaaa atatggagtt ccaaattaga gcgctggttt gacggcaagg 455701 atgatccgaa tctggtgatt cttgaaattg aaccggagga tatcagatta atgaatgccg 455761 gggagaaaac accggtctca ctcgaactat aaaaaatttg tgttttcagg ggcgatatgt 455821 tattatgaat agctagtaag aaaaataagc aaataaaaaa gaaagtaaac ttcttttttc 455881 tgttttgaga gagaagctta ccgcttccca agcagcataa ccagctgccc ttattctttt 455941 ccttcataac aaatcgcccc taacgatgag atggaaaaaa gacttttttg ttttacaatt 456001 cacaccggcg cggcttcgga gccgcagtga cgattgagag gtagggcttt cgttgtcttg 456061 tgttcaagaa atttccatgg tgtttacttt ccagaatgat tcttcggaac aatgctttat 456121 gaatctaacc cgcctgactt ggcggatgat ataatcttta tttgcgtata gaaaagaata 456181 agacaaaccg cccggcgtac gccggacggt ttttttattg caaaaaacac atcgtactga 456241 aacctccttg tcttctttcc agtcttatct ctaggatgaa attggaggaa gaataacgtg 456301 catgtcatta caacacaagt actttttatt ttttgttttt tattgctgat tcactcgata 456361 gaaaccttag cctatgcgac aaggctttcc ggagctcgcg ttggatttat tgcgtccgcg 456421 ctttctctgt ttaatgtcat ggtcatcgta tccagaatgt cgaatatggt gcagcagccc 456481 tttactgggc atttaattga tgatgctgga aaaaacgcac tggcgattgt aggggagcag 456541 ttccgctttt taattttcgg atcgacagtc ggcaccattt tgggcattat cctgctcccg 456601 tcttttgtcg ctcttttttc acgggcgatt attcacttgg cgggcggcgg cggctccgtt 456661 tttcaagtat tccgaaaggg attctcgaaa caaggattca aaaatgccct ttcctatttg 456721 cgtctgccgt ccatttcata tgtaaaagga tttcatatgc gcttgattcc gaagcgtttg 456781 tttgtcatca acatgctgat cacatcgatt tatacgattg gtgtgctttc ggctttatac 456841 gcaggccttt tggcgccgga gcgcagcacg acagccgtca tggcttcggg tttgatcaac 456901 ggaattgcaa cgatgctgct ggctattttt gttgatccta aggtatccgt tcttgctgat 456961 gatgtggcaa aaggaaaacg aagctatatc tatttaaaat ggacctctgt cacaatggtc 457021 acatcaaggg tggcgggcac actcctcgcc cagctcatgt ttattcccgg ggcctactat 457081 atcgcgtggc tgacaaagtg gttttaataa gaaaggctgg atcataaaga tccagccttt 457141 ttgcgcttcc ttatttatag ttccttaatc cgcggtcgta caaaaaattt ccgaatggga 457201 cgaaagcggc gatgaagccg gcagctgacc atttcagcgg ccatttgaca gagaaggttg 457261 cataagccaa gacaagcaaa tacaaaatga acaacccgcc gtgaaccgaa ccgacaattg 457321 tcaccgcaag cggaaggcct gcccaatatt taagcggcat agcgatgaac aacaggatta 457381 agagtgacat tccttcaata aaacccatcg tgcgaagtct tccgatcggc gtgtgcagca 457441 taaatcgccc tccttgtgga cacgttttca ttttatacta taaacaatcc gggggggcat 457501 atgacagctt tcaaaaaatg ttcggaaaac attcattttt acatgccttt tctagggaac 457561 tgtacttgtc atttacaaaa atacccgaga taatgtgtac aaaatcaaaa aagaaggatg 457621 ttgaaatgaa acttgaccag attgatctga atatcattga ggagctgaag aaggacagcc 457681 gtttgtcgat gagggaatta ggcagaaaaa ttaagctgtc gcctccatct gtaacagaac 457741 gggtaagaca gcttgaatcg tttggcatca tcaagcaata cacgctggag gtcgaccaga 457801 aaaaactggg gcttcccgtt tcctgcattg tggaagcaac cgttaaaaac gcggattatg 457861 agcggttcaa aagctatatt caaacattgc cgaatattga attttgctac cggattgcgg 457921 gtgcagcctg ctatatgctg aaaatcaatg ccgaaagcct cgaagcggta gaagatttca 457981 ttaacaaaac atcgccctac gcgcaaaccg tcactcacgt cattttctca gaaattgaca 458041 cgaaaaacgg gcgcggttag agagtgccgc gcgaagtctg ttataataac aggatgagcg 458101 tgaaagaaag agaagtgatc aagcatgtca aaaacagttg tattagctga aaaaccttca 458161 gtcggccggg atttagcccg ggtactgaag tgccataaaa aaggaaacgg ttatctcgaa 458221 ggcgatcaat atattgtgac ttgggcttta ggccatttgg tgacgcttgc tgatccggaa 458281 ggctacggaa aagaatttca atcatggcgc ctagaggatc tgccgattat cccagaaccc 458341 ttgaagcttg tggtgataaa aaaaaccgga aagcagttca atgcagtcaa atcccagctt 458401 acccgtaaag acgtcaatca gattgtcatc gcgactgacg caggccggga aggtgagctt 458461 gttgcgcgct ggatcattga gaaagcgaat gtccgaaaac caatcaagcg gctgtggatt 458521 tcatctgtga cggataaagc gatcaaggaa ggttttcaaa agctgcgcag cggcaaagaa 458581 tatgaaaacc tgtaccattc tgccgtcgcc agagcggaag cggattggat tgtggggatc 458641 aacgccaccc gtgcacttac cacaaaattc aatgcccagc tctcatgcgg gcgtgtgcag 458701 actccgacgc ttgccatgat tgcaaagcgc gaggcagaca ttcaggcgtt tacgcccgtt 458761 ccgtattacg gcatacgtgc tgcagtcgac ggcatgacgc tgacgtggca ggataagaaa 458821 tcaaagcaga cgagaacgtt caatcaagat gtaacaagcc gtttgctaaa aaatctccaa 458881 ggaaagcaag cggtcgtagc tgagctgaaa aaaacagcga aaaaaagctt tgcgcctgcg 458941 ctttatgatt taacggagct ccagcgtgac gcccacaagc gcttcggttt ttctgccaaa 459001 gaaacgcttt ctgtcctgca gaagctatat gagcagcata agctcgtcac atatccgcgg 459061 acggactcta gatttttatc cagtgacatc gtcccgacgt taaaagaccg tctggaaggc 459121 atggaagtaa aaccgtatgc ccaatatgtc agccaaatta aaaaacgcgg cattaaatct 459181 cataaaggat atgtcaatga cgcgaaggtg tcagaccacc acgcgattat cccgaccgaa 459241 gagccgctcg ttctcagcag tctgagtgat aaagaacgaa agctgtatga cctgattgcg 459301 aaacgtttcc tggctgtatt aatgcctgca ttcgaatatg aggaaacaaa ggtcatcgca 459361 gaaatcggcg gagaaacctt tacggcgaaa ggcaaaaccg tgcagtcgca agggtggaaa 459421 gccgtttatg atatggcgga agaggatgat gagcaggagg atgacagaga tcagacactt 459481 cctgcgcttc aaaaaggcga cacacttgcc gtccgcacgt taacggaaac aagcggccaa 459541 acgaagccgc ctgcccgctt taatgaaggg accttgctgt cagcgatgga aaacccaagc 459601 gcgtttatgc agggagaaga aaaaggcctc gtcaaaacgc ttggagaaac aggcggcctc 459661 ggcacggtgg caacgcgtgc cgacattatt gaaaaactgt tcaacagctt tttaatcgag 459721 aaaaaaggcc aagatatttt tatcacatct aaaggaaaac agctcctgca gcttgttccg 459781 gaggatctga aatcaccggc cttaacagca gaatgggagc aaaagctgtc tgcgatcgcg 459841 gccggcaaat tgaaatcggc tgtttttatt aaagatatga aggcttacgc tcaccaaacg 459901 gtaaaagaaa tcaaaaacag cagccaaacc ttccgacatg acaacattac gggaacggca 459961 tgtccggaat gcggcaaaat gatgctgaaa gtaaacggca aacgcgggac gatgctcgtg 460021 tgccaagatc gtgaatgcgg aagcagaaaa acgattgccc gaaaaacaaa cgcacgctgc 460081 ccaaattgcc ataaaagaat ggagcttcgc ggccaaggcg agggccaaac ctttgcgtgt 460141 gtgtgcggtc accgtgaaaa gctctctgta tttgaaaaac gaaaaaacaa agacaaagcg 460201 cgtgctacca aacgggacgt atcctcttat atgaaaaaac aaaataaaga tgagccgatt 460261 aacaacgcgc tggcagaaca gctgaaaaaa ctcggtttgg ataaataata aaaaaacctg 460321 tgcctatcgc acaggttttt tattggactt aggtcctgtt ttcttaatgt tcaaaaaggg 460381 aaaaaaaagc tagcaatctg catttttttt cttttatagt aaatgtactt tgtaacatgg 460441 cagtcatatt ttcgtctata actatttgtg agcgtctgat ttgcttcagg cgacaaaggg 460501 ggatttgcct gtgaggcatg tactaattgc tgtcatctta ttcttcttat ctatcggact 460561 ttccgcaggg tgtgctgaag ctggaaacaa gacccaaaat cagtcggcga cagaagtgaa 460621 tgccagcccg ctccagccgg cggaatattt catctatcac aatttaatga atgacaaagg 460681 gctgatcaaa accgattttt cagaccagcc ttcttacttg tcggaatctc tcggactgtg 460741 gatggagttt ctgctcagca aaaatgacgc accacatttc caggatcaat atcagcatct 460801 gactgattca tttctgatga gcaatcactt ggtgacgtgg aagattcaaa atggccaagc 460861 gagcgggacg aatgcgctga tagatgatat gagaattatg ctgtctcttg accaagccgc 460921 cgcaaaatgg ggccgcagcg actacgcgca aacggctagg gatatcggca cgtctttgaa 460981 gacatacaat atgaacaacg ggttttttac agacttttac gactcacagg ccgcttcaaa 461041 ggatgtgacg ctttcatacg tcatgcctga tgccttagct gtcttaaaga agaatggaat 461101 catagacgaa gaaacagaac agcggaatgc caatgttctc tattcagctc ctttaaaaaa 461161 tggctttctg ccgaagacat acagctcgga gacgaaggaa tacacatatg atagtgaaat 461221 caacctgatt gatcagcttt acgctgcttg gcatttgccg gaaggggatg aaaaagcatc 461281 tgttttagcg gactggatca agcaggaatt tcagaaaaac ggaaagctgt acgggcggta 461341 ttcggcatat acgaaggagc ctgccgtcca atatgagtct ccatccgtat atgccttagc 461401 cgtattgttt ttgacaaaac agcatgaaaa cagttctgtc atcaaagcca tatatgatag 461461 aatgaatgac tttgaaattc atgatccggt gaaatcgtat tatggaggct atatgagcgg 461521 cactcagacg cattcatttg acaatctgct gccgctgtta gccgaaagga agctttttaa 461581 tgaaaatatc attcagtgaa tcacaaaaat tatttgctta tttttcaggg ctcatcgcgg 461641 ccctgtcttt gtttatttat tatgtgtcag cccagcaatc agaaggtgct ctgatccttt 461701 gcatcacatt tggcgtcatc gccgcaggca tctggttcgg cccgatttac gcgctggcag 461761 tgaccttaat cgtactcttt gttctcggca ccttaatgat gtttttccag actggacaga 461821 catcgctctt tccggctgag gaagggctgc gaatgcttgt cgtgtgggga atcgcgcttt 461881 tgctgttttc ttttatttct ggaagaatcc acgatattac agcagagctt cggcgctcaa 461941 tgacacggct tcaatccgaa attaaaagct atgttgctgt tgacagagtg actggttttg 462001 ataacaagca aaggatgaag ctggaacttt cagaagaaat caagcgggcg gagcgctacg 462061 gcaattcttt tgtgtttttg ctgctccata tgcattattt caaagagttt aagtctttgt 462121 acggtgaaaa agaaacggac cgcctcttcc aatatgtcgg tcagcaaatc aggacaagcg 462181 ttcgggaaac ggataagaaa ttccgtccct ctgacgagcg tatcgggatc gtgctgacgc 462241 acacgcctgc tgaacatatg ccggccgttc tgactaagct gaagaaacaa ttggatacat 462301 atcagctgga aaatggaaag tatgtgtcgc ttacgttcca cgtttgctat ttgccctacc 462361 gcaacgatat ccaaacagct gatcaatttt tagaagaact ggaaaacgag atgatgatga 462421 atgaactata aaggaatcac attgctatgc gtcatgatgc ttctattttc agctattgcg 462481 tcttttcccg tttctgcgca agcgaaagat caggatgccg gcattctcat catctactca 462541 accttggacg gcaaagagtc gtcacaagtc aaaatgctcg atttgcttgc gggccacttt 462601 acatcccatg tgacagtcaa aaaagattca gacgttgaag cgtcggattt caaagggaaa 462661 gaccatgtga tttattacgg ccaaacgaaa agaaagctca gccaaaaatt gctgtctctt 462721 atcagcggcg tgaaaaaacc ggttgtcgcc attggctata acgcaggcca aatcagccaa 462781 ttttctgggc tttcattagc ccgcaaagaa aatgtgtttc aggttcacag caggtcagaa 462841 aaggccgatg tgtctctgga aagcgggctt aacgtgctga gtgtatcagg cctgaaagga 462901 acggcgcttt acaccttcaa agcggatgaa ggcacaacgc attcttttat atggaaaaca 462961 aaaaaaggga atgtgtacat tggattaaca aatttgttaa atgacaattt gatcgtggcg 463021 aaacagctca gagaagcttt cggagagaag gcggggacga cgttattgta tttgcgtctc 463081 gaggatatca gcccgatgtc tgatgaaaaa ctgctgcttc aagccggtac atacctgcat 463141 aagcggcata ttccttttat cctggcggtc attccggttt acttgaatcc ggaaacaggc 463201 gacaaagtgt atttgtctaa tcaaccgaag atggtcaagg tgctgaagaa gctgcaaagc 463261 atgggcggca gtatcatagt tcacggctat actcacgctt atcgctacag tgaaacagga 463321 gagggatttg aattttggga tgcaaaggcg gatcagccga ttacatccgg aaatgccgaa 463381 gaccccccgt ccattttgga gaaagaacag gacttcccga acgaacaagc ctatcacagc 463441 tatcttgaac catttcggga aaaggaagaa acgtatacaa aacaaaaact gacgcgtgcc 463501 attgaggatt tgacatcatc gggtctttac ccgctggcgt ttgaagcgcc gcattacacg 463561 atgtccgaat atggctatca aatcgcctcg cagtatttta caagcatttt cggccaggtc 463621 cagctcagca gcacaacatg gaaaacatcc ggtgcacctc cgtttgtgac tgctccttcg 463681 atgctgcacg gaatgacgct ttatccggaa acgatcggct ttgtcgacac atcgaagcaa 463741 aacccgctcg gtgagatgga ggagcatatc tcccagatga ttgattttga aggcggagta 463801 gccggaggat tttatcaccc gtaccttggg atgaaatatc tgcctgagct ggttgatcag 463861 atggaacgca ttccagacag tgaatggctt gatttaaaga aaacgaaaca aaccgtcaaa 463921 acagacaaag tggaaattca tacaagcggt gacggaacga ttcaggtgaa aaacggcgta 463981 agccccattt acgagttttt cgatcatcac cggcaaaccc ctctggaaaa ggcgttatgg 464041 attctctccg ctgttgtgct cttatttgtc atcatgtttg tcagttatac gttttacttg 464101 agagccacat tgaaaaaacg aatttttaag gagagaagaa gccttgggta atacgctgtt 464161 ctttatctcg ctaagtttaa tatgggttat gcttctctac cacatgttcc tcatgcaggg 464221 cgggtttcgc cactatatga ccttcgaacg gaatatcccg aagtggagag aaaatatgaa 464281 ggaactgccg aaggtcagcg tcctcatccc ggcgcataac gaagaggttg tgattcggca 464341 gacgctgaag gccatggtca acctttatta tccgaaggac cggctggaga ttatcgtcgt 464401 taatgataat tcatcagacc ggacgggtga tatcgtcaat gaattttccg agaaatacga 464461 tttcatcaaa atggtgatta cgaagccgcc aaatgcagga aaaggaaaat cctctgcact 464521 taactcgggt tttgccgaat cgaacggcga tgtgatctgt gtgtatgacg ccgacaacac 464581 gcctgagaaa atggccgtgt attacctcgt gctcggcctg atgaatgacg aaaaggcagg 464641 cgccgtggta gggaaattcc gcgtcatcaa tgcggcaaag acgctgctga cgaggtttat 464701 taatatcgaa acgatctgtt ttcagtggat ggcccaggga ggcagatgga agtggttcaa 464761 aatcgccacg atcccaggca ccaacttcgc gatccgcaga agcattatcg aaaagctcgg 464821 aggctgggat gacaaagcgc tcgctgagga tactgagctg accatccggg tatataatct 464881 cggctatcac atccgctttt tccctgccgc catcacgtgg gagcaggaac cggaaacatg 464941 gaaggtatgg tggcgccagc gcacccgatg ggcgcgcggc aatcaatatg tcgtgctcaa 465001 atttttggcg cagtttttta agctgaaacg aaaacggatt atctttgatt tgttttattt 465061 tttctttacg tacttcctgt ttttctttgg cgtgatcatg tcaaatgcga tttttgtagt 465121 gaatttgttt tatgatttgc atttgtctgt tggatttttg gcaatgattc tctggatttt 465181 ggcgtttttc ttatttatga cagaggtcat gattacgttg agcattgaaa aaacagaaat 465241 gaacaagcaa aactttttta tcgtatttct catgtacttc acatactcgc aggcatggat 465301 tgtgcttgtt atctactctt tattcgtaga aatcaagcac cgtttattca agcaagaggt 465361 caaatggtac aagacagaac gatacaatca acataaaagc gggtgacctt tttgaaacaa 465421 ataatgattt ttctcacaag cttcatgctg ctggcgatga ctggacaaac ggctcttgcc 465481 aaagacgtac aggtcagcgg ttcgctcctt gggaaaagca gccaagaaca agccaaacag 465541 caggtgctga caagcgagct gattacactg tatggatcaa aagacagcgc agagctgacg 465601 tatcagatcc cggcaggcgc ctcttcgggc aatcagcaat tggtaatcga atacgaggca 465661 tcaaatcttt taatttctcc atcatcgtta acggttgtca ttgatgatga accggtcaag 465721 acgttaaagc ttgatggtga ttccaaacgg aaaacagtga agctgaatct gaataaaagc 465781 cagtctgcgc aaggctatca caacgtatcg ctgaaattct acggcgtaat gaaagagggc 465841 gtgtgcgtca gacaggatac atcaggcaac tggatcaaaa tttatccgga cagccggctg 465901 acacttgctg acagcagtga agcgaaggga acgtcgctgg accattatcc gtatcctttc 465961 gcccaatctg gaaatacagc ggaagaaaca gctatcgtca ttccggataa cccaagttca 466021 gcagaaatag aagctgctgt taaaacagaa ggctatttga aaacggtgga cagcagtgtc 466081 agtattgcgt atgtcacgga atctgaactg aaaaaaatcg ataagccgac gattgttatc 466141 ggcgtggaca agcattggaa cggcaaagtg aaaaaactgt tgaaacaagc cgggctacag 466201 gcaaaaggag aaaaccttct gcttgcggag cgggtgctga aagcagaggg caaacagcag 466261 ccggttctgt ttgcgcaagc ggcgtccgag gacgcgctca caaaaaaaat cagcgtgatg 466321 acagatcaga catatacagg ccagctcagc ggcgatacac tttcaatcag caagcttcag 466381 cagactgaaa aaaaagaaag cgataagctg acccttgaga attttggagc gggtgatatc 466441 acaattggag ccgacaaaac atcttcagca cattattttt atccggcttc ggctgtttta 466501 gatgaaaacc aatcggcgaa gctgtcgctt aaactgaaaa agtctgaaac gattcaagcc 466561 tcaacggctg aaaacgagtc agcctctcag gctgcagaac tgaaagtgat gatcaacggc 466621 cagccgcact cggtccggct tgatgaatta ggaaaagaag ataaaaacgg attctatcat 466681 gtcacagtga aagtggaccc taagctgctg caaaaaaacc gctacattga tattcagttc 466741 gtcacgaccg gtttaaagga aaacaaccct tgtaacacca ctgatgaaga aaagtgggtt 466801 tttatcgata aaaacagtac attatcatac gccatcaaag gcatgtcccc gtcagcggat 466861 tttcaagagt ggccgctgcc ttacgccgga aaccaggatc aaacaacgtt aatcgtgctt 466921 cctgacaccg taagccaatc gaagctagag gagctttctc tcgtaacaga atcctttggc 466981 aacgaagcac agcattcata tacggtaaag aaatcatctg acgttacagc aaatgatgcg 467041 aaaggacgaa acctcatttt cataggaggg atcaatcaat tttctcttct gaaggagaaa 467101 tcatcagatc tgcttgtgcc gcaggaaaag aacggctcgt ttgatgtatc tagtttcgag 467161 atgctgaatg agacgacaaa acaagtggta tttacccaag catcggtttg ggattcacgc 467221 tatacaatgg ctgtctttgc accgtcaaaa ggagatggca cggctgtcac aaaagagatc 467281 atcagttatc tgaacagcaa cgatgagtcg gcaaccgtcc ttaatgaaac aaacagccag 467341 caggtgttta caaaccacca gcagctcaaa tcggaaacaa acagttccga tgcagaacaa 467401 ccaacacagg atcatagcca gaaatggatg tatattggtg tgctggcact cattatggtg 467461 gttgcggcag tgttcatttg gattgccgta agacgcaaaa aaagaaagac agatacagaa 467521 taaaacagag gcgattttag cctctgtttt tttatttttg gtaagtaaat tccatttgtg 467581 gaacctgtca ttttattttt ttctctcagc caataagcct ctttacaacg tgcgggaacg 467641 ggagtatgat ctcttttaga aaacaaatcg cttaatctga aatcagagcg ggggacccaa 467701 tagaacggct ttttgccgtt ggggtgaatc ctttttaggt agggctaact ctcatatgcc 467761 cgaatccgtc agctaacctc gtaagcgttc gtgagaggag atgaatgaaa cctgtgttcg 467821 atgttatggc acaggggcat ccgtttgcct ctgtgttttt tgttgttcat ttttgaatgc 467881 aaatcgcata cagagacatc atagcagaaa ggactatcat caacatgtga gagcaagaca 467941 ctgatggatg ttttattgtt ttaattgaaa aatgagaaat taaaagggga agacatcgat 468001 gtatcattca atcaaacgtt ttttgattgg gaaaccacta aaatcccaag cagctggaga 468061 gcaaaaactg acgaaattaa aagccttggc tatgctttcc tcagatgcgc tgtcatctgt 468121 cgcatatggg acagaacaaa ttctaatcat tttggcaaca atcagtgcag ccgcattttg 468181 gtactccatt ccgattgcgg ttggcgttct catcttgctg ctcgcactga ttctttcata 468241 caggcaaatt atttacgctt atccgcaggg cggcggggcg tatatcgttt ctaaagaaaa 468301 tctcggtgaa aaaccgggat tgattgcggg cggttcattg cttgttgatt atattttaac 468361 agtagcggta agtatttccg caggcacgga tgccatcacg tcagcctttc ctgcattgca 468421 tgattatcat gtgccgatcg ctatttttct cgtgttagtg attatgattt tgaacctgcg 468481 cgggctttcg gaatcagcat ccatacttgc ctacccggtt tatctgtttg tggtggcgct 468541 tttggttctc attgcagtcg ggttgtttaa acttatgaca ggacaaatag accagccagc 468601 ccatcataca tcgctcggca cacctgtagc cggcattacg ctatttttgc tgcttaaggc 468661 tttttcctcc ggatgctcag cgttgaccgg ggttgaggcc atttctaatg cgattcctgc 468721 attcaaaaac ccgcctgcgc gaaacgcggc aagaacgctt gcgatgatgg ggattttgct 468781 ggcgattctg ttttccggca tcacggttct cgcgtacggg tatggtacgg cgccgaaacc 468841 tgatgaaaca gtggtttcac aaattgcgtc cgaaaccttt gggcggaatg tgttctacta 468901 tgtcatccaa ggtgtcacat cgcttatttt ggttcttgcg gcaaatacgg gattctcagc 468961 cttcccgcag cttgccttca acctggcgag agaccagtat atgccgcgaa tgtttacagt 469021 caggggcgac cgcttaggct tctcaaatgg gattatcttt ttaggctttg cctccattgt 469081 tctcattatc ttattcgggg gacagacgga gcacttaatc ccgttatatg ctgtgggcgt 469141 atttattcca tttacgcttt cacaaaccgg catgtgcatg aaatggatca agcaaaaacc 469201 aaaaggctgg atcggaaaaa tgctgatcaa ctcctgcggc gctctgatat catttatggt 469261 tctatccatt ctgtttgtga cgaagtttaa tgtcgtatgg cctgtgttaa tctttatgcc 469321 tatcgtcgtt ttgctgtttt ttgcgattaa aaatcactat actgcggttg gtgaacagct 469381 tcgcatcgta gacaaagagc cggaagaaat caaaggcacc gttgtgattg tgcctgtggc 469441 cggtgtcacc accgtcgtgc aaaaatcgat tcactatgcg aaatcactgt ccgatcaggt 469501 gatcgccgtt cacgtgtcat ttgacagaga acaggaaaag aaattcgaaa aacgttggga 469561 agagcttaat aacggagtgc gtctcgtgac gcttcactcc tcttacagaa gccttgtcca 469621 tccgtttgat aagtttttgg aaacagttga ggcaaaagcg aagaaggagc agttttccgt 469681 tatggtgctg tttccgcaat ttataacgaa aaaacgctgg cacaccatcc ttcacaacca 469741 atcggccttc ctcctcagag tccggctgtt ctggaaaaag gacataatgg ttgccacact 469801 gccgtatcat tttaaaaagt aaagctctag gaccaaggga atcaccttgg tcctttttag 469861 cgggaaaagg aggtatgggg gtgtatacac aaggtgcttt tgtgatcgta ttgaacgaaa 469921 gtcagcaaat tctgctggtg aaacgaaaag atgtccctct atgggatttg ccgggcggca 469981 gggttgatcc cggggaatcg gctgaggaag cggcagtgcg ggagatattg gaagaaacgg 470041 gatacaatgc agcgctttct gcgaaaatag gtgtttacca aaggccaaag tttcaagatg 470101 aacagcatct gtttttcgga agcattacag gcggacaagc aatggctgac ggcacagaga 470161 cagcgggatt aaagtgggtt tccccggggc gtttgccgct ttttatggtg ccgaatcgaa 470221 aaaggcagat caatgatttc aagaacggcg ctcaagatgt aaatgtcacc gtcaaggata 470281 gcgggttgct cgcggcgatc gacctgttga aaagaagact gggcaagtga ttcaggtctc 470341 cgggttttaa agcctttctc ctgtggtatt gaaaaaagga aaaaggagga tacgttatgg 470401 cacacaaaac tgcaggacaa gcaatgacag agctgcttga gcaatgggga gttgatcatg 470461 tatacggcat ccccggagac agtataaatg agtttatcga agaattaaga cacgaaagaa 470521 atcaactgaa gttcattcaa acccgccacg aagaggtagc ggcactggca gccgcggctg 470581 aagcaaaact caccggcaag atcggagtct gtctgtcaat cgcagggccg ggagcggtgc 470641 acttattaaa tggtttatat gatgctaaag ccgacggcgc ccctgtgctg gcgattgcag 470701 gacaggtttc ttctggcgaa gtcggacggg actatttcca ggagattaag ctggagcaaa 470761 tgtttgagga cgtggccgtg ttcaacagag aggtacatag cgcggaatca cttccggatc 470821 tcttaaatca ggcgatcagg accgcctaca gcaaaaaagg cgttgcggta ttgagcgtgt 470881 cagatgattt gtttgcggag aaaatcaaac gggagcccgt gtatacttca ccggtgtata 470941 ttgaagggaa cctagaaccg aaaaaagaac agctcgtcac ctgcgcccaa tatattaata 471001 acgctaagaa accgattatc ctggcagggc agggaatgaa aaaggcgaaa cgggagctct 471061 tagaatttgc ggacaaagcc gccgctccga tcgttgttac actcccggca aagggtgttg 471121 ttcccgataa gcacccacat tttctcggca acctcggtca gatcggaaca aagccggctt 471181 acgaggcaat ggaggaatgt gatttattaa tcatgctcgg aacgtcattc ccgtaccgtg 471241 attatttgcc tgatgacacg ccggcgatac agctcgattc agacccggca aaaatcggaa 471301 aacggtatcc ggtgacagcg ggccttgtct gtgattcggc tctcggtttg cgcgaattga 471361 cagagtatat tgaacgcaag gaagacagaa gattcctgaa tgcctgcaca gaacatatgc 471421 agcattggtg gaacgaaatt gaaaaagatg agacagaggc aacaacaccg cttaaacctc 471481 agcaggtcgt ggcccgtctt caggaagcgg cagccgatga tgcggtgctc tctgtagatg 471541 tcggcactgt gacagtctgg atggcgcgtc atttcaaaat gaacgcgaat caggatttca 471601 tcgtttccag ctggcttgcg acaatgggct gcggcctgcc gggagcgatt gcagcgagct 471661 tgtccgaacc ggaacgccag gcgatcgccg tctgcggtga cgggggattt tccatggtca 471721 tgcaggacct tccgaccgcc gttaaatata agctcccgat cacagtcgtt attttaaaca 471781 acgaaaatct cggcatgatt gagtacgagc agcaggtcaa aggcaatatc gactatgtca 471841 caaaacttca aaatgtcgac tatgccgcat ttgcagaaag ctgcggagca aagggcatca 471901 aagtgaccaa agcggaagag cttgcgccgg cttttcatga ggcgctgcac tctgaccaac 471961 cggtcgtagt ggatgtcatg attggaaacg aaccgccgct tcctggcaaa atcacctacg 472021 ggcaggcgaa aggctttagc aagtacatgc tgaaaaactt cttcgaaaac caaaaatttg 472081 aaatgccgtc actgaagaaa agtttgaaac ggttatttta aaaaaacagg ggccctaaga 472141 gcccttgttt tttttttttt ttttggaaac aaatgtattt tcagcatgtt tgaattcata 472201 aaatgatcgg tatatgtatt aggaactgat ttcgccatac tcgaaacaga caaaaggaca 472261 aatgcatctt gtttcaaagg aagatgcatt tgtccttgca tgcttattct tatcaaatct 472321 tacagaactc ttctcataat aggttatttt tcttttttct tcagcccgaa gaagaaagga 472381 aaagcagaac cgaccaagaa ggtgccgaat aaaaacatgc cgccgataaa cacgtggaaa 472441 tttgtgtgtc cggccgtaaa cgccgtgatt agggaaatga tactgagcac gatcatggca 472501 atgccgggcg cgactctcat ttttcccttg gatttatggg cagcaacaga acataaaatg 472561 ccgataacaa taggaacaat ccacaaataa aacagaataa atactgacat catcaaaact 472621 ccgatttttc ttctatcata acaaatttct gtcaaaaagg gtatcaatga gcttttgcgg 472681 aaaaataaaa accggcttta gaagccggtt tttttatcga aacgtatcta caattaaaaa 472741 cacattcaaa gcaacgatca atacagcaat cagccaagac accactgtga tccatttggc 472801 gttgatcaga gatcccatga tccgtttatt gcttgtaaac ataataagcg gaatgagggc 472861 aaaggcgatc ccgaaggaca gcacgacctg gctcagtacg agagcggtcg tcggattaac 472921 acctgacgcg atgatcaaga tcggcggaat gatcgtgata aaacgccgta catacagcgg 472981 aatgcggtag ttgataaatc cttgcataat cacgtcgcct gaaagtgtgc cgacagacga 473041 actggataga ccggcaacga gcagcccgat cccgaacaaa gccgcagaca tagggctgac 473101 aagatgtccg aattgctgaa atgcgacgtc gagatcctca acaaacaggc cgtttttgaa 473161 gaataatgcg gcagccacaa tcagcatact tgcattaata gcccctgcaa tcagcatcgc 473221 tattaaaata tcaataaatt caaacctaaa gatttttttc cgttctgcat cagttttgcc 473281 aaccacccgc cgctgtgtaa gggcagagtg taaataaatg gcgtgcggca taacagttgc 473341 gccaagaata cccgctgcaa gaagcacact gtcggtgcca tgaaacgccg ggacaaaaag 473401 gcccttcatc actgacacgg catcaggctt tgcgaaaaag gtctgcaacg caaaggcgat 473461 cacgaccaca aacagcatac cggcaatacc tgcttcaagt gagcgataac cacggcgctg 473521 aagctccaat atcgcgaaag aaccgatcgc cgcaataata gacgcttcaa gcatcggaat 473581 gccgaacagc aaatacagtc ccagagccgc tccgataaat tccgccagat cagttgcgat 473641 aatgaccaac tcgccctgaa tccataatcc gatcgagaca ggcttcggga attcttcacg 473701 ggcaacctca ggcagatttt tgcctgtcgc aataccgagt ttggcggata gggattgaat 473761 taaaagcgcc atgatattgg aaaataagat cacccataag agcatatatc cgtatttaga 473821 acccgccgaa atattcgttg cgaagttgcc gggatcaata taggcaatgg ctgctataaa 473881 tgcagggccg agaaaaggga gcagccctct gaatcctctg attttcccgt caagcgcatc 473941 ttggacggct ttggaacggg gagattgtgc tgtgatgtcc ttgttcatca tgtctcacct 474001 gaattctgtt tgtttttgcc gtacaacaaa gagtttcctt aaggcaaatt attttatcta 474061 catcatatga ccatcccggt ttcttgtcaa ccgaaaatgt tcaaaataca cttctgaatt 474121 tttccctgtt atgtaacatg atatgtaggg attcgtgata aggtcccata taaaaagaca 474181 tcgtttcatt tcgaaacgat gcctcctgta tctaatgagt ctaggcttcc ttccgcagcc 474241 cgcggaatat aaggcccagc aagaacacga agatggctgc cccgatgatg gccgggaaaa 474301 tagcaaagcc ggcgaggctc ggtccccatg tgccaagaag tccgtgccca atccaagcgc 474361 cgatcagccc ggcaatcata gagccgaaaa ttcctcccgg cagccggttt cctacaatgg 474421 cgctcccaat taatccgata acaattgcaa caactaatga aaccaaaaag ctaagcatca 474481 tgatcacctc tcataaatga tttaccaatc aataaccgct cctgatcatt tcgaaacact 474541 tgaaagcata ttcctttatg atcctgtttt aatctttctc tgcacactgc cgtcagctaa 474601 atgaacaatg acctcagtgc ctttatgcgc cgcgatttcc tttgcccgtt caatcgcttc 474661 tttctttgta tccttgattt cagacacacg tttggcgccc tcggctttga ctgcccagcc 474721 ttttttatgc ttaataacat gctctgcttt attcatgagc tcggggccgc tgccgctgct 474781 tggatcagca tcgcgttctg tctcatcatc atgcgtcagg aaatcatcaa tttcatctgt 474841 agaggcgttt tccgcccatt ccttcgcttt gcttgtcgca attggaatcg cgcgcccttc 474901 ctcatagcct tcatcaatca tcgcattcgc aatgtctatc gccttttttc tcaccggctt 474961 ctcaagattt tttaatgaag caggataatc cttcatcgac caaggcatgt ctatcactcc 475021 ttttcctttt ataaaaatgg tacccgcagg tgaaaaataa aaacgcatcc gaaaaaatga 475081 aggtatacta tatagtagaa aaaacggaag ggaagtgcgg gttgggtgcc aacagaacga 475141 aaagaagact tacatcagca attaaaagag atagagaaat gggaaaaaga tcagcaaaaa 475201 gtctggtttt gggaaaagct cagccgtctc ccgtttcaac tcctggacaa gctgacacca 475261 gaattcatcc agaaaaagat cggcaagctc ttggatgagg tcggcagctt tgttcaaaca 475321 ggcggacagt acctgacatc tgaaaaacag attatcagga tgtttcaaaa gaaactgccg 475381 gaggagatct ttgaatcgct ggaggacatc cggaaagcgc ctcttcctgt catggatgaa 475441 attgcggaag gaatgggcaa aaacagaacc aacgcagcaa ccgttcaagg cgcgacaacc 475501 ggtgtgggcg gcgtgtttac gctggcggca gacattccgg cagtgcttgg cttatcacta 475561 aaaacattac aggatatcgc agtcgcatac ggctatgacc caaaggagaa aaaagaacga 475621 gtcttcattg tgaaatgcct gcagcttacg tcggctgatg ttgtcggcaa aagatcgatt 475681 ttgcaggaat taaaacacta cgatcaagac cgtacatata agaatgtcgc ttctcaaatc 475741 caaggctggc gagaagtcgt tttgggctat cgagacacgt ttggctggaa aaaacttttc 475801 cagatagtgc cggttgccgg aatggttttt ggcgccgctg ccaatcgctc aacattaaac 475861 gacattaccg agacaggcat gatgctgtac aaaaagaggc gcattcttga acgactgaaa 475921 gaaacagaac gagagatgga atagcagaaa gcagacggac accgcgatcc gcctgctttt 475981 tttagtggaa acatacccaa tgtgttttgt ttgtttaaaa gaattgtgag cgggaataca 476041 acaaccaaca ccaattaaag gaggaattca aaatggcaga caataacaaa atgagcagag 476101 aagaagcagg tagaaaaggc ggagaaacaa caagcaagaa ccatgacaaa gaattctatc 476161 aagagattgg tcaaaaaggc ggagaagcca ctagcaaaaa ccatgacaaa gaattctatc 476221 aggaaatcgg cgaaaaaggc ggagaagcca ctagcaagaa ccatgacaaa gagttctatc 476281 aagaaatcgg tgaaaaaggc ggagaagcca ctagcgaaaa tcatgacaaa gaattctatc 476341 aagaaatcgg ccgaaaaggc ggagaggcaa caagcaaaaa tcatgataaa gaattctacc 476401 aagaaattgg ctcaaaaggc ggaaacgccc gcaacaacga ctaatcaaaa gcataaaggc 476461 agacaacctg taaataaaaa agcgatccgg cacatcagct ggatcgcttt tttttggaat 476521 cttctcaatt tatgccgcta ttgagataca ataagtgaaa aaggggtttt cgctaatgtc 476581 caagatgcaa aacttgctcg ccatcgcaaa tgaagtcaaa gaaaagcacg ccaatttttc 476641 aatctcagag gtcaacgacc actgcgtgcg ccttgcggtg tttacgggag aatatgactg 476701 gcaccatcac cctgactcag acgaattgtt tattgttctt gaaggggagc tgctgatcga 476761 ttttaaggac aaagaaaccg cggtgctcaa agcaaatgac agcctgctga tccctaaagg 476821 cacggttcac cgcacacgct cttacgtcag aacggtaaat ctctgtgtgg agcataaaca 476881 agccgaaacc gtcatcatag aggagcagcc atgctaatca aaaagatgat atgtgaagta 476941 gatgctgcaa acgctgaagc atttgcaaaa gcgcagtcac agtgggaagc gttatcgcat 477001 ataagcggct ttatcaaaca ggccggcggc tggcgaaaaa cgatagacga gccgctcacc 477061 gcagaaatca tcagtgtatg ggaaaacaga gaagcctatg atcattttat ggagaacgaa 477121 catgacagca tatacgagga aaacgatcag aaggctgtaa ttctttcgat agaggtgacg 477181 gtgtacgaag aggataaacc gttcgttcac gatctgttac ataaccccga tatccggtac 477241 gaaccaaact ggacggttct gaaggcataa tcaaagccca aaacatcatg ttttgggctt 477301 gtctctttac tcgcgtcccg gaagtgtatt atgaacaaaa ggcggtgctg gttttaactc 477361 cggtttttct ccaaacgttt ttgcttcttt cacatattca aaggcttctc cgtccggcgc 477421 tttttcattc agccagtttt gctcggcgct tacttcgcct tcagagaaat tgataagctg 477481 atgtgagaac tcttgttttt cgagcgcttt cgggaatgta cccggcacaa ccggaccttc 477541 ctgtgcttct aattctttaa tggcggcgag ccattggttc tggtgcatcg tgtcacgcgc 477601 cagcaggaag ctgagcatat ctttgacgcc tttgtcatcc gtcatttcaa acaggcgtgc 477661 gacctgcaga cggccctgag attccgcatt caggttggcg cggaagtctg ccagcaggtt 477721 tccgcttgct acgatataac cgccgctcca aggtacgcct gtactgcttt ccggcatggc 477781 gccaagtcct gatacaatcg catggtgagg gttcatgccg cctaggatgg agccgatgac 477841 cggatcttca gcagcttttt cctgctgatc aagaggggca tcctcaagaa gtctggcaat 477901 catcgttgcg atcatttcaa catgcccgag ctcctcagtt gccgtatcca tcagcaagtc 477961 cttgtatttt tcatttcctc ttgtgttcca gccttgaaat aagtactgca tggcaactga 478021 aatttctccg aattgcccgc ctaaaatttc ttgcattttt ttagcgaata atggatctgg 478081 acgatctggt ttagcaggat gctgcagcat ttttgtgtgc ttaaacatgt acccatctcc 478141 tttttcgttt atctcttttt atatttccga tcgatagaaa gataaacgaa aaacagcgta 478201 tcgagatggg aactatgaat cttttcgcag ctccaacagt tcccggatca gctcccggcc 478261 aaagatgggc tcatactgcc ggtaaacagg gtcaagacgc ttcatccatt cttgtttctc 478321 tttatctgac agctcataaa tatgtatagc agaattcttt ttgatttctt ccagctgctc 478381 cttgttcatt tgttcggcat acgtttcatt ccactccgtt gtctccttca tcgcttcagt 478441 caaaatgcgt cttgtttctg gtgtttgcgc cttccagaag tgttcatcag tcatgacagc 478501 gtagccgaga taaccgtggc tgcttattgt caaatagtcc tgaacattat aaaatttttt 478561 agaatagatg tttgaaattg tattttcttc gccatcgact acattgtttt ctaacagctg 478621 aaaggtagaa ttgaaggatt cctgatgagg tgttgcgcca agcagcttga actgatcctc 478681 aatcacatcg ctttgcataa tgcgcagatc ctgccctttt aagtcatccg gtgttttgac 478741 cggcccttga tttgttgtga tttgcttaaa gccgttcgtc caataggcca atcctttcaa 478801 ttggtttttc tttagagaat caaacagctg tgtgccgatg cttccgttca gccctttttt 478861 gacggcgttg taatctgtaa atgcatacgg cagatccagc actccccatt caggcgagag 478921 catgccgagc ttcgatgtgg agggggcgat aaattgaaca tcgccgtttt gcaatgcttc 478981 aatttcttca atgtccgagt acaggcttcc attcggaaat acttctattt ttatttttcc 479041 gcctgatttt tcgttcacca gatcagcgaa tttattggcg gccagccctt ttggcgtatt 479101 ttcagcaacc acgtggctga atttaaacac gatttgatcc tgcaggcctt cctggtcgtc 479161 atcataaaca atctttttat tgccggtatg atcatggaat ccgataaata aagcggttgc 479221 aattccagcg atcatcagtg cgagacatgc aagcaaactc ttcatgaaaa gccctcccct 479281 atgttaagga taatgggggc tatgacattc gtaaagacct gaaaggagaa gctgatgaac 479341 aaaaagaagc tctcaatccg ttggaaaatc acgatcttat cctatatact cgtcattttc 479401 tcctttttga tcggcggcat tgtgctcatc ggcaacattc agcatacaga ggagcgggag 479461 ctgaaaaagc ggctgatgaa tacggcccgg acggtgtcag agatgacaga agtgaaagaa 479521 gccttggcgc gaaaaaaaca aacagaagcg gttcgccatg cggttgaaga aatcaggatg 479581 attaatgaag cagactatat tgtcgtcatg gatatgaatc acatccgata tacgcatcct 479641 gtcagcacaa gcattggcaa gaaatcagaa ggtgcagacg aggaggcagc ttttgcggag 479701 cacatttatt tctctgaagc aaagggcgag atcggcacgg cggttcgcgc tttttatccg 479761 gtaaaggatc aagacctgaa ccaaataggc gtggtgcttg tcggaaaaac gctgccgggg 479821 atcgctgaca tcctgcttca tttaaagcgt gatatcgcct tcatcgttgt gctgacactc 479881 ggctttggcc ttgctggttc ctttttgctg gcccgccata tcaaaaaaca aatgtttcag 479941 cttgaacccc atgagattgt ccgaatgtat gaagaacgga cagcgacgtt tcactcgatg 480001 aatgaagggg tgatcgctat tgacaatcgt ctcgtcatta cgatcttcaa tgaaaaagcg 480061 aaacagatct ttgaagtgca gggggatcta atcggcaagg tgatttggga ggttctcaag 480121 gattcgcgcc tgcccgaaat cgtggagcgg aacaaagcgg tttataatga agaaattcgt 480181 gtcagcggta aggtgatcat gagcagcaga attccgatcg tcatgaagaa aaaagtgatc 480241 ggcgccgttg cgatttttca ggacagaacg gaagcggcca agatggcaga ggaattgact 480301 ggtgtcagaa actttgtgga ggcgctccgt gtccaaaacc atgagcatat gaataagctg 480361 cacacgatcg ccggtctcat ccagctgggg aaatctgaaa aagccttgca gcttgcattc 480421 caggcgtcaa ctgagcagga aaatgtgact gaatttctgc accgctcgat tcaaaatgac 480481 gctgcggcag gccttctatt aagtaaaatc agaaggggaa gagagctcgg cattgctgtt 480541 catatagatg aaaacagcag tcttcagcaa tttcccgagc atgttgatca gcatgatatt 480601 gtcgtgcttt tggggaatct gattgaaaat gccttcggct catttgaaac cgttcaatct 480661 gaagacaaac gaattgacat tagtatcgaa caaacagatg atatccttgc tattttaata 480721 gaagataacg gctgcggaat tgaaccgaca catatgcctc gcctttatga caaaggtttt 480781 acggtcaata aaactggcgg cacaggctat ggcctgtatc tagtgaaaca aatcatagac 480841 aaaggatcgg gcacgataga agttgattca catgcggggc aggggacatc tttttctatc 480901 gtttttccaa tgaaggggga ggaagcacag catggctcgt aaagaatgga aggttctgct 480961 cattgaagac gatccgatgg ttcaagaggt caataaggat ttcattacaa ctgttaaagg 481021 cgttactgtc tgtgcaacgg caggaaacgg agaggaaggc atgaagctga ttaaagaaga 481081 acagccagat ctcgtcattc tcgatgtgta catgccgaaa aaagacggca tcaagacctt 481141 gcaggagatc agaaagcaaa agcttgaagt ggatgtcatt gtcgtctccg ctgcaaaaga 481201 caaggaaacg atctcactca tgctgcaaaa cggggcggtt gactatatct taaagccgtt 481261 taagcttgag cgaatgagac aggcactcga aaagtacaag caatataaac aaaaaatcga 481321 agcgaatgat acgctgtccc aggaacagct cgatgcgatc ctgaatattc cgcagcaggc 481381 cgtacaggat ctgccgaaag ggttgaatca cttcacgatg aatgaagtca ctgctttttt 481441 gaaacagcaa accgcatccc tttctgctga agaggttgcc aaggcgctcg gcatcgccag 481501 agtgacagcc agacgatatc ttgattactt agaaaaaacc gggatcatca aattggacgt 481561 tcaatacggc ggagtcggcc ggccggtcaa ccgctacgtg ttaaaaggat aaacctgaga 481621 ccaaaaagac caaaatgtcc gttatgatca taaacttccc cagactgtat gaaaacgcta 481681 tcattctagt aagaaagaca caaaaggcga ataggacagg gggatgaagg atatgaaact 481741 gtttaaaaat ttaacagttc aggtcataac cgcggtcatc atcggggtca ttgtcgggct 481801 ggtctggccg gatgtcggca aagaaatgaa accgcttggt gatacattta tcaacgctgt 481861 taaaatggtg atcgcaccaa tcattttctt cacaatcgtt ctcgggattg caaaaatggg 481921 cgatatgaag aaggttggaa aagtaggggg aaaagcgttt atctatttcg aggttgtcac 481981 caccctcgca ctcattatcg gtttatttgt cgtcaatatt atgaagccgg gtgcgggtct 482041 tgattacagc aagcttgaaa aaggagatgt atcacaatac acgcaaaatg gcggtcaggg 482101 aatcgactgg attgaattta ttacacacat tgttccgtcc aacatggttg atgccttcgc 482161 aaaaggggac attttgcagg tcttattctt ttctattctt ttcggagtgg gtcttgcggc 482221 attaggcgaa aaaggaaaaa gcgtcattga tttcttcgac aaggtttctc acgttttttt 482281 caaaattatc ggctacatta tgcgtgccgc gccaatcggg gcattcgggg cgatggcgta 482341 tacaatcgga cacttcgggc tcgattccat caaaccgctg gcaagcttaa tgatgtctgt 482401 ttatattacg atgttcctgt tcgtatttgt tgctttaaat atcatctgca agctttacgg 482461 attcagcctg tggaattacc ttcgcttcat taaggatgag cttttgatcg tgcttggcac 482521 aagctcttcc gaatcggtgc ttccgcgtat gatggataaa atggagcgct acggctgttc 482581 caaatccgtt gtcgggcttg ttattccgac gggctattcg tttaacctcg acggcacatc 482641 catctattta tcaatggcga ctgtcttttt ggcacaggtg tttggagtag acctcagcat 482701 cggccagcaa attacgatta tcctcgttct gatgctgaca tcgaagggag cggcaggtgt 482761 gacgggaagc ggatttatcg tccttgcctc aacgctgtca gcgctgcagg tcattccgct 482821 ggaggggctt gcactcctgc tcggggtcga ccgtttcatg agtgaaggaa gagccattgt 482881 gaacctgatc ggaaacggaa tcgccacgat cattgttgcc aaaagcgaaa atgaatttga 482941 tgaagcaaaa agcatagagg ctgttgaagg catgaaaaaa atgaaaacag cagtctgaaa 483001 aaagaacggc ccatccatgg gccgtttttt taattgttta agaattatta aggtaaggac 483061 agagacctca gcattttttt gttatataat ttacaaatgg atactatatt gaatgaagga 483121 cgtttgtcct aacaggagtg tataaatggc cgctttagtt aaattttttc agcacccggg 483181 agtaaggcgt ttctccatct ttgtcgtgtt aactggtgtg ttatatctat ttaagagcat 483241 gatcaactta atattgctta ccttcatttt cacatttcta atggatcgtt tggagcttgt 483301 cgtgcggcag tttgtaagcc agttcttccg cgtgagccag cgggttgtca ttacgtttct 483361 ttacatgttg ctggctgtgc tgcttacagt cgggggcttt gtgttttatc cggtcgtcgc 483421 ggcgcagatc cagcagctgg taaagcagat taaacatatt gcgtatcatc ctgacagcat 483481 ccctttcttt gatgagatca ccagtgtctt cggagatatt aacatcagtt catatgtcaa 483541 agagggcttc aatgtagtgt atacgtatct ggccgatatc agcacattcg gcttgcaggt 483601 cgtgatggcg ctcattctta gcatgttttt cttatttgag aaaaaacggc tttctgaatt 483661 catggcgaaa tttaaaacga gcaaacttag ggtcttttat gaggagattg cttttttcgg 483721 aagcaaattt gcaagaacgt tcggcaaggt gctcgaggct caatttatca ttgcgctcgt 483781 caactgtatt ctgacgttta tcgcgctttg gattatgcat tttccgcagc tgtttgggct 483841 ttcgattatg gtgttcttcc ttggattgat ccctgtagca ggcgtcgtca tttccctgat 483901 tccgctcagc attatcgcct acagcactgg cggtggaatg tatgtgctct acattgtcct 483961 tgtcatattc gccattcatg cgatcgaaac ctatttctta aatccgaagc tgatgtcggc 484021 gaaaacagag ctgccaatct ttttcacctt cacagtactc attttctctg aacacttctt 484081 cggcatttgg ggtttaatta tcgggattcc gatctttgtg tttctccttg atattctgga 484141 tgtcaccaac aaggaagata ggtctaaagg accccgagag aatagcgata aaaagtagtt 484201 taaaatcgaa taatgagtgt gcctcgatct gccggcctgc ctgttcaggg catggaatta 484261 agactcggaa tcggagcttg gcattgcctt gcacagtggt gaacacaaca ggtgacaatg 484321 cttgtcatca gtacggaaac tgaaaagaac aaacagtcgg agcaaacgct catcatcggt 484381 ttaaccaaac atttggaagc aacaaatgct ataatacaaa cagtgcctaa tgttgggcac 484441 tgtttatttt ttgtcgaaaa aggaggaagg ctttatggct gagccgattt tacatattga 484501 aggcctcgat aaaaaaattg ggtctaaaca gattttaaaa cagatcagca tggacgtcat 484561 ggagggtgaa atcatcggcc ttctcggtcc gaatggttcc ggaaaaacaa cactcatccg 484621 tatcatcgtc gggctgttga aacaaaacag cggaagcgtg acaatcagcg gattccagca 484681 tgatacagag tttgaaaaag cgatggaagc ggttggagcg attgttgaga accctgagtt 484741 ctatccgtac ctgacaggct gggaaaacct caagcacttt gcgaatatgc acaaaaaaat 484801 agcggatgaa cggcttgatg aagtggtgga acgtgtcggg ctgacgtcag cgattcatga 484861 taaggtgaaa acctattccc ttgggatgcg ccagcgtctg ggaatcgccc aggcaattct 484921 tcaccggccg aagcttctca ttctagatga accgacaaac ggcctcgatc ctgcggggat 484981 gaaggatttt cgggatcata ttaaggaact cgcagaaatg gaaggaacag ctgtcctgtt 485041 cgccactcat ttattgcgcg aggttgaaga cttgtgcgac cgtgtcatca tcattcaaaa 485101 aggtgagatc aaagcggaag tcagcttaca aggaaccgat caaaccacag aaaaagcgat 485161 tatagaagtg cagccgcaag aaaaagcgct caattggctg acaggcaatc aatatcaagc 485221 tgagagccaa gacgggacga ttgtagttga ggtggcaaaa gaaaacatac cggagctgaa 485281 ccgatcactt gtcggacaag atctgaatgt attttccatt acgccttaca cgcagtcact 485341 ggaagacgaa tttataaaag cgacaacagc tcatcaagag gagggagaag agcttgtcta 485401 aattaatttg gaatgaacat atgaaacttt ttaatcggaa ggtcactttg gtttctctta 485461 tcctgatggc tgtctttcaa ttcttcatgg cattgatcat taaacggatt gtcatcagtg 485521 ccggaacaga tgaaaacttc atcggctatt tatcgtatac accgagcctg aacattttgc 485581 tgcaggcttt aacgatcgta attgcagcaa caattgtttc gatggaattt gataaaaaga 485641 cgatcaaatt tttgctcatt cgtccggtta aacgccaaaa ggtcttttgg tcaaaattaa 485701 tcacagtcgt gatggtcagc ttctatttgt atttggcata ctacattctg gcattattat 485761 tcggtctctt gttttttggc acatcggtga ctgcggaatc aaagacattg ctggtcaaca 485821 ccttggcgct gatcgggtca aactggcttg aagctgtaat gatgggatta ttcgggctgc 485881 tttgttcttc gctgttccgc aatagcgcgg tagcagttgt tgtttctttt gtcgttttat 485941 acggagcgag tacacttgtt cagctcatga agttgtttga aaacaagtgg ggcagctttt 486001 tgctttttgc gaacactgac tttacgcaat acagaagcgg agagacagcg ttgttttcag 486061 gcatgacgcc attgttttca attggaattc tcatcataca tgccatattc ttcatcgttg 486121 ttggctggtg gtgcttctgt aaacgggatg ttcgggtcta aaggcaagga atgacatttt 486181 tgtgaaaaag ctcacgtaaa tcaatatcat ttgatatttt ggtttatact aaaggtactg 486241 acggaggtgt ctcgattgag gaactttatt accgctttac cgatcgtatt gctgcttgga 486301 ttctcatttg tgtcattcat gtttcagttt gaacatcttg tttatttcag gctcgcgctt 486361 gggttgtttt ctctcgtggg actgtacatg atatataaaa tgaagacggg catccgctat 486421 tttatcatct atctgtatgc cagctggatt gtgttggccg cagtgaccgc ttttgaagag 486481 ccgattttct caagcttttt ctttggcggc ctggtgatga cgatgggtta cctgacatat 486541 atgctgattt atctcggcat gaaacaagac cgggatgcaa atcctgtgta atcgcgctgt 486601 tcccttgggg aacggcgtgt ttttctatac tgggcaaaag gttaacagtt gcggaaaaat 486661 ggcaggaaat ctataataca tattaaattt atcggaatta aaactggggg gctgccggat 486721 gtcattattt atacaaaacg atcaacagcg gcaatggatg gagaaaatcg gacggattgc 486781 ggatgaattt cagcaaacag ctgctgaaga tgacgaacag ggacgttttc ctgcagagaa 486841 aatacaaaaa ctgcgtgatg ctgggtatac agcattaaca ttgccggcat ctcatggcgg 486901 agggggcatt tctgtttacg atatgctctt gtttcaagaa cggcttgcac ggggagatgc 486961 tccgacggct cttagcatcg gctggcattt gagcgtgatc ggggagcttg gagaaggcaa 487021 cagctgggat gaagacgtat ttgcatttgt tgccaaggaa gtccaaaacg gagccgtcat 487081 taacagggcg gcgactgaag cgaaaaccgg aagcccgaca agaggagggc gtcccggtac 487141 acacgccgtc aaaaaggatg gcaaatgggc agtgaacggg agaaaaacct ttacgacgat 487201 gtcacaagct ctggattatt ttttagtaac cgcatggatt gaggacaaac aaacaacagg 487261 cgtgtttctc attcataaag atgatcccgg cttgtcgatt gaagaaacgt gggatatgat 487321 ggcgatgcgg gcgactggga gccatgacct tgtactgaac gaagtaatgc ttgatgagaa 487381 taagctggtg gaactgcttc aagggcctcg tggagctaag ccgaatggct ggctgcttca 487441 cattcctgcg atttatcttg gtgtggctca agctgctcgt gactatgcag tgcaatttgc 487501 atctgagtat tctccaaaca gcttgaatgg accgatcaag aatgtcccgg ccgtacagca 487561 aagaacaggc gaaatggagc ttgaactgct caatgccaga cactttcttt tccatatcgc 487621 tcaattgtat gacgatccgg tgcggcgtcc acacttgacc agcgagctcg gtgcggcgaa 487681 acatatcgtc acaaacgctg cgctgtctgt tgttgataaa gcgatgagaa ttgtcggggc 487741 caaaagcctg gaacgaacca acccgcttca gcgctattac cgtgatgtgc gcgccggtct 487801 tcacaacccg ccgatggatg acgccgtgat acacaagctg gcagctgaag cgtttgagtc 487861 ataaaaaaaa gagccttacc ggctcttttt atgtattgtt ttgctcttgc agattttttt 487921 gatgcttgcg gtcgatcctg tcataaataa cgttcatcag ctttggattg cccataatcg 487981 cctctttgtt ttcctggatc agctgttggt aagttttcac tttacgcttc ggcatgctcc 488041 ggcgccctcc tgacatgttt gtattcactt tctaactccg tcagcgacaa ttcatacaga 488101 tgacgctttg actttttgta tataccattc tgtattaaca gatgaatgag ctgttttttt 488161 ctgatttctg cagactgagg tgtcattgtg tcaccaacct ccaatcaaac gatattgata 488221 atcattatca attaacttca gtatacaatg tccgcaatag cctgtaaaga tgaaaagagt 488281 cctattcttg gccaatttac aaacattcaa caaatcgaca aaaagtttcc cgggcaataa 488341 tttgctgtcg aaatattccg cttcattgaa cgcaccctgc tatttttcat gttttgaacc 488401 atactatgta atagaatgga ggctggtatt caatggagcg gacagaaaat ctgaaaaagg 488461 gagaaaaagg ggcgctcctc aatatttttg catatgtcat ccttgctgtt gtaaagctag 488521 ttatcgggat tctatatcat tctgaagcgc tgagagcaga cgggttaaat aatggaacag 488581 atattgttgc gtcagtagca gtgctgatag gattgcggat ttctcaaaga ccggctgaca 488641 gcgatcatcc atacggccat tatcgggctg aaacaatttc gtctcttgtt gcgtctttta 488701 ttatgatggc agtcggcatt gaagtgttaa tcggcggagg aaaagcgatt gcgggcggca 488761 caacggaaac gccaaatctt atcgcggcat ggacggcgtt aggcagtgct gtgtttatgt 488821 atggcatcta tttatataac aaaaggctgg cagcgtccat taaaagctct gccctgatgg 488881 cagcggcaaa ggacagcagg tcagacgctt ttgtaagtgc cggcgcgttt atcggtgttt 488941 tttcgtccca gctgaagctg ccgtgggttg atccggtaac ggcttttatc atcggcatca 489001 tcatttgcaa aactgcgtgg gatatcttta aagacgcttc acattcctta acagacggct 489061 tccatttaaa agatcttgag ccttacaaac agaccgtcgg caggatcgaa aatgtgcatc 489121 gcctaaagga tgtgaaagcg aggtatttag gcagtacagt tcatatcgag atggtgatta 489181 cggttgatcc gaagcttaca gtagaagaag gccatggagt ggcggatgaa gtagaagaca 489241 aaataaaaca tgaacacgat gtcactcatg ttcatgttca tgtagagcct gacgacataa 489301 aataaggctg tttaacgaat tagcttatat gttcagataa aaattcagtc acttcttcag 489361 gcgttttggc attggcgctg tgaaggtgag ctgttttttc accgttcttg aaaataagca 489421 ggctgggaat gcccattact tggtattttt cagccaggtc aggaagctcg tccttattca 489481 gctcatacca gtcgttttgg ttgtattctt ccaaaatatc gccgatgaac atattcatgc 489541 gtgtgcagtc tgggcaccaa tcagcataaa actttacaat gatttcttta tcagattgaa 489601 tcagttcatt aaattgttcg tttgttgtga tttttttcat atgtcacatc tccttttcaa 489661 tgccatttta atataaaata aaaaggaatt acatacaaat gcattcaaca tcagcatgcc 489721 caaaaataat tagatcattt tccggtgaaa atgataagat agtaaagatg aattgtagtg 489781 gggggagtat ccattgaaaa caagtctagg attagtgtac ggaggaaagt cggcagaaca 489841 taatgtttcc ctgcagacag ctctggctgt aatcaaagcg ctaaatactg agaagtttga 489901 tatacatccg atttatataa cagaaaaagg cgaatgggtt agaggcgccc gtttaactga 489961 acctgtttca aacgtgaaaa tgcttcaatt tgagcaagga ggcagtgctt tttctccagc 490021 tgccctgaac caggagatgt ttccgcagga agcgtcacag caaaatgaag ccatcgacgt 490081 cgtattcccg ctcctccacg gaccgaacgg agaagacggt acgatccagg gaatgctcga 490141 gctgttgaac attccttatg tcggcaacgg agtgcttgct tcctcagctg gcatggataa 490201 agttgtcatg aaacatttat ttgcgcaggt tggccttgct caggctaaat acgcagcttt 490261 ccttaagaaa gactggactc gttctccgaa agaaagctgt gaggaggttg aacaggaatt 490321 aggctaccct tgcttcgtaa aaccggcgaa cctcggctca agtgtcggaa tcagcaaatg 490381 ccgaaaccgt gaagaactgc aaaaagcgtt tgagcttgct ttccaatatg accgcaaagt 490441 cgtcgttgaa gaaggaatta acggccgcga gatcgaaatc ggcgttcttg gaaatgatga 490501 tcctaaatgc tctgttgtgg gagaaatcgc accgaagaca gatttctacg attacaaagc 490561 gaaatatgag gatggagata ctgatctgat gattccggcg attgtgactg atgaggaata 490621 cgcaacaatc agtgatatgg cgatcaaagc gtttaaagcg atcgacggtt caggactcgt 490681 cagagcggac tttttcctga cagctgacgg cgaagttctg atcaatgaag tcaacacaat 490741 gcctggcttt acacctttca gcatgttccc gttgctctgg aaagaagccg gagtggaata 490801 tgctgacctg attgaacagc ttgtggagct tgcaaaagaa cgccacgctg aaaaacaatt 490861 gattaagcat acattctaat gaagaaggac actgccggta aaagggcagt gttttttccc 490921 gtatatacaa aagaaagaga gggaccttac ttgattaagc gaacagtaaa aaacattgcc 490981 gaaatggtta aaggcacact agcaaatccg caatatgaac aaacagtcat tcatggagtg 491041 gcaaccgata caagaaaact ggaacaacat cagctcttta ttccgctgaa aggggaacgt 491101 tttgacggcc actcttttgt ggagcaggcc tttgaagctg gtgtagcggc tgttctttgg 491161 gatcggtcag taccaaatcc gcccgagaat cacgccgtca ttttagtgga cgataccctt 491221 actgcacttc agcagcttgc aaaagcttat ttgcaggagc ttggcacgcg tgtcatcgga 491281 gtaaccggaa gcaatggcaa aacgacaaca aaagatatga ttcacgccgt attggggacc 491341 cagtaccgtg tccacaaaac tggaggaaac ttcaataatc atatcggttt gccgctgacg 491401 gttttagcga tgcctgaaaa tacggagatc gccgtattgg agatgggaat gagcgccaaa 491461 ggagaaattg acctcttgag ccgactggca aacccggatg cggcagtgat tacgaatatc 491521 ggcgaatcgc atatgcaaga cctcggctct agagagggca tcgcggaggc gaagcttgaa 491581 atcataaacg ggcttaaaga agacggagtg ctgatttata tcggggacga accgcttctt 491641 caaaatgcat acagctgcca gacgaaaacg tacggtacgg gaacgcataa tgattatcag 491701 cttcaggatg tcagccagag tgaggaagga acccatttta caatcaaagg gatagaaaac 491761 acgtttttta ttccaatact cggcaagcac aatgtgatga acgccatggc tgcaattgct 491821 gcaggggctt attttggcat cgcgcctgag gatgcggcaa aaggactgag cggcctaaag 491881 gtaaccggga tgaggcttga actcatcaaa acagacagcg gcctttcgat aatcaatgac 491941 gcttataatg cgagcccgac ttccatgaaa gctgcaattc aattgacaga aagccttgaa 492001 ggctacggca aaaaaatgct cgtgctcggt gatatgcttg aactcggcga tcttgaagaa 492061 acgttccata aagagtgcgg cgctgtgatc agccctgata aaattgaccg cgtctttacg 492121 tacggaaaac tgggagcttt tatcgcggaa ggcgccctga aacactttga gaaagaccgc 492181 gtcagccatt acactgagaa aaaagatctc cttcaagctg tgaaggaaaa cgcatcaaaa 492241 ggcgatttga ttttattcaa agcgtccaga ggtatgaagc ttgaagaaat cgttaaagat 492301 ttaatagaga gcccgctttc ataagaaaat attttgcgaa aaaacgcata ttgcatcata 492361 aaataacctg atatgcaaac actaatgtat gccggccgaa aattatgtat atctggccgg 492421 ctgcggctat gatacaatat atataggtta tttcgcgata cgaacatatt cgtccggact 492481 tttcatcgtg acccgaagtt ctccgctgga ttcttgggag cggatggagc agcagccggc 492541 atattcgaga tgccgatctg cttctcatct tattgaaaaa caaatagtgt aatggtaaga 492601 taaaacttaa agtaattcgg gctttgtata cggatggatc ctgtccttct tgtctaaagg 492661 gcagttttat aagtggtaaa tcacgacatt actgaaacag caattagaag gagtttgaat 492721 aatttgacta taacgtttca agattttaat ttaagttctg atctcatgaa agcaattaat 492781 cgtatgggat ttgaagaagc aacaccgatt caggcacaaa cgataccgct cggactttca 492841 aataaagacg tcattggaca agcgcaaaca ggtacaggta aaacagctgc gtttggtata 492901 ccccttgttg aaaaaattaa ccccgagtct cctaatattc aagcaatcgt aatcgcgcca 492961 acccgtgaat tagccattca agtatctgaa gaattgtata aaatcggaca agataaacgt 493021 gcgaaggttc ttcctattta cggcggacag gatattggac ggcaaatccg ggcgttaaag 493081 aagaatccga atattattgt cggaacacct ggacgtcttc ttgaccacat caaccgccgc 493141 accattcgtt taaacaatgt aaataccgtt gtaatggatg aagcggatga aatgctgaac 493201 atgggattca ttgacgatat tgaatctatc ctttcaaacg tgccaagcga gcatcagaca 493261 cttctgttct ctgccacaat gcctgcgccg atcaaacgca ttgcagagcg cttcatgact 493321 gagccggaac acgtaaaagt aaaagcgaaa gaaatgacgg tttctaacat tcagcagttc 493381 tatttggaag tgcaagaacg taaaaaattc gatacactga ctcgccttct tgatattcag 493441 tctcctgagc ttgcgatcgt attcggacgt acaaaacgcc gtgtcgatga gctggctgaa 493501 gctctgaacc ttcgcggata tgcagctgaa ggtattcacg gtgacttaac gcaggcgaaa 493561 cgtatggttg cgcttcgtaa atttaaagaa ggcgcaatcg aagttctagt cgcaactgat 493621 gttgccgctc gcggacttga tatctcaggt gttacacacg tatacaactt cgacgtgcct 493681 caagatcctg aaagctacgt tcaccgtatc ggaagaacgg gccgtgcagg aaaaacaggt 493741 atggcgatga cgttcattac accgcgtgag aaaagcatgc ttcgcgcaat tgaacaaaca 493801 acaaaacgca aaatggaccg catgaaggag cctacacttg atgaagcgtt agaaggtcag 493861 caacaggtta ctgttgaacg tcttcgcaca acaatcagtg aaaacaacct gaacttctac 493921 atgacagcgg cagctgagct gcttgaagat catgatgcag taacagtggt tgcggcggct 493981 atcaaaatgg ctacaaaaga gccagacgac acaccggttc gcttaacaga cgaagcgccg 494041 atggtcagca aacgctacaa gaaccagcgc tcttctaaac gcagagacgg tcaaggcggc 494101 ggctaccgcg gcggaaaagg gaaaagcaac aaccgttctt cctatgacaa aaagcgttca 494161 aacgatcgcc gttcttcagg tgacagacgc cagaaaaaat cttactaatt tgatcgattc 494221 agagcccaaa acatgatgtt ttgggctttt ttatgttcgt gatttgttat tcagcaaact 494281 ttcagctgac ggaagccatt tttctctgta tgcttaagaa tgaaaccttt ctgtaaaaga 494341 gacgtataaa taacgacgaa aaaaagggag gtaggtattt ttgagagagc agccaaaaaa 494401 ccaaatcagt ccagacggat taaaggtttg gcgacttcaa gagatcatca tatccgctgt 494461 ttgcttgctt attgtcattg cagttgcagt gttaagctat tattttcatt ggccgtactg 494521 gatcagcggc gtgctcggcg ctgtttggct gctgggatcg attgtgacgg tctttatcat 494581 tccgaaggtc cgtcataagg tgtggcgata tgaagtccat gaacatgaaa tagatattca 494641 gtcaggtatt tttgtggtga cacgtgtgat tgttccgatg gtcagagttc agcacgtcga 494701 tacgtcacaa gggccattat taaaaaaata caacctggca acggtgaaaa tttccacagc 494761 cgcgaccgtt cattcgatcc ccgctttaga gatggaggaa gcggatcggc taagagactc 494821 catttcccgt ctggcgaggg tgactgacga tgatgtctga accgaaacgc ctgcacccgg 494881 tggcagtcat tttgaattta tgccatacca ttattcaaac gataaaaaat atcattctgc 494941 cattcttttt tgtgtatatt gtcaattcaa accatactgt ccgtttttac ggagccattg 495001 cgctcggtgt gctgttcatc tggcttgtag cggcaagcat tatcaaatgg agaaggttta 495061 cctatcgaat tgaagatgat gaatttagaa ttgaagaagg cttatttgtt acgaaaaaac 495121 gatacatatc gattgatcgg attcaaacaa tgaatacgag cgcgggcctt gtccagcaaa 495181 tctttaagct tgtgaagctg caaattgaaa cagcaggcgg aggcaaggag gcagaagccg 495241 ttctttctgc tatttctgtt gaagaagcgg aacgcatcaa agaagctgtc tttaagaaaa 495301 aagcgcaaag acgagaaaat gaacttgatg aagaacggct tgaagctgaa gaggagttgg 495361 atccgtccgt tgaggtgcaa gagcactatc gcatgaacgc gaaagaattg ctcatggccg 495421 cttctacctc cggcggaatc ggagtcatta tctccgctgt atttgcactt atttcccagc 495481 ttgatgaagt gctgccgatg gattggttat tcgataaatt ttccttcctt cagcacgcca 495541 gcatcggtat ttatgcggta ctcattttta tcggtttatt tatcgcctgg attttcagca 495601 tcgcgggcat gatgtttaga tacgcgaact ttcaaatcat aaaaaaagag caggaactgg 495661 tgatttcaag gggaattatt gaaaaacatc aagtcacgat tccgctgcga aaaatacaag 495721 ccattaaaat caaagaaaat atcattcgcc agcttttcgg ctttgtaacg gtgtccatcg 495781 tcagcgcagg aggcggcgac cgggaaaaag aagaaggcgc tttgaccatt ctctttccaa 495841 tgattcataa aaaaaagctt ccgcacatgc tccgaacatt tacgccggaa tacacgctgg 495901 aagaaaactg ccgccgcctg ccgcggcgcg cgttgaaacg ctatttgttc cgttctgtca 495961 ttttttcact ctttttgatc atcccgttat gtatcttctt tcagccatgg ggctatctgt 496021 cagtgatcct gctgccgata gaattgctct tcggctatct cgcgtataaa gaggctgcat 496081 ggacgatcaa cggggaccgt cttcagctga cgtctagatt tataggcaga acaaccgcca 496141 ttgtactgaa aaaacgaatg caggtctgca agttcagcca atcctatttc caaaagaaag 496201 gccgcttgta taccatttct acttcggtga aatcatcgag ccatatggaa gagttaacgg 496261 tgagggacgt aggtgaagag gatgcagcct tcattttaaa gtggtactca tatgaaaaag 496321 cggacggtta ataccgccgc tccagcgtgt cggcaaaccc tcgcattcgt tgtcaggact 496381 gcgcttcggt gctcaatgcg aagtggatca acggctaaat tctcaggcgt cctgcctaaa 496441 cgccgtcgtc atcacatcct gtgaaagtcc gctcctatgc tcgtccttcc tagacttcat 496501 gggttttcaa tcacgctgaa aagatgacaa aatcctaaaa tgaaaaccat tttaggattt 496561 tgtcaacaat ctgaagcggc ggttaatacc gccgctcttt tttttgcacg cataaaaacg 496621 aaagaagaaa cccgccgcat agtccaaaca aatgggccat catgttaata ttggagttga 496681 taaacgacat gagaacggca aatgcgagca gtgtgatgat cattttggaa tgctcctgcc 496741 caattaactc attgcgaaaa agaaccataa acaggtatac gccaaatagc ccgaaaatgg 496801 cgcctgaagc cccgacatgc acgtaatcaa gcggctctgt aacataagtg ccgatattgc 496861 cgatgatgcc ggagccggcg tatacaagaa ggaaacgcgc ttttcccagc atgcgttcca 496921 aagccggggc aaataaaaag atggacatgg aattaaacag cagatgtgtg aaaccggcgt 496981 gcagcaaaat cggtgtgata agccgccacc attcaccgtt tgcgacacct agattatagc 497041 ctgtgacggt atccctccat aacacgactg aatgggcagg aagtgaaaaa aacagccaga 497101 gaacagcttg caaagccaat ataaaggtga caacggggta aagcctgata aatgtttgaa 497161 aattttcagt ccgtataaac attccgagcc ccttttcttc attttggtat atctatagta 497221 acacgtttat gagacaaacc atttaaatag tacgtacgca aaggaggtta tcatacatga 497281 tttacggcat tgggctggac attaccgagc ttaaacggat cgcctctatg gctgggcgcc 497341 agaaaaggtt tgccgagcgg attttgacgc gaagcgagct tgaccaatac tatgagcttt 497401 cagagaaaag aaaaaacgaa tttctcgcgg gcagattcgc ggcaaaagaa gcgttctcga 497461 aagcatttgg caccggcatt gggaggcagc tcagctttca ggacattgaa attaggaaag 497521 accaaaatgg caagccctat atcatttgta cgaaactgag ccaggccgcc gttcacgtat 497581 cgatcactca tacaaaagaa tacgctgccg cgcaggttgt gattgaaagg ttgtcaagct 497641 agtctgcata ttagggaaac cccactcata tatttgatag tgcattaagg gagacaagtt 497701 gtttgaggct tttatggtac gcatctgttc tgcctaaacg tgtaccgagc gtaccgttaa 497761 agtcaaacaa gcgatttctt ccttttacat caattgagaa aaaggggttg aaaaaggtga 497821 gaaaaagctt tgttttgctt ttaacgggac tgcttgctgt tcttattctt tctgcctgcg 497881 ggcaaaaaac acagcaagat attgtggccg ggttagatga aaaggcgaaa gaatacacct 497941 cgtacaaagc aaaagcgaaa atgaccatcg agacagggag tgagcctcaa gtatacaatg 498001 tggaaatctg gcacaaaaag ccgtctctgt acagggttta tttagaaaat ccgaaaaagg 498061 accaaaacca agtcatttta cgaaatgaaa acggagtatt cgttctcacg ccgtctttaa 498121 ataagagctt cagatttcaa agcgattggc cgaacaacag cagccaggtt tatctgtttg 498181 aatcgctcgt aaaggatgtt caaaacgatt cggatgcagt tttcacagcg aaagaaaaga 498241 aatacgtatt tgaaacaaaa acaaactatc agcataacaa aatgctgccc acgcaagaaa 498301 tcacatttaa caaaaaagat atgagcccgt catctgtcaa agtgatggat actgaccgga 498361 aagtgatggt caaagtagaa ttcagcagct ttgaatttaa taaacaattt gataaagaat 498421 catttgatga aaagaaaaat atgacccttt ctcaaatgga tgtcgccaca agcgcaaagc 498481 cttccgatac atttgcggtc aaaacgccgc tggaactgcc gcttggcgtc aagctgcttg 498541 aagaaaaaga tatatctact gaagacggga agcgcatcat catgacgtac ggaggagaaa 498601 aatcatttac gttaattcag gaaaaagccc agattgccaa ggcttcctcc tccgttacgc 498661 tgaacggcga accggtaaat ctcggctaca ccatcggcgc cctgtcggat gcatcattat 498721 catggacata tgacggcgta gattaccttc tctcttctaa agatctttct aaagaggaaa 498781 tggtgacagt agcgaaaagc atgcagggac aatcatcgaa ataaccgcca aaggccaaac 498841 atgatttggc ctttttttcg ttagacatcg tttcccttta gcctttaatt ttagtatgat 498901 atgtaaatga tattgaataa aagctaggaa gtgtcgtaat gagcacaaaa cctttttaca 498961 gagatacgtg ggcggaaatt gacttgtccg cgataaagga aaatgtcagc aatatgaaaa 499021 aacatatcgg tgaacatgtc cacttgatgg cagttgtgaa agcaaacgcc tacgggcatg 499081 gtgatgcaga aacagcaaag gctgctcttg acgcaggtgc ttcatgcttg gccgtggcca 499141 ttttggatga agcgatttca ctgcgcaaaa agggattgaa ggcgcctata ttggtgcttg 499201 gcgcggttcc cccggagtat gtggcaatcg ctgctgagta tgacgtgacc ttaacaggtt 499261 attctgttga atggcttcag gaggcagccc gccacacgaa aaaaggttct cttcattttc 499321 atctgaaggt cgatacgggg atgaacagac ttggtgtaaa aacagaggaa gaagttcaga 499381 acgtgatggc aattcttgac cgcaaccctc gtttaaagtg caaaggggta tttacccatt 499441 ttgcgacagc ggatgaaaaa gaaagaggct atttcttaat gcagtttgag cgctttaaag 499501 agctgattgc tccgctgccg ttaaagaatc taatggtcca ctgcgcgaac agcgccgctg 499561 gactccggct gaaaaaaggc ttttttaatg cagtcagatt cggcatcggc atgtatggcc 499621 ttcgcccgtc tgctgacatg tcggacgaga taccgtttca gctgcgtccg gcatttaccc 499681 tgcattcgac actgtcacat gtcaaactga tcagaaaagg cgagagcgtc agctacggag 499741 ccgagtacac agcggaaaaa gacacatgga tcgggacggt gcctgtaggc tatgcggacg 499801 gctggctccg aaaattgaaa gggaccgaca tccttgtgaa gggaaaacgc ctgaaaattg 499861 ccggccgaat ttgcatggac caatttatgg tggagctgga tcaggaatat ccgccgggca 499921 caaaagtcac attaataggc cggcaggggg atgaatatat ttccatggat gagattgcag 499981 gaaggctcga aaccattaac tatgaggtgg cctgtacaat aagttcccgt gttccccgta 500041 tgtttttgga aaatgggagt ataatggaag taagaaatcc tttattgcag gtaaatataa 500101 gcaattaact tacctaaatg gagaattcat aaaacagctt tgcttgaaga gtgaataatg 500161 gtatcattat cactggatgg ataaaagagt cgtatccgta agtttggtgg aggtgtatgt 500221 tttttgtctg aatccagcgc aagaaccgaa atgaaaatca gcttgcccga aaacctagta 500281 gctgaattgg atggtgtagc gatgcgggag aaacgaagca gaaacgaact gatatcacaa 500341 gcagtgagag cgtatgtcag cgaacgaaca actcgtcaca accgtgattt gatgagacgc 500401 ggctatatgg aaatggcgaa aatcaacctg aatatttctt ctgaggctca ctttgcggag 500461 tgcgaggctg aaacgacagt tgagcgctta gtcagcggag gataatcatt tgattgtgaa 500521 acgcggcgat gtttattttg ctgatttatc tcctgttgtt ggctcagagc aaggcggggt 500581 gcgcccggtt ttagtgatcc aaaatgacat cggaaatcgc ttcagcccaa ctgctattgt 500641 tgcagccata acagcacaaa tacagaaagc gaaattacca acccacgtcg aaatcgatgc 500701 aaaacgctac ggttttgaaa gagattccgt tattttgctg gagcaaattc ggacgattga 500761 caagcaaagg ttaacggata agattactca tctggatgat gaaatgatgg ataaggttga 500821 tgaagcctta caaatcagtt tggcactcat tgatttttag acatatttgc aggttgctca 500881 aatagagcaa ctttttttgt tttcaaaaaa cataaacgat ataatagtga aataacgaaa 500941 aaatatgttg ttttttattg ggaggtaagc gaatttgatg tcgaaccaga ctgtatacca 501001 gttcattgcc gaaaatcaaa atgaactgct ccaactgtgg actgacacac taaaagaatt 501061 aagcgagcaa gaatcctatc agctgactga ccaagtgtat gaaaatatat ctaaagaata 501121 tatcgacatt ctgctgctgt ctgttaagga cgaaaatgct gctgaaagcc aaatcagcga 501181 actggcgctt cgagcggtcc aaatcggact gtctatgaag tttttggcta ctgcacttgc 501241 cgaattctgg aagcgtctct acacgaaaat gaatgataag agattgccag atcaagagag 501301 cacggaatta atctggcaga ttgatcgctt tttcagcccg attaacacag aaatttttaa 501361 tcaatactca atctcatggg aaaaaacagt atccctgcaa aaaatcgcgc tgcaagagct 501421 gtctgcgccg cttatcccgg tgtttgaaaa tatcactgtg atgcctcttg tcggaacaat 501481 tgataccgaa cgcgcgaaac gaattatgga aaaccttctt aatggcgtcg tcaaacaccg 501541 ttcccaagtc gtgctgattg acattacagg tgtccctgtc gtcgatacga tggttgccca 501601 tcatattatt caggcatcag aagctgtaag gcttgtcgga gcaaaatgcc tgctggccgg 501661 aatccgtccg gaaattgctc aaacaatcgt caacctgggg attgatttat cccaagttat 501721 aactaagaat accctgcaaa aaggaattca aacagcattg gaaatgacgg atcgaaaaat 501781 cgtttcattg ggggaataac attttgagac atccgaaaat cccgatcttg aaactgtata 501841 attgcttatt agtgtccatt cagtgggaac ttgatgacca gacagcatta acttttcaag 501901 aagacttatt aaataaaata tacgaaacag gtgctaacgg agtcgtcatt gacctgacat 501961 ctgtggatat gattgattca tttatcgcga aagtgctggg ggacgtcatt acaatgtcta 502021 agttaatggg ggctaaagtc gtcttgaccg gcattcagcc cgctgtggca gtgacgctga 502081 ttgaacttgg aatcgcgctt gaggaaatcg aaactgcgct cgacttagag caggggcttg 502141 agacattgaa gcgggaattg ggggaatagc gaatgaacga ccaatcctgt gtaagaatca 502201 tgacagaatg ggatattgtg gccgccagac agctgggacg aaacgttgcg aaagaactgg 502261 gtttcggcac ggtagaccag gctagaatta caacggctat ttcagaatta gccaggaata 502321 tttatttata tgccggcaaa gggcagattg gaattgaaca ggtcgcagac agaggaaaaa 502381 aaggcctgaa aatcatagcg gaagaccaag ggccgggaat tcctgatatc cgaaaagtca 502441 tggaagacgg gttttcaacg tctggaggac ttggtgcggg acttcccggg gtcaaaaggc 502501 tgatggatga attcagctta aattccgtag cgggggaagg aacagagata caagccatca 502561 aatggcttcg gtaggaggta agaacgtgga ttttagggag gttattgagc agcggtatca 502621 tcagctgctt agtcgatata tagccgaatt aacagaaaca tctttatatc aagcccaaaa 502681 attcagccga aaaacaatcg agcaccaaat tcctccggaa gaaatcatca gcattcacag 502741 aaaagtgctg aaggagctgt atccaagtct cccggaagat gtgtttcatt cgctggattt 502801 tttaatagaa gtcatgattg gctatggaat ggcttatcag gagcatcaaa cccttagagg 502861 gatacagcag gaaatcaaat cagaaattga aatcgcggca aatgtccagc agacgcttct 502921 cggaactaaa gttcctcagg aggaagcgct ggatatcggc gccatcagtg ttcccgctaa 502981 acagatgagc ggtgattact accactttgt caaagacaag gaatccatca atatcgcaat 503041 cgcggacgtg atcggaaaag gcattccagc ggctttatgc atgtccatga ttaaatacgc 503101 aatggactct ttgccggaaa cgggcataca cccttctcaa gtgctgaaaa atttgaatcg 503161 tgttgttgaa caaaacgttg atgccagtat gtttattacg atgttttatg cgaattacaa 503221 tatggacaag catcaattta catatgcttc agcgggacat gaaccgggat tctattattc 503281 tcaaaaagac aacacgtttt acgatttaga ggccaaagga ctcgttctcg gcatctcgca 503341 ggactatgac tacaaacaat tcgatcagca tctggaaaag ggcgatatga ttgttttatt 503401 ttctgacggc gtcacagaat gcagaacgga aaacggtttc ttggagcgtc ctgatctgca 503461 gaagctcatt gaggaacata tgtgttcctc tgcgcaggaa atggtcaaaa acatttatga 503521 cagcctcctc aaattgcagg attttcagct tcacgatgat tttacgttaa ttgttttgcg 503581 gagaaaggtt taacgtctgt cagacgaggg tataaagcaa ctagtgattt gaaggaaaat 503641 ttgaggtgat acgaatgaat ataaatgttg atgtgaagca aaacgagaat gatatacaag 503701 taaacattgc aggagaaatt gatgtatact cagccccggt gcttagagag aagctcgttc 503761 ctctggcaga acaaggagct gacttaagaa tttgcctgaa agatgtcagc tacatggaca 503821 gtaccggatt gggcgttttt gtagggacct ttaaaatggt gaaaaaacaa ggtggttcgc 503881 tgaaacttga aaatctttct gaacggctga tccgactgtt tgacattaca ggcttgaagg 503941 acatcattga tatttctgca aagtcagaag gtggagtgca atgaagaata atgctgatta 504001 catcgaaatg aaagtgccgg cccaacctga atatgtggga attataagac tgacgctgtc 504061 aggggtcgca agcagaatgg gctatacgta cgatgaaatt gaagacttga aaatcgcagt 504121 cagtgaggcg tgcacaaatg cggttcagca cgcttacaaa gaagataaaa atggggaagt 504181 gtcaatacga ttcggtgtgt ttgaagaccg tttagaggtt attgtggcgg atgaaggaga 504241 cagctttgac tttgatcaaa agcagcagga tctagggccg tacacacctt cgcacacagt 504301 tgatcaatta tcagaaggag ggctcggtct atatttaatg gaaacgctca tggatgaagt 504361 cagagtgcaa aaccactccg gcgtcaccgt agcgatgaca aagtatttaa atggggagcg 504421 agttgatcat gacacaacca tcaaaaacta cgaaactaac taaagatgaa gtcgatcggc 504481 tcataagcga ttaccaaaca aagcaagatg aacaagcgca ggaaacgctt gtgcgggtgt 504541 atacaaatct ggttgacatg cttgcgaaaa aatactcaaa aggcaaaagc ttccacgagg 504601 atctccgcca ggtcggcatg atcgggctgc taggcgcgat taagcgatac gatcctgttg 504661 tcggcaaatc gtttgaagct tttgcaatcc cgacaatcat cggtgaaatt aaacgtttcc 504721 tcagagataa aacatggagc gttcatgtgc cgagacgaat taaagaactc ggtccaagaa 504781 tcaaaatggc ggttgatcag ctgaccactg aaacacaaag atcgccgaaa gtcgaagaga 504841 ttgccgaatt cctcgatgtt tctgaagaag aggttcttga aacgatggaa atgggcaaaa 504901 gctatcaagc cttatccgtt gaccacagca ttgaagcgga ttcggacgga agcactgtca 504961 cgattcttga tatcgtcgga tcacaggagg acggatatga gcgggtcaac cagcaattga 505021 tgctgcaaag cgtgcttcat gtcctttcag accgtgagaa acaaatcata gaccttacgt 505081 atattcaaaa caaaagccaa aaagaaactg gggacattct cggtatatct caaatgcacg 505141 tctcgcgctt gcaacgcaaa gctgtgaaga agctcagaga ggccttgatt gaagatccct 505201 cgatggagtt aatgtaatga tccaggttga agaaaacgag catattcaaa ctctagtata 505261 tcaactgaat aaagaaggga aatcgatttg cggtgacagt ttttttatga aagctgatga 505321 taaggagtta atttgcgcgg ttgctgacgg actgggaagt ggatcacttg ctaacgaatc 505381 ctctgcagcc atcaaagact tagtggaaaa ctatgcgagt gaagacgtag aaagcattat 505441 cgaacgctgt aatcaggcga tgaaaaacaa aagaggcgct acagcatcta tcctgaaaat 505501 caattttgag caaaggcagt ttacgtactg ctctgtcgga aatgtacggt ttattctgca 505561 ttccccgtct ggtgaaagct tttatcctct gccgatttcg ggctatttat caggcaagcc 505621 gcaaaaatac aaaacgcaca ccgccaccta tgaaaagggt tcaaagttca ttatacatac 505681 agatggactc aacgtacctg atatccgctc ccatttgaaa aaaggccaat cggtagaaga 505741 aatatcgaat tcgctgaaaa tgtatacgac atcgagaaaa gatgacctga cctatattct 505801 cggacagctg tcctaaaaaa ccagaaaaag aagctggaca tccggcttct tttttttgcg 505861 gttgactatt aataagtgcg cttattatac ttaataagtg aacttatcat tctgggagct 505921 tatgggatgt ggaattatga atacacagcg atagctgatg tggatgtggg aaaacctgga 505981 actgttatca ggaaacagaa acaatggatc aatgggagac gggtattgca tcagattctt 506041 tgaaaggaca atttcaaaat ggaacggaag gaacattgct tctgcaagga aaaacaattc 506101 tcttatggct tgagcatgtg gagaaacatc gggcgttttc tgtcatggtc aacatgcccg 506161 catagcaatg taataatgga gttttttcac gtgcttcaaa agcaaaaaga agatttgtgt 506221 atcacatatg gaattgtatt agaaggcgct gaagcaaaaa agtggggaga aatcattggg 506281 actgaactgt ctaaagacat gccgacggct gtcagcaggc ttgtccatct ttacggagga 506341 gtgataaaat gaacacaaat tactggatcg gcgttgtgtc agagcaacat gtattaaaag 506401 gcgctgccgg cggttttgca cagctgtgcc atggaaaaaa agccccgctc gccaaaatga 506461 aagagggaga ttggctgatt tattattctc cgagagacgc atatccagac ggcaaactgc 506521 tgcgaagctt tactgcgatc ggcaaagtaa aaagcggaaa catctatccg tatcaaatgg 506581 ctccgaattt tattccatac cgattagata tagactatta tccatgccat aaaatcggtt 506641 tttacgacat taaatcaaag cttgaatttg ttcaggaaac caagcatctt ggctttttat 506701 ttcgcagagg acactttgaa ataagcaaaa aagatttttt gacaatagca caagcgatgg 506761 gagttaacat aagtggaatg gcactctaaa tttagcggtc cgaacacaag cccgggcttt 506821 ttattatggc aggccacgca aagttggcag cggaaagtag gaaaagcatt ggctgagttt 506881 gacctgaccc acgttcaatt tgttctgctg acctcgtgca agtatatgat tgctcacgga 506941 gaaaccgtca cgcaaaaaaa acttgcaagc ttcagccaga ccaatatcat gatggtttcg 507001 gaggttgtgc ggacgcttga gaaaaaagga tttatcgaaa gaagcaaaaa tccccaggat 507061 aaaagagagg tcctcctgtc tcttacagaa ataggaggag aaaaagtaac agcggctttg 507121 ccaattgttg agaagattga tcaagccttc tttgcagctg cgatgaaaaa agagaatttt 507181 ctgagcggct tacaggaact attgaaacat gagtaaagat acgggcagcg ccagctgtct 507241 ttttttatgt gtttttttcg gtttttgata cactagagaa agaacgacaa aattggaggc 507301 tttggttaca tggaaacgtc agccctttta aaacagcaaa ttgcgaaaga aataggttta 507361 tcacaaaaac acgttgaaag tgtcatccgc ctgcttgagg acggcaatac agtcccgttt 507421 attgcccggt atcgaaaaga gcagacgggt tcaatggatg aggttcagat tcagacgatt 507481 tctgaacgct ggcaatacat acaaaacctg aatcagcgaa aagaagaagt catcaggctg 507541 attgcagagc aggataaact gacagataat ctaaaacgta aaatcgagca atcggtgaag 507601 cttcaggaag tggaagacct ttaccgccct tataaacaaa aacgtaaaac aaaggcgaca 507661 gtcgccaaaa gcaaaggcct tgagccgctt gccgactata tcctgacact tccccaagat 507721 gatcatctgg cagcaactgc agaccaatac atcagcgaag aaaaagaagt gttcacacga 507781 gaagaagcga ttgaaggcgc caagcacatt attgcggaac aaatctcaga cgagccgacc 507841 ttcagaaagt ggattcgcca ggaaaccttc aaaagaggaa ccattaagtc tgcagccgga 507901 aagtcggcag acaccgatga gaaaaatgtg tatgaaatgt attacgagta tgaagagcca 507961 attgcaaaag ttgttccgca tagggtgctg gcaatgaacc gcggcgaaaa agaagacatt 508021 ttaaaggtag cgatcgaacc gcctgcggat cacattaagg cgtatttaga aaaacaaatc 508081 atcaaaaatc gctcaacatc cgtaagagag attttgcagg agacaattga agacagctat 508141 aaaaggctga tccagccggc aatcgagcgt gaaatcagga aagagctctc agaaaaagct 508201 gatgaacagg cgattcatat tttctcagag aacttgagaa agcttctttt gcagccgccg 508261 atgaaaggca aaaccgttct cggtgttgac ccagcctttc gaactggctg taagctcgct 508321 gtgtcagatg agaccggaaa agtcttgaaa attgatgtga tctatccgca tgcgccagtc 508381 aacaaaacaa aagaagccca tgaaaaagtg aaaaagattc ttgagcagta tcaagtcgag 508441 atggtggcga tcggaaacgg cacagcatcc agagaaacag agcaattcat cgtcaatgta 508501 ctcagagaca tgccgcgcaa aatttattat gtgatcgtca atgaagcggg agcaagcgtc 508561 tattcggctt cagagcttgc cagagaagaa ttccctgacc ttaaggttga agagcgcagt 508621 gccgtatcta ttgctcggag acttcaagac ccgctcgcgg agctcgttaa gatcgatccg 508681 aagtctgttg gtgtcggaca gtatcagcat gacgtcagcc aaaaacgctt aaatgaatct 508741 ctgcggtttg tcgtcgaaac tgtcgtaaac caggttggag taaacgtcaa cacagcctcc 508801 gccgcgctgc ttcaatatgt agctggatta tcgaagtctg tagcaggcaa cgttgtcaaa 508861 aaacgtgagg aaatcggaaa gttttcaaat cgaaaagaac tgaaggacat cccaaggtta 508921 ggtgcgaaaa cctatgagca atgtatcggt ttcttaagag tgcaggaagg gacagagcct 508981 ttggatagaa caggcatcca cccggaaagc tataaagaaa caaaagcact tttgaaaaaa 509041 ctcggacttt caacagaaca tatcggcacg gcggaattga aggacaaaat caatcagctg 509101 gcgctctctg aaacggcaaa agagctggga atcggcgaaa tcactctgaa agacatttgt 509161 gaacagctga caaggccgga acgcgatcca cgcgataagg tgcctaagcc tttgctgaaa 509221 acagacgtcc ttcagctgga agatttgaaa gagggaatgg aactgcaggg caccgtgcgc 509281 aatgtagtgg acttcggagc gtttgttgat atcggagtca aacaagacgg gcttgtgcat 509341 atctcaaaat tgagcaatca attcgtcaag catcctcttg atgtcgtatc tgtcggcgat 509401 attgtgacag tttgggttga cggcgtagat gtacaaaaag gcagagtatc gctgtctatg 509461 gtaaaataaa agcactgctt acgagcagtg ttttttccta tagaaatacc agcattgatt 509521 cagcagttta atttggtaat tatctttttc aaggaacgct ttttgcatct gctttttaag 509581 ccaatttggc ataggctcat tcctcctcag cttttatcat aagagggaca gtgattacca 509641 tattgtatgc gaacggtgaa ttgtcccgtt caatgttttt taagtgaggt gcaccatgga 509701 taacaaagag cttcaaaagc tgacagagga tatttctgaa acatatttta aaaagccgtt 509761 ccgccatcag gcgcttttta atgaccggct taaaaccact ggcggcaggt acctgttaac 509821 ctcccataac attgaattga acagaaaata tttgattgaa cacggcaggg aggaactgat 509881 tggcatcatc aagcacgagc tctgccatta tcatcttcat cttgaaggaa aagggtacaa 509941 gcacagagac agagatttta gaatgctatt gcagcaggtc aacgcgccga ggttctgtac 510001 accccttaag aaaaaagcgg aaaacaaaaa aacttatatg tatatctgta cgacctgcgg 510061 ccaacagtat ataaagaagc gcgccatgaa ccctgacaga tacagatgcg gaaaatgccg 510121 cggaaaaata aaaagaattt tttcgtgaaa aaggttgacg aatatggcaa gcctatgtta 510181 cattataaaa gtcgtcacga gagataaata aaaacattta cctcttgaca ctgcaaatca 510241 aggctgatat aataagtctt gtctcattat tccacagtag ctcagtggta gagctatcgg 510301 ctgttaaccg atcggtcgca ggttcgaatc ctgcctgtgg agccatattg gagaagtact 510361 caagtggctg aagaggcgcc cctgctaagg gtgtaggtcg cgtaagcggc gcgagggttc 510421 aaatccctcc ttctccgcca taagatttcg atataagttc tcaaccatcg gcccgttggt 510481 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc 510541 attccatttc gttgggctat agccaagcgg taaggcaacg gactttgact ccgtcatgcg 510601 ttggttcgaa tccagctagc ccagccattt ttatttttga aatctaatag taagagccat 510661 tagctcagtt ggtagagcat ctgactttta atcagagggt cgaaggttcg agtccttcat 510721 ggctcaccat ttgtcttttt gcgggtgtgg cggaattggc agacgcgcta gacttaggat 510781 ctagtgtctt acgacgtggg ggttcgagtc ccttcacccg cactttattt acaaagtgca 510841 cgcaaatctg ttttactagg ttaagagcct actaaaccag cacaacacaa tttaatgatc 510901 acgcggtcgt ggcggaatgg cagacgcgct aggttgaggg cctagtgggt gaataacccg 510961 tggaggttca agtcctctcg gccgcatctc aataatacca agggtttaac cacctttggt 511021 attatttttt tgtgtggaaa atacggctat gggagaagac ttgctcacca aaactcacca 511081 gttacttaaa gtaagtcatc caaacggtcg gcggttcctt ctgtttatta ggaaaaagat 511141 atccgttcat tgtaaaagaa acgaaccatg tcctattcgt tcaaaaaaac taaagggtga 511201 tacatattat acatgattaa tatgtatcac ccttttcttt cttgttcaac aatcgcgctt 511261 gaggagaaca taagctaata caactgactc gatttctaaa gttgctccat tcttttttta 511321 aacaactcat ccacaacctg ttttaaaatc tcgtacgact gaatttcctt gctcaattcg 511381 taaatattag ataacacaat taattcatct gcgtgataca tttgttggaa atcaattagt 511441 tcgcgacgaa ttgtttctcg atcacccatg attgtatacc ccagtcgact gtggagaatt 511501 tctaattcaa actgtgataa cgattctagg aagttttcag tgggtggaat aagcttactt 511561 aaattatttg tataaatatc aatatacacc tgcaaatgac ttgcagaaat aaaagatgcc 511621 tcgtctatag attctgctgc aatcacatta atgcaagcga tcacataagg ttcttgtaaa 511681 taagaagacg gttggaaatt ttctcgataa atagagagcg cttcttccat cgaatggggt 511741 gaaaattgag cgccaaatgc atagggtaaa ccaagctttg cagcaatttc cgctgaatcc 511801 gttgaggatc ctaacacaaa aacaggcaca tgcgttccaa tacccggata agcgcgaacc 511861 tcaccctgta cactcttatc cccgacaaaa cgcaaaatat catttacttc tctttcaaag 511921 aaaaacactc cattatggtt ggaacgacga atcacatcgg ccgttttttg atccgttccg 511981 ggtgcgcgtc ctaatgccaa atctacacga tttggatata atgtttcaag tgttccaaat 512041 tgctccgcta cgattaatgg ggaatgattt ggcaacataa taccccctga acctacgcga 512101 atgtcttttg tatttgctaa tatatgttgt acaattgata cggttgctgc acttgcataa 512161 gcgtcgtgat tatgatgctc tgcaaaccaa atccgtttat agcccatatt atctacagct 512221 ttagctaatg acactgcaga atcaatccct tgtttcattg tttctccttg tcttaatgga 512281 gcaactgata aaacagatat atcaaatttt ttcataattt cacctctaaa ataatgaact 512341 tatacaagat caatggaaaa aacattttga aaaattgttt catattaaat ggtgtccatt 512401 cctctttgat ttgcatgcaa ataaatatat actttctcaa acgatcaata cataggcaaa 512461 ataaagttat ttcacaattt cactttactt ttaaagtttt aagcaaacat aaaaaaatgt 512521 tcagtgaaca aaatatgtaa aatacatctt atttttcaga aaggatacaa gaaaatgatt 512581 gatgaaatag ataaaaaaat acttgatgag ctgtctaaaa atagtcgcct tacaatgaaa 512641 aaattagggg aaaaagtaca tctcactgca ccagcaaccg catcaagagt agtaaagtta 512701 atagacaatg gcataataaa aggatgtagt atcgaagtga atcaagtgaa attaggcttc 512761 tctatacatg cttttcttaa tatttatatc gaaaaaatcc atcatcaacc ctatttagct 512821 tttatagaaa cacaagataa ctatgtaata aacaattata aagttagtgg agacggttgc 512881 tatttgcttg aatgtaaatt tccttcaaac gaggtattag atcaattttt aaatgactta 512941 aataaacatg caaactataa agtgtcgatt gttattggta aatagttaac tttataaaac 513001 ggagatgtgc ggtcatataa catgatatat atgctctaaa aaagccctag gttggatatg 513061 gaatttacca agctggggcc tttttataca ttataataac aagcgcatta ttcatcagac 513121 attaatgaag tattataatg cttttttact tccttaatag acaaataaag ctgatagttt 513181 ccatacttca ataaatcatt cagaaggtga tttaaaactt cttgtgaatg aaccgttacc 513241 ttcagaagat aacatgcatc tcccgaaaca cgatgagctt cgctaatttc attacgagta 513301 gcaataaatt tcaataaatc atcatgcata tatgcattca tgaaaaagaa gacaaaggct 513361 gtaaaagaaa accccatctt caattcatca accacaatcg aatatgcttt aatgataccg 513421 ttatcctcca tttttttgat gcgattgcct accgcttgtc ctgtcatatg aattttttca 513481 ccgatttctt tccattgtat ccgagcattt ttatttaata attggagaat ttgaaaatca 513541 attgaatcaa tttgcatagt aactcctttc acagtgaaaa agttttacaa aatagtattt 513601 catgagacca tcgaaaattc aatggaaatt atatatcctt atacagtata aaaattttaa 513661 gaggtgaaaa aatgacaaca gctttattag tgattgatat tcaaaatgat tactttccaa 513721 atgggaagat ggctttaaca aacccagaga aagcagcaca aaatgcggct aaactacttt 513781 cacactttag aaacacaggc gcacctgtct ttcatgtaca gcatatcaca gaaggtaaca 513841 tcgctcattt tttccatcca aatacagaag gtgtcgaaat tcatgagtca gtacgtccat 513901 tagagaaaga gacagtcatt gtaaaacata tgccgaatag ctttttcaat acagatttaa 513961 atggaaagct acaagaagaa ggggttaaag aattagttgt ttgcggtatg atgtcccata 514021 tgtgtattga tgcaacagtt cgttctgcag ttgaacatgg ttatgtatgc caagtggtag 514081 aagatgcttg cgcaacaaca acattgcaaa ttgaagataa aatcgttcct gctgagcatg 514141 tccattacgc atttatggcc gcattaaatg gtgtctatgc aacagtaaaa accacagagg 514201 catttttaaa ataaaagaat ttcctgcgcg aacataacgt ctttcttttc acaagaaaga 514261 tgattcaaca acttaaaaaa ggatgttcag aaaaatactt ctggacatcc tttattcatt 514321 atcttttatt gtttttcagt atcattattc ccatctgata aaagatcaag atgtcctgtt 514381 tttgatccat agtaagacca tatacaggga ttgtttttgc cataaatata gatattgatg 514441 aaggtttaca taaagcacct aattgcttga tttactttaa tgttagatcc ctcaataact 514501 ccattctctt ctaatttctc tactctagct gtagctgctg ggcatgttaa atgtactctc 514561 tcccagatct ttcattgaat tcggctatta tacataattt ctctataatt ttttatctgt 514621 ttgatctatt tgaacgttaa ttcctttcga aaataaagtc aaagagttaa aacacttttt 514681 tttatctatg tattcgaaca ctgctgatat tatacactta actctgtcga tctaagacaa 514741 ataaaaaaag aaagtgagtt gtaaatatga atattacaca aattcgaaat gcaacaattg 514801 ttgtaaaata cgcaaataaa aaatttttga tagatcctat gttagcagag aaaggtacgt 514861 acgctacttt ccctgaaacg atcagacaag atttatttaa tcctttggtg agtttgccaa 514921 catcaattga taacattctg gatggcgtag atgcggtaat tgttactcat ctacacctag 514981 atcactttga tgatgtggca aaaaacgtat tgccaaaaaa catcaaaatg tttgttcaaa 515041 atgaagcaga tgcaaaagaa gtaaaagcaa gtggtttcaa aaatgtagaa gtgctacatc 515101 aagacactgt ttttgaaggg atccaattag taaaaacaaa aggtgaacat ggcagagggg 515161 aagagttatt aaacttaatg ggtgatgttt gtggattagt attcaagcac ccaagtgaaa 515221 aagttttata tgtagctggg gatacagttt ggtatgatgc tatcgaagac gagattcata 515281 cacatcaacc agaaatcatt gtggttaatg gtggagacaa tcaaagatta gatttaggtt 515341 cactcatcat gggaaaagaa gacatctatg aagttcacaa ggctgctcct catgctaaga 515401 ttatatctgt tcatatggaa gctgttaacc attggacact atctagagaa gaattaaaaa 515461 actttagtaa agaaaaagga ttctcaagta atattttagt gccagaagat ggcgagtctt 515521 acacatttta atatgaacac cgacaaataa atagaagaag ctcataatta taaaaactaa 515581 tcatgagctt cttctaataa tgaatatttt aaattttaaa tatatcgaaa atcctaaata 515641 tacggaataa caaaaatgga atgttccaat gatgacaaaa aaacttgaaa agcaacaaag 515701 atgtgtcgtt aggaggtaga attcatggta atgacaaaaa aagatacaaa tatatcaaca 515761 cagcagcctc tttggttaca aggttatatt gattcaccag aaaaacaaaa ccaactttat 515821 aaaaaaacat taaaaatctt gattttttca caaatatttg ggggagcagg acttggagct 515881 gggataacag ttggggcgct tcttgcacaa gatatgatag gatcggaaaa tgtagcagga 515941 attccaactg ccctctttac ttttggatct gccgtagctg ccctgcttat aggagcatcc 516001 tcacaacgtt ttggtcgcag agctggactt gcaggtggtt tccttatagg cggattaggt 516061 gctataggtg tgataatcgc ggctttaatt aacagcgttg ccctattatt tgtttctctt 516121 cttatttatg gagcaggtat ggcttctaat cttcaagttc ggtatgctgg gacagacctt 516181 gcaaatgaga aacaacgggc aactgctgca agtatggcct tagtttctac tactttagga 516241 gctgtagtag gtcctaactt agttaataca atgggggaat ttgcagattc aattggtgtt 516301 cccaatttag ctggtccgtt tattatgtca ggagcagctt ttataattgc tggaattatt 516361 ctcttaattt ttcttcgtcc agatccgctg tttgtatcaa cagctattgc gaatgctgag 516421 aaaaaagacg ataaagtaca aataggagga agtctaaaaa atcctgctat agacaaaaaa 516481 ggaataatgg taggagctgt cattatgatt ttagctcaac taatcatgac agctattatg 516541 acaatgacac cggttcacat gggtcatcac ggtcatggtt taagcgaagt gggattagtt 516601 ataggactcc atattgcagc gatgtatctt ccttcaccat tgactggttt attagtagat 516661 aagtttggtc gcacaactat ggctattgct tcaggtgcca cacttcttgc cgctgggttg 516721 gtggcagcta ttgcaccggc agactcatta tcattgctaa tcctagcact agtattacta 516781 ggggtaggtt ggaactttgg tttactaacg ggaactgccc ttattataga ttcaacacat 516841 ccatctctac gtgcaaaaac acagggaaca ttcgatgttt tattagcact atcaggagca 516901 gcaggtggag ccttgtcagg aatggttgtt gcacattcta gttatacaat actatcaatt 516961 tctggagccg ttttatcatt gttactcatt ccagtagtta tttggtattt tagaaggatt 517021 caggaaaaag cataagctta tataactgtc tttgaagaac ctaagtagac attactttac 517081 cggaacctcc tttttctatt tattatagta aggagttgac atggcattag tggcatgtgt 517141 ataactacac aattatttgg gattcagaga gcatgtaatg aacggaagag ataattattt 517201 atcactttta ttattgtacg gtgttcttgt ggcattaagt tcagtcaatt ttggtctaac 517261 tgttttcttt ttgttttcat cacctctcca tattattaac aaacacgaaa aggattttaa 517321 tgaaaataaa atgattagcg tatgtatctc taattttcaa aatgaatgaa tagtcctttt 517381 taagatttac acacttattc tccaaggaaa aatgactcaa tttttcgatt ttttatgtaa 517441 atcaaaaaag aatcatgtta gagtaggtgt gctgaaaata attcaaaaaa ttattttgcg 517501 atatgattaa agtaatattg ccagagagtt tcaattggac aaaattgtaa gtgtttaata 517561 cactggggct gcaatcaaat atgcacctgg aatcaattgc taaacggggg agtttatatg 517621 aacaacaaga aaaatatctt tgatattgtt atgtacatta ttttcggtgt gttaagtctt 517681 tttctagttg caaaaactga ttatggcact ggagttttag tgtttgttgc aattttatac 517741 ctcgctgtta ttgcttataa aattaagcaa gtatttagta attcagattc ttaaggtgta 517801 acacaaggag gatttcaatt gagaaagaaa agagttatta cttgtgttat ggctgcatca 517861 ttgactttag gctcactttt acctgcaggt tacgcttctg caaaggagga ctctaagaca 517921 accccttctt acgaagaact agctctacat tacaaaatga aaagtgaaaa gatttcatcg 517981 aacgggaaat tagttgaaat tgagtatgtg agtggaaatg aaactcacaa agttcagatg 518041 aacggaaata atcatactgt aaaagtcgat ggcatagaac aaaaaggttt aaactttgag 518101 tatgatgaaa atgttgctaa aagaacaaat tatgaaaaca ataatttgaa atcaaatgaa 518161 ttcacaacac aggctgcaaa acctaaaaag ggataccatt atgtggggac tttatctggg 518221 catacaaaag cagctaaaaa tgcgttatca gttacaatgt cattagtcgg tattgtccct 518281 ggcttgggat gggggagtaa ggctgccact attttattct cttattgggc aaaagaacaa 518341 atccctgatg cgtattataa atatgattta tacgaaaaag gagcaatgac tgatagttgg 518401 tatcagtatg ctacagttca attttttgaa gataaagctc ataaaaagaa aatgggcaaa 518461 ccttggacaa gtactcctgc aaaagtagat ttacctaata gctaatttta aaatcacttt 518521 gtctttataa aggacaaagt gattttttgt tatacagaag taaaatccct cgtctgagga 518581 atcttggaaa aaacttggtt caattttgat ataacatgtt tttttcttgc taatttagtt 518641 tttctatgta tcgctacaca ttctaaataa taagatatta gccggacggt tgatgccaag 518701 ctcaaaagtt tatatggaag tcaaagcata aaaaagggtg ttacaacgtg tagtcttctt 518761 tttattttgc caacgtaaca agtgtgaaag taatgatttg taggatcagt taagaaaggt 518821 ttaagattag atattgaaaa attttatata ttttcaataa aatactggta ctataataaa 518881 tgtatacaga ttgtatggag atgtaattaa ttaaaaagga gttttttaat tgcgttggag 518941 taaatggttc aatgtttttt gtatagtagc attgggatca atatatggtt ataaattatt 519001 tactaaccaa gaagtcagta ctactcgttt aataatagct tctgtaattg tgttgtggaa 519061 tattgttgga ctttttagca aagaatcagt aaaacaagca cagcaagcaa attaaaagtc 519121 ataaagttgg gaaagaagga tgttacttat gtagtatcct tctttattat tccttgaaaa 519181 atgaaacaaa ttggagatta cagcttatat aatcaattga agtcgttgat tattttcatg 519241 aacaggagat ttaatgcttt ctgatgaaat attatcgtat gaatgttgca agaggaaacg 519301 ttactcaaag attacaggga tgtgatgaac actcctcttt atcgcactca cctgacccca 519361 aattgttggg gaagggcagg tacggaagat agagtatttt ttcttcgtaa caaatcgaaa 519421 aggttggata ataaaaaact tataatctaa ggcggtatat agttgtgaaa aaggcgttat 519481 ttcttatatt agaccagtat gcagattggg aaggtgttta cttagcatct gcattaaatc 519541 aaagagaaga ttggtcggtt cacactgttt ctttagaccc tattgtaagc tcaataggtg 519601 gttttaaaac atctgtcgat tacataatag ggttagaacc tgcaaatttt aatttgctag 519661 ttatgattgg cggggattcc tggagtaatg acaataaaaa actattacat tttgtaaaaa 519721 ctgcatttca aaaaaacatt ccaatagcag cgatatgcgg tgcagtggat tttttggcga 519781 agaatggttt gctgaataat catagccata caggtaattt tgtttactta tggaaagatt 519841 acaaacaata taaaccgatt agcagttttg tagagaaaca agcagtaaga gataaaaatt 519901 tggttactgc taatggaact gcccctattg aatttactaa tttaatttta gagatgattg 519961 attttgatac tcctgagaac atagagaaaa tgatgtatat gaatcgttat ggtttttatc 520021 atttttgtga taaatatgga aatccatttg ttgattaatt tgctggaaat gattttcccg 520081 aatagggggc tttgcgattg agttgaattt cctaataaag caaagaaaga tgatttgagg 520141 tcaagtttaa caaataatgc catcaatatt aatttgcagt tatttccgat tcctgatata 520201 ataaagaaga attatttttg ttcggtgtaa aggatagtat gaagattgac ttttcgtctt 520261 gatgatactt tgggcaagga tagtatatac tgtgtggtta cacactagga ggcaacaaaa 520321 atggaacaag gtacagttaa atggtttaat gcagaaaaag gttttggctt tatcgaacgc 520381 gaaaatggag acgatgtatt cgtacacttt tctgcaatcc aaagtgacgg attcaaatct 520441 ttagacgaag gtcaaaaagt atcgtttgac gttgagcaag gtgctcgtgg agctcaagct 520501 gctaacgttc aaaaagctta atcttcaatc gtttatacaa acaggctctt tatatagggc 520561 ctgttttttt atgtctatat catactcaat aaaaaaccct actcaacgtt cgagtaggga 520621 gatgctacaa ggtaatagaa aaagatttaa aacttcaaag gtttgtttac agtataacat 520681 actggattga caatatgcgg aatgtatata aattatttaa tgttttgttc aaatatagat 520741 aactgactct ttttttcact aacctgttcg ttcatttaag taagattaga tgaattataa 520801 aaatggtttc atctaaatgt tatcaactcg catatctctt ttatgagaag aagataaaca 520861 attattattc aatgttgcag tggatataag aaattcttaa aaataatgag gagatcgatt 520921 gtttttttct cctggaaata atcacttaga gatacctaaa acaatgaaag ccctacctct 520981 cttccatcct tacggctcct tgtccgtgcc agtgtgaatc aggatactaa aaaaagtgac 521041 tattttattg agttttttgg taaaacttca atcttcgcag aagaaatgta aataataaaa 521101 atggattaga atgtaggaat aacaaaagag gtcgttaatg ttctaaacat aagttggaga 521161 agatttgctt ttcatcataa tattccgaaa tatcttttgg gatgtatcta accaaaactt 521221 tttatttgtt tttcagtgat tcctttaatt acttccagtt cactaatcaa aaattcatat 521281 gcattatcca gcattttttt ttcgcttgca ttaagtgctt tttctttctt catacgcatt 521341 aaatcacgta caacttcagc accttcttgt atttcacctg tttttatttt gtccgtgttt 521401 attttgtacc tttgcttcca tggcagtaac ctatcggatt ctccatgctg aaaaatgtgc 521461 ataatgtgtt ttaatgcaag tatatcggta actggtcgta tattcgaact caatatttta 521521 ctcgttggaa tcataactgt catattactg attgacattc ttatgacata atactgttgt 521581 ttttcctcta agaattcttt ttcttctatg gcttcaatta tacctgctcc gtgcattgga 521641 taaacaatgt tatcgccaat ttgaaacata tcatccacct ccatatatgg tatccttctt 521701 aagattacca tatatggagg tgtaatatca aaattttaat aataacatga tcgaattttt 521761 gatgtcaata acttttttga aaaaacagat caagcaaaaa caatagggaa cgtgtcggat 521821 ttccaatcag gaaaaggtca attgatccgt gtgagcagtt tttcattggc tcaatgacat 521881 tacagaaatg atttgagtag ataagaaaga acgatattcg tgaaatgtca gctaaaaata 521941 tttaaagcac atgattaagt tctaatttct ttaccgattt gatatggata acggccgact 522001 tacttaatga tgcattttca cttatcttgc aagcagaaaa aggtttgttg ataaacattt 522061 agccaccaaa ttggcattat tatcagggaa attgacaacc ttcaaatggg tattgaggcg 522121 agaagaaaaa taaagaaagg agagattata aatgaagacc agaacataaa gaagtaaagg 522181 ggaaagaaca aggttaattg aaaagcaaac tatataaaat agtttgcttt tttttgttat 522241 gacttcactt ctttttcttt ctctttaatg actaataaaa caccgctcag aattaaaaac 522301 gaacctatcc aaaatgtccc gcctatttgt tctccaagca gaatccatcc gagtaaggtt 522361 ccaaccagag gctgaaaaaa gaaaaagagg cctccacttg aggcatttaa taattgtaag 522421 ccgtggttcc acaataaaaa tgcacaagct gttgaaacaa ttcccaaata caaaaggcca 522481 cctagaattt tagggtcaag cagtagtggc gtaaaaatcg tgctagggga gtaccattaa 522541 cagggactcc atttattaat agaataaact ttatgaattc atttttttgt atgataatgg 522601 cgtcatattc atcgcttgtt gaaatttact tatgaaataa ctggtactgt taaatccaac 522661 ttgataagac acttctgtca cattggattc agggtgttgc agtaataata agcttttttg 522721 aattctataa tccattacat aacgtaatgg cgtcttattc agcattcgtt taaaataacg 522781 gcagcattca gaacggctca gttggccagc ttttgcaatg tcctctaatg tgattttttc 522841 aacataatgg agatggatcc agtttaacat ttgtttcatt cgatgacttt ttatcatttc 522901 agattgatcg tactctaatt gaaaaccatt aacgaccagg tttttccaca ttaacgttaa 522961 ttgcatcgta atgtcaatct catagagcga tgtcttttgt tgaatcaatt gatttatttt 523021 tttaacagca tctagaatat tttttgccca ctgttgattt ccagccaaaa ataaataggg 523081 caaattggtt gaaaacatat agggctgaac atagcttgaa tacagttcct gagataaaac 523141 gaaatggggt gacacattca agcaaatata cgtacaatcc gagccttcct tttcttcggc 523201 catgtgcagg tagccgctat tgataaataa tccatcccct tcgtgaacct ctattttttc 523261 ttcatttatt tgaaagagag ctatcccttt tagtatcaaa acaaattgga tttcatcatg 523321 ccaatgaagc ggaatatagc catttatatt ttgattgatc gttgtcttgt agcaggcaac 523381 tggcaattct accgttcggt gctctgttaa ttcttttaaa ttttgatcga tcacaaaatt 523441 cttcattctg acttcacacc tcaatatatt tatatttttt cattcaattt gagtattttt 523501 tatcatgttt tgcatttatt ataacactat tattatattt attagtgagg agtcatgtat 523561 gaatacttcc aatagaagaa tgggattgtt ctatgttatc acaggggcga catgttgggg 523621 gattggaggc acagtagcca aaaaactttt tcaagaatat caaattgatg tcaattggct 523681 tgtaacgaca cgcttgctta cggctggaat gttactttta atgctgcaac tgttcagaaa 523741 ggatcgttcc caggttattg aggtgtggaa acacaaagcg tcggctggcc agcttctaat 523801 ttttggccta ttgggaatgc tagctgtgca gtacacatat atggcatcca ttcaacatgg 523861 gaatgctgcc gttgctacgt tattgcaata tttatcccca gtaatcgtca ttatctacac 523921 gctgttgcga aaacaaacgg ttcttaccaa acaagatatc ataactgttg tacttgcttt 523981 agtgggttgc ttttttttgt taacaaatgg ttcaatgtct caactttcag tgccggcagc 524041 tgcagtagta tggggagttt tatcaggatt cgcggcagct ttttatactt tgtatgccgt 524101 tggtttatta aataaatttg attctcttgt cgttgtaggt tgggctatga ttattggcgg 524161 ttttgcattg ggttttatcc atccgccatg gcaactggat tttcaacgat taactgctga 524221 ggcgtatgca tatatcttat tcgtgatatt atttggaaca atgattgcgt tctggttctt 524281 cataaaaagc ttggaaagcc tctctccaaa agaaacaagc ctactaggca gtctagagcc 524341 tctatcagct gttgtaacaa ctgtcgtttg gttaaaagcg ccatttggtt cttttcaatg 524401 gattggtgct atttgtatta tagggataac tttaatattg gctttacata aagagccttc 524461 tatggagagt gaaaaatcga tattaaagat taggaatcat gcaaatcggg atatataggg 524521 gctttttttg cttacatgac cggtccggca atgaaaaaca ctggtggagt ttgagccctc 524581 tcggcagtat caaaaatacc aagggttttg acgccctagg tattttttct tcaagaacct 524641 tcaatttttc ttctctgatt gaaaaacgta ttactttttt gtgattggta tccaaatttc 524701 acttttaaaa gatggtgatg ttacatcctt atgctcgttc cacaatattt ctggaccttc 524761 tatttgttcg taatttgacg atggaaacca ttcggaataa atgcgtcccc atacttcttg 524821 cagtgtatcc ggaaatggcc cgattgattc gaatacagcc catgttgagg caggaacttc 524881 aagccgtgag aagttatctg gacaccgttt cgttgtggct gcgccaatat agtgatcgag 524941 ctctccgttt tcctctgtcc gaccttcaga aaaattcgtg gatgcactaa tgaggcctga 525001 tggtgctaca ttagatagct cttttagttt atttattgct ttttcatcta aactttccca 525061 catagatgca atttccggat taattccttt gaaaataata ggaactcttt ttttaatgcc 525121 aacgatgcga aatgcctctt tttcttcaat acggtagttc atttcatttc ctcctttaat 525181 tgttagctgg aaggtcattc gtggataagc tttaagggaa tggccattaa atctggcttt 525241 tgatgggttt atgccatgta aattttggaa tgcccgtgca aaagaatctg gtgagttata 525301 accgtacttt attgcaatat caatcacttt tacattgctg tctttcagtt caaaagctgc 525361 aagagtaaga cgtctgcgac gaatatattc cgataatgaa atacctgcaa ggaaggaaaa 525421 catcctttta aaatgatatt cagagcagaa agcaagcttt gctgcctctt gaaaatcaat 525481 atcattagtg aggttttctt caatatactt taacgcccta ttcatacttt taagcaaatc 525541 catttatttg gcctccttta accaaagaat aacaggagtg aaatgtattt atccgacatt 525601 ctgtgcacag ttttgcagga tgacttatat gaaataaagt aagtgattca cttgtatttg 525661 tacaggtttt attgaagcat gctgttcata aaaaggcatc aataaaagaa agttataatt 525721 gtcttataaa cggcacattc atataattga gtgaaaaagg atgcgtatca tgcctatcaa 525781 ttcttttgaa aattatccga tgagctggaa gccatcgatt gataaagctg aaaagcctat 525841 ttataaagca cttgcagggc aattggaaca ggatatttta aacggagttt tattacctgg 525901 aacaaaactt cctccacagc gagaattggc cgattatcta gatttaaatg tgagtacgat 525961 ttcaaaagca tttaaagtgt gtgagttaaa agggctgctg agtgcgactg tagggagcgg 526021 cacatttgta tcgtatgatg cgttgtcgaa tgcgtattta cttgaggata ctaagccgac 526081 acatttaatt gaaatgggag caatacttcc agatcacgct tcatatgagc ccttgttata 526141 ccaactgaaa aacatggttc atgaggagga ttatgaaaaa tggtttagct atggccgggc 526201 aggtgaaagc ctttggcaaa aagatgcagc tgtaaagctc atccaaagag gcggatttga 526261 aacatccgtt gatcacattt tatttgcaaa tggagggcaa aatgcgattg cagcgacatt 526321 ggcgagtctt tgtaagcctg gagatcgcat cggagttgac catcatacgt accctggatt 526381 aaaaactgtt gcatcattgc ttagtgtgca aatcgtaccg ataaaatcag aaaacgatga 526441 aatgagtccg gagtcacttg aatatgcgtg taaaaacgaa aatattaaag gtttgtattt 526501 aatcccggat tatcataatc cgacgacttc ctttatgtct gttgagaatc gaagaatggt 526561 tgcagacatt gtaaagaaat ataatctgtt tgttattgag gatgcatcgt accatcttct 526621 caacaaaaat ccgcttccgg cactcgcctc attcgcaccg caacaggtta ttcatattgc 526681 aagtttatca aaatcgttag cgccaggcct gcgtttggct tatgtagcag tgccgagaca 526741 atataaggag ccaatatcaa aggcgcttta taatttaaat ataactgttt ccccgctatt 526801 agctgaactt actgctcgca cgattgtatc aaatcaattt gaagtcttaa ttgagagtca 526861 tcgtgaacaa accattcgca gaaatcaact cgtaaaccga tatgttgcgg gatatacatg 526921 tttaggtgtt gaaacaggca tttttcgttg gttgttgtta ccgggtaaaa tgtctggtgc 526981 cgaatttgaa gaattggctg ctcgacttgg cgtgcaagtg tatgcggctg aacgctttgt 527041 agtgggaaat agttgtcctg aaagggctgt aagggtttct gtctgtgcac caaaaacact 527101 tgaagagctt gaacaaggat taatgatcct gagacgtttg ctagacgatc ttacctaata 527161 ttgtttgcca tacaattatg acattgtatg gcttttttgt gcgtgttatg atgatccaca 527221 tctagaggga ggtttataca aaattggctt ttagaaagga aggtcagatg atgttagaca 527281 aggacagcgt aaaagcaata gatgttcaaa ctgcttcatt acagagctac atcagttcac 527341 cagaaaaaca aaaatcgtta tacaagcgta cactattcgt tgtgagtatc tcacaaattt 527401 ttggcggtgc ggggctggcg gcaggagtga ctgtcggtgc gcttattgca cagcaaatgc 527461 ttggcactga tgcgtttgct ggtttgcctt ctgctttatt tactttaggg tcagcaggat 527521 ctgcattaat tgttggaaga ctttctcaac gttatggccg tcgaacaggt ctttcagctg 527581 gctttatgat tggcggactt ggagcaatag gcgttattat ggcagcaatc ataaatagta 527641 ttttcttgtt atttatttcg ttgcttattt acggtgcagg tacagccact aatttacagg 527701 cccgttatgc aggtacagac ttagcaaatc ataagcagcg agcgactgct gttagtataa 527761 ccatggtttt tactacattt ggcgcagtgg caggtccaag cttagtgaat gtgatggggg 527821 atttcgctct ttctattggt gttccatcac ttgctggccc tttcatttta gccgcagcag 527881 catatatgtt agcaggtgtg gtccttttca ttatgcttcg tccagatcca ttagttatag 527941 caagaacaat agaagcggca aatgaagagc ctggtgataa aggacatttg gcggcaactg 528001 agcatacaga aaacaaaaaa gggataatcg ttggggcaac ggttatggtt cttacccaaa 528061 tagtaatggt agctattatg acaatgacac cggttcatat gagacatcat gggcatgact 528121 tgggtgcagt cggtcttgtt attggttttc atataggtgc tatgtatctc ccttcacttg 528181 ttacaggtgt tcttgtagat aggttgggac gtaccgcaat ggctatttcc tctggaacaa 528241 cgttgctttt ggcaggtgta atagcagcat ttgctccggg agaatctatg attcttctcg 528301 tcattgctct ttctttactg ggattagggt ggaattttgg tttgataagc gggactgccc 528361 ttattgtaga ttcaactgat actgccacac gagctaaaac gcaggggaca gtggatgttc 528421 tgattgcgtt gtcaggagct gctggcggag cattatctgg aatgattgtg gcaggttcaa 528481 gttacctcgc attatcactt attggaggga ttttgtcctt attactcatt ccggtggtgg 528541 tatggtctag gggccgctaa agggtaggat tgtttaattt acattaattt gttatattgt 528601 tagataaagt atattgcagc atctaatatt ctaacgaact atagttgctc cattaaatct 528661 attataaaga tttgaccagg attccttata gctgtgtcac tcactgcata ttctttaatt 528721 gaatcacata aaatggttat cggatttgaa aaaggcagga ttactcgctt taggtaaagg 528781 agtcataacg ttgttaaaaa ggttttctct tgttattgtt acactaatga tgtctatcgt 528841 tgttgtttta gcggctgcta aagagtcgcc tggagatcat gtcatctcat ttgatgaacc 528901 tattatcttg atgatctcaa ttggaatcgt tgtattttta ttgatccctc cattagtcat 528961 gtcctttttt ggcaatttgg ttgtaagaat aatatctggt gtataccaat gttttatcgt 529021 tttcactttt ctggggctca ttccaattgg atttcttatt cccaatggct ttttgacaat 529081 tctagtttct attgcaggaa ctttagtcag tatagctagt gttgccgtaa ccttatgcat 529141 tggcaagaat aaaaaagata tataatcatc gaattgttat tttttcagat tgtcagtgaa 529201 ataattatac aaaaagagaa ggcttgtggg ccttcttttt ttgttgttgc atcatcccca 529261 ctttgagctt aatctattga ataataagag aaggaaccta tagaagaata aaataaatac 529321 cgagatgtca aaaataaaac tggacttcat tattgtgaat tcacgtaaat gtaaaaagat 529381 tggaaagagg ggaattcctt catgacaaat agcagaacaa atccgaaggt tgatgaattt 529441 ttaagtaaag cgaaaaagtg gaaggaagaa tttgagaagt tgagaaccat cattcttgac 529501 tgtgagctga ctgaagattt taagtggatg catccttgtt acacatatca taataaaaat 529561 attgttttaa tacatgggtt taaagaatat tgcgcgcttc tgttccacaa aggcgtctta 529621 ttacaggata cagatggaat tctcattcaa caaacggaga atgtacaggc ggcgcgccag 529681 attcggttta caaatgttca ggaaataaat gagctagaaa acattttgaa agcctatatt 529741 cacgaagcca ttgaagttga aaaagccggt ttgaaagtgg atgttaacaa aaatattgaa 529801 ttgaacattc ctgaagaact tcaaaataaa ttcgatgaaa tccctgcatt gaaaattgct 529861 tttgaagctt tgaccccggg acggcaaaga gcgtacactc tttatttttc tcaagccaaa 529921 caatccaaaa cccgagaatc gagagtcgaa aaatatgtgc aaaaaattct cgatggaaag 529981 ggattaaagg attaggcacg ccaaggttca ggctaaagga atagcatcat agcgtaataa 530041 gatcatttct atagaagaaa aacaagcata gtaagatgct tgttttttct taggacaaca 530101 ttcacttact gctgaaatgc ttctaacatt gtatgccact agacagcgtt ataaaatatt 530161 aatgcaacac ctagaaatct atccaatgaa atagctcaat ggtatggctc attacattta 530221 gaatgcctag gagaactaat agaaccggaa gatttttagc aagttactac actccaaact 530281 ttgtttttgt attaatatac cttattaacc attgttttta gtcaggtgca gacaaacgaa 530341 tactgattaa tgaatcatca tgatatcaat gagccgcttg attttttcat cgtcgcctgt 530401 atcaacgtac actgtttttc tgttttttat gatactctca gtcacttccc gcatgacgcc 530461 tttttctata tcatcagcgg aatcccagcg taaaggcaca ttatatacat gaattgtgcc 530521 atccccattg ccatgataag tgactgatcc atccactaaa cgagaacctg ccaactgggt 530581 cacattttct ggatagctgg cacttgtatc atcattagga ttaattggct cgccagccgc 530641 aatatgtcga acatttaatt catctatctc ttgattaggt ccaagttgaa gccaaactct 530701 ggcatattca attttttccg aagagtatgc tgccaataca ttgtcttctt tgcttttctc 530761 ttctgctgaa gaggtatcat ttgcagcttt tgttgcggat tcttctgatt ctgttattgg 530821 ctccgcttca tccttgcgta ttttggtgct ctcttcaggc tcagtgtgtt tttcgtcagt 530881 ttgcacagca gaagcttgat ttgaaggttg ttgtgcttct ccatccttac tgtccgtaca 530941 tccagcaagc aaaatcataa gcagcagggc agtattgcaa taacatatct ttctgcgttt 531001 cttcattttt tcattcctct ctattaattc aggtcagctt catatataag tttatgtatc 531061 taaatattac catggaatag ataggatgat attgaaaact gtttaagaag aggaaacgat 531121 cttgaatagc atcgcgaaaa cctaagaatc ttaagaagtt ttgccccttt ttcttcaggt 531181 attgaatgta aagtgggata taaatgcaaa caaaaacgaa atgccttatc cacctcgtgt 531241 catggcagaa aaagtggggg atttattaga gcggatttga taatggcggc aggtaaatgg 531301 gtgttgactt atatgtctaa gcgggagact caagtctgct cgatcgcata caaaatacca 531361 agggccagca acccttggta tttttatacc ttcatgcatt tttgaagttt atgcttaaag 531421 gtctgcctta ctttgcaaat cgccgagctg ctgcaacgca catgataacg gcgatattca 531481 ctgctacgag tgcccagccc actttctcgt gcagaatcac tgaggcaagc agcagtccaa 531541 aaaaaggctg gagaagctgg agctgcccaa ccgctgcaat tcccccttgg gcaagacctc 531601 gataccagaa cacgaagcca atcagcatgc tgaataagga tacatatgca agactgagca 531661 gtgcgggaac gccgatcgcc gaccatgagt ccggcgtaaa aaagaacgac aatggcagca 531721 taagaggaag cgacagaacg agtgcccatg agatcacctg ccaattcccc agacgccgtg 531781 aaagtttggc cccttctgca taaccaagac cgcatacgac aatagaagcc agcatgtacg 531841 cgtcgccaag cggggatgaa cctcccccct gaatgagggc gaaacctgct actaacaagc 531901 tgccggcagc tgagaaaatc cagaagacgg ggcgagggcg ttcacccccg cgcagtacgc 531961 cgaagactgc cgttgcgagt ggaagaagtc caatgaagac aatggcgtgt gcggatgtga 532021 catgctgaag cgctaaagct gtcagcaacg ggaaaccaat cactacgccg aacgctacca 532081 ctaacaatga aatgagatct cttttggcag gatgctgctg ccggaagatg agaaggagac 532141 ctcccgccag tacaccagct atcgcagcac ggcaaactgt gagaaataac ggatcgaagt 532201 ctgacacagc caaacgggtc gcaggcagcg agccgctgaa aatgagtacg cctataaaac 532261 catttatcca gccatttgtt gttttgttca ttataatcac tccacatatc tttcttgttc 532321 attgtctgta ttttcttaac aaaaccagca gctaaggatt acaatgacta taaactggaa 532381 ttggcctttt ataaacagcc agttttcata aaaaaatgca taccagttag gagaacaacg 532441 cgcaaatgga tatcacgcct tttttgaata gaactctgga tattccgctt tatcagcagc 532501 tttatcggta ttttaaagaa aatatgcatc ggggccgtat tcaaaaagga atgaagcttc 532561 cttcaaaaag actcctggcg aatcagcttt ccatcagcca aacgactgta gaacgtgcct 532621 atgaacagct cgctgctgaa ggttatattg tgagcaagcc aagaagcggg tggtttgctg 532681 attatcatga ttctgatttt gcttatgata gaatgccaag cacaacaccc attcaacaag 532741 aagcagaaga aaataaacaa tggattgatt ttcattatgg gaatgtagat tcttcttact 532801 tccctttttc cgcatggcga aaaagcatgg tcaatagctt agaccaatat ggacacgagc 532861 tttatcggcc gggacatgtt ttaggagagt ttgagctgag aacactcatt gcagagtacc 532921 tgtatcaatc tcggggggtt cattgcggcc ctgaacaagt gattataggt gccgggaacc 532981 ctattctgct gcaaatcttg tgccaagttt ttgagccgaa tatttctata gggtatgagg 533041 atcctggtta tccaagagca cgcaagattt ttgaagccaa ccgcatgaat attgttccta 533101 taccagtcga tgatgaggga atctgtatac agaagatcaa agaacagcag ccaaaccttg 533161 tatatgtcac accttcccat caatttacgc tgggaaccat aatgacaata aacagaagaa 533221 ttcagctgct caaatgggcg gccgaaaatc aatcctttat catagaggat gattatgacg 533281 gggaatttag gtacacagga cagccggttc cttctctgca agggcttgat cagcataacc 533341 gtgtcattta tatgggcact ttttctaagt ctcttttgcc ctcgctgcgt atcagctata 533401 tgattcttcc ttcgcctctt ttaaaaaagg gtcatgaaat cacgtcctta tataagcaga 533461 cagtgtcctg ccacagtcag ctaaccctag ctgaatttat aaaaaatgga gagtggcaaa 533521 aacacatcaa cagaatgaga aaactttacc gcaaaaaaag agccattgta ttagaggcag 533581 tgcaaaggga attaggagag catgtcagaa tccgcggaga aaactctggg cttcgtatct 533641 tacttgacgt ttatttgcca tttggtgaaa aagagttaat tgagaaggcg aaaaaacatg 533701 gagtaaaaat ttatcctgtt tctctttctt atcaacatca tcctcctaca aaaacggtct 533761 cgctcgggtt tgcaggggtt tctgaatccg acataagaga aggcataaaa aaactgaagg 533821 ctgcctggaa gatatgaggg agctttcagt ttagcaaaac ggccaagtga cgactaagtg 533881 ttgagagctg ttcaatattt tttaagtata tgatgagtgc ctgcagtcca ggccacgata 533941 cgtctgttta gcgaaaaaca gaatttttta tttgctcctc acagtgctaa aataaacaaa 534001 atagacaatt gaaaaaatag aggtgtaaga atgaagttag atgagtttac aattggccag 534061 gtcttcaaaa cgaaatcatt aaaagtatca aaagatgata ttatgcggtt tgcgggtgaa 534121 tttgaccctc agtatatgca tgtagatgaa gaaaaagcga gtaaaggcag atttaatgga 534181 attatcgctt ccggcataca aacactggcc atatctttta aactttggat tgaagaaggt 534241 ttctatggag acgatattat agccggaaca gagatgaatc atatgacatt cataaaaccc 534301 gtatatccgg atgatgaatt gtttacaatt gttgaggttc ttgataagca gccaaagaga 534361 aatgaattgg gaatactcac agtattgcta tctacttata atcaaaaaga agtaaaagtg 534421 tttgaaggtg agttatctgt attgatcaaa cgataactca gaaagcccgc ttttcgcggg 534481 ctcgattgaa gcagatgggt gaaagatgtt agcgggtttc ctttgaaaaa taagaggtta 534541 aaacatcata aacaataggc aaagaagtaa atccctcatc ttctagaaaa tgacctccgt 534601 gctgaacttc atataacgca gcatcaattt gttgtgccag atccttgctg aatgaaaaag 534661 gcacaatttg gtcgtcctta gaagcaatga cagcacggtg cttcgcggac tcgatgattt 534721 tttgatgatc aaacgatccc tgtgtaaatt catctaacat ctgtaaagtg ggcaatgatt 534781 tggcaaagcc ggaaacaagt atgattccgc caagctgttt tcgtaattga agatgttcca 534841 aaaatctcaa aatggcgggg caacctaagc tgtgcgcaac caaatacgta ttttcatgta 534901 aagtgtgctg atataaagag agtgtatcca gccaatcctc aagtcttggc tggagcggat 534961 taggcatgtt taaaatgtct gcttggaccc catctgcgag cagacgtttt ttcagccaag 535021 ggaaccaatg atttgttgag gaggctctgt agccatgaat gatatagact tgttttgtca 535081 ttatttcctc ctaagaaata ttttcattca gtataaaatt cctctcattg ggaaacaagt 535141 acgcactttt ttgtaagtag ctttacatat gaggccctcc ttgtgccatt ccccacttac 535201 acatctcatc tatgagggga tacaaagatc gccctctgtc agataacgaa tactctactt 535261 tcagtggggt gtgagaaacc tcagaccgat gaataaggcc gtcagtttgc aattccttaa 535321 gctgtgcgct taacatttta tgggtgatga agggcatagc ccttttcagc tcgccgtatc 535381 tcatcgtttt ttcacaccct aactcataga gaattctcat tttccatttg ccccctataa 535441 gagataaggt gtattcaaat ggggcttgtt tactgcggca caggctattc attgtaatca 535501 aacctccttt tttaagtatc atatcagaat aaattaggat tttcggtgtt gaagtttgag 535561 ggcgattcac gatctgaagt gaaaggggcc gcttgctcaa caggcggcac ggtacatgaa 535621 tgttctaagt caaagagggt taccttactg ttagttactt tatttaaaaa aacgcatgtt 535681 tttagctgaa aatatctatt atggtatatt taaatataaa gaaatatttg agaaatgagg 535741 aatggtatga atacacccaa aaaacataag aaatttaaag cgaaaatgat tctccaaatc 535801 atcatggtta tcattggagg aatcatagcg gcatatggac tagaaacagt gctcattcca 535861 aacagtgtat ctgatggagg ggtgacgggt cttagcatcg ttggttcaca gctattcaac 535921 ttgccgctgg ggattttgat tgctgtgatc aacattccat ttgtctggtt aggatataag 535981 caaattggga aaagctttgc attattatca attatcggaa tcgtatcgct tgccgcgggg 536041 acaagctttt tccaccacac acccgctatc atagaaggag ataccctgtt aattaccgtt 536101 gtcggcggga ttatccttgg attcggaatg gggctggcgc tgcgtaatgg cggcgcatta 536161 gatggaattg acatgcttgc tgtgctgcta tcccgaaaac tgccattcgg aacgagcgat 536221 ctcattctat tcttaaacct atttgtgttt atttttgttt ccacagtatt tggcttacaa 536281 ggggcattgc tttcagtcat tgcttactac attgcatcca aagtgattca tgttgtggag 536341 gaaggcttaa gcggctctaa aacctttcaa attattacaa cccaacctga attaatggta 536401 gagacaatac gtgatcaatt aggccgaagc gccacatata aagaagctta cgggggtttt 536461 tcccacgaga aatttaaaga aatcacatgt gtcatcaacc gtttagaaga aaccaaacta 536521 aaggaaatta ttaatgatat tgataaaact gcctttgtta ccgtgtatga tgtagctgaa 536581 gtgaagggca gcaattttag aaatcttaat catcactaaa aaatagaatg acctttttaa 536641 ccgtaactga catgccgcgg gtaatttaat caaaaacact tttttgaggc ttgtgggtga 536701 ataaccggtg aaggtctgaa tcacagaaat accaagggcg tcaaaaccct tggtattttt 536761 tctggttatt agattttatc ttcagcttta cgtgctgctt cgagcttatc aatcctgtct 536821 ttatattttt ctccccagtc cttcatgtgc aggataacag gttctaatgt tcttccaaac 536881 tcagttaaag agtattcgac ttttggaggg acctgtttat aaacctcgcg gtgaatcacg 536941 ccatcccgtt ccaattctct taattgtagc gtgagcatac gctgggtaat ttttgggtat 537001 agttttcgaa actcattaaa cctcttttta ccgtcaatga gatgataaag aagaatgcct 537061 ttccacttac ctccgatgat atctaatgtt gtctccaccg gacatccttc aaagtcatca 537121 gaagaataat caatgccgag tttacgattt ctcaagctgt tcactcctaa tagtatactt 537181 tttgatacta tatacattca atgtgcgtac tttttatatt ttaatataca tcatataatg 537241 atgtcacatc taaggaatga aaggaatgga tcatatgaaa acactcgtac tcgttgtaca 537301 tccgaatata gaatcctctc gtatcaataa aaagtggaaa gaagccgttt taagtgaacc 537361 agatgtaact gtccatgatc tttatgaaaa atatcgcgat caaccaattg atgtggaatt 537421 tgaacaacag cagctcctgg cccatgaccg tatcgttttt cagtttccat tatactggta 537481 cagcagccca ccgcttttaa aacagtggtt tgatgaagtg tttacgtttg gctgggctca 537541 tggtcccggc ggaaataaat tgaaggggaa agagtgggta actgccatgt ccatcggttc 537601 acctgaacac tcttatcaag ccggcggata taacttgttt tcgataagcg agctgacaaa 537661 accgttccaa gcatctgccc atttagtagg catgacctat ctgccttcct ttgccgaata 537721 tcgcgccaat acaatcagtg accaagaaat tgccgaaagt gcgaatcggt atgtaaagca 537781 tattacaaat atagaattaa acccgaaggt tcgcctgcaa aggtatttga aacagctgga 537841 gagtgtcgat ttaacataaa gattgatttt tgaaaatcct gtactcacca agcaggattt 537901 tttcttgttc agcagaggga ttttaacata tagcaaaaaa agaagaagcc accaaaaata 537961 agctatttgc ttggtcctga ctgcttattt ttggtgaaat acttatttct ctgtgatgaa 538021 ataaagcaaa gcgatgaccg gaaaagcgat tccaatccat aatgctgtac tccatccgcc 538081 tgaggcatat gcccatcctc caattgatga ccctatcgca ccgcctagaa agaagatcgc 538141 catgaataat ccgtttaatc gactgcgaat ttcaggcgcc aacgaaaaaa tagcacgttg 538201 actgagcaca aggtttgcag atacacccat atctaacaga atagcagcgg ccactagaac 538261 tgttataccg acgggggagc tgctctgaat catgagcggc agtaataaag agacaacgac 538321 aacaccgaga gcgattccag tggcaagcct ggttaagcct cgatcagcca ggcggccgcc 538381 tattggtgca gtgactgcac ccgcaatgcc caccaatgcg tagagtgcta ttgccttctg 538441 agaaaaatga aaatcaggac cggacaataa taaaggaaca gttgtccaga acaagctgaa 538501 agctccaaat acaaacgcat gatagatggc acggcggcgt aagactggag tcgtgcgcag 538561 cagcttccac attgaaccga gtaaggcagt atagtttgta tttgctgttg gttttctggc 538621 aggaagcact tttgataata cgatggccag gataacactt accacggcgg acaaagcgaa 538681 tattgcattc cacccccaga tatcagcgac tagactagat atcggacggg aaagcataat 538741 accgagtaat aagccgctca tgacattgcc aacaacccgg ccgcgtgcag cgtctgatgc 538801 aaggtatgat gcaaatggaa caagcacttg ggctgcgatt gatcccaatc cgacgaaaaa 538861 cgcagctgct aaaaacagtg ttccatgctt cacaaatgct gttagtgtca aagccgctgc 538921 gcttagaagg agcgatacaa caataagttt tttgttttcg ataatatctc ctaaagggac 538981 aaggaatagt aagccggcaa cgtatccgat ttgggtgagt gtgacaatca atccagcacc 539041 gcttggagaa agtccaattg ccttactaat taatccgacc aagggttgtg catagtaaag 539101 attagcaaca atgataccgc atgcagttgc gagaagaagg gttaaactgg gtgaaatcct 539161 ctgacctgct tgtttgtttc cattagccat atgaatgaac tcctttttaa gtggtttttt 539221 gagtgtaatc atgacttctc acaagtgatt ttataaactg aacgttcagt ttcgtcgatt 539281 aataaaaata atatactaaa cgttcagttt tgtaaatgga tttctgtttt ctttttttat 539341 tcaatttaag tatactgaac gtatagttta tattgcggga aggaatgatt tatgtgcaga 539401 gtaaacgagg gcggccgcgt gatgaaggaa cgcataaggc gattctctct gcagcctatg 539461 acctattgct ggaaaaaggc ttcgatgcgg tgacagtcga taaaattgcc gagcgtgcga 539521 aagtgagtaa agcaacgatt tataaatggt ggtctaacaa ggctgccgtt atcatggaca 539581 gctttctttc gaccgcgacg gacaggctgc ctgtgcctga tacagggtcg tcagtacaag 539641 atatagtaac ccacgccacg aatttagcta ggtttttgac aagccgggaa ggaaccgtta 539701 ttaaggaatt aataggtgca gggcagttgg atgaaaaatt ggcagaagaa tatcgcacgc 539761 gatttttcca gcctcgccgc ctccaagcga aaggccttct agaaaaggga attcagaaag 539821 gtgaattgag agagaatctt gatattgaag taagcataga tctcatttac ggaccaattt 539881 tctatcgtct gcttataaca ggggatgagg tgaatgattc ctatgtgcgt gatttggtga 539941 tgaatgcgtt taagggagtt caagctacct ctgctacaga gagtatgtag ctgataagaa 540001 ctgcaaaagc tgcggattat atgacaaatt ggttccatcg tacagtgaaa tataagattt 540061 ttgttgctga gcggaatcat cgagggaaaa gttctcttat cggatgtcga aaaagaagtc 540121 attcaatcgt gaatacataa catcatatta ttacattcct tttcatcgat tggaacaagg 540181 gttctatact tcaatggaat accgcaaagt tggagtattt aaacaacagg ggaaaatcga 540241 tggccattat gtaggtgtca tggcaatgga aaaaatactt gcaatgtaaa caggcctcta 540301 aagagacctg ttttttaata tccagatgat tgtctagttt cagcttgggc tctatgacca 540361 ctcccataac tgaaatagtc taatatttat accagaaggg attgtttata taaataaaag 540421 tttatataat gacgggggcg ctaaggaaac gcggggagcg actcaggttt tcgtttcaaa 540481 gttttgatcc ttaagatata cggagcgcta catatggaaa cgtaaagggg aatgtataat 540541 catttggcgt gtatataacg atttgcttat atattgattt gggaaggagg agctcatatg 540601 acgattgatg ttgcggcgat gactcgttgt ttgaaaacac ttagtgatca aactaggctt 540661 atcatgatga gattatttct tgaacaagaa tattgtgtct gtcaattggt tgatatgttc 540721 gaaatgagcc agcccgccat aagccagcat ttgcggaaat taaaaaacgc aggttttgtg 540781 aatgaggaca gaagaggcca atggcgttat tattcaataa atggttcctg tcctgagttt 540841 gatacattgc aattgatctt acatcaaatt gatcaagagg atgaattgtt aaaccatatc 540901 aaacaaaaga aaactcaagc gtgttgccag taaggaggca ttagattgac atcaatgatt 540961 ttggcagtat tcatcttttt attaactcta gtattggtca tatggcagcc gaaaaattta 541021 tctatagggt ggtcagcctg tggaggcgca gttttagctc taatagcagg tgttgtcaat 541081 tttcatgatg tgttaactgt gacagggatt gtttggaatg cgaccttggc ttttgtggcc 541141 atcatactga tatcgttaat tcttgataat atcggtttct ttgaatgggc agcgcttcat 541201 atggctaagg ctgcaaaagg atacggtgtg cggatgttcg tttatgtatc tctattagga 541261 gctatcgtcg ccgcgttatt tgcaaatgac ggtgcagctc ttatattgac accaatcgta 541321 ttagcgatgg tcagagcatt acattttaat gaaaaattag tttttccttt tatcattgcc 541381 agcggattta ttgcggatac cacttcgctt ccttttgtag taagcaattt ggtcaacatt 541441 gtttcagcgg actattttca tattacgttt attgattatg catccagaat ggttgtcccg 541501 tacctgtttt cgctgctggc gagcatcatt gtactttacc ttttctttag aaaaagcata 541561 ccaaaacgct atgatctgac tgaggttaaa aaacctgttg aagcaattaa agatcaaaac 541621 atgttcagac tgtcatggta tatcttaggg ctgctgttaa ttggatattt tgcaagtgaa 541681 tttttttcta tccctgtatc agtggtagcg ggcagcattg caatcatttt cttaatcgct 541741 gcgcaaaaga gtccggccgt ccatacaaag aaagtggtga aagaggcgcc atgggctatc 541801 gtattctttt caattggcat gtacgttgtt gtgtatggtg tccgaaatgc cggattaacg 541861 gatgtccttt cagatgtgat tcaagccgca gctgatcaag gattgtttgc tgggacaatt 541921 ggaatgggct ttattgcggc gattctttct tccattatga ataacttgcc gactgttatg 541981 attgacgcat tggccattgc cggtacagat acacatggga tgatgagaga agcgcttatt 542041 tatgcaaatg tgatcggttc agatttaggg cctaaaataa caccgattgg ttccttagcg 542101 acattattat ggcttcatgt tctttcgcac aaaggtatga agatttcctg gggcacgtat 542161 tttaaaacag gaattatcct cacgataccc actttattga tcacacttgt cggcctgtat 542221 atttggctgc tgataatcca ttcttgtttc taaaaggaca aggtcactat atcaaggaaa 542281 acaatgcact ggtaactctt gccgcagcca aatggctgaa gggtggggga gaaaatacct 542341 tggggctaag tggaatgtgt acagcgcagg aatcgaagct caaggatgac atcgagtgct 542401 gtcaaagcaa tgaaagaagc agggattgat atttcaaatc aaacatcgga gaaatttgat 542461 gatccggcaa aagcacacgg aacagaagaa gtgtttccaa agggtccgtg atgaaattgg 542521 tgaccgttta aaacagtttg ctgtaactgg ggaataaaga atcgatatat tcagcgtttt 542581 cttgggttat ataatacaat gtgttgttca acaggtgtct gcgagctgag tgcagacacc 542641 tgtttttgtt tttatttgtc tgagattcgt aacagggaag ttatttagct ggtgacagag 542701 gaaaattgat ttgtgaacag aatcatgaag gagacggtgt tttaaaggag ttgtctgttt 542761 tgcaggaatt aacaaaaaaa aaatacagta gcttaaaaac aatgtttgat gacaaatatt 542821 gtcccacatt tgtctattca atattagacc aaaccattcc gggagctgtt tatgcagatg 542881 atcaaacctt tcctaaatcg ttttttatag gaactgaatc aggcatttat tttattgcgg 542941 gagaccaagg gaatcgggat tttcatgatt tcattgcagg atattatgaa gaacaagtga 543001 aatcatcaaa acgatttacc ttgttttctt ccagtgatac atgggatagc gtactgaaac 543061 ccatactgaa agatgactta aaccaaatga gaagagctgc attttcttat caaccaaaat 543121 ctttcaaaaa gactttgcaa ctgccaaagg ggcttgtatt gaaaagaatt gacgaagaca 543181 tcatttcaca tagcacagcg tttaacagcg cgtattatga ggagtattgg aattctgtct 543241 cacagtttgc ttcaaaaggt tttggatttg ccgtattaca tggcaatcac gtagtaagtg 543301 agtgtacctc tatattttta gggcataatc gagcggaaat ggatatctat acacttgaag 543361 aatatagagg actggggtta gcttattgcg tagcaaatag gtttatagcg ttttgtatgg 543421 aaaatgggat tgttcctagc tgggattgtg atatttgcaa caattcgtcc attgcattag 543481 cagctaaact agggtttaag acggtaacgg aatacactat ttactactct ggctaacctt 543541 aatgaaagaa ccttaaaagg agataccaac cgatgttggt atcttttttg ttttagagtt 543601 tttttaccct tttagcagaa aaatgggtga tgaaaatctt attcatttta tttactttta 543661 ggtaggtaaa acataccccg ccaactgtaa ccactccgcc tagcagagag agcagtgtgg 543721 gtatctcgcc gatccagagc caagatatga tcaaggctaa agccggtgta acataaagtg 543781 aaagggttgc ttctgaagca ccgacgaatg aagtgacata tgctagtgcg aagtaaggaa 543841 taaccgtcgg caataatcct aagtaaacga tagacaaagt tgcgcttatt gaagcgttca 543901 tcatctcttc gcctaagcct ggcagaaaca caagcatagg tattgttccg ccccaaatgg 543961 tgaatgtaac gaatggaata aaaccatatt tttttatata gcgggcttga aaaacgaaat 544021 aaatactctc cgaaaatgct gccagcagga tgaccaagat accgctcatt gaatatgtaa 544081 agtctcccgc cccaaatgca atcaataata cacccaataa actgatcata gagccaagcc 544141 atttcgtaaa tccaaaatgc tctttataaa acaggcggga tagcatggct gagaagatcg 544201 gtgccgtagt aacgagtaag cttgcaactc cggcactaac tgttttttca ccgatgttca 544261 gcaaaatgtg atagaatgca aatcctaaaa accctaaaag aaaaatggca ggaatgtctt 544321 tcaagtcggg taggcgcatc tgagtcaaaa cagcaaaaag caataatgcc atagagccga 544381 ttaacaaacg aaataaagca aggtgttctg gcgtgtaccc ttcaagtcct gcgcgaattc 544441 ccggaaaagc agatgcccat aaaccaatca tgagactatg agatatcatt atttgaactg 544501 ttttctttcg cattcctctc actcctcttt acaaaaacca accagttatt taatgtgttt 544561 ctatactaat aaagatttga tgatatggct tcaaccagtt caatagattt tgacccaacc 544621 aatttatttt aaggagaccg attctatgag ctttccagaa gaaaaaaaga tgaaaaagct 544681 ccctaagtac agacaaatcg ttcattttat taaagagaaa ataggaaatg gagagtggcc 544741 gattggaagc aagattccaa gccagcgcac gcttgcaaaa gattttcagg taaatcggag 544801 cacagtgatt acagcgttag aggaattgat ggccgatggg ctaatagaag gcacaatggg 544861 gaaaggcaca gttgttatca acaacacatg gacactgatg gctaagaatt ctgctcccga 544921 ttgggatcaa tatgtcacct ctggcattca gatgccaagc cgaaaaatcg ttcaagagat 544981 aaatcaatca gaatcaaata cagaccttat acagctcagt aaaggtgaac tttcagctga 545041 gatttttcct ttggctgtta tgaaagagat gatggggaag gtatctcaac acatggaggc 545101 attcggatat gaagaaccaa aaggttactt acctttgagg gaggcattaa gcaactattt 545161 aaaaaccatt ggaatcaacg tctcatcttc ttccattctg attgtctcag gagcgttgca 545221 agccttgcag ctgatatcaa tggggctgtt acaaagagga tcaaccgttt atcttgatca 545281 gccctcctac ctttattcat tacacgtatt tcaatcagct ggtatgaagc tgactggact 545341 tcctatggat aatgaaggac ttttgcctga aaatgttcat ttaacaagag gagagcgggg 545401 aagggctatc ttatatacaa atccatgttt tcacaatccg actggtattc ttatgtctaa 545461 aaagcgacgg gaagaaatcc tagcagtaag tgagaataca cagcttccta ttattgaaga 545521 tgacatttat cgtgagttat ggatcgatga aattccgcca tatcctatta aaacaattga 545581 taaaaatgga cacgtactgt acataggaag tttatcgaaa acattaagcc caggtttgag 545641 gattggatgg atcgtcggac cggaaccggt gattgaacgt ttatctgaca ttaaaatgca 545701 aacagattac ggatccagtt cgctatccca gagagtagcg gcagagtggt ttacttccgg 545761 ccactaccag cagcatgtag aaaaggttag gcagcaatta aaggtgagaa gagaattggc 545821 cttgagtgct ttagaaactc atttgaaaga agtggcgaca tggaatatcc caaaaggagg 545881 gttttttgtc tggataaaaa tattgccttc catatcaatg aaattacttt atactaaagc 545941 cttatcaaaa gggattctga tcaatctcgg cagtatctat gctcaggaaa aagggaatta 546001 tattcgctta tcatatgctt atgcatctct tgaagacctt caaaagggga tttatgagtt 546061 gggtttaatg attaaagaat tggcaagcag gtaactttta tatccttaaa tggatgtttc 546121 actaaaaaag agatcaagcc taatgatcgc ttgatctgat aataacaagg gttactagaa 546181 tagaccaaat catggttcgg tcttaaaata atcatgtctc tgaacgaaaa gtctttccga 546241 cttctcttcc taaaccaaag tagtgtctga aattatagat aagcgggctc catttggaag 546301 ggttgatatg gttttcgtcc agaatgatac tttcctcggc atgaaaatgt agtgcctgcg 546361 tctctacaat tgcgaatgac gattcatatt ctggaagccg aatgtgtttc acttcggctt 546421 cgatttggat agggcattct ttaattcgtg ttggtgatac tgtttttgat tgtaaaggcg 546481 ttaaccctgc tgcctcgtat ttttcttttt tatatgtaaa tccgatctgc ttctttaaag 546541 gcggtatact cttttttccg ctataagatg aaattctttc aacgttttcc cataaatccg 546601 ggccaggcaa gtttatgaca cactctttgt gtctttccaa attgtcgatg gcttttcctc 546661 ccagtcctac tccaaggatt atataatgtc caagagccca agaagaagac ataggactaa 546721 tattagtggt tccatcctca ttcaatgtgg ttagaagaaa tgtcgaggta ccataataca 546781 tgatcttggg tttgatttcc ttaaatcgac gagtgtcttg ttttttgatg tccaacgttt 546841 tttcctcctt gtcacgctta catttatatt gtaaaggatt aacatttcaa ctatcatcga 546901 aatatgaatg taaggaggaa aatcatgaat cctaatattg caaaaatctc ttcgttgcta 546961 tcagatccct cgcgttcttc cattcttctc agtctgatgg atggaaggat acaccctgcg 547021 ggagagcttg catatctcgc taacattaaa cctcaaactg caagttttca cctgaataaa 547081 ttgcttgaag caaagctgat tagcgtagag aagcatggga gacatcggta ttacagattg 547141 gctgactcag atgctgcaaa tgtgatcgaa caattgcttc atattgcgcc taaagcaaaa 547201 gtcaaatctt taaaagagtc aaaagagaaa aaggacttgc atttcgcccg gacctgttat 547261 gatcatttgg caggttatgt gggcgtgcaa atggcacatt cactagttga gcaggggatg 547321 ttaaaaaaag ttgatttaaa ctttgaggtg acttcagagg gtgctttatt cttttcgaag 547381 ttaggcatca atgaagagca acaacggaat aagaggagag cctttgcccg ctgctgtttg 547441 gattggagtg aacggcagca tcatattgca ggagcattag gaaacgccct attggtgcgc 547501 atgttagaag aagaatggat cgttcgtatg cctaaaacga gagcgattag gattacacaa 547561 agcgggaaaa tcgcgtttga aaagcaccta aacgtgaaga tttaggattt tgaagcggaa 547621 acatcagatg atgaggcacg atatctagga ggagtaagat ttgttctaat cttactcctt 547681 cttcttattt tgaagcagct cgattcccca ttgcaataga gatgcggttc caactgttta 547741 tttgattaat gatcagaaca aggtcaacat attgttcctc atcataatgt tcccgcaccc 547801 gatgatatag ctcatcagga acccttttag atggaatgag cgtgatgtgt tcagatagtt 547861 cgagagccgc tttctcttca ggtgagtaaa aatcacattc attccaagca tgtaaacagt 547921 aaattcgctg ttcagtttct cccattttgc gggcatcgga cgtatgcata tctatgcaga 547981 aggcacagcc gttcatttga gagactctga ttttgattag ttctctcgtc gttcggttaa 548041 ttgaggattg tttcgtgtat ttctccatat ccatcatgat tttcatacct tcaggtgcaa 548101 tctcatagta ggacactctt tgactcataa agcaagactc ctttccatag aatacctaga 548161 ttgtatcccg gtattgatca ttttaccaat gtgcggtttg aatgacagct gtttcagcgt 548221 cttttggaaa gaagcttctt tgaataaaaa taagggtagc cagcaatgat gagtggagct 548281 gctaatgcaa gcagtatcca tgagcctgat tggctgtctc tagtgactct aatgaatata 548341 taagtaccga tcagaaaata taataaagca cctagaaacc aatacatgtt cattcctctt 548401 tttccttgct ttttggttgc gcatttttgt ctgtcatatg gcttaatcga tcagggttct 548461 gattttttaa taccttttcg gtccggattc cttttctctt taatgataaa attgtgagat 548521 caatcgattt caatgatgat cattccttca atgaatagta agttccttat gattttaaag 548581 gtaaatttga aaagataaaa cgtacataga ggcagaacgt tcatgtacgt ttgggcaatg 548641 atcacttgtt ggaaactcta atgtttccct gcacctgata ttgttgtgtt ccttctcttc 548701 ctataaaatg attggataca tgtatgtttg cacgttgaaa tatgggttcg attttcatga 548761 atctctattc ggtgaaacag gtaaaggaag tggataaggt ttgcttataa ggaatccttt 548821 taaagataaa tattactcac atgataggcg ggcattaaac atgcttgcac tcagagtgcc 548881 gggcctggct tttattctca tgatctatat agcctctatc gtgctgcaat ttgtttctgg 548941 gggctggtcc attttattgc tttatgcgtt taccatatta atcgccattt ttgctttgct 549001 tcattggcac tcatatcgct gggttaagaa aagagtgatt ctgtatttcg cggtacaagg 549061 tttgatcacc tttgcacttg ctaatctcat gactggcttc tttatacttg tgattatcgg 549121 cctttatgca tttttaattg gacaaattat aggaatggca gacagaagaa ggacttttct 549181 cattctttat ctattgctgc tgctggtcat aaattcggcg tatcaccttc ataaaggtga 549241 agttttgcat tttattgtta ttgctgcgcc gatcatgatt gtcatcatca cttatgccgc 549301 aacatttttt gcccaagtcg atgaaaaaat aaaagctcaa ttgactcttg aaaggctgga 549361 gctggctcat cagcaggtag aacagctgac gctgcagaac gaaagacagc ggatggcccg 549421 agacttacac gatacgcttg ctcaaggtct tgtcagttta aatatgcagc tggatgcgat 549481 tcatgttcat ctcgccaaag gcaacacaga gagagcgaag gaaatcatac aacaatcgat 549541 gaaaagagtg aaaagcacaa tagctgatgc acgttcagct attgacgatc tccgcagcaa 549601 atcagaagaa atcggtgttt taaaagaaag aattacctcg ctaatggatc attttataga 549661 gtcgacaggc atggcttgtt tattagatta cagattgcat caggtgctgg atgtgcgtac 549721 agctgaaaac tgttattaca tcattggaga atgcatgacg aatgcggcaa agcatgctga 549781 ggcgaaaaca atctggatat ccatttggga tgatgaaaag ggaaggctcc atttaacagt 549841 taaggataac ggcaagggat ttgatgttga aaaaggaaag aaaaagagag gacattatgg 549901 gcttcttggc atacaagaac gcgtcagggc aataaatggc caattcaata tcaagagtac 549961 aaaattgaaa ggaacacaaa ttgagatcac tgtaccaatt cagggagaga tgcaagatga 550021 ataaggtttt aatcgttgat gaccatcttg tcgtgaggga aggtctgaag cttttaattg 550081 aaacgaatga tcaatacacc attataggag aggcggaaaa tggaaaagta gcagtccgtc 550141 ttgcagatga attagaaccg gatatcattc tgatggattt gtatatgccg gagatgagcg 550201 ggttagaggc cattaaacaa ataaaagaaa aacacgatac ccccatcatt attttgacta 550261 catataatga agatcactta atgatcgaag ggattgaatt aggagcgaaa ggatatctgt 550321 taaaagatac gagttcagaa accctttttc acacaatgga tgcagccatc agaggaaatg 550381 tgctattgca gcctgatatc cttaaacgtc tgcaagaaat ccaatttgag cggatgaaaa 550441 agcagcgcaa tgagacgcag ctgacagaaa aggaagtcat tgttctaaaa gcaattgcta 550501 aaggtcttaa aagcaaagcg attgcctttg atttgggcgt ctctgagcga acagtaaagt 550561 ccagattaac gtccatttac aataaattag gcgcgaattc aagaactgag gcagtaacga 550621 ttgccatgca aaaaggtatt ctgacaatag acaactaaac tgcatatttg aaaattgccc 550681 aaacgtacat gcccgaatgt acgttttttt catttcattg tcaactacaa tgagaaagaa 550741 tgtgatcaag caatgtgttg aaaggagatt atcatgtcaa aaatgttata tacattagga 550801 ggatgggttg ctcgcaatcg cataaaagca atatgtgcgt ggatcgttgt gttagttgct 550861 gcgataggcc ttgcagtgac cttgaaacca agtttttctg aggatatgtc catacctgac 550921 acaccttcgg aaaaagcgat ggatgtgatt caaaaagaat ttcctcatgg tcctgataaa 550981 gggagcatac gggttatttt cggtgctggt gatggggaga aacttactgg gaagccagca 551041 aaaaaagcaa tagaagatac gttcaaagaa atcagtaaag atgattctgt tgactcgatt 551101 gcaagtcctt ttgtgacagg gacaatcgcg aaagatggca cagttgccta tgctgatatc 551161 cagtataaat catcagcaga tgatataaag gattactcta tcaaacactt aaaagacagt 551221 ttgaaaatgg ctgatgatga aggattgcaa actgagctaa gcggagatgt accgggagcg 551281 gagatggaga taggcggtgt ctctgaaatt gtcggcatta tcttggcttt tgtcgtttta 551341 gccattacat tcggttcttt attaatagca ggtttgccga ttttaactgc actgattggt 551401 ttaggtgtaa gtattggact ggttttgatt gggacacaag tatttgatat tgcttctgtc 551461 agtctttcat tagccggaat gattggcctt gctgttggta ttgattatgc tttatttatt 551521 tttacgaaac accgccagtt tttaggcgaa ggcatacaaa agaatgaatc aattgcgaga 551581 gccgtgggaa cagcgggaag tgcagtggtt tttgccggac ttactgttat cgttgcactt 551641 tgcggattaa ctgtcgttaa cattcctttt atgtctgcga tggggctgac agcagggctt 551701 agtgtactga tggctgtttt ggcttccatc acacttgtgc ctgcggtctt atcgattgca 551761 gggaagcgga tgattccgaa atcaaacaag aaaatagaaa aacaaagcac tgaaacaaat 551821 gtctggggac gctttgtcac caaaaatcct atcatgctaa gtgtatgcag cattctgatt 551881 ttgatcgtca ttagtatccc atctatgcat ttggaactgg gcttgcctga tgctgggatg 551941 aaagctaagg ataatccgga tcgccgggca tatgacttgc ttgccgaagg ctttggagaa 552001 ggatttaatg gccaattaac aatcgtagcg gatgccacaa atgctacaga aaataaggcg 552061 gaggctttcg cagatgcagt gaaagaaata aagggcttag accatgtagc aagtgtcact 552121 cctgcaatgc ctaataaaga agggaacttt gccatcatta cggtcgttcc tgaaacaggt 552181 ccaaatgatg tcacaacgaa agatttggta catgatgtac gcagtttatc agataaaaac 552241 ggagtagatt tgcttgttac tggatcaact gcagtgaata ttgacatttc agatcgcctg 552301 aatgatgcga taccggtgtt tgctgtactt attgttggct ttgcgtttgt attgctgacc 552361 atcgttttcc gttcgctgct tgtgccgctt gttgctgttg caggtttcat gttgacgatg 552421 acagccactc ttggaatctg tgtatttgtc ttgcaagacg ggaatctcat cgactttttc 552481 aaaatacctg aaaaagggcc gatactcgcg ttcctgccga ttttatcgat tgggattctg 552541 ttcgggttag ccatggatta tcaagtattc cttgtcagca gaatgcgtga agaatatgta 552601 aaaacaaaca atccagtaca agccattcag gctggattaa aacacagtgg tcctgttgtt 552661 acagcagccg gcttgatcat gatcttcgtt tttgcaggat ttatctttgc aggcgaagct 552721 tctattaaag ccaatgggct ggctctttcc tttggtgtac tctttgatgc ctttattgta 552781 agaatgacac tgattccaag tgtcatgaag ctgatgggga atgcagcctg gtatttgccg 552841 aaatggttag acaagattat tccgaatgtg gatatagaag ggcatcaact gacaaaggaa 552901 atacagccgg aaatagatca tgaacaaaag aaacaaatca gtgtgtaata gaaaaagcag 552961 atcttttatg atctgctctt ttgcttatgg tagtatttag aagatgaagt cggcagttaa 553021 aaggagacgc ttatggcgcc atcactcatt ttcgatatgg atggaacttt gtttcatatt 553081 ggcagaagct gcatcatact agcaggcatc ccaggagaag tgacatgatt ttttgacttt 553141 gcattcacta cttgatgcca aggatcttga gaatccttct tgaaaataaa ggattttaca 553201 actgatcata taagaaacct aaagaaacaa gcacacaaaa ccagctgcgg gttttgtcca 553261 agaaaaatag agtccataag agggactcta ttttttgaag tgcccggcta gaagcatatt 553321 gcaggacttt atgaatgcaa atcactatct tataagccct taccgtgaaa tgcctgtttc 553381 tgcattgaaa aaacgcatta cacgttcatt tacgtaagtg ggttgttcca tcgataaaac 553441 atgtccggca tttttaatga cttccgcctc aatatctgga acgaatgaag aggctcggtg 553501 cagggctgag tggggatcat agatgacttc atgttcacca agtaataata ggataggaac 553561 tcttgctgaa cgtaattcct catcggtaaa aacatacgga aatccgtcgg cattaggatt 553621 tggatttctt gatccatcct gccacattac ccctgcctta aactgcttca caaaaatcgg 553681 gtgcagcaca ttctgatcat tcatcatcca atttaagaat gtttcaactc catttgacgc 553741 tgtaaggcca agagcgtatt tgtagaaatc gtgatgaaat ggcaaaaacg tttctgccgg 553801 actcagtata gctgcgcttt ttactctctc aggcatacgt aaaaggaaat tcatcgtatg 553861 gagaccgcca agcgaaagtc cgatcatgtg ggacttttcg atccccagat tgtcaaacac 553921 atcaagaagc caattggcgt aatccgttct tgtaccgctt acattctcag gaatactctt 553981 gtttttatca cctatgatat caactgcata agttctgtat ttactgctcc aatcggcgat 554041 gttgggatac cacatcgtcg agctgaataa tgctccgtgg agtaatacaa gcggcggggc 554101 atcctctggg ccgcttgcaa tcacatgtgt ttgaccaaaa cgagtagata tatagaatga 554161 tttacaacgg accggccaaa gactaaggct ttcattataa gtttgataat agcggatacc 554221 gttgtcactt aattcgggaa tactagatga atggtttgac atacaaatgc ccctcccaat 554281 tttgtttaaa tgaatgtgcc gtttcgtgat ggggaatctg attttgatat aacagacttt 554341 atttacaata taatacagtt gttattagac gtcaaatcca agatgaaaag gaaaaaaacg 554401 attgaaacag attattgaaa atcaatataa cagaatatta acctcctttg tggagccgct 554461 tcattaaaac cgcaatccaa atgcatgaat cacaaaaatc acaacaggag ggatcaggag 554521 ggaaggcagc agattcagtg ttttgaactt cttgattcca agaatgctta gacctgaact 554581 gaggatgagt atgcctccca caattgtgat ttcattaata aggtctgtat tgattgcgct 554641 ctccattact tgtgcaaata aatagatgga gccctgccag gaaaataata caagtgcggc 554701 agccgctatt ccaaaaccaa aagttgaagc gagcacaatg gaggtgatcc catctaacat 554761 cccgtttgtc agaaggtatg tataatctcc atgcaaagcg gcttcaacag ggcctaatat 554821 tgacagcgaa cctatacaaa ataataagac cgcagttgat aagccctctg ctaaattgct 554881 tttagaaaat ttgttcacca gcttgttgaa tcgtaattct aaattgatga tctggcctag 554941 caaacctcca atggctaaac tcacgatgaa tagaatgggg tatttactat caggcaaatg 555001 ctgtgtaatg gcgttgatcc ccagtgcgac cgcagcgaat cccattgcct gcatcaaaat 555061 atcctggtat tcatctttaa tgcctttttt gaatatcccc ccgattatgc ttcctgcaat 555121 gatcatcact gtgttaaaaa tcgttccaaa cataagcttt ctcctccaaa aatcattcct 555181 gcataaaaaa taaaccctct agttagtaga gagtcaaggg agatcaaaac atattcatga 555241 gattatttga tgggcagcag gatttcagtc acgtaattat ctaggttatt cgtaatgcca 555301 taatcaatga gtgtgatttc gattgagtcc cctgctacct cataatgatg ttctttcata 555361 tatgccagta attttttgta gtatggttcg gcttctggat gtgacccttt aaacctaatt 555421 tgcagatatt ctcttgaagg aaagatgatt tctgaagaag ttttttcatt ttcatcttca 555481 agaatcataa atatactgga atatttgtca aactgttttg ctttcacatt tgctgcagaa 555541 atggataaac caatcttgcc tatgaatata tcttcgttta cattcaggtg ggttctcaat 555601 tcagctaacg aatgttcgat atcatggccg agaacatatt catgctgcaa ataggccaca 555661 cgcattgcgg gaagtttgat ttttgaaatt tgatgtaacg gcatgttaac ggcatcttct 555721 atatgtgtga tgcgtcggga gatctttcgt tcaatgcgtt ccaattcttt cttcttgcga 555781 tcaatttcaa cctgctggct ttttagtaaa tgaagaagag tgtttgtatt ttgagagtta 555841 taaaaatcaa gaagcttatt gattggcagg cctagggccc tcaaatactt gatggtatcc 555901 agccgctcaa actgttgggt agaataatat ctatagttcg tttgctcatc tttatattcc 555961 ggtttcaaaa ggccgatttc atcataatac cgaagagcag agattttcac attgaataac 556021 tttgacactt ctccaatcga aaaaaattcc ttcattctaa caacctttct gtcctatgat 556081 tgatatacac acattatata gtacggcgag tactaaaggt aaagtttgca gcataaagaa 556141 aaaactcctt ctaaaaagga gcttttcatt cttcgaaata aggatttaca tggatgagca 556201 cttcttctac atctgaaaac tgtcttttga tttcatttcg aatttcgcgg gcaatgtcgt 556261 gtccctgctt aattgtcaaa tcatgatcca aagataaacg gacatcaagc aatttatagt 556321 ggccatgttc tcgcgcgcgg attctatcaa ttcgttttac ctgatcacat tgaaaaataa 556381 cagctttata ttcctctatc agctcgggat caacactctt ttccatgagc acatcaacag 556441 acggcctgat taattccatt gaaatcttaa aaatgaggta agcaacgatt gcactggcaa 556501 tggcatcggc gtacaacaga taggaccatc cacggctgtt tccgatgata gccaacagga 556561 cgccgataaa agcggcaaga gaggcaacga tatcgccttt atgatcgtac gcaatcgcta 556621 taatcgcttt gctgttccat tttttccctt gctttataga ataacgatat aagatttcct 556681 tagccacgta cgaaatcaga gccgcaaaca atgcgctgta ttggggaacg cttggccctt 556741 taacaaagga cagaatcgct tctatgagga tataaacgga tacgatcact aagataattc 556801 ctacaatcgc ctcactaatg acttcagctt ttccgtgacc aaaaggatgg tcttgatcgg 556861 gcggtttatt ggaaattccg atcactgcca agactgcaat cgaagcaacg acatctgccg 556921 cggaatgtat tccgtctgca aacacggctt cactatcgcc taccagccca aaaaagacct 556981 ttcctgccat taagatcaga ttggcgatca atgcaatcaa agcaactttt ctgcttattt 557041 gttctctttc acttgccatt ttttcctcct ataaaactgc acaaaaaaat aggagtgctc 557101 tatatacgct ctccgtatcc tttcctgtgt aatcactttg tttatcatac caattcaatt 557161 tcgagtgggt ctatagcaac gttgtttcct gtttactaat aaataaggtg acagaaaaaa 557221 agttggagct atgctaaaaa ggtcatacag caaacaaatg agttcttatg taacaacagt 557281 gatgattcgc tattaaaatg ctgccgtcag tgaaaaattt ccacctaatt ttcaaaaacc 557341 tattgacatg agaagatctg tattttacta ttatctcata ttcaagatat tttaatttga 557401 gatatttggt cggaaagatc agcgatcaag cgcaactcta agtgttcaat cgttgtcagt 557461 tcttttacac aatattcaat atgatttttt ataacataat atctcgaatt cgagataaaa 557521 gggagtgtag cgtaatggct gaatttactc atttagtcaa tgaaagacga tctgcaagca 557581 attttctttc aggtcatcca atcacaaaag aagatctcaa tgagatgttt gaattggttg 557641 cattggcacc atcggctttt aatttgcagc atacaaaata tgtgacggtt cttgaccagg 557701 acgtaaagga aaagctgaag caggccgcaa acggacaata taaagtggtt agctcttctg 557761 cggttctctt ggtattaggg gataagcagg catatcaaca agcggccgat atctatgaag 557821 gtttaaaggt attggggata ttaaataagc aagagtatga ccacatggtg caagacaccg 557881 tttcgtttta tgaaaacagg ggagaacaat ttaagagaga tgaggcgata aggaatgctt 557941 cactttctgc gatgatgttt atgctgagtg ctaaggaaaa aggctgggat acctgcccga 558001 tgatcggctt tgatgcggaa gccgtaaaac ggattttgaa catagacgac caatttgagg 558061 ttgtcatgat gattacgatt ggaaaagaaa aaacagagag cagaagaccg cgcggctacc 558121 ggaagcctgt gaatgagttt gttgagtata tgtaaaagga gcggataaaa atggctaaaa 558181 aaacgatggg aattcatcat attacagcga ttgtcggtca ccctcaagag aacacagatt 558241 tttacgcagg agtgcttggg cttcgtttgg tcaagcaaac tgtcaatttt gatgacccag 558301 gtacgtatca tctttatttt gggaatgaag gcgggaagcc gggaacaatc attaccttct 558361 ttccgtgggc cggagcccgc caaggcgtca ttggagacgg tcaagttggc gtgacttcgt 558421 atgtcgtgcc gaaaggggct atggcatttt gggaaaagag actagaaaag ttcaacgttc 558481 cctacaccaa aatcgagcgc tttggggaac aatatgtaga atttgatgat cctcatggac 558541 tgcacttaga aatcgtggaa agagaagaag gagaggctaa tacgtggact ttcggagaag 558601 taacgcccga tgttgccatt aaaggttttg ggggtgcaac cctattatca gagcagcctg 558661 acaaaaccgc tgacctttta gaaaacatca tggggctgga gcgagtcggc aaagaaggag 558721 acttcgttcg ttatcgttcc gccggtgata tcggaaatgt gattgacctt aagttaacgc 558781 ctattggccg cgggcaaatg ggggccggaa cggtgcatca catcgcttgg cgggctaacg 558841 atgatgaaga tcagttagat tggcaaagat atattgcttc ccacggatat ggtgtaactc 558901 ctgttcggga tagaaactac tttaatgcca tttacttcag ggaacacggg gaaatcctgt 558961 ttgaaatcgc aactgatccc ccaggctttg cacatgatga aacacaggaa acaatgggcg 559021 aaaaactgat gctgcctgtg caatatgaac cgcatcgcac acaaattgaa caagggctgc 559081 tgccgtttga agtaagagag ttagattgat ttgacacata aaaaataaag aaacatatat 559141 tcaattgatg attgctggat ggtactgtca gcaaagaatc agataaaatc aaagatgagg 559201 agagatacaa atggaagatg caggactgtt gcttattcgt ataatgattg gtgtggtgtt 559261 tttgttttat ggcacacaaa aattattcgg ctggtttggc ggatacggga ttaaaggaac 559321 cggacaatgg ttcgaatcaa ttggggtgaa accaggaaac gttgcggccg ctctatcagg 559381 tcttggggag ttagtaagcg gaattctatt tattttaggc gtattcctcc cgcttggagc 559441 tgctatcata acaatcatca tgttaggtgc tatcgtaaaa gtccatggag cgaaaggttt 559501 tgcgaatggc gccggaggtt ttgaatataa cctggtgctc attgcagttt ccataggggt 559561 tgcactcatc ggttcaggag cttacgcttt gcatttttaa tacgaaagta tgtaagaaca 559621 gttgctgctt gtcagtaact gttcttttat tttcacattt tcggcaagct tgcaggtact 559681 ctgcaaagca aaaaagcgga tatcataaat ataaatctgt atagtgaatg atacgtattg 559741 atgagcttgg tcatgaaaaa cagacctatt tgaaggagta aatggatgaa agagatgaca 559801 ggattacatt cattagtttc tatagaaaac tttatcaaac agcacaaatt cagttttatt 559861 tatatatcaa ggcctggctg tacagtatgt cacgcagttc tgccccagct cagaatagta 559921 ttggatcagt ttccaaacat caaattgggg catatcaatg ctgacgatgt agcagaggtc 559981 gccggcagat tttcagtttt caccgttcct gtgcttcttt tgttcattga tgggactgag 560041 tttctaagag aagcccgttt tgttcatttt gaacagcttg aacaaaagct gaaaagggtt 560101 tatcgattat atgaaggcga ataaaggaat aaggcaaaaa aagaactcaa atgagttctt 560161 tttttattct tcactaggcg aagaagggtt atcaacctgc ccttgatcac ttgtatcatt 560221 atcacaactt gctgaaataa taattgaatg agaaggagag taatctccta atgtgaaatt 560281 cactccgtaa tttttgctgt tcgcagtatg gctgttttgc aagttttgtc cgatatctgt 560341 attggcgttt tgtgtcattc catttatcgt gagatttgag atgttgattt gagatcgcat 560401 gcttcaaaaa ctcctttcac tcagaagtag ctgtcataaa ggacgctggc agtctattta 560461 cttctatgat attgcgtttt tatatcattg catcaacata atggtaaaaa taatagcgag 560521 tgaatgatca tcttttgaag atgatcaacc tatcagcaga aataaagccg cctgataaag 560581 aggcggcaga tcgttatatg tcatctatga atttgatgta tcgtttttcg tttgcctgaa 560641 ggataagata gtcgttttta atgatgagta ggagcctata gcagcgtagc cataaaacca 560701 gcccataaat acgccagaaa agaggctgtg tcgatggctt atgaaaacag aaatgacaag 560761 gcctgttatt aaggcaactg acggtacaaa agttttgggg attttcaata atattttgag 560821 gatttgggtt atcaatatga tgattggaac agctatcaca gcatcccaaa agttcgtgtg 560881 aataattgga aaagccatac ggcacctcat gaagtgttta tttcttaatt tttacgctaa 560941 aagcttggaa agcagctctt ggatcgcata tgttacattt tgggcttgat tggcggagct 561001 tgtttggctt aaagcattgg attcaaaaac caaacctgta ttactcccac cggaaccctc 561061 tgttgtttta gacacagaga acgggctgat ggaaactgca aatccgttat taaaaacgct 561121 gttcccggat atcgaatgaa tataaactgg gaatttcatc attcatctct cctctctgtt 561181 atgactgttt atacaatatg gtgtgtgagc agcagttgct taaacaaaac ggcaaaaact 561241 ttcagtaaga gacaaaaacc tgcaaaatgc cacaagcgcc ttttgttaat gcagcttttt 561301 agggacgttt tttttatttt ttttgccaac ttcatcaaaa atattctgat tgccagactg 561361 ggcttgtccg tccttattta tgaaatcggg gtgaatgagt tttttcagat ccctgactgt 561421 taaaggcttg gcgtcatcag ttaattctat tcctaattgc ccgtttgcct ctaatgtcgc 561481 aattttgaca tcttgtatag ccgtaacgcc gtgaagcctt agctgcattt caagctggtc 561541 agctgtaagt ctcatcttct ttaagttttc gatatgaagc tgtccgtttt caatgacgat 561601 ttttgctttt ccggttaaca tcttttcaat ggtgttcgat ttcatttgga tccattccat 561661 aacgatgagt gtgcttgtga aaattgccgc tgcaattaat gttttgaaga ggctgtactc 561721 gatgattggc tgaacgataa tagttccgat cgaaatcatg acaaccgttt gagtcgacgt 561781 catttgtgcg attgatttcc ttcctgaaat tctcagcaaa atgaccccgg ctacaatgag 561841 aacaagagat tcccaagtga aattcatgct accacctgac caatgatgaa ttagatttgt 561901 catgggattg gcttttcttc cggccaatcg caatttaata tatccgaaag gcagtcggtt 561961 cattctgtcc tgaaccgaac aatatttttg gtatagatgg atatattaag ccaaacaatg 562021 atagcaacag gagttttttg gccgaaacaa tctgggaagc ggggagcgcc ataacatgat 562081 tgaacttgaa gttgtcatta gaacggttgc cagctttggc ttgctgttaa tcgcagaacg 562141 aattttaggc aaacagacaa tctctcaaat gacgattttt gattttattg cggcgatcac 562201 actaggggcg attgctgccg gattagctta caatacttca ataaaaccgc acaatatggc 562261 catttcgttt agtatttttg tgctaaccat ttttctaatt tcgtttctgt cgataaagaa 562321 caggaagctg aggaaatttt ttgccggaga tccaacagtg ctgattcaaa acgggaagat 562381 acttgaatca aatatgagga aaatgcgtta cacacttgat tatttaaatc agcaattacg 562441 ggaaaaagaa atatttaata tcgaagaagt tctttttgcc attcttgaaa cgaatggtca 562501 gctgactgtg ttaagaaaac cgcaattccg gcatgtgacc aaacaggatt taatgattgc 562561 ggtaaaccaa gaacaaaggc ttccgataga acttattatg gacggagaaa tcattgagaa 562621 taatttaaag cagaatcgtt tgacggaatc ctggcttttg gaagaattgc gaaaaagaga 562681 cataaaggtg aaagagaccg tgtacgcagt gctgctgggt aatggggata tttatgtgga 562741 tcaatataaa gaccatatat cagtccctat ggataaggaa tgaaggaaca atcaatctta 562801 aagcccctta ttgaacgcaa cggtttcaac ttgtcttggg tacgaaatat gcagaagccc 562861 gtttaacagc tgaatctgta acaaatgagt ttcagcggct tcgggaagct gaatgattcg 562921 ctcaatttct ccgtaatacc gttcacgcag cacttccatt tcggctggaa aaacaggcgt 562981 gatcgttcct ttgatcagca gctgggtttt agacagtaaa cggatcgtta attcttcctc 563041 atacacaccg ggcatttcca caatgataaa attatattcc tcatcttgat aaaagtcgta 563101 aacaaacgta gaagcttcgg aatcaaaaaa atgttccggg gctttatatt tgagcacatt 563161 tgtccaaaag tcactttgtt tatattcatt cgtaatctca agccactttc gaattttttc 563221 gaaatccata tgagattctc cttaaatttg atttgaaatc ggcgcagaag ggtttccgat 563281 ttggtcttgg tcactaacgt ctgaatcaat atttccagtg tttaaaagtg aagacgtagg 563341 cgaaagatcc cctaaggaaa agtttgctcc aaaatatttg ctgttcgcag tatggctgtt 563401 gtgcacagtc ggaccgacat ctatatttcc gttttgcgtg acgccgttga tcttaatatt 563461 tgcgatatta atttgatatg gcatagacga aaccccttta atctaaaatt ggcggtggtg 563521 caatcggagg agcattaacg ttggatgtat cagagttgcc gatagatgtc tggtcattta 563581 catcaggatc gtttaagaag ttttccatta cggattctgt aggtgatgta tcaccgaaag 563641 aagagttggt cccttgagat ttttgattgt tggtagggct gttataagca gcttcgccta 563701 ttgtaattga accattgccc gaaatactgt tgatcttcaa ataatatagg ttgattactg 563761 tagacggcat cccatcacac ccttccatct ttctgtacag tacattatgc gccgctgcac 563821 ccaattgttc cttgcattta cgggcaaaac tctatctggc cccggagtga tgctcaatta 563881 tcagtgaatg aaaagccatt gatataggaa tcaatgaatt gattcagtta ttcgaaatgc 563941 atgagacctt ttaataaagg aagctggcaa acaggatcag tttgaaataa ttgacaatga 564001 agctaatgcc atgaaataat actcgtgagt aacattactc gtgggtatta tttttggggt 564061 ggtcctagtt gaaaagtaaa ggagtagaaa gccgaaaacg attacttaaa gctgccgcta 564121 atgaattttc ggttcgggga ttccatgacg cgaaggtaag tgaaattgtg aaaaaagctg 564181 ggttcacgca gccttcattt tacctgtact ttcaaagcaa agaagccatc tttgccgagt 564241 taataaccga ttttcactct cgagtcagaa agctgacaga gtcacttctt ctggaaaacg 564301 gattaaacac ggaggatgtg tcaaaacggg tactgctagc tgtagagact gtttttcaat 564361 ttttggatga ggacaaggat ttaaccaaga tcggcttttt tctcaacccg gaagcaaaac 564421 aaatgaaaaa agacttggcg atggttttga aagagaactt agaagcagaa cagcggcttg 564481 gctattttca ctctgaactg gatatggaaa ctgtcgctga gtgtttggtc ggcatgattg 564541 aacatttaac cgaatcattt ttgttaaccg gaatcaaaga tccggcaagc ctcgcagcag 564601 aggttgtgaa tcttttaatt tacgggatgc ttccgaaagg gaatgatgta agatgatatc 564661 tattatgatg aaagtcagtt tggcagtttt tatgcttgcg ggaggcatca taaaggtaag 564721 ccgcgttccc tttcaagttg agcattggcg gcattatcaa tatccattat ggtttctgac 564781 tgttactggc attcttgaaa tagccggggc acttgctatg acagcgggaa tttggaatcg 564841 gtatgcagca attggagcag gtgttctgtt tgtcgttctc atggcgggag caattcatgc 564901 gcatatgttt cgagcaagac aatctgtcat catggcgata caagcgatga tttgtttgat 564961 tgtttcaatc atgatcatca tggggagtta cacgtaagct tttcactaat gtttaagaac 565021 aagcccattt gcaggaaatc tccttttctt atcgaataat agaaagtcca ggaattaact 565081 gaatcagtaa aatagagctc catttctgtg ttattcgtcc ggcatcagct gggctttttt 565141 tataaaggag gaatacagga tggcattcac tttggaagac atgactgagg aagagttcga 565201 agcctttcgc gggatgtccg tgcaaaattt tgcgaaacaa aacataacgt caggaacttg 565261 gacggaaaaa gaggcatttg agaaatcgga gcaggcatat gagaacatga ttccgaatgg 565321 gcgagacagc agcaatcatt atttttggaa catcacaaat gaccaaggag aaagaatggg 565381 ctggctctgg ctgtatgctg atccattaca tccgcaaaag gaagcgttta tctattcctt 565441 tggattgtat gaagcctttc gcggaaaagg acttgctcaa ttggcgcttc aaacgcttga 565501 tgaaagagca agagagcttg gtgcggaaag gctggctcta catgtatttg cacacaacga 565561 gacagccgtc tatctttatc agaagatggg ctatgccatg accaatatac gtatgcggaa 565621 acagctatgc tgaaaagccg cttacgttac ccaaatacaa catgcctatc tggaagcggt 565681 ggcagggtac tataagtcat cattagaaag attaaggtca tgggaggctt gaacatataa 565741 agaaaaagga caacagctgt tgtccttttc aatgccgctt gaactttctc cctcagtctt 565801 ttttgtcttg atgatccagc tcttttattc gtttcgtaag ctcattgaaa gcctgatcaa 565861 gctccttata ccctttatca tttggcgtca taaaactgag ctttcccagc acttcttgtc 565921 tttctgtctc aagctttaac cgaagctcct cccgctcatt tctttctgaa ggaacgtcgt 565981 ttaactgctt ttcgatgccg ttgtttgaga tgacgagttt actgtttgtt gttttttcga 566041 gaaagtatcg gtcatgtgaa accgccagca atgtgccgct gtattgtgac agtgtttctt 566101 ccagctgttc gcgtgacggc aggtcgagat ggtttgtcgg ctcatctaaa atcagcacgt 566161 ctttttcctc cagaatatat gccatcagct tgatctttac acgctcaccc atactcatat 566221 gcttgatcgg ttcagtccat tgggcggctg taaaacctaa gtgcctcatc agattttgaa 566281 cgtgccccct tgctttgaat gtttcattct caaataactc ttccggtgtt tgttctaaag 566341 gcaaatcaaa cacctcctgc gttaaatagc cgatgtttgc ggacggcgac acccatacac 566401 ttccttctgc tgtttcctgt cccagaatga tgttcagtaa tgtcgttttt ccgctgccat 566461 tggggcctat gatcgcaacc ttttcgccgt gctgaattgt aaagtttgcg tttttaaaga 566521 gagtcctttc tccaaacgct tttgttacat tctgaacttc taaaaaacgt tttcctgttt 566581 tgtgggttgt atcgattgaa aagcggactg tatattctgg ggtaacgggt tccgcctttg 566641 ctttttcaag ctctttttca agccgcttct gcttggattt tatctgggca tccgtacgct 566701 tcgcttttac ccggtgatat tctttaaacc cttccttttt cgtcgattga gcatgggctt 566761 tttccgacca agaagcgagc ccattcattt gtgcttcaat ccgttcaacc attttttgct 566821 gcttttcata ttcacgctgc tgggtgagtc ttttcttctc ccggaacttc atatacccgg 566881 agtaattccc tttgaattca atcagcgtct gatcctcaag cgaccatatt tttgttgcgg 566941 cttcgtctaa aaaatatcga tcgtgagaaa cgagaatcac agtgccgtta taatgtttca 567001 gctgttggat gagaaattgc aagctttttt catcaaggtg gtttgtcggt tcatctaaca 567061 gcagcagatc tgcatcctct gatagtcctt tcgccagccg cgctttcagt ttttcaccgc 567121 cgcttaactg atgaaaatca cgaagaggca catgccattt ctccagtaac ttcttttcgg 567181 caggtgtctg atccgcaaag gaatacgccg cggtttcctg ttcaaccaaa gccagtttta 567241 tatccttccg aaggatttga ccctgtgcag gggctaagtc attgtgaatg aggtgcagca 567301 acgtagattt cccagcgccg tttttgccga taatcccaat gatatctcct tgctgaacac 567361 tggcgtttac atgtttaaaa acagtttgat cctttacttc atagctaacg tttgttaatg 567421 ttacgatctc tttcatccat atccctcgct ttaaagggag aataaaaaaa tcctcccaaa 567481 tgtgttggaa ggattagccg tgcctgtgca tgatcaaata agctattttt tataaatagc 567541 agtgtcgtat atatagaaaa tgggcagact aatcctattt tttgatttga aatattgatt 567601 tcaaacggta aaaataagat tagttaatca ttgtccaccc atcatccctt cttgttttga 567661 ttacaaacac tatagcatac ctttaaattc aaaagcaaag gtcattttca tcaaaaaaac 567721 tcctgctctc atttttgagg caggagtttt gagtcttatt gatgcttcgc ttttctcact 567781 ttataaatca caatcagcaa aataaaccaa accggtgtga caaataagga aacacgagta 567841 tcctgtgcca gtgccagcac aaccagaaca aacgccagga acgcaagaat caggtaattt 567901 gtaaacggat aaagcggaag cttaaacttg tttgttttcg ctaattcagg tcttgttttg 567961 cggtatttca tatggcagat gaccgtaatc ccccaaatgt agataaagca tacggttgaa 568021 atacttgtga tcagggtgaa tacgccttct ggcatgatgt agtttaacgt aacaccgatt 568081 aaaatcacga tagctgaaaa gaataaagca tttctaggca ctttacgctg agtcagtttc 568141 gccattgact caggcgcatt gtgatctttc gccagggaat agaccatacg gcttgtactg 568201 aatacagcgc tgttgcatgc tgaagcagcg gatgtcaaca caacaaagtt gataatactt 568261 gcagccccga cgatgccaac agcgacaaat acttgtacga atgggctttc gctgggattg 568321 atgatatccc aaggatagat gctcataatc acgagaagag ccccgatata aaaaagcagc 568381 acacggacag gaatattgtt gatcgcctta gggattactt tttcagggtt ttctgtttca 568441 ccggccgtaa gcccgacaag ctcaatgccg acaaaagcaa acacaaccat ctggaacgag 568501 aggataaacc cgtgcatgcc attcgggaac aggcctccgt ggctccagag gtttgtgaag 568561 ctggacactc ctgagcttgt ggaaaagcct ttgaaaatca tcacaaggcc aatgacgatt 568621 aacgccaaaa tggcaatgac tttaatcaaa gcgaaccaaa attctaattc tccaaaaagc 568681 ttgactgtcg ccagattcat aatcagtaaa ataataagag cgattaagcc aggcacccat 568741 tgcggcacac ccgggagcca atattgagtg tagagcccga ctgctgtcag atcagccatc 568801 gcaatggaaa tccagcagaa ccaatatgtc cagccggtga taaaagctgc catatcgcct 568861 aggtagtctt gtacaaaatc cacaaaagag tgatagttca agtttgataa cagcagttca 568921 cccagcgatc tcataattaa aaagcaaatg atccctgtga tcatataagc aaataaaatc 568981 gaaggtccgg caaaatgaat cgatttgccc gagccgagaa ataagcctgt cccaatggct 569041 ccgccgatgg cgatgagctg gatatgcctg tttttcaagc ctctctgcaa cgtttgctga 569101 tttatattgt ctttcgtcat gtcgtctgtc actttatgtg ttcctccatt gaaaattgtt 569161 tattgagtca gcaatctatt tttaatgatt attataacac taaaatttct atctttttta 569221 ctaaaaaagg attgatgaaa agaattttaa tgtgatttgg actatttccc gaaaaaagcg 569281 gctccattta gggagccgct tttttatgct ttttcagttt ttgtcataaa caggtagagc 569341 ccgtaatctg tcggtgcgga tgcgtagcct gcctgccgca gcattgctgt gatattgccg 569401 cggtggtatg tcccgtgatt gacaacgtgg ggaagcagtt cggaaacagt tgttttcatg 569461 attccgcttg agggattttg aatctggagt ggcttattga gctgttcttt ttgctgtaaa 569521 aatagtatat agcgctcgga taacctcaga aaaaggtctt ccatttcctc tatttcttta 569581 gcctctgtct gttctttaag ctgttcagct aaagccaacg catcgctcaa ggttttgccg 569641 gaaaacactt caatccagcc gagatcagaa agataaacat gagacaatac atgggatatt 569701 gacggaaaca cgctttgaat ttcttgatgg tatatctctt ttggaagctc ttttaatcgg 569761 ttgaatattt gttgattggc ccagacgtta tattcataca atttgaatgc aaaatctgac 569821 atgttaaaat tccccctttc gtgtgtatag ctttcattat acacgaacat gagttcttat 569881 gtagagtgct cgaaaataaa atttgttgac atatatagtt tagaggaata aactaattga 569941 cattgaacat aaagtttagc ggggtaaact ataatgagga ggggaagata ttgaatgaac 570001 aaaagctatg tcaggcgata aacctgtttg tggaagtcct gcttgaaggg acagaatttg 570061 tgcatcgtga aatcaatcag gatgtcttca agcatatctc aagggaacag gcagacctgt 570121 tgaaaatttt aaaagtcaag ggcccaacct ctcccggcag cctggccatg taccaaaatg 570181 tacataagag cgcgatctct aacagactga aaaagctgct cgaaaaggga ttggttcaat 570241 gggacgactg tccggaaaaa agtgataggc gctctaagct tattaacatt acacccagtg 570301 gtgaacacat actagaagaa ttagattctg ccatctttaa cgcgctcaaa ccgttgattg 570361 atgatataga tgaggaacac ttacattcta tcatcgagat attcaccatt ttaaaaagca 570421 aatttaaagg aggagattct gccgaatgag agcaatcatc aaattcaagt gggcaattgc 570481 agccatagta ttagcactta ccgtcgtttt gagtttgttt tctccgaact taacggagct 570541 ggccaatcaa aaggggcagg cccagcttcc cgctgatgct gtttcagaaa gggcaaacgc 570601 cattttaaaa caagcgggag aagacaataa ttcgatcagt gtagtcttta cattagacaa 570661 cgctataaag aaagaaacag agaatcagct ccggataata attgataaaa tcaaaaagat 570721 cgacggtgta gaagaggtaa catctcctct gtcagcggaa aaagaagtca aagaccagtt 570781 gatgtcgaaa gacaagaaaa ccgttctcat gcctgtcacg attacaggtt ctgataaaaa 570841 ggcggaaaaa attgcggacg agatttatca aatcgttcct gatgacttga cggcatatat 570901 tacgggagct tcccttatca accaggattt cgctcacagc tcagaggaag ggcttaagaa 570961 aacggaagtg ataacagtct gcctgatcat cggtttactg ttgatcgtgt tccgatctgt 571021 tgtgacgcct tttatcccga ttgtggttgt cggtttttct tatctgatca gtcaatctat 571081 actgggcatc cttgtataca atgttgattt tcctatctcg acgtttacgc aaaccttctt 571141 agttgcgatc ctgttcggca ttggaacaga ttactgcata ctgcttctta cacggttccg 571201 tgaagaattg gcaaacgggc atgataaaaa agaagcggcg cttatcgctt accgcacagg 571261 gggaaaaacc ttatttatca gcggatttgc ggtattgatc ggattttccg ccttaggatt 571321 tgcgaagttt gcgattttcc aatccgcagt aggggtagca gtcggtgtgg gaattttaat 571381 gatcatcctc tacacactgc tgccattatt tatggtgacg ctgggtgaaa aattattctg 571441 gccttctaag aaagtgctgt cacacagtga taacaaacta tgggcgtttc tcggcagaca 571501 ctccgttgcg cgtccgtttc tgttcattgt catcacggtg gtgattacgc ttccgttcat 571561 cttgacctat gatgaccaga tttcattcga ctcaactgcg gaaatcagca gcgattataa 571621 atctataaaa gctctcgagg ccattaagga tggattcggg gaaggaaaag cgttcccgat 571681 caatgttgtc gtaaaaggag acaaagatct tacaacagct gatacaatcc cctatctagg 571741 aaatatcagc aaagcgatcg agaaagttga tcatgttgac tctgttatga ccattacgca 571801 gccgactggt aaaaaaatca aagatttata tattgataac cagctaggat cggtttcaga 571861 cgggctggat aagacggtga aagggattgc cgatgtccaa agcggattaa cggatataga 571921 aaacggactg aatcaaatgg cagggcaaac cggctcggcc tcaaatggag ggtctggcgg 571981 ttcactgggc gatgcggcag atggcttggg caaaatcaat cagcagctgc agctcgtgag 572041 caaacagatt tcccaaaccg gcaataccgc acagaccgtg cagcagctta cggcaataag 572101 cggacagctt ggccagattc aaaccggcct tgaacaagcg aaccaacagc tctcaggcca 572161 gcaggcacaa gccggaacgc tgacagaaag cctgaaaaag ctgtccgaag gcgtgaaaag 572221 cgcaaatgag ggcctgacga aagtctctga cggtattaca gcttccagtg atatattaga 572281 ggacatgagc aaaagtccaa ctgtaagaga tactggcata ttcattcctg atcaagtaat 572341 gaaggacaaa gactttaaga agtcaattga ccagtattcc tttgcagacg gcaaaggtgt 572401 tcaattaagt gtcgttctgg attcaaatcc gtactcagaa caagctatta cgacaataaa 572461 ccaaatcaaa aaagctgtcg caaacgaagt tgacggcact cctttggaga atgcacagat 572521 cgtgtacggc ggggtcacga gtatgaatgc ggacttaaag gagctatcca caacggactt 572581 ctccagaaca atggtgatta tgattatagg cctgtttatc gtgttaacca ttttgttccg 572641 ctcaatgatc atgccgattt atatgatcgc gtcattgctg ctgacgtact atacgtcgat 572701 atccataaca gaattaattt ttgtaaacgg cttaggaaac gcgggtgtca gctgggcagt 572761 gccattcttc agctttgtca tcttgatcgc gttaggggta gattattcga tcttcttgct 572821 ggatcgattt aaggaagagg tgcaccttgg cattgagcaa ggtgtcgtca ggtcaatgag 572881 caaaatggga tctgtcatta ttacagctgc cattatattg gccggtacgt tcgcggcgat 572941 gatgccttca ggtgtcaata cactgatgca ggtggcaagt gttatcatca tcgggctctt 573001 gctttacggc cttgtcatac ttccgctctt catcccggca atcattgcga cctttggaga 573061 aggaaactgg tggccgttcg gcaggaagaa aggaaaagag taatcgagag aagagtgatg 573121 aatggtcatc actctttttt catgactaaa cgactaactt cagacgtgtt acccaaaaag 573181 atcagacgat caaacggcgg ctgtacttaa aaacaaagag cccggaaaac attcccgggc 573241 tctttgtttt atttccattc tgcaattgta tcaatcggca gacggtagga agcatagcct 573301 tcgtctgctg cttttccgat agaaagtagc ataaccggta cataacgttc tttatctaat 573361 ccgaaggttt ccgcgatgtt ttctttatcg tatccgccga tcgggtttgt atcgtagcca 573421 tgcgcgcgtg cagtcagcat cagctgcatg gaaacaagac ctccgtcaat caggatcgtt 573481 tcacggttga cctgtgccgg aagcttttca aaatgtgcgg tcagcgcggc gatttgtctg 573541 tctttgacct cctgcggcat gtaaccaagt tccacggctt ttgaatagat ttcttctaga 573601 tagtctgcgt tgttcatgtc tgcaaataca gcgatgacag cagatgatgt tgtgacttgt 573661 gtttggttaa agcttgcaag cggtgcgagc ttttcttttc cttccgggct gtcaatgaca 573721 agaaaacgcc atggctgcgc gttaacagaa gatggggcag ttgttgcttc ctctaagatc 573781 tctgtcattt cttctttgct gatttttact gccggatcat agttgcggat agaacggcgg 573841 cctttcataa tttccataaa atcgtttgtt ttgatcatgt tgatacactc ctcttaagct 573901 tcgatattat ttatattgtt tcgcatgcgc gccagcacat caatgagcag gcggcgttct 573961 tctgcgctta catttgcgag catttccttc atgaaacgct ccttttcctt cttagaagac 574021 tcaattcgct ctcttccttg gtctgttaac cgaacaaggg tgatgcggtt gtcctcaggc 574081 ttgcgccgcc ttgataccat gcctttggat tccagctgtt tcaggtgtct ggtaacggct 574141 gcgctatcga tatttacttt cttttgaagg tcgctttgac tgatctcatc tgcatgataa 574201 agcaatgtca gcaattccaa acgagattgg ctgatgcccg tgcatgcctc gaacttcacg 574261 ccaatcacct tgttcacgcc ttgcagctga tataaaatct cggcttcctc tgaacaaaat 574321 gacgccaaaa cccatccctt ctttcctgtc aaaactatta attgatatat caatgattga 574381 cacgtcaatt aatatacaac gattgatttc atcttgcaag ccatttgcac ttttgaacaa 574441 cctcccagcg cataaaattc gctaggctag aacttagcaa aaaaagctgg ccgcttcttc 574501 agatgatgct ggtcacgatg attccctgca tcattcccat ttataggtgt tcggaatatc 574561 actttgccgg cccgtgctca agcggctttc acaggctgaa agttatgata caatatacaa 574621 atgtttcaca gcttcaatcc atagttggag ctgacatcca ttatataagg gactaggttg 574681 aagggaaggt ttgataacat gctgcacaat ccaactggaa aagaacgctt ggcactagcg 574741 tttctgctcg gcatgcttgc tatattgggc ccgcttaata tagatatgta tttgccaagt 574801 tttcctgaaa tcgcgaaaga tttatcagca agtgcttcac ttgttcagtt aagtttaaca 574861 gcctgtctgg tcgggcttac gatcggccag ctgattgtcg ggccggtcag cgatgcgcag 574921 ggaagacgaa aaccgctatt aatctgtatt tttttatttg cgttatcttc tctgttttgt 574981 gcactgtcgc ccaatataac aactttagtg gctgcgcgtt ttttacaagg cttcactgct 575041 tctgcagggc ttgtgctgtc tcgcgcaatc gtccgcgatg tgtttaccgg aagagagctt 575101 tctaaatttt tctcgctgtt aatggtcatt accgcggtgg cgccaatggt tgcgcctatg 575161 acaggcggtg ccattttgct tttgccgttc gcaacgtggc atacaatttt tcacgtctta 575221 atgatcatcg gatttttact agttcttctg attgcattga ggttaaaaga aacgcttccg 575281 ctggaaaaac ggattccaag ctcaatcgga acatccgtca aaacgatggg cagcctgctg 575341 aaggatcgat cctttatggg gtacgcgtta actgtcggat ttattcacgg gggaagcttt 575401 gcatatgtgt ctggtacgcc ttttgtatac caggatatct acggggtgtc tccgcaggta 575461 tttagtattc tttttggcat taacgggctg gcgattatat cgggcagctt tatcatcgga 575521 cgctttggcg gaatcattca tgaaaaaagc ctgcttcgta tagcggtcat tacggctatg 575581 attgcgacgg ctgtgctatt aaccatgacc atgattcacg gtcctcttgc tacattagtc 575641 atatccattt tcatttacat gattacgatc ggcatggttc tgaccagcac gtttacccta 575701 gccatggaaa agcaggggca ccgcgccgga agtgcaagtg cgctgcttgg aatgcttccg 575761 ctgctcctcg gttcaatcgt gtcaccgctt gtaggcatta atgagacaac agccgttccg 575821 atgggagcca tcatgtttgt gacagctgtc atcggctcac tggcgttttt tggattaacg 575881 aaagaacgag tagggcagaa ttcataaaaa aacctgacat gacgtcaggt tttttgtttt 575941 atttagaata acaacagcag gcctgcaatc gccggagtca aaaagatggc tgatttcaaa 576001 accacctttg gcatgaggtt ggtgaatttc gcgcctacat aggccccgca cattgtcccg 576061 accagaactt tgacaagtaa aacgtaatca acaaaacctt ctgtaatata tccgatgcct 576121 ccacctacag ccagagggat gatcacaagc atcgtcgttc cgacagaatg gcgaatggac 576181 agattcagca taatcattaa accgatttga ataaaaggtg ccgacccgat gccgaatgtg 576241 ccggaaagaa cgccggctgc aattcctaag atgaccgctc tcgtatacgt tgaaagagtg 576301 ctttgattca cttgagcctt ctcttttaaa ataaataatc tgattaaaat gagaattgct 576361 gataaaaata acattccagc cgtcaaataa tgaagcaaat cagccggaat aaaagaagtc 576421 agcttggcgc cgaaaaatga gccaaccgca gcaaagcctc cgactattaa gccgattttc 576481 atttgaatgt taccctcgcg atagtggctg tatgcccctg ataagcttgt aaaagccatg 576541 ccggcaagcg aagtgcctaa agccgtatga atcgggatat ggaaaagaag cgttaaaagg 576601 gcaatgacaa agccggctcc accggcgcca ataaagccta aaataattcc tagaagaaac 576661 ataacaagaa taatgagcat attttttcct ccattgaaaa gatgtaaaaa tgtaatcgtg 576721 cgctattctg gcggaggtat ggtgtcctat tgacgaagaa aaacacgccg ttttttcagt 576781 tgccagtagt ccgtcgaccg tcgttcagca aacatatcgt acctcaaatt cagggatctg 576841 acaaggcagt ttgttgcttc ccattaccat ctgttatatg attttgatga agaaaagccc 576901 ttgaatatat tcaaaagagg tattatatat ggacgatttt aaattagata agccgactcc 576961 ctactacctg caattttata accagctaaa aaaaatgatc ttcaacggga cttttaagcc 577021 tggggaacgg ataaacgaaa cacagctggc gaaaagcttt ggcgtcagcc gctctccgat 577081 aagggaagcc atgcgattgc ttgagaaaga tggtttgtta aaagcggatg accgaaatgg 577141 gttttcgatc acgtcgttaa cggcaaaaga tgtagatgag atttataaaa tcagaattcc 577201 gctggagcag ctggcagtcg aattagtcat agacgaagcg gacgaagaag agctgaccat 577261 actcgaaaaa cagcttgaag aaacagagaa agcgattcac aacggcacgg aagatacaga 577321 aatcattcgt ttaaaccaaa aatttcatga gctgctggtt gatttcagcc ataacagaca 577381 tttgaaaaat ttgcttgagc atgtaaatga cctgattcat ttttgcagaa tccttaatta 577441 taccggcgac caccgcgcag aaacgatact gcgtgagcac cgcaggatat ttgaagaagt 577501 gaaaaagaaa aacaaagaag cagccaaaca acatgtgctg gctcatttca atcatgactg 577561 tgagcatttg aagcatgtgc ttgaagaagg taaagagaat tgatttgtat gatccggtac 577621 caagggagag cagaaccctt ggtatttttt tatgtattca ccacatatct aagaggcccc 577681 gttaataaga ttttatgatg gtttgactaa cgaataatgg gggttaaata tgtttatcca 577741 tatcgtcggg cctggtgatt ctttgttttc gataggcaga agatacggtg cttctgttga 577801 tcaaatacgg ggtgtgaatg gtttagatga aacgaatatc gtgccggggc aggctctgct 577861 tatccctctt tatgtatata cagtccagcc gagagatacg cttaccgcca ttgcagctaa 577921 agcgtttgtg ccattagagc gactgcgagc ggccaatccg ggcatcagcc caaatgcttt 577981 acaagcggga gcaaaaataa cgattccttc gatctcaaat tacattgcgg gaacgttaag 578041 tttttatgtg ctccgaaacc cagacctcga tcgggaatta atcaatgatt atgcgccata 578101 ctcgtcttcg atttcaattt tcgaatacca tattgcaccg aacggcgaca ttgcaaacca 578161 attgaatgat gcggccgcta ttgagacaac ttggcaaaga cgagtcacgc cgctggcaac 578221 aataacgaac cttacatcag gaggcttcag tacggagatt gttcaccaag tgctaaacaa 578281 tccgacagcg agaaccaatc tggtcaacaa catttatgac ttagtttcca caaggggata 578341 tggcggtgtc acaatcgatt ttgagcaggt gagcgccgcg gatcgcgatc ttttcactgg 578401 atttttacgc cagctgagag atcgacttca ggcgggaggg tatgtgctga cgatagctgt 578461 tcctgcaaaa acaagtgata atatcccatg gctgaggggc tacgattacg gggggatagg 578521 agcggttgtc aattatatgt ttatcatggc ttatgattgg catcatgcgg gaagtgagcc 578581 gggtcctgta gcgccgatta ctgaaataag gagaaccatt gagtttacga ttgcgcaggt 578641 gccgagcaga aaaatcatta tcggagtccc gctctacggg tacgactgga tcatcccgta 578701 ccagccgggc acagttgctt cagcgatttc aaatcaaaac gcaatcgaaa gagcgatgag 578761 gtaccaagcc ccgatacaat attcagccga atatcaatca ccgtttttcc ggtacagtga 578821 tcagcagggg cggacgcatg aggtatggtt tgaggatgtc agaagcatga gccggaagat 578881 gcagatcgtc cgtgaataca gattgcaggc tattggcgct tggcagttaa cgctgggctt 578941 tacgccgggc ccatggcttc tgcggaaatt ttttacgatc agaaaagtgt aaaaaaagac 579001 accagagctt gggtgtcttt tttttgatta agtccagagc agcagaatag ttcattcatt 579061 tgtaccttgc atgggttgtg ttcccatttt acgattagta gtagtctgat caaacaaaga 579121 gtcagaatac gatttgagag ggagttgtct acatgaagac agtattgatt ttgaattttc 579181 ctgcggaagg ccatgtgaat cctactttag gcattacgaa agcgttttcc gataagggat 579241 atgatgtcca ttatatatcc actgaaaaat ataaaaaacg attagaagca gcgggagcaa 579301 cggtccatct tcaccgggat ctgctgcgaa cgacacctat tcatgtcggt tcgcccaatg 579361 gcattcttga tttcgtgaaa atccatatca aaacgtcatt ggacatttta cagattgtca 579421 aagacttatc taagagcatt caatttgatt ttgtttatta tgataaattc ggcgcggggg 579481 aattggtgag ggattactta gatattccag gggtctcttc atcggcgtct ttcctgtttg 579541 gcgaggagca tctgaaaatc ctgccgctgc atccggagtc tggagcgccg cttgaattgg 579601 atcaagagtg cgaagacctt ttggcaaaaa tgaaagaaac gtacggtgtt gccccgaaaa 579661 acctggttca attcatgaac aataaagggg aattgaacgt agtgtataca agccgttatt 579721 ttcagccaga aagtgatcgt ttcggggatg aatgtctatt tatcgggccg agctttccaa 579781 agagagcgga aaaaacagat ttcccgattg aacagctaaa agatgagaag gtcatttata 579841 tttcaatggg gactgtactg gatcatacag aggatttctt caacctttgt attgatgcat 579901 tttcaggctt taacggaaaa gtcgtcatcg ctgccggaga aaaagcggac ctgaccaaat 579961 taaagcaggc gccggaaaac tttatcattg ctccgtatgt ccctcagctg gaagtgctgg 580021 agcaatcgga tgttttcatt acacacggcg gaatgaacag cgtaaacgaa ggcattcatt 580081 tcagcgtgcc actggttgtc atgcctcatg acaaggatca gccgatggtg gcgcagcgtc 580141 tctctgaact ccatgcaggc tatgtcatct ctaaagatga agtcaatgcc caaatattaa 580201 aacaggccgt agatgaggtt ttgcgcaacg atcagtatac ggcaggcatt aaaaaaatca 580261 atcaaagctt caaagaatgt atggacatgg aagaagtgat ggagcggatt gatgagttga 580321 ttcgccaaaa aaacaaataa gaaaaagaac tcccgtacct tgtacgggag ttcttgattt 580381 aaaacttgat tttgattttt tgagcatcac tgattttctt atggttatgg tcaaagacgt 580441 cacttgtcgt gatttcgatc cacttgatct cttttgtttt cttctcagca tccgcggcct 580501 tatcatgagc atggccgctt gatgcgttca caataaagcc gagatttccg gacttttcgg 580561 cgccgccttc caattcgccg tttaactctt caagataaat atctttgttc caatcaaagg 580621 tttcacccgt atttgttttc atcaatgcaa tcggcgcaac atttactttt tttgtagagg 580681 tgttcttgat atcaacgaaa accttaacga aatcaaactc ttcatcgtgt gttaactcat 580741 gaaagtaatc aatcatgctg tagtccgggc gcaagtggat cagcttcatt tcttttactg 580801 ttaactccac gtcgccaatt ttataggttt tgttcacttg tttgatatct tttaagacag 580861 cttttccttt atcatctgaa aacgtttggc cgaccttatg caatgtccgg tcatcagtta 580921 cctgggaatt aggctgataa tcatctgtgc tgtccttctg ggatgaagtg ctttgcggct 580981 cagcttttac tgttttctcc ccgcctgcat gctgtttttc agtactggcg tttgatgagc 581041 agcccgcaag catgatagca aaaacgagaa ttgaaagaat tcttctcatg atgattcctc 581101 cattaaaaag agatcccgtt acttcataca agcaacggga caccttgtat tcttttactt 581161 atcgttaatc ttaatgttgt attgtaaagc cttgaaaaca tttttggcga tttctgtatt 581221 gtcgatttgg ccggcaaatg tctcactaga cggaccgtat gcatagacgg gaacatcttc 581281 accggtatgt ccgcctgttg tccatccagt gtgagagcgt ttattaaaga tgttctcgat 581341 tgcgttatcg atatccagta cttccttcga ttttgccgct tcttcaacag attgaatttc 581401 ggcttttgtt aaagccaatt tcttttgatc gatatatgtt ttcaacgttt tttcaacatc 581461 cgcgccgtca gcgatctttt ctgccataaa gtctggtgtg cgctttgcgg ctttaatggg 581521 ttcactgaac cagttgtaga tgccgtccgc accgatggaa tatccgccgg ttgagtggtc 581581 agccgttgcg acaaccaatg tgtgcttgtc ttttttagcg aaatcaatag ccgccttata 581641 agcttgttcg aagtcttcca tctcgctcat ggcgccaacg atatcattgt catggcccgc 581701 ccagtcaatc tggctgcctt ccaccatgag gaagaatccg tctttatcct tgtttaattt 581761 tttaatggct gtgtttgtca tatctttaag tgatggaata tccttcgtac ggtcaatctt 581821 tttaggcagg ccgccgtcag cgaataggcc gagaacttgg ctgtctttgt ttttcagcat 581881 gtccttgcga tcatccacgt agctgtaccc cgcctttttg aattccttaa tcaaattacg 581941 gtccttacgg tcaaaattgc tctttcctcc gcctagaagg acatcaattt tgtgcttgcc 582001 gttgaccatc tcatcaaaat aatcatccgc aattgagttc atattttttc ggctgtggtc 582061 gtgtgaacca aaagaggccg gagtggcgtg tgtaatttct gaagtggcca caagtcctgt 582121 tgcttttcct ttttctttcg cagcttcaag caccgttttg gcttctgacc cgtcgttatc 582181 aacggctatg gcattattgt atgttttaat tcccgcagac atagccgttg ccgccgctgc 582241 agaatccgtt acattttgtt caggatcatc ggggtaagtt gtttgctggc cgacaagata 582301 ctgatcaaaa gccgtaggct ccacaacttt tgtcttttta ttatccttta agtatcgata 582361 agcagacgta taagacacac ccataccatc accaatcaga acaataacat ttttaatttc 582421 gtcttggttc ccctttttct tttcctgggc gctggcttca ggcacactgc cgctggctaa 582481 gctgctgaac gcaattgatg ataaaaccgc gataggcagt aatttcttcg ggaatttttt 582541 caactggata acctcctaaa tatagatgaa tctcaatgac aacccaatta tatttttaaa 582601 ctgttaagct agtattaatc gattttaaag attggattta caagaataat gaactggcac 582661 ccttaaataa tggttattct tttatgagaa gttttagaag gaaagagcga tagtactaaa 582721 gaaataaatt ggaggaatag atactggccg tggataggcg gactgaaatc tgctatagtc 582781 gcatagaagc aacccgctta catcttgaac aatttaaagt attacgttgg aaagaggtat 582841 tgtgtaagca catgtctgag cagttcatat ggagtggcat cattttattt taggagggaa 582901 caacatggac gttttttctg agtacttagc ggggattgct gacccgttcc accgagaaag 582961 aacggaagag gtgttaactt ggataaaaaa taaatatcca aatttacata cagaaataaa 583021 atggaatcag ccgatgttta cggatcacgg tacatttatt attggcttta gtgtttctaa 583081 aaagcattta gctgtcgctc ctgaaaaagt aacgatagcg cacgtagagg atgatattgt 583141 gaaggccgga tatgattaca ccgagcagct gatacgtatc ccttggaacg gtccagttga 583201 ttatacgcta cttgagaaaa tgattgagtt taatattctg gacaaggcgg actgctccac 583261 tttttggcgg aaatgaagaa aaaggcataa catatgagct gtataaaata tgttacgcct 583321 tttcatttgt ctatttttcg ttttgatcat ctattgctgc ttttcatcaa acaaggtctt 583381 ttcattgagc gtaagctgac tcgcagaata atgattacct tgtttccatt tcacttcaat 583441 cgtaatatca tggccttcaa gctcatgttc atctaaccgc tctaaaaaag aaacggactt 583501 ttcttttgcg cttccatcag aaaaagtgcc tccagcataa tcatgcatcg ggatttccgt 583561 gtcagaactc agcagaactt catcatcctt ttttacaatc agtgattcca gataagtgtt 583621 gtctatttca attgtatcac cgatccaata aagtttgccg ctgtattcat tcggtgcatc 583681 ttcatttttt gtgaaaacag cttcccaatt ctgatctttg ctttctccct gccaatttgg 583741 atactccaaa cgaacatgat gaatcaggtg ataggaaaaa aagatcaagc agaaagcgat 583801 taataggaat gccgtgaaaa tgagagggta tttataatga ctggacataa aagactccta 583861 ttcgtttaat caattacctt cgaaaataga atttcatccc gaatcaaaat gccgttttca 583921 gccacctcgg gaatctccgg cttgagtcgg cgcgcttttt caactgcgtt cggaaacact 583981 gcggcgaatt gatagcctct cttttgataa aacgctatcg catttacatt atcattcgtt 584041 gtgataagct ttattcgttg acaatgtgca tgtttagcct tctcttcaac ctgctgaagt 584101 aaagctgtgc cgattccttt attttcaatc atactatcta atgaaataat ttcacaatct 584161 ttcccatcta ttgtgtatgt aatacagcca atgatttcgc cgctttcatt tactgcggca 584221 aatccatcta attcatcaca ccgaaaaatg ccgctggaaa tcgccatctc gggtgtaccc 584281 caatgcttgg caaaaaaatc ggtcaacata tgtttcgcta tctcattgtt tgggatgatg 584341 atcatcataa cactcctcta ttgaaagatt gcatatgtac tatcaatata aacaatatat 584401 aacaaaaaaa atagatgttg aggtgacggc atggaaatca gcgatatcat ttacgggcag 584461 caccatatag acggagtgct ggaagagctt atcaaaagcg ctcctgtgca aagattaaaa 584521 ggaatctatc aaggcggagc aagcttttta gtcaatcgaa agtggaatgt gaccaggtat 584581 gagcactcca tcggcgtgat gctcctcatc aaaaagctcg gaggaacgat agaagaacag 584641 attgcgggtc tgctccacga cgtatcacac acagcttttt ctcatgtggt cgacgttgtc 584701 tttgaaaatc aagcagaaga ctatcatgaa aacatctttc aacaagtcat tgttcactct 584761 gaaatcccgg acattttaca aaaacacggc tatcatactg aagaactttt atctgacgat 584821 tcaaggtgga cattgctcga acagcccgca ccggagctgt gtgctgatcg gacagactat 584881 acgctgcgtg atatgtaccg atatggacac attaacctgc acgaagcgca aacctttttg 584941 gatcatctta ttgtgagaaa cggaaggatg tttcctgata gtattgaagc cgccgaatgg 585001 tttgtcagtg tgtactacaa ggaagtaatt gatttctttt tgaatcctgt gaatgtatat 585061 ggatatgaat atttagcgcg agcattgaag gcagcgctgc ggcatgatgt catatctgca 585121 gaggatctgc tgaaaacgga ccaagaggta ctgaacatcc tgcgtgcatc aaaaaatgaa 585181 gaagtcctga gcttgcttac atccattcat cccggcatac aagtaataga ggatgacatc 585241 cagtacgatt tccatcaaaa gaagaaaatg cgcctaatcg atccatccat ttttcttgat 585301 gacaaatgga tcaaatcctc aggtgtttct gaaaaggtga ggaaaatggg tgaggccgct 585361 tatcaaaaag caaaaaaagg tgtgtatata aaaatcttaa agcagtaatt gccgcctgac 585421 agcggctttt tttatgtttg gctttgcaaa caaaggggaa taggacaaac tgcgggaacg 585481 ctttatgaga atatcagcgt atttacatac cgttcggggg tatagtatta tcgagagggc 585541 atgttttcat tgtctgcggg caaaagttac aggaaaaaaa tgaagcaaag gagaatgaac 585601 atgaaaatct ctaaatatgc actgggaatt ctgatgttat ctctagtttt tgttttatca 585661 gcatgcggca ataacaacag tacgaaagaa agcacacatg acaatcattc agactcctca 585721 acacatgaag agatggacca ttccggatca gctgacgttc cagagggatt acaggaatct 585781 aaaaatccga aatacaaagt aggcagccaa gtaatcatca atacttctca tatgaaaggc 585841 atgaaaggtg ctgaagctac ggtaacaggc gcctatgata caacggcgta tgttgtttct 585901 tatactccga ctaatggggg acagcgtgtg gatcatcaca aatgggtgat ccaagaagaa 585961 atcaaagatg ccggagataa aacgttacaa cccggagatc aggtgatttt agaggcttct 586021 catatgaaag gcatgaaagg agcaacagcc gagatcgatt ccgcggaaaa aacaactgta 586081 tacatggttg actacacatc gacaacgagc ggcgaaaaag tgaaaaacca caaatgggtc 586141 acagaagatg agctttcagc taaataataa aaaatcctcc ttttacaagg aggatttttt 586201 tgctgtttga acaggtcttg ttaaagaaat gaaagcaaac aggacagcga tgatcacaat 586261 cgatccgccg caccatgccg ttgacaccac agtacccgtc tgatccaaaa caacaccgcc 586321 aatggctgag ccaagggcaa ttccgacttg gagggccgat gtgttaaagc tttgctgaat 586381 gtcagacgaa tcaggtgcaa tttcaattaa atagctttgc tgagccgggg cgaggctcca 586441 gctcagaaga ccccaaatca ccatgacagg caaaaagaaa atcatagacg atgtagacag 586501 cggcagtaag aacataatga tggcaaagga accggtcacc agcaaaatgc tcttaaagga 586561 accaagccgg tcagatagcg ctcctccgaa agggcctccg catacagcag atatcccgaa 586621 aaggaaataa caaatgctga cccagaaaga gctcaggtga agagtctctt ctaaaaacgg 586681 cgcaaagtaa gcgtaaagcg tgtagtggcc agctaatgta aacatcgtga cgaggtgtga 586741 actcgcgatt ttcagattac cgatcgtctt gagttgttcc cggaaaggaa tcattttctc 586801 cgccggtatt ctttcaaaga agattgaaat aatcagcatg gagatcagtg ccaacaggcc 586861 gatgccaagg aacaaaatcc gccacccgaa ggaatcgctg attaagattc cgagcggcac 586921 gcctaatgcg atagcagagc tgaatcccat aaaaataatt ccgattgcgc gggctctgta 586981 ttcaggcgct acaattttcg gggcaattgt taaagaaagc acaacaatca gccctgtact 587041 cattgctgcc aataccctag ataccatcag tgttgcgaaa ttagggctga aataggcgac 587101 aagattgcta aggaagaaaa caaataaagc aattagatat aagcgcttcc gctcaatctt 587161 cgcagtcaat gccaaaagca gcggcccaga tactgcatat cccagcgcaa acacactgat 587221 cagctgtccg gctgaaacaa tggaaatgtc taaatcattt gcgatctgag gaagaattcc 587281 ccccacaatt aactcaacca atccgactgc aatcgtagaa gctgcaagca ggaaaacttt 587341 gaaattcata acaaactcct ttacttaaat gttttgataa ataaaaaaaa tcctgattac 587401 aaaaaatgtc ataaacaaat tttgtaatca ggattttacg gttcctggta gacaccctca 587461 aaccatatta ttgaggttat acaagtgata atagctattt aattgattcg tttccgttga 587521 tgagtgtacc acattatgaa tgaatcttcc atagaaaaat ttataaaacg gtgaaccgga 587581 aaaaaatatg attatattta ttttataaaa gtatagacat ttaaaattaa atgactataa 587641 taatcaatgt aagcgtttta ataacagggg ggatagcagt tgaaaaaaat attactcgcg 587701 tgcagttcag gaatgtctac cagtttattg gtgacaaaaa tgaaggaata cgcacagtct 587761 atcggtgagg aagcggagat ttgggctgtt ggccaggata aagcaaaaga agacatgaga 587821 aaagcggatg ccgttttgat cggtccgcaa atgagctttc tgaaaagcga gctccaaaaa 587881 gaagcagatc aatacaacat tcaagttgaa gtcattgaca tgatggccta cggaatggca 587941 gatgggaaaa aagcgtatga gcaggcattg tccttaatgg tgaatcaata atggaacaga 588001 tgaaaatcac gaatttaaca gacgagcaaa tcagttttca gctaatcctg cacagcggaa 588061 atgcccgcag ctgcatcata caatcactgc gcgcctataa agaagggaaa aaggacgagg 588121 ctgatgccct cattgccaag gcggagcagg atttatccgc ggcccatgac attcactttc 588181 aaatgataca gaaggaatcc ggcggagaag caacagcttt ttcattgctg cttatgcatg 588241 cagaggatca tctgatgtca acattatcca tgaaagaatt agtgaaagag atgcttgatc 588301 tctttaaaac caagaatata taaaaaatcg gggtggatag ggtgttcgag aaaatcagcc 588361 aattccttgt tccaattgca gggaggttaa acaataaccg ctatttgcaa gtgttgcgtg 588421 atgcatttat gctggctttc ccgctgacga tattcgggtc catttttgtc gtgttaacga 588481 atttgccgtt tctaaacaaa atcatgaacg cctcaatgct tacgtcgttt cagtctcatt 588541 tcggcattgc ctccacggcg acaatgggca ttatgtctgt ctttgttgtg ttcgggatag 588601 gctattacct gtcgaaaagc tatcaggtcg aagctgtatt tggcggagcg atcgctttgg 588661 tttccttttt gctcttaacg ccatttatca ttcagccgga aacaggtgat gccattacag 588721 gggttatccc ggtcgatcgt ctcggtgcaa aagggatgtt tcttgggatg attacggcat 588781 ttctttctgg cgaaatttac agaagaatcg ttcaaaaaaa cctgacaatc aaaatgccag 588841 ccggcgttcc gcctgctgta gcaaaatcat tcgccgcact tattccggct tttatcacat 588901 tgactgtatt tttgctgatt aacgtaatgg tgactctgtt ttttaaaaca aatatgcacg 588961 acgtcattta tcatgcgatt caggctccgc ttgtcggact tggaagcggt atcattccaa 589021 cactgattgc cgtgtttttc attcaaattc tttggttttt cggactgcat ggacagatca 589081 ttatcaactc cgtgatggac ccgatttgga atacactgca ggtagaaaac ctttctgctt 589141 acacggcggg aaaagaaatc cctcatatta tttcaaaacc gtttatggag atttatacag 589201 tagggatggg cggaacaggg atgacgcttg cgattgtgtt taccattctc atattcatga 589261 aaagcaggca gatgaagcaa gtatcaaaac ttggcctcgc tcccggtatt tttaacgtaa 589321 acgaaccgat tatctttggg cttccgattg tcatgaatcc gatcattatt gtgccttggg 589381 tgctggcacc gatggttgtt acgctcgtca cctatctggc tatgtcagcc gggctcgttc 589441 cgcctccaac tggtgtgaca gtgccgtgga cggttccatt attcattaat ggcatcatgg 589501 cgacgaactc aatcatgggg ggcgtgatgc agcttatcaa tctgctgatt gtcttcgtga 589561 tctggtttcc gttcctaaaa gcaatggata aattaaatct ggcaaaagaa aaagaacagg 589621 ctgtgcagga gacagctgct cagcaaaatg ataacagcat aaaaatgtga cataagggga 589681 gagagacttg gcacatacag aacaatatcg ttttccaaag gatttttggt ggggatcatc 589741 cgcttcagca acacaaatgg agggtgccgc cgacagagac ggaaaaggcc agaatatatg 589801 ggattattgg tttgaaaaag aaccgcatcg tttttttgat catgtcggac ccgcagacac 589861 atcccaattt tacgacaact ataaagaaga tatcaggctg atgaaggaac ttggccacaa 589921 ctcgttccgg atgtcgattt cctggtcacg tttaatacca aacggaacgg gcgagatcaa 589981 cgataaagcc gcagatttct ataacaatgt cattgatgag ctgatcgcta acggaattga 590041 accttttgtc aatttgtttc atttcgatat gccgatggcg cttcaaaaaa tcggcggctg 590101 ggtcaacaga gagacggttg acgcgtatga aaactatgca agaacttgct tccgtttgtt 590161 tggcggccgg gtgaaaaaat ggttcacgca taatgaacca atcgttcccg tagaaggcgg 590221 atacctatat gattttcatt atccaaacaa ggtcgatttt aaagaggccg tccaggttgg 590281 atttcatacg atgctatcaa gtgcccgcgc cattcaggct tacagggaga tgaagcagga 590341 cggaaaaatc ggcatcatct taaatttgac cccttcatac ccgagaagca gccatccggc 590401 ggatgtgaaa gccggggaaa tcgcagacgc gttttttaac agatcttttt tagacccatc 590461 tgtcaaaggc gaatttccca aagagctggt tgacattttg aagcatgaag gctttatgcc 590521 tgattacaac gctgaagatc tcgacatcat caaaaagaac acggttgacc tgttgggagt 590581 gaattattac cagccgagac gtgtgaaagc gaaagaacat cttccgaatc ccgacgctcc 590641 ttttttgccg gacaggtatt ttgatcccta cgtcatgccg ggccgcaaaa tgaatccgca 590701 tcgcggctgg gagatctatg aaaaaggcgt ttatgatatt ttgatcaatt taaaagaaaa 590761 ctacggcaac atcgagtgtt ttatctctga aaacggtatg ggggttgaag gtgaagagcg 590821 attcagggat gaacaaggca tcattcagga tgattaccgg attgaattta taaaagagca 590881 cctcaaatgg attcaccgcg ccatacagga aggctcgaac gtaaaaggct atcacttatg 590941 gacgttcatg gacaactggt cttggacaaa tgcctataaa aaccgatacg gatttgtatc 591001 agtcaatctt gagaaagacg gagaaagaac cgtcaaaaag agcggaaaat ggttcaaaga 591061 ggttgctgag catagcggtt tctagatttt cctaaaggtc aagatcttcc ggcaatcatc 591121 ataacgaata gagatgacga aaatccgcaa cattgatgaa atagggaaaa gaacttatga 591181 tatccgtaaa agcttatgtg atatcaaaca gctgccggag gataccaatg aataaatacg 591241 aaatcattgc aaatgaaatg agaaatagaa ttaaaaataa cgtatatccg atcgatcagc 591301 ccattcctga tgaagtatct cttgcaaaag aatttaactc aagccgcatg acgatgaaga 591361 gagccttgga taatttagtt gccgagggtc tgctgtttag aaaacgaggc catggcacgt 591421 ttattattca atctgcaata caggatgacc atgtccatgt agtcagcaat gagattctcg 591481 gattgaccaa cttgctgaaa gataaaaaaa tcaaaagcaa ggtcattcag tttgaagtgc 591541 aatttcccac tgaggaagtg gccgcccatt tgtctattga tcagaaaaca ccggtttatt 591601 atgtcgttcg gctgcgaatt gtagaaggtg aaccctatgt attagaaaaa acatatatgc 591661 cgactcattt aataccgggc attaatgacg atgtccttca tgattcgatc tacaatcata 591721 ttacaaatgt gctgcagctc aaaatcgccg gaacgcatcg gaaaatcaga gcctgcaaat 591781 ctgatcatat tgaccagcag catctgggct gtaaacagga tgatccaatt cttgaagtgg 591841 aacatgtggg cttcttagat accgggattc catttgaata ttccttttca cgtcatcggc 591901 atgacaagtt tgttgtgact tctgtaaaca tacggcgctg attgcggaga caacaaggag 591961 gccatctgca tgcttggcgg tattgaagca ggcggcacaa agtttgtttg tgctgtcggt 592021 agagaagatg gaacgatcat tgacaggata gaattcccca caaagatgcc ggatgaaacg 592081 atagagaaag taattcaata ttttagccaa ttttcattac aggcaatcgg catcggctcc 592141 tttggtcccg ttgataacga taaaaccagt caaacatacg gtaccattac ggccacgccg 592201 aaagcgggct ggagacacta tccctttttg caaaccgtta agaacgaaat gaagatccca 592261 gtcggattta gtacagatgt caacgctgcg gcgctgggtg aattcctttt cggtgaagcg 592321 aagggtcttg acagctgcct gtatataacg attggcactg gcatcggagc gggggctatt 592381 gtagagggga ggctccttca ggggctgtca cacccagaga tgggccatat ttatatccgg 592441 aggcacccgg atgacgtata ccaagggaag tgcccttatc atggagattg ctttgaaggc 592501 ttagcttcag gccccgctat cgaagcccgc tgggggaaaa aagccgcgga tttatcagat 592561 atagcacaag tctgggaact ggaagggtac tatattgccc aagcactggc tcagtatatt 592621 ttgatccttg cacctaaaaa aatcattctt ggcggcggcg tcatgcaaca gaaacaagtg 592681 ttttcttata tctatcaata tgtaccaaaa atcatgaaca gctacttaga tttttctgaa 592741 ttatcagatg atataagtga ttatattgta cctccacgtt taggcagtaa cgccggaatc 592801 atcggcacgc tagttttagc gcatcaggcc ttacaagcag aggcagcatc cggggaggtg 592861 cgatcatgac gcatccatta tttttagagc ctgtctttaa agaaagacta tggggaggga 592921 cgaagcttcg tgacgctttt ggctacgcaa taccctcaca aaaaacaggt gagtgctggg 592981 ccgtttctgc acatgcccat ggctcgtcgt ctgtaaaaaa tggcccgctg gcaggaaaga 593041 cacttgatca agtatggaaa gatcatccag agatattcgg gtttccggat ggtaaggtgt 593101 ttccgctgct ggtaaagctg ctggacgcca atatggatct ctccgtgcaa gtccatcctg 593161 atgatgatta tgcaaaactg cacgaaaatg gcgaccttgg taaaacggag tgctggtata 593221 tcattgattg caaagatgac gccgaactaa ttttgggaca tcatgcaagc acaaaggaag 593281 agttcaaaca acgaatagaa agcggtgatt ggaacgggct gctgaggcga atcaaaatca 593341 agccaggaga tttcttttat gtgccaagcg gtacactcca tgctttatgt aagggaaccc 593401 ttgtccttga aatccagcaa aactctgata caacatatcg cgtatacgat tatgaccgct 593461 gtaatgacca gggccaaaaa agaactcttc atatagaaaa agccatggaa gtcataacga 593521 taccgcatat cgataaagtg catacaccgg aagtaaaaga agttggtaac gctgagatca 593581 ttgtttatgt gcaatcagat tatttctcag tgtacaaatg gaagattagc ggccgagctg 593641 cttttccttc atatcaaacc tatttgctgg ggagtgttct gagcggatca ggacgaatca 593701 taaataatgg tattcagtat gaatgcaatg caggctcaca ctttattctg cctgcgcatt 593761 ttggagaatt tacaatagaa ggaacatgtg aattcatgat atctcatcct taatgaatgg 593821 gggagttgca tttgtttaag aaacatacga tctctttgct cattatattt ttacttgcgt 593881 ctgctgtttt agcaaaacca attgaagcgc atactgtgtc gcctgtgaat cctaatgccc 593941 agcagacaac aaaaacagtg atgaactggc ttgcgcacct gccgaaccga acggaaaaca 594001 gagtcctttc cggagcgttc ggaggttaca gccatgacac attttctatg gctgaggctg 594061 atagaatccg aagcgccacc gggcaatcgc ctgctattta tggctgcgat tatgccagag 594121 gatggcttga aacagcaaat attgaagatt caatagatgt aagctgcaac ggcgatttaa 594181 tgtcgtattg gaaaaatggc ggaattccgc aaatcagttt gcacctggcg aaccctgctt 594241 ttcagtcagg gcattttaaa acaccgatta caaatgatca gtataaaaaa atactagatt 594301 cttcaacagt agaaggaaag cggctaaatg ccatgctcag caaaattgct gacggacttc 594361 aagagttgga gaaccaaggt gtgcctgttc tgttcaggcc gctgcatgaa atgaacggcg 594421 aatggttttg gtggggactc acatcatata accaaaagga taatgaaaga atctctctat 594481 ataaacagct ctacaagaaa atctatcatt atatgaccga cacaagagga cttgatcatt 594541 tgatttgggt ttactctccc gacgccaacc gagattttaa aactgatttt tacccgggcg 594601 cgtcttacgt ggatattgtc ggattagatg cgtattttca agatgcctac tcgatcaatg 594661 gatacgatca gctaacagcg cttaataaac catttgcttt tacagaagtc ggcccgcaaa 594721 cagcaaacgg cagcttcgat tacagcctgt tcatcaatgc aataaaacaa aaatatccta 594781 aaaccattta ctttctggca tggaatgatg aatggagcgc agcagtaaac aagggtgctt 594841 cagctttata tcatgacagc tggacactca acaagggaga aatatggaat ggtgattctt 594901 taacgccaat cgttgagtga atccgtaatg tcacaattaa gaaggtgctc aagaagtttc 594961 ttgagcacct tcccactgga ttaagcattc atatcgccta acccaggact gtgttcattt 595021 ggtatttcag gaagcactgg tacgggaaac cctgccggag gatctattac ttgtaactct 595081 ccgccatttc ggcttggaga tttcccttga tagatttcac tgattctcgt ttcatccaac 595141 ctaaagttaa aatgtgtatt atggtagcct aattcgacat actttctgca ctcaggatat 595201 ttattaatgt cataattcgg cacagggagc agcttcgccc attcaacgcc caatgtctcg 595261 agcgctttcg cgaatgcatt ctggtgagca ttgtcgcgta caatcagaaa agcaagtgtt 595321 tcgcggaacg tctgattaga gctcatttca taaattcttg ttttttgcag cacacctgtc 595381 gactcaagaa gcaggttatc cagcaggtca gtaattaagt ttccgtggtt atacacccac 595441 gacccgttcc acggattgcc ccctgcatca acaggaaggg aactttgcgc tccaataata 595501 taatgatgag gattagcatg tttaaccgct tcatcaagtg gcgcttgatc tgtaccttga 595561 ctgccgacac cttcaccgcc tgattcatct aataaagcat tgattgtgtt ttgaaccagt 595621 tcaacgtggg caatctcctc taaaaaaatg ccgcgaagca gatcgcggta ctgtttctgc 595681 tttcctctga aattagagct ttggaaaaaa actgcatcat tgtacgcatt tctccgtaat 595741 gaccgcctaa tatctcctgc aggaccttag cagctgccgg gtctggcttg tccggtttaa 595801 tgatattaat cagttcctct ttgtagtaat acataacacg cctcatttct tcttaagaga 595861 ttttcttata ttatttgtaa gatgagataa aatatataca tgataagcat gggaaggcgt 595921 gaaagaagaa aataaaaaaa tacaggaaaa gtgttgacca aataaaacag gcatggtata 595981 ttattaaacg tcgctgatga acagcgtgaa acaaaacaga aaaacaaaaa agttttccta 596041 aggtgtttac aagattttaa aaatgtgtat aataagaaaa gtcgaattga aaaagattcg 596101 aaaaaacatt aaaaaacttc ttgacttcaa catcaaatga tagtatgata gttaagtcgc 596161 tcaataagcg cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg 596221 gttcgactcc tctcgggcgc gccatataag ataccacgcg ggtgtagttt agtggtaaaa 596281 cctcagcctt ccaagctgat gtcgtgagtt cgattctcat cacccgctcc attattgaat 596341 gatctttgaa aactaaacaa gacaaaacgt acctgttaat tcagtttttg aaaatcgcac 596401 agcgatgtgc gtagtcagtc aaactagggc ctgcacgatg caggtcacac aggtgtcacc 596461 gcgggatgcg gtggacttaa cctgtgatcc atttatcgga gagtttgatc ctggctcagg 596521 acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg aacagatggg agcttgctcc 596581 ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata 596641 actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa 596701 aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta 596761 atggctcacc aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac 596821 tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 596881 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 596941 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 597001 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat 597061 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 597121 accggggagg gtcattggaa actgggaaac ttgagtgcag aagaggagag tggaattcca 597181 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 597241 gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 597301 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 597361 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 597421 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 597481 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 597541 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 597601 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 597661 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 597721 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 597781 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 597841 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 597901 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 597961 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 598021 gtgcggctgg atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta 598081 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 598141 ttgaaaacta gataacagta gacatcacat tcaattagta atacaagata tcacatagtg 598201 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 598261 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 598321 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 598381 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 598441 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 598501 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 598561 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 598621 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 598681 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 598741 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 598801 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag 598861 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 598921 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 598981 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 599041 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 599101 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 599161 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 599221 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 599281 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 599341 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 599401 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 599461 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 599521 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 599581 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 599641 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 599701 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 599761 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 599821 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 599881 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 599941 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 600001 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 600061 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 600121 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 600181 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 600241 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 600301 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 600361 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 600421 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 600481 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 600541 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 600601 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 600661 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 600721 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 600781 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 600841 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 600901 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 600961 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 601021 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 601081 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 601141 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 601201 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 601261 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag cattactttt 601321 atcatcgcgg ggtggagcag ttcggtagct cgtcgggctc ataacccgaa ggtcgcaggt 601381 tcaaatcctg cccccgcaac caaatatatg gttaaataag gagtgcccta agggtgcaac 601441 caaaataatc ctatacaaat atggtccggt agttcagttg gttagaatgc ctgcctgtca 601501 cgcaggaggt cgcgggttcg agtcccgtcc ggaccgccat taatgtaaac gaaacgatca 601561 tgttttcgtt ttttttgtgt tttcttttac tgtatcttct gcttggtgtc atagccaagc 601621 tttctttata tcgggaacat cttggatatt ccagcaaaat tcgataaact aggaagagca 601681 caaataggca taagcagggt tgaaaggagg ttttggttca tggatgaatt tgatttgata 601741 catagcatta ctccgcggac cattcaccat tcttccgttg atgtaggaat aggtgatgat 601801 gcagcgctct acactgcgaa acacggcgtt caggaaattg tttgtgttga tactatggta 601861 gaagacgtgc acttcaaatt acactattcc tcacctgaag atatcgggta caaggcgtta 601921 gccgttaata taagtgatat tgccgcgatg ggaggcattc ctaagtttta tctggtatca 601981 cttgcggtac cttcaaaatg gactgaatct gaaatcaagg cgatgtatga aggaatgaat 602041 gaactggcga aactatatca tatggatctg attggcggcg atacagtttc taccgctgac 602101 aaattagtcg ttacagtcac tgtaatcggt gaaattgaaa agggacaggc ctgtttgcgc 602161 agcttggcaa aaccgaatga tattgtgttt gtaaccggtg aaatcggttc ttctgcagca 602221 gggctttctt tattgctgga agagactaat cctcaaaact catctgtgga aacggattac 602281 tttatccaca ggcataaacg gcctgagcca agagtaagcg tcggcagatt atgctcgatt 602341 tttaaacggg cagctttaaa tgatgttagt gacggattgg ctagtgaact gaacgagatt 602401 gcagaagcca gctgtgtttc aattgaaatt gttgaaagca tgcttccaat tcattctgat 602461 ttgcctaagc ttcatcctaa ctggaaagaa tgggctttgt ttggcggtga ggattttgag 602521 ctgacaggga cggtttcaaa tgaggagtgg gaagtgttga agcaggagtg cgcagcgctt 602581 catcttccca ttacaaagat tggctatgtc agggaaaaaa caaaatctaa agtgatccta 602641 aaaacagatc aaacatcaat gatcttagag aaaaagggat ataatcattt taaataagac 602701 gggtgactcg tgtgaagcaa ttaaaatgga gaactgtaaa tccagaagaa acaaaagcaa 602761 ttgccaagct gacggcagcg tttgctaaac cgggagacgt cctgacatta gagggcgatt 602821 taggtgcagg aaaaacgact tttacgaaag gttttgcaga agggctggga attacacgta 602881 ttgtaaacag tccgactttt acaattataa aagaatataa cgatggcgta cttcctcttt 602941 atcacatgga tgtgtataga atggaagatg aaagtgaaga tttgggactt gatgaatatt 603001 ttcacggaca aggtgtctgt ctcgttgaat gggctcattt aattgaagaa cagctgccac 603061 aggagcgact gcaaattgtc atcaaaagag ctggtgatga tgagcgggaa attaccttta 603121 ctgctgtcgg gaatcggtat gaaatgcttt gtgaggagtt aagtagacat gacaatatta 603181 gcaattgata catcaaatta tacattgggc attgcgctgc ttcgagaaga cactgttata 603241 gcagaataca ttacatattt gaaaaagaac cactctgtaa gagcgatgcc tgctgttcat 603301 tcattgctga atgattgtga tatggcaccg caggaccttt ctaaaattgt cgttgcaaaa 603361 ggccctggtt catacacagg agtaagaata ggtgtgacgt tggccaaaac acttgcctgg 603421 tctttagaca ttccaataag tgctgtatca agtcttgaga cgcttgcggc aaatggccgg 603481 cattttgacg gtctgatcag cccaatcttt gatgctagac ggggacaggt gtacacaggt 603541 ctgtatcaat ataaaaatgg gcttttagag caagttgttc cagatcaaaa tgtgatgctg 603601 gcagattggc tggagatgct aaaagaaaag gaccgccctg ttttgttttt aggccatgat 603661 acttctcttc acaagcagat gatcgaggat gtgcttggaa caaaaggatt cattggaact 603721 gccgcccagc ataacccgcg cccttcagaa ttggcttttc tcgggaagga aaaggaagca 603781 gctgatgttc atgggcttgt cccggattac ttgcggctgg cagaagctga agcgaaatgg 603841 attgaaagtc aaaagtaggg tgataggatg aaaacaaaag cagcggtcag aaatatgcgg 603901 cttgaagata tagatcacgt atacgaaatc gaagcatcct cctttacgtc tccttggacg 603961 aaggattcgt tttatcatga gctgctggaa aatccgtatg ctcattatct cgtgattgaa 604021 aaggacggcc atcttgctgg gtattgcggg atttggattg tgatggacga tgcccagatt 604081 acaaatatag cgataaaacc agagtatcgc ggccagtctt taggagaaac gctttttcgc 604141 tcagctgttg aactgtgcaa agaaaaagac gcaaggcggc tttcgcttga agtgagggtt 604201 tcgaatcatc ctgctcaagg cttatataag aaattcggga tgcagcccgg cggaataaga 604261 aagaactatt atactgataa cggggaagat gcgttaatta tgtgggtgac gataaatgag 604321 tgagcaaaaa gacatgtacg tattaggaat tgaaacaagc tgtgatgaga ctgctgcagc 604381 tattgtgaaa aacgggaaag agatcatttc aaacgtagta gcctctcaaa ttgaaagcca 604441 taagcgcttc ggaggcgttg ttccggaaat tgcttcaaga catcatgttg aacaaatcac 604501 tttggttata gaagaggcgt ttcgcaaagc tggcatgacg tatagtgata ttgatgcgat 604561 tgcagtaaca gaaggtccgg gactggtggg agcgcttctt atcggagtga atgccgctaa 604621 agcattgagc tttgcatata acattccgtt agtaggcgtt catcatatag ccggtcatat 604681 atacgcgaac cgtcttgtag aagacatcgt gttcccggca ctggcattgg tcgtttcagg 604741 aggccataca gaactggttt atatgaagga acatggatca tttgaagtca ttggggaaac 604801 ccttgatgat gcggcaggag aagcctacga caaagtggcg cggacgatgg gattgccata 604861 tccgggtgga ccgcaaattg acaagctagc tgaaaaaggg aatgacaata ttccgcttcc 604921 tcgcgcatgg cttgaagaag gctcttacaa cttcagcttt agcggattga agtctgcggt 604981 gatcaatacg cttcataatg catcccaaaa agggcaagag attgctccgg aagatttgtc 605041 tgccagtttc caaaatagtg tgatcgatgt cttggtaacc aaaacggcgc gcgcggcaaa 605101 ggaatatgat gtcaaacagg tccttttagc cggaggagta gctgcaaaca gaggcctcag 605161 agctgcatta gaaaaggaat ttgcccagca tgaagggatt acgcttgtca ttcctccatt 605221 agctttatgc acggataatg ctgcgatgat tgctgctgct ggtacaattg cttttgaaaa 605281 aggaattcgc ggtgcatatg atatgaatgg ccagcccggc cttgaattga cttcttatca 605341 aagtctcacg agataatagc gtgagacttt ttatctgttt gttattaaca gacaattcac 605401 aatttatcca catatctgtg agtaattata gagatattga tggataaagg gctgaggtca 605461 ctgttaataa agtggataaa ttcagaatat tttgtggata gtgtgtataa agcgcttact 605521 ttgtttattt attaggggat gttctgtgga taaaaagcac ctctaaaaag aggtgcttga 605581 cttttttaat cttcttctgt ggatagttct tcccattcgg acaaaagaga ttccagctcc 605641 tgattaagct tctcattgtc tgcatggata gcttgtactt tttcatgatc ctgatagact 605701 tcagggtcac atagcaattc atcattgcgg ctgatgttct cctcaatggt ttgaacggtg 605761 gtttcaattt cttcaatccg acggagtcgt tggcgctctt tctttttcca ttctttttct 605821 tcctcgtagg aacgtttgga gtcagacttc actgtagctg gcgttttatc agtttcctct 605881 tgctgattca ttttctccaa ttcaagctgc tctgtttttt tctctgtata ataatcgtaa 605941 tctcccagat actcctctat atggcttgaa gaaagctcca atactcttgt ggcgattctg 606001 ttaataaaat atctgtcatg tgagacaaat aacagtgtgc ctggataatc aatcagcgcg 606061 ttttcgagaa cttctttgct gtctaaatcc agatggttcg tcggttcatc aaggatgaga 606121 aagttggctt tttgaagcat cagcttagct agagccaatc ttgctttttc gcctccgctc 606181 agtgaatgaa ctggtttcag cacatcatct ccggagaata agaaatttcc gagacacgtt 606241 ctgatttctt tttctgggag cccggggtac tcgtcccaca gctcatcaag gacacgttta 606301 gaggaagtca actcagcctg ttcctggtca taatagccga cactgacatt tgagccgtaa 606361 gaaattgttc cctgatctgg ttttagggtg tctattaatg ttttcagcaa tgtcgattta 606421 cctattccgt tagggccgac aagcgcagcg ctttctcctc ttgtgagcat gaatgacact 606481 tctgttaaaa gcggcggctg gttttcatag ctgattgtga gatcctgaac acgaaggact 606541 tcatttccgc tctgttttgt aatatcaaaa tgaaagtttg cggatttttc atcgccaagc 606601 ggttttgaca tgacatccat tcgctcaagc tgctttctgc ggctttgcgc ccttttggtg 606661 gtagaggctc tcgccagatt tcgatctacg aagtcctgca gctttgcaat ctcgtcctgc 606721 tgcttttcat acattttcag atctttttca tactgcgcgg ctttttggtc gagataagcg 606781 ctgtagttgc cgtgatactt tttgctttct gctcttgata cctcgtatac ctggtttact 606841 actttgtcca aaaagtagcg gtcatgcgaa acgatgagaa tggcgcctga atagccttgt 606901 aaataatgct caagccaggt aagcgtatca atatccagat ggtttgtcgg ctcatcaaga 606961 atgagcaaat caggctgtgt taatagaagc ttacctaaag ccagtcttgt tttctggcct 607021 ccgctgaggc tttgaacctg tgtagaatcg tcaaaatggc tgaagccgag accatgcagc 607081 acagatctaa catccgcttc atattgataa ccgcctttat ctttgaattc ctgctgaaga 607141 cggtcgtagg ttttcatgat gctttctaat tcacccgggt cagctgccgc cattttttct 607201 tccatagccc gcatttcctt ttccattgct tttaagtggt caaaaacagt cagcagctct 607261 tcttttatgg taagcttaga atccaagcca gtatgctggg cgagatatcc cattgtaata 607321 tctttcggtt taataatttc gcccttttca tacgaaagct ggcctgcgat aattttaagg 607381 agcgtggatt ttccggcgcc atttcttcct acaatggcga tgcgatcacg atttctgact 607441 tccagcttta tattgtttaa aatagtatca gcaccaaatg atttggacag ctgattaact 607501 tgtaagatca tcatattatt tcacctctgc tataataagt taagtgtagc ttatgaacca 607561 gaagtcagca aacaatacat tggccatata agacatagag aagaaaatag tgtatgatct 607621 gtttaaggag cgttttaata tgaatggatt ttctcatttt aatgaacagg gcagagccca 607681 gatggtggat attagcgaaa aatcttcgac tgtccgtact gcggcggctg tttcaagcgt 607741 acacatgaag aatgaagtgt acgagaaaat acaaagtcac gatatcggca aaggagatgt 607801 actggctgtc gcacaggtgg caggcattat ggccgcaaag caaacgtcga atatcattcc 607861 gatgtgccat ccgctttcat tgagcggggt agatatatcg tttgactgga aaataaaaga 607921 agcagaagtt atacttcata taaaagcaca ggtcaaaacg aaagggagta caggtgtgga 607981 aatggaagcg ctcacttctg catcggtgtg cgctcttacc gtttacgata tgtgcaaggc 608041 ccttgataag ggaatggtca tcggccctac tttcttgctg gagaagacag gcgggaaaaa 608101 cggtgacttt aaaagagaac tatccgagta taatttggag gaccaaaaat gaataaggat 608161 caatcaaaaa ttccgcaggc gacggcgaaa cggctgccgc tttactatcg ctttttaaag 608221 aatctgcatg cgtcaggaaa acagcgtgta tcatccgctg aactcagtga tgccgtaaag 608281 gttgattctg ccacgattcg gagggatttt tcctattttg gagctcttgg caaaaaagga 608341 tacggatata atgtggatta tttgctgtct tttttccgga aaacgcttga tcaggatgag 608401 atgacagacg tcatcttgat tggtgtcggg aacttgggaa cggcatttct tcactataat 608461 ttcacaaaaa acaataacac aaaaatttct atggcttttg atataaatga gagtaaaata 608521 ggaactgagg taggcggcgt gcccgtctat aaccttgatg accttgaaca acacgtaaaa 608581 gatgaatcag ttgccattct tacagtgcca gcagttgccg ctcaatccat tacagacaga 608641 ttggtcgcat taggaatcaa gggaatcctt aattttacgc cggcccgttt gaatgtgccg 608701 gaacacattc gaattcatca tatagattta gcagttgagc ttcagtcact ggtttatttt 608761 ttgaagcatt attcagtttt agaggaaatc gaatagaggg aaaggaggag cccaaatatg 608821 ccgatcggtc ctggaagcct tgctgttatc gcaatcgttg ctctgattat cttcggtccc 608881 aaaaagctgc ctgaattggg gaaagcagcg ggagacacac ttcgtgaatt taaaaacgct 608941 actaaaggat taacgagtga tgaagaggaa aaaaagaaag aagatcagta agttaggatg 609001 acacgaatga aagtgaatca aatgtcgctg ctggagcata ttgctgagct tcgaaaacgg 609061 ttgctgattg tagcgctggc gtttgtcgtt ttctttattg ctggattttt tttagcaaag 609121 ccgattattg tgtatctgca agaaacagat gaagcgaagc agcttacgct taacgcgttt 609181 aacctgacag acccgcttta tgtgtttatg caatttgcgt ttatcatcgg catagtcttg 609241 acctcgccgg ttattcttta tcagctttgg gcttttgtga gcccgggcct ctatgagaaa 609301 gagcgcaaag taacgctcag ctacattccg gtctctattt tgctgttttt agcgggctta 609361 tctttttcat attatatttt atttcctttt gttgttgatt ttatgaagcg gatttctcag 609421 gacttgaatg tcaatcaggt gatcggaatt aatgaatatt ttcattttct tctgcagctg 609481 acgattccgt ttggactgct gttccaaatg ccggtcatcc tcatgttttt gacaaggctc 609541 ggaattgtga caccgatgtt cttggcgaaa atcagaaagt atgcgtattt tacgctgctg 609601 gtgatcgcag ccctgattac accgcctgag cttctgtccc atatgatggt cacagtcccg 609661 cttttgattt tatatgaaat cagtatcctt atatcgaagg ccgcttatcg gaaagcacag 609721 aaaagcagtg ctgccgatcg ggacgtgtct tctgggcaat aataaaaaat ccatttctca 609781 tgcgagaaat ggattttctt tatttttggt tctttttgat tttaaatgaa aaggcgaaca 609841 tcttaaaaga aatgctgatg ttgtaagcgg cgaacaccat cagcaggatg gagtaaaatg 609901 accacatgct gcctggcgag cttgcggcaa gataagtaaa gatgcaccct acggcaaagt 609961 agatcattcc ccaaactacc gggtttctca taaaaataat cctccaataa tcaattgcat 610021 ttgtgtgctc tgctgttcaa ggtaattacg aacaggctca agctgcatga tgacgacgaa 610081 tgtattcatc attaaatggg cgaaaatcgg cacccatatc cgttttgttc tcgcatataa 610141 aaaggcaaag gtaaagccca ttgctgtata tagaaggaga tgcttcaaat cagcgtgaac 610201 aataccgaag ataaccgagc tgatcagtcc tgcgaaaaag aaattcgttt tttcgtacag 610261 cgcgccgaaa atgatttttc tgaagatgat ttcttctaat ataggcccga cgatggaaga 610321 aacgataatc atgagcggga ctgcctgaat gacatccaga atcgcttgtg tattttctga 610381 ttctcttccg atgccaaaaa cataatattc aatagagcct gctattcctt gagagaaaag 610441 ggcaatgaaa aaaccggcta tcgcccaaag gatagaaagt ccgattgagt ccttctgtcc 610501 gtttcgcagc gtttctttcg gaacggttct cagaatgagc agaacaacaa cgagacaggc 610561 gataaagctg ataacggacc ataatccttg tgcatgcagc atattttcat ctgtaggctg 610621 tcctccggca taaccgaatt taaataacaa gggaatcgcg attaatgcgg aaaactgcat 610681 gatgatatat gtcaaaataa taaaccaata ctgttttctc aaatggtatg tactcctttg 610741 ttaagtgggt ttcgttcatc tacagctatt gtaacataat cggtacgggg gtgaaaaagc 610801 taacggaaaa gggagcggaa aagaatgatg taagcgtgaa aaatttttta tcttatcact 610861 tgaaattgga agggagattc tttattataa gaattgtgtt agcactcttt agtgctgagt 610921 gctaaaatta catattcata ctattgagga ggttatttca ttgttaaagc cattaggtga 610981 tcgcgttgtc attgaactcg tagaatctga agaaaaaact gccagcggaa ttgtgttgcc 611041 ggattctgca aaagaaaaac cgcaagaagg caaaatcgtg gcagctggtt caggtcgcgt 611101 gttagaaagc ggagagcgcg ttgctttaga agtaaaagag ggcgaccgca ttatcttctc 611161 aaaatacgca ggtactgaag tgaaatacga aggtactgaa tacttaatct tacgtgaaag 611221 cgacatttta gctgttatcg gctaattctt aaataaacaa tacttaaaac atttgaggag 611281 gtcttgtaaa catggcaaaa gaaattaagt ttagtgaaga agctcgccgc gcaatgcttc 611341 gcggtgtcga tgcacttgct gatgctgtta aagtaacttt aggaccaaaa ggacgcaacg 611401 tggttctaga gaaaaaattc ggttctccgt taatcacaaa tgacggtgta acaatcgcta 611461 aagaaatcga gctagaagac gcgtttgaaa acatgggtgc taagcttgtt gctgaagtag 611521 ccagcaaaac aaacgacgtt gccggtgacg gtacaacaac tgcaacagtt cttgcgcaag 611581 caatgatccg tgaaggcctt aaaaacgtaa cagcaggcgc taaccctgta ggcgtgcgta 611641 aagggatgga acaagctgta gcggttgcga tcgaaaactt aaaagaaatt tctaagccaa 611701 tcgaaggcaa agagtctatc gctcaggttg ctgcgatctc tgctgctgat gaggaagtcg 611761 gaagccttat cgctgaagca atggagcgcg taggaaacga cggcgttatc acaatcgaag 611821 agtctaaagg cttcacaact gagcttgaag ttgttgaagg tatgcaattc gaccgcggat 611881 atgcgtctcc ttacatggta actgactctg ataagatgga agcggttctt gacaatcctt 611941 acatcttaat cacagacaaa aaaatcacaa acattcaaga aatccttcct gtgcttgagc 612001 aggttgttca gcaaggcaaa ccattgcttc tgatcgctga ggatgttgaa ggcgaagcac 612061 ttgctacact tgttgtgaac aaacttcgcg gcacattcaa cgcagtggct gttaaagctc 612121 ctggtttcgg tgatcgccgt aaagcaatgc ttgaagacat cgctgtcctt actggcggag 612181 aagtcatcac agaagatctt ggccttgacc tgaaatctac tcaaatcgct caattgggac 612241 gcgcttctaa agttgtcgtt actaaagaaa acacaacaat cgttgaaggc gctggcgaaa 612301 cagacaaaat ttctgcccgt gtgactcaaa tccgcgctca agtggaagaa acaacttctg 612361 aattcgacag agaaaaatta caagagcgtc ttgctaaact tgctggcggc gtagctgtca 612421 tcaaagtcgg cgctgcgact gaaactgagc tgaaagagcg taaacttcgc atcgaagacg 612481 ccttgaactc aactcgcgca gctgttgaag aaggcatcgt atccggtggt ggtacagcgc 612541 ttgtaaacgt atataacaaa gtcgctgcag ttgaagctga aggcgatgct caaacaggta 612601 tcaacatcgt gcttcgcgcg cttgaagagc caatccgtca aatcgcacac aacgctggcc 612661 ttgaaggatc tgtcatcgtt gagcgcctca aaaacgaaga aatcggcgta ggcttcaacg 612721 ctgcaactgg cgaatgggta aacatgatcg aaaaaggtat cgttgaccca acaaaagtta 612781 cacgctcagc tcttcaaaac gctgcgtctg tagctgcaat gttcttaaca acagaagctg 612841 ttgtcgctga caagccagaa gaaaacggtg gcggcgcagg aatgcctgat atgggcggca 612901 tgggcggtat gggtggaatg atgtaataaa gggatattaa cccttataca tcaatgtttt 612961 aaccgtctta aaaaactaga caaagcgtga ataaaaaaag agaaggtctt tcatcagttt 613021 actaaactgt tgggagacct tttctccata ttagcggtca tatgagcata aatgtccatc 613081 gtcgtattta tgtccgaatg accaaattgt tgctggattt ctttaatgcc tactcctgcc 613141 tcaattagta aggaggtatg ggtatgccta aaagagtggg gggtgacatt ctttttatcc 613201 cagctttttt gagcagccgt ttaagtctag tctcaataac ctttcttaat tgcggatgac 613261 catcctcccg ctcaaaaata aatgatgagt cttgataaat caatctattt ttaagcttaa 613321 tttcattttg ataaatttta ttttttttta gtagattgac atcgtttcat caattcgaac 613381 gatatcaaca gatcctgttg ttttaggtgt tagcaattgg tatttttcaa tttgattgtt 613441 aggggtgtat agggtctttg tgacctggct tatcattgaa atctgtccat tttaaagcaa 613501 gaagttcacc aattcttagg tcggtctagg caagtacggt aaagaccaaa tggtccattt 613561 ctagcccgtc agattgagcg agctttagaa aatgtgtcag cacctctttt tccaatgctt 613621 tgttgcttct tgggtaattg aaaatcccca gttgggttca ttttaataat cccttgagtt 613681 ttagcttttc ggaaaatcat acggccgcag gcatgaatac ctcccaaaca attgtgactg 613741 tattgctcgt tcagttctaa cgtgcggtct tcatacattt ttttgtgttt tgctaatcgg 613801 gtattgaccc aatactgcga taaaatgcat cattttcttt tcactggccc gtacactgct 613861 tatttttacc ccactccggt tgtaaatctt aagccaacct tttgcaaatg ttttgaaggg 613921 catatctgac tccttaataa aagtcccgtt gtcgttttgg agttctacgt gacgggctgc 613981 tactggggct tctttctttg ttttaaatct tcctttggat atttctagac gttttttggt 614041 taaagggtca atgcctagta gatatgataa ctccacgtct taccgcattg cttgagtttt 614101 gccatttatt tgtccctaac taattttttt tcatcaaatt ggtctttaag tgagtttaat 614161 aatttttgtt tctctcgact ggtcaataat tgcccttcat atttcaaaag attggataaa 614221 tttgagatgg aatcaatcct gatggatggt accgtagact ttaataagaa acgaaaggcc 614281 aactgcgact tcagttggcc tttcctattt ataataaaga aattgagtga gattgctgac 614341 agaactacgt actactcgtt ttctttagtt gcccttgcta atcgttcaac ctctccccga 614401 atcccaatcg caggctccca cgaatcaatc aaacgaatcg ccttctgatt agattccacc 614461 gctttcgttt tctctccttt acgatacaac agctgcgcca ttccgtagtg atagtagatc 614521 agttcaactt gattggcgtt atgtttgtca tagagcattt gctcaaaggc ttcttccgct 614581 ttttcaaact gatcacattt cacgtaagcg acacccagat tgaaataggc ttctatcgtt 614641 ttttcgccgc cgtatgtgga gctgatttca tttgccgctt cgtataattg aatggcttct 614701 acatgataac ctctcgcaaa gcttaagtca ccgcgaacca atagaactct gtgttgaatg 614761 gtaggggaaa tcggttgatt ttcgatttcg tttaaaattg tctctgcttt ttcctgttgc 614821 ccgtctttta aaaacagcct tgctttgagt gcatgtcccc aaacctttag atcataggca 614881 tcgtgagcgt ctgattgttc aagaatcttc agcccggctt ctatttgctg aagcgctccg 614941 tctaaatcat tgacttccat caatgcccag cctgaggtgt cgattcggaa gtacgcttct 615001 cgtgtgtgtt ggcctaagtg atgggcggcg tcggccgctt tgcgtccgta ttcgattcgc 615061 aggggcaggt tgattctgct tagaaaatgg ctaatgcggg tgatgagttc gattaggatt 615121 tctttttgtt cagtttcact tgcccattgg atgaccttta agatgtttgg ccattcttgt 615181 ttcatttgat ctaagttccg tcccagcagg tagctccaat agatagagtt gggctgttcc 615241 cgctttaaat gggtttcggc ataatcaata taatagtgcg cccagcgatt gcgggcttct 615301 ttttcatatt cgtgctgttc ggacaagtgc tgttctccgt aagcgacaac ggtttggtgc 615361 gctaagtatt gtgtcctgcc ttggcttcgt tccggctgaa tcagcgcata tgaccgcatt 615421 tgttccatag cgtaatgaaa acggcgggcg tctaatccgg ctgctgccgc caggcttttt 615481 tcatcaggcg gcttgctgaa aaagcaaagc gtctgccaga gctttcgcgt atcttcattg 615541 catctatccc aggtgcggcc aaagaggaat tcaaacaatt ccagcagtga gtagcctgct 615601 tttccaagct catgaatcag ctgctgagcg gggatgtcat cgtctgacat ataggcaatg 615661 ctgagtgcca tggctttcgg gtttccggca gtcgctgaaa tgaattcgtt tttcaggtca 615721 gatgatagat gtaacagctg ctccagcttt tcccgtttac gtgggaggtt gcatgtttgt 615781 aagcagtgat gcacttcttg ttgaaaaaat tcgtgggcat ctgtttggtc aagaccgctt 615841 agctgaatgg ctgtcatttc tccgaagctt tcccgataag tttgctttac gttttcccgc 615901 gctgtaagga gaacttttac gccttgcgga aggctggtga taaattcatg aatgtcacgt 615961 tctgcagtat caatgctgtc aacgatcagc aggatcggtt tttctctagt gtaattggct 616021 aacgcattgc ggacgacaaa ccgttttaca ttgattgatt tatcgatttg ttctttgcgt 616081 ccgagctgat aggcgatcgt atttaaaaaa tcgctaaagc ttaatccttt ccaatcagcg 616141 ctgacccaga tgatgctgtt gaatgccggc caaactgaag tatcgtcgac acaggaatag 616201 gcggcttcaa gagcaattgt ggtttttccc atgccggccc agccggtgat taaacagact 616261 ggtgatggag aaagcatcca ttgccgtatc gcttccatat caaagctgcg tccgataaag 616321 cgtccggacc agcgtgaggg taaattatgc gtgatgggct gttctgtaag cgcattcgtt 616381 tcttggccgg gtctgtcatg aaacagccgt tttactacat tttcaatttc gccttcactc 616441 ggagccccga ataatccgtc ttttcgcagt attttcgctt ttttcaaaca ggatgctgcc 616501 catacaggca atgcgggttt gatgactggg atagtggtgg cttccagcaa gtcggtcaac 616561 cactcgatat ccaagtcggt cttttcgaga atgatccaga tcattccgaa cagttttccg 616621 tcgtcgattc ttccgggaat gtagtttgcc cccatctgtc cgatccagct tttgatcgtg 616681 tttggggaga ctcccagctg gagtgcgatt ttatctatgt aagactgtcc tgttttttca 616741 ttctttttcc ttctgacttt ataatcagga tgaagtttta gcgttttgac gccaggtgcc 616801 agcatttgtg caaattgttt tcggttttca agttcagcca taagcctgca cctcctatta 616861 gtactatttt atcaatccag cgttttttgt atatgaaaaa ataaaagtac agtgccgctg 616921 tccttttata cagcaggaaa ggctgttgaa cgtgttaaaa agcagataaa atgggggcag 616981 taacagagaa aacaaaaatg tatgcactta cattttattt tctaaagaaa ggaacttgcc 617041 aaatgactca cacagtacct caaaacatga aagcggctgt tatgcacaac acaagagaga 617101 tcaaaattga aacattgcct gtgcctgata tcaatcatga tgaagtgttg attaaggtga 617161 tggctgtcgg aatttgcgga tctgatctgc attactatac aaatggccga ataggcaact 617221 atgttgtgga aaaaccattt atccttgggc atgaatgtgc gggtgaaatt gccgctgtcg 617281 gatcatctgt cgatcaattc aaggtgggag accgcgtcgc tgtagagccg ggtgttacgt 617341 gcggacgctg tgaggcgtgc aaagaaggac gctataatct ttgcccggat gtacagtttt 617401 tggctacacc gccggtagac ggtgcgtttg tccaatatat taaaatgcgt caggactttg 617461 tttttttaat cccagactca ctttcttatg aagaagctgc tttgatcgag ccgttttctg 617521 tcggtatcca tgcggcggcc agaacgaagc tacagcccgg atcaacgatt gcgattatgg 617581 ggatgggccc tgttgggtta atggctgttg ccgcagctaa agcatttggg gcaggcacaa 617641 tcattgtcac cgacttagag ccgctgcggt tagaagctgc gaaaaaaatg ggagcgactc 617701 acattattaa tatacgtgaa caggatgcac ttgaagagat taaaacgatc acgaatgata 617761 gaggcgttga tgttgcttgg gaaacagcag ggaatccagc ggcattgcaa tccgcactgg 617821 cttctgtgcg ccggggcgga aaattggcga ttgtcggttt gccttcacag aacgagattc 617881 cgctcaacgt gccgtttatt gcggataatg agattgatat ttacgggatc ttccgttatg 617941 ccaatacgta tccaaaggga atcgaatttc ttgcttcagg cattgtggac acgaagcatc 618001 tagtaacgga ccaatattcg ctggagcaga cgcaagatgc gatggagcgg gcgcttcaat 618061 ttaagaatga atgtttaaaa gtgatggtgt atccaaatcg ctgagtgaac agggaggatc 618121 ttcgtattct ccctcttgtt tactggaaat gaaaacggat tcttggggtg ggaaatgatg 618181 attggaacag aaaaagtaac ggcattgaag gcgaagcatc agtcaaaatc cagcaccggc 618241 ctgtcctggt ttgaacgaat cggttatgga ttcggcgata tgtcgtataa tattatcttt 618301 cagtttgtaa acgcatactt attattttat tatacagacg tcggcggcat tcagcctgcg 618361 gtaatcgcaa ctttgtttct tgttgtgcgt gtgctggatg ctatttttga cccgatcatg 618421 ggattgattt tagataaaac gaatacaagg tggggaaaag caaggccata tttgctgtgg 618481 gtggcatttc cttttgcgct attcacattc ttatgtttca cgacgcctca tttcggtgag 618541 accggaaata tggtatatgc gtatgtcact tatattctgc ttgggatgtc ctttagtatg 618601 caaacgatcc cggtgaacag cttaacgggg cggatgacga attcggtgga ggaacgaacg 618661 gttctgacca caacccggat gattttggtg tatatcggca ttcttttatc catttcctgt 618721 gcgacaccgc ttgcaactgc tatcggagga gaggatcagg cgtttggatt tcagatgacg 618781 gcgctcatct atgcggctgt cagcatcgtt ttgaatctat ttagtttctt tactgtacgg 618841 gagcggattc agcctaaaaa gagaaaaaaa caagggatca aaaagacgtt atccgtttta 618901 ttcaaaaaca aacccttgct catgttaatt tcatcatttt tggcttttgc gatcgggttt 618961 aatattaagc tcagcacgat ggtgtattat tttacgtata acgtaaacca taaagagttc 619021 gtgtttatgg gcaccgtttt atttttcggg gcagcgctga tcagcaattt gtttattcct 619081 ttcttttctg agaagtgggg cagaaaacaa gtcatgatta tcacggcagc tctatcgctt 619141 atttcttatg ccggcctgca ttttacgccg tattcttcaa ttccactcat tttcatttgg 619201 cttttcgctt cgggattttt cacaacgcct ttaaatacgc ttgcttgggg aatggttgcg 619261 gattgcgtcg attatgcgga atggaaaacc ggaattcgcg cggatggtgt tgtgatttcg 619321 agcatgagct ttattaataa gctgggtgtt gcgttagccg ggtcattttc ggccatttat 619381 ttaggaatcg ccgggtatgt ggcgaataca gaccagacag ttgcgtcgtt gaatgcgatt 619441 aaaaatatga atgctttgat tccgggattt ttcattttgc tttctattat tcttatcgcc 619501 ttctatcctt taacggaaaa aagatataaa cacatcatct ctgagctgga gcaaaggtct 619561 gcgagataaa tagatgtaaa atttttaata ttcaatgttg tatttatggc aaaaagtaat 619621 atactgagac tgtaatctag actttataaa tgagtgtgat aatatgcgta gtcattctgt 619681 agtttgtatt ggggaattgt tgattgattt cttttgtacc gatgttgacg ttgatttaat 619741 ggaagggcgc caattcctga aaagtgccgg cggggcaccg gcgaatgtgt cggcagcgat 619801 tgccaagctg ggcggagacg ccgctttcag cggaaaagta ggaaaggatc cgtttgggta 619861 ttttctgaag cgaacattgg acgctgtaca tgtcgatacc tctatgctgg tgatggatga 619921 gaaagcgcct acaacgcttg cttttgtttc attaaaacaa aatggagagc gtgactttgt 619981 ttttaataga ggcgcggacg ctttgtttac gctggaggac attgaccagg aaaaactaaa 620041 cgaagcgaaa atccttcatt tcggctctgc gacggcactg ttatcggatc cgttttgctc 620101 agcctattta cggttgatgt cgattgcgaa agacaatgga cagtttattt cgtttgaccc 620161 taactaccgt gaagatttat ggaggggaag agtctcagag tttgtaagtg ttgcgaaaaa 620221 agcgatcgct gtaagtgatt ttgtgaaagt cagtgacgag gaacttgaga ttatcagcgg 620281 tgtgaaggat catgaaaagg gagttgcgat ccttcatgag atcggagcca acattgtcgc 620341 tgtgacactt gggaaaagcg gaacgcttct ttccaatgga aaagaccgtg aaatcattcc 620401 aagcattccg gtgacatcaa ttgactcaac aggggcggga gatgcttttg tcggtgcggc 620461 tttatatcaa ttggcaaaca cggatcagat tcaatctgta gatgctgatt ttgtgaaact 620521 gcgtgagatt gtggcgtttg ccaataaggt cggagctctt gtgtgcacta aaattggagc 620581 gattgatgca ctgccgagtt tggatgagat tggagtttct ttgtaaatca ttgaagatgt 620641 ttcttgaaag tctttggact tttgggggca tcttttttta ttgcttacat ttttgttcag 620701 gtaaaaagtt gtatattttt tgtttgaaat gtcatttttt attaaaaaag tgaaactttt 620761 aacgataata aatagtatat gtaacaaggg ttaccgaatt agctttagga ggaacgatat 620821 aatgagtata attggaagat ttaaagatat tatgtctgcg aatatcaatg ctttattgga 620881 caaggctgaa aatccggaga aaatggtaga tcaatattta agaaatatga atagcgattt 620941 ggctaaggtt aaggcagaaa cagcagctgt tatggctgag gagcagagag caaaaagaga 621001 atatcacgaa tgccaggcgg atatggaaaa gatggaaagc tatgcaatga aggcgctgca 621061 agccgggaat gagagcgatg cgagaaaatt tcttgaaaga aaaacatctt tggagtcaaa 621121 gctttctgag ctgcaggcgg cgaatcaaat tgctgcaacc aatgccgcac agatgagaaa 621181 gatgcatgac aaattggtat ctgacattgg agagctggaa gcacgcaaaa atatgatcaa 621241 ggcgaagtgg gcagtagcga aaacgcaaga aagaatgaac aaactgggcg cttctgtttc 621301 aagtacaagc caatcaatgt ctgcattcgg ccgaatggag gacaaagtaa ataaggcact 621361 tgatcaggcc aatgcaatgg ctgaactgaa cagcgctccg caggatgata tggctgatct 621421 gtctgcaaag tatgacactg gcggttcaag ccaggttgat gatgaacttg cggcgttaaa 621481 agcgaaaatg atgctcgata agtaatacat aggaggccgc agctttcggc tgcggcgtca 621541 ttttatcata aaatgtgaga gggaacggta atgataatat cttataagtg tccgaactgc 621601 ggcagtgata tggcatttga cagtgaaacc ggctcgttat cctgcagcag ctgcggaaga 621661 caggacaata ttgaaagcct tccgaaagaa aacattgcgg cacggttttc tgatgatgaa 621721 gcaaaagaat atcaatgtaa aaactgcggt gccgttttga tcacggaagc tgaaacgaca 621781 gcaacgacgt gcagcttctg cggaggtgct gcaatacttg ccgatcgttt atcaggacat 621841 ttggcgccgg cgaaggtcat tccatttaca atcagcaagc aagaagcgga gcaggcattt 621901 cgaaagtggt gcaaaaaagg ccttctgaca ccaagaggtt tcatgtctgc tgatcgtatc 621961 aaaagcatca ccggcatgta tattccattt tggatgtttg atttaaatag tgaagtacag 622021 gtgagagcaa actgtaccag agtccatcaa tatgaagaag gggattatat ttgcacggaa 622081 acagagcact ttgaagcgtt tcgtgatatc aatctcgatt atttgaaaat ccctgtcgat 622141 gcctctgaaa aaatgaaaga cgaattaatg gacaaattgg agccttattc atacgaagag 622201 ctgaaggact ttcaaacggc atatttggcc ggttatattg cggaaaagta caattatacc 622261 gatgaggagc tttttccgag ggcaaaagag aaaatcagca gttatataga ttcatacatc 622321 cattctactt tttccggata tacgtcagtc aatgtgaggg acaaacatat tcacacgaaa 622381 aacgtgaaca gcttttacgt tttgcttcct gtttggatgg tcagttacga ttatgaaaga 622441 gcggagcata tctttgcgat gaacgggcaa acaggaaagg tcgttggaaa gccgccgatc 622501 agtcgaggaa aagtggctgc atggtttagc ggaatagcag gcgggacatt tcttgcgttg 622561 aagctcgtct cattgatgat gggaggcgga ttttgatgcg tggatttttt gggaaagcga 622621 tctttgttgt gctggctgtt ttcatcatga tgcctttact gggtatcgaa gcggtaagag 622681 cctctgaatt gcagcagcat gtgtacgatc gcgctcatct attgtcaaaa gcggagatcg 622741 gaaaacttga atctctctcg gcaaagctgg gtgcaaagag ggacactgat ttcatcatta 622801 ttacgaccaa aagcacaaac ggtgaagata ttgcagacta taccggcgat ttttatgatc 622861 gttacggaaa aggcagtaca gccattctga cgattgatat gacaaacaga gaagtgttta 622921 tcgcaggctt taaaaaagcc gaacagtatt tggacaacag caggctcaat agcatcagaa 622981 atacgatttc atctgattta tccaatgaaa attattttga agcttttgag acatatattc 623041 agctttccta taaagatatg ggcataaaac cgggagtaaa ccctgacaac atattcttta 623101 catggtggtt tcagctgatt gctgccatcg cagtcggggg aattgcggtt tcaatcatgc 623161 tttatcatgc aggcggcaaa gtaacggtta atggaagtac atatatggat cagcgtacgt 623221 ctgatgtgat tgatcaatac gacacttata ttagaacgac tgtaacaaga gaaagaaaac 623281 catcagataa agacagcggc agcgatggcg gtgttacgaa aggcggcacg tcatacagtg 623341 ggagccgggg cagtttttaa atgtaagaaa tagagaaagg gagaggcgta atgtcgtttt 623401 tcagaaatca attagcgaat gtagtagagt gggaagaatt tagagatgat atgatttttt 623461 ataaatggaa caatcgtgaa atcaaaaaag ggagccgttt aatcattcgt cccggacagg 623521 atgctgtctt tttgaacaat gggcgggttg aaggagtctt tcaagatgat ggcgattatg 623581 atattgaatc agaaattatt ccattccttt caacgttaaa gggctttaag tttggcttta 623641 acagcggcat gcgagctgag gtgctgtttg tcaatacgaa ggaatttacc gtaagatggg 623701 gaacaaaaca ggcgataaat attccggcag cgggaatgcc aggcgggatg cccattcgcg 623761 caaacggcac atttaatttc aaggtgcagg actatatcag cctgattgat aaaatcgctg 623821 gcgtgaaaga tcaatatttt gtagaggata ttaaaacccg tatcatttct attctggatc 623881 agcttctcat gaagtggatc acaagagaag ggaaagatat gtttaatctt caagcaaacg 623941 cttttgatat tgccaaggga attcaagagg acttagatat gcaattaata agcgacggga 624001 tgacggtcac tggttttcaa atcatgagct ttaattatcc tcaagaggtt caagatatga 624061 ttacaaagaa cgcttcctac ggtatggttg gggatgtgaa cagataccag caaatatcaa 624121 tgacggatgg aatggcatcc ggaaagatga gcggaagcgg agcggcttcg gatatggctg 624181 gaatgatgat gggaatgaat atggccaatc agatgatgaa ccaaatgaat cagaatcagc 624241 aggcacagtc atcaggccca cagtcaactg gcagcggaag caaaccgaat ttctgtccaa 624301 actgcggaac aaaaacgggc gaagccaatt tttgtccgaa ttgcggccag aagcttgtat 624361 aagaatcata cagtgaaaag tccggagtga tcagcactcg ggactttttt atttaggaga 624421 ataagcatta cctattgctt gctcctgaac aggccatttt cgagcccccg cttggataat 624481 tcccagcagc aattgacgac gttcctttat tgaattgacg gcaatttgaa atgtttgctt 624541 tgataaagcc ggtatgcctg attgttgaag ctttgagatg tctggttctg gcggcgcttg 624601 ttctgcagga tggatatagg cagtatgaac ggtatccaga tagtttttga tacttgagcg 624661 cgcttctttg atatgaagct gattcggctg atattgttca ggaattccgt atttgaaaat 624721 ggttagagcc tcatccaata cagcaacagc tataatggat gattcctgat gctgcgtgct 624781 gtggtaaaaa tgaaggatgg ggaaggcgtt atgctgagcg gtcagctttc ccagttctga 624841 tgaggcagcg acaagaagaa aatcaatgtc gtgaaaatct ttgccattcc atgcattatg 624901 gacgatttca gttccgtcat gccctagact taatacactt tgggcaaagg agcgtttttg 624961 attaaccgca ctcaagacgg aaatcaaata cgtgacagaa aatgtgatgg taagcagtcc 625021 ttgagctgtt tcaataatcg tgacaagctt ccataggcct ccgttcggag cgaggtcgcc 625081 atttcctaat gtaaacatga catagccgga aaaataaatt cggtctgacc aggaagccgg 625141 ttcttttgat tgagtttcca taagtgagtg agggtcactc gagtaaatca aaacccaccc 625201 gctccaaaat agactgatcc atatcactaa cgtcaggcat aacagcagag gaccagccat 625261 acttagaacc tttgcgtggt caccgctgat tttgcggcag cccttccaca gccaggcaga 625321 caggcatctt gtgatcgggc cggcaccgct ctctaaccat aacgtggtcc ataaaaaatc 625381 aatcatcccc gctgtcaata ataaaaggcc tgcaatgata taaccctcat tcattttggt 625441 tgcctccctt aagtcagcct tcttttattt tcttctctat ttccttttat cctgagtctg 625501 aaacaattga acgaatgttt gattttacag agaaaaatag gtgggagtta cccaacactt 625561 actcattttt caatatgaac agaaaatcac aagatttttg acttgattca cacattttca 625621 tgaagaaaaa cgttcatttt ccccttgaat tggtgatttt ccttttatag agtaaaaaat 625681 tttcagaaat ttatattgac tgaaagcgtt tttataatta tgataatatc agatataaca 625741 aaaatgtcac tataacatca ctacaattga actattaagt gactaataaa taccaaatga 625801 acgaggttat gcacaaagaa atgaccattg ttcttttaac gagaaatgaa atcgcttcca 625861 tagggattga catgctaaga agaagggaag gttatgaggt tattggataa aaacatgaac 625921 aactattttc tgaagcctgc ttacgaaatg tgaggaaggc agcagccctg gaataagttt 625981 ttgacatacg cattttgaaa aagactgggg gaaacagtat gaataaacaa ggaaatcaaa 626041 tgtcattttt acgtacaatt attttagtct ccactttcgg cgggcttctt tttggctatg 626101 ataccggtgt gctcaatgga gctttgccgt atatgggaga gccggatcag cttaatctca 626161 atgccttcac agaaggcctt gtcaccagtt cacttctttt tggagcggca ctgggtgctg 626221 tgtttggcgg caggatgtct gattttaacg gccgccgcaa aaatattttg ttcctcgctg 626281 ttatattttt tatttcaacg attgggtgta cgtttgcacc aaatgttacg gtcatgatta 626341 tttcccgttt tgtgctcggt attgcggttg ggggtgcatc cgtaacggtg cctgcctatt 626401 tagcagagat gtctcctgtg gaaagcaggg gacggatggt gacgcagaac gaattgatga 626461 ttgtatcagg acagcttttg gcctttgttt ttaatgcgat ccttggaaca acaatgggag 626521 acaactccca tgtgtggagg tttatgctgg tcattgcgtc acttccagcc ttgttcctgt 626581 ttttcggcat gatcagaatg cccgagagtc cccgttggct tgtttctaaa ggaagaaaag 626641 aagatgcttt gcgtgtattg aaaaaaatca gggacgaaaa acgggcagca gctgagctgc 626701 aagaaattga attcgctttc aaaaaagaag accagcttga aaaagcgaca tttaaagatc 626761 tttcagtccc atgggtgcgc cgtattgtgt ttattggatt agggattgcg attgtacagc 626821 aaattacagg tgtgaattcg attatgtatt atgggactga aattctaaga aattccggtt 626881 tccaaacgga agccgcttta atcggaaata ttgcgaatgg cgtgatttcg gtattggcaa 626941 cattcgtcgg aatctggctg ctgggaagag tggggcgccg gccgatgctg atgacaggct 627001 tgatcggtac gacaacagca ttattgctaa tcgggatatt ctcacttgta cttgaaggat 627061 caccggcact tccgtatgta gtcctgtcat taacggtcac atttcttgct tttcagcagg 627121 gcgccatttc accagtgact tggctgatgc tatctgaaat tttcccgctt cgccttcgcg 627181 gactgggaat gggtgttacg gtattctgtc tgtggatggt gaattttgca gtcagtttca 627241 cgtttccgat attgctggca gctatcgggc tgtccacaac gttctttatc ttcgttggat 627301 taggaatttg ctctgtcttg tttgtgaaga ggtttttgcc ggaaacgaaa gggctttcgc 627361 ttgagcagct ggaggaaaac ttccgcgctt atgatcacag cggggcaaag aaggattctg 627421 gggctgaagt gattggataa tttaaaaaag aatccgcacc cgagtgcgga ttctttttgg 627481 tttcaaatta gttaggtcta acaaggattt tgacttggct tttctcttta ataagagccc 627541 cgaagccttc ctcgatcaaa tcatctagta cgattttttt cgttacgagt ttgtcggctg 627601 agaaatagcc ttctttcatt aatgacaata cagccgggaa gatgtcgcgg tatccgataa 627661 ttccttttac tgtacgttct ttgattacga tatcgttcgg atggatttca gcaccttttt 627721 cccaaatgct gacgatgacg gtttcaccgg caattgtagt ggactggatg gcttgtcgta 627781 acaccactgg gacaccagtg acttcgaatg ctacgtcaac accgcctcct gtacgttctg 627841 caatctcagc gactacatcg tctgttttag acggatcaac gatgatcgcg ccaagctcct 627901 cagctttttg ctggcgttca ggagaaagct caacagcgta aatatcagtt gcaccggcag 627961 ccttcagcgc ttcaatgaca agaagtccga tcgggccgca gccgaataca gccgctttgt 628021 cgcctgcttt gagtttgctt gagcggacag cgtatagagc aactgcagaa ggttcaacga 628081 gcgcgccttg ttcatatgat aattcatcag gaagtttgaa caaaagctct tcatccacag 628141 agacgtattc agagaaaccg ccgcctccgc cggctaagcc gaggaatccc atttgttcat 628201 caaggttgta ggcgccttgg tggccgtgtg tagcaaaaat cggctcgact acaacgcggt 628261 ctccaacttt ataattttca acgccttctc cgacttcgac aacttcaccg gagaattcat 628321 gccccattgt gacaggtgcc gtttcatttg ttaatgggtg cggtttgtca accggaataa 628381 agatcgggcc gcccagatat tcgtgtaaat cacttccgca gatgccgcac catttgactt 628441 tgatctttac ttttcccggc tccgtttttg gctcttcgat atgttcaata cggatatcct 628501 tttggttatg ccatcttgct gccttcatgg attaccactc ctataacttt tgatgtgagt 628561 aattccgcac cggtcaatat gaactgttca caaaatcgcc atttttaaaa ccaaaaaaga 628621 aatgaaattt ttatataata taatctacgt ttttttgaaa aaaagaaact ttaaagaaaa 628681 aagggtctcg cacactcttt tttctttata tgagagtatc aatcgtttac atagctatga 628741 atttggtttg aacaatacgg taatggttcg ttcatattga atgcgacaac tactctatca 628801 ataattataa ctctaatact gctattataa taggataatc ttccatggtt tattttagca 628861 gaggtaactt ttttgacttt gtaacattac tgtaaggata ttgaaataaa aaatagctgg 628921 ttgatcgtgt ataatcttcc tagatgttaa caaacagggg gacgaaatgt tgaagaaagt 628981 cattttagcc gcttttatct tagtaggaag tactttggga gcttttagtt tttcatcaga 629041 tgccagtgcg aaacatgtga acggaaatat tacttggtat aatggagtcg ggaaaaaagg 629101 ctcttcaggt aagaaacttg gacattggga ttgtgcgacc aaaatcggat ttgatgttcc 629161 tagaaacggg acaaaaatca gagcttatgc aaaagcgaag cctaaaaagg tgattacggt 629221 ttataaaaat gatgttggca gaatgcctaa tgcagtgctg gatgttagcc ctaaagcgtt 629281 taaagcgctt ggatacccat taagcaaagg taaagtagcg gggcattaca gctattaatg 629341 tacatatata atctggaaag caagaagtca cattcttgct ttttctattg gtggagataa 629401 aagatgaaaa aaagaatcat attattatta gcagtgataa tagcggcagc tgccgcgggg 629461 gttgcgtttt atgttgcaaa ggataaaggc catgagaagg ctgctgatgt ttcagtcaat 629521 accgaaagcg gtgatgagct gctggtttca attacagata cggatctgct gacaaagtat 629581 tatgaaaatg acaaggtgat ccatgaggag aagctgacca gctatccggc atttgccttg 629641 gatcaaaaac agcaggtgct ctattatacg ggcaataatg aacagaatga aatgaggctt 629701 tttaaattgg atctgaagtc tcataaaaaa acgatgcttt ataaaggcgc ggagagtgcg 629761 gacagtttat ttttatcaaa ggaccgttca accatctatt tccgcttagg aaaagcggac 629821 gaaagcaatt ttcgaatcgc cgcttttgat ctgaagacga aaaagtataa aaatctttat 629881 cctgccgcta atgatcagga tgacaccgtc agcagcttct tttataacca aaaaaacgat 629941 tcatttgcat tgcttcatta ttctgtagaa gaagactaca agaaaacaga tgaagcaaac 630001 gaaaagggca tcgaccctga accgacaacg attcattttg cggaaggccg ccaaaataaa 630061 tttaatgagc tgaaaagcct gaaccaattt atcagcgata ttgctgtttc tgatgatgat 630121 aaacgtattt tattcacatc atatacgcaa aaaggaacgg agcaaaccgc ttctattcaa 630181 atgctcaatg cggatacgaa aaaatatgaa agcatcatct caaatcaaaa atcatttaag 630241 ctgttaattg acgcacagcc tcagttttct aaggatggga agaacattta ttttcttgcc 630301 gaagccaagg gggctaaaaa gctgaaggac gaaacagggc gtgaagctaa ggtgcggacg 630361 atttattcct atagccttga gaataagacc ttcaaaaaag tatgggaaaa tccgaacggc 630421 atcatcaaca gcttttttgt gattaactaa taaaaaccac tcggcatgag ctgagtggct 630481 tttttaatgg atgaggtgca gggctaatga tccgagccat ttaaagatat gaatcagagg 630541 taccgacaaa aacagaagtt caacatatga gttcattgca acattcagct ttttgaacgc 630601 agctcttttt ttcaagtctt tttgctgctg gtttgagatc acgttatcac tcctcttata 630661 tccatattat accattaaaa cagacaaaaa agccctaaac gtttacagtt ttgggcttct 630721 ttcttcgtat ttggcctctt gcaatgagag gcttttattc tgaaatatag aattttgtct 630781 ccgttcgggg tttgtttgct tgcgggagac tgcatttgtt atagggaaga actagcttgt 630841 tttcgtttgg ctgttgtttt ggagattcac taatgaacgg atgccgtcga ccattttact 630901 tccgcacaaa gggcacaatg gcgtatcact gctggcgaag ttttttcggg tccagccatt 630961 acagtcttct tttgtgcatt cccaagtact cacatcttcc tttggcagcg gttcttgatt 631021 tcgtttgtta tagtaagaca taaagtcact tcttccctca tgtattttac tgcacatttc 631081 ctattgtctc atacttttcc ctaatctcct aattcctttt tctttatgac tttccaataa 631141 ccccatctaa aaaggagagg agtgtgctgt taaaagcatc tggctcttct aaaaacgggc 631201 aatggctgct tttaggaaag gtaacgagtg tcgcgtttgg aatattgctg cgcaagtgtt 631261 ccccagctgc tgtagagaaa aatttcttgt cttccccgaa gcacagcaat gccggcacat 631321 tgatgttttg gagggtgccc cggtaatcag cggccgtttg gttaaataaa atcgtgctag 631381 aaatggcagc cggctgtttg aggatttctg ccagcatcca ttctgtttcg gtctcggcag 631441 gcggttctgc gaacatattc tggatgaagc tttcgtagaa aggcagcggg tcagtttgaa 631501 tggcgtgcat cgctgttttt aagccgtcaa aatcaaatgg accatgttcc cagccctccc 631561 attgatagtc cgaagcggat tgatcgatga tcacagcggc ttgaatgtta tcattcccaa 631621 actgattgag ataatcccat acgacaaaag cacccattga ccagccggca agaacgacat 631681 gatcaagctc cattgcattt agaaattccc ttatgtcacg ggcatattgg gaaatggtgt 631741 ggccgtgaag cactttgtca gattcgccgt gtcctctaag atcaagacga atacattgat 631801 aattggcaga aagcaccgaa aattgtttgt ggaaaaattg tccgctcatc agcaccccat 631861 gtataaacag gatcggcgtc ccgctcccgt gtgtttcata gtaaaggcgt gtctgatctt 631921 ctaatatgat gtatggcatg tttctcctcc tttagtttcc atcatgagta tggctggctg 631981 ctgttgagct gatgatggca gctgtcgcgg ctgcctgctg cgcttgaatg actgtttcga 632041 tagcggtgta tagtcctgat tccatcagca gatttttctc catatgctca ctgagataga 632101 ggctgacagc aattttaaag ttcatttcct tttgccattt aaaagctttt tcctggttta 632161 attcgtcagt gatgcacaaa acggttttga tatctggctc ttccagaaat gtgaggagag 632221 caaggtctgg ataatgataa tcctttgttt ttttgacaga ttcagtgatc gattgatata 632281 tctgtttgca agcggaaaca agcatttcgg gctctttttc actttgcaag gccagaatat 632341 ggctgacctg atgtaagtac tgtccttttt taaagccgtt ggctgccagc agttgatagc 632401 atgtttccgc cttctgtagc gcctgcaaac cttttccgtt ttctccaagc agtacggcaa 632461 gcggaacatt ctgagttgaa gtgaggaaat aatgattttt cttcatctgc tgataaacag 632521 ctagccccat gttcatctgt tctttttggt ttgtcgtttc agatttgccg gtgagcaaga 632581 tcagagcgga aaggtatgtg aacatatccc gcttataccc tagcttcacc atttcattgt 632641 atacatcgat gaaagtctga aatgtttgtt ttgcctcatg ctgaaaatga atgtccagaa 632701 tagatgcaac agtaaagcgg tggtgtgaat tgagtgttga gaagctgccg atgtttgatt 632761 tgatatagct gctcaaatca taaaagcgct gaaaatcaaa ctctctttta ttcacaatat 632821 atgcagaaga aatgagcatt aatatctgat cgtgtgaaac tttccatttt aattttgttt 632881 ttaattcagc ataaatggaa atgtaatgct ttgttttttc atgtagatcg tgtgtgagca 632941 taaaaagcag ctccttttgt tgtttttacg taatacgata aatagggcca aaggtttcat 633001 aaagaaaaaa cttgcctgct agaggcaagt ttgtcgggtt atttatgggg atcagttata 633061 tccatcggtc tcatcatgtc atagtcttca tgctctagaa tatggcaatg ccatacgtat 633121 cgtccgctgt acggaccgaa tgtcgccgcg attctcagga cttcacctgc atgcgcttga 633181 atggtgtctt tccagccctt ttcacttggc ggcggcggga cagccggacc ggtataggac 633241 aattccccgc tttcttgata acgggcgata tcaaacggcc gccggtctaa tacacggaag 633301 gagactagat gcaggtggat cggatgtgtt ccgcgtgtcg ggttgataat ggaccatatt 633361 tcagttgtgc cgacttttgg tgtttctgtg acgggatcgt gccagcgttt gttattaagc 633421 agaaggacgg gtctgccgta ttcgtcctgg gtgcctgcca gttttaacgt tctgatgttt 633481 tgtattcttt catgctgtac cgaagggtat gaggcgaggt acttcggctt tctgctttcg 633541 tctttttgtg ccaatggttt tgtgactctg aattgcatga tattcgcatc tgtttcagga 633601 ttgacgtcac cgccgcagcc cgcgctgttt gccaaaatga tcgattctcc ttcatatgct 633661 gtgaagtcaa tgatgatatc gtaacgttca gcaggcgcaa ggctgaaaga attcagttta 633721 acagatcgcg gcaggagccc tccatctgaa ccaatctgaa taaaatctcc gccattatcg 633781 agtgacaggt tataggttct tgtattggag gcgttgatga cacggaatcg gtatttcctt 633841 ggctcgactt ccaagtatgg ccataccttc ccgttgacga gtatggtttc tccgcaaaaa 633901 gccggaacga ttgaaggatt aggcagtgac ggagaagggt tttccggtgc gctcggataa 633961 aacaaagaac catcctcatt gatcgtgcgg tctgtgataa gaagcggcac atcgtattcg 634021 tctgaaggca gttttaagcg tttttccttt gggtcatgaa tgatatatgc accgacaagt 634081 ccggcataga catttagcct ggtgagcgcc atggcgtgat cgtgatacca caatatagcc 634141 ccgcgctgct ggtttggata atgataaacc tctcttttga aataaggtcc tgtttgttca 634201 aagtctttgg aaaaccaagc ctccggatac ccgtcactat catctggcgt gacgccgccg 634261 tgtaaatgaa caacagtctt tacctcgggc tcttcatgct ggctgtcact gtgatgaatg 634321 gtgtgatcaa tcggaaggaa atgcgtggaa ggaaggttat tcatccattt tacatatacg 634381 ttttcatttc ttttaacctc aatggtcggt cccggaaata agccgttgta gccccacagg 634441 cgggttggag ggagatcgcg atggagctga tgagtgcatt cctccatggt gacttcgtag 634501 tatgtttttt cttttgattg ctgtactggc tttagtgtat ctgggattgg gagagcatcc 634561 acaaattttt caagtgtcat tttcatctgt ccttatctaa attttccaaa ttggtactat 634621 agttaatgac aataaggacg tgatggttac aaaaaatctt cgtgctgcag cccgcccgaa 634681 gaagaaaata acaaaatcct aaacggcagg ccgtttagga tttgatcagc attaaggcag 634741 gatatcgggt tgctgctgtg tgactgggtt ggcagccgct ttctcgctca ccttgcgttt 634801 tctgaacaca aggtaagaaa tcagaacgat tcccgtgatg acgcctgtca gcagcagctc 634861 gtctctcatg gaatcaataa acgccatgga cactaaaatt ccgcaaatgg cgatgatggt 634921 caagtaggtt aggaaaggga agagccacat tttgatcttc aatgcttctg ggtttgtttt 634981 ttcgagtttt ttccgcattt tcagctggga aacggcgatg acaagataga cgagtaaagc 635041 gattgcgcct gatgagttga ctaagaataa aaagacggta tccggtgaaa aatagttcat 635101 tacgaccgcg atataagaga aaaatgtccc ggccacaatg gcttgtacgg gaacgccttt 635161 tttgctcaat ttcataaaac ggcgcggcgc ttcatttctt tctgcaagtg aatacagcat 635221 tctggatgtg gtatacaaac ctgaattcag gcaagagagt acggctgtga ggacgataaa 635281 gttcataatc tgtgcggctg cgggcactcc tatatgctca agtacagcga cgaaagggct 635341 ttctaaaata tttgctgaat tccatggcaa cagcgccacg acaatggcga ttgagcccac 635401 gtaaaagacg atgatgcgcc atacaacgga tctggtggct tttgtcacag attcgatcgg 635461 gttggatgtt tcccctgctg caatggcaac gatttcagtt cccataaaag agaagatgac 635521 aacgacaatg ccgagcaata cggagctgat gccctccggg aaaaatccgc ctttgcctgt 635581 aagattcgaa aaaccgactg gctcactgcc cggtgcaaag ccaaaaataa aggcaaaacc 635641 aacgattaga aaagcaatga tagtcacaac tttaatgagg gagaaccaat attcaaactc 635701 accgaaagac ttaacggagt agacgtttgt cagggtgagc acaatggtca agatcaaact 635761 tgtcagccac agcggaatat catggaacca gtattgaata atgccagcac cggcaatggc 635821 ttcgatcgct atgacgatca cccagaaaaa ccagtacagc cagccgattg taaatcctgc 635881 ccacggtccg atggcgtcgt gagcgtattg agaaaacgat ccgctcgtcg ggtttacggc 635941 agacatctca ccgagcattc tcataataaa aatcaccaat aatccggcta acgcgtaaga 636001 aacaacggca cccggaccgg tcgagtgaat cactgaaccg ctgcctacaa ataggccggc 636061 tccgattaca ccggcaatcg aaatcattgt catatggcgg gtctttaatt ccttttttaa 636121 tcctgattga gactggttca taagttacct ccttttaaaa tgcaatcatt actgaatatt 636181 atgataattg aaactctatc ataaatatac agtttgtcga aaattcgtgt aagaaaatat 636241 accagcttat ttcaaatttg tagtgttttg tttgcgcttt cagcgaatgt gtggaaaaaa 636301 tgtttcgttt tttattcgct gtgtgatttt gcgtaatatt tacaattcga tagaatgcga 636361 gaagcactgg tgtccttggg tttgatggga tttttggcgg agcaaataaa ttggatgaga 636421 gaaaaagtgt tccttcgtca ctatttttct gtggcgggtg aatcatgttt ctgtagaccc 636481 actgcggatc agctttgtaa gataataata ggaaaatgtg agcgagagga ggttttgtat 636541 ggagagatat gatgaactga aaaagggaga atccggagcg ctggtcagca ttgccgcgta 636601 tctagttctt tccgcaatta aactgatcat cggttatctt tttcactcgg aagcacttac 636661 ggcagacggg ttaaataaca caactgacat tattgcttct gttgctgtgc tgattggcct 636721 gcgcatctct caaaagcctc ctgacgaaga tcatccatac ggccactttc gagcggaaac 636781 gattgcatcg cttatcgcat cgtttattat gatggttgtc ggactgcaag tgctgttcag 636841 cgccggagaa tctatttttt ctgctaaaca agagacgcca gatatgattg cggcttggac 636901 ggcagcgggc ggggcagtcc tgatgctgat cgtttaccgg tacaataaaa ggctggccaa 636961 aaaggtgaag agccaggcgc tccttgctgc ggctgctgat aataaatcag acgcattcgt 637021 cagtatcggc acatttatcg gcattgtggc tgctcaattc catcttgctt ggattgatac 637081 ggtcactgcg tttgtgatcg gtctgcttat ttgcaagacc gcatgggata tctttaaaga 637141 gtcatctcac tctttgacag atggattcga cataaaggac atttccgctt ataaacagac 637201 aatcgaaaaa atctccggtg tgagccgttt aaaagacata aaagcaagat acttgggcag 637261 tacggttcat gttgatgtgg tggttgaggt atcggcagat ttaaatatta cggaaagcca 637321 cgatatagcc aatgaaattg agcggagaat gaaggaggag catgcgattg attattcgca 637381 tgttcatatg gagcctttag aacaaaaata atggagcttc ctgtcacagg aagcttcagc 637441 gtgtcgacaa accctcgcat tcgttgtcag gtctgcgctt cggtgctcac gaattagaac 637501 attcgctccg ctcctatgct cgtccttcct agacttcaag ggttttcaat cacgctgaaa 637561 agatgacaaa accctaaaat gaaagccatt ttaggatttt gtcaacaatc tggagcttcc 637621 tgccacagga agcttttttg tgtgttttgg ccagctttat tggtaacaat ttgctagaat 637681 cgttttttta tacagattgc tttttgtggt aaagttaggt tacattatga tgaattttgt 637741 agatgactag gaggaaaata atggcatatc aagaagacct gcatcctttg ctggggaaag 637801 cagttgaaca tattaataga gtaatggttg gaaaacgaga catcgccata ctcagcttag 637861 cagcccttct tgccaaaggg catgtgctgc ttgaggatgt acccggagtc ggaaaaacga 637921 tgatggtccg cgcgctggca aagtcaatcg gcgccgattt caaaagaatc caattcactc 637981 cggatttgct gccatctgat gtaacagggg tatctatcta taatgcgaaa acgatggaat 638041 ttgaatatcg tcccggccca attatgggaa atatcgtgct ggcagatgaa atcaaccgta 638101 cctctccgaa gacacagtcg gctttgctcg aagcgatgga agaggggagc gtcacggtag 638161 atggccatac gatgcagctt gccgatccgt tttttgtgat ggcaacgcaa aacccggtcg 638221 aatatgaagg gacctatcct ttgccggaag ctcagcttga ccgtttttta ttcaaacttc 638281 ggatgggtta tccgtccttt aatgaagagc ttgacgtctt atctcttcag gaaaaaagcc 638341 atccgattga gacgcttgag ccggttattg caaaagaaga cttcatcttt ttacagaggg 638401 aagtgcaaaa tgtccgtgct gatgacagca ttaaggaata tatcgttgaa attgtgcaga 638461 aaacgagaca gcatccttct gttcaattag gcgtcagtcc gcgcggctca atcgccctca 638521 tgaaagcggc acaggcatac gcgctgctgc atcatcgcga ctatgtcata ccggatgata 638581 ttcaatattt agctcctttc acgctgccgc accggatgat gcttcatcct gaggcaaaat 638641 ttgaagggat tcaggcagaa gcgatcgtaa gggagatcat gtcagctgtg aaggtgccgg 638701 ttcaaaggtc ggcggtccgc tgatgaataa gaaatggcaa tggctcgtat atggttggaa 638761 gctgattata ttaactttat tgacggctgc tgttttttct tatgcgatgt ttcagggcgg 638821 ctttgtcagc tggtttttgt tttacgcgtt tctccctttt gtcttgtatg ccgggctgtt 638881 ggccttgtat ccgctccgtt cttttcaggc ttcaaggcaa atggataaaa cacaattgca 638941 tgcgggggac aggctgggcg taacggttac gctgagaaga aagctgccat ttccgctgat 639001 gtatatggtg attgaagatt gcctgccaga aggtatcgag tcattaaatc gagacggagc 639061 cgcggccaaa cggctcgttt ttccttggtt taaacggagc atgacgatgt cgtatgaatt 639121 agctcgggta ccgcgcggag agcatcactt tcattctgtc agggtgcgaa ccggggatgt 639181 tcttggcttg attgaaaaaa cagcattttt tgagctggat gataccttgt ttgtttatcc 639241 attctatcag cgtttttcct atcaggtgaa tgagaggcat caggaagacg gtgtaagcgg 639301 ttcttctcct attcatcagc accattcctc agtcgcagca agtgtgcgga attatcagcc 639361 gggagaccgg tttgctgcgt tagattggaa gacatctgca cggcggagcc agctgatgac 639421 gaaggaattt gagccttctc gcagcaaaaa tctgtttctg ctgatggacc gtttttcctc 639481 agacgcattc gaagaggtcg tttcagtgac agcttcgatt cttcattctg ttttaaaaaa 639541 cggcgcgggt gctggtctgg cttccatcgg gaaggaaaaa aacattttcc ctattcagga 639601 aggggatcag cattttaagc acatgcttcg gcatttagcc atcgctcatt gtgatgcggc 639661 agacccgata agccgatatg cacgggaaga gctgggaaag ccatctgttc gccaagctga 639721 tcaagttgtt gtcacgggac agttaacgga agatatgctg cacctcgcag aaataggagg 639781 cggccgggtt acggtgatac tggcaaaaga gaaagatgct gagctctctc aagctgaaaa 639841 tgtcatgatt gaacgcatga tgaaacgcca aatcagagtt cggatcatga ggggcgggcg 639901 agtttcgcgt gttgtttaga aagagaggtg actggttcac atgccgcacg atgatcacaa 639961 gggaagccgt ttgagcttgc tgttatttta ttttctggct tttttattgc tgtgggagtg 640021 gcttaggccg cttgacagtt ttactgaaac gaaacataca ggctttttta gtgtctttat 640081 cggcttgacg tttctgctga cttttttcag gatgaggtgg tttgtcaccg ttcctttttg 640141 tgtcatattt acattgatct cgatacacat cctgttttat caaggatcta tattcgactt 640201 gagctgggtc agctcttttt tgcaggatgt ctatctgaat atcacgctga ttcaatcagg 640261 gcaatggaat gacatgattc cttcatttcg gaccctgctg ttttttgtgc tgctgtggct 640321 gctggtctat ctcctgcatt attgggtgat ttaccagaga agaattttgt ttttcttttt 640381 gatgacagta gcgtatatta cgattcttga tacctttacg ccatatgatg ccacttttgc 640441 cgtaatccgt atcgtgctga tcggcttctt tatgctgggc cttttatact tggaacgcat 640501 taagctgatg gaaagaatca cactgccaaa aacatctgtc ctgaaatggt ttcttccttt 640561 atctgtattg gttttggctg caacgggatt cggactcgcc gctccaaaat cagagccggc 640621 ttggcctgat ccggtgcctt ttcttaaaaa aatcactcat caagaccgcg tgtctgcagg 640681 ggaaagcaaa atcggatacg ggaatcatga tgaatcactc ggcggcccgt tccagcagga 640741 tgctacacct gtttttacat ggcagggaaa agagcgtacg tatttccgtg tggaaacgaa 640801 ggacacgtat accggaaaag gctggattga aacagacaca ggcatgtcgt atcagcttag 640861 caatggaaaa gttgaaaatc tgtggtttga ccataaggtt gcgacagagc gccgcaccgt 640921 ccgtgtaaaa gtcgataagc actacgggta taaccatctg atgtatccga ttggtgcgga 640981 aaccattcag ccaaagcagg ctgtctcact tgaaatgaac ggcaacacgg agcaaatttc 641041 tccgatcagt gaacaagccg gtgaaatcag aaatatgggg aattatacag taacgtacaa 641101 ttccccggtc tataagctgg atgaactgag aaaggtaaaa gtgagaaaaa acagtgagga 641161 gtacacattc agcgatcgct acatgcagct tccagattca ctgccagagc gggtgagaac 641221 ccttgcgatc aaactgactc aggatcacga caatatgttt gataaggtga aagcggttga 641281 ggactattta gggtcaaatg cgttcacata tgaaacagaa aacgtgacca ttccgaagaa 641341 tgatgaagat tatgtcgatc aatttctctt tgaaacgaaa atgggttatt gtgataactt 641401 ttcttccgcc atggtggtgc tcttgcgctc ggccggcatt ccggcccgct gggtaaaggg 641461 ttatacgtcc ggcgaataca aagaagcagg gaacaaaaat ggcagcattt acgaagtgac 641521 aaataacaat gcccattcct gggtagaggt gtatttcccg gaacagggct gggttacatt 641581 tgagccgact aaagggttta caaatccggc tcaatttaca tcttctgaca caaaagactc 641641 tggcagcgat agcagcagct cgccgaagaa agcaaaagag aaacagaaag aagagaaaaa 641701 acagccgcaa aaagaggaaa aacaaaagga aaagcgggag ccagctgttt ctaaaaagcc 641761 gtccgcttcg catactaatg ccggtgcggg cttgtatgca gcgcttgcgg ttcttgcagt 641821 cctcctggtg gcagctgtat tgctgtatgt tttccgctcg ttatggattc ctgttttcgc 641881 cgtgaggaaa ttgaagcggc gcagtgatca gcacgcgttt tttgaggcat atggcgcgct 641941 gctgaaacaa ctgaagagaa aaggactgcc gaaacgagac agtgaaacgc tgcgtgatta 642001 tgcaaaacga attgatgaaa aatacgacat agaagacatg tcaaagctga cattaagcta 642061 tgaaagggcg ctttacagaa atgaagattc ttcggcgcta tggaatgatt cgagagagtt 642121 atgggaaaat ttaattaaaa gaagatggtc ttgaccgctt atcgacgtgt tgttagaatt 642181 agtgaatatt atcggagtct gggagcgagt tggcctgact ccggcaaacg gccttgccaa 642241 agagggcgga gcgagcttca tatctgtcct cgtttttttc tgtgtcaaaa aacttagagg 642301 agattaggtg acaaccatga caaagttagt gaatgaaatg attcttgtcc ttgatttcgg 642361 cagtcagtat aaccagctga ttacacgccg tatccgtgaa ttcggtgttt acagcgagct 642421 gcatccacat acattgacgg ctgaagaaat taaaaaaatg aatccaaaag gaattatttt 642481 atccggcggt ccaaacagtg tgtatgatga aaactctttc cgctgtgacg agaaaatctt 642541 cgagcttgat attcctgttt tgggaatttg ctacggcatg cagctgatga ctcattacct 642601 tggcggtaaa gttgaagcgg caagccagcg tgaatacgga aaagcaaaca tccgcatcga 642661 aggcacacct gatttgttca gagatcttcc gaatgaacaa gtggtttgga tgagccacgg 642721 cgatttggtt gtagaagttc ctgaaggctt cactgttgac gcgacaagcc atcactgccc 642781 gaactcagca atgagcaaag cggacaaaaa atggtatggc gttcagttcc acccggaagt 642841 gcgccactct gaatacggca atgatcttct gaaaaacttt gtattcggtg tttgcgaatg 642901 cgaaggcgaa tggtcaatgg agaactttat cgaaatcgaa atgcaaaaaa tccgtgaaac 642961 ggtcggagac aaacaggttc tttgcgcgct aagcggcggc gttgattcct ctgttgttgc 643021 tgttttgatt cataaagcga tcggcgacca gctgacttgt atctttgtag accatggtct 643081 tctccgtaaa ggcgaagctg agggtgttat gaaaacattc agcgaaggct ttaacatgaa 643141 tgtgattaaa gtagacgcaa aagatcgatt cttaaacaaa ctaaaaggcg tttctgatcc 643201 tgagcaaaaa cgcaaaatca tcggtaatga attcatttac gtgtttgatg atgaagcgga 643261 caagctcaaa ggcatcgact accttgcaca aggtacgctt tacacagata tcatcgagag 643321 cggtacagca acggcgcaaa cgatcaaatc tcaccacaat gtcggcggac ttcctgaaga 643381 catgcagttt gagctgatcg agccgttaaa tacgctcttc aaagacgaag tgcgcgcgct 643441 tggcacagag ctcggcattc cggatgaaat cgtatggcgt cagccgttcc caggaccggg 643501 actcggaatc cgcgttcttg gcgaagtaac agaagaaaaa cttgaaatcg ttcgtgaatc 643561 agatgcaatc ttgcgtgaag aaattgcaaa tcacggctta gagcgtgata tctggcaata 643621 cttcactgtt cttcctgaca tccgcagcgt tggtgttatg ggtgacgcaa gaacatatga 643681 ttacacaatc ggaatccgcg ccgttacatc aatcgacggc atgacatctg actgggcgcg 643741 tatcccgtgg gatgtgcttg aagtcatttc gacacgtatc gtaaacgaag tgaagcacat 643801 taaccgcgtg gtgtatgata ttacaagtaa gccgcctgcg acgattgagt gggaataaga 643861 atcaattaat ggaaaccatc tttttggcaa ttttgccggg aagatggttt tatttgttta 643921 ttacgaacaa aatccgattt tgcgcgacta ttgttcgctt tttgtattgt tttttcaaaa 643981 tgaacttggt acaatagaca cagaaatcaa ataagatgaa ttcgtataat cgcgggaata 644041 tggctcgcaa gtctctacca agctaccgta aatggcttga ctacgtaaac atttctttcg 644101 tttgatataa ataaaacacg gttatttatt caaactgaaa tccgtctgta gtcaagcgtc 644161 ccaaaatgta ttgggacgtt ttttatttgg cgttttcagg acagaataaa tagcaaagag 644221 tgaagggagt caaatagctt gaaaacgttt tttcagtttg atgagctggg caccagctat 644281 cgcaatgaaa tcattggcgg attaacgact tttttatcta tggcatatat tttgttcgtc 644341 aatccgatta cgcttgcttt ggagagcgtg aaagattttc cggaggcgct gagaattgac 644401 cagggtgcgg tctttacggc gacagcgctg gcgtctgcag caggctgtat cttaatggga 644461 ttaatagcga gatatccgat tgccatcgcg ccgggtatgg ggctgaacgc gttttttgcg 644521 ttttctgttg tccttggtat gggtatttca tggcaggcag ctttgtccgg tgtttttatt 644581 tcaggtctta ttttcgttgc tctttcttta acaggttttc gtgaaaaaat catcaacgcc 644641 attccgcctg agctgaaatt ggcagtcggt gcggggatcg gcctgtttat tacatttgtt 644701 ggattacaag gttcaggaat cattacagcg aatccttcta cgctcgtcac gatcggaaac 644761 attcacagcg gtcctgtgct gttaacgatt ttcggtgtga ttgtcacggt tattttaatg 644821 gtgcttcgcg tgaacgcagg cgtgtttatc gggatgctat taacagcggt agccggcatg 644881 attttcggtt tggttccggt tccgactcaa attatcggca gtgtgccaag ccttgcgccg 644941 actttcggac aagcgtggat tcacctcccg gatattttct ctgtacaaat gctgatcgtt 645001 attttaacat tcttgtttgt cggatttttt gatacagctg gtacacttgt tgctgtggca 645061 acacaagctg gtttaatgaa ggaaaacaaa ttgccgcgtg cgggccgtgc gcttttagct 645121 gattcatctt ctattgtgat cggtgccgtg cttggtacgt ctacaacaac ttcttacgtg 645181 gaatcaagct caggtgtcgc tgcgggtgcc cggtcaggat ttgccgcaat tgtaacaggg 645241 attctctttt tactggctac gtttttctcg ccgctcctat cagtcgttac gtcaaatgta 645301 acagcgccgg cgcttattat tgttggtgca ttgatggtgg cgccgcttgg caaaatcgct 645361 tgggataagt tcgaagtggc cgttcctgct ttccttacca tgatcatgat gccgttaacg 645421 tacagcatcg cgactggtat tgccatcgga tttattttct atccgattac aatggtgtgc 645481 aaaggaaaag caaaagaggt tcatccaatc atgtacgggc tgtttgtcgt atttatcctg 645541 tactttatct tcttaaaata aggaatgaaa aaccagctgc actggcagct ggtttttttg 645601 ttgcaaaaga taaaaccatt tcatacgata taccgtcatg tagatgtgcc gccatgcttt 645661 acttaaatgg aaatgacttg actgttcagg aaggcttcgg taccttatat aagtgtttta 645721 ttttcttgct gaatggtatt ccgccgtatt tttttgatag gagttgctga catgacggaa 645781 gaaagaaaag aaacgtttga agaagaaatt aaccagagtg aaagaataga tgcagatgaa 645841 gaaccgctat cgagaatgtc cagaaaggcg agccggcaaa gcaagcagaa gcaaaaacaa 645901 aagcagaaac cgcgccagga acgcggtgaa tcaactgtta aagacaagct tgcgtctgtt 645961 tgggcagcca tcaacagata ttgcggtttt gcgttctcga ttttaaaatc tccggcgaaa 646021 actgtcgtaa cggatggttt ttctcattat aagtacggtc tgatttcaat gcttatattc 646081 agtatcattt tttcaattgg gaattggttt cagttaaagg caagctggaa tcggccgctc 646141 ggtttcggag aacgccatca tgctttctat gacgggtttt tagttgttct tgtgtatttg 646201 ctgatctttt tcgcggtaat ggtctttgct atatgggctg tctcccgcta tatgatgaag 646261 cagaaggtga cgttcagaga agcggctgcc gtattgggtt cattgcttgt acccgtaatt 646321 gctgtttcaa tcctttggct gatctttgcg atcgtaaata tcccaatgct gacagtactg 646381 tttacggtgc tgatcttgtt ttccatcttt tttatcatcg cgctgtatgt acagcgtgtg 646441 taccaggcgg cacaagatgc accaattgat tatatctatt gtgtatttgc agtagttgcg 646501 atagcgctgc tgtttacggc agtgacttgg ccgtttattt ctgaatatat tacggcgtcg 646561 ttgattccgc tttaatgaaa aaaccggcta atcctagccg gtttttttat gtcacacttt 646621 ttacaaatat atctaaaaaa catagttgat ttgtaggatt aacccgtgta tgatggggaa 646681 aatgctgaaa acgtccagcg caaaaacctt tatgtttaag gaggatgatg gacatggctg 646741 atgtacttcg ccgagcaatt aaccaaaaga agcaattttt aaaaaccaaa ttactgctct 646801 cggaatttta tcaaggaaga ggggaacagc ttgctgacta cacgctgagt gagcttgaga 646861 aagaatacaa gtcccttcag aaaatgaaaa aagagatctg acaatagata taaagaggtg 646921 agtctgctga aaagcgggct tttttgtttt gattttgaaa aggcgagaaa gagggtaaac 646981 tactactgtt caacacataa aagcgtgtcg aaatattttg cttaagctta cgggcgaagc 647041 tgattgtaaa cggctcattt ctctagtaga atatgaatgc tttgtgcaag ctgaagagta 647101 gggggatgaa taaaatgatg caaaccatct tatcaaatgg gatagccatg gttctcataa 647161 ttctcattat taatattgtc tatgtgtcat tttttacgat aagaatgatt ttaacgctga 647221 aaggacagcg ttatttagcg gccggcatca gtacgattga aatactggtt tatgtgacag 647281 gactgagtct ggtgctcgat aacttagacc agattcaaaa tgtgatcgcg tacgcgctcg 647341 gttacggtct tggcgtaatt gtcggcatga aaatagaaga aaaattggcg cttggctata 647401 ttatggtcaa tgtgattacg aaggagctcg atcttgatct tccgaagcag ctccgtgaaa 647461 aaggctacgg cgtgacaaac tgggtggcag gcgggcttga aggcgaccgc acagcccttc 647521 agatcctgac gccgagaaga tatgaactcc agctatatga tacgattaaa acacttgatt 647581 caaaagcctt tattattgcg tacgaaccaa aaacaatcca cggcggcttc tgggtcaaag 647641 cggtgaagaa gaggagaatt aaagaataat ggcaaagccg aagaagaaaa agtttgaagt 647701 gacagagcag caaacgattg atgcggtgct tcagcaaatg aaagaagaag gatatctgcc 647761 tgtaaggcga atggaagagc ctatttttat ggaaaaaaag gaaaatgggt caattcagat 647821 cgttccgtgc gggaaaaaaa tcgtatttga agggaaattg atctaaaaca cgaacattag 647881 tagaatgaat ttttgtatcg ttcgataata tcgttgacat tatccatgtc cgttgttaag 647941 ataaacatga aatcaaaaca cgacctcata taatcttggg aatatggccc ataagtttct 648001 acccggcaac cgtaaattgc cggactatgc aggaaagtga tcgataaaac tgacatggat 648061 atatcgcaga agcgaacgac tgacgataca tgtaccatgc ccggtttgta ttgcttcctc 648121 ataagtgcaa tgcagagcgg gtatttttta ttttctgaaa acaaaagcat tagaaggtgg 648181 ggaacagaat gcagccgcta gtaggaatca tcatgggaag cacttccgat tgggagacaa 648241 tgaaacacgc atgcgacata cttgacgaac tcaatgttcc gtacgaaaaa aaggtcgttt 648301 ccgctcaccg gacgcctgat ttcatgtttg aatatgctga aactgctaga gaaagaggca 648361 tcaaggtgat tattgccggt gccggaggag cggcgcatct gccagggatg acggctgcga 648421 aaacaacact gccagtcatt ggagttccgg ttcagtccaa ggcgctgaac ggaatggatt 648481 cacttctttc catcgtccaa atgcctggag gcgtgcctgt tgcgacaaca tccatcggca 648541 aagcgggtgc tgtgaacgca ggcctgttag cggcgcaaat tttgtcagca tttgacgaag 648601 accttgcccg taagctggat gagagaagag aaaatacaaa acagacagtg ttagaaagca 648661 gtgatcagct tgtctaaaca aatcatctat ccgggagctg taatcggcat tatcggcggc 648721 ggccagcttg ggaaaatgat ggctgtgtcc gccaaacaaa tggggtataa agtcgcggtc 648781 gttgatccgg tgaaagattc gccgtgcggg caggttgcgg atgtcgaaat taccgctcat 648841 tataatgacc gtgaagcgat tcgaaaattg gctgaaatca gcgatatcat cacatatgag 648901 tttgaaaaca tcgactatga tgcgctgcat tggctaaaag atcatgcgta tctcccgcaa 648961 ggaagtgagc tgctgcttat tacccaaaac cgtgaaacag agaaaaaagc aattcaatcc 649021 gcgggctgtg aagtcgcacc gtacagcatc gtcaaaacaa agaatgaatt gaaacaggca 649081 gtacaggagc tcaggcttcc ggcagtgctg aaaacatgcc gcggcgggta cgacggcaaa 649141 ggccaatttg tgataaaaga agaggcgcaa atggagcagg cagccgctct gttagaacac 649201 ggaacttgca ttcttgaaag ctgggtttct tttaaaatgg aactgtcggt gatcgtcgtt 649261 agatcggtaa acggtgaaat ttcaacattt ccgacagctg aaaacattca ccacaacaat 649321 attcttttcc aaagcatcgt gcccgcacgg gtagagaaag ggattcagca gaaggctgct 649381 gatctcgcag ttaagcttgc agatgagctt aaccttgtcg gaccgcttgc tgttgagatg 649441 ttcctgacag aggacggaga gcttttggtc aatgaactgg cgccaagacc gcacaattca 649501 gggcattata cgctggacct ttgcgagacg agccagtttg agcagcatat cagagcggta 649561 tgcgggcttc cgcttgggaa gacagatttg ctgaagccgg gcatgatggt gaatcttctc 649621 ggcgatgaag tgaagcttgt tgaggaagac ccggagcttt taaaagaggc aaagctatat 649681 atatacggaa aacatgaaat caaaaaaggc cgcaaaatgg ggcatattac atttatgaag 649741 cagcctgaag acgaatggat tcaggagatc acaaataaat ggatgaatag agacggagga 649801 caagcagaat gatcgaacgt tattcaagac ctgaaatgtc cgcgatttgg acggatgaaa 649861 acagatttca agcatggtta gaggttgaaa ttcttgcctg tgaagcgtgg gcggagcttg 649921 gcgtcattcc gaaagaagat gtaaaggtta tgcgcgaaaa cgcgtcattt gacatcaacc 649981 gcattttaga aatcgaaaag gacacgcgcc atgacgttgt cgcttttacg cgcgctgtat 650041 ccgaatcact gggcgaagaa agaaaatggg tgcattacgg cttaacgtca actgacgttg 650101 ttgatacggc tctttcctac ttattaaaac aggcaaacga tattttgctc aaggatcttg 650161 agagatttgt tgacattata aaagaaaaag cgaaagaaca taaatacaca gtcatgatgg 650221 ggcgcacaca cggcgtacac gctgagccta caacattcgg cttaaaactt gcgctttggc 650281 atgaagaaat gaaacgtaat cttgagcgct tcaaacaagc gaaagcaggc atcgaggttg 650341 gaaagatttc cggtgctgtc ggcacatatg cgaacattga tccatttgtt gaacaatatg 650401 tctgtgagaa gctcggattg aaagcagcac cgatttccac tcaaaccctt cagcgtgacc 650461 gccatgctga ctatatggca acacttgctt tgatcgcgac aagcatcgag aaattcgctg 650521 tggaaatccg cggactgcaa aagagtgaaa cacgtgaagt agaggaattt ttcgcgaaag 650581 ggcaaaaggg ttcatctgca atgccgcata aacgaaatcc gattggctct gaaaacatga 650641 caggcatggc gcgcgtgatc cgcggctaca tgatgacagc ttacgaaaat gttccattat 650701 ggcatgagcg cgatatttct cattcttcag cagaacgaat tattcttccg gatgcgacaa 650761 ttgcgctgaa ctacatgctg aaccgcttct ccaacatcgt gaagaactta acggtcttcc 650821 cggaaaacat gaagcgcaac atggaccgca ctctcggcct tatctattct cagcgtgtgc 650881 tccttgcttt gattgacaca ggcctgactc gtgaagaagc ctatgataca gttcagccga 650941 aagcaatgga agcgtgggaa aaacaagtgc cgttccgcga gcttgtggaa gcggaagaga 651001 aaatcacgtc acgtctttct ccagaaaaaa ttgctgactg ctttgattac aattaccatc 651061 tgaaaaatgt tgatctgatc tttgaacgtt taggtttagc atagaagaag cttttagcgg 651121 cttcttctaa gccgccgcag tttgaaaatt cccaacattc gggttaggag gccttccgtg 651181 aatattgtga agaatgaact tttatacgaa ggaaaagcaa aaaagatcta caaaaccgat 651241 gacgaaaaca cgctgtatgt cgtgtataaa gactccgcca ctgcctttaa cggcgagaaa 651301 aaagcagaaa tcagcggaaa agggcgctta aataatgaaa tttcaagcct cattttcaaa 651361 caccttcatg ctaagggcat taacaatcat tttatcgagc gcatttcgga aacggagcag 651421 ctcattaaaa aggtaacgat tgtgccgctt gaagtcgtgg taagaaatgt tgtggcagga 651481 agcatgtcca aacgtctcgg cattccagaa ggcacggagc ttgagcagcc gattatcgag 651541 ttttactaca aggatgacgc gctgggtgat ccgctcatca cagaagatca tatttggctt 651601 ttgaaggcgg cgactcctga gcaggtagaa accattaagt ccattacaac aatagtaaat 651661 gaagagcttc aaagcatctt cgacgattgt catgtcagat taatagattt caagcttgaa 651721 ttcggtttag atgcagaagg gcaagtgctt ttggcggatg aaatatctcc tgacacatgc 651781 cgcttgtggg ataaagaaac gaacgaaaag ctggacaaag atttattcag acgcaatctg 651841 ggaagcttaa ccgacgcata cgaagagatt ttcaatagac tgggaggcat tcatcatgta 651901 taaagtaaaa gtttatgtca gcttaaaaga aagtgtacta gatccacaag ggagcgctgt 651961 ccagcatgcc ttgcacagta tgacttacaa cgaagttcaa gatgtgcgca tcgggaaata 652021 catggagctt accattgaaa aatctgaccg tgatcttgac gtgctagtga aagaaatgtg 652081 cgaaaaactt cttgcgaaca cagtgattga agattataga tatgaggttg aggaggtagt 652141 cgcacagtga aatttgcggt gattgtgtta cccggctcca actgtgatat cgatatgtat 652201 catgctgtaa aggatgagct cggccatgaa gtggaatacg tctggcatga ggaaacaagc 652261 cttgacggct tcgacggcgt gttaattccg ggaggatttt cttacggcga ttacttaaga 652321 tgcggcgcca tcgcccgatt tgcgaatatt atgccagctg tcaaacaagc agcggctgaa 652381 ggaaaacctg ttcttggcgt ctgtaacgga ttccagattt tacaggagct tgggctgctg 652441 ccaggcgcaa tgagacgcaa caaagatctg aagttcattt gccgtccggt tgaattgatt 652501 gttcagaacg acgaaacctt attcacagct tcctacgaaa agggagaatc gattacaatc 652561 ccggttgccc atggtgaagg gaatttctac tgtgatgacg agacgcttgc tacattaaag 652621 gaaaacaatc aaattgcttt cacatacggc tctaatatta atggaagtgt cagcgacatt 652681 gccggtgtcg tgaatgagaa aggcaatgta ttaggcatga tgcctcaccc tgagcgcgcg 652741 gtcgatgaac tgcttggaag cgccgacggt cttaaattgt tccagtctat cgtgaaaaat 652801 tggagggaaa ctcatgtcac tactgcttga accaagtaaa gaacaaataa aagaagagaa 652861 actgtatcag caaatgggtg tcagtgatga tgagtttgca ttgatagaat ccattcttgg 652921 aagattgccg aactacacag aaatcggaat tttttctgtc atgtggtctg agcattgcag 652981 ctataaaaac tcaaagccga ttctgcgtaa attcccgaca agcggcgagc gtgtgctgca 653041 ggggccgggg gaaggcgccg gaatcgttga tatcggtgat aaccaagcgg ttgtgttcaa 653101 aattgaatca cataaccacc catcagctct cgagccttac caaggcgctg cgactggcgt 653161 aggcggaatt atccgtgatg tattctcaat gggtgcacgc ccaatcgctg tattgaactc 653221 tcttcgattt ggtgaactga cttcaccccg cgtgaagtac ttgtttgaag aagtagtagc 653281 gggtatcgcc ggatacggca actgtatcgg catcccgaca gtcggcggag aagtgcagtt 653341 tgacagcagc tatgaaggaa atccgctcgt caacgcaatg tgcgtcggtt taatcaacca 653401 tgaagacatc aaaaaaggcc aggcaaaggg tgtcggcaac acagtaatgt acgtaggagc 653461 gaaaacaggg cgtgacggca tccacggcgc tacgtttgct tctgaagaaa tgtcagactc 653521 gtctgaagaa aagcgttctg ctgtccaagt cggcgatccg tttatggaga agcttttgct 653581 tgaagcatgt ctggaagtca tccaatgcga cgccttagtc ggcattcagg atatgggagc 653641 tgccggttta acaagctcaa gtgcagaaat ggcaagtaaa gccggttctg gcattgaaat 653701 gaatcttgac ctgattcctc agcgcgaaac aggcatgacc gcgtatgaaa tgatgctttc 653761 tgaatcacaa gaacggatgc ttttggttat tgagcgcgga cgtgagcagg aaatcatcga 653821 tatttttgac aagtatgatc ttgaagcggt ttctgtcgga catgtgacag atgataaaat 653881 gcttcgcctg acacataaag gagaggttgt gtgcgagctg cctgttgatg ccttggcaga 653941 agaagcaccg gtttaccata agccttctca agagcctgct tactatcgcg agtttttgga 654001 aacagacgtt ccggctccgc aaattgaaga tgcgaatgaa atgctgaagg cccttcttca 654061 gcagccgacg attgcgagta aagagtgggt ttatgatcag tatgactaca tggtgcgcac 654121 gaatacagtt gtcgctcctg ggtctgatgc tggtgttctc agaatccgcg gaacgaaaaa 654181 ggcgctggcg atgacgacag actgtaacgc gcgttatctc tatcttgatc ctgaagtcgg 654241 agggaaaatt gctgtcgctg aagcagcgcg caacatcatt tgctcaggcg cagaaccgct 654301 tgcggtgaca gataacctta acttcggaaa ccctgagaag ccggaaatct tctggcagat 654361 cgaaaaagcg gcagacggca taagcgaagc gtgcaatgtt ctcagcactc cggttatcgg 654421 cggtaacgta tcgctttata acgaatcaaa cggcacggcg atctatccga caccagttat 654481 cggcatggtc ggcctaattg aagatacagc gcacattaca acacagcatt tcaaacaagc 654541 aggagatctc gtatacgtga tcggcgaaac aaaaccagag tttgccggaa gcgagctgca 654601 aaaaatgaca gaaggccgta tttacggcaa agcgccgcaa atcgatcttg atgtagagct 654661 gtctcgtcaa aaagcactgc ttgacgcgat taaaaaaggc ttcgttcaat ctgcgcatga 654721 tgtgtctgaa ggcggcttag gcgtagcgat tgcggaaagt gtcatgacga cggaaaacct 654781 tggcgctaat gtgactgtag aaggggaagc ggcgttatta ttctctgaat ctcaatctcg 654841 cttcgtcgtt tcagtgaaaa aagaacatca agctgcgttt gaagcaactg tcaaagatgc 654901 agttcatatt ggtgaggtaa cagctgacgg aattctggcg attcaaaacc aagacggaca 654961 acaaatgatt catgcgcaaa cgaaagagct tgaacgcgta tggaaaggag ctatcccatg 655021 cttgctgaaa tcaaaggctt aaatgaagaa tgcggcgttt ttgggatttg gggacatgaa 655081 gaagccccgc aaatcacgta ttacggtctc cacagccttc agcaccgagg acaggagggt 655141 gctggcatcg tagcgactga cggtgaaaag ctgacggctc acaaaggcca aggtctgatc 655201 actgaagtat ttcaaaacgg cgaactcagc aaagtaaagg gaaaaggcgc tatcgggcac 655261 gttcggtacg caacggctgg aggcggcgga tacgaaaatg ttcagccgct cctcttccgt 655321 tcccaaaaca acggcagcct ggcgcttgct cataacggaa atcttgtcaa cgccactcag 655381 ctgaagcagc agctcgaaaa tcaagggagc atctttcaaa cctcttcgga tacagaggtt 655441 ttggctcacc tgatcaaaag aagcggacac ttcacgctga aggatcaaat taaaaactcg 655501 ctttctatgc tgaaaggcgc ctacgcgttc ctgatcatga ccgaaacaga aatgattgtc 655561 gcacttgatc caaacgggct gagaccgcta tccatcggca tgatgggcga cgcttatgtg 655621 gtcgcatcag aaacatgcgc atttgacgtc gtcggcgcaa cgtaccttcg cgaggtagag 655681 ccgggagaaa tgctgatcat taatgatgaa ggcatgaaat cagagcgttt ttccatgaat 655741 atcaatcgtt ccatttgcag catggagtac atttatttct ccagaccaga cagcaatatt 655801 gacggtatta atgtgcacag tgcccgtaaa aaccttggga aaatgctggc tcaggaatcc 655861 gcagttgaag ctgacgtcgt aaccggggtt ccggattcca gtatttcagc ggcgatcggc 655921 tatgcagagg caacaggcat tccgtatgag cttggcttaa tcaaaaaccg ttatgttggc 655981 agaacgttta ttcagccgtc ccaggctctg cgtgagcaag gcgtcagaat gaagctgtct 656041 gcggtgcgcg gggttgtaga aggcaaacgc gtcgtgatgg tggatgactc tatcgtgcga 656101 ggaacaacta gccgccggat tgtcacgatg ctaagagaag cgggtgcgac agaggtgcat 656161 gtgaaaatca gttcaccgcc gatcgctcat ccgtgctttt acggcattga cacttccaca 656221 catgaagaac tgatcgcgtc ttcgcattct gttgaagaaa tccgtcagga aatcggagcc 656281 gataccctct catttttgag tgtggaaggg ctgctgaaag gcatcggcag aaaatacgat 656341 gactcgaatt gcggacagtg tctcgcttgc tttacaggaa aatatccgac tgaaatttac 656401 caggatacag tgcttcctca cgtaaaagaa gcagtattaa ccaaataaaa cttgaaaaat 656461 gacataaagg cagcgcagtt cggctgcctt tctctttctg ccctcgttcg gggagatatt 656521 ttgaaaagcg ccttaaagga gtgaatagga tgtctgaagc atataaaaac gcaggagttg 656581 acatcgaagc cggatatgaa gctgtaaaac gaatgaaaaa acacgtggag cgcacgaaac 656641 ggcttggcgt tatgggcagc cttggcggtt ttggcggcat gtttgacctg tctgagcttt 656701 cttatcaaaa accagttctc atttcgggaa cggacggtgt cggcacaaaa ttaaagctcg 656761 ctttttccat ggataagcat gacacgattg gcgtggatgc tgttgcaatg tgtgtcaatg 656821 acgtgctggc acaaggtgca gagccgctgt ttttcctcga ttatttagcg gttggcaaag 656881 cggacccagt gaaaattgaa cagattgtac aaggtgttgc ggaaggctgt gagcagtcag 656941 gttcagcctt agtcggcggt gaaacggctg aaatgccggg gctctataca gctgatgaat 657001 acgatattgc cggtttctca gtcggagtgg cagaaaagga cgaaatcgtg actggagaaa 657061 aaattgaaga gggccatctg ttgatcggcc tcagctccag cggccttcac agcaacggct 657121 tttcccttgt cagaaaagtg cttctggatg atgcggagct ggacctcgat acaacatatg 657181 agccgtttga acgcccgctt ggcgaggaat tgcttgaacc gacaaggatt tacgtgaagc 657241 ctgtgcttgc cgcggtcaaa agcggaaaaa tcgacggcat ggcgcacgtg acaggcggag 657301 gatttattga aaatattccg cgtatgcttc cggaaggctt aagtgcggaa attgatcatg 657361 gctcatggcc gatcccgccg attttttctt tcttgcaaga gtacggcaag ctaaaggaag 657421 aagacatgtt caacgtcttt aatatgggta tcggttttgt tttggcagtc aaagaagagc 657481 atctgacaga tgtgatcgga acgcttgaaa gccatggcga aaaagcctat ttaatcgggc 657541 gtgtgaaaaa aggtgaaggc gtcacattcg gcggtgcggc actttcatga aaaagtttgc 657601 ggtatttgca tcaggaaacg gttcaaactt cgaagccatc gtcacgcgtt tgaaggagga 657661 gaactgggat gcgtcagcag cgctcctcgt ttgcgacaaa ccgcaggcga aagtcatcga 657721 acgggcggaa gcattccaca ttccatcctt cgcatttgag ccgaagtctt atgaaaacaa 657781 ggctgcattt gaacaagcca tcattgaaca gcttcgtctt cacgaggttg aattgattgc 657841 tcttgccggc tatatgaggc tgatcggtga tacgctcctt caagcatatg ggggaaaaat 657901 cattaacatt cacccatcgc ttcttccggc gtttcctgga atcgacgcag tcggacaggc 657961 gttccgggcg ggtgtgaagg tggccggaat caccgtgcat tatgtcgatg aaggaatgga 658021 tacaggtccg atcatcgctc aaaaggcaat cgaaattgat gaacatgata cattggaaac 658081 aatcgaacag cgaattcaca agcttgagca taaatggtat ccgagtgtga ttaaacagct 658141 attaggatta aataacagag gtgaaaaggc atgaccatta aacgtgcatt aatcagtgtt 658201 tcagataaaa caaatctcgt tcctttcgta aaagaactga cagagcttgg cgttgaagtc 658261 atctccacag gcggaacgaa aaagcttctt caagaaaacg gtgtggatgt gatcggaatt 658321 tctgaagtga caggctttcc tgaaattatg gacggccggt taaaaaccct acacccgaat 658381 attcacggcg gccttctggc ggttcgcggc aatgaagagc atatggcgca gatcaatgaa 658441 cacgggattc agccgattga cctcgttgtc gtcaacctct atccatttaa agaaacgatt 658501 tctaaagaag acgtcacgta tgaagaagcg atcgaaaata tcgacatcgg cggacctggc 658561 atgctgcgcg cggcatcaaa gaaccatcag gatgtcacgg ttatcgtcga tccggccgat 658621 tacagcccag tgctaaatca aatcaaagaa gaaggcagcg tatctcttca gaaaaaacgc 658681 gagctcgcgg caaaagtatt ccgtcatact gcggcatatg atgcactgat cgctgactat 658741 ctgacaaatg ttgtcggtga aaaagaacca gagcaattca ctgtgacatt tgagaaaaaa 658801 caatcgcttc gctatggaga aaacccgcat caggaagcaa ctttctatca aacagctctt 658861 cctgtcaaag gctccattgc gcaagcagaa cagcttcacg gaaaagagct ttcttacaac 658921 aacattaaag acgcggatgc tgcagttcaa atcgttcgtg aattcactga accggctgct 658981 gttgctgtga agcatatgaa cccgtgcggc gtgggaacag gaaaaacgat cgcagaagcg 659041 tttgacagag cgtttgaagc ggataaaaca tctatcttcg gcggcattat cgcgctgaac 659101 cgtgaagtgg acaaggcaac tgccgaagcg cttcacaaca ttttcttaga aatcatcatt 659161 gcgccttcat tcagccaaga agcgctcgac gtcctgactg cgaagaaaaa tctccgtctg 659221 ctgacgcttg acgtatccgc cgctgttcaa aaggaaaaac agctgacatc cgttcaaggc 659281 gggctgctga ttcaagattt agatatgcac ggcttcgatg atgctgagat tagcattccg 659341 acaaaaagag agccgaacga gcaagagtgg gaagacttga agcttgcttg gaaagtcgtg 659401 aagcatgtga aatcaaatgc gattgttctc gcgaaggaca acatgacagt cggcgtggga 659461 gcaggccaaa tgaaccgcgt cggatcggca aaaatcgcaa tcgagcaagc aggggaaaaa 659521 gcgaagggca gcgcgctcgg ttcggatgca tatttcccaa tgccagatac tgtcgaagaa 659581 gcggcaaaag cgggcgttac agccatcatt cagccaggcg gatcgatccg agatgaggat 659641 tccatcaaaa aagcggatga atacggcatt gccatggtat tcaccggcat cagacacttc 659701 aaacattaag gggatgaaaa cgacgtgaat gtattaatta tcggtaaagg cggaagagaa 659761 catacgctgg cgtggaaggc agcgcaaagc agcctcgtcg agaatgtatt tgccgctccc 659821 ggaaatgacg gcatggcagc ttccgctcag cttgtaaaca ttgaggaaag cgaccacgca 659881 gggcttgtct catttgcaaa acaaaatcag gtcggcctga ccattgtcgg ccctgaggtt 659941 cctttaattg aaggtctggt ggatgaattc gaaaaagcgg gcttacatgt gttcggtccg 660001 tcaaaagctg cggcgatcat cgaaggaagc aaacagttcg ctaaggattt aatgaagaaa 660061 tacgacattc cgaccgcaga atacgagacg tttacatcct ttgatgaggc gaaggcatat 660121 gtgcaggaaa aaggtgctcc gattgtgata aaagcagatg gacttgcagc tggaaaaggc 660181 gttactgtgg ctatgacaga ggaagaagca attgcgtgct tgcatgactt tcttgaagat 660241 gaaaagttcg gtgatgcgag cgcgtccgtt gtcattgaag aatatctttc tggtgaagaa 660301 ttttctctaa tggcctttgt caaaggggaa aaggtgtatc cgatggtgat tgcccaggat 660361 cacaagcggg cgtttgacgg agacaaaggc ccgaatacag gcggcatggg cgcctactcg 660421 ccagttccgc aaatttcgga agaaacggtc cgccatgctg tagaaacgat cgttaagccg 660481 gctgcaaaag caatggtaca agaaggccgt tccttcactg gcgttttgta cgctggattg 660541 atgcttactg aaaacggctc gaaggtcatt gaatttaatg cccgtttcgg cgatccggaa 660601 acacaggtcg tgcttccgcg catggaatct gatctggtac aggtgcttct tgatctttta 660661 gatgataagg aagttgactt aagatggaag gataccgcgg cagtgagtgt tgtgcttgca 660721 tcagaagggt atccggaaag ctatgcaaaa ggcacgccga tcggcagcct tgcagcagaa 660781 actgagcagg tcgtggtctt ccatgccgga acgaaagcag aaggtggaga gttcgttaca 660841 aacggggggc gcgtcgccaa tgtgacggct tttgatgaaa cgtttgaagc ggctagagac 660901 cgagtgtaca aagcggttga tgaaattttc aaaccgggac tctttttcag aaaagacatt 660961 ggggcacgcg ctttaaaggc tgcccaaaaa taagtgagga aaacccgcag aatagctgcg 661021 ggttttttgt tatcaaaaag cgggatggca gctagaagaa gaaagcacaa cgagcgtggt 661081 tggttttcca tgggccatcg aggtgtcaat aaaatcctca agcgtatgta ccgattcagt 661141 cacgaccttt gtcacatagc tgtacatccc cgtgatgcgg tggttttctg ctacatcagg 661201 atgcgatgtt gcaaaggcgg cgtagtgctt gcagcttttc ggctccatga gaataaaagc 661261 ggtgacatgc ttgtttagtt tttcgtaaca gatattcgcg ctgtagccgg taatcactcc 661321 tttgtcttcc agcttcctga cacgctccgc cgcgcttggc gagctgagtc cgacaagctt 661381 tcccagctca accatcgtta atctgccgtt tcgctgcaaa tgcgagagaa tctgaaggtc 661441 tgtatcgtcc atttgtctgg ctcctttaca tatttaggcg aatgaatgaa aattcctttg 661501 atcgtaaggt aatgctgttg atttaacttc attgtagcat atggatgccg tcttattttt 661561 tctataataa agccatcaat cagagagggg gcatcatgtt gccagaattg cagcgctcta 661621 ttacttggat acaagggacg gcgttaacga ttggggcggt tttaggatgc gggatattaa 661681 tcctgccgtc tgtcaccgcg gacacggccg gccccgcttc tttatttgtt tgggtgttca 661741 tgtccttctt atcctttttt cttgtcggca cgctggcccg gcttgtgaaa atagcgccta 661801 gcgcgggagg aatcacggct tatgtgcagc tggcctttca gaaaaaagcc ggggctattt 661861 tgggctggat catgttaggg tccgttccga tcggcgttcc catcatcgct ttgactggcg 661921 cgcattacgt cagttacatc acagaggcgg ccgattggca gattacattg attgctggtt 661981 gcatgctggc tatatctatt ttgcttcata tgagagggat tcaactatca gcaaacatta 662041 gtacactcgt tatatgtgtc atcgtatttc tgcttgtcac ttctattgct gtgtcattgc 662101 cacacgtcac gatagcagaa ttcaagccgt ttcttccgca tggctggtct gccgctggat 662161 ctgtttctgt tatgattttt ttctcttttg taggctggga aatgattacc ccgttggctg 662221 aggaatttca tcgtcctgaa aaagatgtcc cgctcagctt gtttttggca gcgtcttgtg 662281 tggcggggct gtatatcatg ctgtcatttg tgaccgtggg tactcattca tatggagaga 662341 atggagaaat tgcatcgctt gccatgctca tttcaaaagg agcaggagaa agcggtgtat 662401 atgtcacggt atgtttagcg ctgtttatta cattcgccac catccatgcc aatattgccg 662461 gtttttcaag aatggtgtac gcattggcga gagaggggca catacccgta ttttttggaa 662521 aactcagtgc gacaaaacgt acgcctattc gcgttttgac agcgatggcc gcagtgtttg 662581 gcttagtgct tgcagcgcat ggtctgtttc aaatcgattt gacgactctg ttgaaagggc 662641 cgagcgcggc ttttatcgca tcttacatat gtacaatggc ggcagcactg aaactgctgg 662701 gcaggagaga tataggctgg tggatggcgc tcggggcatt tgtggcgtgc gcggtgattt 662761 attcattcag cggctgggca ctgctttatc cggcagtgct ggcagctgca ggatatttct 662821 atatgaaaac aaagggtggg cataaaaaaa agcttgatca cgttttgtga tcaagctttt 662881 ccatttatcc gttttgatgc tcgttatttc cagaatcgct gtgttgaaac atgtaggtca 662941 caggacagaa gcgcaagatt cccgaacccg ctttcatggc ccccataaag atgtaaaaga 663001 gatgcattct gcaccaaggt tttttcgtaa actttgcact ggcggctgac ataatcgtca 663061 atccgcaggc gattctgaac acggcattga tgagactgat gtttggcttc aaggaaatcc 663121 gctcctttta cttaaaaaag ttttttaatc gaaccttcaa aaatttgtaa cgtttttatc 663181 gtgcgtgatg aggaaggatg tgataccatg agtctaatac atgtaaagga gagtatgtga 663241 atgtccgaac gcacctttaa ctggaaaaac aaagacatca gggcacaggt tgatgttgta 663301 gactcaaagc tgcttccaac gctcctttta cggaatgctc tcgtcttaaa tccatatgta 663361 aaacaatggc tgaaaaaaaa catttggatt tatcaggacc gcattgttta tgtgggtcat 663421 gaacttccga atagagccga agaaattcat acgattgatt gtgaaggaaa atacattgtg 663481 ccaggttata ttgaaccgca cgcacatcct tttcaaatat ataatcccca aacactggcg 663541 gaatatgtgt ctcaatacgg aacaacgaca ttcgtgaatg ataacttatt tttgcttttg 663601 caaagcggaa aaaagaaagc gcttacgatt ttgaatgaac tcaaaaagca gcctgtccag 663661 tatttttggt ggtcacgcta tgacctccag accgaggttc tgaacgagga ccacgtcctt 663721 ccatttgacg tcagaaaaca gtggattgaa catccggatg tgattcaagg cggagaaatg 663781 accggatggc ctcgcctggt agatggtgat gatttaatgc tccactgtat gcaagctaca 663841 aagaaacaga gaaaacgtat tgaagggcat tttcccggcg cttctgataa aacgcttaca 663901 aaaatgaagc tgttcggtgc ggattgtgat catgaagcga tgacaggtga tgaagtgatg 663961 agaaggctgg aactgggcta ttatgtttcc cttcggaact cttccattcg ccccgatgta 664021 agaaaaatct tgcaagagct gcatgagaag ggcttccgct attatgacca cttcttttac 664081 acgacagatg gcgcaacccc gaatttctat aaaggcggca tgacaaacga gctgattcgc 664141 attgcgttag aagaaggcgt acctgcaatc gacgcctaca atatggcatc atttaatatc 664201 gcaaagtatt accaaatgga tgattattta ggagttgtcg gaccgggcag actggcatcg 664261 ctaaacatac tggaagatcc gttaaatccg aatccagtga ctgttctgtc aaaagggacc 664321 attctgcgtg aaaacggctg tgatttgaag gcgtttacaa agacggactg gcacaaaggc 664381 ggtcttgtcc cgcttgagct ttcatatgat atgacgatgg atgacttgca gttttctatg 664441 ccgatgggcg tgaaaatgcg gaatgcggtt attatggagc catatatgat tgagatcgac 664501 aattcgatgg aacagctctc gtttgaccat gatgaaagtt atttgacgat gctcgacaga 664561 cacgggaaat ggcgcgtcaa tacgatgata aaagggtttg cctcaagcgt gcagggattt 664621 gtaagctcct ttacgacgac gggcgacatt gtcgcgattg gaaaaaataa agcggatatg 664681 ctgctcgctt tcgcccgcat gaaagaaatc ggaggaggaa ttgttttagc ggagaacgga 664741 aacattctgc atgaaatccc gcttgcgctg tgcggctgcg cctcttcgga agcgtatgaa 664801 gacgtgcttg agaaggaaca aaagctgaga gatcttttga ctgaaagagg ctatgagttt 664861 tgcgatccta tctatacgct gctctttttg caaagtacgc accttccgta tatacgcatt 664921 acgccaagag gaatattcga cgtcatgaaa aaaactgtac tctttccatc gataatgcgt 664981 taaaatataa aagagcaggg agccgacata tgaaaaaatg gatgacagtt tgcgcgctgt 665041 gtttcgtgtt ttttctgctg gtatcctgcc agcagaagga tgctgtcccg gatactgcaa 665101 agaagctgaa agctccttta acggggctaa agactgaaca gaaagtgact gaacgccgcc 665161 ctgttgctgt tgtggtgaac aatcacccga aggcgaggcc gcagtcgggt ctgtctaaag 665221 ccgacattgt catagaagcg ctagccgaag ggcaaatcac aagatttctg gccattttcc 665281 aaagccagat gcctgaaact gtcggacctg tgcggagcgc gcgggaatat ttcgtcactc 665341 tcagcaatgg ctttgacagc atatttgtcc atcacggctg gagtcccggc gccaaaaagc 665401 agctggaatc cggagctgcc gattatatga acggattgga ttttgacgga agcttatttt 665461 ggagagctga tttcagcaaa ccgccccaca attcctatac gtcttatgat tacataaaaa 665521 aggcggcaga acaaaagggt tataagctga agcaggaaac aaatccgctg ctgtttcaaa 665581 catcagatgc aaaacctgca aatgaatctt acaatgttcg ggtagattat ggaacaaata 665641 acgttacaaa tcttgtcgaa tacaactatg ataaaaaagc tgaattttat acaagaagct 665701 ctgatggtgt cataacgaca gaccgggaaa ccggaaagcc ggttgcaatg caaaatattt 665761 tcattgttga agccagccat catattattg atcaagatgg aaggcgggac atcgacttgg 665821 aatcaggagg aaaaggtctg ttgtttcagc acggaaacgt cattgaaaca gactggaaac 665881 aagtgaatgg cagaattgtg ccggtaaaag acggcaagtg gcttccgttt gtgccaggaa 665941 agacttggat caatatcgta cctgatcttg atgcggcttc cattagtaaa ggagaaggtg 666001 tgtaacgatg caaatcgata aattacgcgg caaagagctg gaccagttat ttaactcgat 666061 cttatcgctg aaagacctgg aggaatgtta ccgattcttc gatgatctat gcacaattaa 666121 cgaaattcaa tcgctggctc agcgccttga agtggcgcgc atgcttcgcg aaggaaacac 666181 gtatcataag attgaaacag aaacaggcgc ttccacggct acgatttccc gtgtgaaacg 666241 ctgcttaaat tacggaaatg acgcttatga aatggcgctt gaccgtgtga aggagacgga 666301 aacagagtct tcttccaaat aaaaaaccgc cctgccgtct ggcaagggcg gtttctttat 666361 gaaacaaatt gatggatcag gttgtcgata ttgatgatac tgccatcctc tttccgatag 666421 acaacatgct ccttggaaaa atgaatcggc gaattaatcc ctgctgcggc tgcaaggtta 666481 aatagtccct cgcgcaatga aataacgtag ttgcagacac gatgctgttt ttcctcaacg 666541 ctcagtgctt tttgcaattt cggatctgtc gtcgccacac ctgccggaca ggtgttggtg 666601 tggcagacga gagcgcggat gcagccaacg gaaaacatca tgccgcgtgc gatgttaaca 666661 aagtcagcgc cgagggctaa ggcgaccgcg attttatcag gagtcaggag ctttccggaa 666721 gcaaagattt tcagctggct gcgcaagccg tactgtttaa gaagcgtgtc cacaataggc 666781 agcgctgtca taatcggaag gccgactgta tccgcgagct cgtaaaagga agctccggta 666841 ccgccttcac ttccgtcgat cgtgataaaa tccggatgct ttccgctttt ctgcatatga 666901 gagaaaagct catgcaattc ttcaggatgc cctgcgacca gtttgatgcc gactggcttt 666961 tgtccgacat ctctaagttt ttcaataaag tcgagcattt caggagggtt tgagaattca 667021 taaaagcggt tcgggctgtc aatcgacttt ccaggttcga cattccgaat gtctgccact 667081 tcctctgata ctttggcgcc gtccacatgg ccgccgcggg ttttcgctcc ttgtgccagc 667141 tttagctcaa acgctttaat ctggtcaatc ctgctttttc ttttaaattc ctcccacgaa 667201 aattccccgt ttcttttgcg cacgccgaat aggcccggtc cgatttggca aatgatatcg 667261 gcgccgccct ttaagtgata ttcagacaat cccccttcac ctgtattcat ccaggtgccg 667321 cctgccagat ggagcccttt tgagagcgcc gtaacagccc gttctccaag agaaccgtag 667381 ctcatggcag actggccgac taagcccttc acataaaatg gcttctcgca tgtatgctcg 667441 ccaatcacct gtacatcatc aggatggaga aaatacgggt ctgccttgat atgttcggca 667501 tgctccttgc gtttgaacag attgtcagca tccattttat agatttgggt ttcaattttt 667561 ggcgtttgat ttacatgcat ttcttccctt tgttttggaa acatagcgtt acggatataa 667621 tagccaggtt tatcaaaatc tcttacagat ccaaagccca tcattctgct tttgtatttg 667681 ccggagatga cggtttgctc atattccttt cgtgaaaatg gctgctcttc attgtcattg 667741 ctgtataaat actgtctgag ctccggcccg attttttcaa ggatataccg aaaccttccg 667801 atgacgggat agttgcgaag aattgagtgc tcctgctgtt tttcatcctt tatgtagatc 667861 caggcaaaca agacgatcgg gatagcgatg atcccaatga taaatgcgat gagtgctatt 667921 atgatggttt ccatctctca gcctcccttt ttatgtaacc atttccacag tagaacactt 667981 tccaaacaat agcagaagga atctggtgaa aaatgtgtgc tcctgccgat acaggactca 668041 ccatgcaggt actgccatat gctctctttt tttatgaaaa aagaatcaaa acaccttttt 668101 cagtgaataa cgagattaac ggctttttcc gtttttccgc gctatgtgaa tttgttataa 668161 tgtttaaatg gtaacaaacg aatggaggaa cgtatgacgt gtacgatgta acggagtgga 668221 agcatgtctt taaactcgat ccaaataaag atttgcctga cgaacagctg gagattcttt 668281 gcgaatcagg aacggatgcg gtcattatcg gaggaagcga tggtgtgaca gaggataatg 668341 tcctgcggat gatgtctaag gtaagacggt ttttggtgcc gtgtgtccta gaggtatcag 668401 cgattgaagc gattgttccc ggctttgact tatattttat tccgagtgta ttaaacagca 668461 aaaacgcgga ttggattgtc ggaatgcacc agaaagccat gaaggaatac ggagaactga 668521 tgtctatgga agaaatcgtg gcggagggct actgcatcgc aaatccagat tgcaaagccg 668581 cggcactgac tgaagcggac gccgatctga atatggatga tattgtcgcc tatgcgcgtg 668641 tgtcggagct gctgcaactg ccgatttttt atttagaata cagcggcgtg cttggagaca 668701 tagaagctgt caagaaaacg aaggctgtat tggaaacgtc caccttgttt tacggcggcg 668761 gcatcaagga tgcggaaacg gccaagcagt acgcagagca tgcggacgtg atcgttgtag 668821 gcaatgcggt gtatgaagat tttgacaggg ctttgaaaac agtagcggct gtgaaaggcg 668881 agtagtaaat tgtacggatt tggtttatga tagaacgtat gttttgtata ggcgggtgaa 668941 caaattttga attatattag caatcaatta ctaagcggtt taaaccccgt tcagcaggaa 669001 gcagtcaaaa caacggacgg gcctcttttg ctgatggcgg gagcgggtag cggaaagacg 669061 cgtgtcctga cccatagaat tgcttattta atggcagaaa agcatgtggc gccgtggaac 669121 attctggcga tcacatttac aaataaagcg gcacgcgaaa tgaaagaacg tgtggaaagc 669181 atcctcggac ccggcgcgga cgatatctgg atctccacat tccacagcat gtgcgtgcgg 669241 atcttgcgca gagatatcga ccggattggg atcaaccgaa atttctccat ccttgatacg 669301 gctgaccagc tttcagtgat caaggggatt ttgaaggagc gcaatcttga tccgaagaag 669361 tttgacccga gaagcatcct cggcacgatc agcagtgcaa aaaacgaatt gaccgaaccg 669421 gaggaattct ctaaagttgc tggcggctac tacgatcagg tggtcagcga tgtatatgct 669481 gattatcaga agaagctatt gaaaaaccag tcgctcgatt tcgacgattt aattatgacg 669541 acgattaaac tgtttgacag agtgcctgaa gtgcttgaat tttatcagcg caaattccag 669601 tacatccacg ttgatgagta tcaggatacg aacagggcac aatacatgct cgttaagcag 669661 cttgccgagc gtttccagaa cctttgcgtt gtgggggatt ctgatcagtc aatctacaga 669721 tggcgcggcg cggatatcac caacattctt tcatttgaaa aagattatcc gaatgcaagc 669781 gtgattttgc tagaacaaaa ctatcgttca acgaaacgga ttttgcgcgc ggctaacgag 669841 gtcattaaaa acaactctaa ccgcaaaccg aaaaatttgt ggacggaaaa tgatgaaggc 669901 atcaagattt cctattatcg cggtgataat gagttcggtg aaggacagtt tgtggccggc 669961 aaaattcatc agcttcacag cacaggcaag cggaagctgt cggatatcgc catattatac 670021 cggacaaacg cgcagtcccg tgtgattgag gaaacgcttc tcaaagcggg cttgaactat 670081 aacattgtcg gcggcacaaa gttctatgac agaaaagaaa ttaaagacat tcttgcgtac 670141 ctgcgcctcg tatccaatcc ggatgacgat atcagtttca cgcgcattgt caatgtgccg 670201 aagcgcggag tcggcgcgac atcacttgaa aaaatcgctt cgtatgcggc cataaacggc 670261 ttgtcctttt tccaagcgat tcagcaggtt gattttatcg gcgtcagtgc caaagcggca 670321 aacgcgcttg acagctttag acagatgatt gaaaacctga ccaatatgca ggattactta 670381 tccattacag agctgacaga agaaattctt gataagacgg aatacagaga aatgctgaag 670441 gctgagaaat cgatcgaagc ccaaagccgt ttagaaaata tcgacgagtt cctgtctgtt 670501 acgaaaaact ttgaacagaa aagtgaagac aagacactcg ttgcgttcct gacagacttg 670561 gcattgatcg cagatattga tcagctcgat cagaaggagg aagagtcagg cggcaaggat 670621 gcgatcaccc tgatgacact gcacgccgcg aaaggactgg agtttccggt tgttttcttg 670681 atggggcttg aagaaggcgt cttcccgcat agccgttcac tcatggagga agcggaaatg 670741 gaagaagaac gccgccttgc gtacgttggg attacaaggg cggaacagga gctttatctg 670801 accaatgcta aaatgcgcac cttgtttggc cggacaaata tgaacccgga atctcgcttc 670861 attgctgaaa taccggatga tttattggaa aacctaaatg agaaaaaaga aacaagagcg 670921 acgtctgcga gaaaaatgca gccgagacgc ggccctgttt cacgcccggt atcctacgcc 670981 agcaaaacag gcggcgacac cttgaactgg gcagtcggag ataaggcggg ccataaaaaa 671041 tggggaacag gaactgtcgt cagcgtgaaa ggcgaaggag aagggacaga gcttgatatt 671101 gccttcccga gccctgtcgg cgtgaaacgc ctgttagcag catttgctcc tattgaaaag 671161 cagtaattga agaggaaagg aagaagcaga tggacaaaga aacagcgaag cagcgggcag 671221 aagaactgcg ccgcaccatc aacaagtata gctatgaata ttacacctta gatgaaccga 671281 gcgtcccaga tgccgaatac gacagattga tgcaggagct gatcgcgatc gaggaggagc 671341 acccagacct cagaacgcct gactctccta cgcagcgcgt cggcggagcc gtgcttgaag 671401 cgtttcagaa agtcacccac ggcacaccga tgctcagtct gggcaacgcc tttaatgctg 671461 atgatcttcg tgatttcgac cgccgtgtgc gccagtccgt cggcgacgat gtggcgtata 671521 atgtggagct gaaaatagac ggtcttgctg tttctctccg ttatgaagac ggctattttg 671581 tcagaggggc cacaagaggt gacgggacga cgggagagga tatcacggag aatctgaaga 671641 cgatccgcaa tatccccctt aaaatgaacc gtgagctgtc gatcgaagtg cgcggcgagg 671701 cgtatatgcc gaagcgttcg tttgaagcac tcaatgagga acggattaaa aatgaggaag 671761 aaccgttcgc caatccgcga aatgccgcgg cgggatctct cagacagctc gatccgaaaa 671821 ttgcagcgaa acgaaacctc gatatcttcg tctacagtat agcggagctt gacgagatgg 671881 gtgtagagac gcaaagccaa gggcttgatt ttctcgacga actcggattt aaaacgaatc 671941 aggaacgaaa aaaatgcggc agcatagaag aagtcattac gctgatcgat gagcttcagg 672001 cgaagcgcgc ggacctgccg tacgaaatag acggcattgt cattaaagtc gattctctcg 672061 atcaacagga ggagctcggt tttacggcga aaagcccgcg ctgggccatc gcgtataagt 672121 ttcctgctga agaggtcgtg acgaagcttc tcgatatcga attaaatgtc ggcagaacgg 672181 gtgtgattac gccgactgcg attcttgagc cggtaaaagt tgccggcaca acggtctcaa 672241 gagcatccct tcataacgaa gatttaatta aagagaagga cattcggatt ttggataagg 672301 ttgtcgtcaa aaaagcgggc gatatcatcc cggaagttgt gaatgtcctc gttgaccagc 672361 gcacaggaga agaaaaggaa ttcagcatgc cgacggaatg tcctgaatgc ggcagtgaac 672421 tcgtccggat cgaaggagaa gtggcgcttc gctgcattaa ccctgaatgt ccggcgcaaa 672481 tccgggaagg gcttatccat ttcgtttccc ggaatgccat gaacattgat gggctcggcg 672541 aacgagtgat cacacagctg tttgaggaaa accttgtccg caatgtggca gatttatata 672601 agctgacgaa ggaacgagtc atccagctcg agcgcatggg cgaaaagtcc actgaaaacc 672661 tgatcagctc catccaaaaa tcaaaagaaa attcgttaga gcgcctgctg tttgggcttg 672721 gcatccgttt tatcggatca aaggccgcaa agacgcttgc catgcatttt gaaagcttgg 672781 agaacctgaa aaaagcctct aaagaggaac ttctcgcggt agatgaaatc ggtgaaaaaa 672841 tggctgatgc tgtgatcacc tattttcata aagaagaaat gcttgaactc ttgaatgaac 672901 ttcaggagct gggcgtaaac acgctctaca aaggcccgaa aaaagtaaaa gcagaggaca 672961 gcgactctta ctttgctggt aaaacaattg ttctgacagg aaagctggaa gagctgtcaa 673021 gaaacgaagc caaagcgcaa atcgaagcgc tgggcggaaa gctgactgga agcgtcagca 673081 aaaacacaga cttagtcatc gccggagaag cggcgggaag caagctgaca aaagcacaag 673141 agctgaacat tgaagtgtgg aatgaagaac agttaatggg agagctaaag aaataagagg 673201 agtgttttct attgaaaaag acgttggcat tggcggcaac ggcggcagta ttaatgctgt 673261 ctgcctgctc gtcaggtttc gggggggaga aggaggaaga gattacgcaa aagacggcga 673321 aatcgtcaga aaaagcgatt gtcccgaaat ataatatctc tgactcctat tacaaaatgg 673381 tgctgccgtt taaggcaggc aaagcgcgcg gcttaacaac ggaacagctg aatacaaggc 673441 tggacattga cgaatttgaa acagggctga tgcgccttgc ccaagattct ttctcaactg 673501 acgattatct gttccaagaa ggacaatatt tagatgagga tacagtatta agctggctgg 673561 cacggaaaaa aacgggctct gatttgaaaa aagccgaaaa agaagataag aacttcaaaa 673621 atgaaggctt gaacccggcg ctcccgagtt ctggttcaac agaagaaaag aacgaaagca 673681 gcccaattta tttagcatcc atgcttgagc acgattattt agtcagaaaa gacaagaatt 673741 ctatccagct tggcggcgtc atgatcggac tggcgttaaa ctcagtgtat tactatcgtg 673801 aaaaaactgg cgacccgcaa aaagaagtgg agattaaaga cagcacgctt cgccagcagg 673861 gagaaaaaat tgcacaggag gttattaacc gcctccgcaa aaaagataac ttgaagaatg 673921 tgccgattac cgtggcgctc tacaagcagg cgtcaaaaac atcgattgtg ccggggaact 673981 tcatcgccaa aacagaggtc aaagcaggct ctactgatat ctcaaattgg gatgacatca 674041 atgaaaaata tgtattctat ccggcggata caaccacagc agaaaagtac ccggatgaca 674101 ccgaggtctt taagcggttc aaaaactcaa ttgaagaata tttcccgaac tatacaggcg 674161 ttgtcggtac agcgctgtat gaaaatgatg aaatgaagaa aatgaagatt gacataccaa 674221 tgcaattcta cggaaaaagt gaagttgtcg cgtttaccca gttcttaacg ggtgaagtga 674281 tggactacta ctctaagagc tcagttgatg tcgaagtcaa tatcacgtcc tcagacggac 674341 aggaagcggt cattatccgc aatgccggag ataaagagcc gactgttcac atttatgact 674401 gatagaaaac ccttgtgcca tattggcaca agggttttta tgttacaatt aacaggaaaa 674461 gggaaaatat tttcacttct gccgaaacac aaatcaaggg gaggtatgtt gatgctggaa 674521 atcgtgtgaa aacaatcatt atcaaatcta tagcaatgaa aggatgttag acgtgcataa 674581 agatatcaaa aaaatatttc atgaagagca ggttttggca gaagctgcag cgagatacgg 674641 tttctcaaaa gatcaggtgc gttttctggc tgatgcggaa aactatgtat atgaatgtat 674701 gaaagacaat caaccttata ttttaaagat tacccatacg attcggagat cttctgatta 674761 tatgatggga gagatggaat ggctccgtca ccttgcaata gggggaattt cagtagccaa 674821 accgctcccg tcgctgaacg gaaaagacgt agaagcagtg ccggacggaa acggcgggtc 674881 atttttattg agagtgtatg agaaagcgcc ggggcaaaaa gtggatgaat cggactggaa 674941 tgaaacgcta ttttatgagc ttggcagata cacaggcagc atgcacagcc tgacaaaaag 675001 ctacaaattg agcaatcccg ctttcaaaag acaggaatgg gatgaagagg agcaattaaa 675061 gctgagaaaa tatgtgcctg aagatcagat aaaggtgttt cagcaagccg attctttgat 675121 gaatgaactg cggaggctcc cgaaaagcca ggacaactac ggcttggtgc atgcggatct 675181 gcaccatggc aattttaact gggatcatgg caaaatcacg gcatttgatt ttgatgatat 675241 cggctacaac tggtttgtta acgatattag cattcttctc tacaatgtcc tgtggtatcc 675301 tgttgtgcca tatgatgata aagctgcgtt tacagaagaa tttatgacgc attttatgaa 675361 agggtactgg gaggaaaatg agcttgaccc tgcatggctg atgataatac ctgatttcct 675421 ccgccttcgc catatgctga tttacggatt gctgcatcag atgtttgacc ttaacacaat 675481 aggagaagag gaaaaagaaa tgctggccgg tttcagaaga gatatagaga atggcacgcc 675541 gattacagca tttgattttt cagcactggt gtagatagaa aaagccaatg ggattccagt 675601 cccattggct tttataatgt atcacacttc acgccgacta cgccttcaat ggctttaatg 675661 tcatagtaga catcggtcgt gtatctgttt ttatggacgc ggaccttcac ttccataatt 675721 ggaaaatcct tttcgcctag gtcgtcgatc cgaacggagt gtgctttgat atctcttctt 675781 ttcatttctt ttaaaatctc tgtcattttg tctttatcag aaagtgacat tctgatgcgg 675841 atgtcttttt cctgcaggcg gtcggggccg atttttctga ccacccatgg gagaaattcc 675901 acactgatca ggatgaacag aagactggca aacgcttctt tataaaaacc ggctcccgta 675961 gcaagcccga gccccgctgc cccccagatc atggccgatg tcgtcaggcc ggaaatgaca 676021 tcattgcttt ttcgcaggat gacaccggcg ccgataaacc cgacgccgga gatgatttgt 676081 gccggcagac gaagcggatc catcatgatg cggtagtatt tagggaaatg atatgccgca 676141 ttaatactga cgatcgtcag catgcatgag ctgactgcga tgacaataca ggtttttaat 676201 ccgagcggct tattttttaa ttcgcgttca agcccgatga ccatgccaat caatgtggca 676261 atgcccaatt tcaataaaat atcaggatca atataccagc tcaacagcaa acttccccct 676321 tctctatggt gtttttaaat aaatatgatt ttctcacagt atttatagca aaacaagagc 676381 acaaaagcca ccaagctgcg cttgatggct tattgcttac tttttgcgtt ttaacagctt 676441 ttccatgaca ccgaataatc ggtaagaggc ttttgcagga cgttttgtga tcatgctgac 676501 aatgatgccg gcaatcatac tgagaataaa cccagggatg atttcgtaca caccggttga 676561 ttttgccagg ccggttgtaa tccagatcaa cacggtcgca gccccgacaa tcatggcagc 676621 aagcgcgccc cattcgttca ttcgtttcca atacagactg agcagaatcg caggcccgaa 676681 agctgaaccg aagccggccc aagcgtatcc gaccaaatca agaatggtgc tgttcgggtt 676741 caatgacaag agtaccgcga taacggcaat gactaagacg gacaatcgcc cgatcatgac 676801 caattcttta tcagaagctt ttcgtctgaa aaatgaccgg tataaatcct ctgttacagc 676861 acttgctgtg accaagagct gtgaggaaat cgaactcatg atggcagcca aaatagctga 676921 caataagaac cctgtaatta atgggtggaa caagatttta gagaagataa tgaaaatcat 676981 ctccggatct tttacagcaa ctccgaattt atgggcgtat gcaacaccga ttaaacccgt 677041 cagcacggaa cctagaactg taatgatcat ccagctcatg ccgattcggc gtgcaggttt 677101 taaatcttta atgtctttaa tggccataaa tcggacgatg atatgaggct ggccgtagta 677161 gcccaacccc caggctaaat aggaaataat gctaatgacg ctcgcgcctt taaaaatatc 677221 caataaatgt ggattaacag cgtcgatttc atggaaagtc ggagcaacgc cgcccacatg 677281 ggtaaaagca acgatcggca caagcactag tgctgcaaac atgatcgcac cctgcacgaa 677341 gtcagtcaga ctgacagcaa ggaaaccgcc aaacagtgtg tataacacga caactgcggt 677401 ggtcagaaac aggcctaatt tgtaatccgc accaaaagca gattcaaaca gccgtccgcc 677461 agataccata ccggaagagg tatacaatgt gaaaaagatc atgatgatca atgcagatac 677521 gattttcagc agtgatgaag aatgctggaa tcgtttatca aagaaatcag gaattgtaat 677581 cgcatcatct gccgcttctg tataagcacg cagccttgga gccagcagca agtaatttga 677641 gtacgccccg attgtaagac ctaaagcaag ccataaggtg gacagccctg tcgcaaacat 677701 cgcgccggga acacccatca gcatccatcc gctcatatcg gccgcgccgg cagacaaagc 677761 agtaacgaat ggtccgaggc ctcttcctcc aagcatgtaa tcattgatgt cagtggtttt 677821 cttgaatgca taccagccga ttaacagcat ggcaataaag taaattccta aagatataat 677881 aatttcaata ctcacgtttt accctctctt catttctaat aatgttgcat cacctctcaa 677941 attgatggtg ccagttaagc agcctggcgt aagtgcaaaa caaaagaaat tcttttgcgg 678001 gtgcacttgg taacttaacc taacaaagta ttcccggcca ttcaagcgat gaaacattga 678061 tcataagctg gaaataccgt tgcaaaccta gaagggaata aagaataaaa cgctttcaaa 678121 aaataattaa agtaaaaata ttcagaaaaa tatttcgttt ctccttctcc tcattttagt 678181 ataaaatata tagggtattg tttcgaaaac acaggcctgt ctcaaggcgt tttgttgctt 678241 taaagggctt gtttttgata tgatcagtat tatatgactt aacggagaaa tatgtggagg 678301 tggatcatat gtcacgaatt tcaatagaag aagtaaagca cgttgcgcac cttgcaagac 678361 ttgcgattac tgaagaagaa gcaaaaatgt tcactgaaca gctcgacagt atcatttcat 678421 ttgccgagga gcttaatgag gttaacacag acaatgtgga gcctacaact cacgtgctga 678481 aaatgaaaaa tgtcatgaga gaagatgaag cgggtaaagg tcttccggtt gaggatgtca 678541 tgaaaaatgc gcctgaccat aaagacggct atattcgtgt gccatcaatt ctggactaaa 678601 ggagggacac aagaatgtca ttatttgatc ataaaatcac agaattaaaa cagctcatac 678661 ataaaaaaga gattaagatt tctgatctgg ttgatgaatc ttataaacgc atccaagcgg 678721 ttgatgataa ggtacaagcc tttttggcat tagatgaaga aagagcgcgc gcatacgcga 678781 aggagcttga tgaggcggtt gacggccgtt ctgagcacgg tcttcttttc ggtatgccga 678841 tcggcgtaaa agataatatc gtaacaaaag ggctgcgcac aacatgctcc agcaaaattc 678901 tcgaaaactt tgatccgatt tacgatgcta ctgtcgttca gcgccttcaa gacgctgaag 678961 cggtcacaat cggaaaactg aacatggacg aattcgccat ggggtcatct acagaaaact 679021 cagcttacaa gctgacgaaa aacccttgga acctggatac agttcccggc ggttcaagcg 679081 gcggatctgc agctgcggtt gctgcgggag aagttccgtt ttctcttgga tctgacacag 679141 gcggctccat ccgtcagccg gcatctttct gcggcgttgt cggattaaaa cctacatacg 679201 gacgtgtatc tcgttacggc ctggtcgcat ttgcgtcttc attggaccaa atcggaccga 679261 ttacacgtac ggttgaggat aacgcgtttt tacttcaagc gatttccggc gtagacaaaa 679321 tggactctac gagtgcaaat gtggacgtgc ctgattttct ttcttcatta actggcgaca 679381 tcaaaggact gaaaatcgcc gttccgaaag aataccttgg tgaaggtgtc ggcaaagaag 679441 cgagagaatc tgtcttggca gcgctgaaag tccttgaagg tctcggcgct acatgggaag 679501 aagtgtctct tccgcacagt aaatacgcgc ttgcgacata ttacctgctg tcatcttctg 679561 aagcgtcagc gaaccttgca cgctttgacg gcatccgcta cggctaccgc acagacaacg 679621 cggataacct gatcgacctt tacaagcaaa cgcgcgctga aggtttcgga aatgaagtca 679681 aacgccgcat catgctcgga acgtttgctt taagctcagg ctactacgat gcgtactaca 679741 aaaaagcgca aaaagtgcgt acgttgatta agaaggattt cgaggacgta tttgaaaaat 679801 atgatgttat tgttggaccg actacaccga cacctgcgtt taaaatcggt gaaaacacga 679861 aggatccgct cacaatgtac gcaaacgata tcttaacgat tccggtcaac cttgccggcg 679921 taccgggaat cagtgtgcca tgcggattag cagacggact tccgctcggc ctgcaaatca 679981 tcggaaaaca ctttgatgaa agcactgtat accgcgttgc tcatgcattt gaacaagcaa 680041 cagaccatca taaagcaaaa cctgaactgt aaggggtgaa aagaattgaa ctttgaaacg 680101 gtaatcggac ttgaagtcca cgttgagtta aaaacaaaat caaaaatttt ctcaagctct 680161 ccaacgccat tcggcgcgga ggcgaatacg cagacaagcg ttattgacct cggatatccg 680221 ggcgtcctgc ctgttctgaa caaagaagcc gttgaattcg caatgaaagc cgctatggcg 680281 ctcaactgtg agatcgcaac ggatacgaag tttgaccgca aaaactattt ctatcctgac 680341 aacccgaaag cgtatcagat ttctcaattt gataagccaa tcggcgaaaa cggctggatc 680401 gaaattgaag tcggcggcaa aacaaaacgc atcggcatca cgcgccttca tcttgaagag 680461 gatgccggaa aactgacgca tacgggcgac ggctattctc ttgttgactt caaccgtcaa 680521 ggaacgccgc ttgttgagat cgtatcagag ccggacatcc gcacgccgga agaagcgtac 680581 gcatatcttg aaaagctgaa atccatcatc caatatacag gcgtttctga ctgtaaaatg 680641 gaagaaggct cacttcgctg tgacgccaat atctctcttc gtccgatcgg ccaagaggaa 680701 ttcggcacaa aaacagaatt gaaaaacttg aactcctttg cgtttgttca aaaaggcctt 680761 gagcatgaag aaaaacgcca ggagcaggtt cttctttccg gcggcgtcat ccagcaagaa 680821 actcgccgtt atgatgaagc aacgaagaaa accattctta tgcgtgtcaa agagggatct 680881 gacgactacc gttacttccc agagccagat ctagtcgagc tctacattga tgatgaatgg 680941 aaggaacgcg taaaagcaag cattcctgag cttccggatg agcgccgcaa gcgttatatc 681001 gaagagcttg gcttgcctgc atatgacgca atggttctga cgctgacaaa agaaatggct 681061 gatttcttcg aagaaaccgt tcaaaaaggc gctgaagcta aacaagcgtc taactggctg 681121 atgggtgaag tgtcagctta cctaaacgca gaacaaaaag agcttgccga tgttgccctg 681181 acacctgaag gccttgccgg catgatcaaa ttgattgaaa aaggaaccat ttcttctaag 681241 atcgcgaaga aagtgtttaa agaattgatt gaaaaaggcg gcgacgctga gaagattgtg 681301 aaagagaaag gccttgttca gatttctgac gaaggcgtgc ttctgaagct tgtcactgag 681361 gcgcttgaca acaatcctca atcaatcgaa gactttaaaa acggaaaaga ccgcgcgatc 681421 ggcttcctag tcggacagat tatgaaagcg tccaaaggac aagccaaccc gccgatggtc 681481 aacaaaattc tgcttgaaga aattaaaaaa cgctaataaa aaagcagccc ttagaggctg 681541 ctttttttat ggtcaaattg agataaagac aagatgaggg cccgaagcct ttcaacttct 681601 ttgtcgttgg ttccggccaa attggacagc atgcctttaa taatcggctt gcgcggttta 681661 tcctgagtca attcttcctc gataacatca agtgacacgg tgatatcctc gggcagcgtg 681721 ctgttttctt tcactttctg aatgtcctca agcagctggt cttttcccgc aggcatcggg 681781 ttaaaaatgt cttttgatac aatcggattg agtgcagaac ggctcagccc ctgtacaaga 681841 tcatccagtc tctcaataat aaaggctgag atttcttctg catcgatatt aagctcaccg 681901 ttaaatacca tcacgttcat ataggaatgc acaatgcctc ttgccatgat ggacagatct 681961 gcgacatacc gctcgattcc ttcgccatag gataccagca aggcgttccg gtacagctta 682021 tccgtctcca tggttacttt gtaaaagtat tgcttgattt cttgattttc cggaatgata 682081 ttttcggtaa gcaaaagaac gataaaatct ttatgatcgc gaaaatcctc aaattgagcg 682141 ccaatttgct tttttaacac ttccttaggc ggctttccgg cgagatcttc ttctatattt 682201 ttcattttgt tcatagacat accgatataa tattcacagg cagataacag cagcgcttct 682261 ttcgatttga agtgcaaata aaaagcgccc ttcgaaatgc cgcattcact ggcgatttct 682321 tggatcgtcg tagctgcgaa tccttttttc gcaaataaac gaatgctggt ttttatgatt 682381 ctctcttttt tttcattcat gacgtgcttc cccttaatcc ttgaaaaatt tagtaaaatt 682441 ttctggtata tgagttgacg ttgttgcgtt ataacgttta gtattatata gaatgaccag 682501 tcagtcaata aaaaatgtaa tggaggatat gatgaaccac gttattaatt tcgttctgaa 682561 aaacaaattc gccgtatggc tgatgacgat tattgtaacg gcagccggct tgtatgcggg 682621 tatgaatatg aagcaagagt ctattcctga cgtgaacatg ccttacttga cgatcagcac 682681 gacatatccg ggtgcaacac caagccaagt ggctgatgaa gtgaccaaac cggttgaaca 682741 agccgtacag aacttggacg gtgtcagcgt tgtgacgtcg acgtcctatg aaaacgcatc 682801 gtcggtcatg attgaatatg attatgagaa agatatggac aaagcgaaaa cagaagcagc 682861 tgaagcgtta gaaaacgtca acctgcctga tgacgcgaag gatccggaga tttcacgcta 682921 cagcttgaac tcattcccga ttctgacgct gagcgtgtcc agtgataaag ataatctgca 682981 agagctgacg aaacaagtgg aggacagcct cgtttctaag cttgaaggca tagaaggcgt 683041 tgcgtccgtc caagtatcag gccagcaggt ggaagaggtt gaattctctt tcaaagaaga 683101 caaactgaag gaatacggcc ttgatgaaga tacagtcaag caagtgattc aaggttcaga 683161 tgtgacaact ccgcttggat tgtacacatt cggaaatgaa gaaaaatctg tcgtcgtcag 683221 cggcgatatt gaaacaatta aagatttgaa gaatatgaga atcccgacgg catctgcttc 683281 aagtgcaggc agcagcgcag catctcaagc aggtgcgcag agtgctcaag cagcccaaag 683341 cgcgcaagcg gcagcacagg tgcagcaaag cgcaagcaca gcagtgccga cggtcaagct 683401 ttctgacatt gctacaatta aagatgtgaa aaaagctgaa tccgtttcac gcacaaatgg 683461 caaagacagc atcggcatca acatcgtcaa agcaaacgat gcgaatacgg tagaggttgc 683521 cgacgatgtc aaagctgagc tgaaaaagtt caaagaagac cataaaggct tcaattacag 683581 cgcaactctc gacatggcgg agccgatcac acagtcagtt gacacgatgt taagcaaagc 683641 catcttcggt gctatttttg cgattgtgat tattctctta ttcttaagag atatcaaatc 683701 aacattaatt tctgttgttt caattccatt atcattgctg atcgcactcc ttgtgctgca 683761 gcagcttgat atcacattga atattatgac gctcggcgca atgaccgttg ccatcggacg 683821 tgtagtcgat gactccatcg ttgtgatcga gaacatttac cgccgcatga gactcaaaga 683881 tgagccgctc cgcggaaaag ccttggttcg tgaagcgacg aaggaaatgt ttaaaccgat 683941 catgtcatca acgattgtga caatcgcggt attcctgccg ctcgcacttg taggcggaca 684001 aatcggtgaa ttgtttattc catttgcctt aacgattgtt tttgcgcttg ccgcatccct 684061 agtgatttca atcacgcttg tgccgatgct cgcacacagc ctgttcaaaa aatcattaac 684121 cggtgcgccg attaaagcga aagaacacaa acctggcaga cttgcaaaca tctataaaaa 684181 agtattgaac tgggcgctga gccacaaatg gatcacgtct atcatcgcgg ttctgatgct 684241 ccttggaagc ttgttcctcg taccgttaat cggtgccagc tacctgccgt ccgaggaaga 684301 aaaaacgatg cagctcacat acagcccaga accgggtgaa acgaaaaaag aagccgaaaa 684361 tgaagctgaa aaagcggaaa aaatcctgct tgaccgcaag catgtcgata cggttcagta 684421 ttcattaggc tctggcagcc cgcttgccgg aggagattct aacggtgcgt tattctatat 684481 caaatatgaa agcgacacac ctgactttga taaagaaaaa gataacgttc tgaaggaaat 684541 ccaaaagcaa tctgaccgcg gagaatggaa gtcacaggac ttcagctctt caggcaataa 684601 taacgaatta acatactatg tgtatggcga ttctgaaaac gatattaaag acacggtcaa 684661 agacattgaa aaaatcatga aagatgaaaa ggatctgaaa aacgtaaatt caggcctttc 684721 cagcacatat gatgagtaca catttgtcgc tgaccaagaa aaactaagca agctcggttt 684781 aaccgcgtct caaatttctc aggccttaat gtcacaaaca tcgcaagaac cgctcaccac 684841 tgtgaaaaaa gacggcaaag agcttgatgt gaacattaag acagaaaaag acgagtataa 684901 gagtgtgaaa gatttagaga ataaaaagat cacttccgcg actggccagg aagtcaaaat 684961 cggcgatgtg gcaaaagtga aagaaggatc aacatcagat accgtgtcaa aacgtgacgg 685021 aaaagtctat gcagatgtca caggtgaggt tacctctgac aacgtcacag ccgtatcagc 685081 tgctatccag aagaaaatcg ataagcttga ccaccctgat aacgtatcga ttgacacagg 685141 cggcgtatca gcggatatcg ctgattcctt cacgaagctc ggtttagcga tgctggcagc 685201 aatagcgatc gtttaccttg tgctcgtgat taccttcggc ggagcactag cgccatttgc 685261 gattctgttc tcattgccgt tcacagtcat cggtgccctg gtcggacttt acgtatcagg 685321 tgaaacgatc agtctgaacg ccatgatcgg tatgctcatg ctgatcggta tcgttgtcac 685381 gaatgccatt gtcttaattg accgcgtgat tcataaggaa gcggaaggcc tgtctacgag 685441 agaagcgctc ctggaagccg gctctacacg actccgtccg atcctgatga cagccattgc 685501 gacaatcggc gccttgattc cattagccct cggcttcgaa ggcggaagcc aggtcatttc 685561 aaaaggactc ggcgtaacgg ttatcggcgg tttaatcagt tcaacgcttc tgacgctcct 685621 gatcgtgcca atcgtatatg aagtattggc gaagttccgc aagaaaaaac cgggaacgga 685681 agaagagtaa aaaacaaaaa gcctcagctc tgctgaggct ttcagcttgt tgaaaaaccc 685741 tcgcattcgt tgtcaggtct gcgcgtcggt gctcacgaat tctacattcg ctccgctcca 685801 atgctccccc ttcctagact acaagggttt tcaatcaagc tgaaagaatg ttaaggatga 685861 caaaagctca aaacaagaat cagttttgag cttttgtgcg ttttcacctg taagattatg 685921 tacattttgt tgcgattttt ttaactcata gtataattaa aggttgttag tgtaaaaatg 685981 gatcggatac tcttaagtag gatgatgaga taatgaaacg tgcacgcata atatacaatc 686041 cgacttcagg acgggagatc tttaaaaagc atcttgccca ggtcctgcaa aaatttgaac 686101 aagccggcta tgaaacctcc acccatgcga cgacatgcgc aggagacgct acacacgctg 686161 ccaaggaagc ggcattgcgt gagtttgacc tgatcattgc ggcaggcgga gacggaacga 686221 tcaacgaggt cgtcaacggg cttgcgcctt tagacaatcg tccgacactc ggtgtgattc 686281 ctgtcggcac aacgaacgac ttcgccagag cgctcggaat cccacgcgag gatattttaa 686341 aagcggcaga tacggtcatt aacggcgttg cccgcccgat tgatatcgga caggtcaacg 686401 gccagtattt tatcaatatc gccggcggag gccgtctgac ggagctgacg tacgacgtgc 686461 caagcaaact gaaaacaatg ctcggccagc ttgcttatta tttaaaagga atggaaatgc 686521 tgccttcact tcgtccgaca gaagtcgaga ttgaatatga cggcaagctg tttcaaggtg 686581 aaatcatgct gtttttggtc acgctgacaa actccgtcgg cgggttcgaa aagctcgcgc 686641 cggattccag cctgaatgac ggcatgtttg atttgatgat actaaagaaa gcaaaccttg 686701 ctgaatttat cagggtcgcc acgatggcgc ttcgcggaga acacatcaac gaccagcaca 686761 ttatttatac aaaagcgaac cgcgtgaaag tcaatgtatc agaaaagatg cagctgaacc 686821 tggacggcga gtacggcggc atgctgccgg gcgaattcgt gaatctgtac cggcacattc 686881 acgtcgtcat gccgaaggag aaagcggaac agttggatga ctaaaacttg gcttggtaag 686941 ccaagctcag aatgttgaca aaatcctaaa acagttttcg ttttaggatt ttgtcatctt 687001 ttcagcgtga ttgaaaacct ttgaagtcta ggaagggcga gcatcggagc acagcgaatg 687061 ttgaattcgt gagcaccgaa gcacaggcct gacaacgaat gcgaaggttt gcctacacgc 687121 tgaaacttgg cttgaatagg ccaagttttt ctttcgctta aaactagagg tgattataga 687181 tgaaaatgaa acccccagta gaaaaaaatg aatactacga tgtgacattt gaggatttga 687241 cacatgaagg agcgggcgtc gcaaaggtcc aaggcttccc gatctttgtg ccgaatgccc 687301 tacccgagga aaaagcccaa atcaaagtga cacgcgtcaa aaaagggttc gccttcggcc 687361 gcctgattga gctgaaggaa gaaagcccgc atagaacgga cgccccatgc ccgatttaca 687421 aacaatgcgg aggctgccag cttcagcaca tgacctacga aggccagctc ctgtttaaac 687481 agaaacaagt caaagacgtc ttagaacgca tcggcaagct ggacctttca aaagtcaccg 687541 tgcacccgac actcggcatg gaagacccgt ggaactacag aaacaaagca caggtgccgg 687601 taggagaacg ggaaggcgga ctcgtcgcgg gattctatca gcaaagaagc catgacatca 687661 tcgacatgag cgcctgcctg atccagcaat ccaaaaacga cgaagccgtt caagctgtca 687721 aagacatttg cgcaaactac ggtgtcaaag cctacaacga agaacgccac aaaggctggc 687781 tccgccacat catggtcaga tacggcgttg ttacgggcga aatgatgatc gtcttcatca 687841 caagaacaag cgacttcccg cacaaagcga agatcatcga agacatcaca gcgcaattcc 687901 cgcacgtcaa atccatcgtg caaaacatca acccaaacaa aacaaacgtc atttttggca 687961 acgaaacaaa cgtcatctgg ggcgaagaat acatctacga cctcatcgga gacgtcaaat 688021 tcgccatctc cgccagatcg ttttatcagg tcaacccaga gcaaacaaaa gtgctctacg 688081 acaaagcgct tgagtacgct gagcttcaag gggaagaaac cgtcatcgac gcttactgcg 688141 gcatcggaac gatttctctc ttcctggcaa agcaggcgaa aaaagtgtac ggtgtagaga 688201 ttgtgccgga agcaattgag gacgcgaagc gaaacgccga attaaacggc aacacaaacg 688261 cagagtttgc tgttggagaa gcggaaaccg tgattccaaa gtggtacgaa gaaggcatta 688321 cagctgatac gctggtcgtc gacccgccaa gaaaaggctg cgacgaagcc ctcctgcgga 688381 caattgtgga gatgaagccg aagcgggtag tgtatgtgtc ctgtaatcct ggcacgcttg 688441 cgagagattt gcgggtgctt gaggatggcg ggtacgtgac gcgcgaagtg cagcctgtgg 688501 atatgtttcc gcatacgaat catgtggagt gctgtgtgtt gataaaatta aaagaataaa 688561 tagtcaaaaa tctatgctga tggaactgtt ggttctctaa aacgataatt gatttcaatg 688621 gttccatttg catgtacttc tatttcatct actaacaaat gaagcatttc gggggtaagt 688681 gtaccttcct tcatgaattt atctaagctc tttttaaaat caattatttc tttttcaatc 688741 ttttgaaatt ctaggtcctt agatagttgg tgaagggtag tttcaaaatt tgaaatatct 688801 tcattggtga tatttatggc taattggtaa tcttctttag atataacacc attagcaaga 688861 gagataacta aattggattt atctctcttt ttatcgttta atttttcatt aatttcgatt 688921 atcttagatt cgattttttc tttgtacttt aacgcttttt cacttaattc tttaaaataa 688981 ttttccttac tgaatttcaa atatatctta tttaggttgg ttattacttt atcagttaaa 689041 tctatttcac ttacgtaatg atcactacat gcttttaaac catgtttatt ataacttcca 689101 caaacataac cttttcgatt ctttttaaaa tgcattgacc tcctgcaatc tttgcaaacc 689161 gcagtatttg taaagagatg tacttcagct tgaggtctcc ttctttttct agttattaaa 689221 atctcttgta caataagaaa gtcttctaaa ggtatgattg gttcgtggct tttttcaata 689281 attatttggt tttctaggtt aactgacctt cttcttttac tggtaacact cggtctatat 689341 tctctacatt gttgtagtgt cccagtatag tgaggatttt cgagaatttt tcttattgaa 689401 gatccgtgcc atttgtcagt agcgttcttt ttgcgggcaa gctgcgaggg actagtgacc 689461 ccttcgttat acaatcccct tgctattgca tcaaagcctt ttccagcaat atattctgaa 689521 aagattctaa tatttactat tttctctgcg tttgctgaat ttgagagaga tatgattgta 689581 gaacgaactc aagaaggtaa aatgttggcc aagcagaatc cggatttccg agaaggaaga 689641 cccaaaaagt tcacaaagca gcaaatcaat catgcattaa cattactaga aaatcattcg 689701 tataaacaag ttgaagatat gactgggata tcagtttcta cacttgtaag agctaaaaag 689761 aagaaagctg ctgaagctat aaatggataa atattgtgaa ttaattattc aatatcttga 689821 gaaattttta taaaagtaat caaaagttta atgggggaaa cgaaatggcg ctcattgatt 689881 tagaagataa aattgctgaa atagtgaatc gagaagatca ttcagatttc ttgtatgaat 689941 tactcggtgt atatgatgtt ccacgagcta caattacgcg cttgaaaaaa ggaaatcaaa 690001 accttacaaa acgggttggt gaagtacact taaagaataa ggtgtggttt aaggaggcta 690061 agaaaggaaa gctctttgac gcccttattg atatagaaca acaagttgaa tatctttcag 690121 ctaagccacg atatttatta gttactgact atgatggagt attagcgaaa gatacaaaaa 690181 cattagaggc tcttgatgtt aaatttgaag aacttcctca gtatttcgat ttcttccttg 690241 cttggaaagg tattgagaaa gtagagtttg aaaaggaaaa ccccgctgat attaaagcag 690301 ccgaacgttt tgcacggata tatgatgtac ttcgtaaaga aaacaatatt attgagacta 690361 atagagggtt agatttattt cttattcgtt tactgttttg ttttttcgca gaagatactg 690421 acatcttcaa acgaaatagt tttacgaatt taattaagac tttgactgaa gaagatggtt 690481 caaatctaaa taaattattt gctgatttat ttatcgtgtt agataaaaat gaacgagacg 690541 atgttccatc ttatttaaaa gagtttccgt atgtaaatgg ccagttgttt actgaaccac 690601 atacagagtt ggaattttct gccaaatcca gaaagttaat tattgagtgc ggtgaattat 690661 taaactgggc taaaatcaat cctgatatct ttggttcaat gattcaagct gttgcttctg 690721 aagaaagccg tagttattta ggtatgcact acacaagtgt ccccaatata atgaaggtta 690781 ttaaaccgct tttcctagat aaacttaatc agtctttttt agatgcatac gatgattata 690841 caaaacttga aaatcttcta acacgaatcg gcaaaattaa attctttgat cctgcatgtg 690901 gttcagggaa ctttttgatt attacctaca aagaattacg gcgtatggaa atcaatatta 690961 taaaacgact tcaagaactc ttgggagagt atctttatgt accttcagta actttatctc 691021 aattttacgg aatagagatt gaagattttg cacatgacgt tgcaaaatta tcactttgga 691081 ttgctgaaca tcaaatgaat gaagaattaa aaaatgaagt tcataatgca gtacgcccaa 691141 cgttaccact tcatacagca ggggatattc gttgtgcaaa tgctattagg gttgagtgga 691201 ctgaggtttg tcccgcacaa ggatctgaag aagtatatgt ttttggtaat ccaccgtatc 691261 ttggttcaaa aaaacaaaac aaagaacata aatctgatat gttatcaatt tttggaaaag 691321 tcaagaatgg taaaatgctt gattatattt ctgcttggtt ttactttggt gctaaatacg 691381 cttcaactac aaatgcaaaa gttgcctttg tatcaacaaa ttcagttact caaggggaac 691441 aggtttctat cttatggaat gagttattca agtttggaat tcaaatcaat tttgcctata 691501 aatcttttaa atgggcgaat aatgctaaaa ataatgctgc ggtaattgtt gtgattgtag 691561 gttttggccc gttagatacc aaagtaaaca agtatttatt tgttgatgaa acgaaaaagc 691621 tagtttctaa cattagtccc tatttaactg atggtgaaaa tattcttgtt tcttctagga 691681 cgaagccaat ttcagactta cccaaactgc attttgggaa catgcctaat gatggcggag 691741 gattactctt taccattacg gaatatacag acgcaatcaa taagtatcct gaattagttc 691801 cctattttaa aaagtttata ggttcagtag agtttattaa tggtggttta cggtattgtt 691861 tatggcttaa tgaagcaaaa tatgaaaaaa taaagtctaa tcctctaata caagaaagaa 691921 tctcaatttc aaaaaatcac agggaaaaat caacagataa aggaacgaat aaacttgcat 691981 taactccgtg gaagtttaga gatactcatg aaacaactaa ttattccatt gttgttccat 692041 ctgtgtcttc tgaaaataga ttttatattc caatgggatt agcaggtgca gatacaattt 692101 tgtcaaatct aatttatgta atttacgatg cagaaattta ccttctaggc attttgatgt 692161 cacggatgca tatgacttgg gtaaaagctg tagccggaag attaaaaact gactataggt 692221 actctgcagg tttatgttat aacactttcc ctattcctga attatcaaca agaaggaaga 692281 atgaaattga agaagcaatt cttgaaattc ttgatcttcg tgaagagcag ggtggtacat 692341 tagcagagct ttataaccct tcaacaatgc caattgaatt aaaagtagca catgaaaagt 692401 tggatggaat tgtagaaaga gcgtatcgtc aaaaacaatt tgaatctgat gaagaacgct 692461 tagaagtatt gcttaaattg tatcaagaaa tgacagaacg gtaggtgtaa ggtgtatgga 692521 aaatataatt gaaattaatt ataaccaaac tggtaaaagt aagaaaacaa atgaatacgg 692581 tatgcgtgaa atgcaggcaa gagcttttga aaaacgtaac tcacaatatc tcttagttaa 692641 agcaccgcca gcttctggga aatctagagc tttaatgttt atcggtttgg ataagctcat 692701 aaatcaaggt ttgaggaaag tgattgttgc tgtacctgaa cgctctatag gttcttcatt 692761 taaaaatacg gatttaaaaa gttatggttt ctttgaaaat tggaaagttg atcctagaaa 692821 taatttaact gttggcggag ataactctaa ggttaaatct tttgttcgtt ttatggaatc 692881 ggacgatcag gtgttaatat gtacgcactc tactttgcga tttgcgtttg aaaaaattga 692941 tgataaagca tttgataatt gtttacttgc aatagatgaa tttcaccatg tatcggcaga 693001 tgtcaattct cgattaggtg aattgttaag aagtattatt cataattcat cagcacatat 693061 tgtagcgatg actgggtcgt atttccgtgg agattctgta ccaattttat taccagaaga 693121 tgaggaatta tttgacaagg taacttattc ctattatgaa caacttgatg gatatgaata 693181 tctaaaggga tttggtatag gatatcactt ctatcaaggc cagtacacat cagctattaa 693241 tgaagtattg gatacaaata agaaaacaat cgttcatatt ccaaatgtaa actcagggga 693301 atcgacaaag gataagtacg atgaagttgg taagatactt gatatgattg gtgaagttga 693361 atatcaagat gatgatactg gaattattta tgttaagcga cattctgacg gtaaaacatt 693421 gaaaattgca gatttagtag atgaccaagt tggaagagaa aatgtcgttg cgtatttgcg 693481 taatattgaa gccctagacg atttagatat aattattgct cttggtatgg cgaaagaggg 693541 ctttgactgg ccgttttgtg aacatacttt gacagttggt tatcgtggct cacttacaga 693601 aatagtacaa ataattgggc gctgtacacg tgatagttac aataaaacct atgctcaatt 693661 taccaaccta atcgcaatgc ctgatgcaaa ggatgaagta gtgacttata cagtgaatac 693721 aatgcttaaa gctatttctg cctcactttt gatggagcag gtccttacac ctgactttaa 693781 atttaaacgt agaagaaatg aaagtgaaaa atcttctact acaggagaat tattcgttaa 693841 gggattgaaa gaaccatcaa cagaaaatgt caaaaagatt attgaaaatg atattaatga 693901 tttaaaagca aaaatcatgc aagattcaca agtccaaaaa acatttagtg gagaagtaga 693961 tcccaaagta ttgaacaaag tgttgattcc gaaagttatt caaaaagtat atccaaattt 694021 atcagatgag gaaattgagg aagttagaca gcacgttgtt ctagatacag ttatgaaagg 694081 tgctaagtct gaagttgtag gaagtaaaga atttataaga atggcagata agtttataaa 694141 cattgaggat ttagatatca atctgattga ttccatcaat ccgttccaaa aagcatttga 694201 ggttctatcg aaagaattga actcaccagt gctaaaactg attcaggaaa ctattgatgc 694261 aaaacgtatt aattttgatg aagatgaact agtattcata tggccaaagg tttaggaatt 694321 ttatcgttca actggtagaa gacctgattc aaaatctgaa gacccacttg aaaggcgtat 694381 gggtgaagct gtattataca tgcaagagct taggaggaaa cgtgaaaatg gcaagtaata 694441 gataccattc tattaatgaa atcatggaaa gtcagctgtt ttaccaaatc acaacaccac 694501 ctaagaaaac acaaaaagcc cagtatgatc ctgaagttga aaagtttttg gagattattg 694561 aattcgtcaa agaaaatggg cgagaacccc aaaaagtccc tactgattta actgaaagaa 694621 gtttagcaag tcgattaatt gggattcgga aagatcctga tcgtatggaa tatttgaaag 694681 agtatgatga aattggatta cttgaagtaa gatcgaagga actaacaatt cctaaaattt 694741 cttcaattga tgatattcta aaaagtggct tatctgcatt attaggtgat aatttaaata 694801 atgatataac taggtcaatt tttgatacaa gttcacttca aaaggttacg acaatgcctg 694861 aatacgttgc aaagcgtaaa aaaataaaag attttggaaa gtttgaagag ctattcaaga 694921 agtgccacaa ggaaattaca gagggtaaac gaaaaatttt aactttcaaa aatgaacaag 694981 acatacagtc aaatagtttt tatatattaa aaggagttct tctttatgtt gaagatgtgg 695041 gagaacgtaa aaaagcaaag ggaaaaacca atgctagact tcgatgtata tttgaaaatg 695101 gaacggaatc agatatgtta ctacgttcct tatcagcgga gttatataaa catggtagac 695161 gtgtgaccga caatgaagat acattgttgg ataatgttag agaagatgat gtttcgactg 695221 gctttattta cgtactaaaa tctttgagta cagatccgca aattagttcc attaagaatt 695281 tatataagat cggttttaca actggttcag tagaaaatag aatcaggaat gcagaaaatc 695341 aatcaactta tctttatgct ccagtagaaa ttgtaaccac atatcaagtg ttcaatatga 695401 atgctagcaa atttgagacg gcaatccatc atgcgctagc aaataataat ttggatgttt 695461 ctattttggg ggcaaatgga aagatgttag ttcctaaaga gtggttcgtt gtcacacttg 695521 aagatttaca agctgtaata gatgagattg tgatgatggt tcatctttat gactaaatta 695581 gtatattagg attttagtat taataataat tttatagtag actatgaaaa aatttgatgc 695641 cataacaata acttgttccg ctttggagtt tgtcacaatt gtagaattat gtgttgcgag 695701 tattaatagg aaggggttga gcgaccgcaa aaaaaatttt cggtgctgtc cgcaaaaggg 695761 agtttgggtg ttttgcgtta tatttggttg tgtgaaggtt agcggaaact caattcgtga 695821 agttaggatt gcggttatta cgactgagta gtttcgtcat actcttttag cagtttttct 695881 gtcttatgca tttctttgag catcggattc atgtagtcgt tagctgattc tagatatgct 695941 ctcgtcagag tgtctagttt atttctaact ttagagaggt cttcttcgaa ttttccatcc 696001 gatgattgaa ggataaattc ttttgcctct tcatatcttt ttaatatgtt tttcaccatt 696061 ggagttggat tcttttgatt tattgttttt attacagtga ttgttaaatt tatttgtttt 696121 attaattctt ttcttactgt caaggtgatg ctccttttaa atctctattc tatttgagag 696181 ttgctatatc tgtttaatgg tttgatagac tactcatctt tataatttag agcaattttt 696241 acaacttgtt ccgctgtgta atcttcattg ctccagaaaa ttaaatcact tggtgccgga 696301 taaggaacat ttttctctaa taaatcgaga tattcactga ctttctcatc atctaatgtt 696361 gggttcatta attcctttac aagaaagatc aactcttctt ttgtcagttt atccattgtt 696421 tgccctccaa tagattgtat ctccattgat tttacaaatg actttatttc ttctgataat 696481 gttataggtt gtttgcataa tgatagataa ttgtcttgag aaaagttagt ctcattatag 696541 agtttattaa ttgtatttat aacaatatat tcatatggaa aacctctaaa atatctttat 696601 tttagattgg tttataaaaa atagctcagc agagtagggc tgagccattt tttaattata 696661 gaccgaggta actaattaca aattctttat catcctcatc ttcaggcaaa ataccaaggt 696721 ttttatattc ccatattgcg attctttcat atccatctaa ttctgaggct aaaatatcat 696781 cataattata atctaattgg aattctccgc tacgatccaa tgttagtgta aggttagtcc 696841 aaacatcatc gttattattt ctgtgttcag ttcttaattc ttcaaaaagt tctcttagtt 696901 ctcttaacaa cgtcttgaaa atatccttgc ttacgttgta atggctaggt atatcttgtg 696961 aataaataat ttgattattt tctggtgttc tgaaatgaaa aagaaccatt gtggaatcat 697021 ctaatacttc tgcataaaga tatatctttg tccattcacc aggtatgatg tcattgagtt 697081 tttctccaat aagttgatac aaatcttgca tcttcctagt ttccattctt ctaaccccca 697141 ggctgatttt taatagagac gcttatttct tttctgctcc caattttgta ggttacatcg 697201 aaatatgatg gtctaagtga atccccagaa tagactggtt ctatttgaac tgctactttt 697261 ttaggtggtt ttttgcttag ggcttttgcc cactcctgct ccatctcata ccatttccca 697321 ccgctcctat taatctgaga attcatcggc acgatattgt caaactggcc tgagcctttg 697381 aattgggtgg cgattaaatg gccgccgtca tcgtcaggct ttcggtcctg gggctttcca 697441 gcattcgttt gtgcatattg gtttcgtttc gcttctccca gctgcaagtc tgctttgaca 697501 cttgtaattc taccatagtt gtcagtcgtg tacgtgtagc cttcttttgt tttgtagatg 697561 atattaggct tcagcacttt ctttctgctc catcttgcga aatgctcgcc gtatttgacg 697621 gttaccggcg gtacatgtgg cgctggagtt cgtcttccgc ttgatgacgt tccgtatggt 697681 ttcggcagga tgaccttggc gaatttttgc agtccttctt taagcgtgac cccgttgact 697741 gcgttgtaag gaacgcctgc cggcactaaa tcatgacggg gatgatacgg gagaatatcc 697801 gcaagtgtga gatctccgat ttgatttaac ttggttttga cgtgtttttt tgatacttca 697861 atgcctgtgt ttactttttg tttgatgtga tcaacggttt gttttgagac tgttatggct 697921 ttttgggctg ttgctgattt gcttgctgct gttttgactt tggtcgtcac tttggcggct 697981 gtgccagttt ttgagacggc tcctacgcct tttgtgccga caattgatgt gacaacagtg 698041 ccaaccgcat atgacaccca tcttgctctt gagtaggtgt caccattcac catgtctttt 698101 tgatacgatt cttcgattgc cgctgaaatg gcttcatacg ttttgatcgg gtgagccatc 698161 gctccggtaa tcgcttcaac ggttcctccc ggatctgtga ccatatccca caggcctacg 698221 accgcgtctt tcccggaatc ataaaggccg acggcaaccc ctttgaagcc tgcttcaagc 698281 tcacgcgtgt tttcaatttg ggtgaagtat ctctgttgtt cagctgtcag attttcatag 698341 ccgatcgttt ttgccatttc gtagaattca tcggcatctg cataatcgta gtttttcagt 698401 ctttctttca gtttctcaat ctcgcgttcc ttcgcttcct ctttcttaat cttcaagtaa 698461 gcctcagtcc gcttttcaat gtcgcctttt ttcttatgta tgtcactctc acggtacgcc 698521 ttggcgttgt agtggatggg tgtggcgttt ttgcctttac ccgttgcttc ttggagcttt 698581 tggaagtcgg atttgatgaa ttgttcgttt ggttcagaca gggcgtattc tgttttcagg 698641 tcttcgtcca aggcgtccaa tttttccagt gtttttttgc gtttgtcgtt ggcatcggcc 698701 agctcgtctt tgaaggtttc tgttgaaaac aggtcgagcg ggaggatgtc gtcgatatcg 698761 tttaggatgt ctttcatcgc ttttttctgt tcggacatga tggatttaga ttttttattg 698821 gcatttgcca gttcgtgctc caggaaggat tcttcgatgt atgcgtctga gaggcctttg 698881 tcttcggcgg ctccggcgat gctgttgaaa aatgcgattt tcatgtcgat gtagtcgatc 698941 cactggtcgg cgacgccgac gtggtcgtga tagaatgcct tgatgttgct ggcgcctttt 699001 cctgagaatt cactgtcact gagatcagcg actcctttta acgcttttct caagttgacc 699061 atttgcgttc ttagttcttt gtactctttt gcacggtctg tcgcttccga aagcagtgtt 699121 ttcgcttcaa atactttcat gaccatttcc cttcttttgt tcgctcaata tcaaaatttt 699181 accacgggtc gggataaggt gggggtgaga acgtgttttg gtggaaaaat gagtcatttg 699241 gcatgtgtct ttattcgtgg agggattgga ggaaacatgg tcgaaatgat attgattgct 699301 acacattttt tggaagtttg tattctatat tgttttttaa ggagcatgtt gatgacgaaa 699361 aaacggatta catttggttt attagtttta atggtatgtg tcatcctgtt tgttctgtat 699421 gttcagttac gcaataaaga tagtattcct gtccaatctt ccgccattca ccccgaagaa 699481 gaccgcatct tttttattta ctccaatcct ttcataaaag aaagcgtgct gctttcaacc 699541 tctacaggcg aacggtttaa caggcgtacg tttaaggtgg cggatgtgcc ttatattcaa 699601 acgaaatctt atgcatcaac agaccttgta ttattggcgg aacacgagcc tttttactac 699661 acgctggaga aggatgtgat caaagagcat ccgctgtcag atccatttgc gttttggtat 699721 gaggggaagg atgtcactat tgaggcctat aatgttgata cgacgggaaa tgagatccac 699781 ataaacgaca gaaaaacgaa aaaggaatat acccttacct tgcctccgct tgtcacaatg 699841 ggggccagtg atgagaactt tatttatatc attcaaagca tgtctattta cgtgattgac 699901 agaaaaacag aggaaatgat tgagaccctg agcttagcct catacgctga tcaattcgca 699961 gactcggagg aatttatcgt cgcgagctcg gatcataaat tgactgtgat tgaaaaaggg 700021 acatggaaga cgacatatat tgcgtatcct gaagatcttg aatatgcaga tactgtgtac 700081 tatgacaaag aaagcggcag tttttacgtg gcgtacgagg acaaagaggg tggagcgaac 700141 ttgctggaat atggggagga tttttctatt cacacataca gcttgaaatt cccttatatg 700201 gaggcgaagt ttaaggggaa tctattgtat atagttgccc aggaagagca taaaaagggc 700261 atcggcggat acgtgggtgt gtttgatatc cattctaagg agatgcttta tcagtttgat 700321 ttgcctgagg aacaggtgaa ggttcaggat tttgttgtgg ttgacaataa gtgaatacta 700381 tatgaaatag aatgacaaag acccttgcat aaagggttct tttttatgaa aaaaacaaat 700441 tgacaggatg aaaaaacaat ttcttccttc tatattgttt tcaaaatttg ggattgatag 700501 aatatgacat atctcataga gaaggaggga agccgttgag tcaagccata ccgtcttcgc 700561 gtgttggtgt taagattaat gaatggtata aaatgattcg ccagttcagt gttccggatg 700621 ctgagattct gaaagcggag gttgagcagg acattcagca gatggaagaa gatcaggatt 700681 tactgatcta ttattctctg atgtgttttc ggcaccagct gatgcttgat tatttggagc 700741 cgggaaaaac atacgggaat cgccctacag tgacagagct tcttgaaacg atcgagaccc 700801 ctcagaaaaa actcacaggt cttttgaaat actactcttt gtttttccgc ggcatgtatg 700861 aatttgacca aaaagaatat gtggaagcga tcggatatta tcgcgaggcg gagaaagaac 700921 tgccgtttgt gtcagatgat attgagaaag cggaattcca ttttaaagtg gcagaagcgt 700981 attatcacat gaagcaaacc catgtgtcga tgtatcatat tcttcaagcc ttggacattt 701041 atcaaaacca tcctctatac agcattagaa cgatacaaag cttgtttgtg atcgccggca 701101 actatgatga tttcaaacat tatgataaag cgctcccgca tttagaggcg gcgctggaat 701161 tggcaatgga cattcaaaat gacaggttta tcgccatttc tctattgaac attgcaaaca 701221 gctatgacag atcaggagac gatcagatgg ctgtagaaca tttccaaaaa gcggcgaaag 701281 taagcagaga gaaagtgcct gatctgcttc cgaaagtctt gtttggatta agctggacat 701341 tatgtaaagc gggccaaaca cagaaggcgt ttcagttcat agaggaagga ttagaccata 701401 tcacagcacg ttctcacaaa ttttataaag aattgtttct gttcttgcag gccgtgtaca 701461 aggagactgt tgatgaacga aaaattcatg atcttttaag ctatttcgaa aaaaagaacc 701521 tgcacgctta cattgaagca tgtgcccgga gtgctgccgc tgtttttgaa agcagctgtc 701581 actttgaaca agcagctgcg ttttatcgga aagtgctgaa agcccaagaa gatattctaa 701641 aaggagagtg tttatatgcc tattaagaaa aaagtgatga tgtgtctggc tgttactcta 701701 gttttcggaa gcatgtcgtt tccaaccctg acaaactccg gtggatttaa ggaatcgaca 701761 gatcgaaata cgacgtatat cgatcattcc ccttacaaac ttagtgatca gaagaaagcc 701821 cttagctagg gctttttctt gctttacgga agacgttcca ttttccacat cgcggcattc 701881 cttctatttc taacgcaaga cactcgaaac aaccaaacca tttgaggtat aatggataaa 701941 gtgaataaca gtatttagat tgatatatat gaaagagagt ggaacatcat gggccgtaag 702001 tggaacaata ttaaagagaa gaaggcgtct aaggacgcaa atacgagtcg gatttatgcg 702061 aagtttggcc gtgagattta tgtggcggcg aaacagggcg agcctgatcc ggaatccaac 702121 caggcgctga aggttgtgct tgaacgtgcg aagacttaca gcgtgccgaa aaacatcatt 702181 gaacgtgcga tcgagaaggc gaagggcgga gcggaagaga attacgatga gcttcgttat 702241 gagggcttcg ggccgaacgg atcaatgatt atcgttgatg cgctgacgaa taatgtaaac 702301 cgtacggcgc cggaagtgcg tgcggcgttc gggaaaaacg gcggaaacat gggtgtgagc 702361 ggatctgttg cttacatgtt tgacgcgacg gctgtaatcg gtgtggaagg caaaacggct 702421 gacgaagcgc ttgaaatcct gatggaagcg gatgttgatg tacgtgacat tttagaagag 702481 gatgacagcg cgatcgtgta tgccgagcct gatcaattcc atgcggtgca agaggcgttt 702541 aaaaacgcgg gtgtcgagga atttacagta gcggagctga caatgcttgc gcaaagtgaa 702601 gtaacgcttc cggatgatgc aaaggaacag tttgaaaaat tgattgatgc attagaagat 702661 ttggaagatg ttcagcaggt atatcataac gttgatttag gtgagtaagg agtgagcagg 702721 ctgttatggc ctgctttttt tgtcccggaa attgttttag ctgtatgtag gcggccgcct 702781 atacgatcta taagatattc tcatactctg gactgtaacc tatgtgaagg agagagtaaa 702841 tatgactgat acaagacata tgtatggcgg acctggtttt ggtcattatc agggctttgg 702901 tattggccac ccgggctatg gcatgcaaag cacaggctat ccgggctatg gcatgtatgg 702961 aggccacccg ggctatggca tgcaaggcta cccagatcac ggcatacatg gaggagtcgg 703021 cggctatccg ggatatggtg ggtacggcgg ttacccaagc ggcggctatg gaggctctcc 703081 gggaactgga agctatccga gcatgcacca tgaaaatgat ggccatcacc actattatca 703141 ccatcatcat gatggaaaag ataatcttca tcaccatcat caccatgttg gaaaggataa 703201 tcatcaccac catcatgatg gtcattatgg ccaccatcat caccatatgg gccactgggg 703261 aaaagacggt tataaataaa gaagatgatg ataaaaagag gacactcttg cagatcaaga 703321 gtgttttttt agcttttttc ttgactgttc agtctggaaa atggtaacat ttgtttcagg 703381 aggtgatcat tttttgggga ggaataaaga atttgatacg gcgcttgttc ttcacagggc 703441 gatagaggtt tttggagagt atggctacga aggaacgtct cttcaggatc tgctctctca 703501 tttaggcatt gcgcgccaaa gtttgtatga tacgtatgga acgaagcgtg atttgttttt 703561 gtccgctgtg aaatcgtatc ttgaagggaa aaacgctgcc gttatggaaa ggcttgaagc 703621 gccaggatct gtaaaggaag ccattcgtga tatttttcag gagggtgtca atgccctgag 703681 ggatccggaa cgggcgaagg cgtgctacat tattaacagc gcgattgaac agatcccgca 703741 tgaccctgag cttgcccggt attttgaaag acaatccaag cagcttgagg acgcttttta 703801 tcacgggctt ttaagagcga aggatcaagg agaattgaat ggcgaagata ctgatatatc 703861 tgcgcttgct cggtacctga atcagagcag gctgtcactg acatttattg caaaagtgac 703921 ggcagatatg gatcggcttc aggaccatgt tgacgtgagt ttatcagtgc ttgattaaca 703981 tgtggtaaag gattctttgc ccatgtatgt actttttgga ctgaatagtc tagaaataaa 704041 aatgaggtga tgatgaatgt tgatgaatga gtttgaaaaa gcatgtgaaa cattgagaaa 704101 gtttatggct tatatgcttg agaaggacat gaagagctgg acggagcttt gggatgagaa 704161 tgctgtattt gagtttcctt atgcgccgga gggatcacca aaaagaatag aaggaaaagc 704221 ggccatttac gattatatta aagattatcc taagcagatt catctttctt catttaccgc 704281 tccgacagtg taccgttcag cagactcgaa tacggtgatt gcggagtttc aatgtgacgg 704341 ccatgtgatt gagactggac tgccttatcg ccaaagctat atcagtgtca tcgaaacgag 704401 agacggccgc attgtgcgtt atagggatta ttggaatccg cttgttgtaa aagaggcctt 704461 tggaggatca tttttgcaaa cagaggagag tgggaaatga tgaaacagaa tccgatttta 704521 atcacgggcg ggaccggcac agtcggcagc cgaatcgcca gccgtttaat aaagctggga 704581 tacagagtgc gtattgcaag ccggaaaaag ggcgcgcttg ctgatgctga gtatgtgtat 704641 tttaattgga agtacgcctc cagttttacg cctgctctgg aacaggtaaa acagatctat 704701 cttgttgctc cggtcggtgt atttgatccg gctccctatg tgcttccctt tttaaaggaa 704761 gcaaagcgtc tcggcgcaaa gcgggtagtg atgcaaagtg cgtctgttgt ctccgagaac 704821 ggtcccgtgt ttggcgcgct tcaccaggca gtgcgcgagt ttccagaatg gacggtgctg 704881 cggccctcat actttatgca aaatttcatc aatgtccagc accgcatgtc tattcaaacg 704941 gaggggcgca tcacaacggc ttcgggtgaa ggaaaacttg ggtttattga cgctgatgac 705001 atcgcagaaa cagccgtcag ggctttgatt gatgatgttc ctcatcaaac acatcatatt 705061 ctgacaggtc ccgaggcgct gagctatgcc gaagcggcgg agatcattgg agctgcggcg 705121 ggacgccggg tggagcatgt cagcatttct cgttccgagc tgcagcataa aatggaggca 705181 ggaggtttgc ccgcggatta tgcccatttt atggcgaagc ttgatgaggc aattagccat 705241 ggtgcggaac atcgggtaac ggatacagtg aagcgtgtga cgggaaaaga acctcgttcg 705301 ctgtcagagt ttgcggctgc tcatgctgca tattggacct cattttggac tgaatagtct 705361 agaaagacct tcggcgcttc cgaaggtctt cttattgaaa aagctaagtc gtgttttagt 705421 cataatcatg cctcctgcct catacctatt aaggtcattg tttttgagaa aggaggagcc 705481 ggaatgaagg atatgcagcc gtttacgcct gtcaaatcat atacgccctt tcacagccgt 705541 tttgatccct gtccgcccat agggaagaaa tattacagaa cgccccctaa cctttatatg 705601 acctttcagc ctgagcacat ggagcagttt tcgccgatgg aggctttgag gaaaggcacc 705661 ctttggaagg atctctatga tttttatgaa aacccttatc gagggggaga cgcacatggc 705721 aaaaaaggtt gacgccgaat attatcgtca gctagagcaa atacaggctg ctgattttgt 705781 gcttgttgag ctgagtcttt atttaaatac acatcctcat gatgaagatg cgttgaagca 705841 attcaatcaa tattccggct attcaaggca cttaaaaaga cagttcgaat cctcttacgg 705901 accgcttctg cagttcggca acagccccgc gggcaaggat tgggattggg gaaaagggcc 705961 atggccgtgg caagtataag gaggaatgcc tgaatgtggg tgtatgaaaa gaagctgcaa 706021 taccctgtca aggtcagtac gtgcaacccg acgctggcga agtatttgat tgagcagtat 706081 ggcggagcgg acggcgagct ggccgcggct ctccggtatt tgaaccagcg ttatacgatt 706141 cctgataagg tcatcggcct tttaacagat atcggcacgg aggagtttgc ccatttggaa 706201 atgattgcga ccatggtcta taagttaacg aaagacgcca caccggagca gctgcgtgaa 706261 gctgggcttg gcgatcatta cgtcaatcac gacagcgcgc ttttttatca taatgcggcg 706321 ggcgtgccgt ttaccgcgag ctatatccaa gcgaagggcg atccgattgc cgatttatac 706381 gaagatattg ccgcagaaga aaaggcgcgg gcgacgtatc aatggctgat tgatatttcg 706441 gatgatcctg atttaaacga ttccctgcgt tttttgcgtg agcgtgaaat cgtacactct 706501 atgcgcttca gagaagcggt tgaaatttta aaagaagaac gggataaaaa gaagattttc 706561 taataggcag attggcctct ctttcataca cccttttaca tacagagaaa atggtctgtt 706621 tttgcagttt ggtctgcatt ataatcaagg tgtgtgtgca agcttacttt ttgattggga 706681 ggcctttatg acagctttta agattgagaa cgaaacgatt gcagatggat tttacgcgtg 706741 tccggccgtc tatgaggatg cagaatcgat taccgggttg ctcgtccgaa cagctgaatg 706801 gctccgggat cggggttcta accaatggag cggacttctc aaagggcaag atatacatga 706861 tatcacgggg tcaattgaaa agggacatgt gtttgtgttt aaaaaagatg aagagcttgc 706921 ggctgtcgtg atgctgctgc ctgcaccgag cgagtgggac cggacgcttt ggggagacga 706981 tgggcatgag gagtccattt atttacaccg cctcgcagta agccgccggt ttgcgggaca 707041 ggggcttgga gcccgcgtcc ttcagtgggc ggagacgggc atacactttc cggaaaaaac 707101 gcggatccgg cttgactgtg tcgctgatag tgacgccctg cattcctttt atcggcgtat 707161 gggatatgaa ttcatgggtg ctgatgcgtc cggatatcat ttgtttgaga aagagattac 707221 ggcagaataa gcgtcctttg cagggggctt ttttgtcttt ttctaaaagg gaggcaggcg 707281 atgtgtggtc aatattattt gtgacaggga ttgtgacggc ttgtctgttt gctggcgtat 707341 ccgtattgat gcggatgaga tttcctgaca aaagtcggcc ggaatggatg ttggccgggc 707401 tgatcgtcct tggtgtgttt gcgatctggt acagcctcgt gtatgtacgc ggctgggaag 707461 gggctgcgct cggaatgctt ggattcaatg tcattttcgg agccattgcc ggatatttga 707521 tcgataaggc catccggcgt tacaggaaaa gataaggctg ctgccgtctc tcaacaggtc 707581 gaaattttca cagaccggca ggaattttct ttcgaaagga gaaatacata ttactttaaa 707641 atgaaagcgt tttccaaagc aggaaggtga tgttgatgat acacagtgtg gcaaatgggc 707701 tgaatcattt ttgtacgtgg gtgatgagac tggcctattt gaatgtgctt tggattttgt 707761 tttctcttgc aggcctggtt gtatttgggc tgatgcccgc tactgccgcg atgtttacag 707821 tggcgagaga atgggcgaag gggaatacag atgccccggt gttttctgtc ttttttcgga 707881 cgtttaaaaa ggaatggcgg gcatcacaga tcctcgggct tatcgttgtg acggctgccc 707941 tgtttctgtt tgcggatatg cggatagcgg ctcagatgga ccagcctgtg ctcgtcaatg 708001 tattcgtgag cattagtttg attttcgcgt ttgttgtgct gtatgtgttc ccggtatttt 708061 ctcattttga cgtaaaaatc agagaggtgc tgagcatcag ctttttcatt gccttcagtc 708121 gtccggcggt gacgcttttg atggcagcgg gcgctgtcgg tgtgctttgt ctcgttctgt 708181 ttcatgtcac gtttctattg tttttcagcg ggagtttact cagcctgatc ttaacgaagc 708241 tgtcctttaa agcgtttcgg tcaatggatc agcggcagga gaaagaaaag gcggcatgaa 708301 gaaaagagtt gctggctggt acaggcggat gaagattaag gataagctgt ttgtgtttct 708361 atcgttgatt atggccgtat cctttctgtt tgtatacagc ggggtccagt atgcctttca 708421 tgtgtatgat gagcagattt accgcaagtc ctcggaggtg cttcggatgt cttctgaaag 708481 gatcgaagac gagctgaaga agatagagga tgtgtcatat gaaatcatta cagacgaaca 708541 gattcagcgc atcctgagca tgcaaaatcg ggatgatacg tatgatcaat atcaaatgaa 708601 gcaggagctg tgggatcagc ttgcgggata tgccagcgat gaaaagtaca tcgattccat 708661 tcatgtgatt gatgcccgcg gctcagagta ttcagccgga agcagttctt cagatctttt 708721 gcagcaggag caggaagagg tatttaagcg agcgaaagcg aaaagtggaa gaaatctttg 708781 gatgacgctc ggcgggtcag accccgtcct gatttcagca cggcagatca ggtcctatca 708841 ccagctgagt ctgaacggct tgggcatggt actgatccag gtcaatgtaa aacagatgat 708901 tcgtgatgtg ccgaaggatt ggggcgattc agtcggagac attatgattg ctgaccaagg 708961 cggtaatttg gtgtatacgg cacatgcatc agcgcatgtt cctgaggcag caaaagagac 709021 gttgaagcac cccggttatg acttgataaa aaagaatggc aaacgttact ttatttctta 709081 tcttcaatca tcctaccaaa attggagcta ctataacgtt atcccctttg atcagatgtt 709141 cgcaaaaatt tcctttatga aaacagtgat cggcacatgc tttcttctct ttttctgtgt 709201 ggttttgctt ttcggaagga aaatcgccaa cagcatcacg gagccgattg aacagcttgt 709261 gaccgcgatg aaatcggtac agcacagcgg cattgaagca ggtgtgtcgc tttctctgcc 709321 ggaacataca caggatgagg ccggcatgct gaaccgccat tttactgtca tgatgaaacg 709381 gattaatgag ctgatggaag aaaatgtgga aaaacagctc atcattaaag aaaccgaatt 709441 gaaagcactg caagcccaga tcaatccgca ttttttatat aacacgctcg agtccatcaa 709501 ttggctggcc aaggcgaatc agcaaaagca aatctcaaaa atggtggaat cgctcggttt 709561 tcttctgcga aacagcatac atatgaagaa ggatatcgtg accattcagg aggaggcgga 709621 cattgtacgt cactatatga ccattcagcg atttcgattt gaagagcgcc tgaaattcac 709681 gttggatatt gacgatgagg tgaagcattg cctcattccg aaactgacgc tccagccgct 709741 tgcggaaaat gcgattcaat acgcgcttga accctttaca aggccatgcg ccatccggat 709801 tcaggcgaaa aaggcgaagg gctgtgtctg tattacggtc gaagataacg gccctggcat 709861 ggatggacgg attcttgaat caacgggtgg aagaggaatc ggactttgga atattcgcga 709921 gcgcatcagc ctgacattcg gagagccata cggattgcgg attcatagtg agcatgaaaa 709981 ggggacgagg attgtgatca caataccgtg ccgaaatgag gtggtgtgat gtataaaata 710041 ctgctggctg atgatgagag gattatcctt gatggaatgg cgggaatcat tgagtgggag 710101 tcgcttggcg cctcattgat cggaaaagcg cagaacggac atgaagcata tgaaaagatt 710161 gtacataagc agccgcatat cgtcatcaca gacgtcaaaa tgcccggcat ggacgggctt 710221 gagctgatca aaaaggtgtc agccgtcagc ccgtcggtgc aatttatcgt cctgtccggg 710281 tttggagagt ttgagtacgc aaaggaagcc atgaaatatg gggtgaagca ttatttgctg 710341 aaaccctgca atgaacagca gattatcagc tcgctggagg aaatcattgc tgagctgaag 710401 cggcaagatg tgcacaaaaa gaaaacagcc catctgaaac acgagctgga ccatatccgt 710461 tcctttgcag ccgatcaata cttggaaggc ttgatcgccg gtgtggccca gctttctccg 710521 ccgccttcac ttgccggaaa aaagatccgc ctcttgatct taaaagggga acaatctatt 710581 gatgctgcag ccagagaggc actcggatcg gcactgacag cggtttgcag cagcggtgaa 710641 tggaccgtgc tcgccgtaga ggagaacgcc gctgaaaagg tggcggaggt ttttgcggac 710701 cgcaagatgg ccatcagtca ggcgggagaa ctccggcacg cggggcagct gtttcgtgac 710761 acagctgaag cgtctggtga cctgcatggg agcgcagtga tttcaaaaat gatcaggctt 710821 attgccgacg agctcggaaa tccgaatctg tccttaaaat gggcggcgaa ggatatgctg 710881 tttatgaatc ctgattatct cgggaagtta tttaagcagg aaacaggcga gaaattttcc 710941 caatatgtta cacgggtgcg tcttgagcat gcgatgaagc agatgaaaat aaggagggac 711001 gtgagcgttt cagaaattgc tgaagaaatc gggtttggcg ataatccgaa gtatttcagt 711061 cttgttttta aaaaatatac cggtctgaca ccgtcagaat tcagaagaaa acagggaggc 711121 gcttccgcag gatagccatc tctgtttttt tgactttcgc cactgttttt tgagtgtttc 711181 gccctatccg aacgctttaa aataaaatgt aagcacttac attaaagggg ggattggttt 711241 gaagaagatt tgttacgtgc tgttatccct tgtctgcgtc tttttgttca gcggatgttc 711301 agcgggtgaa gaggcctcgg gaaaaaaaga agatgttaca ctcagaatcg cgtggtgggg 711361 cgggcagcca aggcatgatt atacaactaa ggtaattgaa ctatacgaga aaaagaatcc 711421 gcacgtccat attgaagcgg aatttgcgaa ctgggatgac tactggaaaa agcttgcgcc 711481 catgtctgcc gccggccagc ttcctgatgt cattcaaatg gataccgctt acttagccca 711541 atacggaaag aagaaccagc tggaagattt aacgccgtat acaaaggatg gaacgattga 711601 cgtcagttca atcgacgaga atatgctgtc gggcggaaaa atcgacaata agctttatgg 711661 atttacgcta ggtgtcaacg tgctgtctgt gattgccaat gaagatttgc tgaaaaaagc 711721 cggtgtgtct atcaatcagg aaaactggac gtgggaggat tacgagaagc tggcgtatga 711781 tcttcaggaa aaagccggtg tctacggttc caacggaatg catccgcctg atattttctt 711841 cccttattat ttgcgcacaa agggtgagcg cttttataaa gaagacggca ctggcctcgc 711901 gtatcaagat gatcagctgt ttgtcgatta ctttgaacgg cagctgaggc tagtgaaagc 711961 gaaaacgtcc ccaacacctg atgaaagcgc acagattaaa gggatggaag acgattttat 712021 cgtcaaaggc aaatcagcga ttacatggaa ctactccaat caatatttgg gctttgcccg 712081 gctgacagac tcgccgctgt ctctctatct gccgccggag caaatgcagg aaaaggcgct 712141 gacactgaag cccagtatgc tgttttccat tccgaaaagc tctgagcata aaaaagaggc 712201 agcgaaattt attaatttct tcgtgaataa tgaggaagcg aaccagctga ttaaaggcga 712261 gcgaggcgtt ccagtctccg acaaggtggc ggatgcgatt aaaccgaagc tgaatgagga 712321 agaaaccaac atcgtggagt atgtagaaac cgcgtcaaaa aacatcagca aagccgatcc 712381 gccagagcct gtgggaagcg cggaggtcat caagctgctg aaagatacgt cagatcagat 712441 tctgtatcag aaggtatcgc cggaaaaagc cgccaaaacg ttccggaaaa aggccaatga 712501 gatattagag aggaataatt gacgggaaat ggggctgacg caatgaaaaa aagccggagt 712561 ataagaaaag acaatctggc gggatatgct tttatttctc cgtttatcat cgggttccta 712621 tgctttacgg tgattccgat gggggcgtcc ctgtttctgt ccttcacgag ctatgacttg 712681 tttacggcgc cgaaatggat cgggctcgac aactttaagg aaatgtttac gggtgacgaa 712741 aagtattggc agtctctgaa ggtgacgttt acgtatgtgc ttgccggggt tccgctccgc 712801 ctcggcttcg cgctttttat cgctgtcatt ttaaacaatg cagcaaaagg aacggccatt 712861 tacagaacgc tcttttatct gccttcgatc atcggcggga gcgtcgccgt ggcgattatg 712921 tggcgcaata tttttggcaa tgacggggtc atcaatgcgc tgctgttttt tgtcgggatt 712981 gatcaaaaaa ttctttggta ccagaatccg acaagtgcgc tgtggacatt gattctgctg 713041 tccgtctggc agttcgggtc gtcaatgctg atttttttgg ccgggctgaa aaacattccg 713101 tcttcgtatt tggaagcggc aagtgtggat ggggcaaatc gggtgcagcg tttcttcaag 713161 atcacgcttc cgatccttac accgattatt ttctttaacc tagtgatgca gacgatttct 713221 gcttttatga catttacacc tgcctatatc atttcgaagg gcgagggcgg gccgcttgac 713281 gggacacttc tctattcgct ctatttgttc cagcgtgcgt ttaactattt tcaaatgggc 713341 tacgcatcgg cgatggcgtg ggtcatgctt gtcattgtcg ggctgattac gctcatattg 713401 tttaaaacat cgtcatattg ggttcattac gagtcaaagg aggaatgacg gatggagccg 713461 gtcaaccagc ctgtcagaga agccccggtt tttgagagaa aaaaagccgg gcgcgtcagt 713521 cccaaacgca tactgttcca tgtttttacg gcaacgctgg cggtgttgct gctgtacccg 713581 gttatttggc tgtttgtcag ctcgtttaaa gaaagcgcca gtatttttac aacctcacat 713641 tctctcattc cagacccttt tattctcagt aactatgctg aagggtggaa gggcattgcg 713701 ggacagccgt ttctgacgtt tattaaaaac tcggcgatta ttgtcgggct gtcaacaatc 713761 ggtgccgtca tgtcatcggc tgtcattgcg tacggatttg cgcgtatacc gtttaaggga 713821 aaaaaatttt ggtttgcgtg catgatgggg acgttaatgc tgcctcatga agtgttgatg 713881 attccgcagt atattatgtt tgcgaaatta gactggctga attcctttaa accaattgtc 713941 gttccgcaat ttttcgggca tgcgtttttt atctttctga tgatccagtt tatccggacg 714001 attcccgagg agctggatga agccgcgcga atcgacggat gcggacgctt tgcctgcttt 714061 tggcggatca ttctcccgct gattgccccc gcgcttgcga cgtctgcgat tttctccttc 714121 tattggaagt gggaggagct gattcagccg ctcttgtatt tgaataagcc ggagctttac 714181 cctgtttcac ttgcgctgaa gctttttctc gatacagagt cggcttcgaa ctggggcgcg 714241 atgtttgcca tgtcagccgt ctcgttattg cctgtgattc ttgttttctt tttgtttcag 714301 aaatatatcg ttcagggcat cagtacgacc ggattaaaat aaaaaggagt gttgcagatg 714361 gcacagctta tctttgatga agaaaaggtg acgtcggtta ttgaccggat cgtgaaacgg 714421 acatttcaga tggattttgc gtgggattgg ccgggcggcg ttgcgtttta cggtgtggcg 714481 gaggcctatg aagcgacgga aaacgaggaa tatatcaatc tgttaaaaac gtgggtggat 714541 gaacagctgg aggatgggct gccgccgctt tcgatcaacg gagtttccat tgggcatacg 714601 cttttgttcc tccacaaggt gacaggtgat gacgtgtatt tggaaacagc ggccgagatg 714661 gcggaatatg tgctgcataa ggcgccgcgc tttggcgagg gtatccttca gcatacggtg 714721 aatgcggcag aatacgtatt ccctgaacag gcatgggcgg atacgctgat gatggctggg 714781 ctgtttatgc tgagaatcgg gcgggtcatg gagcgtgagg attattttga agacggcctg 714841 cgccagtttc acggacatga ggatgtgctt caggaccctg tcacgaattt gtactaccac 714901 gcctgggaca acaaagcgca aaatcatctg tcggggattt attggggcag ggcgaacggc 714961 tgggcggcac tcacgatggc aaaggcgctc ccgcttattg aggtgacaca tccttccttt 715021 atgatcatcg acggatcgct cagagaccag ctgagcgcgc ttgtccggct tcaggatgaa 715081 tcagggctgt ggcatacaat tttggatgat ccggattctt atctggaggt ttcggcatca 715141 gcgggtattg cttctgctct gatgtcgagc ggaaagctgt atacaaaata tgtgcagaaa 715201 tcgcttgccg ccattttgga tgcagtggaa gaggacggac gggtcagcag ggtatcggcc 715261 gggacagccg tcatgaaaaa tgccgaagga tacaaacagg tgccttacaa acgaatacaa 715321 ggatgggggc agggacttgc gctgacgttt cttgctgatg ttttgaaaac gaaaaaacgc 715381 ttgtatcagt aaagatagcg gcggggggag agggatgaaa aaacagcctc aacagaagga 715441 acgggtttct cgctggaagg gaacgtattt caaaagaaac tttgtcttca ttttgctgat 715501 tgcctgtatt cccggattgc tgactggcgg cgcaatctac tttctttcga tcgacaaggt 715561 ggagaaagag ctgcagagat cgcatgaaac acaggtggcg cgtgaggtca gccgaatgga 715621 tgagaagctg ggagtgcttg aactggcact cacccagatg gcctacgatt cttcactgat 715681 gaacggattg gccgagaggg atttggagaa agactttacg ttctcctatc aattaacgaa 715741 aaagctgttt cttttgcggg atcagcagcc gctgatcgag caggcttcca tctttctgaa 715801 cagcccccgg ccacttgtgc tgagccctga atacagcgct ttgacagaac aggaggcgct 715861 tcgcaagtat cgctcgctgc ttgcctcaga ccacagcatt tattggaaac ggtcgggaaa 715921 ccaagcgatg ctgatccagc tcattccggg cgcggcggag aaaccgttcg gcgcgatcat 715981 gctggcggtt gatccgaaag aaatggaatc aatcctgcaa agcttgtccc cctatcctga 716041 tggcagtgcg ttgcttttag atcaaaatcg agaggtgctg tttcatgagg gggaaaaaga 716101 ttttgaaaag actttacttc atgagataaa aaaacagcct gctgagaacg gccattttca 716161 gatggaatgg aaaggcaagg tgtattctgt ctcctttgga gaaatgaacc ggatgcatca 716221 gcaatggacc tttgtgtcag cggcgcctct ttcagctatt acagcgccga tggtgttttt 716281 atcaaaagtg atcatcgtga tgctggtcat ttgcatcggt ttggcggtgt gcatgacatg 716341 gtatgcatca aaaaaaatct atcgtcccat ccagcatttg cttggcttgt ttaccggagg 716401 agagaagaaa acatggcagg cgtccgggca ggatgaattc aaatggattg aaaagagatg 716461 gcaggatcta tcccttgaaa gccggaagct ccaacagcag ctcctgcggc agacgcccca 716521 tatgaaaaag agttttttgc agcatctctt acagagcgat ttttactatg acaacgagga 716581 aagcctcaga tttcggatgg aggaggctgg ctggaacatc ggcggaaacg tgtttcatgt 716641 gcttgatcta caggtgacag ggctccgctg tgaaaaaagc atcttccgtg aaggtgatga 716701 acagcttgcc gtgtttacac tgactaatat cgctgaggaa ttggcggcta aacgcgtttt 716761 tcagctctcc atacttgata tcggccggct ttctgtcacc gttcttgtga tgaaaacaaa 716821 cagctctgat ctgaaggcgt atataacgga gctggcacgc caatttggag atgtaaccgg 716881 actatgcctg acctcgacat tgagcagcaa gacggagcgt gtcacggaaa ttccttcttt 716941 atttcaggat gtgaaatgcg gcaaatcccg caggaagttt gctaaccggg atcaggtcat 717001 tgatttgcag gccgacttcc ctcgggatga gcagttcgct ccttattacc cttttgagct 717061 ggaaaaacaa attgttcaga ccatccggct ggaaagaaaa caggaagcca aggaactgat 717121 agatggatgt atgaaggaac tgtcggaaaa agcggccata gacaggcatg tgcattccgc 717181 cctgattcag ctgttttccc gcattcagga ggatattttg cattccgggc tcaatcccag 717241 cgaactgttt cagcaccgga atccgtttct tgatatttca gaattgcgcg aacctaacga 717301 agcggcggcc tggctgatgg atgtagtggt gacgccttac ctttccaagc ttgagggcag 717361 aaaaaacaga cagcaaaagc agctggcaga acgtgtgatt gcgatgattc acgaacagta 717421 tatggcggac atttcattgg aaagctgtgc cgatgcgctt ggcatgaatt cctatacgtt 717481 aagcaaggca tttaagcaag tgaccggcat taattttatc gattatgtga cccagatcag 717541 aatcgaaaag gcgaaagaac tgctggtcaa tacgaataaa aaaattcatg atgtgtctga 717601 agaagtcggc tatcgccaca attatttcaa tcggattttt aaaaaacagg tcggcatgcc 717661 gccgggtgtc ttcaggcaaa tgtatcagga aacgccgtga aaggagagaa catgtgatga 717721 agaaaccgat tcaagtattt ttagcggggg attccactgt gagtgactgc ccgcctcatg 717781 aagcgccgat ggcggggtgg gggcaggtat tcgggcaatt gttttctgaa ggtgtgctgg 717841 tccgcaatca tgccaaagga ggagcgagca ccaattcttt tgtggaggaa ggaaggcttc 717901 aagcaattgc cgagcacatc acacaaggcg attatttgtt gattcaattc ggccacaatg 717961 accaaaaacc gcgggggacg aagccgtact ccacatttca gcagtttctt accttgtttg 718021 cagatacggc acgcgaaaag ggcgcgcatc ctgtgttcgt cacatcggtg cagcgccgcc 718081 gctttgatga aaacggacgg atcgagcata cgctcggtga gtatcccgat gcgatgaaag 718141 cactggcgaa ggagctcgat gtacctgtga ttgatctgct tgcgaaaaca aaggtgctgt 718201 atgaagcata cgggccggag gagtcgaagc gattgttcgt ttggtttcag ccgaatgaac 718261 atccgaatta cccggacggc attgaggaca atacgcattt ttcggaaaaa ggtgcaatgg 718321 aggttgcgaa gcttgtggca gaaggcattg aagagctcgg acttccgctt aaggaccacc 718381 ttgtgagccg ggagggaaaa gaacatgtat aaggaaggcg cttgcttgta ccgcaatccg 718441 ctccggtcta aaagcgatgt gaaggattgg cggatggagg gaggcggaca gatctcattt 718501 gacgatcaca gcttgcacct gtcacatgtc caggatgaag cgcactttgt cttttggtgt 718561 ccggaaacct ttccagacgg catcattgtg acatgggact tctctccgat cgagcagcct 718621 ggactgtgta tgctgttttt tgccgctgcg ggtattcgcg gcgaggattt gtttgaccca 718681 agtctcagga aaagaacagg aacataccct gagtatcatt caggagatat caatgccctc 718741 cacctgtcgt atttccgcag aaaatacgcg gaggaaagag cgttccgcac ctgcaattta 718801 agaaaaagcc gcggtttcca tctcgccgca atgggggccg atccgctgcc ttctccagac 718861 gacgctgatt ctccgtatcg tatgaagctg atcaaagaca aaggctatgt gcacttttca 718921 atcaatggtc tgcccattct tgagtggatg gacgacggca gcacatatgg gcctgtgtta 718981 acaaaaggaa aaatcgggtt ccggcagatg gcccccatga aagccgttta cagggatttt 719041 gccgtgcatc aagcggtgag aagatgaaga cgactgtaac ggatgcgctt tatgcaggct 719101 gcgaagcggt ggtgaaaata gcatggctca acgggctgtg gctgttgttt acacttttgg 719161 gcggcgttct tttcggatgg gcgccgagca cagctgcgat gtgtgccgtt ataaggaaat 719221 ggctgatggg gcaaaaggat gtcccgatat tttcgttatt tctcgatacc tataaaaaag 719281 agtttctcaa ggttaatgcg atcggattgg cgttttcggc tcttttgctc atattgtctg 719341 ccaactatca ttatttttct gccagtacga attggctgtc ctttgccgta acaagctgca 719401 cgctgcttgc agggcttttg tatatcatcg cgctgatgta tgtgtttccc ctttatgtgc 719461 attaccagct cccgcttcgc aaatatattc cgcaggcact gctgtttggc gccatgagac 719521 cgctgacaac tggctgtatg ctgatcgggt gcggatttgt cctttatttg ctgtatacgc 719581 ttcctggcct gatcccattt tacggcccgt gtttatttgg gcttgtgttg atgttttttg 719641 ctcttagggg atttcaaaag acggaggccc agcaccatca agccgggtaa caaaaaaatg 719701 acaaataagc aaaaaagtgc agtgtccgaa ataggcagat gcaaaaaagt gaaattgaag 719761 acagctcaca aagcgcataa aatccaattt aagtaagcgc ttacagataa atgagaagga 719821 gctgtctgat gattagacga aggaaacgca tgtttaccgc tgttacgttg ctggtcttgt 719881 tggtgatggg aacctctgta tgtcctgtga aagctgaagg ggcagcgcgg cagatggaag 719941 cgctgaaccg ggggcttgta gcggtcaaga cggacggggg catttttgtc agctggcggt 720001 ttcttggaac cgaaaacgca tctgttttgt tcaatgtgta cagagacggg caaaaactga 720061 atgctgcgcc tgtcaaaaca acgaactatg tggataaaaa cggttcggcg ggctcaacgt 720121 atacggttcg ggctgttgta aacggtaccg aacagccggc ttctgaaaaa gcctccgtat 720181 gggcgcagcc gtatcattcc gtcccgctgg ataaaccggc tggcggcacg acgccaaagg 720241 gtgaatctta cacgtacagc gctaatgacg caagtgttgg cgatgtggat ggtgacgggc 720301 aatacgagct gatcctgaaa tgggacccgt ccaactcaaa agacaattca caggatggct 720361 atacgggtga cgtgctgatt gacgcgtata aactggacgg cacaaagtta tggcggatca 720421 atctcggcaa aaacatcaga gcgggcgcgc actacaccca gtttatggtg tatgaccttg 720481 atggtgacgg aaaagcagaa gtggcaatga aaacggcaga cgggacaaaa gacggcacgg 720541 gcaaagtaat tggaaatgcc aatgcagatt acagaaatga acaggggcgt gtgctttcag 720601 gccctgaata tctcactgtg tttcaaggtt caaccgggaa agagcttgtc accgcaaatt 720661 ttgaaccggc gcgcggcaat gtgtcggatt ggggagacag ctacggcaac cgtgttgacc 720721 gttttctcgc cggcattgcc taccttgatg gacagcggcc gagcctgatc atgaccagag 720781 ggtattacgc taaaaccatg ctagttgcct ataacttcag ggacggaaag ctgtcaaagc 720841 tttggacgct ggactcctca aagtcaggaa atgaagcgtt tgccggacag gggaatcaca 720901 acctgagcat cgcggacgtt gacggggatg gaaaagatga gattattttc ggctcaatgg 720961 ctgttgatca tgacgggaaa ggcatgtact cgaccggctt aggccatggg gatgccctcc 721021 atacaggaga tcttgatccg ggccggccgg ggcttgaggt gtttcaagtt catgaggaca 721081 aaaatgcaaa atacggctta tctttccggg atgctgcaac tggaaaaatc ctttggggcg 721141 tttatgccgg caaggatgta ggccggggaa tggctgctga tattgacccg cgttatccgg 721201 gacaggaggt gtgggcaaac ggttctctct actcagcgaa aggggtcaaa atcggaagcg 721261 gggttccgtc ctcgaccaac ttcggcatct ggtgggacgg cgatctgctc cgggaacagc 721321 tggacagcaa ccgaattgat aagtgggatt atcaaaacgg cgtatcgaaa aatatgctga 721381 ctgcatcagg cgcagcggct aacaacggca caaaagcaac accaacgctt caggctgatc 721441 tgctcggtga ctggcgcgag gaagtggtgt ggagaacgga ggacagcagt gctctgcgca 721501 tttacacgac gaccattccg actgagcaca ggctgtatac gctgatgcac gatccggtgt 721561 accggcttgg catcgcctgg caaaatatcg cctataacca gccgccgcac acaagcttct 721621 ttttaggaga cggcatggcg gaacagccaa aaccaaatat gtatacgcct taactgaaag 721681 ggggaaggaa cgggctgcgc gcagcccgtt cccatcaaat gaaaccaaaa aagaggcaaa 721741 tggaatacct gaccagaggt ttgattgcgg tacagacaga acagggcgtg tttgtcagct 721801 ggcgttttct cggcacggat catgagacga cggcttttca cctttatcgg gatggaaagc 721861 ggatcacccg cgatccaatc gctgaaagca ctaattttct cgatcaaaac ggaacggctg 721921 actctgttta tcaagtggcg gctgtcaata aaggacggga agaaaagctt tccaagaaag 721981 ctcgtgtttg gcaggaaaat gtcctggagg ttcctcttgc caaaccggaa ggcggtgtga 722041 cgccggacgg aaagccgtac acttacagcg ccaatgatgc cagtgtcggg gatatagacg 722101 gggatggaga atatgaaatg atcctgaagt gggacccgtc caattcaaaa gacaacgctc 722161 atgacggtta taccggggag gtgctcatag atgcctataa actggacggc acctttttgt 722221 ggcgcatcaa cctcggcaga aacatcagag cgggtgctca ttacacgcaa tttatggtgt 722281 atgaccttga cggtgacgga aaagcagaaa tcgccatgaa aacagctgac ggcacaacag 722341 acgggaaagg acatatcatc ggtgatgagc aggccgattt tagaaacgaa cagggcagaa 722401 ttttgtccgg tccggaatat ttgaccgtgt ttaaaggaga aaccggtgag gcgctcacga 722461 ccgtggaata tgaaccgccc cgcggcaagc tggaggattg gggagacggc tatggaaacc 722521 ggatggaccg ttttctcgcc gggaccgctt atttggatgg ggagcggccg agccttgtta 722581 tggcgcgcgg ctactatacg agaaccgtgc tcgtggcata cgatttcaga aacggaaggc 722641 tcaaaaaacg atgggtattt gactccaacc agccgggaca tgaagcatac gcaggacagg 722701 ggaaccacag cttgagcgtg gcggacgtcg acggagacgg aaaggatgaa atcatatacg 722761 gcgcaatggc tgtcgatcat gacggaaccg gcctgtactc aacgggcctc gggcacggag 722821 acgcgatgca tgtaggggat ctggacccgt cacgaaaagg gcttgaagtg ttccaggtgc 722881 atgaggacgc cacgaagccg tacggactgt cgctgcgaga tgccggaacc ggtgagatat 722941 tatggggcgt ccatgctgga actgacgttg gccggggcat ggcggctcat attgatccaa 723001 gctacaaagg atcgctcgtc tggggaattg atccgccggg caatgatggc atgtcgtacg 723061 ggcttttcac gagcaaaggc gaaaaaatca gcgacaaagc gccctcttca gccaatttcg 723121 ccatctggtg ggacggtgat ttggtcagag aactgcttga tcatgactgg gacggaacga 723181 tcggcaggcc aaagattgaa aaatgggatg ctgaaaacgg ctgtctgaag acgatatttc 723241 agccggccgg cgtgttgtcc aacaacggca cgaaaggaaa cccggttctt caggccaacc 723301 tgttcggaga ctggcgggaa gaagtgatat ggagaacgga agacagcagc gcgctccgta 723361 tctatacaac aacacatctc acccgccact gcttttacac gctgatgcat gatccggttt 723421 acaggctcgg catcgcctgg cagaataccg cctacaacca gccgccgcac acgagctttt 723481 acctcggaac gggaatgaaa aaaccgccga agcccgccct gtacatagcg ggaagcaaag 723541 cggaggcgcc gctgtaggag gactaaggga taagacgcaa aggctgaacg ctacgccaag 723601 atgattagag aactggcagg acgaaccaat gctcaagcgc tgtacgcacc ggttttttca 723661 agggaagagc tatccgtgat ggaagctgta taaaaaacga ggaggaatga aaaaatggca 723721 aatcatattt atcttgccgg cgattcgact gttcaaacgt atggagacag cacaaatcaa 723781 gggggctggg ggcagtttct cggctcgcat ctgccggagc atattcaagt gatcaacaga 723841 gcgatcgggg gaagaagctc gaaaacattt gtggaagagg gcaggcttca ggcaatcctc 723901 gatgtgattg agccggatga ttggctgttc gtgcagatgg gccataatga cgcgtcaaaa 723961 aataagccgg agcgctacac cgagccctat actacttata aacaatattt aaagcagtat 724021 atcgcaggcg cgcgggaaaa aggcgcccat ccgcttctca ttacccccgt agcccgcttt 724081 cattacgaaa acggcgtgtt tttgaacgat tttcctgatt actgcattgc catgaagcag 724141 acggccgctg aggagaatgt ccagctcatt gatctgatgg agaaaagtct cgctttcttt 724201 actgagaagg gcgaggaaaa agtgtacacc tattttatga tttcagaagg gattaacgat 724261 tacacgcatt ttacaaaaaa aggcgcaaat gaaatggcga aacttgtggc aaaaggcata 724321 aaggagctcg gcctgccatt gacagaatcg atcatcaaag aaaggtgaaa atgtgatgag 724381 aaaactgtat catggcgctt gctattatcc ggaattatgg gatgaagaga cgattcagca 724441 ggacattgac atcatgcgtg aagttggcgt aaatgttgtg cggatcggcg aatttgcctg 724501 gtcagtcatg gaacctgaag aaggaaaaat tgacgtcggt tttttcaaag aaatcatcgc 724561 ccggctgtat gatagcggga tcgaaacgat tatgtgcacg ccgacgccta ccccgccgat 724621 ttggttctca catggccggc ccgaacgcat gcatgccaat gaaaaaagag agatcatggg 724681 gcatggctcc cgtcagcatg cctgtacgaa caacccgtat ttccgaaaaa aagccgccat 724741 catcaccaca gccatcgcca aggagcttgg ccggctcccg gggctgatcg gatggcagct 724801 agacaatgag tttaaatgcc atgttgcaga atgcatgtgt gagacatgct tgcgcctatg 724861 gcatgactgg ctcaaaaatc gctacggggt aattgagcgc ttgaatgaag cttggggaac 724921 cgatgtgtgg agcgagacct atcagacgtt tgagcaagtc ccgcagccgg gaccggcccc 724981 gtttctgcat catgcctctc tacgcactat gtatcagctg ttttcgatgg agatgatcgc 725041 ttcgtttgcg gatgaacagg ccaaaatcat ccgctgctat tcagatgcgc cgatcacgca 725101 taacggatca gtcatgttca gcgtggacaa tgagcgaatg tttcagaatc tcgattttgc 725161 ctcctatgac acgtacgctt cgcaggaaaa cgcctctgcc tttttattga actgtgattt 725221 atggagaaat ctgaaacaag ggcgcccgtt ttggattttg gaaacgagtc cgtcgtatgc 725281 cgcctcgctt gaaagctccg cttacccgca cgcagacggg tatttgcagg ccgaagccgt 725341 atcgtcctac gccttaggga gccaggggtt ttgctactgg ctatggcgac agcagcgttc 725401 aggcagcgag atttcccacg gttcggttct cagtgcctgg ggcgaaccca ccatcggcta 725461 tcaaaatgtg ctggcggttg agcgggcaag aaaggaaatc gagcctatta ttctatcgac 725521 tgaacccgtt caagccgagg cggcgatgac ttactctgac agagcaaaag catttattaa 725581 aactgagcct caccggggac tccggcatcg ttcgcttgtg acgcattttt atgaacgtat 725641 tctcaacacg gggattcacc gtgaccttat tccggaaggc gctccactgg acggctatcg 725701 cttgctgttt acgccatttg tgccgtattt gtcttctgaa tttatcaaaa aagcttcggc 725761 attcgctgaa gcgggcggca tctggatcac cgggccgctg acaggaggac gcacatgcga 725821 gcataccatt cataccgatt gcggacttgg cgaacttgag aaaacgtcag ggatcaaaac 725881 actttttacc tttccgatga atgagaacgt gaatacagga aaagcgtttg gcatcacggc 725941 gccgctcgga ctgtggagcg cggtgtttga cacagagagc ggaaacaccc ttggcacggt 726001 tgaagcagga ccgggggcgg gccatgcttt tctgacggaa cggaattacg gcgaggggaa 726061 aattgtcatg ctgggctcgc ttccatccgg gaaagaaggg gatgcgatgc tggaagcgct 726121 cgtcaggcat tatgcggagg aagctgttat ttccagccgg tcggatgtga cacccggcac 726181 gatcgttgcc ccgcgtatag gcgaaaacgg ccttgtgtgg atcgttgtga atatggatgg 726241 aaaaggcggg agcgtgacat tgccggaatc gggaacggat ttgttgacgc accgcttgga 726301 aaaggcgggg agactggcgg tcggaccgca tgaataccgt gtgattcaat ttgacaatca 726361 cagctgattc tttgtatcga atcagctttt ttctatggag ggagagacag atgaaaaaga 726421 tcaaatggtt atcaggacag ccaaaggtga caagcggcgt gacgtggggc atgccatgga 726481 aaaaaggaga attaaaaaaa ggagaccgtc tggcgcttat gaatgaaaac gcggaaacgc 726541 gatatgtgca aagcgaaccg tcggcctatt ggccggacgg gagcatcaag tggacgaagc 726601 acgcggcggt gtttggcggt caggaaaacc aaagctttac agtgcacaaa agagaagtgc 726661 cgcagccaac tgaatcgctc agcattcttg agacagagca tgatatccaa gtggatacag 726721 gagcactcgt ttgtaccatt cataaaacag gatctgattt cattcaatca ttgcagatca 726781 atggaaagcc gatcgccgca ggcgggaggc tcgttgcgat aagagaaacg agaaaagagt 726841 cagcggcgaa aatggttctt ttgcatgaaa ggtctgtcag ctttatcaaa cgggcggcga 726901 ttgagcagag tggtcctgtc aaagcagtag tcaaaatcga gggagtgcat gtgcttcata 726961 aaacgtatga ggaatggctg ccgtttgtca tccgattaac gttttatgcc gggctgtctg 727021 agatcggcct tgtgcacacg cagctgattg acaggagcgg taaactagaa ttcgttaagg 727081 ggctcggcat cgaattcgac ctttttttgg agggagagcc gtacaaccgc catttccgct 727141 ttgcgggaga gaaagggatg tataaagaac ccgcccagct gtttggcaca cgtaaattca 727201 atgaacgata tccgctttat gaaaaacaaa tcaatggcga aatgctgtct ccagatgaag 727261 agcataagga atggtttgca catggcacac agaatgcggt ttgggacgat gtcaagatcg 727321 tgcaagattc cagcgatcat tacagcctgt caaaacggac cggaaaagat tatgcgtggg 727381 ttggaatgct gcatggcagc cgggcgaagg ggctctgcta tgcgggcgga aaaaatggcg 727441 gtgtggctct cggcctgcgg tatttctttg agaaatatcc ttcagcactg gaaatcacag 727501 gtcttgccgg cagccgcccc aaaatgacta tctggctttg gcctccggac ggcgaagcga 727561 tggatttgcg gcattataca ggaaacactc acgtggccag cgcgtatgaa ggctttgatg 727621 aaatgcgctc tgatccgaca ggcattgcga acacaaatga aataagcctg gcgtgctttt 727681 cgcacatgcc gtctgacgaa gtcctcaatg cgctggctga caaatggcag gcgcccccgc 727741 tcattgtatg cgagccggac gtctattacg aatcaaaagc actcggggta tggagcatca 727801 ttgacacatc ccatccgctc aaaaaagagc tggaagaaca gcttgatgcg gcctttctgt 727861 tttataaaaa ggaagtagag caacgcagat ggtacggttt ttggcattat ggcgatgtca 727921 tgcatacgta tgacccgatc cggcatatgt ggcggtacga tctcggcgga tacgcatggc 727981 aaaacaatga gctcgttccg accctatggc tgtggcaggc gtttttccgc tcaggcagag 728041 aggatatctt ccgaatggca gaagccatga cccgccatac gagtgaaacg gacagctttc 728101 acctcggtga atatgccggg cttggctcac ggcataatgt tgtgcactgg ggatgcggct 728161 gcaaggaagc gagaatcagc atggccgggc ttcataaatt ctattattat ctgacgggtg 728221 atgaccggac gggagatctt ttgacagaag tgaaggatgc cgattatgcc cttgtcaaaa 728281 ccgatccgat gcgcgctttt tacgagaaag gcaagcaccc gactcacgcc agaacgggac 728341 cggactgggc ggcgttttgc tcgaactggc tggcggaatg ggagcggacc gaaaattcgg 728401 aatatctcaa aaaaatcgaa acgggaatca actgtctgaa gcggctgccg ctccgcttat 728461 tatctggccc gacatttgaa tatgatccgg cgacctcgat gcttcatcat atgggagacg 728521 gcattgcggg cggatatcat atgatcattg ccttcggcgc gccgcaagtg tggatggagc 728581 tggctgagct tcttgatgac tgggaatggg aggatatgct gagtgaattc ggcgaatttt 728641 acacactcag tgatgaggaa aaacgaaaaa aaagcggagg cgctcttcat gacgggcatt 728701 ttcactggcc gatgttcgcc gccggtatga cagcctacgc cgcaagaaaa aagcaagatc 728761 ctcatctcgc cgccaaagcg tggaatcttt tgctagaaga taagctcagc catacgccgc 728821 ttccgatcaa accggagcgc atcgagacat ggacgcagct agaggagctt ccatgggtga 728881 caacgaacac tgtctctcaa tggtgtttaa atgtcatagc ggcgctggaa ctgatcggag 728941 attcccttcc ggcaaaaaaa gaaacatcgg gcaaaaaagg ataacagccg gaatttcata 729001 ggagaaatgg tgcaaaaaat gaagattgca agaatttatg taagcgcttt atattgagag 729061 gggcaaaggg gaaatgcaaa ttgaaaaaag ggggacttac gcaacatgaa aataagaatg 729121 cgaaaaaaat ggatggcctt gccgcttgct gccatgatga tcgccggatg cagccattcg 729181 gaaacatcca attcagcaag cggttcgaaa gatacgatca aaattatggc gccgctctta 729241 tcgccggaaa gcccaagtga taagagccct tcattaaaag cgctcgaaaa atacacaggc 729301 aaagagatta aggtcacatg ggtgcctgat tcatcctaca acgacaaatt caacatcgtc 729361 atggcttcag gagagatgcc tcacgcgatt gtcattaaag ataagtcagc cggctttatc 729421 aaatctgtca aagcaggggc gttttgggag ctgtctcctt atttaaaaga ctacaagaat 729481 ttaagccagg cagatgaaaa gattttgaag aacagctcgg tgaacggcga ggtgtacgga 729541 atctacagaa cgagggatct gatcagggcg tgtatgatca tcagaaccga ctggctgaaa 729601 aatgtcggtc tggatatgcc ggaaacgctt gatgatttct atgaagtgct gaaagccttt 729661 aaggaaaaag atcctgacgg aaacggcaag gatgatacgt acggcatggt cgtgccgaaa 729721 tggatgggac tcggcaacgg aagcccatgg gatgttctgc aaatctggtt cggcgctccg 729781 aaccgctacg gtgttgaaaa cggaaagctg attccagatt ttacaacgaa ggaatacatg 729841 gatgcgctca cgttttttaa aaagctctat gatgagggct tgatcaataa ggactttgct 729901 gtcatggatt ctgcgaagtg gaatgatccg gttgtaaaag gaaaagcggg tgtcatcgtt 729961 gatacaggct caagagcgtc tcaaatccaa agcgcgatgg aggaggcgga tgagtcgaac 730021 aaggatatca ttgatatcgt cggctcgctt gagggaccga atggcaagcg caccttcccg 730081 acatctggtt attcaggcat gatcacgata ccaaaatcaa gcgtcaaaac cgaaaaagag 730141 ctgaaagagg tgctgtcctt cctcgataag atgaatgata aggaagcgca gattctcacg 730201 aacaacggag tgaagggccg caattacgag ctcaaggacg gcgtattcac ctcacttgaa 730261 aaaaacaata aatctctcct gtatgagcat gaaggcttgg cacagttcag catgtcgatt 730321 ccgaaaagcg agtattacat cgaagaccag aaaaccaagc tcttccagca tcgcaaggac 730381 atcataaccg aaggagaaaa aatagccgtc tttaaccctg ctgagtcgct tgtatctgat 730441 gtctataccc aaaaaggagc ccagcttgac aacatcatcc tcgacgcgag aacacaattt 730501 atcattggag aaattgatga aaaagggttc gatgatgcgg tggagctttg gaaaaaaagc 730561 ggcggcaatg aactgatgaa ggacttgaac aaattgtacc aatcgtcaaa ataaaccgat 730621 gcgcctgcct ttcggcgggc gccccggtat cacgaaagga gaacagatat ggaaacagtg 730681 ccgaagaaga gagatgcacc tgttctcacc gctggaaaag gcatcagctg gatggctgcg 730741 ctcaaacggg acaaatggct ttatcttctt cttattcccg gtctgcttta tttcttgatt 730801 ttcaaatact tgccgatgtg gggtgtgctg atcgctttta aagactattc gccatatctc 730861 ggcttctgga aaagcgaatg ggtcggcttt gattatttca aagacttttt tatgaatccg 730921 gattttttcc ggctgctgcg caacaccctc atgctggcga gtctggatct tttgtttgcc 730981 tttcccgcgc ctctcatttt ggctctgctt ttgaatgagg taagaaaggc cgtgtataaa 731041 agatgtatcc aaacctttat ttacgtaccc cattttgtat catggacaat tgtggtcagc 731101 atcaccttcg ttttctttac tgtcgataca ggtgtgatca acaaattgat tatgagcctg 731161 acaggtgagc agatttcttt cttgtcggat gcagactggt tccggccaat gattgtgatg 731221 caaagcattt ggaaggagac aggctgggga acgattctat ttttggcagc gcttgctacg 731281 gttgatcaag agcagtatga agcggccatc atggacggag cggggcggtt caggagaatg 731341 tggcatatta cgctgccggc gattagaagc accattatcg ttttgttgat tttaagaatc 731401 ggcagctttt tgaatcttgg ctttgaacag gtgtatttga tgacgaactc actcaaccgc 731461 agtgtggctg acatcttcga cacgtatgtg tacatgatgg ggattaccca aggggcgtat 731521 agctacagca cggcggtcgg tttgtttaaa tcagttgtcg ggattatctt gatttttggc 731581 gccaattaca ttgcgaaaaa gtttgatcag gaaggattgt tttagaggag ggagaggtat 731641 ggctgaaatt cacacgatgc acaacaccaa agccggacgg gtgtttgacg tctgcaacat 731701 tctgtttctc ggcggtgtcg gcgcgattac cattttgccg tttttatata ttatcgccgg 731761 ttcctttgcg acagaagcgg aactcgccca gcggagcttc tttattttcc cgaaaacctt 731821 tacacttgat gcttacaagt atgtgttttc gacaccgacg ttccttcgaa gcatgggcgt 731881 gtccatcttc atcacggtgg ttgggacggc tgtacagctg ttttttacct tcacgatggc 731941 gtatccgctg gcgaaacggc atgtgaaggg acggaatctg ctgttgaatc tggtgatttt 732001 ctccatgctg ttttcaggcg gcatgattcc gacgtacctt gtcgtaaaat cacttggcct 732061 tttggatacg tattgggcat tgattctgcc gatggcgatt aatccgttca accttattat 732121 tatcaaaaac ttctttcagc agctgccgcg cgagctggag gaatcagcaa aaattgacgg 732181 ctgttccgaa atcggcgtct tctggcggat cgccctgcct ctgtcaaagc cagttattgc 732241 gacctttgcg ctgttttatg cggtcgggat ttggaatgat ttcttccacg ctctcttata 732301 tatcaatgac agtgcaaaat ggccgctgca aatggtgctt cgccaagtca caattttatc 732361 ggatttaacg gcgaccaatg gtgatacgat gcaaaatgca gttccgccgg agcagggaat 732421 taaactcgct gtcattgtca ttgcgacgct gccgattttg gcggtctatc catttttaca 732481 aaaacacttt gcaaaaggaa tgctgatcgg ttcggtgaaa ggctgagaaa gggagtgttt 732541 catatcagta cattagatca gattaagatt gcctatatcg gcggggggtc ccaaggctgg 732601 gccagaagcc tgatgagtga tttgtcgatt gatgaacgga tgtcaggcac ggtggcgctc 732661 tatgatcttg attttgaagc cgctcagaaa aatgaagtga tcggcaatca cagcgggaac 732721 ggcagatgga gatatgaggc tgtttctact ttgaaaaagg cgttatcagc cgcggatatc 732781 gtcattattt ccattttgcc gggatcactg gatgatatgg aagtcgatgt gcacttgcct 732841 gagcgctgcg gtatttatca gtctgtaggt gatactgtcg ggcctggagg gatcatcagg 732901 ggcttgcgtg ctgtgccgat atttgcggaa attgcccggg caataagaga ctacgcacct 732961 gaatcatggg tcattaatta tacaaacccg atgtctgtct gtacaagagt gctgtataaa 733021 gtgtttcccg gcatcaaagc gattggctgc tgccacgagg tattcgggac gcaaaagcta 733081 ttggcggaaa tggtcacgga aaggctgggg attgaggtgc cgcggcgtga ggatatccgc 733141 gttaatgtgc tcggcattaa ccattttaca tggatcacaa aagcctctta ccgccatatt 733201 gacctgttgc ctatattccg tgaattcagc gcgcactatg gggaatcagg atatgagctg 733261 gagggggaat gctggaggga cagcgtcttt tgttcggcac accgtgttgc gtttgattta 733321 tttgaaacgt atggcgccat ccctgctgcg ggtgacaggc atctggcaga gtttcttccc 733381 ggcccatacc tcaaacagcc tgaagtatgg aaatttcatc tcacacctat atcattcaga 733441 aaacaagaca gagctgagaa acgacaagaa acagaacggt tgatcgtgca acaacggggc 733501 gttgctgaga aagcttcggg agaagaaggc gtgaacatca tagcggctct tctcggattg 733561 ggtgaactcg tcacaaatgt aaatatgccg aatcaaggcc aggtcttaaa ccttcctata 733621 caagccattg tcgaaacaaa cgcattcatc acaaggaacc gtgtccagcc gattttgtcc 733681 ggagcgcttc cgaaaggtgt ggaaatgctg gcggctaggc atatatccaa tcaggaggca 733741 gtggcggacg caggtttaac aaaggatact ggcctcgcgt ttcaagcctt cctcaatgac 733801 ccgcttgtcc agattgaccg cagtgatgca gagcagcttt tcaatgacat gctccaatgc 733861 atcatgcaaa gctgagcttg ccgattagct ctttccggtt tagaaaggaa agcattgacc 733921 atactgatag tataatcaag aagtaggtgc tatcaatatg ggaaattatt taagtgttgc 733981 ggtagaactg gtctgcggtt taggcatttt atttatcatc ttaaagcttc tcgggaaaac 734041 ccaattttct caaattacgc cgtttgactt tatttctgct ttaattttag gtgaattggt 734101 cggaaatgcc gtctacgatc atgaaatcaa aatcaaagaa attatttttg cttcgctatt 734161 gtggggcgtg ctgatttata ttattgaatt tatcacgcaa aaaatgaaat catcgcgaaa 734221 gttcttggag ggcgagccga atatcgtcat ccgcaaaggg gagcttcaat ataaagtaat 734281 gaagaaaaat aagatagaca ttaaccagct gcaaagccta ttgaggcaag ctgggagctt 734341 ttcgatccaa gaagtagaat atgcgattct tgaaacaaac gggatggtca gcgtgcttcc 734401 aaaatcagac tttgacaaac cgacaaataa ggatttgcag attccttcga agtccgtttc 734461 tctgccgatc acgttaatca tagatggaga gattgtgcgg gataatttga aggaagcagg 734521 tgtggatgaa cagtggctga aacaagaatt gaaaaagaag aacattgata agacagagga 734581 cgtgttattt gcagaatggc ataaaaataa gccgctgtat actgtaacgt acgaacaaag 734641 cagatcaaca tgactcttag aaaaaagctt gcagcaaggc gcaagctttt tattgattgt 734701 atgtcccttg tttgacagca cgtacatggt acatgctcac ttcagtgctg atcagatagt 734761 caggctttgg tttgcctttg tttgctttat ggccggcgat atgcgcatcg cttttttccc 734821 attgcttcca gtgatcctct gattcccagc gaatcatgac aacaacttct tcatcaccgc 734881 ggcgcacatt tttctcaagc actgtcacat caattaaacc ttcttgtttt tcaatgattc 734941 cttcagcgct gaaacgttct atgactttat ctgcaaagcc ttctttaacc gtcatttttc 735001 tcaactgtac aaacatttgt ctcactccaa tcattctcac atatgaataa ttgtaaatga 735061 aattcattct caatgtcaaa gaaagcgcag ggcggaatcg aaccgccgtg cgcaacagtt 735121 tattctttta ataaaaacac atttccgtct tcgtccttaa attgaacgaa ggtgccccac 735181 tccatttgat tgggctcacc gagaaattct acaccgtttg tcttcatttt ctcgtatgta 735241 ccaaagatgt cttcgcattc aaacacaata gaagccttca tttgctctga gcctttcatc 735301 atggctttcg ggtaaatgac taaacgagtc tcggctcctt ttggcgcaac ctccagccag 735361 cttgcttcag gtcccattgg gtgatccgct gcaatatcaa agcctacctt ctctgtccaa 735421 aattgcttcg ctttctgctg gtcctcgaca tatacagcaa cagtgccaat ttgtttgatc 735481 atagggaaac ctccaagttg aaaagataat aatactataa cctgtttacg gccgaagtaa 735541 cataaaaaaa tcagccggga aaccggctga ttattaaaat gagcagctta caacatcgat 735601 gtgatttgtg tctaaggcga aataaaccca gcggcgccgt gaggaatccc aataaaagcc 735661 gccgacggat cttctgccaa ggatgatcgg gtaaaaccaa aatgagcggc cattggttaa 735721 ccagacatag gtaaatcgga aaaggcaagg acgaatggtg attggttcaa ctaacaaaac 735781 ggctccttga gaaccctgcg gttttggggg tttcgctggt atttgggaag gaggaggtcc 735841 ctgcggcgca ccgccgaagc ctgggctggc accgctgcca ataccagggc cggagccgcc 735901 gccaaagcct ggaacagcac caccgccaat gccaggaccg gagccgccgc cagagcccgg 735961 aacagcgccg ctgccaatgc caggccatgg atatcggtat tcatattcaa aagcaggcca 736021 aggctcataa aaatgccccg caaacatata aggatcaaca taatacatgt gataacgtcc 736081 tttctcattg taaactgtac attgcagttt atgcgggcgg actcttattg gtgcattcgc 736141 ctaaggatat gaagctggaa tgctctcaga gagcagaatc atttgatttt tctctagtct 736201 tattcacaat tccgatttat cattttataa tgaaagtgct tctattacga aaaaggagac 736261 agaccgtgaa tatcgatcaa ttattatatc aatatatcat agacaacact gcggatatta 736321 ctgagaaatg gttcagtttg cgttgccagc taaaaggcga gctatattcc gccagccatt 736381 taagtgaaga aacgaaaaca cttttaaccg agcagcatac atttaccaat ataacaatcg 736441 caagcgcatt tctggaggat caaaccgatt ttcaagaaaa catgacaaaa tgggcgcaaa 736501 acgttgcgaa aaacagggta gagcaggatg ttcaagtgca tgaggtcgta gaagccatat 736561 ccaattcaag aatctcattc tgggacgcag tcgccacatt tataaaagag aatcaggaga 736621 ttgtgacaaa tgaggatgca gaccgatgga accgcattgt gaatcagtcg ttcgataagc 736681 tgattattga attctccgag cagtaccaaa aattcatgct gatgaggctt acatctcagc 736741 aggaactgat ctcagagctt ggctgcccgg tcatttccat tgccgatgga atcgggatat 736801 tgccgcttat cggctccatt gatacaaaac ggcacaggtc attttagaaa cagtgccggt 736861 ccgctgtgtc gagagaaaaa tcacaagcct cgtcgttgat ctttcgggtg ttccgattgt 736921 ggataccatg gtggctcagc aattgtacaa cctgtctaaa acacttttct tattaggcgt 736981 caaagccgta ttttcaggaa ttcgcccgga tgtggcccaa acatcgattc aattggggct 737041 tgattttagt gaatatgaaa cgtacggcac gctgaagcag gcattagaaa acatgggtgt 737101 ccgctgtatt gttgaggaat tggaagaaaa caaataggaa gtttccaggc atatgattgt 737161 ccgtcaccgg gtgatcatat gcctttttga tttgaacaga aatcaccatt gatttatcga 737221 aaaaaacata atattataat tcttataaga atactgtgaa ttaaaaccta ttcaacaggg 737281 gggaaggtct tttggtttct aaatcaacga ttgatccgga agtgattgaa aaaatcatca 737341 gctcgctgga aacactcgat ttcggcacgg ttcagattac ggttcatgat tctcagatta 737401 cccaaattga gaaaatagaa aagcaccgtt tttcgctgaa aaggaaagaa tcaaaatgat 737461 aatgtaaagg gcgtttgttt tcattaaatt ctccttaaaa catatacata tttcatccaa 737521 tttttatata atagaccttt aagatcattt tttaggagga tttttgacat gcaagctacg 737581 gttcacgaga gtaagcaatc gatcatgcaa cgcattttga cagtctttgt cttcacattg 737641 ctgatcgcga ctgtcggcct ttttatcggc caatttgttc ctgtcgcttt gatgctgccg 737701 ctttctattc ttgaagtggc gatgattatt ctggccttct ggatgcgcag aagaaaagcg 737761 gtcgggtatg cgtttgtata tacattcgcg ttcgtttccg gcattacctt atttccgatc 737821 gtcagccatt acgcttccat cgccggcgcc tatgtcgtgc tcgaagcctt tggctctaca 737881 tttgtcattt ttgccgtctt gggcacaatc ggcgcaaaaa tgaagaagga tttatccttc 737941 ctgtggtcgt ttctgctggt tgcggtgctc gcactcgcag tggtagggat tttcaacatt 738001 ttcagcccgt taaactcagc ggcgatgatg gcgtattccg tgatcggaac catcgtcttt 738061 tccctttaca ttttgtatga tttgaaccaa atcaagcacc gccacattac ggaagacttg 738121 attccggtta tggcgttatc gctgtaccta gactttatca acttgttcat caacctgctc 738181 cgcttcttcg gcattttgag cagtgatgat taatgaaaaa gcgtctgtca ttggataggc 738241 gctttttgcc atacatcaaa aaggcaggtg gagtattggt gaaaaaacaa atgggcgcat 738301 atgtatctct ggcagcagct atggcgatcg tcggcagttc tgtcgttgtc ggcaagctga 738361 tggtcgaacg gattccggtc tttctttcct caggattgcg ttttttgatc gcttctgtcg 738421 tattgctcat gctgctgttt tgcattgaaa aagggtttcc ggctttgacg aaaaaagatg 738481 tgttcgtatt actggtgcaa tcattcacag gcgtgttttt gttcagtatt tgcctgctgt 738541 atggggttca atatacgacg ggaacggaaa gcggcatttt gacaagcaca acccccatgt 738601 tgatcggtat tttatccttt ttcctgctga gagaaaaaat tgagaaaaag acgctgatcg 738661 gcattttgct ggcggtttgc ggcgtaatgg cgattaattt gtttggagcc gggagccaag 738721 acgggacgcc gcacgcctta ttcgggaaca tgctgatcat tgctgcagtc attggcgaag 738781 cgttgtttac attgatggcc aagctgctat ccccgcatat ttcggcactg gcgatttcga 738841 ccttcgtatc gctcttcggc ttcctgtttt ttctcccgtt tgctttgttt gaggcctctt 738901 catttgatta cagcgtgccg actgttttgg attggtcgta tgtgctgtat tacgcgcttt 738961 ttgtcactgt tttggcgttt tacttatggt atagcggggt gacgaaggtg ccggcgggtg 739021 tatcgggcat tttcacatcc gttcttccgg tctcagctgt cattttgtca ggcgtgatat 739081 tgaaggagcc atttgagttt gtgcatttca tcggcattgc atgtgtcatc ggcggcatat 739141 ttgttacggt cataaagaaa aaacagccgg atgcgtatcc ggctgcagaa gaaaagacgc 739201 tatagcctgt ccggatcgga cgggtttttt agtctttaaa cacgctcagc ctttcaaaaa 739261 gatcaccaag catcttcacg aacatgtctt tttcctcgtc gctgtagttt tccatgacag 739321 cggatatttt gctgaaatgg ccgggcagaa attgctccag gcgtgctttg ccttctgttg 739381 tcagttcaat gctgattttt cgtttatcct ctgtgtgatg cctgcggctg acaaaaccgt 739441 ctctcgccag cccgtctagc aggcctgtaa ttgttgcttt cgtgacattt gaccgcttgg 739501 caagctctgt cggacttaac ctatgatcct tggcatcaaa gagcagcatc aggattttga 739561 attttccttc tgaaagccct cggccagcaa agtaatgctc catcacatga ttcatttttt 739621 ttgaaatatc aaaaagagat aaaaacaatt caagagagcc ggcgtcaata ttggcatacg 739681 tttcggcgtg ctctgttata tgcttatatt tcggtaaatg ttttaattcc atcgcaatta 739741 gctcccgtac attcgttgtg acacgattat aaaggaggga aaaccataac gcaacttggc 739801 ttggagatga ttgacagctt ttcttgggac atagtaaggt aatatagtta ggcgcctaac 739861 taatacatat agagctgaaa aggtggttat tgatatgaaa catatgttaa tagcaggagg 739921 cggaatcggc ggcttgtcag cggccatttc tctccgtaag gcagggtttt ccgtcacctt 739981 atgtgaagcg gcttcagaaa atcgaaaaac aggtgcgggg attcttcagc cgcaaaacgc 740041 actggcggtg ttgaaagaac tgggcgtatt cgaagattgc tgtaagcacg gctttcaaac 740101 agaatggttt aaaacgtttg atgaacaggg gaatttgctg tttcaagtca gtgaatcctt 740161 tttagacgat tcacttccgg gacgcaataa tatcctgcgc aaaacgttaa atgacattct 740221 catgaagcat gccgaggcag tgggtgtaga catcaagtgg gggaaaaagg ttgtcgccta 740281 tgaagaaact gctgaatcgg tcactgcctt atgtgaagat ggagaaaaga tgcaggctga 740341 cattctggcg ggctttgacg gcattcactc cgttgttcgt gataagatgc tgcaaaagga 740401 aacggaaaaa gagcatctcg gcatgggagc gtggcgcttt tatatcgaac ttcctgatta 740461 cacattcgag gacgcaacat tcatgtatag aagcggagac acacaaatcg gggtggtgcc 740521 attggcacaa cacgctggct atgtcttcgt cctccagcct tgcacgagcg attactggga 740581 tgaggaagat acccggtttg atagagtaaa agagattctt tctggttttc gggggctgga 740641 ttttgtcaca aagcacatgt caaaacagca tcctgtcatc tttaacaaac tggagcaggt 740701 cgccgtgcag gagccatggc ataaaggccg cgtcatcatc ggaggagacg ccgcccacgc 740761 cggtgcgcca accctggcac aaggagcggc aatggcgatc gaggatgcca tcgtcctcgc 740821 cgaagaactc caaaaccacg ccgaccacga aacagcatta caggcgtact ataaaagaag 740881 agccccacga gcgctcaaag tccagaacct atcatctgaa atcgtccgcc gcaggctgaa 740941 aggagagccg ggagcggaag aactgattgg ggagtgctat gcggtgttga gggaagggta 741001 ttaaatagga aaagtccaga aagtgatttc tggacttttt agtcttgctc tgttttattc 741061 cttatccgct caatcacctc atgcagcccc tcaggcttat aaaactccac cggtgaactg 741121 cctttctcaa acgaaatcgt ctcggcttca atcagcgcga catagcgccc gtttactttt 741181 gcgagatgaa tagaatcgcc aaaatccgct agcaatccct taatctctgt ttctccgact 741241 ttcattttca gctgggcctc tggcgtgtgc tcgatgattt gggcggaggc ttcgatgact 741301 tgatgggtgt cgaggcgctc ttggatttcc cgtttttcgc ttgcttccca aatctcaatg 741361 tcgtgctcga actgcttgag ttcttcgctg ttgtcttcaa atgtctcgta gacgtgctct 741421 tgtaccatgt tcatgacctg atttttcatg atttctggca tcgattctcc gtactcgacg 741481 aatttcagaa agtcctcaaa atagcgggcg tgcgaggcct ggtggatttt cagttcacct 741541 tcctcgacca ttccttcctc tggcatgtac gggtattgga tgcttttcat gttttttgtc 741601 gtgatcgcca tttcgacttt tttaatgaga gaagacgcgt cagagatgcg ggcgaccttc 741661 ggctcaaaat cacatttcat aatgaagaca aatgactcat caaagtattt tctcggcacg 741721 gccgaagcga cgagaaacac gccgccgcga accgcgcttg tgtcaaggta cgtgcggacg 741781 aactgctcgc tcagctcatt gaagtcttct tttgtttccg ccagacgcgc gcggttgaac 741841 atgttgtagt ttgggttgga atcgagctcg tggccgggct cgacgataaa atggccgatt 741901 ttcgtcggca cctgctcgga ctgcggatgg cggtcggctt tccgtttaac gatttttttc 741961 agttccccgt cgagaaagtc cttcagctcg ctttcttcaa attctcccgt atcaagggtc 742021 tggaagtgct tgaactgctt gttcgcctgc tcatctttgc cttccacctg tatgacataa 742081 aaggataaaa accgaatttc aaaatccata tataaactca ccttattcgc gtattgtaca 742141 gcttctcaag tatagaaaaa acagcgatca tgcgtcaatt gggagaacgg aataatcatg 742201 accatgaaag ggaaatgtag tcaaatagaa ggcatttcat acggaaagga atggttcgat 742261 gaaggaaaca agcccgattc ctcagccgaa gacgtttggg ccgctcggca atttgccttt 742321 aattgataaa gacaaaccga cgctttcgct gatcaaactg gcggaagaac agggcccgat 742381 ttttcaaatc catacacccg cgggcacgac cattgtagtg tccggccatg aattggtgaa 742441 agaggtttgt gatgaagaac ggtttgataa aagcattgaa ggcgccttgg aaaaggttcg 742501 cgcattttcc ggtgacggat tgtttacgag ctggacgcat gagcctaact ggagaaaagc 742561 gcacaacatt ctgatgccga cgttcagcca gcgggccatg aaggactatc atgagaaaat 742621 ggtcgatatc gctgttcagc tcattcaaaa atgggcaagg ctcaacccga atgaagcagt 742681 cgatgtcccg ggagatatga cccggctgac gctcgacacc attgggctat gcgggtttaa 742741 ctaccgcttt aacagttact acagagaaac gccccacccg tttatcaaca gcatggtgcg 742801 ggcgcttgat gaagcgatgc atcaaatgca gcggcttgat gttcaagata agcttatggt 742861 cagaacaaag cggcaattcc gctatgatat tcaaacgatg ttttcgttag tcgacagcat 742921 tattgcagag cgcagggcga atggagacca ggatgaaaaa gatttgctcg cccgcatgct 742981 gaatgtggaa gatccggaaa ctggtgaaaa gctcgacgac gaaaatatcc gctttcagat 743041 catcacgttt ttgattgccg gccatgaaac aacgagcggc ctgctttcct ttgcgactta 743101 ctttttattg aagcatcctg acaaactgaa aaaggcgtat gaagaggtcg atcgggtgct 743161 gacggatgca gcgccgacct ataaacaagt gctggagctt acatacatac ggatgatttt 743221 aaatgaatca ctgcgcttat ggccgacagc tccggctttc agcctttatc caaaagaaga 743281 cacagtcatt ggcggaaaat ttccgatcac gacgaatgac agaatttctg tgctgattcc 743341 gcagcttcat cgtgatcgag acgcttgggg aaaggacgca gaagaattcc ggccggaacg 743401 gtttgagcat caggaccaag tgcctcatca tgcgtacaaa ccattcggaa atggacaacg 743461 ggcctgtatc ggcatgcagt ttgcccttca tgaagccaca cttgtgttag gcatgattct 743521 aaaatatttc acattgattg atcatgagaa ttatgagctt gatatcaaac aaaccttaac 743581 acttaagccg ggcgattttc acatcagtgt tcaaagccgt catcaggaag ccattcatgc 743641 agacgtccag gcagctgaaa aagccgcgcc tgatgagcaa aaggagaaaa cggaagcaaa 743701 gggtgcatcg gtcatcggtc ttaacaaccg cccgcttctc gtgctgtacg gctcagatac 743761 cggcaccgca gaaggcgtcg cccgggagct tgctgatact gccagtcttc acggcgtaag 743821 gacaaagaca gcacctctga acgaccggat tggaaagctg ccgaaagagg gagcggttgt 743881 cattgtgacc tcgtcttata atggaaagcc gccaagcaat gccggacaat tcgtgcagtg 743941 gcttcaagaa atcaaaccgg gtgagcttga gggcgtccat tacgcggtat ttggctgcgg 744001 cgaccacaac tgggcgagca cgtatcaata cgtgccgaga ttcattgatg agcagcttgc 744061 ggagaaaggc gcgactcggt tttctgcgcg cggggaaggg gatgtgagcg gtgattttga 744121 agggcagctt gacgagtgga aaaaaagcat gtgggcggat gccatcaaag cattcggact 744181 tgagcttaat gaaaacgctg ataaggaacg aagcacgctg agccttcagt ttgtcagagg 744241 gctgggcgag tctccgctcg ctagatcgta cgaagcctct cacgcatcca ttgccgaaaa 744301 tcgtgaactc cagtccgcag acagcgatcg aagcactcgc catatcgaaa ttgcattgcc 744361 gccggatgtt gaatatcaag agggcgacca tcttggcgta ttgccaaaaa acagccaaac 744421 caatgtcagc cggattcttc acagattcgg tctgaaggga accgaccaag tgacattgtc 744481 ggcaagcggc cgcagtgcgg ggcatctgcc attgggccgt cctgtcagcc tgcatgatct 744541 tctcagctac agcgtcgagg tgcaggaagc agccacaaga gcgcaaatac gtgaactggc 744601 gtcatttaca gtgtgtccgc cgcataggcg cgaattagaa gaactgtcag cagagggtgt 744661 ttatcaggag caaatattga aaaaacgaat ttccatgctg gatctgcttg aaaagtatga 744721 agcgtgtgac atgccgtttg aacgattttt agagctttta cggccgttaa aaccgagata 744781 ctattcgatt tcaagctctc caagagtgaa tccgcggcaa gcatcgatca cagtcggtgt 744841 cgtgcgcggc ccggcgtgga gcggccgtgg cgaatacagg ggtgtggcat caaatgattt 744901 agctgagcgt caagccggtg atgatgtcgt gatgtttatc cgcacaccgg aatcccggtt 744961 tcagcttccg aaagaccctg aaacgccaat tattatggtc gggccaggca cgggagtcgc 745021 gccatttcgc ggtttccttc aagcccgcga tgttttaaag cgggagggca aaacgctcgg 745081 tgaggctcat ctctattttg gatgcaggaa cgatcgggat tttatttacc gagatgagct 745141 tgagcggttt gaaaaagacg gaatcgtcac tgtccacaca gccttttccc gaaaagaggg 745201 catgccgaaa acatatgtcc agcatctcat ggctgaccaa gcagatacat taatatcaat 745261 ccttgaccgc ggtggcaggc tttatgtatg cggtgatggc agcaaaatgg ccccggatgt 745321 ggaggcggca cttcaaaaag cgtatcaggc tgtccatgga accggggaac aagaagcgca 745381 aaactggctg agacatctgc aggataccgg tatgtacgct aaggatgtct gggcagggat 745441 atagataaag aagactggag acatccagtc tttttagtcc tttcgaaaaa atggtgatcg 745501 cgctaaacat tgatgcatac aataacttca gtccgccgga agggcgggct gtctgcaaaa 745561 cctatttttc gtttttgcta gtttatgtta ttcttatact cggtatctat ttcttttttc 745621 aaaggcacac atgacaaaag aaatcctttt tttatttccg agaaaaaaat gtgaaacgaa 745681 atgaaggttt ctttcgtcca gtgattggtt tccaaatggt tgtaataaaa atgatatggt 745741 gcgaaacata aatattccgg cttgccgcgg tgtatttatt gttgtgtgat gccttgattt 745801 tgtttggaaa gaaggaattg gaaggcagga tataaagagc aggtaaatat gaatgaagaa 745861 cttaaagtgt ttaagaaagt agaggttgcc atgaagaaac ttttttctta caaacttagc 745921 ttttttgtgc tggctgttat actgttttgg gcaaaaacgt atttatccta caagactgag 745981 tttaatcttg gggtaaaagg cacaactcag gagatcctcc tgatatttaa cccattctca 746041 agcgccgtct tctttttagg actggctttg ctggcgaaag ggcgtaaatc agccattatt 746101 atgctgatta tcgatttctt gatgacattt gtgttatatg caaatatttt attctatcgt 746161 ttctttgacg atttcttgac gttcccgaac attaaacagt ccggaaacgt tggaaacatg 746221 ggagacggga ttttcagtat catggccggt catgatattt tctatttctt agatattatc 746281 attttgattg cggtattgat ctggagacct gaattaaaag aatacaaaat gaaaaaacgc 746341 tttgcatctt tagtgatcct ttctgggatc gcactgtttt tcatcaacct gcactatgcg 746401 gaaaaagacc gtccgcaact gctgacaaga acgtttgacc gcaattatat tgtgaaatat 746461 ttaggtttat acaactacac catttatgac ggtgtacaga cggctcaaac agagacgcaa 746521 agagcctatg caagcagcga tgatttaaca agtgtcgaga attacacgac gtctcattat 746581 gcgaaaccaa acgccgagta cttcggctct gccaaaggca aaaatatcat taaaattcac 746641 ctcgaaagct tccagtcatt cctgattgac tacaagctaa acggtgaaga ggtgacgcct 746701 ttcttaaata aacttgcgca cggcggggaa gatgtgacgt attttgataa cttcttccat 746761 cagacaggcc agggaaaaac atctgatgcc gagctgacaa tggataactc gatcttcggt 746821 cttcctgaag gctccgcgtt tgtgacgaaa ggcgaaaaca cctaccagtc gcttcctgcg 746881 attttagacc agaaggaagg ctatacaagc gccgtcctgc atggtgatta caaatcgttc 746941 tggaaccgtg accagattta caaacatatc ggatatgaca agttcttcga cgcaagcacg 747001 tatgatatgt cagatgaaaa tgtgattaat atggggctta aggataagcc gttctttaca 747061 gaatcgattc caaagcttga atctcttaaa cagccatttt atgcgcattt gattacattg 747121 acaaaccatt atccgtttaa ccttgatgaa aaagacgcgt ctcttaaaaa agcgacaaca 747181 ggcgataaca cagttgacag ctacttccag acagcgcgtt accttgacga agcgcttgag 747241 caattcttca aggagctgaa ggaagccggc ctgtatgaca actcagtcat catgatttac 747301 ggtgaccata acggtatttc tgaaaaccat aaccgagcga tgaaagagat tcttggaaaa 747361 gagatcacag attatcaaaa cgcacagaac cagcgtgtgc cgctgatgat ccgcgttcct 747421 ggcaaaaaag gcggagtgaa ccatacgtat ggcggcgaaa ttgacgtcat gccgacactt 747481 ctgcacttag aaggaattga ttctcagaaa tatatcaact ttggtactga tttattctct 747541 aaagaccacg acgatacggt ggcattcaga aacggagact tcgtaacgcc gaagtacaca 747601 tcagtcgaca atatcattta cgatacgaag acaggtgaaa aactgaaagc gaatgaagaa 747661 acgaagaatc tgaaaacaag agtgaaccag cagctgagcc tttcagacag tgtcctgtac 747721 aaagacttgc tgaggttcca taaactaaat gatttcaaag ccgttgatcc gtcagactat 747781 cattacggca aggagaaaga aatcaaataa gatgaaaaag agccttgagc gggcgcattg 747841 ccttcgctca aggctctttt tttggttata caaccaactt gaaaaaatag attccatttg 747901 gtcaccaagg ctggctttct ctcatatcat tacagtagat tttgaaaccg gattgaaatc 747961 ggacaaatta tcggggaaat gccttgatag attgtgaaga tgtaccaggt ttcgaactca 748021 atattcatag agatgagggg tagagatgaa agcggtcatt ctctgcggcg gaaaaggaac 748081 gagaatgagt gaagtcacga atgacattcc taaaccgctc gccatgatag gcggcaaacc 748141 gattctatgg catattatga aaatttatca gtactacgga gtaaacgagt ttattctgct 748201 tttgggctat aaaggagaaa aaatcaagga atactttctc gactatgaat ggaagcacaa 748261 cagcctgaca ctcgacagct ctacgggaga ggtacagatg ctggggcagc ctgaaacgtg 748321 gaaaattacg tttttggaga ctggggtaga tacgctgaca gccggaagaa tcttgcaggc 748381 gaaagactat atcggtgatg aaacatttct gctcacctat ggagacgggc tggccaatat 748441 caatcttttc catctcatca gctatcatca gacaaaaggt gctgccgcga ctgtcaccgg 748501 cattgacaaa gtctcgcagt ttggcacctt gacagttgag gatggcatgg cgaaaacatt 748561 ttctgagaag acatcaagtg atggaatcat caacggcgga ttcttcgttc ttagtccaaa 748621 ggttttcgat tatttgccga aggacgggaa cacgatgttc gaagatgaac cgctgaagaa 748681 ccttgccaaa gatggggagc ttgctgtgta ccgccattac ggattttgga cggccatcga 748741 tacgtataaa aatctcttag aagtcaacaa aatgtggaat caaggacaac aagtatggaa 748801 ggtatggtga attgatttga gtttctggaa aaataaaaac gtatttgtca cgggatgcac 748861 aggtctttta ggaagctatt tggtgaaaga gctgatcgaa cagggcgcaa acgttacggg 748921 gctagtcagg gatcatgtgc ctcaatccaa tctttatcag ggagaacata tcaagaaaat 748981 gaacatcgtg cggggctctc ttgaggactt ggctgtgatt gaacgcgcgc ttggcgagta 749041 tgagatcgac acagtctttc atcttgctgc acaagcgatt gtcggcgtgg caaaccgcaa 749101 cccgatttct acctttgaag cgaatatcct cggcacctgg aatattctcg aagcctgccg 749161 caagcatccg ttaattaagc gggtcattgt cgcttcaagt gataaagctt acggcgatca 749221 agaaaacctt ccatacgatg aaaacatgcc gctgcaaggc aagcacccgt acgacgtctc 749281 aaaaagctgc gcagatctga tcagccacac ctattttcac acgtacgggc ttccggtctg 749341 cattacgcgc tgcggaaact tatacggcgg cggagatttg aacttcaacc gcatcattcc 749401 tcagacgatt cagcttgtgc tgaacgggga agcgccggaa atccgaagcg acggcacatt 749461 tgtacgggac tacttctata ttgaagacgc cgttcaggct tatctgcttc ttgcagaaaa 749521 aatggaagaa aacaatcttg ccggagaggc ctttaacttc agcaatgaga tccagctgac 749581 cgtacttgaa ctggtagaga aaatattaaa gaaaatgaac agtaatctga aacctaaggt 749641 gctgaatcag ggaagcaatg aaatcaaaca tcaatattta tccgcggaaa aagcaagaaa 749701 gctgctgaat tggacaccgg cctacactat tgatgaggga cttgaaaaaa cgattgagtg 749761 gtatacggaa ttcttcaaaa agtaatgtga aacgaggtga acaagactgt gaccagcgcg 749821 tattgcaccg ttttatcaaa aggaagatta tatcaggcag tcgctttgtt taagtcgtta 749881 gagcaagttg atcaagacag tcccattttt atactttgca tggatgaaga tacgcaccgc 749941 gtgttacaga agctgaagat gaagcagctg aaccttgtgc cggtggccgc tcttgaaaat 750001 gaattgctgc tgaagctgaa ggaaactaga gatcaaagtg agtattgctg gacgatgaag 750061 ccgatctttc tgcaagctgt gctgaacagc aatcctgagc tggagcgtgt gacgtatatt 750121 gacggggatc tctttttcta tgcagatcca tcgccgattt ttgaaaacca gccggactgc 750181 tcggtgttgc tttcacgagg ggatattgta atcccttctt ttgagaaaga gcagattgac 750241 atgctgcagc gtcttttagg cagatataat tccgggttta tcagcttcaa gcatgatgat 750301 gcaggcacgg attgcttgga gtggtggaag gaacgctgtc ttgaggaatg caaaaatgca 750361 ccgggtgaag ggaaattcgg tgatcagggc tatttggatt atatgtctga gctgtttccg 750421 aatgtgtgtg acattacaac acccggcgtg aacatcggcc attggaatta tggacagcat 750481 acgttttcct ggaaagatgg ccggatcgtg ctggaggatg gcagtccgct gatcttttat 750541 catttcagcg gataccgaat cgtcagcatc aatgaaatca aacagattca tgaaacaacc 750601 cgcacagatc tgccgtttgt gcatgaactg tatcaagaga cactgccgca tatcattcag 750661 cacatgcaaa cgttagaccc tgaatttaac ggttttgctt caaaagatga caacaaataa 750721 atgagtaaat acaggaagtg aaaatgaagt gaaagcaagc gttattattc ctgcatataa 750781 ttcgaaggag cgtctttaca acagccttct gtcattaaac cagcaggagt gcgatgaaga 750841 atttgaagtc attgtagcgg acaatggctc tgaggacggg acgctctcga tgcttgagtc 750901 atttcaagct gattttccgc tgatctttac acggattaaa gaaaacaggg gcattgcgta 750961 cggacgaaat caggcgcttc gcaatgccag aggagacatc ctgattttcc atgacagcga 751021 tatgcttgcg gcaaaggacc ttgtggcaaa acatattaaa gcccatgaga acgaagagaa 751081 tctcgtcgtg tgcgggttgt tttggaaacg gatctacagt ttttactatg aacgatttga 751141 agaagaacat aaggaacagc tcgcaaagct cacaggtgaa atgccgaaga aagacaaaca 751201 aaagctgctg gaggaagcgg acatcaaaaa cggaagcttt cttgataaaa gctttgacct 751261 cgataccgac tttatagacg tgctcaagaa gattttagat gagtacggcg atgacttgaa 751321 aggctatcat atgccatggc gcttttttat cacgaataat tcctctgtga aacgcaagca 751381 tgtggttgac ctcggtttat ttgacgaagg cattgtgcgg tacgggtttg aggattatga 751441 cctcgggatc aggcttcatc aggccggatt gaccttcagg cttcgccgtg atattgtcag 751501 tgttcatcag gaacatccaa gcaattgtaa gtctgtagac gatattcggg caaacattgc 751561 ctatatgtgc gataaataca ataacatccg ctccttagac gttcatctcg cttttaatgg 751621 gccgttcccg cctgacatga cgaacagaat catggctgat attcaaaagc tgctggaatc 751681 acagaaatat gatatgctgc tgaatctgtt tcttgagctt ctgcatgttg ttaaagagcg 751741 caacattgat ccggattggc gaaagaaatc cccaagggtg acggcgaaaa gctttgattt 751801 gcaaactgtc cgcaagcttc tgcctaaggc gaagaaaaag ctaggcgtga acgattttgc 751861 caacgcactg tatgcgcttg tcaacgattt gctgcacgtg gatcttagat cattggatgt 751921 ggtataagtg agtacatttc atttttcaac gatagtgtca aggacacata tctttaagct 751981 catgcctatg attcattctc tccatgagca ttgcgatgat tttcatttat atgtgctgtg 752041 tgtcgaccag aaagcgtatg aattgcttca gcacgttcca tgggagcatg taacctttgt 752101 gcagctgcat gaaatggaag acccggagct gttgaaagcg aaaagcaaca gaacgtttca 752161 tgaatattgc tggacgttaa agcccgcctt tttgtttcat gtgatgagca agtgggatga 752221 cgctgaatac tttgcccata tggatacgga tctatttttc ttttctgatc cggcacgtat 752281 ttttgcagaa aacccaacgg cgtctctgta tttgactgat catcgtaatt cgccgcgctt 752341 catgtcctac tacgaccgaa ccggacgctt taatacaggc tttgtcggcg ccggtaatac 752401 aaaggaagca tatgaagcgg tgtggcagtg gagacaggac tgtattgaat tttgcacggt 752461 cgaaatggat acggaacgaa agacatatgg tgatcaaaga tatgtggaga aatggccgga 752521 gcagtttaaa ggtgttcatg ttgtcaaatc cataggagcc aatacagcgc tttggaatat 752581 cgaaaactat aaggtcgggc aaaaggacgg ccgcgtgtat atagatgaaa cgccgctgat 752641 tttctatcat ttctctgggt ttacgctggt gacagaaaaa gagtttaatc tttgctggta 752701 ctaccggatt gaagacgaag cgacaattaa gatgatttat atgccctata tattaaatct 752761 gaaaagatgg attgatgaaa tacagtcggc gtttccggac tttgcggatg gctttatccc 752821 gaagcacgca gtgcctgaca ctcattttat ccagctggat taaaaaaccc cctgccgcct 752881 ggcaggggtt ttttcagcta tgccattctc tcagcttctg gtcacttggc aataggaagg 752941 caaggatgcc gaggacaggg agaaaggcaa tggcgatcat cgtcggggtc agtcccgcgg 753001 catcaatcag agcgcccagc gccacagcgc cgattgcgcc catcccgaag gcaagcccga 753061 cggttaaacc ggacattgtg ccgatttttc caggaactag ctcctgtgcg tagacgaccg 753121 ttacagaaaa gctcgacatc agaaccaagc caatcaatgc gagcacgccg taggcgagaa 753181 ccgggccggc aaatggcagc acaatcgcca gcggcgccga gcataacagc gaaccgagga 753241 taacgaagcg ttttccaaaa cggtctgcaa gcgggccgcc gagaaacgtg ccgatcgcgc 753301 cgaacagcaa gaagacaaaa atatagcttt gtgcctgctg aatgcttacg tgataggtat 753361 ccatcgcgta aaacgtgtaa aagttaccga tcgcactcgt ataccaagaa cgagcaaaaa 753421 tgagaaatat aataataata agagcagata caacagattt ggtgatggcc gtgttttcag 753481 ccgttttctt ttgcttgcct gatttctggg caaggctgcc gagacgtgag gcgtaccatt 753541 tcgcaatata catgagaaac ataacagcaa gcgcggcgac aagcgtgaac caaacagcgc 753601 cgaattgccc gagcggcaca aggatcagcg cggtgatcag cggtgccatc gcctggcctg 753661 agtttccgcc cacctgataa atcgattggg cgagcccgcg ttttgtgccg gcggccatat 753721 acgccacacg ggagccctcc ggatggaaaa tggccgagcc taatccaatg aaaaacacac 753781 agcataagat cgttatgaat gacggggcaa atgcaaggcc caaaatgcca agcatgctgg 753841 cggtcaaacc gactggcagc gcatacggcc gcggccgttt atcggtatac cagccgacaa 753901 caggctgcat gacggatgac accatgttta atgtgaaagc aatgatgccg agctgtgtaa 753961 acgtcaggct catggagcgt tccaaaatag ggaacatggc cggaatcaca gcctgaagcg 754021 aatcgttgag catatggcaa attccgataa taatcaaaat cggatacacc gtggtgcctg 754081 gtttttgaac tgttttttct tttaacgggg cggcgatagc cattgagtct cctccttaca 754141 tatataacca aagcatacca ccatattatt cataaggtga agaatttatc aagaggaaaa 754201 aagattctta tgaaagaaat accgtcagcc tgattagcag ctgacggtat tttcgatatt 754261 caaaatgtga tatagctctt caagcttacg aatctcatag gttggtatga tctctggcac 754321 attcggcttc atgtcagggt tcatccagca agtatcaagc ccggcgagct gtccgccttt 754381 gatatcagca gttagtgaat ccccgatgat taatgtgtgc tctgctgaaa attgaggaat 754441 ccgttcaaac acgtaattga aatattcctt catcggcttt tggaagccgg tgtcttcaga 754501 aacgaaaatg tccttgaaga atggaaataa tcctgaatca cggagacgct tatattgtgt 754561 gtgagacacg ccgtttgtca cgatgtacaa atcaaactgt tgctgcagat ttgagatgag 754621 atcaaatgca ccgtcaataa gctgatgtcc ttcttcaaga aagcggcggt atttttgctc 754681 aagcaaagcg ccgtccgctt cgtaaccgta ctccttgagc aaagcggaaa aacgtgtgtt 754741 tacgacttca tcccgtgtca tcttaccttc ttcaaaggct ctccagagac cttgattgat 754801 ggttttatac tgcgccttca tgtcatttgt taaaggaatg ttctgatctt caaacagcaa 754861 acgcagggct aaagcttctg ccgcttgaaa atcaaggatg gtatcatcta catcaaataa 754921 taaagtgcgg tatcgcttca tctgtgtgtc tccctttctc atatgtattc aaagtatagc 754981 acataaaaaa aggaaaaagc cggcgggtga ggcaccgccg gctgaaaaga gattatttgt 755041 ttaataagct gtgttttctc gaatatagga agtaaaccag cgttccgaca gcgatccaga 755101 tgacaaatga aagccatgtg acgccgggaa ggctgtacat gaaccaaagg cagatgcctg 755161 cgctgataat cggcacaacc ggaacgaatg gcactctgaa ggacgctttg atttcaggat 755221 gtttctttct taacacaatg acagcaatgg aaatgaccgt aaacgcggca agtgttccca 755281 tgttcaccag atgggccagc gttccgaggt taataaagcc ggcgattccc gctgcaacga 755341 tccctgtcag ccatgtgttg cggaacgggg ttttaaatga cggatgaacc tttgcgaaca 755401 atccaggcag aaggccgtct ctgctcatgg caaatgtcaa gcggacctgt gcgtacagca 755461 aagcgagcat caccgtcgta atcccgataa tcgcaccgac agaaataatt ccggcaacag 755521 cgtcctgtcc gacgaatttc agcgcaaagg atacaggatc tccgacattc aatttggcat 755581 aaggcatcat gcctgtcagc acaagcgata ccgcgatgta cagaaccgta cagacggcta 755641 gagctgaaat aatgccgacg ggcatgtttt tttgcggatt tttcacttcc tctgatgcgt 755701 tagaaaccgc gtcaaaccca aggtacgcga agaatacagt ggcagcgcta agtatgacgc 755761 ctttcatccc gaatggcata aaaggagacc agttatccgg tttcacatag ccgatgccga 755821 caataatgaa caataatatg atcgcgattt tcatcagtac gatgacgttg ttaaagcgtg 755881 tgctttcctt gacgcctctg ctgacaatcg cagtgatgag gagaatgatc accgcagccg 755941 gaaggttaaa tacggcgccc gccatgcttc ccggcgctcc tgtcagtgca gccggaatat 756001 gaagattgaa gccggcaagc agtgattgaa agtatgaaga ccagccggtg gcaaccgccg 756061 acagtgcaat gacatattca agcatgagat cccatccgat caaaaaggcg agcagctctc 756121 caagtgtcac gtatgagtat gagtacacgc ttcccgaaat cggaatggaa gacgaaaact 756181 cagcataaca gaaagcagcc agcgcacagg cgagccccgc taaaataaac gatatgatga 756241 gggcgggacc tgcaccggtc gctgccactg ttcctgtaat gacaaaaatc cctgtaccga 756301 tgacacaacc gataccgagc aaggttaaat caaatgcgct taacgtacgg gcaaggcttt 756361 ttgacttgct ctgcgcactc aatgtttcaa gcggtttttt tctaaataat gaactcatca 756421 aaagttcctc ctagaaatat tcaaaatatt ctaatcatta tatgcagttc ttgttgtatt 756481 atattgtcga aatttgacgt agtcaataaa atatttttct gctttaaatg atagaagcga 756541 aacagcgttg tcgtatcata ggatagtaat ttttactaat cgtatattca attttatgca 756601 agatgaaccg atagaaaaaa tagattcgcc catattttga tttgcggtta taaaggagat 756661 gctgaccatg tttcaatatg aagagttgaa taaacagttt atcggcggga aatggcagga 756721 gggcagcagc ccaaatgtat tggaaaacaa aaatccttat actcaaaaaa cattcacaac 756781 attccgtaaa gcgactgctg acgatgtaga tgaagcgtat cgggcagcgg cgctggcaaa 756841 gaaaaaatgg gatgcggtca acccgttcga gaaaagaacc attttagaaa aagccgtcac 756901 gtatattgaa gaaaatgaag aagccattat ttatttgatt atggaggagc taggcggtac 756961 aaggctcaaa gcagcttttg aaatcggtct tgtcaaaaac atcataaaag aagcggcaac 757021 gttcccaatc cgcatggagg ggaaaattct tccgtcaaca atagatggca aggaaaacag 757081 attatatcgc gtgccggcag gcgttgtcgg tgtcatcagt ccgtttaact tcccattctt 757141 tttatctatg aaatcagtgg cgcctgcact cggagccggc aatggcgttg tgctaaagcc 757201 gcatgaggaa acgccgattt gcggcggaac gctgattgcg aaaatttttg agaacgcggg 757261 aattccagcg gggctgctga atgttgttgt cacagacatt gctgaaatcg gcgacagctt 757321 cgttgagcat ccagtgccgc ggatcatctc atttaccggt tctacgaaag tcggcagcta 757381 catcggacag cttgcgatga agcattttaa aaagccgctt cttgagcttg gcgggaacag 757441 cgccttcatc gtacttgagg atgcagatat agaatatgcg gtcaatgcgg cggtgttcag 757501 ccgatttaca catcaagggc agatttgcat gtcagccaac cgcgtgcttg ttcattcttc 757561 tatttatgac aagttccttg agctgtacca ggcaaaagtg gaatcgctga aagtcggcga 757621 cccaatggac cctgatacga ttatcgggcc attaatcaac agcagacaga cggacgggct 757681 gatgaagact gtagagcaag caattgaaga aggcgctgta ccagtgaagc ttggcggatt 757741 taacgggacg atcgtggaac cgacgatctt aaaagacgtc aaaccgttca tgagcattgc 757801 caaggaagag ctgttcggac cagtcgtctc ctttatgaag tttgattcag aagacgaagc 757861 ggtggatatc gcaaacgaaa ccccgtttgg cttgagcggt gccgtacata cgtcaaatct 757921 tgagcgcggc gtggcttttg cgaaacgcat tgaaacaggc atgattcacg tcaatgacac 757981 gaccatcaat gatgaaccga atgtagcctt cggcggtgaa aagcaatcag gcctcggccg 758041 tttaaacggt gagtggagcc tcgaagaatt tacaacgctg aaatggatct cggtccagca 758101 cgaaaaacgc agcttccctt attaatgaaa aggagtgaat ggaattgacc ataaatacgg 758161 aaaaagaaac cgcagatatt ctggacgcat ttatcaaagt agccccttat ttaaacagcc 758221 tggttcagga tgatattaca atcggcattt atgatacgga aaaactgctc gtgaatatac 758281 cggccaaaac cttttcgctg aacgtaaaag ccggcgatcc gctgcaggaa ggggatatca 758341 tcacagatgc catccgcagc aatcagaaga agacgagcat ggttccgaaa gaattgttcg 758401 gcttcccatt gatcgcgcgt gccatcccgc tgcacgacga gaatggaaga gtcattggag 758461 gcgtcggcct cggaacgagc cttgaggagt cgtcaaagct gcatgatgtc gcggaaagct 758521 tatcagctgt tgttgaacaa acagccgcgg ctatttccga catttctgaa tcaattaacg 758581 ggttttcaac tcaaatgtcg ggcatttcct ctcaggcgaa aaaagtaagc gaaagcgccg 758641 gtgaaatcgc cgatatttca gtaactgtta aaggcatctc ggaccaaagc aatctgctcg 758701 gcttgaacgc cgcgatcgaa gcggcaagag caggggagtc cggaaaagga ttctctgtcg 758761 tcgcagatga gatcagaaag ctagcgacgc attcaaaaga aaatgtcggc caaattgacc 758821 agattacgaa aaaaatccac agcctgctga aagggctgga ggaatccatt gagtcgatta 758881 accagcatac agacggacaa gccgctgctg ttgaacaaat ttccgccacg atgcaggaga 758941 tttcaggaag cgcgcagcat cttgcgaaaa tggccgaaaa agcgcttgag gaagagtaag 759001 agaccgggga caaacatccc cggtcttttt cttatcctgc atttccatga aattcgtctg 759061 acgttttact agttttattc cagcggctga tttaaaatgt acacatgaac ttacgtgagg 759121 attgatagga accatgagca tattaaaagc ggaaaatctt tataaaacat acggagataa 759181 aacattattt gaccatatct cctttcatat tgaagagaat gagagaatcg gattaatcgg 759241 gccgaacgga acaggaaaat caacgctgtt gaaagtgatt gccggcttgg aatctatcga 759301 agaaggagaa atcacgaaat ccggaagcgt gcaggtcgaa tttcttcatc aagacccgga 759361 gctgcctgcg gggcaaacag tgctggagca tatctattcc ggtgaatcgg ctgtgatgaa 759421 aaccttgcgt gaatatgaaa aagcgctgta tgaactgggg aaagatcccg aaaatgaaca 759481 gcgccagaaa cacctgctgg cagcacaagc gaaaatggac gcgaacaatg catgggatgc 759541 aaacaccttg gcaaaaaccg tattgtctaa gctgggcgtc aacgacgtaa caaaaccggt 759601 caatgagctc tcaggcggcc agaaaaaacg ggtggccatt gccaaaaact taattcagcc 759661 cgctgatttg ctcattttgg acgagccgac aaaccatttg gataatgaaa cgattgagtg 759721 gcttgaaggg tatttaagcc aatatcccgg cgccgtcatg ctggtgacgc acgatagata 759781 tttcttaaac cgtgtcacca accgcattta tgagcttgaa agaggcagcc tctacactta 759841 caaaggcaac tatgaagtgt ttttagaaaa acgcgcggaa cgggaagcgc aggctgagca 759901 aaaggaaacg aagcggcaaa acctgctgcg ccgcgaactg gcttggctca gacgaggagc 759961 gaaagcccgc tccacaaaac aaaaagcgag aattgaccgg gtagagacgc ttaaagagca 760021 gacaggccct cagtcatcag gttcactcga ttttgccatt ggctcgcacc gtctcggaaa 760081 acaggttatt gaagcggaga acgtcatgat cgcttatgac ggccgcatgc tcgtcgaccg 760141 ttttaatgaa cttgtcatac caggtgaacg gatcgggatc atcgggccga acggcatcgg 760201 gaaaacaacg ctgttaaatg cccttgccgg ccgtcatacg ccggacggag gcgatattac 760261 gatcggacag acggtcagaa tcggctacta tactcaggat catagtgaaa tgaacggtga 760321 gttaaaagtc attgactata taaaagaaac ggcggaggtc gtaaaaacgg cagatggcga 760381 tatgattaca gctgaacaaa tgctcgagcg tttcctcttc ccgcgttcga tgcagcagac 760441 gtatatccgc aagctgtccg gcggggaaaa acgccgttta tacttgcttc aggttctcat 760501 gcaggagccg aatgtcctgt ttctcgatga gccgacgaac gatttggata ctgaaacatt 760561 aagcgttctt gaggattata ttgaccagtt cccaggcgtc gtcatcaccg tatcccatga 760621 ccgctatttc cttgaccgcg tcgtcgaccg tttgattgta tttgaaggaa atggtgtcat 760681 ttcccgcttt caaggctcct atagcgacta tatggaggag tcaaaagcga aaaaagcggc 760741 cccaaaaccg gcagctgagg aaaaaacggc tgaagccgag ccgaagaaaa aacggaaaaa 760801 gctttcttac aaagaccagt tggaatggga cggcatcgaa gataaaattg cccagctgga 760861 agaaaagcat gaacagcttg aagctgacat cgccgcagca ggcagtgatt ttggcaaaat 760921 ccaagagctg atggccgagc aggcgaaaac ggcggaagag cttgaggctg cgatggaccg 760981 ctggacagaa ttgtccctca tgatcgaaga actggaaagc taaaaagcgt ggccgcagca 761041 ggccgcgctt tttttcacat aatggacaaa aacgaaccgg cctgcttatg ttaggataaa 761101 gttgtgtgtc agcggcacat ggaaaactaa cggagatgat gaagtatgac atgggcgatc 761161 gtgatgttaa ttctcatgag tctggtgaaa atcgtattaa cctgtcttcc tacaggcgtc 761221 atagaatggc tgctcggcaa atttgaagtg cacgccaagc tgagtgacga aaatgcgagt 761281 ctctctctag atggaaaacg cctcgagggt gcagagaagc agaaagtgat tgatcaattt 761341 aacgaagcta tcttcctgga aaaatattat atctatccag gtgatgaaga gcgttattta 761401 catccggaaa acggcggcac gcctctggtg atagatacaa aaaaaggaaa aaaagacgtg 761461 aagctgttcg tgtaccgcta cgacgaccat atcgacgtcg tgaaacagta caagaagaaa 761521 gtgatcgcgt atcgagtgct ttctgaaagc cttcaaaaag agtctctgtc agtggcggga 761581 agtttagctt aaacaggaaa gtgaaagacg ggtgctgtat gctgctcgtc ttttttattg 761641 ttttttaaaa cttaacgttt acgttaaggt tcaaaaggtg tataatggta acagaaacgg 761701 cgaaggggga tttaccttgg aatggatgaa gattgatcaa gtggccaaaa gaagcgggct 761761 gacaaagcgg accatccggt tttatgaaga aatcggcttg attccggcgc cgaaacggac 761821 agacggcggt gtaaggcttt attcagagga tgatatggag gagcttgaga aagtcatcag 761881 cacaaaagag gtgctcggtt tttcccttca ggagcttcag catttcatgg aaaccagccg 761941 ccagctagag ttaaacaaag aggggtattt gttgtcactg gatcctaagg aacggaaaga 762001 aaaactggag gaaattcagg aaaccctgaa tcaccagctg gatttgattg atgagaaaat 762061 ccgcacattc caaagcttta aagaacgcct gcagggcatg aaaggcaaag cggaacgcgc 762121 cattcaatca atcgaatgaa aagtttgtta aacgctattt ttgtagcgtt tcttttaatg 762181 gaataaagat ggaggttagg tcaaatggat aagacaacac aagtgaatca gaaaacgggt 762241 ttgctcagcc agccaaaagc ggtatgggct gtcgcgtttg cctgtgtgat ttcttttatg 762301 ggaatcgggc tggtcgatcc aattcttccg gccattgccg cacaattgca tgcttcacct 762361 agtgaagtat cactcttgtt tacaagttat ttgcttgtaa ccggatttat gatgtttttc 762421 tcaggagcca tttccagccg catcggcgcg aaatggacat taattctcgg acttattttt 762481 attattgtgt ttgcggggct tggcggcagc tcaagctcaa tcgctcagtt agtcggctat 762541 cgcggcggct ggggattagg gaatgctttg tttatttcaa cagcgcttgc ggtcatcgtt 762601 ggcgtgtcag tcggcggcag cgcccaagcg attattttgt atgaggccgc gctcggtctc 762661 gggatttctg tcgggccgct tgcaggcgga gagctcggaa gcatttcatg gcgcgcaccg 762721 ttttttggag tatctgtcct gatgtttatt gcgttaatcg cgatttcttt catgcttccg 762781 aagctgccga aaccggcgaa acgcgtcggt gtgtttgatg cgatgaaggc actcaaatat 762841 aaaggcctgc tgacaatggc ggtatcggca ttcctataca actttggatt ttttattttg 762901 ctagcttatt ctccgttcgt actggattta gatgaacacg gtcttggata tgtcttcttc 762961 ggctggggcc ttctgctggc gattacgtca gtctttacgg cgccgctcgt gcacaaagcg 763021 ctgggcacag tgcgttcgct agtcgttctc tttatcgcct ttgcggccat tctcgttatt 763081 atggggatct ggacagacca tcagactttg attattacat gtatcgttgt cgctggtgct 763141 gtcctcggta tggtgaatac gatcatgaca accgctgtga tgggttctgc gccggttgaa 763201 cgttcaatcg cgtcttcagc ctacagctca gtccgcttca tcggcggcgc gctcgccccg 763261 tggattgcag gaatgctgtc agaacacttt actgcaagca caccatatac agtaggcgga 763321 atcgtcgttt ttgtcggcat gcttgtcctt ctcatgggac gtaaacatct tgctggaatt 763381 aaggcggggc attaataacg aaagacactg cgcatatgca gtgtcttttt attcgttata 763441 atgcatcata atcgaattgg tgcaggaaag gacaaccttt atgacacaat tttactattt 763501 tccggctgaa aactcccttt agaaaccggt tttttcggtc agcaagaacg gcgttcgcgg 763561 aaagggcatc cgcttcggtc aggcattgat gcggctggga tttatcttgc agaagctgag 763621 aatgtgtccg ttcatttacg attgccattt cagtgatggt tcatgctgta gaggggacgt 763681 ttgccatgga taaggcaaaa cctgacgaat atgatcagaa atgtttagaa acgctctatc 763741 aatacataca cagcgtcatg aaaaacagct tttctcggtc gagtggttta ccgcttggga 763801 agatgaggag gattttgagc tgtctgccaa aagagagctg acacttgatg aattcacatc 763861 tccattgcag ctcattttaa aagacagaga gcttttgaga atcgttcaga aaaaatggca 763921 gtaaaaaacc cgccctttag caggcgggtt tttttataaa ttaaagcact ttcgtcgtcc 763981 aagactcgca gttccacgtt tctgtcgcaa tatccatata aaagtctggc tcgtgggaaa 764041 tgagcagaat ggagccttta tattctttca gggcgcgctt gagctcttcc ttggcatcgg 764101 catccaagtg gtttgtcggc tcatcgagca ccagcaggtt tgtttctgag ttgattagct 764161 tgcacaatct gactttcgct ttttcgcctc cgcttaatac ggagacgcgg ctttcgatat 764221 gctttgtcgt cagcccgcat tttgccagag cggcacggat ttcatactgc gtataagaag 764281 ggaattcgct ccatacttct tcgatgcacg tattgttgtt tgtttccttg acctcttgct 764341 cgaaatagcc ggtatagatg tgctcaccgc gttcaacaga gccttcgagc ggctggattt 764401 caccaagcaa acttttcagc aatgtcgttt ttccgatccc attcgcgccg taaagggcga 764461 ttttttggcc gcgctccatg cggaggttga gcggacggga cagcggggaa tcgtaaccga 764521 tcacgagatc cttcgtttca aaaatcagct tgcctgacgt tctcgccggc ttaaagtgga 764581 attccggctt tggcttttct gccgcaagct cgatcatatc catcttatcg agtttctttt 764641 ggcgggacat cgccatgttt ctcgtgctga cacgcgcttt gttgcgggcg acgaaatcct 764701 tcagctccgc gacttcctgc tgctgctttt tgtaggccgc ttcaagctgc tgttttttca 764761 cctcgtagac ttccataaac tgatggtagt cgccgacata acgtgtcagc tcttgatttt 764821 caacgtgata aatcaggttg atgacactat tcaagaacgg aatatcgtgg gaaatcagga 764881 tgaacgcgtt ctcgtattcc tgcaggtagc gtttcagcca ttcaatatgc tgttcatcaa 764941 gatagttggt cggctcatcg agaagcagaa tttccggctt ttcaaggaga agcttagcga 765001 gaaggacctt tgtgcgctgt ccgccgctca aatcggtgac atctcgctct aaaccgatat 765061 cgctcaaacc gagaccgcgg gcgatttctt ccaccttgga atcaatgaca taaaaatcat 765121 tgtttgtcag cgcgtcttga atgacgccga cttcttcaag cagcttctcg agctcgtcgg 765181 gatcagcctc gcccattttg ttgtaaatct cgttcatttc ctcttccatc gcaaataaat 765241 aatggaatgc gtctttcagg acgtcgcgaa tggattttcc tttttccagc acggtatgct 765301 gatcaaggta tccgacacgg acattttttg accattcgac ttttccctca tcaggttcaa 765361 gctttccggt aataatattc atgaaggttg attttccttc accgtttgcg ccgatcaagc 765421 cgacgtgctc gccttttaac aggcggaagg aaacgttatt aaaaatggcc cggtccccga 765481 aaccgtggct taaatccttt acagataaaa tactcatgtt tacacctcta tcgttatcaa 765541 acacgcacaa tcggcgtgta atattcaccc ttttgattat aaaggaggat tcggaatgtt 765601 gaaaggtata ggaaagaaaa agaaaaattg cgttccgggc gaggttttga gatactatgg 765661 aatagatttc aggaattgag gagaacaaaa tgacgcaaac ttggccattt ttacataatg 765721 cacaatcatt tatacaagag aattggaatg cttccggctt tcaaaagcca acccctgttc 765781 aggagcaggc agcccagctg atcatggacg gaaaggatgt cattgcagaa tcgccgacag 765841 gcacagggaa gacgctggcg tatgcgctgc cggtcttgga gcggatcaaa ccagagcaaa 765901 agcatccgca ggcggtgatt ttagcgcctt cccgtgagct ggtcatgcag atttttcagg 765961 tgattcagga ttggaaagcg ggctcagagc tgcgcgcggc ttccttaatc ggcggggcga 766021 atgtgaagaa acaggtcgaa aagctgaaga aacatccgca tatcatcgtc ggcacgccag 766081 gcagggtgtt tgaactgatt aaagcgaaga aactcaaaat gcatgaagtg aaaacgatcg 766141 tgcttgatga aacggatcag ctcgtcctgc cggagcatcg cgaaacgatg aagcaaatca 766201 ttaaaacaac attaagagac cgccagcttc tatgtttttc tgccacgctc aaaaaggaaa 766261 cagaggacgt gctccgcgaa ttggcgcaag agcctgaggt gttgaaggtg cagcgaagca 766321 aggcggaggc agggaaagtg aagcatcaat acctgatttg cgaccagcgc gacaaagtga 766381 agctgctgca aaagctgtca aggcttgaag gcatgcaggc actcgtattt gtgagagaca 766441 ttggcaacct gagtgtatat gcggaaaaac tggcatatca ccacgttgaa ctcggcgttt 766501 tgcacagtga agcgaaaaaa atggagcgag cgaaaatcat tgccacattc gaagacggag 766561 agtttcctct tttattggcg actgacattg ccgcacgcgg tttagatatt gaaaacctgc 766621 catacgtgat tcatgctgat attccagatg aagatggcta tgtccacaga tcaggacgaa 766681 caggccgggc cggaaaagaa ggcaacgtgc tgagccttgt gacaaaattg gaggaatcta 766741 agctgaaaaa aatggcgaag aagcttggtg ttgagctgag tgaagctgtg tatgcaggcg 766801 gaaaactgaa gacgaaataa aaagaagggc gaagagccct ttttttgttg taaaataata 766861 gaaaagattt tgcgcggagg tgggaaaatg gcttcaatag acaggtttca agtaatgcag 766921 gagccagagc tgaaaatcct tgaacactgg tttgagaatg aggataccag acggagaatg 766981 gatgggatgc tgctattaga tgagtggtat gcacgagtaa ataaagataa acacgatact 767041 gtcatcatgg cgtatgatgg acagctgccg gcagggatgg tcgttattga gttcggagag 767101 gagcggacat atattggatt gatcgtcaat cctttgtacc ggcttaaagg gtatggaaaa 767161 cagatactgc aaaagctgat gaccgaacct gattttacta gcgtgcgaga atgggtggca 767221 tgcattgaag aagacaatcg aatcagttta gcttgctttc aagcagcagg attcacttta 767281 gaagacacgg aacctgatga agatggtttt cttacgctga ttcttcgcaa ctgatctcat 767341 cgaaacacaa aaggagggca aaaagccctc ccgttttcat cttcattcag ctcggatcac 767401 tgaccttgat cagctgtttc cctttatttt ctcccttaaa taaaccgaga aacgcgtcag 767461 gaatgttttc gaagccttct gtgatggttt cctcgtaatg gagtttacca gccttcagcc 767521 attctgccag ctgttttgct ccctcagaaa aacgatcgga gtagtcgctt acgataaagc 767581 cttgcatcag cgacttcgtt ttaatgagtt ttgattggac acgagggccc atgtcatctg 767641 cttcgctttc tgcgttatag gaagaaatgg cgccgcacac cggaatgcgg gcaaattcat 767701 tgagcagatt catcaccgcg tctgaaatcg gtccgccgac attgtcaaaa tacacatcga 767761 caccgtcagg acaagcgttt tgaagcgctt tttggatatc atccgctgtt ttgtaattga 767821 tggcttcgtc aaactgaagc tcctgtttta aatagtcgat tttttcatca gagcccgcga 767881 tgccgacgac tcgcgcgcct ttgattttgg caatttgccc gactgttgaa ccgacggctc 767941 cggcagctcc tgagacaacc acggtttcgc cttccttcgg gcgtccgatg tccagcaatc 768001 cgaagtatgc tgttaagccg gtcattccca aaatgccgag ataggccgaa gcgggagcaa 768061 ggcttgtatc aatttttcgc aaggcagact cgctcacagc ggaaaattcc tgccagctga 768121 gatttccgat gacgatatcg ccttttttca gatgattccc gtctgacaca acttcagcga 768181 taacccctcc agaaagcgct ttatccaagg cgaacggctc aacatatgac ttcgtatcct 768241 gcatacggcc gcgcatataa gggtcaaccg atacataaag cgttttgaca agcacttccc 768301 cttgcttggg ttcaggaacc ggaatggttt caaagcgaaa gtcttcatga acaggaatac 768361 cttgtggacg tcttgctaat tgaatttgct gctgagatgc tgtcattttc atcctcctat 768421 cacttggttg acaccactgt aacatggaca ggagaggaaa tacaaaaggt aagctggcat 768481 acaaaaaagg ttatagatga gcttatgctt tctacaagct cttttgtttt aaaagttctc 768541 tttagtcatt tatcattatt agaaaacaga acagaaaaag agctcctgta cacctagcta 768601 agattggcta gtgtgtatgt cgattctttt tcatattctt gcaagcatct gcgaggggga 768661 gcttagtcgt tcacattttg ctttcgcatc aatctgcaat agcaaagtct atgcgatttt 768721 tttacatcag caaagatttg ttcaattttt tccttttatg ccgagttttt ctgaaacaga 768781 taattgatgg tactcaacca ttttcttttg gtcaataaag taatgtttac ttattaatta 768841 aacacgcgaa aaagcaaacg aaaacataat taaattttat atatttatta aaagcttata 768901 tgtttattta cctttttttt gaattgtaat tgagaaaatc catatattgc ggacactaat 768961 aaaagaatac ctgctgaaac ataaactaaa cgaactccaa ggaaatctga aatagcccct 769021 atagccagaa ttgaaaacat aaaaatgaac tgtactaaag aagaccttgc agacattata 769081 ttaattcgag tttgctcggt tgttatgttc tgaataagtg tttcttgtgt aagatctctt 769141 aatatataag ccggccccat aaagagaacc aaaattagag ctaagtatga attacttata 769201 aaaccatata ttaaagttaa acttccatat gagacagcgc caattaacat aaaattaatt 769261 aacttatttt gaaatctctc cgacagctta tatattataa atccccctat catcgaacct 769321 aaataatatg ctccattaat aaatccccac catgattctc ctttatgcaa gacttcgtta 769381 acgaaagcta aagagacaga tcctatccaa atcattcctg cccatgactc aattaaatcc 769441 ataataataa ttgttctaag tttcttttgg ctaaataaat accgccaacc acttactata 769501 ctcttattgg gagaattttt ttcacgtatg acagaattag cgtggccatg tggtagacaa 769561 aataaaagag aaagaagaga tgtaaacaac aaaaagatag taagtataat ggtatatccc 769621 tcacctaaaa atgcaattat gagaccacct aaagaccagc ctacaaattg aaaagtttgg 769681 tccactgtag ataataatcc atttgctttt actcttctat caggagagat tatttcccct 769741 ataattgcac tttttaaagg tgagaaccat ccattaaaaa aggaaataca gctaataata 769801 ataaagacta aaatgagagt ttgattagag taagttctta ataaagcata gaacaaacat 769861 attaataaca gcatttgtat caattgagaa ataattattg taagaggcag ttttaatcga 769921 attgttatta acggtaatat agcacttcca aaaatacgaa aaataatact tattaatgtc 769981 accatagagg cgatggttgt cgaattggtc attttaaaca aaaacgaaat cactaccata 770041 gtatatagag aaaaacctaa atttgtagtg gtctggctaa ataaaataga ataataacct 770101 ttactcatat gtatcctccc ttggaataat ttttctcggt aaagagctta aacatattta 770161 aacaccttaa aacaacaaaa gtaaagaaaa aatttccttg taaactattt acttttattc 770221 tatttattgt tattgtttat ttaagttctc tgactattct atcaatattc agggaaccac 770281 atatcttatt aaagggggga aaaccatgag aaaattaaga aaaaactgga gaaaatcgat 770341 tgttagcccg gttctttata ctaatgaaaa atggtaaaca cttagggaat agcatttaat 770401 gctattcctt atttcaacaa acaaatcggg aggttatcgt aatttgactc tattaatgca 770461 agatcataaa tcaatttaca ataaagatat agaaatatta attgaagttg aagaacttat 770521 tacttctgtt ccagaaaata aaaaaaatga ttttaagagt ttaatcgata atagaattat 770581 gactctacta aataaaattc aacaccctgt agcagcggaa aatgtgtttg ggatgtgtat 770641 tgcttatccg aatacttaca taaggtatag attaattgat ttcgttgaaa aatgggtacc 770701 ttatttctct gctgtagaaa ctataatcaa tctaacccag gatccggatg atttagtttc 770761 ttttaaagct atggatgtct gtgcaaatca taaaattgaa gaatctgtag catatttgtc 770821 ttcgattatt gatgatgtcc gggagagtat aagctaccct aaaaaacctg tgggattagg 770881 ggcccaaaaa gtattaagta cattattaga tatattcggt gttgaaaaac atgaagagct 770941 agtaatgcta aaaaattatt ttgatcaaaa tggtatactt cctaataact ttgactttga 771001 agaaaaaatt cctcaaagtc taatagagga attcgaaaaa acagaagaag atgggatgat 771061 tttaattccg ggtggctttt ttgaattcgg tttaaatgaa aatgaaattc ctgacaaaac 771121 atttaattgg aaagatgctg ttcctagaca aaaagtatgg ttacctccat tttttatcga 771181 taagtatcct gttacaaata aagattatga tatctttacc gagttcatag aggaaaatgg 771241 gcatatattc tgtcatccta atgaaccgca gaataaacaa catagaagaa atacatattg 771301 ggatgatagg tatttagata atcatcccgt tacaggtata gatttttatg atgcatttgc 771361 ttacgcaaga tataagggga aagaattgcc aaccgagttt caatgggaaa aagctgctcg 771421 aggcgaaaag ggtaatgtct ggccttgggg agataaattt gatcctgcaa aggttcaata 771481 tgctggaagt ctttataatg aacccattac ttctttaaag tcctggagag aaaatttatt 771541 aaaagctcat gctgataaag aattaaatca tttaacaagt gatatttttg aacaaaatgg 771601 tgaaagtccc tatggagtat gcggtatgat cggcggaaca tgggagtgga ctagaagtga 771661 gcttaaaaca aagagagctt tccaccctat ttttgagaat gtaccattta atagtgttaa 771721 ctcatttgcc gttcttaaag gaggatcatt cttctctcat ccaggcttaa tgttcccttc 771781 ttttagagca aaagatattc ctttctgtcg acacaatgaa atggggatta gatgcgtaaa 771841 gaatattcca gtatataaaa ttagagaatc aattaatggg ccaattacta ataaagcaat 771901 ttattaatca ttctaggtta gagacttgat aaaagtatac taacattgtg tagtaatgtt 771961 cagcttgtag aaaaaacaat gttttttcta caagatttta ttttaaatgc ttttcaaaat 772021 tatcagggat tgagaatcag aaaaagagcc attaagctcg atcttagcta ggtattacga 772081 tcttctgtat attattgtga gaaatataga agattcagtt agttagcatt tcgattttaa 772141 gctgagcctg caatagcaaa gcatctgttt tgattattct ttttctgata cataagctaa 772201 ttttgtcgct tttctttttt gtcttttcac gcatttcgag gatgacttac tataattctt 772261 tcagcttttc tatgtgttaa gattcgaata gatgaaataa ctttaacaag ttggtcaata 772321 agaacagatt taactttatg ttaaaagagt atctcgtata gaacataaga agaatgacga 772381 gttttttaag attatcatca attatgtgag aataaaatat tataagggaa aatgaaggct 772441 gtcacgtttc tcgacagccc tagggaattc ctctcctttt catttcgccc gtaatttcgg 772501 gcacagtccc gtcggcaggc acattggctt ctggtcgatc gggcttctca tgatgcagca 772561 ttccaagccg aagacttcac ggaaaaatgg ctgggtgaac acatcttccg gtgttccggc 772621 gttgtatatt tttccgtcca gcacactgat cagatagtca gcatattgag cggcttggtt 772681 taaatcatgg agcaccatga caacggtgcg gccatggtcg cggttcagct ttttcagcag 772741 ttcaagcact tcaatctgat gtgagatgtc taaatacgtg gtcggctcat caagcaaaag 772801 caaatcagtg ccttgcgcaa gtgccatgga aatccaggct ctttgtcttt ggccgcctga 772861 gagggcatca agtgtccgat ccttcagttc aatcatgccc gttgcttcca gcgcccactc 772921 taccatgtca tgatcctctt gggtatgctt ggataacagc tttttgtgag gatgtctgcc 772981 aaaatagcat aattcctcta ccgtcaatcc ttcaggagcc tgaggagatt gtggaagaat 773041 ggccagtttt tttgcgactt cttttgatgg ctggcggtgg atgtcttttc cttctagtag 773101 cactgtaccg ctttttgggg ccatcagcct ggcgagcgat ttgaggattg ttgatttacc 773161 gcagccatta gcgccgatga gcgcagtgat ttttccttct tctatcttta agtcgactcc 773221 gtcaataatc actgtactgt catatgaaag agtgagctgg tctgcagcca gttttcccat 773281 ggtatcctct ccctactgtt tcctcgcttc gaatttcaat aaatataaga aataaggcgc 773341 gccgatcacg gctgtcagta ttccggcagg tatttcaacc ggaggcatga tgccgcgccc 773401 taacgtatct gcaattaata atataatagc accaatcaat gccgatgcag gcagtaaata 773461 tttagctttt tctccggtaa gccgtctggc gatatgcgga gcaagcaagc cgataaaacc 773521 gattgagccg acgacggcta cacagcttcc cgccagcgcc accgcggtga aaatcaggat 773581 gaatctcagc cggtttgcgt tttctccgag accctgtgca agctcatccc cgagtgacat 773641 aagatccagc ttcggtatga gtatgcagac gatcggaaaa agaatcaaaa gccatggcgc 773701 aagcagcttg acttcttccc agtttcttcc ccagaggctt cctgtcagcc aaatgagtgc 773761 agcattcacg tcgcctggaa acttgaccat catatattgc attccggcgt ggcagaccgc 773821 gcctaaagca atgcctgata aagccagtga agagggctga atgctctttt ttcgggctat 773881 cattaataat agtacagcaa taatggcggc tccggcaaat gcggagaacg gaagcacgta 773941 taccggcgac tcaggaaaga tgagaatcac agccatcgcc gcaagtccgg agccttttga 774001 aatgccgaca acgtccgggg aagcgagcgg atttcggatc acaccctgta aaatcgctcc 774061 ggcagcggca agtccagcac ctgccaaaat cgctaatata atgcggggaa ggcgatattg 774121 ctggatgata aattcaaagg aatgatccag tcccagcaga ttcgtcacta ccgcatcagg 774181 tgaaatgtat aatgcaccga ttccaatgct gatgacggac agaacgatta aaatcacggc 774241 caatatgagt atcgccagta aggggcgttt ttgttttctg gttgttttct tcatttcagg 774301 tttcgccctt tccttgccaa atataagaaa aacggcgttc cgataatcgc ggtgacaatg 774361 ccgaccggtg attcataagg aaatgcaatc catctggcca gaacatctgc gtacaccagc 774421 aaaatggcac cgaacagtgc cgaaaacgga agcacgtatt gataatgttc tccgatcagc 774481 ttgcggacaa tatgcgggac gagcagcccg acaaagccaa tcggcccggc gacggctacg 774541 gaagcgccgg aaagaattaa aataatcaaa ctgatcagaa tcctgatgcc gttcatattt 774601 tgtccaagcc cttttgctgt ttcgtctccg agaccgagaa cagaaacaga accggaaaat 774661 acgagggcaa gcccgatgcc aatgacagaa aaaggagcga tggttatgac gtcctgccag 774721 ttgctgccgt cgattgcgcc tgtcatccag tacagaacat cctcacctga ctcatttaaa 774781 ataatgatgg cctgtgtcat agaggagagg aacaagtgca cggccattcc tgacagcgcc 774841 agcttgacag gcgtcattcc gccggatgag gcaatcatat acacaatcgc gccgcctgct 774901 gccgcacccg caaaagcgaa tataacagat gaatagggcg atgccggcag aatgacgaga 774961 gaagcaacaa caaaaagcga tgcacccgca ttcacaccga aaatttgggg tgaagccaga 775021 ggatttctgg tcatagcctg catcagcgcc cctgctacag ctaggctggc gccgacaaaa 775081 acgccgatta atgtgcgggg aaggcgaaga gtagagatga tgagctgttc ctttgaaccg 775141 tcccatacaa aaagatattt caatgaatct atgatgctga tgtctgaggc tcctactgaa 775201 agattcagcc caagcccaaa tataaaaata atcagtgcaa tgataaacat catcagtctt 775261 gatgatgagc gccgtttggc tgaatgatac aacagtctca cttccttact gcgtctggtt 775321 gcaaaaacga agaagcaagg attcccctcg cttctcattt gtcctattta ttatacactt 775381 ttttaagcac atctttggcg cttgtttcac tagacttgat gcctctgaat cttgtccaag 775441 tgtcacggtc cgcatcatag acttgtccat ttttcaccgc tttgagattt ttccagagcg 775501 ggttcgtttt ccactcatct acaatggttt tgccttcgtt ggctgagatg aacaaaatat 775561 caggatcgat tttgctcaat tgctcaaggc tgacctcttg ataggcgtta tctgacttca 775621 cagcgtgtgt aaagcctagc attttaaaga tttctccgtc ataggatgat gatgtatgaa 775681 gctggaagga atccgctctt gcaacgccga gaacgatgtt gcggttttca tctttcggaa 775741 gttcggcttt tagatcgttg atgacttttt tgtgctcggc aagcttttct tttccttcat 775801 cttctttatt taatgcttta gcaatggtcg taaagctgtc gatcgtttcg tcatatgtcg 775861 cttcacggct ttttaattca atcgtcgggg cgattttttt cagctgttta taaatgtttt 775921 tatggcgctc agcgtcagcg atgattaaat caggcttcaa ggaactgatg acctcaagat 775981 tgggttcgct gcgtgtgcct acagatgtgt aatcaatgga gctgccgaca agctttttaa 776041 tcatatcttt tttgttgtca tctgcgatgc ccaccggcgt aatgccgaga ttgtgaacgg 776101 catccaagaa tgaaagctca agcacaacca cccgcttagg tgtgccgctt actgtcgttt 776161 ttccttcttc gtcatggatc actctggaat ccttagactc gcttttgccg cttccgttgt 776221 tattctggct tgatgaacag ccggatacaa tgaggcaggc gagcaataaa acactcatga 776281 tggcaatcaa cttgttagaa taggtgcgca tgtcattctt ccttttttca gatttagtaa 776341 tgagaatcat tatcacatgt aacactataa tagcatggct tatcatgtca atattttttt 776401 agtaaagaaa gctgcgtttt tactgctttc tcatgaaagc atcatcagac acaaataagt 776461 ggtatgcagc gttaccgtgt cttcgagaca aaaacgcatg ggcgttggct ttagaggttt 776521 cgaacatatc agcagtgaca taaggaagga gagtgctgag ataaccggac aatttctttt 776581 ctatttcatc tgttagtgca aattcaatgt cgccgatatt catgataatc gagaaaacaa 776641 agtcgatatc gatatgaaaa tgttcctcgg caaaaaccgc aagctcgtga attcctggtg 776701 aacatccggc acgcttatgg aaaatctgtt tgactaaatc actcacaatc caagcattgt 776761 attgctgttc tggtgaaaag tattgcatta gacatacctc ctgctcgtac ggataaaggc 776821 agcgtttcat ggtcgtgtgc tccgtgcagc ggcttctcct taattttgat ttttctgaaa 776881 ataggtcccg ttcctatcac tttaccatgg acggaaaaca aatagctact accattcctc 776941 ctgtttttct cttcaatgtt ctggaatctg tttcaggtac agacgatcgg gtatgaaaga 777001 aatatagaaa acatgaagga ggaatatcga catgaaacca gttgtaaaag agtatacaaa 777061 tgacgaacag ctcatgaaag atgtagagga attgcagaaa atgggtgttg cgaaagagga 777121 tgtatacgtc ttagctcacg acgatgacag aacggaacgc ctggctgaca acacgaacgc 777181 caacacgatc ggagccaaag aaacaggttt caagcacgcg gtgggaaata tcttcaataa 777241 aaaaggagac gagctccgca ataaaattca cgaaatcggt ttttctgaag atgaagccgc 777301 tcaatttgaa aaacgcttag atgaaggaaa agtgcttctc tttgtgacag ataacgaaaa 777361 agtgaaagct tgggcataaa gcaaggaaaa aaccaaaagg ccaatgtcgg ccttttggtt 777421 tttttgcggt ctttgcggtg ggattttgca gaatgccgca ataggatagc ggaacatttt 777481 cggttctgaa tgtccctcaa tttgctatta tatttttgtg ataaattgga ataaaatctc 777541 acaaaataga aaatgggggt acatagtgga tgaaaaaagt gatgttagct acggctttgt 777601 ttttaggatt gactccagct ggcgcgaacg cagctgattt aggccaccag acgttgggat 777661 ccaatgatgg ctggggcgcg tactcgaccg gcacgacagg cggatcaaaa gcatcctcct 777721 caaatgtgta taccgtcagc aacagaaacc agcttgtctc ggcattaggg aaggaaacga 777781 acacaacgcc aaaaatcatt tatatcaagg gaacgattga catgaacgtg gatgacaatc 777841 tgaagccgct tggcctaaat gactataaag atccggagta tgatttggac aaatatttga 777901 aagcctatga tcctagcaca tggggcaaaa aagagccgtc gggaacacaa gaagaagcga 777961 gagcacgctc tcagaaaaac caaaaagcac gggtcatggt ggatatccct gcaaacacga 778021 cgatcgtcgg ttcagggact aacgctaaag tcgtgggagg aaacttccaa atcaagagtg 778081 ataacgtcat tattcgcaac attgaattcc aggatgccta tgactatttt ccgcaatggg 778141 atccgactga cggaagctca gggaactgga actcacaata cgacaacatc acgataaacg 778201 gcggcacaca catctggatt gatcactgta catttaatga cggttcgcgt ccggacagca 778261 catcaccgaa atattatgga agaaaatatc agcaccatga cggccaaacg gatgcttcca 778321 acggtgctaa ctatatcacg atgtcctaca actattatca cgatcatgat aaaagctcca 778381 ttttcggatc aagtgacagc aaaacctccg atgacggcaa attaaaaatt acgctgcatc 778441 ataaccgcta taaaaatatt gtccagcgcg cgccgagagt ccgcttcggg caagtgcacg 778501 tatacaacaa ctattatgaa ggaagcacaa gctcttcaag ttatcctttt agctatgcat 778561 ggggaatcgg aaagtcatct aaaatctatg cccaaaacaa tgtcattgac gtaccgggac 778621 tgtcagctgc taaaacgatc agcgtattca gcgggggaac ggctttatat gactccggca 778681 cgttgctgaa cggcacacag atcaacgcat cggctgcaaa cgggctgagc tcttctgtcg 778741 gctggacgcc gtctctgcat ggatcgattg atgcttctgc taatgtgaaa tcaaatgtta 778801 taaatcaagc gggtgcgggt aaattaaatt aagaaagtga aaaacacaaa gggtgctaac 778861 ctttgtgttt tttaattaat taaaatgttt attaacttag ttaaggagta gaatggaaaa 778921 ggggatcgga aaacaagtat ataggaggag acctatttat ggcttcagaa aaagacgcag 778981 gaaaacagtc agcagtaaag cttgttccat tgcttattac tgtcgctgtg ggactaatca 779041 tctggtttat tcccgctccg tccggacttg aacctaaagc ttggcatttg tttgcgattt 779101 ttgtcgcaac aattatcggc tttatctcca agcccttgcc aatgggtgca attgcaattt 779161 ttgcattggc ggttactgca ctaactggaa cactatcaat tgaggataca ttaagcggat 779221 tcgggaataa gaccatttgg cttatcgtta tcgcattctt tatttcccgg ggatttatca 779281 aaaccggtct cggtgcgaga atttcgtatg tattcgttca gaaattcgga aaaaaaaccc 779341 ttggactttc ttattcactg ctattcagtg atttaatact ttcacctgct attccaagta 779401 atacggcgcg tgcaggaggc attatatttc ctattatcag atcattatcc gaaacattcg 779461 gatcaagccc ggcaaatgga acagagagaa aaatcggtgc attcttatta aaaaccggtt 779521 ttcaggggaa tctgatcaca tctgctatgt tcctgacagc gatggcggcg aacccgctga 779581 ttgccaagct ggcccatgat gtcgcagggg tggacttaac atggacaagc tgggcaattg 779641 ccgcgattgt accgggactt gtaagcttaa tcatcacgcc gcttgtgatt tacaaactgt 779701 atccgccgga aatcaaagaa acaccggatg cggcgaaaat cgcaacagaa aaactgaaag 779761 aaatgggacc gttcaaaaaa tcggagcttt ccatggttat cgtgtttctt ttggtgcttg 779821 tgctgtggat ttttggcggc agcttcaaca tcgacgctac cacaaccgca ttgatcggtt 779881 tggccgttct cttattatca caagttctga cttgggatga tatcaagaaa gaacagggcg 779941 cttgggatac gctcacttgg tttgcggcgc ttgtcatgct cgccaacttc ttgaatgaat 780001 taggcatggt gtcttggttc agtaatgcca tgaaatcatc cgtatcaggg ttctcttgga 780061 ttgtggcatt catcatttta attgttgtgt attattactc tcactatttc tttgcaagtg 780121 cgacagccca catcagtgcg atgtattcag catttttggc tgtcgtcgtg gcagcgggcg 780181 caccgccgct tttagcagcg ctgagcctcg cgttcatcag caacctgttc gggtcaacga 780241 ctcactacgg ttctggagcg gctccggtct tcttcggagc aggctacatc ccgcaaggca 780301 aatggtggtc catcggattt atcctgtcga ttgttcatat catcgtatgg cttgtgatcg 780361 gcggattatg gtggaaagta ctaggaatat ggtagaaaga aaaaggcaga cgcggtctgc 780421 ctttttttat tttcactcct tcgtaagaaa atggattttg aaaaatgaga aaattccctg 780481 tgaaaaatgg tatgatctag gtagaaagga cggctggtgc tgtggtgaaa aagcggttcc 780541 atttttccct gcaaacaaaa ataatggggc tgattgcggc tctgctggtc tttgtcattg 780601 gtgtgctgac cattacgtta gccgttcagc atacacaggg agaacggaga caggcagagc 780661 agctggcggt tcaaacggcg agaaccattt cctatatgcc gccggttaaa gagctcattg 780721 agagaaaaga cggacatgcg gctcagacgc aagaggtcat tgaacaaatg aaagaacaga 780781 ctggtgcgtt tgccatttat gttttgaacg aaaaaggaga cattcgcagc gcctctggaa 780841 aaagcggatt aaagaaactg gagcgcagca gagaaatttt gtttggcggt tcgcatgttt 780901 ctgaaacaaa agcggatgga cgaagagtga tcagagggag cgcgccgatt ataaaagaac 780961 agaagggata cagccaagtg atcggcagcg tgtctgttga ttttctgcaa acggagacag 781021 agcaaagcat caaaaagcat ttgagaaatt tgagtgtgat tgctgtgctt gtactgctgc 781081 tcggatttat tggcgccgcc gtgctggcga aaagcatcag aaaggatacg ctcgggcttg 781141 aaccgcatga gatcgcggct ctatatcgtg agaggaacgc aatgcttttc gcgattcgag 781201 aagggattat tgccaccaat cgtgaaggcg tcgtcaccat gatgaacgta tcggcggccg 781261 agatgctgaa gctgcccgag cctgtgatcc atcttcctat agatgacgtc atgccgggag 781321 cagggctgat gtctgtgctt gaaaaaggag aaatgctgcc gaaccaggaa gtaagcgtca 781381 acgatcaagt gtttattatc aatacgaaag tgatgaatca aggcgggcag gcgtatggga 781441 ttgtcgtcag cttcagggag aaaacagagc tgaagaagct gatcgacaca ttgacagagg 781501 ttcgcaaata ttcagaggat ctcagggcgc agactcatga attttcaaat aagctttatg 781561 cgattttagg gctgcttgag cttggggagt atgatgaagc cattgatctg attaaagagg 781621 aatatgcgat acaaaatgaa cagcatgatc ttttattcca taacatccat tcgcagcagg 781681 tgcaggccat tttgttaggg aaaataagca aggcatcgga aaagaaggtc aagctggtga 781741 ttgatgagaa cagctcactc gcgcctcttc ctgcgcatat cggcttgtcc catcttatta 781801 cgattattgg caatttaatt gataacgctt tcgaagctgt agcggagcaa agcgtgaagg 781861 aagttttgtt ttttatcacg gatatgggcc atgacattgt cattgaagta tcagacacag 781921 ggcccggtgt gccgccagag aaaatagaag ctgtgtttga gagaggctat tcttcaaagg 781981 ggatgaggag aggctacggt ctggccaatg tgaaagactc agtgcgtgaa ctgggcggct 782041 ggatcgaact ggcgaatcaa aaaactggcg gggcggtatt cactgtattt ataccgaagg 782101 agaaacaaag ggggaatcca tttgattcac atcgcgattg cggaggatga ttttcgagtt 782161 gcgcaaatcc atgagagatt gattaaacag cttgatggat tcaagattat cggcaaggcg 782221 gctaacgcaa aagagacatt ggcgcttttg aaggaacaca aggctgattt gcttctgctg 782281 gatatttata tgccggacga gcttgggacc gcgttgattc ctgatatacg aagccgattt 782341 cctgaagtgg acattatgat tatcacagcg gcaacagaaa cccgtcattt gcaggaagcg 782401 ctaagggcgg gaattgccca ctatttgatc aaacccgtaa cagctgacaa gttcaggcag 782461 gtgctgcttc agtataaaga aaaaaggaag ctgctcatgt ctcagccgga ggtcagccaa 782521 tccatgatcg accatatttt tgggaacggt gtgaagacag ctttgccggc agaggatttg 782581 ccgactggca ttaattcgat tacactgcga aaaattaagg aagcgcttca gactgcgtca 782641 gaaggattga cagcggagga acttggggaa aaaatggggg cgtcacgaac aactgcccgc 782701 cgttatgccg agtaccttgt gtcaaaggaa gaagcaagag ccgagcttga atacgggatt 782761 atcggcaggc cggagagaaa atattatttg gcggcggatt agatatgaaa aaatctataa 782821 tcctattgaa tattctattg atctttatgc agggtgatat caggcaggcg gctgcgccgc 782881 gcctgccgga cgggccgata gaaattgtcg tccctgccga accttctggc ggctgggatg 782941 tcacagcgca ggcgatccaa tcagttttga ggcagaagca gatcgtgaag gatgatgttc 783001 atatcgtcta taaatccggc ggcgggggag agaaaggctg gaaatatgtc aacaaaagca 783061 gcaaacaaac catcagcatg acgtccagcc taatattgag caatgatctt ctcgggcaaa 783121 gcaaattaaa aatgtccgat tttacgccgc tcgccattct ctccaaggaa tggcagacgg 783181 ttgcattgcc aaaaggatca gcgttaacaa atggcaagga tgtgctgaat gagatcaaca 783241 tgcatcccgg caaggtgaga atcggctttg ccccggggtt tggcaatgat gatcagctct 783301 cgttcgtcag agcggcagat atgtacggca ttgacccgtt tgacattcaa ttctcacagt 783361 atgacagcag cgaacagctc attcaggcgc tgatcagaca tgagatagaa gcggcttcca 783421 tgacactttc tgaagcgaaa ccatatgaac gaaacggcga tatcacgtta gccgctgtaa 783481 cgtctgataa aagacttccc ggttttccaa atgtaccgac gtggaaggag cagggaatcc 783541 cgtttgtttt ttctcattgg agagggattt tgggcccgaa aaatatgtct gaggaagaga 783601 tttcttactg ggatcaagcg ctaaagaagg tcacctcctc acctgaatgg aagcggaaaa 783661 taaacgaaca ggactgggaa agcttttatt taaacagcag ggaaacgaaa cggtttttag 783721 aagagcaatc tgctttttat caaagcatca tgacaggaaa ttaaaatccc gacatcccgg 783781 gatttttttc atgccgaaaa ttgatcaaaa agaacaaaac ggttttaaaa aattaaaaat 783841 acaaaaaaac caaattattt acttgcggtt ggttttccca tacgatggca aaaaggcaag 783901 acaaaaaggg gagtaaggga gaaaaaaatg taagcggatt catttaaggg ggaatggatg 783961 tgttagcaat cttaggcttt ctcatgatgc ttgtgtttat ggcattgatc atgacaaaac 784021 ggctttctgt tttaacagca ttagttttga cgccgattgt gtttgcgctt atcgccggat 784081 ttggatttac tgaagttggg gacatgatga tttcggggat tcagcaagtc gcgccgactg 784141 cggtcatgat tatgtttgcg atcttatatt ttggaattat gattgataca ggcctgtttg 784201 atccaatggt tggcaaaatt ttaagcatgg tcaaaggaga ccctttaaaa attgttgtcg 784261 ggacagcggt tcttacaatg ctcgtcgcct tggacggaga tggctcgaca acgtacatga 784321 ttacgacaag cgccatgctt ccgctctatt tgctgctagg catccggcca attatcttgg 784381 caggaatcgc gggagtcggc atgggaatca tgaacacgat tccatgggga ggtgcgacgc 784441 cgagggcggc gagtgcgctg ggggttgatc cagctgagct tacagggccg atgattcctg 784501 tcattgcaag cgggatgctt tgtatggtgg cagttgcgta tgtgcttgga aaagcggaac 784561 gaaagcgcct tggtgtgatt gaactgaaac agccagccaa tgccaatgaa ccggctgctg 784621 cggttgaaga tgagtggaag cggccgaagc tttggtggtt caatttattg ttaacgcttt 784681 ctttaatagg atgtttagta tcgggtaaag tcagtttaac cgtactgttt gtcattgcgt 784741 tttgtattgc gctgattgtg aattatccca atctcgagca tcagagacag cgcatcgcgg 784801 cgcattccag caacgtgctg gctatcggtt caatgatttt tgctgcgggg gtgttcacgg 784861 ggattttgac aggcacgaaa atggttgatg aaatggcgat ctcgctcgtg tccatgatac 784921 cggaacaaat gggcggattg atcccggcga ttgttgcctt aacaagcggc attttcacat 784981 ttttgatgcc gaatgacgcg tatttctacg gggtgctgcc gattttatca gaaacagctg 785041 tcgcatacgg tgtggataaa gtggaaattg ccagagcctc tattatcggc cagccgattc 785101 atatgctgag tccgcttgtg ccatccactc atttgcttgt cggactcgtc ggagtttcta 785161 ttgatgacca tcaaaaattc gcattgaaat gggcggttct cgcagtgatc gtcatgacgg 785221 ctatcgctct attgatcggt gcgatctcta tttccgtatg ataattcagg cgtaatgaca 785281 cacactaacg gcatacaaca ttccggaggt gtcattatga gtgatcctta tatgccgctg 785341 acttcagtca gaagcggagc ggggttcgaa gcggcaaaag gggtgcacgg cctgactgtg 785401 caaattgcga atgtctattt tattcagctg ccttctgaac ctcactcatt tgttttaatt 785461 gatgccggca tgccccaatc agccggcgtg attgtcaatg aagccaaaca aagattcggt 785521 gaagggtttc agctgaaggc gattatcctc acacacgggc actttgacca tattggggca 785581 atcgaagaga tccttgagca ttgggatgtg cctgtttata tccattctcg ggaaatgcct 785641 tatgtaacag gtaaagagga ttatcctccg gctcgtcctg acagcaagag cgggctggtc 785701 gctaagctgt cgccgctgtt tccgcggcac tctatcgata tttcctcaca tgtccaggca 785761 ctgccggaag acggttcagt tccttttctt gacgagtgga tgtggatcgc gacaccagga 785821 cacacgccgg gccatatttc gttattccgc gatgacggcc gcgtgcttgt ggcaggtgat 785881 gctgttatta cagtggaaca ggagaaaatg gctgacgtct tgatacaaaa acaggagctt 785941 cacgggccgc cggcttattt cacgcctgac acagagacgg ccgctgagtc cattctaaag 786001 ctggccggtc ttgaaccgga agcgttattg accgggcacg gcataccgat gaccggcaaa 786061 aactttcgaa gtgacttaac tgaattggca aatcggttat cgtctatttg acacccgcac 786121 cacgcgggtg ttttttattg ttttccagga agttgcagaa aaatcatttg tcttgccgct 786181 taaaaacgat acaatgaaaa gcatgaagtg atgtgaaggg gagagtttgt tggaagaaaa 786241 agaaatactc tggaacgaag cgaaagcgtt tattgccgca tgctatcagg aattgggaaa 786301 ggaggaggaa gtgaaagacc gtctcgcgga cattaaaagt gaaattgacc tgaccggaag 786361 ctatgtacat acgaaggaag agctggagca cggagcgaaa atggcttgga gaaacagcaa 786421 ccgctgcatc ggcagattgt tctggaattc gctgaatgtt atcgacagac gagacgtccg 786481 gacgaaggag gaagtgcgtg atgccctctt tcaccatatt gaaaccgcca ccaataacgg 786541 gaaaatcaga ccgaccatta cgattttccc tccggaagag aagggtgaaa agcaagtcga 786601 gatctggaat catcagctga tccggtacgc tggatatgag tcagacggag aaagaatcgg 786661 cgacccggct tcctgttccc tgacagcagc ctgcgaagag ctcggctggc gcggagagcg 786721 aacggatttt gacctgctgc cgctcatttt tcgcatgaaa ggggacgagc agcctgtctg 786781 gtatgagctg ccgcgttcac ttgtgattga ggttccaatc acacatccgg acatcgaggc 786841 gttttctgat ttggagctga agtggtacgg cgtgcctatt atttctgata tgaagcttga 786901 ggtcgggggc attcattata atgccgcgcc atttaacggc tggtatatgg gcacggagat 786961 cggagcgaga aacctcgcag atgaaaagcg gtacgacaag ctcaaaaaag tagcgtccgt 787021 gatcggcatc gccgctgatt acaatacgga tttatggaag gatcaagcgc tagttgaatt 787081 gaataaagct gtgctgcact cgtataaaaa gcagggtgtc agcatcgttg accatcatac 787141 agcggcaagc cagtttaaac ggtttgaaga acaggaggaa gaagcgggca gaaagctgac 787201 gggggactgg acgtggctga ttccgccaat ttcacccgct gccactcata tcttccaccg 787261 ctcctatgat aactcaatcg ttaagccgaa ctatttttat caagataagc cttatgagta 787321 aacaatagaa aatcgatgat ggccttcaag gctgcgggat tcagtcacag agatgtcggt 787381 aacctttgag aaagggcttc cgttctttac agcctcaaca aacgattgca gggcgttttc 787441 cggaccctct gccaaaatct cgacacgccc gtcatcacgg tttttgaccc agccggccag 787501 ttttcgctta tcagcttcca tttgaacaaa atagcgaaag cccacacctt gaacccggcc 787561 gtctacaatg attcggtatt gaagcatgta aaaaccacct tttcttttta tgataatcaa 787621 tcattttaca acctgtaaag gggatgtgtt tgtatgaaac aagagcgcta ttcagttctt 787681 tctcttaatc tgggaaaacc gcagacgctt gaatatgacg gaaagaaaat cgaaaccggc 787741 atcatgaagc ggccggctaa atcagccgtc atgctgtatc gggagaattt tgaaggagac 787801 ggacaggcgg acctcgtcaa ccacggcgga cctgataagg ctgtctgtgt ctacccggcg 787861 gagcattatc cgttttggga agagttcctc tcaagaccgc tgtcaaatgc cgcatttgga 787921 gaaaatctga cggtcgcggg cctgactgag gagaatgttt gcatcgggga tgtgttcaga 787981 cttgatgaag ctgttgttca ggtcagccag ccgcgccagc cgtgtgtaaa gctggcgaaa 788041 aagtttggtg taaaagaaat ggtgctgaag gtccagcaaa ccggctatac agggttttat 788101 tttcgcgtgc tggaggaggg cagggtgtct cccggcgcga accttgaatt gctgtccaga 788161 ggagagaaag gcatatccgt ccagttcgcg aaccgcatca actaccatga tgcaaaaaat 788221 ctcaccgcca ttgaacggat tttaagtgag gctgcactat cggaaagctg gagagcgtcc 788281 tttatgaaaa aaaaggacag gctgctgccg gttgaataga aaaaagccgc gcatatcaac 788341 gtgcgcggct ttgccatatt taagattgtt ttttctttga ttcaagcagg ttggcaagaa 788401 aataggtttt atagctttga agctttcttc cttcatggtg cgtgatcccc tgctttttta 788461 gttctgccac ataccagcct ttactgccgt aatgcatgtc agaaaactcc tttccctatc 788521 tgatttcgaa acgattggca ttgtaacatc tataaaaaga tgctgaaaag agatgcgggg 788581 aaaactgagc ctttcgcact agatgtacga atgttcttct gaatgtatat gcggagcaaa 788641 agccgaatat gatttaatgg ccggttagtt tgatcatgac aacgccaaat gtcataatgg 788701 cgaaaacaat gccgatatat gtgagcatcc cgtttttttt cttaacgccg taaacggtca 788761 taatgatgcc ttcaatgaaa aaaatgatgc cgaaaataat aaaccacatg cagataaagg 788821 ctcctttcac agacataata gtagtgtagc atatctgaaa gagccgggct gtgacaatat 788881 caagaaagcc gggcgcatat cgcccggctc atgttttatt gtttatcaac caatttgacc 788941 agaagctgtg ccaaatgttc tttctcatct tcgtctgcaa cgctccaaag ctcttgcagc 789001 agcatttctt caccgttttg cggctcttca tgctttgcga ggtagtctcc caggatcgca 789061 gcgcttttta caagcttgcc gtcatccaat cccagctttt tgcctcggtt gacttgtttt 789121 ttcaggtagc ctttaaattc ctcaaagtct tttaaaatgt cttcttttat tgtgccatgc 789181 atcgcgttca tttcgttttc aatttggatt ttttcttgat ctctgttcat tgcaagacct 789241 cctcgtacag aataatgatg ctttacctgc aattggagga ggttaaacct gccggaagcc 789301 cggaatgtgt tttacagttt cgtcaggata atcggttcat cttttgtgat gacgatcgtg 789361 tgttcaactt gggcaaccat gcttttatcc ggcgtcttga acgtccagcc gtctccagct 789421 tcaacaatcg tttctgcttt cgttgaaata aacggttcaa gcgcgatgac tgtgccattt 789481 ttgaacagcg cattatcaaa cggatcataa tagttcatga tgtggttcgg cgcttcatgc 789541 aggcttcggc cgattccgtg gccggtcagg gttttgatga cggtaaagcc ttgagagcgt 789601 gcttcatgat aaacggctct tccgatctgg ttttggcgct tgcccgcttt tgcctgctga 789661 agcccctttt gaaaagcgtt ttccgcgcat tggcaaagct tatgaaggcg ttcttctcct 789721 tcaccgagca caaatgagat gcctgtgtcg gaatagaagc cgccaaattc agcggagatg 789781 tcgatgttga caaggtcccc tgcttttaaa attttggatg tgcttggtat gccgtgagcc 789841 acttcatcat ttacgctgat acatgtcaca cctggaaaat cgtattcctt ctcaggagct 789901 gaaacggcgc cgtgctcatc aagcacagct tttccgataa ggtcaaggtc ttttgtgctc 789961 atgccgggct ctgccttccg cttcatttct tcacgcgcaa gcgcgacgat tcttccgatt 790021 tttttcaggc cttctaattc ttgatcgttt gttacaatca tctgtcattc ccgctttctt 790081 tttaaataat ctagattaag cttaccacaa ctgtcttaaa aataggaaac acacggacct 790141 gggaaaaaag aaataccccc gggaaaattg gtatagatca ctagatatct tatatggtat 790201 atttgaaaaa aaagggtatg agggggatgg gtatgctttc atttttacaa aaactcggga 790261 agtcatttat gctcccgatt gcggttctgc ctgcggttgg aattatcctt gcgcttggca 790321 gagaggatgt atttaatatc ccgtttgtct atcaggcggg gacggcggtt tttgatcatc 790381 tgccgcttat ttttgcgatc ggtattgcca tcggcatttc aaaagacagc aatggggcag 790441 cgggtttatc aggggcgata tcgtatctga tgcttgacgc ggcaacaaag acaattgata 790501 aaacaaataa catggcggtg tttgggggaa ttattgccgg tttaattgcc ggttacacct 790561 ataaccgctt caaggatacc aagctgcctg aatatctcgg gttcttcagt ggcagacggc 790621 ttgtgccgat tttaacagcc attattacga tcattttagc gggcatattc ggagtggtct 790681 ggccgccgat tcaatcgtgt atcaactcgt ttggagagtg gatgctcggg ctcggcggca 790741 tcggggcagg catattcggc ctattcaaca ggctgttaat tccgcttggc cttcaccatg 790801 tgctgaacaa tattttctgg ttccaattcg gagaatataa cggagtgaca ggggatttgg 790861 cgcgcttttt cgcgaaagat ccgactgcgg gcacatatat gaccggattt ttcccaatca 790921 tgatgttcgg tcttccggcg gcgtgtctgg ctatggttgt gactgcgaag ccgtctaaac 790981 ggaaagcgac ggctggaatg atgattggat ttgctttaac ggcgtttatc acagggatta 791041 cggagccgat tgagtttgca tttatgtttt tatctccgct tttatacgct gttcacgcgg 791101 tcttaaccgg gttatcttta tttatcgtca actggctcgg catccgctca ggcttctctt 791161 tttcagccgg agctatcgat tatgtgctca gctatggaat cgcggaaaaa ccgctgcttc 791221 tgcttttggt aggtatatgc tatgcggcag tatactttat cgtgttttat gtactgatta 791281 aggctttgaa tttaaaaacg cctggacggg aagacgatga tgtggatgaa gtgctggatg 791341 aaaatactgt tcaggatgta aatgaaaaca tcatgctgaa agggctcggc ggaaaagaaa 791401 accttcaaac cattgatcat tgcgccacaa ggctgcgact gactgtgaag gataccgctt 791461 tggtggatga agcactgcta aagaaagcag gcgcaaaagg ggttgtcaaa tcgggcgggc 791521 aatcggttca agtcattatt ggcccgaatg tggaatttgc agctgaggaa ttgagggctg 791581 ctgtcaaata aaaaagcgga gagggcaacc tctccgcttt ttcttattta tcttcgttat 791641 cctttgacgt ttcggaagaa tcttcgtcat gttttgtgta atcataatca gaaggattca 791701 ccttcttaaa acctttcggc tcgtagaacc gcagcaggtc tccgtttatg attttatcgg 791761 acatttcaag ttccttcttg acgagtgagt cttctgactt gtcgacttcg gattcatcga 791821 gttcttttcc ggttttcgtg tcgtaatact taccggatat tttcgtgtac ttcggtgaaa 791881 taaagtctcc gtttcggaac ggaatcactt cacggtgttc tttcgataaa atatcagaac 791941 cggacatcag atagtccttc gtatccactc cgagcagatg cagaatggta ggagccacat 792001 caacgtctcc ggcatattta tgaactttct cgcccttcac gccggcagcg tggataaaga 792061 gcggcacccg ttgaagctgg gcgttgtcgt aatcagtgat ttcatccttg ccaagcactt 792121 tcgccatcgc tttattgtgg ttttcagaga tgccgtagtg gtctccgtac atcacaataa 792181 tcgatttatc atataacccg tcttttttca gatcattgaa gaattgttca atggactgat 792241 caaggtaatg ggctgactgg aaatagttat cgacgacaga gtcaccaaag tctccagccg 792301 ggaagtctgt atccccctca tccattccga atgggaagtg gttggaaagg gtaatgaact 792361 tcgtatagaa cggctgcggc aggctttcca gcagcggcat tgattctttg aagaacggtt 792421 tgtctttcat gccgtagttt ttcgtgtttt cttcgttcat gtcatagtaa gcagaatcaa 792481 agaatttatc aatgccttcc gccttgtaca tttcgttacg gttccagaac gtctgcgtgt 792541 tcccgtggaa agtagcagat gtgtaattct tagacttcag aatcgccgga acggattgca 792601 gcgtgttttg cgctttgttt acgaaaactg aaccttgagc cagcgggtac agagagtttt 792661 ccatcataaa ttcagcatca gatgttttac cttgtcccgt ttggtggaaa aagttatcaa 792721 agtagaacgt ttcgttatca tgtgccagtt tatttaagaa tggtgtcact tctttgccgt 792781 caattttata gtcgatgata aatgactgca aagattcaag tgaaacgtaa atgacgtttt 792841 ttccttccgc tttgccgaaa tacacgttat tcggcacatc gtaattggct ttcatgtagt 792901 tttctacttc cgttacgtcg ctggaatcgg caagcgcgcg ctggctgttg gacttgatat 792961 tctgtacagc gtcataaatc gtgaaattgt atgttcccaa gtatttcaca agatagttcc 793021 ggtcgaatga tcttgtcagc aattcaggac ggtctgattc cgcaactgcc aggttgatca 793081 agaacacaag aattgaagac gcaaaaataa ttcggaacga ttttttgctt gacgtttcgg 793141 caggcttgtt tactttgatc gccaagatga tcaggatgat cgtatcgata aagtaaaagg 793201 cgtcagtcgg tctcatcagc gaaaatgcgc tgtcaccgag ttggccgccg tttgttttag 793261 cctgcataat gaccggaatt gtaataaaat cattgaaaaa tctgtagtac acaatgttgg 793321 cgtacagtaa aaaagacatt aaaaaatgaa tcactataat ggctgtctgc tgtaattttt 793381 tcttgaacaa gagtccaaag ccaagaaaga acaagcttga gctaagagga ttcacaaaaa 793441 gcaatatttt ttgtatcgtg ttgtctattc ctaagttgaa attcaggaca taaccgacat 793501 acgttttgat ccataacagg acgaccgcaa ttaagaagaa ggccagtcct ctttctttta 793561 taaatgtttt cattgttaca ctcctttttt ccgatccagt tcgagcgaaa cgatagaaaa 793621 aacgaacgta tccaatataa cacgaatcag cagattagaa aagtgaaaat cgtatgaggg 793681 agaaagtggc gaaaaacgcc gtcgaatcaa cgtttcgctt tgatattacc aaatgtaaaa 793741 caaggtatct ttctagaaat aaaggaataa aatggtacat tgagaattgt atgataaaat 793801 ataaggtata gataaaaaga ggtgaaatga tggatttttc ccatattgtg tctgaagata 793861 aaattaagcg cgccatcaaa gacggggact ttcaaaacct cccgggaatg gggaagccgc 793921 tgccgaagga tgacgcggca cacttgccgg aatcgctgcg catgggctat cgtattttga 793981 aaaacgcggg aatggcagag gacgagggcg cgctcaaaaa agagcttatg accatcgacc 794041 atttaatcga aaagtgctat gacgaaaaag aacgcgagca attaatcaga aaaaaatctg 794101 aaaagcaatt gctgcttgat aagcttgtcg acaaaaaagg catgttttca aagccagcat 794161 ccgcttttta taagaataaa gtatatgacc ggcttggacg aaacagacct tcttccagct 794221 gatttgtctt gtctgcagga tggcgattga taaaagccat cctttttatg ttccaagttc 794281 tatgtcaaaa ggtttatgtt tttccatcta tgggaaatga ttcataaacg aaaaaagggt 794341 gatgggatgg aacgactatt agtatggata gagcatatat ctgattggct gtggggtccg 794401 ccgctaatca tcctgctgac ggggacgggc ttgtatttca ctattttgct gaaaggtttt 794461 caatttcgct atcctttata cattttcaaa cagacaatcg gcagtgtagg aaaaaagccg 794521 aagggagaag gcacagtcac accgcttcag gcattgacct cagccctcag ttcaacgatc 794581 ggtgcagcga acattgtcgg tgtgcccgcc gctattatgt ttgggggacc aggagcggtt 794641 ttttggatgt ggcttattgc cttatttgcc atggcgatta agttttctga aagtgttctt 794701 gctgttcatt acagagaaaa aaatgagcag ggtgaatacg tcgggggacc gatgtattac 794761 ataacaaaag ggctgcgcat gaaatggctc ggcgtattct tctctgttgc gctgattgtg 794821 gagctgattc ccagcattat ggttcaggga aattcggttt cagtctcgct tgccgagacg 794881 ttttctttca ataaaatata cgcaggaatc ggaattgcat ttttgattgg gttagtggtg 794941 ataggagggg taaagcggat cggaaaagta acagagtttg tcgtgcctct tatggcaggg 795001 gcatacgcag gtgccggtct cctgattgtt ctcatgaatc tatcatcagt gccggcgttt 795061 ttctctctcg ttttttcaaa tgcgtttacc tcttcttcag cagttggagg gttcgcaggt 795121 gctgcgttgg cggaaaccgt tcgctgggga tttgcccgcg ggctgtattc taatgaagcc 795181 gggatgggaa cagccccgat tgcacatgcg gcagcaatga ctgatcatcc tgtgcggcaa 795241 gggttttggt ctgtgatcgg cattgtcatt gacaccttaa tcatctgtac gactaccgct 795301 tttatcgtcc ttgcatccgg tgtatggaca gggaagaacg cctcaaatga cccggcagca 795361 ctgacaacgg ccgcatttca gcactatttc ggttctggag gaggatactt cgtttcggtt 795421 tccctggtct tctttgtcgt atcaaccatt atggttgtca ttttttacgg cgtaaagcaa 795481 gctgaatttc tgttcgggcg gctggcagga catgtgatta aattcgttta tttagcggct 795541 attatcatag gtgccgcagg cggagcaaaa gccatttggg gcgtattgga cttagcattg 795601 gtttttattg ttgtcccgaa tgtgattgcg ctcttgttat tgagcagaaa ggtaaaagcg 795661 ctgtacaccg aattctttac atctgaacag tactacctga aagatataag aaaaacgaaa 795721 caaaagcctg tttatccaac aaaagaagct aaaaattcct agtgttttgc ttttgcgccg 795781 aacaatgctt tgctttttat gatcaaataa atgagtaaag gcagcaaaag agaaatcact 795841 acattaatga ttggtttgat tctgttaaag tcgattagct gatttgtatt taaaaaaaac 795901 caaaagccgc atacgactga gaacatgccg gttggtgtat acatggcttt cgggtcgatt 795961 tttgagtgta aaaacgaaag gccgtatacc acgatatata gggaacctgc tatcttcacc 796021 ataatgaccg gaatccaaaa agccgcgatg atcaggtctg agcgatccag aaaatccgta 796081 atgcggatct gcctgatgac catataagca ggatcaaaga aagtagatgt caggttggga 796141 ccaaagacag aaattgaaga aaataacatc acggccagca ataaagcgcc cagcagtatc 796201 gcgaaaatgg tgtattttag cgggacgctc cggtttgaga agagaagcgg aaggataatc 796261 aattccccca ttgtcccaaa cgcgtaatag cctgattgaa ggtatgggat tagaccttca 796321 aaaacaggtg tcaagttttg aagctcaatt tgtgtggcca gcgtaaatgg aaggaacaag 796381 accaggatgc cgaatggaaa taggaatatc tgcgccattc tggtcaatgt ttcttttccc 796441 tctctggcaa tacagatcgc cacaaagata ataacaccgc caagaacagc cattggtgtt 796501 ctcgggagaa ataaaatgtt aatcaaattg atgaaaaaac gtatatcatg agcattgatt 796561 aacaggaaat acaaagaaaa cagtaaaatg ataatccggc ctgcgattgg tgaggaatcg 796621 ctcagcagct catagatatt tttatcctga tgctttttca tcagcctatg catgagccag 796681 agtgccggaa tcacgatgac aacgccgagg atgtagctgt gccaggcatt ttgttttgct 796741 gattcgatca tgagaatcgg agcatgcttt aatccgactg ctaacgtata cagagctccg 796801 aaaaataatc cttggtatgc agaggtcttg tccataaagc acatcctttc tgtcatgttc 796861 aaaacggaat atatttaaac aggtgcccca gccgcggaag caggggattc actctcatat 796921 aaatccatag aaaagcactt cctgcaatta gcaggctgaa ggcccatttt gttagattgt 796981 tagcggaacg aaaattcttc cattcatatg cgtatatggc aatgcacaca atcaatgtct 797041 gtacgatata gctgatcatg ctgacgcacc tccattaatg gctgatcgtt ttgtatagga 797101 caccgccctg ctcaatcgtc acaattggga cgacgtgaac ctccatatcc ttatatacct 797161 cttcccattc ctttttcagc agattcttcg tggttgccgt gcttctgatg gtcctgtctt 797221 gaaagccggc cgggtccgcc tttagctttt gcaaacgatg aacggtgctg atcacgtcct 797281 tctttatggt tctgtttaat gctttttgaa tgatgtaata ctggtcattt tctctcgtct 797341 cataggttga ttggttttcc ataataattc ctttggctct gatctcgatt gtcattgaca 797401 gctttccgtt tttttcagcg gcatgaaagg atgcattgga cttttgaagc tgaatggatg 797461 cttgccccat ttgattcggc aggtctacta tgaattctgg ctggcgggct tgattcagca 797521 acatcagggc tgctgtcatg tgttcatctt tgaaaatatc catcaatctg tcctttttaa 797581 agatcgcaag cccgtcaatt ttcaaattag atttgccttt ccctccaggt tttgttttag 797641 atgcagagat gaccggtgca tacggatcac tgcctatttc tactagatca gacatgaatc 797701 tgcttaagaa aacggggcgg ctcgttgcga taatggccag ctcccgaatc atttccgccg 797761 gaaactgttc aagctgaaca tcggtattta aaatgtcccg cgcttctccc cggctgacta 797821 aaatgagcgc cgttaatctg ttctgcggat ttcgcgttaa aatatcaaag actggggcaa 797881 cgccgtctct cgccatatcc tctccaataa tgactgtacg tctgtgggac gtattgattg 797941 tccgtgacaa ggaggtttgc agcttgttgt tcgcttctct gatcgtagtg ccggaagctg 798001 aatcaacata ccatgttttt gaaccggcag ttccgccgcc gccccctgtt tgtccgccta 798061 attggccgac caagggaatc tgcatggcca ctcgatactg atcttttttc ttatcaatgg 798121 ctgagctgac aacaaatgca atgtcattga tttctgtccg gtcccagcac cccgttagaa 798181 ggatacaaat gagaagcggc aaaacacact tatatattgt tttcttcatc ttttgggtcc 798241 tctcttttcg ctcccttctg tccgttgccg cgcgaatacg tgcccggcct tctggtcatc 798301 gtccaccaag gcgccctgac aaaaatatct tttacttcat ctcgtttaaa cggagaaatc 798361 ccggataaat aaggaatgcc gaaagattgc agcttgcata aatgaagcac taagataatc 798421 gtgccgagca taatgccgaa tatcccaaaa atactcgcca aaaacataag cgggaaacga 798481 agcatcctga tggagatagc taagttaaac cgcggaattg taaatgacgc gatccctgtt 798541 aacgatacga tgatcaccat gggggcagac acaattcccg cttcaacagc ggctgtccca 798601 atgactaggg ccccgagaat actgacggtc tggccgatgg ttttcggcag gcgcactccc 798661 gcctcacgga gagcctcaaa agaaatttcc ataatcaatg cttctatgat ggcggggaaa 798721 ggaatcggtt cacgcgcaga ggccacactg aacattaagt ttgtcggcat taagtcctgg 798781 tggtatgtaa taacggcaac ataaatagcc ggcaaatata aagcaacgaa taaaaacata 798841 tagcgaagcc agcggattaa gttagacatc aaataacgct catagtaatc ttcactggcc 798901 tgcataagct gccaaaacgt aatcgggcct gttaagacaa agggcgtatt atctgtgaaa 798961 atggcaaatc ggccttcgag aagctgggcg gcgacggtgt ccggcctttc tgtgtattgc 799021 agctggggga atggcgagta cgtgtcgtct tcgataaatt cttcaatata tccgctttct 799081 aagacagcat caatctttat ctttttgatt cttttttttg ctttgtcaat aacctttgga 799141 tcggcaagcc cgtcaatata ggccaagaca acatcggttt tggttttcgt gccgatttta 799201 aaagagatca ttttaagctg aaacgttttg acgcgaaagc gcacaagagc ggtattgacc 799261 ctgaggcttt cagtgaagcc ctctcttgac cctctgatgg tcgattctgt tatcggctct 799321 tcaatgcttc ttctttgtcc gccttttata tttaagatca ggccttttga gtgcccgtcg 799381 gcaaataaaa ccgcgttccc ctcaatgatg gatgcagcca ctttgctcat actcgtttct 799441 aatgcaacac ttgaaattga tagagtattt tgcagcgcct cttcatgttc atctatttga 799501 tccgtcaaat gcattaagaa agggcggagg gcgtgatcct gaatatgttc agattttaca 799561 attccttcga tataaacaat aaatccgcac agcccgtttc caaagtcaaa ttgtctaaat 799621 acgatgtctg agcagccttc tgttaataag gtcagatttt cgaggttttc cttcaaattg 799681 ggagagatcg gtctgtcctg attgtcttca agctctttga tgagctgaag cgctttgtcg 799741 cgtttattca tagaggctca ccctgctttt taatgtcata ttcaataagt gcttgtgact 799801 tttagggtaa ccttgtctgt ttcatatatt ccagactagg atgaaagcgc tataaaaaag 799861 tgttgactac ctgtatatac aggaatacaa tatgattata agttgtatat acaagttata 799921 aaaacggata cggaggggtt ggcatggggg aactgaacaa atcggcacgt cagattgtcg 799981 aagcagtcgg cggtgctgaa aatattgcag cggcaactca ttgtgttaca cgtttgcgtt 800041 ttgctttaat agatgaaagc aaggttgacc aagagatgct tgatcaaatt gatgtggtaa 800101 agggatcatt ctcgacaaac ggacagtttc aggtcgtaat cggccaggga actgtcaata 800161 aagtatatgc tgaactggtt aaggaaacgg ggattggcga gtcaacaaag gatgaagtga 800221 agaaggcctc agaaaaaaat atgaatcctt tgcagcgtgc tgtgaaaacg cttgcagata 800281 tttttattcc aatattgcct gcgattgtca cggcgggtct tttaatgggg atcaataaca 800341 ttttaacggc ggaaggcatt ttcttcagca caaaatcgat tgtgcaggtt tatccgcagt 800401 gggcggatct tgctaatatg attaacctga ttgcaggcac ggcctttacg tttttgcctg 800461 cgttaatcgg atggtctgcc gtcaagcggt tcggcggcaa tccgcttctc ggcattgtgc 800521 tcggggttat gctcgtgcat cctgatttgc tgaatgcgtg gggatatggc gcggcagaac 800581 aaagcggaga gatcccggta tggaatctat tcggcctaga ggtgcagaaa gtcggctatc 800641 agggccaggt gctcccaatt ttgcttgctt cttatatgct ggcgaagatt gaggtatttt 800701 taacaaaacg cacacctgag ggcatacagc tgctcgttgt cgcaccaatt acgcttctct 800761 taacaggatt tgcctctttt atcattatcg gcccgattac atttgcgatc ggtaatgtac 800821 tgacttcagg gcttatctcg gtgtttggtt cttttgccgc actgggcggt ctgttatatg 800881 gcggtttcta ctcagcgctc gtgattaccg gtatgcatca cacgtttctt gcagtcgacc 800941 tgcagctcat cggttcaaag ctcggcggca cctttttatg gccgatgctg gcgctttcta 801001 atatcgcaca aggttcggcg gctctggcca tgatgtttat cgtgaaggat gagaaacaaa 801061 aaggcctctc cctcacatca gggatttctg cttatcttgg cattacagag cctgccatct 801121 ttggggtgaa tctgcgatac agattcccgt ttatcattgc aatggtcagc tctggcctgg 801181 ccggaatgta tatttcttct caaggtgtgc tggcaagctc cgtcggtgtc ggcggcgtgc 801241 cggggatttt ctcaatcatg agccagtact ggggcgcgtt tgcaatcggg atggctattg 801301 tattgatcgt gccgtttgcc ggaacatacg cgtatgcgag attcaaacat aaataacaag 801361 tggggagcgg gacgtgttga acgttccctt ttcccgtttt caatttaaat atggtggtgg 801421 aaacagatga aaacagaaca aacgccatgg tggaaaaaag ctgtggttta tcaaatttat 801481 ccgaaaagct ttaacgatac gacaggaaat ggtgttggcg atctgaacgg cattattgaa 801541 aagctggatt acttaaaaac gctacaggtg gatgtgcttt ggctgacgcc gatttatgat 801601 tctccccagc atgataatgg gtacgatatt cgtgattatt actcgattta tcctgaatac 801661 ggaacgatgg aggattttga gcggctagtg tccgaagcac ataaaagaga cctgaaagtc 801721 gtcatggatc ttgttgtcaa tcatacgtca acagagcaca aatggtttcg cgaggcgatc 801781 tcttcaatag acagcccgta ccgtgatttt tatatatgga aaaaaccgca ggaaaacggt 801841 tctgttccga cgaactggga atcgaaattc ggcggctcgg catgggagct tgacgaagca 801901 tcgggccaat actatttgca tctgtttgat gtgacgcagg ctgatttgaa ttgggaaaat 801961 gaagaggtca gaaagcatgt ctatgacatg atgcattttt ggtttgaaaa gggaatagac 802021 ggctttaggc ttgatgtcat caacctgatt tctaaagatc agcgctttcc gaatgcggag 802081 gaaggcgacg gccgctcttt ttacactgac gggccgcggg tgcacgaatt tctgcatgaa 802141 atgaacgaaa aggtgttttc acattacgac agcatgacgg tcggtgagat gtcttcaaca 802201 accgtagacc actgcatccg gtatacgaat cctgacaata aagaacttga tatgacattc 802261 agcttccatc atctcaaggt tgactatcct aacggcgaaa aatgggcctt ggcgccgttt 802321 gattttttga agctgaagga gatcctatct gactggcaaa cggggatgca cgcaggaggg 802381 ggatggaacg ctctgttctg gtgcaatcat gatcagccgc gcgtcgtatc aagatatgga 802441 gatgatggcg catatagggt gaaatcggcg aaaatgcttg ctacggccat tcatatgatg 802501 cagggcacgc cttatattta tcagggcgag gagctgggga tgacgaatcc gaagttcact 802561 gacataagct cctatcggga tgtcgaatcg ctgaacatgt atcacgcctt taaggaaaaa 802621 ggaatggctg atcaagatat tacagccatt ttacaggcga aatcccgtga caattccaga 802681 acccccgttc agtgggatgc tacggaaaat ggtggtttta caacgggcac accatggata 802741 ccggttgcag gaaattaccg ggaaatcaat gctgaagcgg cgctgaggga tcagaattcg 802801 gtgttttacc attatcaaaa attgattcag attcgcaaaa tgtatgacat tgtgacagag 802861 ggtacgtatg agataattgc aaaggatgac ccgaacattt ttgcgtatct cagacacggc 802921 agcaatgaaa agctgctcgt gatcaataat ttttacggga cagaggcggc ctttacactg 802981 ccggactctt tagcgcctga cgaatggaag gcagaggtgc tgttgacgaa cgatgaagca 803041 agggaagggc ttcagaacat gacgcttcgc ccatatgagt ccattgttta tcgtttaacg 803101 aaaccgtgtt aaactaagct gggtggtcca taatgaaggt gaataaattc atcacaattt 803161 ataaagacat cgcacagcaa attgaaggcg gccgatggaa agcggaggag attcttccgt 803221 ctgaacatga gttgaccgca cagtacggta catcaagaga aacggtccga aaggcgcttc 803281 atatgctcgc gcaaaacggt tatatccaga aaatcagggg aaaaggctcc gtcgtgctca 803341 atcgtgaaaa aatgcagttt cccgtttcgg gccttgtcag cttcaaggag ctcgcgcaaa 803401 cgcttggcaa agaaacgaaa acaactgtac acaaattcgg gctggagcct ccgtcagagc 803461 tgatccaaaa acagctccgg gccaatctgg atgacgacat ctgggaagtc atcaggtcta 803521 gaaagattga cggggaacat gtgattttgg acaaggatta ctttttcaga aagcatgtcc 803581 ctcacctgac gaaagaaatt tgtgaaaact ccatatatga atatatagaa ggagagctcg 803641 gtctttcgat cagttacgcc caaaaagaaa ttgtagccga gccgtgtacg gacgaggaca 803701 gagagctgct cgatttacgc ggctatgacc atatggtcgt ggtgagaaac tacgtctttt 803761 tggaggatac cagtttgttt caatatacgg aaagcagaca ccgtctcgac aaattccgat 803821 ttgttgattt tgcgcggcgg gggaaatgag agaggcgcct gcctgcggca gcgcgctttt 803881 ttgtttggta tcaaaattga tactatccaa caaaaatgtg cgtactttta ctttttatca 803941 taatggctac aatagagatg agagtaatct aaaggagagg tgttttacat ggcagatcta 804001 aagacacaaa ttctggatgc atacaatttc aggcatgcga ctaaggaatt tgacccgaat 804061 aaaaaagtgt cagacagcga ttttgaattt attttagaaa caggaagact gtctccgagc 804121 tcactcggcc ttgagccttg gaaatttgtc gtcgtccaaa atccggaatt ccgcgagaag 804181 cttcgtgaat acacatgggg cgcgcaaaag cagctgccga ccgcaagcca tttcgtcctg 804241 attcttgcgc gtacagcgaa ggatatcaaa tataatgcgg actacatcaa acgtcattta 804301 aaagaagtaa aacaaatgcc tcaagacgtg tacgaaggct atttaagcaa aacagaagaa 804361 ttccagaaaa acgatttgca tttgcttgaa agtgacagaa cattgtttga ctgggcatca 804421 aaacaaacct atatcgcgct tggcaacatg atgactgccg ctgcgcaaat cggtgttgat 804481 tcctgcccga tcgaaggctt ccagtacgat cacattcacc gtattcttga agaagaaggc 804541 cttctggaaa acggaagctt cgatatttct gtgatggtgg cattcggcta ccgagtgaga 804601 gaccctcgtc cgaaaacaag atctgctgtt gaagatgttg tgaagtgggt ttaaaagaag 804661 aaagctgctc gcatagcgag cagctctttt ttatgcctga ttcgctctat tctgttttct 804721 cctctgatgt aagtacattg ccgttccgag tgcgctgatc agaaatccgg ccaacaggat 804781 cgagtacatg gatgtggctg tgtccggaag caggccgcca gccggaccgt ctgttcctga 804841 tccgcccgaa ccgtttccac cagagccgtt agtcggttga gtgccgggag gcgtatcatt 804901 tcctccgttt ccgtcagttg gctgttttcc gcctggtttg tcggagcctc cgccatgatt 804961 gccgtcatca ccgcctgtcg gttgatctga cgggaatgcc ggcggtttgt tgtttgaacc 805021 ggaatttaag atcgtgtatt cgctgaagtg gtttgtatat cctgtcacca tatcatcatc 805081 gactgatccg tgacctgtct ttgtgaaagc tttctttttt ctatcgacgt gataaatggc 805141 agggttatgg gcttcttcaa tatcaaacat gcgaagcgaa agctgtacgg gctccttgaa 805201 tgattttatt tcttttcctt tttgcttcac tgtaaagtca tatacatctg acagtgacac 805261 atccaattct cccgtagact tgattccgat tgcagtgtct gcggttttaa ggttcgccat 805321 tggcatcttc atgctgtacc agtagttgaa catcgtcaat gaaggatctg actctctttc 805381 tttcaaaagt ttgacctgat cttttttcac tttaagattg ataggcttct cttgagatcc 805441 ttcatgtatt ccataataga caaatggcgt gttggcattt ttagcataaa tcgcaaattt 805501 gtcttcatca agtgtccagc tgccgtcctt ctgctttgtc ggcaggaata cttctttgat 805561 tcgtccttca actttaggag agaccttgtt tcctagtttt ttcagctgtt cggtgaaaat 805621 ctcataatca acgtagccaa ggtcttcacc atgggaggct tctgtaaaga cagaatatcc 805681 gtctcctccg gcaccgacaa aattatttgt tgccacgcgg taggtatcat ccgtatttat 805741 agcaactttg tctccgttag gcgattcaat tttcacttct aacacacggt gtccaggttt 805801 gttgtttaat gtaaaggtat attcgattcc ggccacctga gggaaagcgc cgccgccatt 805861 ttccacattg cttaggcctt gttcaagggc ttctttaatt tgttttccgg ttaaatcggc 805921 cacgtaaagc gtattgccga acggcatcac gttgagcacc tcgccgagtg tgatatcacc 805981 tttgtcaatg cctgctctga tgccgccgcc atttgttatc gctattctgg cgccggctgc 806041 ttctttcgct tttgccagca taccgtccgc gatgaagttt ccgagattcg tttctttcgt 806101 gcgcacatgc tcacgctggc cgtcaagcgc cacatccgtg tagccgactt tttcattttt 806161 cacgtcctct aattcatttt tgaactgatc gagctcttgt tttgcttctg ggttttcttc 806221 tgtatgttca tcaattggca gcacgctcag atttgattta tctgtttgca caacgccttt 806281 ttcatcaaac gcgacatcaa cgcgccccaa gaattggccg tattcttttg cctgcgccac 806341 gatcgtcggt tcttcgttgt tcacgacctc cattttgtct acgagggtgt gagtgtgtcc 806401 gccgatgatc aaatcaatgc cttttacttt tttggctagc tcaagatccc ggttatgtcc 806461 gatgtgggtt aaagcaataa ttttatttac cttttcttct tcttgaatcg ctttgacggt 806521 gttttgtgct gtttcaaagg catcattgaa tacgatgctt ttgcccgggc ttgatgtggt 806581 ggctgtatct tctgttgtca ggccgaatac ggcgactttc tccccgtcaa cgtctaacag 806641 aatgtaaggg tgaatgccgg cctctttctt ttcacctgcc gtaaaggttt gcggcttttt 806701 gacaaatgat ttcagcttgg gctcatttga cacatctacg tttgcactga caatcggaaa 806761 ttccggcgct tcaaagtgat agcggttcgc cggatcaacg gttgcgctgt ttccgcttag 806821 aaaatcagaa agcaccgtcg ggcctttgtc aaattcatgg tttccgaagg tcatggcgtc 806881 atagcccatc atgttcatca ttttcagatc ggccaaaccg ttccatttag taaaatacag 806941 atcgccggaa aacacatctc ccgcatcaag gagaatattg tgatttgttt cgctgcgtac 807001 ttcgttgatt ttcgtcattc gtctcgctgc atcatcgaga tgggcgtgcg tatcattggt 807061 gtgcatgacg gtcagatccc acagtccgtc tttaggagga tctggatttg aatcatcatc 807121 gaattgcagc ttatacacac catagccttc attcgcagac ttgcctacat aagcgacatc 807181 gtctgcttta tcggcaaatg gcttggccaa aagcgaggat tcaaacgtca gattcgtgcc 807241 ggaaacaggc gcgattgacc agttgttgtc tgcttttgga ttgactgttt tttgttcaat 807301 aatgtaatcc atcagcacct gcctattttc aactgcagag ccgtggacaa ttttatcgct 807361 cgtcagatga gggaacccgc cgcctccgga cgcacgatag ttattggtga ctacgagaaa 807421 ttcctggctt gggctgatcg gcttgccttc ataggaaaga ttgatgatac gggatgaatc 807481 cgcattgatc acttttccgt tctcattgta tttagccggt tttgtcacat cgacctgata 807541 tgtgacaccg tcaatcacgt caaaattata ggagcggaaa ttctcgttca gcaaggcctg 807601 gtcgccgcct ttagctggat caatttgatt gaattggcct gctgacatct ccagccagtc 807661 cttgacctcg ctgcctgtca gcttgacgat ttgaacagta ttatcgtaaa gatacaagtc 807721 accgacattt ttaatcgcaa gatctccggc tggaatgttt gtatagtaat tggctccgtt 807781 tctgccgcct gctttaaacg gcgctccagc ggataaaatc ggcaggttct tgtactcggt 807841 atccttcatt tctttttcag cgtaccactt ttgcgcgtca gtcacgatct gaatggaagg 807901 atcatctttg acctgtgcaa agaagctgtt aatatctgct tcggttttgc cgactggctt 807961 tcggacatac tccagtgtgt tttggtgtgt ttgctgaatg gtgtttgtaa cggtttcgtt 808021 tcttgatgtg acgttgccag caatagattc aatacttcct ttggaatctg ctaccttcca 808081 tgagccgtcc gccttttcaa gcttgaggtc aatcacgcct aaatatttgc cccagctgct 808141 tggcatgacg acaggaatgc cgttaattgt tcccttttcc acattgaact gagcaacacc 808201 cgcatactcg gcggaaggaa agagtccgtg ctgatggccc gagataatcg cgtcaatgcc 808261 tttcgttttg gtggcaaggt caaacacggc gttttctgcg cctgatgatt gcgcctgctt 808321 ttcaatgccg gtgtgggcga gggcaataat gacatctgcg ccttccgcct tcattttcgg 808381 gatcgtttca ttggcggatt ctacgatatc ctgcacctga acttgcccct cgagattctt 808441 tttgtcccat gtcatgattt gcggcgggac aaagcctatg tagccgactt ttactttctg 808501 ctcattaccg ttttcatcaa tgagggtttt ttcattaatc acatacggcg tataacggtt 808561 ttcgccgcta gttgttttga cgttggcatt tacaatcggg aaatcggctc ctttgattgt 808621 gccgtcgaga aagtcgagcc cgtagttgaa ttcatgattg ccaagcgttc cggcgtcgta 808681 tttcagcgca ttcatgacgc tgataatcgg atgggttttc gtgccggaga taatgtcgtc 808741 tttttgatat ttcaccgcgt attcacccag cggattccct tgaatcaagt cgccgttatc 808801 cacaagcagg gtgttagggt tttgctcgcg gtgcttttgg atcaattgcg ctgttctcgc 808861 cagaccgaaa tccgccgttt ctttgtcgct gtagtaatcg taatccatca tgttggcatg 808921 aatatcagtc gtagccaaaa tactcagatg cacctgagga gccgcgcttt cttctgcatg 808981 aatgggtggt gttgggagga ttaggctaag tatcataatt gggggcaaaa gaatacggag 809041 aatgttttcg acgtgtgttc gtcttttctg tattctcacc agttctccac ctttcaacga 809101 aatttgtgtt acagctccta ttgtaagaat attttgtaac tatttgtagg tgtttcttta 809161 tgattattgt aaaagggaga aaaatgagta ttatgtagca gtatcaaacg acaaatactg 809221 ggcatttatg cttatcgttt gtcacaatcg cggaatgttt attttagtgt ggctggggta 809281 gagtgtttta tgtagacata taaagcggga ggttatgaat catggggaaa aaaattgcag 809341 ttgttttaac atattatttt gaggacagcg agtacactga gcctgcgaaa gcctttaaag 809401 aagcgggaca tgaactgact gtcatcgaaa aagaaaaagg aaaaacagta aaaggcaagc 809461 agggaacagc ggaagtgacg gttgacgcgt ccattgacga cgtaaattct tcagactttg 809521 atgcgctttt gattcctgga ggattttcac cagaccagct tcgcgctgac gatcgtttcg 809581 tccaatttac aaaagcgttt atgactgaca aaaagccggt atttgccatt tgccacggcc 809641 cgcagctttt aatcaatgcg aaagcgctcg acggccgaaa agcgacgggc tatacgtcca 809701 ttcgtgttga catggaaaac gccggtgccg acgttgtgga caaggaagtg gttgtttgcc 809761 aggatcaatt ggtcactagc cgcacaccgg acgatatacc ggcatttaac cgcgagtcat 809821 tggcattgct tgagaaataa gaaaaaacgg acgctcttgg gcgtccgttt ttttgttgct 809881 taggcttgag cacctgtcag tttcttgtac ctgtaataca agaaagcagc tgcagccgtt 809941 ccgatgaccg caatgccgaa gtcgaatatg aaaatatggg cgatgccccc cgcttttgcg 810001 ataagccctg ttgcaatcgg cagcagaatc gatgcaagac ttgaagcagt cgctacaatt 810061 ccggtaacgg ttccttttcg cttccagaaa agctctgtca ttaacgtaat ggtaatttga 810121 aacacacccg cagttgaaaa gcctaagaaa aaggcagtga tgtccagcac aactgggata 810181 tgaacggtca gcatgactgc gagcgtacat aaagtaataa taggatataa gagcgttatg 810241 aagacaggtt tgacccatct attcagcaaa acggctaata ataaaacaga tgccagagat 810301 cctatactat aatagctcag caattgtaca gatgctgatt cagctaaacc ggctgccttt 810361 tgcgcgtagc tcgggagcca gatttgagaa accgtaaata aagccgtgga tgtaaaaccg 810421 atgataatca gtgcggtgcc ttccttctga aaaacgggtt cagacaagaa aacgggagat 810481 tcctgttggc cgctattagt tggtttctta tgttttttag gaaacgaaag cgttgataaa 810541 taaataatat tcaggagata gaccgctgcc ggcagataaa aagcaaatcc gtaaaacatg 810601 ctgtggtctg ctaaaaatgt gatcaaaagc ggcaaaagtg cggcccccac agacataaag 810661 gctttaacca agacatttgc cgaaccggaa gcagacggaa agagctcggt tagggccgga 810721 tatgttccgg catccatggc tgaattagcg actccggcta ataaagcgaa cacaaacgcc 810781 agctcatagc tcggtgataa aggaataccg actaaaaaga cggccataat tcccgcagaa 810841 gcgacaacaa gcggctttct gccgatttta tctgatagaa cgccggaaat gccgtatgtc 810901 agcagtttgc caaacccgat agcggcaatg acataactga tgccggtcgg atcggtattc 810961 cactgttttg ttaatgaaga catattggat gcgagaatga tgttgaccat ccccagaaag 811021 aagtagttga tatacattcc ggatgctgtt ttgatagatg tcgtttgcat gcttgtactc 811081 cttcaaatct tattcgaaca ctttgctgtt ttggtttggg gaaatgataa aaaagactcg 811141 ccgagtttcc ggccagtctc cattatttac gaagcgaggc taattcttga gcaatcgcct 811201 gcatttcact tgggctgaat gattcttttt tcatcaccat tctgtgaagg tacgtgaggt 811261 cttcaatctt ctcatcactg aaatcctccg ctttgattac gccgacgttc agcatgttca 811321 gcttttggga aatctcttca atcatttgag ttaatgtttc tgtatttggg ctggacaaag 811381 ggttccatcc tttctatgcg caatataggt atgttttatt ctaacagaat tccatcagaa 811441 aaaaacccta ttctaaaagc aggctgttca ttccaaaaaa gtgaagacat cagttgaaaa 811501 gaaaatgaac atcctactaa gatattcatg aaggtttctt tttagagaaa taggggcaaa 811561 gaatagggag gttgcacatc atgataagcg tgttatttgt ttgtttaggt aacatttgcc 811621 ggtctccgat ggcggaagcg atttttaggg acctggcagc caaaaaagga ttagagggga 811681 aaatcaaggc ggactcagcc ggtattggcg gctggcacat cggcaacccc ccgcatgagg 811741 gaacgcagga gatattgcgc agagaaggaa tcagctttga tggcatgctg gcgcgtcaag 811801 tcagcgaaca ggatctggac gattttgatt acatcattgc aatggatgca gaaaatatcg 811861 gaagtctcag aagcatggcg ggttttaaaa acacctcgca tatcaaaagg ctcttggact 811921 atgttgaaga ttcagatctg gctgacgtac ccgatcctta ctacacaggg aactttgaag 811981 aggtctgcca attaatcaaa acgggctgtg agcagttgct tgcatccatt caaaaagaaa 812041 aacaattgtg agtgaaagga gaatttgcat gaacaacgaa cgtttaatgc tgaaagggat 812101 atttctcgga gctgcggcag gcgcggcgtt atcactgctc cataagccga caagacaggc 812161 gtgcgggatg agatggctga catgcaagca taaactttca ctgtacaaaa gcaacccaga 812221 gctgttaaaa aacactgtca tcacaaaagt ggatgaggcc aaaaagctcg cccgaacgct 812281 ttcaaaggaa gtcgactttg tgaaccagca ggtgaaagag ctgaagaaaa caacgccgca 812341 agtgatggaa ctcgtgcaag aaacgaaaga gcatttttca aaaaaatgat caaacatgcg 812401 aggtgagacg acatgagttt tttgaaagag cttttcagca gatacaccct tcatgaagga 812461 caaagtaaat cagcggagct ggcgtatttt tttctattgt cactgtttcc gtttttgatt 812521 tttatgctga cgctcaccgc gtatcttccg ctttctaccg atgatgtttt aggagtcata 812581 gaacaatatg ctcccgccag tgcgatgtca ctcgttgaat ccattaccca tcaaacctta 812641 aataatcgaa atggcggttt gctgtcattc gggattatcg ccgcattatg gtctgcgtct 812701 aatggaatga atgcgatcgt ccggtcgctg aaccacgcgt atgatgtgga agaaaaccgc 812761 tcttttatca ttgttcgtct aacctcgatt tttttgacga ttgccatggt atttacgatt 812821 ttagtggctt tgcttctgcc ggtatttggc cgggagattg gaaggctcgc ttctgacttt 812881 gtcggcgcgt cggatctgtt tttatccgtc tgggccgcca ttcgctgggg tgtcagcccg 812941 cttgtgcttt tgattgtttt ttccgcgctg tatgtgattg cgccgaacaa aaagctgtct 813001 ctccggtttg tcatgccggg tgcggtcttt gcgactatcg gctggatcat tgtcagcaca 813061 ttgttttcat tttacgtcag cacgtttgcg aactatagcg ccacttacgg gagcatcggg 813121 ggaatcatcg ttctgatgat ttggttttac ttgagcggca ttttaattat cctaggcgga 813181 gaaatcaacg ctcttttaca taaacgtaaa aagcttcctg atgaaaatcc ctaccattag 813241 cgcaccctat aaacgaactt cggttcaaaa agaagtcggg gggatatcgt gatgaccaag 813301 catacgaaaa aaggcggaag ccataacaaa caaaactcga aaagcaaatc gagccataaa 813361 acaagcggaa gcgccaacgg acaaaacggc taccattagc ataaaagcct cctgacatga 813421 tgtcgggagg ctttttgatt aagaagatga agaataggtt tcagccggtg accagctttt 813481 cggtttgccc agcacaaggg ccagccacac agagctaagc gtgagagtaa tgaagtagaa 813541 caagtttgcg ctttcaaatg tctgcatata ccagccgccg gcaactgggc cgaggatgct 813601 accgagactg aatgtaatgc cgcaaagcag gtttcccgcc ggcaggaggt gaggcggaag 813661 aaggtctgtc atatagctga tgccaagtgt aaaggttgat ccgactgcca ttcctgcaat 813721 aaaaaagcag ccgccgatca cgtagggcga aggaaataca ccggcgatga aaaagcaaag 813781 agccccagtc agtaaaatca ccagcagcac attccgcctg ccgtatttat cgctgaggat 813841 gccgagcgga aactgaaaga taatgcttcc aatcgcaaat gcgggaagga tgatcgctac 813901 tgcgtctact gatatcccca aacggagcgc gtacaccgga aagcttccgt tcagcgccgt 813961 ttccagaaag ccatagccaa atgtaggcat aaaggcaacc cacccaaaca gcatggcctg 814021 ataaaatcgc ctgaaactat tgtctgattt ggtttcatga ggactggttt ccgggtatgc 814081 attttgtaga aagaaaacaa aaagccacgc aaacagactg atgcagccgg acacgataaa 814141 aggaagcgac ggactcagct tgacaagcgg caccatgaac gggcctgcgg caaagccaag 814201 gccaaaggaa agcccataaa tagacaggtt tcttccgcga ttttgttttg atgacatgga 814261 ggtcacccac gtttgcgtag aaaagtgaag catgtggtcg ccgattccaa tgaacaggcg 814321 aagcaggaac cagacccaaa ctgactgaag ccaaataaat ccgaataagc ttaaaatgac 814381 aatgcttccg cccatgacga tcagcggctt gaacccgagc tttctgagcg gtgcttccat 814441 aaacggcgaa gccaaaagca caccgatata cagcccggtc gcgtgcaggc cgttgatagc 814501 agcggattct ccatttgttt caaaaatgat tgaaatgaca ggcagcagca tgccttgtga 814561 aaacccggaa atggaaacga gcaagacaag gataaagaaa tgaaatcgtg acatcgtgtc 814621 agttctcctt atatggaatc tatgttgatc gtacaacgtt ttccaaaagc aggcaacctg 814681 aaaaaagcct atatcacgct atacatttgc cctcgtgtaa tcatgaaggt ttttgtgaag 814741 aataaaaata aaacaagtca taaaaaagga gctatttcac catgaatcgt atctttttta 814801 ttttagtggc ggccggtgtt ccgctttctg tgattggcag tttgatgcat tggccttccg 814861 cggttctatt tgcagtttat tgcgtgacga ttatcgcgct tgcaagctat atggggaggg 814921 cgacagaatc actgtccatc attgcaggac cgcgtatcgg cggtttgttg aatgcaacct 814981 tcgggaatgc ggtggagctg attatttccc tttttgcatt aaaagaaggc ctgacaggaa 815041 tcgtgcttgc ctctttaacc ggttcagtgc tggggaacct gttgctggta gcgggcctat 815101 cgttttttgt cggcggttta aaatataagc ggcaggaatt taatatccat gatgcccgcc 815161 ataactccgg gcttctgatt tttgccatca ttgtcgcctt tgtgattccg gaggtattct 815221 ctgttggtat gggaaacgcc agcaagctca atttaagcat cggcatcagc atcattatga 815281 ttctgttata tgtggcggcg ctgtacttta aacttgtcac gcatcggggc gtttatcagc 815341 cgaataatgc cgctcagact gaagaagagg aagagccaga atggtcaggg aaggttgcga 815401 cgattgtctt gtttgcggca acgattgtgg ttgcatacat atccgaaaac ctggtccata 815461 cctttcactc ggtggctgaa cagttcgggt ggagcgagct gtttattggg gtcatcatcg 815521 tggcgattgt aggaaatgcg gcggagcatg cgtcagcgat tattatggcc ttcaaaaata 815581 aaatggacat tgctgttgaa attgcagtag gctctacgct gcagatcgct atgtttgtcg 815641 caccggttct cgtcatctgt tctatctttt ttccgacaag catgccgctt gtatttacat 815701 tgcctgagct cgtcgcgatg gtatcagcgg ttctcttgat gatcgcgatt tcgaatgacg 815761 gggattccaa ctggtttgaa ggggcgacac tgcttgctgc atatgtcatt atggcgatcg 815821 gctttttcct tctttaacct gaaaaaatga tggataacaa caaagcggga tgaaaagact 815881 aagggaaaat gccatagaaa gagtgatatg atgaaaaagc tatttcattc cacacttatt 815941 gtgttgttat tctttagttt tttcggcgtt cagcccatcc acgcgaaaaa gcagtttaag 816001 gttcctaatt ctgtcgcaag catttcaaag gaaaacacgt atccgaatgc ttcacaggat 816061 cagccaatgc ttcagccgag caagctggca aaggaattgc tcgatcattc tgaggtaaag 816121 attgaaaatc cgcatctcat caaaatgctg aatgaatcca acatatccgg cacaccgctt 816181 gcagtagggt accgggcgac aatatttctc gggaaatggg cgctcggcta tgaatcaaat 816241 gaaacagtcg caaactggga atataaaaaa atcaatacaa accgtgcgga taaccgcggc 816301 gggaaagaaa cggctgaaat gcattatgcc caggaacagc agtacagagt gaagggcggc 816361 ttgacagcta aagttccaaa tgctgaagat gtcaaaagca tgatgatgca aaaagcaatg 816421 aagaaaacga acctcccgct tgcatttgag acggtcatcg gggctggcac aaaacgggat 816481 cagatttata aagtcgctcc taaaaaaatc ggttatctac atgcatatgc accggctgtg 816541 aatgaaaaag gaaaagtgac ttacggagaa gtgtacttag tgctgaaagg aaataaacga 816601 aaactcgtcg tgaaaaatgt cacgtcacag ggaatcggcg cgtggattcc ggttcaagat 816661 catgtcacgt ttggctttca gctttcctca ctgccaagat aaataaaaaa ctgattccaa 816721 ctcggaatca gtttttttgt ttattgggtt ctctcgattc ggaccgcttc ctcaagcatt 816781 tgcacattgt tttggtagag ctggcgaacg agaacccgtc ttactgcaag gctggcactg 816841 aaataatcat catctttcac catgccttta accgtaaatt cgacgccgcg attgatttta 816901 ttcaatgcgg tgatgccgtg gatttgaaac ggttctgtcg gattgccgaa ttcatcccgc 816961 ttcaatgaat cacgaagctc ttcattcagc atgtcacatg cctcttccaa cacgctgtac 817021 acgcggtccg gatcttcttt aaagctgata agaaaggatt cggtaatccg cataaaatca 817081 atattatagt tctctatttg tctgacctcg ccgttgctga tggtgagcag cttcccgctc 817141 cattcccgga tttgcagcga gcggaggccg atttcctcca ctgtcccgtt gaacaagttg 817201 ttgacggtga cataatcgcc tttgtgcagc tggcgttcat atattaagaa tacaccagcc 817261 agcacatctt tgatcagcga ttgggcgcca aaaccgatca cgatacctgc tacgcccgcc 817321 ccggccaata tcttgccgaa atcatgcaca aataaagaaa taacgtaaaa gataaaacca 817381 attgttgccg tatactgggt gacagaacgg acaaggcttt caatcgtttt ttcctttttt 817441 tcttcaataa agtccgtccg tttaaaaaat agctgtacca gccggttgat gataaagaca 817501 ccgatccaaa ggataacggc aacgaggaga atatcgacga ttttattttg aaaaatctcc 817561 gtaagtgttt ctttcatccg catctaactc ctggcttgac gttttgtgaa gtctgtatcc 817621 tgataataac tgtttttgac aagaacattc ggtccgaggc accggacatt cgggcagtgg 817681 caactcagtt ctttcgcaag cttggtctct ctccactttt cataggcgga agggaggctg 817741 tccgtctgaa tgttgccaag cggcggggta tcaccgaaat cggtcacgat aatgtttccg 817801 tcgaaaatgt tcacattcag gcgggatcgg ccgtcagggt catttcgcac tgtgacgttt 817861 ttcgccgcgc gaagccggcg aagcagcttt tggtcgtctt cgtccggact gcaggcataa 817921 aacggcagcg ttccgaacag catccacgta ttttcatcac gaatatccag caagcggtga 817981 atggcctgtc tcatctcttt caggctgagg gattcaagag cgcttgcgaa atcgcttgga 818041 tacattgggt ggacctcgtg acgctgacat ttcatatctt ctgtgatttg gcggtgaata 818101 tgctcaatat gcggaagtgt tcgtttgttc agcatcgttt ccgcagatac cattactccg 818161 gcatccacga gcgtgcggct gttttcgatc attttttcaa aatagcgcgc gcgctgttcg 818221 aaggtcggtt ttctgtccat catggcaaag ccgatttcag caaaatcttc aactgttccc 818281 cagttatgtg aaatatgtag cacatcgaga tacggaatga tccattcgta ccgctcgatg 818341 tcgagggtca gatttgaatt aatttgtgtc cgcacacccc gttcatgggc atatttcaat 818401 aaaggaacaa catattcttt tactgatttc aacgaaagca tcggctctcc gcctgtgatg 818461 ctgatggatc tgaggcgcgg gatttcctcc agccgtttta acagaagatc tattggcaga 818521 gcattcgggt ctttaggctg caatgtatag cctacagcac aatgctcgca tctcatattg 818581 cacagtgtcg ttgttgtgaa ttcaacgttt gtcagctgca tgtctccgta ttggtcaaca 818641 tccatatagg cttcccaagg gtcaaactcg ggcgtaatcg gacgcagctt cgtgttttgt 818701 gtcatgacta tctaactcct ttataaatgg gcatactaac gctgccaaca gttaatttta 818761 gacctgattt gccaagatcg caagtagcgc ggcgattgaa aaacggcaaa aaatgagcta 818821 ccataataaa aaatgaatgg aggaacagaa tggggaacgc cgtaaacaat aaagatcagc 818881 agattgatta tttaaagaac agacttgaca tgtttatgaa cgtcatcgat tcattagacc 818941 ctgaagcaac cgacgttgaa gatatagaca ggcttatcag catgcttgat gacctggaag 819001 ccaaatacga acgttttaaa aaagattggg aataaaaccg cgtgcccgcc gcggtttttt 819061 tattggcata aagcaacagt ataaaacaaa gtctctatct gtaaaataag aaaaaatgca 819121 gaaggagcgc tggccatgaa gtggatgtgt tcaatatgct gcgccgccgt attgcttgcc 819181 ggaggtgcag cacaggcgga agcggtgccg aatgagccga ttaattgggg ctttaaacga 819241 agtgtcaatc atcagccgcc agatgccggg aagcagctga acagtttaat tgaaaaatat 819301 gacgcgtttt atttagggaa tacaaaggaa aaaacgattt acttaacgtt tgataacgga 819361 tatgaaaatg gctatacgcc aaaagtgctt gatgtcttaa aaaaacatcg cgtaacagga 819421 acgttttttg tcaccgggca tttcgtaaag gaccagcctc agctgatcaa acgaatgtca 819481 gatgagggcc atattatcgg caatcattcc tttcaccatc cggatttaac gacaaaaaca 819541 gctgatcaga ttcaggatga acttgattca gtcaacgaag aggtttataa aattacggga 819601 aagcaggaca acctgtattt gcgtccgccg cgcggcgtgt tcagtgagta cgtactgaaa 819661 gaaacgaaac gcctcggcta tcaaaccgtt ttctggtcgg tcgcttttgt tgattggaaa 819721 atcaacaacc aaaagggaaa gaaatatgcc tacgatcata tgatcaagca ggcgcacccg 819781 ggagccattt acctgcttca caccgtatcg agggacaatg cagaagcgct ggatgacgcg 819841 attacagatc tgaaaaaaca gggctacact tttaaaagca ttgatgatct gatgtttgag 819901 aaagaaatga ggctgccgtc tttgtaaaag agaaagacct ctccttaaac ggagaggctt 819961 ttctttattt tatacattta atcagtgcgg cccagtccag atccccgaag cctttctcaa 820021 tcccgctttc aaaatggctc ttggccagct cggcaagagg aagatttgca gaaacccgtt 820081 ttgcggcggc gagtgccagg ttggtatcct tcagccctaa agacattttg aagccggccg 820141 gctcaaattt ctgctcggcc ataatggttc cgtaattttg atagactgga gaaccaaaga 820201 gcgcgctggc gatttctaaa aattgttttt gttctaagcc gtatttctcc atcattaaaa 820261 aggattcaga taacgcctcc agcatggaca caagcaagaa attaatgctg attttggctg 820321 catttgccgt cttgctttct tcgccgacgt caaatatctg ctggctcagg ctgtcgagca 820381 gaggcttggc agcttgcttt gcttccgccg gtccggctgt tatgatacgg agcgcggctt 820441 tggctgcggc atccggtctg ccaaggacag gagcggcgag aaaaaattgt cctttctctg 820501 catgagccgc tgcgagcttt tctgagaact caacactgat tgtgctcatc gagatgtgta 820561 tgccgttctc tgctaatcct tcaagcagcc cgtcttctcc gaatgtcacg gtgctgacag 820621 aatcatcatc tgcaagcatt gtgatgacaa tatcagcgga ctttgccgcc agccgcggcg 820681 tatcagctgc ctgtgcgcct tctgtgacaa ggtcttctgt cttttgtttc gtccggttat 820741 agacagtcaa ttcgtagcct gcttgaagaa catttcgggc aatgggctgt cccatattgc 820801 cgagtccgat gacagcaatt ttcaatctaa tcactccctg aatatttttt ccattataaa 820861 caatatgaac agaatatgca tagcgatcgg cttacaacaa aaaagaacag ctgctcgctg 820921 tcctcattta aaaatattga accatccttt atgtacaaac caaatcagca ttccaatcac 820981 aagcgcggcc atcaggccaa gtacagcgaa atatccgtat ttccaatgca gctccggcat 821041 aaagtcgaag ttcataccgt atacaccggc aataaaggtg agcgggatga aaatggttga 821101 tacgatcgtc agtgtcatca taatcgcatt catccggttt gagtttagcg tcacgtagct 821161 gtcacgcaag tcggacgtca tgtcacggtt ggattccaca atttcagaca actttaacaa 821221 atgatcatat atgtcgctga aataggcttt cgtttcccgc tgctctttca catggtcaag 821281 gcttaaaatc cggtagagca aatcacgcat cgggataatc gtccgtctca aatgcaatag 821341 gtctgttctg agatcaaaca cctcgttcat cagcgttcca tacgttttgt ggggacggct 821401 ttcttcaatt tcattcagcc ggtcttcaat tttatacacg agaggaaaat attcatcaac 821461 aagctgatcc atgatcatat aagaaatatg cccgggccct tttttcaata tgtccggtga 821521 agcatacaaa cgctcccgga ctttagcgat accgggcgtt tcgtgtaaat gaaaggtgac 821581 gacaaatttt tcgccttgaa agatatcgac ttcctccgtc tcaagtgttt ccttattcag 821641 cgcatgaatc acgtaaaaac gatagccgtc ataatggtca agctttggcc gctgcatatg 821701 ctggaagcaa tcctcaatgg caagcgggtg aaaatgaaaa aaatctctca ataacgccgt 821761 ttccgtatcc tccgggccgt aaaaatcaac ccagtaccat gcaatatcag gctgttccac 821821 tcgttcgatc ggtatatttt tcagcagctg atgctctgtt gtgattgcgg taatgttgat 821881 cataaacaac cctccacctg ccattatatc atgcggtctt tatgagaaaa gtatacggta 821941 ctctctgcct aattccagcg gcatgttata ctgaacaaaa acggaaaaaa gggtggatct 822001 catgtggaag gaaaaagtat ctgtcacgcc tccgtatcat tttgaccgcg tgctggacag 822061 gctgtcttta gaccccctca atgctgttga tcgagaggcg agggaagtcc gtgtgccaat 822121 cagaaatcaa gcgggggacg tatgtattgt aaaggtacag gcgttaggcc atgcgggcga 822181 gcctgagttc ctcgtcagcg gggaaacgga tcagggagaa atgatgaagg aaatcaagcg 822241 gatttttcaa tgggaaaatc atttgcagca cgttctggat catttttcaa aaacgagcct 822301 gtccgccatt tttgaagagc atgccgggac gccgcttgtt ctggactaca gcgtgtacaa 822361 ctgcatgatg aaatgcatta tccaccagca gcttaatctt tccttcgctt acacgctaac 822421 agaacggttt gttcatgcgt ttggcgagca gaaggatggc gtgtggtgct atccaaagcc 822481 ggaaacgatt gcggaactcg attatcagga tctgcgtgat ctgcaattca gcatgagaaa 822541 agcggaatac accattgata catcaaggat gatcgcagaa ggcacactca gcttgtcaga 822601 gctgccgcat atggcggatg aagacattat gaagaaactg atcaaaatca ggggtatcgg 822661 cccgtggacc gtgcaaaacg tcctcatgtt cggacttggc cgtcccaatt tattcccgct 822721 tgccgatatc ggcctccaga atgccatcaa acgccacttt cagctggacg ataagccggc 822781 aaaggatgtc atgctggcga tgagcaagga gtgggagcct tatttaagct atgcgtcttt 822841 gtatttgtgg aggagtatag aataattcgt ctgacaatga aggaaatcct gcaaacgtgt 822901 tatactagaa agatgtgaaa aaaccatttc actttctgcc atccgcagaa agcttcatat 822961 agaaacggag agaacaacgt gaaccaacaa aagaaacagg cgcccgtcga actgaaggtc 823021 ggacaaactt ttccgctgac gattaagcgt ctcggcatta acggagaagg tgttggctat 823081 tttaagaaaa aagtcgtctt cgtgcccggc gcgcttcctg gcgaagaagt tgttgtgcag 823141 gccacaaagg tccagccgaa gttttcggag ggccgcatta agaaaatccg caaggcatct 823201 gagcaccggg tggcaccgcc ttgccctgtt tatgaacaat gcggcggctg tcagcttcag 823261 caccttgcat acagccagca gcttcgggaa aaacgtgata tcgtcattca gtctcttgaa 823321 cgccatacga agtttaaagt tgaaaacatg gaaatcaaag aaacgattgg catggacaac 823381 ccgtggaatt accgcaataa aagccaattc cagatcgggc gctcgcaaag cggcagcatc 823441 atcgccggct tatacggcct tgattctcat gatatcgtgc cgattaaaga ctgtatcgtt 823501 cagcatccgg caacgaacaa aacaacaggc atcgtccgcc gcattttaga ggacttcaat 823561 gtgtctgttt ataatgaaag aaaacgaaaa ggcgacgttc gcacgatcgt gacgagagtc 823621 ggctttgaaa caggcgaagt gcaggtcgtg cttgtaaccg caaaagaaac gcttccgcac 823681 aaggaagaaa tcgtcaaagc gattcaaaag cgattgccag aggtcaaatc cattattcag 823741 aatgtaaacg gggcgaaaac ctcagtgatt tttggtgaga aaacaaaaca gctcgccgga 823801 aaaacagtga ttcaagaagt gctcggcgac gtatcttttg aattgagcgc ccgcgctttc 823861 ttccagctca atccggaaca gaccgtcaag ctgtatgatg aagtgaaaaa agcggcgcag 823921 ctgaccggaa aagaaaaagt cgttgatgcg tattgcggcg tcggcactat cggcatgtgg 823981 gttgcggacg gagcgaagga agtccgcggc atggacgtca tcaaggaatc aattgacgat 824041 gctaagaaaa acgccaaaaa acacggcatg gcaaatgcca catacgtaac aggaacagcc 824101 gagcactggc tcccgaaatg gacgaaagaa ggcttccgcc cggacgtcgt cattgtagac 824161 ccgccaagaa cgggctgtga cagcacgttc ttggacacga tcaaaaaagt caaaccgaaa 824221 cgctttgtct acgtttcctg caatccatcc acgcttgcga aagatttgca gacgctgtcg 824281 aaggactatc gcgtggacta tattcagcct gtcgatatgt ttccgcagac ggcgcatgtt 824341 gaagcagtgg cgaggcttgt attaaaatcg tctaactaaa aagaacattt cccagtcata 824401 aaatagtttt cctaataaga cctggatttc ggtaaaataa acaattccga tttccgggtc 824461 tttttcgtgc gcagctcttg tcctaacggt ctgttctcaa ttttatcttc cttcttttcg 824521 cggagatctt tattttaact ggcgaaaaga attgaaaaaa cgtgttgaaa agcaggtgaa 824581 aaaaagcgtt atttaaccgg aaaaatatcc tcccagtatg tttaaaatac atgagtagaa 824641 tgatgtaaaa tcatagatgt attttcataa tttgtaaaat tatatattga cttgcagtta 824701 ttacgtgtga aatattgatg ataggaatat aaggaaagta tggcgtatat catttcaaga 824761 gtcattcgat gtaaaaagtt gaaacattgt aataaatgaa agaggtgaaa atgatggcca 824821 accccatttt aaaatgcata acgtatgagc actacaacaa ttaaataata gtgccgagac 824881 gataacaact attacagtaa tacctacaat ggttatatcc ttgcgacaat catgcttcat 824941 aatataatga ttttagattg acacttggct aaaaagtatt gcagagaagg aaatggataa 825001 ttaaatggat aaagtatata aaagaagttg gtttcaaaca tttttggcat ttttagtatc 825061 tcagctttat tttaattttg tagaattaac gggatggggt cctaagtata gagaaatgaa 825121 tggattccca gcaaacatag ttgaactaga tttctttcaa acatatcttt cattctatga 825181 taatccatgg tttaatatta ttactgtttt cttgggagtt ttcactatta tacaaataat 825241 tacagggata acaaaggata ttcgaaatta aagcaataac ttctgatgcc ttatttaatg 825301 atgaaagaaa atgtacactt tcttaattat cttatgagtg aagactgcga cacttagtca 825361 gcagtctatt ttatggttct ggatcaggat taccgaatta taaccctata caaatatata 825421 gtaggttgcc acttgctgcg ttggttattt tctaaatcat gagcaaatcc caaatgattc 825481 agattgaagt tcttgaattc ttttaaataa gggtttattt tctcttctca tcctctttac 825541 tccatgtgat tcacaagtgg tagcagctta agtaggtttt ttcattctct tgagtactca 825601 gttataccac ccccaactca atttgcttta tctctattag tttttccgca aatatgatat 825661 agagatacgg atatggtgta gtgttaaata tcttatcttc aataacaggg caattatttt 825721 gcgttggtaa tatggagaac tcatatgata ttctatttag gttggaatcc tttttatcca 825781 aaaagttcaa aagcaaggcc actaagaaag acgaaggtca gcgccagtta accagaatat 825841 aaaaaatagg gtagataatc atcccacgtg aaatcttcaa aatttactat agattgataa 825901 gaaatgcttt cgcatgcgat aagtgtaaaa gaagcatggt cagtttttaa tttgggataa 825961 aggttcagcc gtatcccata atgaaaggat ttgatttttg ttatgacaga aaatttctgg 826021 cgtgaattac cacggccgtt ttttgtactg gcaccaatgg aagatgtgac agatgttgtt 826081 ttccggcatg tagtaagtga agcaggcaga ccggatgtgt tttttacaga gttcacaaac 826141 tcagagagct attgccaccc ggatgggaag gatagcgtgc gcggccgttt gacttttaca 826201 gaggatgaac agccaattgt ggcccatata tggggagata agcctgaaaa cttccgtaaa 826261 atgagtattg gcatggcaga gttaggattt aaaggactag atatcaatat gggctgccct 826321 gtgcctaatg tggcggggaa tggaaaggga agcggcctta tttgccgtcc tgcagttgcg 826381 gcagaattaa tacaagctgc aaaagcaggg ggattgcctg taagcgtgaa gacaagactt 826441 ggatacacgg atgtggatga atggcgcgag tggctgacac acattttgaa acaggatatt 826501 gcgaatcttt ctattcatct gcgtacaagg gcagaaatga gcaaagtaga tgcgcattgg 826561 gagctcatcc cagagattaa gaaacttcgt gacgaggtgg caccagatac attgctaaca 826621 ataaacgggg atattcctga ccgtcaaact ggcttgaaac ttgctgaaca atacggcgtc 826681 gatggaatta tgatagggcg cggtattttt acaaatcctt tcgcttttga aaaggagccg 826741 aaagagcata gcagcaagga attgcttgat ctcttaaggc tgcatctgga tctccatgat 826801 gaatattcaa aagaagaagc ccgtccatac aagcctcttc ctcgcttttt caagatttat 826861 ctccgcggat tccgaggggc aagtgaatta agaaatcaat gcatgaacac aaagtcaaca 826921 gatgaagtgc gtgcattgct cgacgacttt gagagaaagt atcttgatgg gatagagtaa 826981 cagcagtgct tgattcaaaa aaggctaaca aaataaaggg atttttacac aattcttgac 827041 taaaataaac ctggattttc ggtaaatccg ggtctttttt gtacgcagct tttactcagc 827101 ctgtcttttc tctaatttat tgtaagaaaa taatggtata tttagtggag atatcatata 827161 aagggggaga ggaaaatgaa acggctatgc atcatcccct gcggcaagaa aaaaatctgg 827221 gatgtccagc ctgatgccgg gccggtaaga gcagaggacg cttatctcag cccgtttcat 827281 caggcgtgcg agcggtatgc aaaaacattt ttcgatgagt gggtgatttt gtcggcgaag 827341 cacgggttcc tccgccctga tgatctcgtt tcgggaaatt acgatgtcac ttttggcacc 827401 ggtcatccgg aaatcatgac agcggacgag ctgcgccgtc aatttcacga aaaaggcttt 827461 tctgatatcg aagagctagt catgcttggc ggaaaaaaat atcgaagcgt tctaaacgcc 827521 gtcatcggag aacaccagca tatcagctgg ccgctatcat catacaaagg cataggctat 827581 atgctccaag cgctgaaccg ggctgttgaa gaaaagcatg aactgtagca cgtacatatg 827641 aggaaaagag tgggaacatg aaaaaacttg tgtttggctt gcttgccatt gtgttattcg 827701 gatgcggact atatatctat catgtatggt tcggtgatcc attttcgaaa aatgctgcag 827761 aacagaagct agtgtcttat gtgaaacaaa cctatcctaa gaaagaaatc aagatcacga 827821 atggggtata taacgctaaa acgtctgaat atgtatttga agcaacctcc caatctcatc 827881 gctacccaat gtgtacgaag ggatttctgc atcctaaagt aacgtgcgat ggaattgaag 827941 aagcgtatac cgaatcagta gcaaaacatg taaatgaaga agcaacgaag gcaatcgaag 828001 cagatctgaa aaaagcggtt cctcgattta taaaagctga tgctgctttg agtatcgaaa 828061 acggacagtt cacgttagat acaaaatgga acaaaaagct ggctgaaaaa gcgcctatga 828121 gcatgacgat tcagttagac gccagcgggt tatcaaaaac agatgccgca aagatggcgg 828181 aaacggtcag aaaaacgctt aatgaaaagg gatatacata ctcaaacggc acgatagact 828241 gtatgcagaa ggacggggac ggcggtattg gatatgtcaa atattcaatt gattttcttt 828301 caaaagcagc tattcagtca aacgatgcag aggaactagg aagttaaaaa gatttccaag 828361 gaaataaata cgtcgatcat tgtcaaaggc cgggtgatat ccggtctttt ttttgcatgc 828421 tgtaaaacga gacaaatgaa tcagtttgag acaaaacgag acacacgtct caaactgtct 828481 ccaaagtgaa gatgagaaga ctgattttac gggctcaaaa gactggcaca cttcttgcat 828541 ttataatggt gaaccctaaa tagaaggagg cgcacaaaat gaaattgtta aaacgagaag 828601 gcttgtcatt aactgaggaa aaagcgctgt ggatgtacca aaagatgctg gagatcaggg 828661 gctttgaaga caaagtgcat gaactgttcg cccagggagt gcttcccgga ttcgttcatt 828721 tatatgccgg tgaggaagcc gtggctgtag gggtgtgcgc tcatttacat gatggcgaca 828781 gcattacaag cacccacagg ggacatggac attgtatcgc caaaggctgt gacctggacg 828841 gcatgatggc ggaaattttc gggaaagcga ccggattgtg caaaggcaag ggcggttcta 828901 tgcacattgc ggatcttgat aaaggcatgt taggcgcaaa tggaatcgtc gggggcggct 828961 ttacgctcgc atgcggatca gcgctcacgg ctaaatataa acagactaaa aatgtaagcg 829021 tttgcttttt cggggacggg gcaaataacc aaggtacctt ccacgaaggg ctgaatttag 829081 cggctgtatg gaaccttcct gtcgtatttg ttgctgaaaa caacggctat ggcgaagcta 829141 ccccatttga gtacgcatca gcctgtgatt caatcgccga tcgggcggct gcttataaca 829201 tgccgggggt tacagttgac ggcaaagata ttttagcagt ttaccaggca gccgaggaag 829261 cgatagaaag agcaagaaac ggcggcggcc cgtctttgat tgaatgtatg acctacagaa 829321 actacggcca tttcgaagga gatgcccaaa cctataaaac gaaggatgaa agagttgagc 829381 accttgaaga aaaagatgcc attcaaggtt ttaaaaacta ccttttaaaa gaaacagatg 829441 ctaataagct gtcagacatt gaacagcgtg tcagcgaatc gattgaaaaa gccgtctcgt 829501 tcagcgaaga cagcccatat ccaaaagatt cggagctgct gacagatgtg tatgtgtcat 829561 atgaaaaagg aggaatgtaa gagatggcga gagtcataag catgtcagac gcgatcaatg 829621 aagcaatgaa gcttgcgatg agaaaagacg aaaatgtgct tttgatcggt gaggatgtcg 829681 ccgggggagc ggcggtcgat catttgcagg atgatgaagc atggggcggt gtattagggg 829741 tcacaaaggg actcgtacag gaattcgggc gtacaagagt gctggacact ccgatttctg 829801 aggcaggcta tatgggagcg gctatggctg cggcatcaac cggtttgaga ccgattgccg 829861 agctgatgtt taacgatttt atcggcacgt gctttgatca ggtgatcaac caaggggcga 829921 aattccgtta tatgttcggc ggaaaagcgc aagtgccgat taccgtccgc accacatacg 829981 gagcagggtt ccgggccgct gcccagcatt cacaatcgct gtatggcctt ttcacgagca 830041 tccctggact gaagacagtt gttccatcca atccgtatga tgccaaaggt cttttgcttg 830101 cagcaataga agataatgat ccggtgtttt tctttgaaga caaaacgtcc tacaacatga 830161 agggcgaggt gccggaagat tattatacaa ttcccctcgg aaaagcggat atcaaacgcg 830221 aaggcaatga tgttacgctc tttgcagtcg gcaagcaggt caatactgcg cttgaagcgg 830281 ctgcacagct ttcagagagg ggcatcgaag ccgaggtcct tgatccccgc agtctgtctc 830341 ctctggatga ggatgcgatt ttcacatcgt tagaaaaaac aaaccggctg atcatcattg 830401 atgaagccaa tccgcgatgc agcattgcca cggatattgc tgcgcttgtc gctgacaagg 830461 gctttgattt gcttgatgcg ccgattaaac ggattacagc gccgcataca ccggttccgt 830521 tttcaccagt gcttgaagat caatatttgc cgacaccaga taaaattgtc agcgtcacgc 830581 ttgaattgct tggcgagccg gcattgaatt aaagggggga cacaaatggc ggtaaaagta 830641 gtgatgccaa aattgggaat ggccatgaaa caaggggaag tatcgatatg gaataaaaaa 830701 gtaggcgacc cggttgaaaa gggagaaagc attgccagca ttcaatcgga gaaaattgaa 830761 atggagatcg aagcgcctga aaaaggaacg ctgatcgata tcaaagtgaa agagggagaa 830821 gaggttccgc ccggcacagc tatctgctat atcggggacg ccaatgagtc ggtgcaggaa 830881 gaggcggggg cgcctgttgc tgaagacaat atgccgcaag ccgtccagcc cgtcaaacaa 830941 gaaaacaaac ccgcagcctc caaaaaagat cgaatgaaaa tatctccagt cgccaggaaa 831001 atagcagaaa aagcaggatt agacctaaaa caactgaaag gaactggacc aggcggacga 831061 atcgtgaagg atgacgtaac aaaggctctt gctgaacaga aaaaagatca agcaaagcct 831121 gtttcggagc agaaagcgca ggaaatcccg gtgacaggca tgagaaaggt catcgctgcc 831181 cgaatgcagg aaagcctggc aaacagcgcg cagctgacga tcacgatgaa agctgatatc 831241 accaagcttg ccactcttca aaaacagctt tcaccaactg cggaagagag atacggcaca 831301 aaactgacga tcactcattt tgtctcaaga gccgccgttc tcgctctgca agctcaccct 831361 gtgctgaaca gcttttatca aaatgagcgc atcatcacac atccccatgt gcaccttggt 831421 atggctgtag ccttggaaaa tggcttagtg gtgcctgtca tccgccatgc tgaaaagcta 831481 tcgctgattg aactggctca atccatctca gaaaatgcca aaaaagcacg cgagggacgt 831541 gcgggaagcg aagaactgca aggatctact ttctccatta caaaccttgg cgcgtttgga 831601 gttgagcatt tcacaccgat actaaatccg ccggaaacag gcattctcgg catcggagca 831661 agctatgaca caccggtgta tcaaggggag gagatcgtca gaagcacgat cctgccactc 831721 agcctgacat ttgatcacag agcgtgtgac ggcgcccctg ccgctgcatt cctgaaggcg 831781 atgaaaacat atttggaaga acccgcagca ttaattttat aggaaaagca ggtgaaaacg 831841 acatgacatt agccattatc ggcggcggac ctgcaggcta tgcggctgcg gtttccgcgg 831901 cacagcaggg cagaaacgtg ctgctcattg acaaaggcaa gcttgggggg acctgcctga 831961 atgaaggctg catcccgaca aagtctttgt tagaaagcgc aaacgttctt gataaaatca 832021 agcatgccga cagctttgga atcgaacttc cggcaggtgc gatatcagtc gattggagta 832081 aaatgcaaag ccgaaaacaa caggttgtca gtcagcttgt ccaaggcgtt cagtacctaa 832141 tgaagaaaaa tcaaatacag gttgtaaagg gaacagcctc ctttctttct gaaagaaagc 832201 tcttgatcga aggagaaaac ggaaaagaaa tcagagaggc ggaccaagta ttgattgcct 832261 ccgggtcaga gccaatcgag ctgccttttg ccccatttga cggcgaatgg atcctcgaca 832321 gcaaagacgc gctttctctt tccgagattc cgtcttcact agtcattgtc ggcggcggtg 832381 tcatcgggtg tgagtatgca gggctgttcg ccagattggg atcgcaggtg accatcattg 832441 aaacagcgga ccggctgatc ccggctgaag atgaagatat tgcccgtctc tttcaggaga 832501 aacttgagga agacggtgtc gaagtgcata cttcatccag attagggcgg gtggatcaaa 832561 cggccaaaac ggcaatatgg aaaagcggtc agcgagagtt taaaacgaag gccgattatg 832621 tgctggtggc gatcggcaga aaaccccgtc ttgacggatt gcagctggaa caggccggag 832681 ttgatttttc tccaaagggc attccggtga atgggcacat gcagacgaac gtgcctcata 832741 tttacgcgtg cggagatgct atagggggca ttcagctcgc gcatgccgct ttccatgagg 832801 gcatcatcgc tgcttctcat gcttccggaa gggatgtcaa aatcaatgag aaacatgtgc 832861 cgcgctgcat ctatacgtcc ccggaaatcg cgtgtatcgg aatgacagaa cgacaggcaa 832921 gaagcatata cggggatgtg aagatcggcg aattttcatt ttccgcaaac ggcaaggcgc 832981 tcattaaaca gcaagcggaa ggaaaggtca aaatcatggc tgaaccggaa ttcggcgaaa 833041 tcgtgggtgt ctcgatgatt ggcccggatg taaccgagct catcggccaa gcggcagcga 833101 tcatgaatgg tgagatgacg gcagatatgg cggagcattt tatcgccgcc catccgactt 833161 tatcggaaac attgcatgag gcgctgttaa gcacgatcgg ccttgcggta catgcataat 833221 aaaggaaaaa gcaggcgcat ggatataagg cgcctgcttt tttattgttg aaagcgcttt 833281 atttttcccc tacaatagat gaaaacggcg tgtaagggag gagcgatcaa ggaaatgaat 833341 tcggtcccaa acgatttgca aacctggaaa cgttttgtga aagacggtgt gcttgacgaa 833401 gcccgattaa gaaaacggat tgcagagtca tggcatcgct gcaaaaaagc tgaggtcaat 833461 ccttatttag aaaaaggccc gaaggtttta cagcaaacgg agctggatca gcagtcaaaa 833521 aaacattcat tcttcttgac gaccgcaaag ccttacctcg aaaaactgct gcctgccata 833581 aaagaaatgg aaatgatggc gctgttaatt gattcagacg gtgttgttct ggcattggac 833641 ggccatccgc gcgcgctcta tgaagccaaa cgcatcaatt tcgtcgaagg ggcatgctgg 833701 acagaaacgg ctgtcggaac aaatgcgatt ggcacggcgc tccacatcag cgagccggtt 833761 gcaatacaag gatcagagca ttactctatc gcttcccatc tttggaactg ttcagctgct 833821 ccgattcacc atgaggatgg cagccttgcg ggtgtaattg acatatcatg cccggcggca 833881 ggcgcgcatc ctcatatgct tggtattgcc acggcgattg cctatgccgc tgaacgggaa 833941 ctcgcagcta aaagccgtga gaaagagctg gagctgatca gccgttttgg ggagagagct 834001 gcatccagtg tgccgatggt gctctgtaat accaagcagc acatcatcag tgcgagcatg 834061 ccgattcgaa cctcaatgcc ggattggcag ggccggcacc tgtacgagtt gaaggaacgg 834121 ggctattcaa tcgaaaatgc tgtcaccata ggagatggcg gcacttgttt ttatctttcg 834181 gaacaaaaga aaaagaaggc gtttcgattc aatggagtga tcgggcaaag cggccgatcg 834241 caagcgatgc tgatgcacct tgaacgagca gctgcgacgg atgcatcggt ctgtttgtcg 834301 ggtgaaacgg gtacggggaa ggaggtcgcg gctcgcgcgc ttcatgagaa cagtgagaga 834361 cggcacggtc cgtttgttgc tgtcaattgc ggagcgattc cgtctgattt gattgaaagc 834421 gaactgttcg gatatgcaga gggcgctttt acgggagcga aacgaaatgg ctataaaggc 834481 gcctttcaaa aagcgaatca aggcacatta tttttagatg aaatcggaga aatttcccac 834541 tcgatgcagg ttgcactttt acgggtgctt caggaacgca agataacgcc aatcggcggg 834601 acgaaagaaa ttccggttga tatcagagtt attgccgcca cacattgtga tttacgcgag 834661 cttgccgaaa acggaaaaat cagagaggac ttgttttacc gtcttcatgt ctatccaatt 834721 gaactccctc cattacgcga tcgcaccgag gatatcccgg atctctttga gtactacaaa 834781 cagaagaatc attggccagg cgatcttcct tctgattttt gtaatgtgct gaagcaatgg 834841 aagtggccgg ggaatatccg cgagctgttt aatgtgtttg aacgtctttc tatcagattt 834901 ccggacggcc ggctgagaga tgaatcgctt cccgctttac tggaagccgc tggattgccg 834961 gccagctctg cagaaaaaaa gccggctgct gccggcgtgc ttacttttcg tgagcaaatc 835021 caaaaggata tgatgatcaa agcgcttgaa tctgcaaaag gaaacgtctc tcaagccgca 835081 aaaatcagcg ggatcccccg aagcactttc tacaaacgcc tgaaaaaatt caacttgtcc 835141 gctgaatcat aaagcatact tccttcagga aatggaaacg ttatgtattg aaggagggtg 835201 ttacgatgaa tattcaaagg gcgaaagaaa ttgtagaatc tcccgacatg aagaaagtaa 835261 catataacgg cgttcctatt tacattcagc acgtaaatga agaaactgga acagcaagaa 835321 tttatccgct tgacgaaccg caagaggagc atgaagtgca gctgaacagc ttaaaagagg 835381 attaaacaaa aatggcccgc ttcataagca ggccattttg ttatccgcgc ggcgcaaata 835441 aaataacaca gacaccgatg agacaaatga atgcgccgat ccagtcatac agatcaggtg 835501 ttttccggtc aacaagccat ccccacagga ccgcaagcac gatgaatact ccgccataag 835561 cggcgtatac acggccgaaa gatgggaagg actgaaacgt cggaagaatg ccgtatacaa 835621 tgaggatcag cgccccggcg attccgtagc cagctggctt tgcctctctc agccatagcc 835681 aaaccagata tccgccgcca atttcagcaa gccctgccgc gagaaataaa agaatggtaa 835741 tcagcatcat gagcactcct caatttgcat ttatctttca ttatagagga ggagagcttt 835801 taaagcttcg gatgattctc aaattccttc aaatacgctt ttcgctgaac ctctgtaaat 835861 tggctgatcc aattgttttg agcctcttca ttcaaatggg gaaggatata gcgttcaacc 835921 gcttcgaaaa acagcggatt cgtgatgatg ttccaggtcg ggattcgaac gattttgccg 835981 tctgttttct cgatgataat atcctcaaaa aagatccctt tcaaactgta ttgatggcgt 836041 cccatataaa gccgcttcac ctcggaaaac agcacgctgc gctttctcaa gaagatttcg 836101 ccactaggtc cggtctttat ggtgaaaatg acatttccac ggcttgtgaa cgcaggaaaa 836161 gccataaaga atgtgatcaa tccataaatc atcgccagta atccgccgcc caaataaagc 836221 agggcatatt tagattcaaa cgtgagggct tcagacacca gccagactcc cacaataaag 836281 gcgccccctg tagcgaggaa cagccaagcc cttagaaaca tcatgctttt tacttcaatc 836341 atgtgctgcc cctaaagctt cggatgattc tcaaattcct tcaaatacgc actgcgttgg 836401 atgtctgtaa actgtccgat ccaattgctt ttcgcctctt cattcagatg tggaaggata 836461 tagcgttcaa ccgcttcgaa aaacaacgga ttcggaatga tgttccaagt gggaatgcga 836521 atggtcttct gatccacggt ttggatcaat atatcttctt ggaagattcc ttttagacta 836581 aatttatggc ggctcatctc aattttcttg atatcagtaa acgtaacaga cactttgtca 836641 gtgaacactt ctccattttt tcctgtcttg atgcggaaaa tggtatttcc ccgcggggtg 836701 aaagccggaa agaagatgat aaataaatat aaacaaaaca aggtgaacag aaagccagca 836761 ggaatggcta ataggtaata tttcgtttga aacgtaatac ccatataaaa gagccacaaa 836821 catgctaatc ccataccggc agatccgaca aaagcccata ttctcaggaa cattttgctt 836881 ttgacttcaa tgatttcttg gtttttcaat gcttttctcc ttttgttaat tcaattctta 836941 tcattttgaa atgatttgat ttacaacatc cttatgagca gggaggatag aaaattcatt 837001 ctgggtgatg cctgtgacaa gccaagtatg gtgggccccc ggcaggacga atgccatgtc 837061 agccacttca ggagtgttat cttttccata tgccagacgc ataagtgtat ccattttccc 837121 tttccgcaaa gccagatcat ttgcaaatcg ggtaacgtcc tcttggtggt catgtttttc 837181 aaggaactct tttagatatg aagggttgtc tgaagcgccc tccaagagtt tttcaaattc 837241 atttgatgtc aatgttacaa tcgattctct tttatcctct gtatctatta tatgtaaaaa 837301 ctcatctgtc ttagcaagta acccttcact tgattccatt tttgtaatgc gatggacttg 837361 ttcatcaaaa aggagttcgt gagagtaggt gccgaatttt gatacatggc atgacacatt 837421 ctgttcggca ccttgcccgt taaatttaga aagcttcact gtatagtcag cgtcgtttaa 837481 tacatggata aacggacagt actcgtcctt taaccgatat tgatggttcc gatattccgc 837541 tgcatccttg gctaagagtg agcggcacgc ggcttcaaat aaggcgccga gctgttcatc 837601 ttctatttcc ggaaaatagg cctgcttcaa ggccattccc tgttcaaaaa acccttcgct 837661 gtaaaagcaa aacaagagtt cttctatgct aattgtaaac tgcttcattg tttattctcc 837721 tatccaaatg aaaatttccc tttaaggaaa tgggttgcgc cgtgtataag cgaatccgct 837781 gttttctttg ctttttccat tccttttttc gcgctgtcta tccctttatg tatcgattta 837841 ttcgccgcat ctatgccgtc attcactgat ttgacgactt tgccggctga ttccagccct 837901 tttttggctg tatcaacaac agcatggatc ggttctttca gctttaaggc tgctttttca 837961 gcaaaaccgg ctgtatattt ggcgatttgt tctccgacga ctccgccaat gtatgaacct 838021 gctgccccaa gaaggacagt acccacaggt cctgcaaagc ttccgattgc accgccgatg 838081 acagcaccag ctgtggcacc gccggcaaca aaaatcgtat tattcacagc attcccgacg 838141 gccttggcgt tttcacgctt gagaacttcc ggtttatcct ggtattttgc ataattttca 838201 gcaattttca cgcctgctcc gaatgtttcg gtcgctccgg taatcagtgt ggcggtaatg 838261 gcatttcctt tcgcgaatct caagcccgtt tttcccacat ccttcaaagt ggagcgtacg 838321 ccggcttcat taagaaatcc ttttgtgtag cttctgacgc tgtttgaaaa atccaccgtg 838381 tcctgaggaa agtattttgt aaacttttta tgtaccaaat ctgaaaatgg acggtttgtc 838441 tttttcaaca aatatttagg attcaaaagc actcttgccg ctttttgata acgtgagctg 838501 tcaacggccc tggaaatatc caagagcagt tttgagtgct gggctgtatg caagccgctt 838561 ggttgtttca caaatttcgt aagccctaat ccgtaatatt ttccctgcgt cagcataaga 838621 gcggttaagc ttgtcatcgt accgtatttg tcgtaggcat tgtagagctt tcgcaaaata 838681 tcatcttgtt ccacaaattt atcgcctgtt tttctgatga aaatctcatt gtcactcagc 838741 ttagtgacga gcgcctttcc tgagctccac gcatcgccca ctccagaaaa acagctgctg 838801 tagcggggat cgcattgcaa aatcatctgc cccagctcca catgcaggtc cttatatttg 838861 ttttccatat cagttaattc agtgactaca tcatttgcaa gctgttcgag cttatccgga 838921 tcaactgcaa tgtttcctga cacaccgttc acctcccgag tttatgtctt tcctctcttg 838981 ctttacgctc cagttcttcc attctggcaa tttcagcttt tcgttcttct attttgacag 839041 cggcagcctt cagctcttgg cttgtttcaa gcagctcctg ttcgaattga tcgtaggcgg 839101 ctttcgtttc ctcgaaatcc tggtcaaacg aatctcttgc tttgccctgc caagcatctc 839161 ccaatgcaga taaccgggat tcaagcagca ttttggagct tctgacctct tctgcggccg 839221 cactatactt gtttgccagc tcaatgactt tatatgagtc caacttttgt cccctgcctt 839281 ttctaaattc acgcacaatt ggatgtttta tataaatgat tataaataat tcggcatgta 839341 tccgaatcgt acaaaagaac cttttcataa gaattggaag ggcgtatatt cacttaaaat 839401 tcacagttgg tgagacttta agattacaaa aaaggtaaaa aaaccaaatc tctcagacat 839461 aaggcaaatg agaaatttcc cgctctatgg gaaaaaacac taaagttgat caaatgacct 839521 aagtgcgcca aacgtgttac gggacgagct atctcatggt ataaatggaa ttgtaaacgt 839581 tatcaaggag gtcgtcatat gaagaaaaaa tcattctcaa tcgtaatagc gggcggaggg 839641 agcactttca ctccagggat cgtactcatg ctcttggacc atttggagga gtttccgatc 839701 agaaagctga agctgtatga taatgataag gagagacagg atcgaattgc aggcgcctgt 839761 gacgttttta tcagagaaaa agcgccggat attgaatttg cagcgacgac tgacccggaa 839821 gaagctttta cagatgtcga ttttgttatg gcgcacatca gagtagggaa atacgcgatg 839881 cgcgcgcttg atgagcaaat tccgttaaag tacggagttg tcggccagga gacgtgcggg 839941 ccgggcggga tcgcatacgg tatgcgttcg atcggcggtg tgcttgaaat attagattac 840001 atggaaaaat actcgcctga tgcgtggatg ctcaattatt ccaatccggc ggcaattgtg 840061 gctgaagcta cgagacgcct tagaccgaat tctaaaattc tcaatatctg tgatatgccg 840121 gttgggatcg aagaccggat ggcgcaaatt cttggcttat cctcaagaaa agaaatgaag 840181 gtccgctatt acggattgaa tcatttcggc tggtggacat cgattcagga tcaagagggc 840241 aacgatttaa tgccgaagct gaaggaacat gtatcccaat acggttatat tccgaaaaca 840301 gaggctgaag ctgtggaggc aagctggaat gacacgttcg ccaaagcgcg tgacgtgcag 840361 gctgcagatc ctgacacact gccgaatacg tatttgcaat attatttgtt cccagatgat 840421 atggtgaaaa aatcaaatcc gaatcatacg cgggcgaatg aagtcatgga agggcgcgaa 840481 gcttttattt tcagccaatg tgacatgatc acacgtgaac agtcctcgga aaacagcgaa 840541 attaaaatcg atgaccacgc atcgtatatc gttgatcttg cccgggcgat tgcctacaac 840601 acaggtgaaa gaatgctgtt gattgttgaa aataacggtg caattgcgaa ctttgacccg 840661 actgcgatgg ttgaggtgcc atgcatcgtc ggctcaaatg gacctgaacc gattaccgtt 840721 ggcaccattc cgcaattcca gaaagggctc atggagcagc aggtatccgt tgagaagctg 840781 actgttgaag cgtgggcaga gaaatcgttc caaaagctgt ggcaggcgct gatcctgtca 840841 aaaacagtgc cgaacgcgcg tgtggcaaga ctcattcttg aggatttagt ggaggccaac 840901 aaagacttct ggcctgagct tgatcaaagc ccaacccgca tatcataaat gaaattcccc 840961 cattttcgaa tctgtaattg tatataatag aaagaaaatg gggggatctg atatgcagct 841021 cgaagaactg atcaatcagc actacagcaa attgaatgac aacgattttc atattttaaa 841081 atatatattg aatcataagc acacatgcta tcaccttgga atcgacgcgc tggccaaagc 841141 ttgcagtgta tcgcgttcct caattttacg gcttgcccaa aagctcggtt tcagcggtta 841201 cagtgaattt cgcgtctttt taaagtggga agatcagccg gaagaaggcg agagtatgag 841261 ttttgaaaag ctgcttgatg atattgaagc aaatttgaag tttttacgga caaaggacat 841321 gacggacatg tgccagctga ttgatgcagc tgaccgcatt ttcgtctacg gttctggaaa 841381 tgcgcaaaag atatgcgccc gcgacctgca aagaatgttt attccgcgcc atcgctatct 841441 tattttgatt gaagacacaa atgaatttaa tttgatgcgc gatgatttta aagtgaacga 841501 tctgtttatc atcatttctc tttccggaga aacaccggag ctgattcctc aggcaagaat 841561 gctttctgca aagggtattc cctttatttc cattacgaat ttaaaaaaca atgtcctcgc 841621 ccagctgact ccgcataatc tttatgcgac aagcaaacct gtgacattaa gcgatagaac 841681 ggaaattgtc gcttttgcac cgttttttct cgttggcgaa gcattgttcc gcgcatatgt 841741 tgattacaaa gaggcagaaa aaaatgacaa tgagtagcag ggggttctgg tatgatgcaa 841801 aaaattcagc gctttggaag cgcgatgttt gtgcctgttt tattattcgc gttcgccggc 841861 attatcgtcg gtatcagcac gctctttaaa aataaaaccc tcatgggacc gctcgccgat 841921 cctgacggtt tttggtatca gtgctggtat atcattgagc agggcggctg gactgttttt 841981 aaccaaatgc cgctcttatt cgccattggc atcccggttg ctttggcgaa gaaagctcag 842041 gcacgcgcct gtttggaagc gcttactgtc tacctgacat tcaactattt tgtcagcgcg 842101 atattgacgg tatggggagg agcatttggc gtcgacatga atcaagaggt cggcggaacg 842161 agcgggttaa cgatgattgc gggcataaaa acgctcgata ccaacatcat cggagccatc 842221 tttatttctt cgattgtcgt ctttttgcat aatcgctatt ttgataaaaa actgcccgat 842281 tttctcggca tctttcaagg ctcaacatat atcgtgatga tttccttctt tattatgatc 842341 ccaattgcgt tggctgtgtc ttatatttgg ccgatggttc aatcgggaat cggctcgctt 842401 caaagcttcc tggttgcttc tggggcggtg ggcgtttgga tatacacgtt tttggaacgg 842461 attttaattc cgaccggcct tcatcacttt atttacacgc cgtttattta tggcccggct 842521 gtagcggaag gcgggatcgt cacgtattgg gcacagcatc tcggcgaata ttcgcaaagc 842581 gccaaaccgc tgaaggagct ctttccgcaa ggcggattcg cgcttcacgg caactcgaaa 842641 atcttcggta ttccgggtat cgccctggct ttttatgtga cagccaaaaa ggaaaagaaa 842701 aaactcgtcg cagggctgct gattcctgtc acactgacag cgattgtcgc cggtattaca 842761 gagccgattg agtttacgtt cttattcatt tcacctttct tatttgcggt tcacgccgtg 842821 cttgccgcca caatgtcgac agttatgtat atggccggcg tcgtcggaaa tatgggaggc 842881 ggactgattg aggcggtaac cttgaactgg attccgctct ttggcagcca cggtatgaca 842941 tatgtgtatc aaattttgat cgggctctcg tttacagcaa tttatttttt cgtcttcaga 843001 tttttaatcc tcaaattcaa tatcgctaca ccaggacggg aaaaggatga acagcaggaa 843061 acaaagctat attcgaaaaa ggaatacaga gaacgaaaaa acaaggatga aacggcctcc 843121 gctgctgaaa cggctgatga caccgctttt ctgtatattg aagcgctggg cggaaaagac 843181 aacatcactg aagtcacaaa ctgcgccacc cgcctcagag tcagtgtcaa ggatgaaaca 843241 aaggttgaac ccgacagcgt attccgcgcg cttggcgcac acggcgttgt caggaacggg 843301 aaggcgtttc aggtaattat cggattaagc gtgccgcaga tgcgggagcg tgtggaaaaa 843361 atattgaatc aataaagact gccctccttt tcgggagggt tttcgtttgc cgtcaaaaag 843421 accgccatag taaagtaaag aaagagacaa tcgagtaaaa aggggtttgg aggcttttac 843481 atgcaaaagg ctttgtcgtt tttaaaacca tattcattgc tggcgggaat tgctctgatt 843541 cttatgctga cggagcttgc agttgaactg atgcagcctt tattgattgc aaaaatcatc 843601 gacgatggga tattgaagca agatctgcgg catgtatgga tatggggcac ggtcatgatc 843661 gggctgaccg tgttatcctt tgcggcgggg atgctgaatt ccttttatgc cgcccatgtc 843721 agccaaagct tttcctatga tacgagaaaa gggctttttc aaaaaatcca gtccttctcc 843781 tattccacat ttggacagtt ttcgtcctct tcttatatta caaggctgac aaacgacgtc 843841 acacaggttc aaaatatgat ttttatgagt ttgcggttta tgctgcgggc tcccttaatg 843901 attgcaggcg gcattgtgct gtcgcttgcc gttaatgtga aactcgggtt ttttctgctt 843961 gtgaccattc cgatcctgat cttgtttttg ctatgggtat taaggaaagg cggggcactg 844021 ttccgctcag tgcagaaaag gctggatcaa gtgaacacca tcatgcagga aaatttaatt 844081 gcaatcaagc tgatcaaagc gctgcttcgc ggcagccacg aagtcaaacg atttatcaaa 844141 gccaacacaa ggctgatgga aaaaacggtt tcggcctttc agcttgtgga attcacgatg 844201 cctgtactga tgctgctgat gaatctctgc atccttttga ttttgtgggc ggggtcctac 844261 agtattacga gcggaagcac tcaggttggc gatgttgttg cgataattaa ctacgcaaca 844321 cgaattacag gcgcgctttc gatgtttccg tttttgatta tgattttcac ccgggcgaag 844381 gcttcagggg atagaatcgg tgaggtgctt gaaacagaag gcgacgagcg ggaggaaggc 844441 accatatctg atcgtttgtc aggacggatt gagtttcagc atgtatcctt tcgctatcct 844501 gaaatggaca gagaagcgct caggaatgtc tcattttccg caaagccaag agaaacgatc 844561 gcgattctcg gtgcgacggg ctcgggcaag tccacgcttt ttcagctcat tccgcggctt 844621 tatcagccgg attcaggccg catttacata gatgaaaagc cggttcaaga tattccggct 844681 gaagggctgc gcaggcaaat tggatatgta ccgcaggaag tcctcttgtt ttccggcaca 844741 atcaaagaaa acatcgcttg gggcaaagaa aatgcttcac tagatgaaat aatggatgcg 844801 gcaaaacttg cgcaaattca tgaaacgatt ttaaagctcc caaatggata tgacactgtt 844861 ttggggcaaa gaggcgtcaa cctgtccggc ggccaaaagc agcggatttc cattgcgcgg 844921 gcgctgattc gaaaaccggc tatccttcta ttagatgaca gcacaagcgc gcttgatctg 844981 caaacggagg cgaagctgct tgaagcaatc agcacatacc attgcacaac tttgatcatt 845041 acacaaaaaa taaccacggc gatgaaagct gatcagattt tgctgcttga ggacggcgaa 845101 ctgattgaaa aaggcactca cagtgagctg ctttctgaat ctcagttata caagcgcatt 845161 tacgagtcac aattcggaag ggaggggagc gagtcatgct aaaagacatc cgcaagcctt 845221 tccaatatcc caaactgcca attgacaaaa aagaaggcgc gaaaaagcgg gcgaaagcaa 845281 aggatacaaa gggcacactg agacgaatct ggtcttactt ggctgaaaga aaaggactgc 845341 tcatacttgt catgctaatg gttgtcatca gcgccatatt cggactcctt ggtccctttg 845401 tgatcggaaa ggccatcgac cattttatcg tcgggaaaac ggtcagcggc ttgattcctg 845461 ttttgcttct tctgctcgct atctatatca ttcagtccct gtcgctttgg tttcaaaact 845521 attggatgat tacgatctcg cagggcacgg ttttcagaat gagaagcgaa ttgttcaccc 845581 atctgcatga gctgccgatt ccattttttg ataaacagcg gcacggcgag ctgatgagcc 845641 gggtgacgaa tgacatcgaa aatgtcagtt ctaccttaaa cacgtcagtc attcaaattt 845701 tgtcaagtgt gatcaccttt gtcgggacga ttgcggtgat gctgtacatg agcccgctcc 845761 ttactttgat tacgctgacc attattccgg tgatggcagc gagcctgaaa tggatcacca 845821 accgaacggg aaagctgttt aaagaacagc agaaaaacct tggtgatctg aatgggtata 845881 ttgaggaatc tgtttcaggc gcaaaggtca tcaaagcata ttcacgtgag aagcagatta 845941 ctgctgaatt cctcgaaaaa aacgctgcac tcaagacgtc gggcttttgg gcgcagacga 846001 tttccgggtt tattccgaag gtcatgaact ctttgaataa cttaagcttt acaatgattg 846061 cggcaatcgg cggtttgttt gcgctgaaag gctggatctc gatcggctcc atcgttgtct 846121 ttgccgagta ttcaagacaa tttacacgcc ctttaaacga tctggccaac cagtttaata 846181 cgatgctgtc cgcaatcgcc ggcgctgaac gggtgtttga cgtgcttgat gaaaaagaag 846241 agcgcgagga tgaaaagaac gccgtgcatc agcccatcca aacaggcagc attgaattcc 846301 gggatgtgtc cttcggttac gataaagggc agcagacact gaagcattta cagtttaccg 846361 tgcctgcggg gcagtccatc gcgtttgtag gaccgacggg ggcggggaag acaaccgtca 846421 ctaaccttct cgcccgtttt tacgagccta acgatggaaa aattttaatc gatggtacag 846481 atattaaaac ccttactaga gcaagcctaa gaaaaaacat ggggtttgtt cttcaggatt 846541 ctttcttatt tcagggaacg atcagagaaa acattcgcta cggcaggctt gatgcttctg 846601 atcaggaagt cgaagccgct gcaaaaacag cgaatgccca tagttttatt gaaaggctgc 846661 caaaagggta tgacaccgta ctgacgcaaa acggttcggg catcagtcaa gggcagaagc 846721 agttgatttc tatagcgagg gcggtgcttg ccgatccggt tcttctcatt ttggatgaag 846781 cgacaagcaa cattgatacc gttacagaag tcaacattca agaagcgctc gcccgtttaa 846841 tggaaggaag aacaagcgtc atcattgccc acaggctgaa caccattcaa agagcggacc 846901 agattgtggt gctaaaaaac ggtgaaatga ttgaaaaagg cagccatgac gagctgattc 846961 ggcaaaaagg attttacagt gacttatatg aaagccaatt tgagaaatag acctttgtcc 847021 tgcacagagg tctttttttg ttacagtttt atagtacttt tatttcattt tcgtaaaatg 847081 taacaaaatt acttgacgta aacaagttat gtatatatac tagcttacat taagtaagtg 847141 ataacattta tcaaggagga taaaatgaat aaatcatttg aaattggcac attactttta 847201 agagttatta caggtattat cttttttgtt cacggtttat caaagtttca gggaatggag 847261 ggcaccatcc aatttttcgg cagcataggc cttccaagct ttatggcgta tgtcatcgca 847321 gcgattgaac tgattggcgg agtgcttgtc ttcttcggat tggctacacg tattgtcggt 847381 gtactgttcg ctcttacact gatcggcgcc atcatcactg ttaagctgaa agcgccattc 847441 atgggcaatg cagaatttga ttaccttctg cttttgacat ccattcacct ggcgcttact 847501 ggaagtcgat tcctggcgct ggacccattt gtgtttaaag gaaaaaagaa cggaaacgtt 847561 tcagcataag aaaagaggca tgcagcatga ccagcattca tgaggataca cacattggct 847621 atgccaaact cacaattcgc agtctggagc gttcgcttca gttctactgt aacgtcatcg 847681 gttttcaagt cttaaaaaag acggaccgcc aagcggaatt aacggctgac gggaaacgcg 847741 tactgcttat tcttgaagaa aatccgagcg ctgtcgtctt gcctgaacgg tctgtgacag 847801 gcctttatca ctttgcgatt cttcttccgg acaggaaaga acttgggatc gcgctcgccc 847861 gcctgattga acacggcatt gctatcggac atggagacca tgctgtcagc gaagcgctct 847921 acctgtctga tcctgacgga aacggcattg aaatgtacgc tgaccgcccc cgcagcacgt 847981 ggcagcgtga tcgggaagga aactacgtca tgacgacaac cgctgttgac attgagggcc 848041 ttctggaaga ggcaggagat gagcggaaaa catcgcttcc gaacgataca atcatcggac 848101 acattcatct gcatgtcagt gatttgaaag aagcaaaggc gttttataca gatgtactgg 848161 gctttgacat tgtcggaaac tatgcgggca tgtccgccct cttcgtttca gccggggggt 848221 accaccatca tatcggctta aacatttggg cgggaagaaa tgcgccgcct aaaccgacaa 848281 atgccagcgg actagattat tatactgttg tcctgcccca ccaagaggag ctggatttgg 848341 tggcaaaccg agtcaaacat gccgggtatt cgattgaaga gacggaaaac agctttcgtg 848401 tgaaagaccc tgtttccggc gcctatatta catttgtgat ttaactgcaa tccccttgcc 848461 gaaataacgg cagggggatt ttttattttt gtccgccttg ttatgatgag agaaccaact 848521 tgttaggagg cgtttacatg gaactcaacc accttgtgac gggcaaaata gcattaaatc 848581 aatatgtgca tcgcttagag caaaaggatg tttcatttta cgtccactac tggggagcga 848641 tgacgaacca ctataacaca ctgcttcata agcattcctt ttatgaaatt tgttacgtgg 848701 taagaggtga aggatattac cttgaaggcg atcgtacata tccgcttcgt gaacagacga 848761 tttttttgtc aaagccggag catttgcacc aaatcaaaag tgaaacaggg ctgttccttt 848821 tttacgtcgc tttcgagctg agcgaggatc agtcaagcgc cgaatggatc aaagtgatgg 848881 aagaagtgaa acaaagcccc tttatcacaa tgcaattgaa agatggcgaa ccgccgggcc 848941 tgctttggaa aacgttaatg ctgcaagcag cgcaacctgt caatgctttt gacaaagaga 849001 tcctatctca tttgtcgcat gcattgatcc tgtcattaat ccaaaccttt ctcccgtacg 849061 cccaacgccc gaaacaaaag cagcccattc acacatcttc tgctttgctg acagaggtga 849121 aactgcacat aaaagacaat ctgtcacagc cgttaaagct gacggatgtc gctagccact 849181 ttcatatctc agggaggcat ttatcacgtt tatttgcagc agaactgggc gtcagctact 849241 cagaatttgt ccaaaatgaa aaaataaaca aagctgccga actgctgaaa tcaacgaatt 849301 tgtcgattaa agaaatagcg gaagaaatcg gtttctcagt acattatttc actcgcgtct 849361 tttccgctaa aatcggcagc tctccagggc ttttccgctc cctttataaa gactcaaaaa 849421 tgaccgcatt tcaaatcaat aaaccttttc aaaaaatcga acaggccaag ccgcacgaat 849481 aagatgtcct gaaatgacaa aacaatgtct tcatatgata aagacgcgag aaatctcgtt 849541 gtcttataat ctttttagaa agcggttaca acaaggggta ttgctgaagg agggatgcat 849601 tggcttatgc ttggtgtcgg gtgctctgcc attcttgaaa gaaggggaag aaagccgtga 849661 gtacaaaaaa gaaagaggct gtaataggaa aagaaagctt agctcataaa gggcttttac 849721 gaacgattac attggtatct acattcggcg gcctgttgtt cggttatgat acgggtgtca 849781 ttaatggggc acttcctttt atggcaactg caggtcagct gaatcttaca cctgttacag 849841 aaggactggt tgcgagttcc ctgcttctcg gggcagcctt cggggcgatg tttggaggac 849901 gtctgtccga tcggcacggc cgccgaaaaa cgatccttta tttagcctta ctcttcatcg 849961 cagccacact tggctgtacc ttttcaccaa acgcgtccgt gatgattgcc tttcgttttc 850021 tgcttggact ggcggttggc tgcgcttctg taacggttcc aaccttttta gcggaaattt 850081 cgccggcaga acgcagggga cgaatcgtga cacaaaatga actgatgatc gtaattggcc 850141 agcttctggc atacaccttt aacgccatta ttggcagcac aatgggggag agcgcaaatg 850201 tatggcggta tatgctggtc atcgcgacac ttccggctgt tgtgttatgg ttcggaatgc 850261 tcatcgtgcc tgaaagcccg cgctggctgg cagctaaagg cagaatgggt gacgccctgc 850321 gggtgcttcg gcaaatccgt gaagacagtc aggcacagca ggaaataaaa gaaatcaaac 850381 atgcgattga gggcacagca aaaaaggccg gctttcatga ttttcaagag ccgtggataa 850441 ggcgcattct attcattggg attggaatcg ccatcgtaca gcaaattacc ggtgtcaatt 850501 cgattatgta ctatgggaca gaaattctga gagaagccgg ttttcaaaca gaagctgcat 850561 taatcggcaa tattgcaaac ggtgttattt cagttattgc ggtcattttt gggatatggc 850621 ttctcggcaa agtccgtcgc cggcccatgc tgatcatcgg acagattggc acgatgacag 850681 cccttctgct gatcgggatt ttatccattg tccttgaagg aacacccgcc ctgccgtatg 850741 ttgtgctgag tttgaccatt ttgtttcttg cgtttcagca gactgccatt tctacggtga 850801 cgtggctgat gctctcggaa atctttccta tgcatgtgcg ggggcttggc atggggatca 850861 gcaccttctg cttgtggaca gctaactttc tcattggatt cacctttccc attttgctca 850921 atcatattgg gatgtcggcg acatttttta tctttgtcgc tatgaatatc ctagcgattc 850981 tatttgtgaa aaaatatgtg cctgagacaa aagggcggtc acttgaacag cttgagcatt 851041 cctttcgcca gtatggccgc cgcgctgatc aggaaatcca aaatcaaaca actcacttat 851101 cgtaacctga gataccagga ggaatctatc aatgaaacta tcttatgtaa cagacagcct 851161 agggcatttg ccttttgaag acatgctcaa ttttgccgca aagcttggga tcgatacact 851221 tgaaatgaca accgggggct ggtcgccggc acctcacttg aatcttgatg aattgctgca 851281 aagcagcgaa aaaagaaaag aattttcaca agcgctggaa aagcggaaca tgacactttg 851341 cgcattaaac tgctcgggga accctttaga tccgggtgaa ttgggcaaat cgcacagaga 851401 cataactgac aaaacgatgg agctggctgg attattaggc gtcaaaaaag tgatcatgat 851461 gagcggtttg ccagccggcg gcccggacga caaagtgccg aactggatca catacacagt 851521 aagctggcct cccgttttaa aagatatcct caactatcaa tgggaagacg ttgcgatccc 851581 atattggaag aagcttgtca aaaaagcgga ggcctgcggc gtggggaaaa tagcgcttga 851641 gaacttcagc tctcaattag tctataatcc tgagactctc tttcggctca gaaatgcagt 851701 cggcccgatg gtcggtttga atcttgaccc gagccatttg ttatggatgg gcgcagaccc 851761 gatcatcgca gcaagggagc tcggctcagc cattcaccat gtccatggga aagatgtcag 851821 aattgaaaga tatttatcgg cggtcaacgg acttttagaa acaaaagaag tgacagatcc 851881 tgcaaaccgg gcgtggaatt acgtagctgt cggctgtgga caggatttac agtggtggaa 851941 ggaatttttt tcagttgtaa aaatgatggg atatgaaggt gaggtttctt tagaaatgga 852001 ggatctgacg atgtcacctg aagcgggcat ccgtacttct gtagaagctt taaaacaaac 852061 catcagccaa taggaggttt tcatgatgct aaatggagaa agaatcatct ctaagccgct 852121 tcgctgggca atggtaggcg gcgggcggct cagccaggtt ggatataaac atcgtattgg 852181 agcgctgaga gacaatactg cttttcaatt aactgctggc gcttttgata tcgatgccga 852241 aagaggaaaa gatttcgggg tgaaccttgg agtggatgcg gaacgctgtt atcccaacta 852301 tcaaaccatg tttgccgagg aagcgaaaag acaggatggc atagaggtag tatcgattgc 852361 cactccgaac ggcactcatt atgagatttg taaggcggcg cttgaagcag gagtgcatgt 852421 catctgtgaa aaaccgctgt tcttcacttc agcagagggg caggaaatca aagcgctcgc 852481 agagaaaaaa gggaaaattg tcggcgtgac gtacggtttt tcaggcaatc aaatgcttct 852541 tcaaatgcgt gcgatgattg aacaaggaat gatcggcgat attcgcgtgg ttgacttgca 852601 gtacacacac ggtttttgtg caacagatga aggtgaaaag ataagcgctg cacagaaatg 852661 gcgtgtcgac cctgcgatcg ccgggccaag ctttgtgctg ggcgatttat ctacccacac 852721 gtattatatg tcacagctta ttatgccaaa gatgaaaatt aaggagctgc tgtgtgaccg 852781 acagagcttc gtcggcagcc gcgcaccgct agaggataat gcccatgtgc tgatgcatta 852841 tgaaaatgga gcggtcggaa cgatgtggac atcgtcaatc aatgccggat gtatggatgg 852901 ccatagaatc cggattgtcg gctcaaaggc aagcattgag tggtgggaca gcaagccaaa 852961 tgaactgacg tatgaagtgc agggagagcc gggccagaca ctcgttcgcg gcatgccgta 853021 tttagatgat gtttgcaacg ccgatgaacg actgggcgcc ttacacagcg aagggctgtc 853081 cgaagcatgg gccaatattt atcttaaatt tgccattgcg atagacgcca aaaaccgtga 853141 agatgaagaa atcttgaaca acttggttta tcctgacatt gatgcaggga tcgagggcat 853201 tcgctggatt gagaactgcg tgcgctcggc aaaccaaggg tcagtttggg ttgaatttaa 853261 ataaatgagg gaatgcgccg catatgacat aaagttcata tgcggttttt attttccaga 853321 aactcctgtc aaaaatgccc tgaggcaggt atgataagaa gggaattggg tatcgggagt 853381 gatgagcgtg aaagctcttt tttttacgag aatgttcacc ttgatggtga gctgtttaat 853441 gtatctgtcc attgtgaaag aggataactg gtttggatat gtatttatag cagcaggtgc 853501 tgccatgtat gcagccaatc atgttttgct gacaaaagag acaaatgcca tctggttctg 853561 cctgattgat attgcaatcg gcttttcgtt cggatttatc tttcccggca caggtttgtt 853621 cattattatg ctttgtccgg ttgcggtcgc cttttttctg cgggggtttc ctaaaagaac 853681 agcatggtct gtcttatgtc tttcctctat tttatttttg accgtcctca tccgtacata 853741 tgcgatgttc ggcaatgaat ttgtcattga tcatttgact agcatgacat tcgttgtctt 853801 ctgcggtgtc gtgggcaaat taatccgcaa gctgttggat gcgcaggata cggcaaaaca 853861 gcagtttcag gaactgacgg agtcccatct ggcgctgtct gctgcacatc aggagctcca 853921 tttatatgcg aagcaggttg aagagctgac tgccatttac gagcggaaca gaatggcgcg 853981 tgaaatccat gatacagtgg ggcataaaat gacggccctt ctcgtccagc tgcagctttt 854041 gcgtgaatgg caaaaaagag acagccaaaa agcggatgag acagtaggtg tctgtgaaac 854101 acttgcccgt gaagcgcttg atgatgtccg cttatcagta cgcactctgc aaactgaaaa 854161 cgatccttcg ctaatcgaat cgctgaaaca gctgacagag gacttttgca aaaatgcagg 854221 agtcacaaca gaatttgcgg tcagcggtga tcctgcaatc atcccgctgt ctctccatcc 854281 gaccctgatc agaacggtgc aggaagcact gaccaatgcc aaacggcacg gcggcgccgc 854341 agcctgttcg atacagcttg cctgcacaac ggacagcatc agccttgtca ttaaggatga 854401 cggcaaaggc aatcctgagg cagcacttgg ttttggtctc ttgaatatga aaaagcgggc 854461 agcggagcat ggcggaatga tccgctttga aagcgaacgg gatcaaggat ttactgtaaa 854521 tgcagaattt tcacttgcca ataaaaaatg gagcttcggg cccgtgcagc aaaaggagag 854581 tttatcatga ttaagatcat cattaccgac gatcaggata tcgtcagaga agggctggca 854641 tccctgctcc agctccgaga agagctcgat gtgatcgcaa cggcgcgaaa cggacaggaa 854701 gccttcgaaa aggcgaaaga gctggagccg gatatcgtgt taatggacat ccgcatgccg 854761 gtttccaacg gggtggaggg aacaaaatta atcacaagct cgctgccaag cgtaaaggtt 854821 ttgatgctga caacctttaa ggattcagcg ctgattgctg aagcgcttga agagggagca 854881 agcgggtatc tgctgaagga tatgtctgca gatacgattg taaaagcagt gatgactgtt 854941 cattctggcg gaatggtgct tccgccggaa ttgactgccc aaatgctgaa tgaatggaag 855001 cgtgaaaaac agctgaaagg aataaatgag atagaaaaac ctaacgagct gctcgacctg 855061 accgagcgcg aaatcgaagt tctggctgag ctgggatacg ggctgaataa caaagaaatt 855121 gccgaaaagc tttacattac agaaggcaca gtcaaaaacc acgtttcaaa tattatcagc 855181 aagctggctg tcagggacag aacccaagcc gccatttact cggtcagata tggtgtatct 855241 gtcttttgac atatgacgtt ttgcatatac gcttctctga aaaggccttt tacaggcctt 855301 tttttcatgc cctatgttct atctgccgct acatgccgca cgcctttctt tcttctacaa 855361 tggcaatgga tcaaaaaaag gagtgagacg acgtgctgca agcagaaaac atcaaaaagg 855421 catacggaaa aaaaacaatc gtgaaaggca tttctttttc cctcaaaaag ggggagtcgt 855481 tcggtctgct cgggcctaac ggtgcgggga aatccacaac catctcgatg atttccggcc 855541 ttgtgccgca tgacagcggg aacatcacgg tgggcggcta tgttatcgga aaagaaacgg 855601 ccaaagcgaa acaaaaaatc ggcattgttc cgcaggaaat tgcattatat ccgacgctga 855661 cggctcatga gaatcttatg ttttggggga aaatgtacgg acttacgcac ggtgaggcca 855721 aaaaaagagc ggctgaggtc cttgaatatg tcggtctgac tgagcgggct aaagataaga 855781 ttgaaacatt ttccgggggg atgaaacgaa gaatcaacat cggtgcggct ttaatgcata 855841 agcccgagct gctgattatg gatgaaccga ctgtcggtat tgaccctcaa tcgagaaatc 855901 acattttaga aacggtcaaa cagctcaacg aaacgggcat gacggtgatc tatacgagtc 855961 attacatgga agaagttgag tttttatgcg accggatcgg gataattgat cagggggaaa 856021 tgattgcgat tggcacaaaa actgatttgt gcagccgcct tgggggcgat accatcattc 856081 agctcacggt cagcgggatc aatgaagcgt ttcttgtggc gatccgatct ctggcccatg 856141 tgaatgatgt aacagtacat gaattagagc tcaaaattga catttctgcg gctcatcatg 856201 agaaagtcgt cacaagcctg cttgctgaag ccactgctca tcatataaac ctgctgtctc 856261 ttcaggtgca ggaaccgaat ctggagcgcc tgtttctgaa tctgaccggc cgcacgttgc 856321 gggattgagg agggacggca atgaaaaaaa gcatatggat cgcatggaaa gatgtgaaaa 856381 tcagaatcac ggacagaaaa gggtttatga tgcttatcct aatgccgctc atcctaacct 856441 gtattttagg cgcagcgctc ggatcagttg ttgacggagg cagccggatt gatgatatca 856501 aagtcggcta cattcaatca gaccagtcag atacagcaaa catgtttaca aaagatgttc 856561 tcaaaaaaat gaagtcgata aaggtcacaa aagtcggcag caaagacaag atgaaaaaac 856621 tgattgatga aaagaaaatc gatgtaggca tcgttatccc gaaccattgg gaagccggca 856681 aaacctcagc tgttgttaat gccgctcctg atcaaacatt gaaaagttcc atcattgaaa 856741 cagctgcaag ctcatttata gagcaatata aagcggtaaa ggaagccgcg tcaggctcaa 856801 tggactacat cagtaaaacg gaagctgtaa agcaaggaaa acttgaccct gcacagtttg 856861 cagaaaagct ggcaaagacg ctagaaaaag aaacaggtga caagcttact attgcggaaa 856921 aatctgtcgg cagcaaagcc gttaccagtt ttcaatacta ttcggcggca atgctttgca 856981 tgtttatgct gtttcatatc acagtcgggg cgaaatcatt tttacaggaa aaggatacgg 857041 agacgcttgc cagaatgctg atgacgcctg cgcaaaaatc cgtcattctc ttcggaaaat 857101 ggcttgggac gtatctgttt gccatcatac aatttttcat atttctgatc gtcacaatca 857161 acgtatttgg tgtggactgg ggcggtaatc tgctgttagt gagtgtactc gggctttctt 857221 acgccgcagc tgtatctggt atttcaatgc tgcttgcgtc gtgcatcagc gatatgaaaa 857281 ctgcagatgc gataggcggc ttcggcattc aattgcttgc ggttctcggc gggtccatgc 857341 tgccgctgta ccaatttccg gacgtcttgc agtctgtatc caaagcggtg ccaaatcgct 857401 gggcgcttga cggctttctt tctttaatgg aagggggagg ctgggctgac cttcaaaagc 857461 ctgtgcttct ttttgcggcg atcggctttt gttcacttgt aattggtatc agacggcttc 857521 atacaagata aggaggtaca aaaggtgaaa aaaattctag ccatttgcgg cattgagctt 857581 tctctcattt ttaagaagcc acagaactat ttgatcatgt ttgctgcccc gcttttgctt 857641 acctttgtat ttgggagtat gctcagcggc aatgatgata aggtgcggct tgcaatcgtt 857701 gatcaggacg atacgattct ctcacagcat tatattcggc agctgaaggc acacgatgat 857761 atgtatgtat tcgaaaacat gtctgaaagc aaagcgtcag aaaagctgaa acaaaagaaa 857821 attgccggga tcatcgtcat ttcccgctcg ttccagacac agctggaaaa aggcaaacat 857881 cctgagctga ttttccgtca cggccctgag ctgtcggaag cgccgatggt caaacaatat 857941 gcagaaagcg cattggcaac gctcaatatt caggtgaccg cggcaaaaac ggcatctcag 858001 acagcgggag agaactggaa ggcggcgtat aaaacggttt tcgccaaaaa acatgaagat 858061 atagttccgg ctgtaacacg acagacgctc agtgataaaa aagagggtgc ggaagcaagt 858121 gacacagcct ccagagcagc agggttttcc atcctgtttg tcatgctgac catgatggga 858181 gcggctggaa ccattttaga agcaagaaaa aacggcgtat ggtccagatt gcttacagcc 858241 tctgtcagcc gagccgaaat cggtgctggg tatgtgctgt ccttctttgt cattggctgg 858301 attcaatttg gaatattgct tctttccacc cattggctgt ttggcatcaa ctgggggaat 858361 ccggctgcag ttattgtatt agtgtcactt tttctattga ccgttgtcgg cattggattg 858421 atgattgcgg ccaacgtcag aacgccagaa cagcagcttg cgttcggcaa cttgtttgtc 858481 atcgcaacat gtatggtgag cgggatgtat tggccgatcg acattgaacc gaaatttatg 858541 caatccatcg ctgaatttct tccgcaaaag tgggcgatga gcgggttgac agagattatc 858601 gctaacggtg cccgcgtcac agatattctc ggaatctgcg gcattttgct tgcatttgct 858661 gcgatcactt tcgcagcggg gctgaaagcg ctccgagcct aaaaaacatc tgccgtttag 858721 gcagatgttt ttttgcatgt gggtacattc gtatgggtgc agcctgaact gcggttaatc 858781 cttatctatc atagctaaaa ttgattccag ccaagaaacg taatttttct cccgctccag 858841 cgctttcgtt agcacaagat agtggccgaa gtccggtgaa gaaaatgaca tcggctctgc 858901 tgaagccata agcttttcat agcttccctg taagtcagaa agcttggcct ggcgtttttg 858961 cagctggtct ttgaacaaat cagaagcctc ctggcgcgat agacaagaaa tgaaataagc 859021 cttcagcata aattcatcct tcaccgtctc gggtatcggc tggtggcgga tcagccagtc 859081 atgcagctcc tgctttccgc tgtctgtcag ggtgtacatc tttttctcca gctttgtgcc 859141 ctgaatcgtt gtccggaacg tgataaatcc ttcatccgtc agctttttga gctcagggta 859201 aatctggctg tgcttggcgc tccaaaactg gccgagctcc tctttaaaat aactcgtaat 859261 atcgtatcca ctcaattcgc cttttcgcaa aagccctaat atggcgtatt ttaatactct 859321 catgctatcc tccgtgtctg gctgtttcgc aaaacagatg agccggtgct caactgtgat 859381 tctaactgcc tattcccctt attatagaaa agggaggaag ggaacacaac cgggctcttt 859441 ggaaatgaag ataaaaggtt tgtcagaagg tatccgattt atctccgtca atataaaaga 859501 gatttaaatt taattttcag aaaaaatagt aacgatattg attttttata tataatagga 859561 aattggtggt atgaaaattt tttgggggaa taaacgtgaa aaaagtactt atggcattca 859621 ttatttgttt atcgctgatt ctatctgttt tagccgctcc gccgtctggc gcaaaagctg 859681 agtcagtaca taatcctgtc gttcttgttc atggaataag tggtgcatca tacaactttt 859741 tcgctattaa aaactactta atttctcaag gctggcaaag caacaaactg tacgcaattg 859801 atttttatga taaaacagga aacaacctaa ataacggccc gcagcttgct tcatatgttg 859861 accgtgtttt aaaagagact ggggcaaaaa aagtagatat tgtggctcat agtatgggag 859921 gcgccaatac gctgtactat attaaatatt taggcggggg caataagatt caaaatgtcg 859981 taacgcttgg aggggctaat ggtttagtgt catcaaccgc gctgccgggc acagacccta 860041 atcaaaagat cctctataca tctatttaca gtctcaatga tcaaattgtc atcaatagct 860101 tgtctcggtt acaaggagcg cgaaacatcc agctttatgg catcggtcat attggcttgc 860161 tttctaatag ccaagtgaac ggctatatca aagaagggct gaatggcgga ggcctcaata 860221 caaattaata tcttcaaaaa acaacctgct gtctccgtta cagtgggttt tttcgtctga 860281 gaaagccata gggtcttatg accttagtct atcatgcata cgtcaattta tgacatcagg 860341 cactttttca aatagagcgg acatgttaag gtacaaccat cgatttctat caatttgaaa 860401 taaaaggagc gctgttatgc aaattaaaga aatttttatg atccgctgca tttcgtgctt 860461 aagtgtcgtc ttgctccata tcatttcaat ggtcctgatg cttcaggcag aagctcttgc 860521 agatatttct cacactgttg attctttccg cacactcctg atgttcagca cgcccgcttt 860581 tattttcatc tctgaatttt tactggcccg ttcttatcct gatggggtgc ctgacggttt 860641 tttaaagaag cggggaaaag tgatttttgt tcctttttta tttatcgcag ccatcgatgc 860701 gctgctgatg accagtgcga tggggggaga ggtaaccttt ctcgcgtttg tgcaaaaata 860761 tctggcgaac gtattcttag gaaactttat cggatacttc attctcgtca tctttcaatt 860821 ttacatgctg catatgatgt ttcatgagta tttgaaaaaa gcatcgccga aatgggtgct 860881 gtctatctca tttgtggtga cagccgctta tttaggctat ttctccgcag ccagcccggc 860941 tcctgcttct gaagagggag gggcatttcc gttcttctgg gttccgttcg caggctggct 861001 tttctacttt tgtctagcct actattgcgg aaaagaatac aagcgttttt tagcgctgct 861061 gaaccaatac cgctgggtgg tgtacggcgc cgcaattgct tctggggcgc tggttgtcac 861121 tgtttcttat gtcggtgaaa tcggcatgat cagctcgaag cggcctgata tcatgctgta 861181 ttcaacaagc atgattttcc tgtgttttca tttgttttcc aaaatgaagc atgtgccgaa 861241 aatcatgatg tttatcagca actattcctt ttcgatttat ctgcttcatg cctattttat 861301 gattataggc tacgtgttgc ttttgaatat gcccgaaatt cctgccgtac cggctgttct 861361 cctgttgttt gccgtgtgca cagccggccc gattatgacc tcatgggcgc tgaataagtt 861421 caaatacggg tatttatttg tggggaaaat ttatcagcca aaacagaaga aggtaacagt 861481 cgaagtgcgt gatcacgcag ggtgaaaaac aagcggcagg agggctcctg ccgcgtttct 861541 ttacttctca tccgcttgca gaactgtttt taaatatagt tttgcagact cagcaagtcc 861601 agatacatca gccttttctt catcgaaata cagggcgttt tgaatgatgc cgtcattcat 861661 attgaggaaa aacttggcga tagtcgcaag aggctgaacc ggctgaaact ctccctgatc 861721 gatccctttt tgcaatagcc ttgaaaacct ttccacaaaa agatcatacc ttttctccaa 861781 atactgccgc cgttcttcat tgcgccaagc tgtcactaaa tattcaaatt gcaccggcgc 861841 cagcgtatct gctacatctc gcaggccctc agtcagttca tccaaatagc tggaaatgga 861901 ggcccaaaca ctttggtgtt cagctgattt atcaagcttt cggagtcctt catccagccc 861961 tgtttcaata atgcggcgaa acatctcctc agtgcttgaa aaataaagat agacaccgcc 862021 ccggctgaaa cctgactctt ctacaacatc cttcatcgtc gttaattcga atccttttcg 862081 tttaaaaacc gttttggcag cctctaaaat ctctgcctgc cgtttatcct tgtgctcctt 862141 tgttactttt ggtgacaaga tatcgcctgc tttctgcaat tttcttacct ataagtgtaa 862201 tcaacccaat catgatcagc aagcagccac agacaagaaa agcaagtgat acaccgatcc 862261 attccgccag cacgcccccg cccgccatgc cgaggataga ggcgagggtt gtcgcactct 862321 gaatagcgcc gaacacccta ccgctgtaat cgacaggcac tgttgtttgc acgagaatct 862381 gaaatggaat atggacgagg ccgaaagccg cccccatgat gaaaaaagca aatataaaga 862441 gagtgatgcc ggcaattccc ataccgctta ggaatggcgc acctccagtt gctagtccaa 862501 gaagaagggt tccagctgag aaataaagca aataagaagt gattcgccgt ctgccggtaa 862561 tggccgctgt aaggagcatc ccggctccgc ttacggccat gcaccagcct gccagctcgg 862621 gcggagctcc tgaaaaggag cggataagaa taatcgcttg ggaatcacca atctgcaaaa 862681 caaagagaac gacacaagct gttagtaagc ctgttaatag aagcggcatc cgtttcaaaa 862741 actgaaggcc ttccttgata gaagtaagtg ctgctgtttt ttcttgaggt gtattggctt 862801 tttgtaaaaa agcatctctg ggaaggaaaa acaaaatgac agcggaaaga aagaaggcgc 862861 cggcgtttat ataaaaaaca gagtgtatcg agaaagcagc gatcagcgtg ccgccaaggg 862921 cagggccgaa gatttttgag ctgttatcaa tgatgctgct gacggaaacg gcctgctgaa 862981 tgtgtgcttc cggagccaat tccttaagct ttccgttttt agcaggtaaa aaaagtgaag 863041 aaaaacagct ctgaacggat agcaatacgt aaagctgcca aagctcactg acataaacgc 863101 agctgataac agtgagggca cggccgattt cagatagaaa catgatcgtt tttctgtcaa 863161 aacggtcggc aagcagaccc gatacaggtc cgagtacaat gacaggcaaa gcaaacgaca 863221 tcattaaaag cgacatatct aatggagaag catgaagctg aaaagcggct aatgttagca 863281 cggccaaaat gtgaagccag tctccaagtg aagaaatggt ttgcgaggct aacagtgtca 863341 tcagtccttt ttgattgcga aacaacggtt tttccatgat tcatcctcct gattattaaa 863401 atgacactag tgtcgttttt aattgtatgg gaaaaagaca caatatacaa tctttttctt 863461 gtaaaataaa ggagaagatt gaatagaagg gagaacattc atgacatcag tcaatctaag 863521 ctacccaata ggagaataca agccgaggga atccatatcg aaggagcaaa aagataaatg 863581 gattcaagta cttgaagaag tgccggcaaa attgaagcaa gctgtagagg tcatgacgga 863641 cagccagctt gacacaccgt accgggacgg tggatggacc gttcggcaag ttgttcatca 863701 tctggctgac agtcatatga acagctatat tcgttttaaa ttgagcttga cggaagagac 863761 accggctatc cgtccgtatg atgaaaaagc atggtcggag ctaaaagact cgaaaacggc 863821 agatccgagc ggctcactcg cgcttttgca ggagcttcac ggaagatgga cggctctgct 863881 ccgcaccctg acggatcagc aatttaagcg cggattttat caccctgata caaaggagat 863941 cattaccctg gagaacgcgc tcggcctgta tgtctggcac tcacatcacc atatcgctca 864001 tattacggag ctttccagac ggatggggtg gtcttaacgc ttttgccggc ggaaagccgg 864061 aatactgata gcagcaatca ccagaagtga gaccacagca gccgctgcat ataaatgatc 864121 atagccgctg gcgacactcg catgaatggc gtcgcttatc gcggttttga cttcaggaac 864181 gggaatgcgt tcgatttgtt cttgtaaaga agaaacttca gaactgtcga tctccggaat 864241 catctgcatc gccttttctg aatatccgct gtccgataag cggctgttga tctcatcacc 864301 tatttggtca aacccggctg tgataaaacc tgcataaaga gtaggcgcca aggtcagtcc 864361 aatttgcctt actaatgaaa gcgtgccaag agctgtaccc ttatttgttt ttgccgcttc 864421 tgatacaagg acgttcagcg gagcgcctaa cagaaagcca aaaccgatcc cagctgccac 864481 acttgcgatc acaaactccc atttttccgt gacccagagc ggaaataaag caaaccccgc 864541 acatgagatg attcccgaaa gaataacggt ttttacagga ccttttttgt cggtaagtgc 864601 tccgccaagc caagcgccga ttccggaagc caacgcaagc ggtgtcatcc aatagcctgc 864661 ttttgcggca gggacaccca aatactgttc gacatatgac gggataaaaa tgactgccgc 864721 caagagcccc ccggataaca aaccgatgat aagcgtgcgc tgaaacatat ggtttcgcag 864781 cagagaatac gccaaaatgg gatcgcctcc tcgcatttca actctctttt catacgagat 864841 aagcgctgca aaacagagta tgccaaaaat aatacatcca taaacctccg gattccccaa 864901 gctgtgtaag agatttgccc cgtcaagatt ggtcatgccg tacatcacag ctaaaatcga 864961 cagggacaaa aggaagattc cggccgcatc gaggcgctta gcctcaggtg cttttgtttc 865021 cgcgataaaa catgcgccga aaacaaccaa tagcacggca atcggcaaat taatcaaaaa 865081 tagccaatgc caagacccgg tccaatcaag cagaaagctt ccgatatttg gcccgagcac 865141 agcggccatc ccgttcattg cgccaagcag cccaagcgcc ttcccctgtt tttcctttgg 865201 aagggtcgcg agaatgtgag agctgccgat gatgaaaatc ccgccgcctc caagcgcctg 865261 aatcagccgc gatatcagaa agagcgggaa gctttggctc aaagcaacaa gcaaagaacc 865321 aagtccgaac aggcaaacct caatgagaaa gagttttttt ctgccgtagc ggtcggaaag 865381 ttttccgacg attggcacac tgacgctaag accgagcgta taaagggtaa tgccccatga 865441 tccccaggaa ggggaaacgg aaaacgactc gtttatcgtt gttaaagcag ccgaaataat 865501 tccgttatct aaagcagcca taaacacgcc aatcgtaaac aggctgattg cccacttttg 865561 gcttttctgc tctgttaatg cttcagacat tttcgtcaac tccttttagt tcacttgaaa 865621 tatattattc attttaaatg aactaaatgt caaataaaaa aagcctgctc ccgcagtttg 865681 cggatgacag acttactgat ttattctttt ttcgcattct ctaatgctct tgaaaggata 865741 gacagccctt cgtaaacagc ctgcttttct tcaggggaca gcagctctaa tgaacgcttc 865801 aatttcaggt ggcccttttc atacaaaccc cggaaaatct ttttcgcatt ctctgtcaac 865861 tgaacaacta cagagcggcg gtcctcttca gaatgtgagc gtttgacaaa tcctgatttt 865921 tcaagccggt caagcagccc agttgtattg gacagggaag cccccatttt ttcagcaatg 865981 tcgctcactt tcaatgttcc atggttgttt aatagcatca gcaccttcat ttgcggcatg 866041 ctcatatcca gtttcatcca ctcggacaca tcaccgagcc cggcggacgt taagactttc 866101 atatagagca cccatatttc ccgttcctcc gatgaaagaa tgttttcgtt taagactgtt 866161 gtatcgtgta aattatattc catttcatca cttcctcatc attcactcct cttaccatat 866221 tactcgattt tcactcctga aagaaagtga gcagaaaccg catgcgggac tttgtccgaa 866281 aaataacggt agtgtataat gagttggaga ttattggggg agaggatcga actagaatat 866341 gattggagag accattgctg attaaaaaga atgctttatc aatattaaaa atcgtttttc 866401 ctattgctgt tttgctattt gttatttatc aatcgaaaaa agaactgaca aatctgtcat 866461 tcaaacgtac gctcatggtc atcaacggac tggaacgaac ggatttattc atgcttgtgt 866521 tgatcggctt gctggctgtt gcggctatgt cgctgtatga ttacgtcctg aagtactcac 866581 tgcgcctatc gatcacaaac ggaaaagttt tcagggtttc ctggatcgcc aattcattta 866641 ataatgtgtt gggattcggc ggtttagccg gagtcgggtt aagaatgatg ttctataagg 866701 agcatacgaa agaccataag gcactcgtga aaggaatcgc ctggctcaca tcatctatgc 866761 tgctcggatt atctgttttc agcattttcg ttgctgcgag agtgctgcca gttgatgaag 866821 tgattcatga gaagccttgg ctgtgggcgg tcgttatcgg ttttgcactg atattgccgt 866881 tatctttagc ggtgtccaaa ataaaagacc gcaaagctgg ggacgaagag aatgcggata 866941 aagtgaaaaa tccgattttc gcatatattg gagcttcagt tgttgaatgg ctcatggccg 867001 ggaccgtcat ctattttgct ttgttcgcta tgggcattca tgcagatatc aggtatgtgt 867061 tcggggtgtt cgtcattgcg gcgatcggag gaatgatcag cctcgtgccg ggcggcttcg 867121 gctcgtttga ccttttattt ttgctgggga tggagcagct tggctatcat caagaggcca 867181 tcgttacttc tattgtgttg tacaggctcg cctactcatt tatcccattt atcttgggac 867241 tgttctttgc cgccggcgac ctgacggaaa atacaatgaa gcggctcgaa acgaacccgc 867301 gcatcgcacc ggcaattgag acgacaaacg ttctgcttgt tgttcagcgt gcggtattag 867361 tgagaatttt gcaaggctcg ctttccctta ttgtgttcgt agcaggtctg attgtcttgg 867421 cctcagtttc cttgccgatt gacaggctga cggttatacc gcacattccg cgcccggcgc 867481 ttttgctgtt caacggcctg tccttaagct cagcgctcat tctgctcatt ttgccgatcg 867541 agctttataa acggacaaaa cgttcctaca cgatggccat tacagcgctt gtcggcggct 867601 ttgtgttcag ctttttaaaa gggcttaaca tcagcgcgat attcgtactg ccgatgatta 867661 tcgtattgct tgtgctattg aaaaaacaat ttgtccgcga acaggcatcc tatacactgg 867721 gacaattgat attcgctgtg gcgctgttta ctgtggcgct ctttaactac aatctgatcg 867781 cgggctttat ttgggaccgg atgaagaagg tgctgcgtca cgaatatttc gtccacagca 867841 cctcgcatat tacacatgca accatcatgg cgatcatcat tgtgccgctg ttcttcttga 867901 tatttacagt ggtctatcat aagagaacga aaccgatcgg agagaaagct gaccctgagc 867961 gtcttgctgc gtttctcaat gaaaaaggcg gcaacgcgct gagccatctt ggttttcttg 868021 gagataagcg gttttatttt tctagcgatg gaaatgcact gcttctgttt gggaaaatcg 868081 ccagaaggct ggtcgtgctc ggcgatccat ctggccaaag agaatcattc ccgctcgtgc 868141 tggaagaatt tctgaacgaa gcgcatcaga agggattcag tgttttgttc tatcaaattg 868201 aacgagagga catggcgctg tatcacgatt ttggctacaa cttctttaaa ttgggtgagg 868261 aagcatatgt agatttaaat acatttacct tgactgggaa gaaaaaagcc ggccttcggg 868321 caatcaataa ccgctttgag cgggaggagt atactttcca tgtggatcat cccccatttt 868381 ctgatgcgtt tttggaggag ctgaagcaaa tctcagacga atggctcggc tcgaaaaaag 868441 agaagggatt ctcgctcgga ttttttgatc cttcctattt acagaaagcg ccgatcgcct 868501 atatgaaaaa tgcagaagga gagatcgttg cattcgcaaa tgtcatgccg atgtaccagg 868561 aaggagagat atcggtcgat ctgatgcgct atcgcggcga cgctccaaat ggcattatgg 868621 acgcattgtt tatccgtatg tttttatggg caaaggaaga gggctgtacg tcatttaata 868681 tggggatggc acccttggcc aatgtcggca ctgcctttac atccttctgg tccgaaaggt 868741 ttgccgctgt catttttaat aatgtcagat acatgtacag tttcagcggc ctaagagcct 868801 ttaaagaaaa atataaaccg gagtggcgag ggaaatactt agcgtatcgg aaaaacagat 868861 ctctttctgt caccatgttc ctcgttacac gtctgattgg caaaagcaaa aaagactccg 868921 tctaataaga cggagtcttt ttttatttcg tttttaagaa gtaggtttca atatcatcaa 868981 gcaggtagtt tgcggcttta attccgcctg cggttgtcca tacgacgtca tcgacttcat 869041 gtgcattacc tgacttcacg gccttcaggt ttttccatag tgaactgctt gtccactgat 869101 tggcccattt ttcattttct tttgcattat cggctttata agtgaaataa aacagcacat 869161 cagcatccat atcaggaata gattctttac tgtcggttga gaacgtaaat tggtcctttt 869221 gtttcttaaa cagttccact tgtttttcag ggcgtttgaa gccaagctgg tctaaaataa 869281 tcccaggaaa tgaatcggta taatagattc ttgattcacc ggataaaaag cgtacgactg 869341 aaacggtttt gtttgtctgg tcgcccagct tgttttttaa atcagaaaca cgtttatcaa 869401 aatcggcaat gacttccttg cctttgtccg ccttattcac cgcgttggcg tatagagtca 869461 ggttatcctt ccagttcccg gccaaagatt cagcaaaaac agtcggcgca atcgcattta 869521 actgatcata aattttttcc tggcgcactt tgtttccaat aatcaaatca ggctttaatt 869581 ctgcgatggc ttccacattc ggttccgttt caagaccgac gtttttaaca cctttcatgt 869641 catctttcag atagtcatac cacgggtcgc ccttccatga ctttacggct ccgaccggct 869701 taatgccaag cgctaagagc gcctctgttc cttcattagt taaaacaaca atccgttttg 869761 gattggcggg gatgttgtct gatgtcccca ttgcatgttt gaccgttctt gttttgctgc 869821 ttgacacctc gctgttgctt gaactttctg aactattaca ggcagaaagt accataacgg 869881 ccattaaaaa tacgaatagc atgctgatat gctttttcat ctttttcctc ccaatattga 869941 aattcattat catttagatc ataataagca gtgttaagag tgtcaatccc taattgagga 870001 ttattctcaa aaacaaacat tacatagtaa ataactagga gaattagatc atgatctgca 870061 aaaaggcatc ttcaaaatgg attgtgttag tatgtctgat tttcatttta ctgacggctg 870121 tctgcgcaag cgtcgtgtat ggctatacag gtacgtcatg gagacaggtc tatcaggcgt 870181 ttacttcctt caatggaaca aatgagcatg tcatcatcaa ggatgtcagg cttccgcgcg 870241 ctttggttgc gacagtcgtc ggcgcctcgc ttgcagccgc gggcgctctc atgcaggcgc 870301 tcacaaaaaa tccgcttgcg tcaccgggga ttttcgggat taacgccggt gcaggttttt 870361 ttattgttgc cggatcgttt tttctgcata ttcagtcacc tcaggcatta gtatggagct 870421 cgtttctggg ggcagcattt accgctgcga tcgtctatgc agcaggctcg cttgggaggg 870481 aagggctgac gccaatcaaa ctgacgctgg cgggagctgc catggcagcc atgttttctt 870541 ctctgacaca gggcttgctg tctgtcaacg aactcgagct tgcccaggtg cttttttggc 870601 tgactggctc tgtgcagggc cggagtctgg atctgttgat gacgatgttt ccatatgcag 870661 cggcagcgct ggtaatctgc ttctttctcg gccaaaaaat taatctcctc gttatgggag 870721 aagatgtggc aaaaggactc ggccaaaaaa caggcctgct gaaatttgtg atggcgcttt 870781 gtgttgtcat gcttgcaggg tccgctgtcg ccattgccgg gccgatttct tttatcggca 870841 tcattattcc gcattttgcc cgctttgtcg ttggtaatga ttatcgctgg gttctgccat 870901 tttccgctgt tttgggtgcc attttgcttg tttgcgcgga tatcggtgcg cgatatatca 870961 ttatgcctca ggaagttcct gtcggggtca tgaccgccat catcggaatg cctgtgtttg 871021 tgtacatcgc aagaaggggg gcgaagctat gaaacttcgt tttggcgtta ctgcggctga 871081 aaagaaagca tggatcgtct ttttggtttt actggggtta acagctgctg tactcatcat 871141 aagcgctggt ctcggacaaa ggtttattcc tccctgggat gtagcaaaaa cattctttgg 871201 tgcaggttcc aagctggatg aactgatgat catgtcgttc cgcatgccaa gaattttgac 871261 ggctttatgc gccggtgtct gcttggcagc ggcaggcgcg atattgcagg ggctcgtcag 871321 aaaccctctc gcatctccgg atattatcgg aataacagga ggagcggcgg tagcggtcgt 871381 gcttttaatg atgttcttct cagaccgcag cagttcactt acgatcagtc tgtcatggct 871441 tccagcagcc gcatttatcg gcgcatcggc tgtcgggctc atcgtctatt tactggcata 871501 caaaaatggc gcctccacat ttcggctggt gcttatcgga atcggatttt caatgtcggc 871561 gcaggcgatg actaccctgt tgatgatcaa aggcccgatt taccgagcat cacaagccaa 871621 tgtgtatatc actgggtcag tttatgggtc aaactggcag catgtaaaaa tagctattat 871681 cttatctgtc attctcttat tcatttgttt tgtcgcgcta aaaaatatga atatacaggt 871741 gctgggtgaa gatattgcgg cgggtgcagg aagcgctgtg cagcgaaatc gttttttctt 871801 gctccttttg agtacggctc ttactggttg tgcagtttca gttgccggca caatcggttt 871861 tgtcgggctg atggcgcccc atattgcaag acggcttgtc ggctcatctt atggcgcgct 871921 gctcccagcg tcggcactta ttggagctct gctcgtttta acagctgata tcgtcggcag 871981 aaccttattt gctccggtgg aagtgccggc cggcgtcttt acagcggcta tcggcgcacc 872041 ttattttatt tatttgctct ataaaacaag aaattcttaa tcgttacacc cattttctta 872101 aaaaagaaaa tgggtttttt tgataatgac tgaagattcg taattatttt tgctatactg 872161 acagagacat tgataaagaa agggcggcag atgaatgaaa gaagcagagg tattaaaata 872221 tgaagcattt acaagcagtc ccggcaaagg aaaccccgca ggcgtcgttt tgcagggaga 872281 cgattatacg gaagacgaga tgcagatcat agctgaacgt gccgggtatt cagaaacctc 872341 ctttatccga aaaagcgagt cggccgatct tgaactccgt tactttaccc ctggacacga 872401 aatgaatttg tgcggtcatg cgacagttgc ttctctttac gcattatgtg agaaaggaat 872461 gctggagagc ggtaaaacgt acagcatcca aacgaaagcg ggtatcctgc ctgtgaagat 872521 ttctgaaaaa gatggccgca ttcatatcac gcttgaacag gcctctccgc aattcaaacc 872581 atttacaggc gatcggaaaa aacttgcgga cgcactgggt atcaccgatg aagattttca 872641 tgaagacctt ccgattgtgt ttggcagcac tgggatatgg acagccatcg ttccgcttaa 872701 atcattggag gcttccaaaa aaatggtgcc agataacaaa caatttccgg aagtgttagt 872761 tgatctgcca aaagcttcag tccatccgtt tacctttgaa accgtccatc ccgacagcga 872821 cctgcacggg cgccactttt catccccgta ttcgggaacg attgaagacc ccgtgaccgg 872881 cacagcatcc ggcgtgatgg gggcttatat gaaacattat ggcaatgccg agcagcataa 872941 atttatcatt gaacaagggc aggaaattgg aaaagacgga aaagtggaga tcgaaatgaa 873001 cgaagccggc ggccatgtga aagtgaacat gacaggaaca gccgtttact cagaaacccg 873061 tattcttaaa atctaatacg gatgatggtt tacaaaaaga tgcactttcc gttatcatta 873121 tgaaatgata atcattttca attgcatagg aaggtgagac ggtatgcctc aaaccgaaca 873181 aatacatcag cattcagtac tgagggacat catacgcagc agaagatcga ttcgaaagtt 873241 taaacaagag ccagtacctt cagcagtcat tcttgacatg cttgaaacgg caaaatatgc 873301 gccaaatcac agagtgacag agccatggag atttatttac gtttccagtg agacaggtaa 873361 agcgaacctc attaatacat ttgcagcgtt ctctaagaaa tccaagccgg atatgacaga 873421 ggaaaagctt caaaatttca aaaacacact tgggcgcgtt ccgggatttc tcctcgtcgt 873481 gtttcaggaa gatgaaaacg aaagagcgcg ggacgacgat tttgcggcaa caagctcgtt 873541 gattcaaaat cttcagcttc tcgcttggga aaaaggaatc ggcatggttt ggaaaagcgg 873601 aaaaatcctt tatgacaaag aagtccatca ggcctttggt ttacaggata atgagcgttt 873661 cgccgccatc atacaaacag gttatcctga cgaggcgccg gaagtgaaaa aacgcacacc 873721 gatccgcgac cgattcactg aaatgtaaaa aaccccttgt ctcaaacgga gacaaggggt 873781 ttttcattaa cgagatttct ttttcgctct gttgtcggct gctttcgcac gctcttgcgc 873841 ttcgcggtca tctgcatcag caagctcggt tgaatattct tcgtaaacgc cgtcagtttc 873901 cctttttaag gcatcgggaa cttgtggaag cttttgtttg tttttatcac ggtttttgtg 873961 gatatgattt ctgcccatat caaattcccc ctaaaaagtg atatcaaaca aatatagtat 874021 ttggttttaa ggggctatgt attcctactt ccgcttagca gctttttccg cttttttaaa 874081 ttcgcctgaa taaagaactt cctgcatttt tttcaggttg gcgccttgct ggtgcttctc 874141 cctctttttt tccataaaaa ggacctcctt caaccatgtt attcttaagg ttgacgcttc 874201 ctgctgtttt tatacagtct ttcggtccgc tatcagctgt gagagtgcaa attcaagatc 874261 cgaatatgta aaacgaaatc cagaggttat cgcttttttc ggaagagcgc gctgtccttt 874321 cacaatcaaa agactcattt cacccaatgc ttttgataaa aagaattccg ggacggggag 874381 ccagtgcggg cggtgcttca cccgtgcaat cgtttttccg aattgcttca tgtccacagg 874441 attgggcgcg gtgacattca ttgggcctga gatgccggcg ttttccaccg catatcggat 874501 catctgggcc gcatcctcga catgaatcca tgacagccac tgccttcccg ttccgatcgt 874561 tccgccggcc agaaacttat aggggagaat catgagcggg agagcgcctt tttctccaag 874621 catcacgcca aatctcgcat aaactgtccg gatgcccatc gcttcaatat gctgtccttc 874681 cttttcccac aggtgtgcag tatggctgag aaaatcctca tctgacgttg cagaatcctc 874741 tgtgaaagtt ttctcaaggc ttgtgccgta aatgcccacg gcactggctt ggatcaatgt 874801 cttcggcttc tccttctgtt tctgaataag ccgctgcact tcacgcgtcg cattgatacg 874861 gctggagaga atgtgctgct tcgttttttc tgtccagcgg ccaaaaatcg attttcccgc 874921 aagatttatc cagacatcaa tatgaggaag ttcctgctcc ggtgcggctc cttccgacag 874981 ccattggaca tatgtcatat ttttttgttc agtttccctt gcgtttcttg ataaaatata 875041 aacatggtgt ccctggcggg taagaacgcc tgtcagatgc tggccgagaa aaccggttcc 875101 gcccgtcatt gcgatattca tgaacatctc tcctcatcgt tctaataaat atactttacc 875161 tcattgtaat aaaagaaaac gcgtttcagg cctgagaagg gagattaaga tgccgtttat 875221 tacaaaaata tcaacgcaaa aaaagaatac ggaacgcttc aatatttttc tggatgataa 875281 atacgccttc agcgtggacg cggatgtgct cgtgaaattt gagctcaaga agggaaaaga 875341 actcgatgat cttgacatca ttgagattca atacggcgat gaagtgaaga aaggcttcaa 875401 ccgtgcgctt gactttttat cctatcgaat gcggtcgacg aaagaggtcg aggatcactt 875461 aaagaaaaaa gaaacctcgc cccccgtcat tgcggaagtc atccataggc ttaacgatta 875521 caagtactta aacgaccagg aatttgccgc agcctatgtc agcactcaca aaaaaacaaa 875581 cggaaaaggc cctgatgttt tgttcagaga gctaagagcg aagggaattg atgacgatac 875641 aattaaggag gcgctaagtt ccttttcctt tgaagatcag acaagagaag cggtcaagca 875701 tgttgaaaag cttctcaaaa aagataaaaa gctttcgacg aaagaactca aacagcgcgc 875761 ccagctgcag cttcagcgca agggcttctc atttgatgtt atcagcgcgg cgatggatca 875821 gattgaatat gaaaatgatg aagacacaga gaaagaagcg ctgcgccttc acgcggaaaa 875881 agcgtttaga aaataccgct atgacggctc atatgaaagc gccatgaagg tcaaacaatt 875941 tttattccgc aaaggattct cactcgattt aatcgagcaa ttactgcagg aagaggagta 876001 ctgaaatgga gaaacgatac agtcaaatga caccgcatga actcaatacc gaaatcgcat 876061 tactttctga aaaagcaaga aaagccgaac agcatggaat cataaacgaa ctggcagtgc 876121 tcgaacggaa aattacgatg gcaaaagcat atttgctgaa cccggaagat tactcaccgg 876181 gagaaacata tcgtgtggaa aacactgagg acgagtttac catcagttat ttaaatggcg 876241 ttttcgcatg gggatacagg acctcttccc ctcagcaaga ggaagcgctg ccaatctcag 876301 tattgcaaga aaaagaataa agcgtaacag gaggctgatg atcagcctct ttttgtttgc 876361 agcacattta cacgaattct taaagaaaaa atcattgaat tcacttgaaa aatcttttaa 876421 gatgaaactc gttgtttttt aaaatcaaag gaggcgatga cgttgagtat caaaaaccca 876481 tctgtaaaat ttattatatt tgttcttatg atttgtacat tttcaatcgg ctatacagaa 876541 tacgcggtga tgggtatttt gacgtcgatt gccaatgact ttcatataca ggtttcatcc 876601 gcagggcttc ttgtcacggc ttatgcggca agcgtttgtt tgacagggcc gctcgtcacc 876661 atcatttccg tcaagcttcc gagaaagcct gtgcttcttg ggctgatggc gatatttatc 876721 ctttccaacc tgatgagcgc actggcgccg aattttgcgg tattggccat ttcaagaatt 876781 ttatctgcgt ccattcacgg cgctttcttc gcgattgcca tggtattcgc aagtgaaatg 876841 gttccgccgg aaaagcgtgc tgcagctgct gcttcaatga acggcggact gacagtggct 876901 ctaatgcttg gtgttccatt cggctcttat ctcggagatg tcctgaattg gagagcggtg 876961 ttttccatca ttacggcact tggtgtcatc ggatttttag gccttatggc tgccgtgccg 877021 aacagaaaac caaaagtgat cccaatgctt atgaatgagt ggggtgtttt taaacacaaa 877081 caagtgctgt tttccttcgc gattaccatt ttaggctatt ccggtgtctt tatcgcctac 877141 acctttatcg aacccatttt gaggcattca gccggattca gcacggttgg cattacaggt 877201 gctctctttg cgtatggatt gggaggcgtt gccgggaatt tctttgctgg aaaggtaccg 877261 ctgcctttgc tgactcggac gatgatcggc gtaatgatcg gtttaatcgg tgttctggct 877321 gtatttcctt acatcgccat ttacccggct gcagccattg tggcaacgtt cctattcggg 877381 gcatgcgcat tcggcacgcc gcctcttctg caaacaaagg tcatttcctc atctgagggc 877441 ggcacaacca ttgccgcagc tgtcagcgta tcagcattta accttgccaa tgcccttggt 877501 gcatggatcg gcggaatgat tttaaacgga acaggctctt attcctggct gtttgcagga 877561 ggtgcgctta tgaccgcatg cggacttgtg ctttctacct tcgcacactt atcagaaaag 877621 aagagcgtct acgaatatca agtcaataaa gggtaaaaaa cagctgcagt gtatgcagct 877681 gttcttcttt accgtttgcc tgaggctctc attctttctt gaggatgctg attgatagat 877741 ccgtcagcac gctttgaagc atagtcgtcc tttgctctcg gttcaccctg aaatttgttt 877801 tcgttttcgt aaggaaatcc tttttcttta tttcggacca tgtcatatcc ccctaggttc 877861 gagatcaaaa agttgcgtct tttcagatga agacgtaagg ttagtatatg gagaacacca 877921 cgtaataaag cgttattttt ttcctgaaga aaggagactg cacacatgaa tatgtacatt 877981 gagaaactga ctaatctgct tctggaaaag aacgagatga tcagctatat acaggcaaaa 878041 acgtgggtgg aattgttatg gagcgatttc gaagcaacct acgcaaaagc cggacacgcc 878101 tatcaaggtg aaaaaatgac tgaaaaaatc gtcacacaat ggattgaaaa ctatggcggc 878161 cagctccacc tttttcaaag ctcccgtaac gacgtgaatg attacttaaa tcaaagcaga 878221 ggccttttgc attaaaaacc tgccgttaac gaccggcagg ttttttcatt ttcttaaaat 878281 taccttaaca ggaagaaatc ataaacaaaa catgtttcac cagcctgtca atcagggaat 878341 accacttata tcttgtcaaa atgcgaggag gagctttata tgaaaaagaa acaagtaatg 878401 ctcgctttaa cagctgccgc aggactgggt ttgacagcac ttcattccgc tcccgcagca 878461 aaagctgcgc cccttcacga catatctgtc agcatgccat catccgatac ttacatcata 878521 aaagcaggaa agctgaatgt ccggactgag ccaaatcatg aaggtgatat tctcggcact 878581 gtatcatcag aacaaaaggt aaaagtcgat aggttcgtaa atgccgattg ggctcaaatt 878641 catttcaaag gaaagaaagc atatatttca actcactttt taatgaaaac cgcaagccaa 878701 gcgaaaacaa cgaaacagac agccttctat acaccgacgc ccgaaaacgg aaaagctaag 878761 cagctctcat ctggaacaga ggtgacaata cttgggtggg gattcagtga aaacggcgga 878821 tttgacttca cttgggcgtt cgtggattat ggcggagtta aaggctatat tcacacaaag 878881 gatttacaaa tgcgataaaa aggcaggccg aggcttgtct ttttgcctat gcatgaaaca 878941 tttcttcttt ctgcacgtaa caatgagaaa ggagatgatg atatgacggg tttagtcggc 879001 ggagggctta tgatcattgc gggcatactg atcaaactgt ttcctcccaa atcgatcaac 879061 agtgtgtacg gatacagaac gagacgctca atgtcagatc aaagattatg gaatgaagcg 879121 aaccgttaca gtgcatcatt aatgatcctg tcaggcttgg tgattgcggg aatgggtttg 879181 ctgctgggat caaacttgtt tattcttcag cttatcctgc tgattgccgc ctgtgtcata 879241 acatttatgc taacggagaa aaggctgaaa atcatgacgc acagtcaagg aggagataga 879301 agtggacgga gttaaatgcc agtttgtcaa tacgaacgga atcacgcttc acgttgcagc 879361 cgcaggacgg gaagatggcc cgttaattgt cctgctccat ggatttcctg agttttggta 879421 cggctggaaa aatcaaatca aaccgcttgt tgatgcgggt taccgggtca ttgctcctga 879481 tcagcggggc tacaatctca gtgacaaacc ggaaggaatt gattcgtatc ggattgatac 879541 attaagagat gatatcatcg ggcttattac gcaattcact gatgaaaaag caattgtcat 879601 cggtcatgac tggggaggag ctgtcgcatg gcatttggct tccacacgcc cggaatatct 879661 tgaaaaactg atcgcgatca atatcccgca cccgcacgtc atgaaaaccg taacgccgct 879721 ttatccgccg caatggctga aaagctcgta tatcgcatac ttccagctgc ccgatatacc 879781 ggaggcatca ctaagggaaa atgattatga tacattagac aaagcgattg gattatccga 879841 ccgtcccgcg ctttttacat ccgaggatgt cagcaggtac aaagaagcgt ggaagcagcc 879901 gggcgcgctg acagctatgc tgaactggta cagagccctc agaaaaggaa gcttggcaga 879961 gaaaccctct tacgaaacag taccttaccg aatgatctgg ggaatggaag accgcttttt 880021 gagcagaaag cttgcgaaag agacggaaag gcattgcccg aatggacatc tcatctttgt 880081 tgatgaagct tcccattgga ttaaccacga aaagccagcc atcgtcaatc agctgatttt 880141 ggaatatctt aagaaccaat aagctaaaat ttctctccat ccgtctgtca taatggcaga 880201 ctttttctgt gcgttttttt tcatagtctg ttttaaacat gacaaaataa cattaaaaat 880261 catgaatgtc accataaaat tgtaacaaaa aacaggttta aacgacttta aaaaaaggaa 880321 tagccttact gaagatttgt gtaaaactcc cctaaggcaa tacttaaaaa gaataataaa 880381 aagaaggtgc cttaatgaag caaggattaa tctcgattat tatcccgtct tacaatgaag 880441 ggtataatgt taaactcatt catgaatctt taaaaaagga atttaaaaac attcattatg 880501 actatgaaat attcttcata aacgacggaa gtgttgatga cacgcttcag cagatcaaag 880561 acttggcagc gacgtgcagc cgggtaaaat atatatcttt ttctcgaaac tttggaaaag 880621 aagccgcaat tttggcgggc tttgagcatg ttcagggcga ggcggttatt gtcatggatg 880681 ccgatctgca gcatccgaca tatttgctga aggaatttat caaaggctac gaagaagggt 880741 atgaccaagt cattgcccaa aggaacagaa aaggggacag ctttgtccgc tcactcttat 880801 catctatgta ttacaagttc attaataaag cggtggaagt cgatttgcgt gacggtgtcg 880861 gtgacttcag attgttaagc cgccaagctg tgaatgcact tttgaagctg agcgaaggaa 880921 accgcttctc aaaaggcctt ttttgctgga ttggctttga tcagaaaatt gtattttatg 880981 aaaatgtcga acgaaaaaac ggcacctcca aatggtcgtt cagcagtctg tttaactacg 881041 gaatggacgg cgtcgtttca tttaatcata agccgctgag attatgtttt tatacaggca 881101 ttttcatcct gctgctttcc atcatttata tcattgccac attcgttaaa attctgacta 881161 acggtatttc tgtgcctggg tatttcacca ttatctcagc agtgttattt ctcggcggag 881221 tacagctgtt aagtcttgga ataataggtg aatatatcgg ccgaatctat tatgaaacaa 881281 aaaaacgccc gcattatttg atcaaagagg cgaatatccc gaacaaagac ctgcctgaaa 881341 cgaacgaatt aaaaagcatg cggcgtctga caaaaatgca ctgaaaatac caagcgccat 881401 tggcagtgct ttttttgcgt gtctattatc ttaaaagcaa gactggagaa ttcatatgaa 881461 aagaaaacat atcatgatct atgcggccag tttgctggtg tccgttctgg cacacgcttt 881521 ttttgtgaaa gaatgggcgg aaggcaggta tatgacaggt ccgggtgacg ggcttgcgca 881581 aatgatcgta tttaaaaaat tattatttga ccaatataca cacgggaatt ttttctacaa 881641 ttattcattc ggacttggcg gcggcacatt cagtcagctc ggctattatt tttctgcgtc 881701 ttttcttttt cttgctgtgt ctgccgctgt ttggctgctt caagccgtcc agctgatcgg 881761 agaaacggat acgctttttt gggcagagtc agctgttttt atcagtattt tcaaattgag 881821 cttgatcatc tttacgtccg cttctgtttt tcattatctt cttaagcaca gggcggcatc 881881 gttcacggga gccgtgttat acggcgtctc aattatttat ttccgtcacg aagcgtattg 881941 ggaatttttc accgatacaa tggtttggct tccgctgctt gtgcttggcg cagaaaaaat 882001 tattagagag cggcgtccgg cgtggtttat cgttgcgtgt tcgctgacgt taatcaacaa 882061 tttttacttt gcatacataa accttatatt catcggaatc tatgtgctgt tcagatggct 882121 gatccgtttg gaaccacatg aagagaaaag atggattcaa atcagattat ttctcgtttc 882181 aggcttcatt tcttttggca tcagtgcggc ggcgtttgtg ccggtagtat acggtttttt 882241 aaacaacctg cgccctccat acagccagaa aatagagtgg ctcaatttcg atgataatat 882301 cttattttcg agccggatca tcattgtgcc ggccgctttt ctgctgtttt tgtttattat 882361 ttctttttac aaaaaccgtg tgtttcgtct ctttgccggg ttgagcctgc tgtttattct 882421 gtttcatttc agtccgtatg cggcaagcgt ctttaacggt ttttccgccc cgcaaaaccg 882481 gtttgaatat gttctggcct ttaccattgc gggagcagct gcggctggtt tgtcacagct 882541 gtctgaattg aaacggaaag aactgctccc ggccgcagct gtcgtcctgc ttctttactt 882601 gtatcatatc caaaggtata agctcgatat atggaagcct gcgaatgaaa gtattctatt 882661 gctcttactc atgacaatcg cagccttgtt tgctgcagct tttgcgaaaa aacgggcaaa 882721 aatggctgtg tacggtataa tcattctttc ttcgctgttt gtcgccaact cctatcaaaa 882781 atacgcgctc tcagaaggcg gcgatttgga cagtgtgaca aaagaatatc ttacaagtga 882841 ggaatacaga gggcgggaat catctgagct catcagacgt ttacagaagg aagacgatga 882901 cccgctcatg agaatcgact ggatgaacgg ggtccgcaat aatacgccaa tcatttacgg 882961 atttaatggc ttcagcgcgt attccagcat tttaaacaaa gatctgctgg ccttctattg 883021 gaatgattta agcatcgata tgggcaggga aagcgtcagc cgttacgcgt cattgggaga 883081 cagggcgaat ttatacagcc tgctttacgg caaatattat atgaccgaaa aaacaaacga 883141 agccagcgtc ccgtacggct tcaaaaagca tttagaaaca gagcattatg cagtttatga 883201 gaatcagtac atgcttccat tcgttaaaac agcggatgcc atatacagcg aaagtgagct 883261 ggaccgattg cccgctcttg cgaaagaaca ggcgatgctg aaaggaatta tattaaaaga 883321 tccatcagga aaaacggagc agacaccaaa accgtccaat ttgatcacca agtcggacat 883381 caccgcaaaa caagcccagt atcaaaacgg gctgctaacc gtaactggag aaaacggagg 883441 agagctgatc atcaccccga aacagccatc atccgctccg ggagactact atgtcagctt 883501 ttatttgaaa agcaaagcaa aagacaaagg atttacatta aaggtaaatg attatgtcac 883561 aacaaggaaa tcgaacaaat cgatctataa aaccggagta aataatataa cggtaagagt 883621 gcctaaatca ggccatatct caatcaatct tccgaaagga acctatgagc tgagaaacat 883681 agcgctctat gaagaaaatt accaaacgct gaaaaacgct gtaatgcaaa ataaaacaga 883741 gaaagcagac aaactgaatt ggaacaaaaa tcgactgacc ttttcctatc atctgtcaaa 883801 agaccagtac atcatgcttc cgatcccata tgaaaaaggc tgggagctga agatcaacgg 883861 aaaaacacag aagatcgaaa aagcggatta tgcttttata ggcttcaagg cgcaaaaggg 883921 agacaatcac attgagctga cttactatcc gccatacttc aaaatatcgg cgatcatatc 883981 tctcgtcagt ctgctgcttg ctgtttttta tataagacgt aaaaagcccg gctctatata 884041 gagccgagct ttaatttttt ctgaagtttt tcttcgctga atatccatcc cgtataggat 884101 gaacgaatcg tgagatcatg gccgatatga acaattgcga caaacggata atggcctttg 884161 ctccgataac gcaggtcgat aaatctcacc tcataatgat ctttaaacgt atccacttcc 884221 caccggtata ccggagaaaa ggacagaaac gccgcgatgt tatcatcctg ctttgccgca 884281 tgcattacat cggtttcagg aacaggcacc cgattaaatg tatccagaat cacgacatgt 884341 ccttccatgc ttcttcctac atagaaagca tgtgctgtcg tcactgcgat tcgccattgc 884401 ctgaatttca tcgttggaga aataataatg ctttcgatct catcatgaat catctcatga 884461 agcttccgtt taattctcag ctgcatgatc aggcgcacca agtagtagcc taccaatatg 884521 atatataagc tgagaaacgt gatgccggga ctcccgcctg cataccaaat cgcgatagct 884581 gccagatggc tgataaaaat aaacggatca aacgtattaa tcagcccgag cgcaacccat 884641 tttttcgaaa acggacgaat ggcttgtgtt ccataggcgt tgaatatatc aacaaagaca 884701 tgcagaacga ctgccagcag tgtccacagc cacaggtgca gaaaatcggc ctgaggataa 884761 aataaataca gaatcgccgg gatgatgaca gaccaaaaca aaacggcggg aattgaatgg 884821 gtaaatcctc tgtgattcct tatataaaca gcattgtttt taagctttaa cacagtatca 884881 atatccggag cctgagagcc cgcaagcgtt gcgatcataa cagcgtgagc cattgccgga 884941 tctgatccga caacaggatc aagcgtcgca ataccgccca gtgcgatgcc cataacgaca 885001 tgtgtgcccg tatccatagg tgacctcctt gcagggtgat cctgcacatt cactttgtaa 885061 gaaattcccc attttcatat acccaatttt taaactgatt caatcgttct catatgtttc 885121 cgctttttct ttattactat ttaatgtaac atattatcgt actgtgccct tagtgtacaa 885181 caaaaaacag tctaaagaaa agcggggcgc gaaagactgg ggagaaacac atatgaacgt 885241 acttgaagac aaattaaaac aaaaagacat acagcaattt cgcgatgatt taatctcatg 885301 gtttgaacga gagcagcgcg ttttgccgtg gagagaggac caagatccat ataaggtgtg 885361 ggtatctgaa gtgatgctgc agcaaacgag agtagagaca gtgattcctt actttctccg 885421 gtttgtagaa caattcccga cagtggaagc gctcgctgat gctgatgaag aaaaggtgct 885481 gaaagcatgg gaagggctcg gctattattc gcgagtcaga aacctgcaaa gcgcggtaaa 885541 agaagtgaaa caggaatacg gcggcattgt tcctccagac gagaaagatt ttggcgggtt 885601 aaaaggcgtc ggcccttata caaagggagc ggtgctcagc attgcctaca ataaacccat 885661 tcccgcggtt gacggaaatg tgatgcgtgt catgtccagg attctatcta tttgggatga 885721 tattgccaaa ccaaaaacaa gaacgatctt tgaagacgcc atacgagctt ttatttccaa 885781 agaaaaacca tctgaattta atcagggctt gatggagctt ggagccttga tctgtacgcc 885841 aaaatcaccc tcatgcctgc tttgcccggt tcagcagcat tgctcagcat ttgaagaagg 885901 cactgaacgg gagcttccgg taaaaagcaa aaagaaaaag cccgggatca aaaccatggc 885961 cgcgatcgta ctgactgatg aagacggaca agtgtatatc cacaaacggc cgtctaaagg 886021 tttgctcgcc aacctgtggg aattcccgaa tcttgaaaca caaaaaggga tcaaaactga 886081 gcgtgaacag ctcattgctt tcttagaaaa cgaatatggc atacaagctg atatcagtga 886141 tctgcaaggt gtagtcgagc atgttttcac ccacctggta tggaatattt cagtgttttt 886201 cggtaaagta aaacaagtgt cggataccag caagctgaaa aaagtaacga aagaagagct 886261 cgaacaattt gcgttcccgg tgtcacatca aaaaatctgg aagatggcag gagaagcagc 886321 cgccatctcg gctgctccgt aaaccattct taatcgtaag agacgcgcgt gccgtggctg 886381 tagtccgctt cattgcgctt cattccgccg cgcgcttcaa tttcttgcgt taattcccgg 886441 tattttgatt ggccttcttc gttcaaataa ggcataattt gctgaaaggc atgatgaaaa 886501 taagcgagtt cactgttctt ccaatctttt ttggaaacca tgttcaattc gctcatatca 886561 cgtccgacat acataacaga agaccccctt taaagttctt gccattattg tttgtggaaa 886621 taaaagaact atacgctaca aggagatgag gaaaaatgga acaaaataaa tgtgcactcg 886681 taacaggaag cagccgcggt gtcggaaaag cggccgcgat cagacttgct gagaacggct 886741 ataacatcgt cattaactat gcacgcagca aaaaagcagc attagaaaca gcggaagaaa 886801 tcgaaaagct tggcgttaaa gtgcttgtcg taaaagcaaa cgtaggacag cctgcaaaaa 886861 tcaaagaaat gtttcagcaa attgatgaaa cgttcggcag acttgatgtt tttgtcaata 886921 atgccgcttc aggagtacta agacctgtca tggaattaga agaaacacac tgggactgga 886981 cgatgaacat taatgcgaaa gcattgcttt tctgcgctca ggaagctgcc aagctaatgg 887041 agaagaacgg tggcgggcat attgtcagca ttagttcatt aggctctatc cgctatcttg 887101 aaaactacac cacggtcggt gtatcaaaag cagcgttaga ggctttaacc cgttatcttg 887161 ccgttgagct ttcaccaaaa caaattatcg tcaatgctgt ttcaggcgga gcgatcgaca 887221 cagatgcgct gaagcacttc ccgaatagag aagatctgct tgaggatgcg cgccaaaata 887281 cgccggcggg acgcatggtc gaaattaaag acatggttga tactgtggag tttctagtgt 887341 cttccaaggc tgacatgatc cgcggacaga caattatcgt tgacggcgga cgctcactgc 887401 tcgtttaaaa atttttaaaa aagaggaata gctatacgat cacctgcaca ttctaatgac 887461 cgtggaggtg ataacaatgg ctaactcaaa taacttcagc aaaacaaacg ctcaacaagt 887521 tagaaaacaa aaccaacaat cagctgctgg tcaaggtcaa tttggcactg aatttgctag 887581 cgaaacaaac gctcagcaag tcagaaaaca aaaccagcaa tcagctggac aacaaggtca 887641 attcggcact gaattcgcta gtgaaactga cgcacagcag gtaagacagc aaaaccaatc 887701 tgctgaacaa aacaaacaac aaaacagcta atcactgaaa cagaaaaaag cacttcatct 887761 tcgggtggaa gtgctttttt ctgtttgaaa aacgacaaaa cttgtggaag gtctacagaa 887821 tgagtcaaag ggtttgcttt atggagatcg aaatgattaa aggaggaaat gtttatactt 887881 tcatcaggct gaaggaggaa ccgatgaccg aatttgaaaa gctggtaagt gaacagatga 887941 aaacgatgga taagcttctc gatctccaat cagagctcga ccgctgcaaa caaattgagg 888001 cggaactccg gcatttggaa agggatgcaa ggctgcgtgg gattcaggct gaaattgcgg 888061 taaaacggaa acaccttgcc gatatacagg atatgtttca aaagcagaca gagcaggtca 888121 ttcgttcata tcgcagctca gaaaagccgt cttcctttgt gtagtgcagg aatgtgccat 888181 tccccggccg gaatggctct tttattttca tttttcaatt tgtaacgtta taataggtaa 888241 aagacgttgt cggtaagcaa atttggacat actaactgta gggctttata gaaagtaggg 888301 gagaaatatg ggctatccca aggaaggaga aaccattcaa attcacagct ataagcacaa 888361 cgggctgatt catagaattt ggaatgagac aacaatctta aaaagtacag aaatgtgtgt 888421 catcggagcc aatgaccgga cgatggtaac cgaatcagac ggccggacat ggataaccag 888481 agagcccgca atctgttatt ttcacgcaag acaatggttt aatgtcatcg ggatgctgag 888541 ggaagacggg gttcattatt attgcaacat cagttctccg tttgcctatg atggcgaagc 888601 aattaaatat attgattatg acttagatgt taaggttttt cctgacatga cctacaatat 888661 tctcgatgaa gacgaatatg atgatcatcg gaaagccatg aattatccaa aagaaatcga 888721 cagtatttta agagactact taaatacgct gctccattgg attcaccagc gtcagggacc 888781 gtttgcgccc gagtttgtcg atatgtggta tgaacggtat ttgcgctata caaaataatg 888841 gttacgtaaa aacctgttgc ggggtacaac aggtttttca catgggctca cacacatcat 888901 gataaagaga gagggggaat caaccgtggg ggttatgaaa cgctacatgc aattcgtcaa 888961 accttataag aagcaaattt tcgttacagt gttaatcggg atcgtaaaat tctccattcc 889021 gcttgctctc ccattgcttc tgaagtacgt agttgacgac attattcaag gaggcggcac 889081 ggccagtgac aaaaccacgt cattgttcac gattatggcg atcatgttcg ccttattttt 889141 aattttgcgc ccgcctgttg aatattaccg gcaatatttt gcccagtgga ctgccagcaa 889201 ggtgctttat gatataagag ctaagctgtt tgaccatata caaaaactga gccttcgttt 889261 ttacgcgaat acaagaacag gggaagtcat ttcccgagtg attaatgatg tagaacaaac 889321 aaaggatttc gtcatcacag ggctgatgaa tatatggctc gatatgctga cgattttgat 889381 tgtaatctct atcatgctca cactggacgt taaattaacg ctgatctcta tcgttttatt 889441 cccattatac ggaatatcag tgaagtattt ttacggccgt ttacgaaagc tgacaaggga 889501 gcgctcacag gctcttgctc aagtgcaggg gcatttgcat gaacgcattc aaggcatgcc 889561 tgtcatcaga agctttgcga tagaagatca tgaacaggct caatttaatg agaaaaacgg 889621 tcatttctta gataaagcca tccgccacac gaattggaac gcgaaaacct ttgcggtcgt 889681 taataccatt acagatttgg cgccgctcat cgtcatagcg tgcgccgggt attttgtcat 889741 taatggaccg ctgacagtcg gaacaatggt cgcgtttgtc ggatatattg acagaatgta 889801 caaccctgtt agaaggctga tcaattcctc tacaactttg acacagtcaa tcgcatcaat 889861 ggacagggtg tttgaattta ttgacgagcc ctatgaactc actgacaaac caaatgcgat 889921 aaaggccgat cagattcgcg gaggagtgga gtttcaaaac gtttcgtttc aatatgagaa 889981 ggacaaagaa aatattcttc atgatgtatc cttaaaagta aatagaggag aaactgtagc 890041 tctcgtcggc atgagcggag gaggaaaatc aacgctcgtc agcctgatcc caagatttta 890101 tgatgtaaca agcggcagac tgctgattga tgggacggat attcgcgatt atgaagcaag 890161 aagccttcgc aaccaggttg gtatggtgct tcaagatacc tttttattta gtgaaacgat 890221 tcgggaaaat atcgcgatcg gcaagcctga tgccacactt gaagagataa tcgaagccgc 890281 caaagctgca aatgcccatg aatttatcat gagttttcca gaaggatatg agacccgggt 890341 gggggaacga ggcgttaagc tttcaggcgg acaaaagcag cggatctcaa ttgcgcgggt 890401 attcctgaaa aatccgccgc tcctcatttt agatgaagct acatcagctc tggatttgga 890461 aagtgagcat tacattcaag aagcgatgga caaactggcg aaggatagaa caacttttgt 890521 tgtcgcccac cgtttatcga caatcaccca tgcggataag attgttgtca tggaaaacgg 890581 gacaatcatt gaaatcggaa cccatgatga actcatggac tatgagagcc aatacaagca 890641 cttatttacc attcaaaatt tgaactaaaa catcaatctt atatcctttt aacgaaggat 890701 ataagatttt tttgtatata aaaaaacccg gctgtttaac cgggttactc ttctgtttct 890761 atttcgcagt ctttcggatg atacgtttga aaacttgtga taagtgtttc taaatgttca 890821 agctgctcgc gatattccac ggcgcttgcc ataatattga gcatgttgta atcaataagc 890881 tcctcatccg tattctgctg attttttaaa aatgactttg ttaaaagctg cttataccgg 890941 atgccttctt caaccgcgtc atcatgcggc ttgatttttc cgacaaacct catcaaaatc 891001 cgctcgtgcc agtaaagcag gtaatcaagt tcttcagtca atgtttcctg aaactcttcc 891061 ggcatatgat agatctcgtt ttccagacga tgcagcttct tcaatgtatc aagcgcccga 891121 tttgcagtaa taatggcctg tctgaacagg acaagctttc ttgatttcac ataagtcgtt 891181 ttcttaaagt aacttctttc ttctttatat agaagatatg tctgatcaag cttgatcatt 891241 ttttctttca gtttttcaat atcctctttc aaaatcgaat gctctgtcga ctgccgcatg 891301 gacaatctga tccacttcat aatttcttcg gtgttttcga cggtattatg aatcagcttt 891361 gtttcgtact taggaggcaa aaacacaagg ttgacgataa aggaagaaag cacccctaag 891421 atgactgtgc ttgttctgat cagcgcgaac attaaaaagt cgtcaccggc agattctaat 891481 atcgcaatga ctgttacaag agcaattgaa attgtatgtt caattttaag tttcagcatg 891541 attgtaatga caataactgc tgttaacccg atcataatcg ggctgggtcc gaaaataagg 891601 ccgaacactg tggcaatcac agctccgatg atatttgctt gaacctggtc aataataatg 891661 agaaaagagc ggtaaatcga cggctggatc gcaaatatcg ctgcaattcc agcgaaaatc 891721 ggcgcgggaa gcccgatcca cgaagccaaa taaagggcaa gtgtaatcgc aatcccggtt 891781 ttgaaaatgc gggcaccaag tttcattggt ttgtgcgtgc attcctttct atagtaaatt 891841 gtgtgacata gcaaatgggc taatccttaa aattcccggt tagtttattt gctaaacaat 891901 taagtaatat acagggatcg atacaaatat tcaagctatt tttctagaaa aagaccaaaa 891961 tcttacacgc tgtttgattc cataaaaaaa caggagctca aagctcctgt tcaaggtatt 892021 tgattctagt tttttagatg tttaaatgca tcctcgaccg ctgtaagcgt gtctttaata 892081 tcctgctctg tatgtgctgt ggtaataaac caagcttcat acttagaagg tgctaaatta 892141 attccgcgtt ccagcatcag cttgaaaaac gtagagaatg tttctccgtc actccgttca 892201 gcctgctcgt aattttccac tttctcatca gagaagtata ccgtgagcgc accttttaac 892261 cggttgaccg taatggtgat gccgtgtgtt tctgcgtgct tcaaaatgcc ttcctcaagc 892321 atagcgccaa ggtgatcaag cttttcatac acgccttttt ctttgagcac ttccagacaa 892381 gcgatgcctg ataggatgga agcggggttc cctgccattg ttcctgcctg ataagcaggc 892441 cctagcggag ctacctgctc catgatttct tgtttgccgc cataggcccc aatcggaagt 892501 ccgccgccga taattttccc gagtgctgtt aaatctggtt tcacctgtaa gagatcctgc 892561 gcgccgccat acataaagcg gaaagccgta atgacttcat cgtaaataac gagagcccct 892621 gcattatgtg ttaattcatt tacttgttct aagaagccct ctttcggctc cacgataccg 892681 aagttgccga caatcggttc aacgagaacc gccgcgattt cactgcccca tttttcaaga 892741 gctgctttat agctatcgat atcattaaat ggtactgtga tcacttcgtt tgcaatgctt 892801 ttcggtacac cggctgagtc tggtgtgccg agagtagacg ggccggagcc tgcggcgaca 892861 agcacaaggt ccgaatgccc gtgatagcag cccgcaaatt taatgatttt tgtccggcct 892921 gtatatgcgc gagccacgcg gatggtcgtc ataacggctt ctgtacccga attgacgaat 892981 cttactttgt ccatagcggg aatggcttct ttgagcattt ttgcaaatgt aacctcgtgt 893041 ttcgttggtg ttccatacaa tacaccgttc tctgctgctt ttttaatcgc ttctgtaata 893101 tgcggatggg catgtcctgt aataatcgga ccgtacgccg ctaaataatc gatgtatttg 893161 ttgccgtcca catcccaaaa ataagcgccg cttgctttct ccattgcaac aggagaaccg 893221 ccgccgactg ctttatatga tctagacggg ctgtttacac cgccgacaat gtgctgtaat 893281 gcctcattgt gaagttcaat tgattttgta tgcaagaata aaaacctcct atatctccat 893341 gcgtcctttc tattgtagca tgcttccgaa caagaacaat ggcttcgggc ttcagattca 893401 gctgagatgg ttgtaatctg gacaagaatt ggatacgctt aataaaaaaa catccggagg 893461 taacgtaatg actatagaaa tcggacaaaa agcgcctgat cttgagttaa aaggtgatca 893521 tggggaaaca gtaaaattat cggattataa aggaaagtac atcgtgcttt atttttatcc 893581 aaaggacatg acaccgggat gtacaactga agcatgcgat tttcgggaca gtcacgaaag 893641 cttcgccgaa ctggatgccg tcattatcgg cgtcagcccg gacagccagg aaaaacacgg 893701 aaaatttaaa gagaagcata accttccatt tctgcttctt gttgatgacg agcataagct 893761 ggcggaagca tttgatgtgt ggaagctgaa gaaaaacttc ggaaaagagt atatgggaat 893821 cgagcgttcc acttttttaa ttgataaaga aggccggctc attaaagaat ggagaaaagt 893881 aaaagtaaag gaccatgtag ccgaagcgct tcaaaccctc aaagatatgt ctgaaaagta 893941 aatctctatg agcctatgct tacttttacc ctgatatcaa ttgacaaatt atcgtagaaa 894001 gagttacact aattataaac attacaatgt aagaattttt tttagaagag aggtgcatga 894061 cggatggctg cacatgaact aaaagaagcc ttagaaacgt tgaaggaaac cggagttcgc 894121 attactcctc aacgtcatgc gattctggaa tatctcgtta actctatggc tcatccaaca 894181 gcggacgata tatataaagc tctggaaggg aaatttccta acatgagcgt agcgacggta 894241 tataacaatt tgcgtgtgtt ccgggaatca ggtttggtaa aagagctcac atacggtgat 894301 gcttccagca gattcgattt tgtcacatcc gatcactatc acgcgatttg cgaaaactgc 894361 ggtaaaattg tggacttcca ctacccgggc cttgatgaag tggagcagct cgctgcccac 894421 gtcacgggct tcaaggtaag ccaccaccgt ttagaaattt acggcgtctg ccaagagtgt 894481 tcgaaaaaag aaaatcatta aaaataagct gaccgcacga aacggtcagc ttattttatt 894541 tcgacatttt ctttttatta taagactcat caaattcttt tccttctaat cccttatcta 894601 aagtcagcgg ctctcggcaa tgcatgcaca tatcgactac tcctaaaacc tttgtctctt 894661 tatcacagcc tggacaaatg acgcgaaccg ctttagtcga aagcattccg atccaaaagt 894721 aaactaccgt gctgagaccg atggataaaa gcccaagtat cataaacaaa ctagaaagca 894781 aaactgactc tttgaaaaag atcccgatgt acataatgat aaacccaacg aaaaccaaac 894841 ttaacgcaaa tgttctgatt ttattaattt tgctggagta tttcgccatg tccatccccc 894901 tctgttttaa ctatagcaca aacccgatgg gattttcttc atgttttcgg ttgaactgga 894961 atttacatat ggagagttac tgtgaaattg tttataatag ttcaatgtgt ttagaaaaaa 895021 ggaatttcgt tttaaccata gaattgaatc aaatagagaa taaaaaaatt tgaacaattg 895081 cattggagga atagtgatgg aaaatcttct ccgtccaatt taccaagaaa gagcaagtca 895141 ccccaataca ttggctgtca ttatgattga gagaagaaac aaaacatctt ccttaacaga 895201 taactttgat gcagctttgc tggtgattgt aaaggatgct gatgagccag tttttataaa 895261 gcattatgaa tttgatcatc aaacagcttc tttgcatgtg gtaacagatt ctcagattca 895321 agaatggatt ttgcttggaa caaatagaag aatcatagat tggattgtaa atggcagagt 895381 cttgtttgac cgtaatgaat acgtagttga actgattgac aggctgaata catttccgtt 895441 tgccgaacgt aaactgaaga tcggactcga atacggcaaa ttaatcagaa ggtatgttga 895501 agggaaagct ttttttgaag ccaatcaatt tttagatgcc tacaatgccg ttgttcatgc 895561 gctgcatcat ttagcacgta ttgaagtaat cgacagagga ttccatcccg aaaccacggt 895621 gtggagccaa gtgcgccaga tggagcccca agtgtacaaa ttatattccg agctgattga 895681 aagtcatgag agcctggaaa aaagacttga attattattc ttagcaaatg attttctcat 895741 ccattccaaa gccgagatcg gttcggcgca tcttttcgaa gtaatgaaag aaaaagacat 895801 ttggcaattc ggtgagcttc ttcaacatca tgacctaaag cactttaccc aagatcttgg 895861 cgttatgctt gattacttga cggaaaaggg acttatcaac gtctgccaga tagaaacgaa 895921 aggacaggct gtctatcacc gaggatattc ttttaaaaaa ggtgttgact ctgattcttg 895981 accgtgttat attattaaac gtcgctgatg cgcttctgag aaaacaagct cacagcggcg 896041 ggaaaataaa tcaaaaaaac atttgacaaa agaaagtcaa aatgttatat taataaagtc 896101 gcttcaacaa gaagtgaaaa tgatctttga aaactaaaca agacaaaacg tacctgttaa 896161 ttcagttttt aaaaaatcgc acagcgatgt gcgtagtcag tcaaactagg gcctgcacga 896221 cgcaggtcac acaggtgtcg ccgcaggatg cggtgaactt aacctgtgat ccatttatcg 896281 gagagtttga tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag 896341 cggacagatg ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta 896401 acctgcctgt aagactggga taactccggg aaaccggggc taataccgga tggttgtttg 896461 aaccgcatgg ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc 896521 gcattagcta gttggtgagg taacggctca ccaaggcaac gatgcgtagc cgacctgaga 896581 gggtgatcgg ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag 896641 ggaatcttcc gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt 896701 tcggatcgta aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct 896761 tgacggtacc taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta 896821 ggtggcaagc gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc 896881 tgatgtgaaa gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc 896941 agaagaggag agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac 897001 cagtggcgaa ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc 897061 gaacaggatt agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg 897121 gtttccgccc cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg 897181 caagactgaa actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta 897241 attcgaagca acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata 897301 ggacgtcccc ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt 897361 gagatgttgg gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag 897421 ttgggcactc taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat 897481 catcatgccc cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc 897541 gaaaccgcga ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa 897601 ctcgactgcg tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg 897661 ttcccgggcc ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg 897721 tgaggtaacc ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt 897781 aacaaggtag ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg 897841 gaatataaga ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga 897901 tcattccttc gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaattag 897961 taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg gcgcacggtg 898021 gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc ttcggggagc 898081 tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc gtaatggagt 898141 ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact gaaacatcta 898201 agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc gaaacgggat 898261 tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg gagttacaaa 898321 agaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca gccctgtagt 898381 caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga aattccgtcg 898441 gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata gtgaaccagt 898501 accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg 898561 tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg 898621 gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg aaagcgagtc 898681 tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta cccatgtcca 898741 gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga aaagtgcggg 898801 gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg ttctctccga 898861 aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg attggactag 898921 gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact tatccttggg 898981 agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga ccgccagcta 899041 aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca accaggatgt 899101 tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg agtgactctg 899161 cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc ttcgaacagt 899221 ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg agcgcttaga 899281 agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac cgaatgccta 899341 aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa 899401 ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca tttgagcaat 899461 ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca agcagttagg 899521 ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag cgaaatatag 899581 tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga gaggtgcccg 899641 taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag agaactctcg 899701 ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct gttagggtgc 899761 aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa cacaggtctc 899821 tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga aggttaagag 899881 gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat 899941 aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca 900001 acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca 900061 ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg 900121 ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca gcttcggtgg 900181 aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc ccttatcggg 900241 cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg 900301 aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta aaggcacaag 900361 ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt agtgatccgg 900421 tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg ataacaggct 900481 tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc ggctcatcgc 900541 atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag cggtacgcga 900601 gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg caggaaattt 900661 gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt gtaccagttg 900721 ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg aaagcatcta 900781 agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag atccctgaaa 900841 gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct gacagatact 900901 aatcgatcga gggcttaacc atatttttga atgatgtcac acctgttatc tagttttgag 900961 agaataagtt tttcaaaaaa acacttgatt ttctcaagaa tacatagtat aatgttaaat 901021 gtcactgaaa ttgtctggtg atgatggcga agaggtcaca cccgttccca tgccgaacac 901081 ggaagttaag ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggaca 901141 tcgccaggca gacttcattc cgcagtagct cagtggtaga gctatcggct gttaaccgat 901201 cggtcgtagg ttcgaatcct acctgcggag ccattattgg agagctgtcc gagtggtcga 901261 aggagcacga ttggaaatcg tgtaggcggt caactccgtc tcaagggttc gaatcccttg 901321 ctctccgcca ctgatactta tacataatta caattgaaag tctgggcccg ttggtcaagc 901381 ggttaagaca ccgccctttc acggcggtaa cacgggttcg aatcccgtac gggtcattat 901441 atgatggagg attagctcag ctgggagagc atctgcctta caagcagagg gtcggcggtt 901501 cgagcccgtc atcctccacc attatatcat cgcggggtgg agcagttcgg tagctcgtcg 901561 ggctcataac ccgaaggtcg caggttcaaa tcctgccccc gcaaccaaat tttaaaatgg 901621 tccggtagtt cagttggtta gaatgcctgc ctgtcacgca ggaggtcgcg ggttcgagtc 901681 ccgtccggac cgccatttga atacttaggc tcggtagctc agttggtaga gcaacggact 901741 gaaaatccgt gtgtcggcgg ttcgattccg tcccgagcca ccacctatgc cggtgtagct 901801 caattggtag agcaactgac ttgtaatcag taggttgggg gttcaagtcc tcttgccggc 901861 actgtttttt caaaatttaa tgtggagggg tagcgaagtg gctaaacgcg gcggactgta 901921 aatccgctcc ctcagggttc ggcagttcga atctgccccc ctccaccatt tataggggca 901981 tagtttaacg gtagaacaga ggtctccaaa acctccggtg tgggttcgat tcctactgcc 902041 cctgccaaat ttatgacatc ttgagattat ggcggttgtg gcgaagtggt taacgcacca 902101 gattgtggct ctggcactcg tgggttcgat tcccatcaat cgccccatat tatcattggg 902161 ctatagccaa gcggtaaggc aacggacttt gactccgtca tgcgttggtt cgaatccagc 902221 tagcccagtc tcacttttta tatcaactgc atataatgta ttaagtccat taaaaatgcg 902281 gaagtagttc agtggtagaa caccaccttg ccaaggtggg ggtcgcgggt tcgaatcccg 902341 tcttccgctc caattacggc ggcatagcca agtggtaagg cagaggtctg caaaaccttt 902401 atccccggtt cgaatccggg tgtcgccttc ttattgccgg ggtggtggaa ttggcagaca 902461 cacaggactt aaaatcctgc ggtaggtgac taccgtgccg gttcaagtcc ggccctcggc 902521 accaatttta cttacatggt aagttgaatt ggtgtttgtg ttttatcatt ataactaatc 902581 atattaatga tctacataag tagatcattt ttttaatgct ttgatttatc ataacaagtt 902641 aagttccgag gcctattata aagcggctgt atagctagtc tttcaacact tttattttat 902701 atttccataa aaactttttt gaaatacgtt gacactttat gagatccatg atatatttat 902761 attcgtcggt tagatacgac gtaaaacttg ccggtgtggc ggaattggca gacgcgcacg 902821 actcaaaatc gtgttccttc tggagtgtcg gttcgacccc gaccaccggt atactgaaaa 902881 acccgtttct taacagaaac gggtttttat tttttattaa agaaaaggag cctcggctcc 902941 tttttatact tactcagcgt attggtctag gatctcttct agcacctctt ctagctcttc 903001 tgtatcttca agctctgatt ggctgaaacg gacgcgtaca agctgttctc cgtcattata 903061 catctcttcc aaccaccctc ggagtcctct tgctctgcgg tcgacttcga aaatgatttc 903121 caaaccgtct tcgtctaaaa ggaaaatgag ctctaattca tcaagcatct gacgataata 903181 tccggaagtc ggaacgaatt cgaattcttg aacgaacgga agacgacgct ggaagtaggg 903241 cgcttgttcg cagtctgctt cgttaagacg gaagcccagg ttttcgattg cttcaagcac 903301 attttcaatc caagggtgcg cttcaacgaa aatgcggtca tgatcggatt tatcgatacc 903361 gccttgaatg tcaaggtctg tcaccacggc aacctctact ttccctacag tgatcggcgt 903421 atctagaggc agagtgaatg tgaacggaaa ttgatgctct tcaccaggct gtatggtaaa 903481 tgaaccagtg acccggaaag aatgaattgt agcgtatttc cggtgctctt catcgtcttt 903541 tacaatgaca taccgtgtgc taagctgtaa atcgatataa cggatgtcct gagcgatttt 903601 tccgcctttg acatgtaccg ttccctgtac ttcttctcct ggaaaatatg cgtctttttc 903661 taaaattgta tctacttttg cagctccaat tccggcactt gccgcaagct tcttaaaaaa 903721 tgacatgtta gatcttcccc tttttctttt ttctcaacag atatacgtaa gaaggaggaa 903781 aaaagattcg tttgattcat acttttttcc tattattcgt ctcggcctag ggacagacta 903841 agaataatat tgaaaataaa ggagtcgatg gaagtgaata aagaaagttt ggttgcagat 903901 gaattacaca gaatgttttt ggctggtgag ctgcaaatca cagtagagga ggatataaac 903961 aatatttccg aaaggctgag aaacggcgat ctcagtttag accgattaag cggtgaagac 904021 gtgtttataa aagaaacggt aaatgaggct ttaagaagag tggagcaata aaaaagagac 904081 ggcatctcat ctttgagatc ccgtctcttt ttgtggtctt tgctgtaaga taaaagcgaa 904141 tcgatttgga attgctcacc cgagccaccc cttttctaac agaagatctg acagttcatc 904201 atggagataa acagctgtat ctaattgatc atgcaatgct cttctgatgt ggggattttc 904261 ggttgctgtt gttgcgacag tgtatttgtt aatgctggtt tttattgttg ttaacaaatc 904321 aagaatatct ttgggacaaa gactttgttc aatgggaaac cacctccttt gtttttttag 904381 cagctcctga taagaaagta tttgactttg tttcttgctt ctatacaaaa tgctataata 904441 agcaacaaat tttgttgggg ggtgtgatga tgaagcagat tattgcgatg gggggcgggg 904501 gtttttcgat ggagccggat aatttgtccc tcgatcaata tatcctcaat caatcaaaac 904561 gagagcagcc tcgtatttgt tttttgccga cggcgagcgg agattcccaa aactatattc 904621 agcggtttta tcatgcattt caaacattgg attgcgtgcc gtctcattta tctttgttta 904681 agccaccatc atcagattta gtttcttttg ttatggaaat ggacgtgatt tatgttggcg 904741 ggggaaatac gcggaattta cttgtgttat ggaaagagtg ggggctggac catattctca 904801 gggaagcatg gaagaacggt gtggttgtag ctggaataag tgccggtgcg atctgctggt 904861 ttgaagaagg ggtgacagat tcagccggac cgctgacaag tttgaaaagt ttaggttttt 904921 tgcaagggag cttttgtccc cattatgacg gggaaaagga tcggagaccg gcataccacc 904981 agctgatatc taacaagttc ttatgcagtg gctatgcagc ggatgatggg gctgctctcc 905041 atttcataaa tgatcagctg tttcagactg tgagttcaag gtcgggtgca aaggcatatc 905101 gggtgatgat ggctgaacat gaaatagctg aaatcccgtt gccggtcaaa tatttagggt 905161 gaaattggct gaatattatc tatattcctc tttttttcag attgatttta tgataagatg 905221 agtgcgaaat caatagttac tgggggtgcc cgctttcggg ctgagagaga aggcaagctt 905281 cttaaccctt tggacctgat ctggttcgta ccagcgtggg gaagtagagg aattgttttt 905341 gttattgtct tgctgggcaa taatatgttt ctttctgact gtaaccgggt tcatttatat 905401 gaatccggtt ttttgtgctg gttatgggct tgattttgtc ctttcaaacg tagaaagggg 905461 aaggaaaagt aatgcaaaac aattcagtgc agcaagccaa catttccatt atgtcaagtt 905521 tttcaggcag caagaaggta tacgtggagg gttcttcttc ggacatccaa gtgccgatga 905581 gggagattgc attgagtccg acgacgggat cgttcggcga agaggaaaac gcgcctgtgc 905641 gtgtctatga tacaagcgga ccgtatacgg accctgaagt aaccattaat attcaagaag 905701 gattaaagcc gctccgccaa aaatggatca cagagcgcgg tgacgtggaa gagtatgaag 905761 gtcgggctat aaaaccagaa gataacggtt ataaaaaagc aaaaccaaac gtaagctatc 905821 caggattaaa gcggaaaccg ctgagggcga aggcaggtca aaatgtcaca caaatgcact 905881 atgcaaaaaa ggggatcatt acacctgaga tggaatttat cgccattcgt gagcatgtgt 905941 ctcctgaatt cgtcagagac gaggtagcca gcggccgggc gattattcct tcaaacatta 906001 atcaccctga aagtgagcca atgattatcg gccggaattt tcatgtgaag attaatgcaa 906061 atatcgggaa ttcagcggtt acgtcatcca ttgaagaaga agtggaaaaa atgacgtggg 906121 ccatccgctg gggagcggat acgatgatgg atctctctac cggaaaagat attcatacga 906181 cgcgtgaatg gattatccgc aattgccccg tgcctgtggg aactgttccg atttatcagg 906241 cgcttgaaaa agtaaacggc gtagctgagg atttaacgtg ggagatttat cgtgatacgc 906301 taatcgagca ggcagagcag ggagtggatt attttacgat tcacgcgggt gttttgctta 906361 ggtatgtacc gctgactgcc aaacggacaa ctggtatcgt gtcacgcggg ggagcgatta 906421 tggcgcagtg gtgtctggct catcatcaag aaagcttttt atacacacat tttgaagaaa 906481 tatgtgagat tatgaaaatg tatgatattg ctttctctct tggggatggt ttgcgtcccg 906541 gatcaattgc tgatgccaat gacgaagcgc agtttgctga attagagacg cttggagagc 906601 tgacgcaaat tgcctggaag catgatgttc aggtgatgat tgagggtcct ggacatgttc 906661 cgatgcataa aatcaaagag aacgtcgata aacaaatgga catttgtaaa gaagcgcctt 906721 tttacacatt ggggccgttg acaacggata ttgctccggg atatgaccat attacttcag 906781 cgatcggagc ggcgatgatc ggttggtacg ggacagcaat gctttgttat gtaacgccga 906841 aggagcattt ggggctgcca aaccgtgatg atgttcgtga aggagtcatt acatataaga 906901 tcgctgcgca cgctgcggac cttgcaaaag ggcatcccgg agcgcaaatc cgggatgatg 906961 cgttatcgaa agcccgtttt gaattccgct ggcgggatca gtttaattta tctcttgatc 907021 cggagagagc ccttgaatac catgatgaaa ccctgcctgc tgaaggagca aaaaccgctc 907081 acttttgttc catgtgcggt ccgaaatttt gcagcatgag aatttcacag gatattcggg 907141 attatgcgaa gaaaaacgat ctcagtgaag cagaagccat aaataaagga ttaaaagaaa 907201 aagcaaaaga gtttgtcgat acgggaagca atttatatca ataaaaaaaa tgaagatgga 907261 gaatgctcca tcttcatttt tttagaaaaa cagagagcgt cgaagcggag gaatactctg 907321 ttcaaagcgg aaaacatttt ctggatcata tgtcgttttg acacggcgga gtcgttcaac 907381 gttttcgccg taatatgttc ttggccagtt tctgatttcg atatctggcc aatttacgta 907441 gtctcccatc gtttctttcg aaagggacgt tctcagcccc tcaatccagc ggacattttg 907501 tcttttttct ccaggggatg tccagtttgt taagtattcc tgggcgatga ttgcgtcacg 907561 ataataaaat gccgtttggt cgggagcgac ccgtccggct gccccgccga gtgcttgctg 907621 ccagacactg gcgttttgat tcggagcgtg ctctaaaaag tgttttattg ttgagatcgc 907681 acgttctgat aatggctttt caatgaaaga gccggagcgt ttcatttttt gaggctgatt 907741 gcctcccggg ctgttaaaaa aggttaccgc ttcaatgaat ggcgttgttt ttaccattcc 907801 gcttgtcgga cttcctgctt tcaataaagg ctttaacagt ttttttaact ctgtttttgg 907861 cccgacaaat tggccgaggg cttctatgcg gtttacttct ttaggccaaa actctattga 907921 tgatgtaagc cggtcatctg tatacggggc ccagttctgc cacgtgttat atacttcctc 907981 aaaatcatcc catccccatg taatagaaaa aatcgacact tgagagatgg gcactgcttt 908041 aaatgtcatg gaggtgacta tgccgaaatt gcctcctccg cctccctgag acgcccaaaa 908101 taagtctgga tgatttgaac agctgactgt aatcagatca gcgccctctt tttcgtctgc 908161 tacgatcatc tcaagctgca cgaggctgtc gcaagtaaga ccggcagccc ttgttaaaag 908221 tccaattccc cctccgagag ttaaacctgt gagccctaca ttagcaatgg tgcctgcggg 908281 aagcgtcagg ccgtattgcc agagtgtccg atagacttct cccaattcag cccccgcttc 908341 aatataggcc agctttttat cctgattcac agttattttt ttcatctcgc ttaaatcaat 908401 aacaagaccg ttatttaaaa gggaaaagtt ctcatagctg tgtctgccgc ctctaatacg 908461 gaaaggcaca cggttttcac gcgcccattt cagcgcattg agtgcatcct gtttgttttg 908521 gcaaaacaca atgatgtcag gatacctttc taagcttagg ttaatattgg ttcttgcttc 908581 gttatagtcc ggatcatccc gtgtcacgat acgtccggtc aattttgtct tttccacact 908641 cccacatctc tttctctcgt attctagttt ctctagctta tgcgtcaggg gaaaagagtg 908701 tataaggaaa aagcggggat gcaatctgat acagtgtcaa caccctcaaa aaatagttga 908761 caggtcggta ttgtatgaat taacatggtc agtacaaatt tttcaaattt atcgcgctga 908821 tcggaacacc gaaggctctt atcgtttaga taagggcctt ttttgtatga aaaagggggg 908881 attattgatg ggagtcaaaa aagaaaaggg gagaaaacga ttcaggaagc gaaaaaccta 908941 cgggaatcag attttgccgc ttgagctgct gattgaaaaa aacaaacgag agattataaa 909001 cagcgcggaa ctcatggaag aaatttatat gaagattgat gagaagcata cgcaatgtgt 909061 aactaaatat aaaaaaaccc gctgactaca acgggttttt gcatttctcc attaagaatc 909121 ttttttaatc ggcaatccaa ggccttctgc cacgcgtttt ccgtattcag gatccgcttt 909181 gtagaagtgc tcgatttggc gcagcttgat ttcttctttt tctaccggct tcatggcatt 909241 aacgatattt tcaacaaggc gggtacgttc atcttcactc attaaacgat acagatcgcc 909301 ggcttgagtg tagtgatcgt agtgatcgta gcttacgctg tcagcgatac cttgtaccgg 909361 atatgctgct tgcttatcct caggtgactc ttttggaccg ccgaagctgt taggctcgta 909421 atacacagat ccgccgccgt tatcatcaaa acgcatttgc ccatcacgct gataattgtt 909481 tactttgttg cgtgcgcggt tgattggcag cgcttgatgg tttgcaccga cacggtagcg 909541 gtgtgcatca tgataagcaa aaagtcgacc ttgaagcatt ttatccggtg aaacatcaat 909601 accaggcacg agggttccag gtgaaaatgt cgcttgttct acctctgcaa agtagttttc 909661 cggatttctg tctagaacca tgcgtccgac ctcgattaac gggtagtctt tttgagacca 909721 aacttttgtg acatcaaacg gatcgaaacg gtacgtattt gcatcttcta aaggcatgat 909781 ttgcacatat agtttccatg caggataatc accgttttcg attgcgttga aaaggtcttc 909841 tgtatggtaa tcagggtttt caccggcaat ttttgctgcc gtattgacat caaggttttt 909901 cacgccttgt tctgttttaa agtgatattt aatccatacg ccttcgcctt cggcatttgt 909961 ccatttgaat gtatggcttc cgaagccgtg catgtggcga agtgtcgcag gaattccgcg 910021 gtcagacatc aggattgtca cttggtgcag tgactctggt gaaagtgacc agaaatccca 910081 tacagccgta gggtttttca ggtgtgtttt tggatctctt ttttgtgtat ggatgaaatc 910141 agggaactta atcgcatcgc ggataaagaa tacaggcgta ttgttgccga cgatgtcgta 910201 gtttccttct tcagtataaa atttaacagc aaatccgcgc gggtcgcgaa ctgtgtcagc 910261 agagccaagt tcaccggcaa ctgttgagaa acggatgaac aacggtgtgc gtttgccgac 910321 ttcagaaagg aaagcggctt tcgtgtattt tgttacgtcg tttgtcactt caaaatatcc 910381 gtgtgcgcct gctcctttgg cgtgaacaac acgttcagga acacgttctc ggttgaaatg 910441 ggccaatttt tcgagtaaat gtacatcttg aattaaagtt ggtccgcgag aaccggcagt 910501 cattgagttt tgattatctc caaccggagc gccccagcta gttgtcagtt tatttgaact 910561 catgttatca cctcttggaa tttataagaa cataatatca tctctaagta aaaagtcaat 910621 attattttat aattattata aaatagttat ctctattaat cgatatatag tatcgaaatt 910681 gttgaaaaac cttgttgtaa cagcttttta tgacacttaa taatttttgg agaaataatt 910741 tttccttctc tatttgcgaa acaagcagag taagtgataa acaaggatat caaaaatcgt 910801 atttaaaaaa gagttgacat atcggaataa tttgaattaa catgttattc aaacaaaaaa 910861 acaattgggc agctgatcgg accgccgaag gctctcatct ctacaagaac agagatgggg 910921 gcctttttgt tttttttgaa ggcggggttg gcagaaagag agggataaaa gtggctgtga 910981 ccatcagcat caaagaaaag gcatttgttc aagaaggccg caaaaacacg gtcttagaaa 911041 acatagaatt atcaatcgca ccaggcgaat ttctaacgct tatcggaccg agcgggtgcg 911101 gaaaaagcac cctgttaaag attattgcag ggcttgattc tgaatatgac gggagtgtgg 911161 aaattaacgg ccgcagcgta acagctccgg gtattcagca aggatttatt tttcaggaac 911221 accgcctctt tccttggctg actgttgagc agaatattgc agccgacttg aatttgaagg 911281 acccaaaagt caaacaaaag gtggatgaac tgatcgagat tgtcagattg aaaggatcgg 911341 aaaaagcata tccgcgcgag ctgtcaggcg gcatgtcaca aagagtagcc atcgcccggg 911401 ccctgctgcg ggagcctgag gtgctgcttt tagatgaacc gtttggtgca ctcgacgctt 911461 ttacaagaaa acacctgcag gacgtgctgc tggatatatg gaggaagaaa aaaacaacga 911521 tgattctcgt gactcatgat atagatgaat ctgtttattt aggaaatgag cttgcgatcc 911581 ttaaggccaa accggggaaa atccataagc tgatgcccat tcacctggcg tatccgcgaa 911641 accggacgac tccggatttc caagcgatca gacagagagt gctgtcggaa ttcgagaaaa 911701 cagaagattt ggagtacgca gaaggatcag ggatatagaa agggcggaag cggaaatgaa 911761 aaaaggactc attgtattgg ttgccgttat ttttctgctc gcaggctgtg gagcaaatgg 911821 agccagcggt gaccacaaac aattgaagga aattcgtatt ggtattcagc aaagcttaag 911881 cccccttttg attgcaaaag aaaaaggctg gttcgaagat gcatttgaaa aagaaggcat 911941 caaagtgaaa tgggtggagt ttcaaagcgg tccgccccaa tttgaaggcc ttgcggcaga 912001 caaacttgat ttttctcaag tcggtaattc gcctgtgatc gctggacagg cggcaggcat 912061 tgactttaaa gaaatcggtt tgtctcagga cggcttgaaa gcaaacggca tccttgtcaa 912121 tcaaaacagc ggcattcaag acgttaaggg cttaaagggg aagaaaattg cagtcgccaa 912181 aggcagcagc gggtttgatt ttttgtataa agcgcttgat caagtggggt tgtcagctaa 912241 cgatgtgaca attattcagc ttcagcctga tgaagcagct tccgcatttg aaaacggatc 912301 tgttgatgcc tggtccattt gggagccgta cttgtcctta gaaacaatga aacacggagc 912361 aaaaatcctt gtgaacggag aaagcacaga tttatattca ccgggtttta ctttagtaag 912421 aacaaagttt tcagaagagc atccagacga agtggtccgt tttctgaagg tgtttaataa 912481 agccgttgta tggcaaaagg aacatctgga tgaagcagcg gacttatatt ctgacattaa 912541 agatctcgat aaaaaggtcg tcgaaaatgt gctgaaaaat actgagccac ttaatgagat 912601 catcagtgac gacattgtga aagcacagca ggaaacagca gattttcaat ttcgaacaaa 912661 ggcgatagat aagaagattg atgtgaagga tgttgtcgat aacactttta tcaaaaaagc 912721 attagaggag cattcctcag gaggtgatca atgatgaaag cagaggctgc gggctcgctg 912781 cccaaaacga atgcggaagc ggtgcgaaaa aagcccggaa ggaagagata cggctggatg 912841 aaggggcttt tactgcccgc tgtcatcatt gccatctggc aggtcatcgg cgggctgggg 912901 gttgtgtccg ctacagtgct gcctacacct gttacgattg ttctgacctt taaggagctt 912961 attttgtccg gcgaactgtt cggccatctg caaatcagca tttatcgggc ggcacttggt 913021 tttttgcttg gcgcggggct tggattgatg atcgggattt tggccggatt ttccaaacgg 913081 acggagctgt atcttgatcc gtcgttgcaa atgcttagaa ccgtacctca tctggccgtc 913141 acgccgctgt ttattttatg gttcggattt gacgaagtat ctaaaatttt gctgattgcg 913201 ctcggtgcct tctttcctgt ctatatcaat acgtttaacg gcatccgcgg ggttgacgcg 913261 aagctgtttg aagtcgcccg ggtgcttgaa tttaaatggc atcagcagat atccaaagtg 913321 atattgccgg cagccctgcc caatatattg ctaggcattc gcttatcgct cggcattgca 913381 tggctcgggc tcgttgtggc agagctgatg ggctcaagct cgggagtcgg ctatatgatc 913441 atggatgcga gacagttttc acaaacgaat aaagtctttg cagggattat catttttgca 913501 gtggttggaa agctgacgga ttccttcgtc aggctgcttg aacgaaagct gttaaagtgg 913561 agaaacagct acgaaggata aaagatataa aggggagatg aatatggaaa ttctttggtt 913621 tataccgact catggagacg cgagatattt aggatctgaa agtgatggac ggactgcgga 913681 tcatctttac tttaaacaag tcgcgcaggc ggcagacagg ctgggatata caggagttct 913741 tctgccaacg ggaagatcgt gcgaggaccc gtggcttaca gcgtcggcac tggcaggaga 913801 aacaaaggac ttaaagtttt tagtcgcggt aagacctggt ttaatgcagc cttctctggc 913861 agccagaatg acatccaccc tagaccgcat ttcagacggc cggctgctga tcaacgttgt 913921 ggcagggggc gatccgtatg agctggcagg cgatggcctg tttatcagcc atgatgagcg 913981 ctacgaggca acagacgaat ttttaaccgt ttggcggaga cttttgcagg gagaaacggt 914041 ttcctatgaa ggaaagcata taaaagtgga aaacagcaat ctgcttttcc cgccgcagca 914101 agagccgcat ccgcccatct atttcggtgg ttcgtcacag gctggaattg aagctgccgc 914161 aaagcataca gacgtgtact tgacatgggg tgagccgcct gaacaagtaa aagaaaagat 914221 agaaagagtc aaaaagcaag cggcaaaaga agggagatcc gttcgatttg gcattaggct 914281 gcatgtcatt gcccgtgaaa ctgaacaaga ggcatgggaa gcggcagagc gcttgatcag 914341 ccacttggat gatgacacca ttgccaaagc gcaggcagct ttgagccgtt acgactcttc 914401 aggccagcag cggatggccg tccttcatca aggcgatcgg acgaagcttg aaatcagccc 914461 gaatctgtgg gcggggatcg gcctggtcag aggaggggca ggaacagctc ttgtcggtga 914521 tccgcagacg attgccgacc ggatagcgga gtaccaggca ctcggcatag aatcgtttat 914581 attctccggc tatccgcatt tagaagaagc gtattatttt gcagagcttg tatttccgct 914641 tttgccgttt gaaaatgatc ggacgagaaa gcttcagaac aaaaggggag aagcggtagg 914701 aaacacttat tttgtcaaag agaaaaatgc atgagtttaa ctaaaataca gccccccgaa 914761 catggtatga tattcaaaaa aagggggctt tttttctgaa aacattgaga agcgcggcag 914821 tcatttgcct catagctatg ctgtcagcat gcggacattc aaaacagatg gaaatcaaag 914881 cggcggacat atcagatctt gaaaaaaaca gaatggatgt cgcagcttca caggcattca 914941 ctgccgaagc cgtcaatatc ggtgaaggta tttcttcagc tgacatgtac atcgaacatt 915001 atcaaaaggg aaagcttgtt gagaggtttg gaccggttcg tgcagattat tcagaggaaa 915061 aaactgatac catacaattt gtttattttg agaatgaaga gggggaagga aagaataaac 915121 ataccaccat tcattttggc attgtggata aacagggaac tatagcggct gattcatcgg 915181 tgaaacgcga cgatagcaca acacaggaaa tgactcagaa tatttcatcg ccggaaccga 915241 ttactttcga gaagcctgct ttgatcggca gcagtattag agggactgac gagacaatgc 915301 acacctctga acataaaaaa gagctcatta agcatcaaga tgcgttactg tattatgtgg 915361 aattgcatca ttagaatggg cggcttcagg ccgtctgttt tacaaagcgg tatgcttgct 915421 tttttgaatg gtgaatgata cattttaaat cgtaacaatt tcgatttaaa gggaggctat 915481 gtgacttggc taaaaaatca aaagtggcaa aagagttaaa acgccaacag cttgttgagc 915541 aatacgctgg tattagacgc gagttgaagg aaaaaggaga ttacgaggca ctcagcaagc 915601 tgccaagaga ttcagcaccg ggaaggcttc acaaccgctg catggtaacg gggcgcccga 915661 gagcatatat gaggaagttt aaaatgtcca gaatcgcttt cagggagctg gcccataaag 915721 gccagattcc cggtgtgaaa aaagcaagct ggtaagaaaa aactccggcc gattacagcg 915781 cgccggagtt tttttcgttt ttcttgaaag agatgacgta ggaaaggtgc tggatgatca 915841 tgatgataaa cacaataata atagggaaaa acggaatgcg cgattgaaat agcggataaa 915901 aaatgagaag aaccgctgcg gcaggcagcg agaagtagac agcgatatat gacgcgcgac 915961 atgcttttgc cgtcatcatc tgctctcttt catcctgctc ttcaaactca tcaggcagaa 916021 gtagctgctt tctggcaggg cggctttttt tctgtaagta caaataaacc gcagacgccg 916081 caacaaacag aataaaggga gtgaggttta aatcaaatac catcccgccg ctctttgtgc 916141 cgaaaaaaga tgctatgcct tctgaggctt caaagtatga aatcagcgcc cagcatgcaa 916201 ggccaaataa aacaaggtga aaagctgctt ttgttttcat gctcatctta gttttcctcc 916261 tctaaccaaa agacatcctc cattttcatg gagaaggctt tgcagatttt cagtgctaac 916321 agcagtgagg gaacataatc gcctttttca atcgctgcca cagtctgtct tgtgacgccg 916381 accgtttctc cgagtttttc ctgagaatag ccgaagcgtg ccctcagctc ttttacttta 916441 tttttcatca tgacgtctgt ccccttcaca atctcgattg attatattgt atagtatact 916501 taacattatg taaatggaac ttaacaactt tacaaaaaga taactttttt tcgacaaaat 916561 ttttatattc ccttgacgaa aaataaataa acatgtaata taaaaaaagt cagagcggta 916621 ctgttgctga caatcacaaa tgcgggtgta gtttagtggt aaaacctcag ccttccaagc 916681 tgatgtcgtg agttcgattc tcatcacccg ctccatacat acgttattaa cgcagtgttt 916741 cgtttctcag ataaacgaag tattgcgttt ttttatgtga aaaagaacac ggtattcgtg 916801 ttcttttacg taagccaatg tactgtatgg gtgccgccgt gaatttgttc aaacattttc 916861 gttaatgatg ataagaggtt aacagcgctg cttttctcaa tcgatggcgg gaaaaaaatg 916921 atttgcagca tattcttagt ctcgtttgaa acgggatagt ggttgacgct gtttttgaaa 916981 tcgccaaaaa tgccgttttc atcagagaaa agcagtatgt tttctttttc tcccaatgag 917041 atccggaccg gctcatgaag ctttccggca tcataaatca taataggcag agaatatttt 917101 aatgcgaaaa aatcgattgt gtcatgggcc gagtctttac tttccatgaa ttgttccttg 917161 gatatcggga ccagcatgtc ctccattggg gttgtttctc cctcaaatga agggttaagc 917221 tgtttaaaga gtttctgcca ttccttgacg aaggattcat cggatatacc gccgtccgca 917281 tagtcgaaaa acaaggattc ttgaaacagg cggagtctgc ctttcagcat ttgcggtgag 917341 gagccgactt cgatattctc ataaatgaca gcagctgcat gtaagccggc cgcacgttca 917401 gtaataacag aatcaagttt gatattcact agcattcact ccagttacgt gatatcaacc 917461 tattataaac gctgtgtcgt tttatcacaa agaaaggagg ctgtgcaaaa catgaacgtt 917521 tatcagctca aagaagaatt aattgaatac gcgaaaagca ttggcgtaga caagattggt 917581 tttacgaccg ctgatacttt tgacagttta aaagaccgtt tgattcttca agaatcactc 917641 ggctatctct ccggctttga agagccagat atcgaaaaaa gggtgacgcc gaagcttctt 917701 ttgccgaaag cgaaatcaat agtggcaatt gctctcgcat atccttccag aatgaaggat 917761 gcgccgagaa gcacgagaac tgagcgcagg ggcatttttt gcagagcttc ctggggaaaa 917821 gactatcatg atgtgctgag ggaaaagctt gatctgctgg aggattttct aaaaagcaag 917881 catgaggata tcagaacgaa gtcaatggtt gatacaggtg aattgtctga tcgcgccgtt 917941 gcggaacgtg ccggaatcgg attcagtgcg aaaaactgta tgatcacaac acccgagtat 918001 ggctcttatg tgtatttggc ggaaatgatc acaaatatcc cttttgagcc tgatgtgccg 918061 attgaagata tgtgcgggtc ctgcacgaaa tgcttggacg cctgcccaac gggagcactg 918121 gttaatcccg ggcagcttaa tgcgcagcgc tgcatctctt ttctgaccca gacaaaagga 918181 tttttgcctg atgaattccg gacaaaaatc ggaaaccgcc tgtacgggtg cgatacgtgc 918241 caaacggtat gccctctcaa taaagggaag gattttcatc ttcatccgga aatggagcct 918301 gatcctgaga ttgccaaacc gttattgaag ccgcttttgg ccatcagcaa tcgggaattt 918361 aaggagaaat tcgggcatgt ctcaggttct tggcgcggaa aaaaaccgat tcagcgaaac 918421 gccattctcg cgcttgccca ttttaaggat gcttccgcac tgcctgaatt gacggaactg 918481 atgcacaagg atccgcgtcc tgtcatcagg gggacagccg catgggcaat cggaaaaatc 918541 ggagaccccg cctacgcgga agagcttgaa aaagcgctgg aaaaagagaa ggatgaagag 918601 gcaaagctgg aaattgaaaa aggaattgag ttgctaaaag cttcaggcat gactaaacaa 918661 ggcctgtcct gacatacgta tagagcagaa ggaaaaaaca cttgagatca tccaagtgtt 918721 ttttctctat aaaaaagtat ggcgggtggg gtgagcttga agtacatttt agaacaatta 918781 gcggaggagc ggctgggctt tctggttaac gggcatgcta tgagacagga gtctcaagtc 918841 ggagacctta aagtcatgga gcgtaagaaa aagcttctgg aaaaacgtaa agttgacatc 918901 ataaaagcga aagcaaaggc cgtgattaat catgtgcggg ttgaggatga cggaacgacc 918961 tgcctttcgt ataccatcca ttacgaatac gtgtgtaagg aacaagatga cagcttgtat 919021 atagaagagc acatagagga gcgaatggct ttcctgtatg atcacatttt gattagtgat 919081 caggaaattg cgaaaaagcc ggctggattt catgaaggga ccagtattat tgactattct 919141 gaagctgaag aggaaagaga agcgtttggc agggcttttc aatacgatcg tctcggcgct 919201 gtccaatatg ccgagaaatt ttggaacaag cgcaatcctg cttataaaaa tttcagcgat 919261 aactgtacaa attttatttc tcagtgtctt catgcaggag gcgcgccgat gcgcggtcat 919321 ccgaacaggg gatcaggctg gtggatgaaa caaagctcat ggagctacag ctggacggtg 919381 gctcactcta tgaaaatgta tttgtcgaat tcaaaggccg gactgcgtgc ggtgcgggtg 919441 aaatcagcgg aagaactgat gccgggcgat gtgatttgct atgacttcga aggagacggc 919501 cggtttaatc atacaacgat tgtcgtggca aaggacaaag gcaatatgcc gcttgtcaac 919561 gcccagactt atgacagcag gatgaggtat tggtcatatg aggattctac ggcatacacg 919621 ccgtcaatac gatatgcctt ttttcatatc gttgatgata cgacaaaaga gtaattaatg 919681 ttataatgat gggcggataa gaaaaacaga ggtgaacatt gtggcattac atgtcgtttt 919741 atatcaacca gaaattcccg ctaacacagg gaatattgca cgtacttgtg cagcaaccaa 919801 tacaacgcta cacctgattc gtccgctcgg cttttcaacg gatgataaaa tgctgaagcg 919861 tgccggactc gattattggg agtttgttaa cgttgtgtat catgattcgt tagaagaatt 919921 gtttgaggca tataaaaaag gcaagttttt ctttattaca aaatttggcc agcagcctca 919981 tacatcattt gattacactg atcttgacga ggattatttc ttcgtgttcg gaagagaaac 920041 aagcggtttg ccaaaggatt taattcaaaa taatatggac cgctgcctgc gtcttccgat 920101 gacagagcat gtcagatcgt taaatctgtc caatactgcc gcgattcttg tttatgaagc 920161 gctgcgccag caaaattacc gtgatttaaa atagtgaaaa acccgctcat cgatgatggg 920221 cgggtttttt tgcggatgtt gaaatgcttt gtttcgtttt tgggcttaac aacgtaacag 920281 tgttatgtta caatgtaccc atcaaaggag ctggacttat ggaagaacaa ttaatctcta 920341 aaaaagaatt acttgaaaga acatcgattt catacggtca gctgtatcga tggaagcgga 920401 aaaacttaat acctgaggaa tggtttattc gtaaatccac atttacaggg caagagacgt 920461 tttttccgag agaggagatt ttaaaacgta tatcaatgat tcaaaagatg aaagaaaatt 920521 tgtctttgga tgaaatgagg gaaatgctgt cgccgaaaat gaaggatgtc agcatgaccg 920581 ctgatgaatt gcttcataaa ggtttggttt caaggcctgc tcttgaagcc tattcagaag 920641 acggaggaag tccggttttt tcatccagcg atttgctttc gctgtttgtg cttgagggcc 920701 tgctgcagtc tggaaatgtc agccttgcag aagcaaaaat ggctgcagag gtattaaaga 920761 agcatgatac tgaagagatt gaaaaacaga cggagctgat tgtgctccgc aagctcggtg 920821 tcacaacttg ttttatagcg gctgcggcgg acagcatttt gtttgaatca tccgtaaagg 920881 ttgtggaacg ggtagattta ttaaaagctt cagaggaatt aaaaacaaca tttatgcagg 920941 agggccatca atggatgtag tggaaaagct ggtgataaat ggatcaggaa gttctaaggg 921001 aggaacattt caatcagttg agattaatgg cagcgggaca gtggccgggg acgtggagtg 921061 tgacactttt tcttttaatg gaaacggaaa agcggacggc agcgtcaaag cgaaagcggt 921121 aactatcagc ggttcaggaa agatacatgg agacgttgaa gcagaatcta tccggatgaa 921181 tggcactggt tttattcaag gagaggtatc tgcaaaacaa ttgaaaatcg ctggatcatc 921241 aacatttggc ggcactgtca aggctgatgg aattgacatt agcggaaaag ctgtcatgga 921301 agcagattgt gaaacagaaa cctttcaatc agaagggaaa tgcaaaatca gcgggctttt 921361 aaatgcagac caggtgatca ttaagctttc tgcaggggaa agctatgcgc gggagatcgg 921421 ctgccgccat cttcaagtga cctgcagaaa aggaatgctg acattgctca gattgatgcc 921481 gcagcctgtt ctaacagcag agctgatcga aggtgacgtg attgaattga caaatacaaa 921541 ggcgaaaacc gtgcgcggta ataaagtgat catcggcccg gattgccaga ttgaaaccgt 921601 cgaatacagc ggggactata cctgtgatcc aagcgcgtcg gttgaaacat ccacaaagtt 921661 gtaaggagga tcgtaatgga gacaacaaaa ctgggaaatt taaaattata tggcgctggg 921721 catgccgcag gaggcgcgta tcacaatgtc agcatcaaag gagaaggtat agttggagaa 921781 gggctgtctg ctgtaggctg ccgcatatac ggaacgggcc tttttctcgg aaaagcagag 921841 actgagcggc tgcgtgtgct cggagaaagt gaatgtaaag gcgatctgac agccggcaaa 921901 atcaatatat atgggacaat gaaagtcagc ggctcacttc aatttgatcg attcaatctg 921961 aaaggccaga ctgaaattgg cgggaatatg actggagaat cctgcgatgt gaaagggaag 922021 cttagcgtaa taggtgattg tgaaacagaa atgttccatg tcacaggctg tgttgatgta 922081 tcggggttat taaattcggg tgagatcaag ctgggattga gccatgatat aagccatgtg 922141 caggaaatcg gcggaacaac aattacagtg aaaagacgcg cgagtttttt tagccggaag 922201 aaagggaagc tgatcgccga tgtcatagaa ggagatcggg tttatttgga gaataccgaa 922261 gcggcagttg tcaggggaaa agaagtgatc atcgggccgg gatgcagcat cggaacgatt 922321 gagtacgaat acaaatgtga atgcgatccg cattcacaga ttaaagaaaa aacaaaactg 922381 taaaacattg ttctgttata caaaaagggt gctctttcag gagcaccctt ttttattctt 922441 ttccaggctt gctttcgtat cctgcggtaa aaattgatac taaaaaagtg acaatgacac 922501 ccatcatgat gattgttttc accgtctctc cccctcttca atttttccgt gctgtccgag 922561 tctggatgat tctgtatttt tctttattat gaacggtcgc agtctgcctt gtcaacgatg 922621 tatgagtatc tttattttta agaaaccaaa gcatgtatca cgagatggcg gcatagattg 922681 tatcaaagta ccttatttgc atagtgtatc aaacatgata gaggaggtcc ttatggatat 922741 attaaagaaa attgaaaagt acagagagga agagcagcgg ctgaaatggg aaggaacttt 922801 cgccgattat ttggagatta ttaaagaaaa tccgatggtc gcgcaatctg ctcattctcg 922861 agtttttaat atgataaaag acagcgggat agaggagatt gacggacgca agaagtacag 922921 tttttttgac cgcgagctgt tcgggcttga agaatctctg gagcgtcttg tggaagagta 922981 ttttcatccg gctgccaaac gtctagatgt cagaaagcgg attctattgc tgatggggcc 923041 tgtgagcggc ggtaaatcca cgctggtcac aatgcttaaa aaaggtctcg aagcgtacac 923101 gctgacagat aatggcgctg tatatgcgat taaaggctgc ccgatgcacg aggaccctct 923161 acatttaatc ccccatcatt tacgcgatga cttttacaga gaatacggca ttagaataga 923221 aggaagtctt tctcctttaa atgtcatgag gctggaggaa gagtacggag gaagaattga 923281 ggatgtgaag gtggagcgca tcttcttttc agaagataag cgtacgggaa ttggaacatt 923341 cagtccctct gatccgaaat ctcaggatat tgccgatttg acggggagta ttgatttctc 923401 aacaatcgcc gagtacggtt cagaatcaga tccgcgcgct tatcgatttg acggagagct 923461 gaataaagcg aaccgcggga tgatggagtt tcaggagatg ctgaaatgtg atgagaaatt 923521 tctctggcat ttgctttcct tgacacagga agggaatttt aaagctgggc ggtttgcgtt 923581 aatttctgct gatgagctga tcgtggctca cacgaatgaa acggagtatc gctcatttat 923641 ttctaataag aagaatgaag ccctgcactc aagaatcatc gtgatgccgg ttccttataa 923701 tttaaaagtg tctgaggaag agagaattta tgaaaaaatg attgcagaaa gcgatgtggc 923761 ggatgttcat attgccccgc atacgttgaa ggtcgccgcg atgttctcaa tccttacccg 923821 gttaaaagag ccgaagcggt cggatattga tctggtcaag aaaatgagac tgtatgatgg 923881 ggaaagtgtg gaaggatata actctgtcga cgttgaggat atgaaaaaag aatataatga 923941 tgaaggcatg agcggaattg atccgcggta cgtgatcaac cggatttctt caacgattat 924001 cagaaaaaat atggaatcga ttaattctct cgatgtcctt cgctccttaa aagaaggtct 924061 tgatcagcac ccatcaattt caagcgagga cagggagcgg tatttgaatt ttatctctgc 924121 cgcccgcaag gaatatgacg atattgcgaa aaaggaagtt caaaaagcgt ttgtttattc 924181 atatgaagaa tcagcaaaaa cacttatgga caattacctc gataacgtag aggcctattg 924241 caataaaaac aagcttcgtg atcctttgac aggagaggaa atgaaccctg acgaaaagct 924301 gatgagatcc atcgaagagc agatcggcat ttcggaaaac gccaaaaaag cgttccgcga 924361 agaaatttta atccgcatct cggcctatgc gagaaaaggc aagcggtttg attacaattc 924421 ccatgaaaga ctgcgtgaag ctattcagaa aaagctgttt gctgatctga aggatgtcgt 924481 taaaattacg acctcaacaa aaacgccgga tgagcagcag ctgaaaaagg taaatgaagt 924541 cgtggcccgt ttaattgatg agcacggcta caactcgacg agcgccaatg agctgctgaa 924601 atatgtcggc agcctgctga accgataagc aacgtgaccc gtccgaatag ggcgggttat 924661 tttgtcccat tttctaaata gtttgtcaat taaacgtgca tatgtgcata tgatgaatat 924721 aaatcttttc aaaagacttg tttcataatc tggcacaagc cggaatacgt atgtatcacg 924781 accacaaatg gttaaggagg ggaattcatg tcccaaaatg acagcggcca ttttttgatt 924841 tctgaggaaa actggtccct ccatcgcaaa ggcttcgatg accagcagcg ccaccagaaa 924901 aaagtgcagg aagcgatcaa aaacaatctt ccggacctcg taactgagga aagcattatt 924961 atgtctaatg gaaaagatgt agtgaagatc ccaatccgtt cacttgatga gtataaaatc 925021 cgttataact atgataaaaa taaacatgta gggcaaggag acggcgagag ccaggttgga 925081 gatgttgtgg cccgggatgg atcagacaaa aaacaagggc ctggaaaagg gcagggtgcc 925141 ggtgatcagg caggcgagga ttattatgaa gcggaagttt cattaatgga tttagaagaa 925201 gcgcttttta aagaattaga gcttccgaat ctccagcaaa aagagcggga caatatcatt 925261 catacagata tcgagtttaa tgatatccgt aaaacagggt taaccggtaa tattgataag 925321 aaaagaacga tgatgtcagc ctttaaacga aacgcaatgt caggaaaacc gtcgttctac 925381 ccaatttatc cggaggacct gaaatataag acgtggaatg acatcacaaa gcccgaatca 925441 aaagccgtcg ttttagccat gatggataca agcggcagta tgggggtttg ggaaaaatac 925501 atggccagaa gcttcttttt ctggatgacc cgttttttgc ggacaaaata cgagactgtg 925561 gaaattgaat ttattgccca tcatacagaa gcaagagtgg tctcggagga ggattttttc 925621 tcaaagggag aaagcggcgg aacaatttgt tcttccgtat atcggaagtc gcttgagctt 925681 attgatgaaa agtacaatcc cgcccgctat aacatttacc cgtttcattt ttctgacggt 925741 gacaacctga catctgataa cgcgcgctgt gtgaagctgg tcaatgatat tatgaagaag 925801 gccaatctgt tttgctacgg cgaggtcaat cagtacaaca ggcattcaac gttaatgtct 925861 gcatataaaa atgtaaaaga tgagaaattt aagtactata ttttaaaaca gaaatctgat 925921 gtttttcagg ctctaaagaa ctttttcaga aatgaagagt ctggtgtaag ccatcaattt 925981 tcgtaatgaa aagcccattt cagggctttt ttttatttaa taaaagcaag aaaacgcttg 926041 cgaaaaaaat acgggagaaa aagaaatttt tcctttgaca aatcttcttt catttattaa 926101 tattttatct tgtgaactat tattgaggaa tgaggtgaaa aggagttgac tgaatcagaa 926161 cgtgctttgc tcacttttga acagctcttc gatacgtctc gggcgatata taaaaaacag 926221 aagaagatat tggagattgt gcttgagcct tttgatatta cagtccttca atatttgctg 926281 atgtttaaaa ttcatcaaag cggaagcacc ccgctaagca agctggcaat gtcgcttgat 926341 cttaagcctg cttctgtgac gcggatgaca gatattctgt ataagcgcca attgatgaat 926401 cgatatgaca gtccggatga ccgccgtatc gtcatgattc agttaaccga agagggggaa 926461 gaactgatag aaaaagccgc tgtgcaatat gcaaaaatgg gtgctggctt gtaccaaaag 926521 cttgatacct cccagctgca gtatttgcgc aaactagccg gaagtttaac gaagcttgct 926581 gaaggctgtt cagaaaaaag cggtaattaa aaacttctca catattttca ccagctttcc 926641 gcaaaatgat agaggatgaa acgaaaggag aaaacaaaat gaacagagga cgtttaattc 926701 tgaccaacat tatcggtttg attgttgttc ttgcaattat agctggaggt gcttactact 926761 attatcaaag cacaaactac gtaaaaacag atgaagcaaa agtagcgggc gatatggctg 926821 ctattactgc tccagcagca ggtaaagtat ctgactggga tctggacgaa ggaaaaacag 926881 tgaaaaaagg cgacacagtt gcaaaaatca aaggtgaaca aactgttgac gtaaaatcca 926941 ttatggatgg cacaattgtg aaaaacgaag tgaaaaacgg acaaaccgta caagctggta 927001 caacaattgc acaaacgatt gacatggaca acctatacat cacagcaaat attaaagaaa 927061 cagatattgc ggatattgaa gtaggaaata gtgtagacgt agtagttgac ggagaccctg 927121 atactacatt tgacggtact gtagaagaaa ttggttatgc gactaactca acttttgata 927181 tgcttccttc tacaaattca agcggaaact acacaaaagt aacacaaaaa gttcctgtga 927241 aaatttcaat caaaaaccca tctgataagg tgcttcctgg aatgaatgca tctgttaaaa 927301 tttctgagta aaacagatca gtcatcaaac catgaaagga ggttgtctta gatggctaca 927361 ggcaaagaaa aaaatgcaaa aaaccctatg tcattgctga ttgtgctaat ggcgggttta 927421 tttttggcaa ttctaaacca aacactgctt aatgttgcaa tgccgcactt aatgactgaa 927481 tttggcgtaa gtgcaacgac gattcagtgg ctgacaacag gttacatgct tgttaacggt 927541 gtattgattc cgttatctgc tttcctgatt acacgatttg gccagcggag tctctttctc 927601 gtcgcgatgt tttgttttac gctcggtacg ttagtctgcg gtatcgcacc taacttctct 927661 acaatgctga tcggccgttt gattcaggcc gtgggcggag gtatcttgca gccgctcgtt 927721 atgacaacca ttctgttaat tttcccgcct gaaagcaggg ggaaaggaat ggggattttc 927781 gggctagcga tgatgtttgc tccagcggtc ggcccgactc tttccgggtg gattattgag 927841 cattatacat ggcgcattat gttttacgga cttgtgccga tcggcgcaat tgttatcatt 927901 gtggctttct tcatctttaa aaatatggtg gagccgcaaa aaatcaaact cgatactctt 927961 ggcgcaatcc tctcgattgt cggattcgcc tccttattat acggagtcag tgaagccgga 928021 tctgacggct ggaccgaccc gattgtattg tctacagtta ttatcggagc cattgcaatt 928081 gttgcttttg ttgttcagca attgcgtcat gatgatccga tgcttgattt cagagtgttt 928141 aaatatgaca ttttctcact ctcgagtgtc attaatatca ttattacagt ggcactttac 928201 actggtatgt tccttttacc gatttatctg caaaacctgg tcggctttac ggcgcttcaa 928261 tccggtctgc ttctgcttcc gggtgcgatc gttatgctga ttatgtcacc gatctcaggt 928321 attttgttcg ataaattcgg accgagaccg cttgcgatta tcgggcttct cgtgacagtg 928381 gtaacaacgt atcaatacac gcaattgaca attgatacac catatacaca catcatgctg 928441 atctattcaa ttcgtgcatt tggtatgtct ctcttaatga tgccagtcat gacagccggg 928501 atgaaccagc ttcctgcccg tctgaacagc cacggaacgg cgatgagtaa cacgcttcgc 928561 caaatcagcg gatcaatcgg aacaagttta attacgacga tttatacaaa ccggacgaca 928621 ttccattatt cacaaattgc agataaaaca agcacggcgg acccgaactt cctccatgcg 928681 ttccaaaatg cagtttcgaa tttaatggtg aatatgaatg tgtcttatga tacggcgaaa 928741 acatatgtgt actcacatat ttataaacac gcatcactcg attccaatgt catggggata 928801 aatgatgcct ttatgtgggc aaccttattc tgtgtagcag gtttgatttt aagtatcttc 928861 ctgcgtgacg tcagaaaaga taaattgcgt aagaagaaaa aagaggagct ttcattactt 928921 cctgctccaa aagaagctaa ggaatcttaa tctgtacagg gaggtttcct gaatgaaaat 928981 ttatgtagtg tatgatagtg aaggcgaaca tactaaagtg cttgcagaag cgattgctga 929041 aggcgcgaga gaaaacgacg cggctgaagt gttcatcgac catgtagatc aggctgatat 929101 ccgcaagctt aaagatatgg atgcgattat ttggggatgc ccagggcatt tcggaacaat 929161 cagctccggt cttaaaactt ggatcgacag acttggctac ttgtgggctg aaggcgagct 929221 gatcaacaaa gtcggtgctg tcttctgcac aacggcaaca acacacggcg gcttggaaat 929281 gacaatgcac aatttaatca cgccgatgtt ccaccaaggc atgattgttg tcggactgcc 929341 tggcaacgtg cctgaaaacg cactttatgg ctcttattac ggagcaggtg tcacttgtcc 929401 ggtagacagt gatgagttaa tgtctgagga aggtattcag cttggacgcg cgttgggaag 929461 acgtgtcagc caagtcacag gaaacctaac agcaggacag taaggagagg ttgaaatggc 929521 cattattata gcaataattg ctgctgtcat tgtcattgcg gcccttatta catttaacgt 929581 ccgcaacgcc tcacctggac ctgagaagca agaagcaacc gatagaatcg cacctccaga 929641 agaggaaaaa aacgaagcgc attaccctgc tgaagcaagg gctgccgagc atacgccatc 929701 cgttgtcaaa aacgattctc caaaagagaa gcgtgacaca atgggtgatg atatttacag 929761 gcaggcgctg caaaagttta agcattctga tgaagttcat gcagaagaag aggtcactga 929821 ggaaagtgac aaaatgcagg accgcagcta tcgtgatgcg ctgctctcta tgaaaaataa 929881 gaaaaagtaa tgaaaaaggc aaatccgttt actcatgcgg gtttgccttt tttgctgttt 929941 ccatcaatta tgtttttatc aaataaatcc atggaatatg ttgtattcca ccttgatcta 930001 gtgtactatg ttactcatac accgaggatt ttttccggga ggtaaagaca tgaattcttt 930061 tttaggttta ttaaagaaag atatcaagct ttcaagaatg tggctgctag tatggatatg 930121 cggaatcatt ttcttattgg gaacaggcca tattatagct tctcgcacga aagaacctct 930181 agtcattttt ggtttttttg ttgcagttgc tttttttctg cttttcttat ctcctgtttt 930241 tgttttttat caccttcgca aggaagggaa atcacagctt tggctgtaca atccaaatgg 930301 cggcttatgg ctgttttctt ctaaattggc agcatctttg ctctatcaat ttgtgattca 930361 gttggcatta acagcctatg gcatatggat gtatcatatg ctctctgtaa aaaatctgct 930421 ggagcatcaa gttgatataa cgagtacagt ggctttgctg aatatgtatg ggcttatttc 930481 ttcgttagat atgtcagtaa cagtcattgt gttttggact gtttttcact ctctcagaaa 930541 ttggcgcgga atgcggtggg ctgcgatggt tctgttggtc gcaatgtggt tattcttcga 930601 tgaatacatc ataagccctt tggttgaatc tcaaaagcat ttctggcctg taacagtcta 930661 ttgcaatttt gatttccact tccacaatgt ttggagattg gaactaaaac ctatccatct 930721 gtctgtgcta gggtttccta ttgctatagt catcacattc ttgctgctca tcatggcttc 930781 aaaactgctt gatcgtaaag tagaggtgta aatatggaca atcaattcca atcctcgaaa 930841 ccgatttatc tgcagatcgc tgatcagatc ttttataggc tggtcaggaa ggagctgctc 930901 ccaggagaca agcttccttc agtaagagaa atggcgattc aaactaaagt aaatcccaat 930961 acaattcaaa gaacttacag tgagatggaa aggctgggta ttgtggagac aagaagaggt 931021 caagggacgt ttattgcgga aaaagcagaa atcgtagacg agctgaaaga caagctgaca 931081 cgagaggtgc tggaaggctt tgtcaagcaa atgaaagagc tggggctaac gaaagaagaa 931141 atgttagaag ggattaaaac attcacagag ggaggctaaa atggaaatca agctagaaca 931201 tgtatcaaaa aaatacggcc gccatacggc cgtcaatgat gtgtcaatca ccctatcatc 931261 cggacggatt tatggcctga ttggaccgaa cggcagcggc aagtcaacga ccctgaaaat 931321 gatggctggc cttctgtttc cgacttcagg atttgtaaaa gttgatgaag agcaggttac 931381 gagagaaatg gtgcgtcaaa cggcttatct tactgagctt gatatgtttt atccgcattt 931441 cactgttaaa gatatggtga atttttatca gtcgcagttt cctgattttc atacagaaca 931501 ggtttataag ctattgaatg agatgcagct gaatccggaa aaaaagatca aaaagctatc 931561 aaaaggaaat cggggcaggc tgaaaatcgt tcttgcttta gcgagacggg cagacgtcat 931621 cttgcttgat gaaccttttt ccgggcttga tccgatggtc agggattcca tcgtaaacag 931681 ccttgtgtcg tacattgatt ttgagcagca gattgtcgtg atcgcgacac atgaaattga 931741 tgaaattgag actttgttag atgaagtaat catcctcgcc aatggagaaa aagttgcgca 931801 gcgtgaagta gaagatattc gtgaacagga aggcatgtct gttttgcaat ggtttaaatc 931861 aaaaatggaa gtttgctaga aagaggagga atatgatgaa aacagtgttg gaattgaaaa 931921 acgtgactaa aaacatcaga ggccgaacga tcattgatga tctcagtttt acgattcgtg 931981 aaggcgaggt attcggtttt ttaggaccaa acggagcggg gaaaacgaca accatccgga 932041 tgatggtggg gttaatgaag ctgtcgaaag gtgatgtcct catttgcggc caatcaatta 932101 cgaaagaata tgccaaggcg attaagcata tcggagcgat cgttgagaat cccgagctgt 932161 ataaattttt gagcggatat aaaaatctcc agcaattcgc aaggatggtc aagggtgtca 932221 cgaaggaaaa aattgatgaa gttgttgaac tggtcggttt aacagacaga atccacgaca 932281 aggtgaaaac atattctctg gggatgagac agcgtcttgg cttggcacaa tgccttctgc 932341 acgatccgaa agtgctgatt ttggatgaac cgacaaacgg ccttgatccg gcggggatca 932401 gagaaatcag agatcattta aagaagctga cccgagaaag aggaatggct gtcatcgttt 932461 caagccacct gctgtcagaa atggaactga tgtgtgatcg aattgcgatt ctgcaaaaag 932521 gaaagctgat cgatattcaa aatgtaaaag atgaaaacat tgatgagaat gatacatatt 932581 tcttccaggt tgagcagccg agtgaagccg ctactgtttt aaatcagtac gatttgctga 932641 gtaagacaaa tggtgtagaa atcaaactgg ctaaagagga agtccctgcg gttattgaat 932701 tgctggtgat gcagcaaatc cgtatttatg aggtcaaggt cataacaaaa tcattagagg 932761 accgtttctt agaaatgaca ggtgaaacaa aagaggaggt tcagcatgct taatttgatt 932821 tataatgagt ggctcaaaat tttcagccgt gccggaacat gggtgatgat cggaattctg 932881 gggctgacaa tggttggatt tgcatttttg gcgaatcatt tttctgccgg tgaatcaaat 932941 tcccattgga aacaagagct tcaagcacaa aacgccgaat taaagaaaga aatcaaagaa 933001 gatccttcac tgaaagatgg gtataaagaa acaatcacac tcaatgacta tcgcatcgag 933061 cataatatcc ctagtgacac gggctatacg gtatggtctt atgtaacgga ttcagcaaac 933121 tttaccatcc ttaccggtct gtttactatt atcatcgcgg ccggaattgt cgcgaacgaa 933181 tttaattggg gaacgattaa gctattaatg attcggccgc tcagtcgttt tcaaattttg 933241 atgtccaaat atattacagt tctcctgttt gggctcctgt tgctgttgat tttatttatc 933301 ggttctactt tattagggtt gatcttcttc ggaacgggtg gtgaaaccgc cgcgaatatt 933361 catttaatct ataaggatgg ccatgtcatt gagcaaaaca tgatggggca tttggctaca 933421 acgtatcttt ctgaatccgt ctcggcttta atggtggcga cgatggcgtt tatgctgtct 933481 gcggtattca gaaacagctc tcttgcggtt ggtttttcca tcttcttgtt ggttgccggt 933541 acgactgcaa ctgcatttat tgcagcgaaa tttgactggg caaagtatat attgtttgct 933601 aatgtcgact tgactcagta tgtggatggc acaccgttaa taaaagggat gactatgacg 933661 ttttctctcg tcatgctggc gatctacttt atcatcttcc tgttgcttgc tttcggaatc 933721 ttcatgaagc gggatattgc aaactaataa aaaaagctgt tttgcttatg caaaacagct 933781 tttttgtcaa aataaaaact gcaggtttgc acctgcagtt tttcatatca atttatgctt 933841 acgcttcttt agtaacgtta gcagcttgtg gtccgcggtt tccttcaacg atttcaaaag 933901 aaacagcttg gccttcttct aaagttttga agccttcgcc ttgaatagca gagaaatgaa 933961 cgaatacatc gtcttgacct tctacttcga tgaatccgaa acctttttca gagttgaacc 934021 attttacttt accttctaac atgaaatttc ctcctaaagc gatcataacg cttaaattca 934081 ctattcttgc tcttaacaaa ctttcaagac gaaaactctt acaaaacttt cttcttaaag 934141 atagttcgaa caaaaataat tacctttact ctaccagtaa tcttcagaaa aaacaactgc 934201 ttattgaaat ttttttcgga aaataccata tttatttttc aatttgatat ttatttacgg 934261 aaattcatct gttttctcga tatgtgatca tacgtttgcc ttagtattcc ttcattttgg 934321 gaagataagt aataggaatt gacaacctta ttggatatga gtaaggtaaa agttaatcaa 934381 tattacaaat gacaacgttt atcaactaag agagcgtatg atttttatgt ctgatattgc 934441 ttgcatgctc taatacatag ataggagtat ggtcacaatg aaaaagtggc ttatatgcag 934501 tttcgtcctt gttcttctcg tttcatttac tgcatgttca ccgtctgcag aacatgaatc 934561 gataaaaatc gggattgctg agtctgacgg ggcaatatgg aactatattg ctcaaaaggc 934621 tgaagaggca gggctggata ttcagctgat ccctttttct gattatgcgg agtctgatat 934681 cgcacttgct aacaaagaaa ttgatgccaa cgcctttcaa accatttcat attttcagtc 934741 gttcactgaa aaatacaaac ttaatttggc accgctcggg acgacataca taacgcccat 934801 gggcatttat tcaaaacgat atgaacgaat ccgagatata tcgcggggag ctgtcgtttc 934861 tgttccggat aaagcgttcg attttggcag ggcgcttacg gtgctccagg aagcgggttt 934921 gctaacgctg aaaaacggat ttaacggaac aggttcagtt gatatgatta aagataatcc 934981 gagacacctg aaattaaaag ctgtccggca acaggatgca gtgagcggtg ccgacgtgtt 935041 tgtcatgaaa ccatcagaag caaaaaaagc gggcttgaac ccgaaaaagc atacgctaaa 935101 gagcggcgga ctcatgtctg aggaagagat gaatttgatt gttgtcagag cggaggatca 935161 agatcgggaa gcgctgcaaa ccattcttga gctttatcaa gctgatgata cagcggcatt 935221 tatagaaaaa gaatatcagg gagatcttgt cccggctttt ctgcctttga aacgtctttc 935281 agattggaag aatgaattcg aacattgaat tcattctttt ttttctgaaa aacacactct 935341 gttccgtccc gtttctttcg ctttgtaaag catttgatcg gcaagaatgg gcaaggatcc 935401 tggctgttcc gtattattgg ggtaatgagc ggcccctagt gatatcgtaa ctgaaagctc 935461 gtcgccgttt gttaatacaa tcggtgcatc acttacagtg ctcctgatcc gttcagcgat 935521 ccgggctgct ttatcaagag aacagttcgg caggagcacg gcaaattctt caccgccgat 935581 ccgagcggca ggatcagtat ttcggatggt ctgcttcaga cgtaacccta gctctttgag 935641 cacctgatct ccttcatgat ggccatattg gtcattgatg gtcttaaaat gatcgatatc 935701 catataaatc agtgcaaatt gaaaatgcgg ggtatcggcc gcctgctgat acagagcttt 935761 tgtggtttct tcaaattttc ttcggttata cacgcctgtt aaaaagtcaa agtgcgcctg 935821 aaacttatat tgtttaaaaa gaagatgtgc atttgtttca tgatcaataa tatataaact 935881 gagcatgccg cccgctattg atatgatcca aaaatacaaa tgaagttcgt atgaatgtaa 935941 atctataaga aaataaaagg aaaaggagat caagctattt gtgattatta aaagatagaa 936001 agcatgtttt agttgaactt tttttcttct agaaacaatg agtgacggaa tggcagcgat 936061 acaaatgata ataaccgagt atagtgcaga tgtgttcatc gtaatcagca agcggcctgc 936121 agtgatcatg gccagggccg ttgccgttga aacccagcct ccataaagag cggcaatcat 936181 aatagggata tttcgaagat caataattga atgctgatag gtaaatccaa aaaccatcag 936241 aataaccccg agcaaaccgc aggccagtcc tttaacagct tgaaaggata tgctgtcttt 936301 tttatgtact agcctttctt taaacaggtg ggtgaagaga taattaaatg tgattaaaat 936361 ggtcaaattt acaaacagtt ctttcagcaa atattatcac ccttatataa ggtactaaag 936421 atggaaggga aagaaaagaa caaaaaaggc attatataag gtttttttac ttgaattgat 936481 aagttaaaat aattcgcact tgacccatcg gaattagtgt aatatagtaa atgagaaaat 936541 ttgaagggag agtttacctg ctttggagac tttactggtt gtattacatg tatttatttt 936601 atttttactt atcttagggc tctttgttat gcagaaaaaa catgtttcct tctctaaacg 936661 tgtatttact gcgctggggc tggggattgt attcggattt gcgcttcagc tgatttacgg 936721 cccgacttca aatatagtca ttcaaacagc cgactggttt aatattgccg ggggcggata 936781 tgtcaaattg cttcagatgg ttgtcatgcc gctcgtcttt atttcgattc tcggcgcctt 936841 tacaaagctg aagctgacaa aaaatcttgg gaaaatcagc ggtttgatta tcgggatttt 936901 agtagcaaca acagcagttg ctgcagctgt cggtatcgcg tccgcgcttt catttgatct 936961 gcaggcgatt caggttgacc aaggaagtac agagctttca cggggacagg agcttcagca 937021 gaaatcagag gatatgacag cgaaaacgct gccgcagcag attgttgaac tgctgcctgg 937081 aaacccgttt ttagatttta cgggagctag accgacttca acgatcgctg tcgttatttt 937141 tgccgctttc cttggagtgg cattcctcgg cgtaaaacac aaacagccgg aacaggcaga 937201 aacatttaaa aaactggttg atgccgttta tgccattgtc atgcgtgttg tcacactcat 937261 tttgagactg acgccttatg gggtgctggc catcatgaca aaaacaattg caacgagtga 937321 tcttgacagc attctaaaac tgggcatgtt cgtgattgca tcatatgccg cgttaatcac 937381 tatgtttatc attcatttgc tgctgctgac gttcagcggc ttgaatccgg tgatttattt 937441 gaaaaaagcg gtgcctgtac ttgtatttgc atttacgtca aggtctagcg caggtgcttt 937501 accgctgaat attaaaacac agagaagcat gggtgtaccg gagggaatcg caaactttgc 937561 cggttcgttc ggtctttcga tcggccaaaa tggatgtgcc ggcatttatc ctgcgatgct 937621 ggcgatgatg attgctccga ctgtcggcca aaatccattt gacccggtgt ttattatcac 937681 tgttatcgca gtcgttgcca tcagctcctt cggggttgcc ggagtcggcg gcggagcgac 937741 attcgcggcg cttcttgttt tatcatcatt aaacatgcct gtcgcgctcg ccggtttgtt 937801 aatctcaatt gaaccgttaa tcgacatggg gcgtactgct ttgaatgtca gcggaagcat 937861 gacatccggt cttattacaa gtaaggtcac aaaagaaatt gatcaagggg catttcatga 937921 tcaatccaga gtgattgaag ctgaagaagc gtaacatatg aaaacgtgta atccaagagg 937981 attacacgtt tttttaacgg ccaggctcta agtcctccag catttccatc atcgtgttgt 938041 cgtccatgac attcattgcg ttttgttcaa aatgaatggg ttcagcataa tgcggctgtc 938101 tttttttcgc ggctgtctca gtttgcctag tttgagactg tgtatgctga tgctgtggtt 938161 gctgctgtcc agcgtgctgg tgctgacggc cattttgccg ctggctttga tgctgcgaac 938221 ggtcctggtt atcaccgctg cttccgctgc ttccgctaaa tgcttgtttg accatgtttc 938281 ctacattaga agcatcaaac gtgttatttt ctgaatttcg tctgttcatt tgtcctgtga 938341 taaacccgct gattctttgg cggatctgag gtgataatgc agtaataagc atagttgatc 938401 ctatgatcaa tgctgcgggg ctgattcctc ttcgctggtt gaacaacatg atccctcctt 938461 tgcagtgtat tcatattttc cccctcgtta gacaaattaa ccgttatatt tcccgggaaa 938521 gcatttcctc cagatttgca tgcataatta aagccagtta gaaaaaccta taagtaaagt 938581 gataaaggag gaattcacat gtttggaaaa aaacaagtcc ttgcgtctgt gcttcttatc 938641 cctttgctta tgactggctg cggtgtagcc gaccaaggtg agggcagacg tgataataat 938701 gatgtaagaa acgtaaatta tcgaaatccg gccaatgacg atatgcggaa tgtaaacaat 938761 cgggataacg ttgacaacaa tgttaatgat aatgtcaata acaatcgtgt aaatgacgat 938821 aataacaacg accgaaaact tgaggttgct gatgaagcag ctgataaagt aacagaccta 938881 aaagaagtaa agcatgccga tatcattgtg gctggaaatc aagcctacgt tgcagtcgtt 938941 ttaaccaatg gaaataaagg tgcagtagaa aacaatctga agaaaaaaat agccaaaaag 939001 gtaagatcta ctgacaaaaa cattgataat gtttacgttt cagctaaccc tgattttgta 939061 gagcgtatgc aaggatatgg aaagcgtatt caaaatggtg acccaatcgc cggattattt 939121 gatgaattta cacaaactgt acagcgtgta ttccctaacg ctgaataaat gaaagaagcc 939181 gcacaatttg tgcggctttt tctttgcgtt aatgacacac tgcgaactca ggctgcatag 939241 agtaaaaata aaaaggtaca agacggaccg gctcagggag ggagacgttt gcgggatggc 939301 ataggaaagc gtgcggcatc cgctctattc ctgtgcggag tccttgtgat gctggctgta 939361 agctcagcca tcgtatcaag cgcgatgtat atcctgtctt ttccaggtca ggcatctgga 939421 ataacaaaag aacaagtgac gaagcacatg aagaaagagt cattcaaaca ggccgatatt 939481 tattacactt ctaaggaaaa gtccttactg ccattgacga aagaaacgct tgaatatgcg 939541 gtcagtatta atcagattat gattggatat tcgaatcaaa agcctattga cattattttt 939601 tttcctaatg aaaaacagat ggaggcttac tccggtttat tggatgtagt tggtttttat 939661 tctgaacggg agcagctgat cggattgttg cctgaagaga aaaagaaact gttagaaggg 939721 gacgaggtag cggtttattt gtaccagaga ttgttgattc atgaatactc gcaccatgcg 939781 tttcaccaga aattgaagga gcttgagacg gatcccgatg agtttccgtt atggtttcat 939841 gaagggttaa gcgagtggat tgcgaactat gaattgctca tagatccgat cacgttttct 939901 gtcgtgccct ttgaccgttt gcagactgat cgagactggc aggaagctag agccgaatat 939961 gacactgatg tctatttgca aagcttttat atgatcgatg agctgacgga caaatacggg 940021 aaagacatta tttcagaaat gattaaggaa acggcaaaaa aaggggactt tgaaaaaggg 940081 tttaaatcag caacaaagga aagtcttgat caatttgaaa aagattttaa gaaaaaattt 940141 gaaaaaaaca gtgcggcatt ggatagtatc tatccaatgc ctttgttatt agtgaagtcc 940201 ttgctgaccc attccgcctt gtgtcggagg catttgtcct tgggcagggg cgaatgaatt 940261 tcgcagctgt tccatatcct gcgcatcaag ctgaggaacc tggtaatagc cgtgtttgtt 940321 ttggtatagg aaaatttcaa atgccatttc aacatactcc tgaatttgcg cagacagtac 940381 gcgtcttacg gccggatttg tcatttccag agaagccatc gtcagcatag aagcttgtgc 940441 tttaatcgcg caaagcattt gtcggctgat gatgctgtca tcaatatcat tcatggattg 940501 aacaggtttt ttaggctgtg acggctgcat gccgtaaaca gtctggttgt cttccttcat 940561 catataagtt gctgtttttt gtgaaggttc gcttcctgtt ttgaagcatt ctgcagttat 940621 attgtattga gatgtgatga attgatgttg acgatcaagg atgtttagta attcttgatc 940681 cttacagaat tgtctcagca tcataaactg atcaagcaca gtaagtgttc cggaaagcac 940741 ctcatgcata tcaaacattt catgtccgcc gtggttttta tgcggtttgc caggaatacc 940801 tttgttcatt tgggattgct gctgctgatt gaactgatcc aaaccgaatt cctccttttt 940861 tttcagatca gctgtatttt gtgtcagtct gccgtgtatt atgcagaagc ctgaaaggaa 940921 ttatatgctg tctgtcgaaa tgataagcag acaaaatcgt tgtcattatg tgtataaggg 940981 aggaaatatg atgaggcgta ttctgcatat tgtgttgatc acggcattaa tgttcttaaa 941041 tgtaatgtac acgttcgaag ctgtaaaggc agctgaaccg caacagccta tatcgattga 941101 gaaggcaata cagcaaaaag aaggacaggc acttgtcgaa ggatatgcag tcggccaggc 941161 tgtttccccg cagcattata aactgacaag ccctttttca aatgattata atgttgcgct 941221 ggcagaccgt aaaaacaaaa catcgcccga acacatcctt cctgtgcaaa tcccctccgc 941281 cttcagaagc caatttgggc tgcaaaccaa tccgcttctt cttgggaaaa agataacggt 941341 tcaaggaaag cttgaaaatt actttaacac gacaggactt aaaaacgttc agtcgatgaa 941401 cgtaaccgat gacacaaaaa ctccgccggc tgaacagcaa gtgaccataa atgaagcacg 941461 gggaaggctg aatgaagaag taacgataaa agggatcatt acagctgatc aaaacgcaat 941521 cggaggcggg aagctgtcga cctttttgca agatgaaacc ggaggcatta acatttattc 941581 gccatcccct gaacaatttc ccgaattaaa agagggtatg gatgtcacgg tgacagggaa 941641 aatcacgtct taccaggggc tgaaagaaat cgttccaaac tcatcaggca tcaaaatcaa 941701 ccagtcaaat caatccctcc ccgcccccaa acacttaaca atcaatgaac ttattaacgg 941761 cagcctaggt gatcagtatg aaggacgcct tgtgaaacta accgcttttg tttcctcaat 941821 tccaagttct cctgccggcg gcggttacaa tgtaacaatg attgatgacg accatcatgc 941881 aatgacgctc cgggttatga atgaaacagg ggtgataaac gagcttgatg agggcaaatg 941941 gtatgaattt accggtgtgt taagcagata ccaaaccttt cagctgcttc cgcgaaaatc 942001 ggctgacctg aagctgcttg aagagcagcc cgcacctccg tctgcagagg gagaatatga 942061 agggattgtt gaccgggtag ttgacggcga taccattcat cttaaatctc cggtgcttgg 942121 aacgacaaaa atccggtttg taaatgtaga tgcacccgaa acatatcaca caccaaaaaa 942181 tgacgcagat gaaaatcaat taagatttgg caaaaaagca tctgactatc taaaaacggt 942241 tctgtccccg ggtgataaaa ttactgtcaa ggtcgggagt gaagccaagg acagctatgg 942301 cagattgctc ggacaagtca taaccgaatc aggttcaaac gtgaacttag agcttgtaaa 942361 aaacggctat gctccgacgt attttatttg gccggttgac aatgaagagg attatcagca 942421 atttcaggcc gcagtagccg ctgcaaaaaa agatcaaaaa ggaatttgga atgaaaacga 942481 tcccctcatg gaaatgccgt ttgaattcag agccagagag caagggaaag gcctgacaag 942541 atatgtgggg gactcgtcga ataaaacata tgtgcagcca gctgactgga agaagatagc 942601 tgtggaaaac agaattttct tcgcctcagc aagtgaagcg gagagcgcgg gatataaaaa 942661 aaggcaaacg gcacctcaag aacatgtgcc gcttagaatt ctcagcatga atgatttgca 942721 tggcaaaatc gatcagcaat atgagcttga tcttgatgga aatggaactg tagacggcac 942781 gtttggacgc atggattatg ccgccgcata tttaaaagaa aaaaaggctg aaaagaaaaa 942841 ctcgctgatt gtgcacgcgg gagatatgat cggcggaagc tctccagttt cctctcttct 942901 tcaggatgaa ccgactgtag aactgatgga ggacatcgga tttgatgtcg gaaccgtggg 942961 aaaccacgaa tttgatgaag gcacggatga acttctgagg atcttaaatg gcggtgatca 943021 tccgaaaggc acaagcggat atgatggaca gaactttccc cttgtatgtg ccaattgtaa 943081 aatgaaatca actggagagc cctttttgcc ggcttacgac atcattaatg tggagggcgt 943141 acccgttgct tttatcggag ttgtcacaca gtcggcagct ggcatggtta tgcctgaagg 943201 aataaaaaat atcgagttta cagatgaagc aacagcggtg aataaggcgg ccgaagagct 943261 caagaaaaaa ggcgtgaagg ccatcgcggt tctcgcacat atgtcagctg aacaaaacgg 943321 caacgccatt accggtgagt ctgctgatct tgcaaacaaa acagattctg aaattgacgt 943381 gatttttgcc gcgcataatc atcaggttgt taacggtgaa gtgaatggaa aactgattgt 943441 tcaagcgttt gaatatggaa aagcgatagg tgtcgttgat gtagagatcg ataaaacgac 943501 aaaagacatt gtcaaaaagt ccgcggaaat cgtatatgtt gatcaaagta aaatcgaacc 943561 ggatgtcagc gcgtcagcca ttttaaagaa atacgaaaca attgcggaac cgattatcag 943621 cgaggtagtc ggcgaagccg ctgttgatat ggaagggggg tattcaaatg acggcgatac 943681 acctcttgga aacctgattg cggatggtat gagagctgcc atgaaaacgg attttgccct 943741 tatgaatggc ggcggcatac gtgaagcgct gaagaagggt ccaattacgt ggggagatct 943801 ttacaatatt cagccgtttg gaaatgtgtt aacgaagctt gagattaaag gaaaagattt 943861 aagagagatt atcaatgcgc aaatctcgcc ggtttttggg cctgactaca gcatcagcgg 943921 gtttacgtat acgtgggata aagaaaccgg aaaagcagtt gatatgaaaa tggcagatgg 943981 caccgagatc cagcccgatg ccacatatac attgaccgtc aacaacttta tggcgacggc 944041 gacaggagcc aaatatcagc caatcggact gctgggaaaa aatccggtga cagggcctga 944101 ggatttggaa gcgacagttg agtacgtgaa gagttttgat gagccaattg cgtatacaaa 944161 agagggaaga attaagcttg ctgaagccag tgatattgaa gaccctgtaa cagaagaccc 944221 gataacggaa gagcctggag atgatccggg gacggaggat ccgattaaag aggatccaag 944281 gccaggtgaa gatttgcctg atataaaaga aactccggga acagcaccgg ttcatcagct 944341 tccgccttca gccatttcga gattcaatga aataccaatc aacaacacaa aaaccgctga 944401 tactgctaat agcatcagca cattgccgtt acaaaccgag actgcggaaa gcgggtctga 944461 tcatcagctt ccggatacgt cagcgggcta ctataacttt atggtaatcg gtgcggcggt 944521 gacattgtca ggaacttatc tatatgtcag aagaaaaagg agcgcctcca gaacgtgaaa 944581 aaagttattc cactattcat cattgctgcc ggcctagtga tcgcaggcta tggaggcttt 944641 aaattgatcg atacgaatac gaaaacggaa cagacattaa aagaagcaaa gctggcggct 944701 aaaaagccgc aggaagcttc ggggacgaaa aatagcacag atcaagcaaa gaacaaagca 944761 tcatttaagc ctgagaccgg ccaagcgagc ggcattttag aaataccgaa aatcaatgca 944821 gagcttccga tcgtggaggg caccgatgct gatgatttag aaaaaggtgt cgggcattac 944881 aaggacagct attatcctga tgaaaacgga caaattgtgc tgtcagggca tcgggatacc 944941 gtgtttcgcc ggacgggaga gctggaaaag ggggatcagc tccgtcttct cctgtcatat 945001 ggagaattca catatgaaat tgtaaaaaca aaaattgtcg ataaggatga cacatctatt 945061 atcacgctcc agcatgaaaa ggaagagctg attctgacga cctgctatcc gttttcatac 945121 gtcggaaatg ccccgaagcg ctatattata tatggaaaac gagtgactta aaaagccgag 945181 gcagtgcctg cggcttttct tcatgaaaaa tatgtgcggc aaaggttttt catatcagca 945241 gggaaagggg cttcagcaac tatgagctcg tctgttatcg ggtgaaccgc ttgtacttta 945301 ttggcgtgca gtgcctgcct gtttagcagc ttgctcccgc ctccgtaaag cgagtctcct 945361 gtcaacggat ggccgaggct cgccagatga acacggattt ggtgtgttct gcctgtttcc 945421 agctctaatt caacgagcga cagccgttct ttcgcattgc tggccattac cttgaaatga 945481 gtgacggctg tttgcccgcc tggtgaaacc cggcgtcttg tcgggtgtga gcggtctctg 945541 ccgatcggtg aattaattgt cccttttttc gtccgtagct taccttcagc gatagcggta 945601 tacgtacgct tcagcgtctt tttctctaac tgctggtcta agatggcgtg tgccaaacga 945661 tgcttggcaa aaacgatagc gccagatgta tcctgatcaa gacgatggac gtggcgcacc 945721 ttacatgttt cgccatttat ctgataatga tacgcgatca aattagccag tgtgccggtt 945781 tgcccatcct cattcggatg cgtcgcgatg ccagcgggtt tattgatgat gagcatatga 945841 ttgtcctcaa ataaaatatc aagctcgcca tactccggaa tgaccgaaga tgcttcactt 945901 tcctgaagat caatgaacac gcggtctccc ttttttacaa tcatattgtt taagacggat 945961 tcgtgattga cctttatctg ttgatgggac atccagtctt gtatcactgg tttagaagct 946021 ttgagcgctg ttttgagtac ggaaaacagc cattggccgt cctgtttttc attgatgagg 946081 atctcaagcc ctctgccttt ttggttcatg ttaaatggct ccttttcgaa gcggaaggct 946141 gctgtttctc ataggaaaca cttaccttag ctttcgcgtt tttttctgtg ctattcttga 946201 gtaagactta ggatattcga tggcaagaaa ggtgattgac gtgagaattg tgaacgcagc 946261 aactgcagaa caggagagct ttatcaagga gctgtctatg gagctgatcc atgatgtatt 946321 tcctctttat ttctccgaac tggacattca gcgctttaaa aagaaaggcg ttctgtcttt 946381 aaataaccat tattaccaag gaacattaaa agaagcattt caaattatgg cttgtctgca 946441 aatgatacat attatcctga ccaagccttc gccgcactct gatttgagtg atcaggcgat 946501 ttttgaaaaa aacagcaaga tgctgaatga ttttgggatt tattttccgt ttgctttttc 946561 tgactttcaa aagaagacta acaaagcctt tttcggtcaa agaaggctga tataatcatg 946621 cggcaagggc ttttctattt ttagaaaagc tctttttgta tcagagaaat catatcataa 946681 aacctttcct ctaactccct ttttaaacgg ctcgtgtctg aacatactaa tgattgaaag 946741 gggtgctgac aatgagttca gttaaagata caatgacaac gcaggtggca accgtttctc 946801 cgaatcaaac gattcaggaa gcggcttctc taatgaaaca gcataacgtc ggggcgatcc 946861 ccgttgtaga gcaaggtgtt ttaaaaggaa tgctgactga ccgtgacatt gcattaagaa 946921 ctacagctca gggccgtgat ggccagacac ccgtttcaga agtgatgtca acagaactcg 946981 tatcaggaaa ccctaatatg agtctggaag acgcgtcgca gctgatggcc cagcaccaaa 947041 tccgccgcct tcctattgta gatcaaaaca atctagtcgg gatcgttgcg cttggagacc 947101 tggcagtcaa tcagatgtcg aacgagtctg cgggatcagc gctgacaaac atttctcacc 947161 aaaacattca ttaataagaa agagcttgca gtgtgcaggc tctttcttca cataaaacct 947221 tactttttga aagcagactt gtttcggggt atagtgagtg tatacatatg tctcaattcg 947281 tactaaagga gttgtaccca gtgattaaag cgttaatttt tgattttgac gggcttattc 947341 tagatacaga aacacacgaa tatgaggttc ttcaggaaat atttgaagag cacggctcag 947401 tgctgccgct atctgtctgg ggaaaggtca tcggaactgc tgcgggtttc cggccttttg 947461 aatatttaga agagcagatc gggaaaaagc tgaaccatga agagctcaca caattgagaa 947521 gagagcggtt tgccaaacgc atggaatcag aaaaagcgag acctggtgtc gaagcgtatt 947581 tgaatgcggc aaaggattta ggcttaaaaa taggccttgc ctccagctct gattataaat 947641 gggtgtccgg ccatttgaag caaatcggcc tgtttgatga ttttgaagtt attcaaacgg 947701 cggatgatgt ggaagaggtg aagccgaatc ctgaactcta tttattggcg gcaaagaacc 947761 tgggggtatc gccagcggaa tgtctcgcgt ttgaggattc tgtcaatggt tcgattgctg 947821 cgaaacgtgc aggcatgaag tgtgtcattg tcccgaataa agtaacgggt accttgatgt 947881 ttgaagacta tgatcacagg cttgaatcaa tggcggagat ggagctcgcc ctattgcttg 947941 atcatctgaa ctcacaaaac tagaaaggag cgagtaggtt gtctgagaaa ttagatttga 948001 cccggtttga aaagaaaatg gttatccgca atatcgaaga gaaagacatc gacaagatta 948061 tcgatcttca aaaggactgc tttccaggaa tggagccttg gaagcgggag catttaatca 948121 gccatttgga gcattttccg gaaggacagt tttgtgcaga attcgaaggt gaaattatcg 948181 gttcgtgctc aagtctcctg attaactttg atgaatatga tgaccgccat acgtggcagg 948241 acattacaga tgacggttat atcaccaacc ataatcctga cggcttgaat atgtacggaa 948301 ttgaagtcat ggtgcacccg aaatacagac gaatgaagat cggccaccgt ttgtacgagg 948361 cgagaaagga cttagccaga cgcttaaacc tgaaaagcat catcataggc ggacggattc 948421 caaactatca caaatatgca gaggaaatga cagcgagaga gtatgttgaa caggtgacac 948481 gccaccaaat ttacgatccg gttctttctt ttcagctgat gaacggcttt acccttatgc 948541 gaattaaccc gaactatctc ccggatgata cagcttcgat caagtatgcg acgctgatgg 948601 aatggaataa tgtcgattat ctaccgcagc agacaaaacg ctattataaa tcggcgttcc 948661 ctgttagaat ttgtgtgatc caatacgaaa tgaagaaaat ttattccttt gaggaatttg 948721 cgaatcaagt agaatactat gtcgatgttg cttccgacgc aagatctgat tttgcggtgt 948781 tcccggaaat tttcacaacc cagctgatgt ccttccttga ggaacggtca ccgagcttgg 948841 cggtgcagag aattaccgag tatacagaag attacatcag cctgtttact gacttggctg 948901 tgaagtataa cgtcaacatt atcggcggat ctcatttcgt cgaagaggaa ggcaagatct 948961 ataatatcgc ttacctgttc agacgggacg gaacgatcga gaagcaatac aaactccata 949021 ttacgccgaa tgaacgcaaa tggtggggga tcagcgcagg agaccaagtt cgcgtgtttg 949081 atacggactg cgggaaaatc gcgatccaga tctgttatga cattgaattt cctgagcttg 949141 cccggattgc ggctgataaa ggagccaaaa tcatctttac gccattttgt acagaagacc 949201 gtcaaggcta tctgcgtgtc agatactgtt cgcaggctag agcggttgaa aatcaaattt 949261 atacggttat ctctggaacg gtcggaaacc ttccgcaaac ggaaaacatg gatatccaat 949321 acgcccagtc aggcatcttt gccccgtctg attttgaatt cgcccgagac ggcattgtcg 949381 gcgaaacaaa cccgaatatt gaaatggtcg tcatcggcga tgttgacctg gaaattctca 949441 gaagacagcg ccaaaacggt acagtgcgcc agctaaaaga cagacgacgt gatatttatc 949501 atattcaata taaaaaataa ttcccaaaaa acccgcctga attggcgggt ttttttaaac 949561 aaaagcggaa ttgtttaggt gctttcttta aaataaaagt aaattgtata gtggatgtgc 949621 cttatggagt ttctgtattt tcgccatttc ctatatcata cagaaaacgg ctaggcttca 949681 cattgctatt gcaatggctg tccaagttgt ttcgagtgcg acctttatca gtacgatgct 949741 gagcattgtc actttgcctg ttttgctttg gaagctgcat cctctttctt cttgagaaag 949801 gggatgtttt attatttacg cggtttattg actctgaccc ggtctggctt tatattgaag 949861 gcagggaaat catcaccaag acatcacata aagagaaggt ctgtttcaat tgaattggca 949921 ttatagggaa cgctaatgaa atggagatga tggggatgga aaacattcag caaaatcagg 949981 gattaaagca aaaagatgag caatttgtgt ggcatgccat gaagggagcg catcaagcgg 950041 acagcctgat agcccagaag gccgaagggg cctgggtaac cgacacagac ggacgccgct 950101 atttggatgc gatgtccggt ttgtggtgcg tcaacattgg ttacggcaga aaggagcttg 950161 cggaggctgc ctatgagcaa ctaaaggagc tgccttacta cccgttaacg caaagtcacg 950221 cacccgcaat tcaactggcg gaaaagctga atgaatggct tggcggcgat tatgttattt 950281 ttttttccaa cagcggatcg gaagcaaacg aaactgcttt taaaattgcc cgccagtacc 950341 atctgcaaaa cggcgaccac agccgttata aattcatctc aagatatcgg gcataccacg 950401 gcaatacatt gggagcgctc tcagctaccg gacaggcgca gcggaaatat aaatacgagc 950461 ctttgagcca agggttcctg catgcagctc cgccagatat ataccggaat cctgatgatg 950521 cagacacgct tgaaagcgca aatgaaatcg accgcatcat gacatgggaa ttaagcgaaa 950581 cgattgccgg ggtcattatg gagcccatca ttacaggcgg aggcatccta atgccgccgg 950641 acggatatat gaagaaggtg gaggacattt gccggcgcca cggagccctt ttgatttgcg 950701 atgaagtgat ctgcgggttt ggacggacag gtgagccgtt cgggtttatg cactacggtg 950761 tgaagcctga tatcattacg atggcaaagg gaatcacaag cgcgtatctg ccattgtcag 950821 cgactgctgt gaaacgggac attttcgaag cgtatcaggg ggaagctcct tatgaccgtt 950881 tccgccacgt gaacacgttc ggcggaagcc cggctgcctg tgctttggcg ttgaaaaacc 950941 tgcaaattat ggaggacgaa cagctgattc agcgatcccg tgatcttgga gcaaagcttt 951001 taggtgagct tcaagctctg agagaacacc cggcagtcgg ggatgttaga ggaaaagggc 951061 tgctgatcgg aatcgaactc gtcaaagaca aattgactaa agagccggct gatgccgcca 951121 aagtaaacca agtggttgcg gcgtgcaaag aaaaagggct gatcatcggc aaaaacggcg 951181 atacagtcgc cggctacaac aatgtcatcc agcttgcgcc gccattttgc ctgacagaag 951241 aggacctttc ctttatcgtg aaaacggtga aagaaagctt tcaaacgata taatataaaa 951301 gtgaattatt aaaggagcac atgatgagtt ttcacaacca gccgatctta ccggctattc 951361 gcaatatgaa gcaatttgat gagtttttga acagttcatt ctcttacggt gttattcttg 951421 atattcatct cggccagctg aagggcgtga tcaaagaagc gcaaaagcac ggaaagaaca 951481 tgatggtgca cgtcgatctc attcaaggga ttaagcatga cgaatacggt gcggaattta 951541 tatgtcagga tatcaagccc gctgggatta tttccacaag atcgaatgtg attgccaaag 951601 cgaagcagaa gaaaatttat gccattcagc gcctgttttt gcttgataca agcgcgatgg 951661 agaaaagcat ggagtttatc ggcaagcata agcctgactt catcgaagtg cttcccggca 951721 tcgttccgtc actcattcag gaaataaaag agaaaacagg gattcccatc tttgccgggg 951781 gtttcatccg tacggaagag gatgtagagc aggcattgaa agcgggggct gtagctgtca 951841 caacatctaa taccaaattg tggaaaaaat atgaaaactt tttgacggaa agtgattgac 951901 accgctttca tgcactgata caattgcact aggttaatac attgtgatgg agaactcgga 951961 gaccacagca gctctttacg gcaaatgttt atgcacccgt aaagcggttt gttgtggttt 952021 ttttattctc ttcttctcta tcatgctttt taatcgtgac tttaggagga atgtgctatg 952081 acagcatttt ggggagaagt catcggtacg atgctgctta tcatttttgg tgcaggtgtt 952141 tgtgcaggtg tcaatttaaa gaaatcgctt tcattccagt ctggctggat tgttgttgta 952201 tttggatggg gattgggtgt tgccatggcg gcatacgcgg ttggcggcat cagcggtgcc 952261 catttgaatc cggcgctaac gatagcgctt gcatttgtag gagattttcc ttggaaagag 952321 gttccggttt atattgcggc gcaaatgatc ggagcgatca tcggtgcggt gattatttat 952381 ctgcattacc tcccgcactg gaagtcaacg gatgatcccg ctgccaagct gggtgttttc 952441 tcaacagggc ccagcattcc gcatacattt gcaaacgttt taagcgaagt gattgggaca 952501 tttgtccttg tacttggaat cttggccata ggtgcaaatc aatttacaga aggacttaat 952561 cctttaatcg tcggtttcct cattgtagca atcggtattt ctctgggagg caccaccggc 952621 tatgctatca atcctgcacg tgacttaggt ccgcggatcg cccacgcttt tcttccgatt 952681 ccggggaagg gctcatcaaa ctggaaatac gcatgggttc cggtagtcgg cccgatttta 952741 ggcggatcat tcggcggtgt attttacaac gctgcattta aagggcacat cacaagcagc 952801 ttctggattg taagcgttat attggttgtg gtattgttag gactctatgt ttatacgaaa 952861 tcacattctg ctaaaacatt atcaaattct aaatatattt aatcaaaggg gagacatctt 952921 atggaaacgt acattttatc cttagatcag gggacgacaa gttcaagagc gattctgttt 952981 aataaagaag gcaaaattgt ccactctgct caaaaggaat ttacacaata cttcccgcat 953041 cctggctggg ttgagcataa tgccaatgaa atttggggct ctgtcctcgc ggttatcgcc 953101 tcagtcatct ctgaatcagg aatcagcgct tctcaaattg ccggcatcgg catcacgaac 953161 cagcgcgaga cgacggttgt gtgggataaa gatacaggaa gtcctgtcta taatgcaatc 953221 gtttggcagt ccagacagac gtccggcatt tgtgaggaac ttcgtgaaaa aggatataat 953281 gataaattca gagaaaaaac agggctttta atcgatcctt acttctccgg cacgaaggtg 953341 aagtggattt tagacaatgt ggaaggcgca agagaaaaag cggaaaaagg cgagctgctg 953401 tttggaacga ttgatacgtg gctcatttgg aaaatgtcag gcggaaaagc gcatgtgacc 953461 gattactcca atgcctcaag aacactgatg tttaatattt acgatttaaa atgggacgat 953521 gaactgctcg acattctagg cgtaccgaaa tccatgctcc ctgaagtgaa gccgtcctct 953581 catgtgtatg cggagactgt tgattatcac ttcttcggaa aaaatatccc gattgctgga 953641 gcggcaggcg accagcagtc cgcattgttc ggccaggcat gctttgaaga aggcatgggg 953701 aaaaacactt acggcacagg atgtttcatg ctgatgaata ccggggaaaa agcaattaag 953761 tccgaacatg ggcttttgac aacaatcgct tggggcattg acggaaaagt gaactatgcg 953821 ttagaaggga gcatttttgt cgcaggctct gccatccagt ggcttagaga cggtttgaga 953881 atgttccagg attcatcgct aagcgaatct tatgcagaaa aagtggattc aactgacggc 953941 gtgtatgttg ttccagcatt tgtcggactg ggaacgcctt actgggacag cgatgtgcgc 954001 ggttcggttt tcggcctgac aagagggaca acaaaagagc actttatccg tgcgacactg 954061 gagtcattgg cttatcagac caaagatgtg cttgacgcaa tggaagcaga ttcaaacatt 954121 tcattaaaga cgctccgtgt agacggagga gctgtaaaaa acaatttcct aatgcagttc 954181 caaggagacc tgttgaatgt tcctgtggag cgcccggaaa ttaatgaaac gactgcactt 954241 ggcgcggctt atttggcggg tatcgctgtg ggattctgga aggaccgttc tgaaatcgcg 954301 aaccagtgga atctggataa acggtttgag cctgaattgg aagaagaaaa acgaaatgag 954361 ctgtataaag gctggcaaaa agccgtgaaa gcagctatgg cttttaaata aagtaatact 954421 atggtataat ggttacaagt taataagaac ggtcctgaga tgaggagaga ccacagcacc 954481 aaagtgtaag catgcacttt ggctgttgtg gtctcttttt ctatttaccg tgacaacaag 954541 gaggaaacgt aatgatgaat catcaatttt caagtcttga aagagatcgc atgctgacag 954601 acatgacgaa aaaaacatat gacctattta ttatcggagg aggaattaca ggagccggaa 954661 cagctcttga cgcggcatca aggggaatga aggtcgcact aagcgaaatg caggactttg 954721 cggcgggaac atcaagccga tcaacgaagc tggtacatgg cggcttgcgc tatttaaaac 954781 aatttgaagt gaaaatggtc gctgaggtag gaaaagagcg ggcgattgtg tatgaaaacg 954841 gcccgcatgt cactacaccg gaatggatgc tgcttccgtt tcataaaggc ggcacattcg 954901 gttcatttac aacatctatt gggttaaggg tttatgactt ccttgcaggt gtgaaaaagt 954961 cagaacgaag aagcatgctt tcagcaaaag aaacgctgca aaaagagcct ttggtgaaaa 955021 aagacggctt aaaaggcggc gggtactatg tggaataccg cactgacgat gcgagactga 955081 ccatcgaagt catgaaggaa gcggttaaat tcggggcaga gcctgtgaat tactccaaag 955141 tgaaggagct tctttacgaa aaaggcaaag ccgtcggcgt attaattgaa gatgtgctga 955201 caaagaaaga atataaagtg tatgcgaaaa aaattgtcaa tgctacaggc ccttgggtcg 955261 atcagctcag agaaaaagac cattcgaaaa acggaaagca tttgcagcat acaaaaggca 955321 ttcaccttgt atttgaccag tctgtctttc cgctgaaaca ggctgtatat ttcgatacac 955381 ctgatggccg gatggtattt gcgattcctc gtgaaggcaa aacatacgtg ggaacaacag 955441 acactgttta caaagaggcg ctggagcatc cgcggatgac aacggaggat cgtgattatg 955501 tcatcaaatc aatcaattac atgttcccgg aactgaatat cactgcgaat gacatcgaat 955561 ccagctgggc ggggctgcgt ccgctgattc atgaagaagg caaagatcct tctgaaattt 955621 cacggaaaga cgagatttgg acatctgact caggcctgat caccattgcc ggcggaaaac 955681 tgactggata cagaaaaatg gcggagcaca tcgttgatct tgtccgtgat cgcttaaaag 955741 aagagggcga aaaggatttt ggaccatgta aaacgaaaaa catgccaatc tctggcgggc 955801 acgtcggcgg ttcgaaaaat cttatgtcct tcgttaccgc gaaaacaaaa gaaggaattg 955861 cagccggttt atcagaaaaa gacgcaaaac agcttgcgat cagatacggc tctaacgtag 955921 atcgcgtctt tgaccgggta gaagcgctga aagatgaggc cgcgaaacgc aacattccgg 955981 ttcatattct tgctgaggca gaatacagta tagaagaaga gatgactgca acccctgctg 956041 acttctttgt ccgcagaacg ggacgtttat tttttgatat caattgggta agaacatata 956101 aagatgccgt tattgatttt atgagcgagc gattccaatg ggatgagcag gcgaaaaaca 956161 aacatacaga aaacctcaac aagcttttac acgatgcggt cgtaccgctt gagcaataaa 956221 tcataacggg ctgtctgcag cccgttattt ctttttacgt gccgaaaggg ggagatctca 956281 ggttatcaag tgacagaggc acccgcttca tataaaataa tggcataagc tgatacatag 956341 gaggacgaat atgacttgga gaaagagcta tgaacgctgg aaacagacag aacatttaga 956401 tctggaatta aaagagcgcc ttattgaatt agagggagat gaacaggccc ttgaggactg 956461 tttctataaa gaccttgaat tcggtaccgg cggaatgcgc ggggaaatcg gcgccgggac 956521 aaatcggatg aatatttaca ctgtgcgcaa agcatcggcc gggtttgcgg catacatctc 956581 gaagcaaggt gaggaagcga aaaaacgggg cgttgtcatt gcttatgatt cccgccataa 956641 gtctccggag ttcgcgatgg aagcggcaaa aacacttgcg acacaaggca tccaaacata 956701 cgtgtttgat gagcttcgcc cgacgccaga gctgtcattc gctgttagac agctgaacgc 956761 ttatggtgga attgtggtaa cggcaagcca taacccgcct gaatataacg gctacaaagt 956821 atacggggat gatggcggcc agctgcctcc aaaggaagcg gacatcgtca ttgagcaggt 956881 aaacgcgatt gaaaatgagc tgacgatcac agtggacgaa gaaaataagt taaaagaaaa 956941 aggcttaatc aaaatcatcg gtgaagatat tgataaagtt tatacagaaa aactgacgtc 957001 catttctgta catcctgaat tatcggaaga agtagatgta aaggttgttt tcacaccgct 957061 gcatggaact gcaaataaac cggtcagacg cggtcttgaa gcactcggct acaaaaatgt 957121 aacggttgtc aaagaacagg aactgccgga ttcaaacttc tccactgtta catcgccgaa 957181 cccggaagag catgcggcat tcgaatatgc cattaagctt ggggaggagc agaatgcaga 957241 tattctcatc gcgacagatc ctgatgctga ccgcctcggc atcgcggtga aaaacgatca 957301 aggcaaatat acagtgctga caggaaacca aaccggagcg ttgctgcttc attacctgct 957361 ttctgaaaag aaaaaacaag gcatcctgcc tgataacggt gttgttctca aaacgatcgt 957421 cacaagcgaa atcggccgtg ctgtagcttc ttcattcggc cttgatacga ttgatacgct 957481 gacaggcttt aagtttatcg gtgaaaagat taaggaatac gaagcatcag gccagtatac 957541 cttccaattc ggttatgaag agagctacgg ttatttaatc ggggattttg cccgcgataa 957601 ggacgccatt caggctgcgc ttttggcagt tgaagtttgc gcgttctata aaaaacaggg 957661 aatgtcattg tatgaggcgc tcatcaatct ctttaacgaa tatggttttt atcgtgaagg 957721 gctgaaatcc ctgacgctga aaggcaaaca aggagcagag caaattgaag cgattcttgc 957781 ttccttcaga caaaatccgc cgcagaaaat ggcgggcaaa caggttgtca cagcagaaga 957841 ttacgctgta agcaaacgga cgcttctgac tgaaagcaaa gaagaagcca tcgacttgcc 957901 aaaatcaaat gtattgaaat acttcctgga agacgggtct tggttctgtc tccgtccttc 957961 tggaactgag ccgaaggtta aattttattt cgccgtaaaa gggtcatctt tggaagacag 958021 tgaaaagcga cttgccgtcc tttctgaaga tgtaatgaag acggtggatg aaattgttga 958081 gtcaacagca aaataattca agtatgagct gggtcattgt aaatgatccg gctttttctt 958141 tttctcatcc aaaagtctga aagaaaatca tcctacaagt gaagcaatga aatacaaaaa 958201 actggtataa tcttaaatac aagatcaatg ccggagtgag aaacgtgagc aaaacgagga 958261 tggaaaaatt aaaaacgctg aaaacgattg cggaaacctt aaatcaaggg cacgatatca 958321 aagcaacact ggatgaggtt ttaaaagagt tgctgagtct gacaaacctt caatccggat 958381 ggatttttct gatcgaagaa gatgggtctt atacgttagc ggccgacgct tatctgcccc 958441 cggctttaag ccgcaaggaa aaagtgctga tgtgcgaagg ggagtgttac tgcctgacga 958501 aattcaataa cggagggctt agaaaagctg caaatatcat gaactgcaaa cgcatcgaat 958561 cagcagaaaa cctgcattgt tttgacacag aagggattac gcatcatgca actgtgcctt 958621 tagaagacgg ggacagaaga ttcggattgt taaatgtagc ggcggccgga aaaaccatgt 958681 ttgatgagga agagctgcat ttactcgagt ctgtcgcctt tcagatcgga acggcaatcc 958741 agcgtatgag gctttctgaa tatcaacaaa aaaatgctct tttaatggag cgtaaccgcc 958801 tcgctcagga gcttcacgat tcagtcaatc aaatgctgtt ttccgtcagt ttaactgcca 958861 aagctgcgaa gacactaaca aaagatgaaa atttacagca gatgattgat ttcatccaaa 958921 acctatcaca ggacgcgctc gcagaaatga aagcgttaat ttggcagctt cgccccggag 958981 gattggaaaa agggctggct gaagccatta aaagctatgg tgcgctcatt ggattgaaga 959041 tcatttttac acaaaaaggc tgtcctgttc tgactgatga gcaggagcat atgctatggc 959101 gtgtcgtaca ggaagcttta aataactgca aaaagcatgc cggaacggat acggcgtatg 959161 ttagtctgac tgcttctttg tgccatgcgg agctggatat catcgatcat ggggcaggat 959221 ttcgctatga agcgcatgcc ggtctgcctt cacttggcat aaaaggtatg aaagagcgag 959281 cggaaaaagc cggagctaag ttttggattg agtcagcgct tggaactgga acaaagctgt 959341 ccatcaggct tccgctaaaa agccgaaaag gaggggcggt atgaaaattg tcattgctga 959401 tgatcatcat gttgtcagaa agggtctgcg ttttttcttt gccacccagg atgatattga 959461 agtcgtcgga gaagctgcaa ctggattaga agccctccgt gtcatcgaag agacaaagcc 959521 ggatcttgtg ctaatggatt tgtctatgcc cgagatggac ggcattcaag ccattaaaaa 959581 agcaatacag caatttccgg atacgaatat cattgtgctg acgagctact ctgatcagga 959641 gcacgtcatc cccgcgcttc aggcaggcgc gaaggcgtat caattaaagg atacggagcc 959701 cgaggaattg gtgaaaacac gacaagtgca tggtggcgaa tacaagcttt ctacagctat 959761 tatgccccat gtgctgacac atatgaaaaa tcagcacgac ccggaaaaag aaaaatacta 959821 tcaattaact agaagggaaa aagacgttct gactgaaata gcgaacggga aaagcaataa 959881 agaaatcgca gcagccttgt ttatttcaga aaaaacagta aaaacccatg tatcgaatct 959941 tttagcaaaa cttgaagtgg ccgatcgcac gcaagcagcg cttttcgcag tgaaatataa 960001 cctgaatgga gagatctcaa aatgaacatg ttagtcataa atggcacgcc aagaaaacat 960061 ggcagaacaa gaattgcagc atcctatatt gcagctctgt atcacacgga tttgattgat 960121 ctaagcgagt ttgtattgcc cgtttttaac ggtgaagcgg aacaatctga actgttgaaa 960181 gtacaggagc ttaagcaacg cgttacgaaa gcggatgcga ttgtattatt atcgcctgaa 960241 tatcacagcg gcatgagcgg cgctttaaaa aatgccttgg attttctaag cagcgaacaa 960301 ttcaaatata agcccgttgc attattggca gtagcgggag gcggaaaagg cggcatcaat 960361 gcgctgaaca atatgagaac tgtgatgcgg ggtgtctacg ccaatgtcat tccgaagcag 960421 ctggtgcttg atccggtgca tattgatgtt gaaaatgcta cagtggctga aaacattaag 960481 gaaagcataa aagagcttgt cgaagaactc agcatgttcg caaaagcagg aaatcccggc 960541 gtctaaacgc cgggatttgt ttatgtgaga agggctattt gatcttcata agtcagctct 960601 gtggcatgat caatatatcg gagaagggaa tacagcatct tttctaaaac ggcgtaatcc 960661 tgttcaaaat gatacgcatg cagaaaatgc tcaattcgtt ttgataacaa atcgtcctct 960721 gtacgcacca ttaaaattaa taaattatcc cattgagaac gatgggtgta ataaagcgct 960781 ttatcgtaat cggcataatc catgaatcgc ttctcctttc ttgggtgaga agttcatgat 960841 tagtttatgc cgcatcctct gttattgacg gggcaaaact tgccgtctgc gtcagtaaag 960901 gggtagcaat atgagggaga cataaaatca aaatgcctga atgaagatat cgcttttggt 960961 aaacctatga gggaatatat tctgggtaca ggagactgaa aaaatgaaat ccctgccgta 961021 taccatcgca cttctttttt gcggattgat tatcgtgtca atggctgcaa aaggtcattc 961081 aacggacaca gacgagtccg ttcaaaagtg ggaacagctt gcctggagca aaattcagga 961141 tgaatataag ggcgcttcat tttctgatta tgcttatatg gggcgtacag aggtgaatga 961201 tcagcagact aaagatgtct ttcgggtgac agtcagacag aaagatgaca ctttttctgt 961261 tcgggccgaa gtctattttc atccggtgac aaatcatatg atcagcatca acgtctttag 961321 gctctaataa aaaactgtac agccgttaag gccgcacagt ttctgttttt agaaatatcg 961381 ttttgcaccg agatagcgct gtttccagta agagttgttc atattggaaa tgacaactcc 961441 ggaatcgttg gcatttatga attccccgtt gcctaggtaa attccgacgt gggaagggcc 961501 ggctttatat gttgaaaaga aaacgaaatc tccgacagca ggctggctaa ctgatttcat 961561 tgtgttccaa tatcccgctg ccgttaatct agatacggat gtgactttgt tcagtacata 961621 gtaaatgaat ccgctgcagt caaacccgga cggtgtcgtg cctccccagc gatacggaac 961681 cccaagctgc gctttagcgg ccgaaatcat tgtgttaatc ttcgcactcg ttgagctggt 961741 ggtgtttgaa gaaccggatg aagacgatga tgaagctttt ccggaaatga ccagcttttg 961801 gccaacctgc aagacatccg tttttaaatt gtttttctca cgaatctgct gagctgttac 961861 attaaatttt tgagcaatca cccataagga atcaccgctt ttcaccgtgt atgtagtcgt 961921 cgtgccggag cttgcatttg acgaagaaga cgacgatgat gaagagcctg aagatgcttt 961981 acctgtcagc ttcaatactt gtccaacgta aagcacatct gatttcagat tgttgatatt 962041 tcggatttgc tgtacagtca ggttatagtt gtttgcgatt ttccaaagtg aatcaccgct 962101 tttaacggta tatttagttg ttgctgaagt ttggttcgat ttggatgaat tgtctttaga 962161 agacgtatca gagccgcttg attttgtttt caacacctga ttcacgtaaa tggtgtctga 962221 ttttaagttg ttcaagacct tcaattcagc gatggacata ttgactttgt ttgcaatttt 962281 ccaaagtgaa tctccaagct gcaccttata tgttcccgta gaagatgaag aacttgaact 962341 cttattagaa ctgctttttg aactggagct tgaactctta ttagagttgc tttttttact 962401 ggaactagag cttgaagaaa cagtaccgga cacctttaat ttctgcccag cacgaattaa 962461 atcgctgctt agtccgttta attttttcag ttcctgcacc gtcattttaa actcatttgc 962521 gatcagccaa agtgaatctc cgcttttcac tgtgtaaaca gaacttccgc tcttcttggt 962581 tgttgagctt gaagtagatg aagaagtgct ggatttgctg cctggaatag taagcgtctg 962641 gccgatcgac agaacagtag tcgaaagatg attggcggat gtgagggccg ccacacttgt 962701 gttataggtt tgggccagtt tccataaaga atctccgctt ttgaccttaa tcgttgctgc 962761 ttcagctggt gtcactacta aagttgtgcc gacaatcgca gatgctgtca gccctgctgc 962821 taatttcttt ttcatcttag ctctcctttt tcccccaatg attttgcatt tgctgtttct 962881 tttttatatc ggcacatttg tctcatcgtt ttgccttttt ataaaaatag ccaaattatc 962941 ttaacaataa gggggaaaaa gggcataaaa aaagaaggaa tcttaatcta ttccttcatt 963001 tttaaaagct tcatgatatc ttctttgttt ttgacgaggt cgcgcagtgt gtatttgtct 963061 aaaactgcga ggtaggctaa aagcgcttca ttcagcacat gttttaagcc gcaaaccggg 963121 gaaataacac agagattctt gttcgcatca aaacattcaa caatattaaa atcgtcctcc 963181 gtttttctga caacctcacc gatgttgatg tcttcagggt ccatgcctaa tcgtatgccg 963241 ccgccccgtc cgcgtatcgt ttctacgtag ccgagctggc cgagcctgta tatgactttc 963301 atgagatgat tttttgaaat agaatacgtt tcggcaatct gttttatatt tgaaagttct 963361 ccgggacgct ctgcagccag aaaaatcaac actcttaatg aataatctgt ataattggtt 963421 aacttcataa taagacctca gaataagaca ttttctatat cttatcataa tcgattgaaa 963481 aatgaaaaaa aaggaattaa aaaacatgca cccagctggg tgcatgtttt ttgcttacat 963541 gtcattcggc ggattttggt ttttacggtt tttttcgatt tctgtgtttt gcattttgcg 963601 ttcaaatgta gacagataac gtgatgcaaa atccttaccg ccaaggccga aggataaacc 963661 aaaagcaagt gcgaagccgc taagaacgat gatgaacgcg gaattgacga ttgtcgcagc 963721 gacacccagc tgatccaggg ccataaagaa agcaagtgcg ataatcgtat atttagcaat 963781 aggcgctaaa gacttgaatt cctgaccttt tatcatgctt gcgagcactt ttctcaccaa 963841 ttctcctgcg taaaggccga gtccgagaat gaatactgcg acaaggacat tcggcagata 963901 cgcgatgatg ccggtggcaa tttctacgag gaagtgcagc cgaacaattt gaagcgcctc 963961 agctgtaaag agcagaatga caatgatttg cgcaatcata ccgacaactt gagacaagga 964021 cagctttgca ggcgttccgg cttccatgcc cattttccct aagacagaat caaagcctgc 964081 gcgatggagc agtccggaca ccatggattt cacccatttt cctgcccaga tacccgctaa 964141 tacaagcacg atggcaatca tgatgttcgg aagcatgttt aaaatcgtat tcagcataga 964201 gacagctggt tttgaaatgc cggcgacatc cagctgatca agcgctgaaa tgaccaccgg 964261 aatcataatg agcacataag cgattgttcc gatgactgct gaaaggcttg tgtcttttaa 964321 gtaaattgat aaacccatac gtgccgcgaa tctttcggtg ccgatgcttg caaggaaatt 964381 cgtaatgata tcacggacaa ggcgggcaac aagccatccg attaatacga taagcgccgc 964441 tgcaaataat ttcggcagaa aagcgagcac gctttccatc atatttgtaa aaggacctga 964501 aatgccgctg attttcaaag aagataagac ccctggcaga aaaacaagca gcacgagata 964561 aaagacaatt tgtgaagcgg tattgacagc ctggtgaata tcttttcctt cagacaccaa 964621 attccacttg cgcagtttgt cactcgtgtt cagcttcatc ccgatttttt tgacaaggaa 964681 gctcaaaaca gaagctgcag cccatcctaa cagcagaatg agtccggctt tcagcacgct 964741 tgggatcgca gctgcaatcg ccgaaagcat actgacaaac ggcgatgcca ctgttgtcag 964801 gtgcaaaatg ttaaagaata aaataaagac gatgatcagt gcgataaaat aaacgacctt 964861 gcttatgact ttttccgagg aatagcgtga aggctttttc ccagcaaaga gcttgtcgtc 964921 gatttttgtt ttgctgagtc ctttgtatac cgctttttca atgattttag caatagccca 964981 gccgattaat aagacgagta aagcaatgat tacgtttggc agcttactga gataagaaga 965041 aaacacgtct gctacattca attggtatcg ctcctttttc gtagtatggt gtgtgtttac 965101 ccacttatcc aataagcaaa cagatgaatg tgccggggga attttttctt gcccgagtga 965161 gactatcatc ttttgtctgg cgggctcata cattatagat aagtccaagt aggggggatt 965221 cggttgaacg cggaggagaa gaagggatta cagcgggcaa ttgaggaaat taccgaaatt 965281 gcaaaaggat tcggccttga tttctacccg atgagatatg aaatctgccc ggctgaaatt 965341 atttatacat ttggcgcgta cgggatgccg acaagattca gccactggag cttcggcaag 965401 cagtttcaca agatgaagct gcactatgat ctagggttaa gtaagatcta tgagctggtc 965461 attaactcag atccatgcta cgcttttttg ctggacagca actcactgat ccaaaataaa 965521 ttgattgtcg cacacgttct tgctcattgc gatttcttca aaaacaactg ccgtttccaa 965581 aacacgaagc gcgatatggt ggaaagcatg gcggcaacag ctgaacggat aaaacactat 965641 gaacaggttc acgggataaa agaagtcgaa tcttttttag atgcaatcct ttcgattcag 965701 gagcatatcg atccgtcgtt ggtccgacca aagctccaat ggagtgtgga tgatgaggaa 965761 gaggagattg aagaggcagc cacgccttac gatgatctat ggtctttaga tgaaaagaaa 965821 ccgaaaaaac aagtgaaaaa atcgaaaaaa ccgttcccgc cgcggcctga aaaagatatc 965881 ctgcttttta tcgaggagca ttcccgggag ctggagccat ggcagcgtga tatattaacg 965941 atgatgagag aggaaatgct ttatttctgg cctcagctgg aaaccaagat tatgaatgag 966001 ggctgggctt cctattggca ccagagaatt atacgtgagc ttgatttaac ctctgatgaa 966061 gcgatcgagt tcgccaagct gaatgcaggt gtcgttcagc cgtccaaaac aggcattaat 966121 ccttattatt tagggctgaa aatatttgaa gacattgaaa agaggtacaa caacccgacg 966181 gaggaaatga agaaaatggg cgtgcagcct gactccggcc gggagaaaat gtttgaggtc 966241 agggagattg aatccgatat ctctttcatc cgcaattatt taaccaaaga attagtcatg 966301 cgcgaggatc tttatttgtt tcaaaaacag ggccgagatt ataaaatcat cgataaacag 966361 tggaagtcgg tgcgcgacca gctcgtaagc atgcgggtaa atggcggttt tccatatttg 966421 acagtaaacg acggcgatta tatgaaaaat aacgaactct atattaagca ttggtatgag 966481 ggcatagagt tggatttgaa atatttggag aaagtgcttc cttatttatt ccagctttgg 966541 ggaagaagcg tgcacattga gtctgtgctt gaggataagg aagtcatgtt ttcgtacgac 966601 ggaaaaggtg ttcaccgcag atatttataa aaaagaggat gcagcgttct gcatcctttt 966661 tattttccag tttttaaaat cttaaatatg atgtttgcct ggtccgtatt gttaatcaat 966721 ccgcggaatt tttcttttcc ggggccgtac gcgtataccg gtacttcttc gccggtatga 966781 tcggtactcg tccatccgct gttggagcgg gtattaaaaa tcttgatgat ggctttggag 966841 gcccctttgc ttttgtcagc ctgtgcagct gcttcaacgc ttttgatttc ttcagatgtg 966901 actttcagat tggcatagcg ggcgagcaca tctttaaccg gcttgccttc actgattttt 966961 ttggccatga attcaggtgt tttcttagcg gagagaatcg gttctgcgtg ccaattcttt 967021 tccccgtttg cgccaatggt aaagccgccg gttgtatggt cagcagttgc aatcacaagt 967081 gtatgtttgt cttttttcgc aaattcaatc gcggctttat aggcctgttc aaaatcttta 967141 acctcgctca tggctcctac tgtatcattg tcatgggccg cccagtcaat ctggctccct 967201 tcgaccatca agaaaaatcc ttttttattt tggttcaggc gatcaattgc tgaaaccgtc 967261 atgtctttga gagacggtgt tttactgtca cggtcgagcg ctttagcaag ccctccatct 967321 gcgaaaagcc cgagcacctg ctgatcttta ttttttttca atgcttgttt agttgtcaca 967381 tagctgtagc cggcttgttt gaattccttt gtcaagtttc tgtccttgcg gttaaaataa 967441 gattttccgc cgccgagcag cacgtctatt ttatgtttgc cttttatctt gtcatccata 967501 tagctgttgg cgatttggtc catgtttttc cgtgattcat tgtgggcgcc atatgcggct 967561 ggagtggcgt ggttaatttc agacgtggcg acaagccctg ttgacttgcc ttgctgtttg 967621 gcctcttcaa gtacagattt cacttttttt ccgtttttat cgacgccaat tgcattgtta 967681 tatgtcttaa cgcctgtcgc taatgctgtt ccggctgctg ctgaatctgt aatattatag 967741 tcagggtcat ccggatgcgt catcatcatg cctgtcaggt tccggtcaaa ttctgttaac 967801 ttcgggttat tcggtgtgtc accgttattt ttcatggaac ggtaggctct tatgtaaggc 967861 gtccccatgc cgtcgcctat catcacaatg acatttctga tctcagcttt gtcttgtttt 967921 ttggcgctgg ccttttctgt ttgctgaagc tcagctccgg caaagattcc agctgtaagg 967981 acagaaacag cggcgattgg cagaagtttt gatttcatat tttgaaacaa actcattttt 968041 ttcatgcctc ctttaatgta ttccgtttat catgttaggg aaactttgtt aaatgcggct 968101 gttgatcatg taaacaataa gtaaagcctt gtaaggaaat gaaaaaacgc ttttcgttat 968161 cttgccttat ttgatgtaaa gcattcattt ttcagaaaaa tctttacctc tctgtctttg 968221 catgatatgt ttgtttaaat aaaaaaactg cggataacca cagctctcct cgaatatact 968281 ttatcactca tttttccgat atatgagccg accccgaaag tttttcattt atttccttta 968341 tgttgaaaaa catcccataa aacatgacaa aagcactcgt tttttgtcac ctttgcaatg 968401 aaaatgaaat atttaatacc cttaaaaact tttttttaga acgaataatt aagaaatttg 968461 tcacatgaag tcaagactat ttctgatggg aatctatcct tataatagaa atcaataaga 968521 ttaatttaaa aaaagagata catatatata gagttaacat ttggggagga aaatatgaaa 968581 aagcaaatca ttacagctac gacagcagtt gttttaggat cgacgttatt tgcaggagcg 968641 gcatctgcac aaagcattaa ggtgaaaaaa ggcgacacgt tatgggatct ttcaagaaaa 968701 tacgacacaa cgatcagtaa aattaaatca gagaaccacc ttcgttcaga cattatttat 968761 gtgggacaaa ctttatcgat taacggcaaa tctacaagtt caaaaagcag cagttcttct 968821 tcctcttctt ctacatacaa agtaaagagc ggggacagcc tttggaaaat ttcaaaaaaa 968881 tacggcatga caatcaatga actgaagaag ctgaatggct taaaatcaga tttgcttcgt 968941 gttggacaag tcctgaaact gaaaggttca actagttcaa gcagctccag ctcatcaaaa 969001 gtgtcatcgt cttcaacttc tacttataaa gtgaagagcg gagacagcct ttctaaaatt 969061 gcgagcaaat acggcactac ggttagcaaa ttaaaaagct taaacggctt aaaatcagat 969121 gtaatctatg tcaaccaagt attgaaggtg aaaggaacaa gcacaagcag ctcaaaacct 969181 gcttcatctt catcgtcttc aagcagcaaa acgtcatcta catcacttaa tgtgagcaag 969241 ctggtttctg atgcaaaagc gttagtcgga acgccatata aatggggcgg aacgacaact 969301 tcaggctttg actgcagcgg attcatttgg tacgtactga ataaacaaac aagtgtgggc 969361 agaacaagca ctgcaggata ctggagttct atgaagagca ttgccagccc gtctgttggt 969421 gatttcgtct tcttcacaac atataaatcc ggcccttctc acatggggat ttacattgga 969481 aacaacagtt tcattcatgc aggatctgac ggcgtacaaa tcagcagcct gaacaacagc 969541 tactggaagc ctcgttacct cggtgcgaaa agattctaat ttttagagaa aacccgttca 969601 ttggaacggg tttttttcat tagacggagc acaggcgttt tggttgctcc taaaaatgaa 969661 aatgtgataa aaaatccaag aacttttttt ctttcttatt ttcataaagg gcaatcgcgt 969721 aagcgccggc atagggcagc tgtacagact gataaggaat tctgatcatc tgtttctctg 969781 ctaactcacg ctttactgta gataaaggca gaaatgaaac tccgagtcct tccttgataa 969841 accgtttcgt tatatgtgtt tgagtgacct tcattgttct cacaaatgga aatgtcattc 969901 tgacttgacg gagcaagtcg tcccagtaat caggatgatt gtgggtcaaa agcaggtatt 969961 gttcgagcac ctctttggca tcaatttcgt tgtcttctat gaaacgctta tcgggcgggg 970021 caacaaggac gacagggtct ttgtataagc agtggcagct taaagaagaa gactgtacct 970081 ttaaacagct tagtccgata tctgcttccc cggctttaat cagtgacgcg atttccgctg 970141 attcgaaaat cgtaaccgcc atttctgttt ccgtattcat tgctgtgtac cgcttcatga 970201 cagaaggaag cactgtatct gcaataagcg gagaaaccgc gagctgtaag gtttgagagt 970261 agccttgtct cactctgtga agctctgcca tgctgttttc ataatcatca agaagcctga 970321 gcgcatacgg caaatacgcc ctgccttcat cagtcagctg gatttgcctg cctttacgct 970381 cgaacagctt gcagctgatt tctttttcta attgcttgat atgtacggtc acagtaggct 970441 gagataagaa aagcgtttcc gccgtttttc ggaagttctc atattttgca gcggtcacaa 970501 aggtgtgaag ccatttgaaa tccatttcta ttctccctct gattaatatt tttaattaat 970561 tccctttaaa atattgatta ttttttaaat attatattta ctataataac agaaaaggat 970621 agggggaata caaatggtac attacggatt aaagggaatt acatgtgtag aaacatccat 970681 cagccatatt gatggtgaaa aagggcgtct gatttacaga ggacatcatg caaaagacat 970741 cgcactgaat cacagctttg aagaagcggc ttatttgatt ttatttggaa aactgccttc 970801 aactgaagaa ttgcaggtat ttaaagataa gctggctgcg gaacggaatc ttccggaaca 970861 tattgagcgc ttgattcaat cactgccaaa caacatggac gatatgtcgg tgctgagaac 970921 ggttgtttca gcattggggg aaaatacgta cacattccat ccgaaaacag aggaagcaat 970981 ccggctgatt gcaatcacgc cttctatcat tgcatacaga aaaagatgga cgcgcggtga 971041 acaagcaatt gcaccttctt cccagtacgg acatgtcgaa aactactatt atatgctcac 971101 aggtgaacag ccttcagagg caaaaaagaa agcgcttgaa acctatatga ttctggccac 971161 ggagcacggc atgaacgcat cgactttttc ggcacgagtc acgttatcta cagagagtga 971221 tttagtgtca gccgtcacgg ctgctctcgg tacgatgaaa ggtccgctgc acggaggtgc 971281 tccttctgcg gtgacaaaaa tgcttgaaga cattggagaa aaggaacatg ctgaagcata 971341 tctgaaagaa aaactcgaaa aaggagagcg cttgatggga ttcggccaca gggtgtacaa 971401 aacaaaagac ccgcgggcag aagctttgag acagaaagca gaagaggtgg ccggcaatga 971461 ccgtgatctt gatcttgcgc tgcatgtaga agcagaagcg attcgtttgc tagaaatcta 971521 caaaccggga cgaaagctgt acacaaatgt tgaattttac gcagctgcag tgatgagggc 971581 catcgatttt gacgatgaat tgtttactcc gaccttttca gcaagccgaa tggtagggtg 971641 gtgcgcccat gtactggaac aggcagaaaa caacatgatt ttccgcccgt cagcgcaata 971701 taccggtgcc attcccgagg aagttctttc ataacatatt ttggcgttta ttcatttctg 971761 tcgtgtggta acgttcagta tcaaccacat gtctaggagt gatgaatgtg aacccaatgg 971821 acagacaaac agaaggacaa gaaccgcagc atcaggacag acagccgggc attgagtcaa 971881 aaatgaatcc gctgccgctg tcagaggacg aggattatcg aggaagcgga aaactgaaag 971941 gaaaagttgc gatcattact ggaggcgaca gcggaatagg gagagcagca gctattgcct 972001 ttgctaaaga gggggctgat atctccattc tatacttaga cgagcattcg gacgcagagg 972061 aaacacgcaa acggatcgaa aaggagaatg tccgctgcct gcttatcccg ggagatgttg 972121 gggacgagaa ccattgtgaa caagctgtgc agcaaacagt ggaccatttt ggtaaactcg 972181 atatcttagt gaacaacgcc gctgaacagc atccccagga cagcattctc aatatttcaa 972241 cagaacagct ggaaaaaacc tttcgcacaa atattttttc catgtttcat atgacgaaga 972301 aagctttgcc tcacctgcaa gaggggtgtg ccattattaa tacgacatcg attaccgctt 972361 atgaagggga tacggcgtta attgattatt ccagcacaaa gggtgcgatt gtttccttta 972421 cgcgttccat ggcgaagtcg cttgcagata aaggcatcag agtgaatgcg gtggcgcccg 972481 gtccgatttg gacaccgctt attccggcga cattccctga ggaaaaagtg aaacagcacg 972541 gcttggatac cccaatggga agaccgggac agccggttga gcatgcaggc gcctatgttc 972601 tgctggcgtc tgacgaatct tcctatatga cagggcagac cattcatgtg aatggcggcc 972661 gttttatttc aacgtaatca acgaaaaacc agctcaagag ctggtttttt gtgtggtgaa 972721 aaatttcaaa ataaaaaatt tgtcgatttt tctaacaatt ttgttttcat ttttgcaatt 972781 ttatatataa tattgagtag gagaaaggaa tgattcgcga ccagtacaaa tatagtagaa 972841 aaaaaagaat aatgaccatt gttactcatg aattcagaaa attcaaataa aatatataaa 972901 aatagatgat cgggagttga aggggaatga aagggagcgt ttttaggaag aaaagcattc 972961 aggatttaat cgctgcgacg agcggggaaa agtctttaaa aagagaatta ggggcatttg 973021 atttaacgtt gcttggaatc ggcgccatta ttggcacagg gatttttgtt ctgacgggaa 973081 caggcgcagt cacggccggt cccgggctga cgatttcatt tgttgtggcg gcgttggctt 973141 gtttattcgc cgccctgtct tacgcggaat ttgcgtcaag tgtgcctgtt tcaggttcgg 973201 tgtatacatt cacttatgcg acattgggag agcttatggc ctttattatc gggtgggatt 973261 taattttaga atacatgctg gcggtaagtg cagtgtcggt cggctggtct ggttatttcc 973321 aatcgttttt atcagggctt ggcattcatc ttccggttgc tttaacagcg gcaccgggcg 973381 cagtgaaagg cacctttacc ctgtttaatc ttcctgcatt cgtcattgta atggcgatca 973441 catatttgct ttatttaggc atcaaagaat caaaaagagt caacaatatc atggttatct 973501 tgaagatact ggttgttctg ctgtttatcg cggtggcagc cgtttacgtg aagccgcaca 973561 actggcagcc gtttatgcca atgggctttg gcggcgtgtt cagtgcagcg gcgctcgtat 973621 tctttgcttt tatcggattt gacgctgtat cctctgctgc ggaagaaacg aaaaatcccg 973681 cgaaggatct gcctaaaggc attattttct ctttactggt ctgcacgatt ttatatgtca 973741 ccgtatcagc catcatgact ggggttatcc cgtttgctca atttgcgggt gtggatcatc 973801 cggtttctct tgttcttcaa agcgcagggc aaaattgggt ggcaggcatc attgatattg 973861 gcgccgtgtt gggaatgaca acagttatgc tcgtgatgct ttacgggcag acccgcgtca 973921 tgtttgccat gtcgcgtgac ggacttgtgc cgggttcact ttctaaagtg catccaaagc 973981 acaaaacacc ttatgtagcc acttggtttt tcggaacgat gtcggcgctt ctcggctcac 974041 ttgttccgct ggatgaactt gcaaagctgg tgaacatcgg gacgttgtcg gcatttgtcc 974101 tgatttctgt ggcagttatc gttttgagaa agaaacagcc tgatcttccg agagctttta 974161 aatgcccggg agttcccgtg atcccaggcc tggcgattct gttctgcctg ttcttgattt 974221 taaatctggg atgggtgacg attgtccgct tcctagtgtg gctgttaatc ggcttggtaa 974281 tctatttcct gtattcaaga aagcattcaa aattaaatca ataacctttt gataaagaga 974341 gcggccatac aggccgcctc ttttctgttc ttggcaaatg aatctataga aatgaagaca 974401 aaaataagag ataatatagg ctggaaagga agtgacgttt attgtctgag caaaaaccag 974461 tccaatgggc ttcgaaaatt ggtttcgtca tggcagcggc cggctcggct atcggcttgg 974521 gcgcgatttg gaagttccct tacgtagcgg ggaccaatgg gggaggagcc ttttttctta 974581 tcttcgtgtt atttaccatc ctcttaggct atccgctttt ggtgggggaa tttatttttg 974641 gaagacggaa ccagacgaat gccattgatg catataaaaa agaagcgccg cgatcagctt 974701 ggtttcttac ggggtggatc ggcgtagcgg cgtgtttctt agtgctgtcg ttttacagtg 974761 taatcggggg atggattttg ctgtatatcg tgaaaacagc gtcaggatca ctgtccgggc 974821 tttctcaagc acagtatggc gctctttttg cttctattat ccaaaatccg gtgcagacgc 974881 tcgcggctca gcttgtcttt atggcactga ctgtactcgt tgtcgcaaga ggggttcaaa 974941 aagggattga acgggtaagc gcggtgatga tgccgatttt gtttttattg tttattctgc 975001 tcgttcttcg gtctcttacg cttaatggtg caatggaagg cgtaaagttt ctgcttgtgc 975061 ctcatttcgg cgatctgact ccggaatcca tattattcgc gctgggacag gccttcttta 975121 cgttaacact gggggtttcg gtgatggtga cctacagctc ctatttgccg aaaacacaaa 975181 atatccctcg ttcggcagcc tccattgtct tgatgaatat cattgtgaca ctcttggcag 975241 gtttggctat ttttccggcg gttttctcat tcggttttca gccaaatgaa ggaccgacat 975301 tgctgtttac agtgcttccg gccgtttttg aacagcttcc gttcggcaca ttgtttttta 975361 tcggctttct cgttgcattt ttatttgcag ccttaacctc agcattttcg atggttgaaa 975421 ttatcgttgc cacaatcgga aaaggggacg aaaagaagag aaaaaaactg tcatggacga 975481 gcgggctttt gatctttttg gtcggaatcc catgctgctt gtcttatggc gttttgagtg 975541 atgtgcacct atttggcaaa acgttttttg atattgccga ttttaccgtc agcaatgttt 975601 tgatgccttc aggcgctctg ttaatttctc tatttatccc gctgaaaatt tcgaaaagcg 975661 aactcttggc tgaaatgcga aatggatcaa atgcaggtaa agcattcttt tacacatggt 975721 tttatttgct tcgttttatc gtgccgcttg ccattattat cgtgttctta aatttaatcg 975781 gaattttatc attttaaaaa acaggctccg tttccggggc ctgtttttta tttaataaga 975841 tgatatcaac ggtgcccatg ccgttttcag tttttggatg ccgagcctga tgtcctcttc 975901 tgacaaaccg ccataaccga ttaagacaga agtaaaaggc gtctgttcta tatatgaggg 975961 agacacggga tagagggtta caccgtggtc agcggctgct tgtattgctt cttcctcact 976021 tgctggaaac aaaaggcgca gcagaatgtg aagccccgag ttcttaccga gaatctcaac 976081 ggtgtttccc agttcagagc gaatggcttc taacaggaca gcgtgttttt ttcggtataa 976141 gcttctcatt ctatttatgt gtttttgcca ctctccggtt tcgatgaagt ctgccagtgc 976201 caattgcgag tgggcagaaa cggtctgctt cattaactga acattgtttt ggatcggttc 976261 catgagttca gggggcacaa tcatgaagct gagccgcaag gaaggcagaa gtgactttga 976321 aaaagtgccc agatatatga ctctgccatt cggatcaaga ccctgtaaag acggaatggg 976381 atggccgctg tagcgaaatt ctccatcgta atcatcttct ataatgaatg aatttgtttc 976441 tgccgcccat gccagcagct cctgtctgcg ggtaatcgtc ataatggtcc caatcggaaa 976501 ctgatgcgaa ggagtcgtat acatgagata aggattctga cggtagagct catccggcag 976561 gacgccttct gcatcagaac aaatcggagt gacatccatg tgatttgctt caaacatcct 976621 tcttgaacgg tgaaagcccg gttcttcaaa gccgattttt gtacctggct ttagcgaaag 976681 gcaaagattt tgcagaagca cggtggttcc tgcgccgatg ataatctggc cgggttcaca 976741 atttactccc cgagacagcc tgacgaatcg ggcaatcatg tgcctgagtt cgtattctcc 976801 ttgagggtcg ccagaggtgt gaaacgatcc ggaatagcga tcaagacttt ttactatgct 976861 ttttctccat gcgttaaagg gaaagagggt cggatcaacg ctgccctgat ggaagtcaat 976921 agcaggtgcg tttttttgat gtaatcccgg ctgtacagac tgctgaaaat ggtcaggagc 976981 tgtcgggaat cctggttcta cttccgccgc gaaccagccg attttcggct tgcttttgac 977041 atagccctca gcagttaatt gctcataagc tcgttctata gttgccgtgc tgacatcgag 977101 caagctggag agcctgcgtt ttgacggaag tcttgttccc tttgtgattc gcgcatgtga 977161 aatttcttgt ttaaaaaagg tataaagctg ttcatacagc ggtgttttgc tctttttatc 977221 aagaaacggc gtaatatcca tctcatgtct cctttgtagc tggcatggtc attttttctg 977281 atattggcta tttggcaaat gccatttatt agctatgatc attgtaacga aaggaaaggg 977341 gattgagaag atgatccata tgaaacaatt aacctcgaaa gaagaatggg ctgagtcgta 977401 tccgattatg agtgaattga gaacagaact ggatatagag acgtatttac aaaggcttga 977461 agcctgtgtg cagaaagaat cgtatatgct gtttgcctta tatgaaaata cagcaatcag 977521 agcgctgtgc ggggctctgc cgagagtttc cattcataaa ggagagcact tgtggattgc 977581 ggatcttgtt acaacggcac cttgccgatc aaagggatac ggcaaaatgc ttttggatta 977641 tgcctcagac tgggcgagaa aagccggact cggttttgtc agtctttcat ctggccttca 977701 gcgtaaagac gcacatcgat tttatacaga taaaatgggt tttactatag aaagttattt 977761 gttccgaaaa ccggtataac gaaaaaagac gcctgaaaag gcgtcttttt taaaagccaa 977821 actgtaaatt cgtatctaca gatacaatgg tatacacaca aataatcaca aagagattaa 977881 ggatgacgcc gagcaggcct ggacctgtgc gccctctctt gatgaagagt tcaacaacgc 977941 cgaacggaac ggcagccatg gcgaacggaa gcatttgata ggaataaaac gtgacgttgc 978001 tgataatggc caaattcagc aacagcaggg acagaaccgc tgtcccgaca gagatccagc 978061 cgaatacatt gtgttcttta aaaattctta ccagttccat aattccacct cgccgacatt 978121 cgctgatttt acagatttat ttttcagcat gcgctggatt tccttggttg gccctgtaac 978181 gaccgaaccg tatacattga caccgttttt ctctacataa tctaatcggt tatctacatt 978241 caggtctttc cgttttgaaa tgacctgagc ccatttttcg tgtttggaca tgaatttcag 978301 ggcgttgata aactgatcgc cattcgactt gccttttgta ttaagggcgg ccaagaactt 978361 tgaatccttt ccaggatagc caagaggttc tgtggaagct gtcttatttg tgtttttctc 978421 tgtttcgatt gcgttccaca aaaagctcac atcatagcct ttgaatttgt tatacacgtc 978481 ttttgtcgga tatgcacggt catatgaaag gtagacctct gataccgttc cttcaggcaa 978541 tgtgcttaac gttttttctg cttttgcggt cgtttgttca gacttgtttg aaggatgtgt 978601 aaagtaatgg ccggttttat tcacttctaa gtcatagtag tttactgccg gcgcttttac 978661 tttgttataa aacatttcaa cccgttcatt ccctacggca gccgtcttcg tgccaatctg 978721 cttttgcagc gggaattccg tattcattcc aaatagcttc acttggcttt tcagtccgga 978781 agtatcaaca agaacattcg gcatggtcag ggctacagtg actgcggcag tttccataaa 978841 ctcattgccg gtgctgtgtt ttccacccat tccgtaatag aggtagcttc ccagcgtaca 978901 aagcggcaaa atcatcaatg tcgaaatgac ggcaagcaca gaaattcgca aataagactt 978961 gcgtttgccg taggctaaaa tcgctttttg tttttcagga ctgatgctga gatcccaatc 979021 gttatcgtcc tctagttcgc tgtcaatcag ttcctgatat acttcaagct tctcgagttc 979081 ttcctcaaat gcagtcattt cctggtcgct catttcccca tttttatatt gatcaaaacg 979141 ctttttaaat tcttcattca tcattaacac ctctattata aagtgctttc agccgctgtc 979201 tggcacgaaa taaaacactt ttaaaattcg cctctgaaat attcataata tgggatgctt 979261 ctttgtagtt taactctttt aaataatata gcgttaaggc ctcccgataa ttatcgggga 979321 gctcggacat ataaccagtc agcacttcct ttatctctac ctgatgggca ggactttgaa 979381 cagcattttg aaagaggctt ccgattaagt catcagaaat ggttacttct ttcttatgct 979441 ttctgacgta atcaatgaag gcgtttcgcg ccacttgaaa aagccagggc tttactttgc 979501 tgtgatcata ggagtgaatg tgtatgtatg cccgcataaa ggtttcctgc agtaagtctt 979561 cagcaagatg cttgtctttt gtcatggaga gcaggaacct gtaaacatca ttcatgtaca 979621 tttggtaaat ttcatcgatc gtcactgcct tttctcccct ctatgttata cacgcataag 979681 aaaggtttaa agttgcacat tacatgcaaa cggctttttt atacctaatc aaacaccatt 979741 actatatagt acccaaaaat ggccgcaaaa gatagtgcgg agaaaggttt aacatttttt 979801 ccagagggga aaagatagtg aaaaagtgaa ggagtggcac aatggaatat accagtatag 979861 cagatacagg aatagaagcc tccagaatcg gcctcggcac atgggccatt ggcggaacga 979921 tgtggggagg cactgacgaa aaaacatcga ttgaaacaat ccgcgccgct cttgatcagg 979981 ggattacact gattgacacc gcaccggctt acggcttcgg gcagtccgag gaaattgtcg 980041 gaaaggcaat caaagagtac ggcaaaagag accaggtgat tctcgcaacg aaaacggctc 980101 tggactggaa gaacaaccag ctgttccgcc atgcgaacag agcgagaatt gtagaggaag 980161 ttgagaattc tttgaagcgg cttcaaacag actatattga tctttatcag gtgcattggc 980221 ccgatccgct tgtgccaatt gaagaaacgg ctgaagtcat gaaggaatta tatgatgcgg 980281 gaaaaatccg ggcgattggc gtcagcaatt tttcaattga gcaaatggat acatttcgcg 980341 ccgtcgcacc tctccatacg attcagcctc catataatct gtttgaaaga gagatggaag 980401 agagtgtcct tccttatgcg aaagataaca agataacaac attattatac ggcagtttat 980461 gcagagggct gttaacaggc aaaatgactg aagaatatac atttgagggc gatgatctgc 980521 gtaatcacga tccaaaattc cagaagcccc gctttaaaga gtatctttct gctgtgaatc 980581 aattggataa gctggcgaag acacgttatg gaaaatcagt gattcacttg gctgtcagat 980641 ggatcttaga tcagccggga gcggatatcg ctctttgggg agcaagaaag cctgggcagc 980701 ttgaggccct atctgagatt acaggctgga cgctgaacag tgaagatcag aaagatatca 980761 atactatatt ggaaaatacg atatcagacc ctgtcggacc ggagtttatg gccccgccga 980821 ccagagagga aatataacaa aagctgaggg cgaatcctca gctttttggc gtttaaacga 980881 gagaaatctt aaaaattagt accaggtaat aaaaaatatt gttataatag atgacagaaa 980941 gaatcattga ttacgacaaa ggaagtgcga tatgtataag ttttgtgcaa atgctttaaa 981001 agttattctt tctcttcgcg gaggagtgaa ggtgtataac aaagaaaacc ttccggccga 981061 ttcaggtttt gtcatcgcgt gtacacattc cggctgggtt gatgtgatta cactcggagt 981121 cgggattctt ccttatcaaa tacactacat ggcgaaaaaa gagctttttc aaaataaatg 981181 gatcggttcg tttctgaaga aaattcatgc ctttccggta gatcgggaaa atcccgggcc 981241 aagcagtatt aaaacgccga ttaagctgct gaaagaagga gagatcgtcg gtatcttccc 981301 aagcggaaca agaacctctg aggatgtgcc tttgaaaaga ggtgcggtga cgattgcgca 981361 aatggggaaa gcgccgcttg tccccgctgc atatcagggc ccttcaagcg gaaaagaatt 981421 attcaaaaaa ggaaaaatga agctgattat cggtgagcct cttcaccagg ctgattttgc 981481 ccacctgcct tcaaaggaaa gacttgcagc aatgacagag gctttgaatc agcggattaa 981541 agaactagag aataaacttg atcagctata aggcgttctg agagattgtc ctgaaactgt 981601 gaaaataaga aaagcaccct atacaaggtg cttttcttat tatgcttcct gctggttagc 981661 tgtctccaga agttcttctt cttgaagctt tttcacttca atatatgcga cgtggtggcc 981721 gtcaatttca ttaatgatga attcgcagcc ctcttcgatg atggaatcat ctttttcaac 981781 atcgtatttt tgagtaagga accagccgcc gattgtatcg acttcttcgt tctctaaatg 981841 gatgcctagc aggtcgttta cttggtcaat taacactttt ccgtcaagaa tataatggcc 981901 ttcgccgatt ttgcggattt cgctaatttc atcaatatca aattcgtcgc ggatttcacc 981961 gacaatttcc tcaatgatgt cctcaaccgt cacaagcccg gcagtaccgc cgtattcatc 982021 agacaaaatg gccatgtgga ccctctcttt ttgcattttg acaagcaggt cttggatcgg 982081 cgcagattca atgacatgaa tgatagggtt gacgaattga gaaatggtgg aatcaacaga 982141 tacctcaccg ctgatgcagg cggtcagcac ttctttaatg ttaataaccc cgataatgtt 982201 atctttatcg ccctcttcca cagggtagcg ggtatatttt tcaatctgaa tgatgtccat 982261 catttcagaa atcttgatat catgcggaag gctgacaatt tcggtccgcg gaatcataat 982321 ttctttcgcg agcctgtcgt caaattcaaa gattttattc acatatttaa actctgattg 982381 gttgatttca ccgcttttat agctttcaga caaaatgatt cgcagctctt cttctgagtg 982441 agccagttcg ttttctgaaa cggtctccag gccaaatgct ttggtcaata accgtgcgga 982501 attgttcaaa agccaaatga atgggaacgc gatgcggtaa aaccaaatca gcggtttcgc 982561 aaacagcata gacactgctt ccgccttttg gatagcgact gttttaggtg caagttctcc 982621 gacaacaacg tgtaagaacg tgataatggc atacgcaaaa ataaacgata tgacatgtga 982681 aagggaacct ggaacgttca tttggacgaa aagcgggtga agcagccttt cgatcgttga 982741 ttcacctaaa acccctaatc cgatggaagt caatgtaatt ccgagctgac acgcagataa 982801 atattcatca agatgcgtgg tcactttttt tacggctatt gctgctttat ttccttccgc 982861 gatcagctga tcgatccgtg agcctctgat tctgataatg gcaaactcag atgccacgaa 982921 aaatgccgtc agggcgatta aaacagcaac taaaatcaaa ttcactatgt ccaattagaa 982981 ccttcactct agcaatgaga atgaaggtaa cacctcctgt tagataaaat ggttttaact 983041 taacagcagc ataaatgatt ggaacacggc gagcttttca ggcgggagtt tgcttttcag 983101 cttgtcacga tcctcgggct tcagccgttc aaaccgatgc aagattccgg agatgttttg 983161 attcatatga tcaatttcta atgccagatt tccaatttca tcatcaagtt tagctgaaga 983221 gggaaactgg ttctccagtc gatctttaat atcggacagg gccaatcgct gcttcttgca 983281 atctacaata aatataagtc gtttgagtgc attttcgtcg tagtaacggt aatttgaaca 983341 ggatctggcc ggcgtaagca gaccgagatt cgtataataa tcaactgtcc gtttcgttac 983401 tccggcgagt gccgctagtt cactgatgcg ataagtctca gccccatcta tatccctccc 983461 aaccatcacg ttatagttat gagaatagtt taatatatga acggtgtctt gcacaagttt 983521 attgtttttt ttagaccgga attggaagtt gtggaattca tcatctgatt gaagtaacat 983581 aggaagatag aattttcaaa tttttatatg cggaagggac agatgaaatt ggctgggtta 983641 tcccgggaag ttgaagaaaa cttaaataaa ggatcatgga ttcgcaagct gtttgatgaa 983701 ggtgcaaggc tgaagaagga gttcggggaa gaccaggtat ttgatttttc actcggcaac 983761 ccgattgttg aaccgcctga agcttttaag agagcgttaa tagaggaagc tgaaaaaggc 983821 agccacggat acatacaaaa ccaagggctt cttgcagcga gagaaaaagt cgcgcaattt 983881 ctgggctcgc gttttgaagc tgatttctca gcggagcgca tcgtcatgac ggtgggcgcg 983941 ggaggcgctt tgaatgttgc gttaaaaagc atcgtaaacc ctggggaaga ggtcattatt 984001 cttgcacctt attttgccga atataagttg tatattgaga actacggggg aaaagccgtc 984061 agctgcccgt tgacaagccg gtttgagatc gacattgaag cggtaaggca atcgatcact 984121 ccacagacga aagggctgat tctcaataca ccgcataacc ccacaggcac tgttctcagc 984181 cagaaaaata tagacgattt aggcgcttta ttaaaagaaa tagaagagaa gagcggccag 984241 acgatttatg tgctgtttga tgaaccgtac agtcaattaa tctatgatga agagctggca 984301 aatccgtttc aatcgtacca tcgtgtgata ttggccagct cattcagtaa agatctcggc 984361 atagccggag agcggctcgg gtatatcgga ttggacagcc gaatgccgga tgcggacctt 984421 ttgatcaacg cttttgtgta ttgtaatcga acgcttggat ttgtgaatgc ccctgtcatg 984481 atgcagcggg ctgtggcacg aatggatgat ttaagagtag acgcgagcgc ttataaagag 984541 cgccgggatt taatggtaga cattttaaaa gaagccggtt ttgaatttga aatgccaaag 984601 ggaggtttct ttgtttttcc gaaatcgccg attgaagatg aagttgcatt ttgcgtgcat 984661 gccgcccaaa aatacaaatt attaattgtg ccgagcagcg gttttggaat gagcgggcat 984721 ttccgattat ccttcagtgt gccgatcgag cagattaaaa actcacggga cattttcatt 984781 tctttatata aagattttgc ttaagaaggc aaagaaaaga aaacagtttt caaggctgtt 984841 ttctttttat atccgcaaaa tccttcctct tccaatccag acaggcgcag aattgacaag 984901 caggcatgca gttaaggctt tcttcatgat aaaagtctaa aaattaaaaa tcatttttgg 984961 aatgagttgt gttacaataa aatatacaat ttataatcaa actttgactt ttggaggtgg 985021 tatgatgggg ccctctgctt aggcaacaat acaccgcgta cctcaatgtt aaggaaaaat 985081 gattatatca ggaggtgact ccttatcctt tgttgagagg atagggttaa atggacgata 985141 ttgacagtct gattttaatt ggcgtgctca ttgctttaac cgcgtttttc gttgcaagcg 985201 agtttgcgat tgttagagtg aggagatcca gaatagatca gcttatcaca gaaggaaaca 985261 aacgggcgat actcgcaagg cgtgtcatta cagatttgga tgaatattta tccgcatccc 985321 agctaggcat tacattgaca tcaatcgggc ttggcgtact gggtgagccg gcctttgaac 985381 ggctgctgca tccactgttt gaaccgctcg gcttgccgga ctcggtttca catgcagtct 985441 cttttgcagt cgcgtacggc ttgatcacgt tcctgcacgt tgttgtaggt gaactggccc 985501 cgaaaacggt cgcgattcaa aaggcagaac agctgacttt actgatagcg ggccctttgc 985561 gtttattcta tttgctcctg tttccgttta tttggatcct caatggatcg gcgcggcttt 985621 tatgcgggat gttcggtttg aagcctgcgt cagaacatga tggttcccat tctgaggaag 985681 aactcaggat gctgttatct gagagtttaa aaaacggaga gattaatccg tctgaatata 985741 aatatgtgaa taagattttt gaatttgata atcggatcgc caaagaaatt atgataccgc 985801 ggaaggaaat ggctgctgtg tcaactgaga tgacgatggc cgagatgctt gaagtcatgc 985861 tgaaggaaaa atacacgcgc tggccagtca cagatggaga caaagacagt gtgctcggtt 985921 tggtcaatac gaagcatttg ttttctgatt tgctgtttat gacagaagaa gaacgaatga 985981 agatgacgat ccatccgtat gtgaggccgg tcatcgaagt gattgaaacg atcccggttc 986041 atgacttgct gattaaaatg cagcgcgagc gcattcatat ggctatattg tcggatgaat 986101 acggaggaac ctcgggactt gtgacgacag aggatattct tgaggaaatt gtcggagaga 986161 tccgagatga atttgatgaa gatgaacagc cgctgatcca aaagcttggc gacggccatt 986221 atgtgatgga tggaaaggtt cggatcgatc aggtgaacag ccttcttggc gcatcgattc 986281 aagaagacgt cgatacgatc ggcgggctga tattaaaaga aaacatcgat attgaggctg 986341 gtgaatccat tcgcatcggt tcatatacga taaaggtgct gaagatggac ggccgattaa 986401 tcaagcaaat cgatataaaa gaagaagccg gcaacacaac cgggattacg gcgcaccaca 986461 agctgccgct gcccgagcct gtgatgctga acagtgcaac cttgagcgag aaataagctc 986521 aaggtttttt tatattgtga ttgtccagcc gcaccaaaat gcaaaaagcg acccgcaaag 986581 tgtcaggacg atgtacaaga tgctttcttt tacacgtttg gccataagga gttgaatagt 986641 ttcaacgctg aatgtggaaa aggtcgtaaa ggcgccaaaa aaccccgtgc caatgataag 986701 cgagaccgaa gcatttgcaa cgtgaagtcc tgtaaatatt ccgagcccga gagctccgag 986761 aatattgact gtcagtatgc caatgggcag gctgagacct ttggttttgg cggttatgac 986821 attgccaagc cagaagcgaa gcattgcgcc aagtccgccc cctatgaaaa tacccgctag 986881 tgtcattttt cctgcagccc ctttctttgc tgaatgcctg ctatgcgccg tcccacaaaa 986941 acaccaatca gtgcaaatat gatccctgat atcaatgagg ctgccacata taaaagagcc 987001 aatgagggtt gtccttgcaa aagcatcact gtttccttag aaaacgtgga cattgttgtg 987061 aagcctccgc aaaagccggt gcctaaaaaa gccgacagca gaggccgttt tgccccgatc 987121 ataaaaaatc cggtcaaaat gcctaataga aggctgcctg ccgcattttc cagccaggtt 987181 gccgccggga actgaccggt gtgtatccat aagtttaatc cgtatcggag gcaggcgcca 987241 agcgcgcctc cgataaaaac cgcgctatat attttcatgt ttgccatcct ttatgatgaa 987301 atccgggtaa tctgtaacga tgccgtccac gcccatggct tgtaattttg ccgctgtctt 987361 ttgattgttg acagtccatg caaatatgtt taagccattt ttattgatgg agccgatcat 987421 cagacggtta agccgtgtgt gttttatatt gacatagttt gcaaaagagc ggaaggcctt 987481 catctgattt ctggacagca tgccaaagtt gggccttgta atgaccgctg tcggaatcga 987541 aggataaagc tcgcggaacc tttggacgga gcggaactga aaggattgaa caatattatt 987601 gatagaaaaa gaaaattgcc ctaatagctg tcccacctct tcttcaattc cgacttgaga 987661 cggatggcct tttagttcaa ttaaaaggcc gatttttttg tggtagcgct tgagcaccgc 987721 ttccagggtt ggaatacgct ctccttgaaa agcgggaccg taccagcttc ctgcatcgag 987781 tttttgcaat tcctccaagg taaaatcctt aacaaagccc gatccgtttg ttgttcggtc 987841 aaccctgtca tcgtgtatca caacaatctg cctgtctttt gtaagctgga catccagttc 987901 gatcatatct gcattcattt tcaccgcaag gtcaaatgcg gcaatcgtat tttccggagc 987961 gtagccggat gctccgcgat gggcaatgat gtacaagcta agtcagctcc tcgtatgggc 988021 atttctgtta ttgtatcaaa tccatatatg caccgcgata caaactggtg aattttttct 988081 gccatatcgg aatggtccgg gctgaggaat gcgtataact aaaaaaagac actcagcgta 988141 tcagaacaca tttcgtcaga aaattaggtc tttcgacatg ttcacaacaa aatatgatcc 988201 tttataatag caaaaaagga ggcgagatca tgggaaaagg gagaatcaga gtggaggaaa 988261 gaattaaagc cgaaacggat gctgaaatgc aaaaagcaac tctccttgat cagacacaaa 988321 cgaaaaaagg taagtgactg tccctattga atctggctga tagatgaatt gagaaatgac 988381 cccggcgttt cgccggggtt ttgtgctgca taagacattt aaatgaacat ccttacgaat 988441 attttagtat aataaacaat tgattgggat agaggggaga cagtcatgcc ggattatctg 988501 cagcagtatt ttacgcttga taacatcata caaatcggca tcagcttggc gattttgctg 988561 gtgtttctta tacttagaaa attattcaca agatattttt ttaacctgct ttttaatttg 988621 acaaaccggc cgaaaacaga aatttttaaa caggtggttc tggcgtttga taagccggcc 988681 agatggtttt ttgttgccct tgggctgttt ttagcgatcc ggtattcacc gtttttagat 988741 gagcaaatgc cggtcatcag caaaatatac cgctcactga ttgtggcgct cttgtgttgg 988801 ggtctttgta atttgaccgc aacatcgtcg tttatcttcc ataaggtgaa ccagcgcttc 988861 gagcttgaca tggatgacat tctggccccg tttttatcca aattgctccg ttttgtgatc 988921 attgcgctca gtgtcagtgt gatcgctcag gaattcaatt atgatgtcaa cggatttgta 988981 gcgggccttg gtcttggcgg actggctttt gcgcttgccg cgaaggatac catcagcaac 989041 ttcttcggcg gtattatcat tattactgaa aagccgttta caattggtga ctgggtggag 989101 acgtcgacag taacaggatc agtcgaggat attaccttta ggagcacgag attcagaaca 989161 gcacaggggg cgcttgtaac ggtgccgaac tctacgctgt cgatggaagc gatcacgaac 989221 tggacaagaa tgaccaaacg ccagattacg ttttccatcc atgtgtccta cgctacgccg 989281 attgagaacc ttgaacgctc cattcattct ctcagaacaa tgctcttaga gcatgagggc 989341 gttgataatg aaataatcat ggtcaacttt gatacgtttg ccgacagcta ctacaattta 989401 ttttttaact tctatacaaa aacgacggtt tgggctgaaa accttaatat tagagaggat 989461 atcaactata aaattattga gattttaggt gcagaaggcg ttcagtttgc atatcccggc 989521 caaatggttg ttgtcaagca aaagcacgaa agcgaccaat tccaggtgaa tctaaataaa 989581 gaggaaaagg aacgggctta aaagagagac ttcgtctgac agaggcggag tctttttcat 989641 ggtaaaataa gagaaaaagg cggtgttgag ttggaaacat tcaaaagtat tctacatgaa 989701 gcacagagaa ttgttgtgct gaccggagcg ggaatgagca cagaatcagg gatccccgac 989761 tttcgttcag cagggggcat ttggacggag gatgcctcaa gaatggaagc gatgagcctt 989821 gattattttt taagttatcc gcgtctgttt tggcccaaat tcaaagaatt gttccagatg 989881 aaaatgagcg gcagctttga accgaatgaa ggccatttgc ttttagctga gctggagaag 989941 caagggaagc aggtcgatat tttcacgcaa aacattgacg gtcttcataa aaaagcgggg 990001 agcaggcatg tgtacgaact gcatggttct atccagacag cagcttgtcc ggcatgcggc 990061 gcccgatatg atcttcccca tttgctggag cgggaggtgc cggagtgcac ggcggccgga 990121 aacaatgggg acatttgcgg aacggtatta aaaaccgatg ttgttctctt tggcgatgcc 990181 gtcatgcact ttgacaccct ttatgaaaag ctggatcaag cagatctttt attggttatc 990241 ggcacgtctc tcgaagtggc tccggctaga tttgtgcctg aggatgcaag cctgattccc 990301 ggcatgaaga aagtcatcat aaaccttgaa ccaacgtatt gcgacagctt gtttgacatg 990361 gtcatccatc aaaaaatcgg cgagtttgcc cgaagtttgg gcatgaaaaa gtgagccgct 990421 ttatgcgcct cactttttta ttcatgaaca ggaaccattg tgtcctctaa cactccgaag 990481 gaatagcctt tttcttttaa tttattgatt agtaccggca gcgcatttac agtagcagga 990541 agatcatgca tgagaattac atttgggcgg cttgaagagc tgtgttccat attctcaagc 990601 tgctgtaata cggcggtcac atactgtgaa ttccggtatt tccagtccat gctgtcgatc 990661 gtccaatccc agtacacaaa cccatctttc tccagattgc gaatttgtga ggcggttagt 990721 gacggcttgc ttccgtatgg cgttctgaca agatcggttt tatatcctgt aatgtcctgc 990781 agcgtgtcac gcgcctcctg catttctttt agcggagatg tcggtgtttg atagaacaat 990841 ctgttattgt gggtaacgcc atgtaaaccg agtgcgtggc cttccttttc tgctcttttc 990901 acagcctgct tgaattcgtt catccgcggt gacagcataa aaaacgtcgc ttttacatca 990961 gcgcttttca gtacgtcgag caagcgggtt gtaacggctg aagggccgtc gtcgaaggtt 991021 aagtaaaccg ttttatctcc catgttctgc tttgtctgca gatgttttat caggagatcg 991081 ggggagtcgt ttttcagctt aaggctttcc ttctcatctc gaagctggcc gtttgttgtg 991141 acagtgactt cctttgcttt cgttgaactg ttggaataac ccaaaatcac cataagcaaa 991201 agcagcacac ataaaactgc taaacttgca aatttaaaag caagcgaaac tgcagaagga 991261 gaagcctctc ctctcgtttg tcgcataaca atctctccat tggcataaaa tctctacata 991321 atgctgtaca gcaggcagct tatgaagatg ccttatgttt acaacctatg tattaccagt 991381 caagtataca ggaataaaac tggaaagcac atagaaaatt tgtcgaaatg tcagatttta 991441 aggaaaaaat aaactccttt ccgctataga tctcttgatc tttctgtttt tcagcttgtc 991501 caatatggta gaattagtga taatgacagc ttgaatgaca tcagggacat ctcgaaaagg 991561 gagggctttt atgaaggttt tagtcaatgg ccggctgatt gggcgcagtg aagcatcaat 991621 cgatttggaa gatcgcggtt atcagtttgg tgacggcatc tatgaagtga tcagggtgta 991681 caaaggagta ttgttcggct tacgtgagca tgcagagcgt tttttcagaa gtgctgctga 991741 aatcggaatt tcactgccat tcagtataga agatctcgag tgggacctgc aaaagcttgt 991801 acaggaaaat gcggtcagtg agggagcggt atacattcag acaacaagag gtgtggcccc 991861 gcgaaaacac cagtatgaag ccggcctcga gccgcagact actgcctata cgtttacggt 991921 gaaaaaaccg gagcaagagc aggcatacgg agtggcggcc attacagatg aggatcttcg 991981 ctggttaaga tgtgatatca aaagtctgaa tttactgtat aatgtcatga cgaagcaaag 992041 ggcctatgaa gccggagcat ttgaagccat tttacttagg gacggcgttg ttacggaggg 992101 tacatcctct aacgtttatg ccgttatcaa cggcacagtg cgaacacatc cggctaatcg 992161 gctcattctc aatggaatta cacggatgaa tattttagga ctgattgaga agaatgggat 992221 caaactggat gagactcctg tcagtgaaga agagttgaaa caggcggaag agatctttat 992281 ttcgtcaacg acggcagaaa ttattccggt cgtgacgctc gatggacaat cgatcggaag 992341 cgggaaaccc ggaccggtga ccaaacagct tcaggctgct tttcaagaaa gcattcaaca 992401 ggctgctagc atttcataaa tgaacgaaga aaagagcccg ctttttacag cggggctctt 992461 tttatttttt aacaaatcca atcaaaatgg agatcattgg cgatatatag aggaagaacg 992521 taaatgggat gtagtctatg actggaacac caagtgcgct cgccataaat gcgccgctga 992581 cgccccaagg aatcaatggg ttaattaatg ttccgccgtc ctctaatgat cttgtcagaa 992641 attttcgctg gatgtttcgt ttgtcatata aagatttaaa tgattgtccc ggtattaata 992701 tcgataaata ctgttcgccc gttgccaagt tgacgccgat gcttgagcag acagttgctg 992761 caacaagacg gccttttgag cggatgcctt tcatgacgcc ttccaatagt gcagaaatca 992821 atccgatttt ctccatcaat ccgccgagtg caaaagcaat cataatgaga gagacagagc 992881 ccatcatgga ttgcagtccg cctctgttaa taattttagc ggctgcctca ttgtcagttt 992941 cgaaagttgt gccattttgt aaagctgtca taaacgcctg caggctgctg tagggtacaa 993001 aaatagcagt caaaattccc gaggaaataa ttccggcagt cagaacgggg attactgata 993061 cccgtttcat tgccagcaaa acgactaaga gcggagaaag aagggcccac ggtgtcacgt 993121 ttgcagcatc ttttattccg gttatgacct gctgaatatt atcggttgaa gcagcgtccg 993181 ctgacactga tgaaccgaga aagtaaaaca gaacgacagt gatgagcaaa gctggaatgg 993241 ttgtgcccat catatggcga atgtgttcaa agattggtat ttcgcctatt ccggctgcaa 993301 agttggttgt gtccgacatc ggcgacattt tatccccaaa acaagcgccg catatgactg 993361 cgcctgctgt ccattcaagc ggaacgccag ccgcgctcgc cacgccgatc agcgctactc 993421 cgattgtgct tacagttgtc agacttgagc caacaagtgt gctgatgatc atacatgaaa 993481 acaaagcagt caacagaagg tggcttggtt caataaagga tagggcataa actgtcatag 993541 tcggtattgc gccgctgtac atccaggcgc cgattaagat gccgatcagc gctagaacaa 993601 taatcggctg tacgccgttt ttgatcccgt ctacaatccc tttttcaatg ctcttccagg 993661 gaaatccaaa ccataaagct gctgctgaaa gcatgacaac acttaaaaac agcgggatat 993721 gaggttctac atgaagcaag aataagcaag aaataataat gcacaacatg aatataaata 993781 aaccgacggc taacggaaac gtcagctttt tttgagaatc caaaataaca ccccatattt 993841 atctttaatg cttttgtgct tttgggcacg aaagcattat aacagaaaaa aacgaaaatc 993901 tatgtttttt cacaattatg aatataaaag aagtgagcac agggcgtgct cactttacaa 993961 tcaggacggg tatatccgat ttcgctgaaa gcttttcact tacacttccg aatattagct 994021 ttttcagcct gttttggtct ctgcttccgg ttacgatcat atcggcagaa atgcggtttg 994081 catgctcgat aattgattca gccggatcgc cttctaatat atcgatatct ccatctgcct 994141 gctgttcatt cagcatcatt ctggcttcgg cgatgacttc ttccgtacgg tcttcataga 994201 tcattggctc aggtgatgtt acatccgata tcagcggatc aggaacactt gtcatgcctc 994261 cgctgatata gcttgcctca gctgcgggtc tgggcgggtc gatgacggtc tgattgtctt 994321 tcatatcatg tgaatgggcg acggtaatag cggcatttac ggttttagca agatcaatgg 994381 ctgtcagaag cgctttctta ctattttcac ttccgtcaaa cgcaacaatg atacggtcag 994441 catggaacat ccttctcacc ctttcaaagc gtcttacaac actactaccc gaatttgagc 994501 acaattaacc ttttcctatt caagtaatga ttgacaataa aaggttttgt ttatatgatg 994561 ataaaaagat gaaatcagaa tggaaggagg gtttgctatg ccaaggaatt tgcgtgttta 994621 tcaaacagtt tcatattggc gcggcaaacc ttttgttctg ttttcgtgaa cggtttttta 994681 ggtcggaccg cgcgctgaaa agcgctgtgc gtaacatatc ggttaaaaaa ggcatggagc 994741 tgacgcttca tgcctttttt atatacaaaa tctaaggaaa gacaggtgta tgggatgtga 994801 agacaaatac agaggcgagg gcagttcgtg ccaaactgga tgaaaaaagc tgcaaggaaa 994861 aaatagaagg cggctgatga ggagatgggg atagatgttt tcagttttga aaaagcttgg 994921 ctggtttttt aaggcgtact ggctgcgcta tacgattgcg attgtccttt tattagcagt 994981 caatgtcatt gaaatgtttc cgcctaagct cttggggaac gccatagatg atatgaaagc 995041 aggggcattt actgcggaag ggctgctgtt ttatatcggt atcttttttg tgctgacggc 995101 ggccgtgtat atcatgtctt atttttggat gcatcagctg tttggcggag cgaatctgat 995161 ggagaaaatt cttcgtacga agctgatggg gcatttgctg actatgtcgc cgccgtttta 995221 tgaaaaaaac cgaacaggcg atttaatggc acgagggaca aatgatcttc aggccgtcag 995281 tttaaccaca gggtttggca tcttgacgtt agttgattct acgatgttta tgatgacgat 995341 ctttttgaca atggggtttt tgatcagctg gaagctgacc tttgccgcca ttatcccgct 995401 tccagtcatg gcgattgcaa tcagtctata tggaagtaaa attcatgagc ggtttactga 995461 ggcccaaaac gcgttcgggg cgctgaatga cagagtgctg gaatctgttt caggcgtgcg 995521 ggtgattcgc gcgtatgttc aggaaacaaa cgatgttcgc cggtttaatg aaatgaccgc 995581 tgatgtttat cagaaaaata tgaaagtggc ttttattgat tcactgtttg agccgacggt 995641 aaaactgctt gtcggcgcaa gctatctgat tgggctcggc tacggagcgt ttcttgtatt 995701 ccggaacgag ctgacgcttg gagagttagt gtcctttaac gtttatctcg gcatgatgat 995761 ttggccgatg tttgcaatcg gtgaactcat taatgtgatg cagcgcggca atgcgtcatt 995821 agatcgggta aatgaaactc tttcttatga aacggatgtg acagatccaa aacagcccgc 995881 tgatcttaaa gagcctggag atatcgtttt cagtcatgtc agctttacat atccaagctc 995941 aacaagtgac aatcttcagg atatttcatt tacggtgcga aaagggcaga ctgtcgggat 996001 tgcaggtaaa accgggagcg gaaaaacgac aattattaag cagcttttgc gccagtatcc 996061 tccaggtgaa gggagcatta cattttcagg tgtaccgatt cagcaaatcc ctcttgaccg 996121 tctccgcgga tggatcggat atgtgcctca ggatcattta ctgttttcac ggactgtaaa 996181 agaaaatatt ttatacggaa aacaggatgc aactgataaa gaggttcagc aagccattgc 996241 cgaagcacat tttgaaaaag atttgcacat gcttccgtcc ggtctggaga caatggtcgg 996301 tgaaaaaggc gtggcactgt caggcgggca gaaacaaaga atttcgatcg cgagagcact 996361 catggcgaat ccggaaatct tgattctgga tgattcactt tccgctgtag atgccaaaac 996421 agaggctgca attatcaaga acatcagaga aaaccgcaaa ggaaaaacga catttatttt 996481 gacacaccga ttatccgcgg tagagcacgc tgacctgatc cttgtgatgg acggcggcgt 996541 cattgctgag agaggcacgc atcaagaact gctggccaat aatgggtggt accgggaaca 996601 atatgaaaga cagcagctgt tcactgcgga agaaggggga gcaggggcat gaaaatagga 996661 aaaacgttat ggagatacgc acttctttat cgaaaattgc tgatcacagc cgtccttttg 996721 ctaactgttg ccgtcggtgc agaactgact gggcccttta ttggcaaaaa aatgatagac 996781 gaccatatcc tcggcattga gaaaacatgg tatgaagctg cggaaaaaga taaaaatgcc 996841 gttcagtttc acggcgtctc atatgtcaga gaggaccgat tgcaggagcc tgtttcaaaa 996901 gcaaaagaag cgcatattta tcaagtggga atggcgttct attttgttga tcaggctgtc 996961 agcttcgacg ggaatagaac ggtttctgac gggaagctga cgatcacaaa cggagacaag 997021 agccgggcat atgctgccga aaagctgact aagcaggaac ttttccagtt ctatcagccg 997081 gaaataaagg gaatggtgtt actgatctgc ctgtatgggg gcttgcttgt gttttcggta 997141 ttctttcaat acggacagca ttatctgctg cagatgagcg ccaatcggat tattcaaaag 997201 atgaggcagg acgtgttttc gcacatacag aaaatgccga ttcgctattt tgacaacctt 997261 ccggccggaa aagtcgttgc gcggattacc aatgatacgg aggctattag ggatttatat 997321 gtcacagtgc tttcaacatt tgtgacaagc ggaatctata tgttcgggat attcacggct 997381 ttgtttctgc ttgatgtgaa gcttgcgttt gtatgtctgg caattgtgcc gattatctgg 997441 ctgtggtcgg tcatataccg gagatatgcg tcatattaca accaaaaaat ccgctcgatc 997501 aacagtgaca ttaacgcaaa aatgaatgag tcaattcaag gcatgaccat tattcaggct 997561 ttccgccatc aaaaggaaac aatgagagaa tttgaggaat taaatgaatc acatttttat 997621 ttccaaaaca ggatgctgaa tttaaactcc ttaatgtccc ataatctggt caatgtcatc 997681 cgcaatcttg cgttcgtctg tctgatctgg cattttggcg gtgcgagcct gaatgcggcg 997741 gggattgttt ctatcggtgt gctgtacgcg tttgtcgatt atttgaaccg gttatttcag 997801 ccgatcacag gcatcgtcaa tcagttttca aagctggagc ttgcaagggt ctccgccggg 997861 cgtgtttttg aactgcttga agaaaagaat acggaagaag cgggtgaacc ggcgaaggag 997921 cgcgcgctgg ggcgggttga atttcgtgat gtgtcatttg cgtatcaaga aggtgaagag 997981 gtattaaagc atatttcctt tactgcgcaa aaaggcgaaa ccgtagcgct cgtcggccat 998041 accggatcag gaaaaagctc gattttgaat cttctgtttc gtttttatga tgcgcaaaaa 998101 ggtgatgtct taattgatgg aaaaagcatt tacaacatgt caagacagga actcagatcc 998161 catatgggta ttgtgcttca ggacccgtac ttattctcgg gcacaatcgg atctaacgta 998221 agtctggatg acgaaagaat gactgaagaa gaaataaaaa atgcactgcg gcaagtcggt 998281 gctgagcctc ttcttaagaa gcttccgaag ggcattaatg agcccgtgat tgaaaaaggc 998341 agcacgctat cctctggaga gcggcagtta atttctttcg ctagagcttt ggcgtttgat 998401 cccgcgatct tgattttaga tgaggcaacg gcgcatattg atacagagac agaggccgtg 998461 atccagaagg cgcttgatgt cgtcaaacaa ggacgcacca ccttcgtcat cgctcaccgg 998521 ctttcaacaa tcagaaatgc tgatcagatt ttggttcttg ataaaggaga aattgttgag 998581 agagggaacc acgaggaact gatggcatta gaaggccaat attatcaaat gtatgaactg 998641 caaaagggac agaaacattc cattgcataa cgctcaaaaa cccaaaacaa tcgtgttttg 998701 ggtttttggt ttatgtagtc aataagccag tccgacacgg tttccgacat actcacctgt 998761 aacgagctca cgatataaaa agtccgcagt atcgccgacc gaaatgcttg tgccgccctc 998821 aggcaaaacg ttacgctccg tacgataaac gccggttgct gttccgtccg ggaggtaagt 998881 ggggcagatg attgtccagt ctaatgatga ttctttaagc atttcgtata cttttgcatg 998941 ctccttggct gcgcgggtct gctttcgttt cgattcattt gtttcaaacc ggtattttcc 999001 cggttcatat cgggaatcta ggatccctgc ggtgccgatc gtaataagcc gtttgatatg 999061 ctgttcctcc ataacggaga gaatgtgtgc catagcagtt gacaaggtat catcaccatc 999121 tgtgcctaga cagctgatca cgatttcagc attctccatt atttttttca catcttctaa 999181 gcggcgggcg ttccccatga cagttctgtc ttttgaaagg ggaagatcag catgttgaga 999241 tctgatcaga gcgaaaatat caaatctttc atctgctgca gcttgtgtta aaaaggcttg 999301 tccgacgcgg ccgctggctc ctaataaagc gattttcatt aaaaaacctc ctcgcctttc 999361 attataaaag gatgttctca gtttgaacag cgcgggaaag aatacctgta caaataaaca 999421 gaacgatggg aaacatattc atgaatcatg gatacactta cgaattgaac cagctcccaa 999481 ttcacaatgg tgatgaatga caccccgatt ccctcccttt ttttctagga tatgtggagc 999541 aggaaaaaag ggtgacaaaa taaagagagc gcggaaaccg cgccctctat agccatatat 999601 tgaattgtta ttgaactctg ccgcccattt gctgctgagc gaaagatact aaacgttttg 999661 tgatttctcc tccgacagaa ccgttagcgc gagaagttgt gtccgctcca aggttaacgc 999721 cgaattcaga agcgatttca agtttcattt gatcgatagc ctgagctgcg ccaggaacta 999781 gtaagtcatt tgaagagttt tggttagcca tgtgtaaaat ctccttttta tttagtatgg 999841 ttgggttaac tggagttgca ccaatctgtg aacccttctc gggtgtcact gccgcctcgg 999901 cgtaacccaa tgctttgccg gcttgttact acgtattatg ttaaaatggc cggaaaatca 999961 tgcggagaat tgtgtggtaa atcttgagaa ataaaaaaag cttagccgtt taggctaagc 1000021 tagtcataaa tatgaaaaag catcagttca tgtatctcgt ttgtaagagc aggctcgtca 1000081 gcgcgggcgg gaaacaagtc tccccattca atctcaccgc tcttatgata gatgccttca 1000141 taatgggtcc ctttataata aaatgaaatt ttccatccgg gcagcttttc ttttgggaac 1000201 aaaggtttcc agctgaaatg agaaatcatt acggccacgc tccttacatt tggtatcaat 1000261 tgacctaaat aaaaacggct tatgttcatt gtatcattgt ttcagaacat cattgaagag 1000321 gcctaaatat gcagtttgtc ccagctttgg ataaagataa gcccgcttta ttaaaaaagc 1000381 ggacaggtta cgaaggccac aatgcttccg gagatgtgat tgccttctca gataaatatg 1000441 acgcgtattc aaaacttctt cgttttgtaa gagaatcaac atgatgcaaa tttggatgag 1000501 aaaaaatgct tcggcccggg cgcgaattcg cttcaaacat ccatacttta ccgttctgat 1000561 caatgccaaa atcgaaacca atctccccga taaatccctc gatatgatca tgaaggacat 1000621 ggcttgcagt cagtgccgct gcagaaagct ttttaatgac ctcaactctt tcagcgggat 1000681 catcgtatac ttccgcaagt gtctttacag tgccgccgtt agaaagatgt gttgtaatgc 1000741 tgttctttcc ggaaattttt acggcgattg ctgtcactgt ccattttcct tttctgtttt 1000801 tattggtatg gacacggaaa tccgctggtt tgccttgaaa ttcgatgaga tcaacacctt 1000861 gctgaatgag aaagtcggac gggttgtgat gtttttgaaa ttctgcaagg aatgaggcgg 1000921 catcggaata atcaattgat gtaaaagttt tggcgtcatt cgtatgcttt accgtcaggc 1000981 cgccatctgt tcttgtcagc tgataaatgc cggtgccgag tgctccattt gccggtttga 1001041 tatagacttt tttgtatgcg ccacagagct catctatcag ctccacagac ggtgtcagct 1001101 cggatctagg caaaaagggt gccgttcttg gatctttttc gagcaattga tgaacgttcc 1001161 atttattgaa aaacgtttta ttaaaccatg ggatctgata ttcatcgatc agcctctttt 1001221 ttgtatgttg caagagaagt gaatcttcaa tttttcggtt cggcaaacgg tcataaacga 1001281 cgttcggcaa tggaacgatt tttttctccc agccgttttc cctgtaaagg aggccttcaa 1001341 tcgtgccttc ctcccaattg atttggtgcg cgccaaaaac gaagcagtag cccccggctt 1001401 gctcgtgtaa cgtgacaagt ttagaaaaaa agagggaacg atccttaaat gggcgttcaa 1001461 gagatacagt aaaccctgcc gtaaagatgc cgactaacgg cccgatatgc actgtatgat 1001521 catgaatcag tatatctgcc ctgcttcggt ggggaagcaa aagctcatga aacagatttt 1001581 cagagagaag cacggtttgt tccagatgcc gtctgtaagc aacgtggcat ctgacaacct 1001641 tcgttccgaa tgcggcatgc aaaagtccgt cttgcttcag cgaagagggc agaaacaggg 1001701 tgttttcact ggttttgtct atgccgatca aaaaccgttt aggattcacg cggaagaact 1001761 cctttctggc tttgctcaga aaacagatat tggcagcgtt ttaggggaca agtgtacagc 1001821 tgttcttttt gctcgggaga gacacgcagg attgacttcc tgcctggttt ggaattgata 1001881 tctaaaatcc aaattctccc gtcctttgca agacatatat caagaccgag ttcaaacaac 1001941 ggcccatagc gctcgtcaag ataatacgga accgattggg taattgaaaa cacatcatct 1002001 agtaaaacca cttgctgttt tttcggtata tcttcaaacc aggagtcaaa tgtcagcgca 1002061 tcagatccgc ctgacaaatt ggccagcagc ccgtgtttgt atccgcgtct tactgccttt 1002121 ccgactgtat tccattcacc tgcttcgttt ttttccataa acagacgaat atcacaaggg 1002181 tattgttcct tatcttgaat gtttaagtaa ggctgaagca aatattgatg ctgaagcact 1002241 tttttgcacc atgttttaaa agaagtctgg ttggaaaacg tttttgtctg cttatccttt 1002301 ccgatgtgat aagtagcagt gatgtttttc ttgcccagct tcaaaagaat cacgcctctg 1002361 cctcccgcgc cgaatgccgg tttaaggatg caggcttttt ctttggataa aaaggagtga 1002421 atttgttcgt agcggctcac ctttatcgtt tcgggaatat agggattgat tacagagtgc 1002481 tgctgcaaat cgtgaaggac ggtccactta tcgggaagac cccgcccgat aaattccgtt 1002541 ttcggatatt ttttgagcca ctcaacgatt ggttttgctt tttgggaatg tgaatccttg 1002601 ccgtaaaaac agcgatcata aatataatct ggaatcgcca tttcagtttc gttccatgtg 1002661 ctgctggccg aatgatagac cgatgctttg acacgcaaag tgtcaggtga aatatcaaat 1002721 ggtgtaaacc ggatgaaacg tatgccgaat tcgggtgctc ttttggccag ttctgcggaa 1002781 taatccgctt catgctggcg ggataaggac ataaaaccga gtgttatcat ggtgagactc 1002841 ccccttttat tcaaaagctg ccggcgggtg tccgcagctt tacactaaat acatgtaaga 1002901 cgaacgcagc tgacggtatt ctactttaca gaatacgatt ctccaccttg ccctattcca 1002961 aaagaacaag ctgattttct aagaacagga atttgtctcc tcgtttgcta agtgattgca 1003021 tgagcctcta taatacgtat aggtacataa tctatatgaa aaaagctgaa gcacagatgg 1003081 aggaagatga ataggaatgg gtattgcagg aacctttatt tttatgatcg tgatcggcgc 1003141 tgccattgga gcggtgacca atcatttagc aattcaaatg ctgtttaggc cgtataaagc 1003201 gtactatttg tttgggaaac gagttccttt tacgcccggg ctgattccaa gacggcgaga 1003261 tgaacttgca aaacaaatgg gactgatggt agtcaatcat ctcttaaccc ctgaaggcat 1003321 taaaaagcgg ctcgtctctg atgcagccaa aacgcaggct cttcgagtgg gggaacagct 1003381 gattcaaaag ctgtcacttt ctgaagtgac agtaaaagaa gcgcttgaaa aagccgggat 1003441 gaagcgcccc gaaaaagctg ctgatgcatg gatcagcagc tggaccgatg ataagctgca 1003501 tgagcttttc cgccaatacg gggaccaatc gttaaaagag ctggtgccta tagaggtgca 1003561 ggaaaagctt gaggaaaaaa ttccgatgat ttcaggatat atattgtcac ggagtgtccg 1003621 ttattttgaa agtgatgaag gaaaaatccg tcttggcaat atgattgatg actttttaaa 1003681 agagcgcggc atgcttggaa gcatggtgca attgtttctt ggcaattcaa gccttgcgga 1003741 tcgcgtgctg ccggagctgc tgaaattctt gcgcaatgag gaaacaaata aattgctttc 1003801 tgatctctta aaaaacgaat ggggcaagct gagggagtat acgtttaatg aagcagatga 1003861 aaaatggaat gcaaaggcgc tcattttcag tttgaaacga agagtgctgc aagcattttc 1003921 gactgcccct ttcttcaaca atacgattgg cacgcttacc gtccgctatg aatctgagct 1003981 gacccagcaa atgctgccgg cactattaga caaattgctt gaaggtattt cgtccaacct 1004041 tgaaagtgtc ttaaaacggt tgcgtcttga ggaaatcgtc aaggagcagg tggatcagtt 1004101 cccggtggag cgtcttgaag aaatggtgct gtccatttca aaaaaagaat ttaaaatgat 1004161 tacctatttg gggggccttc tcggcggaat tataggcgcg attcaagcat tgtttgtcat 1004221 ccttttttaa gaagaaatgg tttttgatta atgaaaggag ctccatagtc tgttatagtg 1004281 gagtggtatg tcaaacggca atgatgaaag gagctattta caatggctgt taatttttat 1004341 gatgtagcgt atgatctgga aaatgcatta cgcgggagcg aagaattcac ccgtttaaaa 1004401 aacctttacg acgaagttaa cgcagatgaa tcagcgaagc gcatgttcga aaacttccgt 1004461 gatgtacagc ttagactcca gcaaaaacaa atggcaggag aagagattac acaagaagaa 1004521 gtgacgcagg ctcaaaaaac agttgcgctt gtacagcagc acgaaaaaat ttctcagctg 1004581 atggaagcgg agcagcgcat gagcatgctg attggtgaat tgaacaaaat cattatgaag 1004641 cctttagaag agctttacgg cagtgttgaa ggctaataag caaaatccct tcttggataa 1004701 gaagggattt tttattcact cagcaaactt ggaaatccaa tgaatctttt acctctccat 1004761 tgatgatgac tgataatgta tgaattcctt tgtaatgctt tctggtggtt aaatccttaa 1004821 aggattggat tcttgtgtat gacttcgttt cgttttttcg tatatttgtt tctgttattt 1004881 taaatacttt ctgatgacgc tggcctcttg cttttacaaa atcaattgcg tactcaattc 1004941 ttactttttg atccctgtct gaatgaatat agaaagaaaa ttcaaggctt tcgccaataa 1005001 ctatacgttt gggctggcat gttaaatcat gtagttgtat cgaatcagca ttttcataac 1005061 caaaaagcgc taaggcctgt ttatcaccct tttttaataa ggtccgatag gcgtgtttga 1005121 taatccagtc tgtatgggga tgtgttccgt accattgatc tgcgactttt ctcagtaaat 1005181 gaggatgcgt ttttgatata tcattaaggt tgttggccac gctttttctt acatataaag 1005241 actcgtcctg catcagcttc tcaaggatcg gcaatacggg ggaagggtcc gatttcaaag 1005301 ccggtatcga ttttccccat ggcaggcggg gcctgctgcc ttcgctcgca agtcttctca 1005361 cgtgttcatt tttatgctca gaccatgcaa gcaattgtgc aatcatcttt tcttgatcta 1005421 acagcaaaaa aggccttaca gcaaattctg aggtcgaata ttgcgtaaag gattccaatg 1005481 cctttattga ttcttcccaa tgcgctaacc cgtactgttc cacataatct ggaaataaaa 1005541 ttccgctgag tcctttaaaa tgaggggctg tatcccgtaa aattgtgagc gcttcaacgt 1005601 attgttttgg caaagtttcg tataaagaaa ctgtcacgcg gcgcatccgc tcttttaaag 1005661 tgagttcagg ccagtcctcc agccgtaatg tatccaagaa tctgtttttg ttaaaatcag 1005721 gataggatga ccttacatga tggatcaact gagatatcag ttcttcatta tatatttctt 1005781 ttaaatcagc catataaaca ccgctttttc gtttattatt tatattgtat gggaatgtac 1005841 gttctggatc aagtgtatag tcctaaaaat taacaactga tcctaccacg gatatacaaa 1005901 agttggttac tttttttagt taaaaaaacc cttgtcatcg gaaaggaaaa ctgagataat 1005961 aacattgaaa gcgcctacac ttacctattt caaatggata cggtcgcata tcatgccgtt 1006021 atatagaggg gataagcaac agagagtaag tgttcggagc gcatcattgg tcaaacaagg 1006081 ggttcctgat acatgatttt tcgtaaatcg aaataacgat attagggaga atggctgctt 1006141 cgatcgtatc ctatcaacaa gccatacata aagtctgctg agccaggctt tttttgcttt 1006201 aagaaaaggt tgttctaaac acagagacag ggtcatatcc tatacacaag tacagtcatc 1006261 aaggaggggg acatctctgt gtcaaaacaa ttgcttgcct taaatataga tggagcgctg 1006321 cttcggtcga acgggaagat tcatcaggca acgaaagacg cgattgaata tgtaaagaaa 1006381 aaagggattt acgtcacact tgtgaccaac cgtcattttc gctcagcaca gaaaatagcg 1006441 aaatcgctaa agcttgatgc caagctgatc acccatagcg gggcatatat cgctgagaaa 1006501 attgacgccc cgttttttga aaaaagaatt tctgatgatc atacctttaa cattgttcaa 1006561 gtgctggaga gctatcaatg caatattcgg cttcttcacg aaaagtattc catcggaaac 1006621 aagaaaaagg tgaattcgaa tttattaggg aaagcactca ttcatccgtc tgacccgatc 1006681 ttttatccag tccagttcgt tgaatcatta agcgatctcc tcatggatga gccggtgagt 1006741 gcacccgtca tcgaggtgta cacggagcac gacattcagc atgacattac agaaacgatt 1006801 acaaaagcct tccctgcggt ggacgtgatt cgcgtaaacg atgagaaact gaatatcgtc 1006861 ccgaagggtg tctcgaagga agcgggtttg gccctcgtcg cttcagagct gggcctgagt 1006921 atggatgatg tcgtggccat tgggcatcag tatgacgatc tgccgatgat cgaacttgcc 1006981 ggtcttgggg tagcgatggg gaatgccgtt ccggaaatta agagaaaggc agattgggtt 1007041 acaaggtcca atgacgagca aggtgtcgct tatatgatga aggaatattt ccgaatgcag 1007101 cagcgaaaag gatttcttga taagttccac atgaaacgtg tgtaaaaaag ccgctcgcgc 1007161 cctgacaggt gcggcggctt ttttgccgga ttgattttag cagtttattt ctgtacacta 1007221 aagaaagttt tgaatctgat aaattaggtg atgaagttgc aaattaaaat agaaggcata 1007281 catgatgacc gcctgcatcg gcctctgcaa aatattgcaa atttgtttta tgaagagtgc 1007341 gagcttgcgt atggcggaga ggagcccgca gattttgtca tttctttagc gttgtcacaa 1007401 acggatgagc atgtgacggt ttctggagaa gtgaagggta ctggcataaa ggaacagcat 1007461 acaaaattct tttctccaga catgactgaa aaagaagctt ttaagcaagt gaaaaacaca 1007521 atttcttatg tgtatctcaa tcttcttcag gcgcatacgg gcattacgca gaagtgggga 1007581 atcctcacag gaatccggcc cacaaagctg cttcataaaa aactgcaaag cggaatgtcc 1007641 aaggagcaag cgcatgctga gttgaaaaaa gactatttaa ttcatgatga aaaaatcatg 1007701 ctaatgcagg aaattgttga ccgtcagctg gcggcagtgc cggatttgta ccgagtaaag 1007761 gatgaagtca gcatttatat cggcattccg ttctgcccga caaaatgcgc gtattgcaca 1007821 ttccctgcgt acgctatcca aggacaggcg ggcagagtcg gctcattcct atggggactg 1007881 cattacgaaa tgcagaaaat cggtgaatgg ctgaaggagc atgatgttaa ggttacaacc 1007941 atttactttg gcggcgggac gccgacaagc attacagcgg aggagatgga tctgctgtat 1008001 gaagaaatgg tccgctcctt cccggatgtg aaaaacattc gtgagattac ggtggaggcc 1008061 ggtcgtcctg acacgattac agaagaaaaa ctcgccgttt taaacaaata tgacattgat 1008121 cggatcagca tcaatccgca atcctacgaa aacgaaacgc taaaggcgat cgggcggcac 1008181 catacggttg aagagaccat tgagaaatat catctgtcac gccagcacgg catgaataat 1008241 attaacatgg acttgattat tggtttgcct ggggaaggcg tgaaggagtt caggcacagt 1008301 ctttcagaaa cagaaaaact gatgccggaa tcccttaccg ttcatactct ttcatttaaa 1008361 cgggcgtcag aaatgacgag aaacaagcat aagtacaaag ttgccggcag ggaagaggtt 1008421 tctcaaatga tggaagacgc ggtagcctgg acgaaagagc atgggtacgt gccttattat 1008481 ttataccgcc agaaaaacat tcttggaaac cttgaaaacg tcggatactc tttgccggga 1008541 caagaaagca tctacaacat tatgattatg gaagaggtgc agacgattat tggcatcggc 1008601 tgcggcgctg ctagtaaatt tattgatcgg gatacaggga aaattacgca ttttgcgaat 1008661 ccgaaagatc cgaaatcgta caatgagcgc ttcgagcact acacggacga aaaaatcaaa 1008721 tatttagagc agatttttga aaaaacgaca aagcagcact gattacagtg ctgctttttt 1008781 tatccctgtt tttttgcggg ctgaacctca ggcttccatt taaatacctt gttcagcaag 1008841 cggtaaattc gttttgattc ctttgtgaca agcggtccca aaatcgccag aatgaggaca 1008901 tataatgcgg caaacggctt taatgtggcc gacagtccgc cggctatccc gagattcgca 1008961 acgataatcg aaaattctcc ccgcgatacg atcgtcagcc cgatattcga tgaagcctta 1009021 tgagaaagcc ctgcgcgtcg tcctgccacc attccggcga taaaatttcc cagaatggtc 1009081 aaaatcactg cacccaacgc aagccaaacc gcttcaccaa gcgaaaacgg atcgatgctg 1009141 aggccgaagc tgaaaaagaa catcgcaccg aagaagtcgc gaaacggaac aacgaggtgt 1009201 tcaatcctat cggaatgctc tgtttctgaa aagaccaaac cgagcagcag cgcgccgatt 1009261 gcttctgcta catgaatcgt ctctgaaaaa ccggcgataa aaaagagtgc tgcgaaaatg 1009321 acgataataa acacttcgtt tgagcgaatg tccaacagtt tgttcaacag cggcgggagt 1009381 tttcttgctg cgataaaaaa cagcagcata taaccgaagg cgatcaaaat ggacaagagt 1009441 gcactcccta cggatgtcgc atcacctagt ataaggccgg aaacaacgga cagatatacg 1009501 gcaaggaaaa tatcttcaaa catgatgatg ccgagaatca attcggtttc cgggttggcg 1009561 gttcttttta aatcaacgag cacttttgcg acaatcgcac ttgacgagat tgtgatgacg 1009621 cctgcgagga tgaggacttc cagaaaggaa aatccggtga taaacccgta aagcagtccg 1009681 aggctgaagt taatcaaaat ataaatcgtc ccgccgaccg cgattgattt tcctgatttg 1009741 attaacttcc cgacagagaa ttcgagtccg agatagaaga ggaggaacag tacgcccatt 1009801 cgcccgaaaa actcgatgat ttcactgctt tgaataaatg ttagatcaat aatccccatt 1009861 ttcggcgcgt gcggtccaac aagcattccc agcacaatca gaaacggaat aatcgaaaat 1009921 ttaattttat tggcgatcac actggcgatt gccacaagca caagtgcagt tccgacttca 1009981 aatacaagat ggtccatcgg ggctcacacg ccctctccag aaagaaaatc gtgaatcagt 1010041 ttcttcagat gctttctctc acctgagagg acaagggtgt cattttcttc aataatcgaa 1010101 tccgctccgg gatttaggag cttttcctgg ttgtgtttga taatcgcaat aacagtgaca 1010161 tcgtaattct ggcgaacatc aagctcaccg agtgtgcgtc cgatcgattt ggcgcctttt 1010221 tcgaccttaa accattcaat aataagatcg ctgaaggcca tttcgatgga ctccagagct 1010281 tgcggtttat agaccatgcc cccgagaata gctgcaattt gccttgcttc agaatcatcc 1010341 aatgaaatat ttgaaagaag ctcatccggg tcccggtcat taaaccggta aatttccctt 1010401 cttccgtcat catgaatgat aatcgtcatt ttttcgtggc ttcttgtttc gatttcaaac 1010461 tttttgccga tgcccggcag atcgttttct ttaatattca atgaaaatcc ctccgaatgt 1010521 agtgttggca gtatggggtg agttacaaat aaaacttgag caaattatat tcggaggtaa 1010581 ttagactggt atttgacagg gacggccaaa gccttttcca gcctgtttat cagcggttcg 1010641 tcaagtggtt tgacagagag ctgcctgaca gactgcgcca gcgggctgta ctctttgatc 1010701 agctcagccg ggtgcatgct gcccggcgat ggcgtttttg ccgattgtgt ttcctgcgga 1010761 tatgaagaca taggcacata gctgtcagtg cttgcttcaa actgggaagg cagaaccacg 1010821 tccgaagggg gaaagtacac cataaataaa cttaacagaa aactgatcag caatttatcc 1010881 atgttccttt cctcccttct catcaagata tcccttcttt ttcactatat aaaactttat 1010941 gtttccattc aaacaatatg catttttcag tatctattga ccttgaaaaa taaaaaggtt 1011001 tatttgggga tggcggggaa tgtataggag aaagaaaaaa gtaagcgcat acatggaggt 1011061 gcttttaatg gagtttgttc aatatgcatg taatggggcc gttgcagaga ttatcctgaa 1011121 tcggcctgat gcccatcacg ccctgaatga acagatgctg tctgaattga aggaggcagt 1011181 cgaaatggcg gctgcaagcg aggcgctcat cgttctcctg agaggaagcg ggaaaggctt 1011241 ttcggccggc ggtgatatca ggatgatgac gtcagagcat gaccctgacc aatttaaacg 1011301 gctgatggat acgattgagg ctgtcaccct gaatttatat cagatgaaga aagtgacaat 1011361 tgcagccatt catggtgctg ctgcgggact gggcctgagt ttggcgcttt gtgcggacat 1011421 tgtgctcgct gaaaaaaacg ccgttctcgc gatgaatttt atcggcattg ggcttgttcc 1011481 ggacggcgga ggacattatt tgctgaagaa aagaatcggt gaagcaaaag cgaaaaaact 1011541 gatttggagc ggaaaaaaac tatctgcctc ggaagctgcc gatatggggc ttcttgatgg 1011601 gacatttgcc ggagaccctg ccgaaggcgc aagacccatt atcgaaaccc tgttggcctc 1011661 ccctcttttg gcgatgatcg aaacgaaagg tatttttcaa agcctccaaa ttgaagaact 1011721 gaaaaaagtg ctatcccttg agcgcagcgc ccaagagaga atgagaagga ccaaggatca 1011781 ccaagaagga atccgtgcct ttttagaaaa acgggagccg aagtttcaag cgtaacagat 1011841 cagccggaaa gctgatcatc tgtgaaacaa aatcagcttt ccggctgcat tgactaaacg 1011901 atgagtatga ctatgaagct ctttttcttt taagagggct tcaccatgcg tttttgccgc 1011961 ttcttcatgt tctgcctcga attgctcgtt taccagcgtg ttccccgaag gatcaaatac 1012021 ggtaaggaaa taatcagcca tcaggtttct cctccatttt aaggtttatc agtctttctt 1012081 catttatatt ctaaaaagga aatcaaaatc ctttattatg ctttatccaa aattagtata 1012141 taatgggtca gggaaggagg agattcagtg cttacaattg atcacgtaac gaagacattt 1012201 ggagattata aagccgttga cggattggac ttagatattc cggaacagca aatgttcggt 1012261 ctattaggcg caaacggagc gggaaaaaca acaacgtttc gcatgatcct aggattatta 1012321 agcattacgg agggctcaat cagctggaag ggccgtcctg tgaattatca tatcagcaac 1012381 aaaatcggtt atttgccgga agagcggggc ctttatccga aaatgaaggt aagggatcag 1012441 ctcgtctatc ttgccagatt aaaagggatg gagaagcgag aggctgtaaa agagctcggg 1012501 acatggcttg aacgcttcaa tattacagat tacgagaata agaaggtgga agagctttcg 1012561 aaggggaatc agcagaaaat ccaattcatt tcggcagttt tgcataagcc ggagctcctg 1012621 attcttgatg aaccattcag cggcttggac cctgtcaatg ttgagctgct aaaagaggcc 1012681 gtgatctcgc tgaaaaacag cggtgtttct attttatttt caagccatcg gatggaacat 1012741 gtggaggagc tttgtgagaa cctttgcata ttgcagaaag gaaaaccggt tgtacaaggc 1012801 aagctgaagg agatcaagcg ttctttcggt aaaaagaatg ttaccattca ctccgatgac 1012861 gatctgcgct ttttgcagtc ccatgaaggc attcttcaat ggaaggaaac ggcagacggc 1012921 gtcaagctgc agattgccaa tgaagacatt tctcaagaga tttttgcgat gctccaagga 1012981 aaagggttta tcagaaagtt tgagcttgaa gagccgtcac tgcatgatat ttttatagaa 1013041 aaggtggggg ccgtctatga ataaattttg gatcatgctt tctcatacat acaaaaataa 1013101 gattatggca aaatccttta ttatttcgac tgtcatcacg gtgctgcttg ttttagttgt 1013161 aacgaatctg gagtcgatca tttctttgtt tcaaggtgac gatgcgaaag aaaaaatcgc 1013221 cgttgttgat gaaacaaacg aattatatcc ggttttttct aagcagctga aagcggtgga 1013281 tacagacggc gatcttgatg tgaagctgtc gaagcaatcg gaggatgagg tcacaaagca 1013341 agtcaaagat gaatcactcg atggcatgct catcatcaaa cgagatgaaa aagggaccat 1013401 ttcaggaaca tataaagcgt taacgatttc tgatgaaagc acgtatcaaa cactgcagca 1013461 ggcgctgacg caaaccaaaa cagctgtcgg aacagcggag ctcggcgtgt cgcaggaaac 1013521 gattagcagc ctttatgcgc ctgttactgt ggggcagaag gcgctgaaag aaggggcaaa 1013581 gtctgaggaa gagcttggcc agacggtagg gcttgtttac attatgctgt tcgtcattta 1013641 tttctcggtg attatgtatg ccagcatgat agcgatggag gtcgcaaccg aaaaatcttc 1013701 gcgagttatg gaaatcctga tctcaagtat gccgccgatc cagcaaatgt ttgcaaagct 1013761 gcttggtatc gggcttgtcg ggatcacaca gcttgctatt attataggag ccggctctct 1013821 gtcgcttaag ctgaaccaaa agagcgaaac ggcttcatct gtcggcggat tccttaattt 1013881 gaccgacgta tctgcaacca ctgtcatcta tgctgtcatt ttctttttgc tcggatactt 1013941 tttgtacgcg acacttgccg cgtttctcgg cagtgtcgtc agcagaatag aggacgtgca 1014001 gcaaacgatc acgccgatga cgcttttggt tgtcgccggt tttatgatcg cgatgttcgg 1014061 tttgaatgcg cctgacgcag gatttattac ggtaacttcg tttattccgt tctttacgcc 1014121 aatgattatg ttcctgcgcg tcggcatgct tgatattccg ttctggcagg cggctgtcgg 1014181 aatcggaatc acactgctca ccattgtcat actggccgtt atcggcgcca gaatttataa 1014241 aggcggtgta ttaatttacg gcaattcaag cgcgttcaaa gcgatcaaac aagcgctacg 1014301 tttagcgaaa aactgattgg aaaacagcct ggggattctc aggctgtttc tttattgaca 1014361 gaacgtgcat tcgcaagaat tcggtgctaa aataagggta cttcatcctg gaaaggagca 1014421 gaatgttgac tgatctaacc tttattcatg cggcagatct tcatcttgac agcccgtttt 1014481 acgggatatc gcatctgccg gagccgattt ttgcccggat taaagaaagc acgtttgcaa 1014541 gcgtgagaca tatgatagac gccgcagtga gagagcacgt tgatttcatt ttgcttgcgg 1014601 gagatctgtt tgatgaagcc aatcgaagct taaaggctca gctctttttg aaaaaacagt 1014661 ttgaaagact cagagagtgc ggaatttcgg tatacgtcat ctttgggaat cacgatcatc 1014721 ttggcgggga gtggacgccg attgaatggc ctgagaatgt ccatattttt tcgtccgctg 1014781 ttccagaaga aaaatcgttt tttaaagaag gcaggcgcat agcaagcatt tacggcttca 1014841 gctatcaagc cagagcattg atggaaaacc aagccgcccg ctatcggaga tcaactgacg 1014901 caccgtttca tatcggcatg ctccacggca cgctgtcagg atctgaagga cacgatccgt 1014961 attgcccgtt tacacatgac gacctcgtga aaagcgggat ggattattgg gcgcttggcc 1015021 atatacataa acgccaggtt ctatctgccg agcatccggc agtcatttac ccgggaaaca 1015081 cgcaagcacg ccatataaag gagacgggag ataaaggcta ttatctcgtt catgtgacaa 1015141 acggagatat atcttatgaa tttcagagag cgcatgatgt cctgtgggaa aaagcggcgg 1015201 ttgatgtgac ggaggcaaag aatatgacag ccctcttcca aatggtggag gacacgtttt 1015261 cgaagctgcg gaaaaagggg agccctgttt gtgtaaggct tgttttacaa gggacggcgc 1015321 cggaatggct gctggaggcg ccaaaaggca ccttggatga gtttcttgaa gctcttcagg 1015381 aacaagaagc ggaagaggaa cgtttcgttt ggcctcttag attggacgat gagacagaaa 1015441 acgaagcaaa cctaacaaac cttgatcctt tttttggcgg tttatttgaa gacattgatc 1015501 gcagcgatct gtcagacgtg ctggaagggc ttgagcggca tccagtgtat agaaggcacg 1015561 cggaccggtt tagccaagag gaggtaaagg aaataaaaga gcaggcacag ataatattga 1015621 aaagacagct taaggtgctt gatacatgag gcggtgacag ctttgcgaat tatatcttta 1015681 catatctacc aatacggaaa attttccaat cggacctttg acttttccgc ctctcctgtc 1015741 caagtcatct acggattaaa tgaggcagga aaaacgacga tgatgtcatt cattgaaagc 1015801 atgctgttcg gttttccgaa aacgaaaaag tatgaaccga aaacaggcgg tgtctacggc 1015861 ggtgttcttg aagctgaaca tcctgagtat ggggtgctga agatcgaacg gacgaaaggg 1015921 actgccgaaa aactaagcgt gtacacagaa aagggcgaag taaagcaggg agatgtttta 1015981 aagcagctgt tccagggcac agacaggtcg ttgtacaaag ccatatattc gttcgacgta 1016041 ttcgggctgc aggaaattca cgcctttaat cgggacaaga taggggaatt tttgctcttt 1016101 tccagcttgt ttggtgctga agccgtatca aagcttgatt caaggctgac gaaggaaagc 1016161 gaaaggctct ataaaccaaa tgggcgaaac cctcaattga atcaggagct ggaaacgctt 1016221 aagcagctgg cagttaagct aaaacaggct gaagcagagg aagcgggcta tcatcagctt 1016281 ctcgaggaaa aacgaacgct tgaagcccgc cttgcagccg cggaaaccga attgaaagag 1016341 acggcgggac atatccgaat gattgaggga gcgattgagc gaaagccgct gctaaatgaa 1016401 aaagcgacac tcgaacaggt gattgcagaa tttccggaac acgcaggaca atttcctgct 1016461 gacggactgc atcagctgga aaaatatgaa tcccatcttc acccgaaatc agcacagctt 1016521 gaggcgcttc gggtgaagat ggcggagttg gacaaacaga ggcaaaagct tatccccgat 1016581 aaagaactat tggcgaaaga aacgctgata caagagcttt cggcagcgtt tcatatgtac 1016641 caatcctggg gagaacagct ggcagccatt caggcacagc tgcgccagac gtctgcgcag 1016701 acagcggcag ggctggaaca gctcaataaa acggatgaaa atgagctcct gaatatgaac 1016761 acctcatatg attatgaatg gcagcttcag caagcggtgc agcaatatgt acaggcaaga 1016821 gacagaaaac ggcagcttga cgagacgttt gaacttgccc ggcaagagct ggaagacgcg 1016881 gaaaaggccg ttcgtgccgc ttcgtccgcg attcttgaaa acagccaaag aaaagataaa 1016941 gaagcagctc ttagagcata tgatgaaaca caggggcagc accaagagca agcgaagctc 1017001 agagaacagc taacgttttt tgaaagacag caggctaaac agaaaaagac tgtcattgca 1017061 gctggtatgt tgttcatcgt tctcttttct ctgctgcagc aatggattcc cgccataagt 1017121 ttcggcgctg cacttattgt gtattggctt gtttcaggaa agtcgtcttc tcgaaacagc 1017181 cgagagacaa gacagcccat gacggatatt tcaccagcag aagctgaaat gcttagagaa 1017241 gcgttatggg aggatgaccg caataagcag caccttctca cacagcgtgc agcgctccag 1017301 caaaaagagg cggcgtatga aagggtcatc cagcagtttg aacagtggga agccgaaatg 1017361 gcgccgtcct ttacacaggt tgagcgtttt atgaatgagc tcggatttaa ggaagatcca 1017421 tcatttttgc ttgatgcata cagcttaatg aaggatgtta aaaaagaagt gaagaaaaag 1017481 catgagctga ccatagaagc aggcaggctg aaaaagcacc ggagaacatt cgaagaacgc 1017541 gtcagtatgc ttcttcccgt gaatcagagt caggatatct ccatttcgga cgcccttcac 1017601 acattgcgga aaaacattga acgtgaaaaa gaaattgaga agcaaaaaaa ggaaattgaa 1017661 acagatattc attatacaaa ggaacagatg cttgaacttg agcaagaaat acagtatttc 1017721 cacgcacaga ttgaacagtt atttgccgcg gctgctgcaa aagacagaga tgcgtttttt 1017781 gccatagccg ccatcagcag gcaattgaag gatacggaga acaagcttca tcacgtaaac 1017841 gcacagcttc aaggcgggta cccggaggaa cttgaactgg cggattccaa tacgctttct 1017901 gaattgaaag ataagcaatt tgttgagaat gaaagaaaag agcggctgac tgaggagatc 1017961 gagcagctcc gcagccaaat cgcactgctc tcagtcaaac aggaacaatt agaggcttcg 1018021 ggaatggtct cagacctcaa gcttcaaacc gaaatgcaaa aagaacgtgt gaaagaaacg 1018081 gctaaaaaat gggcctccat acaaatggtc aaacaggtga tcagaaacaa attggagcgg 1018141 cataaaaaaa tcgagcttcc gcgccttctg gagacggcag gagaattttt ccgtcctctg 1018201 actgacggaa actaccaaac catttatttt tccgaaacgg atgattcgat catggttatg 1018261 catcgcgatg gcactgtcta tcatgcggaa gagctgtcac aagggacgtg tgaacagctg 1018321 tatacagcga tccgctttgc tttggccgtt acgcgccagg gtgagtcaaa gcttccgttc 1018381 cagcttgacg acagttttgt tcattttgat caggaaaggc tgaaacgtgt attacatgtt 1018441 ctgtatgatt tatctgaagg cggtaggcag attttgtatt ttacatgcca tgagcacgta 1018501 aaagatgcat ttcatagcag ccaaatcatc catttggtgt cataaaagag gttctatagc 1018561 tgaaaatcgg tatgtgatat actggtatta tgtaagatac ggagggagct ttaatagaat 1018621 ggctaaaggg attatgctac atgaggttgg cgaacaggtg gaccagtatc tattgattaa 1018681 atcctcgacg aaagggattg caagcaatgg aaaaccgttt ctgacgctga tgctgcaaga 1018741 ccagtcaggc gatattgaag cgaagctgtg ggatgccaag caaagtgatg aagtgaccta 1018801 tgcgccgcag acgattgtca aggtcgtcgg cgatgttcac cattatcgcg gacgcaccca 1018861 gctgaagcta agaaatatca gaccggtaag cgagcaagaa aacgtcaata ttgatgattt 1018921 tttagaaacc gcgccgattc cgaaaaatga aatgatggat accatcactc aatatatatt 1018981 tgaaatgaaa aatccgaata tccagcgaat cacaaggttt ttggttaaaa aacacgaagc 1019041 tgagtttatg gattatccgg cggctacgaa aaaccaccat gagtttgtct caggtttggc 1019101 gtatcatgtt gtctctatgc tgaacctggc gaaagcaata gcagatttat atccttctct 1019161 tgatcgtgat ctgctttacg ccggtgttat cctgcatgat cttggaaaag tgaaggagct 1019221 gtccggccct gtttccactt catatacggt tgaaggcaat ttgctcggcc atatttccat 1019281 catggtgaca gagctttcaa aagcggctga ggagcttcaa atcgattctg aagaggtgtt 1019341 aattcttcag catttgattt tgagtcacca cggcaaagca gaatggggca gcccgaaacc 1019401 gcctatggtg aaagaagcgg aaattcttca ctatatagac aatctggatg caaaaatgaa 1019461 tatgatggac agagcgcttg agcgcgtgaa gccgggcgag tatactgaac gtgtatttgc 1019521 actggaaaac cgttcctttt ataaaccgac atttcataaa taacttaaaa aggactgatg 1019581 ctgacatatt cagctcagtc ctttttgatg cgtctttccc gcacataact cgtctcattc 1019641 ccgcatatgg ttaagaataa agaatctatg caaaggggga ggagcccgtg ttattttttc 1019701 cgtggtgggt gtatctttgt attgtaggca tcattttcag cgcatataaa cttgtggcgg 1019761 cagccaaaga ggaagaaaaa gtagaccagg cttttattga aaaagaagga cagatttata 1019821 tggagaggat ggaaaaggag cgagaacgcc gcagttctca gcagcatgaa gaagaaaatc 1019881 aaaaccattc catcgcataa aaaaagctgt gcggctcaat gagccgcaca gcttttttta 1019941 ttatttagaa ttgcttgaag atgaagaagt gctgttgctt gttgaagatg tattaaatgt 1020001 gtctttcaga tctttatctt ttacttcgat gtcagccttc ttcatgactt tttgaacagc 1020061 ttcctgaaca gctgcgttgt catttaattt ttgttcaagc acttcagatt tcagttcttt 1020121 tttcatatca tcatatttgc cgcgttcttc tgtcttttta atgatatggt agccgtattg 1020181 cgttttgaca ggatcactga cttcacctgt ttttaatttg aatgcagctt tgctgaatgt 1020241 ttcgtccatt tggccttctt ttgcgaacca gccaagatcc ccgccttttg aagcagagct 1020301 gtctgttgag tattctttcg caaggtcttc aaacttctcg ccttttttca gctttttctc 1020361 tacttcttca gctgtctttt tatcagcaac aaggatgtgg cttgcacgga ttttgccttt 1020421 taagccttcc cagtactctt tgatatcggc gtctgttact ttgatgttat ctttagccgc 1020481 tttttgtgtc agcaattcat attttacttg ttctttcagg taatctttgc catattgctt 1020541 ttcgagggca gtatattgat cgccaagctg cgttttgtat tctttcagct tgttgtcaat 1020601 ttctttatcc gaaactttat acttcttgtc caatactttt tcttgcacta gctgtgtcag 1020661 tacgcttgcg ccagctgttt tcttcatgtt tgtgtaaagc tcgccttttg tgacatcgcc 1020721 tgcgtctgtt tttgcgataa cttctttgtc gccgctgctg caagcactga gagcgaggat 1020781 gcttgtagca gtgatagctg ctattgcgat tttcttcatt gttttcaaac actcctaatc 1020841 attccaaatt aaattaccta tgcgtatcat aacatattgt ggctttctgt aaaaagattt 1020901 taaataaagg gcattcgtct agtcaaactt ttgctgatga catacttata tattgatcaa 1020961 gaaaaggagg tatgtaacat gagcggagga tactctaacg gattcgcgtt gctcgtagta 1021021 ctgttcattt tgcttatcat cgtaggtgca gcttacatct actaagcagc ccgaggatcg 1021081 cttgcaacat aagcgatcct ttattttcac tagcgcctaa tcgtttcaaa catgaattgc 1021141 ataacatgta attggtaaat aaagcttatt acaggaggtg ctatttaaga tgggtgaagt 1021201 atttgcaggc ggattcgctt tattggttgt gttatttatt ttattgatta tcatcggcgc 1021261 ttcttggctg tactaatcaa cataaaaaag catagctgct taatcagcag ctatgctttc 1021321 tttcgtattt acactgtaaa ggagatctcc acaaacgaag agatcagtaa aattaatata 1021381 gatacattaa taaatcggaa taccttatct tgccgctctt caggaatctc tctgacaagg 1021441 cataatgtat tggtgagcct gtttatgaaa tataaaataa acacggcagc cacgataaaa 1021501 tagaataaaa tgatgggaga ttccccctct ctctgaactg tcccatatta cattaccaaa 1021561 tatttattaa aaaagataga atgcaaattg aaaaatcgcc accagcacca gggtttgact 1021621 acttttcaac aagaatatcc aagccgtcag cttcctgatc aataaaagcg gttttcggtg 1021681 cttttatcag cttgagagcc agcaggaaat caggcagaca gtagccggcg tgaatgcccg 1021741 agatcatgca aaaataatga gcgtgattcg gaaatgccag tgctgcgtaa aacaataccg 1021801 gtgtaatcag caagaacggg ctgacgagtg aaatcagcat tgttgttttt ggtatacgtt 1021861 tccatgtgcg catgcgcaat atgtaaaact ttttttctat ttttcttttt ttgcagatga 1021921 ttggcaggac atggatgact ttatgtacaa ataaaataac gacgagcaaa ccgccgaata 1021981 aagatacata ttcatcgctt aagcttgtgc caggccgcag cagctcaaaa gctaaaaagg 1022041 tagatataaa aaccaaaatc ataaaacata cagcagttaa tattatgcga acggcgccat 1022101 aatccttcat gagatttatg gtcttccagc aattcatcaa agtcatcctt ccatacatct 1022161 tgaatagaat ctcaaaataa tttactcctc ccaagagaaa aaatcaatgc ttttttaaga 1022221 aaaaatatca tccggcaggt atttttttga aacaagcaaa caaactgcga aatatggggt 1022281 tagaactttc ttctcagtga attatcagct aaaataagat taaagataga aagaagtggt 1022341 gtggatggat tcgatggatc atcgcattga gcgattagaa tattacatac aattattagt 1022401 gaaaacagta gatatggaca ggtacccctt ctatgcgctt ctcattgata aagggctgag 1022461 caaggaagaa ggggaagcgg ttatgaggat atgcgacgaa ttgtcggaag agctggcaac 1022521 acaaaaagcg caaggatttg taacctttga taagctcctt gcgctttttg ccggacagct 1022581 gaatgaaaaa ttagatgttc atgaaacaat ttttgccctg tatgagcagg ggctttatca 1022641 agagctgatg gaagtcttta tcgacatcat gaagcatttt gattaactgt ttacaggttc 1022701 gagctcttca gccggttcat ccgccgcact gtcctttgct tttttcttca attttccgtt 1022761 tacgctttca aagtcattgt caatattggt gagtgacgtt tcgaaaattt ccataaaatc 1022821 atcgccgtag atatggcgta tcatacacat catttctgcc acttcaggaa attttccgaa 1022881 taaatgatat aaaggctgtg accctttaaa aacagcgttg cgtgtcggat caaattcctc 1022941 aagcaagctc cagaatacct cggtaccttc ctcagtcaat tggacatatg tgttccgttt 1023001 atcattcagc cgtttggaga accttaaata tccccgttct tccagctttt ttgaaaagtt 1023061 gaatgcggtt gatacgtgca tgaccccgaa tttcgcgatt tcagaaatgg aagctccatt 1023121 caattgatac gcaatccata aaatatgatg ctcattaata ttcaggtcat acggtttgag 1023181 ccattgctgc caatccttct cgatcgattt ccaaagagcc ttgctaagct gagccatttt 1023241 ctgggtgaaa accagagctt ctttcacatc atagggcggt tccactcgat tcattacgtc 1023301 acctgcttct ctttttcttt ttctctatta tgccaataaa ataaagatta ataaagatga 1023361 aaatgtaaga attttttaat aaattcacaa accattgcga cgaaagggtt tttcggccaa 1023421 aaaaaatacg ggtccaattt tggcccgcat ttttttcttt tgaataggat attagttttg 1023481 taaggttttc tccagctgtc tgattttctc ttcgatatcg gcaatttctt tttgcagatc 1023541 ctgctggtga ggcttgatct cttcctgcca ttttttaatt gatgtttgga gctcgccgcc 1023601 cacgtcttta ataacatccg tgctttcttt tgccgctttg atcagctggt cttttaatgc 1023661 aagcccgtct gactttaagc gtttgattgt ttcttcaaaa gaatcataat tggttttcat 1023721 tttttcacgc agctgctttc ctgaggaagg tgcagtaaga agaaccgctg ctcctccgat 1023781 gatgccgcct acgaatagtc ctgttaatag agaacgtccg ctcgccatta caatcacccc 1023841 gtctttttct tcaaaatagg attcattcag catttttcat ttttgttgaa agcctgaact 1023901 tctatacata gcttgcttta ttttagcata ttttttaagt gaaaaggagg gagaaggttg 1023961 tctgtctttt tgattgtatt atcctgcatc acccttgcct tcgcttcagg cgctgtttac 1024021 tatatcaaac ttctcagcca ggctgcttct tatccgccca agagggttat ccggcagaaa 1024081 gcgcttgttt gttcaaccgg aaccgccttt acactatgtc ttatcttttt cacaaaactc 1024141 ctcgcttaaa acatgctgac atgctgcggg cgctctgttc aaaaaaacct ctcccggaag 1024201 cggaagaggt tttgtgtgac aattatttag cagcttccat aaagcttgaa cgccttaaaa 1024261 tggtttgcac aatcggataa ataatgatca ttgagattgt attcagcaca gcggccggca 1024321 gaacaacagc cgcgaacaat gcggcgaaac cgcccggtaa accgacgatc aataaagctg 1024381 acgatagaaa cacaattcct gataagatgg tcccgatcac tgtcagcaca gcggctgcac 1024441 ctgttttccg gctctttctg aacaagagaa acagggagaa gaacagaaac gctgatacgg 1024501 gtttatcaat gatgttaggg atctgtccgg ctggaaacgc ggttgtaagc gcggaaatga 1024561 ttccggtcac gatcccgatg acgagtacat tttgcacccg cgggaacagc agaatgccca 1024621 tgaacatcat gatcagcatc atatctggtt tcatgccgcc taaaaagggc ggaataatgg 1024681 aatgaagcgc tgcgccgatt gcggcaaaca gagccataat gactaactct tttgttttca 1024741 taactatgct ctcctctgct aagctttttg ccctccaata atatgctcat catttattgc 1024801 gaaggcttta cagaatgtgt tatgcaaaca gtataccaaa cggacggttt gcatagccag 1024861 actttttact cattttcctg ctggaatttc ttcatgaacg cagctaattt ttcacagtct 1024921 tcgagagaga ccgcgttata aatagaagcg cggcagcctc ccaccgaacg gtgtccgcca 1024981 aggccgatca tcttcgcatc ttttgctttc tgaacgaatg ttttcgttaa ttcgtcatcc 1025041 cgaagcgtga atgtgacatt catgcgtgag cggctgtctt ttctggcatg tcctttatag 1025101 aagccgttgc tttcatcaat acagctgtag agaacctgcg ctttttgttc attgcgctgt 1025161 tcaacagctt ccacaccgcc gttttccttg agccattcca gaacgaggct cagcatataa 1025221 atcgcaaatg tcggcggagt gttgtagagt gaatccgctt tgacatgcgt ggaatatttc 1025281 aagatttttg ggacgttcgc attttcattt tgcagccagc tttttttcat gatgactaca 1025341 gtcacgccgg aagggccgag gttcttttgg gcgcctccgt agatcacatc aaatttggac 1025401 acatcgattt ttctgcttaa aatatcgctg gacatgtcgg ctacgagcgg aattggagaa 1025461 ttcggaaact cctgccactg agtgccgaaa attgtattgt tggatgtgat atgtaaatat 1025521 gcgccgtctt ttacatccgt aaggtcaacc tctggaatat aactgtaatt gtctgtttca 1025581 cttgtagcgg tgatagacgt gttcccgaac agtttcgttt ctgccagtgc tttttcagac 1025641 caagcgccgg tcatcacaaa atgtgcggtt ttttcaggtg ttaaaaagtt catcggaagc 1025701 attgagaatt gaaggcttgc cccgccttga agaaacaaga tatcgtaatc ttccggaatg 1025761 cccatcagtt cgattaagag gcttttcgct ttttggtgca ccgcttcata ctctttgctg 1025821 cggtgggaaa gctccataac agacatgccg gattcgttaa aatcaataaa ttctttctgt 1025881 gctttttgca gaacttccag tggcagcgct gcaggacctg cgttaaaatt cgttgtacgt 1025941 tccattatga tctctccctg ttttccacgt taatgtataa aataatacaa ttatcctatc 1026001 acaaaaattc agttttttga taaaaaatta gaattatcaa aagaaattga cggatgtttg 1026061 cgaaatgttc acaaaataaa ataacctcat cttatgatga ggccaggcgt tttgcgatag 1026121 aggaagagat gttctgcaga tcctccggtt tataatcatc agcatgcgtt ttccaaaccg 1026181 ctccgaatcc atctcctttt ccgtagcgag ggataatatg catatggtag tggaacacag 1026241 attgtccagc tttttcgccg ttattgttca gcgtatttaa gccgatcggt tcaaattcat 1026301 cccggatagc gcgggcgatt tttggaacag catggaaata ttgttttgct aattcatctg 1026361 taaattcata tacattctca atatgtgttt tcggaatgac aagcgtatgg ccttttgtca 1026421 cttggctgat atcaagaaag gcaagtacat gttcatcttc atacaccttc gctgatggaa 1026481 tgtcgccggc aataatttta caaaagatac aattctctgc acaatgcatg agggttcctc 1026541 cttatgaaat tgtttagtat gtatacattc atcgtaccac agaaatgcag aaaatagaaa 1026601 acaggatgaa cggcgagcgt tcaccctgaa tgcagaggaa gagcttatat gaagaaaatg 1026661 tgttatgcct ttggtaagca cctcatttgt caataaaatg aagacttgtt taatgcctaa 1026721 cgattcctgc gataaacacc tcatttgaca atttgcttca tacatgaaga attcatcaat 1026781 tcagtgaaga gaaatggttt gagcattgga catgtttatt ttctatccaa ctgtttctaa 1026841 gacgtctttg acaaacacct catttttcag ttgatatgct tttcctctac aacttttatg 1026901 atgtccagaa ccctgtctct ttatgacagc aaattcatca tttgttaaaa gggaattgtt 1026961 tcaaatcagg ccttgttttt ggtactatga agaaaaacac tataagggga gaaactatgt 1027021 ctctgctatc ggtaaaagac ttgaccggcg gatatacaag gaatccggtt ttaaaaaacg 1027081 tatcattcac ccttgaaccg aatcaaattg tcggcttaat cgggctgaat ggtgctggta 1027141 aaagtacaac aatcagacac atcatcgggc tgatggaccc gcataaaggt tcaatcgaat 1027201 taaacggtaa aacgtttgct gaggatccgg aaggctaccg ttcacaattt acctatatac 1027261 ctgaaacacc tgttttatac gaagaattga cgctgatgga gcatcttgaa ctaacagcca 1027321 tggcatatgg actgtcaaaa gaaacgatgg agaaaaggct gcctccgcta ctaaaggaat 1027381 tccgaatgga aaagaggctg aagtggttcc cggcccattt ttctaaagga atgaagcaga 1027441 aggttatgat tatgtgcgca tttttggcag agcctgcgct ctacattatt gatgagcctt 1027501 ttctagggct tgatccgctt gccattaacg cgctgcttga acggatgaat gaagcgaaaa 1027561 aaggcggggc gagcgtgctg atgtcaacac acattttggc aacggcagaa cgctattgcg 1027621 attcgtttat tattttacat aacggcgagg tgcgggcgcg cggcacgctg tcagagctca 1027681 gagagcagtt tggaatgaag gacgcggcgc tggacgattt gtatcttgag cttacaaagg 1027741 aagacgctgg ccatgaataa tatgcttgat atttggcagt cgcggctgca ggagcatatc 1027801 aaagaaacaa gaacatacat gaaatatatg ctcaacgatc acctcgtcat tgttttgatt 1027861 ttttttctag cgggcgctgc aagctggtac agcaaatgga tacgggacat tcccgctcac 1027921 tttccgtcct tttgggtgat ggccgtgctg ttttcgctcg tattgacaag ctcttatgtg 1027981 cgaacgcttt tgaaggaggc tgaccttgtt ttcttattgc ctcttgaagc aaaaatggag 1028041 ccttacttga agcaggcgtt tgtctacagc tatgtgtctc agctgtttcc gctgattgcg 1028101 ctgagcatcg ttgcgatgcc gctttatttc gcagtcactc cgggagcttc gctcgtatcg 1028161 tatgccgcgg tctttgtcca actgttgctg ctgaaagcgt ggaatcaggt aatggaatgg 1028221 cgaacgactt tccaaaacga ccgcagcatg aaacggatgg acgtcatcat tcgctttgcg 1028281 gcgaatacac tcgttcttta ttttgttttc caatctgttt atatgtatgc gcttctcgtc 1028341 tatgtcatta tggctgttct ttatctgtat atgtcttccg cagcaaaacg gaaaacattt 1028401 aaatgggaga gccatattga gtccgaattg agacgaaagc agcgtttcta tcggattgcc 1028461 aacctgttta ctgatgtgcc gcatttgcga aagcaagcca aacgcagagc ttatctcgac 1028521 tttttgctgc ggcttgtgcc gtttgaacag cgcaaaacat ttgcctatat gttcacccgc 1028581 gcctttttgc gttcgagcga ttatttgggc attcttgtca gattaacgat cgttttcgcg 1028641 ctgatcatta tgtatgtctc agccagcccg ctgattgccg cggttttgac tgtgtttgcc 1028701 attttcatta cgggcattca gcttctgccg ctcttcggtc actttgacca tctggcgctt 1028761 caagagctgt accctgtgca aaaagaaaca aagctgaaaa gctatttctc tctattaaaa 1028821 actgcactta gtattcaagc gctgctgatg tctgttgcat ctgcctatgc agccggcttg 1028881 accggttttc tgtacgcgct gatcggttct gccgttctga tttttgttgt tttgcctgct 1028941 tatatgacga ccaggctgaa aaagcacgga aagctgtgaa ctgaaaagag gtaatcaaat 1029001 gacagataat cagctgctga tgcaggaagc tttggaatgg aaaatgcatt ttttgcgaaa 1029061 ggattccatg tttgaacgct tttcgaagcg tgtccagacg aaggtgaatg aacggattcc 1029121 tgaaaaaatc catacggtcg tcaccgagag tgtgaaaaaa atggtagaag cgacaatggc 1029181 cggctctaat atcatcacct ataaaaagga tacaagtgca ctgtcgctca gtgaaaaaaa 1029241 cgaattggcg aaaaaaacga ttgtttctta tcaaaaagtg gcagctgctg agggagtcgg 1029301 caccggagcg ggcggcattt ttttaagcat tgctgatttt ccgctgctgc tttcaattaa 1029361 gatgaagtgt ttatttacct tgtcttccat ttacggcttt gatgtcaagg atgcacaaga 1029421 aaggatattt ttgctgctcg tgtttcagct tgcgttttcg agtgatgatg gccgtaagtc 1029481 gcttttttct gtcatcgaaa attgggagac ggagaaaaag agcatcgact ggagagtgtt 1029541 ccagcaggaa tatcgcgatt atatcgacgt cgtgaagctt tttcagcttt tgccgggcgt 1029601 aggagcggca gtcggcggaa ttgccaatta taagctgctt gctcagcttg gagaaacggc 1029661 aagacatgtt tttcatctga ggatattaaa ggaaacagcc ggagaataaa cactccggct 1029721 gtttttttat agctgatgat aggtgatcgc agcgccggca aggaccttgg ccgctgtcag 1029781 catggctttt tcgttgatat caaatttcgg atggtggtgg gaatagactc gctctggctg 1029841 ttcgggagcg gcgcctgtaa agaaaaaagt gcccttcacg ttttgtaagt aataagcaaa 1029901 atcctcgccg cccatttgtg gttcaccgtc aatgacctgc tgaacgccct cggtattctt 1029961 tgcggtgctc accaagtggt tcgtttctgc aggatggttc acaaccgctg gataaccctg 1030021 ttcataggtg tactcatagg acgcgccgtg catgctgcat attcctttta caaccgcttc 1030081 aatttctttc tccagaatgt cccggacatt ttcatcaaaa gaacgcgctg tgccgatgag 1030141 tactgcttgg tctgcgatga cattaaacgg attgtcggcg atgaaggagc ctgtcgaaat 1030201 gacggcggat tgaatcggat tgactttgcg gctgacaatg tgctgcaaag aggaaacgat 1030261 ttgcgaaccg attaggacgg cgtctttagt atcatgcgga tgagcgccgt ggccgccctt 1030321 tccgaagact ttaatcgtaa atcggtctgc cgccgccatt acggcgccgg ggcggcagag 1030381 aatagttccg agcggctcag ttgcccaaag atgagtgccg aatatcacat ccgtgttttc 1030441 gagacatccg tcatcaatca ttggctttgc gcctccagga taatattctt ctgcatgctg 1030501 gtggatcatc acaaatgttc ccttcagttc atgtctgttt tggtgaagga ccttggccac 1030561 tgcgagaaga gctgcggtgt ggccgtcgtg gccgcatgca tgcatgacac caggcacttt 1030621 ggaggcgtaa gggacatctt tttcatcttg aatggggaga gcgtcaaagt cggccctcaa 1030681 agcgactgta gggccgggtt cgcttccttc tatatttgct aaaacccctc taccgccaac 1030741 gtttgtgcgg attgggactc ctaacgattc ataataggaa gcaataaatg cggcggtttt 1030801 ttcttcttga aatgagagct caggatacat atgaaaatgg cgcctgatct caaccatttc 1030861 ttcaaaacag ccgtcgagct gtttgtttat ctctttctgc agtgtggata tggacaaagc 1030921 cgcttccccc ttttctatgc ttttccatga ttgtatagaa aaagtctgaa tatttcaact 1030981 catgctgttt taaagcatca tcacagctgc gagggttgtc accaaaaggc caatcgcgac 1031041 gggaatgaag ttttttctgg caagctcaaa aggatcaact ttgcaaatgg ccgcggcggg 1031101 aatcaaagcc catgggacca gtgttcctcc gcccacccag atggcagaga tttgtccgag 1031161 cgcggtcaga atagcgggat cggcatggag agcggacgaa aagagctttg cgatggagcc 1031221 ggcgagagaa atgccagaaa atcctgagcc gtcaaggcct gttatggctc cagcggcagt 1031281 taatgcagtg gcggcaagct cctttgacat aggcatcata tgggataaag caatgccaag 1031341 atcgttgaca atgccgtggg aacctttagg gagtgaagtg cccagtatgc tttcatagcc 1031401 tgagtcgcca agataaaaga aagcggcaat cgggatgacg gggccgaaaa ccttaaaacc 1031461 gaacttaaat ccgtcaataa aatagccggt gattttttca agccctttat gcttatacac 1031521 gaaaaaatga acggtaaaga ggatacaaat tgcagacccg ccaattaacg cggttgcatc 1031581 atttccttgt aggttaaaca agagcatgca ggcgatatct gcaagaaagg caagcggaat 1031641 caaaaaagcc agtatggacc gcaggcgttt tggcaagtac agcgagttgt cttgttcgcc 1031701 ggaaagaacg ggggaaaaag aagtgggatg ctcctgtttt ttgcgttcgc gctgaatcat 1031761 gataaaggca gcagttgttg ttgtcacacc cataatcagc acaagcggaa tactggccga 1031821 gacgacatca ccgactggaa tgcctgctgc atccgcagtc agctttggcg ccgcctgaat 1031881 gacaaagtct cctgacaggg caaaaccgtg tccgaataag ttcatggcca tggccgcggc 1031941 aagaggcgtc aaaccggcac gtgcggctgc ggggagcagg acggcgccga tcaaagcgac 1032001 acccggagaa ggccagaaga atagagaaat ggcgaacatc aggcctccaa tcagccaata 1032061 ggcagtcaca ggccctctca caaggcttgc aaagggagaa atcatcgctt catttatccc 1032121 tgtttttgtt aacaaatcac tcattgaaac gataaagcaa atgatgaaaa tcgtgggcag 1032181 cagttcgccg gccgcataga taaagctgtg gaataaactg ctgacagaag ctgaaagtga 1032241 atggctggcc catagcgata tgataaaaat gccgaataga gaaataaatg tcgtgtcttt 1032301 tctcagcagc ataaatagga taattgcacc gataaaaaac acatacagaa catggacagg 1032361 caaaatcccg acttccatca tcgatcactc cttccgctta cagattattc ataggcgggc 1032421 ggaaggtgcc gggacagagg ggagggttat gatggaagat gaacattgat ctgtttcagc 1032481 tgctcaatca gatgatgcct taatcctcta ttcgcttttt gcagatgttt tgggaagcat 1032541 tcaggagaaa aaatgacgca cccttcagca agccagtttt ttctataggc gatgatgctt 1032601 tccgatggct ctatatgagt tatcctcgtg ctgcatctcg tactcatcaa atccgaactg 1032661 aaaaccgcag cacgggcaga tttcatgaga atgattgcct tcatgatcat atggcggttc 1032721 agccaatcct taaacccgca gactgggcaa gtatgcttca ttttgctttc ctcccaataa 1032781 aataagctgc cggacatgcc ggcagctatt cgacagcgaa atatgtggtg acataggaag 1032841 gccgggagaa gatcgacgtt gtgtcaattc cggcagatgt atcgcgtttt ttgtgggctt 1032901 ctttgtaaga accggactgc tgccagtctt gaaaggcgct ttccgtttcc cacaaggtca 1032961 gaatgacata ggtgtcactg tcaagcggac ggagcactcg aattgcttca aagccaggct 1033021 cgttttcgac ttttcccgct ctgtttttaa atctgttttc aaacagcgga cgcccttcct 1033081 gagtaacggc aatattgttc aatactgcaa aaccgggatg tttgatctct ccgacttggt 1033141 caatgacttc ataagcgtgt ggtgcctgga aaacggtatc tccgtttgtt tcatgaatta 1033201 aaatggcgtt ttcctgcccc tgcatcaaaa ggatattttc tgagggatgc ttctgtacga 1033261 tcgtttttaa aaaatcggct gtcccatatg taatataaac cttcatatca gccacctcct 1033321 gcttgctagt atatcaaaac aatggtataa gtttctattg gcgagtgctt cgaacataat 1033381 tccaaacaat ttttcccata ctacctttag aaaggcgagg tgagttcatg tttaagataa 1033441 agaaaaagaa actttttata cctatcatta ttttagtgtt aactgctttt ctcgctttaa 1033501 taggatatat ttcaattatt tttctcggcc attatgtcat agatgaaaaa aagcttattc 1033561 ttcatgcttc ttcaaaaatt gttgatcaaa acggagatga ggttgcaagc ctgtatacag 1033621 aaaatcgcga gccggtctcg atcaatgaga ttcctaagca ggtcagagaa gcgtttatcg 1033681 ctgttgagga taaaaggttc tatgagcatc acggcattga tgcaaaatcc gtcggaaggg 1033741 cagtgtaccg cgatatatta gcaggcggaa aggtggaagg cggaagcacg atcacccagc 1033801 agcttgccaa aaatattttt ctgacacatg acaaaacatt tctaagaaaa acaaaagaag 1033861 tgatcattgc gattaatctt gaacgggatt acagcaagga caagctgctt gaaatgtatt 1033921 taaaccagct ttacttcgga cacggggttt acggcataca agcggcgtcc cactattatt 1033981 ttaataaaga agtaaaagat ttgactgtat ctgaaggcgc tgttttggcc gctattccga 1034041 aggcgccttc tacgtactct ccaattttgc accctgataa aaataaggag cggcgtgata 1034101 caattctagg tatgatgaat gaccaaggct atatcagtgc gaaagaggct gtcaccgcac 1034161 agggccggac gcttggactg catgtgaaga aacagtcgga aacaccttgg tttgacagct 1034221 acattgacct tgtgatcaaa gaggcggaag acaagtattc catttccgga gagcagcttc 1034281 ttcaaggcgg atacacgatc aaggtgccgc tcgattcgaa gctgcagaag acggcttacc 1034341 aggtgatgaa agagggaagc tattatcccg gaacagatca gaatgccgag ggaagcgcgg 1034401 tctttattaa taacaagaca ggcggtgtag aagcggccat cggcggaagg gattacacat 1034461 ccaaaggata taaccgtgtc acagctgtcc gccagccggg ttccacattt aagccgcttg 1034521 ctgtatacgg accggcgatg caggaaaaga aatttaagcc atattctcta ttgaaggatg 1034581 agttgcagtc ctacggagat tatacgccga aaaactacga cagccggtat gagggcgaag 1034641 tcactatgtc tgacgccatt acgtacagca aaaacgcgcc ggctgtctgg acgctgaatg 1034701 agatcggcgt cgaaacaggg aaatcttatt tgaaagcaaa cggcattgat atccctgatg 1034761 aaggccttgc tcttgctcta ggcggcttgg aaaaaggcgt ttcaccgctc cagcttgccg 1034821 gcgcgtttca tacatttgcc gcgaatggaa cgtatactga acccttcttt atctcgagca 1034881 taatagatga agacggagaa acaatagccg atcataaaga agaaggaaag cgggtattca 1034941 gcaagcagac gtcttggaat atgacgagaa tgctgcagca ggtagtcaaa aagggaacgg 1035001 ccacgtccgg cacctatcac ggcgacctgg cgggaaaaac aggttcaaca tcttatacag 1035061 gcgtctccgg cgcgacaaag gacgcctggt ttgcaggcta tacgccgaaa ataaccgggg 1035121 cagtctggat gggctatgac aaaacggatc aaaaccatta tttgaaagcc gggagctcat 1035181 acccgacgcg gctgtttaag gatattttga cacaggcagg agaaaccggt catgtgttca 1035241 caaagcctaa aaacgttaaa gaactggaaa gcccgattga gctgaagccg gtcaaaacac 1035301 tcacagccga ttacacattt aaagcagcgg ggctctttac tattgaatta aagtgggacg 1035361 ctcaagagga tgatcgggcc gtatacagaa tttatgtaaa caaggacggc gaggagacgc 1035421 ttcttgattc ggttgaaggg aagggaagct atgaaattcc ttatgccaac ttattttcgg 1035481 gcgcgtctta taaaattgtg ccttataata cacagacaaa aagagaaggg gaaggaaccg 1035541 attacgttca gccaaaattg ttttcctctt aatggaattc ggcgattttt tgaactttga 1035601 gctacatttc tataccattt gcctaaaaca aggtatagtg taataagtca agaaatacga 1035661 acgtatggtt gccgtatgaa aggtggaaat cagatgagta aacgagaaac gtttaacgag 1035721 acgtttttaa aagctgcgcg gggagaaaaa gcggatcaca cgcctgtgtg gtatatgagg 1035781 caagcagggc gctcacagcc ggaataccgc aagctgaagg aaaagtacgg attgtttgag 1035841 atcacacatc agcccgaact ttgtgcgtat gtcacaagac tgccggttga gcaatacgga 1035901 gtcgatgctg caatccttta taaagatatc atgacgccgc tgccgtcaat cggtgtggat 1035961 gttgaaatca aaaacgggat cggtcctgtg attgatcagc caatccggtc tctggcggac 1036021 attgaaaaac tcggccagat tgatccggaa caggacgtgc cgtacgtgct tgagacgatt 1036081 aaactgcttg tcaatgagca gctgaacgtc ccgctcatcg gtttctcagg tgcgcctttt 1036141 acgcttgcaa gctatatgat cgaaggcggc ccgtcgaaaa actacaataa aacaaaagcc 1036201 ttcatgtaca gcatgccaga tgcatggaat ctgctgatgt ccaagcttgc cgacatgatc 1036261 atcgtgtacg tgaaagcgca gattgaggca ggcgcaaaag cgattcaaat ctttgattcg 1036321 tgggtcggcg cattgaatca ggcagattac agaacataca tcaaacccgt gatgaaccgg 1036381 atcttttcag agctcgcaaa ggagaatgtg ccgctgatca tgtttggcgt tggcgcaagc 1036441 catcttgcag gtgattggca tgaccttcct ctcgatgttg tcgggcttga ctggagactc 1036501 ggcattgatg aagccagatc aaaaggaatt actaaaacag tgcagggcaa cctggacccg 1036561 tccattttgc ttgcgccatg ggaagtcatt gagcagaaaa cgaaggaaat acttgatcag 1036621 ggtatggagt cagacggctt cattttcaat cttggccatg gggtatttcc tgatgtcagt 1036681 cccgaggttt tgaaaaaact gacagcattt gtccatgaat attcacaaaa caaaaaaatg 1036741 ggtcaatatt cctaagcata tcttttggta tcttaatgat atcctgtcaa aatgtttgta 1036801 tcagatcatt aaagagggtg taaacagtga gtagaaagaa aatggggctt ctcgtgatgg 1036861 cgtacggcac gccttataag gaagaagata ttgaacgtta ttatacacat atcagaagag 1036921 gcagaaagcc tgaacctgaa atgcttcaag atttgaaaga cagatacgaa gcgattggcg 1036981 gcatttcacc gcttgcccaa atcacagaac agcaggcgca taatctggaa cagcacttga 1037041 atgaaattca ggatgagatt acgtttaaag cgtatatcgg actgaagcat atcgagccgt 1037101 ttattgaaga cgccgtagca gagatgcata aggatggcat tacagaagca gtcagcatcg 1037161 tgctggcgcc gcatttctcc acgttcagcg ttcagtccta caacaaacgc gccaaagaag 1037221 aggctgaaaa actcggcggc ttaacgatta cgtcagttga aagctggtac gatgaaccga 1037281 agttcgtgac atattgggtt gaccgagtga aggaaacata tgcgtcaatg cctgaggatg 1037341 aaagagaaaa cgcaatgctc atcgtatccg cacacagcct gccggaaaaa atcaaagaat 1037401 ttggagaccc gtacccggac cagcttcatg aatcggcgaa attaattgct gaaggcgcag 1037461 gcgtttccga atatgctgtc ggctggcaaa gtgaagggaa cacgcctgat ccttggctcg 1037521 gacccgatgt tcaggattta acacgtgatt tattcgaaca aaaaggctat caagcatttg 1037581 tatatgttcc tgttgggttt gtcgcggatc acttagaagt gctttatgat aatgattatg 1037641 aatgcaaagt ggttactgac gatatcggcg caagctatta ccggccggaa atgccaaatg 1037701 ccaagcctga atttattgat gctttggcaa cagtcgtatt aaaaaaatta ggacgttaaa 1037761 gaaggcgatg aacatgagtg acggcaaaaa acatgtagtc atcatcggcg gcggcattac 1037821 cggtttagcc gccgccttct atatggaaaa agaaatcaaa gaaaagaatc tgccgcttga 1037881 gctgacactt gttgaggcaa gtccgagagt cggcgggaaa atccagactg tcaagaaaga 1037941 cggctatatc atcgaaagag ggccagactc atttctggaa cgaaagaaaa gcgccccgca 1038001 gcttgttaaa gacttaggtc ttgagcattt gcttgtcaac aatgcgaccg ggcaatccta 1038061 tgtgcttgta aaccgcaccc tgcatccaat gccgaagggc gctgtaatgg ggataccgac 1038121 aaaaattgcg ccgtttgttt ctacgggtct gttttccttg tccgggaagg cgagagctgc 1038181 tatggatttc atcctgcctg caagcaaaac aaaggatgat cagtcattgg gagaattctt 1038241 ccgcagacgt gtcggagatg aagtggtcga gaacttaatc gagccgctac tatcagggat 1038301 ctacgcaggc gacattgaca agctcagcct gatgtcgaca tttccgcaat tttatcagac 1038361 ggaacaaaag catagaagcc tgattctcgg catgaaaaaa acaaggcctc aaggctcagg 1038421 ccagcagctg acggcaaaaa aacaagggca gttccaaact ctgtcaaccg gtttgcagac 1038481 ccttgtagaa gagatcgaaa agcagttaaa gctgacgaag gtgtataaag gcacaaaagt 1038541 gaccaaactt agccatagcg gctcttgcta ttcgctcgaa ctggataacg gcgtcacact 1038601 tgatgctgat tcagtaattg tgactgctcc gcataaagcg gctgcgggaa tgctttctga 1038661 gcttcctgcc atttctcatt tgaaaaatat gcactccaca tccgtggcaa acgtcgcttt 1038721 aggtttccct gaaggctccg tccaaatgga gcatgagggc acgggttttg tcatttcaag 1038781 aaacagtgac tttgcgatca cagcctgtac gtggacgaat aaaaaatggc cgcacgcagc 1038841 gccggaaggc aaaacgctgc ttcgggcata tgtcggaaaa gccggagacg aatccattgt 1038901 cgatctatca gataatgaca ttatcaacat tgtgttagaa gacttaaaga aagtcatgaa 1038961 cataaacggc gagccggaaa tgacatgtgt aacccgatgg catgaaagca tgccgcagta 1039021 ccatgtcggc cataagcagc gtatcaagga gctgcgtgaa gcacttgcat ctgcgtatcc 1039081 gggtgtttat atgacaggcg cttctttcga aggtgtcggc attcccgact gcattgatca 1039141 aggaaaagct gccgtgtctg acgcgcttac ctatttattc agctaaaacc tccgctttat 1039201 cgcggaggtt tttttgatgt gcaatggcaa tattgtgtaa aaaatgattg aattgaacag 1039261 caggttatga tacatttgca tatgtactta atgactaaaa tgttcaaacg gtcagtttcg 1039321 aggtgaatac aatgtcaata gatcgaaaaa agctcatttt ggaggcggct acaaagtctt 1039381 tcacgcagtt cgggtataaa gcgacgacaa tggatcttgt cgcaaaactt gcgaacgtgg 1039441 ggaagggaac catttatact tttttcaaaa acaaagaaga gctgtttgac gagattttca 1039501 ctactttatt aaaggaaatg aagcaaaaag cggatgaagc gatggagccg agccttccgt 1039561 tccatgaaaa tgtgcacaga gcgctgtttg ccattctgga gttcaggaaa acacatcagc 1039621 tgacgattaa aattttccaa gagaatgccg agattggtac aatggcagtt caggaagtga 1039681 tccagaaaat ggagcgatcc atcctgtctt atatcaaaag caagattgaa gacgggatca 1039741 aaagcggcgc aatcaagccg tgcgaccctg agctgacagc ctttgtgatg ctgaagcttt 1039801 atatcgcgct catttttgac tgggaaaaac aacacccccc gcttgataaa gagacaattg 1039861 cgggactgct tgaattgtat gttgtcaaag gattgtcagc gaactagata atcctttctc 1039921 tttgcaagaa aatgaccatt ttttatgatg agtcagtttt agaatggagg catcaggatg 1039981 aacacaatac gaagtcagtg gaaagacatc gtaacaagta aaaaattatt gattcccatc 1040041 atcgccattt tgtttgtccc gcttatttac agcggcgtat tcttaaaggc ttattgggac 1040101 ccgtacggca cagttgacca gctgcctgtc gttgtcgtca accaagacaa gggagcaacg 1040161 tatgaaggag aaaaacttca aatcggtgat gatctggtca aagaattaaa ggataataac 1040221 aactttgatt ggcatttttc caatgatctc gaccaatcgt taaaggactt attgaatcaa 1040281 aaatattatt tagttgtcga gattcctgag gatttttcta agaatgccag cactgtatta 1040341 gacaaaaatc cgaaaaaatt ggatctgaaa taccatacaa atgcaggttc taactatgta 1040401 ggggcaacga tcggcgaaaa agcgattgat aaactgaaag cctctgtttc aaaagaagtg 1040461 accgagcaat atacgaaagt tatttttgat aactttaaag atatcgcaaa aggtttgagc 1040521 gacgcgagca gcggcgcgaa aaaaattgat gacggcacaa aggatgcgaa aaacggaagc 1040581 gcccagctga aagaaaatct ggcgaagctg aaggaaagca ccgctaccat cagtgacaaa 1040641 acagcgcagc ttgcagatgg agcggctcag gtgacgagcg gcatccaatc acttgacagc 1040701 tcgctcggta aattccagga cagcagcaac cagatttatg ataaatctag tcagcttgca 1040761 gcaggatcag gcgagctgac aagcaagatg aatgaacttc ttgccggact tcaaaatgtg 1040821 cagaagggta cgcctaatct tactaacggg ttggatcagc tcaacagtaa agtccaagaa 1040881 ggttctgaga aagcggcaaa agcggaaaag atcattaatg cgctcgattt aacgaagctt 1040941 gaaactgctg taaacaatct ggaaaagtca gaaactgcga tgaaggaatt caaaaaacag 1041001 ctgactgact ttgaaaacag tttgaaaaac cgtgatcagg catttaaaaa tgtcatcaat 1041061 tcgagtgact tcttaacagc ggagcaaaaa agccagctga ttaattctgt tgagaaaaag 1041121 cttccgcaag ttgatgcgcc tgattttgat caaatattaa gccagctacc tacagctgat 1041181 cagctgcctg acatcgcaac gataaaaagc tctcttgaag acgtgaaagc gcaggtggcg 1041241 caggtgaaag ccatgccgga agctacatct aagctttata acggcgcaaa aacaatccaa 1041301 gatgcgattg acagattaac tgagggagct gataagatat acaacggttc tcagaagctg 1041361 acagatggcc aaactaaact gacagcgggc atcggtgaat ataataagca gttcgcaaaa 1041421 gcaaaagcgg gctcagagca attggtgaca ggaagcagcc aagtatccgg cggattgttt 1041481 aagctgttag acgggtctaa acaggtccaa agcggatcat caaaacttgc agacggatct 1041541 gcatcacttg atacaggttt aggcaagcta ttggacggca caggagagct gtctagtaag 1041601 ctgaaggatg cggctgacca aacaggagat atcgatgctg atgatcaaac atacggcatg 1041661 tttgcggatc cggttaaaac caaagatgat gccattcatt ccgttcctaa ctatggaaca 1041721 gggctgacac cttatatcct gtcaatgggc ttgtatgtcg gcggcatcat gctgacggtt 1041781 gtcttcccgc tgaaggaagc gtcaggacgt ccgagaaacg gttttgagtg gttcttcagc 1041841 aaattcaatg tcatgatgct tgtaggaatc attcaatcat tgattgtggc gacggttctt 1041901 ctattgggaa ttggtcttga ggtagagagc acgtggagat tttacgtgtt tacgatcatt 1041961 acgagtctcg ctttcctggc gataattcaa tttttggcta caacgatggg caacccgggg 1042021 cgatttatcg cagtcattat tttagtgctg cagctgggag cgagcggagg aaccttcccg 1042081 ctggaattgc ttccgaattt ctatcaggtc atccacggcg cattgccgat gacctacagc 1042141 attaacggat tcagagcagt catttcaaac ggtgactttg gctacatgtg gcagatggcc 1042201 ggcgtcttaa tcggcattgc cctcgtcatg attgcactaa gcattactta ctttacaatg 1042261 ttaagccgga aggaagaaac atcagaagaa cagccggctt cataaagaaa aagaacttgt 1042321 ttccttggaa acaagttctt tttttgttac atcccccatt taataagcaa tcctgtatag 1042381 gttaatccgc cgccaaaccc gaaaagcaaa acgatttgat cttttttcag cttcccggct 1042441 ttcactgcga gatcgagcgc caaaacaatt gaaaccgaag acgtgtttcc gtagtgctca 1042501 acactagtga gcgttttttc aatcgggaac ggtgtttttt cacaaattga ctcgatcatg 1042561 cgcaagttgg cgctgtgagg aacaaaccaa tcgagatcat cggagctgag tcctgcttta 1042621 tgtaaaagcc gttcaaattc gccagggacg gttcttgcgg cccatttata tacctcgcgt 1042681 ccgttttgca ccatttttcc ggaaccgaca agctgcacac cgtttatttc atttcgcagt 1042741 ccggcacgat acaaaatatc gccgccgttc ccgcttgttc cttgtacaga cgcaagaaat 1042801 cccggcgtct cttcatctcg ttctactaac agcgcacccg cggcatcgcc gaacagtacg 1042861 catgtcgttc gatcggtata atcggttacc tttgataacg tctctccggc gatgacgaga 1042921 attttttgat gaaggccaga tgtgatcaat ccatttgcca aatggaggcc gtatgtcagc 1042981 ccggcgcatg tcgcattaat atccagcgcg ccggtgcttt cccagccgaa atattcctgt 1043041 acgcggcatg ccgtactcgg aaaggcgtaa tcggatgtgg ttgtggcaac gaggatcata 1043101 tcgacatcat caagcgttcc tttataacgg ctcttgagat tcttcaccgc ttctatgcat 1043161 aaatcagagg taaattgatg ttcatccgca atccggcgtt ctctcattcc tgtgcgctga 1043221 acgatccatt catcagaggt atcaacgatc ttttctaaat ctgcattggt taaacgtctg 1043281 ctcggcgcat aggtgccgat agctgtaatt tttgcttttg acatatgaat cactccttat 1043341 ggtcagatta taacactaga tattagtatc tggtactaaa aagaaggttt ttttacaaaa 1043401 aaagagaagt gtagatagga atctatgaaa aagaaaaagg aggctgaaaa atggtcagtc 1043461 aagaagcagt agtctttttg gcattatccg gggctattgc gtttctgttg ccaatcgggc 1043521 tgattgtatg gtttaagcga aagtatggtg cctcgcttaa agtgtttttt attggcgctc 1043581 tcacgttttt tgtcttcgct cagctgctgg aaggcggcgt tcatgtttat gtactgcaag 1043641 tgaatgaaat gacgaaagaa gcgatgcagc atccattatg gtatggcatt tacggctgct 1043701 tgatggccgg catttttgag gagtgcggaa ggtatttgat gatgcgattt tttatgaagc 1043761 gccatcatac ttgggcagat ggtctggctt tcggggcagg ccatggcggg cttgaagcca 1043821 tcctgattac aggcttgtcc tctatctcac ttattgtata cgcatttgca atcaatagcg 1043881 ggacgtttga acagcttttg gtcaatggcg acgtcaaaca ggcgcttttg ccgatacagg 1043941 agcagctgct gcatactcct tcgtatgaat ggatgctggg cggaatagaa agaatcagtg 1044001 ccattgccgt ccagattggt ctgtctctgc ttgttttgta cgcggttaaa aaccgccggc 1044061 cgctgttttt gctgtattct attcttttac atgcactgtt taatgtcccg gcggttttat 1044121 atcaaagagg aatcatagag catgctgcag ctgttgaaat cattgttgct cttatagcgg 1044181 ctttatcagt ttattggatt gtaaaagcaa aaagggtgtt tcaataaaag gtccaagcag 1044241 cagcaatgcc cgcttggaaa aatgtgaatg gaaatattca ttaagcatgg gtcatcagaa 1044301 tatttctgat tcagtcttta gcaatgacag caagaatgtc tgtgtttttt acaagagaaa 1044361 caatggtgtt tctttttctt cttctcgcaa gggtcatggc attctttctt tttcttgcaa 1044421 tggtcgtgga aatctttatc gaaccactcg tcaaagaacc aaaaatcatc gaaccaatcg 1044481 tgacaacgac atttctgttc atgtgaatga cgacagcaca tagaaatccc tcctcttccc 1044541 atgctctcta cagcatatga gagattgata ggaaaagatt ggacgggtcc ctcgggaaaa 1044601 gagtatattt taagtagaaa ataaaaggag gaatgcccta tgacgtccgt acgtaaaacg 1044661 atggagctca ttaaagaact tgtatcgatc ccaagcccga caggaaatac atatgaggtg 1044721 atcaattata ttgaaagcct tttaaaagaa tggaaggtag aaacggttcg gaaccacaag 1044781 ggcggcttaa ttgcaacgct tccaggacgc gacacatccc ggcatcgcat gctgacagcg 1044841 cacgttgaca ccctcggcgc tatggtgaag gaaattaaag cggacggccg gctgaaaatc 1044901 gacttaatcg gcgggttccg ctacaactcg attgaggggg agtattgcca aattgaaacc 1044961 gcctcgggaa aaatgtacac aggcacaatc ttaatgcatc aaacgtctgt gcacgtatac 1045021 aaagacgcgg gaaaggctga gcggaatcaa gagaatatgg agatccgcct agatgaacct 1045081 gttcactgcc ggaaagatac ggaggagctt ggcattggcg tcggagactt tgtgtcgttt 1045141 gatccacgtg tcgagatcac atcaagcgga tttattaaat cgcgccattt ggatgacaaa 1045201 gcaagcgtcg ccttattgct ccgcttaatt catgaaattc aaacagaaga cattgagctg 1045261 ccgtatacaa cccattttct tatttccaat aatgaagaaa tcggttacgg cgggaattcg 1045321 aatattcctc ctgaaacagt tgaatatttg gcggttgata tgggcgctat cggtgacggg 1045381 caggcgacgg atgaatattc agtatcaatc tgtgtgaagg atgcgagcgg gccgtatcat 1045441 tatcagctca gaaagcattt agttcaatta gccgagaagc atcatattga ctataagctt 1045501 gatatatatc cgtactacgg gtctgatgcg tcagcagcga tcaaatccgg gcatgatatt 1045561 gtgcatggcc tcatagggcc gggaattgac gcttcccatg catttgaacg cacccataaa 1045621 tcatctcttc gccataccgc taagcttctg tattactatg tacagtcacc aatggtataa 1045681 gggggaggac caatgaagat ttataagctg aaaagcacat tcggttggga aggtgatgac 1045741 gggttgggag aacagctgat tcagcagatc cttgccggag aaaaaagcgc cacgtgcgcg 1045801 ccgaaatcat tgtattcaaa agatgaattg agggacgttt atcaaacagc gggtcagctt 1045861 gttaccgttt atgataaaca tgacaatcca agatgcaata taaaagtaac agatgtcttt 1045921 gaaaccacct ttggtgcgcc tgatatgagg ttagtcaaag gagagggcaa tggagaccga 1045981 attgaggagt ttcaagagga tcatcggatg gcatgggcgg aactgatcaa aagcggtgaa 1046041 ctggagctga atgaggatac tgttttgatt acagagttgt ttgtgcttgt taaagattaa 1046101 aaaagcctgc ggggcaagaa ccccgcaggc ttttcattaa ccagaaatgg ttgcgttttg 1046161 ttctgttttc gattgggaca taacagtttc tgctttcgca ggattaaaca tgccttccca 1046221 tttagacatc acaacggcag caagcgcgtt accagtcagg ttgacaactg tacgtgccat 1046281 atccatgatg cggtctacgc cggcaataaa ggcaagtcct tcagccggaa cgccgatggt 1046341 gccaagcgtt gcaagcaaga caacaaaaga agtaccaggt acggcagcca tccctttgga 1046401 tgtcaccatt aagacgagca caagcgtaat ttggtgccaa atcgtcaaat caatgccata 1046461 tacctgtgct aaaaagagtg cggcaataga ttgatagaga acggaaccgt ctaagttaaa 1046521 cgtgtaaccg atcggaatga caaatgaaac aatgcctttt ggacatccga ttttctccat 1046581 tttttccatg atacgcggaa gaaccgtttc agagctggac gtactgaacg ccagtaagat 1046641 ttcgtccttc atgtaagcaa ggaacttgaa gatgctgatg ccggcaattt ttgcgacaat 1046701 cccgaaaata acaattaaga agaaagcaag cgcgacataa accaatccga cgagctttcc 1046761 gagagagata agagaaccga gtccgaattt agacacagtc actccgataa gagcgaaaac 1046821 gccgaatggc gccactttca tcacaaggtt tacaacgtgg aacatggcat gggatacacc 1046881 ttcaaaaaag gctaatacag gcttgcctct ttcaccgatc gcggaaatac ccaatgcaaa 1046941 tagtactgta aagcagatga tggctagaag atccccttcg accaatgact ggaagaagtt 1047001 tgtcggcaca atatggagga acgtttccgc cactgattta ttactttgtt ctttttcagt 1047061 ttcaacatat tgactgatgt ccgatttttg agcttcgtgt atattaactc ctgtacccgg 1047121 atggaagatg tttgcaaggg ctagtccgag aataatggca aaagtcgtga tgatctcgaa 1047181 gtacagaatc gttctgaagc ctaatttacc gacttgcttt ccatttcctg caccggctac 1047241 accgatgatt aagctggaga caacaatagg aatcactatc attttgatta agcgtaaaaa 1047301 gagatccccg attggctgca ggtaagtagg caatgctggg ttgccatacc aaatgacgcc 1047361 aacaatgaca cctagaataa gtccaacgaa tatttgtgtg gctaatccaa acttaattct 1047421 tttcatagat tacctcccaa aaaacaaagt atcaacatat atcatgaata gacatatatt 1047481 taatctcact attagatcaa attataatag ataagaaatc aattcgtcta tagtaaatta 1047541 tatttcgaaa ataaagaata ttcaatgaca ttatgataat caccagaatt atctaaaaac 1047601 aggtgagctt tgacctaacc tgactattat ttcaaaatta agagatatgt gaaaaaataa 1047661 gaaaatccca cgcgtaaggc gcgggatttt cgctcattac aaatcgttta cttttataca 1047721 gtcattgcag atattaccat aacactcatg ctgctcttct atcttttttc cgcattccgc 1047781 acactttttc gaaggcaggt ttctaaaaaa ttctgtgatt ttccccagca taaccaatcc 1047841 ctctttcccc tttgtagtga tttcattgta atataacaga ttacaaaaat caataactgt 1047901 tttgatacaa tgtttaaaac atgctttttt caagaaaaat gggtatattg aaggaggacc 1047961 aatttttttg aaaagatagg aggacattat gaaagttaca gttatcggat gctatggcgg 1048021 ttttccggcc gcaaatgaag cgacgtcagg ctatttgttt cagtcaggtg attactctct 1048081 gcttgttgat tgcggcagtg ccgtattgtc taagctgttc ggatatgtgc cggcggaaaa 1048141 gctggatgcg gtcgttctgt ctcattatca ccatgaccat atcgctgata tcggaccgct 1048201 gcaatttgcc aagcaagtcg gttcgtttct cggcaaagga gagcatacgc ttccgattta 1048261 cggacatgat gctgatatag aacagtttca aaagcttaca tataaaacac atacaaaagg 1048321 gatcgcctat cagccggatc agccgctgac tgccggtccg tttacgatca cctttttaaa 1048381 aacgattcac ccggtgacgt gctatgccat gcggattact gacggcagcc acactgtcgt 1048441 ttatactgct gattccagct atcaggattc atttataccg ttttcgaaag atgctgattt 1048501 attgatctca gaatgcaatt tttatgccga tcaagacgga acaagtgcag gccatatgaa 1048561 cagcctggaa gctgggcgca ttgcaaaaga agccggagcg ggagaactgc tgctgacaca 1048621 tttgccgcat tttggcgtgc atgacaacct tcgcaaagaa gcgaaaaccg tttttaacgg 1048681 agaagtgaat attgcgaaat caggttttgt gtgggaagga taaaggagga gcaccatgtt 1048741 atttatagac aatcaaaata tcaatgatcc gcggatcaat cttgctatcg aggagtactg 1048801 tgtaaagcat ttagaccctg aacagcaata tttgctcttt tatgtgaatc aaccgtctat 1048861 tatcattggg aaaaaccaaa atacaataga agaaatcaat acaaaatatg ttgaggaaaa 1048921 cgggattatc gtcgtccgcc gtttatcagg cgggggcgct gtgtaccatg atctggggaa 1048981 cttgaacttc agctttatta ccaaggatga cggggacagc tttcataact ttaaaaaatt 1049041 cactgagcca gtgattcagg cgttacatca gcttggggtt gaagccgaat taagcggccg 1049101 gaacgacatt gtagtagatg gccggaaaat atccggaaac gctcagtttg caacgaaagg 1049161 ccgtattttc agccacggca ccctcatgtt tgattcagcc attgatcatg ttgtatcagc 1049221 attaaaggtg aaaaaggata aaattgaatc aaaaggcatc aaatcgatca gaagccgagt 1049281 ggcaaacatc agtgagtttc tcgatgataa aatgaccacc gaagaattcc gcagccattt 1049341 gcttcgccat atttttaaca caaacgacgt tggaaacgtg ccggagtata agctgacgga 1049401 aaaagattgg gagaccattc atcaaatttc gaaagagcgc tatcagaatt gggattggaa 1049461 ctacggccgc tcaccaaaat ttaaccttaa tcattcgaag cgttatccgg ttggatcgat 1049521 cgatttgcac ctggaagtca agaaaggcaa aatcgaggac tgcaaaatct tcggagattt 1049581 cttcggtgtc ggtgatgtat ctgaaattga aaacctgctg gtcggaaaac aatacgaacg 1049641 cagcgtcatc gctgatgtgc tcgaaggtgt gaatctcaag cattactttg ggaacattac 1049701 gaaagaggat ttccttgatc tgatttacta aggcaaaaca catcgtttga aagagcggtt 1049761 gtgtttttga aataatggag gcaggaggga ttcacatgaa agtgttttta atcggagcga 1049821 acggacaaat cgggcaaaga ctcgtctctt tattccaaga taatcctgat cattccatca 1049881 gagcgatggt cagaaaagaa gaacagaaag cgtctcttga agctgccggt gcagaagctg 1049941 tgcttgcgaa tctggagggc agcccggaag aaatcgccgc tgcggcaaaa ggttgtgacg 1050001 cgatcatttt cacagccggt tccggcggca gcacaggcta tgataaaacg ctgctggtgg 1050061 atcttgatgg agcggcaaaa gccattgaag ctgcggccat tgccggaatc aaacggttta 1050121 ttatggtcag cgccctgcaa gcccataacc gtgaaaattg gaatgaggca ctcaagcctt 1050181 attatgtggc caagcattat gctgataaaa ttctggaagc gagcggttta acctatacga 1050241 ttatccgtcc gggaggcctt cgcaatgagc ctggaacggg aactgtttca gcagcgaagg 1050301 atctggagcg gggatttatt tcccgtgatg acgttgcaaa aacggtcatt gcctctttag 1050361 atgagaagaa tacggaaaat cgggcctttg atctgacaga aggagatacg ccgattgccg 1050421 aagcattgaa gaaactatga cagtactgac actcagggct ttttgctctt gagtgttttt 1050481 ttctgtttct ctataatgga gaagaaagct tggcttcaat aatgaatgac tattcattca 1050541 cttaaggggt gggagaatga atcttgtttc aaaattggaa gaaacagcat ctgagaagcc 1050601 cgacagcatc gcatgcaggt ttaaagatca catgatgacg tatcaagagc tgaatgaata 1050661 tattcagcga tttgcggacg gccttcagga agccggtatg gagaaagggg accatttagc 1050721 tttgctgctt ggcaattcgc ctgattttat catcgcgttt tttggcgctt taaaagctgg 1050781 gatcgtagtt gttcccatca atccgttgta cacgccgaca gaaattggtt atatgctgac 1050841 aaatggcgat gtaaaggcaa tcgtgggcgt tagccagctt ttgccgcttt atgagagcat 1050901 gcatgaatcg ctgccaaagg ttgagctcgt cattttatgc cagacggggg aggccgagcc 1050961 ggaagctgcg gacccagagg tcaggatgaa aatgacaacg tttgcaaaaa tattgcggcc 1051021 gacatctgcc gctaaacaaa accaagaacc tgtacctgat gataccgcgg ttattttata 1051081 tacgtcagga acgactggaa aaccgaaagg cgcgatgctg acacatcaga atttgtacag 1051141 caatgccaac gatgtcgcag gctatttggg aatggatgag agggacaatg tggtctgcgc 1051201 tcttcccatg tttcacgtgt tttgtttaac cgtctgtatg aatgcaccgc tgatgagcgg 1051261 cgcaactgta ttgattgagc ctcaattcag tccggcatct gtttttaagc ttgttaagca 1051321 gcagcaggcg accatttttg ccggtgtgcc tacaatgtat aactacttgt ttcagcatga 1051381 aaacggaaag aaagatgatt tttcttcgat ccggctgtgc atttcgggag gcgcgtccat 1051441 gccagtcgcg ttgctgacgg cgtttgaaga aaaattcggt gttaccattt tggaaggcta 1051501 cgggctctcg gaagcatcac ccgtcacgtg ctttaacccg tttgacaggg gcagaaagcc 1051561 gggctccatc gggacaagta tcttacatgt cgaaaacaag gtcgtagatc cgctcggacg 1051621 cgagctgccc gctcaccagg tcggcgaatt gatcgtgaaa ggccccaatg tgatgaaggg 1051681 ctattataaa atgccgatgg aaacagagca tgcattaaaa gacgggtggc tttatacggg 1051741 ggacttggca agacgggatg aggacggcta tttttacatt gttgaccgga aaaaagacat 1051801 gatcattgta ggaggataca atgtgtatcc gcgggaggtg gaggaggtgc tgtacagcca 1051861 tccggacgtc aaggaggcgg ttgtcatcgg cgtgccggac ccccaaagcg gggaagcggt 1051921 aaagggatat gtggtgccga aacgctctgg ggtaacagag gaggacatca tgcagcactg 1051981 cgaaaagcat ctggcaaaat acaagcggcc tgccgccatt acgtttcttg acgatattcc 1052041 gaaaaatgcg acggggaaaa tgctcagacg ggcactgaga gatattttgc cccaataaaa 1052101 tgaaaaagcg aagcggttag cttcgctttt tcattttcaa tcctttgctt cttttttaat 1052161 aatatttagc agcgcctttg tatcattttt gcttaatttg tagtatgtgc catccttcaa 1052221 aaaaacggct tgctggctgc cgtcaatcca tagtctgaat gagtcatacc ggtctttatg 1052281 aaacttgatt gtcccttcgt aatcaggggc tgatgttttt tctgtcttca cctgttttcc 1052341 ctgattcata atatccagca tatctttgac gtgctgtctt ttttcaatct cgatatcttc 1052401 ctggccgctt gaagacagtg tgatcaaatc cgcgtctacc gattgataca catcgcctga 1052461 tcggctgtaa agataaaaaa atgcgataaa cacaagaccg attaccacga tggctgccac 1052521 tatttttttc atttgcatca ctccaaacat tgttagtttt cccagcgatc ggggtttcca 1052581 tgcttaaaag ggtggaaaag tgcggaacac agcttggttc taagaatttg aatttatgat 1052641 tacaatagaa gtaacgggtt gatgtgagga gtgaggcgtt atgcgcaagt ggattgcggc 1052701 agcaggactt gcttacgtgc tgtacgggct gtttttttat tggtattttt tcctgtcggg 1052761 tgattccgca ataccggaag ccgtgaaagg gacgcaggct gatccggctt ctttcatgaa 1052821 gccgtctgag ttggcagtgg ccgagcagta ttcgaatgtc aagaattttt tattttttat 1052881 cggggtacca cttgattggt ttctgttttt tgttctgctt gtcagcggtg tttcaaagaa 1052941 aatcaagaaa tggatcgaag cggccgtgcc ttttcggttt ttgcagaccg ttggttttgt 1053001 gtttgtgctt tcgctgatta caacattggt gacgctgcct ttagattgga taggctatca 1053061 agtatcgctt gactataaca tttccacaca gacaacggcc agctgggcta aggatcaggt 1053121 tatcagcttt tggatcagct ttccaatctt tacgctttgc gttctcgttt tttattggct 1053181 gatcaaaagg catgaaaaaa aatggtggtt atacgcctgg ctgttaacag tgccgttttc 1053241 gctgtttctg ttttttattc agccggtcat tatcgatcct ttatacaatg atttttatcc 1053301 gctgaaaaac aaagagcttg aaagcaaaat tttagagctg gcagatgaag ccaatattcc 1053361 ggctgaccat gtatatgaag tgaacatgtc agaaaaaaca aatgcgctga atgcctatgt 1053421 tacaggaatt ggggccaata aacggattgt attgtgggat acgacgctga acaaacttga 1053481 cgattcagaa attctgttta ttatgggcca cgaaatgggc cattatgtca tgaagcacgt 1053541 ttacatcggt ctggctggct atttgctcgt gtcgctcgcc ggattttatg tcattgataa 1053601 gctttacaag cggacggttc gcctaacccg cagcatgttt catttagaag ggcggcatga 1053661 tcttgcggca cttccgctgt tattgctttt gttttctgtt ttgagctttg cggttacgcc 1053721 tttttctaat gctgtctcgc gttatcagga gaataaggct gaccagtatg ggatcgagtt 1053781 gacagagaac agagaagccg ctgttaaaac gtttcaggat ttggccgtga cggggctgag 1053841 ccaggttgat cctccggtgc ttgtgaagat tttcagaggc agccatccgt cgatcatgga 1053901 acggattcaa catgcggaga aagaagagaa tgcgccggaa catcaggatg ctgacaaata 1053961 aaaagaagca ggtatggagg aacctgcttc tttttactat tattgtgcag ctgcttgtac 1054021 gttgattaac ccttttccat agtagaaaga gtttccaaga tatgttgcag tgctttctaa 1054081 acgatcacgg acttgcgcgt ttgtccaagt cgggtgctta gaaagaatta acgctgctgc 1054141 tccggcaacg tgaggagtcg ccatggacgt tccgttataa gcgccgtaag tgcctccagg 1054201 aagtgtgctt tggatggaca cgccaggagc catcacatca agctcagaac ctgcgctgga 1054261 gaatgaagct ctttggttgc tgctgtttac cgcacctact gcaatagtag aaggatattt 1054321 tgcagggtag ccgactgtgc ttgtgcttcc ggatgaacct tcgtttccgg ctgcggcagc 1054381 aacgacgata ccgctggaaa cggctttgtc aacgactgtt ttcagcgctg tagaaccagt 1054441 aggtccgcca aggctcatgt tgataacatc catattgttg gaaatggccc actcaatgcc 1054501 gttaataatc cagctatatt ggccgcttcc tgttgaatca agcactttta ctgcatataa 1054561 tgatgcgctt ggcgctacgc ccagaacacc gattgagtta ttaagagcgg caatcgtacc 1054621 ggctacatgc gtaccgtgag aactgccgtc ctggtatggg tttgtttcag aaggtacgaa 1054681 gcttgctccg cctctgacgt ttaagtcagg atgagaagag tcaattccgc tgtcgataac 1054741 agctactttt acgttagagc ctgtgtagcc ttgagagtga agagccggcg ctttaatttg 1054801 agaaatgcca taaggaacag attgcgcata ttcatgtgca atatgatctt cttccacata 1054861 tgcaacgctc ggatcttttt tcaattcttt tacagctttt tcatccaatg ttgctgcggc 1054921 cgcgttaaca tacttaaatt gcttttgaac ctttccgcct ttttcagaaa taacatcctt 1054981 tttcttggcg gaactcatgg cactcattgt ctgtttaaat ccgacaatgt atttcttttc 1055041 tgtactgctt tttccggcag cctgcgcaga catgttgctg aacgccatcg taaagattaa 1055101 cgttaacgca aacaacaagc tgatccacaa ttttttgctt ctcactcttt accctctcct 1055161 tttaaaaaaa ttcagagtag acttacttaa aagactattc tgtgaattta ttgtaataga 1055221 tggaataata ttttagtaga cccatttttt tgagatgatt ttatctctat ttaggtatat 1055281 catctctcgc tatttccgta gagactcgaa ataactattt tcatacagaa aagaacgaaa 1055341 atagacatga gtaaatgttc attatgctga aatgtcatgc ttttttaggt taaatgctcc 1055401 tgagtcccgg caaattcctg tcgaaaaaat tcgttcaaat gacctgcgtg tgcttccgtg 1055461 agaacaatgg atattatcgt gatatttttt caaagcatga tgataaaagt attctgaaaa 1055521 ataaacttta cagaaaaggg atagaatgaa aaaattattg agagggagga agaaataaga 1055581 tgaacattcg ccaagcaaag acatcagatg cggccgccat tgcgccgctg tttaaccaat 1055641 atcgggaatt ttatagacag gcatccgatt tgcaaggggc agaggctttt ttgaaagctc 1055701 gtttggaaaa tcacgagtct gttattttga tagcagaaga aaatggagaa ttcataggct 1055761 ttacccagct ctatccaacg ttttcttctg tgtcaatgaa aaggatatac atattaaatg 1055821 acttatttgt cgttcctcat gcgcgtacaa agggagccgg cggccggctg ctttctgccg 1055881 caaaggatta tgcagggcaa aacggggcaa aatgtttaac acttcagact gagcaccaca 1055941 accggaaggc aagaagcttg tatgagcaaa acggctatga agaggatacc ggatttgtcc 1056001 attattgtct caatgtgccg gcgaagtgaa aatggcggct tgatgatttg gttttttgaa 1056061 cgttcttcgg ttacgatata aatgaaaagg agtgtgccga atgtcaacgt tatttcaagc 1056121 cttgcaggca gaaaaaaatg ccgatgatgt ttcagtccat gtgaaaacca tatcaacaga 1056181 ggatttgccg aaggatggtg tcctgattaa agttgcttat tccggcatta attacaaaga 1056241 tggtctggcc ggaaaagcag gaggcaatat cgtcagagag tatccgctta ttttaggcat 1056301 tgatgctgcg ggtacggtcg tctcttccaa tgatccgcgt tttgcggagg gggatgaggt 1056361 gatcgcgaca agctatgagc tcggtgtctc acgtgatggc ggattaagtg aatacgcttc 1056421 ggtgcctggt gactggctgg tgcctttgcc acagaatctt tcgttaaaag aagcgatggt 1056481 gtacggaacg gcgggattta ctgcggcgtt atcagtgcat cggcttgaac agaacggtct 1056541 gtctccggaa aaaggcagcg tgctagtcac aggagcaacc ggcggtgtcg gcggaattgc 1056601 ggtatcgatg ctgaacaagc ggggttatga tgtggtggca agtaccggaa accgggaggc 1056661 ggctgattat ttgaaacagc ttggtgcaag cgaagtaatc agcagggaag atgtctatga 1056721 cggaacgctt aaggcgctgt ccaagcagca atggcaggga gcggttgatc cagtcggcgg 1056781 aaaacagctt gcctcgcttt taagcaaaat tcaatacggc ggatctgtcg cagtgagcgg 1056841 cttaaccggc ggaggagaag ttccggcaac cgtgtatcct tttattcttc gcggagtaag 1056901 cctgctcgga atcgattcag tatattgtcc gatggacgtc agagccgctg tttgggagcg 1056961 catgtcttct gatctcaagc ctgatcagct gctgaccatc gtggacaggg aagtatcatt 1057021 ggaagaaacg ccgggtgcgt taaaagatat tttgcaaaat cgcattcaag gaagagtgat 1057081 tgtgaagctt taacaggatc agcttgcaga gaatgttatt tttctgcaag cttttttgtg 1057141 gacaggatga tcagctgctg aactgctgtg tcgcgaaaca agattttcct gtaagccgaa 1057201 ctttctcttc tcattttaaa aataattggt gataatgatt ctcattccgt gttatactac 1057261 tcttggacat cttaaccata gaaactacca acaggagaga ctggaacata tgaaaaaaac 1057321 actgattatt cttacagttt tacttctttc tgtcttaacg gctgcttgct cgtcttcaag 1057381 cggcaatcaa aacagtaaag aacataaagt ggcggtaaca catgatttag ggaagacaaa 1057441 tgtgcctgag catccgaagc gggttgttgt tcttgagcta ggttttattg atacactgct 1057501 tgatctcggc attacgcctg tcggggttgc cgatgacaac aaagcgaagc agctgatcaa 1057561 caaggatgtg ctgaagaaaa ttgacggcta cacatctgtc ggcactcgct cacagccaag 1057621 catggaaaaa atcgcttcat taaaacccga tttaattatt gctgacacga cccggcataa 1057681 gaaggtgtac gatcagctga aaaaaatagc gccgacgatt gcacttaata atttaaatgc 1057741 tgattatcag gatacaattg acgcttcgct tacgattgca aaagcagtcg gcaaggagaa 1057801 ggaaatggag aaaaagctga cggcgcatga agaaaagctt agcgagacaa agcagaaaat 1057861 cagcgcgaac agccagtccg tgcttttgat cggaaataca aatgatacca ttatggccag 1057921 ggatgaaaac ttctttacat cgagactttt aacacaggtc ggctaccgat atgcaatcag 1057981 tacgtcaggc aatagcgatt caagcaatgg cggcgactct gtgaatatga aaatgacact 1058041 ggagcagctg ctgaaaacag atccggatgt gatcatcctg atgacaggaa aaacagatga 1058101 cctcgacgcc gacggtaaac gcccgatcga aaagaatgtc ctttggaaaa aactgaaggc 1058161 agtgaaaaac gggcatgtat accacgtgga tcgtgcggtg tggtctctgc gccgcagtgt 1058221 agacggggcg aatgccattt tggacgagct tcaaaaagag atgccggctg ctaagaaata 1058281 aaagaaaaga caggcaaacg cctgtctttt tcttatttga taaagccgga taagtggctg 1058341 ttgatattat agtcttttat ccgccatttt tcttctgcaa attcaatgtt gctgaggcag 1058401 gcgttgacga gacgggtgct ttgaagctcc gggtcaccgc cggatatttc tgtcagcagg 1058461 gcgtgaattg ccgcaccgtg cgccacgatc agcaccttct tgtttggata cgcctgattc 1058521 acttttgcca aaccgcccat cagcctgtca gtgagttctt ctaaggtttc catattcgga 1058581 tagatgttat ctggatagcg ctttgtccgt tcctccagcg gcatgccctc cgcgtcgccg 1058641 taatcgcgtt ccttaaaatc atccatctcg actatcggaa gatgcagata ttcattaata 1058701 atttccgcgg ttcttttcgc tcttttcagc gggctcgtca caataatatc ccaagaaaag 1058761 tcctttacat attctccggt ttctcttgct tggcgttcac ctgttgcgtt tagcgggata 1058821 tcggttttgc cttggcattt ttgctgcagg ttccaatcgg tttctccatg tcttactaaa 1058881 caaacggctg tcataaaatc cccttcctga ctttattcat atcgctatta tactaaatcg 1058941 aaagcgtgtg tcctatgaaa aagcctatgc aagaacttca aataataaag ccagtccgat 1059001 tccgccgccg cttccgatgg ctgcaacagc atattgacag tctggccgtc ttttcgcttc 1059061 ataaaacaat ctggttacca gagctgcacc tgatgcaccg tacggatggc caagagctaa 1059121 ggcgccgccg cgcacattga tttttgaaaa gggaatgccg agttcttgcg agcagacaca 1059181 aattttgacg gcaaaggctt cattgatttc aaataaatcg atatcatcag gtgttacatc 1059241 gtgtgtatgt aagagctgac gaatcgcgac aaccggtgcc gcgggcggaa agttggggtg 1059301 aatgccgctg acagcgctgc cgataaaccg aagcacaggc ttaagtccca gggctgctgc 1059361 tttttcttct tccattacca aaagagcggc tgctccgtct gctatgccac tgctgttggc 1059421 tgctgtgact gttccggagc tggtgtcgaa aaccggcttt gcacggggaa taatcgcttc 1059481 tattggccgc gttttcaaaa atgcttcgtc cgtctccaat tccccgagag caacaacttc 1059541 ttcacggtaa aatccttcat catgcgcgtt cctgctgcgt tgatggctga gaagcgcgta 1059601 ctcatcctgc atgcttctgc tgatggaata gcgtgcagcc gtatattctg ccgcaatgcc 1059661 catgtctgga tcgccgatcg catctggaga aaagcgagcc cgttctgaaa aaggggattg 1059721 gctgctgctt tctgagccgc ccgcgatata catcgtgccg gctcccgctt gaataaggct 1059781 gcaggcatag cgcacagctt caaggccgga gccgcactgt ctgtcaattg tcattccggg 1059841 aaccgataaa ggcagtccgg cttgaagggc tgacagtctg gccaggttgc cgcctctgcc 1059901 agtagcgttt ccgagaatga cctcgtcaac ttgatcctct agctttcggc tgagacagcg 1059961 gatgatggga gccgccaaat cctccggcag gaagggcttc agcagtccgt tttgatttcc 1060021 aaagatcgtt cgttttgcat caacaataac cgcattcatt tatactgtac actctcttcc 1060081 agccattttt tcactctgga acgggcaatt tttccgctgc tcgtttccgg caagctgtct 1060141 gcaaacaccc attttttcgg aattttatag gaggctaatt tctgtttaca ccaggctttc 1060201 agtgttctgg cattagcgtt tccaagaatg acagctacag cgatttctcc ccaatactcg 1060261 tcgggaatgc caacgacagc cgcgctttca acctctgggc aggcgagaag cacacgttca 1060321 atttcttctg ggaaaatatt taatcctccg tacacgatca tcccgttttc tcttcctgat 1060381 atgtatagaa agccctcttc atcaacgtag cccatatcat ctactgtcat ccattcatct 1060441 ggtgtgctgc cgttcacata gccggaaaac ctcatcgggc ttttgacaaa tatttttccg 1060501 atttctcctg gctggcagcg ttctcctcca gcgttgcgga tttcgatccg gacattatga 1060561 aaagggcggc ccgctgaatg cggcttccgt ttgctgtctt ccggtgaaga aaacgtcaca 1060621 aaactaagct ctgatgtgcc gtaaaaatcg tacagcttga gatgaggcca tgcagcggca 1060681 agcttcttct tggattctgc cggccagtct gcgccggatg aaatgatttt gacgggactg 1060741 tcgggaaaac cctcaatcct tgcgagggcg tctgtcatcg tcggtacggt atagagaaca 1060801 ctgatggatt cacggcacag ccattccttc gctttggcag gagaaaactt tttcagcaaa 1060861 caaacggttc ctccgagaaa caaagtgctg acagccccat ataggaagtg agaggacatt 1060921 aacgctccgg gaatcagaac cttatcatct gatgaaatcg aaaaatctgt ttctgtacag 1060981 gtaaagctct ccatccatga gcggtgagat cgcgtaaagg ccttcggttt tcctgtcgag 1061041 cccgacgtaa atcccatata aaaagggtgc tccggatcaa tggtaggcaa gggatcagcg 1061101 gctgcctcag aaatatctgc catacagtta tccagcaata caacaggtgt ctggctatct 1061161 gtcagtttgt ttttgaaaaa ggctaaagta accacaagat ccgcattgct tatggacagc 1061221 cgctccttac attcagccgg gctccagcgt gtgtcgatgg gaatggccgt acatccagcc 1061281 gctgcggctc cggcaaacag ctgtaaaaac gcgagactat ttgggagcag gatcgccaca 1061341 cgattcggca tgctcggctg tgaccgcagc caatttgcgg tttgagagac aagccgatcc 1061401 caatcatggt acgtgatttg ctccgattca gtctggatcg ctacacggcc gggcgatgtt 1061461 tcggcagtag atgaataggt atgagtaatt gtcatgtatt gtcatcctcc ttttgtaaac 1061521 atcgtatcag aaagagacaa ggcttgagtg atttttatcg ccagaaatgc agatacagcc 1061581 gcttttatca aatcaccagg cacatatgca aggctcatga aggcggcctg tgacaaatca 1061641 atatgcatga taaaagcttg taccggtata ccaagcagat aaataaagat gatgccgaat 1061701 acgatatgag tgaaaaagag acgcaatact gtcaccttcc gcagcctgtt agcggctaaa 1061761 ctgatcagcc atgaagcgag gggataagca atcaaaaagc ctgcgctcgg tccgaaaaac 1061821 acaccaaaac cgcctcgtcc gccgggcaac agcggcgctc cgaaggcgac gagcagcaaa 1061881 aagacaagct ggcttaagaa agcagacttt ggcctgagaa tgctgcctgc caacatgaca 1061941 ccaagcgttt gcaatgtaat cggaacgggt gtaaaggata agaagagagg gggcataaag 1062001 ccgagcactg ccatcagcgc ggtgaaaatc gcaatatgca tcatgtcgat taatttcagc 1062061 atgtgaaatc ctccaaaaag taatcaaata tggttataca ataaatgcag gtaattatta 1062121 tgtcaactga tttttaattt aagtttacat aatgaacgca aaaaaaccgg ccgtatggca 1062181 gaccggtttt tgatggttat tcttctgtca ggatgacaag cgaatcaacg gaagcggcca 1062241 catgggaaac ggcgcggctg acttcctgaa gccctccaag aaaggcttgc agatcgacgt 1062301 cgattttgcc tgattgctct ttgctgattt tcatgctgtg gacgatttca tcgaataagc 1062361 ggttaatttg cgtcattttt tctttacttt cgctgactag ctcattcacg tctttgatat 1062421 gcttggatac aatgttgatt tgtgtattcg tattgttcac aagctcagaa acagtagaga 1062481 cggttttttt cgtatcctca gaaagcttcc gcacttcatt tgccacgaca gcaaagcctt 1062541 tgccgtgttc tccggcgcgg gcggattcaa tagatgcatt gagcgagaga aggtttgttt 1062601 gttcagctat gcctgtgacg atgccgaaga ttttttcaat ttgctgcgcg atttcatcca 1062661 gcttgaccat ttctttttcg atttggacaa ggcttgtgtc aattttgttc atctgttttt 1062721 gctggacttc tagctctttt tttccgccga tcgacttttc ttcaacagtg ctggatgtta 1062781 cagtgccggc tttggatgct tgagaaatgc cttcagattt gtccacaagc tcttgaactg 1062841 atctgcttgt ttctgaaaac agattggcaa tcgatccaga ggtttcttga attttctgat 1062901 gaagaaggtt tttcttttct tcttgttcat cacgggtctg gttgtactcg ctttgaaacg 1062961 cttcaaggac aagctgctgt tctaagttca agatttttgt tgttgcttta atggctttta 1063021 gcagttcttg ctgatttgta atggacgctt cataaatgtc aatcattgac aaaaggagct 1063081 cttgaaacgc acccatatac cattttggca aaaggccgat tcttaaatgg atggaggcga 1063141 ttcggttacg cttttcaata aattcatcat cgataacgcc tgcaaacatt tcctgaatat 1063201 gccgttttaa cgtttgtttt aagcggtcaa ctgagctgtg atcattaatg atatccatca 1063261 atgagctttc atggtcaagg tttttataaa acgcatcgac gatatttacg atattttctt 1063321 gaatgagtgg ctgaagctgc tctaacacat aaagctcagc atctcccaac ctgaccattt 1063381 tgagctgttt tttgacatct gcatgtttgt ttgtgagctg aatgcggttt ttttgttgtc 1063441 cgtttgaatc tgaaaagtaa gctgtttctt gttttctgtc ttttttaaat aacaatacaa 1063501 tgatccccct tgggaaaaat ataattttta ctttttggct ttttaagcct ttttcttttt 1063561 tatcggccaa gggaaacatg aatgaagctg cagatgaaaa atatttgaaa aaacgttcat 1063621 taaaatgaac ggtttaatcg agatctattt gttttaatgg tttaatggcc ggaccctcta 1063681 caacttcgcc agatggctta aagcgtgatc cgtggcacgg acaatcccac gtatgctcac 1063741 tgtcgttcca ctcgacctcg cagcctaaat gggtacaagt cgtatcaacg agatggaggc 1063801 agcctgtctc atcacgaaat gctcccgctc gcctgccgtt tatggtgacg gctttccctt 1063861 ctcctggcga aatgtcttca aattggacat caggcttttc aagctttcct tttatcaaat 1063921 gcttggcgac atctgcattg taggaaatca ctttctgcaa cccgggattc agatggaaac 1063981 gggacggcgt gaaaatgctt tcgtatgggt tttctttttt ctccacaagg tctgacaata 1064041 aagtggctgc gactgctgag gacgtcatgc cccatttttt gaacccggtc gctactagaa 1064101 tattgtcctc attttccgac atcggcccga taaacgggat tttgtcgatc gtcactagat 1064161 cttgggtgga ccaataatat ggaatgcttt cgatgccgat ggtgctttcg gccagttgtc 1064221 tcagtgtttc ataatgtgta gacatggctt ttccctggcc tgttttatgg cttactccgc 1064281 tgaagagaat cagcttttca ccgtttacaa ccgtatagcg gagcgccact gacggctgat 1064341 cgatactcaa atacatgccc tcgggatact cgatcttcgg cttgatggca aggacataag 1064401 atctgtcgga gtacattctc gcagcatata atccgcctcc gtcataaaaa gggaagtggg 1064461 aacagcatat gataaagcgg ctcttaatgg cgtgccggct ttttgttacc acttcgggcc 1064521 tttcgccttt tttgatatca agcgcaacgg tctcttcata aattcggccg cctttttgaa 1064581 caatttgctc cagaagcgct tttaagtatt gaagcggatg aaattgagct tgattcttca 1064641 tgacaagcgc cagcttagaa cctaagggaa ttggaagatc cttgataagg tctctttcaa 1064701 ttccgagctt tgtgtatgcc tcatgctcgg tgtggatttt ttgaacagcg ttttcatttg 1064761 ccgtataaag atatgcgtct tgctcgatcc attcacaatc aatttgatgt tcatccacaa 1064821 tgccttttat gtaatcaatt gcgttttggt ttgcttcata ataaagcctc gcatggttta 1064881 atccgaaatg gcggataaat tcgtcgtata tcatgtcatg ctgtgcggta actttagcag 1064941 ttgtatgcgc agtggttccg ttaagaacct gatttgcttc aatcaaaacg acacggaagc 1065001 ctctcttcgt aagttcatat gccgttgtga ttcccgtaat cccgcctccg ataatggtga 1065061 cgtcacattc agtgtcctct tgaagcgcag gaaaagaagg caggtcagtt gatgttttcc 1065121 agtatgtttc aggtgcttcc tttgcaaaat gttgattagc caagccgtta tacctccaat 1065181 cagatttatt cttaattttt ccatattcta tcttttcata cataggaagc aggcattgtt 1065241 cataacataa taaggttgaa aaggagtgat ttcattggcg aatcaaaaaa agaaaacatt 1065301 accgcctcag caccagaacc agcagcctgg ttttgaatat ctgatggacc cgcgtccggt 1065361 ttttgataag ccgaagaaag cgaaaaaatt agagggcaaa accgctatta ttactggagg 1065421 agacagcggg attggacgcg ctgtctcggt gttattcgca aaagaagggg ctaatgtggt 1065481 cattgtgtat ttgaatgaac atcaggacgc cgaggaaaca aagcagtatg tagaaaagga 1065541 aggggtaaaa tgcctgctga ttgcaggaga tgtcggggat gaagcgtttt gcaatgatgt 1065601 ggtcgggcag gcaagccaag tgtttccatc cattgatata ttggttaaca atgcagctga 1065661 gcagcatgtc cagcccagca ttgaaaaaat caccagccac cagctgatca gaaccttcca 1065721 aacaaacatt ttttccatgt tttacttaac aaaggcagtg ctgcctcatt taaaaaaagg 1065781 gagctctatt attaataccg cttcaattac cgcctataaa ggcaataaaa cgctgatcga 1065841 ttattcagcg acaaaaggcg cgatcgttac gtttacaagg tccctttccc agtcgcttgt 1065901 tcagcagggc atacgggtca atgcagtggc accgggtccc atttggacac cgcttatccc 1065961 ggccagcttt gccgcaaaag acgtggaagt gtttggttca gacgtgccga tggaacgccc 1066021 ggggcagccg gtcgaagtgg cgccaagcta tctatacctt gccagcgacg attccacata 1066081 cgtcacaggg cagacgattc acgtcaatgg cggaacaatt gtgaacggat aataaaaagc 1066141 caatccttga aggattggct tattcgctct gcttgagcgc tgcatattct ttagagagcg 1066201 taagaaacgc atctttatct ttttcgtcca aggctttgtt aatttggtcc gtcagcatgg 1066261 caagccgacg gttatacaag gattcatcga gcaccatttg aatgtaaata tccgtcattg 1066321 tgacatcgaa ttcttttgtt ttttgcgtgt tgcgggactt catgagctca gtgtacgatt 1066381 ttttctcttt cataaagaat ccccccaatg ccttttttat agtatatgga taacggtcga 1066441 aaaaatcaat aaatttttat aatttttaga caactaatac ttggcaatct atcgacatat 1066501 cctgcaaaat gccgtaaacc ggcaagtctt atgaaagtaa aatcggttta ttactagtca 1066561 tttagtacca ttaaatatca ttaaaagatg attttatctt aaatgttaaa aaaacctgtc 1066621 gttttacaaa aacagatgat agattattag tataaatttt gcagaaaaag gatggaggcc 1066681 ataatatgag tcagaaaaca gacgcacctt tagaatcgta tgaagtgaac ggcgcaacaa 1066741 ttgccgtgct gccagaagaa atagacggca aaatctgttc caaaattatt gaaaaagatt 1066801 gcgtgtttta tgtaaacatg aagccgctgc aaattgtcga cagaagctgc cgattttttg 1066861 gatcaagcta tgcgggaaga aaagcaggaa cttatgaagt gacaaaaatt tcacacaagc 1066921 cgccgatcat ggtggaccct tcgaaccaaa tctttttatt ccctacactt tcttcgacaa 1066981 gaccccaatg cggctggatt tcccatgtgc atgtaaaaga attcaaagcg actgaattcg 1067041 acgatacgga agtgacgttt tccaatggga aaacgatgga gctgccgatc tcttataatt 1067101 cgttcgagaa ccaggtatac cgaacagcgt ggctcagaac caaattccaa gacagaatcg 1067161 accaccgcgt gccgaaaaga caggaattta tgctgtaccc gaaagaagag cggacgaaga 1067221 tgatttatga ttttattttg cgtgagctcg gggaacggta ttagaaaaat aggaaggagc 1067281 tgaccgaaca gggcagctcc tttcataaag ctatgccgtc ggaattcctc cggtgatgcc 1067341 atatacctga gatgtcacat agcttgaatt ctctgaagct agaaatacat aaacatcggc 1067401 caattccact ggctgcccag cgcgatttaa tggagctggc ggcgtgcctt gtccgaattt 1067461 cgggatgttt tccgtcggct gtccgccgga aatttgcagc ggtgtccaaa ttggtccggg 1067521 cgcaactgaa tttactctga tgcctttgga agcaagctgt tttcccagtc cgacggtaaa 1067581 gccgataatg gcgtttttcg ttgctgcgta atctaacagc atcgggcttg gattatagcc 1067641 ttcaactgag gtagttgtga taattgaagc tccctccggc aaatacggaa gcgccgcttt 1067701 tacaacccag taaagggaaa agacgttcac ttcaaatgtt ttatagattt gttcagtagg 1067761 cagatcttcg atgttttcga ccgcttgctg tttgcctgca acgagcgcta gcacatcaag 1067821 tccgccgagt tcgtgatgcg actgtttgac tagatcttgg caaaaggatt cgtcgctcaa 1067881 gtctccgggg atcagcactg cttttcggcc ttctgcttca atcagctctt ttacctcttc 1067941 agcatctggc tgttcctcgg gcaagtagtt aatagccaca tcggcacctt ctctggcgta 1068001 agcaattgcg gcagcgcggc cgataccgga atcgccgccc gtgacaagcg cttttcgacc 1068061 cgttagttta cctgatcctt tgtagctttt ttctccgcaa tcagggacag gcttcatgtt 1068121 cttttgcagg cctggcggtt cttgatattg ttcgggaaat tcatcatgaa aaaatgcttt 1068181 tataggattc gtaagatttg aatcagacat cagcaacgct ccttttctgt ttggtgtaca 1068241 ttcgtatgtg tacccctgag cataagcaga aaaacatgtt ttggcagttt gaatagtgaa 1068301 ggaaaaagaa aacaagaaaa aacaaagcct tcttccatat ttatcttgtc aaataagact 1068361 atatgaatta tgataaattc gagctataaa tcaactaaat attgggtgtt gggagagtga 1068421 atcgtcatga aaaaagcggc ggcggttttg ctgtcactcg gtctcgtttt cggtttttca 1068481 tacggagctg gccatgtggc ggaagccaaa acaaaggtga aggtctataa gaactgcaag 1068541 gagctaaaca aagtatacaa aggcggagtg gcccgcacat cgaaggtgaa aaacaaaggc 1068601 ggaaaaacga agtacaagcc ttacgtttct aaggcacttt acgatgccaa taaaaacaaa 1068661 gaccgcgata aagatcttat cgcctgtgaa cggtaaataa gaaaaagcaa tctggtgtcc 1068721 agattgcttt ttttatgctt aggccgcctg atcggccgca gcgcttttcg ccttccttgt 1068781 cataaggctg actgccatca tgaccgtgat attcaaaagc agggcgacga tgccgacatt 1068841 caagtctttt gcggcttgcg gcagagccgg aaataaagtg ccgatcgtcg tttccgtcat 1068901 tgtaatataa gtaactgctc cgacacctgc aataatgccg gcgaaagctc cttgctttgt 1068961 caccatatta tgcttgagca ggctgaacaa aagggcgggg aatagctgtg tgacaaggct 1069021 gtagcccatc aaaagcagcg taacgatggt attcccgcct ttgaaggtaa aatacaccga 1069081 aatcagcgca atcaccggca ctaaaaactt agcaagcgcc gatacttgct gttctgtcgt 1069141 gcggggcgcg attaccttgt acacattttt tgcaaacagt gtggaggcgg acattaagat 1069201 catagaccct ggcacaagtg ctgtcagcag tccggcagca ccgataattc cgacaaacca 1069261 agggtcaaat gcttgcagag acagtctcaa aagcgacaaa tccccgtctg cgccattcag 1069321 atctggaact tgcaggatag ccgcaaagcc gacgaaaagg acgaagagca ggaccagctg 1069381 gtacaaaggc atgatgatgg cgtttttacg aaacactttt gggttttcgg ctgaatacga 1069441 agcggaaaac gtgtgaggcc acatgtaaaa accaagcgct gtcaagagta cggttgaact 1069501 gaaccaggcc acactttgtc ccgattcggg gagcgtaaga aagccaggct ttgccgtttc 1069561 aatctgctga aacatgtctt gaaatccgcc gtagtaatga attggcaaat acacacctaa 1069621 aaacagaacg acaaccagaa tcatgatgtc cttcacaacc gatatccagg cagacccgtg 1069681 aatgcctgaa accataacat aaaccgtgat ggaaacagcg ccgatccaga tggcagcggt 1069741 cggggtgatt ttgccgtacg aggtttccga tacaatcagc ccgaggcctt tcagctgcag 1069801 tacaagatag ggaatgagtg cggcgatgcc gaccagtgaa acgagaatgc caagcagcgg 1069861 actgttgtat ttttttgtga aaaaatcaga ctgcgacatc agtttatgct gtttcgcgta 1069921 cgtccaaact gctggaagaa gccagtaaga aaggatgtag gccagacatc cgtaggcgat 1069981 gatataaaag gctggaccgc cttttccgta ggcccagccg ctgccgccga gaaacgtaaa 1070041 agtagtataa atttcgcctg ccatcaaaag gaagacgaaa acagttccga agccgcgccc 1070101 tccgaccgtc cactgctcca ggttcatgtc ttttcctttt tgggcgcgta taccgagaaa 1070161 aatactcaag agcaggacac cgaagatgat gatgagagct gcattcattc tgcttcctcc 1070221 tttttatttt ccttgtcgag gacatacaca atcgccatca gcgcagaggt caaaagagcc 1070281 cacatcacaa tataggcaag aataaacggc atgccgaaca catagggggt caccttattt 1070341 gcaaaaggga tgccgagtaa gattccgata aagggtaaag cggcaagaac gtgaatcagt 1070401 ttcatagaat cctccttcta tttaggattg aggtgtacaa gcctaagcgt actgaaaatg 1070461 atgtcgcaga tatcgcagca catgtcattt tttggagtga aaggctgtgg ttcgaattat 1070521 aaataaattt attttgtttg tatagtgtga attgtctgaa attaatgctc tgaatcgccc 1070581 gaagagggaa cgggcagtat gattcaaaag gctcagagtc tgtctggggc aaatagatag 1070641 tatgttaata attcgctgac ctgctcacgg attcgcggat taaaatagcg atggttttct 1070701 tcataaccgt cgatgacaaa tgtatagagt gtaaaggcct catcgcgttc cgtctcgcgg 1070761 attgcaattt ttcttttcct cagttctttt ctgacctcca tcaaatcctt ttgtgctatt 1070821 tttaatgatt cgctgataag ctgtttataa ggatgcttca attttaatgt gctttcttca 1070881 attccggcga gatcacggtt aaaaatcgta atggccatgg gcaaaaagag agcccgttca 1070941 attaaatcgt atatttcctc ctgcagattt ggcatattga ctccttcttt ctaagggaac 1071001 gtttgttcta tttgtattct atatcggctg gtgaaatgtt tcaagacaga aaaaatcacc 1071061 aaaacttttt agttttctgc tgataatgtg tagaataagg atagacaaac ccggtaagga 1071121 gtataaatgt tggagcattt tttatcctat ttgacacaag aacatttaac tgaattattt 1071181 caaagctata gggctttcgg tccgctcatt gctgtgctgc tgcctttaat tgaagcattt 1071241 ctcccgtttt tgccgctgat cgtgtttgtg gtggcgaata cgaactcgtt tggcttgtgg 1071301 gaaggattca tcctatcctg ggcgggatca actgctggtt ccattctcgt ctttttgatt 1071361 gtccgtcaat acggacagag aaaattgctt ggatttatcc gcagtcatcc gtctgtcaga 1071421 aagctgatgt tatgggtgga aagacacggc ttcggtccca tgtttcttct gctttgtttt 1071481 ccatttacac cgtcagccgc ggtgaatgtt gttgccggtt tgtcaaggat cggaacgcgg 1071541 ccgtttattt tggcggcagc ctcggggaag cttgtcatga tttttatgat cagcttcatc 1071601 ggatatgatc tgcacgcgct gattacacag ccgattcgaa cggtcatcgc cgtattggtg 1071661 atcactgtct tatggtatgt cggcaaaaag gtggagcggt atctgcatgt aagagccagt 1071721 cagcgtgagc atgatggagg gagacagtaa catgaaaaaa cggttttggt ttcttgccgg 1071781 tgtagtgtcc gttgttctcg ccattcaggt taaaaatgct gtctttattg attacaaggt 1071841 agaaggcgtc agtatgaacc cgaccttcca ggaaggaaac gaattgttgg tcaataaatt 1071901 ttcgcatcga tttaaaacca tccatcgttt tgacatcgtc ctttttaaag gccctgatca 1071961 taaagtgctg attaaacggg taatcggctt gcccggtgaa acgatcaaat ataaagatga 1072021 tcagctgtat gtgaacggaa agcaggttgc tgagccattt ttgaagcatt tgaaatctgt 1072081 ttctgccggc agccatgtaa cgggtgattt ttctttgaaa gatgtgacgg gaacaagcaa 1072141 ggtgccgaaa ggaaaatatt ttgtcgttgg agataatcgc atatacagct tcgacagccg 1072201 gcattttggt ccgataagag aaaaaaatat tgtcggtgtg atttctgatg ccgaataaaa 1072261 agacgctaat tgaagaggcg tctttttgta tgccgtttgg aaaaatgtgt tgaagaaaaa 1072321 tttgtaagga gctataatca aaattgttac ctgtgtaaca aaatttatat atttttttga 1072381 ctggagggcc gtttttattg gtttttgttc gtttttcatg aaacaaaagg agtggtgaat 1072441 gatgatgaaa tatgaagcag tgattatagg aggagggccg gttggattta tgctggcttc 1072501 tgagcttgca atagccggag tgggaacatg tgtgattgaa cggcttgaaa aacctgttcc 1072561 gcattccaag gcgttgacgc tgcacccccg aacgctggag cttcttgaga tgagagggat 1072621 tttagagcgg ttcgtatcca agggaagcaa gatacctacc ggacattttt caatgctgga 1072681 tacccgtctg gatttttcag gcttggatac gagctgtcct tacacgcttt tgctcccgca 1072741 gtccaaaaca gaaaagcttc ttgaagatca tgcacgaagc ctgggaacag aggtgtttcg 1072801 gggtgccgag gcgctggcgg ttacgcaaaa cggggaagcg gtccaaacaa tttttaagga 1072861 tcgggacggc agtgtacgga cgatcacaag caagtttgcc gttggggcag atggcgccgg 1072921 gagtaccgtc cggaaacagg cgaaaattga gtttccggga acagacagca ctgtcaccgc 1072981 tgcgcttggg gatgtggtgc tcctttctcc gccgccgtca ggtgtgctgt ccctttgcac 1073041 aaaagagggc ggtgttatga ttgttccgtt atctccagac cgataccgtg tcgttgtgat 1073101 cagcccttat cgcacacaaa cgccgaaaga tgtgcctgtg actgaggaag agctgaaagc 1073161 tgacctcctg cgaatttgcg gaactgactt cggtttaacc gacccttcgt ggatgtcgcg 1073221 gtttgggaac gccgcgcgcc aagcgaaacg gtatcgggac ggcagaatct ttcttgcggg 1073281 tgatgccgcg catattcatt ttccggcggg cgggcaagga ctgaatgtcg gccttcagga 1073341 tgcaatgaac ctcgggtgga aactggcggc ggccatcaaa ggctctgcgc cttcttggct 1073401 tttggacagc taccatgatg agcggcatcc ggcagcggaa gggctcctca gaaacacgga 1073461 ggcacagaca aagctgatcg atttcactca agcaggcctc catttgcgaa gcatgatgtc 1073521 ggagctgctg gccttccctg atgtgaatcg atatgtagcg gggcaaattt ctgcgctcga 1073581 tgtcagatat gaagctgatc gtaccatgcc gccgaatcgt ttgaacgggg caaggctccc 1073641 tgacatgaag ctgattcttt ccgacggcaa ttcggaacgg ctgtacagct ttctccaaaa 1073701 cgggacattc gttttgctgt cattgaggca ggaagctgat gatcatatcg aagtaaaagg 1073761 cttacgtacg gtaaccgcct cgcttgcaga accgaatgaa aagttgcgga atgtgcatac 1073821 catattgatt cgtcccgatg gacatgtagc ctgggcggtg gatgcatcag cgcccgattg 1073881 ttccgaggtg attcaaaaag ggatcagccg ctggttttcc gtcaccagcc gagtataatt 1073941 caattcgatt gtttcatctg taacaaaacg gtatgataga agaaacaatc gaatgaaaaa 1074001 ggatggaaaa cccgatgaac acagatcata cgaaacgcaa tctttttgaa ttgtatgcgg 1074061 agctcattca tcagcaggag aaatgggagg ggcttattaa agccttttta tctgacgaat 1074121 tgaggaagct ggatgtagag cacgggagta aatctcaatt gacgatgaca gaaattcatg 1074181 ttctatcctg tgtcggggac aatgaaccaa ttaatgtcac gtcgatagca gaaaaaatga 1074241 atacgacaaa agcgactgta tcacgcatca gcacaaaatt gctcggcgca ggcttccttc 1074301 acagaacaca gctcagcgat aataaaaagg aggtctactt ccgattgacg cctgctggaa 1074361 aaaagctgca cagtttgcac aaatattatc atcagaaggc tgaacagcgt tttctgtcat 1074421 tttttgaccg ctataccgag gaagagattc tttttgcgga acggctgttt cgggatctgg 1074481 tgacaaaatg gtatccgtcg tcagaagaaa ttgaaggggg gcttcctagc atttttaaat 1074541 aaaaaacacg cactgcggtg cgtgtttttc gctttgtttc tatctttttc aaggctgtaa 1074601 cgtaaatcag atttcctctt gaagaatgaa attcaagatg ttcaggaatt tgcactgctt 1074661 atacgatatg tctattagta tctttatttt atacgttttc tactgtgttt ttgatgcttt 1074721 gttttcaagt gaaatagggt cttctgtttt agttctccta atctttacag aaatacctac 1074781 tagaatgacc gccatagttg taaatattcc catggttaat aagatcgtat cctggtttaa 1074841 actccatcca attaagaaag agatgatcgc tcctccgaaa cttgccgagg caataaataa 1074901 acttgtaact tcgtcaacgt acttctgaat aatgattgat gctagtgtta aagcaatggg 1074961 aaatatcccc gctatactta ggccaatcaa aaatgtacca ctcaattgaa gtattgggtt 1075021 acttatataa gagaaggcaa tcaacaaaac aattaaacaa ctacagctaa aaagaaggta 1075081 tttggaaaaa tcaagccttc tacttacgaa accaatcaat attcttccta tgatgatccc 1075141 tacccagaaa aaggagacac ttataagact aatttgttca ttgtcttggt ttatcatgat 1075201 tgaaggtaaa aagttggcaa aatttgtttc aattccagca tataggaaag cgaaaaatac 1075261 aaaaaagcct aattgctttg atttttttct atctcctata aagtattgaa atgctcctcc 1075321 atctggaaag gtcacttgtt ggttagcatt cttagcgtac tctcggttct tagacaagaa 1075381 aattaaccac cctacgaata ggacgaataa aaaggtgaat atacagtaat atggtaaaaa 1075441 ccagttattg atatctatga aggaattaat taataatggg aaagataaag cgcctaatcc 1075501 aaagagaact tccagcttac tcattttttc tgcattactt tcgaaattag caataacaaa 1075561 tgaaccaact gtcgtttcta atgtgcctgc tccatatcct aagagaaaag ccattacaat 1075621 aatataatac caatccttgg ttagaaaaaa gatacttaac gctacaagca ttattgtcaa 1075681 agctaaagta agtgtcctaa aatgactgta tttcttaatc attaaaggtg cgattaatac 1075741 tccgcttaga aatccggtaa actggaagaa gattatgacc gaaatatcat ctgttgtctt 1075801 gttaaaagcc tctaataaaa atggtgtcaa actccctgtt gatatatgga taatacctac 1075861 tgtaaaaaag aaagcatatc caaataaata tgtccctctt aacattcatt acacccctat 1075921 atgaaaaagc aggaaagtaa attcctgctt ttttagtaac ttctctcttt gaaatactag 1075981 ttgactgctg aaacagacat gggttgagag ttgctgtctt tctcaaagaa catttctaat 1076041 acttcctgag atctaaaacc atcactaaaa gaagggatct caacccaatc attctgagtt 1076101 gatgcaatcc aattgattaa ctcgcttcta aaagaatcag cccatccata aaactcgttt 1076161 ggcggatcgt ttaataggct ttgcggtact gggcagtcta ccacgttcaa gccatctatg 1076221 agcttgtaaa cgtgaggatt acctgtgtgg tatttaaact cttttttgtg tccaactacc 1076281 tcaatgctaa aaccacagtc ttcaggtaca gaacactttg atgtgatgat atttacaaat 1076341 accttgttct tcagctggcc ataaatttct gcatagtcat ctacaagtac ctgtttatcc 1076401 tcttttgttt ttacatttgt gttcatcttt gcccttactg attctgtgat gaaatcactc 1076461 tcgaacaaat accataccat gtcaataagg tgaataccca gatcccccaa tgatccactc 1076521 gtcttcttac tattagcgtc atctctccaa gtaaacttct tacgtctaag tgcactattt 1076581 ttcttgaagt gtacttttat ggacagtatg ttacctagtt cattattgat aattaagctt 1076641 tttaagatat ttacgtaaga taaatatcta taattaaatc ccatactggc tcttacgctc 1076701 aacctttcag cagtatcttt cattatgctt gcttcttcaa gagaaatagc cataggcttt 1076761 tcacataata catgcttatg ttttcctaat gcttgcaaag catgttcttt atggcaaaag 1076821 tttggtgatg ctacaattaa accttctgag gcatcaatta gttcatctac gttttcaaat 1076881 gacttcccgc cgaaagtttt cacaaagctt tccgcatttt gttgatttat gtcatatacc 1076941 cctactaact ctgcattttt tattgtagat aaagcagttg catgcgctct tgcaatacca 1077001 cctgcaccta tgatgcctat cttcttcatt tttatttcct cctcatgatc caattaattt 1077061 ttttaaggta ttagtaattc cttttgagta ctcactatca gttataaggt tgtgcaagtt 1077121 tttggcttcc tgtgttgcat tttttagcag atatccattc cctactgtct gtaacatacg 1077181 aacatcattt ccactatccc caaatgcgat agctctttcg gtatttaggt tgtatttctc 1077241 taacataaac gttacaattt cattctttcc tgtccctatg gggataaaat ctacatcata 1077301 gctgtcttct ggatcgcctg ctaagggatt acaccgattt atatttactg aaacgccgta 1077361 ttcttcgcag attttttcaa tagctaatag gtttttcttg tcgtttattt catcttgttc 1077421 ctgatagtag aagttatgct tataccgtga ctttcctaat tgggtttgag gattcaaaag 1077481 aatgttatga ttttcatgca gctgtttcac aagtttttca accttttctt tactaaaccc 1077541 ttcatttatg cgactgttcc acttgttatc ttgctgaccg aagttatgct ctgaaaagta 1077601 cgtaatttca gttccaagat cactagctat aaaatgcgga aaatatctaa attttcctcg 1077661 tcccatttta tcgagaatag attctatact gctcccagta acccatccga ttattagctc 1077721 cccatcttta cttttttgtt ctagatagtc ttcgagttca tagatgtctt gttgcttttg 1077781 ttcgtcgatt gtatgcggaa aatacgtttc atcaaaatca caaaaaacaa tatattgagg 1077841 atgttcaacc gtggataacg ttttatactc cgatttcttg cttaataaca tgaaacagtc 1077901 cctccattac tctgtcttgt tcttctaaag taaatgacgg atataaaggc aaatgcagta 1077961 cctgactatg agccttttcc gtatgaacca attggagtcc tgcatacttg tcctgtacta 1078021 aaggagtttt ttgcatatga gaaagtattg gataatatac atctgtttga acaccaaaat 1078081 cttcatttaa tttagtcatg atatctgccc tatcttctgt tcttacctta ataggaaaca 1078141 gatgccatac atgatcttca cttaattctg gtaattcaat atagccttta ttctgcaact 1078201 ctgctaattg ggtaatgtat ctatccgcca agaacaatct tttgaagttg tttaatgaaa 1078261 ggtacttcat tctctctaaa ccaattgctg cctgtaaatt gtccattttt gaattaaatc 1078321 caaaattgat gactttctta ttttttacat ttacttcaaa accgtgataa ctaaattgaa 1078381 tgcatttttt agcgagttct tcattatcag ttgctattgc cccagccttg ccacatacac 1078441 caaaattctt atagggatta aaacttaatg tagtgatgtc tgcatacttt cctaagtctg 1078501 tcagtccaat tccttggcag gcatcttcaa ttacttttaa tttataacga tttgcgattt 1078561 gacggatatg ctgcatgtct gaatgttttc cgtataaatg cacaggtaga ataaactttg 1078621 tataaggagt tattgcttct tcaattttgt caggatcgat gcagaatgtt tgtgggttaa 1078681 tatctacata gataggaacg cctcccgaag ctaacacagc attttcagta gctgaaaagc 1078741 tattagccgg catgataact tcatcccctg ggtttaaccc taaagccaat aaacctatca 1078801 taatagcatc ggttccactg ctggttgcaa ttacatacct tttatgtaaa tatgtagata 1078861 aaactttttc gaattgctct aaatagggac cactcgtaaa ttttccagtt ggcaaaactt 1078921 cagttaatgt atttaagata tcttccactt catcattggt tattaatctg tctacaggca 1078981 aaaaagggac tttactgatt tcacgatttt tttgatagtt gaaaaggtca tgttcaatat 1079041 ctatcttttc ttttaatact tgtttccacc gctcgtttac aatactgtct tcaataacaa 1079101 gttcttttcc ttgtacgtca ccttttaagt gttttaatag tgacatgttt tctttgcttt 1079161 tacctgaaat cttaacctgt ttttgcatga acagtacctc caatgatttt ataatctaaa 1079221 aatttattac aaatttatcc tagtttctga aatcggtaac atgtcaacaa cttttttaag 1079281 gaagggaaaa tatgcctaca attgatgaaa tagcaaaatt atgcaatgtg tctaaaacca 1079341 cagtgtcaag agtattgaat aatcatcctt atgtgtcgaa agaaaaaaga gatatgatct 1079401 taaaggctat taacgaactt gactacactc ccaattattt agctcggaat tttaggagaa 1079461 ataagacaca aacgatagct ttatcggttc cgagtatcga ccatccattt tttgctcaat 1079521 taataaaagg ggtctctcat gaagtactgt ttaagaatta caaggtaatt gtatttcaga 1079581 ccttttatga caaacagacg gagctagaat tactagagtt attgaagcat aaagaagtgg 1079641 atggcattat tcttgggact ttagaaaatg aatgggatca gatatcccct ttcttaaagt 1079701 atggtcctat cttattatgt aatgaatatc atcactcagc ggacatcacg ataattgggt 1079761 atgatgaatt tgaagccgca tacatggggg tagtacattt aattgaaaga gggcataaaa 1079821 aaattgggtt ttgttttgat actccatata gcgaagctca atgtcagagg aaagagggtt 1079881 atttgaaagc tttacaagat tacaatttac atcatagaag cgaatggata ttcggcgaaa 1079941 tgtttaatat cgaggatggc tttcgtgttt ttcataagat aaaggatcta aaggacagac 1080001 cctcagcaat atttacagga aatgatcaag tcgccgcagg gattattaaa caggcgatga 1080061 aaaatggctt taaagttcca gaagacttag ctgtaattgg ttttgacaac caattgattt 1080121 gccaagtcgt tactccgacc ataacaacaa ttgatatccc cgtaatagaa ttaggccaac 1080181 aggctgtgtt gaaaatcatc gagtccattt cgggtaatgc ctctttaaac agaagaatta 1080241 ttaaactgcc aacaaagctt attataagag aatcaacgta acgatagatt tccctttaac 1080301 attttatatc tttatataag aaaaagaggt tattcatttt aacctctttt tcaatcgtaa 1080361 gtcgtcaatt atttctttca tttcaccctc tggcagcact cacttcaaat ctgatccatt 1080421 aacaacgaaa tatccgctta tatttcctca tctcgatggt ttgcgaatta aaagttcttg 1080481 aacccttttt tcaactaggc actactgccg ctgattgagc tctttttgtc ttttttttca 1080541 ccatgaagat ggtgaagcag gcgataaaac ggcggcagca gggcaataac cagaatgacg 1080601 cgaatgacct gaaccgcaac gacaaaggtg gaatcagcat gtaaggtaac tgacgtcgtc 1080661 gccatctctg caatcccgcc gggcgcaaat gccagaacag aagtgatgag cgaaattcct 1080721 gtcagctcgg aaacgatcac ggcgctcaaa aacattgctg cgattaaacc gacggacgag 1080781 acaaacccga cgatgataat acgggtgacg ccggcaaaca tgcttttgta catcttagag 1080841 ccgatcgttg ccccgagaaa tacttgtgat acatggttag cttgtgacaa ccaccatgcc 1080901 gtcatgtcgt gccctgtcac cgcagctccg ccaacatgta caattgctac accgagcatg 1080961 ctgccgagca gccatggagc tggaaatttt aaaaatttcg cagctttgca agctccccag 1081021 gcagcgagaa taagaatgac ggtccacaaa acgggagcga gcctaaaatc tgtcgttgca 1081081 gaagaaatcg tctctgctgc ggcacttgcg gtacgatctt gttttgtata gatcagaatg 1081141 actaaaaacg gaatggaaag caccacgagc agcacacgca tcatttgaac gaggctgact 1081201 atagcggtat tggcgcctac ttcctgtgcg atgctcggca tggcggaaag tccgccggga 1081261 gcggtgccga caaagctagt catcatatcc gttttgctga aacgccaaag cacatatcct 1081321 gacagcatgg ccagcaggat agacaatatc agcataacgc cgactgaaaa ccaatggtct 1081381 ttgagaacag agagaacgga taaattcagc ttttggccca attcgatgcc gaggatcatc 1081441 tgcccgaggg cgagccatcg tcggttaatt cctttttggt ctggtgccat catcagccat 1081501 gccggccgta tcatggcgag gcagcaggcg acaatcagtg ttccgatcat ccatccaatt 1081561 gatattccgg ttaatgaaag aataaacccc ccggctgcac tgattgcgat aaaccataga 1081621 tctttgagga gattttcgtc tttcttcaat gtaaaaccct tcttcctttt tcacgtaaca 1081681 ctccaattgt tcacgtagtg aatgtattta ttactatagt atatttttgt tgataaagaa 1081741 attatgaatt attttctata agcgattcac ttttcttatg accttgtgtt cgagcttttc 1081801 tattgtgtaa gtcagagata aacccgctgt cagcagacac acggcaagag cgtaaaaaat 1081861 cacttctccg ccaaatgatg tcaggatcag cccgcctgcc agcggtccga ttgagcggga 1081921 tatatcccaa tgcagaccat agacagcata aaaccggccc agcaaatgag gcggcgccaa 1081981 tttcgatatg aaggtctgga tgtgggttag cccgatgctt tcaccaaccg tcatcaccgc 1082041 tgccgtcact aaaagcattg tcagagaggt tgagcatgca aagccggctg ccgcaaggga 1082101 gtagcaaata taagtaatga agaggatcgt tttcattgaa agcttttcgg tccctttgac 1082161 aagaggtact tggagaacac agctgaataa agcttttgct gctgaataga tggtcagcat 1082221 ggacagataa tcagaaaaca tgtttttgct gaacagcctg tatgttgttt ctgtttgtgc 1082281 atataacatg ctgatgggga gagaaagcag caaaagaagc aggacaggcc tgtatattgt 1082341 aaagctcgcg gacattttcg gggtaacagc tgggtgtagc ggctttgtct caggcagttt 1082401 cagtgcagcg atcagaaagt agataaacaa tgctgcagca tctaatgcga atatccacac 1082461 ggggttatga ttgtacagca gcatccccac tagcggtcct gccgtcagac ccgtcgaata 1082521 gatcgcattg atgaccgcaa acacttccga acgtctgctt tccggcgtgc tttcagcgat 1082581 ttgggcgcgg gaagcgggaa tgtacaacga tcttccgatg ccattcatga catagagaat 1082641 agcgaaaaca tacgcatgct cagcaaatac aaaccctgtc attgccgctg attgaagaag 1082701 caatgcggtc aaaatcgctg tgcgccgccc aagccgatcc gtcacccgtc ctgcagcgag 1082761 cgtcaggaaa atatcagcaa atggctgaag gctgatgatc agcattggca tcatgatact 1082821 gccgtttaat tgttcatgca gatacagcac cataaaaggt cccatcattg cacctgtcag 1082881 gcttgtcagc aattcgccga aaaagcggag ccgaacggga gcggtatatc tcgattttat 1082941 agagtgaaaa ctggtcaaca tgtgatcgcc gcctttcgct gtttgatata gtagtagtgt 1083001 atagaagggg cggcggccca aaaagtgaag aaaagaagag ataaaagttc cccttttgtc 1083061 gggaggtgcg gggattgaag ctgatagagc actacgtggc gcttgtaaaa acaggctgcg 1083121 ccgagtatgg gcaaatgaac gaaatgacgc tcactgagat tgccgactgt ttattttgta 1083181 cagaaagaaa tgcaaagctc attttacata agctggagaa cagcaattgg attatccggg 1083241 aaagcggggc ggggcgcggc cgcaaatcta aaatcgcgtt tcttcggagg cctgaggaac 1083301 tgcttcttca aactgcaaag gaatatacca tgtcaggaaa gcttaaaaag gcaaaggagc 1083361 tgcttcagca gtatcagtcc gcgtttccag ggcttcaaaa cgaatataac atgtggctat 1083421 cagaggtatt cggatttgtg acggagacag gcgagaatgg ggcgaaggat gtcctgcggc 1083481 tgttcatcac gcctgaatct gtcagcagtt tggatccatg ccaaatattt ttgcggtctg 1083541 agggccattt cgtcaaacag atatttgata cactcttcac gtttgattcg gatatgcagg 1083601 agccgaagcc tcatttggtt catggatggg aagaggtcgg aaaaaaacaa tggagatttt 1083661 ttcttcgaaa aggtgtgtta tttcataatg gacagccgct gacatcgcgg gacgttgcgt 1083721 ttacatttca gcgctttttg gaactggctg acaacccgta taaatggctt ctgcacggag 1083781 tgaaacaagt cttagaaaag ggcccttatt gtgtggagct catactcgat aagccgaatg 1083841 cgcttttgcc gtatgctctt tgtgatgaac ggctgtccat actgccggca gaacagggcg 1083901 gcgggaaaaa tggaacaggg ccttttcaga tgaatcagca acatagcggg atgcttgtgc 1083961 ttgaagccaa tgagcgctac ttcaagggac gcccctattt ggatcgcgtt gagtttgtgt 1084021 tttctgagca agccggagag atgaacggtt ttaccattca agaaaaacaa acatgtcctg 1084081 agcagcaaac tgtctttgat gagcggcatg ttcagtattt gtcgcttaat ctgaaaaaga 1084141 aggggcctct tcagcaccga agctttagaa aagcgctccg gctgctgatt tcctctgaac 1084201 ggctcgttcg tgaagcggga gggcaccgaa gaattccggt tacgtccttt ttgcatccga 1084261 gtccttttga gtgggagggc gtttcgccat ctgaattgtt gaaaaaaagc ggatacgagg 1084321 gcgaaacaat cgtgctttat accttttcgg aaacggatca tcgtgaggac gccgaatgga 1084381 ttcaaaatat ttgcgcccag cacggtatca ggcttacact tcaattctgt gatgctgctg 1084441 atctgcgacg gccggaaatc gtgcagatgg cggatatcat tcatgacagt gcgacgtttt 1084501 atcaagacag cgagtttggt tttctgcatt tgctgctgtc ggagaacagt ttcttgtatc 1084561 agcatctatc tgaaaagctg acacagattt gctcaggaat gacagagcgg atgttttcca 1084621 tgcctgaccg ctgttcgaga atcaacatcc tgcgtgacat tgaccggcag atgatacagg 1084681 agctgaacgc gatcccgctg tatcaaaatg tgctccaggt gacatcaagt aaaaatgtaa 1084741 aaggcctggt gcttgatgaa gagggatgga ttgatttgta ctccgtatgg ctgtccaaat 1084801 aaaaagaggg ttcttttttg aaccctcttt tttacgctgc catgctgcgg cattgttcag 1084861 cacaggtgaa gcaggctttc gcacatgctt ggcaatgatc atgatcgtgc tttccgcatt 1084921 cagtgccgca tgcttcacaa atatcggcgc aaagtgcaca aatttctttc ataaacgggc 1084981 tgtccgtttg catggctttg accgccagcg cgcaaatatc cgcgcattcc ctgtcaagcc 1085041 ggatgcatcc gctgagatga tgctgcacgc tttcttccaa gcatttagtg aaacaatgat 1085101 tgcaagcctt catgcaatcg atgcaagcct caatacaagc ctcagaatat tgctccatgg 1085161 ttgattcccc ctgtatgaca gtatatggtt ttatgtttca cggctgcatt tgaaaaaaac 1085221 aggggagtgt gtttttagct aaggggatat gtacatatac cctgaatggg tatatctaac 1085281 gttccatcag atagtatagg aaccagacag cgtgattttg ttcatcacgt gctgcgcgcg 1085341 taaagacgcc tttcgctttt aagtttgacg tttcctcggc cgcacgcaag taaaagtcga 1085401 cggtttcttg ttcatcttta aaagcggcgt ccagtcctct tgtgaaattg tccgggcatt 1085461 cttccgtttg tttcggcatg atgtgtttgc cggtaattga accatacagt gtggaaaatt 1085521 cacggaggtg gcgaatctcg tcacgcctga tttcttcaat ctgttttctg acctcatcgc 1085581 tgtgggcgag ttcggcaagc ttgcggtagc attgaatagc actgaattct ccgttgatgg 1085641 ccttctgcaa attccgaatc aaaacaggat cttcccggta tggcaccgga tagggatagt 1085701 agctgtaatg caaggggatt caactccatt cttaggaatt gggcttctgt aaaagtatat 1085761 gttgggcagg gagagatgtg cggagataat cagcttttta tatgtgaaaa ggccgttttt 1085821 accaatagat cagattggtc attttcgtca acattcgata aaatatagag agataaaaag 1085881 agaggggtct tctaatttgg gagcagagtt tttagtaggc aggtccggga gtggaaaaac 1085941 gaagctgatc atcaacagca ttcaggatga attgcgccgg gctccattcg ggaagccgat 1086001 catttttcta gtcccggatc aaatgacgtt tttaatggaa tacgagcttg ctaaaacgcc 1086061 agatatgggc gggatgatac gcgctcaagt gttcagtttt tcacgattgg cctggcgcgt 1086121 cctccagcat acgggaggaa tgagcaggcc gtttctgacg agcaccggcg tacaaatgct 1086181 cctgcggaag ctcattgagg agcataaaca ggagttcaaa gtctatcaaa aagcgagtga 1086241 caaaagcggg tttaccgcac aggttgagcg gatgctgaca gagtttaagc gctattgtct 1086301 ggaaccggag gatatccgcc ggatggcgga aagcggaacg gcttccgagt atcgcggaga 1086361 acgtgtttta tctgaaaagc tccatgactt atcaattctg tatcagcaaa tggaaaaaag 1086421 cctcgcagat caatatcttc actctgagga ttatttgaca ttgctggcag agcatatccc 1086481 gcttgcggaa gatataaaag gcgcccatat ctatgtggat ggcttttatc agtttacccc 1086541 gcaggaattc agggtgttgg agcagcttat ggttcatgcg gagcatatca cgttttcgct 1086601 cacagcggac aagccgtcat atgagcggga gccgcatgaa ctggaattgt tcagaatgac 1086661 ggggaaaacc tattaccgcc tgcatcagaa ggcgaaggaa ctgaatttgg acattacgta 1086721 taaagagctg agcgggactg agcggcatac aaagacgccg gaattggcgc atctagaggc 1086781 acagtatgaa gcgcgtccgg ccattccata cgcagaaaaa caagaagccc ttactgtgat 1086841 gcaggccgca aacagacgag ctgagctgga aggcattgct cgggaaattc acgccctagt 1086901 cagagagaag ggatatcgct ataaggatgt agcaattctt gcgcgccagc cggaagacta 1086961 caaggatatg gtgaaggaag ttttcgcaga ttacgagatt ccttatttca ttgacggaaa 1087021 agcatctatg ctgaaccatc cgttaattga atttatccgg tcgagccttg atgttctgaa 1087081 agggaattgg cgttatgaag cggtgtttcg ctgcgtgaaa accgaactgc tattcccgct 1087141 caatgaaccg aaggccaaag tgagagaaca ggtcgatcag ctcgaaaatt actgtatcgc 1087201 ctatggtatt aaaggcgacc gctggacaaa gggcgatcgg ttccaataca ggcgttttgt 1087261 gtcattggat gatgattttg cgcagactga tcaggaaatc gaaatggaaa acatgttgaa 1087321 tgacacccgc gattggattg ttccgccgct ttttcagctt caaaaacgca tgaaaaaagc 1087381 gaagacggtt caagagaagg cggaggcgct ctatcgttat ttagaagaga cggatgtgcc 1087441 gctgaagctg gatcaggaaa ggcagcgtgc tgaggatgac ggcagaatca ttgaagcgca 1087501 gcagcatcag caggcgtggg acgcagtcat tcagctgctt gaggagtttg ttgaaatgat 1087561 gggagatgat gagatttctc ttgatttgtt tcagcaaatg atagaagccg gcgcggagtc 1087621 gcttacattt tctctaattc cgcctgcgct tgaccaggtg tttgtcggca atatggattt 1087681 gtccagaatg tatggcacct cctgcacctt tgtgctcggg gcaaacgacg gcgttctgcc 1087741 ggcacgccct gatgaaaacg gggtcctgtc ggatgatgac cgggaatggc tgaaaacgat 1087801 tggggttgag ctatcctcag gcggacgaga gcgtttgctt gatgagcact tcctcatcta 1087861 catggcgttt tcaagtccgt ctgaccggct ttacgtatcg tatccgattg ctgatgcgga 1087921 aggaaaaacg cttttgccgt cgatgatcgt taagcggctg gaagaactgt ttccgcatca 1087981 taaggagcgc ctgttaacaa atgaacctga acaggtcagc gatgaggaac agctgatgta 1088041 tgttgtgaat aaaagcgtgg cacagtcctt taccgcgagc cagctcaggt tatggactcg 1088101 ggaatacgac atcagcgacg tctggtggag cacgtacaat gtgctgatga gtgagcagga 1088161 caggctgcaa tcgaaaaagc tgttctcaag cctgtttttc cggaatgaag tgaagcagct 1088221 tgaacgcagc gtgtcgagac agctctatgg tgaacgtatt cagggcagtg tatcgagaat 1088281 ggaaaccttt aacgcatgcc cgttttccca ttttgcgtca cacgggctgc atttgaagga 1088341 acggcaattc ttcaagcttg aagcaccgga tatcggccag ctgtttcatt ccagcttaaa 1088401 gctgatttcg gacaggctgc gtgagcaaaa gctggattgg cgcgatttaa cgaaggagca 1088461 gtgcgagctg ttttcctatg atgcggtaga gcggctggca ccgaaactgc aaaaggaaat 1088521 tctgctcagc tcaaaccggc attattatgt gaaggaaaaa ctgcaaaaaa ttgtgacacg 1088581 tgtgtccggc attttaagcg agcatgcgaa agcgagcgga ttcgtaccga tcgggcttga 1088641 actgggcttt ggaggaaaag ggccgcttcc gccgctgacc tttcaactga aaaacggctg 1088701 tacgatggaa ctcgtcgggc gaattgaccg tgttgataag gctgaaagct caaaaggcct 1088761 gctcctcagg attgtcgatt ataaatcaag cgacaaaggc cttgacttag cggaagtata 1088821 ttacggattg gcactgcaaa tgctgacgta ccttgattta tcgattacac attcagctga 1088881 ctggctcggg atgagggcga cgcctgccgg agtgctgtat ttccatattc atgacccgat 1088941 gattcaatct aatctcccgc ttgggcttga cgagattgaa caggagatct ttaagaaatt 1089001 taaaatgaag ggcttgctcc tcggtgatca ggaagtggtt cgcctcatgg atacaaccct 1089061 tcaagaggga cgttcaaata tcataaacgc cggcttgaaa aaagacggct ctctcagatc 1089121 agactcagca gcagtcggtg aaaaggaatt tgatcttttg acaaagcatg tgcgccgcac 1089181 cttccaagaa gcgggcgaac aaatcaccga cgggcgcgta tccattgagc cgtacaaaat 1089241 gaagaacaag acgccgtgca catactgtgc gttcaaatca gtatgccaat ttgatgaatc 1089301 actggaagaa aacgagtatc gcccattaaa ggctgaaaag gacaagacaa tacttgagtg 1089361 gataaaaaag gaggcggatg gcaatgaaca ttcctaaacc ggcagacagc acatggacag 1089421 atgaccaatg gaatgccatt gtttcaaccg gccaggatat tcttgtggca gcggctgcgg 1089481 gctctggtaa aaccgctgtg ctcgttgaac gaatgattcg gaaaatcacc gcggaggaaa 1089541 acccaataga tgtagaccgt cttctcgttg tgacatttac aaacgcctca gcggcagaga 1089601 tgaagcaccg aatcgcagaa gccttggaaa aagagcttgt acagcgcccc ggctcgctgc 1089661 atattagacg ccagctgtct cttttaaacc gggccagcat ttcgacgctc cattcctttt 1089721 gcctgcaagt gctgaagaaa tattactact tgatcgatct tgatccgggc tttcggatag 1089781 ctgatcagac ggaaggcgag ctgatcgggg atgaagtgct tgacgagctg tttgaagacg 1089841 aatacgcaaa gggcgaaaag gcgttttttg agcttgttga ccgctatacg acagaccggc 1089901 atgatctgga tctgcaattt ctcgttaaac aggtgtacga gtattcccga tcccatccca 1089961 acccggaggc gtggctggaa agctttgttc atttgtatga tgtatcagaa aagagcgcca 1090021 tcgaggagct gccgttttat caatatgtca aagaagatat tgcaatggtg cttaacgggg 1090081 cgaaggaaaa gctcttgcgc gcgcttgagc tgacgaaagc gccgggcggc ccggcgccgc 1090141 gtgctgacaa ttttcttgat gatcttgctc agattgatga actgattcag catcaggacg 1090201 atttcagtga actatataag cgggtgcccg ccgtctcttt taagcgtgcc aaagcagtaa 1090261 aaggggatga gttcgatcca gcgctccttg atgaggcgac agatttgagg aacggcgcaa 1090321 aaaaactgct tgaaaagctc aaaaccgact acttcacgcg aagtcctgaa cagcacttga 1090381 aaagcctagc cgagatgaag cctgtcattg aaacgctcgt acagcttgtc atcagctatg 1090441 gaaaacgatt cgaagctgcg aaacaggaaa aatcaatcat cgatttttcg gatttggagc 1090501 attactgttt agcgattttg acagctgaga atgacaaagg tgaacgtgag ccgagcgagg 1090561 ctgcaaggtt ttatcaggaa cagtttcatg aggtgctcgt tgacgaatat caggatacca 1090621 acctcgtgca ggaatcgatt ctgcagctcg tcacaagcgg tccggaggag actggtaacc 1090681 tgtttatggt aggagatgtc aaacagtcga tttatcgatt caggcttgcg gagccgcttc 1090741 ttttcctctc taaatacaaa cggtttacag agagcggaga aggcacgggg cggaaaatcg 1090801 atttaaataa aaatttccga agccgggctg atattttaga cagcacaaac tttttattta 1090861 aacagctgat gggcggcaaa atcggtgagg tcgattatga cgagcaggct gagctgaagc 1090921 ttggtgcagc gtatccggac aatgacgaga cggaaacaga gctgctgctg atcgacaacg 1090981 cagaagatac ggatgcaagc gaggaagcag aagagcttga aacggtgcag tttgaggcaa 1091041 aagccatcgc taaggaaatt cgtaagctga tttcatcgcc gtttaaggtg tatgacggaa 1091101 aaaagaaaac acatcgcaat attcaatacc gagatatcgt gattttgctc cgttcgatgc 1091161 cgtgggctcc gcaaatcatg gaggagctga gagcacaggg cataccggtt tacgccaatt 1091221 taacgtcagg ctattttgaa gcggtcgaag tcgccgtcgc gctttctgtg ctgaaggtga 1091281 ttgataatcc gtatcaggat ataccgcttg cctctgtgct gcgctcaccg attgtcggag 1091341 cagatgaaaa cgagctgtct ttgatccggc ttgaaaataa aaaagcgccg tactatgagg 1091401 cgatgaaaga ctacctggct gctggtgacc ggagcgatga gctttatcaa aagttaaata 1091461 cgttttacgg acatctgcaa aaatggcgcg cgttttcgaa aaaccactca gtatctgagc 1091521 tgatttggga agtgtaccgc gacaccaaat atatggatta tgtcggcggc atgccgggcg 1091581 gaaaacagcg ccaggccaat ttgcgtgttc tttatgacag ggcgcgtcaa tatgaatcaa 1091641 cggcatttcg cggcttgttc cgtttcctgc ggtttatcga acgcatgcag gagcggggcg 1091701 atgatcttgg tacggcgaga gcgctcagcg agcaggagga tgttgtccgc ttaatgacga 1091761 tccacagcag caaagggctc gaatttccag tcgtgtttgt agcaggtctc ggccggaatt 1091821 tcaacatgat ggatttgaac aaatcgtacc tgctggataa ggagctcgga tttggcacga 1091881 agtatattca tccgcaatta cgcatcagct atccgacact tccgctcatt gcgatgaaga 1091941 aaaaaatgcg cagggagctg ctgtcagagg aattgcgtgt gctctatgtt gcattaacga 1092001 gagcgaagga aaagctgttt ctgattggct catgtaagga tcatcagaaa cagcttgcaa 1092061 aatggcaggc atccgcgtcc caaactgatt ggcttctgcc ggaatttgac cgctatcagg 1092121 cgagaacgta tctagatttc attgggccgg ctcttgccag gcacagagac ttgggggatt 1092181 tggctggtgt gccagcacac gctgacatct caggtcaccc ggctcgtttt gccgttcaaa 1092241 tgatccattc ctatgatttg cttgatgatg atctggaaga aagaatggaa gaaaaaagcg 1092301 agcgcctaga agcgatccgc cgaggtgaac cagttcccgg ctcgtttgcg tttgatgaaa 1092361 aagcccgcga gcagctgagc tggacctacc cgcatcaaga agtgacgcaa attcggacaa 1092421 agcaatcagt ttctgagatc aagagaaaaa gagagtacga ggatgaatac agcggcaggg 1092481 cccctgtaaa accggctgat ggaagcattc tgtacagacg tcccgctttt atgatgaaaa 1092541 aaggcctgac agcggcagag aaagggactg ccatgcatac ggttatgcag catatcccgc 1092601 tgtcacatgt gccgtcgata gaagaagctg agcagacggt tcacaggctt tatgaaaaag 1092661 agcttctcac tgaagaacaa aaagacgcta ttgatataga agaaatcgtg caatttttcc 1092721 atacagaaat cggcggacag ctgatcggtg ctaagtggaa ggaccgggaa ataccattca 1092781 gcttagcgct tccggccaag gagatctatc ctgatgcaca cgaggcagat gagccgcttt 1092841 tagtgcaggg tattattgac tgtctctatg aaactgagga cggattatat ctattggatt 1092901 ataagtcgga ccggattgag ggcaaattcc agcatggatt tgaaggagcg gccccgatct 1092961 tgaagaaacg atatgaaacg caaattcagc tgtacacgaa ggcagtggag caaattgcaa 1093021 aaacaaaggt aaagggatgt gcgctttatt tctttgacgg agggcacatt ctgacattat 1093081 agcgagatcc ataagctccg gaatttcagg cggagcgggt ctcgttttct atataaaaga 1093141 gaggtgaaag catttgcgga ttttacatac ggctgactgg catcttggaa aaacgcttga 1093201 aggaagaagc aggctgagtg aacaggccga tgtgctggat gaactgaata cgattgtaaa 1093261 ggatgagcag atcgatgcca ttgtaatggc gggggatgca tttgacaccg taaacccgcc 1093321 agctttagcc gagcagctgt tttatgaaag cctgtctgcg cttagcgaca gaggaaagcg 1093381 cccgatcgtc gtcattgccg gaaatcacga taatcctgac cgtttgtccg ccgcttcacc 1093441 gctgacacat gaaaacggca ttcatttaat cggttatccg acaacagagc cgattcatat 1093501 tgaagtgcct tcagcaggag agcttttggc ggttggagcg ctggcgtacc catctgaagc 1093561 gcggttaaat gaagtgctat ccgatacgtt tgatgaaaag ctgctccgtg atcactatga 1093621 tgtgaaaatc aggcaggcgt ttgagcatat gacaagccgg ttccggaccg atgcagtgaa 1093681 gattgccgcc agccatattt atgtggcagg cggaaaccaa accgattcag agcggccgat 1093741 tgaagtcggc ggtgcataca cggtggctgc tgaaagcctg ccggcagatg ccgcttacgt 1093801 tgcgctcggc catttgcatc gcccgcaaac gatcaagcgg gcgcggacgc ttgcgcgtta 1093861 ttcaggatct ccgctcgcct acagcttttc tgaagcgggc tacgctaaat cagtgacgat 1093921 tgtggacgca aagcctgggg aagaggccac ttggcaagag gtgttattat caagcggcaa 1093981 gccacttgtg aagtggaaag cggcaaatgg attaagtgag gtgtacagct ggctggatga 1094041 aggcagagat cagaatgctt ggattgactt ggaaatccgt gtcgcggacc agctgtcact 1094101 tgaagagatt cacaggctgc ggaaggcgca cccgggcttt atccatatca ggccggtttt 1094161 tgaagaacag aacaaagacc gggaacggat cgaggttaaa catgtctcaa tcgaggaccg 1094221 ctttaagaaa ttttatgaaa aacaaactgg cggtgcggtg ccggatgaag aaatggtgaa 1094281 gctgttttta gagcttgcat caggcgttga agaggaggat gcgaaatgaa gccgatcgcc 1094341 ttaagcatta aggggctcca cagctttaga gaggagcaga cgatagattt tgaaggcctt 1094401 tccggtgccg gtgttttcgg cattttcggc ccgacaggaa gcggtaaatc ctctatactc 1094461 gacgcaatga cgcttgcttt atacggaaag gtggaacggg cggcgaataa tacgcacgga 1094521 atcttaaatc acgccgaaga tacgctgtct gtgtccttta cctttgcgct tcagacgaat 1094581 caccaaatct catacaaagt cgagcgtgtg tttaagagaa cggatgaaat gaaggtaaaa 1094641 acggcacttt gccgcttcat cgaaatcaag gacgagcata cggtgctggc tgataaagcc 1094701 agcgaagtga ataaaagagt ggaggagctc ttagggctga cgatcgacga ttttacgaga 1094761 gcggtggtgc tgccccaagg gaaatttgct gaatttctgt ctttaaaagg ggcagagcgc 1094821 aggcatatgc ttcagcgttt atttaatttg gagcaatatg gagacaggct tgtgaaaaag 1094881 ctgagacggc aggcgcagga agccaatgcg agaaaaaatg aaatgcttgc tgaacagtcc 1094941 ggtctcggtg aggcgagctc agaggcagtg gagcaggctg aaaaggttct cgaacaagct 1095001 gaagcccggc tggaagcgat gaggaagaac cgtgatcagg cgaaggagcg gtttacagag 1095061 catcaggaga tatggaatgt ccaaaaggaa aaatccactt atgaagaaga ggaaaaacgt 1095121 ctcgcagaag aacagccgca tatagacagc atgcaaaaac gcctgctgga agcagaaaca 1095181 gcagcagccc ttaagcccta tgcggaccgg tacgcagaag cgatccagca tgaggagcaa 1095241 gctgaaaagg aacaaacgct agcccaaaag gatttagcag accggacagc tttctttcag 1095301 caaaaacatg aagagtatga agcgtggcgc cagcataaaa gcgagaaaga gcctgagctt 1095361 ttagccaaac aggaacagct ttcacgcttg caggaaatcg aaatcaaact gagtgaggcc 1095421 aagcaagagg aagagcgcaa aaaggctgac ctccggcaga aagaagaggc tcttcaatct 1095481 gtcatgaatg aattagagac cgtaacagac cgcctgacac gagggcaaaa cagacagaca 1095541 gaattgaagc agcagctcaa atccctgcag gtgacatccg atgagcgaaa aagctgccag 1095601 caggccgcag agatggcatt gcgcatcaga caaaccgagg aacaaatcaa aaaagagaaa 1095661 aaacgaagtg aagaattgaa cctcgtgctg cagaagatga atgaagagaa gaatacactc 1095721 gttcaaaaga cggaagcgga agaaaacaac atcattcagg catatgaggc agttcaaact 1095781 gtgtaccatt tggtgtgcga aacggaacgc tcattaacac gtatgacgga agaggctaga 1095841 aagagtcaac acacgcttca cttacagcgt gaaaaagcaa gggtggcact gctgacaaaa 1095901 gagttagccc aaaagctgac tgccggaaag ccttgcccgg tatgcggttc aaccgatcat 1095961 gatccatctg cctcggtaca tgaaacgtat gaagccgaca gccatcttga agaggacatc 1096021 aaacggacag atgtgttatt gacggaagct gcagctctca gccaggagat tctttcagcc 1096081 aaaattatgc ttgaagaaca gtccgcgcgc tttattgaac agtgtccgtt tttgcagaca 1096141 attcaagcac agaaccttga agcggcagct tccttcgaac atcagccggt gtatgaagca 1096201 tttgaaactg ccaaatttga atggaaacga atcaagcagg acattctttc tgttaagaca 1096261 cgaatggcac aaatgattgg cgcctatcag gagtctttaa aaaaggccga gcagcttaat 1096321 gaaaaaatcg gttttgaaaa aagagaagcc gaccgtattg aaagcatcat cagtgagctt 1096381 caatcctcaa tggacagcag tctgaacatg tttaaagaag catttcagaa tcaatctgtg 1096441 gacgaagcag aaaaatggca gcaagccatt gaagaaaagg accgggctgc agaagaatgt 1096501 gaaaaacgaa ttgagaagag tatcgcgttt cttgctgagc atgaagcaca aaaggaaaaa 1096561 ctgcgggaat cgggacaccg gcttgagcgg gaaaagctgg agcttcatta tgcggctgaa 1096621 cgcatcaaga gcgtgatagc tgattatgag cacgaactcg gagattatgc aaaaggagat 1096681 tcgattcaaa tcaaactccg ctctgtccag caggatctaa agctgttaaa ggaaaaagaa 1096741 caatctttat atgaagaact gcaaagcgcc caaatgaagc tcaaccaagc gaaaagccgc 1096801 gcttctgcaa gcgagctcac tcttcaagag gcgaagggca gattggaaaa agcaaaagct 1096861 gcttggcttg agcatacaaa aaacacctcc attacccgga ctgaggaggt tgaacaaagt 1096921 ctcatcccag ctgatgaact tgaaaagatg aaaaccggca tagaccagtt tatggataaa 1096981 ctgaagcaaa atgctgcaaa cttaaaacga gtagcagaga tacttgccgg cagagcatta 1097041 tcagagagcg aatggaacga aaccgttgca gcattacaag aagctgagga cgcatttggc 1097101 gctgctatag aggaaaaagg cgcggccgca aaagcactgg ctgtcattcg cgaccatcat 1097161 aaacggttta atgaaattga agctgaactg aaaaaatggc agatgcatat cgacaggctg 1097221 gacaagctgc aagctgtgtt taaaggcaat accttcgtcg aatttttagc tgaggagcag 1097281 cttgaaagcg ttgcgaggga cgcctcagca agactcagta tgctgacaag acagcgctat 1097341 gccatcgaag tagattctga gggcggcttc gtgatgcggg atgacgcgaa tggaggcgta 1097401 cgacgcccgg tttccagttt gtctggagga gagaccttcc tcacctcgct ttcacttgct 1097461 cttgcgctgt ctgcgcagat tcagcttcgg ggggaatacc cgctgcagtt ctttttctta 1097521 gatgaaggct tcggcacact ggatcaagat ctgcttgata cggttgtaac ggccttggaa 1097581 aaacttcagt cagacaacct ggctgtcggt gtcatcagcc atgtgcagga actgcgtgca 1097641 cggcttccga aaaagctgat cgtccatccg gctgaaccga gcggccgcgg tacgcgggta 1097701 tcacttgagt tgatgtaagg gaggagcgga tatggcaaag cagattgccg gaatatgtga 1097761 gctgtgcggc cggagcgatg tccagctgac agagcatcat cttacaccga aagaggaagg 1097821 cggaacgttt ttgccgacag cgatgctctg tattccttgt cataaacaga ttcatgcctt 1097881 atataccaat caagagctcg ctgtacgttt aaatggaatg gctgaactca gaagcgatcc 1097941 agagcttgcc cggtttgtca aatggatcag aaaacagccg cctgagaagc tgatcaaaac 1098001 taagaaatca aatgaacgaa aaaagaaaaa atgactaaaa agcagccctc tctttgcaga 1098061 gcggctgctt ttatccgttt ccaaccatat cctgatcgtt gacatcgggg tctatataat 1098121 ttgtcgcgtt gactgcatta tttaatagaa ggaaatctcc cgtgtttcct gctcccgaac 1098181 cgagcgcaga ttttgaagag cttttcggag aaaggtaaaa ggaatcacca aagtttacga 1098241 ctccgcccga tatggaattg atagctatag gcccgacaat tgctggcata aacgacaccc 1098301 tttatcgaag tctctgttta ttatatgttc ttggcgggcg attgtgagcg cggagactga 1098361 atctgtctga tatgtttgag tctcgcatca ccgcgaataa gcgaagctga tccggcatgt 1098421 aaaacagaag aggctgagac cccttgaatt ttgatgctgc gaacataaat agccggcacc 1098481 tcgtggcaaa acgcgctttg tacacctgtt tcggggagcg gcttcacggc ctgctgctga 1098541 aagatctgat actccttttt gttaaatgag ccttcattat ggtaaaacgt ggacagagaa 1098601 cgctgcacag caaatacttt tacactcata tcgatttcat ttgtgtcgcc aacttgaaac 1098661 acacttgcga tcccgagaga attaaactta actagtctga tgcgcgatat gcgtttaagc 1098721 attattctgg cgcaagcgga gcaaacggcc caataataag agattcaggc ggtgtatcaa 1098781 aaatagaaga caggtagatg gattcagtgt ctccgatgtg gaaaacggag gaactggaca 1098841 caccgttcat ccgaatatcc ccgacttcca agctgcggtt gatgactgta aagatcatgc 1098901 ttgctcatct cctttcattt ctgatggaat atgctccaga aagtgttcta cagcgcggat 1098961 gacatcacgc ttcacatgct cagcgatatg ttctgcatat tgtgcaggcg gtgtattttc 1099021 ttcttttttg atatgggaca tataatagtg aatcctgctg tccatttgtt ttctgatgtc 1099081 ttcaataaca tgatgtctgt ttgtatcgtc aagtctgctg tcatattgat tttcaagctg 1099141 ttccaaaata tctgggattt cctcggttaa gtacatgtcg acattctggc ggatctgctg 1099201 catgagctga gcgctctctt cctgctgcat catcccgatt tgcggtgtcg actggctgac 1099261 gtcaaagttt tggacgctgt tcgggtcagt cggatttaaa ccgatattca aagtcccgtc 1099321 gagcctttcg attttcagct gatcaaattt atactccaca cgctcaatgg tagtggccgg 1099381 ccgctgtttc atcgtattca tttcagtttg aatctctttc agctgacgtt cgagctgctg 1099441 aatgtgaatc gcctgctgct gaacgaagga attcaagttt tgcaggtaag aggaaacaga 1099501 ttgatcatac atgttcttca cctctttcat atgattaacg gccaggaggc tggagcggga 1099561 ccaatgaacc tgtgtcgggc tcctgcagct ggagcggttg ccctgagcca gaaacttctg 1099621 gtgccggctc tacatagctt cctgtattat acaaatttga cagtgacttg attgatccgg 1099681 cgctcccgat ttgcagaatg gaggagttgc tgattgattc cagccggaga tagttgattt 1099741 gaatggtttg attaatatag aagttcatga gcctcactcc ttttacgcat tggccacgat 1099801 cggctgatca accgcatcat tgtcatacac attcgtcgcg ttttgataat tcatcacctt 1099861 gaggctgtcg ccggtattaa agctgccagc accggcaaac gttctgacct gagcctgagg 1099921 agaaatcgta atgcagtccc cgatgtgaac gactccgctc gtaccaatcg cattaatttt 1099981 aaacgctccg acaatggccg gcatacgagc acatcctttg ttgaaaaatt aaaaaaagac 1100041 aggtaaagtg aaatgacaat tccgatttca attgggctat tcacgatagc ttatgacaaa 1100101 cgcacatatg tgtgagagaa attttaaggg gacatatcgg ctctttgtga aagcgtttta 1100161 ttttttcggg ccgttatgtt taaacatggc aaaagaggat gttgggtata aattgagcgg 1100221 aaatgcggcg aaggatgccg ctatccgcct atggtgattt ttgtttattt ctttggtgtt 1100281 tttgcgtgta gaatgctttt tggagtatgt cgtgctgcgg tattcgattt ttgggcgggc 1100341 acattctcgc cctgaggtat atctcagaag tgctgagcaa aaatcggagt taaatgtggt 1100401 gtattctaat tgttatagaa aatgatttac atacgggagt tttcaagata tctcccaaaa 1100461 atcatttctt ctttaatccg ggtattcagc aggatatcca gctcttggct gcattgaatc 1100521 gtttcttttg aattcatgcc gtatttttgt gcggtttcaa ttagtgtgat cctcatttct 1100581 tcaattttac tgttcattac gctatctcca attctagatt ttattttgat ataaatacag 1100641 gatatcgtta gtataaccta ttttggctca aaaggttgcc tttcgtcaat ttgactaaaa 1100701 aagcgacaat ttttgctgcg gcctttttta atggagaaag gactaaagtc ttgctaagtg 1100761 tgcttgcaaa aagtcctgcc gttcctcaat ttctctaagt atgttggtct gctccttttc 1100821 gatttgaaag gggctttttt tgataaaagg atcatcagca gcactttgac aaatgtcaag 1100881 gtgccattcg ttgatgagag gagataatcg ttcaatagta aacgaccgct tcagcacgtt 1100941 tttcattaag gtgtgatatt gcgacctgaa ggcgggaatg gatagaagcc ttgacgaaag 1101001 cgtctttcct tttgtcagaa gcgggtcttc ttcataccat tcttgtacgg caagcgatct 1101061 tgtctccatc ggggaaacgt aaagccgacc ggattcgttt aaacaaaatg tgtagtaaaa 1101121 gccttgattg gtgcaggtgt tgccgatcag ccacaaaaaa aacagcttga catccagata 1101181 caatttaatc ctttcagcca attcgtcatc tccggctgtg cggatcagta tgaaaaattc 1101241 atgtaagaat gccgaggaat cattgttaaa aagggacaat ggaacccttg gatcggccgt 1101301 cttcactccg taactccttt taccggctgg ctgatggttc ttgatgttca aataaatgcc 1101361 ttcaggctgg ccattgatgg tcagaaagct gtacgaggca acgggagcag gtacgccgat 1101421 ctggtcaaaa aaacaatagg cgagtctgcg ccgcatcagg gacggatcat cctgttctgc 1101481 attcaaaaaa agtgtccttt caccaagcag agacttttcc cagctgattt cataggatgc 1101541 cttttccgct ctgtcacgct gtgtgagaag aatgggagaa acagatcgat ctgttacgaa 1101601 aagccccttg gctgtacctt tccttttcag ctgctcccga tgaaaaaata aatgcacgcg 1101661 ctccatattc tttcctcctt ctcaaaacga catttgtatg atatgtagag caagcccgtc 1101721 ctgaaacgaa atgaaaacgg aattgagaaa aagggatttc agcattcgac agagaataca 1101781 tgaaggagca ttctgattta aaagatgatg gaggaataac atgaaatttg cgacagggga 1101841 actttacaac cgaatgtttg tcggcctgat cattgacgat gagaaaatta tggatttgca 1101901 gaaggctgaa aaaaaactgt ttgaacttga gacgattccg ggatcgctga ttgaatgtat 1101961 cgcagaaggg gataaattcg ttgcgcatgc aaggcagctg gccgagtggg caaagaaacc 1102021 gaatgatgag ctgggatcat ttatgtattc attatctgag gtgaagctcc atgcacccat 1102081 tccgaagcca tcaaaaaata tcatctgcat cggcaaaaac taccgggatc acgcgattga 1102141 aatggggagc gaggctgata ttccggagca tccgatggta tttacaaaat cgccggtaac 1102201 ggttacgggg catggtgata tcgtaaagag ccatgaagag gttacctctc agcttgatta 1102261 tgagggagaa cttgctgtcg tgatcggaaa aagcgggact cgcatttcaa aagaagatgc 1102321 atatgaccat gttttcggat atacgattgt gaatgatatc acggcgcgtg atctgcaaaa 1102381 aaggcataag cagtttttta tcggaaaaag cttggatacg acatgtccga tggggcccgt 1102441 gcttgtacat aaatcatcta ttcaggagcc agagcgcctc aaggttgaaa caagagtcaa 1102501 cggcgagctg cgccaatccg gttcggcaag cgatatgatc ttttccattc cggaattaat 1102561 tgaaaccctc tcaaagggga tgacgcttga agcgggcgac attattgcca ccggtacgcc 1102621 gtctggtgtc ggcaaggggt ttacgcctcc aaaattcttg cggtcaggtg acaaaattga 1102681 tattacaatt gatccgatcg gaacgctgtc aaaccaaatt ggctgaataa aactggaggg 1102741 cggacccgga cccgcccgtt ttttctgata atcatctttg tgacagagga caagttcatg 1102801 gtactataag tggggtaatt tatctgatag ggggaacata tatgacacac ctacatatta 1102861 cgacatgggt ggtagcgctg attctgcttt tcgtcagcta ctcgctgtat tcgtcaggaa 1102921 gtgcaaaggg cgcaaaaatc actcatatga ttctgcggtt attctatatc cttattattt 1102981 tgacaggagc tgagctgttt gtccgtttcg ccaactggaa cggagaatac gccggcaaaa 1103041 tgattctggg cattatcacc atcggcctga tggaaatgct cctcatccgc aagaaaaaag 1103101 aaaaatcaac aggaggcctg tgggtcggct tcgtcattgt ccttttgctg acagtgctgc 1103161 tcggtctgca tttgccaatt ggttttcaat tgttttaata gaaaaaccta tgaacccggc 1103221 tctttgatag agctggtttt ttttatattt atcccctcat attccaaatc atttaaaata 1103281 accttaaaat tccctgtaag cggtatctcg tcctatgaaa ttatgatacc ttcaaggaga 1103341 ttcattattt tgcaggaggg ataacatgaa acgcagaaaa ttcagctcgg ttgtggcggc 1103401 agtgcttatt tttgcactga ttttcagcct tttttctccg ggaaccaaag ctgcagcggc 1103461 cggcgcgatc gatcaggcgg ctgctctgga aaacggcaaa gagcagacag gcgccatgaa 1103521 ggagccggaa caggtgaaat ggtacaaagt gaccccggga gcaacggata ttcagaaaaa 1103581 ctcacatatg gcactgaccg taaagagtga ttcagtactg aatgtatctg tatatccaag 1103641 taaggaaaaa gcgcttaaag atgagacgtt tgagatgtac cgttctttca cagcggagga 1103701 tggaaaaagc gaagtcattt ttccatacgc gtggagcggc ccttactatg taaaagttga 1103761 atacctcgga gaagaagaac cagaggacgg cggaacggca gaagcagctg cagaagccaa 1103821 gtatacgatt gggtataaag gcaccaaaaa acagccgtca gatttagaag aggaagaagc 1103881 ttgtccggtt gaaatgagtg tcgatcagaa gaaatcagga aaaggcatcc tggataagtt 1103941 gagatcgatt cgtgatgagc agctgagcca aacagcagaa ggcaaagaac tgacaagcct 1104001 ttattacaaa gcagcaccgt ttatcgttgc aaagctcgca ctcaataaaa cagcaagaaa 1104061 tgaaatctat caggatcttg tgacattaaa gccgttattt gacgatgtgt cagaaaacgg 1104121 agcatcatct tcgtataagg tcactgaaaa ggatcaaaaa gcgatcaacc ggctatatga 1104181 taaagcttta caatcagtcc cgtcattcct taaagaggag ataaagaaac aagcggaccg 1104241 actaaatatg aagcagctgc aaggcaaaac agcaggagcc attttaacag aaaacaatat 1104301 tgcagcaaaa agtgaagttc agacaacaaa ggttattttc aaggtgaagg acaataaaag 1104361 cctctcatcc gtacataatg aaatgaaggg cttttctgca agcgcgcaat cgaaaaaaga 1104421 catatctaat gtgaaaaagg caaagaaact gtttgacaat ctgtattcat ttgaacttcc 1104481 gaaagacgag aaacagaacg gcgcatatac ggcaagcgcc aaaagggtca aaagcgctgc 1104541 tgcgacacta tccaagatgt ccaatgtaga gtttgcggaa cccgtacagg aatacaaaag 1104601 cttggcaaac gatattcagt acccttatca atggccgctt aaaaacaacg gtgaaaacgg 1104661 cggtgtcaaa aatgcggatg tgaaatatga gcctgccaac acattgctgt ccaaacgcaa 1104721 gcttaacgat acactcattg cagtagtaga cacaggcgta gacagcacgc ttgccgattt 1104781 aaaaggaaaa gtaagaacag atctcggaca caattttgtc ggacgaaata acaatgcaat 1104841 ggatgatcag gggcatggga cgcatgtcgc aggcattatt gcagcccaaa gcgataacgg 1104901 ctattcaatg actggattga atgccaaagc aaaaatcatc cctgtaaaag tgcttgattc 1104961 cgcaggttcc ggagatactg aacaaattgc tctcggcatc aaatatgctg ctgacaaagg 1105021 agcaaaggtg attaatttaa gtttaggcgg aggctacagc cgcgtgcttg aatttgcttt 1105081 gaagtacgca gctgacaaaa atgtcttgat tgccgcagcc agcgggaatg atggagaaaa 1105141 tgccttatct tatcctgcat cttctaaata tgtgatgtca gtcggcgcaa cgaatcgcat 1105201 ggatatgacc gctgatttct ctaactatgg aaaaggtctg gacatctctg ctccagggtc 1105261 tgatatcccg agcttagtgc cgaacggaaa tgtcacgtac atgagcggaa cgtctatggc 1105321 gacgccatat gctgccgccg ctgcgggact gctgtttgct caaaatccta agctaaaaag 1105381 aacagaagtt gaggatatgt tgaaaaagac ggcagatgat atttcctttg aaagtgtcga 1105441 tggcggagaa gaagagttgt atgacgatta tggcgatccg attgaaattc cgaagacacc 1105501 tggtgtagac tggcattcag gctacgggcg gctgaatgtc atgaaggctg tcagcgcagc 1105561 tgatttacag cttaaggtca acaagctgga aagcactcaa acagctgtca gaggaagcgc 1105621 gaaggaaggc acccttatcg aggtgatgaa cggcaaaaag aaactcggca gcgccaaagc 1105681 cggaaaagac aatgcgttca aggtgaatat cgcgactcaa aaacaggatc aagtactgta 1105741 tctgaaagca acaaaaggcg atgcgaaaac atcgtataaa gttgttgtcg tcaaaggaaa 1105801 accttccggc acaccgaaag taaacgcggt gaaaacgaag gatacggcag taaaagggaa 1105861 ggcaaacagc aaagcgatga tcagagtgaa aaacaaatca aagaaagtca ttgcttctgc 1105921 caaagctgac gcaaaaggaa cgttttcggt gaaaatcaaa aaacaaaaag ccggaacggt 1105981 gctgtacgtc acggctgtgg atacagataa aaaagaaagc aaggaagcaa aagttgttgt 1106041 tgaaaagtaa ccaaaaagcg gtgctcgatg caccgctttt ttatttgcgc ccccgttgga 1106101 ctgctgtgta cataatggat cgctttccgt ttgaagccgt ccattcaaaa cggtctcctg 1106161 tcccttcgct gctgtagttg tagtgatgct gcatcgcgca ttgtgcggtg tcatttgaaa 1106221 agtgataaaa ggacacaccc tgccccgccg aagtattcga aaagactcct ttattataag 1106281 aaaagacgca atcgaatacc gataagccga agctgtgcaa gtgctgcaga aatgcgagaa 1106341 aggtttcgtc gtcaagcgaa tccaaaagcg ccatgagcgg ccgcttgact gatttctcat 1106401 agcggatgcg ttctccgccg gaaagggaga tgttttctgc accgcatgcc aaaaccaact 1106461 tgtcctgaaa gccggcttgc tcccactttc ctttatgatg gatccagatt gggctgtgtt 1106521 ggagactgtc cgccagcagt atatcgcctt caccgttttc gattaagcag atgccgtctt 1106581 caatgaggat ggtgccgtat tcccactttc gttcctctgt atataacaat tgtttccgtt 1106641 tcatccatgc tgtctccttt ttcttcattc ctctcttttc tttccaattc aagcctgtcc 1106701 catacaactc ttttatggac aaatcaacta tctgcctata gatgcataaa cttactaagg 1106761 tgctgaaaga aacgaaattg ttacgaaaga aacgggattg gagctgatgt cacatgtgtg 1106821 gaattacggg ttgggtcgat tttaaaaagc agctcgtcca ggaaaaacaa acgatggaca 1106881 gaatgacaga cactctttcc aaacgagggc ctgatgattc aaacgtttgg ggggagcacc 1106941 atgttttatt cggacataaa agacttgcgg ttgttgatat tgaaggcgga cgccagccga 1107001 tggcgtgtac ctataaaggc gatacgtaca ccattattta caatggcgag ctttataaca 1107061 cggaagattt gcgcaaagaa ttgcgggcgc ggggccatca attcgagcgt acgtcagata 1107121 ccgaggtgct tctgcacagc tacatcgagt ggcaggaaga ctgtgtcgac catctcaatg 1107181 gcatattcgc tttcgctgtg tgggatgaaa agcgtaatct gttgtttgcc gcgagagacc 1107241 gtctcggtgt aaagccgttt ttttacacga aggaaggctc ttcatttctc ttcgggtcgg 1107301 aaatcaaagc aatcctcgcg caccctgata taaaagcgcg agtggacaga acgggacttt 1107361 ctgaaatttt cggtcttgga ccgtccagaa ccccgggcac tggcatattt aaaggcataa 1107421 aagaaatccg cccggctcac gcgctgacat tttccaaaga cggacttaat atttggcgtt 1107481 attggaatgt tgaaagcgaa aaacatacgg acagttttga tgacacggtt gccaatgtca 1107541 gatcgttatt tcaggacgcg gtgacgcggc agcttgtgtc ggatgtgcct gtttgcacat 1107601 tcctatcagg cggtctggac tcaagcgcga ttacagcgat tgcggcgggc cattttgaaa 1107661 aggaaggaaa agcaccgctt catacttatt cgattgatta cgaagagaac gataaatatt 1107721 ttcaagcaag cgcttttcag ccgaatgatg acggaccatg gattgaaaaa atgacagagg 1107781 ctttcggcac aacgcaccac aaatgcgtca tcagccaaaa agacctcgtt gatcatttgg 1107841 aggaagctgt actggtcaaa gacttgccgg gaatggcaga tgtcgactca tccctgctgt 1107901 ggttttgccg ggaaatcaaa aaggactttg tcgtcagcct atcgggagaa tgcgcggatg 1107961 agattttcgg cgggtacccg tggttccata cggcagatgt tgagtctggc tttccatgga 1108021 tgagatcaac ggaggagcgg atcaagctgc tttctgactc atggcagaaa aaattgaatc 1108081 tgaaagaata cgtaaatgcc aaatatgaag aaaccttggc agaaacgcca ttattagacg 1108141 gagaaacggg tgtggataaa gcaagaagac agctgttcta tttaaatatg ctttggttta 1108201 tgacgaacct tttggatcgg aaggatcgca tgagcatggg ggcgagcctg gaagtgcggg 1108261 tgccgttcgc cgatcaccgg cttgtggaat atgtttggaa tattccgtgg gaaatgaaaa 1108321 tgcatgataa tcgggaaaaa ggcattttgc gcaaagcgct tgagggcatt ttgcctgatg 1108381 acattttgta tcgcaaaaaa agcccatatc cgaaaacaca tcatccggaa tatacaaaag 1108441 gcgtcagcga gtggctgaaa acgatcagaa gccaaaagga ctccgtgctc cataccttac 1108501 tggacagaaa acaattagat cagcttttag aaacggaagg ctcctccttc aaggtcccgt 1108561 ggttcgggca gctcatgaag gggcctcagc tgatcgccca tcttgctcaa attcatacat 1108621 ggtttgaagc gtatcgcatt gatattgacg agaggtaggt tcaatacaaa tgtgattaaa 1108681 agccagagat gtatagattt aaataagaag gatagatgag cagggaaata tatgctctat 1108741 ctatcctttt ttgtacaaca gcactatcga attgcccccg cattccttca ataagaatga 1108801 ataggtttta atgttctgcc gataaaacta gctgataccg ggcttaactt taattcccta 1108861 gcccatacag aaagttgacc aatatggtga atttcgtgag cgatgatatg gtgtaatatt 1108921 tcatctcgcg tatataaaac acctgtctcc caaggaacgc ttacaagttc atcttttatt 1108981 tgatctgaat gtgtttgtaa aacatcaatt atttcagttc ggaatgtatt tgagagagat 1109041 ttcactttat tgagtgtttg ataatcagcg aactgaacag cgatatcttc ttttccttgg 1109101 atagcacgaa tccaactata ttccacatca ataatatgaa aaagggtata taaaatattc 1109161 tctactccgc caagacgatt tttaagtaat tcttcagtgg ttagttgatg acaccaagta 1109221 aaccattgat ctctaacctg ccagttatat tcaaaaaatt tcatcactaa actcactcca 1109281 atactatcat gtatcataac aattagccct tttttccgtg attcctctat taatgaagtg 1109341 atgattgaga aatgtttaca ttctacctgt tgtatggcat taaaaataat aatgcatatc 1109401 tcgtcgatga tgctgtgcgt cttgttactt ttacaaagta agaatcggca ttttcttcat 1109461 atacaattag gaaaaaacat actagacttg aagaagcagt gatacatagg agtgagaaaa 1109521 tgaaagagat aaaagaagct taccagcaat gcggacagat tgttggcgaa tacgcgccag 1109581 cctgtttcaa agcattatca tatctcccgc taaagcaaag acaagcctct tgggcagtat 1109641 tgtcgttttg ccacacggcg gccagtgcag acgaaaaggt attgcccgca tttgaagcta 1109701 aagctgatca tgtttaccaa aggacaaata acggtaaaca acatctatgg aaggcttttg 1109761 atcatgcgta tcggaccttt acattggaaa gcgaaccttt tcgggagttt attgccgcac 1109821 aaaaagaaga cgccaagccg tatgatgacc ttgatgaact gctcatgtac gcatatcgga 1109881 cgggcggtgc tgccggattg atgctgctgc cgatactgac acgccgaaaa caagatcagc 1109941 tcaaacaagc agccgtctct ctcggcttgg ccatacagct ggttcgcttc ttaagtgatc 1110001 ttggcacaga tcagcaaaaa aaccgcattc cccgtcaggt aatgcagcaa ttcggctata 1110061 cagaggctga tctccaaaaa ggcaccgtaa ataaagcgtt cacaatgacg tgggagtata 1110121 tcgcttttga agcagaagcc taccttgaag agtgtcagga tgccttgccg ctatttccgc 1110181 agtattctca aaaaacggtg aaagccgctc ttcatttgca ccgggctgtt ttagaaaaaa 1110241 tccgggcgaa gcagcacgat gtatttcaat atcacttcgc tctcacagag accgaagtga 1110301 agcagattct gtctgatatc taaaaaacac ccggccttga ttgagccggg tgttacgcca 1110361 tacctttttg aatccagata cgtgagcgcc atcttctgta cattaagatt ccccggaccc 1110421 attcatccgc gataaaagaa atccaaatgc cggcaagacc gaaaccgagg tggatgccga 1110481 aaagataagc aagcgggagg ccaatgcccc acattgaaat cattgccatg taaaccggga 1110541 atttcgcatc ccccgcggcc cgcagagagt taatgataat gacattaaac gagcggcctg 1110601 gttcaaggat aatggtcatg gcaatcaata ggcttgcagt tgctataatg tcagggcttt 1110661 gtgtgaagag tccgatcagg tcttttgaaa agatcgtcat caaaacagag gtagccgcag 1110721 caattccgag tgcccaatat aagctcttca tgcagcgctc ataagcggca tcaaattgtt 1110781 tgccgccgat ataacggccg attaagattt gtgtaccctg gctgatcgca gtgccgaaca 1110841 gcaaaataaa catcgtaata ttttgcgtat acacttttgt tgtcaacgcc tgcgcgccca 1110901 tgatggcgat aaaatacgtg actatcattt gcgacaggtt gtatgaaagc tgctctcccg 1110961 cagaaggaat gccgattttc agcagcttgc gcaaatgctc tttatgcata tgaaagactt 1111021 ttttcagcga catcttcagc tggatgcgtt tgttgacaat cacaatcatc gcgattaatc 1111081 cgatgacgcg ggcgatagat gtggacatgg ccacaccggc aacaccgaga acaggaaagc 1111141 cgaacaaacc gaaaatcaca acaaagtttc cggcaatgtt taaaatgttc atgccgatag 1111201 tgacaaacat tgtatctttt gtgtagccgt agctttttaa gatcgcgctg aatgtcatga 1111261 ttaaagcctg aataaaggac agacctccga caacttgtaa aaagactttc gcatcaggca 1111321 tcagtgcgtc tgataatccc atcatatgaa gcagagggac agccgcgaaa aagacgacgg 1111381 cgctgatggc caggctgatg aagaagttgg cgccgattga cacataagcg acttccatgg 1111441 cttctttctt ttgccgtgag cctagaaatt gtgaaatgat aacggtcgtt cctgttgcga 1111501 taaagctgaa catcacgata attaaattta aaatctggtt gctgacgccg actgctgcca 1111561 cgctgttatc cgagtattgg ctgagcatca gtgtatcggc attacccata aacatatata 1111621 atgagacctc aataaagatc ggccaagtaa gcgaaaataa tgagaacgtt ttgtcagcgg 1111681 gttttttcaa agcagttgat ttgaagacag cttgtttcat cgtgtctaac ccctttcgta 1111741 aataaaatca acgttttaaa gtgtacctcc atttccttat aataaaaagg gatagaaacg 1111801 atacttcttg taaaaatccg acttaaaaag gaggatgatt caaatgcctc gcatcctgtt 1111861 tacagtcccg ccttttccgg tatttatcgc agctggggaa ggggttttta aaaaaggaga 1111921 aacccatgtg aaacgtgtat tctccgtgtt tgatctgata tatgtcaaac agggaacgtt 1111981 atatataacg gaaaatgaaa catcgttttc tgttgaaggc ggcgagtaca tcttgctttc 1112041 tcccggtctt gaacactacg ggacgaaggg cagtgatgaa gcaacctcct actattggct 1112101 tcacttcgat gaacatcgat atgaatttac ggcaaaggga ggcagcaact ggtctgagct 1112161 tcagcaggaa aaagggagct tcgaagagct ggcccgctac ggattggcct tgccgagaaa 1112221 aggcaaggtg cagcgcccgc agtttatggc gcagcagttt gaaaagctga tcgattactc 1112281 cgcggaaaac tctgatttgc cgctcagaaa gcaaatttta tttgaggagc tgatgctgca 1112341 tcttcaaaaa gaagcgttcc aaataccgtc tgcgaaagag cgggtagcct gggaggcggc 1112401 ccggtattta caggagcact ataaggaaaa gacgacaatc aaggatctgt cgctcgccct 1112461 tcactatcat caggattatg tgagccgctg catgcagcag gtgctcggcg taactccggc 1112521 acaatacacg aaccgggtga gaatgacgga agcgaagcgt cttttatcct ctacaaatga 1112581 taaaatgggc gttattgcgg aaacggtcgg aatggaagat ccgacatact tttcaaaact 1112641 ctttaagcag atagaaggca tttcaccaat tgaataccgg aaaattgtca gccggaaagt 1112701 tcaataacca gacgagggat gaacatgaaa acaacaattt acgatgtggc aaaggcggcg 1112761 ggtgtttcga tcacaactgt gtcccgtgtg ataaacaata cggggagaat cagcgataaa 1112821 acacggcaga aggtcatgaa tgtcatgaat gaaatggcat acacgcccaa tgtccacgcc 1112881 gcggcgttaa cgggaaaacg aacgaatatg atcgctctcg tggcgcctga tatttcaaat 1112941 ccgttttacg gcgaactggc caaaagcatt gaggaaagag cggatgagct cggttttcaa 1113001 atgttgattt gcagcaccga ttacgatccg aaaaaagaaa caaagtattt ttctgtgctg 1113061 aaacagaaaa aggtggatgg cattattttt gcaacaggga ttgaaagcca tgacagtatg 1113121 tctgctttgg aggaaatcgc cagtgaacaa attccgattg ccatgatttc tcaggataag 1113181 ccgcttcttc cgatggatat tgttgtgata gacgacgttc gtggcggata tgaggctgcc 1113241 aagcatcttc tgtcactcgg ccacacgaac atcgcctgca ttatcggaga cgggtcaacg 1113301 acaggcgaaa aaaatagaat caaaggcttc cgtcaggcga tggaggaagc gggcgtgccc 1113361 attgatgaat cacttatcat ccagacgcgg ttttccttgg aaagcggcaa ggaagaagcg 1113421 ggaaaattgc tcgacagaaa tgctccgact gctatttttg ccttcaacga cgtattggct 1113481 tgtgccgcca tacaagctgc gagaataaga ggcataaaag tgccggatga tctttctatc 1113541 attggttttg ataatacgat actcgcagaa atggcggctc cgcccctgac aaccgtagcc 1113601 cagccgataa aagagatggg gcggagcgtc atcgaactgc tggcagaagc aatagaggga 1113661 aaacgaaagg cgaaacaaaa aatagtgctc ccgcctgagc ttgtagtcag acattctaca 1113721 tcaccgctca acacatgagc ccgctaatga gcgggttttt tcattatgac agttgaagcc 1113781 aaaaaaacat attgcgtgta aaccaaaggc ggtgtaaaat ataaccatct tttgagaaag 1113841 cgcttgcgca aaatggcaga gcggatagaa ccgctgtttt tttagctgtt aagagaaaac 1113901 gctttctcaa agcgagcccg aaatgagata aaggagagga tgggacgtgg aacatcaagt 1113961 aagatgtgca gtattgggat taggaaggct cggttattat catgcgaaaa atctcgtcac 1114021 cagtgtgccg ggggcaaagc tggtttgtgt cggtgatccg ttaaaaggga gagcggagca 1114081 ggttgccaga gaactcggta tcgaaaaatg gtcagaggac ccgtatgaag tgttagaaga 1114141 tcccggcatt gatgctgtca ttatcgtaac gccgacaagc acacatggtg atatgatcat 1114201 caaagcagcc gagaacggca aacagatctt tgttgaaaaa ccgctgacat taagccttga 1114261 ggaatcaaaa gcagcttctg aaaaagttaa ggagacaggt gtcatctgcc aagtcggctt 1114321 tatgagacgg ttcgatcccg catacgcaga tgccaaacgg cggatcgacg ctggagaaat 1114381 cggcaaacct atctattata aaggctttac gcgcgaccaa ggcgcgcctc ccgcagaatt 1114441 tatcaaacac agcggtggaa tttttatcga ctgttccatc catgactatg atattgcccg 1114501 ttatttgcta ggggcggaaa tcacttctgt ttcaggacac ggcaggattc tgaacaatcc 1114561 gtttatggag cagtatggcg atgtggatca ggcgctgacg tatattgaat ttgactcggg 1114621 cgcagcgggg gacgtcgagg caagcagaac ctctccatac ggacatgaca tccgggcgga 1114681 ggtgatcggg acagagggca gtattttcat agggacattg agacatcaac atgtgaccat 1114741 cctatcggct aaagggagca gttttgatat cattccagac tttcaaactc gttttcatga 1114801 agcctactgc ttggagcttc agcatttcgc cgagtgtgtc cggaatggaa aaacaccgat 1114861 tgtgactgat attgatgcga cgatcaattt agaagtgggt atcgccgcaa ccaattcctt 1114921 tcgaaacggc atgccggtac agctagatgt gaagcgcgct tatacaggta tgtaaaagct 1114981 aagtatgttg catttgaggc tttccgcaaa aaaagcaagg gcattttagc ccttgctttc 1115041 tcttttctca tataaatagt acatataatc agtaggtacg cctgaatggt ccagctgtct 1115101 cagcatggcg gttacgttcc ctctgtggta agtgccgtga ttgacgacat gcaggatggt 1115161 gtctgcatag gttgattcca gtgtacctag tttcggatgc tgcattgtga aggtctgttc 1115221 taagtccgtc tggcggctga agaaatcatg atactgtgac tccagctcgg cagcgtgctg 1115281 tttaatcgct gccatattac cttgcgcgga ctgtaatttg cctgcgctgt ctataatctc 1115341 ttggtaggcc actcccgaaa gaacattcag ccaaatgtag tcagccctgc acatatgaag 1115401 cagcacgtcg ctgacagaag gaaatacgct ctttacttct tgataggcag tttcctccgg 1115461 caggttttcg atatgggtaa atattttctt gtttgcccaa gaatgatagt cataaaactg 1115521 ttttgcatca gtcatcagca tgcccccttt tctaagaaat tcgttttttt catctgtttc 1115581 tccttcaatt gcaaaagagt gacaccccaa aatatcctgc cgctgcccac attaccgctg 1115641 cagagcattt gtttacgatc agcataagcc tgccgctcgt atctatcgtc tgaaacaacc 1115701 ggcccgctat tgcaaggctg atgaaccaaa tccaagacac agcgatgcag gcggccataa 1115761 agagccattt ctcaagcccc gaatattgaa gagagctcgt gccgatgacg ccgatcgtgt 1115821 ccagaatggc atgcgggttt aaaagagaaa cagcggccgc aaacgcagct tgcttttttg 1115881 gtgtgaacgt atgtttctca ttttggcttg tgttcggacg gatgttccaa gtcacccagc 1115941 ccatataaag caaaaataaa aatccgccgg ccatcatgac tgtctcaaac acaggcagct 1116001 cctgcacaat gacagacacg cccgcaacgg ctaatacaat taacaaggta tcgcagactg 1116061 aagcactgat gacagctggg agagcccgcc aaatatgctt ttgcaacgcg ccttgctgaa 1116121 aaataaacac attctgcact cccagcggca aaattaagcc aaacgcgagc acaattccgt 1116181 gaatgattgc attcatgctg aaaaagctcc tttcacattt tttttcaatc ataagagaga 1116241 ttgtcactaa agtctccagc catttggttg ggttaggaac cagccaaatg tataatgtgt 1116301 aaaaaagggg ggcatgacct tgtcgcaatg gcagccaagc cgaaagtcgg atgttccgct 1116361 gcatcggcag atcgaacaat atatgaaaga caagattctt cacggagagt gggctgtagg 1116421 gacgaaaatc ccctcacaga gaacgctggc cgacatgttt caagtcaacc gcagcacagt 1116481 cacagcagcc atagatgaac tcacgtctca aggcttgtta gagggaagaa aaggcggcgg 1116541 tacgaaggtt gtaaacagta cttggagcgt gctgacggct gagcctccgc ttgattggag 1116601 cgattacgtc cgttcgggca ttcatcgcgc caattcttcc atcattcaag ctattaatca 1116661 gaacgaacca agagcggata tcatcagatt aggaactgga gaactttcac cggatcttgt 1116721 gcctgctgac acaattggac ggatgtttca gcaaatcaat ccgggcgtcc tgtctttagg 1116781 atatgagcag ccgaaaggaa accgtcagct gcgggaggca gtggccgacc atttaaaagg 1116841 aaagaagatc catgtgtcac cgtctgcaat tttaattgtg tccggtgcac ttcaggcact 1116901 tcagctcatc tcaattggac ttttaaaacg agattctgtc attttgacgg agaagccgtc 1116961 ctaccttcaa tccttgcatg tatttcaatc agctgggatg cggcttcgcg gcttgccgat 1117021 ggatgatgaa ggggtcaaag cggggcttgt ttcttctaat cgaaaacaat atggaggaca 1117081 gctgctttac acgattccgt cgtttcataa tccgacaggc acagtcatgt cagagcagcg 1117141 aaggaaagag atcatcagcc tgtcaaaaaa agagcagatg cccatcattg aggatgatgc 1117201 gtacggtgat ttatggtttg aagaaaaacc gccgcagccg ttgaaagcaa tggatcatga 1117261 gggcaatatt ctgtatctgg gcgcgttttc aaaaacggtt agccccggtc tgcgaatcgg 1117321 ctggcttgcc ggtccggagc cggttattga aaggctggcg gacattaaaa tgcagacaga 1117381 ctacggatca agcggcctgt cccagtgggc ggctgccgag tggctgtcac agggatatta 1117441 tgaagagcat ctgacttggg tacgcaggaa gcttaaagaa aggagagacg ccgccgttca 1117501 ttttctcgag cggtatgccg gggacattgc cacgtggcgg attcccgcag gcggctttta 1117561 tatttgggtg acatttcaca aaaacctgcc tgtcagccgt ttcttttatg aattgctgaa 1117621 acggcaggtg cttgtgaatc ccggctatat ttatgacggt gaagaccgaa acagcatcag 1117681 gctgtcatat tcctatgcat ctcttggaga tttggaaact ggcattaaag cggcagctga 1117741 aacagcacgc cgcctgatga tgtcctaggc tttggttata cgatgacagc tcccagtgcc 1117801 ctggcgaagg caatcgcgtg ctcaggtgcg attttgcagc ctttcaattt gtcgagggag 1117861 acatgaagct gttcaaaacg gcacgtgctg atgtccatgt tttgaaggga cgtgccggta 1117921 aagctggcgc cttccaattc gcatccgtca aagtgtgtct gctggagcac cgtatcgctg 1117981 cattcacttt gcataagagc acagtgatca aatcgaactt gtttcatatt tgagtacgaa 1118041 aatgagctga aatgtccgtg gcattcctcg aatgaaacat tccgcagcgt tgcttccgcc 1118101 acattcattc caaccatttt tgactgctta actgaagttc tgtgaatgac agccccgctg 1118161 aaatcggcgt ttgataaatc gcatttttca aagatcacat cggtcagttc aatatgccga 1118221 aaagacacat cgataaagac gacatttctg aataccgttt tttcaacaca tagtctttcg 1118281 atatcttcgc cgcagatggt gcaatcttca aacaaatgca tgctgattac atcatcctgt 1118341 gtcacggcat catgaaaatc tgcggtttgc aggttttccg gtatgttcgg tttttgaatt 1118401 gcgattttat tcatgtgatg acatcctttg ctgcccgaaa aacagaggct tccgggttca 1118461 atttaataga tcgttaagga aattgataca tatagtaaat cgtgaagagc cttttcttgg 1118521 tacagcagcc cgcttgtttt gtaagcataa atggaaagct tcctatacgt caaggcgttt 1118581 acaggccgaa aaagccaaag ggaacaggag gaatgcggaa tggggcatta catcaaaacc 1118641 gaggagcatg tgacactgtt tgtagaggat atcggacatg gaaggccgat catctttttg 1118701 cacgggtggc cgttgaatca taagatgttt gaatatcaaa tgaatgagct tccgaaaagg 1118761 ggatttcgtt ttatcggcgt tgatttgcgg ggatatgggc aatctgaccg cccttgggaa 1118821 ggctacgatt atgacacgat ggccgatgat gtgaaagcag tcatttatac gctgcagctt 1118881 gagaatgcga ttcttgccgg tttttcaatg ggcggcgcaa ttgcaatccg ttatatggca 1118941 aggcatgaag gagccgatgt tgataagctg attttactgt ctgcggcggc ccccgcgttt 1119001 acaaaacgcc cgggttatcc gtacgggatg aggaagcagg atattgacga tatgattgaa 1119061 ttgttcaaag ctgatcggcc caaaacactg gctgatttag ggaaacagtt ttttgagaaa 1119121 aaagtgtctc cagagcttag gcagtggttt ctcaatctga tgctggaggc ttcctcctac 1119181 gggacgatcc actcgggcat cgcattaaga gacgaagatc tcagaaagga acttgctgca 1119241 atcaaggtgc cgacgctgat cctgcacggg agaaaggata gaattgcgcc gtttgatttt 1119301 gcgaaagaat tgaagcgcgg catcaaacag tcggaattgg ttccgtttgc aaacagcggg 1119361 cacggagcat tttatgagga aaaagagaag atcaacagtt tgattgcgca gttctccaac 1119421 tcataagaaa aaacccgaca ttgatcgggt tttttatata attcctctgt tttgcagtgc 1119481 gttaatgatg agatcagctc catcggaaat agaggtctgg tcagactcaa tgatgaaatc 1119541 gggtgaaagc ggcgcttcat acggagaatc gatcccggtg aaatgtttga tctctccgtt 1119601 tcgcgctttt ttataaagcc cttttggatc gcgctgttca caaacatgca gcgggcactt 1119661 cacataaatt tcgaagaact cacctttagg aaagagcgct ctaaccatgt cccgatcctc 1119721 tctgaatgga gaaataaaag ccgttaaaat catttgcccg ctgtcgacaa acagcttcgc 1119781 cacttctccg atccggcgga tgttttcaat cctgtcacca gtctgaaatc caagatcttt 1119841 gtttaagccg tggcggatat tatcaccgtc aagcacgtag ctctgaatgc ccttgcggta 1119901 aagcttttca tcgacagcat tggccagcac cgattttccg gagccggaca aacctgtaaa 1119961 ccaaaggacg cagcttttgt gtccgtttaa ggactgtctg tcagactttg agatggcagc 1120021 gggatgccaa atgatgttcg gattgtgtgt cattgcaatt ccccgctgtt ttgcttgatg 1120081 gcaacaggct gttggtgaag tcccttgatc agcacggctg cgacctcagg ccggctgaat 1120141 tctttaggcg gctttttgcc ttggcggaga agctctctca cttttgtgcc tgataagtgg 1120201 atgtggtctc tcgggctgtg cggacatgtt ttggaggtgc ccatgtttcc gcattttcgg 1120261 caataaaagc tgtgctcaaa aaacagcggc ttgatgccca gctcttcctc tgtgaatgat 1120321 tgaaaaatat tttgggcgtc gtatgttcca tagtagctgc cgacacccgc gtgatcacgg 1120381 cctacaataa aatgggtaca gccgtaattt tttcggacga gcgcatggaa aatcgcttcc 1120441 cgcggacctg cataacgcat ggcggcaggg aaaaccgata acatgacacg atcctttgga 1120501 taatagtgat taagcaaagc ctggtagctc tccattctga tatcgctggg gatatcgtct 1120561 gactttgttt ctccgacaag tgggtgaagc agcagaccgt cgaccgtttc taacgctgtt 1120621 ttttgaatgt attcatgcgc tctgtgaaca gggttcctgg tttgaaagcc gacaatcgtc 1120681 ttccagccga gtttttgaaa ggccgctctt gtttcagcgg gcgttgcata aaactgttcg 1120741 aaagatttgt caggcaggct gctgaccgtg ataggccctc cgatatagta atccgggcgc 1120801 gccagcaatt tttttacgcc tgggtgggca ggatcgtttg ttttaaaaac agacagtgct 1120861 tcttgtgttt tatcaggctg gtatatatcg gtgactgtga tcatgccgta ggtaacaccg 1120921 tctttcacaa gcttgacgtg atctccggca gacagctgtc ttgctgtttt ttctccgaca 1120981 ggcagcgtaa tcggcaggct ccacggcaag ccgtttgcca gcctcatctc tttcacaacg 1121041 gaatgataat ctttttctcc caaaaaacct gttaacgggc tgtagccgcc gatcgcaata 1121101 agctccagat cactcagtgc aagctgatcc agctctgctt ggcacgcgca cccttcaaaa 1121161 tggcatgcgg gatcacagcg gttgattaat acccctccgt ggggttcgtt tccattcaac 1121221 gtgttcaacc tccatttata cgtttccttg ttttcttttc tgcacttaat gaaagtttga 1121281 catcagcgcc ttaacatcat ttcgattctc acatcaagaa cctgccatcc gctattcttg 1121341 atgcaggccg cattctgttt tctcccgtcc ggcccatctt ccagccctct catcgttcgg 1121401 gtccggggaa ggcagtgtac acatttcaca gcctatgctc ggataatgtt gatcgtgcag 1121461 tttgttataa ggcaaattgt gcaggcggat gtacgtccaa acgtcatccc atgtccagtg 1121521 gataagcggg caaattttga tgagctcaaa cttctggtcc aggtttacgt attgaatatg 1121581 ctttctcgtt ggtgactgat cccggcgcag tcctgaaatc caagctgtca tgccggacag 1121641 gtgctttttg agcggttcga ttttccgcaa ttggcagcag aggttcgggt tatgcttcca 1121701 cagctctccg ccgtacttcg tcccctgttc tgttaagctc agctcgggtt cgagcatctg 1121761 gattgcaaat cccggatatc gttctttgac ggtctcgatc agctcatatg tttcctgaaa 1121821 atgaagcccg gtatccaaaa agatgatgtg tgcgtttttg ttgatttttg atattaagtc 1121881 gagaagcacc attccttctg cgccaaagct gcaggcgtac acaatctttt ctccgtacgt 1121941 tcggtaagcc catttcaaca catcgagctc atcgatcaat tgatccgtta tctgtttgga 1122001 cagcatgtcg ttccaagtgt catatgtgat ggtttcgttc aatgttttcc ccccgtttgc 1122061 atctgctttt tttatctatt gatcgagtta taggcagact attcattttt tgcataaagg 1122121 ttcaggtttt aggtgccgcg cccgcctaaa atgaggtgcg gaaccattaa gagcccggct 1122181 gaatatgctt tttagcaaaa tggttttatg cccaaggaga ggtagtatgc cgattgccat 1122241 ttatcagggg catcatcatt cgcttgcccc ggcggacatt aacatcgtca ttgatgtcat 1122301 cagagccttt acggtcgccc attatgcgtt tatcggcggg gcgaaagaga ttttgttggt 1122361 ccggacagct gatgaagcct ttgcgctgaa agacacctat ccggattatg ttttgacggg 1122421 agaggaaaag ggggtcggta tcagcggatt tgatttagat aattctccaa aacgtatggc 1122481 tgggcagaat atgacggata aaagcctgat ccagaaaaca acaaacggcg tcacagcagc 1122541 attgggggcg ctgaacgcaa agcatctgtt cgtaactgga ttttccaatg ccaaaacaac 1122601 ggcacagcat gtgaaaaagc tcgtcgcaaa cgattgtgtc ataaacatag tggcttccca 1122661 tccatccggt gatgacgata tggcatgtgc ggagtatatc aaaggcatca ttgaagggac 1122721 aaatgtggta acggctgcgg aggcgattga aagaataaaa ggctcttctg ttgcggagaa 1122781 gttttttgac tgccgccagc cattgtttga ttcggaagac atcgtttact gtacaaaaga 1122841 actgacgggc gatttcgtga tgaaagtgaa acaagatgga gaagttccaa cgatagagag 1122901 ggtcataata tgaatgattt ttcactagaa ttgccagtga gaacaaacaa gccgagagaa 1122961 accgggcagt ccattttaat tgataacggc tatcccttgc aatttttcaa agatgcgata 1123021 gccggagcgt ccgactatat tgattttgtg aaattcggct ggggcacatc attacttacg 1123081 aaagatcttg aagaaaaaat cagcacactg aaagaacatg acattacatt tttctttggc 1123141 ggcacactgt ttgaaaagta cgtaagccag aaaaaagtga atgaatttca tcggtactgc 1123201 acctatttcg gctgtgaata tattgagatt tcaaacggta cgctcccgat gacaaataaa 1123261 gagaaagcgg cttacattgc cgatttttct gatgaatttc ttgtgctcag tgaggtgggc 1123321 agcaaggatg cggaattagc aagccggcaa agctctgagg aatggcttga atatatcgtt 1123381 gaggatatgg aagcgggcgc ggaaaaagtg attacagaag ccagagaaag cggaacggga 1123441 gggatctgtt ccagcagcgg cgatgtcagg tttcaaattg ttgacgacat catttcctcg 1123501 gatattgata tcaacaggct gatttttgaa gcgcctaaca aaacgcttca gcaagggttt 1123561 attcaaaaaa tcgggccgaa tgtgaatctt gccaatattc catttcatga tgccatcgcg 1123621 ttggaaacgc tgcgtttagg gctaagatcc gatacctttt ttctgtaaaa tagcggctgc 1123681 ggggctctcg tcgtgaagag agcctctgcc tattattttt tatggcggta cataggcgtg 1123741 agatagggaa gtgaggtcag gcggatgttg tagatgaagt cgatgactct tgtcgatatc 1123801 acctggcata tgagggcttg aatgacgatg ccccagtcaa taatagacgc ggtgaccata 1123861 aaaatgatgc aattcatgat gagcaggatc gttccaggat tcccgccgcg gtagatagaa 1123921 atcatcagag caagggctcc gaatcctccg ttcgaaattt tatatttgta taaaagtccg 1123981 attccgagtc ccaataacac tgcgccgctt gccagatcaa gccacaggtt agatgtgata 1124041 tcaggaaaaa ctgcatcaaa gatcaatacc gagacagagg tgacggtgat agaagcgagg 1124101 gtgccggtga atgttctcat ctccagccat tttaaagcgg taaaaagcat tgatacattc 1124161 acagcccaca ctgaaaatcc gtgggggatt tgaaacagat aatgcaatag caccgcaata 1124221 cctgctgcac cgcctgtcgg aatatcatgc ggaaataaaa acaaggacat gccgagtcct 1124281 tgtagtacgc cgcctacgac aatcataaac gtaagttttg ctttcatcag cagttcagcc 1124341 attaagtcat ttgctccttt atgaaaagac ttgtccgctg ttttcatttt atgaggctgt 1124401 ccattattta tgtctcaaaa taaagaaatg gcccagctta ataggctgag ccatcccact 1124461 tgtagcgatt gacgatctcc atattgatct ctgtgccaat gccttttcct ttcgggatgt 1124521 ggaccattcc ttttgaaggc tgcaggctga cgagatctgt aaaaggattc tccatgacgt 1124581 cccactcgat cggttcaatg tgatcgttct tcattttaga ccatgggggc agacaggctt 1124641 gtgcaaataa agcatagagc cgtgagagcg atccgtcata tgcatgggcg gatgctctga 1124701 cgccgaaata acgcgcgagc tggaggcagt cccgaaactc atcaattccg ttgacatgca 1124761 tgacatcggg ctgaatgata tccaaacagc gctgtgaaag gagaggcaca tattgcgccg 1124821 ggcctttcat gttttctccg ccggcaacag gaacagacaa acggcttcga agcatagcgt 1124881 aatcctgcgg ctgatcaaag ggcaaaggct cctcaagcca gccaatgttc gtccattcgg 1124941 agaaatagcg ctcccattta aaagccgcag cggcatcgta gctttggttt gcgtccagaa 1125001 tcatcgtaat ggagctgcct gctgtatgct gcagcgcatt gatgtgccgg acatcctcct 1125061 tgaatgaagt cccgccaatt ttgactttga tttgctcaaa accttttttc aactgggctt 1125121 caacattgga gactgagcgg ctgatccatt gcggggagtc tgagtacgat tgaaaagacg 1125181 cgtacacagg aatctcctct ctgtatcgcc cgccccataa ttcgcaaacc gaacaatccg 1125241 cagctttggc tgcaatctct gtcagcgcca tgcttacagc ggaggccgcc cgctggtgcc 1125301 atttttgaat cgtgcgcact aatgacaggc ggctgccagc ctgttttcct aatagaaatg 1125361 ggatgatccg cttcgtaaaa ccgacatgga gagcagggag ccaatcaacg cattctcccc 1125421 agccgtctat cccgctttcg gtgataatcc tgatgagata acaagtccga tatcgtttaa 1125481 acccattggc atctccgtat ggcttttcta atcgatgaaa tagcggaaag gtttcaatcc 1125541 gtacaatttt cacactgggt gctacctttc ctcagcgggc tggagccgat tgccagccat 1125601 tttagggtct tctttttctt ttgtttcttc attgttttgc ttcacatgga tgagcatcat 1125661 cacaagaatc ccgacaacga gagtcaatcc cgcgatgctt aaaaacatgc cgggtctgga 1125721 ccattgcatc aggcggccga aaatcggagg accgatcgct acccctaaga aacgtacaga 1125781 gccgtacagc gaggtgacaa atccccgtct ttctttgccg acagccccgg taatgaaact 1125841 gttcacacaa ggaaggacaa gacctgagcc tatactgctc agtacaagaa cactgataaa 1125901 aaggacaaga ttttcaatga atgacagtgc cgcgtaggat acggtcatga acgccaatcc 1125961 aagtacgatc agctttttca ttaacgattg cttttgcccg attttgcttc ctgttgtata 1126021 ggacgtcaca cacataacca aaagcgggat cgctaaaatt aagccttttt tcacgccgtc 1126081 ggtgtcgtat gttttttcaa gaacatctga gagataaaac aggatgccga ataaagtaaa 1126141 caaacaggtc gcaccggcta aataagcggt aaacagccat ctgccttcat gtttaaagac 1126201 acttaacagc ccttttgcat attgtccgat tggtggcggt tctttttcct ttttcttttc 1126261 tttaataaaa atccaagtca gtacgatcga aatgatacaa aacacaggaa aggcaaaaaa 1126321 cgcgccatac cagacaagca gggcgatcag cgagccaatg atcggcgata gcactttccc 1126381 catgccgttt gaagcttcaa caaggccgag caccttgctc tcctgggcgc ctttaaacag 1126441 atctcccgtc agtgccatgg caattgggcc ggttccggct gccccgattc cctgtaacgc 1126501 tcgtcctgcc atgacccaag gataggcatt gtcaaaaaaa cctgccgcaa acccggctaa 1126561 caaaccgccg gcaccataca aaattaagca gggaataatg atgactttcc ttgagaatcg 1126621 gtctgcgaga taaccgacaa tcggaatcgc aaatgctgca atcaaggaaa atactgtgat 1126681 cacgagactg acttgaaatt gtgataaatg aagttcagat ttcatttttg gcaaaatcgg 1126741 aataagcatc gagtttccta gggttaatat taaagggatt gaaccgattg ccacaatcgt 1126801 cattccgtta ttttgttttg atgattccat ctcagagcac actccttttc ttctgcttag 1126861 aatgtccctg atggcttcgt ttattcagcg atcagacagc aaaaaaccga acagaagata 1126921 cctgttcggg aaaaaagagg gttaaccgag agcctgtgaa atcaaagcat ataagtgtcc 1126981 attttgaata ggcgcttttt tctgatagaa caaaatcgga ggttcatcat ctttatgaaa 1127041 tcccatttct atcaggctgt catgcagaga cgtgtgttca ctcggtatat cgattcgcat 1127101 cggcccttgt ttgccggccg ccagccttgt aattatctgt gctgcaacat ctgatgatgg 1127161 agcgatgata gggccgaatt tcaaattggc cggtgtctgt acagaaagtc cgtagccaat 1127221 gagctgtccg tcctgatttc tggcgatgat acattcgcat gaagcagaaa taagctgctg 1127281 caaaaggttt gatcgatctc cgccaaaggc agccagatcc gccgcggtta agtcgtgaaa 1127341 gtcttgttct ctaaaggatg tcagttcagc atcaagcttt tttgtataag gttgaaaact 1127401 gtgacagctg tactttcgca ctgaacctgc cgtatgaaaa cctgcttttt cataaagcgg 1127461 caaaccttct tttgtggcgc aaagcctgat ggcggtgttt tcatccgttt gggtaataca 1127521 ggcgtttacc atacgccggc caagaccgag ccgttgatat tccttgtcaa cgataacaag 1127581 gccgatagaa gtaagacggc caaacaaaaa caagccgatg caggaaataa tatcaccgct 1127641 gacattttga taaccgaaaa agcgtccctg ctgaacaagc agtttcagct cttgttcgcc 1127701 ataatccggc cacccggctt gcccgcaaag ccgcaataag ccggaaacgt gttcttcatg 1127761 aagcttaatc agttcatcta ctacgtccat aagatcacct gcttgttcta agtgttttgt 1127821 acatgacaat atgattgcca atgccgggaa tgtcaaatgg ttcgccaagt tccttccagc 1127881 caagcttggc atagtagccc ttgacatggt gtcttgcgtt gcaccatacc gcctgaacgc 1127941 cgctctccgc cagtttgtgc tccgcgtgtt tgatcagcgt gcttccagct ttttgatcgc 1128001 gatatccctc gagcgttgcc atgcctctca gccgatacgc agaggcttcc gttaataaag 1128061 gctgactttg cggggaaaaa gaagcgatgc tgatcagcgt tccatcataa aacacgccga 1128121 gatgaaagga gccttctgcg tgatcctctt tatatttgca ttgttcgatg gattgatggg 1128181 gacgcagaat gcgatgccgg atttcatatg tatcttccac ggaaatggtt ttgacttcga 1128241 gcataatgtt cctcctcatg attgtttttc tatatcgtaa cacgaatctc gttgaaaaag 1128301 actgcccgat tcgatcaggc agtcttttgg aaattaatgc aaaaagatat tttggcgctg 1128361 ctcatctttt tgctgaatat atgatgtgag ctcagcggtt aagtcagatc tgaggaaagg 1128421 cgttatcaag tagatgccgt taaacagctc gcatgccgta tccagcaggg agcgtgcaat 1128481 tgcaaggcct tccgcctttt gcttttcttt atcttcaccg gcatgggcca ttttttcgcg 1128541 aatcgtatca gacagcttaa tgccgggaat ttcattatgg atgaattcgg cattccggct 1128601 gcttgtcagc ggcatgatgc cgatatagat cggcgtcttc agatgttttg tttcgttatg 1128661 gatatcgaca agctgctgct cggaatagac aggctgagaa acaaaataat ctgcgccgca 1128721 atctattttt ttctcaagcc gttttaccgc tttatccaga tggcggacgt taggattaaa 1128781 tgcggcggca actgagaaat tcgttttctt gccgagcggt tttccagaca gagacagacc 1128841 ttcattgaat tgtttgatca gcctgattaa atcaaaagat gttaaatcat atacagacgt 1128901 cgccccagga aaatccccga ttttagaagg gtcacctgta atagcaagca cgtcattcag 1128961 ccctaacgta tcaaggccca ttaaatgtga ctgtaagccg ataatgttac ggtcacggca 1129021 cgtaatatgg acaagggaac gcatatcgag ctgctgcttg acaagggcgc cgcaggcaac 1129081 attgctgatc cgcggggtcg ccaaagaatt gtcggcgagt gtcagggcat cgattcccgc 1129141 ttcttttaat tcagcagcag cggacagaaa tttgtcaaag cttagttttt tcggcgggtc 1129201 cagctctacg ataatagagc gttttttcgc tgcgatctca tccaggccgg gctcggttcg 1129261 ctcgtgatga acagaaatga attctttcgc ccgggttttg acttcttttt ccgtaatcgg 1129321 agccagcccg ccaaccgctt ccgccatcgc cctgatgtga ttcggcgttg tgccgcagca 1129381 gccgccgata atccgcgcac cttgcttacg gaattctgac gcgctgtttt gaaaatacgt 1129441 gtcgtctgtt tcatagacga gccgtccctc ttcaagcgaa ggaagactgc tgttcggata 1129501 aacggataag aatacgtcat caaaaatcgg cacttcgctt agcgcttcaa tcatgtgata 1129561 agggccgagg cggcagttaa tgccgacaat atcagctccg agatccgcaa tcgagcgcaa 1129621 tgcgtcagaa agcggcgttc cgtcctgcaa tacgccttgc tcgtgcatgg agacattgag 1129681 cataatcgga agatcagtct ctttgcgcgc gattttcagc acttcacggg cttcttccaa 1129741 atcataatat gtttctaaca gcaagccatc cggctcttca tgcagcagca gatacagctg 1129801 ctcgcggaag ctgcgcttaa tttcgtcaag actgtatgcg tttttattaa atgtgcgtat 1129861 gccgcccatc gttccaagca cgtatgcatc gcctgctgaa gcccgcgcga tctttacggc 1129921 ctcctgattc atttttttga tgtcatcctc aagcccgtgt ctggataatt taatatagtt 1129981 ggctccgtac gtattcgttt gaataatgtt ggctcccgct tcaacgtacg ctttatgtat 1130041 gcgctgaatt tcctccggct ttgaaatatt gagctcctca aaacacctgt caatgccata 1130101 ggagtagagg agcgtcccca tggcgccgtc accgattaac acctgtcttt gcaaatcttc 1130161 taaaagtccc attgtctgcc tcctttattc acatcagcaa ggaaaaaaga gaaataaaaa 1130221 aagtcctctt aagaagaaga ctttgtcagt gattttgtct cttcttatct tccaagctgt 1130281 tcgagcttgc tggatttagc accttggtca tggctgatcg ccattacacc ggttgctgaa 1130341 gcttcgtcgg gccagtccct ctgcttctct tgataagaac ggatatgaaa ttttcgtgtc 1130401 aggaagtgcc aaaagatatc tggcgttttt ccctttctcc aaatttaccg aaaataaaga 1130461 caataatcaa taggaatcag aaaatttatc tgaaatttat aaattgaacg tcaattggca 1130521 gatctgctcc ccgtacagct gagataatct gctgcaggtc atctttgttt tttccggtga 1130581 cacgcacttg atcatcctgc acctgagact ttactttcag tccggagttt ttgatgatcg 1130641 tattgatttt ttttgcgttg tccttgtcaa tgccttgaac aagctttgca cgctggcgca 1130701 ccgttccgcc tgacgcgttt tcaaccttgc cgtaatcaat gttttttgtc ggtacgtttc 1130761 gtttaatcaa tttgctgacc agcacatctt tcagctggct taatttgaat tcgtcatcgg 1130821 aaacgaggac cagctcctct ttatctaaag aaatgtcgct tttgctgcct ttaaagtcat 1130881 atcgggtact gatttccttc agtgcgattt ggattgcgtt ttgcacttca ggcaattcca 1130941 ccttggatac aatatcaaat gaactttctt ttgccatatg aaaacctcca taacatttaa 1131001 cttatgtgtt gattatagta gaataaagag aaacttccaa cagaacaaag aatcaatttg 1131061 tgatgattgg aaaaaatgtt aacaaaatcc gcagagaata agcggaacag gaaggacgat 1131121 agcatgagac cagggcagca attaaccttg agtatagatc accaaaccga cttcggttac 1131181 tttttaaccg atggggaaga tacgattctc ttacataaca gtgaaatgac tgaggatatc 1131241 gaggacagag acgaagtaga agtctttata tacgtagacc agcaggaaag gcttgcggcc 1131301 acgatgaaaa ttccgatcat cagcgcggat gaatatggct gggttgaagt ggtggataaa 1131361 gtggaagata tgggcgtttt cgttgatgtc ggtttatcga aggacgcact agtcgcaact 1131421 gagcatttgc cgccgtacga agatgtctgg ccgcaaaaag gggacaaact ttactgtatg 1131481 ctgaaggtga cgaaccgggg gcgcatgttt gcgaaaccag cgccggaaga tatcatcagc 1131541 gaactgttta ccgacgcttc agaagatctg atgaataaag agctgacagg tacggtgtac 1131601 aggctgatcg catcgggttc attcgtgatc acggatgacg gtatccgctg ttttattcac 1131661 ccgtcagaaa gaaaagagga gccaagactg ggttcaagag tcacaggccg ggtgattcaa 1131721 gtgaaagaag acggttcagt caacttgtcg ctgcttccga gaaaacagga tgcaatgtca 1131781 gttgatgctg agtgcattct aacgtatatg agaatgagaa acggtgccat gccgtacagt 1131841 gacaaaagcc agcctgacga tatcagagaa cgttttaata tgagcaaagc cgcctttaaa 1131901 cgcgcgctgg gccatttgat gaaaaacgga aaagtgtatc aggaaaatgg atggacatac 1131961 gagaaaaaat agcatgaaaa cggctcgcct gcagcagact gcggagcgag ccgttttttt 1132021 atgtctagtt taattcatca accagcgttc tgattgccat ttcgcgatcc acattgtctg 1132081 aaatcgcaat cggcgtaata tcaatggcga gaatgatcag aatcagggca cctgctgcag 1132141 caacataaga aacataatag aaatagttag cggtatcaac agtgttgaca agctcggcct 1132201 gaactctgga tgtatcatcc ttagaagcgg cgatttcctt tgcagcttct actttttctt 1132261 caacgatttg acctgctttt ttcagcagtt catccacttt caatgcatct ttgctgtaaa 1132321 cagctttctt caggttatca aaaaagtcag catcctcttt tttaatatca gcgacaacct 1132381 gattggcaaa agcctttgcc tgttttgtgt tgagtttgtc tgtcatcgct ttattaaaga 1132441 cctctggaag ctgtttgcca acttcccctt gggcaaacac aaagccttta aaaatttcct 1132501 cacctgaata ctcaagctgc tttgcctgtg ccacactttc ttgctgcttc accaaaaaca 1132561 cagtcgtcac caatacaacc gacaaaaata ctagaaacgc cttcttcaaa ctgaaacctc 1132621 tcccttcttg tgttttttat tccacaacag tctgcgaata tatgtaaatt gaatcgtgga 1132681 atcgatagga gtgagataca atatcaaaat gccggccatg ataatcgaaa aactgatgag 1132741 gcccagcatg actgcaaaaa tctcatgcat aaaaacagcg atgatcaaaa tcaatctcca 1132801 atgcttcttc ggcgcaaaca gtgccgcgaa gatgacaatt tgaaccagca gcgtccccca 1132861 tgtcggaatc accacgaacg gacttgttac aattggcttc gttaacgcct gaaaaaagcc 1132921 gttgaagcca atggtttttt cctgggcgaa ataatagacg gccgttccgt ccacccattc 1132981 ctgctgagat agcttagcga cggtagagtg aaaataaagc accgccactt ggattctgat 1133041 cacaaaataa gaaataaaag ctgttatttt tccaagtgtt cttttgccct ctataggtct 1133101 cgtactccaa tgccattttc tcggatcggt cagcgtgatg ggaagcaata aaaaggtcat 1133161 gactgctgct gcctgctcgc ctccgtcgat gacgatcagc gatgactgca ggctgtaact 1133221 gacataccaa tgcagaaccc cggtgattct ggggcgccag ccaatgacaa caagcaccag 1133281 aatggcaatg cagacccatc tgaaaagatt taacatcata tagttatttt cgccgagaca 1133341 aaagagactg agattcattt tacaagctgg atagctgctg atcccgctgg ctggcttcat 1133401 aatgaggctc gggtgattga tgagcagcgt cagcaggctg gatagcgcaa tgatgcttcg 1133461 cgcgaggcca tatacatttg tccacgggtt tctttcgtcc catctggtga tggtctgttt 1133521 tatgttttcg agcatgagat cacaaccttg actatgcttt ttacctgata agacgaaggg 1133581 gtatatttag aatagctcca aggaacaata tcctctttcg tcaaatagta gctgccacaa 1133641 agcagcgggc ggggagcggg tgtttttaat tgcacggttt tggctttgct tttgcatgcg 1133701 ccgaggtcct tttctttaca tgctgtccac tgttccttgc cgacttggct gtagatcacg 1133761 cccatttcaa cgccttgtga ccgcccatac cgatacaggc cgaataggtt gtcagccctc 1133821 atattgggcc atctgacctt ggcgctggca ttttcagcct catataagcc gattgcagta 1133881 tcacgcggat ttttgctaaa aaagccccag ccctgaggga ggatgctgga catgagaaat 1133941 ttggagtcct ttgtcagcgg aatcggggtt gtccctaagc tgccaataat agaaaacaga 1134001 aatagcgaac cccaaaggat tgaaaaaatg acaaaaaatg atatcgattt ctgcattcga 1134061 ctgctccttt taacctgaag aatcgttttt acacttttca taatataaaa acatttatgt 1134121 aataaaaagg ttaaaaagta tgagaaattc catttttgtt aaaaggaaaa acaggacatt 1134181 ttacactgct atatgtgatt gatatatagt gtttttttcg atatatttaa accatgaaaa 1134241 cgaatcaagt taatgaccgc tggattgttc aatttcgaaa agggattttc gagctggcca 1134301 tcctatccct tctgcgttct aaaccgatgt acggttatga gctgacgtca tccttaaaaa 1134361 ccacctcggc gctggctatt tcagagggag cgatttatcc gattttgaaa cgtatgaccg 1134421 agaagggatg gatcgaattt ttttgggaag attcactgga cggcccgaaa agaaagtatt 1134481 acaaaatgac gcaaaaagga gaagaaatgt taaaagaacg gctggagaaa tacctggaaa 1134541 cccatcaagc cttactgtct ttatcggggg atttgctatg aatggacagc ttatcattga 1134601 ccgatacatg gaggaactaa atgcagagct ggcgaatatg cctgatgtag agagagaaaa 1134661 cgctatcgac gaattaaagg ggcatatcac cgctttcgtt caagacagaa tcaaagccgg 1134721 ccttagtgaa gaggaactgc aggaagctgt tgaatctgaa ttttctcatc cgaaggagct 1134781 tgccgaattg atgatgggtg atgggggaga gacgaaaagg aggaggtctt tattgggcaa 1134841 aagctggatt tcggtccttc tcattgtcac gattatcgcc ctgccgctgc tgccgtccga 1134901 cttcagacat ctgccgctgg ctgtttattt aatggtgctc gccggatatg tatggaagcg 1134961 gaaaaaattg gtgatgtttg caggtgtcag aaaaaacaaa atgcgctctc aaaaggagat 1135021 tgtcaagatt tcgcgagtcg gtgcggttta tctgctgttt ttagcagtgg tgctcctttt 1135081 gagcccgttc ctcaatgcgc ttgtcgtcct gctgctgatt gcagtaagct gcgccgcttt 1135141 ttttcttttt cttaacatca agtaatcttg taggaggctg taagatggaa atcagcatca 1135201 attatctatt aattgtcatc gcgcttttat tctttgtggt tgcctatttt gtcggaatca 1135261 aaaaacaaac ctggatgttg gctgggttta acgaggcgcg tatacgggat aaagatcggc 1135321 tggccagaat agcaggctac tttttcttga attccggttt gttcattttg ctgaatagtt 1135381 ttatctcatt tcaaggtcag gagcagctca tacctccgct tatactggca tatggagcag 1135441 gggttattat ttatgtcaat aaaaaattag tagagtagaa aaagaagggc agagcgaaat 1135501 atctctgccc ttcttttttg ggaaaataag aacgaagcac cacatacaag tttttgtatt 1135561 tttgatagga tgaagaaaaa tggtagattc caaaatagga aggatgtggt gttttgcgca 1135621 acttgaccaa gacatctcta ttactggccg gcttatgcac agcggcccaa atggtttttg 1135681 taacacatgc ctcagctgaa gaaagcatcg aatacgacca tacgtatcaa accccttcat 1135741 acatcatcga aaagtcaccg cagaagccgg tacaaaacac aacccagaaa gaatcgctat 1135801 tttcctatct tgacaagcat caaacgcagt ttaagctcaa agggaatgcg aacagccatt 1135861 ttcgcgtttc gaaaaccata aaggatccaa agacaaaaca aacgtttttt aaattaacgg 1135921 aggtttacaa aggaattccg atttacggct ttgaacaagc ggtcgcgatg aaggaaaaca 1135981 aacaagtgaa aagtttcttt ggaaaggtgc atccgcaaat caaggacgtc tccgtcacac 1136041 cgtctatttc tgagaaaaaa gcaatacata cagcaaggcg tgagctcgag gcttccattg 1136101 gaaaaatcga atatcttgat ggggaaccaa aaggcgaatt atatatctat ccacacgacg 1136161 gtgaatatga tctcgcctac cttgtgagac tctcgacatc tgaacctgag cctggctatt 1136221 ggcattattt catcgatgcc aaaaacggaa aggtcatcga gtcctttaat gccattcatg 1136281 aagcggcagg tacaggaatc ggcgtgtcag gtgatgaaaa aagctttgac gtcacagaac 1136341 aaaatgggcg cttttatttg gctgacgaaa caaggggaaa agggatcaat acatttgacg 1136401 cgaagaacct gaacgaaacc ttgtttacgc ttttgtctca actgatcggg tatacgggca 1136461 aagaaatagt cagcggcacg tccgtattta atgaacctgc ggctgtagac gcacacgcaa 1136521 atgcgcaagc cgtttacgat tattacagca agacatttgg ccgtgattct tttgatcaaa 1136581 acggagcaag gattacgtct accgtgcatg tcggcaaaca atggaacaat gctgcgtgga 1136641 acggtgtcca gatggtatac ggggatggag acggttcgaa atttaagccg ctgtctggat 1136701 cgctcgacat tgtcgcgcat gaaatcacac acgcagtcac acagtattcc gccggtcttt 1136761 tatatcaagg agaacccggt gcattaaatg agtccatttc tgacattatg ggcgcgatgg 1136821 ctgaccgtga tgattgggag atcggcgaag atgtctatac tcctggtatt gcaggagatt 1136881 cattgcggtc attggaggac ccatctaagc agggaaatcc agatcattac tcgaaccgct 1136941 acacaggaac agaggattat ggcggagtcc atatcaattc gtccattcac aataaagcag 1137001 cttatcttct tgcagaagga ggcgtgcacc acggtgtaca ggttgaaggg attgggcgtg 1137061 aagcaagtga acaaatttac tatcgggctt taacatatta tgtaacggca tctacagatt 1137121 tcagcatgat gaagcaagcg gcgattgaag ctgccaatga tttatacggt gaaggctcga 1137181 agcaatcagc ttcagtcgaa aaggcgtatg aggctgtcgg cattctatga gcaaacaaaa 1137241 acagtcagga cacagagtct gactgttttt gtttgctcat tttcttaaaa agaatatcgc 1137301 caatgtacct ggaccggcat gcgagccgat ggctgaactg attggatgca taatgatttc 1137361 tttcggcttg aacgcttcct caatcaggtg tttcatatcc gtggcttttt ctttgttcgc 1137421 ggcgtagcta atcccgacgg tttgattgct ccaatcatcc ccgcgctctt tcataagctc 1137481 gatgatccgt ttgaaaagtt tcttctgtcc gcgaattttt tccagaggca caagcttgcc 1137541 gtcctccatc tgaagcagcg gtttaatatt caacaggccg ccgacaaaag cggacgtttt 1137601 ggatatccgg ccgcccctcg cgagatatgt taaatcatca acggtaaaaa tgtgttcaag 1137661 ctggctgcaa aagttcttta cagacgtttc aatttcttgt attgtattcc cgttgataca 1137721 gagatcggca gcatgccgga cagccagacc gtatcctaat gaagcgcatt tggaatcaat 1137781 gacccgcaaa tcgaaatcgg ggaattcctc cttcacttca ttggcgatca ttacagctgt 1137841 ctgatacgtg ccggagagac ctgaggaaaa ggcaatgtaa agagcgggat cacctgtttc 1137901 ggcatattgc aaaaacacat ttttaatcgt ttgcggtgag gcttgggacg tcttaggcgt 1137961 ttctccattt tgcatcgctt caaatatttg atccgcatga attgtgactg catcttcgaa 1138021 ttctttatcg ccgagagaaa ccctgagcgg aataaagcca atgccttttt cttcaaaata 1138081 agaacgaggc aaatcagtgg cgctgtcagc gatgagatga actgtcatat tgcttccctt 1138141 ctttccgtta tcgctcgtta tcatgagagt taagccaact atatcatatt aatttgccaa 1138201 aatcgtgttc aaatatttgt tttaagggaa aacataataa agaagaaaga gcggaggaac 1138261 atgccatggt actagatcaa acaaaaaaat tactcatcgt catcatcggc gctttactca 1138321 atgctgccgg gctgaactta tttttgatac ctgcagatgt atatgccagc ggatttacag 1138381 gtgttgccca gcttttatca agcgtcgttg atcaatatgc ccccttttac atatcgacgg 1138441 gaacgctctt gttcctctta aacattccgg tcggtatttt aggatggctg aaggtcggca 1138501 aatcgtttac agtgtacagc attttaagtg tcgcactcac tactctgttt atggggatcc 1138561 tgccggaaac aagcctgtca catgacattt tgctgaacgc ggtgttcggc ggcgtcattt 1138621 ccgcagtcgg tatcggctta acattaaaat acggagcttc gacaggcggg cttgatatcg 1138681 tcgccatggt acttgcaaag tggaaggata aacccgtcgg cacgtatttc ttcattctga 1138741 acgggattat catcttgacg gcaggattat tgcaaggttg ggagaaagca ttatataccc 1138801 tggttacact atatgtgaca acgagggtga tcgacgccat tcacactcgc cacatgaagc 1138861 ttacggcaat gattgtgacg aaaaaagcgg acgaaatcaa ggaagccatt tacggaaaaa 1138921 tggtgcgcgg catcacaact gttccggcaa aaggagcatt tacgaacgaa cagaaagaaa 1138981 tgatgattat cgtcatcacg aggtatgaac tgtacgattt agaaaagatc gtcaaagaag 1139041 ttgatccaaa agcatttacg aacatcgttc aaacgacagg gatttttggt ttctttagaa 1139101 aagactgacg aaagcaggtg gaagtcgtga aacggctgct tgtgatgctc ctccccgtgc 1139161 tgcttttgat aggctgcggg aaagatgagc agacagaacc cgataaggag gtatcaggcg 1139221 gaatggagaa tcaagaggtt gttttatcta ttgacgcaat tcaggagcct gaacaaatca 1139281 agtttaacat gtcgctgaag aaccaaagcg aacgtgctat tgagtttcaa ttcagcacag 1139341 ggcaaaaatt tgaacttgtc gtgtatgatt ctgagcacaa agaaagatac cgttattcga 1139401 aagaaaaaat gtttacgcag gcttttcaaa acctgacgct tgaatctgga gaaacatatg 1139461 atttctctga tgtgtggaag gaagtccctg agcccggaac ctatgaggta aaggtgacat 1139521 ttaagggcag ggcggaaaat ctcaagcagg ttcaggctgt tcagcagttt gaagtcaaat 1139581 aagaggctat ggcgagtcgc catagccttt ttttattgca gtttgtccag ctgattttga 1139641 aattgatgca actgttgacg ttccgcatct gtcgaattgg catacgcaga agatacagca 1139701 tttttggctc tcagaatcgc ttgctcctga tcgccttcct caaagccgtt tgtcaccatg 1139761 accgcctgtt gaacaaatga ttttgcctgc tgaaacagtt catttctcat ttaatattca 1139821 tactgccttt cagccgagtc tcgtgccgcg gcatgctggt gagcttcttc taaagtagac 1139881 cgatatggaa atcttgcggc gtgtagcccg atggagtctt taccctgctg aataaacctt 1139941 ctggatttgc ttcgtttacc cattttgaga ctgccccctt ccatactttg acgagatgag 1140001 tcgtcttcaa tagtatggtg gggtaaagta aggtttatga gtgggaaaaa ttaatacgga 1140061 ccttctttaa agtgagaaat attctttcaa aaaccttgcc acgccgtcct cttcatttgt 1140121 ggccgtagtt cggttggcaa tctgcttgac cgcgtcaatt ccatttccca ttgcaacgcc 1140181 gcagcctgca aattcaagca tttccaaatc gttatcctca tctccaaaag caatgatccg 1140241 ctccctcggc acgccgtaat aatcgctgat tttctgcagg ccgaccgctt tattcatgcc 1140301 gcttttgata atttcaatga catgccaagg agcggcccat cttctatggt cgatcacctc 1140361 ggcatgcaca tccgataaat atgagcgtat tgccggcaca tcctcttcct ttgcatgtat 1140421 gagtacggac gtcacatctt caccgagatt ttcccgcaag tctccgaccg ttacatttgt 1140481 tgtgttcatg ttaaaggcat ctatcaggtg ctcatcatgg taatgaaagt atacgtcgtc 1140541 aatcacttca gcaagcacgt tatgtacgtt gtagctctcg ctgatatcca cgagctgttt 1140601 gacaacatca agcggcagtg acgtatgata ccgtccccag ctgtcgtctt gcggatgatg 1140661 gacaaatgct ccgttaaaat tgacaattgg cgttgtcagc tccatctgct ggtagtacat 1140721 ggaacttgaa cgatacggac ggcctgttga gatgcagaca taatgcccgt catcttttag 1140781 gcgctgtatc gtatgaaggg tgttttcaga tatggtttta tcatccttta ataatgttcc 1140841 atctaaatct aatgcgatta aatagggttt tgtctccatg aaaagctcct ttaaccttag 1140901 attttgcttg ttttgcctta cttacagtgt agctttttac catctttatt gtctacatgt 1140961 tacacttatg attatggtta tcctaaggag gggcacattg tgatacaaat tgagaatcaa 1141021 accgtttccg gtattccgtt tttacatatt gtaaaggaag agaacaggca ccgcgctgtt 1141081 cctctcgtga tctttataca tggttttaca agcgcgaagg aacacaacct tcatattgct 1141141 tatctgcttg cggagaaggg ttttagagcc gttctgccgg aggctttgca ccatggggaa 1141201 cggggagaag aaatggctgt tgaagagctg gcggggcatt tttgggatat cgtcctcaac 1141261 gagattgaag agatcggcgt acttaaaaac cattttgaaa aagagggcct gatagacggc 1141321 ggccgcatcg gtctcgcagg cacgtcaatg ggcggcatca caacgcttgg cgctttgact 1141381 gcatatgatt ggataaaagc cggcgtcagc ctgatgggaa gcccgaatta cgtggagctg 1141441 tttcagcagc agattgacca tattcaatct cagggcattg aaatcgatgt gccggaagag 1141501 aaggtacagc agctgatgaa acgtctcgag ttgcgggatc tcagccttca gccggagaaa 1141561 ctgcaacagc gcccgctttt attttggcac ggcgcaaaag ataaagttgt gccttacgcg 1141621 ccgacccgga aattttatga cacgattaaa tcccattaca gcgagcagcc ggaacgcctg 1141681 caatttatcg gagatgaaaa cgctgaccat aaagtcccgc gggcagctgt gttaaaaacg 1141741 attgaatggt ttgaaacgta cttataaagc actaagttat taacaagagc tgaatttacg 1141801 ttatactgta gaaaaaagga gtgagggaac gtggaagaag cattaaaaga aaacatcatg 1141861 ggcgccctgg aacaggttgt cgatcctgag cttggcgttg atatcgtgaa cctcggcttg 1141921 gtatatgacg ttgatatgga tgaagatggc ttgacgcaca tcaccatgac gctaacatca 1141981 atgggatgcc ctttagcgcc gattatcgtg gatgaggtga aaaaagcatt agcggacctt 1142041 cctgaagtga aagacacaga ggttcacatt gtatggaatc cgccttggac tagggataaa 1142101 atgtccagat acgcaaaaat tgcgcttggc attcaataaa acaaaaaagg acagcctgac 1142161 atgtgaggct gtcctttttt acagctgaaa ggagtgaaag gaaatgatgt acctgctggc 1142221 agttttatgc ccgccgcttg ctgttttgtt ttcgggaaaa ccgtttcagg ccttgctgaa 1142281 tctcatattg acctgtatct tttggctgcc gggcgcgatt cacgcctgct ttatcgtcgc 1142341 cgaccgccgt gccgaaaaac gggcaagaag ataatttgga aaaatgagga cgcagtcatg 1142401 gtataatggt cataaaaaca gcagggagag cactatgaaa aagaaattgc ttgcattcgc 1142461 gctttgtact ggcgcgtatg cggccctgtt tgcgtactct gtgaactcag agcaaaaaac 1142521 agccacaagc gagatgacgg atgtcagccg cctgatgcct gtaaaaataa agcagacagt 1142581 gaaagggcag gaagaggaaa tgctcattga cacagtcaaa gaggcaaatc gaaaaaacat 1142641 aaaaatttca atcgccgggg cccagcactc catgggcggc catacatatt atgaggacgg 1142701 catcgttctc gacatgacgg gctacaacaa aatcctgtca ctcgatcaag agaagaaaac 1142761 catcagggtg caaagcggtg caacgtggaa tgatatccag aaatacgtga atccatacgg 1142821 actcgcggta aaagtcatgc agtcacaaaa catttttaca atcggcggat ctctcagcgc 1142881 aaatgcacac ggacgtgata ttcgctacgg ctcgctaatt gatacagtca aatcattccg 1142941 gcttttaaaa gctgacggga tgattatcac tgtcactcca aaagatgatt tgtttacggc 1143001 ggtcatcgga gggtacggcc tttttggcgt gattcttgat gtaacgcttg agctgacaga 1143061 tgatgagctg tatgtcatga agacagaaaa aatgaattac agcacatact cagactattt 1143121 ttcaaagcat gtaaaaggaa atccagatgt ccgaatgcat ctggcgcgaa tttcaacagc 1143181 gaaaaaagga tttctgaaag acatgtatgt cacgaattac gtattggcta atcatcagga 1143241 tcagctgtcc tcatacagcg aacttaaaga agacgagtat acgggagcca caaagtttgc 1143301 actcggcttg tcaagacggt atgaatgggg gaggaattgg ctgtgggaca cacagcaatc 1143361 ctatttcctg agccagaacg gcacagagat ttcacgcaat aacgtcatgc ggtccgaatc 1143421 aaagtttctt gagtatgaaa acaatgacaa cacagatgtt ttgcaagaat actttgtgcc 1143481 cgtgaaggag tatgggtcct atattgatga cctgagacaa acgctgtcgg acgaagatct 1143541 gaacctgctg aacattacga tccgctacgt gcagaaaaat gaaaaggccg acctttccta 1143601 tgcgaaggac gatatgtttt cgctcgtact attaataaac gagggctttt caaaagaaga 1143661 ccaggcagat accgcccgaa tcatcaggcg catgacagac gttgccatca agcacggcgg 1143721 cagctattat ctgccttata tgacctacca gacaaaagcg caaatgagac aggcatatcc 1143781 gaaaagtgaa gcgttttttc agaaaaaacg aacctatgac ccggatgagc gctttatgaa 1143841 ttacttttat cagaggtata aataatgggg aaaaacaaat taaaatggct gacattatca 1143901 caaagcagcg tgtttttcgc aagcagctta atctttccgt tttatattct gtttgtgaaa 1143961 aatatcggct caagctacac acagttcggt ttttcctacg gattgttcgg gttgagcgga 1144021 gcgcttattt acccgctcct cggacggctg tctgaaaggt ttgacagccg ttattttctg 1144081 cttctgaact cgtgggggat ggctgttctg cttttatatg tcccgcatat cggaagcgtc 1144141 gttcaagtgt atatcgtcca agtgctgtta gggctctttg gagcgatgca aaagcatgga 1144201 gaaaaagtgc tgatcgctaa ttttacagac agtggagagc gtggaaagaa gatcgggaat 1144261 taccattttt ggacagctgt cttttcagca gcagccatta tgctcggggg ctttctcgct 1144321 gactttttca cagtgcaaat gattttttat gcaagctcta ttctatattt tttgagtgga 1144381 ttgatgatga tgaaaacagg ctgacgcggt cagcctgttt ttttatgcgg ctgaaatgcg 1144441 gcaccgcatc aacgtttttg tgctggagtc gtgctgattt tttttgagcg gaattcccat 1144501 tgaacagaaa atttataaat gaataaaaat attaaatata cgattgaatt aatttttatt 1144561 catgttataa tgttaaataa tttcacaaag accaagaggg tgaacttgtt ttgaaaatag 1144621 gaattgtagg tgctacagga tatggaggca ccgaacttgt caggattctt tcgcatcatc 1144681 ctcatgcaga ggaatgcata ctttattcat ccagcggaga agggaatgtc tatagcgagg 1144741 gttatcctca tcttaccggc ttagcggatc agcagctgaa gccgattgat atgaatacga 1144801 tcaaacacga aatagatatc atgtttctcg ctgcgccgcc cggagtatca agtgaattga 1144861 ctccaaagct ggcagacgcg ggaattacgg ttattgatct gtcaggtgat ctgaggataa 1144921 aagaaccggc tgaatatgaa aaatggtata aacggacagc ggcaccgaag gcggtgattc 1144981 aagaggcggt atacggtctg gcagaactga atcaactgca aattcaacag gcgaaactca 1145041 ttgccaatcc aggctgtttt ccaacagctg ttttgcttgg cctcgcgcca ttggctcaaa 1145101 agaaactgct cgatgaatct ttcgttatcg ttgacgcgaa gaccggtgtt tccggagcgg 1145161 gaagaaaagc atccatggga actcattttt ctgagctgaa cgacaatttt aaaatttata 1145221 aagtcaatga acatcagcac acgccggaaa ttgagcaggc gctgaatgaa tggcagccag 1145281 gtctcgggcc cattacattt tcggctcact tggttccgat gacaaggggc atcatggcga 1145341 cgatgtatac cagattaacc tgtgacctaa ccgcagatga cctgcatgat ttatattcgg 1145401 aattttacca agattcatat tttgtgagag tgaggccaaa aggtcagtac ccgcaaacga 1145461 aagaagtgta cggcagcaat ttctgtgata tcgccgtgac cctcgatgag agaacgaaca 1145521 gagtcacgat cgtctcggta atcgataatt taatgaaggg tgccgccggt caggcagtgc 1145581 aaaactttaa tttgatgaat ggctggaatg aagaaactgg actcaccatc acgccaattt 1145641 atccatagaa cgggagagaa tcgaaccatg attcagttaa gtgaagatca aattgtaaaa 1145701 gtaacaggtg atgtatcctc gccaaaaggg tttcaggcaa agggtgtgca ttgcggactg 1145761 cgctactcga aaaaagacct cggcgtcatt atcagcgaga caccggccgt gagtgcagca 1145821 gtttataccc aaagccactt tcaggctgct ccgatcaaag tgacacaaga cagcttaaag 1145881 cacggaccga cactgaaagc cgtcatcgtc aacagcgcca ttgccaacgc ctgcacggga 1145941 gaacagggct taaaggacgc atacacaatg cgggagagct ttgcttcaca gcttggcatt 1146001 gagccggagc ttgtcgctgt ttcatcaacg ggtgtcatcg gcgagcattt agacatggaa 1146061 aaaatccacg cggggatcga actgctgaaa gaaacacctg cgggatcagg cgattttgag 1146121 gaagcgattt taacaactga tacggtgatc aagcagacgt gctatgaact ggcaatcggc 1146181 ggcaaaacag tcacgatcgg cggagcggcc aaaggctctg ggatgataca cccgaacatg 1146241 gccacgatgc tgggatttgt gacaactgac gcggcaatcg aagaaaaagc gctgcaaaag 1146301 gcgcttcggg aaatcactga cgtttcattt aaccaaatca cagttgacgg agaaacatcc 1146361 acgaacgaca tggtattagt tatggcgaat ggctgcgccg aaaacgagtg cctgacagaa 1146421 gaccatccag actggccggt ctttaaaaaa gcgctcttgc tcacttgtga ggatctagct 1146481 aaagagattg ccagagacgg agaaggcgcg acaaaactaa ttgaagccca agtacaggga 1146541 gcgaaaaaca atcttgatgc aaacgtcatt gccaaaaaga ttgtcggctc aaatcttgta 1146601 aaaacggcag tatacggaac agatgccaac tgggggcgga tcatcggagc catcggacac 1146661 tccgcagcac aggtgacggc agaagaagta gaggtttatc ttggcggcca atgcctgttt 1146721 aagaataacg aacctcagcc attctctgaa tctatcgcca aggaatacct tgaaggagat 1146781 gaaatcacca ttgtcatcaa gatggctgaa ggggacggaa acgggagagc gtggggctgt 1146841 gacctgacct atgactatat caaaattaac gcgagctatc gcacgtaata aaggggagcg 1146901 aaatgaagaa aacaatcgtt tttaaatgcg ggggaagcgt catccgtgag ctgtcggagg 1146961 aattttatca aaatctgaaa gagctgaggg cgtcaggctg gaagctggca atcgtacatg 1147021 gcgggggacc ggaaatcaca aatatgctga aacggttaaa tatcaagaca gagttttcgg 1147081 gcggacagag gaaaacaacg aagccggtgc tggaagtggc ggaaatggtt ttatccggtt 1147141 ctgtcaataa atttttcgtt gctgagcttg ccaaacacgg actgcgagcc gcgggcattt 1147201 ctggtaagga tggcggtctt ttggaggctg attatctaga tccggaaaca tacggagaag 1147261 tgggagaaat caaaaaagtc gatgcgtcca tggtgaacgc gctgatggaa aatggcatca 1147321 tccccgttat tgcgccgctg tctatgacaa gcgactgcaa aacgctgaat gtaaatgctg 1147381 atctggctgc ttcagcagtc gccggagcgc ttgaagccga taagctgatg ttcgtcacgg 1147441 atgtcgatgg aatcatgaag gaaaagcagc gtctggacgt cctgacccct aaggagattc 1147501 agatgctgat caagcaggaa gtgatcacag gagggatgat cccgaaggtc aattcagcct 1147561 tgtcagcttt atcagatcag gtgtctgaag tcatgatcgt aaacggtaaa ggatcattct 1147621 tcgcagaaca aacctttcaa gggacaaaaa ttgtcaaagc aaaggaggct gtttcatgag 1147681 cagcttgttt caaacctacg gccgttggga tattgacatc aaaaaagcaa agggaacgta 1147741 cgttgaggat caaaacggca aaacgtacct tgatttcatt caggggattg cggtatcaaa 1147801 tctaggacac tgccatgaag cggtgacaga ggcagtcaaa aaacagcttg acagcgtatg 1147861 gcacgtatcc aacctgtttc aaaacagtct ccaagagcaa gcggcgcaga agctggcagc 1147921 gcatagtgcg ggagatcttg tctttttctg caacagcggc gcggaggcga atgaaggtgc 1147981 gataaagctt gccagaaaag caactggaaa aacaaaaatc atcacttttc ttcagtcgtt 1148041 ccatggccgc acgtatgcag ggatggctgc gaccggacag gataaaatca aaacaggctt 1148101 cggcccgatg cttggaggct ttcactacct gccatacaat gatccttctg cttttaaagc 1148161 tcttggggag gaaggcgata ttgccgcggt gatgcttgaa acagtgcagg gagaaggagg 1148221 agtcaatccg gcgagtgctg aatttttatc agccgtacag tcgttttgca aggaaaagca 1148281 agcccttctc attattgatg aaatccagac cggcatcgga cggacgggaa aaggcttcgc 1148341 atatgagcac ttcggactct caccggatat catcacagtc gccaaaggat tgggaaacgg 1148401 ctttccggtc ggcgctgtca tcggaaagaa acagcttgga gaagcgttta cccctggttc 1148461 tcacggaacg actttcggag gaaacatgct ggcgatggct gctgtgaatg ccacattgca 1148521 aattgtattc cagcctgact ttttgcaaga ggctgctgac aaaggggcgt ttttaaaaga 1148581 acagcttgag gcagagctaa agagcccttt tgttaaacaa atccgaggta aaggattaat 1148641 gcttggaatt gagtgtgatg gcccggttgc tgacattatt gctgaattgc agacattagg 1148701 cttgcttgta ttgccggccg gcccgaacgt gattcggctg ctgccgccgc tcaccgtgac 1148761 taaggatgaa atagcagaag ccgtcagcaa gctgaaacag gcaatcgctc atcattccgc 1148821 tgtaaaccag tgattttttt tcgatataaa ggcataaaaa ttcattttta taattaatta 1148881 ttcatcaaga ggtgggctgt tagatggaag gttatttagt gttagaagat gggacatcgt 1148941 tcagcggcga gctggacggt catgaaaact gcacgggaga agctgttttt ttcacaggaa 1149001 tgacaggcta ccaggaagtg ctgacagatc catcatataa gggacagatt attgtattta 1149061 cctacccgct gattggcaac tacggcataa atgaaaagga ttttgaaagc aagaaaccgc 1149121 aagtaaaagc cgcggttgtc tatgaggcgt gtgatcactt ttctcattat gaagcggtat 1149181 acagcctcaa ggagtatcta cagaaatgga atattccgct gttaacccat gttgatacga 1149241 gggctgtcgt gaagaaaatc cgggcaaacg ggacgatggg tgcgacagtc acagcctcta 1149301 aagaaggagc tgagattgcc cttcaaccag agaatgtggc agagcaggct tccgcccagg 1149361 aaatcagcac attcggcgac gggaataaac atatcgctct cattgatttt ggctataaaa 1149421 agtcaatcgc atcatcactt gtcaaacgag gctgcaaggt taccgtggtg ccataccagc 1149481 aaatggaggc cgtatacaac atcaaacccg atgggctatc gaacggacct ggagatccga 1149541 aagccattca gccatattta ggaaagatca aaagcatcat cagccgcttt ccgactctag 1149601 gcatttgtct cggacatcag ctgatcgcgc tcgcgtttgg agggaatact tttaagctgc 1149661 cattcgggca caggggagct aatcatccgg tcatcgaccg taagacgaaa cgggtcttta 1149721 tgacaagcca aaaccacagc tatgtggttg atgaacagtc gattaatgaa gaagagctca 1149781 ccatcaggtt tcatcatgtc aatgatacgt cagttgaagg gcttgcccat aaaaaactgc 1149841 ctgtcatgag tgttcaattc cacccggaag cccatcccgg acctgcggaa agcgaatgga 1149901 tttttgatga ttatctaaag aatgtgatac cagcaaggag agaaatcgcg catgcctaaa 1149961 gacaccagta tttcaagcat attagtaatt ggctcaggcc cgatcatcat cgggcaggcg 1150021 gcagaatttg attattcagg cactcaaggg tgcatcgcgc tgaaggagga gggctaccgg 1150081 gtaattctcg tcaacagcaa tccggcgaca attatgactg atgaagcctt cgctgatgaa 1150141 atttattttg agcctctgac agcagaaagc ctgacagcca tcattaagaa agaacggcct 1150201 gatgggcttc ttgccaattt aggcggtcag accgcgttga atttagcggt ggagcttgaa 1150261 gaaacgggtg ttttaaaaga gcacggcgtc aaactcctcg gcacatccgt tgaaacgata 1150321 caaaaaggag aggaccggga aaaattccgt tcgttaatga atgaattaaa acagcctgtg 1150381 ccggagagtg aaattgttga taacgaggcc gatgccctcc attttgcgga atccatcggt 1150441 tttcctgtta ttatcagacc agcttacaca ttaggcggaa agggcggagg aatcgcccct 1150501 gataaagaag cctttacagc tatgattaag caggcgctat tagcaagccc gatcaatcaa 1150561 tgccttgtcg aaaaaagcat tgccggcttt aaagaaattg aatatgaagt catgcgtgac 1150621 agcaataaca catgcattac cgtctgcaat atggaaaata tcgatccggt cggcgtgcat 1150681 acaggtgact ctatcgttgt ggcgccgtca caaacattga cagacgaaga ctatcaaatg 1150741 ctgcggacag caagtctgac gatcatctca gcacttgatg ttgtaggcgg ctgcaacatt 1150801 caattcgcgc ttgatccatt cagcaagcaa tattacgtca ttgaagtgaa tccgcgtgta 1150861 agccggtcat cggctctcgc atctaaagcg accggttatc cgattgcgaa gatggccgcg 1150921 aaactggcag tcggatacac tcttgacgag ctgaaaaatc cgctcacagg ctcgacttac 1150981 gcaagctttg aaccggcact ggattatgtg atcgtcaaat ttccgcgctg gccgtttgat 1151041 aaattcaaaa acgcagaccg caagcttggc acaaaaatga aagccaccgg tgaagtgatg 1151101 gcgattgaac ggaatttaga agcggcgata caaaaggcag ccgcgtcgct tgaattaaaa 1151161 aatatcggga cacaccttcc agagctcagc gggttgtcaa ttgatacgct atgggatttg 1151221 gcaatcactc cggatgaccg cagatttttc gttgtcatgg agctgttgag ccgcagcgtc 1151281 tcgattgatg acatccatga aaaaacaaaa attgatccgt ttttccttca tacctttgac 1151341 aacatcatca aattggaaaa ccgcctgatg gaagcaggga gcgatctctc ttttgaatta 1151401 ttgaagaaag caaaggaaaa gggattctca gacgcaacga ttgcctcgct gatcagcaaa 1151461 acagaagaag aggtgcgcgc gcttcgcaag gagatgggca ttacgccttc ctttaaaatc 1151521 gtagatacat gcgcggcaga gtttgatgcg aaaacaaact atttttactc cacatatttc 1151581 ggagagaccg atggagacat cagccgcaaa gagaaaaaac gcgcgctcat tatcggatca 1151641 ggcccgattc ggatcggcca aggcgttgaa tttgattaca gtgctgttca cggtgtgctg 1151701 acactgcaag agcttgggtt cgaaaccatc atgattaaca ataacccgga aactgtcagc 1151761 accgattatg aaattgcgga ccgcctgtat tttgaaccga tgacaacgga gcatattgta 1151821 aacgtggcgg agcaggaaaa tattgatttt gcaattgtgc aatttggcgg tcaaactgca 1151881 atcaatgctg ctgaagcgct cgaaaaagcc ggcattactc ttcttggcac atcatttcaa 1151941 acgctcgacg tgttagagga tcgggatcaa ttttatcagc ttcttgacga gctgggattg 1152001 aagcacgcaa aaggagaaat tgcttataca aaagaagaag ccgcttcaaa agcgagtgag 1152061 atcggctatc cggtgttaat ccgcccatct tacgttatcg gcggaatggg catgatcatt 1152121 gttgactcgc aagcccagct ttctcagctg ctgaatgatg aggacagcat gccatacccg 1152181 attttaattg atcagtatgt gtctggaaag gaagtcgaaa ttgatttgat ttccgacggc 1152241 gaggaagtct ttatcccgac atataccgag catattgaac gggcaggtgt ccattcaggg 1152301 gacagttttg ccattcttcc cggaccgtcc atcacgagcg ggctgcagca gggcatgaaa 1152361 gatgcggcac aaaaaattgc ccgaaaactt tcatttaaag gcatcatgaa cattcaattt 1152421 gtgatcgaca atggaaacat actcgttctt gaagtgaatc cgagagcgag ccgcacggtt 1152481 cctgtcgtca gcaaagtaat gggcgttccg atgattccgc tcgccacacg tctgctggcg 1152541 ggagcgtcct taaaagatct aaatccggca gttcaaaatc atcatggagt tgccgtgaag 1152601 ttccctgttt tttcttctca tgcgatccag gatgtggatg tcaagcttgg accggaaatg 1152661 aaatcaacgg gagaaggcat gtgtgtcgca tatgattcta acagcgcctt gaaaaaaatc 1152721 tatacaagag tctggagtca aaaaggaagc atttatttgc aaaacgttcc ggaagatgtg 1152781 aaggagttag cagaaaacgc aggttttaca atacatgaag gaacatttgc ctcatggatg 1152841 gaacaggaag gaaactcgct ccacattaat ctgagcggtt ctgaagaagc acgcaaagaa 1152901 cgtttggaag ccatgacgca cggcatcccc gtctttacag aagaagaaac tgtgcgggcg 1152961 tttttacaaa gcggttcagg ccatccgcag cctgtatctc tcaaagacct ctataaaaag 1153021 gaagtggcat catgcacaca gtgacgcaaa ccagtttata cggaaaagat ttattaacgt 1153081 taaaggacct tagtgaagaa gatataaacg ccttgctcgc agaagccggt gagctgaaac 1153141 aaaacaaaat tcagcctata ttccatggca aaaccttggc gatgattttt gaaaaatcat 1153201 caacgcggac ccgtgtttca tttgaagcgg gcatggcgca gctgggcggg agcgccctct 1153261 ttctaagcca gaaagatctg cagctggggc gcggtgagac tgtcgctgat acggcaaaag 1153321 tgctgtcagg ctatgtggat gccatcatga tccggacctt tgaacatgaa aaggtggagg 1153381 aacttgccaa agaagctgac attccggtga tcaatggact taccgataaa taccacccat 1153441 gccaggcgct ggcggatctc ttgacgatta aggagataaa agggaagctt aaaggcgtaa 1153501 aagtcgcgta catcggtgac ggaaataacg tggcgcactc cttgatgatc ggctgcgcga 1153561 aaatgggctg tgatatctcg atcgcttcac caaagggata tgaagtgtta gatgaagcag 1153621 ctgaagcggc aaagacatat gcacttcaat ccggctcttc tgtcacgctg acagatgatc 1153681 cgattgaagc tgtaaaagac gcggacgtga tttattctga tgtgtttaca agcatggggc 1153741 aggaagcgga agagcaagaa cgtcttgctg tctttgcgcc ttatcaggtg aatgcggcgc 1153801 tggtcagcca tgccaagcct gactatacat ttttacattg tctccctgcg catcgcgagg 1153861 aagaagtgac tgcggagatt attgacgggc cgaactctgc agtgttccag caggcggaaa 1153921 accgtcttca tgtgcaaaaa gcactgctga aggccatttt atataaaggg gaatcatcaa 1153981 aaaactgctg agccaaactc agcagttttt ttgatggcaa catattcaca gccgcttagg 1154041 cgcatactac agcaaaaagg aaaaggagga aaaacagtgg gacagcagca ccaattccgg 1154101 cccggacaga aagcgcctaa taacggtgtc tacgtagaaa tcggcgagac agggagcatg 1154161 gttaaaaacc ctcaaaaggt ccatctgtca gcaggggaaa tgttccccga aacatcaaac 1154221 cacaaccggc tgtggaccta caaaagaaag ccgtgaccac taaaaaaccc aaaacaataa 1154281 atgttttggg tttttggctt tttaatgctg gcttgcattt ttgttcatag gcatgatttc 1154341 tgctaaaacc atgattaaga catacagtac aacagcaatg acagatgatg ttttgaaatt 1154401 atacgtaacg ctgttcatgc ttgcaaccaa gtagcatgcc atatgtgata aaaggaacgt 1154461 ccaaataaag gcaataatat atcgcacgtt tccacctcgt ccttctcatt ctattctaaa 1154521 agttatcata ccatacaaaa agcgaagggg gaatccaatt ttagcagaaa gtgaggtgac 1154581 aaaagagtct gattcgtcac actttaatgg taaaatataa aacgtcaatc agtataatag 1154641 ccaaaaatgt aaaaggctag gactttacct tattcgtttc ttttctattt acataagata 1154701 gcgtgagatg aagtgtgaaa ggaggcgggc aagcgatggg aataacggaa agatactttc 1154761 aactgggaac ggagcataat gtcattcatc tgccctatcg cccgaacggc ttcggcatct 1154821 ttatcttggg ggacagaacc cactttgtcg gacatgattc aagcttttgg cagcagcatt 1154881 atggcagaaa tcagcttctg agcatgttga tgaatgaagg atacactctt tttaacagca 1154941 atctgttcgg aaggcattgg ggggcggaaa aagcagtcac ctatgccaaa cagctgatac 1155001 attctgtgct gaagcaggaa atcctcaatc cgaagattca tattttagca gaaggcatgg 1155061 gtgctctcgt ggccgatgaa ctgcttcgtt tttccccgga tcatatccgc tcagccgcaa 1155121 tgttgaatcc ttgtctcgat cttcaggcac attatgaatc ggaaaaagaa aataaatttt 1155181 tctataagca atttttgaaa gaagtatcga aaagctacgg aatttctgaa aaagaagcgg 1155241 aagcgattcg ttataaaaca attcaaagct acccgagcgg cgtaccggtt catatatggc 1155301 agcgtatgac cggagctcca tatccctaca gcgtacatgc ggaagttttc aaggaaaaac 1155361 agcaaaagca aggctcaccg gtcgacatga catttcattt atttgagcat ccaagcagaa 1155421 tttatgcatc aatttgcaaa ttctttcata gtcatgaaaa agaattatag agaatataat 1155481 gacaacagcc ttctcttttg cggaggctgt tttgttttgg gaaatgaaaa accggaaggg 1155541 cggcagatgc aatggaatca acgctgattg taggtgcgga cgaatttttc ggcctttcat 1155601 tatgtgagcg aatgatggat gaaggcatac atgttgacgt tgttctggcg gaaacagaag 1155661 ataaaatgag acaaatgtac ttagaagaaa gactcatgtg gcttgggaga aatgaactct 1155721 ttcgccagct tgaacacatt ggagaccaaa attatgatac aatttgtatc cagttcggaa 1155781 gttttttgcc tttagaccaa tatgattctc cttatatttt agtatatgaa gaagaccgaa 1155841 aagaatggga taaacgtgaa aaaacaggct cggaaaaaac cgtgatcctg ccgaaaatgt 1155901 acgggccatg gaaagaagaa acagaggaag acggctatta cacaaacgac gtggctgacg 1155961 agttgctgag attcctgtta gaaccaagcc gtcatagcaa agatcagctt tttgaattgc 1156021 aagtcacaga gaaaacctca aaagaagaag caaaaacaaa aattatcgag tggaaaagac 1156081 aattttcatc aattttcgac aaatattaag aaaaaccttc catgtttcga gttttctaga 1156141 tacaataaac gtataaaaat aatacatgtt atagcttgtc aaaaggagtt gaacatgact 1156201 tgatcacaag gcttgtcatg atcttttctg tcctcctttt attgagtgga tgtggacaaa 1156261 ctccgttcaa aggaaaaatt gagaaggtcg gcatgctctt tcctgatacg attaatgacc 1156321 tcgtatgggg cacaaaaggg tataaaggat tactgaatat acaatccaaa tacaatgtgg 1156381 acgtctatta taaagaaggc gttaaaacag aagaagatat cataaatgcg attgaggatt 1156441 ttcataagag gggcgtcaat ctgctctacg gccatgggag tgaatatgct gaggtgttta 1156501 acttggtcgg cgaagattat ccagatatgg aattcgtcat ttccaatgcg aaagcgaaag 1156561 ctgataatgt aacaagtgtc cattttagcg gggaagcaat gggctttttt ggaggaatga 1156621 ctgctgccca tatgtcgaaa acgaatcagg tcggtgtaat tgcttccttt acgtggcagc 1156681 ctgaggttga cggttttatc aaaggggcca agtatgaaaa tccggatata gaggtaaata 1156741 cgaaatatac ggatcattgg gatgatgata caacagcagt aaagctttat cagaaaatga 1156801 agaacgaagg cgcggatgtt gtgtatcccg ccggagacgg gtataatgtt cctgttattc 1156861 agcaaatcaa aaaagacggt ctttatgcca taggctacgt cacagatcaa tcggatctgg 1156921 gcgagaatac cgtattaacc agcacggtgc aaaatgtgga caaggcctat gaaatcattg 1156981 ctgaacaatt taataaaggc acccttgagg gcggcgatca ttactacgac ctgaacacgg 1157041 gagtcgttga gatgggaaca ttcagcccgc tcgtcgatca agactttcag caaagaatcg 1157101 ccaagctgat caaaacatac aacaaaacag gcgagctgcc aaaaaacgag taatggagtg 1157161 acgtcacatg cagcacgaaa aatcacttga attcttgcaa attgccatga aatatctccc 1157221 tgaagcgaaa gaacagcttg agaaatcagg cattgagctc tcaatggagg ccatccagcc 1157281 gtttatgaat ctatttacaa cggtaatggc ggaagcttat gagcttggca agtctgacgc 1157341 taaatctgaa acagaataag aagaagccac ttttttgaaa gtggcttttc acatgatttt 1157401 ctttttaata gcggagagca tgggcgcaag ctcctttaaa gcgggcttga tttgatcaag 1157461 agagttcata attgaaccga tttggtccat aatatgcatg taattaatcg tctcttcgtc 1157521 gtttgtctga gaaacctgag aaacttcctc ttgctgttcc tcctccttct cttctgttgg 1157581 ttttgctgca tcgccgaaca tcattcttga aaacacatcc aactgcatac gcctcctttc 1157641 catataccat actctatgag taagatgaac tgatagttta gacgaatata ttgccatgtg 1157701 aaaaaaaata ggatagaatt agtacctgat actaataatt gatcacaacc tgattgatct 1157761 tctaaattta agatataaag gagtcttccc taatgaaagc tggaatactt ggtgttggac 1157821 gttacattcc tgagaaggtt ttaacaaatc atgatcttga aaaaatggtt gaaacttctg 1157881 acgagtggat tcgtacaaga acaggaatag aagaaagaag aatcgcagca gatgatgtgt 1157941 tttcatcaca tatggctgtt gcagcagcga aaaatgcgct ggaacaagct gaagtggctg 1158001 ctgaggatct ggatatgatc ttggttgcaa ctgttacacc tgatcagtca ttccctacgg 1158061 tctcttgtat gattcaagaa caactcggcg cgaagaaagc gtgtgctatg gatatcagcg 1158121 cggcttgtgc gggcttcatg tacggggttg taaccggtaa acaatttatt gaatccggaa 1158181 cctacaagca tgttctagtt gttggtgtag agaagctctc aagcattacc gactgggaag 1158241 accgcaatac agccgttctg tttggagacg gagcaggcgc tgcggtagtc gggccagtca 1158301 gtgatgacag aggaatcctt tcatttgaac taggagccga cggcacaggc ggtcagcact 1158361 tgtatctgaa tgaaaaacga catacaatca tgaatggacg agaagttttc aaatttgcag 1158421 tccgccaaat gggagaatca tgcgtaaatg tcattgaaaa agccggactt tcaaaagagg 1158481 atgtcgactt tttgattccg catcaggcga acatccgtat catggaagct gctcgcgagc 1158541 gtttagagct tcctgtcgaa aagatgtcta aaactgttca taaatatgga aatacttctg 1158601 ccgcatccat tccgatctct cttgtagaag aattggaagc cggtaaaatc aaagacggcg 1158661 atgtggtcgt tatggtaggg ttcggcggag gactaacatg gggcgccatt gcaatccgct 1158721 ggggccgata aaaaaaggtg aggtgcacac aagatgacta aaaaaagagt agttgttaca 1158781 ggacttggag cattatctcc acttggcaac gacgtcgata caagttggaa taacgcaatc 1158841 aacggtgtgt ccggaatcgg tccgatcact cgtgttgacg ctgaagaata tccggcaaaa 1158901 gttgccgctg aattaaaaga ttttaatgtt gaagattata tggataaaaa agaagccaga 1158961 aaaatggacc gctttacaca atatgcggtt gtggctgcga aaatggcggt tgaagatgca 1159021 gatcttaaca ttaccgatga gatcgcgccg agagtcggtg tttgggtagg ctccggtatc 1159081 ggaggacttg aaacactaga gtctcaattt gaaatcttct taacaaaagg cccaagacgg 1159141 gtaagcccgt ttttcgtgcc aatgatgatt cctgacatgg cgacaggcca gatttctatt 1159201 gcattaggag caaaaggggt gaactcttgt acggttacag catgtgctac aggaacgaac 1159261 tccatcggtg acgcgtttaa ggttattcag cgcggtgatg cagacgtgat ggtcacaggc 1159321 ggaacagaag cgccgctgac aagaatgtca ttcgccggct ttagtgccaa caaagcgctg 1159381 tctactaatc cagatccgaa aacagcgagc cgcccgtttg ataaaaaccg tgatggcttt 1159441 gtcatggggg aaggtgcagg gattatcgtt cttgaagaac ttgagcatgc cctggcccgc 1159501 ggcgctaaaa tttacggaga aattgtcggc tacggctcaa ccggagacgc ttatcatatc 1159561 acagcgccgg cccaagacgg tgaaggcgga gcgagagcga tgcaagaagc cattaaagat 1159621 gcaggcattg cacctgaaga aattgattac atcaatgctc acgggacaag cacgtattac 1159681 aacgacaaat acgaaacaat ggcgattaag accgtttttg gcgagcatgc gcataaactt 1159741 gcggtaagct ctacaaaatc gatgacaggc cacctcttag gagcagccgg cggtattgaa 1159801 gccattttct ctatcctggc cattaaagaa ggcgtgattc cgccgacaat caatattcaa 1159861 acacctgacg aagaatgtga tttggattat gtgcctgatg aagcccgcag acaggaactt 1159921 aattatgttc tcagcaactc attaggattc ggcggacaca acgcaacatt aatctttaaa 1159981 aaatatcaat cataatcaag ccaaaccggc tgcccttaaa gggtagccgg ttttttttgt 1160041 gtgcatagga ttaaaagagg aggcgatcac atgagtgtag aacaaacata tagctggctc 1160101 aggaaggccg gttcaataga tgatttggcg cattacatta tcccgctttt ttcaggtgcg 1160161 gagaaaaaga actggaaggg cattctgggg catcttcagc atcatgggat gtttaaaaac 1160221 ataaaagagg gtattcagac ggtttccaag ctgaaggaaa aaggttttta cggacatatc 1160281 caaaaggaag aacagtacct caaaaacaaa tggcaaggtc ctgatgtacc aattgttacg 1160341 ctgccggttg atgaacgaaa caggagaatc cgtttagaat tcggatcaaa atcaggactc 1160401 gcctttcaag acaaaatgtt cctttttctt tcgtcagatt tagattttgg gtcggtatct 1160461 gcccttatga cgcatgagta tcatcacgtt tgccggttag gtcatctgac aaaagaggaa 1160521 aaggatgtca cattacttga tacaatcatc atggaagggc tggcggaata tgctgtttat 1160581 gagaggttcg gccgaagtca aacggctgaa tggacgactt ggtatacacc ggaacagctt 1160641 caggctttat atgaaaaaaa gattgcgccc catcgggata tcaaacggga taatcgatta 1160701 tttccccagc tgttattcgg caaaggatat cagccaaaaa tgcttggata cgcagttgga 1160761 ttcaatattg taaaaaaata tttaaccgcc agcaaggcaa gcaccgcaga cgggctgtcc 1160821 attcctgctg agaccttttt ggatgcaatg ctttaaaagg ataaaataat ggaatttcat 1160881 taataatatt acatttatcc taaaaaattc ttgattttgc aaaatgattg taataatata 1160941 caactataaa atttttcgat aattcaatat tatttattat ttctgaataa agggattgct 1161001 ttctcttgaa aacgtttgac aacaagaggg gggaaagggg agctagcatg agcacacttt 1161061 tagaagtgaa taatttaaag acttattttt tcaggaaaaa ggagccgatc cctgcggttg 1161121 acggagtcga ttttcacatc agcaaaggcg aaaccgtcgc gcttgtaggt gaatcgggct 1161181 ccggaaaaag cattacttct ttatcaatta tgggcctcgt ccaaagctca ggcggaaaaa 1161241 tcatggacgg ctctattaaa ctcgaagaca aagacctcac ctcattcact gaaaacgatt 1161301 attgcaaaat ccgcggtaac gaagtatcca tgatctttca ggaaccaatg acctccctta 1161361 atccggtgtt aacaatcgga gaacaaatta ccgaagtgct gatttaccat aaaaacatga 1161421 agaaaaaaga agcccgtcaa cgagctgttg aactcttgca gatggtcggt ttctcccggg 1161481 cggagcaaat tatgaaggag tacccgcatc ggctgtccgg cggtatgaga cagagggtga 1161541 tgattgccat cgcactgagc tgtaatccta aactgctcat tgctgatgaa ccaacgacag 1161601 cgctggacgt gacaatacaa gcccaggtgc tggagctcat gaaagatctc tgtcagaagt 1161661 tcaatacatc gattcttctc atcacacacg acttaggtgt cgtgtctgaa gctgccgata 1161721 gagtgattgt catgtactgc ggacaagtcg tagaaaacgc cactgttgat gacttatttt 1161781 tagaaccgct tcatccgtat acagaaggcc tgcttacgtc aattcctgtt atagatggag 1161841 agattgataa attaaatgcg attaaaggca gtgtgcctac accggataat ctgccgccgg 1161901 ggtgccgttt tgccccaagg tgcccgaaag ctatggataa gtgctggaca aatcagcctt 1161961 cgcttttgac acacaaaagc ggaagaacgg tgagatgctt tttatatgag gaagagggtg 1162021 ccgaacaatc atgacagcag ctaatcaaga aacaatctta gagcttcgtg acgtaaaaaa 1162081 atactttccg atccggtcag gcctttttca aagaaaagtc ggtgatgtaa aagcggtgga 1162141 tggtgtttca ttttcgttaa aaaaaggaga aacactcgga atcgttggag agtcgggctg 1162201 cggaaaatcg actgccggca gaacgatgat cagactgtac aaaccgacag agggccaaat 1162261 tctttttaaa gggcaggata tttccaatct gtcagaggag aagctgcgga agagtgtccg 1162321 caaaaatatt caaatggttt tccaagatcc atttgcttcg ttaaacccga gaaagaccct 1162381 gcgttccatc ataaaggagc cgtttaatac gcacaacatg tataccatgc gtgaacgaaa 1162441 cgaaaaagtt gaagagctgc ttgcaagagt agggcttcac ccgtcgtttg ccggccgtta 1162501 tccccatgag ttttcaggcg gccagcgtca gcggatcggc attgccagag cactcacttt 1162561 gaatccagag ctgatcattg cagatgagcc ggtttccgca cttgatgtat ccattcaggc 1162621 ccaagtgatt aacttgatgg aggaattaca ggaagaattt aatcttacgt atctatttat 1162681 ctctcatgat ctgagtgtcg tccgccatat cagcgacaga gtcggagtaa tgtatcttgg 1162741 caaaatgatg gaactgaccg gcaagcatga gctttatgac aacccgcttc acccatatac 1162801 ccaagcgctt ttatcctccg ttccggttac aagaaaaaga ggttctgtca aacgtgaacg 1162861 cattgtcctg aagggagaac tgcctagtcc ggccaacccg ccaaaaggct gcgtattcca 1162921 cacaagatgt cctgttgcaa aaccgatatg caaggaacaa ataccagaat ttaaagaagc 1162981 tgctcccagc cactttgtgg cttgtcacct ttatagctaa tgttgcccgc acagctttga 1163041 gagggggtat gcacactaca taaacaacag cctagaagaa cgaacatttc aagaggggga 1163101 atatctaatg aaaagacgga aaaccgcact gatgatgcta agtgtattga tggttctggc 1163161 catcttttta tcagcctgct cgggatcaaa atcaagcaac agcagcgcga aaaaatcagc 1163221 aggcaaaccg cagcaaggcg gggatttggt tgttggttca atcggagaac ccacactttt 1163281 taactctctg tattctaccg atgacgcaag tacggatatt gaaaatatgc tgtacagctt 1163341 tttaacgaaa acggatgaaa aactaaatgt gaaattgtca ctcgctgaaa gcattaaaga 1163401 attagacggc ggccttgcat atgatgtgaa aattaaaaaa ggcgttaagt ttcatgacgg 1163461 aaaagaactg actgcagacg acgtcgtatt tacgtacagt gtccctttaa gcaaagatta 1163521 caagggagaa cgcggttcaa catatgaaat gctgaaatcc gtagaaaaaa aggcgattac 1163581 gaagtcttgt ttaagctgaa atataaagac ggtaatttct acaacaatgc gttagacagc 1163641 acagctattc tgccgaaaca tattctcggt aatgttccga ttgctgattt agaagaaaat 1163701 gagtttaaca gaaagaaacc aatcggttca ggaccattta agtttaagga atggaagcag 1163761 ggccaatata ttaagctcga agcgaatgat gattactttg aaggaagacc gtatttagat 1163821 actgtgacgt ataaagtcat tcctgacgca aatgctgccg ttgctcagct gcaggcaggc 1163881 gatattaatt tctttaatgt gcccgccact gactacaaaa cggctgaaaa attcaacaac 1163941 ctaaaaatcg ttactgattt ggcattaagt tatgtgtaca tcgggtggaa tgaaaaaaat 1164001 gaattattca aggataaaaa ggttcgtcaa gcgctaacaa ccgctcttga ccgcgagtca 1164061 atcgtcagcc aagtattaga tggagacggc gaggtagctt acattccgga aagcccttta 1164121 tcttggaact atcctaaaga tatagatgtt ccgaaatttg agtacaacga gaaaaaagcg 1164181 aaacagatgc ttgcagaagc cggctggaaa gatacgaacg gtgacggcat tctggataaa 1164241 gacggaaaga aattctcgtt tacccttaaa acgaaccaag gaaacaaagt ccgtgaagac 1164301 atcgctgtcg tcgttcagga acagctgaaa aaaatcggca ttgaagtgaa aacccagatc 1164361 gttgaatgga gcgctctcgt tgaacaaatg aatcctccga attgggattt tgatgcaatg 1164421 gtcatgggat ggagtttatc cacattcccg gatcaatatg atattttcca ttcaagccag 1164481 attaaaaagg gtttgaacta cgtttggtat aaaaatgccg aagcggataa actcatgaaa 1164541 gatgcaaaat caatcagtga cagaaagcag tattcaaaag aatatgagca aatctatcaa 1164601 aaaattgcgg aagatcagcc gtatacgttc ttgtattatc ctaacaacca tatggcaatg 1164661 ccggaaaatc ttgaaggata caaatatcat ccgaaacgtg atttgtataa tattgaaaaa 1164721 tggtggcttg caaaataaat ttcccttaaa ggggagggag agcgttttct ccctcttctg 1164781 tttttaataa ggaaagtaaa gggggacaag tatatggctg catatattat cagaagaacc 1164841 ttaatgtcta tcccgatttt attgggaatt acgattttat catttgttat catgaaagcc 1164901 gcgcccggag atccgatgac attaatgatg gacccgaaaa tcagccaggc tgacagagag 1164961 cagtttattg aaaaatacgg tctgaatgat cctcagtacg ttcaatattt aaagtggcta 1165021 ggcaacatgg tgcagggtga tttcggaacg tctattgtca gaaaaggaac gcctgtttca 1165081 gaattgatta tggcaagact acccaatacg ctcctgctga tgctggtttc aacgattttg 1165141 gctcttatga tttctattcc gttcggtgtc ctgtcggcaa agcggccgta ttcaaaaatc 1165201 gactatggca ttacatttac ctcgtttata ggcctggcta ttccaaactt ttggtttgga 1165261 ttaattttga ttatggtgtt atcggtaaat ctcggctggt ttccaactgg gggtgtcgag 1165321 acactgaata ccgaattcaa tatatttgac cggattcatc atttaattct gcctgcattc 1165381 gttctagcta cagctgacat ggccggactg acgagataca cgagatccaa tatgcttgat 1165441 gtattaaatc aagattatat tcgcacagcg agagcaaaag gatttaaaga gaacagagtg 1165501 ctatttaaac atggattgag gaatgcatta ttacccgtca ttacaatttt cggtttgatg 1165561 attccttcat ttatcggcgg atctgtcgtt gtcgaacaaa ttttcacttg gccgggatta 1165621 ggaaagctgt ttgtcgattc agcattccag cgcgattatc cggttatcat ggcaatgact 1165681 gtgatctcgg cggttcttgt cgttgtcgga aacctcattg cagacatcct ttacgcgatt 1165741 gttgatccgc ggatcgaata ttaaaaggag ggaaacagag atgtcagagc tgcaaacaac 1165801 tccctcgccg gagatcaggc tgaaagaaaa tatttcgaaa aagccagaaa caatgacaaa 1165861 gattttctgg gaaaaattct cgaaaaacaa actggccatt ttaggtgccg ttattctttt 1165921 tatcattatt atgtctgctg ttttcgcccc tttaattgca ccttatcccc aagagcagca 1165981 aagcctgctt gataaatata aggcgccggg ccttgaacat ctgatgggaa cggataaatt 1166041 tggacgtgat attttcagcc ggatcctata tggagcgcgt gtctctttat tggttggatt 1166101 tgcgtccgta gtcggttcga ttttgatcgg aacggtttta ggagcattag ccggatattt 1166161 cagaggaata gtggatgctg tcattatgcg tgtagttgac attgtgttat ccattcctga 1166221 tattttcttg ttgatcacgc tggtcaccat cttcaagccg ggtgtggaca aattgatttt 1166281 aattttctgt ctcacaggat ggaccacaac agcacgatta gtaaggggag aattcttgtc 1166341 gctccgttca agggaatatg ttcttgctgc taaaacaatt ggaacaaaaa cgcacaaaat 1166401 tattttttct catatcctgc ccaatgcgtt agggccgatt atcgtgtcag ctacgctgaa 1166461 agttgggtct gttattctag ctgaatcggc gctaagctac ttgggctttg gaatccagcc 1166521 gccaatcgct agctggggga acatgcttca agacgcacag aatttcacag taatgattca 1166581 agcatggtgg tacccgttat ttcccgggct atttatttta atgaccgttt tatgcttcaa 1166641 ctttgtcggt gatggcctgc gggatgcgct tgacccgaaa aatattaaat aaaaatgaat 1166701 atcatatctg ttataaaata tcaccaaatc agaaaaaagc aggtctcctt tagtcagaaa 1166761 atatacaaag agatctgctt tttatgattc ttacataaac ccagtgattc cagatttcct 1166821 caatctcttt ggaataattt ctctatccct tgcctatact gtggacaaca gtttttataa 1166881 aagtgagggg ttagagatgt tatttcttca tgatgtgtgg gtcaattggt ttgaagggga 1166941 agaaaatggc tacaatgtat gccactttca cgaatggcgc aaggaagata cggttgagct 1167001 tttggatcag gtgccgctgt taagggtgcc gtcagtactg tttcattaca tagaaaacga 1167061 tttgtcagag cttccgaaag gtttgcttga agacgtacat cagaaatcgt acattcgaaa 1167121 aaatcatgag cggacaaagc ttgagtattg ttttgtcgta acagacggaa tcggcatttt 1167181 agctgttgac acgatcggct acacgatccc tgtcagaaaa agccgtctaa tcccaagaca 1167241 ggagcagctc gtttatgaaa tggtaaaaga tgtagagcct gaaacatatg aatttgagcc 1167301 aaagaagctg gaatcctcca aggaatatca catcttatca ttagcaccag aacatgtcag 1167361 aggactgaca agaaaagaac ggcaaattaa gcagctgatg tttatggcgc ttgaccaatt 1167421 aaaagggctg aaaaaccgag cggaaattgg ctactggtac acagagtgga atccgcatat 1167481 gtatgaacaa atcaaaagga tgagctttga agagatttgg gacatgctgt ataacgaaac 1167541 aattgaaggc tggtcggaca aacacctagc tttttgcgaa aacctaataa aaggacagcc 1167601 ttttttcgaa aagctttggg aaatggaaaa cgaatcaaag gtcaactgaa aaaaaccgct 1167661 ctttgcaaag agcggttttt tgattagcgt ctttttcttc caagacccat ggcattctcc 1167721 atttttttca gcattttgtt tgctgtccga ttcgctcgtt ccgcgccttc atcaagaatc 1167781 cggtctaatt cttcagattc tatcagctcg taatagcggt cctggatcgg ttttaatgcg 1167841 ttcactacga cttctgccaa atcaccttta aactcgccgt agccttttcc ttcgtacttt 1167901 gcttcaagct cttcaattgt cgtattgccg aggattgaat aaattgtaag aaggttggaa 1167961 acgcccggtt tgttttcctt atcaaatttg acaatgcctt cagaatccgt tactgcgctt 1168021 ttgattttct tttcaagctg cttcggctca tccagcaatg taatataagc tttctgattc 1168081 ggatcagatt tgctcatttt cttcagcgga tcattcagag acatgatacg tgcaccgact 1168141 tttggaattt tcacttccgg aatcgtaaag atgtcgttgt attttttgtt gaagcgttct 1168201 gcaagattcc gcgtcagctc aaggtgctgc ttttgatcct cgccgacagg tacaagatcc 1168261 gttccgtaca gcagaatatc agcggccatc agcggcggat atgttaacag gccggagacg 1168321 acagcttcat tgcctttgga tttgtcctta aattgagtca tccgctcaag ctcgccgata 1168381 taggcgacac actgcatcat ccatccggcc tgcgcatgtg cggggacctc tgactgaata 1168441 aacaatgttg ctttttctgg atcaagtccg acagctaagt aaagcgccgc gagattgcgg 1168501 atattctttc taagctcaag ccggtcttga ggaacagtta tcgcatgctg atcgacgatg 1168561 caaaaatagc tgttataatc atgctgcagt tcgacaaact gcttcattgc accgatatag 1168621 ttgccgagcg tcactgagcc gcttggctga atgcctgaaa aaatcgtttg tttcatgaaa 1168681 acatcaacct catttcttaa aacataataa aaaaggctca ttcttcccct gtaaaaaagg 1168741 gacgaatgaa ccgtggtacc accctgatta ttccattaaa atggaatcac tctgacgttt 1168801 gtaacggaga ctgctccggc tgagcctact tttttccagt tcggtcagct gctccaaagt 1168861 ccattccaca ttgcccgtta tctgctccca gcaccgcaga ctctcttcaa acaggtgaaa 1168921 cgtgtactac tctttttcat agcaagcttt tcttttgatt gcttcattat aaatcaatta 1168981 taaccaattg tcatcatgaa aaaacattct tttttccagt aaaattgtaa taatataaat 1169041 aacacgagtg ctgtaaaatc cttaaatgat aactgctatc agcgtaaaaa caggcagata 1169101 ttatatgtaa aaagcaatat gggcagaaaa cacatgaaaa agtttttaat caatttatgc 1169161 tttaaatggt agaaggatat tatgttcatg gaagaaaaac taacgaagtt taaatatttt 1169221 aaattgataa aataatattg caataaatta tttgtttcat tataatgaac ttgttcactc 1169281 tattgttaca gcttttttac aaaaataatc agaaaagacg gaacagaata aaagttgtgg 1169341 aaactcaggt tcatttgtct gatatttctg aggatttagc cgtaaggagc tgaaaattat 1169401 tattaggggg tttgcgaata tgaaaaaacg ttggtcgatt gtcacgttga tgctcatttt 1169461 cactctcgtg ctgagcgcgt gcggctttgg cggcagcgga tcaaacggtg aagggaaaaa 1169521 ggacagtaaa ggaaagacga cacttaacat taatattaaa actgagccgt tctccttaca 1169581 tccgggattg gcaaatgatt cagtatcagg cggtgttatc cgtcagactt ttgaaggatt 1169641 gacacgtatc aatgcagatg gtgagcctga agaaggcatg gcttctaaaa ttgaaacgag 1169701 caaggacgga aagacatata catttaccat tcgtgatggt gtgaaatggt ctaatggaga 1169761 ccctgtaact gcacaagatt ttgaatatgc ttggaaatgg gcgcttgacc ctaataatga 1169821 atcacaatac gcttaccagc tctactacat aaaaggtgct gaagcggcga ataccggaaa 1169881 aggcagccta gacgatgtgg cagtaaaagc tgtgaatgac aaaacgctga aggttgaatt 1169941 aaataacccg actccatatt tcactgaatt aactgcgttc tatacgtata tgccgatcaa 1170001 taagaaaatt gcagagaaaa ataaaaagtg gaatacaaat gccggagatg attatgtatc 1170061 aaacgggccg ttcaaaatga cggcatggaa acacagcggc tctattactc tcgaaaaaaa 1170121 tgaccagtat tgggataaag acaaagtcaa actgaagaaa atcgatatgg ttatgatcaa 1170181 caataacaat acggaactaa aaaaattcca agctggcgaa cttgattggg ccggtatgcc 1170241 gctcggacag cttccgacag aatccctgcc gaccctgaaa aaagacggtt ctttacatgt 1170301 tgagccgatt gcaggagtgt attggtacaa attcaacact gaagctaagc cattagacaa 1170361 cgtcaatatc cgtaaagctt taacatattc gcttgaccgt cagtcgattg ttaaaaacgt 1170421 tacgcaagga gagcaaatcc cggcaatggc tgcagtgccg cctacaatga agggatttga 1170481 ggataacaaa gaaggatact tcaaagacaa tgatgtcaaa acagcaaaag aataccttga 1170541 aaaaggccta aaagaaatgg gcttaagcaa ggcatctgat ttgccaaaaa tcaaattgtc 1170601 ttacaacact gatgacgcac acgcgaaaat cgctcaagca gtacaagaaa tgtggaagaa 1170661 aaatttaggc gttgatgttg agcttgataa ctcagagtgg aatgtctata ttgataagct 1170721 ccacagccaa gattatcaaa tcggccgtat gggctggctc ggcgacttca atgatcctat 1170781 caacttcctt gaattgttcc gcgacaaaaa cggaggaaat aacgatacag gctgggaaaa 1170841 tccagaattc aaaaagcttc tgaatcagtc acaaactgaa acagataaaa caaaacgtgc 1170901 agagctgctg aaaaaagcag aaggtatttt cattgatgaa atgccggttg ccccaatcta 1170961 tttctatact gatacttggg tacaggatga aaacctaaaa ggtgttatca tgccaggtac 1171021 tggtgaggtt tatttcagaa acgcatattt taaataaggc tacgtctgaa aataaaagac 1171081 ctcaaggtat atggggagaa aagccccata tacctttctt actgatggag tataaaaatg 1171141 taaaaaccat ggaggtgttc ccccttgcta aaatatatcg gaagacgctt agtctatatg 1171201 attatcacac tatttgtgat tgtaactgtg acattcttct taatgcaagc agcaccgggc 1171261 gggccatttt caggtgagaa aaagcttccg cctgaaattg aagcaaattt aaatgcgcat 1171321 tatggcttgg acaagccgct gtttgtacaa tatgtcagtt atttgaaatc agttgcaatg 1171381 tgggatttcg gaccgtcatt taaatataaa ggtcagagtg ttaacgacct gatcagttca 1171441 ggtttccccg tttcatttac tcttggagca gaagctattc tcctcgcttt agcgttaggt 1171501 gtattgtttg gggtcattgc agccctttac cataataagt ggcaggatta taccgtcgcg 1171561 attttaacga tatttggtat ttcggttccg agctttatca tggcggctgt tctgcaatat 1171621 gtgttctcca tgaagcttgg gctgtttccg gtcgcggggt gggattcctg ggcatacacc 1171681 tttttgcctt ccatcgcact tgcttccatg ccgatggcgt ttattgccag actttcccgt 1171741 tcaagcatga tcgaagtgtt aaacagtgat tatatccgca cagcgaaagc gaaagggctt 1171801 tcccgcccag cggttacagt gcggcacgcc attcgaaacg cacttttgcc ggttgttaca 1171861 tatatgggcc cgatggccgc acaggtctta acggggagct tcattattga aaccattttt 1171921 gggattccgg ggcttggtgc acacttcgtc aacagtatta caaaccgtga ttatacggtc 1171981 attatgggtg taacggtgtt cttcagtgtc atcttgctat tgtgtgtatt aatcgtagat 1172041 gtgttatacg gcattattga tccaagaatc aagctttcca aagcaaagaa aggagcctag 1172101 gccatgcaga acattccaaa aaacatgttt gaaccagccg cagcgaatgc cggcgatgca 1172161 gaaaaaataa gtaaaaagag cctttccctc tggaaagatg cgatgcttcg cttccgcagc 1172221 aataagcttg caatggtcgg gcttatcatt atcgtactta ttatccttat ggcaattttt 1172281 gcgccgatgt tctcaaggta tgattattca actactaatc tcttaaatgc ggataagccg 1172341 ccttcaaaag atcactggtt cggaacagat gatcttggac gggacatttt cgtccgtaca 1172401 tgggtagggg cgcgaatctc aatctttatc ggtgttgcag ctgctgttct cgatttgctg 1172461 atcggcgtca tttgggggag catttcaggc ttccgcggag gaagaacaga tgaaatcatg 1172521 atgcgtatcg ctgatatcct ttgggcagtt ccttcattat taatggttat cttactgatg 1172581 gttgttcttc cgaaaggtct atttacgatt attattgcca tgacgattac aggctggatt 1172641 aatatggcca gaatcgtgcg cggacaagtg ctgcagctga agaatcagga gtatgtgctt 1172701 gcttcacaga cactgggtgc aaaaacatcc cgtcttctat ttaaacatat cgtgccaaac 1172761 gcaatgggtt ctattttggt cacgatgaca ctgacagttc ctactgcgat ttttacagaa 1172821 gcctttttaa gctatttggg acttggtgtt ccggctccgc tggcaagctg gggaacgatg 1172881 gcttctgacg gattgcctgc attgacctat tatccgtggc gtttattctt ccctgccgga 1172941 tttatctgca ttacaatgtt tggttttaac gttgtcggcg acggattaag agacgcattg 1173001 gatcctaagt tacgtaaata agggagtgat acgggtgaca cgcctattag aagtaaaaga 1173061 tttagcaatt tcatttaaaa catatggcgg agaggtccag gcgatccgcg gagtgaattt 1173121 ccatctggat aaaggggaga cgctggccat tgttggagaa tcaggttccg gaaaaagtgt 1173181 aacctctcaa gcgattatga agctgattcc aatgcctccg ggttatttca aacgcggtga 1173241 gatcctgttt gaaggaaagg atctggtgcc gctgtccgaa aaagaaatgc aaaatgtccg 1173301 gggaaaagag atcggcatga tattccaaga tccgatgacc tctttaaatc caacgatgaa 1173361 ggtcggtaaa caaattacgg aagtgctttt taaacacgaa aagatctcga aggaagcggc 1173421 taaaaaacgc gcggttgaac tgctggaatt agtcggtatc ccaatgccgg aaaagcgggt 1173481 gaaccaattt ccgcatgaat tttcaggcgg gatgagacag agggttgtca ttgccatggc 1173541 gcttgcagcg aatccgaaac ttctgatcgc cgatgagccg acaactgctc ttgatgtaac 1173601 gattcaagcg caaattttgg aattaatgaa ggatttgcaa aagaaaattg acacgtccat 1173661 catctttatc acacacgatc ttggtgttgt ggctaacgtt gctgaccggg tcgctgtcat 1173721 gtacgcggga cagattgtag aaactggtac ggtagacgaa atcttctacg acccgagaca 1173781 tccgtacact tgggggcttc ttgcatccat gccgacactg gaaagttcag gagaggaaga 1173841 gctgactgca attccgggca cgccgcctga tttgacaaac ccgccaaaag gagatgcttt 1173901 tgccctgcgg agctcttacg cgatgaaaat cgattttgaa caggagccgc caatgtttaa 1173961 ggtatccgat actcattatg taaaatcgtg gctgcttcat cctgacgcgc caaaggtaga 1174021 gccgcctgaa gcggtaaaag cgaaaatgcg taaactggca aacacgtttg aaaaacctgt 1174081 cttagtgaga gaagttgaat gaattgactg aaaaactatt agaaatcaaa catttaaaac 1174141 agcactttgt cacgccgagg ggaacggtta aggctgtaga tgatttatca tttgatatct 1174201 ataaaggtga aacattaggg ctggttggtg aatctggctg cggtaaatcg acaacaggcc 1174261 gaagcattat caggctgtac gaagcaaccg atggtgaggt gctgttcaac ggcgaaaatg 1174321 tgcacgggag aaaatcgcgg aaaaagctgc tggaattcaa ccgcaaaatg cagatgattt 1174381 tccaagaccc ctatgcatcc ctgaatccga gaatgacagt tgctgatatt attgctgaag 1174441 gccttgatat tcataagctg gcaaaaacga aaaaagagcg gatgcagcga gttcatgaac 1174501 tattggaaac agtgggattg aacaaggaac acgcgaaccg ctatcctcat gaattttccg 1174561 gcggccagcg ccaaagaatc gggattgcca gagcgcttgc tgttgatccg gaattcatta 1174621 tcgcggatga gccgatttcc gctttggatg tatccattca agcgcaggtc gtgaatttaa 1174681 tgaaagaact gcaaaaagaa aaagggctca catacctgtt tattgcccac gatttatcga 1174741 tggtcaaata catcagtgac cgcattggcg tcatgtattt cgggaaactg gttgagcttg 1174801 cgccggcaga tgagctttat gaaaatccgc ttcacccata tacaaaatca ttgctttctg 1174861 cgattccgct tcctgatccg gactatgaga gaaatcgcgt tcgccagaaa tatgatccgt 1174921 ctgtccatca attaaaggat ggggaaacga tggaattccg tgaagtcaaa ccgggacatt 1174981 ttgtgatgtg cacggaagcc gaatttaaag ctttttcatg attcatcaat ccttcaagag 1175041 atttctcttg aaggattttt ttgcgtcttc atagaaagtg agaatgataa catttacaat 1175101 tagaggaaaa agcggaggcg aaatacgatt caatttctgc ataacaaaaa tgtttttgcg 1175161 ctattgctgt ctcaatcttt tcaatcttta gcaggagtcc tcgtcacaat cgttttaatg 1175221 gtccggatct atcaaatgac tgactccgtt tttttggcgg gccttatttt atcgttcatg 1175281 tcgtttgcga gtatagcagc aagcttttgc gtctctccgg tgcttcgcat tctcggtttt 1175341 aaaaaggtgc ttgcgggagc gaatctgctg agagcggtct ttattatact gatggcatac 1175401 agcgtcactc atcacggaca ggcattcttt tggattacgc tgctgtttgt gttttgtttt 1175461 tccttcgcgg gcgctttttt tcagccggca agatttgcgc tgctgccgat tattgttcca 1175521 aagaagcaat atgtaaaagc gaatggtgtg atctccctct cgaatcaatt gttcttaaca 1175581 gcaggctggg gccttggagg ccttctgacg tacgccgtcc cttttgaact cgttgtcggc 1175641 gctgccattt gcctgtttgt tctatcggga gcttccatca gtgtgctgca tgtaaatgaa 1175701 gaagaggctg caggaactgc tgaaacagca tctgtcagaa gtatatggaa ggatttaatg 1175761 atcatcccta ttgtaagaga cattactgta atggacatgt tagaagcttt ggcgggttcc 1175821 gtatggtcat ctgctattct cctcgcattt actgcggctg ttttgcatga aacagaggtg 1175881 tggtggggga tgtttaacgc ttcctatttt ataggcgcaa ttgtcggcag tgtgattgct 1175941 attcgttttt cttctttttt tgagcggaat atgggctatg ccattatgtt cagctcgctt 1176001 gtaatgtcgg cgctgaccct tttgttttca ttttctccag tcccattttt atgcgctctg 1176061 gcttgtgctg caatggggcc tttttatcag gtgcgtgata tttgccagga aaccatgctg 1176121 caggaagtta ttcccgagca gaaacgaatc ggaatcatgg ctgcaaaaaa tgcgattttg 1176181 actccttggt caggcgtcac ctactccatt atggggctag tggctgatgc tgctggtgcg 1176241 aaaatagctt ttatcgcggc tgctgcatta tatatcatga catttctgat tgcactggcg 1176301 cagccccgtc tggttcatta caggcgagaa aatcgagttc aatgagaaac acttcaaaat 1176361 gaacggagca gctggctccg ttttgctgaa aaaaaaatga aaccatggcg gaagttcgca 1176421 cgtctttata gatgtaaggc tgtttaaaca agaagaaatg gggtatatct aaaagtatga 1176481 agacaacgaa ctcataagga gcaaatcaat gaactggtat gaaaagctta gcgagtactt 1176541 tccaattgaa gaaatgaaat caaaagcgca tatggaagct cttctgaaag agcgaagcga 1176601 tatttatcat aaagatgaag gcaaacatca tattttaatg tttgcggaat tcgattcttt 1176661 tatcttcgtt gattatctgt atgtgtctaa ggatgcaaga gggcaggggc ttggcggcaa 1176721 attgatcgcg aagctgaaaa agaaaaataa gcccatattg ctcgaggtgg aacctgtgga 1176781 tgaagatgat actgatacag aaaaacgcct gaggttttat caaagagagc atttcaagca 1176841 tgctcagtca attgggtacc ggcgccggtc attggctacg aatgaagtaa acaagatgga 1176901 gattctgtac tggtcaccaa aaacagaatc agaagaagaa attcttgaag ccatgaaaca 1176961 gacatatgaa aacattcata cttataaaga tgagaaatgg tacggagaat cgtacgaaaa 1177021 aacggatgag gtcttggaaa tcatcgatga agaaaaacaa aaaaatattt tcgatcagtt 1177081 aagctaattg agaataagaa catatcatga acattaaaaa tttgctggat tgacacattt 1177141 ttttcttagg atactgttca cacttacttt tttatagtat aatacctgta aagattcctt 1177201 ttttagagta atttcaattt aagaataaaa tagatgttca tcctactaat tagaggagtg 1177261 aagatgaatg gttacactat acacatcacc aagctgtact tcatgcagaa aggcgagagc 1177321 gtggctcgag gagcacgaga ttccatttgt agaaagaaac attttctctg aacctttatc 1177381 aattgatgaa ataaaacaaa ttcttcgaat gactgaggac ggaacagatg aaatcatctc 1177441 aacccgttca aaagtattcc aaaaactgaa tgtgaacgtt gaatctatgc cgctgcaaga 1177501 tttgtaccgc ttgatcaacg agcatccagg tttgcttcgc cgtccgatca tcattgacga 1177561 aaaacgtttg caggtcggat ataacgaaga cgaaatcaga cgtttcctgc caagaaaagt 1177621 tcgctctttc caattaagag aagcacagcg tttggcaaac taatagatcg tatcatcaaa 1177681 agaaggctga gtcatcagcc ttcttttatt tttcaacctg ctggtaataa atgctcgcaa 1177741 ggatgacaaa cgcaaccgtc aaaatgggga ggagcgtttc gactgtgccg tgctgcgcca 1177801 taaaaagcga cagctttttg tctctgacaa tcatttctcc gccagtataa gcaagcagcc 1177861 cgcttcccgc gtaaatcaga agcggtattt tctctagtgc aatatggatg agtttgctgc 1177921 cccaaataat aaccggaacc gatacacaca atcctataac aacgagagaa aactcaccgt 1177981 gtgaagctcc cgcaactgcg atgacgttgt ccagcgacat aaagagatct gcaagcacaa 1178041 tcgttcgtat cgctctccac agggaggtgc tgcttttaat gtgtttcgtg tctttttttt 1178101 caatcagcag ctgatatcct aaatacagca ggaaaattcc gccggcgcac tgcaagaacg 1178161 gaatgttcaa aagatatact gctgcacttg ttaatccgat tctcatggca acggcaataa 1178221 atgttccgag aataatggct tgctgtcttt gcttgtccgg caaatgtctg ctggccatgg 1178281 caataacaac cgcgttatct ccgccgagga tcaggtcaat cccaacaatg acgagcagag 1178341 aaatcagata gtcatgctcc atgaagcggc acctcgcttt cagtccttcg cttgtactac 1178401 tactatatga gacaggtcat attttatgat atcagccgcc tgatctgccg ttttttaggc 1178461 aaaggtgcat ttttatttct tttgtgactg ttttatcata aaatagaaat acaaaggaat 1178521 tcacactggc cttggttaag gttaagatgt ggacggaatg ggtaaagtgt agtaaagtac 1178581 aattaatcgg gagcttagat gtcccttcaa catcttatat agaagggaag gttggcaaat 1178641 ggaaattgaa agaattaacg agcatacagt aaaattttat atgtcttacg gagatattga 1178701 agatcgcggt tttgacagag aagaaatttg gtataaccgt gagcgcagtg aagaactttt 1178761 ctgggaagtc atggatgaag ttcatgaaga agaggaattc gctgtggaag gcccactttg 1178821 gattcaagtt caggcactgg acaaaggatt agaaatcatc gtcacaaaag cccagctttc 1178881 caaagacgga caaaagctcg aactgccgat tcctgaggat aaaaagcaag aaccagcatc 1178941 tgaggatctt gacgccttgc tggatgattt ccagaaagaa gagcaagccg tcaatcagga 1179001 agagaaggag caaaagcttc aatttgtctt gcgatttggc gattttgagg atgttatttc 1179061 tctatctaaa ttgaacgtta acggaagcaa aacgacttta tattcgtttg agaaccgata 1179121 ttatttatat gtagattttt gcaatatgac tgatgaagag gttgaaaatc agctaagcat 1179181 cctgctggag tacgcaactg aatcctcaat cagcatacac cgtcttgaag agtacggcaa 1179241 gctgattatt tcagagcatg ctctagaaac gataaaaaaa cactttgcat catagcaaac 1179301 cgatttcctt ccggaaatcg gtttttttta tgcacgaaaa tgccatttta gagatgtgaa 1179361 aaatcaaaaa catatagaca agcagaaaat acagcgaaca ggagttgatc atcttttcca 1179421 gaaagtatac ttcatctgga aaggagagat gacaattgtt tagtgctgtg actgaagacg 1179481 gccaaatgtt tcaccttcta ggcgctcagc aaaaccagaa attaaagcgg agacggttct 1179541 tctgtccggt atgcggggga gagctagctg tgaagctcgg acttcaaaaa gcgccgcatt 1179601 ttgcccataa acagaacaag tcctgcgcca tagacatcga gccggaaagc gcctaccact 1179661 tagaaggaaa aagacagctg tatgtatggc tgaaaacgca acgggcttca ccaatattgg 1179721 agccgtatat aaggacaatc aaccaaagac cggacgtcat ggcaagaatc aaggagcata 1179781 tgcttgctgt tgaatatcaa tgcgccacta tcgctccaga tgtctttcaa aagcggacag 1179841 agggcttcaa acaagaagga atcatcccgc agtggattat gggatacagc cgcttaaaac 1179901 ggactgcttc gtccttttat cagctttcaa cttttcattg gcagtttatc aatgcaagtc 1179961 catacagaga actgatatgt tattgtcctg aaaggcgttc ttttctccgg ctcagccaca 1180021 tcattccatt ctacacaaac cattcttatt cctcagtcca aacgatccct atccatcggg 1180081 caggtgcagg cgatcttttt ttcactgaac cgaaaccctc aattcaatat tcaggctgga 1180141 cgaaagcgat tcaccgtttt cgccataaac cccatcggtt taactcaaag gaaacaaatc 1180201 gccttaggct gctgttttat gagaaacgac agacgccttt ttcttttctg ccgactgaag 1180261 tgtttgttcc tgttagaaaa ggggcagttt ttaagagtcc ggtttttgtg tggcaggggt 1180321 ttctttattt gtttatgacg gatcttggag gtaaacgtgc gccaattcgt ttttcagccg 1180381 ttttgcagca gtgcaaactg cacattcata ataagaacat tgcactcagg tccgaatgca 1180441 gcgaagagtg tctttcagaa gcggttaaac agtatattga ttttttgtgc aagaagggat 1180501 ttttaaggga gactcagaaa gaagtatatg tgctgaatca gcctgcagga ggcatacact 1180561 ccatgcagga tctcatagaa agagaccgca gctgttttat agaatgagtt tgtcttattt 1180621 ggctcaccct aagacaaagg tggtgggcag gctgtgaaag gcacaaaagg aaaggttttt 1180681 cgtgttttta ctgctttttt ggcattcgtt ctcttcatta ctgcatatga tttgacaaaa 1180741 ggcagtgaaa aaccggaaga tattcacaac acaagtttat tgagaaacag ctgttttttc 1180801 aattggcttg aatcaaagaa gacgaggggg atcaccatgg ctgaggaaaa aaaagcaaac 1180861 caactgcctg acagaagtga ggtaaaggca gaagacacat ggagacttga ggatattttt 1180921 cctagtgatg aggcctggaa taaagaattt caagctgtaa aagaattaat tccgaattta 1180981 tctaagtata aaggaaagct ggcagattca gctgatcatt tatacgaggc tcttacgtat 1181041 caagataaag tgatggagcg gctaggtagg ctgtacacat atgcgcatat gcgctctgac 1181101 caggatactg ggaactcctt ttaccagggg ctgaatgaca aggcgggaaa cctgtataca 1181161 caggccgcaa gcgcgacagc ttatttggtt ccggagattt tatccataga agaagacaaa 1181221 ctgcagcagt tcattcttga aaaagaagaa ttgaagctgt actctcatgc gattgaggag 1181281 attacaaagg aacgtccgca tgtgctgagc gagaaggaag aggcgctgct tgctgaagcc 1181341 tccgaggtac tggggtcatc ttcaaataca ttcagcgtgt taaataacgc agatataacg 1181401 tttccatcca ttaaagacga agatgggaat gaaaaacaga tcactcacgg caactttatt 1181461 aatttcttgg aaagtgaaaa ccgtgaagtc cgcaaaaatg cgtttgacgc agtgtataaa 1181521 acgtacggac aatataaaaa cacaatggcc acgacgctaa gcggcactgt gaaaaaggac 1181581 aacttctacg cgagagtgaa aaagtacaag tccgcgcgtg aggctgcgct ttctaacaac 1181641 agtattcctg aggaagtata cgataacctt gttaagacga ttaataagca tttgccgctc 1181701 ctgcaccgct atattgcgct aagaaagaaa gtgcttgagc ttgatgaagt gcatatctat 1181761 gacctgtata caccgcttgt gaaagatgct gggatgaagg tgacatacga ggaagccaaa 1181821 gattacatgc tgaaaggcct cgcaccttta ggggaagaat atgcctctat cctaaaagaa 1181881 ggactggaaa accgctgggt ggacgtttac gaaaataaag gcaaacgcaa tggggcttat 1181941 tcatcaggag cttacggcac gaatccgtat attttgatga actggcataa taacgtcaat 1182001 aatctcttta cgctcgtgca cgagtttgga cattccgtac acagctacta tacgagaaag 1182061 caccagcctt atccatacgg caattacagc atctttgtcg cggaagttgc ctctacgaca 1182121 aatgaagcgc tccttggcga atatttgctg aacaatttag aggatgaaaa acagcgctta 1182181 tatattctca accatatgct tgagggcttc aggggaacgg tcttcagaca aacgatgttc 1182241 gctgaatttg aacatctgat tcatacaaag gcgcaagaag gcgagccgct tacacctgag 1182301 cttctgacaa atgtctatta cgacctgaat aaaaagtatt ttggagacgg catggtgatt 1182361 gataaggaaa tcggccttga atggtcgcgt attccgcact tctattacaa ttactatgtg 1182421 tatcagtatg cgacaggtta cagcgctgcc caagcattaa gcagccagat tttgaaggaa 1182481 ggaaagccgg cggttgaccg ttatattgac ttcctgaaag cgggaagctc acaatacccg 1182541 attgatgtcc tgaaaaaagc gggtgttgat atgacgtctc cagagccaat cgaagccgcg 1182601 tgcaaaatgt ttgaagaaaa acttgatgaa atggaagagc tgctgatgaa agtcaagcag 1182661 tcttaaaaaa gtaagcctgt gcggaaatga cgcacaggct tttttaaaac cctttaaagg 1182721 ttttccggtg attcaagcgg tagagggtaa acaaaataga cagaaacagc agaggagagg 1182781 taatataaag cggcagcata tgcatcatgc ctaagatatt caagcagaaa aaaacagcaa 1182841 tgcacacaat tgagatcaaa gtagacatca tggcggtcct cctcgtcctt tttccttata 1182901 aggatatgag tgaatgcact tcgttatgtt ttgtgacaaa aatatgaaca ttaagcatag 1182961 aggttgtcaa aagtcgacat cttttgttat cataaggatg tgaaattgat cacaaacaaa 1183021 cattacccct ttgtttgacc gtgaaaaatt tctcccatcc cctttgttgt cgttaagaca 1183081 tatgaaaccg cgcttatccc ggcgcggttt ctttagtgct aaaaatggaa cgtacgtttg 1183141 gttatggcat aaaaaaacag cctcaagcat atgcacgcct gcggctattt ttcacatgat 1183201 tgatattcat cagaataagt gctgagagac ttccaaaaca ttccgtgttt ggcttccact 1183261 ttggcaacct ttttagcaaa cgccagtttt ttcatttctt tttctacctc ttcaaggctc 1183321 aggtcatata caagagcaat ttccttcgag gcaacgaagc ggaaatattc aataaaacat 1183381 tctaaaggcg gtgtttccga cggcttcggc tcgtcgccaa gcatctcaaa taaaatttct 1183441 tcatatacat catatgagta gctgccagga actttaagcc cttcatcctc atgctgcgta 1183501 ttaaaaaacg tcagtgtcgg attaacagaa acatccatct cggcagcaat tttcatgtca 1183561 cattgaagcg ccttgaccgc gctttgagaa tgcagatctt ttttgaattc ttcaagatcg 1183621 agacttgtat tttcagcaat ctccaaaagc acgttttcat ccgtaatatt tttctttgaa 1183681 acaaataggc tctcctgcat atttctgaga aattgcatgc cggcttttcg tccttgcagt 1183741 tcggctgctt taaaagcgag agcagccata taaggcgatg aaagcggctg atcctgttcg 1183801 aaccagacat tgccgtcaca tgacatgcca gagcggctcg cgatcttttc ccatgcttct 1183861 gcgagaagat gcttttttcg ctttttattt aaagcggtaa ggcttgcgga agcgataatg 1183921 cgtaaggtga aaaaacgtcc gtatctgatt ttcagctttt tgatgacggg ctctaaggac 1183981 cagcattcag gacataaagg gtctacaaac atataaattt caagcggttt ttttggatga 1184041 ccgtggcaat gggcgaagta tagctcatgc tgatagtttg tcaagatgat cgatcctccg 1184101 cttccgtttg attcaccata tgccttgctg tcaactccag ccggccaaac aaaaactcac 1184161 gaatttcgcc ctccagccct acatggtcca ttgcgtcctt catacagctg agccacgcat 1184221 cagctctctc gtttgtaatt ggaaagggaa gatgccttgc tctgagcata ggatggccgt 1184281 gttcctcagt ataaagagga ggcccgccta aatactgagt taagaattgc ttctgtttcc 1184341 tggcggtttc tgtcaaatcg cttggaaaaa tcggcttcag caaaggatga gacgcgacac 1184401 gctcataaaa agtatcaaca agttgcgata gaagttcctc tccaatcgct tcataaggtg 1184461 cgttaaacga ttgtcccatg ttgactactc ctttaaatat ggctaatagg aatcataaat 1184521 cctattgcaa aaagtaattt tctgtatttc attgtttcat ctagatttat tttagcaaca 1184581 aggcatcatt tctacaaaca aactgccttt tatgcgtttg atgactcatt tcggctgaca 1184641 gccggggttt gtatttcata tcatatcaca taaaaatcag gaatgcgtaa gatttcactt 1184701 cgcaaaaaaa ccagagggaa agagcacctc tggttacgcg taataaactg aagttatttt 1184761 ttttacatag ttttgcgttt cttggaaagg aggaatgcct ccgtatcggt caacattccc 1184821 cggtccggcg ttgtaagccg ctaatgccat agacacattg ccgtcgtatt tatccagcat 1184881 ttgttttaaa tatttcgttc cgccctccac attttgctgc ggatcaagcg gattggaaac 1184941 gccaagtgag cttgctgttg acggcatcag ctgcatgagg cccatcgcac ctgctccgct 1185001 gaccgctttt gcattaaagc ctgattcctg tttgatgacg gcgcggatca gtttttcatc 1185061 aacgccatat ttatcagcgg cttttttaat cgcactgtca atagagaagt ctcccgaacg 1185121 gatctgattt gcttcatgtt tgtttgaagc tgaatctgca acagctgttt cagtgctttc 1185181 tgccgctttt gtgactgaac ctgaattgct gctcgtatat gagttaagcc catacgctga 1185241 aagcagtgac ggcgctgttg tattcgcgct gttcagcatg ctgagcgggc ttggcgatga 1185301 agaaggtgct gattgctgag atgtcagacc gtttgtatat tggctgagca aagaactgaa 1185361 acttgaaagc gggctttccg tattctgagt gtccgagctg ctgcgtgcat tagatatgga 1185421 ctgtaatgcc tgaagctgaa gtaatgctgc ccaattcgtt acattcacga tgtcattcca 1185481 ccttatatag actttcgttt ttcttcataa aaacgcagaa ttttattttt ggtttcgcgc 1185541 tgaggaatgc tgaattgctg aagcagcttt tcgaaggctt gtctgccctc atgccaatcc 1185601 gccgcctcaa attcaatttc atagtcctct ttatttaaat atcggctgtg gtctaaaact 1185661 attaagcctt tttctgtttc tttttccgca cggtttgttg ctaaagatcc aaagtattgt 1185721 atggcatccg tatcgatctg aagcttgtgc agctggtcct tcacagggcc ctcgggaact 1185781 gaaaatccag cgagatctga tacctctgaa agctgctggt gcgtttccag aagccccaca 1185841 tcagccggct cctttaatgt aaggacatac tttccgtttt ttctgcggat acgaagcgca 1185901 gcatgttttt gtttcagcgc gaagctgtct gtatcaaaat aatgattctt ttgatctgta 1185961 aaatcttttt ctgtcagctg gagtgccgat gctatgtttt tgaattcttg tttggtcagc 1186021 atgtttttaa attcgatttc aatctcttgg ctcatgatgc tcttcctttc cgccctgtaa 1186081 atcttatttt tactattatc tctttagatg ttaggtttat caatatcgag ctcgatatga 1186141 taaaatgaat ctgtactttg tttaaaaaag gagagcatta tgcaaaacag aatcgaaatt 1186201 ttgaatgcaa cattatcgga tgatcagctt cgccttgcct gtcagacaga aggaaacgaa 1186261 gcggaacgca agccgtcagg tcaaatgctt gttgattctg accactttgc ttttgtatac 1186321 atacttgaat tagctgattc ttttgaatat gtcattataa aggaacatgt atggccggaa 1186381 ctgaagcagg cccatgcaca aaaaataccg gttgttttag aggcaggaga ccaaacaatt 1186441 gaactggcag gcctgcatga ggagctggaa tatcttttag aaaatataaa agataatgca 1186501 aactatggag aagaaatgga agaaaaagtg aaacgcgtgt ttttatagaa actggttcgg 1186561 aattggggga tgtatgatgg atgacaaaca atgggagcgt tttttagtgc cgtaccgcca 1186621 ggctgtcgaa gagttgaaag tgaagctcaa ggggatccgc acactatatg aatacgagga 1186681 cgaccattca ccgatcgaat ttgtgaccgg acgcgtcaag cctgtggcga gcatacttga 1186741 aaaagcgaga cggaaaagca taccgctgca tgaaattgaa accatgcagg acattgctgg 1186801 ccttagaatc atgtgccaat ttgtcgatga catccaaatc gtaaaagaga tgctttttgc 1186861 cagaaaagat ttcaccgttg tggatcagag ggattatatt gcggaacata aagagagcgg 1186921 ataccgatca taccatcttg ttgtgctgta ccctttgcag acggtatccg gagaaaagca 1186981 tgttctcgta gaaatacaga tccgtacact ggcgatgaat ttttgggcga ccattgaaca 1187041 ttcattgaat tataaataca gcggaaacat tcctgaaaaa gtaaaactaa ggcttcagcg 1187101 cgcttctgaa gcggcttccc ggcttgatga agagatgtcg gagatcaggg gtgaagtaca 1187161 ggaagctcaa gctgcctttt caagaaagaa aaaaggaagc gagcaacaat aggtaaaggg 1187221 gaagaagagc atgaaatttg ccgtatcatc aaaaggagat caagtttctg atacgctgaa 1187281 aagcaaaata caggcgtatt tattggattt tgatatggaa ctggatgaaa atgaaccgga 1187341 aatcgttatt tcagtcggag gcgacggaac gcttttgtat gcttttcaca gatacagcga 1187401 ccgtttggac aaaacagcat ttgtcggcgt tcacacaggt catctgggtt tttatgccga 1187461 ctgggttcct catgaaattg aaaaacttgt tcttgccatc gcgaaaacgc cgtatcatac 1187521 agtcgaatat ccgcttctcg aagtcattgt gacctatcac gaaaacgagc gggaagaaag 1187581 atacttagct ttgaatgaat gtacgattaa aagcatcgaa ggaagccttg ttgctgatgt 1187641 ggaaatcaaa gggcagctct ttgaaacctt ccggggcgac ggcctctgcc tgtcaactcc 1187701 atcaggcagc acagcctaca ataaggcgct gggcggagcg attatccatc cgtctatcag 1187761 ggcgatccag cttgcggaaa tggcttcaat taataaccgc gtgttccgta cggtcgggtc 1187821 acctctgctt ctcccatccc atcatgattg catgattaag ccgagaaacg aagttgactt 1187881 tcaagtgacg attgaccatt taacccttct ccataaggat gtaaagtcga tccgctgcca 1187941 agttgcatcc gaaaaagtgc ggtttgcgag attccgtccg tttccatttt ggaaaagagt 1188001 ccaggattcg tttattggaa aaggtgaata gaaagaggac atatcgtgga gcattttttt 1188061 atcagaaaga acattacttc cgctgaggac gggatgactg taaaagaata tgccggtgaa 1188121 ctgggaattt cgaaacgtct gctgaccgat attaagtttg gcgggggaga cctgcagatt 1188181 aacggtgagc atgtgacggt caaatacgtt ttgaaagagg gagatcttct tatcgtgaag 1188241 tttcctgagg agcaggtgag cgagacgctg ttggcagagc ctgttccgct cgatatcctt 1188301 tatgaggatg aacatgtgct tgtgataaac aagcagccgt atgtgtcatc aatcccttcg 1188361 agagagcacc cctccggcag cattgccaat ggaattattg atcattatca aacaaccgga 1188421 gtgagggcga cagttcatct tgtcacccgg ttagaccggg atacatcagg tatcatgctt 1188481 gttgccaagc atcgatttgc ccactccatt ttatcgtctg cgcaaaaaaa cggccttgtg 1188541 aaacgccggt atgcggcagt ggttcacggg cggatggcac agatggaggg aacagtcgat 1188601 gctccgattg gcagacatcc tgacagtatt attgaacgga cggtaacgcc agacggccag 1188661 aaggctgtta ctcattttta cgtcacatgt gcaaatgatg acatgacctc ggtggcattg 1188721 cagcttgaga ctggacgaac ccatcaaatt cgtgttcata tgagctatct cgggcacccg 1188781 ttgtgcggcg atacactgta cggcggaacg agacaggaaa ttggccggca ggctctgcac 1188841 agcgagcatc tttcgtttat ccatccgctg acacaggaga acatgaggtt tcatgctcca 1188901 ctgcctcagg acatgagcaa actgataaaa ggagagaatc attgattctc tcctttttta 1188961 tatggggcga aatcttgatt cgtcgtaagg cagggagctt ggaacagaga cggtttctat 1189021 ttctggaaag cgaaagcctg tcagttgatt tccgaacacg cagcctgtat caatgttgat 1189081 ggtgcgattg accttccgag gctctttcac aggtgtatga ccgtatacca cccaagcctt 1189141 tccgttatag gctgccgccc aatcacgcct gatgggtctg ccgtccggat atgtttcacc 1189201 cgtcacgtca ccgtaaagca caaagtcctt cactctgcgg gtatatttgc cgatatcgtc 1189261 agctcttatg ccagcatggg cgacaactaa ttctccatta tgtaagatgt cgtaaagcgg 1189321 cgctgtttcg tacagcttca taaactgttc gctgactgat tttttctcat ctttggaaag 1189381 ttcctcaagc tctgccgctg ttgtttcgag accatgcatc acttttaccg gatttccttt 1189441 taagtaacga tataatttat tgcaatggtt tcccgggaca taacgcacag cgcctttttc 1189501 gtaagcgccg gctacaaatc ggatgacctc tatcgatttg ggccctctgt cagttaaatc 1189561 tccggcaaaa acaagcaccc tgccttcttc atggacaggt actccatttt tgattgtata 1189621 gccaagcttt tggattaatg cagtcatttc gtcatagcag ccatgaatat cgctgatgat 1189681 atcgtaagcc atgcggtctc ctccttaccg attgttttat ttattatgaa gcaaagtgtt 1189741 gtgagtcatc acaagctttt atgtgcaaat tatagaagaa gaatcatttt ctaaacagga 1189801 ttaagacctt atcactttat ttttcatcat cacccttgtt aaaatcgcgt tatgtttttt 1189861 aaaaatgagg ttttgttctc tgagtgagaa ctagcataac cctgacttaa aaaggaggtt 1189921 ctgattatgg cgcatacatc tgtcgcatct ttagttgttg tacttatcgt tgcatttttg 1189981 acacccatcc ttttgcatcg gtttaaactc agcatcccgg ttgttgttgc tgaaatcatt 1190041 atggggctga taattgggaa aagcggcctt aatttagttg tggagggtga cacctggctc 1190101 cagacactct ctatgctcgg atttatcttt ttaatgtttt taagcgggct tgaaattgat 1190161 ttttcgtcgt ttgagaaagg aaagaaaaag cagttcctgc cgaatggcaa ggaagcgccg 1190221 aatacgtttg ctgcggcatc tgttattttc gtcggtattt ttattttatc attgctcttg 1190281 tcctatgggt tcgtcttggc cggatttatc caaaatgcat ttttgatgac cctgattatt 1190341 tcaacgattt cattaggcgt tgtcgttcca acattaaaag aagaacggat catgaattcg 1190401 aatatcgggc agattatttt gcttgttgct gttattgctg atttggccac gatgattctt 1190461 cttgctgttt tttcttcttt atacggagag gacagcggaa acatgtggct cctgatgatt 1190521 ctgtttgcgg ccggagtggt gctttacttt ttcggccggg tcttcaaaca tcgctctttt 1190581 gttcaatcca tgtcaaaagg gacgatccag atcgggacgc gtgccatttt tacgttaatc 1190641 attgtactcg ttgccctgtc tgaatcactt ggggcggaaa atattctcgg cgctttctta 1190701 gcgggggttc ttgtttccct gctttcgcca aacaaagaac ttgttcagca gctggactca 1190761 ttcggttatg ggttcttaat accgattttc ttcgtgatgg tcggtgtgaa gcttgatatt 1190821 tggactcttt tccaggataa aacaatttta atcatgattc cgctcctgct gcttgcgctg 1190881 ttagtcagca aaatcattcc tgtcatgtac ttaaagaagt ggtatgataa ccgaaccatt 1190941 ttcgcgtctg gtttcctgct gacatcaacg ctttcgctcg tgattgctgc tgcaacaatc 1191001 ggccagcagc ttcacgtgat cagtacaaat atgtcaggag cgctaatttt agtagccgtc 1191061 attgcaagta tttttacgcc gatctgtttt aaaaaattat acaaacggga agagcagccg 1191121 gaggagaaaa agacgattac gttcattggc gccaatcaaa tgactttgcc tgtcacactc 1191181 gaattgccag aggaagagta tgacgtgcgt gttgtacacg tctaccaaga gaatgcggag 1191241 gaaaagctgt cagaatcagt gtttgctgtt gaaacaattt ctgactatga acacgagacg 1191301 cttgaatcac tcggcatttt tgaaacggat atcctcgttg tggcgacagg aaatgaagat 1191361 atgaatgcag acattgcatt acttgcaaaa gataaaggca cagaaagagt cattgcaagc 1191421 gtaggatcac cggagcatga agcagctctg aaggagcagg gaatcagcat cttttctatt 1191481 ctgctgtcga caaaaacgct gcttcgcgca ctgattgaag cgcctggcgt catgaagctg 1191541 ctcacgaacc aagagtcttc gctgtatcaa attaatatgg agaacagtaa atatgatggt 1191601 gtcattttac gggaattccc tttaacaggt gacgtcatct ttgtcaggat cttcagaggt 1191661 gtggacagca tcgttcctca tggggatacg aggctgaaac ttggagaccg tttaattgtc 1191721 accggatctc gggggtacgt aacggatctt aagaaaacat tggaaggata aatcttgacc 1191781 aaataaggat tcgtgttaat atagaggtgc agaacaattc aatatgtatt cgtttaacca 1191841 ctaggggtgt ccttcataag ggctgagata aaagtgtgac ttttagaccc tcataacttg 1191901 aacaggttca gacctgcgta gggaagtgga gcggtatttg tgttatttta ctatgccaat 1191961 tccaaaccac ttttccttgc gggaaagtgg tttttttatt ttcagagggg gaatgatttg 1192021 tgaagttttc agaagaatgc cgcagtgcag ccgcagaatg gtgggagggg agctttgtcc 1192081 atccgttcgt tcaaggaatc ggtgacggaa cgcttccgat tgaccgtttt aaatactacg 1192141 tacttcagga ttcctattat ttaacgcatt ttgcaaaggt gcagtcattt ggtgccgctt 1192201 atgcgaagga tctttataca acggggcgga tggcaagcca tgcccaaggt acatatgagg 1192261 cggaaatggc gcttcatcgc gagtttgccg agctgttgga aatcagcgag gaagagcgta 1192321 aggcgtttaa gccgtctcct acggcgtact cttatacatc ccatatgtac cgttcggttt 1192381 tgagcgggaa tttcgcagaa atcttagcgg ccctgctgcc atgctattgg ctctattacg 1192441 aggttggtga gaaattgctg cattgtgatc cggggcatcc aatttatcag aagtggattg 1192501 gcacatatgg cggtgattgg tttagacaac aggtcgagga gcaaatcaac cgctttgatg 1192561 agctggcgga aaacagcacg gaggaagtgc gtgccaagat gaaagagaat tttgtcatct 1192621 ccagctacta tgaatatcaa ttttggggaa tggcctatcg aaaagaaggc tggtctgaca 1192681 gcgccataaa agaggtggag gaatgtggag cttcacgcca taacggatga cagcaagccg 1192741 gtagaagagc tagcgagaat catcattacg attcagaatg aagttgattt tattcacatt 1192801 cgggaacgct caaaatcggc ggcggatatt ttgaaactgc tcgatcttat ttttgaaggc 1192861 ggtatagata aacgaaaatt ggtgatgaac gggcgcgtgg atattgcact tttctctact 1192921 attcaccgcg tgcagctgcc aagcggcagc ttttcaccga agcagatcag agccagattt 1192981 ccacaccttc atatcgggag gtcggtgcat tcactggagg aagcggttca agcagaaaag 1193041 gaagacgcgg actacgtgct gttcggccat gtgtttgaaa cggattgcaa aaagggtctt 1193101 gaaggcagag gagtatcttt gctgtcagat atcaaacagc ggatttccat cccggttata 1193161 gccatcgggg ggatgacgcc ggacaggtta agagacgtaa aacaagcagg ggcagacggc 1193221 attgctgtta tgtcaggaat tttctcttcc gctgaacctt tggaagcagc cagacgatat 1193281 tcccgcaagc taaaggagat gcgctatgaa aaggcattat gaagcagtgg tgattggagg 1193341 cggaattatc ggttccgcaa ttgcttatta tttggcaaag gaaaacaaaa acaccgcatt 1193401 gtttgaaagc ggaacaatgg gcggcagaac gacaagtgcc gctgccggaa tgctgggcgc 1193461 ccatgccgaa tgcgaggaac gtgacgcgtt ttttgatttc gctatgcaca gtcagcgtct 1193521 gtacaaaggt cttggagaag agctttatgc attatccggt gtggatatca ggcagcataa 1193581 cggcggtatg tttaagcttg cattttctga agaagatgtg ctgcagctga gacagatgga 1193641 cgatttggac tctgtcagct ggtattcaaa agaagaggtg ttagaaaaag agccgtatgc 1193701 gtctggtgac atctttggtg catcttttat tcaggatgat gtgcatgtgg agccttattt 1193761 tgtttgcaag gcatatgtga aagcagcaaa aatgcttggg gcggagattt ttgagcatac 1193821 gcccgtcctg catgtcgaac gtgacggtga agccctgttc atcaagaccc ctagcggaga 1193881 cgtatgggct aatcatgttg tcgttgccag cggggtgtgg agcggaatgt tttttaaaca 1193941 gcttggactg aacaatgctt ttctccctgt aaaaggggag tgcctgtccg tttggaatga 1194001 tgatatcccg ctgacaaaaa cgctttacca tgatcactgc tatatcgtac cgagaaaaag 1194061 cggaagactg gttgtcggcg cgacaatgaa gccgggggac tggagtgaaa caccggatct 1194121 tggcggattg gaatctgtta tgaaaaaagc aaaaacgatg ctgccggcta tacagaatat 1194181 gaaggtggat cgtttttggg cgggactccg tccgggaaca aaggatggaa aaccgtacat 1194241 cggcagacat cctgaggaca gccgtatttt atttgcggct ggccatttca gaaacgggat 1194301 cctgcttgct cccgcaacgg gcgctttgat cagtgatctc atcatgaata aagaggtcaa 1194361 ccaagactgg ctgcacgcat tccgaattga tcgcaaggag gcggttcaga tatgatgcta 1194421 cagctgaacg gtaaagacgt gaagtggaaa aaagacacag gtacaattca agacctgctg 1194481 gcgtcgtatc agcttgaaaa taaaatcgtt atcgtggaaa gaaataaaga aataatcggg 1194541 aaagaacgct atcacgaggt tgagctttgt gatcgtgatg tcattgaaat tgtccatttt 1194601 gtaggaggcg gatgagcatg ttaacaattg gcggaaaatc atttcaatca agattgctgc 1194661 tgggcacggg gaaataccca tcgtttgaca ttcaaaagga agcagtagct gtttctgagt 1194721 ctgatatttt aacatttgct gtaaggagaa tgaacatttt tgaagcatct cagccgaatt 1194781 ttctggaaca gcttgattta tccaaatata cgcttttgcc gaatacagcg ggcgccagta 1194841 ctgctgaaga agcggttcgg attgcaaggc tggcgaaagc ttcaggcctt tgtgacatga 1194901 ttaaagttga agtcatcgga tgcagccgtt ccttgctgcc tgaccctgtt gagacattaa 1194961 aagcgtctga acagcttctt gaagaaggct ttattgtgct cccgtacacg tcggatgacg 1195021 ttgtgctggc gagaaagctg gaagagctcg gcgttcatgc catcatgccg ggtgcatctc 1195081 cgattggatc aggacaagga atcttaaatc ctttgaatct gtcgtttatt attgaacagg 1195141 cgaaagtacc ggtcatcgtg gatgcgggaa tcggctcgcc taaagatgcg gcatacgcaa 1195201 tggagcttgg agcggatggc gtactgctca atacggctgt atctggcgct gacgatcccg 1195261 tgaaaatggc tcgtgccatg aagctcgcag tggaagcagg gcgcctttct tatgaggcgg 1195321 gccgaatccc gcttaagcaa tacggaacgg caagcagtcc gggagaaggt cttcctgtat 1195381 gacaggcagg tattcaaggc aggagctgtt tgctccgatc ggcccatccg gccagaaaaa 1195441 attgaaagaa gcgcgcgccg tgattatcgg cgccggcgcg ctcggaacag ccagtgcaga 1195501 aatgctggtg agagcgggag tcggctctgt gaaaattgcc gacagagatt atgttgaatg 1195561 gagcaacctc cagcgccagc agctttatac agaagatgat gtcaaaaaag aaatgccgaa 1195621 agcagccgct gcggagcgcc gtctccgttc gattaacagc gatgttgatg tgaccggcct 1195681 tgtcatggat gtgacagcag aaaatatctt cgagctgatt agggatgcat cgattattgt 1195741 ggatgcggct gataattttg aaacccgcct gatcgtaaat gatgctgcgg taaaggaagg 1195801 gattcctttt ctttacggtg cctgtgtagg gagctacggt cttaccttta ccgtggtgcc 1195861 gggttctact ccttgcctgc attgcttgct cgatgcactt ccgattggcg gagcaacatg 1195921 tgacacagct ggcatcatca gtccggctgt tttgcaggta gcagtctttc aggtaacaga 1195981 tgcactgaaa ctgctgacgg gagaggagtg cgagccggtg ctgcgctcct ttgatttgtg 1196041 gaaaaacgag cggtcagaag tgagagcggc cagtctcaaa catgacgcat gcccaagctg 1196101 cggcacaaag gattttccgt ttttgtctta tgaaaatcaa acaaaagcgg ctgtattgtg 1196161 cggcaggaac acggtgcaga tcagatcatc tattacgaaa gaagcggatc ttgaagcgct 1196221 tgccggtcag ctgaggcagg ccgggcttga agtagctgcg aacccgtatt taatttcctg 1196281 ccgctcggat gatatgaaaa tggtgctgtt ccgggacggc agagctttga tccatggaac 1196341 aaatgatatt gcccgggcaa aatccattta tcataaatgg attgggtaat aaaaggagtg 1196401 tagtgtaatg agtatatata aagcattgac aatcgccgga tcagattcag gcggcggcgc 1196461 agggatacag gctgatatta aaacctttca agagcttgat gtattcggaa tgtctgcgat 1196521 tacggcggta accgctcaaa atacgcttgg cgttcacggg gtgcatccgc tgactgtaga 1196581 gacgttgaga cagcaaattg acgctgttgc tgaggatttg agaccggatg cagttaagac 1196641 gggaatgctc tggaatgccg acatgattga agaagtggca agaaaaattg acgagtacgg 1196701 attcaatcgt gtaattgttg atccggttat gatcgcaaag ggcggggcat ccttgctgcg 1196761 tgatgagtca gttgccacct taaaggagtt gctcattcca agaagctacg cgattacgcc 1196821 gaatgtcccg gaagcagaaa cgctgacagg aatgacaatc agctcgctgg atgaccggaa 1196881 aaaagcagcg gagcagctcg tcaagatggg tgcgcagcat gtcattatca aaggcgggca 1196941 ccagcctgag gacaatcaca ttactgacct tctttttgat ggcagcatgt ttatgcaaat 1197001 cacccatcct tatatcaata cgaagcatac gcatggcaca ggctgcacct ttgctgcggc 1197061 tttaacggcc caaacggcta aaggagacag catccatcag gcatttgagg ttgcggccaa 1197121 ctttgtccgt gaagcggtgg aaaatacgct cggcatcgga tcgggacacg ggccgacaaa 1197181 ccatttcgct tttaaacgaa acagcttaaa tacaagccga tgagatcacc agctgatggt 1197241 gatctctttt gcgtttgcta cggtatgcgc ttttcatctg gacaaggtta tgatatgata 1197301 ggaattaaga tcaggtacta atactatgtc tttattaaat ataggaggct ttatacatat 1197361 gaatttttca cttgaaggcc gtaacattgt tgtgatgggg gtagccaaca aacgcagcat 1197421 cgcctggggc attgcgcgtt ctttacatga agcgggtgca cgtttgattt tcacatacgc 1197481 tggtgaacgc ctggagaaat ccgttcacga gcttgccgga acattagacc gcaacgattc 1197541 catcatcctc ccttgcgatg ttacaaacga cgcagaaatc gaaacttgct tcgcaagcat 1197601 taaggagcag gtcggtgtaa tccacggtat cgcgcattgt atcgcgtttg ccaacaaaga 1197661 agagcttgtc ggcgagtact taaacacaaa tcgtgacggc ttccttttgg ctcataacat 1197721 cagctcatat tctctgactg ctgttgtcaa agcggcacgt ccgatgatga ctgaaggcgg 1197781 aagcattgtc actttgacgt accttggcgg agagcttgtg atgccaaact acaacgtcat 1197841 gggtgtagca aaagcttctc ttgatgcaag tgtgaaatat ttagctgctg acttaggaaa 1197901 agaaaatatc cgcgtcaaca gcatttctgc cggcccgatc agaacattat ctgctaaagg 1197961 catcagcgat ttcaactcta tcttaaaaga catcgaagag cgtgcaccgc ttcgccgcac 1198021 gacaacacct gaagaagtgg gcgatacagc tgcgttcttg ttcagcgata tgtcccgcgg 1198081 gattacaggt gaaaatcttc acgttgattc tggtttccat atcactgccc gctaagcagg 1198141 atctatatca agcaatcccg aatagggatt gcttttttat ttcttctgat tttcagcttt 1198201 ctgtcatata gatagaatat gacacaatcg gagggatgaa gatgtctaat aagaaaagaa 1198261 acgcggataa aaaaccgctc atgtatattg ttcagccgga ttatgcagaa actacaaggt 1198321 catccatgca ggagattgtc atcaaaagaa aggccgacaa acccgctccg ccaaaagctg 1198381 aggaaaagcc ggcttaccat gagaagcagc aggaggaagc cgtggcacag gatgtcctgc 1198441 aagaagacca aaagcctgca gccgaaccag tgagtcagca aacacaagag gcgagagagc 1198501 cagagaacat aaaaagccaa gaggaacaga aggcagagcc gcaggccgta gaagaaaccg 1198561 ttgaacacga gcccccgaaa gcagaaaaaa aggaagagcc tgcacttgag gcccggaagc 1198621 ctgagaaaga accggaagct gtccatagtg ctgataaagc ggaggaaaaa gcaccgccgg 1198681 cacgaaaagt gaaaaaaccg atgagcaaga tgacgatcca cgaaaaaatt gattttttaa 1198741 caaagctgcc tcataacatg ccgagagcgc tttgtttgat tgaagccaat ggaagaacgt 1198801 acaggggcgt gattgtcgga agaagaaatg attccgtcct gcttcgaaca accggaaacg 1198861 gagccccaac cgaactggca atcgatgata ttacctcttt gcacccgctc ggtttttaac 1198921 gaaaaagaaa aaagctgccc ggctgatgtt gccggacagc tttttttaca tagagaaaag 1198981 cctgcaggcc tgcaagcttt tccagcttat gattaatgat gatgtgtacg attgattaat 1199041 cgaggattta agcagttgat tgcgcagaag cagtctaagt caacttcaat acagtagttc 1199101 gttttttcga gtcggaacac ttcacacacc gtatctttat cggtgaagtc caaaatgtgt 1199161 ttgtgttcgt caaatgcgat taataatgac agtgttgcac agcttccatg cactctttcg 1199221 accctgaaaa atactgtatt aaagcaaggg ccgttatcga gttcgccgac atttccgaag 1199281 gcgactaatg gcgttgattt tgatgtaaat attgcaaaag gcactgtgtc gcctaacgaa 1199341 tggcttacag ataaaagctt agagtggcag ccggtcgggc agtcttcttc aacagcgttt 1199401 tgcagatctt caatattttc tacagcttca cgcacgcagc ttgatgtttt ctggctcata 1199461 ttatccctcc tgccttataa atttgagact ggcgaaatga tggagagtca gctgcctcac 1199521 gctggaagca gctgaatgat ttgcacctgt aatagagttt ggaaggggat tcctctttac 1199581 aagtgtttat ccattgtgat gatgcttttt atctttgtga ggcgatgttc tgtcaactag 1199641 ctctggtgac aggcactgaa tcgcgcagaa gcatccgaga tccacttcaa tgcagaaatc 1199701 tgttttttct agcccgaaga aatccgggtc gcaagggtgg caaacactta aggtatcgcc 1199761 tttgacatcg accgggcgta aaatagacag tgttgcacag caatcgcata atttttcgac 1199821 gcggaagaaa atggattcaa agcattgcat atcatccaca aatcccccta cgtttccgaa 1199881 tgtggagaac aatccgcctt ttttatcaaa aacgagaaac ggaattgtgt cttttccagc 1199941 aatcgtaggg tttaaaaggt tggtatagca gccagtcgga cactgttctt caactgcctc 1200001 ctgctctgct aaaatctttt ccactgcatc gcatacacag ttctcatgcc ggccatgggt 1200061 ttttccgcag ctcattgatt tcagctcctt ctttataggg tatttgactt tagtccttaa 1200121 caacatatgt acccgtgccc cacttggtgt gggtgaacgt ctatatattc atcatatgct 1200181 tggaaaataa gaaaaagcag agcgttttta gctctgcttt taggtcctag aggacaagag 1200241 tgataactag gatggctacg agtgtatttg ttgctgtaga aataagggtt gcgatatcgg 1200301 catctactgt tgtgacgttt acgccgcggg aacattcgat gagaagtttt tggcggttta 1200361 cttgtttgtt agctgtaagc tgtaacaaat cttgtgcgac taattcggca attacgccgt 1200421 ctgcaattga tgtcagagtt gccgttacga cagcggcatt aagtgctgtt acaactgatg 1200481 ttacggcttg aacgtctgta gatgtaacat tgatgtcaca agaatctcta ataataatcg 1200541 tttcatctga aacttgtttg ttgagatttg cttgagctag atcttggtcg atgaaggcgt 1200601 tgtcgttgcc aaaaaaacca ttgccattac agcaaacgtc gcaatgacat tttctttcgt 1200661 gtttttcttt atctttctct ttgtcatcta acggatggtc acagtcagga tcaagtgcaa 1200721 cccaagaata tggtctgctt tccatatcta ttcctccttt tcttttactg ttattaaatg 1200781 agcgagcctc ttattttgac tgagtcatat atcctgatga agaaccctat tttttatgat 1200841 tggctaattg ttatcgtttt tccgtctttg tctgatctgt tcaatgagct gctctctgcg 1200901 gcttaacggt tttgtgttct tttgctcttg tgcggctgct tcttcttttt tcttcttttg 1200961 gttttctatt agcgcttgtg atttagcttg taagtctttt acaagattta agagcatttc 1201021 tttttcttcg tctgatactt ttttcatttt gtcttttgtg accccatgtt tagaaaatat 1201081 attttggacc agcattttcg tcattggatc aacttctgga agctttgcaa gctcttcttt 1201141 gaatttatcg ttatctgaca tttgttttca cctcgtcttt taagtttgtg aaaagaaagg 1201201 gttaaaggac gtcaagttca ctaagaatgc tgtttaacac ctgaagcaag atttgtacaa 1201261 aggttattat ctcgtcggca gacaaagtaa ttttgatgtt gcggctgttg ataattttaa 1201321 tgatggttct ttttttgatt tgggagctat cgagaataag aatttcactt gccactgcgt 1201381 cagccaaatc ctcgtcggcg atgacgagct gagtcgccac gataatcatg gttgtcacaa 1201441 aggcttgtat agaaagggca gctgttatat gtgacgtgtc aattgtgata ttttcgcaat 1201501 caatcacttc gatctgctgt tcgaattcgc ttgataattg ctcaaatatt gcagggtgca 1201561 gggattcgac tttttcttca aatgacataa ccttcactcc tttcttatcc atactctata 1201621 taatgcaaat ggggtgcaga gcggaataat aaaaataacc aattttctgc cggacaagat 1201681 acaattcatg aagaataggg ttttggcata tatgtgaagg gatcatgatt ggcaaaggag 1201741 tgaacgagtg gttataaatg ggctgacaat tgttcttcta tcgcttgcgg tctttcggct 1201801 cgcccgcctg ctggtgtttg acacgattat ggcgccgctt cgcagtctgt ttcatgaaga 1201861 gaaggaagaa aaggatgcgg acgggaacat tgaaacctat atcgtgatta agggaaccgg 1201921 tgtcagggcg tttattggtg aattgctgag ctgctattgg tgcacaggcg tgtggtgtgc 1201981 cggctttttg attttatgcc aggcggtgat cccgcaagcg gcgcagtggc tgattttact 1202041 tttggcgatc gccggccttg ccggcattat agaaacgctc gtatcaaaat ggctgcaaga 1202101 ataaggcgtt accaccagca actttctgtc agaatacgca taaagtagca tatatgacat 1202161 aaggaaagga aggggacaaa aatgaatcag catcataaac cttcccaaaa atctccatat 1202221 acagattcat cgtatcaatc aaaaaagata aaaaagaaag gctgcgggtg cggaaataaa 1202281 aagaaaaagc ctcaatagcc tggcaaagaa accggagaac tccggttttt tgttttttta 1202341 acgaggcggt ctcgctcagc atatatcata agcgggggga taaaagtgaa tgagtttgaa 1202401 aaatggatag aaggaagata tgaaccacat gaacaaaagc aaaaagagca tgaagacacg 1202461 atgggcagta tcagaaaaga cttggatgca tttgataaag ccggtctgga atttgaagat 1202521 gagattgaag agctggctga aaaaacggag gccttactta aaaaacatca agctcaatat 1202581 gatcaatcgt aaatccgcaa acgccctatg cgaatatcca agccgatccc agcagctcac 1202641 atagtgtata gagagtaaag gaggtgctta tctatgggct ttggatacgg attcggcggc 1202701 ggctacggcg gcggctgtta tggcggttat gctggcggtt acggcggcgg ctatggttca 1202761 acatttgttt tgttggtcgt attattcatt ctcctcatca tcgtaggtgc atctttcttt 1202821 taagatgtat tgaggaagta cgggttataa cccgtacttc cttgccttgt gtttattttt 1202881 aaaaatgttg gaaaagcaca ttgtattatg tgcattcata caataccgta ttactccgcc 1202941 aaaaggaggc gcattatgga taatcaattt tttaagaaca tcgaaaagaa aacaggtgtg 1203001 aagatgcagg atgtaatgaa tcttgccgga tcactccaaa acgctaattt taaagatgaa 1203061 aatacagtgc gcagtgtgat taaccgcgta gcgcagatgg caaacagacg cgtgccaaaa 1203121 gaattagaag ataaaattgt ggaatctatt acaagcggaa aagaaaagct tgattttggc 1203181 acgatttcta aaatgatgga taataaataa gtggatggcc tggctgactc actgcagcgg 1203241 gccttttttt acagtaaaaa cccggcagta atctgccggg ctgttaatga tgcaagggct 1203301 gtcttgcttt ctgtagcagg ggatacaaaa atcttgagcg gttggctgtt ttgccgcgcc 1203361 tgttagcagg gcaagacaaa tataaatgct gtttcgcccg ggtcatggct acatataaaa 1203421 ggcgtctttc ctcctcaaga gcggcctcgt ctccttttct tgccgtttct aatgagaaat 1203481 cgtgcggaat cgagccatct acagtgccta acacgtagac tgttttgaat tcaaggcctt 1203541 ttgaccggtg aatggtcatc agctgaacgc catgttcatc cgttctgttt ttctcagcgg 1203601 ccctcatatg gtctacgtgg gcaagaaagt caggaatcgt tttgaacttc ttggcgacaa 1203661 ccttgatgtc gcgcaggtca tcagagcctt tttccagctt gttgccctca ttgccccgct 1203721 tttttaaata ctcggagaag cccatttttc cttctgcaaa ggtgatggct tctacgggtt 1203781 tcattgtgcg gaggcttgca aaaaacggta cgattttctt gattttgtcc agctggaatg 1203841 gcttcagatc aggcaatttg gccagcgctt tgatcatggt acagtcctct gtaatcgaga 1203901 gcgccttcag cgtattcaaa gcggactgtt ttaaaaacaa ggcgggaagc aagtgtttaa 1203961 tcgcctcggt gtcatcctca ttttggctgg cgtacaagta ggcgagaatc tggcggacga 1204021 tccgtctgct gtaaaacgat tggacgccgc ggtcagctgt atacggaatt gacgattgat 1204081 gaagcctttc atatatagca cggcctccgc tgtttgtgcg gtaaagaacc gcaaagtctt 1204141 ctggactggc tccattttga attttttctt tgatatcgga aacgaccatt gtggcttctt 1204201 cctcttcatc ataaggataa aacagcacag ggacctgaat gtcatcgcgg gccgcttcaa 1204261 gcgttttggc atatctgttt ttgttctttt tcacaacgat atcagcacta gagacgatcg 1204321 ggtgcgtaga cctgtagttc gcagttaaat agatcgtctt cgctcccgga taatcctttt 1204381 gaaaatcaag aatgaaagac ggattgcttc cgcgaaacgc gtagatggac tggtcatcgt 1204441 ctccgacaca gcacaggttt tgctccgggc tggcgagcat ttgcatgatt ttgtattgaa 1204501 ccggattaat gtcctgaaac tcatcaatta agatatacgt aaaccgagat tgatattgtt 1204561 ccagaaggtc aggccgctcg ataaacaatt catagcaggc tgaagccatg tcatcaaaat 1204621 caaattggct gtgttctttt ttctggcgtt cataatgttc atataaacga taaacttgtt 1204681 tttcccactc atcttttaga gggatgcgtt catttgggac ataagtgttt ttccaaaaac 1204741 cgatctgctg cagggcttgg tcaactgggg attctttctc atcgatgcct tcttcataga 1204801 gtgctttttt gatatattgt tcccgctgcc actccatttt cagcagatgc tcaccgttcc 1204861 atttagcaga attagagtga tacaagatct tataaaacag actgtggaat gttcctgtca 1204921 caattcttct gacttttgcc ggctgtaatc cgtactggtt cgccatacgc tctttcattt 1204981 cagcgacagc ttttgttgta aaggtgacaa gcagcatatt ttcaggcggt atgcctaagt 1205041 gttcgatcat gtgggcggca cgggctgtca gtacccgtgt ttttccgctc cccgcacctg 1205101 caagcacgag gagcgggccc tctgtttccg tgacagcttt cagctgatcc gtgtttaaac 1205161 cgacagacgg aaaaaggctc gtatcgggtt ctattgtttt tggcacaaat ggtgttcctg 1205221 gtttaatgct tctaggacgg tgccattctg taacagctgg ggacgggtca gcggcgatcg 1205281 cttttccctt gggtaaacga atgacaccag attcctgatc atcttctttt ttcccctctt 1205341 tagagggctt cggttcgcac gcctcctcac atgccggaaa atcgcctggc tggcgatgga 1205401 taaactctgg cggatcggcg atgttaagcc gtaacaaaac gggctttccg caatgagaac 1205461 aaaataaatg tccttttatt ccctcttcaa agaggaattg ataatgttct ctcgaatatg 1205521 tatgtaaatg tatgattcta tcattcagtc gggcgcattt caaaaagggg tcctcccaat 1205581 caaaaggtgt tcattacaga caatgactat catatcaaaa gaaatgtgtt tcaaaaagta 1205641 agtttaaggg aaaagagaca gcagaggggt gggtattgta tgatatatgc aggtcaaatt 1205701 cagaaccagc aatacgctca atatgctaat agaacgattg gacataagca ggattatgcc 1205761 ggaaccgaaa aaatcagcta tgtcccgttt cagcgggtat acaaagaact ggaaaagcag 1205821 caggagaatc aaacggcagc tgaaagaaaa gtaaacgaga tgaaacgtaa gcgctctctt 1205881 tataagagat tgcgagaaaa aggaatgggg acatatatta atcgatatgt ataaaaaacc 1205941 gttcatacca gagaacggtt tttttatatg cagtaaaaat ccggatctca aaagatccgg 1206001 atgcgttcag tccttcatca tttgtaagtg cggaatgccg gcatcgagga attctttttc 1206061 agaaagcacg cgatacccgt gtttcttgta aaacggcaca gcctgtgttt gcgcgtttaa 1206121 aatgaaaccg gaagcgcctc cgtctgccgc ggctttttcg agcgctttca taatgatgcc 1206181 gccgacaccg gctgagcggt ggcttttcag tacgcaaatc cgctctaact tgccgtagcc 1206241 gtccttcatg cgccatcttc cggcaccgac aggcttttca ccgtcataca cgacgatatg 1206301 ctctgactca ttttcaagtt cgtcaatttc ttcttcagca ggcacgtttt gttctttgac 1206361 aaagacttct tctcttacat agaatgcatc tttcagttgt tcttcatttt ttgcgataac 1206421 tgctttcaaa cattattctc ctctgcctag caagaaggtt tcatatactg tccacgatcc 1206481 gttttccaac tggtagagca agtggaaacg gtcaacgatt tcttcatgcg acacttcctg 1206541 catttttaat tgtcccagca catctgaatg ctcatcgtcg gaaagatttt ggccgaccgt 1206601 cacatgcgga acgaaattat attcctgttc tcctgccaac acaccggtgt atagcttttc 1206661 attgagtgtt tttaactctt ccgtcggttc tgctttgatg taaatgacat tattgacagg 1206721 cgcaaatgag ctgtattttg tcattttgag aacgagtggg tgggactctt ttgcgatgtt 1206781 tcttaaatgt gatacgagct gatccgcttt ctcctccgcg cattcaaagg atgctctcag 1206841 cgtcaaatga ggcgggatta gagagtagct tgggtcatag cgctttctgt aagagtttgc 1206901 aaggtcttgg agcttttttg atggaaataa aacgattccg tatttcatat tatgtccctc 1206961 ctggaaataa agtatgatag agtgttaaag catttttttc agcgccgggg tgatgagcgg 1207021 ctgccagtat gtccatttgt ggtctccgtc aaatggctcg aaatcataat cggaaagctt 1207081 tttctccagc agctgtttca gctcccggtt cggttctgta aagtccagaa tgttcccgtc 1207141 tgtcgtgtgg acgtcagttt cttttgttcc gatttggtga taaatagaga ggtgtttgat 1207201 atcgtctgac tgttttacgg cttctagtac gtgtttgtca acatagggag actgcatgat 1207261 gatgttgcca aacatattcg gataatcaag cgctgtcata agtgacacgg ttgctccgag 1207321 cgaatcaccg atcagcgttc ggccgtaacc gatctgatag gttggatact catcatctgc 1207381 aaaaggaacg agctcatggg cgatgaaccg tttataagcc gaaaattttg aaccctccgg 1207441 atgataagtg tttctgcgct cttttacatc cttataggga acaccgataa taatgctccg 1207501 gtctatttcg cgtttcgaca gcaattcctc aacctgtctg ccgattctcc ccagcctgaa 1207561 ataatcgtgg ccgtcctgcg cgataatgac atggtattta taaagcgggg agtagttgga 1207621 cggcagataa acaagcaagg tcatttcctc gttaagctct tttgaaaaga atttcttttc 1207681 ttgcactgtg ccgtttttcg gtgccataaa aacattcctc caggacatca ctatactttc 1207741 ttgcattttc aattattgta ccatgaatta ttagaaattt ctctctttaa acggttcggc 1207801 acacgaagaa aaaagtgttg aaataaactg tgaattgcgc taatataaaa caatcagaaa 1207861 attgaaatcg atatttctta tcgtgagagg tggagggact ggcccttaga aacctcagca 1207921 accggcttgt tttgcatttg caaagcgcca aggtgctaaa tccagcaagc gttttttatg 1207981 cttggaagat aagaagaagc gttaaacccc ttcttcttat gaagaagggg tttttatttt 1208041 gaaaagggaa ggtgtcagct atatgtcaca gcacgttgaa acgaaattag ctcaaattgg 1208101 gaaccgtagc gatgaagtca cgggaacagt gagtgctcct atctatttat caacagcata 1208161 ccgccacaga gggatcggag aatctaccgg atttgattat gtccgcacaa aaaatccgac 1208221 acgccagctt gttgaggacg cgatcgctaa cttagaaaac ggcgcgagag ggcttgcctt 1208281 tagttcggga atggctgcta tccaaacgat tatggcgctg tttaaaagcg gagatgaact 1208341 gatcgtttca tcggacctat atggcggcac gtaccgttta tttgaaaatg aatggaaaaa 1208401 atacggattg acttttcatt atgatgattt cagcgatgag gactgtttac gctctaagat 1208461 tacgccgaat acaaaagcgg tgtttgtgga aacgccgaca aaccccctca tgcaggaggc 1208521 ggacattgaa catattgccc ggattacaaa ggagcacggt cttctgctga tcgtagataa 1208581 tacattttat acaccggtct tgcagcggcc gcttgagctg ggagctgaca ttgtcattca 1208641 cagcgcaacc aagtatttag gcgggcataa cgatctgctt gctggacttg tcgtggtgaa 1208701 ggatgagcgg ctcggagagg aaatgtttca gcatcaaaat gcaatcggcg ccgtcctgcc 1208761 gccatttgat tcgtggcttc tgatgagagg aatgaagacg ctgagcctca gaatgcgcca 1208821 gcatcaggca aacgcgcagg agcttgcggc gtttttagaa gagcaggaag aaatttcgga 1208881 tgtgctgtat cccggaaaag gcggcatgct gtccttccgt ctgcaaaaag aagaatgggt 1208941 caatccgttt ttaaaagcac tgaagaccat ttgttttgca gaaagcctcg gcggggtgga 1209001 aagctttatt acataccctg cgacccagac gcacatggat attcctgaag agatccgcat 1209061 cgcaaacggg gtgtgcaatc ggttgctgcg cttttctgtc ggtattgaac atgcggaaga 1209121 tttaaaagag gatctaaaac aggcattatg tcaggtcaaa gagggagctg tttcatttga 1209181 gtaaacacaa ttggacgctg gaaacccagc tcgtgcacaa tccatttaaa acagacggcg 1209241 gaaccggggc agtcagtgta ccgattcagc acgcctcgac ttttcaccaa tcttcatttg 1209301 aagagttcgg ggcatatgat tacagccgct ctggcacgcc gacaagaaca gctctcgaag 1209361 aaacaattgc cgcactggaa ggcggaacaa gaggatttgc tttcagttca ggcatggctg 1209421 ccatctcaac agcattttta ctgctgtcac agggtgatca cgttcttgtg acagaagatg 1209481 tatacggcgg aaccttccgt atggtgacag aggtgctgac ccggtttggc attgagcata 1209541 cgtttgtcga catgacggat cgtaatgaag tggcgcggag catcaagccg aacacaaagg 1209601 tcatttatat ggagacgcca tcaaatccga cacttgggat tacggatatt aaagcagttg 1209661 ttcagcttgc aaaagaaaac ggctgcctga cctttctgga caatacattc atgacgccgg 1209721 cactgcagcg tccgcttgat ctcggcgtgg atattgtact tcacagcgcg acaaaattct 1209781 taagcggaca cagcgatgtg ctctcaggtt tggctgctgt caaagatgaa gagcttggga 1209841 agcagctgta taagctacaa aacgcgttcg gcgccgtcct tggcgtgcaa gattgctggc 1209901 ttgtcctgcg cggattaaaa acattgcagg tccgtttaga gaaagcgagt caaacagctc 1209961 agcggcttgc ggaatttttc cagaagcacc cggcggtcaa gcgcgtgtat tatccgggac 1210021 tggctgatca tcccggcgct gaaacccata aaagccagtc aacgggagcg ggcgccgtgc 1210081 tatcttttga gcttgaaagc aaagaggccg ttaagaagtt agtcgagaat gtgtcactcc 1210141 cagtcttcgc tgtcagcctt ggcgccgtgg aatcgatttt gtcctatccg gcaacgatgt 1210201 ctcatgcggc aatgcctaag gaagagcgtg aaaaacgcgg tatcactgat ggcctgctcc 1210261 gtctgagtgt cggcgtcgaa catgcagacg atttagaaca cgatttcgaa caagcgctga 1210321 aagaaattgc tccagtttcg gttcgttaaa aaagaagccg gggatagtcc ggcttctttt 1210381 attattgttc gtcatcagga ttcagaatcg cgaggacttg atgatcctcc caaacgccat 1210441 taatttttac attttttcgg gcgatgcctt ctttatgaaa tcccgctttt tctaaaacac 1210501 gcatggaccc gagattacgg ggcatcacac cggcttcaat ccgatgcagt ttcaattcgt 1210561 ggaacgcata atcaacaacc aatctgactg cctctgtcat aatgcccttt ccattatggg 1210621 ctttgtctaa aaaatacccg atgaacgcag tttgcagcgc gccacggatg atttgaaaga 1210681 gcgaaaccgt cccgattaat ctatcgtctg acgctgtaaa gatgccaaaa tgatattctt 1210741 catctttctc aagtctttcc tgatactcgg ttattcgttt tctttgcccc tcaaccgtat 1210801 agtaatcgtc tgcgcgtatc atagaaaact gttcgaaaaa atctcgattt tcgctttgca 1210861 gccccagatt ttcttcggca tccgttactt ctaaaggtct aacataaatg gtttttcctt 1210921 ttaacatata gtgatctctc cgttctcatg tcagcattcc tcttacatta ttctcaggga 1210981 aatgcaaata tcctttttat aagaaggaag aaaaccaatt tcccataaaa gtgccaacat 1211041 agttgccgat taagtagccg agcgtaccga caagcatgat cggggcgaca agctcccgcc 1211101 atcccttggc aattgccatc gcagccgcag tcgtcggtcc cccgacagta gcgttgacgg 1211161 cgagcagaat ttcttcaagc cgcacacgga acaattttcc ggcagctaag gaaaccgcta 1211221 aattgctaat cgcaatgata aacacgaata atagaataag aggcgcattc gtgacgatta 1211281 agcggagatc tgcaggaatg ccgatcacca caaaaaacaa ataaatcaaa aaggttccaa 1211341 gctcctgaga tccattgagc ctttcaaaaa aacgcgggaa aagaaaaatg ataagaacag 1211401 ttaaagacgt aagaaccagg tactgatcgc caagcgtacc ggtcagcagg ggatgagaaa 1211461 aaatgctttt aaaataaccg gaaaccttca tactaaccgc aacaagcgcg aaagcggcac 1211521 cggcattaaa agcgatatcc tttaaggaaa tatccttccg tttccaatag ctttcagcac 1211581 tgtttccgct gtttccatcg gcttttacct tctcttcaaa cggcatggca taatgccgct 1211641 gaaaccattt gagtgcagga atgctgatta aaataaaaaa caaaagcgcc atcataaaat 1211701 tatcagccac aacggtagcc gacacatatt caccaggcgt ctcaaatttt gccgccatcg 1211761 ccgcaaagtt gaccccgccg ccgatataag aggcgctgat catcccaccg attttatcta 1211821 agtaaggaat atgctgtttg agtagaaaaa aagccaggat actgccaagc actgttccaa 1211881 cggagctaat cagaaaaata aacagcaaac gcctgctttc cttaaaaatt tgcctaacat 1211941 tgatctgaaa caataaaagt ggtatcgcca gcggtaccac ataagaccac acagtgtcat 1212001 acacgggcga ctcaacagga agcactccta catttgtaaa caccatagca cctgcaaggg 1212061 cgataatagc gcccgacaca gcagacgccc acttaaagcg ctgctccagc ccgatgctca 1212121 ctgccgccca caccgcaata aacccccata atacccatac atcatcagaa gaaatcaaag 1212181 aatgcaaaac cccatcacct ctattgttag aaaattaaga catattataa tagccgggga 1212241 acggaacagc aagtccaaaa aaagtttttc taaaaaagca gttgacgaat agaaggtaag 1212301 gttatataat agaacttgtc agaaagataa caacataccc agcaacacat acatatcatg 1212361 attccgtagc tcagctggga gagcgctacc ttgacagggt agaggtcgct ggttcgagcc 1212421 cagtcggaat catagcttaa acccttgcgc agcaagggtt ttttactttg cgttaataaa 1212481 gccggttcgt caaattcgtg agttgttggc gaactgttgg cgaaattcat tgaccgcagt 1212541 ccaaaaacta cctccaaact tacttgatta gttcaatagt aacaaacgga agatcggatt 1212601 tctgttaaat cttcattgag aatagccagt ccaagaccgt cacttcagcc atgcatcttt 1212661 taaatgaaat tttgtactga aaacatcaat tgtattttta aattctgctc tagaatcagc 1212721 ccctttataa taatcttgat aaattgcttg gggtgatact gattcgtgat ttgtgctatg 1212781 gtttgcaagg cttgtagcaa aagcaggagc aacagtaacg agtaaagcaa gggataatgc 1212841 aaaaccagtt aaagcttttt caatttcatt ttaagcactt ctttttttaa aatacaactt 1212901 tattattaaa tggaatacaa aaacatccaa ggtgtttttt tgttagtaag ttgagttagg 1212961 gggattggat ggcacttaga atattgtttc tgctgatggg atgttgattc tggatatatt 1213021 tccaacacga ttacaggccg gacatgaaag cgaaccttgc tttgatcggg gcaatcattt 1213081 catttacggc tgcggtttac tttaaagata ttgatgtatt gagagaagag ggaaaacaaa 1213141 tgaacggaat ttctgagcgt tggaacacgt ttaaattaca aaaatcccct gaaccactct 1213201 agatcagggg attgctttcc caacagctta ttaagtagcg gaaggcatga tcaacgattt 1213261 agtatcaatt tattaattgc gaatactaga aacataccgt tttccgcctt ccttagaagt 1213321 aacatattct cgaggaacat taagtctatt ggtagaatga taacttacat aaagtttcat 1213381 atttgctcgg ctcgttacga tagccgtatg atccatccaa ccatcagcat agcgaagacc 1213441 tattttatta tggtaatcat agtgatatac atctccaagc tttacatttg aatatgtatc 1213501 agaaacagtc ttcattttta ttccgccagc ttttaaaatg tatgatctaa aggctcctgc 1213561 attaacccaa gcatctgtat agggtttcca ttctttaaag tacggcattc ttccagctct 1213621 taatgcttgg gaaacaaagt tagtacaatc tttgtcttta taatatttat agtttttatt 1213681 tggttttaag gcatattttt ctgcatattt cattgcagcg taaccactat atcctttaac 1213741 agatgttgca gtcacagtta gttgattaga gttagcagca ttgaagttca tacttactgg 1213801 tttatcttca cttttcactt cttctttatc atcatttttc acttcttgct tatatttttt 1213861 taaaaattca tctaatttaa catccgaaga atattcttca tcattttcat attgtagagt 1213921 tgaagaagaa ttatttaatt gtgttacatt tagttgctta gaagaattac tcaatggtat 1213981 tacatttagt tgattagaag aatttttaac ttgagagaaa cttagattag aagtatttgt 1214041 tgattgagaa ctttgtttat tagaagttgt tttgggaatt tcaagtttaa tattatcgcc 1214101 cagagatgtt gttacttttt caacaccaaa aacaaagttt cgagtaatat aagcttcaac 1214161 aattagctta ttgttttttt cagaagtctt aacatcgtct atatcgtatg taaactcgtg 1214221 gaatttttgt ttgtccactt tacttaacgc agaatacagt aagactcctt cgtcggaatc 1214281 agtcaattta gactctttag gatgcgctaa aggagtgttg tgttcaaaat catatttttg 1214341 ttgttctaac atatccttaa ctttttcgta accaatctcg ttggtaattg aaacattttc 1214401 tttagtctct ttattagtag tggctgcaaa aacttcattt gttgacacta atggtgacaa 1214461 tgatagacat aaaactagtg aagcaagtaa ttcttttttc atacgaaacc tccaataaaa 1214521 tctaaatata agtaatattt atcatttaca ccaattgaaa tatggcataa aatacatgta 1214581 ataatataac ataaaaataa atacataaaa aggtatcgga ggaaaaaatg aaaaagaaaa 1214641 ctaaaattat actttctctc ttggcagcac ttattgttat attgatagta cttccagttc 1214701 tatctcctgt tgtctttaca gcttcttcgg aaaaaggagc aatcagacac gaaatttata 1214761 aaagaggata tccctaccaa agctactttg cagttctcca gaaaagagaa ggagacaatg 1214821 aatctgggaa tctttattat gtaaattggc tagattggaa agatgaaaca gggcaaactc 1214881 ctcacttatg ctattcgaaa aaatcatcag atggtgaata cgaagtaagt tgtggcacag 1214941 ggccgtaaaa ataaatttta aaattgaata agtccaagac ggaaagcctg cggacactga 1215001 tcgttttaca gagaaatttg tgcttcgatc ggtgtccgtt ttttttcgca actaaccaga 1215061 tgtctatcgc gattactagc tatgaaagga gtaattagac atgaaacagt ccaaaaagaa 1215121 accatcacag aagcaacatg agcgcttaga tcgtttctgg caacaaatga tgaacactaa 1215181 catgcaaaca ctcagacgtg gcaaaggcgg cgcttataaa cgcagaaagt aaaaagggag 1215241 tttgaggatg atgaaaaacg gattcgctta taaaaacgga aagcttgtga atatcttttg 1215301 cggcaaagaa gagctctata acgagttgaa agccttcttg gtcaaaacct tcagtatcaa 1215361 cgtgaaagag gtatcgaggc cctcaatata tcgcagaaca aaaagcaaac aactggaatg 1215421 acacttactc tatttaacta tcaggaggga aagcactatg acagatcaaa tgattgcatg 1215481 ggagattgag gaatggattc gtgattataa attcatgctg cgggagatca aaaggctcaa 1215541 ccgtgtatta aacaaagtgg attttattag cacaaagctc actgcaacat acggggagga 1215601 agcgggcatg ccaaggggat cagcaggcgt cagtcaggca gaattgcggc agatggaccg 1215661 aagagaaagg cggcttcaca aatatgaatc tattgtgcat tacctggaca atgcaatgga 1215721 acacattgaa gaagaaaagc accgaatcgt ttacgattgc atgatggaag gcatgagcta 1215781 cactgctatt gcaaaccacc ttgattgctc ccgggatacc atcagaaaga tcaaaacagc 1215841 cataatcggc aacatcgtca ataaagtcaa agaagccaac tttctgcaat atttgaattc 1215901 gtttaaatcg gcggtgtaaa atggggggca ggatcggcgc ggcggattat tcctgcgtca 1215961 ccaccaattt catacaatga gtaaaacctc ccagtggtaa gcgaggatca actcaactgg 1216021 gaggtcttac atagtgaatc ggtgataaaa cagcagcagt attgcgtaca tgttaatatc 1216081 cccgacaaaa tatgtttttt tcaacagatt cgttcgacaa attttgcaaa ttgttaatcg 1216141 ataacttttc attcccgata ttaaaaatgg gagtgaattg taaaatgaaa aaacagaaaa 1216201 ataataaaaa gaagaatatt gaaaagcgaa atattgaaaa gcgaaatatt gaagagaaga 1216261 ataatgagga cttagaagaa ctggaaaatg cgatttatac ttatcacaaa aaggagctac 1216321 ttgctttctt tcttgaaaaa actcgaattg gtcatgataa ggaagaatac aaaaggttcc 1216381 aatctcttct ttataagttg gatattgaat gtttagaatt tgctatatcg agattttctc 1216441 atatagatat tatccatgat cattcaaaat atgttccagc ctttatccct ttatttgcag 1216501 catatctcac catgttcttt aatttttatg aaaaacattg gggagcttta tcttttgctg 1216561 ctggtacaat tgctgctatt gtttggataa ttgcagtaga aagaaaacat agaaatcaag 1216621 caatttctat tatgaaaata tttgaacaag tcaaagagag aaaagtgaaa gacagatcta 1216681 aagactgaaa ggagaaaata tgaataagga taaattaagg tatgcaatct taaaagaaat 1216741 ttttgaaggt aatacccctt tgtcagaaaa cgatattgga gttactgaag atcaatttga 1216801 tgatgctgtg aactttttaa aacgcgaagg gtatatcatt ggggtccatt attcagatga 1216861 tagacctcat ttatacaaat taggacctga actgacagag aaaggtgaaa actacttgaa 1216921 agagaatgga acatggtcta aggcctataa gaccattaaa gagattaaag attggattaa 1216981 ataataagag catcctgcgg ggtgcttttt ttgttccctg taaactgctt ccggtaagtc 1217041 tcaggataga caattggcgg ttaacggctt gagcacggtg gtggtttaga gggaatatct 1217101 tttccaaaac aacacgaatc agaagggggc ggcggtgaat gtagatggcc gaaaagcaca 1217161 ttcaggcgta taaggattac gtcaaaggca tgaaatacaa ggaccttgcc gagaaatacg 1217221 gggtgtcagt gaacaccatt aaatcgtgga agcagcggca tggttgggaa aggaaaaagg 1217281 gtgcacccat tgaaaaaagt gtgcacacaa aaaaaggcgg gcaaccgggc aacaaaaatg 1217341 cattagggaa caatggcggc gcaccacaga agaatcaaaa tgctgtgact cacggctttt 1217401 tctctaaatt cttgccagaa gagacgcttg aaatcatgga agagattcag gagcgttcgc 1217461 cagctgatat gatatgggat cagatacaga ttcaatatgc ggccattctt cgggcgcaaa 1217521 agatcatgtt cgtttctgat aaggaagaaa tgatcaaaga gctgaaaaag aaaaggtccc 1217581 tcatatctga ggtcagcgaa attgaagatg ggcttgtcat tagttttagt acgtggtttc 1217641 gctacagact ttacagtgaa acaaacacct aacacatttc acattgcttc agattgcctt 1217701 caaacttgat aatataactt ctaaaccttc ctataaaatg aaggtttttt atttgatttc 1217761 aatttttaaa tcctttacat acagcgattg attaactcga gcaatcaatg tcgcagttat 1217821 atttattttt caagaaaatg ttataatgaa aagccataaa atgatgggag ggggaatttc 1217881 gatgcattac ataacggcat gtttaaaaat catcagtgat aaagacctta atgagataat 1217941 gaaggaattc aaaaaacttg aggaagaaac gaacaaagaa gagggttgta ttacattcca 1218001 tgcttatccg cttgagccat cagaacgtaa aataatgctt tgggagattt gggaaaacga 1218061 agaagctgtg aaaatccatt tcacaaaaaa acacacaata gacgttcaaa aacaagaatt 1218121 aacggaagta gaatggttaa tgaaaagcaa tgtgaatgat tgaaaggctc tttaaaaaga 1218181 gacattcaat gacttagtat cagccacttg tgactaagta gtaaattgtt gtccaactct 1218241 tattttttct atttaatatt ttttgagacg aaaatgtttt tttaagctga ttttaaaatg 1218301 tattcaaagt cagctctgtt tgatttaatg gattatatta tttggatagc ttgttaccat 1218361 cataatggag atactcctta taaattggag gttaaaataa tgagtcattc tcaagaaaaa 1218421 attgcactaa ttacaggagc aagcagtcaa ggggatattg gtacggctat ttgtcgtaag 1218481 ttagcctcac agggtataca tatcttcttt actcactgga attctgatac ggcctggata 1218541 gaagaatttc aacaagaaat tttacgtatg ggtgtccgct gtgaggcaat gaaaattgat 1218601 ttatcagatg cacatgctgc attcacaata catgaaaaaa tttcagataa attaggatat 1218661 ccttccatcc ttattaataa tgcagctcat tccgcaagtg ataattatgt atcgttagat 1218721 gctaaatcac ttgatgagca ttatgcggtt aatatgagat cgaattttct tctttgtgtt 1218781 gaattcgccc gtcggtttaa aaaatctaat ttaatatcag gaagaatcat caatatgaca 1218841 tcagggcagg atttaggtcc tttgcctggg gagttagcgt atgcagcaac taaaggagct 1218901 atttctgcat ttactaggtc gttatcacaa gaacttgcac cattgggcat cactgttaac 1218961 gccgtaaacc caggtccaac agattctaca tggatgacag atgaaataag aaattttctt 1219021 tcacctaaat ttccaatggg gcgtattggc acaccagatg atgcagcacg aatgattgcc 1219081 tttcttgcaa gtgatgaggc tgaatggata actggacaaa ttattcattc agaaggtgga 1219141 tttattcggg gctaagctaa tgaaacacgg tatacaccaa tgtatgatgt attcccaaaa 1219201 ctaaatctaa acttgaagcg aaaataaggt cccttctctt tttagagggg gaccttattt 1219261 tattcatgca tgttttgcat ccagaaaatc tggcggataa agattaataa accgttacat 1219321 atacttttcc gaatactgca gtacctttaa acaaagtaat cgtggctttc ccttttgatt 1219381 tagccgtcac taaaccattt tgatcgactt cagcaacttt ttggttatca gtccaataac 1219441 gagtagctga attattttta acagaatagg tttctccaac ttttagaggt aaattatagt 1219501 cttgaatctt gataacatgt gtaggtgaaa tagaaatgtt ctttacttca gtaggtgtgg 1219561 agtttatttc atgagctgaa gctaccccgc tgaccgacag agctaacgca gaaatcgata 1219621 aagcagaaac aaccgttttt ttgaaattca ttttgaaaca ctcctttaaa gttttttgtc 1219681 ttgcactata acaattcaat aaaagtaatt attttccttg taaataaatg ttaataatat 1219741 gtgaacgatc aattgatttg agctaagaat attgtgtgcc ctgcacagag tttgtattta 1219801 tgatggaaaa ttgctgagag agaatggcca tccttaaaat gttaatagca cacatttgat 1219861 gggtattagt ttgttgagcg tgtggaaatt ttgttacctg cactttatcc ccgaagatac 1219921 caaatcactt ttcttcatca tgttcttact ttcgtactca tacattagaa aatcttcgtt 1219981 ctaaataggt gaagaattgg agtattttta tgaatttctg ctgaatatac attacatagc 1220041 aaactcaaag agtataaaaa tcgctttttt ccggaagctt cggtaaaaaa cgaaactttt 1220101 gtctctatga ttttgtttta taatgtaaac ggtttcttat atagtatact tatactatca 1220161 atttgctcaa gtagatactg acaggaagga tagaaaaaca gatggaatac ataaatacaa 1220221 gacaaaaaga gattttgtat ctgttgttat ctgaacctga tgactattta gttgtgcaag 1220281 atttcgcaga tagggtacag tgttctgaaa aaacaatccg gaatgatttg aaagtgatcg 1220341 aggattatct caatgagcat tctcatgcac agcttattcg aaaaccaggg ttgggcgttt 1220401 atttacatat agaagaacag gaaaggacct ggctaagcca acaattacat actgaacatt 1220461 tttcttctag gcagcggagc gataaggaaa gaatgctgca cattgcttat gacttattaa 1220521 tgaatccgaa gcctgtttcc gcaaaagaca ttgccgctcg gcattttgtc aatcgatctt 1220581 ccattaaaaa ggatttatac gcagtagaag agtggctgaa gcgttttgat ctcacactgg 1220641 tttctaggca gcggcttgga ttaaaggttg aagggaacga aagaaataaa agaaaggcat 1220701 tggcaagaat atctgatttg attcacaata cagcgtttac cagccaattt attaaaagta 1220761 agtttttaca ttatgaagta gactttgtga cgaaagaaat caaatcacta caaaaaaagc 1220821 attccctcta tttcacagac gaaacgtttg aaagtttgtt gctgcataca ttgttaatgg 1220881 tccgccgcat caaaatgaag cagccgattt cattgtcccc aaaagaaatg gcggcagtaa 1220941 aaaagaagaa agaatatcaa tggacatttg cttgtttaca gcggcttgaa ccggtttttg 1221001 caattcgctt ccctgaagaa gaagccgtgt acttaacatt acatatattg ggcggtaagg 1221061 ttcgttatcc attgcagaca gaagagaacc ttgaaaatgc tgtgcttcct aaggttgtag 1221121 ggcatttaat caatcgtgtt tcagagctga aaatgatgga ttttcacaag gatcaggatt 1221181 tgatcaatgg tttgaacatt catctcaata ctgtgctaca acggctgagc tacgatcttt 1221241 ctgtagcaaa tcctatgctc aatgacatca aaaagatgta cccttatttg ttccacctca 1221301 tcattgatgt tttggaagac atcaatcaaa cttttgatct tcatattcct gaggaagagg 1221361 cagcatattt gacattgcat tttcaggcag cgatcgaacg gatgcagggc agcagcgaga 1221421 cacataaaaa ggcggttatc gtctgccaca tggggattgg gatgtcacaa ttgctgcgga 1221481 caaaaattga acggaaatat caccaaatcg ctgtaatggc ttgtattgca aaggccgatt 1221541 taaaggatta tatcaaaaag catgaggata ttgatcttgt catatccacc attgcgctgg 1221601 agaatataac ggttccccat attgttgtgt ctccgctttt agagcctggc gaagagaaga 1221661 aattaagtgc gtttatacgt cagctgggcg aatcacaccg ccaaaaacaa aaaacgtttc 1221721 agatgctgaa caatacgact ccttttttgg tttttttgca gcaggaggcg gagcatcgct 1221781 acaagttaat cgaacagctg gcgacagctt tgtttgagaa aggctatgtt gataaggact 1221841 atgcggttca tgcggtgatg agggaaaaaa tgtcggctac aaatattggg tcaggcattg 1221901 ccattcctca tgcaaacgct aaatttatta aacaatcagc aatcgcgatt gccacattaa 1221961 aggagccgct tgaatgggga aatgaaaaag tttcgctcgt ttttatgctg gctgtcaaac 1222021 acgaggatca aactatgaca aagcagctgt ttagcgagct ttcatatctt agcgagcagc 1222081 cggccttcgt ccagaagctg acgaaagaaa ccaatgtcat gacattttta tctcatttgg 1222141 attattaaaa gcagggatta ttccttgctt tttttgttca tggcagggct tgagaaataa 1222201 atttgcgagt gaagacgcct attctccagc aatgatctaa ataaaataag agtttaatag 1222261 ttggagaaga aatgttacac tcttttctgt atatggtaaa gaatgaaaaa acacgattcg 1222321 gttggtagtc cggatgcatg attgagaatg tcagtaacct tcccctcctc gggatgtcca 1222381 tcattcttta atatctttta tgaggaggga atcgttatga aattaacgat ttactacgat 1222441 ggtcagtttt gggtaggcgt tgttgaagtt gtggacaatg gaaagctaag agcctttcgt 1222501 catctttttg gcaaagagcc gagggattct gaagtattag agtttgttca taaccaactt 1222561 ttgaatatga tggcccaagc tgagcaggaa ggagtgcgtt tacaaggcag gcgtcaaaaa 1222621 aagatcaatc caaaaagatt gcagcgccag gtttcaaaag agttgaaaaa cgccggagta 1222681 acttctaaag ctcaagaggc gataaagcta gagcttgaag caagaaagca aaagaaaaaa 1222741 caaataatga aagaacaacg agaacatgta aaagagcaaa ggtatatgct caaaaagcaa 1222801 aaagcgaaaa agaagcacag aggtaaataa tccaaacaaa agcaggcgca gtgcctgctt 1222861 ttgtaattaa ggactctact ttgtaacata tatccaatgt ttatactccg ctgatttatg 1222921 attcaatata aaccctaact tctccaaggt tttttgtgag cctagattat catgttcgca 1222981 tcttgcggtg atccgggata ctgtttctcg gcttaatgcc cagtttatta gtttttgggc 1223041 ggcttccaca caataacctt tgcggcgatg acttttattt gttgcaaaac cgatttcaat 1223101 catgccattt tcgtctgggt cacctaaaaa tccagttccc ccaacaattt cataattgtc 1223161 cttctttaca ataatccatg aatcaaatcc ttttgttcca ttgtttttga ctaaaatctc 1223221 gcggaaataa ggtatcgctt caaaaaaatc agaatttggc cattcaccat ttgtttcata 1223281 gcctaattct ttgatagcct gatgatcttg tttagacgcg gcgtcaagaa ggggaatatc 1223341 aatcgtttgt aatcgtaatc gattcgtttc aaggagaacc atatatttaa tcctcttttc 1223401 tttttactgg gaataatgat aacatataac aattttctct ggtaccttgg cagtagagaa 1223461 agatgaaaaa attgaggggg attgaaagag tgacaggtga gagtttgccc agaccaaaaa 1223521 cgggtaggaa aatgctgatg ttaatgtgtc cctacccgtt tttctgttcc tgaatgcagg 1223581 gtttctgata acatgttgtg ctaccttttc gcaatcaaat aaagcgatat ggctctttgg 1223641 gtttgcacag gattatgaat gataatgacc cattggtttc ttcgtcttgg aaagcttgct 1223701 accgcataca atggagcagt atcgcgcgga gtgaacccac catttatcac gttgatatct 1223761 cttccttcaa gatgacaaac taagtattca cctggattga tgacctgttg gttcgtccat 1223821 gcgtaagaat aaaagccgtc tccaagatct tcggtggaag atggggggac aaagccatct 1223881 acagtcaatg tgatttctct tcttcgctgt ctttctgaaa agtctggact tctttgaggg 1223941 ttatgagtat gtgaaaagta aggaattaac gcagggccat aaaagtaatg atacaaagca 1224001 accactcctt tattttccat tcatacaaat tgtatgtggg agttatttgt tcattcctgt 1224061 tttgttccat gtagactaat aatgggctat aggcgtccaa ggaaatcaat ttgtccttcc 1224121 gttgattcaa tgctagtaac cttgaaaatg caggttagga tgatagaatt tacatattac 1224181 tgcaagaagt tagacataca tcattttgat agtgggtgaa aacaatggcg aaaaaaatgg 1224241 caaaaacaaa tgcggttcgt ctgatagaac agcagaacat ctcttatgag gtattagggt 1224301 ataaaacaga cggccagccg gtagatggca tctctgttgc ggaaaaaatc ggttattctt 1224361 tgaaatatgt atataaaacg ttggttgcag cagcaggaac aaatcattat tatgtctttg 1224421 ttgtacccgt tgcagaagag ttagatgtaa aaaaggcagc aaaggtgaca ggggaaaaga 1224481 aaatagaaat gattgcaatg aaggagctgt tagcggtaac tggctatctt cgcggcggct 1224541 gctcgccaat tggcatgaaa aaattgttcc cgacctatat tgatgcatct gcagaaacgc 1224601 ttgattttat tattgtcagt gcagggaaaa tcggtatgca gctaaagttg gcgccacaag 1224661 atttagccag atcatgtgat gccgcatttg cagaaattgt atagatgcag atatagggga 1224721 acgaaaaagc ttagtcatat cgattaagct ttttccgcat ccctttcaaa tatgatttca 1224781 aaataagcag ctgccccata cccatctata ctgggagcga aaatctgaac gaatctccag 1224841 cctcttttcg cataatcatg gatgatttgc tggtagtctt ctttaggcct tcttctcatc 1224901 gtactcagct caactcttac gaattcatat tctttcatcg tttgatccct cctattaagg 1224961 tatacgtaaa atggagcgag aagttccgaa aacctaggtt aaggtcggaa agtatatttc 1225021 actcactaaa caaatccatt tatgcctgat gcctgcatgc atctgggaag agttaagggg 1225081 ctataaaaac gaattttacc gggtcagcag tccaaatgaa tctcttgctt attgcatttg 1225141 actgagtata taagtaaaaa aagagcggcc agaacatata agaaggagat gatcattaac 1225201 gcactcataa cagggtagtg tttagcggag tagatgaaaa aatcaagctg tgaaatttgt 1225261 ttggggctgc tgacggcatc aattccatta agcagttttg agagtttagc agtatagttc 1225321 caatcaaatc gatctgaaac aagctcgctt ccttgatacc aattaacagc agctaaaaac 1225381 agaaatacca taatagaaaa tccaagctga acaactaaaa atattccctt cacttttgta 1225441 tgacctccaa atctatgaat atgggaaaat caaacaatat attaccaccg tatgggttat 1225501 tcttgcaatt tcacttccat acaactcaaa cgcaagtcta tttttttgtt tgtttttggc 1225561 ttataatacc tgatgatgga aaaagagtgc gggtttatag attagagaaa caaatgtatt 1225621 tcttagcatt ttttatttgt ggagagagta tagaagcatt cgattagatc tgctttttca 1225681 cagaaacggt tttcatctgt ttgcctgagc tttacaattg gctggcaaaa aaacaatgat 1225741 ttctttcaat caaaacatgc aacgatgcga cacattttat atcttgatga cttatttcat 1225801 tgcctttaag tcatcctatc gagaaagcga tggtatttta tgaacaaaga aaccctaaaa 1225861 aacatactca tgattttttc aatatgcgca acactccgag aaaccgatgg tatgcgcata 1225921 gctgatagct ggattttgag tgagattata cgatttttga tttgcatggt tgtgtttttt 1225981 gccatgacat ttctattaga tgctgttttt ccaaacaaaa aagagtcaca ttaatgtgtg 1226041 gctctttttg catcatctga tcagaaacat cataaatgaa tcgatcatca tgatgaagaa 1226101 cagcaagcaa aaataaataa gcgagtagac aaacatatcc tttgcccact tcacgtcatc 1226161 gtctgttttg aatcctttga tgcttttttt gatccatatg cctccgagaa ccaaggcggc 1226221 taagaaataa aatgggctta tatggccggt gccgagagag aaaggaaata atagcgtgac 1226281 cggcaccagg acggcaatat attgcatcat ttttattttt gttacatgat tgcctttgac 1226341 tactggcaag agcggaacgc cagcagcgcg atattcctct ttgcgtctta tcccaatcgc 1226401 ccaaaaatgc ggcggctgcc acagaaacat aatcgtgtac aacagcactg ctgtcatact 1226461 gaagtcaccg gttacggcac aataccccat caatggcggc gcagctcctg ggaagctccc 1226521 gacaaatgtg ctccacacag acgttcgttt cacccatacc gtatagatga tcgcataaaa 1226581 aataaaggcg gccagtccga gaaaggccgt taatggattg agggaataaa gcatggcaag 1226641 acctgcgatt cctaaaacag agccatatgt taagatcatg gctggcggca ttttccctgt 1226701 gaccgaggcc ctgctgcgag ttcgtgccat ttttgcgtcc atatgccgat caaaatagtt 1226761 gttatagaca gtgccggaag ccatcacaaa cgcggttccc aacattgctg ttaccattgt 1226821 catcaaaaaa gccaagccgg ttaacgtttt ttctgcgctt gcaaacgcga tccaaaaccc 1226881 gccgaaggct gctatcgagt ttgatatgat aatgcccggc tttgcaagtt tgataaaatc 1226941 gtaaatggtt acccggttcg aagcttttat gtattttgtt tcagatatgg ctgcagaatc 1227001 tcttgtattc tccaaaaata gacgcctccc ccaaaactgc atgcttttgt tatcgtaaca 1227061 agagggggac agaatcacaa ttatttccca tatttgtcat gatattgtca tttttaaaac 1227121 aaaaaaatgg ggagctggac tgcccccatt ttgatatgtg gcgactagta accgtaacct 1227181 cccccatatc ctccgccata acctccgccg taaccgtacc aagggtagta aggcggtcgc 1227241 gggcgcgggt agtaataagg cgggcgcgga taaaacgggt agaacggata atacggtctt 1227301 ggataataat aaggcggata aaatggcggt ctcggacgcg gataataata aggctgtctt 1227361 tcatcataag gggtaatttg ttcaaatgac tgttcattca aagggtaatc caagaggaaa 1227421 acctccctag ctttttttat tccttttacc atattcctga tgcttaagtt gggtgtatgt 1227481 acattcatga aattcggttt tttttatgat gaaattcctt aaaaaggatt gacatgaact 1227541 tctaaatctc atagtattac aaatgtgaaa taaatgttac tacaatgtta caaaaacatt 1227601 tctaaataga tacagttcca actgatgaag agtaaatcga aatggctacg aaagaaggag 1227661 tttttgttgt tggcaaaaag aatcaaatgg tttcatgtat taatagcagt tgtatgtgtg 1227721 gtgggcctta tcggcttttt ccataatcat tcattgaaaa aagaaacggt catgaataaa 1227781 gtaagaactg attctcaata tgggaatgtt gagatcgcaa cgcttgtgaa tgacgggaaa 1227841 acttttaatt acgcggtaaa ctatcctgtt ttcaaaaatg aaaaaatgga ttcggcatta 1227901 aaaagattcg cagaaaaaga ggttcgtcaa tttcaaaagg aaacaaagga cgttgaccaa 1227961 gagcatacga caaaacgcaa cgaattaaat gttgattata aaattgtcca ttatgccaaa 1228021 cagacagtgg cgattgtatt taatgaatat aaatacatcg gcggggcaca cgggcaaacc 1228081 gtgaaaaaaa cgtttaacta tgattttagt aaacaagcgt ttctttccat tgatgatatt 1228141 ttcaaagagg acgctgacta cttacataag ctttcgttaa tcgcttatca cgagctgaaa 1228201 aagaataagg acattgccgc ggacgatgca ctgttaaagg aagggacggc tccgaaaaaa 1228261 gaaaatttca gccgctttgc catcaaggag gattatatcg aactttactt tgacacatat 1228321 caggttgcag caggctatct tggagagcaa tcgattgcca ttaagaaaag tcttttgaaa 1228381 gacattctga aagaacaata tattgataaa gcaaaaaata aaaataaaat caaagaacaa 1228441 aagccgaagc atgaagtgat ttctttaccc aaagaggaaa cagttgatcc aaatcaaaaa 1228501 gtcattgcgc ttactttcga cgacggcccg aatcctgcga caacaaatca gattctagac 1228561 tccttgaaga aatataaggg tcatgccacg ttttttgttt tggggagcag agttcaatat 1228621 tatccggaaa cgctaataag aatgctgaaa gaaggaaatg aggttgggaa ccattcatgg 1228681 agccatccgc ttctcacaag gctttcagtg aaagaagcgt taaagcagat caatgatacg 1228741 caagacatca ttgaaaaaat aagcggatat cgtccgacgc ttgtaagacc cccatacggc 1228801 ggcattaatg atgaactgcg gagtcaaatg aaaatggatg ttgcgttatg ggatgttgac 1228861 ccggaagatt ggaaagaccg taacaaaaaa acaattgttg accgtgtcat gaatcaggcg 1228921 ggagatggaa gaaccatttt gattcacgat atttaccgca cctctgctga tgcggccgat 1228981 gaaattataa aaaagctcac cgatcaaggc tatcaattgg tgacagtttc tcagcttgaa 1229041 gaggttaaaa aacaaagaga agcgaaataa attagaaaag gctgtccgta cggacagcct 1229101 tttttctatt taataagagc ctgtggtggc ccaaacattt aagtttggtc ctgaatactt 1229161 gccgaaagcg taagaagtcc ttggatctaa atcatatacc atcggtgtat agcaagactt 1229221 ttggccggcc accgcttttc cattgccgcc tgcagaatca caattatatc tttttccgtc 1229281 tgtgttccgg gtaatctccg catttgcttc atagccagac gtcaatgtat tattcatcgt 1229341 gatttttgcc caagccgttt tacatgtact gctgaattta agctcgacta ctccgatgac 1229401 ttgattgctg gcattcacta agtttgagga tttttttgta gagccgctgg acgcacaatc 1229461 attgtaataa gggctttttc catcgtaggc atgggtttcc gccttggcgg gtgcaccttt 1229521 gacggcaaaa acaaatacta ctgcgaataa caccaatgaa gccttcataa acagtctttt 1229581 caatttatga cctccttaat atggcaaaca ataaatcata tggaggaaca atcaaaacat 1229641 gcatgctttt ttgtgaacaa taaaggcggc cgggaggatg gagttcttgg ccgcctctgg 1229701 tatgaggtta tgcttttaca tcaatggttt gtccgagagt tggatgttga atcatcttta 1229761 aggtttgatc ggcattttgc tgggcggtgt ccagcctttt tttcgttaaa gcaatattta 1229821 cattctgggc aagggatgct tgatgcatcg caaccgataa agcaggaata tccatggttc 1229881 cacctcctat gccttaccta tcggcgggtt tgtatgattt tacagtgaaa aatggcttaa 1229941 tttctcttgt tgacccttac gctgcggcat atcgtatgtt tttgacaagg agggaatcag 1230001 gatgaatcta gtaatggaaa agacctttga gcaatacgaa aagctgtttt caatggaaga 1230061 acagaaaaga gaagatgtat ttcggtatac gatgatgagg ccgtttgaaa agatgtggac 1230121 cgccatccaa gttccgctga aagcgaagga gccaaacggc tatgatgtga tcatggctgc 1230181 gaaaatgctg ggctatttgg atgtccgtga tgctgaaagc ggccagaaag cactacaaat 1230241 actgaaagaa tcacatgttt cagagacagc tgaatctgca cttcggcaat gcatattttt 1230301 tgctgagcgc gaacagctgc gggtgaatgc aaaggagatc aaattcggcc tttatatcgc 1230361 tgatccaaat aagcttcagc tgcaaaaagg ctactgcggg tttggcggga taccgggctt 1230421 tattcatgta tggattaatc cgaacagtta taacctgcca aggattcctt ccattattgc 1230481 tcatgagttt catcataatg tgcggttttc gtatatagat tttcatcatg gctctgtaag 1230541 tgtcggggat tatcttgtga ttgaaggatt ggcggaatca ttcgccagag agctgtttgg 1230601 tacggaacga ttgggccctt gggtaactcg ttttgatcat gaagacttgc aatattccat 1230661 tgatgtgatt aatgaggtgc tggatgtgaa aggattttcg gaagtcagcc gttatatgtt 1230721 tggtgatcca attgctaacg accaaggctt taagcctgca ggtttatcgg cttttgcggg 1230781 ttatgcagtt ggctatcatg ccgttcagtc atttatgaat caacatcata tcacgataag 1230841 cgaggccaca cgtttggatg cgaagaccat tatttctcaa tgcggtctgt tttctacatg 1230901 aaaaaagcgt cacatacagc ggcgcttttt gattcccaaa accagcagtt ctatggcggc 1230961 acaggcggca attccgattg tatatgcttc gatatcgctc cataaaaaac cgtaccctag 1231021 tacaagcccg ccaagagaag tatctctaat ctggtcgatc cattcggcat gatagagctg 1231081 gctgaattca atgacaaaac agaaagaaag actgataatg cccgttatca ttgtcttcag 1231141 cttccgaaat agaaatccgc atcccgtgaa gatcatggcg gcccacaacg agtctcccag 1231201 ataagtattg agggtatcag gaagaacact ggagaatgct ctggatccaa gccccagccc 1231261 aatgatcagt atggtgaaaa ctgcatatat ccaacgattt cgcttcattg cgaattgata 1231321 ccccgtctct gcttcatctc cctgtattgt aaggaatata gcttttattt gtccactaaa 1231381 aaagcggctg aatagccgcg tagggtgttt attttgcttt taggtttaca tggtcggctg 1231441 tctgatccgt gcctattaca aaatggagtt catagcggcc tgtatcatat acataatcga 1231501 tttcatcggt aaacgggacg gttaacaccc gatttactgg tcctaattgc ttctgcagca 1231561 cttccggcgt aactccgcct aaattcagct gccgttccac accggttcca aagtagcgga 1231621 tttctgaaat tgtcatgtct ttatgatagg aaaatccgta gcccggctgt cccatattcc 1231681 agtgatataa atcaaatcga ttgtctcccc cgactggtct ttccggttcc ccaaacgcag 1231741 cgtggacatc cccttttgtg cttttgttaa tggtaaggcc ttgcgcctgc tgaggcattt 1231801 cccctttata ggcggtgtta tagaggtttt tgacaagctc agcggctgat tgattcgtgt 1231861 tttctgagag tgtgtttgtt tgagctgcgg cctttgccgg tgctgaaaag gacgcagccc 1231921 caaagccggt aaaacagctt gttactgctg ctgccgcggt tatagcagac attgtctttt 1231981 tcatgttaat ccctcctaat tgatctacca ttccgtttcc ccgtgttttt gcaacgaaac 1232041 atgtgagtgc gctttgtatg ttttattgag ttgttgtaag ggaactgaaa taggtaattc 1232101 ggtatataaa gcaagaaagg ggaatggaga tggctggcaa gaaaacaatc acaataaacg 1232161 gcgttgaaat ggaagcgtcc gaggaacaga cggtgctgca gcttttgaat aacagctcga 1232221 ttgaagtgcc gcaagtttgc tatcatccaa gcttagggcc gattgagaca tgtgatacgt 1232281 gcatcgtcag catcaatggt gagctgaaga ggtcgtgctc cgctgaatta aaggatgggg 1232341 atgtcattga tacgctctca cctgacgtga aaaaagcgca ggtcatcggg atggacaaga 1232401 ttttatataa tcatgagctt tattgtacag tttgcgatta caacaatggg ggatgcgaaa 1232461 tacataatac ggtgaaggaa atgaaaatca atcaccaaag cattccgttt gatcacaagc 1232521 cataccataa ggatgaatcc catccgtttt atcggtatga tccagatcaa tgtatattgt 1232581 gcggacgctg tgttgaggca tgccaagacg ttcaggtaac tgaaacgctg accattgact 1232641 gggagcggaa acgcccgcgc gtcatttggg ataacgacgt gccgatcaat gagtcgtcat 1232701 gtgtgtcatg cggccattgt tcaacggtct gtccgtgcaa cgcgatgatg gaaaaaggaa 1232761 tggaagggga agccggatat ttaacaggca tcaataacga aacgctgcga ccgatgatcg 1232821 agatcacgaa aggcgtagag acaggctacg gctcgattct cgcgatttct gatatggaat 1232881 cggccatgcg tgatgaacga atcaaaaaaa cgaaaaccgt ctgcacgtat tgcggcgtcg 1232941 gctgcagctt tgatgtctgg acaaagggca gagacattct gaaagtagag ccgcaggagg 1233001 aagcgcctgc caacggcatt tctacttgtg tgaaaggcaa gttcggctgg gatttcgtta 1233061 acagcgaaga acgcctgaca aagccgctga tccgtgaagg cgatcatttc cgtgaagcag 1233121 agtgggagga ggcgttattg ctgatcgcca gcaagttcac tgaattaaaa gaggcgtttg 1233181 gcccggattc tctcgctttt attacatctt ctaaatgtac aaatgaagaa tcctatctta 1233241 tgcaaaagct ggccagaggg gtcattggca caaataatgt ggacaactgc tctcgctatt 1233301 gccaatctcc tgcgactgcc ggcctgttcc ggacagtcgg ctatggcggt gattcaggat 1233361 caattacaga tatcgcgcaa gcggaccttg ttttgattat cggttcgaac acgtctgagt 1233421 cgcatccagt cttatccact cggattaaac gggctcataa gctgagaggg cagaaagtga 1233481 tcgtcgcgga tatcagaaag cacgaaatgg cagagcgctc agatttattt gtccagccgc 1233541 gtgccggatc ggatatcgtc tggctgaatg cgatcgccaa atatttaata gaaaacggca 1233601 aggccgatga acgatttttg agagaaagag tgaacggacg ggatgaatat gtaaaaagcc 1233661 tcgcgccgta cacacttgaa tatgctgagg agaaaaccgg gattgatcaa gaaaccctta 1233721 tccaaatggc agagatgatc gggcaagctg acagtgtgtg cgcattgtgg gcgatgggcg 1233781 tgacacagca tattggagga agcgacacga gcacggcgat ctctaatctg ctgcttgtga 1233841 caggaaacta cggaaaaccg ggagcaggtt cttacccatt gcgcggccat aacaacgtgc 1233901 agggagcaag tgactttggg agtatgcctg acagactacc gggctatgaa aaagtgacgg 1233961 acgaacaagt ccgccaaaaa tacgagcgtg tgtggggtgt gccgctgccg aaggagccgg 1234021 gtatgaccaa ccacgaaatg attgaaaaaa tccattccgg acagttgaaa gcgatgtatg 1234081 taaaaggtga agaaatgggc cttgtcgact ccaatatcaa tcatgtacac gctgcatatg 1234141 aaaagcttga tttctttgtg gtgcaggaca ttttcctttc acgtacagcg gagtttgctg 1234201 atgtggttct tcctgcgagc ccgagccttg aaaaagaagg aacgtttaca aacacagaac 1234261 gccggattca gcgtttgtat caggtatttg aaccgctggg tgaatcaaag ccggattggc 1234321 agattattat ggaggttgcc aataagcttg gcgccggctg gctctatgag catcctgcag 1234381 acattatgga ggaagcagcc aagctgtcgc cgatttatgc cggtgtcacc tatgaacgtc 1234441 ttgagggcta taattccctg caatggcctg taaacgctga tggaaaggat tcgcctttac 1234501 tctttacaga gcgcttccct ttcccagacg gcaaggccat tctctaccct gtccagtgga 1234561 cagagcctaa ggaattcggt gaggaatatg atatccatgt caacaatggg cggctcttgg 1234621 agcacttcca cgaagggaac ctgacttaca aatcaaaagg gatttcggag aaaacaccgg 1234681 aagtgttctt agaaatttct cctgagcttg cggcagaacg agggattcag gacggaaccc 1234741 tcgtcagact cacatcgcct ttcggaaatg tcaaagtgaa gtgcctgatt actgatcgag 1234801 tcaaagggaa ggaagtatat ctgccaatga acgattcagg ggaagcggcg atcaacctgt 1234861 taacaggcag ccatgccgat aaggataccg atacgcctgc ttacaaagaa acatcggcca 1234921 agatggaaat tttgaagcac gacggaatca gcccgctgcc taagatcaac caccgcaacg 1234981 gcaatccgca gccgcaaatc ggtgtgcagg ttcataagaa atgggcgcgg aaggattata 1235041 ttttccctgg tgacgctgtg aaaaggggga tgggccataa tggctaaagc gattaaacga 1235101 atccaaaaaa tcgaggtaac agaagaggat cagcgaaagc gtgatttgcg ggaaattgaa 1235161 gatgctctaa ttgaccacaa agaagcgatt ctcgaaacat tgcatatgct gggccatatg 1235221 aacgagcgcg gggtcctgcc gttgctccgc ggcctttttg gtcaagggga taaagttctt 1235281 gatatcctgg tgaaaaaggc agatacagag gaaacagcca atacgctgaa aaatctgctt 1235341 cttctgtttg gaacactcgg catgctggac gtgaagcagc tggagcctct cattttgaaa 1235401 gtgaatgcgg gtgtggcaag cgctgtagag cagaaaaaca gtgaagaaaa gacaggttat 1235461 tttgatatta tccgctcgct aaaagacccg gaaatcaaca aatcaattac actgctcttt 1235521 tcctttttaa aaggaatggg acaagataca aaggagctgg aacgcacgac gcagcctccg 1235581 gaacaccaaa aacatcatca ggaaccccga gagaaaagag gaatgaataa gcgagattga 1235641 cctcccaccc gagcggcttc agccagctcg ggttttttga tgaaaaggtc taatggacta 1235701 gtaaaaaata ttcaaatact aggaagaagt aagattgtga tgaatgagat agaaataatc 1235761 gttactttct tacctgttaa gaaaagggaa aatctgatta taatagaaat cgattacttt 1235821 agatggggga acaatcatga aaaaagtctt attactatta tttgtcttga cgatcgggtt 1235881 agcgctttct gcgtgcagcc aatcgagcga tgcgtcagag aaggaaaaac cgaaagagaa 1235941 aaaatcgcaa gaagagcttg aaaaggaact tgataaggaa ttgaaaaaag gcggtgagcc 1236001 gaagaccaaa aaagatgatc aaatacataa aataggagaa acatttaaag caggacatac 1236061 gaattttaca gtgaataaag ttgatagagt gcaaaaaggt gaatatatga atgttggcgg 1236121 agctgtaaat gaggagacaa aaacaataaa agatgatgag gaacggctta ttatagaagt 1236181 tacgatggaa aatatagggg aagattcaat aagctacaat tttatcgggt ttgatttaag 1236241 agataagaat gatcaatcag tgcggcctgt tttttctata gaagagaagg gcagaatcct 1236301 tatgggagga acactagtat cggggaaaaa ggttacaggt gtactcagtt atgtcatccc 1236361 taaaggagaa cagaaacatt acacactggt atataatccg tttttagctg atacaaatag 1236421 cagtaataca gaagagagag taaaggacga tattgattac ttggtgaagt tagattagat 1236481 gctaatttac agttgcacgt ttttcatctg tggaaaacgt gcatttttta tagcgaaact 1236541 tgacttgaaa ggatgagtga taaaagtgca aaccaaatgg ctggaacggg cacagcggat 1236601 tcgggcgatc gcccaagcgg ggcttgcttt ttccaaggat gtgtacgaca gggagaggta 1236661 cgaagagcta atgaagctta gcgcggaaat gatggcggat tactcggaga aggacattga 1236721 agttatcact gatttatggc aaggcgagaa gggctatcca acaccgaaag cggatgttcg 1236781 cggcgctgta ttcagagaga atcagatttt gcttgtccgg gagaagcatg atgagctgtg 1236841 gtcgctgccg ggcggatttt gcgagattgg tttatcgccg gctgaaaacg ttgtcaagga 1236901 aatcaaagaa gagtcggggt acgatacaga gccgtctcga ttgctggccg tgctagacag 1236961 ccataaacac tctcatcccc ctcagcctta tcactattat aaaatcttca tcgcatgcag 1237021 catgacggac gggcaggggg aaacagggat cgagacgaat catgccgctt tttttccgga 1237081 agacagactc ccgccgcttt ctcctaaacg aaacacaccc tcacagctta gcatgctgtt 1237141 tgactttttg cgccatccgg acaagaaaac gatatttgac taaaaaagaa agagcctgtg 1237201 ggctctttct tttttataat gtaatgtgtt tttcgttggc gagtttcaga agggtcaaaa 1237261 tagaatcggc ttgtttatgg ccgagttttt gctttaattt gttttcttca actaatcggc 1237321 tgccataaat tttgacggag gctttgtcga cgacagtatg ccagttttcc tgtttttttc 1237381 cctcaacaag cggtttttca tgtctctcag aaaaagagaa cacaaagagt acgaatgcaa 1237441 gtgaaagtag gattccgaca acttgttttt tgtaatcagt ctgtgctgcc acgttgttct 1237501 ctccttcacc ttttaccttc tatttaatca tagaaccaaa ttattttaca taatgggaaa 1237561 gtcatttttg gagttagtgc atttggttga aaacagagac gttttttgag cggagcggtg 1237621 caattgaatc catattggat ttgcgtgctt atgcctaagg tcacgttgtg agccaaaaca 1237681 gcagtgcaga atagaaaaaa attgaaagat tatggtaaga tgaacgaaat tcgaggggga 1237741 atatatgatg cctgcatcga acatcgtgat cgcctgcctg ctgttatcaa tttaattatt 1237801 tgtggtagtc cctctctttt tcgaaagcgg gaggtgaagt ggaacattaa ttgctgaatt 1237861 ctttcaaggg gagtgaccgt acatgaatgt gttaaaccgc cggcaagcct tgcagcgagc 1237921 gctgctcaat gggaaaaaca aacaggatgc gtatcatccg tttccatggt atgaatcgat 1237981 gagaaaggat gcgcctgttt cctttgatga agaaaaccaa gtgtggagcg tttttcttta 1238041 tgatgatgtc aaaaaagttg ttggggataa agagttgttt tccagttgca tgccgcagca 1238101 gacaagctct attggaaatt ccatcattaa catggacccg ccgaagcata caaaaatccg 1238161 ttcagtcgtg aacaaagcct ttactccgcg cgtgatgaag caatgggaac cgagaattca 1238221 agaaatcaca gatgaactga ttcaaaaatt tcaggggcgc agtgagtttg accttgttca 1238281 cgatttttca tacccgcttc cggttattgt gatatctgag ctgctgggag tgccttcagc 1238341 gcatatggaa cagtttaaag catggtctga tcttctggtc agtacaccga aggataaaag 1238401 tgaagaagct gaaaaagcct ttttggaaga acgagataag tgtgaggaag aactggccgc 1238461 gttttttgcc ggcatcatag aagaaaagcg aaacaaaccg gaacaggata ttatttctat 1238521 tttagtggaa gcggaagaaa caggcgagaa gctgtccggt gaagagctga ttccgttttg 1238581 cacgctgctg ctggtggccg gaaatgaaac cactacaaac ctgatttcaa atgcgatgta 1238641 cagcatatta gaaacgccag gcgtttacga ggaactgcgc agccatcctg aactgatgcc 1238701 tcaggcagtg gaggaagcct tgcgtttcag agcgccggcc ccggttttga ggcgcattgc 1238761 caagcgggat acggagatcg gggggcacct gattaaagaa ggtgatatgg ttttggcgtt 1238821 tgtggcatcg gcaaatcgtg atgaagcaaa gtttgacaga ccgcacatgt ttgatatccg 1238881 ccgccatccc aatccgcata ttgcgtttgg ccacggcatc catttttgcc ttggggcccc 1238941 gcttgcccgt cttgaagcaa atatcgcgtt aacgtctttg atttctgctt ttcctcatat 1239001 ggagtgcgtc agtatcactc cgattgaaaa cagtgtgata tacggattaa agagcttccg 1239061 tgtgaaaatg taatagataa ggagactgga gattcatgaa aaagtaccat atttcgatga 1239121 tcaatatccc ggcgtacgga catgtcaatc ctacgcttgc tttagtagag aagctttgtg 1239181 agaaagggca ccgtgtcacg tacgcgacga ctgaggagtt tgcgcccgct gttcagcaag 1239241 ccggtggaga agcattgatc tatcatacat ccttgaatat tgatcctaag caaatcaggg 1239301 agatgatgga aaagaatgac gcgcccctca gccttttgaa agaatcactc agcattctgc 1239361 cgcagcttga ggagttatat aaggatgatc agcctgatct gatcatctat gactttgttg 1239421 cgctggctgg taaattgttt gctgaaaagc ttaatgttcc ggtcattaag ctctgttcgt 1239481 catatgccca aaatgaatcc tttcagttag gaaatgaaga catgctgaaa aaaataagag 1239541 aagcagaggc tgaatttaaa gcctacttgg agcaagagaa gttgccggct gtttcatttg 1239601 aacagttagc tgtgccggaa gcattaaata ttgtctttat gccgaagtct tttcagattc 1239661 agcatgagac gttcgatgac cgtttctgtt ttgtcggccc ctctctcgga gaacggaagg 1239721 aaaaagaaag cctgttgatt gacaaggatg atcgcccgct tatgctgatt tctttgggta 1239781 cggcgtttaa cgcatggccg gaattttaca agatgtgcat caaggcattt cgggattctt 1239841 catggcaagt gatcatgtcg gttgggaaaa cgattgatcc agaaagcttg gaggatattc 1239901 ctgctaactt taccattcgc caaagtgtgc cgcagcttga ggtgttagag aaagctgatt 1239961 tgttcatctc tcatggcggg atgaacagta cgatggaagc gatgaacgca ggtgtgccgc 1240021 ttgtcgtcat tccgcaaatg tatgagcagg agctcactgc aaatcgggtt gatgaattag 1240081 gccttggcgt ttatttgccg aaagaggaag tgactgtttc cagcctgcag gaagcggttc 1240141 aggctgtatc cagtgatcaa gagctgctca gccgcgtcaa gaatatgcaa aaggatgtaa 1240201 aagaagctgg cggagcggag cgtgcggcag ctgagattga agcgtttatg aaaaaatccg 1240261 ctgtcccgca gtaaaaacat aaaaaccgaa atcaatttga tttcggtttt ctgtttaaat 1240321 attttttttc atcccgcatc tccggcattc tctaagaaat tttccgcctt ttacagagct 1240381 tttgaacagt gtgtaatcac agttgtcgca gcgcccgctg cgggcatccg gatattcatt 1240441 gaattcgtaa acaatcgatg tatcgtagcc ttttgtttca tattcttctt ttttggtttc 1240501 catgtcgatc ctccgttaca agacgtgtct gctgtttatc ttacagcaag cttccggcgt 1240561 attcaatgga ttttaggagg ttgggtttat cttgatttct cccttggttt gcgccaaaat 1240621 agctttatta agcttatata cataaaaagc ctatgcaaag aggagaggaa acgggtatgg 1240681 gaaaagggtt acttggaaaa cgcgtggcaa tcggtggctc acgaaaaacg gaagaaatta 1240741 gtacaatcat tgaaaaacag ggcggaatac ctgtcatccg gcctctccaa ggtacagttt 1240801 acttagcaga gaagcaggtg gagccggatt tgcggacgtt tgcggaagaa aaagctgact 1240861 gggtcatttt cacgacaggc atcgggttgg agactcttgt cgatatggca gagaaaattg 1240921 gactgaaaga tgagtttctg caggccattc gccaagcgaa agcggcatgc cggggataca 1240981 aaacgctgtc tgcgctgaaa aagcttggaa tcacaccgga agcttcggat gaagacggga 1241041 caacaagagg cttaatccgt tccttggagc ctcacgactt ttcaggaaaa acagtcatgg 1241101 tgcagcttca tggcgaaaaa gcgccggctc tcatggcatt tcttgaagaa aaaggcgcgt 1241161 ctgtcctgcc gattctgcct tatcagcaca tcccgccgga ggaggaaacg gtggagcggt 1241221 tatgccgaga gctgatgaac gatgaggtcg atgccgtttg ttttacaacg gccattcagg 1241281 ttcgttccct gtttgatttt gccaaggggc gaggttatat caatgaagtg aagaaggtat 1241341 tcgaagaacg cgccatcgca gctgctgtcg gaaaagtgac tgctgaagca ctgcgggaag 1241401 agggcattac gagactgctt gcgccagaga ttgagcggat gggtgcgatg attgttgagc 1241461 tggccaagta ttatgaagaa aaggaataac aagtacaaaa agccgctttt ccctcggaaa 1241521 gcggcttttg tctgtcattc attttgcttc agctgctgat gaacggtgaa taatgatggg 1241581 tatgtcagca cgcttaagat tacacaagtc agcgcggctg aggccatcgt tgtaaacacg 1241641 attaagagtt gaaagcgtac tgcctgaatc gggtccgcgc cggctagaat ctggccagtc 1241701 atcatgccgg gaagctggac aagacccagt gttttctggc tttcgagcgt cgggatcata 1241761 ctcattttca tcgctgaggt aagaatgcgc tgtatggatt gcttcggtgt gccgccaagt 1241821 gacaatatta attgaatttc ttctttgcga acgccgactt ctgagttaag ccggtttaga 1241881 aacaaacttg agagcaccat cgaatttccg atgaccatcc cgctgatcgg aatgacatat 1241941 cgtgccgtaa gcggaatgat atgaagagac agcagaattc cctgcgtcac aatttctacg 1242001 attgctaacg cggcaaacac cctccaaaac gaaccgatag tatttttctt tcgcttgatg 1242061 acattttgcg ccgccaccgc gagcattaac agcaccatca gcaggataaa aacagggtgg 1242121 tctccgcgaa aaatcagcga caaaacataa ccgatgataa gcagctgcac cgcggcccgg 1242181 atggtggcga tgatcatgtc tttttctaca ccggctttaa aggattttga taaaaacaag 1242241 gcgatcaaaa caaagatcat cgttaaagag agagaaaggt aatccattac cgagtgcctc 1242301 ccttcaaaaa ttctttcgct gcttcatgct gcggagcgga gaaaaatgtg tcggtttcag 1242361 cgatttcaag cagccggcca tctgccataa accaaatggt atcggctatt cgttttgcct 1242421 gctccatatt atgagtgacc cacatgactg tccatttttt ctcttgatgc tgacgtttga 1242481 tcagttcttc aatctcaaga gcagagaccg ggtccaaggc cgatgtgatt tcgtccaaca 1242541 atagaatgga ggaaggattt gagagcgttc tggccagtga cagtctttgc cgctgcccgc 1242601 ccgataagtc tctggcgctt ctgtctaaca actctggcgg cagccctgca agcgaagcca 1242661 gcttttcagg agagtacagc tgggattgat gcagcctttg tacaagactt aaattgtcac 1242721 gcactgtccc gtcgagcacg ggagccgatt gaaacgcgag ggctgccgtt cgcctcagct 1242781 cattgacatt ccattctctg acttcctttc cgtatatgtt gacttcgccg ctgtcaggcg 1242841 ttctcattaa attacacata gaaaggaggg tgcttttgcc tgagccggaa gggcctaaaa 1242901 cggctacgat tgcaccctgt tgaatgtctc cggtgacatc ctgcagcaca tcataggttt 1242961 gtccatcttg tttatagctt tttctgactg atctgaagga gatggctggt atgttttgtg 1243021 tttgatcgtt tgcttccatt acaataatca cctttcaata taagtaggct gacattatat 1243081 ttaactataa cgtgaaacag attccttttg gtagcacaaa taaaggagaa caggctttca 1243141 cccattctcc tgcagatgct acgcagtcag atttgactgt gctttctttt tcggttttct 1243201 cggctgtgaa gcgaaggtat gtaacatcat ccccgctatt ataatgaaca aaccggcaaa 1243261 tgataataga gatgggaaaa cgcctgacag cagaacaatt tcaccaagca gcgcgaaaat 1243321 cacttcaccg gattgagtgg cttcaacagc tgcgagtttt tgcggattgt ctcttaccat 1243381 atcagtggcc cagaaaaata aaaccgtcgc aatgatgcct gagctgacgg caacgataaa 1243441 ggattgaacg gtttgacttg ctgttggaag gccatctgac caccagccgt aagctgctaa 1243501 tataagccag aatggaaggc ttgccaatgt cattccaagc acgcgctgaa atgtatcaag 1243561 ccggcctccg tattcttcga gcattcttcg gtttcctaac ggataggcaa aagccgcaat 1243621 gacaaccggc agcacactga aaagcagcat cctcccagaa agcgattctg catgctgaag 1243681 ctgaatcaga gccgctccaa tcaggatgat cacagaagtg ccaagtgaaa ccaggggaat 1243741 cttttggcga atgagctgcg gaccgcccgg catatcttgt ttgacataaa acaaaggaga 1243801 taagagcacc ccggctacaa ttgtaatttg ccaggttcca gctatgagcc accccggacc 1243861 gtatgcagcc gcaaatgtaa tcggtgcgta aaaaagcacg aaaccgacga agctccattt 1243921 gatccaataa aacggctttt tcctcatttc tagtaagaga ggcgtgaatg tccctctcat 1243981 gatgacaatc aaacataaaa atggcaccat aaaaataaag cgcagcgaag agctccaaag 1244041 ccagctgcct cctgataact ccatcgctct gtttaatata aaggtaacgg cgaaaaagag 1244101 tgaagccaat attccgataa cgatagcttt catgatatcc ctcattctgg cattattttt 1244161 ttatactata ctattcggta tcatgcagat caatggaatc atgagaaaaa catcatgttt 1244221 ggcgaaccgc tatatgtgga agacaaaaaa gggaggtgaa attgatggaa agagagacac 1244281 agacatactt ctttccggat gacggcagga ttccgaatca ccctgatttt ccgctcgtgg 1244341 tgtatcaaaa cgcgcttaag gacaccggac tggcagagcg gatcgtcacc cggcatggct 1244401 ggtcaaacag ctggtcaggg agtgtttttc cataccatca ttatcacagc aatacgcatg 1244461 aagtcctgat tgcccttagg agagaggctg tgattcagtt tgggggagaa aaaggggctg 1244521 ccatcccttt caaatcaggc gacgcagtcg tgattccagc cggagtcgga cataaaaagc 1244581 tcagctcaag ccccgatttt actgtccttg gcgcctatcc cggtggcgtt cagtacgata 1244641 tgaagacggg gaagccgaat gagcgggagg aagcggtcaa acagattaag caggcggcgt 1244701 tgccggcgaa tgatccgatc acaggaaaaa gagagcctct attggaaata tgggtaaagt 1244761 gaaggggaga aattgctgga ttgtcaataa ctagtgccgc agaaacgata tgacatgagc 1244821 tccatataaa ttaatttcat aatcgaagca attcacgttc aaattttgtt caaaaagtgt 1244881 tatcatatag aaggtaatcg aattggagtt ttttgtgttt gctattttca gagagagtaa 1244941 aggattttga cttattcaat tgtttatttt tagataaaaa taatactgaa tatggcaaga 1245001 tgaaaaactg ggtagtaaac atttattttt gtaaatgatt gtgcatgaat tcacaatcct 1245061 tattcttatg ccttaaaagc gtgagacagg gagaggcact accctttcca aaaaaatcag 1245121 caaactgctt atagtaaagg agaattggat atgccagaaa caatcgatca aacaaatgcg 1245181 tctgtcagcc aaagccagca agatcttatt gatcagctat taaagccaga agttcaagaa 1245241 tcattgactg ttttagttga ccagcttccg aagctgactg agttagtgaa tattttaacg 1245301 aagtcttatg atttcgctca gtctgtagcg actgacgaag tgttaaagag cgacacagtc 1245361 ggtgcgatca ctgaaattct cgagcctgta aaagaaacag cgaaagaagt agctgcgact 1245421 gcgatcgaag caaaagaccg cgcggaagca agcaacgaaa caattggact tttcggcctt 1245481 cttcgcatgc tgaaagatcc tcaagctcaa aagctgttcc gttttgctaa cagctacctt 1245541 gaagtcatga acgaacgcga aaaccaaaaa taatctcaga ttcaaattga tataaaggac 1245601 ggaggatata cgatgtcaaa acatattgtc attctaggcg ctggttatgg cggagttctt 1245661 tctgctctaa cagttcgcaa acattacaca aaagaacaag cacgcgtgac agtggtaaac 1245721 aaatacccaa ctcaccaaat cattacggaa ttacaccgcc ttgctgcagg caacgtgtct 1245781 gaaaaagcgg ttgcaatgcc attagaaaaa cttttcaaag gcaaagacat tgatcttaaa 1245841 attgcggaag taagctcttt ctctgttgat aaaaaagaag ttgcgcttgc tgacggttct 1245901 acattaactt acgatgcgct tgttgtaggt cttggttctg taacggctta cttcggcatc 1245961 ccaggtcttg aagaaaacag catggtattg aaatctgctg ccgatgcgaa caaagtcttc 1246021 caacatgttg aagatcgtgt gcgcgagtac tctaaaacga aaaacgaagc agatgcaaca 1246081 atccttatcg gcggaggcgg cttaacaggt gttgagcttg ttggtgagct tgctgacatc 1246141 atgccgaacc ttgcgaaaaa atacggcgta gaccataaag aaatcaaatt gaaacttgtt 1246201 gaagcaggtc cgaagatcct tcctgttctt ccggatgatc ttatcgagcg tgcgactgca 1246261 agccttgaaa aacgcggcgt tgagttctta acaggtcttc ctgttacaaa tgtagaagga 1246321 aacgtaatcg atctgaaaga cggatctaaa gttgttgcca acacatttgt ttggactggc 1246381 ggcgtacaag gtaacccatt agtcggtgaa tcaggcctag aagtgaaccg cggacgcgcg 1246441 actgtaaatg acttcctgca atctacatct catgaagatg tattcgttgc tggagacagc 1246501 gcagtttact tcggtccaga cggccgtcca tacccgccaa ctgcacaaat cgcatggcaa 1246561 atgggtgagc tgatcggtta caacctattc gcttacctag aaggcaaaac gcttgaaaca 1246621 ttcaagccag taaactctgg tacacttgca agccttggac gcaaagacgc ggttgccatc 1246681 attggtgcta attctacacc gcttaaaggt cttcctgctt ccttgatgaa agaagcaagt 1246741 aatgtacgat atttgacaca tattaaagga cttttcagcc tggcttacta atccttttaa 1246801 tgaatctggc attgccaaaa gcattccttt ccgagtgctt tctggcaatg tcttttttta 1246861 tgtttatgac agcgttaaca tttcattttc aaaaaagaga ttgatcccaa aggaatataa 1246921 aggtaaaata aaaacaaatc aaaatgttaa cgttaacatt ttgaaataga atgaaagacg 1246981 gtgaggacat ggaacccttc atgggcaaaa actttttatt gaaaaatgaa accgctgtca 1247041 gcctctatca caattatgcg aaagacatgc caattattga ttaccactgc cacttaagtc 1247101 cgaaagaaat ctatgaaaat aagacatttc aaaacatcac ggaagcctgg ctgtatggtg 1247161 accattataa atggcgcatc atgagagcca atggaattga ggagacatac attaccggag 1247221 atgcgcctga tgaggagaaa tttatggctt gggcgaaaac cgtgccgatg gcgattggca 1247281 acccgctcta caactggact cacttagaat tgcagcgttt ttttggcatt tacgagattt 1247341 taaacgagaa gtccgggtcg gctatatgga aacagacaaa taaactgctc aaaggggaag 1247401 gcttcggggc aagggattta atcgtgaaat caaatgtaaa ggtcgtgtgc accacagatg 1247461 accctgttga ttctcttgaa taccatttat tgttaaaaga agacaaagac tttcctgtca 1247521 gtgtgctgcc tggatttcgg ccggataaag gacttgagat caatcgtgaa ggctttcctg 1247581 agtgggtgca ggcgcttgaa gatgccgctg ccatatcgat tacaacctat gatgagtttt 1247641 taaaggcgtt ggaaaaacga gtgcgattct tccactcagc cggcggcaga gtttctgatc 1247701 acgcgataga tacaatggta tttgccgaaa caacaaaaga agaagctgga cggatttttt 1247761 ctgacagatt acaaggaaca gaggtttctt gtgaagatga gaagaaattt aagacatata 1247821 cgcttcagtt tctttgcggt ttgtatgcgg agctcgattg ggcgatgcag tttcatatca 1247881 acgctttaag aaacacgaat acaaaaatga tgaaaaggct cggacctgat acagggtatg 1247941 attcaatgaa cgatgaagaa attgctaagc ctttatacaa gctgctgaac tcagttgaga 1248001 tgaagaacca gctgccgaaa acgattttat attcactgaa tccaaatgat aactatgtca 1248061 tcgccagcat gatcaacagt tttcaggacg gtattacccc gggaaaaata caattcggca 1248121 cagcctggtg gtttaacgat actaaagacg gaatgctcga ccaaatgaaa gcgttatcaa 1248181 atgttggcct tttcagccgt tttatcggca tgctcaccga ttccagaagc tttctttcgt 1248241 atacgcgcca cgaatatttc aggcggatcg tctgcaattt gattggagaa tgggtggaaa 1248301 acggcgaagt gccgcgcgat atggagcttc tgggaagcat cgttcagggg atttgctatg 1248361 acaatgcgaa acactacttt caatttcaag aagagaaagc aaacgtgtaa caaagtgtcc 1248421 gctcagtatc gctgagcgga tcactatccg aaaattctta agacacagag gtggaacatg 1248481 cgaactgaac tggcaaataa ggttgtgtcg gtcgaaacgg aaaaaaggct ttcattgaaa 1248541 gagaaaatgt cctatggctt tggtgatttt ggcaacggtt ttatgtttga tctcggccag 1248601 atttatttat tgaagtattt cactgatgta gcgggaatcc ccgctgcgat ggccggcggc 1248661 atttttttag tcagtaagct gtttgcagcg ataacagatc caattgtcgg ctcatcaatc 1248721 gattatcgca aaaacatcgg caaacggggg aaattcaggc cttatctatt aatcggcagc 1248781 atcgtgcttg cggtgcttac tgttcttatt tttctgtctc ccaatgtatc aacgaccgga 1248841 aaactgatat atgcatatgc atcctatatg atttggggca tcggctattc gtttgtgaat 1248901 attccgtacg gctcattagg ggcagcgatg actcaaaatt ctgaggaccg gacctccatt 1248961 tcgacgttcc gccaaatcgg atcacttggc gccttgttta tcacaagtgt ggccgtgatg 1249021 ccgctgctcg tcaagtttga taatccgaag gtcggctacc cggtggtcat gggcttgttc 1249081 gccgcgctcg gtgtgttttg gttttatatt tgctaccgca actgcaaaga gcgcattatc 1249141 atatcggaag cacccaaaga aaaattaaca ctctcatctg tcgtcaaaac atttattaca 1249201 aataaaccgc tgttaaccct tgtcctgatg acgatttttt caatttccgc atacaacatt 1249261 aaatccgcca tgctcgtcta tttcgcacaa tataacttgg gcaatgttga attaatggct 1249321 tatatgaact tcatcattat tggttcttcc tttttgggcg tcgtattcct tccaaagctc 1249381 gtcaagatgt ttggaaagaa acgaacggca atgatcggct ttggcatcag tgtggccgcg 1249441 gatctgatca actttatgct tccatctaac gtttatgtgt ttacaattct cgccagtatc 1249501 gcctttatcg gaatcagtat cccaaatggc atcacgtggg ctcttgtctc cgatattatc 1249561 gactatggcg aatggaaatc cggtgaacgg aaggaagcaa cgacatattc acttttcaat 1249621 ttctcaagaa agcttgctca atctttgtct ggctttctct cggggatcgg tttggggatt 1249681 atcggctatg tgccgaatgc agtccagaca gcacaggcgc tgattggcat caaagcgctg 1249741 cttcttctgt atccggccat tgctttggca ttagcgatgt tcattatcgg ctttctttat 1249801 aaactcacag accagcagca tgctcagatc gttcaggatc ttcatcaaaa gagctgacaa 1249861 tataatataa agaatattta aaataatttg taaataaaat gtgtttgtag gggtttcgct 1249921 tggagagtgc ccaaaaaact gaaaaggaag gaggcacttg cttgaaaacg ataacaattg 1249981 cagctgaaga agcaaaggaa ctcgtttggc aaaagctgga cggtgccggt ttgaatgaac 1250041 gagatgctga aaaagtggca gatgttctcg tgcacgctga tttgcgcaat gtacattcgc 1250101 atggcgtgct gcacacagaa cactatgtga acaggctttt agcgggaggg atcaatcctg 1250161 gggcacagcc tgtttttaaa gagacggggc ctgtgaccgg ggtgcttgac ggagacgatg 1250221 gtttcggtca tgtgaattgc gacatggcga tggaccatgc aattgacatg gcgaagaaaa 1250281 aaggagtcgg catggtcacg gccgtaaaca gcagccattg cggagcgcta agctattttg 1250341 tgcaaaaagc ggctgacgaa aagctgatcg gaatggcaat gacgcataca gacagtatcg 1250401 ttgtcccatt tggggggagg actcctattt tagggacaaa tccgattgct tacggagttc 1250461 cggctaagca taaaaaaccg tttatcctag atatggcgac atccaaagtg gcttttggga 1250521 agattctgca ggcccgtgaa gagggcaaag aaattcctga aggatgggga gtcgatgaaa 1250581 acggagaagc agtaactgat cctgacaagg tcgtctcact ttcaacattc gggggcccga 1250641 aaggctatgg actatcgatt gtagtggatg tgttttccgg attgctggcg ggcgcggctt 1250701 ttggccctca tattgccaaa atgtacaacg gccttgatca aaaaagaaag ctggggcatt 1250761 acgtttgcgc gatcaatcca tcctttttta ctgactggga tacgttttta gagcagatgg 1250821 atgccatgat tgatgaactg cagcaatcac cgccggctgt tggattcgaa agagtgtatg 1250881 tgcccggcga gatcgagcag ctgcatgaag aaagaaataa gaaaaacgga atttctatcg 1250941 cccggagcgt gtatgaattc ttaaaaagca ggtgagtaaa atgaaagcgg ttcaagtgcg 1251001 aaaagcgtat gatctggtga cagcggaggt gaagaagcca gttctttcaa aggatgatga 1251061 agtgctcgtg aaagtcaagc gagtcggcat ttgcggttca gacatgcaca tttatcatgg 1251121 aacgaatccg ctcgctaccc tcccgagagt catcggacac gaggtaacgg gacaagtgga 1251181 ggcagttggt gcgaatgtac agagcctaaa acccggtgat catgtggtga ttgagccgat 1251241 ttcttattgc ggatcgtgct atgcctgccg caaagggcgg ccgaatgttt gcgccaagct 1251301 ttctgtattt ggcgtacatg aggacggagg catgcgggaa tatattgtgc ttccggaaag 1251361 acagcttcac gcggtctcaa aggacttgcc ttgggaggaa gcagtcatgg ccgagcctta 1251421 tacgataggc gcccaggcag tgtggagagg ccaggtggaa aaaggtgata ccgtcctgat 1251481 ccagggagcg gggcccatcg ggatctgtgt gttaaaaatg gcaaaactgg cgggcgctgc 1251541 tgtcatgatg actgacttga acaacgagcg gctggcattt gcgaaagaaa acggcgccga 1251601 tgctgttgta aatgtccaag cagaacatgt tgccgagcgg gtccttgaat ggactgggaa 1251661 tgaaggagca aacgtggtca ttgatgctgt ttgcctgccg gagacttttg cactttcaat 1251721 tgaggctgtg tcaccggcgg gacatgtggt tgtgcttgga tttgatgaaa gagcggctca 1251781 gatttctcag ctgccaatta caaaaaaaga agtcacgata accggatccc gattgcagac 1251841 caatcagttt ccaaaagtgg tagagctttt gaatggaggc cggttaatgc ataacgggct 1251901 ggtgacccat acattttcag ttgatgacgt tcatcatgca tttcagttta ttaaggagca 1251961 tccagatcag gtgcggaaag ccgtcatcac gtttgattaa atgactgaat ccggaggtgc 1252021 gagcatgaat atgacattcc gatggtatgg acgaggcaac gatacagtca cacttgaata 1252081 cgtgaagcaa attcccggtg tcaaaggcat cgtttgggct ctccatcaaa agcccgtcgg 1252141 cgacgtgtgg gaaaaagaag aaatcagagc cgaaactgaa tatattcaat cctatggttt 1252201 tcatgctgaa gttgtagaaa gcgtgaatgt tcacgaagcg attaaacttg ggaacgaaga 1252261 acgcggccgg tatattgaaa actacaagca aacgatccgc aaccttgccg gatttggcgt 1252321 gaaagtgatc tgctataatt ttatgccggt ttttgattgg acacgcacgg acatgttccg 1252381 gccgctagaa gatggatcga ccgctctgtt ttttgaaaag gccaaggtgg aaagccttga 1252441 tcctcaagag ctgattcgga cggtggagga agcatccgac atgacactgc cggggtggga 1252501 gcccgaaaaa ttggctcgga tcaaagagct ttttgctgcc tacagaacgg tcgatgaaga 1252561 aaagctatgg gacaatttat cattcttttt gcaggaaatt cttcctgttg ctgaggccta 1252621 tggtgttcaa atggccattc atccggatga cccgccgtgg ccgattttcg gactgccgcg 1252681 cattatcaca ggagaggcaa gctataagaa actgcgggcg atatcagatt caccgtctaa 1252741 ttgtatcacc ctttgtacag gttcaatggg agccaatccc gctaacgaca tggtggagat 1252801 cgctaaaacg tatgccggca tcgctccatt ttcacatatt cgcaatgtga aaatttatga 1252861 gaatggcgat tttattgaaa catctcattt aacaaaggat ggttcgatca acattcaagg 1252921 cgtgatggaa gaactgcata agcaggatta cgaaggatat gtcagaccgg atcatgggcg 1252981 ccatctttgg ggcgagcaat gccgcccggg atatggctta tacgatcggg cacttggcat 1253041 catgtatttg aacgggctgt gggacgctta tgaagcaatg gcaaaaaaag aggtgggcat 1253101 atgatcccgc tgcatgagaa cctggctggt aaaacggctg tcatcactgg cggcagcggc 1253161 gtgctttgct ctgcgatggc ccgggagcta gcccgtcatg gcatgaaggt ggcgattttg 1253221 aatcggacgg ctgaaaaagg ccaagcggtc gtgaaggaga taacggcggc tggcggcaca 1253281 gcgtgcgctg ttgctgcgga tgtgctggac aggatgtcac tggagcgggc aaaggaagac 1253341 atccttggcc aatttggcgc tgttgatctg ttaattaacg gggctggcgg caatcatcct 1253401 gacgcgataa ccgatgtgga gacatatgaa gaagcgggag aaggccaatc cttttttgat 1253461 atggatgaga ggggctttct aactgtattc tccaccaact tcaccggtgc gtttctggcc 1253521 tcgcaagtgt ttggtaaaga actgctgaag gcggattcac ccgcgatcat caacctttct 1253581 tccatgagtg cttattcacc tatgacgaag gttccggcat acagtgctgc gaaagcatcc 1253641 atcaataatt ttacgatgtg gatggctgtt cattttgccg aaaccgggct gcgggtcaat 1253701 gcgattgccc caggcttctt tctgacaaaa caaaatcatg atctgctgat caaccaagac 1253761 ggaacgttca ccagccgatc tcacaaaatt attgcgggaa caccgatgaa gcgcttcgga 1253821 aaaccggagg atttgctcgg tacgctcctt tggctggcgg atgaatccta ttccggtttt 1253881 gtcactggga tcaccgttcc tgtcgatgga ggatttatgg cttattcagg tgtgtaacga 1253941 aagcggtgca acagaaactg aaccaacata ggggtgaggt tgagatgttt tcaaaagata 1254001 agcttcccgt tatccttttt ttgttcctgg caggggtgat taattacctg gatcgctcgg 1254061 cgctttccat tgcagctcct tttattcagg atgatctcac attgtctgcc acacaaatgg 1254121 gcttgatttt cagcagtttt tcgataggtt atgccatttt taattttctt gggggcgtgg 1254181 catccgaccg ctatggggca aagctgacct tgtttgtcgc gatggttgtt tggtcgctgt 1254241 ttagcggagc agtcgccctc gcttttggct ttgtcagcct gctgattata cgcattctct 1254301 tcggaatggg agaaggcccg ctttcggcga ccatcaacaa gatggtgaac aactggttcc 1254361 cgccgaccca gcgggcgtcc gttatcggtg taaccaacag cggcacgccc ctcgggggag 1254421 ccatttccgg cccgatagtc ggcatgatcg cagtggcgtt cagctggaag gtatccttcg 1254481 ttctcattat gattattgga ttgatatggg cagtgctctg gttcaagttt gtcaaagaaa 1254541 agccgcaaga gacgatcaag gaagcaccgg caataaaagc agaaacgtct cccggagaaa 1254601 aaattccgct caccttttac ctgaagcaaa aaacagtcct gttcacggcg ttcgcttttt 1254661 tcgcttacaa ctacatcctc ttcttctttt tgacatggtt tccgagctat cttgtcgacg 1254721 agcggggatt aagtgttgaa tcgatgagtg tcatcacggt cataccgtgg attttaggat 1254781 ttatcgggct ggctgcgggg ggatttgttt ctgactatgt gtacaaaaaa acggcccgaa 1254841 aaggtgtgct gttctcgcgc aaggttgtgc ttgtcacgtg tttgttttca tcagctgtcc 1254901 tgattggttt tgccgggctt gtggcaacga ctgcgggggc tgtcactctt gtcgctctgt 1254961 cagtgttctt tctttatttg accggtgcta tctattgggc tgtcattcaa gatgtggttg 1255021 atcaaaacaa tgtcggttct gttggcggct tcatgcattt cctcgccaac acggcaggaa 1255081 ttatcggccc ggctttaacc ggatttattg ttgaccaaac aggcacgttt tctggagcat 1255141 ttttgcttgc cggtgggctg gctgtcttcg cttcacttgc tgtgattcgt tttgtccgtc 1255201 caatcattgg taagccagcg ggaacagaag ctgagaatcc tgtgtcttat taatctggaa 1255261 atatagtggg agaggcggta tgtttgatga tacaatatac agtaaataat cgcagccggt 1255321 atgataagga agggaattag atggtaacca taaaagatat cgcaaaactc gcaaacgtat 1255381 cccacactac tgtttccaga gcactcaaca acagccctta catcaaagaa catacgaaga 1255441 aaaaaatatt agagctagca gagcagctca actatacacc aaatgtaaat gcgaaaagtc 1255501 tggcgatgca aaagtcgcat acgatcgggc tattctttac aagcattaca aacggaacct 1255561 cacacagctt ctttgcagac actatcaaag gcgtcaatca agccataagt gaggattaca 1255621 atctgtatgt gcgcggcatt gatgatctga aaaactatga ctccgttaca ccgatgagat 1255681 atgacggcat cattttaatg agccaaagtg acattgataa ttcttttatt taccatattc 1255741 gcgaaaaaaa cattccgctt gtcgtgctga atcgtgatat tgatgatcgt accatcacga 1255801 atattttgtc caatgacaag gaaggctctc aagaagctgt agaatacttc attcagtccg 1255861 gacatcaaga catcgccatc atcgagggga tcgaaggctt taaatcctcc cagcagcgaa 1255921 aggaagggta cttatccgca ctgattcaac atcatattcc gatcaagcat gaatacagtg 1255981 tcaaaggaca gtacgatatg gaaagcggct ttcaagcgat ggagcggctg ctggcactgc 1256041 cgaatcctcc aaccgctgtt ttttgttcga atgatgacat ggcaatcgga gcgatgaatg 1256101 cgatattcgc aaagggcctg cgcgttcctg atgatatttc ggtgatcggg tttgatgata 1256161 ttgggttttc acagtacatc acgccaaggc tttcaacagt aaagcgccca gtggagaaaa 1256221 taagcgtgct cggtgcgcaa aaactcttgt cgctgatcag cgagcccgaa acaaaagcag 1256281 aaaaaatctt ggaaaacaca gaatttatgg tgcgtgattc agtcagacga ttgacgacgt 1256341 gatgtcccgt ttttcagcgg gcattcttta tacagaaaaa tgttaacgtg tgcataaagt 1256401 gagagggagg caataagggt gcagaagctg aataaaaatg tgtacgatca ctatactcag 1256461 tatccagaaa aaattctcca attcggagaa ggaaactttc ttcggggatt tatcgattgg 1256521 cagattgatc aattgaatca acacactgat tttaatggga gcgtggcagt tgtccagcca 1256581 agaggctcag aaaaaatcaa acgattaaat gagcaagatg gattatatac acttttttta 1256641 caaggaatga aagacggaga agcggtaaac gagcatatga ttatcaactc aatcagccgg 1256701 ggaattgacc tgttttctga ttatgaagca tacaaagaat tggcatcaag cgaaaggctt 1256761 cggtttatta tctccaacac cactgaggct gggattgtat gtgatgaaaa agatcgttta 1256821 gaggataggc cgcaaaaaac attccctggg aaattaactg catttcttta ctttcgctat 1256881 caggctttta aaggagatca gacaaaaggg tgtgtcctga tcccatgtga actgatcgag 1256941 aataacggtg aaaagctgag ggaaacggtt cttcattatg cacatctgtg gaagctggag 1257001 gaaggattta cacagtggat tcatgaggcc aatacatttt gtaatagttt agtagaccgg 1257061 attgttccgg gttttcccgt cgacagcatt gatgagatca cggcagatct tggctatcag 1257121 gatgatttga tagttgtggg agagcaatat tatttgtggg ttatcgaggg gcctgattgg 1257181 attggaaaag aacttccctt tgcggctgca gggctgcata caaagatcgt cagcgacctc 1257241 accccatacc ggactaaaaa agtaagaatt ttaaatggcg ctcatacagc aatgacgcca 1257301 gtggctttat tatacggctt gaagactgtt agggatgcag tcgagcatcc ggaagtgggg 1257361 cgatttataa gagagctgat tgatgacgaa attcttcctg ttttaaaaat ggaaggtctt 1257421 tctcagtatg ctgacgatgt gctgaaccgt tttaaaaacc cgtatattaa gcattacctg 1257481 gaaagcattg cattgaacgc catttccaaa ttcaaaacga gaaacctgcc gactcttaag 1257541 gaatatgctg aacaaaaggg acagcttcct gaacgcttgg tgttttcttt cagcgctctt 1257601 ctgtattttt atcatgataa cgagacattg caggatgatc cggcagttct tcaatttttc 1257661 aaagaggttt ggtgtcagga ggatggcgac atgcttcgga ttgcatcaag agtgttaggc 1257721 gaacagcggc tgtggggggc agatctcaat gagataccga agctgactga tagagtcgct 1257781 gtttacttga atcatattca tgagctgggc atgcagaggg ctcttgaaca atactgcata 1257841 caagggggag aggtacgttg aagtcgttta taaagattca taagcaagat aatgtccttc 1257901 ttgctctgcg ggatattcaa aagggagaga ggctgcatgc ttacggcgtg tcgattgaag 1257961 taaaggatga tataaaaaga ggccataaga ttgcattgca gtctatcaaa gaaaacgaca 1258021 gcatcgtcaa gtacgggttt ccaatcggtc atgcatcaca agatatctcg atcggagagc 1258081 atattcatgt ccataatacg aaaacaaacc tgtctgatat ccaattatac agctatacac 1258141 cgagatttga tgaaaatccg tattctaatg agaaccggac gtttaaaggt tttagaagag 1258201 aaaacggaga tgcgggtgta cggaatgaat tgtggattgt cccaactgtc ggctgtgtca 1258261 atggaatagc agaaaaaatg ctgcagcgtt ttgtcagaga aacaggggat atcgctccat 1258321 ttgataacgt actggtgtta aagcatcaat acggatgctc gcagcttggc gacgatcatg 1258381 aaaatacgaa gcagatcctg ctgaatgcca ttcgccatcc aaatgccggc ggcgtcttgg 1258441 tgttagggct tggctgtgaa aacaatgagc tggcaagaat gaaggaagca ctgcaagatg 1258501 tgaacttgaa gcgggtgaag tttctggaat cccagtcggt gaccgacgaa atggaggcag 1258561 gcgttgcttt gctgaaggaa attcatgaag cggccaaagg agataagaga gaagacattc 1258621 cgctgtctga actgaagatc gggctgaaat gcggaggttc ggacggtttt tccggcataa 1258681 ccgcaaaccc gctgcttgga cgtttttcag attatctcat tgcacaggga gggagtactg 1258741 tgctgacgga agtaccggaa atgttcggcg cagaaaccat cctgatgcag cgggctgcca 1258801 atgaagaagt gtttcataag atagtcgatt taatcaatga tttcaaacaa tactttatta 1258861 aacatgatca gccggtgtac gaaaatcctt caccgggcaa caaagcgggc ggcatttcta 1258921 cacttgagga taaatcgctg ggctgtacgc aaaaagcggg gatttctcct gtcacggatg 1258981 tcttgaaata cggtgaagta ctcaagacaa aagggctgac tcttttgagc gcaccgggca 1259041 atgatttgat cgcctcctcc gcattggcgg ctgccggctg ccaaattgtc ctctttacaa 1259101 cgggaagagg cacgccgttt ggcacctttg tcccgacggt gaaagtagcg acaaacaccg 1259161 agctgtatga ggcgaagccg cattggattg attttaacgc aggcctttta gcagaggatg 1259221 atgttcatga ggaatatgtg ctgcgtgagt ttatccacta tatgattgag gtggcaagcg 1259281 gccagcttgt gaaccatgaa aaaaatgatt tcaaagaact cgccattttt aaatcgggtg 1259341 tgacgttata ataagaaaag gctatccttc aagcggatag ccttcttcat taaatcaatt 1259401 ttaaaccgct gactaaaata atggaagcca taataaattg cagtggacgc ggggagaatc 1259461 gaggcgaaag atggctcccg atcagtacgc cgggaattga accgaggagc agattagctg 1259521 ccagcatgta atccacgctt ccgaagcttg cgttcaaaat gcctgctgcc gtaacaagaa 1259581 gaaaagcatg cgcgatatcg gttccgacaa tctgtgacgc tttcatgtta aataagtaaa 1259641 tcatggcgat tgcaaataat gagccggacc cgattgatgt taatccgacg ataaacccaa 1259701 acacaacacc aataagaatt gtcagcgccc tcttattttc aagcggcatc agctgccagc 1259761 ggttggggcg aagttttcta tccaaaaaca aacgaacgat gattgaaatg gcaaccagcg 1259821 ttaacacata tcctagagcg tgcttaataa tttcttcctg atgctggtga aaggcgggga 1259881 acaaatgcaa tatgccaatg gctagcgaag cactcggaat accgccgatg gctaagtatt 1259941 ttaccaattt aaagttaatc gttttctgcc gccaatggga ggcaacgcca aacagctttg 1260001 tgatcgagtt atatacaaga tccgtaccga ccgcgatgga aggattaatt ccaagcacaa 1260061 ttaaaagggg agttaataag gccgctccac ccactcccgt caatccgact aaggctccga 1260121 caaacaaacc catcaatatg atgcttacac tcatgataaa ggcctcctga aaacccgact 1260181 agaattcacc cgaatcttat tcgcgttggt caagtattaa ttgtaagtgc tccatcggct 1260241 gctgaaaaac ccgagctcta tccgctccct gatggtatca ttcaattgac aacaccttat 1260301 acatcaggag aacacgtctt tcaggtgcaa cgagcacttg cggctctgta tttttaccct 1260361 gataaaggcg ctgttaacaa cggaattgac ggcgtttacg gaccgaaaac agctgacgca 1260421 gttgcccgtt ttcagtctgt taacggtcta actgctgacg gtatctacgg gcctgcgacg 1260481 aaagagaaga tcgcagcgca attaagctga tcaaagacca taaaaatccc ggagccgctc 1260541 cgggatttat tttttcttct tcaacttttt tataattcca gcactgcgct ccctcacccg 1260601 aagcgagtac ccggaaagcc caaaccttcc gtaatcaaca aacttcacac gcctcaccaa 1260661 ttttttcact gtatcacctg acattatcct ctgtttgtat ttattatatg tcacccttta 1260721 agaaaaggaa taaggacaag agctgttttc ccttgtcctt ttagtgtgat catgcttttt 1260781 ttcgtttata ctcgtcaatc agccgttcgt tttctttgaa gattcttgct gtatgcggac 1260841 tgacttgata gcttgcgaca ctggtggttg aacgtttttt caggatttta aacggcttcg 1260901 ccgctctggg ctcgcatctg ttttgaaacg cacgttccat tatccttcac cttcctcctc 1260961 aattggcagc accaaatcat atatgctcgt taatgacgta aatagcaaat aatcaaattc 1261021 cgtgacaatg ctgtcagacg tcagcttgat gacatagttc tgtgtctcga tggtaaaagg 1261081 gatgagaacc acttttccgt attggtcgta ataaacatcc tttcgatcga gccgtgtttg 1261141 tacatctgcc ggatcatcca tatgctcggt taaccggtct ttatcagcct gtgtcgaata 1261201 gtggcaaaga gaagccgtta agttcatttt atcagcatag gttttcagca gcttatcaat 1261261 accttcagca taagcatcta tacttccata ataaacatgg atcggttcgt ttttcaatag 1261321 gtattggtat gttttcagcc gattgagata catgtggagc atttcgttgt tttcttcaag 1261381 aatttctctt gtgtctgttt caagctcgct gccggccagt tttttgacat atgcacttaa 1261441 gaagataaaa gcatcaatca aagcaaaact gactgcgaca atgagatacc gttcccagtg 1261501 ggtaaatagg gaagtgggct catatgtcca gtataccata gcgcccagaa caaacagcaa 1261561 ataccaagtt ttccgaatgg cggacatttt ttctttgacc ttcgcttcga aacgccacgt 1261621 ggcatacacg tataacccca gtccggccac gatgcaccag accatgatct gaaagaataa 1261681 aaccatattc gaatccctca catctgaaat aggttctgct tattgtattc gagagatccg 1261741 gatggttttc ctgttccatc aaaaaaaccg ctcctttgac agaagcggtg tgacattaaa 1261801 atatcatatt taaaataaag taggcgatgg caccaagtgt cgctgaaatc ggaagcgtga 1261861 tgacccatgt aatgagcatt cgcttggccg taccccagtt tacgcctttt acgcggtggg 1261921 acgcaccgac gccaagaatt gatgaagaaa tgacgtgggt tgtactgacc ggcaaatgaa 1261981 taaacgtggc gccgaaaata atggctgctc cggttaagtc agcggaaaca ccgtttaccg 1262041 gacggatttt catgatcttt ccgccaacgg ttttgatgat tttccagccg ccgattgatg 1262101 ttccgagacc catggctgtc gcgcaggcga attgcaccca ggtaggaata tcattagcag 1262161 aagtatgtaa attcgctgtg atgagagcca ttgtgataat tcccattgct ttttgcgcat 1262221 cgtttgttcc gtgtgtatac gattgcaggg cagctgttac aatctgcact ctgcggaatt 1262281 gcttattcgt tttcgccaag ttgctgtctt tgaaaatcag cttaacgatg ctataaagaa 1262341 taaaaccaag gacaaaggca ataattggtg atagaatcag tgcttcaatg attttaatga 1262401 agcccttata gtttaacgct gcaaatccgg ctgccgcaat ggctgcaccg gcaatagcgc 1262461 cgatgatggc atgggatgag ctgcttggga taccgtagta ccatgtgata aggttccagg 1262521 caattgcagc gagtagcgca gccaaaatga caacagagcc attttccagc gtataaggat 1262581 ctacgatgtc tttcgtaatg gttttggcaa cacctgtaaa cgtcattgct ccgacaaagt 1262641 tcatcacagc agccaatata atggcatggc gcggttttaa cgcttttgtt gataccgaag 1262701 tcgcaattgc gtttgccgta tcatgaaacc cgttgatgaa atcaaacgcc agagcacaaa 1262761 tgactattag tatcgttaat attaatagaa tatccatttt tacccctcgt tacgcgtttt 1262821 tcataatgat ggtttcaaga ttattggcaa cactttgaca agagtcggcg atttcttcaa 1262881 gcgtttcgta tatttcacga tattgaatga ctttgattgg atctgtttca tttccgaaaa 1262941 gattctttaa tgattttctg tgcaagttgt cacaactgtg ctcatactct ttaattttga 1263001 ttgcgtgagg ctgaatatcc tttaagcgat tttctgccag cagctcgatc gtaatcaaaa 1263061 tctctttcgc acattctctg atatatccgc tgaatttatc aatatgctcg tctgatgaag 1263121 taattgagaa aatctccatc atggcagaga aatgttcgat tccgtcaagc acatcatcca 1263181 agctgtttgt cagctgaagg atatcttcgc gctcaatagg agtgatgaac gctttgttaa 1263241 gctctttaat catgacatga acatgattgt caccttttgt ttcatattcc tttaacgtat 1263301 ctgcaaattc tttaagagtc gtttggttag tgaccttaaa attcacaaaa tattctgcag 1263361 tttcgtctat gttctttgca atttctgtta aaaggagtga gaacttatct ttttttcttc 1263421 ttatcattaa aaaccctcca tagtttgaat gaacaatgca cacatcaaat tattatatag 1263481 ccttttgtcg aaaaaaaaca ggtaaagtcg aaaaaaacgt atcttgactt ttttgataaa 1263541 tcgtgtctcc ttattttgac ctacttcgct ttaaaaaaac gacccaagtt tgcaaaaact 1263601 ttctgcttaa cgtaaaaagt atatcaaaag ttgtgttttt cctgtcaact tttatcttct 1263661 gtttcaccaa aaaacggttc cctaaacaag ggaaccgttt tatcagcttg cttttcgttt 1263721 tttcatcccg taataaacag gcagtccggc aaggccgatg aggatggata atccgcagct 1263781 cattgtatct gtaatgagtg tgctgcctaa cacaaagaag gagcccgcga ttgccagaat 1263841 tggcataaat ggataaagcg gaacactgta ggcgcgcttt tctccctttg ctcgcttgcg 1263901 gagaataaac actgcaaaaa aggccatcac ataaaaaatg tagatcatga aaatggagat 1263961 ttctgagagc ttatcagggt tgctgatcag catcataatc aaagccaaag caatttgaaa 1264021 agaaatcgca atccatggtg tgcggaacga cgggtgtaca tgtgacagtt tttcagcaaa 1264081 tggaagctgt ttgcgttccg ccattgcaaa tgaaacacgc gggaaagaaa gcacctttcc 1264141 atttaagcac ccaaagatgc tgacgataat ccctacactg atcagctttc cgccaattga 1264201 accgaacagc atggttgcag cggtgcttgt cgcattttca ccaagcgtga caatttcgtt 1264261 cgctgacagg atgtgaagca atgcaaaatt aatgaaaata tagatcgccg ttacaattaa 1264321 taatccgccc gtcatagcgc gtggcagcag cttttcggga tttttcattt ctccgccgag 1264381 agcggcaagg agaatccatc cgtcataagc aaacaacgta gctaaaatag ccgccccgaa 1264441 gttcatatca gaaatgcttt cgtttactgc tgtgaagatg tgctgatcgc ctttccaaag 1264501 gccaaagacg atgatgcagg caatcggaat cagttttccg atcgttgtca gcgtttggac 1264561 aaaaccgccg tattttgtac cgataatatt aatgacgcat aaaaagagaa ctgctataat 1264621 tccaatgact tttgatagtc cagatcccca gccgaaaaga ttcgccatta aagatccaaa 1264681 atataaaccc agcgcgccaa taatcgccgg gccgtaaatg ataatctgca cccagccgca 1264741 caaaaatccc caaaactcgc cgtacacttc ttcaaggtac gtataaagcc cgccggtttt 1264801 tggaatctgc gttccgattt ccgcgattgt caaaccgccc gccagtgtta aaataccgcc 1264861 taacagccag gcgaaaagcg ccatttttga atcacctgaa taagcaagca cagcgccggg 1264921 cttcataaaa acaccagaac cgataatggt tccgatgaca agagtaaggg caaacaagag 1264981 gcctatctct tttttcaaac cgttgtcttc agtatgcatg tccttaacct cctatgatgt 1265041 tgaagcttca tgttgaagaa tctatttttt catattgtaa accctatttt agaaaagtga 1265101 aataaaataa attttctgat tttcgaaatt tgctttgtgt acagcagata aaactgtaga 1265161 aatacctgtt ttaatggtct ataaacgaat aaaattcata atttttattt acaaagttcg 1265221 tgttttatgt attaggattt tagccggtac agaggggaga tgagaattca gaaaatgaac 1265281 gaaccttcgg tgaagctgat atgttgactt tctcatgcga ataaaatact ttgttattag 1265341 aacaataaat atacaattat gatatgatat ctcgaaatcg agataaaata acctggaggg 1265401 acagcatatg aaagttaacg gcattcacca cgtatcggca ttaacggccg acgcacaaaa 1265461 aaacttggat ttctataaga aagtattagg attaaagctc gtcaaaaaat ccgtcaatca 1265521 ggatgaaccg acaatgtacc atctgttcta cggagatgaa gtggcaaacc cgggaactga 1265581 gctgacgttt ttcgagattc cccgcattgc accgtttcat gcgggaacaa acagtatttc 1265641 ttctattgga ttgcgcgttc caggcacaga agccctgcat tactggaaag aacgttttga 1265701 agagcagcaa gtaacgcaca gcggcatctc caaaagagcc ggacgtgaca tattggcatt 1265761 tcaagatcat gaggggcagc gacttgtgct gactgctgat gaggaaggaa aaggatatgg 1265821 cctgcctgtt aaacagagcg gcattccgga agaattttcg tttcgcgggt tagggccggt 1265881 tgaactgact gtgccatatg ctgaaccaac tttacacgta ttgacgaata ttcttggatt 1265941 tacagaaatc agccgtgaac cagtcgaagg gcaaggaacc gccgttattc tggaatcagg 1266001 agaaggcggt gctgcaacgg aaatccattt aatagaaaga aacgatcttc cgcgagagcg 1266061 tcaaggcaaa gggagtgttc accacgtcgc atttcgggta agagatgaag aagaacttgc 1266121 cgggtggcac cggatcatca gccgcgaagg ctttagcaat tcaggcatag ttgagcgcta 1266181 ctatttcaag gcgctgtatt tcagagaacc gaacggcatt ttgttcgagt tatcaacaga 1266241 cggaccgggc tttatggtag atgaaaatct tgatgagctt ggccaaacga ttgctcttcc 1266301 gccatatcta gagcatcgaa gagcagaaat tgaagcaaaa ttgaaaccga tccaataaat 1266361 tgtgattctt ttgccttccg gcgccgccgg agggcttttt ttattaccat aattaatttt 1266421 gacctaaaca gcatgcctta ttagggagga aatatcagat gctgattggg agaaatggct 1266481 taaaaccctt tgcaaatatg ggtgattggt atggaatggc ctcggcaaaa atattgtctt 1266541 tgtttattaa tagtttattc atatttgctt gttacactat ttcaaagtta gacaaaaagg 1266601 agtgaaaaat aagtggaaaa gaaaaaacgc gagctggata tcgtcctcct cctcattttg 1266661 ctcgcatctg cattcttaaa tatctataac atttggaagg acgacacggt gaatccttat 1266721 tacaccgcgg cagttacaag tatgatgcaa agctttcata atttctttta tgcttcgttc 1266781 gatgctgccg gctttataac agtagataaa ccgcctgtta cataccaaat ccaaacgatc 1266841 agcgcactga tattcggtat gcacggctgg agcgtcatcc tgcctcaggc acttgctggt 1266901 gtaggttctg tccttcttat gtacttgctg ataaagccga catttggaaa aacggcggcg 1266961 cgtattgcct catttgttat ggcatgtacg ccgatagctg tagctgtagc acgtacaaac 1267021 aatgttgatg cattactggt atttttctta ttgcttgcta catggcttct ctttaaagcg 1267081 atcagaaaag gaaagctgat ctggctgtta gcagcatttt tcgttgttgg agtaggtttt 1267141 aatacaaaaa tgctgcaggc ttacatgatt ttaccggctt tcttattgtt ctatctgatt 1267201 gcggcaaacg ccacaatcaa gaaaaaaatc gtttcattgg taagtgcgtt agccgtatta 1267261 gcagccgttt cgttatcgtg gccgctcatt gttgacaata tccctgcaag caagcggcct 1267321 tatatcggaa gcagccaaac caactctgtt ttggaattgg ctttcggcta taacggaatc 1267381 cagcggctga caggccaaaa ttcaggcggc ggccagggtg cgccaaacaa agacgcttca 1267441 aaagaaatgt cttcttctga taacactcaa gcaccgccta atcagtcatc aagcaacagc 1267501 tcatcaagcg atggtaaatc ctcaaatggc aatatggcgg cgcctccatc caatggccaa 1267561 atgccaagcg gcggtcaagg aggccctcca agcggcggag atggcggcca aggcggaccc 1267621 ggcggagacg gagggaaagg cggtacagga accggttcga aaatgcaatc aggttcaggg 1267681 atgtttggaa cgggaacacc tggtccactg cggcttttcc aacaagagtt atctgatcaa 1267741 atcagctggc ttctgccatt tgcgatattt ggaatcgcag gcttactgat cgctggcgca 1267801 agagaaagaa gaagattatc tgtagagcag aaggaaacgg tgttctgggt tgcgtggctt 1267861 gtaccgattg ccggattctt cagtgtcgca gaatttttcc atcattatta tctcatcatg 1267921 ctggcaccgc cgattgcggc tcttgtcggt gcggggtggg tcgctcttgt tcatctgtac 1267981 cgcaatcaga caggctggaa agcatggctt ttgccgggag caattattgc gacaactgga 1268041 tttgaattgt ttattctcag aaactacaac gatcaaatcg gtgttggatg gagtatcggg 1268101 gtaggtgtta tcggcgtgtt gtcagcgatt gctttgctgc tgtttaaaca gcgccaaaaa 1268161 ccgttcagtt attatgtttc acttgcagct ctcctcgcat tgctggtgat gccgatgtat 1268221 tgggcaagta caccgcttct gtacggaggc aacagctcac tgcctgaaac aggccctcaa 1268281 ctcgcatcaa tgagcggaaa aggcatggga atgtctgatg cgactgtaaa tgaaaaactg 1268341 atcaaatatc tagaggagaa taactccgga gctgaatacc tattcgccac aaccgattcg 1268401 aacacagcgg caccatatat cattaaaacg aaaaaagctg tcatggctat tggtggatac 1268461 agcggttctg acccggcaat cacactgact caattcaaaa aacttgtaaa agaaggaaaa 1268521 gtgaaatact tcttggcttc tggaatggga agaggcggaa acaatgacat tgttgaatgg 1268581 gttgagaaaa atggaaaaga agtagcatca gaaaaatggc aatcaagttc tgatcaaaaa 1268641 acagaaaata ctgattcagc tgatacatca agcagcaagg cttcaggtga aaacggcaaa 1268701 atgggcggac ctggcggaat gaatcagtca gcaacattat acgaactaca tgctgatgaa 1268761 taggaggcaa aaacatgagc agacatattc aatattcaat tgttgtacct gtgtataatg 1268821 aagagcttgt cattcatgaa acctatcagc gcttaaaaga ggtcatggat caaacgaagg 1268881 aaaactacga gctgcttttt gtcaacgatg gcagcaaaga ccgcagtatt gagattttaa 1268941 gagagcacag cctgatcgat ccgagagtga aaattattga tttttcaagg aattttggac 1269001 atcagatcgc cattacggca ggtatggatt atgcacaggg gaatgcaatc gtcgtcattg 1269061 acgccgattt gcaggaccct cctgaactga ttttagaaat gattgaaaag tggaaggaag 1269121 gctatgaagt cgtgtacgcc gtacggacta aacgaaaagg ggaaaccttt ttcaaaaaac 1269181 aaaccgcggc tatgttttac cggcttctca gcggtatgac agatattgat atcccgattg 1269241 atacggggga ttttcgcctc atggacagaa aagtctgtga tgaaatgaag agattaaaag 1269301 aaaaaaatcc atttgtaaga gggctagtca gctgggtggg tttcaaacag acagcggtcg 1269361 agtatgtacg tgatgaaagg ctcgccggag aaacaaagta cccgctcaag aaaatgctga 1269421 agctgtcaat ggacggcatc acgacatttt cacataaacc gctgaagctg gcaagctatg 1269481 cggggatttt aatgtcaggt actggatttc tgtatatgtt tatcgtgctg tatctgaagc 1269541 tattcacaga cagcacgatt accggctggt catcacttat tgtgatccag ctcctgttca 1269601 gcggcattgt ccttctgatt ttgggcgtga ttggcgaata tatcggcaga atctacgatg 1269661 aagccaaaga caggccgctt tacatcgtcc aaaaatcgta tggaattgaa aataaaagac 1269721 tctatagaga ccagcatatg tcataacctc aaaccccctg tccgtaatgg acagggggtt 1269781 tttatgctct gagcacgatc taaagcaaaa gatgctgata gatatatgga aattgggtaa 1269841 agaagagatt gtgagcttgt actgcggttc agtcatgctg aaataaaaac agcaaaactt 1269901 aaagatttcg tcctcggctt tgctgcatgt cagctgttat attggggggc ttttaagaaa 1269961 cgcatgatta gagccgtacc agttatgttt aatagaatac tcgtacccaa tacaattccc 1270021 cacgtcaacg tcgattcaga gagaagaaag ctcagcaaaa gaaaagccaa tcctgcgcag 1270081 atcataccca gtcccacggt tttcatgttc atgcctccta gcaaacgatg tttctagcat 1270141 ctgatgtgaa tgatgtcaat ctgtatgata tacggatatc tcgtcagaaa gtttcataga 1270201 acaattaggt cttttatcta ataaaaagcc tcagaccgct tttacggcct gaggcattat 1270261 gtcttacgaa gttttctctt ctttttgatc cagtttaatt tttttcgtca tttctttgcc 1270321 gtttcggaga attttcactt caacggtatc accgatcttt gcgtctttat ataagatatt 1270381 gcgcaattca ctgcctgtat caatttcttt accttttagg ccgatgataa tatcctccgc 1270441 ttttaatccg gccttttcag caggagagcc tgaagcgacc tcacggatgt aaacgccttt 1270501 attcagctgg ctgccgaaca ggccgagtgt gccttcttgg taattttgcg gcacttgctc 1270561 tagatcaagc atgctgacac cgatatatgg acgttcaatt tgtcctttag acagcaattc 1270621 ttcagcaatc ggttttacgt cattgcttgg aatggcgaat ccgataccct caacatcatc 1270681 ctcactgatt ttcatactgt taatgccgac aattttgccg tctgtattta acaaaggacc 1270741 gccgctgtta cctggattaa ttgctgcgtc tgtctgaatg acgttaatgc tcgtttcgcc 1270801 ggctgatgta gacattgaaa ccgttctgtc cacgccgctt acaattcctt gtgttactgt 1270861 gcgggacagg tcttttccaa gcggatcccc aatcgcaata acggtctcgc ctgttctaag 1270921 atcagatgaa tcaccgaagt ttgccacttt tgtgacgtgg tcatcactga tttggaggac 1270981 ggctaaatca gttaacgagt cactgcctac cagctttgca gtaacctcag tgccgtcata 1271041 taaagatacc ttcagtgatg atgccccttc tacgacgtgg ttatttgtaa tgatataagc 1271101 cttgccattc tcttttttga aaatgacacc tgaccctgaa ccgctttctg tatcttcgct 1271161 ggaatcagaa gaactagagc cgaacaaaga gctgtttgat tgtgcctgaa gatttgtaat 1271221 accgacaatc gctggtgaaa ggtcttctac catatctgag attttagaag agtcctcgct 1271281 cttgaatgca gatgagctgc ttgagctttt tttagattca gaggaggtgc ttgttgctgt 1271341 aacagattgc gtttgctgct ggctggatga ttgttttgca gtgtcctgag aatcatggtc 1271401 accaagcggt gtaaacgtgt aaatgccaag agcaagactg ccgccgatca ctccgccaag 1271461 caacggtctg aaccatccga atcctcgttt tttcttctcc tgatcatgaa tgacattgcg 1271521 ggccgagtag gaggcgctct gatcgttctc tttcgttaaa aagacctcat tctcattacc 1271581 tttcgttctg ttttcatcac gatagttatc catcatgttc actccgtttc tctattttca 1271641 catgtctatt tatattgata ggtttatgac ttgagtttat cataaacaaa aactgtggga 1271701 taaaaatgaa aagattatgg gaaattgtga aaaagtgcgg aaaacggtac acttcatatt 1271761 gtatatgaaa ggactgagtc gatggaacag attggattga ttggatatgg cagcatggcg 1271821 gatatgatcg ctagacagct gttgaaacat gaacaaataa aagagaatga gctatttatt 1271881 gagacgagaa cgaaggggga gcggctgcgg gcactcatgt cagattatcc aaacgtatcg 1271941 gctgatccgt tggagaattg ggcaaatacg tgccaattga ttttgatatg cgtcccgcca 1272001 ctccatgtca tcgaaacaat gcgccgtctg tacccgtatg tgaacagaaa tactcacatc 1272061 gtatccatag ctgccggtgt gccgctgcgt cttttggagg cagaaacaga agccggtatc 1272121 tcacgtgtta ttcctgccat tacgtccgaa gcagaagccg gcatctcact tgtcgttcac 1272181 agtgaagcac tggctgcaga gaaaaaagaa cgtctgaatg aattgttatc ggttttcagc 1272241 cgtgtacggg aaatcaaaga atcgaattta gatgtggcca gcaatttaac gagctcggca 1272301 ccgggattca tagctgcaat ctttgaagaa ctggcactgt ctgccgtcag aaacagcagc 1272361 ctgtccaaag aagaagcctt tgattttctg attcattcgc tatacggaac tggcaagatg 1272421 ctgatcgaaa aaaatatgtc tttcgaggag acgctggaac gtgttgcaac caaaggcgga 1272481 ataacgggag agggagctga ggtgatacac gcctctgtgc cggacgtttt tgatgaggta 1272541 tttgaaagaa ccctgagaaa atatgaactg cttacagaac aggttggtaa acaaacatga 1272601 atccttgaaa gaggattctt tttttatcac tgaatgattg agatttttcc cagttatatt 1272661 gcatttttcc tcttttttta atataatttg ttagaatatt cataatttag taaaaaagga 1272721 ggagcgttat gaaattgtac atgtcagtag atatggaagg tatttcgggt cttccggacg 1272781 atacctttgt ggattccggc aagcggaatt atgaacgcgg acggcttatc atgactgaag 1272841 aagcaaacta ctgtattgct gaagcgttta acagcgggtg taccgaggtg ctggtcaatg 1272901 acagtcattc gaagatgaat aatctgatgg ttgaaaagct tcaccctgaa gcagacttga 1272961 tttctggtga cgtcaaacca ttttcaatgg tggagggact ggatgatacg tttagaggcg 1273021 ctttgtttct cggttatcat gcgagagcct cgactcctgg tgtcatgtca cacagcatga 1273081 ttttcggcgt ccgtcatttt tacataaacg atcggcctgt cggtgagctt ggattaaatg 1273141 catacgttgc cggttattat gatgtcccgg tattaatggt agccggggat gaccgggcgg 1273201 cgaaggaagc agaagagctt atcccgaacg tgacgacagc cgcagtcaaa caaaccattt 1273261 caagatccgc agtgaagtgc ttgtcgcctg cgaaagccgg acggctgttg acagaaaaaa 1273321 ccgcatttgc cctgcaaaac aaggacaaag tcaagccgct cacaccgcct gacaggccag 1273381 ttctgagcat tgaattcgcc aattatggcc aagcagaatg ggcgaatctg atgccgggaa 1273441 cggaaatcaa gacgggaact acaaccgttc aatttcaggc gaaggacatg cttgaagcct 1273501 atcaggcgat gcttgtcatg actgagcttg cgatgcggac atcattctgc taaaggggtg 1273561 ttttaggctt tggcgcgata catgataaag cgtttttggg caatggcagc tacgattttg 1273621 gtgattacca ccctgacttt tgttctcatg aaggtcattc ccggatctcc ttttaacgag 1273681 gagagaggca caaatgaagc cgttcaaaaa aatctcgaag cctactatca cttagacgat 1273741 cctctcattt tccaatacat tttctactta aaatccatca ttacattcga tttcggacct 1273801 tcaattaaaa aaccgtcgga cagcgtaaat gatatgctgg aacgcggatt tcccgtttcc 1273861 tttgagcttg ggatgacagc gattgtcatt gctgtgattt ctgggctggt gctgggcgta 1273921 atcgctgcac tccgccgcaa tggctttttg gactacgccg cgatgagtct tgcagtactc 1273981 ggcatctcca tcccgaattt tattctggca acattgctca ttcagcaatt tgctgtcaat 1274041 ctcaaactat ttcccgctgc gacatggacg agcccgattc atatggtgct tccgaccgca 1274101 gcgcttgctg tagggccaat ggcgatcatt gccaggctga cacggtcgag catggtcgaa 1274161 gttctgacac aggattatat ccgcacagca aaagcaaaag ggctttctcc gttcaaaatt 1274221 atcgtaaaac acgcactcag aaatgcactc atgcccgtca ttaccgtcct gggcacactc 1274281 gtcgccagca tcttaacagg aagctttgtc attgaaaaaa tctttgccat tccgggaatg 1274341 ggaaaatatt ttgttgaaag cattaatcag cgggactacc ccgtgattat gggaacgacc 1274401 gttttttaca gcgtcattct gattatcatg ctgtttttgg tcgatttggc ctacggtctc 1274461 ttagacccgc gcattaaact gcataagaaa gggtgaagcg tgtgaatctc cctgtacaaa 1274521 cggatgaacg ccagccagaa cagcacaatc aggtgcctga tgagtggttt gtcttgaatc 1274581 aggaaaaaaa tcgggaagcc gattcggtca agcggccgag tttgtcatac acgcaggatg 1274641 cctggaggag gctgaaaaaa aataaattag cgatggccgg actctttatt cttttatttc 1274701 tttttgtcat ggcagttatc gggccctttt tatcgcccca tagtgtcgta cgccaatcgc 1274761 tgacagaaca aaatcttccg ccctcagccg atcattggtt cggcaccgat gaactcggcc 1274821 gggatgtgtt tacccgaaca tggtatggcg cgagaatctc gttgtttgtc ggcgtgatgg 1274881 cagcactgat tgattttttg atcggtgtca tttacggagg cgttgccggc tataaaggcg 1274941 gcaggattga cagcattatg atgcggatta tcgaagtgct gtacggactg ccgtatctgc 1275001 ttgttgtcat tttgctgatg gtgctcatgg gaccgggact gggcacgatt attgtggcgc 1275061 tgactgtgac cgggtgggtc ggcatggcga gaattgtaag aggccaggtg cttcagatta 1275121 aaaattatga atatgtactc gcctcgaaaa cctttggcgc gaaaaccttt cgcatcatcc 1275181 ggaagaattt gctgccgaat actatgggag cgatcatcgt acaaatgaca ttaaccgtac 1275241 ctgccgccat attcgcagaa tcatttttaa gctttctcgg cctgggcata caggctccgt 1275301 ttgcaagttg gggcgtgatg gcgaatgacg gcctgcctac gattttatct gggcattggt 1275361 ggcgcctgtt ttttccggcc tttttcatat ctctgacgat gtacgcgttt aatgtgctgg 1275421 gggacggatt gcaggatgcg cttgacccta agctgaggag gtagctgtat ggaaaaagtt 1275481 ctgtcagtcc aaaatctgca cgtgtctttt acgacttacg gcgggacggt tcaggcggtc 1275541 agaggggtga gctttgattt gtataaagga gaaacctttg cgatcgtcgg cgaatccggc 1275601 tgcggcaaaa gcgttacctc ccaaagcatc atgggcctgc ttccgcctta ttcggcgaag 1275661 gtgacagacg gcaggattct atttaaaaac aaagaccttt gccgtctctc tgacaaagaa 1275721 atgagaggta taaggggagc cgacatttct atgatttttc aagacccgat gacggcgtta 1275781 aaccctacgc tgactgtcgg cgaccagctg ggggaagcgc tattgcgcca caaaaaaatg 1275841 agcaaaaaag cggcacggaa agaggtgctt tccatgctgt cattggttgg tattccagat 1275901 cccggagagc gcctaaagca atatccccac caattcagcg gcggtatgag acagcggatt 1275961 gtcattgcga tggcgctgat ttgcgagcct gatatcttaa ttgcggatga accgaccacc 1276021 gccctggatg taaccattca ggcacagatt ttagagctgt ttaaagagat tcagagaaaa 1276081 acggatgtgt ctgtcattct gattacgcac gatttagggg ttgttgccca ggtagctgac 1276141 agagtcgcag tcatgtatgc cgggaaaatg gcggaaatcg gcacaagaaa agatattttt 1276201 tatcagccgc agcacccata tacaaaaggc ctgctgggct ctgtcccgcg gctggattta 1276261 aatggcgctg agctgacccc gattgacgga acgccgccgg atttattttc gcctccgccg 1276321 ggctgcccgt ttgccgcccg ctgtccgaac aggatggttg tgtgtgacag ggtgtacccg 1276381 ggccagacga tcagatctga ctcgcacacc gtcaactgct ggctgcagga tcaacgagca 1276441 gagcatgcgg tgctgtcagg agatgcgaag gattgaacat gaaaaggggg aagaggatga 1276501 aacgagtgaa aaagctatgg ggcatgggtc ttgcattagg actttcgttt gcgctgatgg 1276561 ggtgcacagc aaatgaacag gccggaaaag aaggcagtca tgataaggca aaaaccagcg 1276621 gagaaaaggt gctgtatgta aataatgaaa atgaaccgac ttcattcgat ccgccgatcg 1276681 gctttaataa tgtgtcatgg cagccgttaa ataacatcat ggaggggctg acgcgtcttg 1276741 gcaaagatca tgagcccgag ccggcaatgg cggagaaatg gtctgtttcg aaagataata 1276801 aaacttacac atttacgatt cgggaaaatg cgaaatggac aaacggagat cctgtaacag 1276861 ccggagactt cgaatacgcg tggaagcgga tgcttgatcc gaaaaaaggc gcttcatcgg 1276921 cattcctagg ttattttatt gaaggcggcg aagcatataa cagcgggaaa gggaaaaaag 1276981 acgatgtgaa ggtgacggca aaggatgatc gaacccttga agttacactg gaagcaccgc 1277041 aaaaatattt cctgagcgtt gtgtccaatc ccgcgtattt cccggtaaat gaaaaggtcg 1277101 ataaagacaa tccaaagtgg tttgctgagt cggatacatt tgtcggaaac ggcccgttta 1277161 agctgacgga atggaagcat gatgacagca tcacaatgga gaaaagcgac acgtattggg 1277221 ataaggatac agtgaagctt gataaggtga aatgggcgat ggtcagtgac agaaatacag 1277281 attaccagat gtttcaatca ggggaacttg ataccgctta tgtccctgct gagctgagtg 1277341 atcagctgct tgatcaggat aacgtcaata ttgttgacca ggcgggtctc tatttctatc 1277401 gatttaatgt caacatggag ccgttccaaa atgaaaacat cagaaaagcc tttgcgatgg 1277461 ctgtggatca agaggaaatt gtaaagtacg tcacgaaaaa taatgaaaaa ccggcgcacg 1277521 cctttgtatc gcctgggttt acgcagcctg acggcaaaga tttccgtgaa gcaggcggag 1277581 acctgatcaa gcctaacgaa agcaaagcga agcagctgct cgaaaagggc atgaaggaag 1277641 aaaactataa taagcttcct gcgatcacgc ttacttacag cacaaagccg gagcataaaa 1277701 agattgccga agctattcag caaaaattga aaaatagcct tggagtcgat gtgaagctgg 1277761 ccaatatgga atggaacgta tttttagagg atcaaaaagc gctgaaattc caattctctc 1277821 aaagctcatt tttgcctgat tatgcagacc ctatcagttt tctggaagcc tttcaaacgg 1277881 gaaattcgat gaaccgcaca ggctgggcca ataaagaata cgatcagctg atcaaacagg 1277941 cgaaaaacga agccgatgaa aaaacacggt tctctcttat gcatcaagct gaagagctgc 1278001 tcatcaatga agcgccgatc attccggttt atttttataa tcaggttcac ctgcaaaatg 1278061 aacaagtaaa aggaattgtc cgtcaccctg tcggctatat cgatttaaaa tgggcagata 1278121 aaaactgatg gaggcgattg aggaaatact gcttctttat gcgaaggagc ggtatttttt 1278181 ctctttcttg cacgtatacg tagggtgcag agcaaatgaa aggagtgttt tcgttgaatt 1278241 acaagccgaa agcgttgaac aagggtgata cagtcggagt gatcgcgccc gcaagtccgc 1278301 cggatccaaa aaagcttgac accgcgcttt tatttttaga agagctcggt cttcaggtga 1278361 agttgggcaa ggcgctgaaa aaccagcacg gctatttagc gggacaggat gatgagcggc 1278421 tggcggatct ccatgagatg ttcagagacg atgaggtaaa agcagtgttg tgcgcatgcg 1278481 ggggttttgg gacaggacgt atcgccgcgg gcattgattt cagcttgatc cgcaaacacc 1278541 ctaaaatctt ttggggatac agcgatatta cgtttttaca tactgccatt catcaaaaca 1278601 caggtcttgt cactttccat ggcccgatgc tcagcacgga tattggcctt gacgacgttc 1278661 acccgctgac aaaagcgtca tataagcagc tcttccagga gacggaattc acctatacag 1278721 aagagctttc tccgctgacc gagcttgttc ctggaaaagc ggaaggcgag cttgtcgggg 1278781 gaaatctgtc tttgctgacg tctacactgg gcacgccatt tgaaattgat acgagaggaa 1278841 agcttctgtt tattgaagat attgacgagg agccttatca aatcgaccgg atgctgaatc 1278901 agctgaaaat gggggggaag ctgacggacg cggcgggaat tctagtttgt gattttcaca 1278961 attgtgtccc ggtgaagcga gagaagtctc tctcgcttga gcaggtgctg gaagactata 1279021 ttatttctgc gggcaggcct gctctgagag gatttaaaat cggccactgc tcgccaagta 1279081 ttgccgttcc gatcggtgcg aaagctgcta tgaatacagc agaaaaaaca gccgtaatag 1279141 aggcgggcgt ttcagaaggg gcgctgaaga catgaaaatc attcgaatcg aaacaagccg 1279201 aatcgctgtc ccgctgacaa agccgtttaa aaccgcactt cgcactgtgt atacggctga 1279261 atcagtcata gtaaggatta cttatgacag cggtgcagtc ggatggggag aagcaccccc 1279321 gacgttagtg attacaggag acagcatgga tagcattgaa agtgccatcc accatgtgtt 1279381 gaagccggca ttgcttggaa aaagcctggc gggctatgag gccattctgc acgacatcca 1279441 gcatcttctt acaggaaata tgagcgcgaa ggctgctgta gaaatggctc tatacgacgg 1279501 ctgggcgcag atgtgcgggc tgccgcttta tcaaatgctt ggcggatatc gagatacgct 1279561 ggaaacagat tatactgtca gtgtcaactc acctgaagag atggcagctg atgccgagaa 1279621 ttatctcaaa caaggctttc aaacgctgaa aataaaggtc ggaaaagatg atattgcaac 1279681 agatatcgcc cgtatccagg aaatcagaaa acgtgtcgga tcagctgtga aactgcgttt 1279741 agacgctaat caggggtgga ggccgaagga agcggtaact gccattcgga aaatggagga 1279801 tgcgggccta ggcattgagc ttgtcgagca gcctgtccat aaagatgatc tcgctgggct 1279861 taaaaaggtg acagatgcaa cagatacgcc gattatggct gatgaaagtg tttttacacc 1279921 gcgccaggcg ttcgaagttc tgcaaacccg gagcgcagac ttgatcaata ttaaattgat 1279981 gaaagcgggc ggcatcagcg gagcagagaa aattaatgcc atggcggagg cctgcggggt 1280041 ggagtgtatg gtcggcagca tgatcgaaac gaagctgggc attacggccg cggcgcattt 1280101 tgcggcaagc aagagaaaca tcacacgctt tgattttgac gcgccgctga tgctgaaaac 1280161 agatgtattc aatggcggca taacatatag cggcagcacg atttcgatgc ctggcaaacc 1280221 gggcctcgga atcatcgggg ctgcgctttt gaaaggggaa aaagagcaat gatgcacact 1280281 gtcatatcag cagtggccaa catctggaca gcgcctgatt cacctcgtcc gtctgatcaa 1280341 ttcatgcttc aaccgactgt aatgatcaga gactggctgg agcgcatgac gtatgatgaa 1280401 cggcttggat tatgtacaga caatgtaatc caaactcagg ttctctttgg cgaaaaggta 1280461 cttgtgacgg cggaacaggg ggaatgggtt tctgtgatcg tgcctagcca gccatcccga 1280521 aaggatccgc gcggataccc gggctggatg aaaaagtacc agctggaaaa aacaaagccc 1280581 atccatacac aacacgatgt gatgatcagc aaacctgctg cctttttgta cagaagcaat 1280641 ggggaaaagg agatcgaatt aagctttttg acagttctgc cccttattgc aaaagaaaac 1280701 ggatatttta aggtttcgac cgtttttggg gaaaggtttg tgaggcaaag tgatgcagtg 1280761 cctgtcagcc aacagaaagg gactgctgaa gacatcattc aaacgggtgc gttttttctt 1280821 ggccttccct acctgtgggg agggatcagc gggtttgggt ttgattgctc cggatttatg 1280881 tacagtatat ttaaggcgaa tggatacagc atcccccgtg atgcgggaga tcaggctaag 1280941 gcagggaagg gtgtcccgct tgatgatatg aaagccggtg atctgctgtt ttttgcttat 1281001 gaggaaggaa aaggagcgat tcatcacgtc ggtctgtatg taggcggcgg gaaaatgctt 1281061 cattctccaa agacagggaa gtcaatcgaa atcctcacat taacagagac aatctatgaa 1281121 aaagaattat gtgcggtgcg ccgctgtttt tcagaataag gagggagaca aatgaggcga 1281181 ctgcctttgt tagaggtcag ccagctgaaa atgcattttg acgcagggaa aaagcggaca 1281241 gtcaaagctg tcgacggggt cacctttcag attcgtgaag gagaaacgtt cgggctagtc 1281301 ggggaatcag ggtgcgggaa atcaaccttg gggagagtgc tgatgcgcct ttatcagccg 1281361 acagaaggaa gcgtgacata ccgcggcaca aatcttcatg cactaagtga aaaagagcag 1281421 tttgccttca accgcaaact gcagatgatt tttcaggacc cttatgcttc acttaacccg 1281481 cgcatgaccg ttcgagaaat tattttggag ccgatggaga ttcataatct ctacaatacc 1281541 cataaagcac ggcttctcgt cgtggacgag ctgcttgagg cagttgggct tcaccccgat 1281601 tttggcagcc gttatccgca tgaattcagc ggcgggcaaa ggcagagaat cgggattgcg 1281661 agagcactgt cgctgaatcc tgaatttatc gtggcggacg aaccgatttc tgcacttgat 1281721 gtctctgttc aagcgcaggt ggtcaacctg ctgaagcggc ttcaaaaaga gaaagggctt 1281781 acgtttttat tcattgccca tgatctttcg atggtgaagc atatcagtga caggatcggt 1281841 gttatgtact taggacacat gatggaaatt acagagagcg gcaccttgta tcgtgaaccg 1281901 ctccatccct atacaaaggc gcttttgtcc tcgattccga ttccagatcc tgaattggag 1281961 gacaagcgtg agcgtattct cttgaaaggg gagctgccga gcccggtcaa tccgccaagc 1282021 ggctgcgtgt ttcgtacccg ctgtccggag gcgatgcctg aatgtggaga atctcgtccc 1282081 cagcttcaag aaatcgaacc cggccgtttt gtcgcttgcc atttgtatcg aaatgctgaa 1282141 acgaaggaaa aagtaagata aataaaaaga gtggctcctt tttactagag ccactccatt 1282201 tgtttatact tgatgtaaaa actttacaca aaccgggtaa gggacagaaa ccgttgatgg 1282261 gaggagtgtc aatcggccgg tttctttgtc tctttcaaac aagacaaggt tgcctgtttc 1282321 ttcatttgaa gcaacgagga acccttccgt tgggtcaaat acaaagtcac gaggccagtt 1282381 tccttctgtc gacactcttt ctacgaaagc cagctctcct gaatattgat tcacttcaaa 1282441 tacggcgata ctgtcatggc cgcggtttgc gacataaaca aaacgtccgt cctgcgtgac 1282501 atgtattgcg cttccctggc tgttatctgt aaaatcatca gggatggcag aaacgacttg 1282561 gatttctcta aattcgccgg ctgtcgggtt gtattcaagc gcaatcactt cattgcttaa 1282621 ttctgtcatg acataagcgt atttttcttt cggatgaaaa gcgatatggc gaggtcctgc 1282681 accgggagcg aaggaatggc ttccggattc agtcaacaca ccgtctttaa gcttataggt 1282741 gtagagctta tctataccta aatcaaccgc taccacataa ttgtgttcag gtgtgaaccc 1282801 cgcgtagtgt gtatgcggtt tttcttgtct ttcgtgcggc ccttttcctg tgtgagcggc 1282861 ctctgaaaca ggtgattgca agctgccgtc ttcctgaacc ggaaaaacgt gtaccttccc 1282921 gctgtgataa ttggcagtca gtacgaattg attttgatca tcaacgctta cgtggcatgg 1282981 cgaagggcca tcaattaact gatgattcag aaatgtcaat tcgccgctgt ttttatcgat 1283041 ttgataggca gcaactccgc cttggccgtc tgctttttcg atggaataaa ggatggtgtt 1283101 gtttttattc gtcgccacat atgtcgggtt gcccagctta gcggccagct ttggctcgct 1283161 gagtgctttt ttctcagtat caagctcaaa tgaataaatt ccttcgcttc cgccttttgt 1283221 atatgttccc acatatccta tgtattttgt catgcgattt cccccttaaa aatgatgtca 1283281 cctctatatt aacgtatctt gataaaataa gctgttcaaa acatgaaaaa ggggaagatt 1283341 cttcattcgc ctcgaatcag cggcattgtg cagcacctga aggagccgcc tgatttaata 1283401 atttctgaca ggtcaatttc gataatgtga tagcctcttt tcgatagctg ttgattgaca 1283461 tggcggttgc cagggagact gatgatcgtt ttttttccga ttgaaaggac gttggtgcca 1283521 agcgtaaatt gttcgtcctc gggcacctca ataagatcat aacgttttgc cagcatatcg 1283581 gctgcatctg gctcaatggc ctgtgaataa attaacgctt cgctttcaga tataatgtta 1283641 aatacgcagt ccaaatgcaa aaatttttca tgaagcttca ctggaacgat cgtatattca 1283701 ggaagtgcct cttctagctg gccgatagct gaaatgtcgg tgcgctggct gattccgaca 1283761 tagacaatgt catcatcgat aatgacgtct ccgccttcaa tactcgtatc aagcatgcgg 1283821 gtgtaagaga taccttggct gtgaaaaaaa tcttttataa cggcttcttc tccttggcga 1283881 atcggttcag tcatgcttga cagaaaggct ttttctccga tgacaaatcc tatgtcccta 1283941 gtaaaaacct gttctgggag tccgtcgcga acgggcaaaa ggacgacctc aacgttgtgt 1284001 gacctaagtg cctccactaa gcggctgtgc tggtcgttag cggtttttac atgaatattg 1284061 tcatcttcaa aatgtttttg tgtttcgttt ataacatctt ttatggtcat gtgctcaggt 1284121 ttgcataaga tcactttttg aagtgtgccg tattccgttc ggcataccgt tttgtgctga 1284181 gatttcggga tggatacgtc catttgtttt tcctcctaaa gtgtgaagaa tacatttatt 1284241 attccctcat catgaaaatc attaaaccat tttaaatttt agacaaatgg aagagaatat 1284301 tgtttaatag gagaatataa gtgcatttag ctaaaagatc agacatcaaa ggggagaaag 1284361 gtatggaaac accggaaaca agattttgta aagagtcaaa ggttgtgaaa accagcaggg 1284421 tgttcccgct tgacacgaac aaccataata cgctgtttgg cggaaaatta atgagctaca 1284481 tagacgacat tgcctctatt tcagcggcgc gccattgcag acgtgaaacg gtaacagctt 1284541 caatggattc tgtagatttt ttaaagccga tcgggcaaaa ggattctgtc tgcctagagt 1284601 catatgtgac atgggtcggc acatcttcca tggaagtatt tgtgaaagtt attaaggagc 1284661 atttgatgac tggcgaacgg gaactcgctg ccacatcctt tttgacattt gtcgcattag 1284721 attcaaatgg caagccggtg cctgtaccga gggttgtacc ggaaacagaa gaagaaatca 1284781 tgctgcataa tacagctgta cagcgtgcta atgaacgtaa gaaccgcaag agacacagcc 1284841 aggcgcttgc aaatgcgctc ggaactgata agccttggtg aacgttaaac ccaaaacata 1284901 agttgttttg ggtttttttg tacttttcaa tggtgattat tacaatggtt agtccgtttt 1284961 tgctagggga ttctataaaa aagcaacaaa tgtcatgtta aattgataat tttgtgacaa 1285021 ctttattaaa gattcatttt agatatatct tttattcgta agatcatgta ttttaaagat 1285081 atattttaaa tacatctttt cgaaaggatt gtttataaaa tgttagataa caaaacaatc 1285141 gaaattatta aaagcactgt acccgtattg caacagcatg gagaaacaat cactggccgt 1285201 ttttacgatc ggatgtttca agaccatcca gagcttttga acatttttaa tcaaacaaac 1285261 caaaagaaaa aaacacagcg aactgcactg gcaaatgccg ttattgcagc tgcggcaaac 1285321 attgaccaat taggaaacat cattccggtt gtcaaacaaa tcggccacaa gcaccgcagt 1285381 atcggaatta agcctgagca ctacccaatc gtcggtaaat atttgctgat tgcgattaaa 1285441 gatgtattgg gagacgctgc aactcctgac attatgcagg catgggaaaa agcgtacgga 1285501 gtcattgctg acgcgttcat cggaattgaa aaagacatgt atgaacaggc tgaagagcaa 1285561 gccggcggct ggaaggagta taagccattc gttatcgcaa aaaaagagcg ggaaagcaaa 1285621 gaaattacat ccttctattt gaaaccggaa gacagcaagc cgttacctga attccaagca 1285681 gggcaatata tcagcatcaa agtgcggatt cctgattctg aatatacgca tatccgccag 1285741 tacagcctgt ctgatatgcc gggaaaagac tattatcgaa tttcagtgaa gaaagatggt 1285801 gtcgtgtctt cctacttaca cgatgggctg caggagggag attcaataga gatcagcgca 1285861 ccggcagggg actttgtttt agatcatgca tcacaaaaag atctcgtttt gatcagtgcc 1285921 ggagttggca ttacaccaat gatcagcatg ctgaaaacat ctgtttccaa acagcctgaa 1285981 cggcaaattc tgttcattca tgcggcgaaa aacagtgaat atcatgcatt gcgccatgaa 1286041 gtagaagaag cagcaaaaca ttctgctgtt aaaacagcat ttgtgtatcg cgagccgaca 1286101 gaggaagacc gtgcaggtga tctgcatttt catgaaggac agattgatca gcaattcctc 1286161 aaagaactga ttgccaacac agatgcggat tactatattt gcggttcacc gtcgtttatt 1286221 acggcaatgc ataagcttgt atcagagctc ggatcagcgc cggagtctat ccattacgag 1286281 ctattcggcc cgcaattaag tttggcgcag tccgtttgaa cacatacatg aaactcttct 1286341 cctttcagag aagagttttt tattgagata taagaaggca gacaagcgcc ggtttctaca 1286401 tccggacaat cacagacccg ctgccatttg tgcatacacg gttttgctgt tcttgcattg 1286461 ttctcagcaa ttcattgttt acctcaatcg ctctaattag ttgcttcatt cttagctcca 1286521 aaccggccag cctgtcgatt gtttgctgct ggtagccctc gggttgggga gccaatggca 1286581 gatcaaaggg ccaaagggta ttcgacttct gatttttcat attgcgtatt gcgcctccaa 1286641 tcggtgtcac tttctattat gttatgttca ggcgatatgc acgttcgcct agacactgat 1286701 gcatagaggg cctgccacgg ggcacaatag gctcaatatg accagcggat ggaggtaaag 1286761 atcggtgtta tggatggtat gggtattttt actgaagcca gttatcgtat tttcgattgc 1286821 atatattttg tttcggcttg ccggtaaaaa agctgtgtca caaatgaaca attttgacct 1286881 gcttttgacc ttcgcaatcg gaaccattat cagtgagccg atccttacat ccaagctgcc 1286941 gatgtcaatt tattatgcgg gtgctttttt ggtgctttat cttatcatga gcaagctctc 1287001 tttatctaat aaatggcgat ggctcctagt cgtgagcccg actgtcctaa tccgaaacgg 1287061 ggatattgat gaacgcggcc ttcgtaaaga aaggctgact gttaatgagc tgctcggaaa 1287121 gctgagggaa aagggctatg ccgacccggc tgacattgat cttgctatca ttgaagaaac 1287181 gggagaagta agcgtcatcc cgaaagagga agcgagagcg gtgcaggtgc gggatttgaa 1287241 tatggaagct gaacggaatt ttatcccgat tccgctcata ctggatggcg aaatccttga 1287301 tcataatttg aaatatctcc aaaaaaaccg atcctggctg tttgagaagc ttgaggaaaa 1287361 agggtacagc cccaaactgc tgtcttcgat tatccttggc acgatgaatg cacgcggtga 1287421 tatatccctt gatttaaata ccgctaatga accgcagcat gatccttact tatataaacc 1287481 gggaaataac aattaagatg gctctctctt gtaatgagag cttttttctt ttttaaaggg 1287541 aatttttgtt tggtgtcaaa tgtacctagt taggagggga actgaacatg aaggacttat 1287601 ccataagaaa cgacatggcg ccaacggtca gtttgctgta ttccgcagtg gaagaaaaca 1287661 gtctccgtct ggcttccatc gtaagccata tgacacacag tgaactttac tataaggggc 1287721 gctgccaaac aaaaaacagc acggctcagc ttttgcacca tatcacaaat gttgatatca 1287781 gatgggtctg gcgtatcaag gaaaatcgga tcccggacca tattgaacag gcatacggcc 1287841 cgatgacaga tgaaagcgga cggctgcctg aaccggtgaa tcagccagac ttagatgaac 1287901 tcctgaaaag acatcagcat gtagtagaga agctgaaatc ggtatgcttc actttaactg 1287961 aaaatgcttt gaaccagccg ctttccttcg aaggtgacac cgcgacgata cgatggggaa 1288021 tttggcatat ggcagatcat aaccgctatc atcaggcaca tattgaagct ctcaaaaaag 1288081 aatggaagca ggatgtggcg aagtatgaac gctaaaacga agcttgtgac tgatcgaatt 1288141 cgtttgcgct gtatggaaga tcgggatcaa gccactttgt ttgggctgct ttttaatgat 1288201 cctgacgtca tgacatatta ttccggttta aaagataaga ggcaaacccg cgagtgggtc 1288261 aattggaacc aacgaaatga aaaagggtac ggcgttagtc tgtggatcgc cgaagataag 1288321 cggacagggg agtttttggg gcaatgcggc atcgttcccc agcagatcga aaatcaaacc 1288381 gtaatggaaa ttggctatat gtttgcccgc cgccactggg ggaacggcta tgcgcaagaa 1288441 gcggctcggg cctgtctgga ctatggcttt aacgagcggc agttcggcaa aatggcggct 1288501 ttgattgatc cgggtaacaa agcgtccata cgggtagcgg agaaaatcgg catgcattac 1288561 agcaaaacga tcagaaaatg gaataaaccg atcgcggtat atgaaagaaa atcttacaat 1288621 tgaaagatag agctgagttt agtatcatga tatcatgtaa agttttctag ggttccgcat 1288681 gtcaattgac atggactggt ccgagagaaa acacatacgc gtaaatagaa gcgcgtatgc 1288741 acacggaggg aaaaaagccc gggagagtca atctcatgtg agacgactgt ccggggtttt 1288801 tttgttttcg gagaatctta atagatagaa aggaatgact caaaatgaaa tggggattgg 1288861 tcgtgcttgc cgctgttttc gaggttgttt gggtgatagg cttaaagcac gctgactcag 1288921 ccttaacatg gagcggcact gccatcggca tcatattcag cttttacctt ctaatgaagg 1288981 cgactcacag tctgcctgtt ggtaccgtgt atgccgtctt taccgggctc ggcacagcgg 1289041 gaacagtact tagtgaaatc gttctttttc atgaaccggt tggatggccg aagctattgt 1289101 taattggcgt gctcttaatc ggtgtaatcg ggttgaagct tgtgacacag gatgagacag 1289161 aggaaaaagg aggcgaggca taatgctgca ctggatcagt ttattgtgcg cgggctgttt 1289221 agaaatggcc ggcgtggccc ttatgaatca atatgcgaaa gaaaaaagcg tgaaatgggt 1289281 gctgttgatc attgttggtt ttgccgcttc attttccttg ctgtcgtacg caatggaaac 1289341 cactccgatg ggaacggctt acgcggtctg gacaggaatt ggcaccgccg gcggggcgct 1289401 tatcggcatc ctcttttaca aggagcagaa agacgccaaa cggatcttct ttatcgcgtt 1289461 gattttatgc tcagcagttg gtttaaaaat tctgtcataa attgattttt atcaaatctt 1289521 cagtataatg gataaatagt ttagacttac aaagataaga gggattattc atgaaatcat 1289581 atatgactca gcggttggac gaataccgtg acggaaatga ggataaaggt cggctcttgg 1289641 tcagctgccc cgatcagccg ggtatcgtct ctgcagtttc cgcgttttta tttgaacacg 1289701 gtgccaatat tatagaatca aatcaatata cgacagaccc tgaaggcggc cggttcttcc 1289761 tgagaatcga attcgactgc gcaggcattc gtgaaaaaaa atcatcactt caggcagcgt 1289821 ttgcctctgt tgcggaaaaa ttcgacatga catggagctt aactttggcg agcgaactga 1289881 agcgtgtcgc cattttcgtt tcaaaggagc tccactgcct gcatgagctg atttgggaat 1289941 ggcaaaccgg caacctgatg gcggagatcg ctgttgtcat cagtaaccat gaggaagcga 1290001 gagagctggt tgagcgcctg aacattccat tccactatat gaaagcgaac aaagacatca 1290061 gagcggaagt cgaaaagaag cagcttgaac tgctggagca gtacgatgtt gatgtgatcg 1290121 tgctcgcacg ctatatgcag attctaactc ctgattttgt ttcggctcat ccgaatcgca 1290181 tcatcaatat ccaccattca ttcctgccag cttttatcgg tgcgaatccg tacaaacggg 1290241 cctacgagcg cggcgtgaaa ctgatcggtg cgacatctca ttatgtgaca aacgatcttg 1290301 atgaagggcc gatcattgaa caggatattg agcgtgtgga ccaccgcgat aatgcggaag 1290361 cgctgaaaaa catcggaaga acaattgagc gcagcgtgct tgcccgtgct gtgaaatggc 1290421 atttggaaga ccgtgtcatc gttcatgaaa ataaaacaat cgtctttaac tagactgcaa 1290481 gaggcccgcg caatgcgggc tatttttgat gacaaaaaac cttgacaagt gtcttttttc 1290541 tttgcataat ataaaaaaat cattgagcgt tgaagaggat tagtaagcag acctttctgt 1290601 gacagagagc aaaatgaatc gctgaaacat tttgccgcat gaaacctgcc gaacctgcct 1290661 tggagtccta gggggaaaac ctaggcgcat aacctggcgt tacaggagag cggagcgtgc 1290721 acaagcgcgt tcaatcaagg tggtaccacg gaaacccatt tcgtccttat gaatcaggat 1290781 gaaatgggtt tttttattgt agaagagccg cggaggagaa taaatgaaaa aacaaagaat 1290841 agtagtgaaa ataggaagca gttcgctcac gaatagcaaa ggaagcattg atgaggcaaa 1290901 aatcagagag catgttcagg cgatttccgt gttaaaaaaa gcggggcatg aaatgattct 1290961 gattacctcg ggtgccgtag cggcggggtt ttccagcctc ggttatccat cccgtcccgt 1291021 taccatcaaa ggaaaacagg cggcggccgc ggtcggacaa acactgttaa tgcagcaata 1291081 tatgaatcaa tttaaacaat actcactgac tccgggacaa atccttttaa cgagaaatga 1291141 tttttcgaaa agagaacggt atcgaaacgc gtatgctacg ataatggaat tattagagcg 1291201 gggcgtcatt ccgattatca acgagaacga ttctacatct gttgaagaat tgacattcgg 1291261 agataatgat atgctttctg cgttagtcag cggattgatt cacgcggacc agctcatgat 1291321 tctcactgac attaacggac tgtatgatgc caatccaaat gaaaatcctg aggcgaaacg 1291381 atttgattat ttgccagaga tcacgcctga attgcttgga tatgcaggtt cagctggatc 1291441 aaaggtcggc accggcggaa tgaaatcaaa gctgttagcc acacaaaccg cgctgtctct 1291501 gggagtgaaa gtattcattg gaactggcag cggagagcaa aaacttgcgg acattttgga 1291561 cggcagggga gacggcactt atatcggaga caaagaacta tcttcggtta acaacacaag 1291621 gcagtggatt cagttccact cgccgatatc gggagaaatt atcattgatg cgggtgccga 1291681 agaggcgatg atccataatg gaagcagcct tttgcccgct ggagttgtgg gcgtgaacgg 1291741 aagctttccg aaaggggcgg ttgtggaagt caggggaccg ggcggcgtga tcggcaaagg 1291801 ccaaactcat tactcctccg aggagattat ggaggctaaa ggcaaacgca gtgacgaact 1291861 tgattttgag aaaacgtttg aggttattca taggaatgac tgggtcaatg taaaagacta 1291921 ggaggcggaa aaatgagtga agtttctgta aaagcgaagc tggcgaaaga agcagcagcc 1291981 gaaatgatca tgaaaacaac agccgagaag gatgaggcgc tcagcctcat tgcaaacgga 1292041 ctccgcaaag aactggattt tctcttggcg gagaatgcaa aagacattgt gaacggaaaa 1292101 gagaatggtt taacaccgga catcattgac cgtctctcat tggatgagaa acggatacgc 1292161 gatatcgcgg acgcggtgga gctcttaatc gacttagcgg acccaatcgg cgactctctt 1292221 gaaacgattg aaaaagaaaa cggcctgttt attgaaaaaa tccgtgtgcc gctcggtgtc 1292281 gtaggaatga tttatgaggc gaggccaaac gtcacagttg atgcggctac cctttgcctg 1292341 aagacaggga acgcggttgt gctgcgggga agctcctcag ccatccacag caacaaagcg 1292401 ctcgtcagtg tcatttacag agcacttgag caatcagcgc ttccgattca cgctgtgcag 1292461 ctgattgagg atacgagcag agagacagca aaagagctct ttacgttaaa tgatggctta 1292521 gacgtattga ttccgcgcgg aggcaagaaa ctgattgatc tcgttgtgag agaatcaaca 1292581 gttcctgtat tagaaacggg agcaggaaac tgccacatat tcattgacga aacagccaaa 1292641 ccgcaaatgg cagaaaaggt tgttgtaaat gccaaaacgc agcgcccttc tgtatgcaac 1292701 gcgattgaat cattgctgat tcacaaggct tgggcaagac agcacggaaa agaattgctg 1292761 gaccagctgg aaaacgcggg agttgaaatt cgcggtgatg aattggtatg tgaacttcat 1292821 ccttcaagca aacaagcatc aaaagaagat tgggaaaccg aatttttagc gcctgtcctc 1292881 agcgtaaaga cggttgaaaa cgtccaagaa gctgtaaagc atatccaaca atacggcacc 1292941 aatcattctg aagcgatttt aactgaaaat gacaaaaatg cggtatattt tcaaacggct 1293001 gtcgatgctg ccgctgtcta tcataacgcg tcaacccgct ttaccgacgg ctttgaattc 1293061 ggctacggag ccgaaatcgg catcagcacg caaaagcttc atgcaagagg accgatgggg 1293121 cttcctgcac tgacttctac aaaatacatc attaaaggaa ctgggcaaat ccgtgaatag 1293181 cggggtaatg ttcaatgaaa aagcttatct cattacgaga taagcttttt tatacgcgaa 1293241 aaattgacat ttcaaattta attgtgtaca atttaattgt ataaaatata ttgggggaat 1293301 gaaaaatgag tcagccatta tttaccgcaa ctgtttcagc ggtaggagga agagaaggaa 1293361 aggtcatttc atcagaccgc gttcttgagc ttgatgtcgc aatgccgggg acaccgagag 1293421 ccaagaaatt agaaaaagcg acaaatccag agcagctgtt tgcagcaggt tatgcagctt 1293481 gctttgacag cgccctgcag cttgtcgcaa gaacagaacg ggtaaaagta gagacagagg 1293541 ttacagcaaa tgttagcctg ttaaaggatg aagcggacca gggctataag ctgggtgtga 1293601 cgctgcaagt aaaaggagaa ggagtcagtg catcagaatt ggaggcgctt gtgaaaaaag 1293661 cgcacggcgt ctgcccgtac tcaaaagcaa cctccggaaa tattgatgtg acacttgaag 1293721 ttgctgaata aataaaaaga ggatgcctgt acaaggcatc ctcaattttt ttgatgaagt 1293781 gtttccagta atgtatatag agcggacttt aactgtttga gatcctcccc agactgcttt 1293841 gagagcccca gaattgtccc tggaatgtca accgcttttt cttttaataa cgctccgtcc 1293901 tctgtcaggc tgatcaacac ggaccgctca tcctcttcag atctttttct cgtaatcaaa 1293961 ccctgttgtt ccattcgttt aagcatcgga gtgagcgttc ctgaatctaa atacagctgt 1294021 tcgcccattt ttttgacagt aagcgtttca tgttcccata acaaaagcaa agccaaatat 1294081 tgagggtatg ttatattcag cttatcaagc agcggcttgt attgctttgt catctcccgc 1294141 gaactcgcat atagcaaaaa acaaagctga ttctccaatt tcatatgatc aaatttattt 1294201 tccattttgt tcaccaactc ttttttgtca ttcgattcta ttgtatctga aaaacctcac 1294261 ttttcctatt ctcggcaaac atagcatgtt taaaaagatc agaaagggaa atataacaac 1294321 tagatacaaa taaggaggtt gggaaatatg gcactattta cagcaaaagt aaccgcgcga 1294381 ggcggacgag caggacatat tacatcagat gacggtgttc ttgattttga tattgtcatg 1294441 ccaaatgcca aaaaagaagg acaaaccggc acaaatccgg aacagctctt tgcggcaggg 1294501 tatgctgcat gcttcggcgg cgcgctcgaa cacgtagcca aagagcagaa tatcgaaatt 1294561 gattcggaga ttgaagggca ggtcagcctc atgaaggatg agagcgacgg cgggtttaaa 1294621 atcggtgtca cacttgttgt gaacacgaaa gatttagatc gggaaaaggc acaagagctt 1294681 gtcaacgccg ctcatgaatt ctgtccttac tcaaaggcaa ccagaggaaa tgttgatgta 1294741 aaactagaat taaaataatg accggcatcc tgaggattct caggatgttt tttggtgtcg 1294801 gacatgcggg gcgggcacag atttatgata aaacttcaga gaagcgtttg aagcatgcct 1294861 ttaaaccaaa agttacagat gaagcgggtg gctggcacgg tgtctgccgt gctgaattgc 1294921 gcgtatatgc tgttttgtat ttgcacaggg catagcggct acttggagaa ataacaagga 1294981 ccaggccgcg catgcctgat ccttttaata ttctttctta ttggcgaagt tccgccatgc 1295041 ttgaaacggg gataaatgct ctgttagtgt cacttgataa aaggggatcg ttctttcttc 1295101 agcaggttta tcaatttctt tataaatgaa tgaatcatca aacccggctt cggcagcgtc 1295161 tgtgtgctca gctgcataga aaacggcttt aggccgggcc cagtagatgg cgcccaagca 1295221 cattgggcat ggttcacagc tcgtatacaa aatgcagtca tcaagctggt aggctcctag 1295281 caccttacag gctttccgaa tagctgtgac ttccgcgtgg gcagtcggat cattgcttgt 1295341 tgtgacgttg ttctgtccct ctgcaataat ggctccgtct ttcacgataa cggctccaaa 1295401 aggcccgccg attcctgcat tcactccttc acatgcgaga gtgacagccc gttttaagaa 1295461 cgtttcatga ttcatcccaa tccctcctgt caatagagtg ttattagtat agccgaaaag 1295521 aatgcaaaga acattcttaa aaaagtgcaa aataaacaaa gtatttgggg gatttgctaa 1295581 ataagaaacc gattgtggct gtattataga aaaaaaccat ctgccaaatg cagatggttt 1295641 tttcaaatta tactagctgt gtctgctgtg ctcttgcctg ttttgcggct tcaaccatat 1295701 ttttcaatgc tgcaaccgtt tcttcctgct gtcttgtttt caatccgcag tctggattta 1295761 cccagaagcg gtcagtcgga cagacggcaa gcgcatcaac gataatattg tacatttctt 1295821 cagttgacgg cacacgaggg ctgtgaatgt catatacacc aaggccaagc cctttcaaat 1295881 acgggtggtt ttttaagtaa tctaaaaatc ctccgtggct tctgctatgt tcgattgtaa 1295941 tcacatcggc atcaagatca ttgattgtat caacgatatc ttcgaagttg ctgtagcaca 1296001 tatgtgtatg aatttgtgtc tcgtttttca cggaagaagt ggttaatctg aaagcttctg 1296061 ccgcccaagt caaatactca tcccaatcgc gggttttcaa tggaaggcct tcacgcagcg 1296121 ctggttcatc gacttgaatg atttgaatgc ctgcgtcttc aagcgcttta acttctttgc 1296181 gaagggcaag cccgatttgg aaggcgattt ctttcctcga gatgtcgttt cgagggaaag 1296241 accagtttaa gattgtaacc gggcccgtca gcattccttt cacatgcttg gaagtcaatg 1296301 actgtgcgta gactgtgtct ttcactgtca tcggttcaat aaattcaaca tctccgtaaa 1296361 tgactggcgg gcggacacag cgtgagccgt atgattgaac ccaggcatat ttagtgaagg 1296421 cgaaaccggc cagcttttca ccgaagtatt cgaccatgtc tgtccgttca aattcgccgt 1296481 gaacaaggac atcaagctcc aattcttcct gaatatcaat ccatcttttt gtttccgcat 1296541 tgataaagtt ttgatactgt tcatcggacc actcagcttt ccgccatttt tggcgtgcgc 1296601 tccgcacttc agcagactgc gggaagctgc cgatcgttgt cgtcggcaaa agcggaaggc 1296661 cgagagattc attttgtagg gctaaacgtt cttcaaacgg aatcgggcgc ttgaagtctt 1296721 tatcagttaa ttgctcaagc tctttctttt gttcagaatt ggcgcctgtt gcaaactgtt 1296781 taagcgcctg gatatcagcc ttagcctgct gaatctcttc gctgatcgcc gcttttcctg 1296841 atactaagcc ttctttcaaa gctgtcagct cggccagctt ttcttttgcg taggataatc 1296901 cgttcaatag gtctttttcc aaatgctcat cagggtgttt cgctactgga acatgcagca 1296961 ggctgctgga aggctgaatc cacagttcat caacttttgc aatgctgaga atatcaagaa 1297021 cggcatcgag acgctcttca aggtccgctt tccaaatgtt gcgtccgtcg ataacgccgg 1297081 ctgccagcac tttatctgtc gggaagccat gtgttttaag ctgttccagg tttctgcctt 1297141 tgtcgtgaac gaaatcaagg ccaattccct gaaccgggta agagatcagc tcttcataag 1297201 catcaacaga atcaaaatac gtctgcaaaa gcacattcaa ggatgaaagc tcacttgtaa 1297261 tgctttcaaa taattctttt gcgccgcgta catcttcact agaggcggta acgagcgccg 1297321 gctcatcgat ttgaacccat tttacgcctt cttcttcaag ctctttcaaa agctgtacat 1297381 ataatggcac aaggcgtttt tggatcgctt ttgcttcaga cggttcatag cctttagcaa 1297441 gcgtaacgaa cgtataaggg ccgacaatca caggctttgt ttccacaccg tattcctgtt 1297501 tgatccggcg ataatcttcg agttgtttgt ttcttgtcag acggaactca atgctctcgt 1297561 catattccgg aacgatgtaa tggtaatttg tattaaacca ttttgtcatt tcactagata 1297621 cagcgtcttt gattccgcgg gcgatagcga agtatgtatc ggtagcgtca gtcaaatgtc 1297681 tgaaccgttt cgggatccag ttgaagctga ctgctgtgtc gagtacatgg tcatactgtg 1297741 tgaaatcaga aacaggcaca acatcaatct gctggtcaat ttgtgttttt actgcggata 1297801 aaaatagttc gtcgatttgc ttcaaaaacg tatctttatc agtactgcct ttccaatacg 1297861 cttcaagtgc ttttttccat tcccggttca gtccgattct cggaaatcct aaattcgatg 1297921 ttttgatggt tgtcattgtt tctcctcctt tatatgtaaa acactctctt tcacccgcgg 1297981 atacaggctg ctaagaggtt ttctcacaac aaaaagcctc tttcccatga gagaaagagg 1298041 cttttctacg taaaacactg cctctctcat ctctcagaca caatctgatg gaattagcac 1298101 cgtgccttat gagacatcag tctcggcgcg aaaagcagtg cgccccattt cacaatggta 1298161 ttacggtcgg ttgctgttgg ggtcaaaagg ccaatccctc gcccaactct cgataagaga 1298221 aaatgttatt aattttttga aaagttgaat catttgttgg taatcttaac agtaattcaa 1298281 attcattgtc aacatagaat ttgaaatttt tatttacatg atgtggtgta tattatataa 1298341 gaaaaataat cttatagggt caacaaatgt gattgctctg ctttttctgc gagctcatca 1298401 ggagctgtta aatacaggaa tccattgcct gccagcgttt ttgcaatatc aagaggaagt 1298461 gtcctgcgga ttagctgtgc gaaaacctca gattcagaaa gctttctttg aaatgattct 1298521 tcttcatagc ttttgattaa agcaagcgca ccgctgacat gaggggcagc cattgaagtg 1298581 ccggtcagct taccgtactt cttgttggga agggtggata agatgttttc tcctggtgcc 1298641 acaaggtcaa tctctttatt cgcgttagaa aattctgata attctcgcgc tacagaaaca 1298701 gatccaactg caatcacttc attataagct gcggggtagg aaagctcttc tgtgcgttcg 1298761 tcgccgtcac cttcatttcc cgctgcacaa acgacaagca ctccgttttt cactgcgttt 1298821 ttcactgctt cttttagctc tggcacatcg cttggccctc caagggacat tgagatgatg 1298881 tcgactttct gttccaccgc gtagttgatg ccgttaatta tccattcgta ttgtccgctg 1298941 ccgttctcgc cgccaagaac cttcacaatc aataggcttg cctcaggcgc gactccggca 1299001 atgcctccgt ttgaatcatt agctgcaatt gttccggcga cgtgtgtgcc gtgtccgttg 1299061 tagtcggaaa tcgcatcttc cttgccgccg tcgtcatccg tgaagttctt tccgccgatg 1299121 atttgatttt ttaaatcagg gtggcttgtg tcgcagcctg tgtctaatac agcaacttta 1299181 atatttttgc cttttacccc ttttgcccac atttctggcg ccttaatcac tttaatgccc 1299241 tcaggaagct cgtttacatc catgatctgc tcattcgtca catacgggat caagcggatt 1299301 tcaccattca taaaaaagcc ctcctttttt atgcttgcaa gtggattcaa gggtgttgcc 1299361 tcatattata tgaaaaaagc aagcgctcgg acagagccat ttgaagcatt ttgaaaaaat 1299421 aggatacaca ccaaagaatt agtaatcttc aaaatattgg atggcttcaa catgtatgac 1299481 tgggattcaa ctgtaagtca agttataata gtgttgggga aaggagcagt gtcatgaaac 1299541 tgaatgaaaa attatatgca tttttttcag agcatgtgga acaaatggcc gaggaatgga 1299601 ttgaaacgat ggaggaaagt gatccgaatt cgctttacgc cctacataat gcaacagtaa 1299661 cggaagaatt gaaagagcag gacagagaat tttaccggca tctgaattac atgtatgttt 1299721 taccggaaaa acaatttctc gaagagtttc aagagtgggt cattgagctg accaacgatc 1299781 aaaaacatct cgacacaccg gttcagtatg tcattcggga gtttatgaga aacaggagat 1299841 tatatacgaa gtattttgag aagttcgcag aagaaaatga atcagcgttt gaaccgggag 1299901 agaagcaaaa atgggcagat ttgattgtaa aagtatttga tttcaccatt tatacattcg 1299961 ttgatcacgc tgaaatgaat gccaagcagc aattaaacgc ccaaagagaa atgatattgg 1300021 aattaagctc acctgtcatt accctgagca aatcaacagc tctgctgccg cttgtcggtg 1300081 acattgatac cgaacgggcg aagtttattc tggaaaacac gcttcaagct tgtgcgaaaa 1300141 gacgtgtgga gcatctgtta atcgatctgt caggtgttgt tgtggtggat acgatggtgg 1300201 cgcaccagat ctttaaattg attgaggcgc ttaatctgat cggtgtccgg tcaaccctgt 1300261 caggaatcag gcctgaaatt gcgcaaactg ctgtacagct ggggattgac ttttcgaata 1300321 ttactattaa aaccaacctt gcccaagcat taaactatca tcaataaaaa aatccgctat 1300381 ctgtgatagc ggatttttta tgatgcgaaa cataaagata cgagaaagga tcccgcgaat 1300441 aataagagga cgaggcaaaa gaacacccag tcgcgccggt tcacgctcaa tgtcctgtag 1300501 tatgtccggt ttctgcttcc tgtaaatcct ttcgattcca tcgcaagcgc tgtccgttcc 1300561 gcttttctga tggcgcttgc caatagcggt atggtatatc gttttaacgc actgatttta 1300621 ttaatgatgc cgctctccgc cgctcctcct ctgattttat gagcctgctg aatcagctgg 1300681 acctcatcct ttaacagcgg aagaaagcga aagcctgcaa tgacaccgta cgcgagcttt 1300741 ggtgagagcc tgcactgctg gacaaggctc agcataaata gaatcggatc ggttgtaaaa 1300801 acaaacatca tcgataaggc ggaaaagcat aaaatacgaa acccgagaga gatgccgaca 1300861 gacacattat cgctgttaat ggagataggg cctgcttgaa acaaaaaatt atccggtgtt 1300921 gtcggcactt ttccaaaaac tgcggctgtc cacacgcatc cgaatgctaa aatcaaaaac 1300981 ggaatcgtaa acaacaacca ttttttcaat gggattccgg ccgccagtaa aacgcccgca 1301041 acgatgatga tataaaaaca tgccggagtg taagggttgt aaataaacga cagcatgacg 1301101 acacaacaaa aaaccgccgc cgctttcaca gtcggattaa tgagatgtaa cggttgcttc 1301161 atcacgcacc tcctcttgaa atgccatcca ttcatataga aggggaaggg tgagctttgc 1301221 tttttgaaca agccctgttt cttgagaaaa caactgcgct ggagatccgt caaaggccag 1301281 gcctgtatcg tgaagcacaa gcacgctgtc agcatacgaa gagactagct ccatatcgtg 1301341 tgtaatcata aggacagcag ttccctctgc cttgatacgt tgaatcattt ccatgcattc 1301401 agccgccgtg cgggcatcct ggccaaaggt tggttcgtct aataataaaa cctttacgtc 1301461 atgcatgagc atagtagcta cgctcagtcg ccgtttttgc ccttggctga tcgcaaacgg 1301521 atgatgatca gccaaatgcg caagaccaaa acgctgcagc aggtgttgcg cttttttctc 1301581 agtttcagca tttgctttct ggccgaacag aagctcgtca tacaccgtat cggtgacgaa 1301641 ttgatgctca gggttttgaa aaacaaatcc catccgttta cgcaattctt tttctttata 1301701 tttctgcagc ggctgatcat agagaaggat tttgccgctt tgcggtttca tgagactggc 1301761 cagaactgat aggagcgtcg attttccagt tccgttcgga ccgacaagcg ccgttaaaga 1301821 gccttcgcgc aacgaaaagc tgatgtcttt gaaaatcgcc tgctgtcctc tcgcgaacga 1301881 aaggctgctg acttcaagca cactctcccc agaaggggct ttcttctttt tgacatgccc 1301941 ggcaggaata ggctctttga acagcatctc ttttgataaa gtaaacggca tactcagctt 1302001 ttcctgcaga tgacagacct ttggaatggc gatgcccaat ttctttagtg tctccgcttc 1302061 atgctgaaat agatttttcg tcaggccatc cagtgccttt ttgcctgatt tgtcgagtac 1302121 gatcgttctc tcaatccaag gcgcccattc atcaagctgg tgctcaatga cgaggaggct 1302181 gaaacctttt tcccgctgaa gatccttcat cagatgaacg aactcccgag ctgagaaagg 1302241 gtctaaaaga gaggtcggct catctaaaat aataagctca ggctccatcg ccaaaataca 1302301 ggcgagagcc actttctgct tttgtcctcc tgaaagggtt gagatcattt tttcttttaa 1302361 atgggtaatg cgtaattttt ctaatacggc gttgattttc tctgtcattt cttcttttgg 1302421 aatttgcaga ttttccagcc cgaacgctat ttcgtcctcc accgtcagca tgcagaactg 1302481 ctgatcagga tcctgaaaaa cgaccccggc atgctgagta atcgtttcgg aggtttcagc 1302541 atctgtgacc ggcttttgaa atagaaatac atgtccggac tgaatgccgt cgcaagcctc 1302601 cggatataga ccgtttaaac aaagggcgag cgagctttta ccgcatccgc tcggtcctaa 1302661 taataaaaca cattctcctt tttgaagctc aaacgaaatg tcttgaaaaa ccggtttctc 1302721 gtcttcttca taagagaagc tgagctgctc aaccgtcaga agctcatcaa aggcttgcat 1302781 gttctgacgc ccgcttccgt ttctttttca gttcctttcc gagtgccatt ccgtttaaca 1302841 cacctgtata agcgagagag tcgctgacag cttttccgag aagccccgcc aaaagcgcgc 1302901 cggaaatgag gcggatcaca agcataatga gcagataacc tggtgaatag gctgcatagc 1302961 cagaaacaaa gagatcatag ataaagctgg ctactgaaga ccccataccg gccagcataa 1303021 ggacagggag agagtatgct ttccagcgtg ttgcaagaaa tacagcctca gccccgagcc 1303081 cttgaacaat gccaatgacg atgaccatcg ggccagacgg atttcccagc aggcactcaa 1303141 cgagagcggc aatgatttca gaaacgagcg ccgcacccgg ttttcgaatc atgtacgcgg 1303201 cgatcacaga aacgataaac caaatgccgt aaattggttc ataggcgatt ggcccaaaca 1303261 tacctgcaag tacgtttccg aaatgtgtaa ataataaata aacaacggca aatacgatac 1303321 tgataacgga catgatgaca atttctttta ctttccagct tttcatgtta tccctgcttt 1303381 ctgttttttc ttgatggact gttagccgaa agattcacag tcatggtgat gtggtttgtt 1303441 tgctgctcag ccatgcggaa aacggcctcc aatgtgctga atacgtcatg cgcatccccg 1303501 tcaagctcgc tcgcgtaatg gacaccctgt acgaaagtgc cttgggcttt tgcaatgtcg 1303561 acagcctcca taatcaatcc catataatcc ggctcattca ttggataaag ggcaaattgg 1303621 cacggcgctt ccgccttcaa gcctcggaca gcatcttcat tgacacgctt atcacctttg 1303681 gaaagatatg tatccccctg tgtgtcaccc gggcatccaa tggaaaacgt gccgttcatg 1303741 acgatgtgtt gttcgctgtt tgctgcatga aggtaaatgg cttttgcagc atcgaataca 1303801 tgatcaatcg atccgcgtaa caccgtgctg atatggtcgg ttttcgtcca aaccttggat 1303861 gtatctgttt ttttcagcgc agacttgatc acactgataa aatcatccgt catcggatat 1303921 aaagagaagc gaaaaccggc gattctgctt gtaccgcaaa tatgctccat ttctccgacc 1303981 tcctgttttt ttggtaaaat aaaaaactgc atatcctaag ggaatatgca gtcatagatc 1304041 gattaagcgc acaaaaaaat acaccattcg gtcaacctgc acttccccac gctggtatta 1304101 tccagatcgg gtcataaggg atcaaagcgc gtttcttccg cgctttatct cagccaaaac 1304161 agcaccccta gtgctttccg tatacaattt tttattttga catcataata gatgataaga 1304221 atcattttgt aaacaacgaa atcatttttt tcatataggg acgggagagg atggtcaaat 1304281 ttggaaaaag gacacatatt aattgtggaa gatgaagaaa aaatcgccag ggttcttcag 1304341 cttgaattgg aatatgaagg atacagcgtc acgatcaaac acaatggcac agaaggtctt 1304401 gatgcggcag cggaaggcgg gtattccttg gtgcttcttg atgtcatgct tccggggctt 1304461 agcggactgg aagtgctgcg ccgcttgaga aaaacggatt cgcagacacc ggtcatatta 1304521 ttaacggcgc gagacagtat tcctgataag gtaacaggtc tggacatcgg tgcaaatgac 1304581 tatgtcacca agccgtttga aatcgaggaa ttgcttgcga gaatcagggc ggcgctgcgg 1304641 caaaatggaa caaaaactga agatatcggc acctttctta catatgacga tttgcgggtg 1304701 aacgaaaaaa cccgtgaagt gagacgcgga gacaaagagg tggaattaac gccgcgggaa 1304761 tttgatctgc tcgtctatat gctaaagcat ccgcagcaag tgctgacacg ggagcaaatt 1304821 ctaagctcag tatggggatt tgattatatc ggtgatacaa atgtcgtgga cgtctacata 1304881 agatacatca gaaaaaaact ggactatcct tacgaaaaac agctgatcca tacgattcgc 1304941 ggggtcggct atgccattaa ggggtaaacg atgaagctga agaccaagat tcatctatac 1305001 acttcgatat cactgttgat tttattaatt ttggttcata ccgcagtata tctcattttt 1305061 tcgtctgcgc tgacatcaaa ggatgcggcc cggcttgctg atgagacgga taacattgcc 1305121 gaagcgctgc gtgccgctga aacagaagga gtggctttgc aggatatgct gcaggcctat 1305181 cttccggcaa atggcatggt gcgtgtagtg aatggtgatc aaaaagccgt tatgacgatc 1305241 acaaaagaaa aagcctataa agattttcct ctctcttttc atagcggcga aacggcagat 1305301 gtgaggaaac ctgacggcaa gctgtttgcc gaggctgctg ttccggtgat ttggaccgat 1305361 ggacaagtcg tgtctcttca gctggttgaa agactggaga acacagaaga gagtctgttt 1305421 ctgctgaaaa tcatcttaat cgctgcaagt gctgctgtct gcattgcttc tttttttgca 1305481 ggcagcttgc tagcccgccg aatcatcaat ccgatcagac gattaatgat cacaatgaaa 1305541 gacatacagc gagacaaaga atttaaaacg atttctttag aaggacagtc caacgatgaa 1305601 ttgtatcaaa tggggctgac atttaatgaa atggcaatga tgctgaagga gcactatgat 1305661 aaacagcagc aatttgttca agatgcttca cacgaattga aaaccccgct cactattata 1305721 gaaagctaca gcagcctgat gaagcggtgg ggtgcaaaaa agccggaggt gcttgaggag 1305781 tcgatagaag ccattcactc agaagcggtg catatgaaaa aactgaccaa tcagcttttg 1305841 gcgctggcca aaagccatca aggactcgag gttgatctga aaacaatcga tctgattaaa 1305901 gcggcgcgcg cggttatgca aacgctccag tccgtttatc agcgtgacat attgcttgaa 1305961 acagataaag agagcctgct tgtaaaggca gatgaagaac gcatcaagca gctgttgacc 1306021 attttgcttg ataatgcaat aaagtatagt gaaaagccta ttgagatgtc agccggaacg 1306081 aggaatggac ggccatttct atcagtgagg gatgaaggca tcggaatacc tgaggagcat 1306141 atcccgcatt tgttcgaacg gttctaccgg gcagatgagg cacgaaacag aaaaacaggc 1306201 ggaacaggtt taggcctttc cattgccaag caaatcgctg atgagcatgg cattgagctg 1306261 tctgtcaaaa gcaagccggg acaaggaaca gctgtcacca tgcaattcag cgaacagaat 1306321 gggggaggcc gatgactaaa acaataaaaa cagtatcttt tgctgcagca gccattttag 1306381 ttgtcatcat ctgtacgttt ctcatcattc ggcaaaccca tgagaacgta ttgtcaaagg 1306441 agactgtcgt aaaaaaagtc gaagcctctt atgaaggcaa ggtcacgaaa gcaacacaat 1306501 caaaggataa aaaaacatat gatataaccc ttgaaaatcc aaagggaact tactttgtaa 1306561 aagcagacgc aatatcggct gacattcttt caatgaatag agtaaaagca gtgaatccat 1306621 ctgccatgac agaaaaagaa gccgagcatc tcgcgcttga gcgggtgccg ggaacggtca 1306681 aaaaacaaac acggcaaagt caagttgcca cttataccat acaaaaagaa gacgggaaaa 1306741 catacgaagt gaaggtagac atgcaggcaa aaacagtctt gtctgccgat caaatcagca 1306801 gcaaagatca acaaaaaacg ccgattacga aaaaagaagc caaaacaatt gcagagcgaa 1306861 aaacgggcgg aacagcggat gacgcagatc tcgaagaaag tgagggcact ctcatctttg 1306921 aagtagacgt tgatcttcct gataataagg aagcgacagt gaaaatcaat gcctacacag 1306981 gaaaggtagc taacattgtg tatgaagact gacggtttct catcaaattc tcatcttgct 1307041 ctcgttttcc tttcatgttg agtatgtaaa ctgtactcat acaaaacaaa ggagggctca 1307101 caaatgctca agaaaaaatg gatggtcggt cttttagcag ggtgcctagc ggccggagga 1307161 ttcagctaca acgcgtttgc cacagaaaac aatgaaaaca gacaggcttc ttctaagacg 1307221 gatgcactca ctgaacaaga agcagaagca attgctaaaa cagttgttga cggcacagta 1307281 gaagacattg acagagacct ttacaacggc aaagaagtct atgaagtgga gattgaaaaa 1307341 gaaggtgaag actacgacgt ttatgtagat attcatacaa aacaagcgct taatgacccg 1307401 ttaaaggaga aagcagaaca agtcgccata accaaagaag aagctgaaga aattgcttta 1307461 aagcaaacag gtggaaccgt aacagaaagt aagcttgacg aagatgacgg tgcttacatc 1307521 tatgaaatgg aaatccaaac gaagcaagga actgagacag aatttgaaat ttccgcaaaa 1307581 gatggacgca ttatcaaaca ggagatagat gactaatcaa aacccccgct gcagcggggg 1307641 tttttcatga taagaaacct tcttttggac aatctaagta gaaaaggagg cgaaacgcat 1307701 ggaaaagaaa gaggagcaat acatcaatca ggctgaatat gtccctcatc cgacgaagga 1307761 aggagagtat gccttatttc ttcatgaaac gtatcatttg ctttctgaag atgacgagac 1307821 acaaacaaca gaataagggc ttaggccctt gttttgttcc gtaattgtga tgtaagcgca 1307881 tttattactt ttttgagttg acatagcttg tttttttctg taatctcagt gtgtcaattc 1307941 aattaggaac ttcgttaggt gaggctcctg tatggagata cgctgctgcc caaaaatgtc 1308001 caaagacgcc aatgggtcaa cagaaatcat cgacataagg tgatttttaa tgcagctgga 1308061 tgcttgtcct atgccataca gtgctaaagc tctacgattg aaggcgcccg cacgcttttt 1308121 ttgccgtgct tctttcacct tcaatcccga aggctttttt tatgccttta aaacgaaacc 1308181 aatcaaagga ggtgcggagt atggattctc cccattcgag tcaatctgaa gaagtaccca 1308241 tatactatga cagcaagaca attgattaca cgatgaggag acgaactgcc gcaccttctg 1308301 gcgaggccgg cacgtctccg tagaggaggt acgagtcccg atggttcaaa acatgaccta 1308361 tgacgaactc attttacgca tcattatttt actgcgagac gggaaaatca gggattttag 1308421 aagtgttatt gatgagcttc agccctatga catggcattt atttttaaag aaatgccgga 1308481 aaaacatcgc gcccgctatt tatcttattt aactgtagac gatatcactg atatgatcgg 1308541 ggagctggaa cgcgaatttc agcttgtcgt cttaaataaa gtcggaaaaa caaaagcaac 1308601 actggcgatg aacaaaatgg acaacgatga cctcgctcaa ttgcttgaag aaatggacga 1308661 agaactgaag gaacagcttt tatccagcat ggaagcgtca gaatcaaaag ctgtacagct 1308721 cttgatgaat tacccggctg attcagcggg acgcatgatg acaaaccggt atgtgtggat 1308781 ccctcagcat tacacggtaa aagacgcggt cgtcaaactg aaaagcttcg ctgaaatagc 1308841 tgaatcgatc aactacttat atgttattaa tgaaagcaaa cagctggttg gggttctttc 1308901 ctaccgcgat ttgattctgg gtgaacctga agaaaaggtg caggatttaa tgtttacccg 1308961 cgtcatatca gcagatgctc ttcaggacca ggaagaagtt gcccgcctga tagaacgtta 1309021 cgattttttg gcaataccgg ttgtagaaga aaacaacgtg cttgtcggca ttgtgacggt 1309081 tgatgatatt atcgacgttg ttattcggga agctgatgag gattacgaaa aatttgccgc 1309141 ttccggtaaa gacatcacct ttgacacaaa agcttacgtg gcggcatacc ggcgtctgcc 1309201 atggctgatt ttactcttat ttatcggact gatttcagga agcattatca gctattttga 1309261 agacgcgctg aagcaggttg tcgcgcttgc gtttttcatg ccgatggtgt cagggatgac 1309321 aggaaatacg ggaacacaat ctcttgcggt tgtcatcaga ggtttgtcta aagaagaaat 1309381 gaacaaaaaa acgattgtgc gcctgatctt ccgggagttc agaacaagca tttttatcgg 1309441 agcggtttgt tctgtgctga ttgcgattgt ttctatcata tggcagggga atgcgctttt 1309501 gggatttgtt gtcgcctctt cactgttctt aaccttaatc atcggcacga tgtcaggaac 1309561 gattatccct attattttgc acaaactgaa agtagacccg gcgattgctt ctggaccgct 1309621 gattacaacg ttaaacgata ttttatcttt attaatctac tttggcattg ccactgcatt 1309681 cattcactca ttataaacgt aaaaagtccg tctcaactgc gagccggact tttattattt 1309741 aacggttttt gtaccgaaag tgagcattaa gctgcccctc cagcattttt ttccgcactt 1309801 gcggatcgtt ttttaacatc tgttcttttt tgcgcatatc ctttaaaatc tctgccgtct 1309861 gtacgccgtc ttcacgctta ttggcgatat ccatcagccg ctccacatcg gcaaaggagt 1309921 attttcttgt cccccttgaa gaacgctgcg ggtaaatgag ctttcgttcc tcataatacc 1309981 tgatctgtct tacggacaat cctgtcaatt cactcacaat tccgattgaa atcacttttt 1310041 tgtctttata agaatgatct tctgtggtca tttttccacc cctggatgtc ttttgataat 1310101 agtatataaa aaacaaagag aaaaaacctg acgcttgtca tattttctaa catcaaatag 1310161 aagatttttg aaaaaatacg gaagaaaaat taacaagaat aatgcgtaac acccaagcgc 1310221 gttttatcct ttatgtaacg aatcaaacga ggaggaagga taatcatgga ggaagaaaaa 1310281 gcagtctcac tggcaaaaga aattatagag ttggatatca agcgtgatga aatgctggag 1310341 acgtttatgc agcttgccgg agaacaggct tttcaattat taagatcggt tcaaaacgga 1310401 caataccgaa aatcttcgta aacataaatt ctttacatta gattcatacc acgttcattt 1310461 aaaaagagta tcttttgtat aggatacctc aaaatgaagg aggacgctat gagtaattta 1310521 ttgaaatccg ctttagaaaa agaacgacgc cattattctg aaaaactcta tcagataggg 1310581 gtttataata aagaggtcat gaacaaaatg acgatttctg agcttcggaa agaatacgct 1310641 tatttctttc gaagcattac aaatcataaa aattatcctt atacaagata atgtataagg 1310701 atttttttgc ttttagaagg aatttctcga attatagcga atacgtatag taagggactg 1310761 aactcttatt atatgtaagg gttttcatta tttttttata aaaatcctat atacgaggta 1310821 gatatgatga gattatcgtt taacgaagaa gaagttgagc gtgcgatgaa tttgtacaga 1310881 gtttttgcaa gggctttcaa aagtgtgtcc gaacatagta tccgtgatag caaagagcac 1310941 ggttttaatc ccactgaatt tgctgtactg gaactcctgt acacaagagg cccgcaaaaa 1311001 ttacagcaaa ttgggtcgag acttctgctt gtaagcggaa acgtcacata tgttattgac 1311061 aaactagaaa gaaacgggtt tttagtaagg gagcaggacc cgaaagataa acgctctgtt 1311121 tacgcacatt taactgacaa gggaaatgag tatttggata aaatttatcc gattcatgca 1311181 ctgcgtattg cgagagcgtt ttcaggtctt tcgcctgatg aacaggacca gctgatcgtc 1311241 ctgctcaaga aagcaggcat acacagccag catttgctgt ttcgttaact attctacact 1311301 ctctatttca ggagagtgtt tttttgtttc catatgattc tttttaaaac atctttaatc 1311361 ttcctatcag acatttcgcc aaggtatcca ttgacgtgtt ttttatactc cttcatctgt 1311421 tcgttcgatt gaaaaaatgc cgcgatatac tcttctgctt tctgcatgtc ccagtttctc 1311481 atatctgtga cgagtttcct ttcatgtaga aggtttaaat tcatttcctc ctgtcccggc 1311541 agtgcatgat aaataaatac cggaagccgt ttctgtaagc attcactgat ggtcacgcct 1311601 ccgggtttag tcatgatgcc tgtcgcctgt tcgtacaaac ggttcatctc tgctttgctg 1311661 tgaaggtaag gaatcgcctc aatcaagggg tggtgtaaac ttttgacata ggagtagagc 1311721 ttttcgtttc tgccgcataa tattttgtat aagatctttc cgcctggcga cagttcctgc 1311781 acccatttta aaatcccacc gacccccata ctgccccctg tgatgatgat ggtatatggc 1311841 gggtggtgct gcaaggtatc tgctgattcc atttcaaaat tttggtgaac tggaatgccg 1311901 gtcaagtata tgttgttctg atcgataccc tctgatatta gctgcttctt tacttccgtg 1311961 ctcggaacaa aatggtaatc aatgttcttc cgtccccata attgattcac gaaaaaatca 1312021 gtgtatacat tcacaaccgt cagattcgga tattcaggct ttagtcggtt cagcagataa 1312081 gaaggcagcg catgtgtgca gaaggcgata tcaggctgtt tttcttggag gatgtgcctc 1312141 atttgctgtg tgaacagcca ttcgtacatg aaatagcgtt tgtcatgctg aaattctccg 1312201 caggcgagga gcctgtaaat gccgctgtac gttttcggga aatattgaat ccattttaaa 1312261 taagccacgg aggacaattt ttctaaccgc ctatacgaat gtgaaaagat atcaatcttt 1312321 tcagctgcca gcccttgaga ctctaattca gcctgcaatg catcagccac atgatgatgg 1312381 ccggtggaaa tgcttaaaaa aggaaaaatg agaatgtttt tcatgacagt cctcctaaaa 1312441 aaatatggca actatatttt gaggagaacg ttcacaaaat ataagggtgt ttttgatcat 1312501 aaggaaggtg aaaagatgaa aacttgtttc ctttccatat ggagagtggt tgatccgatt 1312561 tatttctttt tttcaaggct aagcttgatt gacaacgatc aaaaaagcgt ttttcgagtc 1312621 aggctgacga agtacaaagg acatcatgtc gtgcttagcg acggaacgca tataagaaaa 1312681 aatgatgtgc tcgttaaaat ccacctgcat aacataaagc tgatcaggga gctgcaaagc 1312741 attgagagcg cagtcagaaa gggaatcatt atttatcaga aagtatatca atcgatgccg 1312801 cttcttcttg actatatcaa caatcataaa aaaagcgaga aaatcaaagg aatcattggg 1312861 attacaatgc ttgacaaagg tgtggaaagg ctcggctttg atgtgatcac cccggtgaac 1312921 cctttttaca gatgctttaa aaaagtgtct catgtgccga ttttatattt gacttcaaag 1312981 cctgtgagct tgcggcattt accgaattca tcctatttgt ttatctcaaa agaaaagctg 1313041 cagaaaacct atcaaaaaaa agactgatgc ctcggtcagc acagtctttt ttgattaaat 1313101 ctgatgaaat gtcacttcag ggcggcttcc gacacggata tttacgccgg tttgtcccaa 1313161 gccctcgctg atataaaatg gtttatcgtg atgataatga aggcctttaa tcatgttcat 1313221 tcgcacgagc tttcccattt tcaccaaatg atacggtttt ggccagtgaa tttgcccgcc 1313281 gtgaaaatgc cctgacagca ggtaatcata atgaacatct ttcatatcca gaataatatt 1313341 tgggtcatgt gttaagacaa gatgatagcc attttccaga ctttgataag agccggtgat 1313401 attactccga ttcgtactgt aatcatcaat gccgataata ttgactggtc ctgcagccgt 1313461 ctcgattcga acatgttcat tttgcagcgt gatacagccg ttttcctcta aaactcgctt 1313521 caatctctga aagtcctctt ctttcaatac ataatcgtgg ttaccgaaca ccgcgtacat 1313581 tccatatgca ggctttagct tttgcaaggc gttcaagtaa cctgccagtt tcggaatatt 1313641 acgtttccga tcaagaaaat ccccggtaag agcaatgatg tccacaggct gatcttttgt 1313701 taaatgatac agctcctcag gtgagactga aatgttttcc aagtgaagat cagataaatg 1313761 aaggatattt aatttttttc tggctggaag gccgtctttt tggtcgattg aaatggtgtt 1313821 gactttcaca tcttttgtat tgcggttcgc tttatataga aatggcacaa atacgagtat 1313881 ggccaatgaa agtaagattg taaacaaaat atatcccctc ccttctatca gtatagtaag 1313941 tgatcaagcc ctatggatag cgggaattaa tgggtagaga caggttgaaa aacggattgt 1314001 catatgatga atgatttgga agggaaaagg gataataaat tttgacacat gaggcagaac 1314061 atgccgacgg agtcagaata acaaatggat gtgtaagcaa tgttacgatt gatgagacaa 1314121 caaaaaaaag aaacatatta tctctggatc gcattatttc ttcttttatt gtatgtatcc 1314181 ccgcttttta ttttaaagga agatgcccat atccgggtcc acgataattt agattccaac 1314241 atcgcttggt acaaggttct ggccgatagc ggagaaatcg tcggcaaggt tgacgctgcc 1314301 attccgcaaa tcattaacgg gctgccccgg gatgcctttg gcaccgagtg gagcggaatt 1314361 gtttggctcc atgctttctt ttcttccatg accgcctatg caataagcca gacggttaca 1314421 agagttgtcg ctttttttgg aatgtatgtg ctgctgaaga aacatataat cccggaacca 1314481 aaagcggctt tcatccgaat tggcgtatcg cttgcatttg ccttaacacc gttctggcct 1314541 tcgggaatgc tgagtacgct tgggtaccct ttggcactgt gggctttttt aaatatccga 1314601 aaaggggata tctcatggag agagtggctg acgctgggct tgctccctct atactcaagc 1314661 tttgttctag gcttcttctt tttcctggca gggatggcgt gtttttggct gtatgatgcc 1314721 attacaaaaa gaagatggaa tttgatgttc ttaggcagta ttgcatttat gacgagtatc 1314781 tatcttttcg ttgaatatcg gcttgtctat tcgatgctgt ttgagcacgc accgatgcat 1314841 cgtatcgaat ttatctcatc taggcatgac gtttggcatt ctcttcgact atccataaaa 1314901 aactttgtct atggccataa tcatgtgatg accgttcata ccgttgtcat ccttccgatc 1314961 ctgatggtcg tatttgctgc tctgctgttc aaacgaaatc ggacaaagcc agaaaatgtt 1315021 tatctgtttt tatgtgtgct taattacggg ttgtcattat ggtatgcgtt ttggttcaac 1315081 aaaatttggg ctgttccaaa gcagaaattt gcttttttag cagaatttaa ttttgcccgt 1315141 tttcattttc ttcggccgct tgttatatac gtgagctttg cgcttgcttt atatctcatt 1315201 tggcggatgg ggaaaggatg gaaatggctt gtgtacgccg cagtcgctgc acagctgatg 1315261 gtgttggcgc cttttaatga agaatatacg tatggtgttc attacaacgc gccgacattc 1315321 agggagtttt atgcatcaga gcaattcaaa gagattaagg aatatatcgg acgtccgcaa 1315381 gattcgtata gggtggcgag catcggactg catccgtcta tcgcccaata taacgggttt 1315441 tatacgttag atacgtataa caatctgtat ccgctctcat ataaatatga atttagaaaa 1315501 atcatcgaaa aagagctgga aaaaaattct cggctgaaac aatactttga tgaatggggc 1315561 agccgctgct acctttttgt cgatgaactc ggtaaacgat atgatttcaa aaagaactcg 1315621 aagaaaacga tcaacaacct tcaattaaat acagatgtat ttaaaaaaat gggtggacgg 1315681 tacatttttt cttcagttcc gatcatgaat gctgaacaaa accatctcgc gctcgtaaag 1315741 acgtttgacc ataaagattc cgcctggcgc atttatttat atgaaacaag ataaggagga 1315801 tatcgattga aacagtcaca gccagtatta accatcgtcg tcccgtgttt caatgaagag 1315861 gaagtgtttc aagaaacaag ccatcagctg acagaggttg tagatgattt aattgaagaa 1315921 aaattaattg ctgaagacag taaaattctg tttgtcgatg atggcagcaa agaccgcact 1315981 tgggctttga ttgctatgga gagcataaga aacaagaagg ttaccggctt aaaattagcc 1316041 tgcaatgtcg gccaccaaaa agcgctttta gccggattgc ataaagcgaa gaataggtca 1316101 gactgcgtca tttcgatcga tgctgatctt caggacgaca tctctgtgat ccgggatttt 1316161 atgctgaaat atcatgaggg ctgcgagatc gtttacggtg tacgccggag cagaaaaacc 1316221 gatacctttt tcaagcgcac gaccgcgtta gggttttatc gtctcatgaa taaacttggg 1316281 attaaattaa tttataatca tgctgatttt cgtttaatga ataaaaggtc ccttgaagag 1316341 cttgagcgtt atccggaagc gaatctgttt ttaagaggta ttgtccccat gatcggcttt 1316401 aaatcggccg aagttttgta tgaccgcaag gaacgctttg ccggcaaaac gaaatatccg 1316461 ctgaaaaaga tgctatcctt cgcttttaac gggattactt cattcagtgt cgcaccaatt 1316521 cgattcttta cgcttttagg gtttgttttg tttttcctca gcgctgtggc agggattggc 1316581 gcgtttattc aaaagctgct cggccatacg aatgcaggct gggcgtctct tatcatatcc 1316641 atttggtttt tgggcgggct gcaattgatg ggaattggaa tcatcggaga gtatattgga 1316701 acgatttttt ctgaagtgaa aagacggccg aaatacgcga ttgatattga tttgtataat 1316761 gaacagctga gcccgcttca gcgccaggaa aaagagcggt tagaaaaaaa gtacagttaa 1316821 acacggaaag agctgacttc attagtcagc tctttttctt caactgatgc aatatagcgc 1316881 taagcggttc gtcttgcggg ttgcggtaaa aatcaaaaaa tgggcagccc tgcttcttaa 1316941 ttcgatcgat gaccgtatca attgtaaaca gagcgggtgt taaagatgat tgcacctcat 1317001 gccagtagag cggggctgca acagtcccaa gctcatttcc tctcgttgaa tagggacaga 1317061 taatcgtttt tccttctgca tgctgcaaat aatcaagata caatttgcag tgtctgtttt 1317121 taatcaagcg ttcagtggta aagagctcgg gaaatgcatt ggtgcagtac tctgcgatca 1317181 gctgcgtaaa ttggcgtgtt tcttcatacg taaatgcctc gggagacaag ggaatataaa 1317241 gctggatgcc tttgttgccg gacagcttcg ggtacgatgt gatgccaaag gaatccaaca 1317301 gccgcttcag ttcatttgcg gcctgcacgg ccataagaaa gtcatctcgc gaaggcgggt 1317361 ctaaatcaat gacaatctca gccggacgcc tgcttttaat ggtttgaaaa ggaacgtgaa 1317421 actccaaagc aagctggttg caaagccata gcaatgtaga catatcctca cagacaatat 1317481 gttcatggct tccatcatag aaagactgaa caaaatccgg cgcatagtcc ggcttgtttt 1317541 tttggaaaaa tgattcgctc ctagatccat gcggatagcg gatgacggtg acagcccggt 1317601 ttttcagaaa tgggagcagg tagtcactga cttcaatcat atactgaata aaatcttctt 1317661 ttgttttttt attcttttca aatatgattt tatccaggct tgtgaactgg agctttgggt 1317721 gaaccggttt ggagtgtcgt atgacttgcg catacgtgca ttcggtccag tccatttgga 1317781 attcgaaacc gataaacgat acctctctta atgtgccttg gagaattgtt aagtattgaa 1317841 cagctgcaca aatcgaaggt tcaagcgtaa attcgcctga gggtgtttga tgtccgtgct 1317901 gttccataat ctcgcgtata gcgctttttt cctcatcacg cattccgtgc gagacagagg 1317961 caatcggtgt cattattccg ttttttaaca ccgataccgt cagaaacccg ttgttagggt 1318021 tgaaccctgt tatgcaaaca taagcttgtt taaagttttt atatttgagc caatcggacg 1318081 accgcttctt ttcaagccat ttgctgtttg ttttcttcgc tacaattcct tctccgtcat 1318141 attttattac catctcccag agttgatcaa aatgatcata acagggaatg gattgaatgg 1318201 tttcttttgc gtaaggatct ggagatgcag gaagctttgc tgcggatatg agttcacgca 1318261 gcgatttttt gcggtccaaa tacgaaagaa gcgttacatc ttctccgctt cgctctaaca 1318321 aatcaaaggc gagaaagcag cacggccgcg cgtttgccga ttcctgaatc ttgtctggcc 1318381 ttttcaaacg cccccgcact tgaaggtgtt caaaatctgc acgacaggga ttcaccaaac 1318441 atacgatttc accgtcaagt gtcagcggaa gctctttttc taggtgctga aaggcagttt 1318501 tggcgaattg tgtgatttca gggaaggtgc tgctgagctc cacaccattt ctgctggtta 1318561 aggtcacacc tgaagaatgg atgcggagaa tacagcggta cccatcatat tttacttcgt 1318621 aacgccattc tgctccgatt ggcggtgacg aagttaagac cggctgcatg gtaaacgcca 1318681 tgcgctatga tgtgccggag gctttttttc tagttgtttt ttgtttttta tctccggctc 1318741 ctttcggttc agcggcttgt gcaggtgcgg cagccggtgt ctcccggttc ggccttctgg 1318801 ttctgtcgat gctggcttgc agagcgctta ccaggtcaat gacatcttca cgaggtggcg 1318861 ctttatcagg agtgacagcc gtttctttat tttctagctt gtcgttgact ctttgcagca 1318921 gcgcctgtcg gtacgtgtct tcatatttct caggctcaaa cttagcagtc agttcatcta 1318981 ttaatgtgat agcagtttgc agttccttat cgtttacatt cgattgatca ggtacacctg 1319041 ggacttgagc ggcgcttctg acctcatcgg gataatggat agactccatg acgatacaat 1319101 tttcataaac gcggagaatc gccagctgct gctttgacct gattgtcata ttggcgatac 1319161 cgatctttcc ggttgagcgc agcgcctcac gcagcagggt ataggccttc gtcccattat 1319221 ccccggggcc gacaaagtag gagcggttaa aataaatcgg atcaatttcc tgaagctgaa 1319281 caaagtcaac aatctcaact gctttctcct catgctcctg ttttaagctt tttaaatctt 1319341 cgtctgtcag cactacatat tttcctttta catattcata tcccttcaca atttcatcag 1319401 gactaagagt tttttcgcaa tttgtgcaaa ctttctcgta tttgattggt gcgtgatcct 1319461 ctttatggag gctgcgcagt ttaatatctt tatcttctgt ggccgcatat agcttgatgg 1319521 ggatgtttac taatccgaag ctgatcgatc ccttccacat tgtatgcata tcgataaacc 1319581 cctttttttc tttagtgtga agagaaggag tacgattcat gtgtagtaac ttatgggtga 1319641 aaaaaagccg gcgctgttat tgcgacggct gttcaataat gaattgttcg aattgttccg 1319701 gaggtattgg cctgctgaaa aagaagccct gcaaatggtc gcagcctttt tcaaaaagaa 1319761 gctgcttttg agctgcattt tccacacctt cggcaatcac ctgcaaagac agctgatgcc 1319821 ccatggcaat aatagctccg gtaatttgct ctgatttagg atgggtctga atatcgtcaa 1319881 taaatgattt gtcaatcttc agcctgtgaa tcgggaagtc cttcaaatag ctaagagagc 1319941 tgtgaccagt accgaaatcg tcaatactga ttctgattcc taattctgtt agggatgaca 1320001 aaaccttttt ggagtgattg agattgtcca ttgtcatgct ttccgtcacc tccacttcaa 1320061 gaagctgcgg aggaagctgg tacttattaa gcgtatcctt gatgagggga atcagatctt 1320121 tagattgaaa ctgtctggcg gaaatattaa tggcgacaga aagatcatag cctttgtcat 1320181 gccaaatcct tgcctgcttg catgcttcat ctataatcca ctttccgata tcaataataa 1320241 gtcccgtttc ttctgcaaca ccgatgaatt ctccgggcgg acgcagttgc ccgtctggtg 1320301 tcacaaggcg tatcagtgct tctgctcctg tcattttttg ttttttcaca ctgaattgcg 1320361 gctgataatg caagacaaat ctatcgtttt cgattgcttc tctgagtacc atctcttggt 1320421 taagcttaac ggtttctttg ttgccgattg aaaaagaata gtatctgtat ttgcttttgt 1320481 ttcgttcttt agccgcatac atcgccatat cagccttttt catcaattca aggccatccg 1320541 tcccgtcttt tggagatatc gcaatcccga tactgacaga tgtgacaagg gtgtgatctt 1320601 gaattttgaa aggttttttg aatttttgga taatttttct tgctaaaaca tctgcttcgc 1320661 ctgttcctgt attggcgtct gttaatataa taataaattc atcaccgcca agacgggcga 1320721 taaatccgtt atcagggact acagatgaca ggcgtttagc tgcaaactga agcaattgat 1320781 caccgacatt atgccctaat gcatcgttaa tcactttaaa ccggtttaag tcaagaaaga 1320841 atacaacagt gttataatgc aaggaatgct cgcgattcag cacctttgtt agatgagaga 1320901 tggcatgcct tctgttaggt aagtctgtaa gcgaatcata atgagccatt ctatggattt 1320961 ctttttctgc tttgtactgc ttcgtcatgt ctttacaaat gacataaatg ctgtctagtt 1321021 cctgattgac ctcaacaggt ataagcgtaa tatttaagtg aaactggcct ttttcagtga 1321081 taagatcgct atcgctgttc atcgcttgtt tatctttttt aacttgctca aaaaggcgct 1321141 taaccttcag tgatgtgtaa ttcctccagt catgcatgct gaagccaaat ttgctgatca 1321201 tttcctcacc agcgtgattg gaagatatta tgtctccttc taatgataaa ataaaaattg 1321261 catcaatatt gtggacgatt aaagactgaa atcgctgttc gttatccttt atgcgttcgc 1321321 tctgtttaat aaactttcga tctgcatggg aactgaataa caataacgtt tggatacaaa 1321381 aaataattaa agtaacaaaa attgaccaat gaaacgtttg cacctccata tggcttccgg 1321441 gcggagccat gtccttatgg aaagttgccg caagcatccc tgtgtagtgc atgcccgaaa 1321501 tcccaatgcc cattacaatt gaactgacgc ctttatagaa tataagatgc tcagaatgtt 1321561 tttttacggc caagtcaaag aatattttta acgagacgaa agaggctgca atcgcaatga 1321621 taattgaaac tgtaaataaa ataggttcgt aaataatcat tacccgggaa atggcagaca 1321681 ttccgatata gtgcatagaa gcaatagatg cgccaagcac aactgatccg gtaagcagtc 1321741 tgtaatatgt aagaatgtgc cggctgacaa aatataatga cacaaatgat cccgaaacag 1321801 atgcgccaat ggctgccatt aaaggcatga attcatattc catcggcatt tccatatgga 1321861 cggccatcat ccctacaaaa tgcattgacc aaataccgaa tcccataata agtgagccgc 1321921 cgatcagcca aattttactt tttaagcctg tattgatggt gactttcctt gaaagttcaa 1321981 gggaaatata cgaggcggta caggcaatta gaatagataa acatatgaga gtcgtattat 1322041 atgtaacgtg tatttccaaa tggagattcc ccccgtatcg tgtgttccag tcttgttgac 1322101 tctctttatt atcggctgct taaccgcaga gtttcagcct tcaaaacgat agaaatacga 1322161 gggagatcta tttttagttc aactgaccgt gaaaaatgtg ttaaaatcat cttgatgttt 1322221 tccgaaaaga gaaaaatgta tgatacataa acatgaaaca agggagttgg tggctatcga 1322281 agagctggtt atgtcatgga ttgaagcatt taaaagctta tcttattttg gaatatttct 1322341 agcgctcagc attgagttta ttccggccga agtcgtcttg ccgcttgcgg gctattgggt 1322401 atctaaaggc gatatgacac ttgctggcgt tgttttggca ggatcgcttg gaggagtggc 1322461 cggtccgctt acgctgtatt ggataggccg gtacggagga aggccgtttc ttgaacgttt 1322521 tgggaagtat ctctttatta aacctgaagc gcttgataag tcagataatt ttttcaaaaa 1322581 acatgggggc tttgtcgcct tcagcggccg tttcttgcct ggtatcagga cattgatttc 1322641 cataccgtgc ggaattgcaa aaatgaatgt ttgggtgttt tcgctttata cattcattgc 1322701 tatgcttccg attacatttg tatatgttta tctcggtgtg aagctcggtg aaaattggaa 1322761 ggcagtcggc tctattcttg atcaatatat gcttccgatc gggatagcga ttttggcgct 1322821 gttcctgctc tacttactga tgaaaaagag gaagaaacgc acgcactccg aacaattatc 1322881 tgtatttttg aaaaataaac gttgacaaat cactgcgctg cgcatattat tgacgtataa 1322941 aatcatattt cttgaaatcc caaaggggag tagcgtccgg aatgtattcc ggaaacaaag 1323001 tcgtcatttc atggattgta tccatcggct ttgttggcat gcctgaattc atgtctagca 1323061 agacctttgc cttatgtcgg caaaggtctt ttttgcatgg tccggccggc ataagatcgg 1323121 atgaagagaa agaaaacaac ttttttggga gggtatcatt tatggatgca gcattattat 1323181 tagagtatgg ttgggttctt ctcgtcttga tcgggctgga agggatttta gccgccgata 1323241 acgcgctggt tatggcggta atggtaaaac atttgccgga ggaaaaaaga aaaaaagcgt 1323301 tattttatgg attggcaggg gcttttgttc tgcgatttgg ctctttattt gcaatttctt 1323361 tcttggtcaa cgtatggcag gttcaagcga ttggcgcgat ctatttgctg tatatctcag 1323421 caagccactt attgaaaaga tatgtattta agaaagaaga cacacataaa gagacgaagc 1323481 aaagcggttt ttggccgact gttttaaaag ttgaactggc agatatcgcg tttgctgttg 1323541 attccatctt agcagcagta gcgctggcgg ttacacttcc tgggacatca ctcccgaaga 1323601 tcggcggact tgacggagga caatttctcg tcattttggc cggcggtatc atcggactgg 1323661 tgatcatgcg gtttgcggct tccatgtttg tgaagttatt aaaggaacgt ccaagcctag 1323721 aaacagcagc ctttgtgatt gtcggctggg tcggagtgaa gcttgcttta tatacgcttg 1323781 cccatcgcga catagcggtt gtttctgagc actttatcca ttctggaaca tggaagctga 1323841 tattctgggg tgtcttagca gcaatcgcgg tttgcggctg gtttatgtca ggtgggaaaa 1323901 aacagccgga gggtgcacaa aacgaacaaa aaaacagcac ccgtgaacgg gcgtaatctg 1323961 aaagactctg cttaaaagca gagtcttttt gtgtttgaag cgttttcata agcgaaataa 1324021 aataacattt ttataacatc tttgttacaa aaaacacgca taaaaccccc ttaattcttt 1324081 agaaaggcac gaaatcatgt atagaacgtc agaatggttt gtcataattg agacattgga 1324141 aatcaatatt tctttttctc ctttgcgaat ccctatcaaa ttagctatca ttaatgagta 1324201 gttataggga ggaactgagg tgaaaccagt gcttagcctt ttgtttaaat tgggaaaaaa 1324261 gaagcaaaca cttgaaaaag ctgttgagag tatacaaaaa ggcaataaag atctgcaaaa 1324321 tgaattaata cagcaatata agccatttat cgcaaagacg gtttcatccg tttgtaaacg 1324381 atatatagat gaaaaagacg atgagttcag tattggactg atcgcgttta atgaagctat 1324441 agaaaaatat tcacctgaaa aaggaaattc tctgctcgca tttgctgagc ttattataaa 1324501 aagaaaagtc attgattaca ttagaaaaga agccagaagc gcacaaaata taaatatcga 1324561 tttacaggaa ggagacgatc aggagtcatc acaaagcctg attgaagccg agctttccat 1324621 tgatgaatac cgccgtcaga ttgaacagga gcagaggcgg gaggaaatcc tctattttca 1324681 aaagcagctc aaggattatg gtttatcgtt taaagaactg cttgaaaatt ctccaaaaca 1324741 cacggatgca aggcaaaacg ccataaaggt ggcaatgacg cttgttgaac atgaagaatt 1324801 ggccgctatc ctgtatacaa agaagcagct tccggtcaaa cagcttgaac agcttgtctc 1324861 tgtaagccga aaaacgattg agagaaacag aaaatatatt attgcgatgt gtattatcat 1324921 tacgggtgat tatatttatt taaaagatta tcttaaaggg gtgctgcact catgagaaga 1324981 gggattatag tagagaaaaa taaaaaattc gtcacgttgc tgacccctga cggacaattt 1325041 ttaaaagcca aaaatgatcg acacagctat gaaatcggag aagaaatcat gcttccgagt 1325101 gaaacacgca tgggcagaag ggccagcttt tttgattttt ttaaactgcg ccctttcaaa 1325161 atggggattt ttacgatgac tgctattatg ctctttattt ttatagttct ccccgttttt 1325221 tctaataata aggcctatgc gtatatgaca atcgatatca atccaagcgt cgaaatggcg 1325281 ttaaacagcg attatgaagt gattgaactg acgcctctaa acgatgaggg acagaaagtc 1325341 gtgaatgata tagatgattg ggagaagact gattttaaaa aggtgattga cgatattata 1325401 accgactgca gtgaacacgg gtatgtaaaa aaatcgaaag aaatattgat ttccactgtt 1325461 tatgaaaaca cagaagacaa tacatataaa aaggctgtga aaaaacagct gaatgatgtg 1325521 actgaaaaat ataaaacgac ataccgcatg gaatctctcg agtcagatat gcaaacgagg 1325581 gaaaaagcga agaaagaagg cgtctcaaca ggcagctaca tcaaatcaaa tgaaaagaat 1325641 gacaataaag atataaaaga tgactccagc aaaccatccg gggaagagga tcaaaagagt 1325701 gatgaaaatg aggatgaaaa caccgatcaa actgacaccc aggacagcaa gcaaggagat 1325761 aatgaacagc tgaatgatgc ggattccgga gaccagaaag aagagaaagc ggatgaccag 1325821 attgatgata gtgacaaaga taaaaaaata aaggaatcag atgaaaacac aaataccgaa 1325881 aaagatgggg accatgagca aaccccaata caagatcctc aagataaagg aaatgaaaat 1325941 aacggcgctg acaagggcca aagccaatat cacagggact ggaacaatgg tgaacaaggc 1326001 aagaaccgtt cttcgtccag aagggataac gcttcagacc gacgtaatcc aaacggctac 1326061 agcagtgata atcattcagc taaaaatgaa gattcgccga gtgcccccgg cgaataaaga 1326121 cctgaattta tttagttgtg ccatttaatt gtgattgtgc ttgctgtacc agccgctttg 1326181 tcatttctcc gcctacagag ccgttagcgc gtgcgactgt atcagaacca aggttcacac 1326241 cgaattcttg agccacttcg agtttaaatt ggtctagtgc ctgctccacc cctggaacaa 1326301 cgagtttatt tctgctcgcc atctttttca tctccttttt cgataaagaa attcttaacg 1326361 cgtatttagt ttgaaatata cggggtttat ttatgctggc aattgttgtg gagaaaaata 1326421 aaaccccggc ctctgagccg gggtggcgca gactatagaa tgtctgctgt cattttatgt 1326481 gcggttgcct gaatatggaa tgtcaaaatg gagaggactg taatggcgat aatctgtctg 1326541 attttaagcc attggctgtc attcagttct tcaaaacggt gacggagacg ctctgtctcc 1326601 tgttcggcga tctcctgcag atttgattct ttcatagaag gagtatcttg gtgatggatg 1326661 gcatcaagca catatgcgca gctttcataa taagcaatcg ggctgatgac atcatcagat 1326721 ctgtctgaga ttgtgttaaa ggccactttt aaaatagccc gtatgtgttc aaagtcataa 1326781 atggatttta aatcacgtac aattaaaaga ataactgcct gttcaattga gtattttttg 1326841 cccagctcag ggtgtccgat cagatctttg atatcacgct ttacccagtt ttgaatcgcg 1326901 gttgacttta acgaagtcag ctcgcataag ttgccaagct ctacgatttc atttgtagac 1326961 agaccgtatt cttttttctg tttttttcgt tcgtatcttg taagaaattc aggaatttct 1327021 agatgattgg ctgctttttc tgctgacatg ttcgctgatt ggacgagaat gtcgagcggg 1327081 ctatgttctc cttgtccttt tagggaatag agcagccgca ccatatcggt tcgagagagt 1327141 ttaaaaatgt tcattgttca cctctttaaa caatttgacg cggatatagg tctatgtata 1327201 agttcaaaat tcaagcgtca gcaaattaca ttaacatcat acgtcgaatt ccttgcattt 1327261 tcaaatggat gttttataat ttaaatatac gggttctttt gaacttaaaa taacggaggt 1327321 tgttatggcg aaaagaattt ttctgtttat tctaacgaat attttggtgc ttacaacaat 1327381 cgggatcgtt ttgtctgttt taagctctgt tacaggagtc gggacgtact ttacagctga 1327441 tggcggtatc gatccaatgg cgcttcttgt gttcagttta gtcgttggat ttgtcggttc 1327501 ctttacgtct cttgcgatat ccagatggat ggcaaagacg atgatgggcg tcagagtgct 1327561 gaatccgaaa aaacactcgc tcagctatga ggaacagcaa ttggttgatc gtgttcacag 1327621 attaagccgc tctgccggtt taacgaaaat gccggaagtc gggatttacc gttcacctga 1327681 agtaaacgcg tttgcgactg gaccgtcaaa acgccgttca cttgtcgcag tatcgtcagg 1327741 gctgctggag cagatggatg acgcagcagt tgaaggtgtg cttgcccacg aggtcgcgca 1327801 tatcacaaat ggtgatatgg taacaatgac gcttttacaa ggtatcgtta atacctttgt 1327861 cgtcttttta tcgcgtatcg ccgcttggat agcaagccgt tttgtcaaag aagatctagc 1327921 gccgatcgtt cattttattg caatgattat ttttcagatt gtcttttcga tacttggcag 1327981 cctggttgtg tttgcgtatt cacgccatcg tgaattccat gctgacaggg gaggagcgga 1328041 tcttgccggc aaggacaaga tgattcatgc gctgcggacg cttaaaagct attcttcccg 1328101 gattttggaa gacgatcaga cagctgtcca aacgttaaag attaatggca agaagcgctc 1328161 ttcacttttc tctactcatc ctgatttaga tgagcgaatc agacggctgg aagctaaata 1328221 atacaaacac attgttcctc tgagagaatt ctcagaggtt ttttatttta tccattgact 1328281 aaaatcataa aaaaataagc aagttaagaa aatgtttcgt aaaagccttt aaaaatggac 1328341 ctaatatctt tagaataatt accgtactta aaaagagagg cagaaggatt ttacatgaga 1328401 ttaaagtttg gaaaattgat acaggccttg tcaccggccc agctgatcgc attatattat 1328461 tttcttgcag ttactgtggc cgttatattg ctgagtttgc cggcggccca taaaccgggg 1328521 gcggattgga cgtttattga tgcgcttttt acagctgtca gttcagtcag tgtaacgggg 1328581 ctgacagttg ttgatacagc tgatacattc agcacaatag ggatttttat attagcattt 1328641 gttctgcaat ttggcggaat cggaattatg acgctcggaa cgttcatttg gctgatcatg 1328701 ggaaaacgaa tcgggctgaa agaacggaag ctgattatgg ttgatcaaaa ccaatcccag 1328761 ttttcaggaa ttgtcaatct gatgaagcag gtactgtttc tgatcttgtg gattgaattt 1328821 tttggcgggc tgatactcgg cacatatttc ttaacctact atgactccta tcaggaagcc 1328881 tatttacacg gattttttgc cagtatcagt gcaacgacaa acggcggatt tgatattacc 1328941 ggtaattcga tgattccatt tcgccacgat tactttgtgc agtttattac aatgctttta 1329001 attatatttg gagcgattgg atttcccgtg cttgttgaag taaaggattt cctgttttca 1329061 aagcatcggc gttatccatt tacgcttttt acaaagatca cgacgattac gttcggctca 1329121 cttgtcttgt ttggagccat tggcatcttt gccctggaag caaaccatgc gttcgcagga 1329181 aaatcatggc atgatatttt gtttttgtcc ctgtttcaat caacggcaac ccgaagcggg 1329241 gggctggcaa caatcgatat cagccaatta tcagattcca cactcttttt tatttgtgcg 1329301 ctgatgttta ttggagcgtc gccaagctca gtcgggggag gcataaggac aacgactttt 1329361 gctttgaacc ttcttgcgct gtttcatttt gcccgcggca ataaggccgt aaaggtattc 1329421 aaacgggagc ttcaccctgc tgacttgatg aagtcgcttg ttgtcacgat gatggcgatc 1329481 ctgctcgttt ttggcgcgac actcattctg accattacag aaaaacattc cctgctggag 1329541 cttttgtttg aagtgtgctc ggcattcggt acaaccggcc tatcgcttgg aattacggca 1329601 gatttgagca gtgttggaaa atgcgtcatt atgattgtca tgtttatcgg gcgaatcggc 1329661 atcttgacct tcctgtatct gatcggaaga aaggaaattg aagcgaatta tcactatccg 1329721 aaggaaagag tgattatcgg ataggcaaaa caccgcatat tttgcggtgt tttttgatta 1329781 ccaaaaaaaa gatgtgtgcc tcctgttcag ttggagaacc taactccgac aggtgcaatt 1329841 tacgctcctg catcttaaaa tgtctgaaaa ttggcgagga ggattcgtat gaagcgtaaa 1329901 gctgaagtga atgaagccat taaaaataac aatacaccta ccgagagcat ggaccccaat 1329961 tcatataaga cacaatatca tgacgacccc aattttagag gggcaaaccg caattccaaa 1330021 cagggccagc agggaggcat gtaattgtga agaaaaaccg tcatagcaga gacatgcaaa 1330081 atcataaaaa gcctatgaat aaaaaggtgc tggaggaaga attctcaagt gaactcgggg 1330141 attacaatgc cggaaagatc atcgaaacgc tggaagtcac caagcctgaa aagaaaaaag 1330201 aaaaaaacaa aaaacaacaa taaaaaagac ctcttaggcg gcgtcccgct taagaggtgc 1330261 tttttctatt ttaaataagc atttttgccc gttcctctga caaattgcaa taagcttgtc 1330321 atcctcagct caatgaatgg ctgagcgact gtcttaacaa agttgctgga gaggactgat 1330381 gtcagggctg ctgttaaaag caagaggatc actaagcttt gatagtcagt aagccaatcc 1330441 tcaagcccga cctgccgtaa tgtcttaata ataaacccgt gaagcagata cacgtaaaat 1330501 gtccgggttc cccatttggt aaagaaatac cgtttttgcg gaacgagcgc taaaaagctg 1330561 aaggttgccc caaaggcgag tacataccag ccgattcggg atagtccgct taccagggta 1330621 acgtctccaa atgaagaata cggttttgaa ccaaacagaa aagaatagtc aaaatcgatg 1330681 ccccagcaga tgacgaatac tgcggcaagc actccgagcg caatttgttt gccgcgtttt 1330741 gatctcaata aatcaaaatg atgtttattt aaataaaaac cgacaaggaa catcggtaag 1330801 aatacgaatg tccgtgacaa gctcagcgtg ctgctgacaa agtccagata accgatcagc 1330861 acggcgattc cgcagctgac aaacagcgcc cactgctttg aaagctttga aaaaggatat 1330921 aggagcaggt tccaaaagaa taagcttaca agaaaccata acgaccattg cggatcaatc 1330981 gggttcacat ttgccatgct ttcatcttgc ataatgtaat aaaagacgga ataaataatt 1331041 tggaaaatca aatacggaat aatcagcttg accgccagct tttttacata tcccgcccgt 1331101 ttaaagcctt tcgcgaaata accggataca agaataaatg caggcatatg gaatgtgtaa 1331161 atgaacttgt agaggtagag cataaaatga ttatcattaa taaaggaacg aaggatatga 1331221 ccgaatacaa caaggaatat caataaaaat tttgcgttat cgaaataact gtcccgcgat 1331281 ttactcatag catcaccttc tctttcatca gtcactaaga gattattccc tgctggtaca 1331341 tattttaaaa taaaagatga aaaaggaatc taaaaaaatg ctgattgtta ggtcgatgta 1331401 aagtgacggt aaggatcgta gaaaatgtct tcgtaatgta atgacgctga aattttctga 1331461 aatttatagg gcaaatgaag gaagttcccg cattttgtag aaatattgag ggataggttt 1331521 tgaagaagga gtgtacatgc atggaaactc ttggtgtcca gacaaactcg gagctgcgag 1331581 aggaactgaa tcgcctcaaa gaagaaaacg cgcgactgaa aaaggaattg aatcagcatc 1331641 aagtgattgt caacaatacg ctcgatgcta tttttatttg tgataacgaa atgcggattg 1331701 ttcaggcaaa tgaagcaaca gaaaggatgc ttcaagttga ctcggaagat ttgaaaaagc 1331761 gttctgtttt ggattttttg ttttcaatcc caaaggatga actgaatctt tccgtaaaga 1331821 agttttttaa aaaaggcttt ctgtggaagg aggttccgat caggcttgat tgcggggcaa 1331881 caaaatacat agagtttctg gccaaaagag gtattggtga ggatttcttt tttgttgtca 1331941 tgagggacat atcttctaag aagattctgg agcgggaatt ctctatgaat gaacagcttt 1332001 ttaaggactt gtttgacaga gcagttgacg gaatcgtcct gtttgataaa gatggcggtt 1332061 ttattgatgc aaatttgtcc ttttgtaaaa gctttgaaat caatcataat gagctgtctc 1332121 atttatcttt gtatgagttc atagacagcg gctcacgaaa agatttcgac aatatctgga 1332181 aggcgctcaa ccgcaaggga aaagcgaagg gggagctgcc tgtcaagctt cgttcaggag 1332241 ttcaaaaact atttgaattc acgattacat caaacatcat cagcggtttt tatatgtcca 1332301 ttatgaggga tatcacagag aagcggtcta tggagctgca gctctttaaa agtgaggagc 1332361 gcttcagaga aatctttgaa aatgcaatgg acgccatcat catctggtcg aatgacggaa 1332421 gaatcgtaaa agcgaatcaa tcagcctgta aaatttttga gctgccgatg aatttgctgt 1332481 tgaaaagaaa gctgtgtgat tttctcgttg actcgcagca gaaatacagc ataacgaaga 1332541 ggaaatacgc aaaatacgga gagatcagag aagagctgct gtttcaaatg gggaacggcc 1332601 aattcaaaga gcttgaattt acttcaaaac ggacaatcct tgaaaatcag catttgacga 1332661 tcttaagaaa tgtaagcgac agaaagcgga tggaaaagga gcttcgggaa agcgagctga 1332721 aattcagaaa agtgttcaac ggatcaatgg acggcaatgt attgttcgac aatcaataca 1332781 ggatcatcga cgccaacccg ttagcaagcc atattttggg cctgtcacat gaagagatca 1332841 aacagcacag cctgttagat attatttctg cttatgaaat agaaaatttg gcatcaccgg 1332901 caaggcagat taattttgat gaaatggaca acgaaattcc atttttgctg agcagcggtg 1332961 ataacagaaa actcgaattc tcatttaaac ggaatattat tcaaaatatg aacttggcta 1333021 tctttaaaga cgtaacagag cgaaaagaat tggaggagcg cctgcgcaaa tcagataccc 1333081 ttcatgttgt cggcgaactc gcagccggta ttgctcatga aatcagaaat ccgatgactg 1333141 ctcttaaagg cttcattcag cttctgaaag ggagtgtcga gggagactac gccctttact 1333201 tcaacgtgat cacctcagaa ctaaagcgca tcgaatccat catcaccgaa ttcttgattt 1333261 tagccaagcc ccaggccatt atgtatgagg aaaaacatgt tacccaaatt atgagggaca 1333321 cgatagacct tctaaatgcg caagccaatc tcagcaatgt acaaatgcaa cttgatttaa 1333381 ttgacgacat tcccccgatt tactgtgaac cgaatcagct gaaacaggtt tttatcaata 1333441 tattaaaaaa cgccatcgaa gtgatgcctg acggcggaaa tatttttgta acgataaagg 1333501 cattggatca agatcatgtt ctaatctcct taaaagacga gggaatcgga atgacagaag 1333561 ataaattaaa gcgacttggt gaaccgtttt atacgacaaa ggaacgggga actggacttg 1333621 ggcttatggt aagctataaa attattgaag aacatcaagg cgagattatg gtagaaagtg 1333681 aagaagggaa gggcaccgtt ttccatatta cgcttcctgt cagacagaat gctgaagaaa 1333741 gaaggaatga tgaatgaact actatacgac agccgaaacg ccgctcggtg aacttatcat 1333801 tgccgaagag gaggaccgga tcactcgtct atttctcagt caggaagatt gggtggattg 1333861 gaaagaaacg gttcagaata ctgagcataa ggaaacacct aatcttgcag aagcgaaaca 1333921 acagcttcaa gaatatttcg caggcgaaag gaagacattc tccctgccgc tcagccaaaa 1333981 gggcactcct tttcagcaaa aagtgtggca agcgctggag aggattccat atggcgaatc 1334041 ccgaagctat gcggatattg ccgctgctgt cggcagtccg aaagcggtgc gcgctgtcgg 1334101 gcaggctaat aaacgtaacg acctgccgat ttttgtcccg tgccacagag tgatcggcaa 1334161 aaacagtgcg ttaacaggat acgccggaag caaaacggag atcaaagcat ttttgctaaa 1334221 catcgagcga atctcctata aagaaaaata aaacatatgg cacgttccct tttttcacgg 1334281 ccgacatatc attttattaa gttaaaaaag ttggtctgat gaaaaaggag gacaaagcaa 1334341 ttgaagccga gccgctctga gaaacttgcc gtttttgccg aactgtttgt gaaactgcat 1334401 atcttatcaa gcgctcaaaa agatgaaatc atcaatgtta acaaaaagaa acaaaaaaac 1334461 cgctgactcg gctccaaatg agcaaagtcc agcggttttt taatgcacct tttctccttt 1334521 aaacagctgt tcaatctctt cttcatagtt tccggtcata atcccttttt ctgtgatgat 1334581 tcctgaaatg agatcatgag gtgtaatgtc gaaagcggga ttaaagacag gcacattgga 1334641 tggagcggtc cgaactccgg aaatctgcct gacttcctcg ggatctcgtt cctctatcgg 1334701 gatatcagcg ccgcatttga cctttgtatc aaatgtagat aaaggtgcgg cgacaaaaaa 1334761 cggaatatca aaggcgtttg ctaaaatagc aagaccgtat gtgccgattt tatttgccgt 1334821 atcaccgttc tttgcaattc ggtcggctcc gacgataaca gcggaaattt gtttttcctt 1334881 catcgtatgg gcggccatgc tgtctgtgat cagagtgaca tcaatgcccc cctgcatcag 1334941 ctcccaagca gtaaggcgtg aaccttgcag gacaggcctt gtttcacagg cataaatgtg 1335001 taatcccaaa tctttttgtt tggccaagta aaacggagct agcgccgttc catagcggct 1335061 tgtcgcgatt gagccggcat tgcagatcgt catgatcctg tcgccttttt tgaaaagctg 1335121 cagggcgttt tggccgatca accggcacgt ttcctcatcc tcgacctgaa tctgaatggc 1335181 ttcatggaca aggtttgttt ttgcttcatt tacggaaatc gcgttttcga ccgaatgact 1335241 cagtctctca agcgcccatg acaaattaat ggcggtaggc cgtgagctgt ttaaatattg 1335301 tttgatgtct tccagtctgc ggcggaattc cgtgacattg tctgtttcaa tgtctttggc 1335361 agcaagcgcc agtccgaagg cagctgtaat gccgatcgcc ggagcgcccc ttactttgag 1335421 cgtgacaatc gcatcaaata catcctcttt cgtcgtcagc tccaaatatt ccgtctcatc 1335481 aggaagcttt tgctgattta aaatggtaat agctgtttct ttccattcaa cagaacgtgg 1335541 aacagcaaat gaatgggtca tgaatagatc attcctttac aagtaactta aataattcaa 1335601 taacatctgt tatcgttttg aattccgaac gtttttcgat aaaggctgtg ccggtttcga 1335661 gcgccaagcg ttttctgccg attcgtttat caaacggcac gatcgtatcc aggtcagcta 1335721 catgggcaag gccgatcgtg cgtcgtatca gctcacagcc cgcaaatccg attgcttctt 1335781 caaaaatatg gctgagcgta tcagtgaggt aaccgtcgat gttggcgtaa acatccagac 1335841 tgtccttctg ccaggcttca ctaaacgtct cttcaaacgt ttcccagacc tggttgacat 1335901 gttcatataa cggctctctg tcagccccgt cacggctgag tgcgttcaaa aataagttgg 1335961 cgataaattg ccctacatca aagccgatcg gtccgtaaaa agcaaactca ggatcaatca 1336021 cctttgtttc gtgctcactt gcgaaaatgc ttcctgtatg caaatcacca tgaatcaacg 1336081 tttctgcaga cgttaaaaat gactttttca gcttagcggc ttcgatttta acgctgtcat 1336141 tattccaaag cttttcgaca aaaggacgaa gctcttcttc aaaatcattt gtgtcatggt 1336201 cgaagaaagg atctgtaaaa acaagtcttt ccgtaatgtc gcatagctct ggatttgtaa 1336261 actgtttaac aagctgtttt ttcaccttag gttcaagcgc gtaatctgat gagtagaaaa 1336321 gtgtttttcc taaaaattca ccgatgtgct gcgacagatg aggatagttt tcaccctcaa 1336381 tgagtccttt tcttgcgatc ttgaggtgag agagatcctc catgacggta accgccattt 1336441 ccgtatcaga ataaaacact cttggaacca ggtgaggcac atgctcgccc tgacggatga 1336501 gagcgctgct ttcgattctt gcacggtcga ttgtcagcgg ccagctttct cccaccactt 1336561 ttgcatacgg aaccgcctgt ttaatgatca atgctctgtc atgttcttga tcataaatat 1336621 gaaaaacgta atttaagttg ccgtctccga tctcctggca tgtcagcgtg cttttgcttg 1336681 gaaataggcc aagcttcacc gccaacgcca cagcggagct ttcatttaac gtttcgtata 1336741 aaggtgtttt tgtgactccc atcatcataa cctccaatta tgtaattaat taatatgtgg 1336801 ccgtaaaaaa gcctccttct cagagagaag gaggcttaac atctatgtcc gcctctctta 1336861 tctctcagat cagatctgaa tggaattagc accgtgcctt aagagaccag cgtctcggcg 1336921 cgaaaaaaat gcgccccatt tcacaatgga attacggtcg gttgcttttg gggtcaaaag 1336981 gccaaatccc tcgcccaact ctcgataaga gaatatattc acttgtttga caattctaat 1337041 ttatcagttg atgaacatgg taacaggtaa tttagttagt tgtcaatata ttttttaata 1337101 taaatctttt ctgatatcat cgaaaacagg aatgctctcc cgaacttctg cgctttcttg 1337161 aaggtcgatt tccgctcgga ctatgccttc ttcccggccg ccttcagcaa gtacacgtcc 1337221 ccatggatca ataatcaggc tatgtcctgc aaattcatta tccggatttg aaccggtaca 1337281 attgcaggct gcgacaaagc attggttttc aatggcccgc gcaataagca ggcttttcca 1337341 atgatcaagg cggggaagag gccattccgc agaaataaac agcacgttgg cgccttttgt 1337401 cgtatgtttt ctgatccatt ccggaaaacg gatatcgtaa cagatcaatc cagagctttt 1337461 gacgccgtca agctcaaagt atccgtcttc ggaaccggct gataaataca gatgctcatc 1337521 catcagctga aaaagatggg cttttctgta ctctttaatg atttgccctt ccttatccgc 1337581 gatgtacatt gtattataaa catcagaatt cttcctgaca gcgaccgatc cggcgacaat 1337641 atgaacacca tgtttttttg ccgttttctt cagccagctc tgagcggagc ggccgtcttc 1337701 gtcagcgagt tcatcaagat tggccagatc atatccggtc gtccataatt caggcagaac 1337761 aagaacatca gcatgtttgc tttctttttc gatgaaaaat tcagcctttt ttatattttc 1337821 cgaaggtttt ccgtatgaaa tatcaaattg aagacaagat atcgtccatt tcatcttttt 1337881 aacaccccaa atttttcttt acttttttca tttaaccata tatgatgatg gactatcatt 1337941 tcaagatttt tttagaaggt gagaatagat gaaatttgaa cagtctcatg tattgaagga 1338001 attgcctaaa caattcttcg cttctctggt gcagaaagtg aaccgaaagc ttgcagaagg 1338061 acatgacgtt atcaatctgg gacagggaaa tccagatcag ccgactcctg agcatattgt 1338121 tgaggagatg aaacgagctg tcgctgatcc tgagaatcat aaatattcgt cttttcgcgg 1338181 ctcataccgt ctgaagtcag cggctgctgc attttacaaa agagaatacg gcattgatct 1338241 ggatccggaa accgaagtcg ctgtattatt cggcggaaaa gccggtctag tcgagctccc 1338301 gcaatgcttg ttgaatcccg gtgatacgat tttagttccc gatccgggtt atcctgatta 1338361 ctggtcgggt gtcacacttg caaaagcaaa gatggaaatg atgccgctcg taaaggacag 1338421 agcgtttctc cctgattaca gcagcataac cgctgaaata agggaacagg cgaaattgat 1338481 gtatttgaat tatccgaata atccgactgg agctgttgct acttccgagt tctttgaaga 1338541 taccgtgcgt tttgcggctg aaaacggaat ctgcgtcgtt cacgattttg cttacggcgc 1338601 tgtaggattt gacggctgca agcctttaag ctttttgcag actgaaggtg cgaaggatat 1338661 cggaattgaa atttacacgc tgtcaaaaac gtataatatg gcaggatggc gggttggctt 1338721 tgccgtcgga aacgcttcgg tcattgaagc gatcaatctt tatcaagacc atatgtttgt 1338781 cagtcttttc agagcgactc aggaggctgc agcagaggca ctgttagccg atcagacgtg 1338841 tgtggcagag caaaatgcca ggtatgagag caggagaaac gcttggatca cggcatgccg 1338901 ggaaatcggc tgggatgtaa cagctcccgc aggttctttt tttgcatggc tgcctgtgcc 1338961 tgaaggctat acttctgagc agttctcaga tcttttgctg gaaaaagcga atgtggcagt 1339021 tgcggctgga aacggcttcg gtgaatatgg cgagggctac gtcagagtcg gacttttaac 1339081 aagtgaagaa agacttaagg aagccgctta tcgaattggc aaactgaacc tgtttaccca 1339141 aaaaagcatt gacaagacct tataacgatg ggataattca aaataattta taaaatctat 1339201 attttcttat caagagcagg cagagggacg agcccgatga agcccggcaa ccgacttata 1339261 aagcacggtg ctaattcttg cagctagcgg ctgagagata agattcggac gagaaacgaa 1339321 acctctttag acgcgattgc agtttgaaga ggttttttga tatggatgaa aatgaaagga 1339381 gctctggcat gagtgagtta ttagcgacat atctcctgac cgaaccggga gccgatacag 1339441 agaagaaagc agaacaaatc gcaacaggat tgacagtagg ctcctggact gatctgcccc 1339501 ttgtaaaaca ggagcaaatg caaaagcaca aggggcgggt gataaaagtt gaggagagag 1339561 agggaactgc tgcatcagaa aaacaagcgg tcatcacaat tgcctatcct gaaatcaatt 1339621 tctctcagga tattccggct ttgctgacaa cagtgtttgg caagctgtcc ctggacggaa 1339681 aaatcaaatt aatcgatctt cacttctctg aagcatttaa gcgtgcactg ccgggaccga 1339741 agtttggcgt atacggcatc cggaagctgc tgggagagtt tgagagaccg ctgttaatga 1339801 gcatatttaa aggcgtaatc ggaagggacc tgagtgatat taaagaacag ctccggcagc 1339861 aggcgcttgg cggagttgac ttgattaaag acgatgaaat tttctttgag actggtctag 1339921 cgccttttga aacaagaatt gcagaaggaa agcaaatatt gaaagaaacg tatgaacaaa 1339981 ccggacataa aacgctgtat gcggtgaatt tgaccggacg tacggctgat ctgaaagaca 1340041 aagcgagacg cgccgccgaa ttgggagcgg atgcgctttt gtttaatgtc ttcgcttacg 1340101 gcttggacgt tatgcaaggc cttgcagaag atcctgaaat cccagttccg attatggcgc 1340161 atccagcagt gagcggagcg tttacgtctt ctccgtttta cggtttttct cacgctcttt 1340221 tactcggaaa attaaaccga tattgcggtg ctgacttcag cctctttccg tctccatatg 1340281 gttcggttgc gcttccaaga gcagatgcac tggcgattca tgaagaatgt gtgagagagg 1340341 atgcttttaa ccaaacattt gctgttccgt cagcaggcat tcatcccggc atggttccgc 1340401 tattaatgcg tgatttcggc atagaccaca ttattaacgc cggaggaggc gtacatggac 1340461 atccgaacgg tgcccaaggc ggggggcgag cgttcagagc tattattgat gcggtcctag 1340521 aggcccagcc gattgatgaa aaagccgaac aatgcaagga tcttaagctt gcgctagata 1340581 aatggggaaa ggctgaagcc gtatgacgac tcgaaaacct tttattattt gtgattttga 1340641 cggaacaatc acgatgaacg acaacattat aaatatcatg aaaacatttg ctcccccaga 1340701 gtggatggca ttaaaagacg gcgtactttc caaaacgctg tcaatcaagg aaggtgtcgg 1340761 gcggatgttc ggccttctgc ccagcagttt aaaagaagag attacaagtt ttgtattgga 1340821 agatgcaaaa atcagggaag gctttcggga atttgtagca tttatcaatg agcacgagat 1340881 tccgttttat gtcataagcg gtggaatgga cttttttgta tatcctttgc ttgaaggcat 1340941 tgtggagaaa gaccgcattt attgcaacca tgcttcattt gacaatgact atatccatat 1341001 tgactggcct cattcctgca agggcacatg cagcaatcaa tgcgggtgct gtaagccgtc 1341061 ggtcatccat gaactttctg aaccgaacca atatatcatc atgatcggtg attcggttac 1341121 agatgtggag gcagcaaagc tgtctgacct atgctttgca agggattatt tattaaacga 1341181 atgccgggag caaaacctca atcatcttcc gtatcaagat ttttatgaga tcagaaagga 1341241 aattgagaat gtaaaggagg tacaggaatg gctgcaaaac aagaacgctg gcgagagctc 1341301 gctgaagtaa aacgggaatt ggcagagaga gattggtttc cggcgactag cggcaatctg 1341361 tcaattaagg ttacagatga gcctttaaca tttctcgtca ctgcaagcgg aaaagataaa 1341421 cgcaaagaga cggttgaaga ttttctgctg gtcgatcaaa acggagagcc tgctgaaagc 1341481 gggcattctc tgaaaccgtc agcagaaacg cttttgcata cacatttgta caataaaacc 1341541 aatgccggat gctgcctgca tgtccatacg gtaaacaata atgtgatttc agagttatac 1341601 ggagaccaaa agaaaatcac attcaaaggc caggaaatta taaaagcact cggcttgtgg 1341661 gaagagaacg cagaagtgac cgttccgatt atagaaaatc cggcacatat cccgacgcta 1341721 gcggcactgt ttgcggaaga gatttcagaa gattcaggag ctgttctgat ccgaaatcat 1341781 ggtattacgg cttgggggaa aacagcattt gaggcaaaaa gagtgcttga agcgtatgaa 1341841 tttttgttca gctaccattt gaaattgaaa acactcgagc atcagctggt taaataaaag 1341901 gaggaattga aatggctaca attcgaattc atgatgaggc aaatacaacg attgaaaatc 1341961 aagaggaagt ggcaagcttt ctggacagtc aagaggttat ttatgagcaa tgggatatca 1342021 cgaggcttcc ggaacatctc tcagagaaat atgacctgac agaagaagaa aaacagcaaa 1342081 ttcttgatac cttcgaaact gaaattaaag atatctcaac ccgccgcggc tataaagcac 1342141 aggatgttat ttcattgtca gacagcaatc cgaaacttga tgaactgctt gaaaacttta 1342201 aaagagagca tcaccataca gacgatgagg ttcgttttat tgtaagcgga cacggtattt 1342261 ttgtcattca aggccaggac ggcacgtttt ttgatgtccg tttaaaccct ggagatttaa 1342321 tctccgtgcc tgagaatatc cgccattact tcacgcttca ggaggaccgc aaagttgtcg 1342381 cggtgagaat ttttgtcaca actgaaggct gggttcctat ttatgaaaaa gacagcgtga 1342441 atcaataagc gtgagatagc cccgttcatc gaacggggct ttttatattt attgcaaacg 1342501 ccacttttca tattgtgaca gttctttttt aatcagtgtc caaatcaaac ctaaaacagc 1342561 tgcatcgtca atgaatccaa gaccgaggat tacgtctgga atgatatcga gcggcatgac 1342621 gatatacagg attgcggcag ttaacagcaa aagtgtttta acctgtgaac gagggtagtc 1342681 gccatttcgc caatcgcgaa gcatctgaaa aaaagtagtg atgtgctgga tacatttttt 1342741 tcggtttttc ctctttaaaa tcgcttttcc gcctgccgct ccgagcatta ttgctttctt 1342801 tttcttcatt gggcatacct cctgcctggc ggcgtgttta agatattctt cacctgggta 1342861 ttgttcttct aatcctatca atatatctat tatacctgaa aaattaactt atttaatgaa 1342921 aatatgttta caaataaagt ataatctgta ataatgcaca ataacccaat caaacttgtt 1342981 tcctatttct tagcggcgag gggtgaagtg aatgggcggt tcttctgaac aagaaagatt 1343041 gttggtgtct attgatgaaa aaagaaagtt aatgatagat gccgctagaa agcagggatt 1343101 tacagggcat gacacgatca ggcacagtca ggagctggat tgtttaataa atgaatatca 1343161 tcagcttatg caagaaaacg aacattccca agggattcaa ggccttgtaa agaaattagg 1343221 cttgtggccc cgcagagatg ttatgccagc atatgatgca aataaatagc ggcctatcag 1343281 atgcatatat aaagagagag cttttcggaa gcgctctttt tttctggaaa aaattcatat 1343341 gaaagaggga actaatgaag gaactggcga ttctcattac cgaaatggtc aatcaatttc 1343401 atgatgcttt tatttcctta tgcggaatat ttggcattca tttaactgac aaagaaatgc 1343461 atttttgggt gatcggcatt tttggcatat tctttttcgg cgtcactcac gctgtgttta 1343521 catggctttc taaatggagt atgacagcct tgtcctttat ctataccgtt acagtcatca 1343581 ttgtcatcgt atttgcgatt gagattcagc aaaaggtgac ggggagaggg aatatggagt 1343641 ttttagatgc cacggaaggt ataaagggtt ttttagtatt ttttatgttt tttttgcttt 1343701 tgaaaatgct gttgcgtttc atcaaaatcc ttttttctgg aagaccagca agcaaatcga 1343761 atggcaatgc ccgatcacga agataaaaaa ccctcctgac atggtcaggg gggctatgat 1343821 gcggatacgg ggagggtgat cgtcacctct gtgcctcttc gcacttcact ttcaatatga 1343881 atagagcctc cgtacatcag cacgatccgt ttacaaacaa caaggccgag accggttcct 1343941 ttttctttag aagtaacaaa gggaaggaag atgtgatcca gcatttcctg agaaatccct 1344001 tcaccgttat ccacaacttt gattatggct tttttatcta aagctcctag ggagatcgtc 1344061 agtttgcctc cttcaggcat tgactcgagg ccattttttg ctacatttaa aatcacttgt 1344121 ttaatatgat cttttgtaca ttttacgagt aagggctgct cggttagata ctgtaattcg 1344181 acttcaacat tgtatagatt gccctcagaa taaatgatcg gcataatttc tccgataatg 1344241 tcctgaagtg agttcagctc ccatttttca gctgtcggct tgccgagaac gagaaactca 1344301 ctcactattt gattgatgcg ctttatctcc tgttcgataa tggagaagta aagctgatct 1344361 tcctcacctt tatatttctt ttgcaacagc tgaataaagc cgcttatccc ggtgaggggg 1344421 ttacggattt catgggctgt gctggcagca agcgtcccga tcagctctaa tttttgcgcc 1344481 tcgttttctg agcgctccag ctgggtctgc cgcttcagca aataatacag cacgagaata 1344541 aaaaggatat tcagcagaac aataatacat gaaagcggaa gcacaaggct tttcgacagt 1344601 tcttctattg tgaccgggtt cggatagact ttcatattcc agctgatatc atccagatat 1344661 ccgctgacag gtttctgatc ctctgcatga gaggcttgtc cgctcgcaaa aatcattttc 1344721 ccgtcttggt tcacaacttc aatataaaca tcagggctta gtaagttaat gagatttttc 1344781 aaataatcaa tttgaatagc tgcgacaaga taatctgtca cattacgttt tgagtccaaa 1344841 acaggcacac aaattgtgaa aattggctga ccagtaattc tgctcgaata actatctgaa 1344901 atgactgtct ttttagtttc ctttgctttt ataaaaaaag atctgtcggc caggtttact 1344961 ttcgttttta attcggttgt gcttgcggtg acgtctcctt tggcattgag aaaatagaga 1345021 ccggaaaatc tcggctctga atcaaaggtc ttttccaaaa ttgattgcat tttctttata 1345081 tcaaccggtc tgtcgatggc gatggacaag gaggtcattc tcgccattgt ttctccgatt 1345141 aaataattga ttttgttgcg gtgaaggttt agcaggacac ttgcttcttg tttatgttct 1345201 gcagctattg tatctttttc tttttcatat acgaaaaagc tgatgacgat tgccggaatc 1345261 acgaccagta tgatataaag tttgactctc ccgcaggcgc cttttagtat tttcaatttg 1345321 catcgctcca acatacacct gattagaggt attatatcat tgtttcttct tctttaataa 1345381 gaaaaaataa ccaaaaaaat tagaaaaaga tgttggcaag cttacatttt aaaaaagaag 1345441 agaaatattg gaaagatttt tattgacatt ttggtctttg tttattaatg tttctctgta 1345501 acggtttcta aaaggatgat tgagacatga cagaaaaatc actgaagtta tttatcgtgc 1345561 tgtcgcgcgc gtatcggtct attaacgatc atatgaataa gcatattcat aagcatgggc 1345621 tgaatccgac tgaatttgct gtgctagagc ttttgtacca taaaggcgat cagccgctgc 1345681 agcagatagg agataaaatt ctcttggcta gcgggagcat cacatacgtt gtagataagc 1345741 tggagcaaaa agaacttctc attcggaaag cgtctcctac agacagacga gtgacatttg 1345801 cgcaaattac tgaaaaaggc atcggtcttt tgaacgatat tttccctgat cacgctgctg 1345861 aaattgatga aatgatcagc gtattaagcg aagaagaggt agagatgtgc accgaaatgt 1345921 taaaaagagt aggattaaac gcaaaacagt ttcataataa gtaaaaaaag gaagcctgat 1345981 atgtcacaag gcttcctttt ttgctatttt tcatttgttt ccgctgcgcc tctcggcaaa 1346041 atgagaactt caacccgccg gtttttgctt cggccttccg cagttttatt ggaagccacc 1346101 ggtttatact cgccataacc cttggcgctg aacacttttg catcgagctt ggggttttca 1346161 atcaggagcc ccataaagtt taccgctctc atgacgctta aatgccagtt tgattggaat 1346221 tcagaatttt taattggcat attatcagta tgtccgctga taatgatatt tcttggcggg 1346281 ttaatcacaa gaagatttga aatctctttt gcaagcggca catcttcctt acggatggtc 1346341 gcttttccag aatcgaagaa gatgctgtct ttaatcgtaa tcagaaggcc ttcactagtc 1346401 atcttcgtct ccagctgatg ttccagcttt ttatctttga tgaacttttc cacctggctc 1346461 ttcacatttt caagttcttc ttgatcagct gctttttctt tttctttctt gtttttctct 1346521 ttctcttctt tttccttttt cacttcatcg atgccgtctg actcgttttc aggaggagtg 1346581 acactggagt agtccagtac accggttccg cctgtaaaaa cttcattaaa tgattttgag 1346641 agcatttgaa acttagctgc gtcaatcgag ctgctcgcgt acagcacaat aaacaatgcc 1346701 aggagaagag taaggatgtc ggcgtaagga acgagccatg attcatcaac gtgctcgtcc 1346761 tcatgcttct tcttcttttt tctcgccatt ttgcgcctct ccttgttctg caaatttcaa 1346821 gcggtccttc gcaggaagat acattaaaag cttttgttcg atgactttcg gtgcttgtcc 1346881 ttctaaaacg gataaaacac cttcaatcat gacctcacgc agttttactt cctgttttga 1346941 ttttcgtttt aatttatttg cgaaaggatg ccataacaca taccctgtaa agataccgag 1347001 aagtgtggca acaaaggcag cactgatggc gtgtccaagc tcatctgtgt tatccatatg 1347061 agagagagcg gcaatcagcc cgattacagc gccgagtact ccaagtgtcg gagcgtacgt 1347121 tcctgcttgt gtaaaaatag cggctcctgc ttggtgcctg tcctccattg cttcgacttc 1347181 ctctgtcata atatctctta taaattccgc gctttgcccg tcaacagcca tgctgagccc 1347241 gtttttcaag aaagcatcat ctacatcctc aatgcttgct tctaaagcaa gcagaccttc 1347301 gcggcgtgca agctgagccc attcagagaa cataggaatg agttcctcta ttgtgagctg 1347361 tttattttcc ttaaataaca ctcgaaacag cgtaggcact tttttaattt cttttgttgg 1347421 gaacgcaata acgactgctg agattgtccc ggcgataata attaaaatgg cagcggggtt 1347481 tgcaagggcg ctgaaactga cgcctttcag aaccatcccg acgctcaatg ccacaaaagc 1347541 aagaataata ccgattaacg aagttttatc catagttttc accaaatcct tttttactag 1347601 cttgtctatg gttaatatcg gttttggtgc ccggaacttt agggacattg tgaatttgtt 1347661 catgaaatat tcaaggaaga ggcatagaag ggagaaataa acaaaaacgg gctctccaaa 1347721 attgaaaagc ccgggggtct actgaaatta gcagcttgct tgcaagctgt ccttcagatg 1347781 gtattcatat aatagtagaa atacatattc actgtatata aacatgttcc atccctcctt 1347841 aaaaaagtgt aaaggatgaa gggaagtagc gcttcaggag aagggacggt aatttctaag 1347901 tcaagagtat gaaagtataa aaaaaagcgg cttcctaaaa ggaaaccgct gattgttatt 1347961 ttgctcgcac tttgatttta tcatcttcta aaatcacgtg aaaacttgtg atctcgccat 1348021 tatcaagcag cagatcggtc atttcatcct caacccattc ttggatggtt cttctaagcg 1348081 gacgtgcacc gaatgaaggg tggtagccca gctcagcgat tttttctttc gcttcatctg 1348141 tcacattcaa gctaatgccc cgttccgcca atgtttcttc aagttctcca agaagaaggc 1348201 tgacgatttt gacaagatgt tctttttcca atgagcggaa ctcaataatg ctgtcaaaac 1348261 ggttgaggaa ctcaggttta aagaacatgc tcagtgaatc aattaatgtt tgttcttcga 1348321 tgacactgtc atctgattgg aaaccgactt tcgtttgttt ctcaccagca cccgcattac 1348381 ttgtcatgat gatcacagtg tctttgaagc ttacagttct gccttggctg tctgtcagac 1348441 ggccatcttc cataatttgc aggaacatat gctgaacgtc tgggtgtgct ttttcaatct 1348501 catccagcaa cacaatgctg taaggattgc ggcgcacctt ctcagttaat tgtccagctt 1348561 cctcatggcc gacatatcca ggcggtgaac cgataatttt agatacggcg tgtttctcca 1348621 tgtattcgct catatcgagt cggataatag cgtcttttgt gccgaataat tcatctgcca 1348681 gtgttttaga aagctctgtt ttccctacgc cggtaggacc gacgaagagg aaggagccga 1348741 ctggtctgtt tttggatttt aatccggcgc ggcttcgtct taccgctttt gccacttttt 1348801 gaacagcggc ttcttgtccg atcacgcgtt catgaagttt tgcttcgagt tctttcattt 1348861 tcgtttgttc gtctgcctgc agtttgccga cagggatgcc tgttttttgt tcaacaattt 1348921 cctgaatgtg ctcagcttcc acagtgacag cggtatgagc ggaggagctg ttcagttttt 1348981 tctccaatgc gagttcttca tcacggagtt ttgccgccag ttcgtaattt tcttcttcca 1349041 gggcttttgt tttttcggct tcaattgcag ttaagcgttc agcggcatcc tcatcattca 1349101 gttcatcaat taacaggttg gcttttgaac ctgcttcatc taataaatca attgctttat 1349161 ccggcaggtg tctgtcctga atgtagcggg atgataaagt gacacatgct ttgattgctt 1349221 catcactgaa tgttacgcca tggtacgcct cgtatttgtc tttaatccct tgcagaatga 1349281 ggatagcctg ttcaattgaa ggctcctgca ccatgacagg ctgaaaacgt ctttccagcg 1349341 cggcatcttt ttcgatttga cgatattctt tcagtgttgt cgcgccaatg acttgcagtt 1349401 cgcctctggc tagggccggt ttgagaatgt tgccggcgtc cattgatcct tctgcagagc 1349461 ctgcgccgac gagaaggtga atttcatcaa tgaacagaat gacatttttt cgttccttca 1349521 gctcagtgat cagctgtttc attctctcct caaattggcc tctgatccct gtgtttgcaa 1349581 caagagatgc aacatcaagc aagtatagct ctttgttttt tagtttgttt ggaacatcac 1349641 cttcagcaat ttttaaagcg agcccttcag cgatggcagt tttccctaca cccggctcac 1349701 caataagaac cggattgttt ttgtttcggc ggtttagaat ttcgatcact cgcgccactt 1349761 catcatcacg gccgatgacg ggatcaatga gaccggcttt tgcaccgttt gtaatatttt 1349821 gagccagctc atcaagcaac cctttttttt cgctttgttt tgctgcgctc tgttctttcg 1349881 gctggaatgc ctgttcaaac ggaaatccga aagattgagg acccatactc attgaaggtt 1349941 tacgggtcag ttcgttatag caagtttcac aaagaaccat ctgtttatga acggaattta 1350001 tttgcatgtt aaggcgaatc gtcgcctcgt tttgatgaca atgttgacaa cgcatttgcc 1350061 aaaacctcct taataatttg atcatctttg accaatgaaa gtgaataaaa aggtctattg 1350121 ggtttgacct tctttgacta ttagtatacg gcaaacttaa cggcattcaa accaatatgc 1350181 tcaaagcaga ctgaatattt gactatcttt gaccaattga tttttaaaaa aggccggttt 1350241 gtttgaccaa ctttgattaa tagtatactc tgactatctt tgactttcaa gtcttatgca 1350301 caaaaatttt tgatttgtta caaagtaaaa catgttttct tcgtcttttc aaggaacttg 1350361 tctcataggt tataaaaagg catatatgga caaaactgcg gttcgttcgg agggaagaaa 1350421 tggaacaatc aaaagggtct gcaagtcagc ttgcttttgt gtatgtcggc acagtagtcg 1350481 gagctggatt tgcgactggg agggaaattg ttgagttttt tctgaagttc ggctggttcg 1350541 gttttttcgg cattctcgtc agcggcggaa tgtttacgtt actgggggcc aagctgatga 1350601 tcatttcaaa gcgaatcaat gccaagtcat atcaagaaat gaacatattt ttgttcgggg 1350661 cgacggctgg gcggattatc aatgtattta tgctgtttgt tctccttgga gttacatctg 1350721 ttatgctttc aggggcaggg gcgctttttg aggaacagct ggggatgtcc gctcagattg 1350781 ggatgctcat tacaatcggt ctgagtttaa ttgtgatgac tagaggagta aaaggcattt 1350841 tcggtgtcaa tgtgtttgtt gttcctcttt taatcatctt ttcaatgatt gtggtggccg 1350901 actcttttat attcagcgaa tcacgaaacg cagctcagtg ggtctggccg catcgctggg 1350961 attggctgtt atcagcagtt tcttacgggg ctttaaattt atcgcttgcc caagctgttt 1351021 tggttccgct ggcgaatgaa atgtcatcgg agaaagtgat aaaaaaaggc gctttaatcg 1351081 gaggcacgat gctgacgatt gtgctgtccg cgagttttct gtctttgtcg actcttccgg 1351141 atgtattttt gtatgatata ccgatggcgc aagtggttta tctctttgca cgatctgtcc 1351201 atttgattta tttactcatt attttcggag aagtgttcac atcagttatc ggtaatctat 1351261 atggattaga aaaacaagtg caaagctttc ttccagtgaa aagcaaatat atctttgcag 1351321 ccattatgat cacggcttat attacgagcc aaatagggta cggcaggctt atttcaacga 1351381 tttatccctt gtttggctat gtgagcctgg ccttcatagg cgctttgctt tgcaaaaaag 1351441 ctcctcggcg gcgcagttta taaatatata taatgaaacg aaccgtcact atagagcgat 1351501 aattgatcta ggaaccgggg actgactttt ttattgtcaa gaaaaacatc attatggtaa 1351561 gatagcagaa gtgaaaaaat tgaagaaaat ccgtgcgata tgcgggagag gttctagcta 1351621 caccctctat aaaaaactaa ggacgagctg tatccttgga tacggccttt tttatgtttt 1351681 tctagagcac cttccgaaaa aaggtgtttt tttgcgtgaa ttagctgtag cgatgtctct 1351741 cgccggcgtt tttattgcgg agaaggagag gaatcatgaa aaaagaaaaa gcaattgtcg 1351801 tatttagcgg cggtcaagac agcacaacat gcttactgtg ggccttaaaa gaattcgaag 1351861 aagtcgaaac ggtgactttt cattataatc agcgacattc gcaggaagtt gaagtggcaa 1351921 aatccattgc ggaaaagctt ggtgtgaaaa atcatttgct tgatatgtca cttttaaatc 1351981 agcttgcacc gaatgccctg actagaaatg atattgagat agaagtaaaa gacggcgaac 1352041 tgccatccac attcgttcca ggccgcaatt tggtattctt atcctttgcg tctatcctgg 1352101 cttaccaaat tggcgcgcgc cacattatta caggagtttg cgagacagac ttcagtggtt 1352161 atcctgactg ccgtgacgaa ttcgtgaaat cttgcaatgt cacggtaaat ctggcaatgg 1352221 agaagccgtt tgtgatccac acgcctctca tgtggctcaa taaggcggaa acgtggaagc 1352281 ttgcagatga gcttggcgcg ctggattttg tgaaaaacaa cacgctgaca tgctataacg 1352341 gcatcatcgc agacggctgc ggcgaatgtc cggcatgtca ccttcgttca aaaggttatg 1352401 aagaatatat ggtgatgaaa ggagagcgtg cataaattgt tatctcaaat ttatccgcag 1352461 gcccagcatc cttattcgtt tgaactgaat aaggacatgc atatctcagc cgctcatttt 1352521 atccctcggg aaagtgcggg agcgtgcagc agggttcacg ggcatacgta taccgtaaat 1352581 ataaccgttg ccggcgacga acttgacgat tcaggctttc ttgtcaattt cagcgtactc 1352641 aaaaaactgg tgcacggaaa ctatgatcac acgctattaa atgatcatga agatttttct 1352701 caggacgacc ggtattcgct gccgacaact gaagtcgtgg cgaaaacgat ttatgacaac 1352761 gtacaggctt atttagacac tttggagaat aagccgacct gtgtacaggt gtttgtccgt 1352821 gaaacaccga caagctactg tgtctaccgt ccgaaaaagg gtggtttgaa tggctaaagg 1352881 aattcctgta ttagaaattt tcggcccgac gattcaagga gaaggcatgg tgatcggaca 1352941 gaaaacgatg ttcgtccgga cagccggctg cgattattcc tgcagctggt gtgactccgc 1353001 tttcacttgg gacgggtctg ctaaaaaaga tattcgctgg atgacggcgg aggagatttt 1353061 tgcggagctt aaggacattg ggggagatgc gttttctcat gtgacgatct caggcggcaa 1353121 cccggctctg ttaaaacagc tggatgcttt tattgaactg ctgaaggaaa ataacatccg 1353181 tgcagcgctt gaaactcaag ggaccgttta tcaggattgg tttacgctga ttgatgacct 1353241 gacaatttct ccaaaaccgc caagctcaaa aatggtaacg aactttcaaa agcttgacca 1353301 cattttaact tcacttcaag agaatgatag acagcatgct gtcagcttga aggttgtcat 1353361 ctttaatgat gaagatctgg aatttgccaa aactgtgcac aagcggtatc cgggaatccc 1353421 gttttattta caagtcggaa atgatgacgt gcatacgaca gatgatcagt cactgattgc 1353481 acatttgctt ggaaaatatg aagcgcttgt tgataaggta gctgtcgatg cggagctgaa 1353541 tctcgtcaga gtgctcccgc agctgcacac cctgttatgg ggcaacaaac gcggagtata 1353601 atagaaagga agatgaacat gacgacaaga aaagaatcag aattagaagg tgtaacattg 1353661 ctaggcaatc aaggtacaaa ttatttgttc gaatatgcac cggacgtgct ggaatccttc 1353721 cctaataaac atgtaaaccg tgattacttt gtaaaattca attgcccgga attcacatct 1353781 ttatgtccta aaacaggcca gcctgacttt gcgacaatct acatcagcta cattcctgat 1353841 gaaaaaatgg ttgaaagcaa atcattaaag ctgtatctat tcagcttcag aaaccatggt 1353901 gacttccacg aggactgcat gaatatcatc atgaacgact tgattgaatt aatggacccg 1353961 cgctacattg aagtatgggg caaattcacg ccaagaggcg gaatttccat tgatccgtac 1354021 acaaactacg gaaagcctgg cacgaagtat gagaaaatgg ccgaataccg tatgatgaac 1354081 catgatttgt atccggagac aattgataat cgttaattat tccgttgtgt gatacggagt 1354141 gtaaaaggaa gtggagtcac agtaaaatcc gaacattcag cgttaatttt cagcggaaat 1354201 gtgacctggt cacagcgaag tgtgacccgc actaagctca ataaaagtgg gaaaagtcac 1354261 acctgaaaat ggctctactc atgggaattg tattaaaaag tgtgacctga ggtgcaacct 1354321 gaactgtgac ttttatgcag tgaaaaattg atagtacaga agcagattaa ggcgtacaat 1354381 ttgtacgtct tttctttttt atccgaaaga aaaaatgcct atctagagat cataggcatt 1354441 aaatattatt atcaatatct tcatttattt tttggctaag tttctgaacc ttctctttaa 1354501 catttgaaac agctcttttt tgaatttcat caattctcct gaatatagtc gatgacactt 1354561 cttattagaa cttcactttc aaaattgaat atctcattta tttctgactg ttcttcatct 1354621 gttaggtgat ggtattgaag ttgtttagca tttacttcag cagctacatc aatcctaact 1354681 tagttgttct ggttgtacaa tttcatattc accttctgca tactcttgct ccgcataata 1354741 gcctccccat tgacagagct cctgcaagat aggtttaaga gattctccaa gttcagtgga 1354801 tgaatattca accttcggcg gtacttgatt atacatcttt ctgctcacaa gtccactggc 1354861 ttcaagctct ctaagtgttt gaatcagcat tttctgagtt atatttggga taatgcgctt 1354921 taattcactc gttctctttg gtccattcat taaaaagtat aatacaaggc ctttccattt 1354981 tccgccaata acttcctttg tcacttcaaa cccacagcta aattttttca tgtctaaagc 1355041 tctccattcc acatttatta ctttttagtt actatatcac aaaaaagtgg gtacttccga 1355101 taatgtgctt actgaaggat actatatctt gtaagttgtt cttcaagtac ttaaaggtac 1355161 tagacataaa ataaaattaa ttctaaagga gtgttaagta tgggtaaatt tgaaggtaaa 1355221 atagcgcttg taacgggtgg aacaagtggg attggtcttg ctacagcaca aaaatttgta 1355281 aacgaaggtg catatgttta tattacggga cgtagacaaa acgaacttga taaagctgtt 1355341 aaccaaattg gcaagaacgt aaccggtgtt caaggtgata tttctaagct tgaagactta 1355401 gacaaactat atgacattat aaagcaggaa aaaggtaagt tggacattct ttttgctaat 1355461 gcaggcatcg gcaacttcct tccattaggt gaaattactg aagagcaggt tgatagaacg 1355521 ttcgacatta acgttaaagg aaccatcttt actgttcaaa aagcgttatc actattcccg 1355581 gacaaagtag gttctattat tgtaacgggc tctactgctg gatcaattgg caacccagcg 1355641 tttagtgtat atggagcatc taaagcagca ttaagagcac tagttcgcaa ctggattctt 1355701 gacctaaaag gtactgaaat ccgtgtaaat gtggttagtc caggaggtat tcttacacct 1355761 gcctacgatg agctttttgg tgatgcactt gaagaggtac tggaaaatag cagaaatact 1355821 gttccagctg gaaaagttgg gacacctgaa gaagtagcaa acgctgtatc tttccttgct 1355881 tcagacgaaa gcagttactt gacgggtgtt gaattgttcg tagatggcgg gctagcacag 1355941 gtataatttc actgcgcaga gattacaaat agtccccaaa aaaggttaat ggggatttac 1356001 ttgaagaagt cgtataaaaa agtcgttttc cttaaaggac agggaattcg acttttttat 1356061 atttgaattt gattaacgtt gtaaattcgc attttcctgg ggctactact aaatgacctg 1356121 taaaaaagat tacactgtga ataaatgtac ttaaagtaac gggggctctt gacttttaat 1356181 aaaaaataat atccctgtcc ttgtattcta atacttttaa aaatatttaa aggaatcctt 1356241 atgtcctgaa taaccacata ggaaaatatg ttgtaggttg ctttcttttt ttgtggggca 1356301 tcccacacaa gctatctcgt gatctcacac ctgaacgttt tttatagact agtaccgcga 1356361 caagttatat tacatataca taccaataaa gtagacatta aaaagtgaaa gagaggatgg 1356421 aaatgtgtga aaattctttt ccttgagagt catcccatgt ggctctatgg tttaccgaat 1356481 gggtttaggg aagcaggaca taccgtaatg atttccggtc ctgtaagtcg ggaaaatata 1356541 actgaaatga tagacgaatt taaaccagat ttaatagtat ctatgggatg gacaccagag 1356601 cattcaaggg aaaagcaggc ctggattcgc aacgctacta aaaaggtgaa tatccctctc 1356661 gtttattggg caactgaaga cccgctgcac actcaaaact ttactatccc gttaattaaa 1356721 aagatgaaac cggattttgt tttcacggtc acgccttctc tgtgtaaaac ttatgaaagc 1356781 atggggatta aagcagctca cttagacttt gcatttcacg aaagtataca tcaccagatt 1356841 aaaccattag cgaaatacag ttgtgatata gcagtggtgg ctaatgctta ccctaatttt 1356901 cttgaagaac atccggaagt gttccgttcg tcctctttaa aaacgcttat tcgtcctctt 1356961 atacggaagg gtattcgcat tgatttttgg gggagaaact gggaaaaaat gagtaaatat 1357021 ataggaagag aaattccccg caattggatc catggatacc ttgattatac tgaagcatat 1357081 aaagtttaca gttcagcaaa aatcattatc ggtttgcaaa actgtgaaag ccaacttaca 1357141 caacgcacct atgagattct tggttccggg gggtttttat tgacatcgga tacaccagca 1357201 gttcgaggta aattcaaacc tggccgcgat ctcatcgttt cttcctcccc aaaagaaaca 1357261 ttggaaaagg ttaaatacta tttaaatcat gatagcgaga gaaaaaagat tcagataaac 1357321 ggtaaaaagg ctgtaaagaa tgattcctat cggcatagag ccgagagaat gcttgaggtg 1357381 ctaaaaagca gaggaatcat aagaaactta ggggaaacca ttcattatgt agatgttctc 1357441 aaagaaaaat acgtgatcca tcatgttact cccggtgaaa cattatcaat aattgccagt 1357501 aagtataatg tttccctgca gcaactcatg gagcttaatc atttcaaatc agatcaaata 1357561 tatgctggac aaatcattaa gattagagag aaactgttta gaaatattaa taacaaatta 1357621 ttctaaagga gagtaatatg aatgaagggg aaaataccta aaataagaaa tcaagcgaat 1357681 aaagtaaaaa gaacgcctcg ttatatggaa tttcccgtga catacgaagt atatcatgtg 1357741 gaatccggcg atacattatg gacgattgcc aaatcctttg aaattccggt acaacaactt 1357801 atgaatctta ataagctttc ttcagataga atttatcctg gacaaattat aaagataaga 1357861 gaaagataat ctttgaggtt tcggaagcga atcaaattga aatgacaatc ctcatttttt 1357921 tatttgtggg gaacttgata tttttgggga tgaaggggtt atgagatgtt tcaaatgagc 1357981 tattactatt ctggattagg atgggacttt attcaacacg ttgatcaaac gaacggagta 1358041 ttaaatgttg tgtctcctga ttttttctat atcagaaaag atggatcatt acttctccgt 1358101 tcagctaatc ccgatgtgat taaagctctt catagaagaa aattaaaagt agttcctttt 1358161 ctaagcaatc attgggatca ggatttggga cgatttgcat taatgaaccg agttctttta 1358221 gctaaacaaa tttctcatgc aatagaagaa ctggatttgg atggagttaa tatcgatata 1358281 gaaaacctta cagaaaaaga tcggaatcta tttacagatt ttattagatt agtaaggaaa 1358341 agtattccta gacataaaga agtatcagtt gcagtggcgg caaatccttt tggctggacg 1358401 aagggctggc acggatcata tgattacgag tatttagcta aatatgcaga ttatcttatg 1358461 gttatggcct atgatgaaag ccgccttgct gggcctactg caagtgtagg atgggtggaa 1358521 aagtccattc aatatgttct gacccaaaaa atctctcctc aaaaactagt tttaggattg 1358581 ccattctatg gccgctgctg gatggaaggc caatctgcct ctcaagccat tcccctttac 1358641 cttgttgtta gtaaaaaggc atagcgggac aattattttt gacaccaaga gtcaatctcc 1358701 aaaagctatt tttactgtca atcacgataa aaaggggccg ttgccttcgg gaacatatac 1358761 attatggttt gaaaatgaac agtcactcag agcaaaaata aaactcgctc aaaaatataa 1358821 tctgaaaggt cttggcagct ggagtcttgg acaagaagat gcgtcagtct ggaatacagt 1358881 gtttaaaaat atataatgat ttatagttca gaacaaaatt cgaagataat tgcaatgaat 1358941 ctctaaatgg acatactgaa aggagtttat tacgagtgcg ggtaaaacag tgagggcatt 1359001 ccataggccc ttctcccaaa atgttctaca cgaggcatta cattgggctt gaaatacaca 1359061 ttcaaactta tgttatagta cgcattttac ggatgtgttg aatttattct gcttccatga 1359121 tttaatcata cacatgctac ttgatagcag ggttatcgca tttcattcag aattgttcag 1359181 gatcgatatg gaagcgcacg actaactaga actttaaaag catacactca tatacttcct 1359241 gaatggatgc tggtttatct aaaaaacatg atgagaattg attgtacgca tggtgaagca 1359301 tgacttgttg ataatcgacc atatggtttc tccttagaaa tgagggggtt tttacataaa 1359361 aaagacgagc gaatccgggg ggaattccac tcgccgcttt ctaatgaaaa gacgggatgc 1359421 tggatggcag ctcgtctgtt ttattataat ttaacgaacg tatgtttgta aaggtgtctt 1359481 ttcgaatgaa ttggttcata taaccgttaa gaacagattc attgtaaaca ttcgctaagg 1359541 tatgctaaga tgcatggact ataaaggagt gatatgaagt gaagacattg cggttaaaca 1359601 atgtaacgtt agaaatggct gcatatcaag aggagagcga gccgaagcga aaaattgcat 1359661 ttaccttaaa cgttacgagt gagacttacc atgatatcgc tgtcctgttg tatgaaaaaa 1359721 cgtttaatgt cgaggttccg gaacgcgatc ttgccttccg gggggaaatg acaaattatt 1359781 caacatcatt gaccaacctg tacgaaccag gggccgtcag cgagttctat atagaaataa 1359841 cggaaataga caaaaacgcc gattcatgat cggtgttttt tatgtaaaaa agctgccggc 1359901 cggcagcttt tgagaaagcg aatttcatat gtaaggtgtt aaattgtccg tcttgcagtt 1359961 ttttgaataa atgtggaaat aaggaggttt taataggagt ctctgatgat cttataattt 1360021 ttatgattaa caactgtcaa tgaatctaac tcaagatccc gatagttatc catgatcgtc 1360081 acatcaacga taacagaatt ctcatttact ttttcaacaa caccggttaa tccgttttta 1360141 aattcaatga cattcccaac cttagcgatt ttcacaagct tcctctcctt taaacataat 1360201 aatgcctttt gaaagtattt tgcagtattt tcattgagaa gtaaagcgat aaggagtttt 1360261 atctccctta tgaattgttc tgtcgctata aagatgatat attgattttc gtcaatagaa 1360321 agaaaagggg ggaatttttg ttgcgtcccg aagaaataac agaaatgatt gaacagctgc 1360381 gcaccggcgc cataaacgaa ctgagagtcc agaaagagca ttttcttgat ttcagggccg 1360441 tgttatctaa acaagatgat tttaaacatt tccgaggaat tgcccagcaa ggcggagatg 1360501 ttatctttca atacttagaa cagccaagaa gctgaaggtt tctcatacgt gagaagcctt 1360561 tttatcatat atgacagaac acaagccttt tattacagct gtctgtaaca ggtgtaaata 1360621 aaatgtaaag taccaaagat ggataaacat gttttaattt aacaatattt atagaatttc 1360681 agactgtttt tttgccatta agcagtgagt catcctcttt attccatcct gatacctcct 1360741 tgggagagtt ggaaaatctt tttccgtgaa aatgaatgga tctcttgtta aggttatgaa 1360801 gtgttttttg gagcacttta aggaggaaac tgtatgacaa cgaaattcac tgctctggct 1360861 gtttttcttc tttgtttcat gcctgcagcc aaaattgagc atacacaagc ttcactactg 1360921 agcgcaaaga agacaaaaca tgaagaagcg aaatggctta cacatataga tcgaaatacg 1360981 aatgaatctt tcccttcact gtctgctgat aaagacaaga aaataaaacc gattaagcta 1361041 tcagcacaca ctgaaaagaa agagaaagat aaaccggaca aaacaaatga tgagaaagaa 1361101 acatatacac agtctgaaaa agagttgctg tcccgtctcg ttcacgcaga ggccaaagga 1361161 gaatcatata aaggcaaggt cgctgtagca agcgttgtac tgaacaggac ggagaaaaaa 1361221 ggttttcctg atacgataag aggagttatt tatcagaaaa acgcctttga accggtcgca 1361281 aacgggagca ttaaccaaaa gcctgataaa gaatcgattg aagctgccga agaagcgctg 1361341 tcctcaaaaa atagagaaac agatgccata ttcttttata atccgaaaac agcgtcagat 1361401 aattggattc gttcaagaaa aatcgtagaa aaaatcggca gacacgtttt tgccgtctaa 1361461 gcatagaaga gacaatttgt ctcagctgtg ctttttttca tataaagagt aaaaataaaa 1361521 taatttttga acttgtctca tatgatgttg gtagtacaag agacaaggag agacatcatg 1361581 aatcgatttg tgaaagggat cattctttta tccattgccg cctttttcgc tgaatgcctt 1361641 gaatttgtcg tcaatatgat tttggcgcgg gagcttggcg agcatgggat ggggctttac 1361701 atgagtattt tgcccacgat ctttttaatt attgtcatcg cgagcctgga actgccgata 1361761 tccatttcta aattcattgc cgagtcaaat cctaagcttc atgaaagcat gctgaggcac 1361821 gctttcagaa tgacagccat ttttactgct ttttctactg ccgccgctag tattgcgctt 1361881 ccgtttattc cggtatttga tacataccac ccgtttatta aagggattgt catcggctta 1361941 attcctgttg tcgcctttac ttcaatcgcc aggggctact ttatgggtgt gcagaaaatg 1362001 gggaagatcg caattgccaa tgtgctgaaa aaaatcatcc agctcttgtg cttattcctc 1362061 ttttttcaat ggtactcatt tgaattggac atggctgtgc tgatttcctt gtttgttcta 1362121 gtcgtgagtg atgtggtcgt gcttgtttat ttatattcac aatttatcat ggcaaggcgg 1362181 gcgttatccg gccagcagca cattcatttg cgcggaaagg atgtaaggaa aagactgctt 1362241 gctgtttcaa ttcctacaac aggactgcgt atttttcatg cggttgtcaa tgcaattgaa 1362301 ccctttttag taaaaggagc tcttttggct gcgggcgttg ccgggacagc ggcgatcgat 1362361 caatacggaa tgctggcagg agtggctgtg acgatagggt cgttccctgc ttttattgcc 1362421 cattcgttaa tggtcgtcat gataccgagt atttcggaag cttatgcact ttctcagtat 1362481 gacatcgtgt taaaaaggct gaagcagtcg attttcatta cattaggtta cggtatacct 1362541 gccgtctggg tcatgttcca gtttgcggga cctctcacgc atttgttttt tcactctcct 1362601 gaagcgcagt attacttgca gctgttgtgg ccttactttc tctttcatct gtttgtcatg 1362661 ccgctgcagg cgtgcttaat cgggatgggt tttgtgaaag aggcttttta tcacaatgta 1362721 tggagccata tcgttgcgct aagtatgatg tatgtactgg gatcaatgga gaatctgcaa 1362781 atgctcggga ttatccttgg aatgaacact ggcatgattc ttttgacgag cctgcactat 1362841 gccacgatct gcaaagcatt gaaggtatct gtatttctta cgggagggac cagaacgccg 1362901 cgaattgaag gatgataaag gaacagcagg ggcaagctaa ttgaaaagca tgaaaggaag 1362961 attccatgtt gacgaagcgc ttgcttacta tatacattat gttattaggg ttgattgcat 1363021 ggtttccagg tgcggcacaa gctgaggaaa aacagcctgc tgttcccgct gtttttctta 1363081 tgaaaacgat agaaggggag gacatctcga ttccgaataa agggcaaaaa acaattctcc 1363141 atttttggac gtcatggtgc ccgccctgca aaaaggagct tccacagttt caatcgtttt 1363201 atgatgccca tccatccgac agtgtaaagc tggtaacggt gaatttagtg aattcggaac 1363261 aaaatcagca agtcgttgaa gactttatta aagcaaacaa gctgacgttt ccgattgtcc 1363321 ttgactcaaa aggggaattg atgaaggagt atcatatcat cacgatccca acatcatttt 1363381 tgctgaatga aaagggagaa attgaaaaaa caaaaattgg cccgatgaca gcggaacaac 1363441 tgaaggaatg gacggaagaa tagctgagag catagactct cagctttttt catatagaga 1363501 agaagtgaat aaacattaat gataattatt atcaaaaaga aattaaaata attataattg 1363561 aaattctctt cgtgcgtgct ataataaagg aagacatcaa gaaataactg acgataaagc 1363621 tgccttttgg gcagcgattt tgtttttata agagaaatga agatgattta cgttctcaat 1363681 tagagaggag aattcgatat gaatgaacaa gttatcgttc aacgcgaccc gcatgagcca 1363741 ttgaaaacag acaagaggga aaaaaactgg gcacagcacg cggagcttat tgcagcactt 1363801 gtatcaggcg ctcttatttt ggcaggctgg ctcttatccg gatatcaggt attatccata 1363861 atacttttct tgctggcttt tgtgatcggc ggatttgcta aagcgaagga aggaatcgaa 1363921 gaaacactcg aatccaaaac gctgaatgta gaacttttaa tgattttcgc tgccattggt 1363981 tccgccttga tcggatactg ggcagagggt gctattttaa tatttatttt ttccttaagc 1364041 ggagctttag aaacatacac gatgaataaa agcagcagag atttaacgtc tttaatgcag 1364101 cttgagcctg aagaagcgac attgatggtc aatggtgaaa ccaaaagagt tccggtttca 1364161 gacttgcagg ccggtgatat gattgtgatc aaacctggag aacgcgtagc ggcagacggt 1364221 atcattgaat cgggctcgac aagtcttgac gagtcggctt taacaggtga atcaatgcct 1364281 gtagaaaaaa acacaggcga cactgtattc acaggaacgg tgaatcgcaa tggctccttg 1364341 acagtccgtg tcacgaaagc aaatgaagat tcgttattca gaaaaattat caaactggtt 1364401 gaatcagcgc aaaatagtgt ttcacccgcg caggctttca tcgaacgatt tgaaaatgct 1364461 tatgtgaaag gtgtgctaat tgcggtggcg ctccttttat tcgtcccgca ctttgcgctg 1364521 ggctggagct ggagtgaaac cttctaccgc gcaatggtgt ttatggttgt cgcgtcacct 1364581 tgtgcgcttg tcgcctctat tatgccggcg gcgctgtccc tgatttcaaa tggcgcccgc 1364641 aacggtatgc ttgtgaaagg aagcgtcttt cttgaacagc tgggctcagt gcaaatgatc 1364701 gcctttgata aaaccggaac tgtaacaaaa ggccagcctg ccgtagagac gatcagaata 1364761 gcagaaggat tcagtgaagc ggaagttctt gaggctgtct atgccatcga aacgcaatca 1364821 agccatccgc tcgcccaagc cataacggcg tacgctgaaa gccgcggcgt gaatcagtcc 1364881 ggctacatat ctatagaaga aacctcaggg tttggcgtta tggcagaagt gtcgggtgcg 1364941 aaatggaagg tcggtaaagc aggttttatc ggcgaggaaa tggcagcaca atttatgaaa 1365001 caaacagcat cagatgtcat tcaaagcggt catacaattg tatttgtgaa aaaggatgat 1365061 caaatagcag gctgtatcgc actgaaggac caaatcaggc ctgaagcaaa agaggtcatg 1365121 gaagaactga accgacttgg gattaaaacg gccatgctga caggagatca cgaagacacg 1365181 gctcaagcga ttgccaagga agccggcatg acaactgtcg tggcagaatg cctgcctgac 1365241 caaaaagtga atgaaatcaa acggttaaaa gaagaattcg gaacgattgc aatggtgggt 1365301 gacggaatca atgatgcgcc ggcactcaaa gcagcggatg tcggcattgc gatgggcggc 1365361 ggaacagatg tagcacttga gaccgctgat atggtcctca tgaaaaacga tttgaaaaag 1365421 ctcgtaaaca tgtgccgctt gtctcggaaa atgaacagga tcatcaaaca aaatatcgtg 1365481 ttttctctag ctgtaatctg cctgctgatt tgtgcaaact ttttgcaggc gatggaattg 1365541 ccatttggcg tgattggtca tgagggcagc acgattttag tcatactaaa cggtttaaga 1365601 ctcctaaaat aaaaccagca gcctaatcag gctgctggct ttttatgtat caagctttcc 1365661 cttcattttt gtctttatca gatcttttca taactaggat gagagcgagg gtgcagcaaa 1365721 ggaaacccgc tgcacagcct atgatagagc tgtaataata aaagcccacc atcttcatcc 1365781 cgataaaagg agcggaaatt cccaaaaccg ttaagagcat aactgctttt cgtctgaaaa 1365841 aattcatcag caaacggaac aacccccctg cgattgaacg ttactgtcag tatacaggaa 1365901 gaggagcagg aaataaaatg cattagaaaa tgaaggcgtc gtgaaaggca aacaccggta 1365961 aaacctgtta caatggaaga cagaacaatg cattgcaaat ggcagggagg aacaagaagt 1366021 gaatagaata caacgcgtct cttcatggct gaaggaagcg gggcatactg ccgcatttat 1366081 tcatacgaaa gaaaatgttt tttacttaac cggtttttac acagagccgc atgaaagatt 1366141 aatggggtta tttatttttc aagaagagga gcctttcttt gtttgtccag gaatggaagc 1366201 aggacaggcc cgcaacgcag gctggaatca tgaaatcatt ggctatgcgg atcacgaaaa 1366261 tccgtgggag ctgatagaga aggctttgaa aaagcgaaat atcagcatac atatgcttgc 1366321 ggtagaaaag gattcaatct cgctgtcacg tgcagaacag ctgaagcatg cgacgggcgg 1366381 ggctcaattt gtttcagcag aagaaacact caatcaattt cgcctgatta aagatgacaa 1366441 tgagattcgt ttgctgaaag aggcggcaaa gcttgcagat tacggtgttg aagtcggcac 1366501 agccgctttg cgtgaaggca tcagtgaagt ggaagtgctc gctcaaattg agtatgagct 1366561 gaagaaaaaa ggaattcagg gcatgtcttt ctctacaatg gttttattcg gagaaaaatc 1366621 tggccagcct catggaaatc ctggtacagc cacgttgaag aaaggtgatt ttgttttatt 1366681 tgatctcggt gttattcttg atggctattg ctctgatatt acaagaacgt ttgcatacaa 1366741 aaccatcaat ccgaagcagg aggccattta cgagactgtg cttcaagcgg aaaaagccgc 1366801 gattgaggca agcaaacccg gtgtgagaat cggagatctg gatttaactg cccgcggaat 1366861 cattgaaaaa gcgggatatg gtgattattt tcctcaccgg cttgggcatg gactcggaat 1366921 ttcagtccat gagtatccat caatgagcca ggccaacgat acactgctgc aggaaggcat 1366981 ggtctacacg atcgaaccgg ggatttatgt gccagagatc ggcggcgtac gcattgagga 1367041 tgacgttcac gtaacaaagg acggagcagt tgctctgacc caatatccaa aggatttgat 1367101 catactgtaa tagaaataaa aaaggacttt gttctcgaca tcgtcctttt ttatctgcat 1367161 taaataaaaa aatcatcaaa tgttcgaaag ggtttaattt catgtttttg gttgagaggt 1367221 tttacagcaa gacagctgcc accgagaaca gtgagacata acccaattaa aatgaagaaa 1367281 cccatgtgat cttctccttt cagctaaaaa cacaaaaaga tatctggtac gtccatatca 1367341 tattgtatga aacgcattcc agatcaaggg gatttagaaa gaagggaatc tatggctaat 1367401 attaaagaca ttgcagagaa agccggtgtc tctgttacaa cggtttcccg agtcataaac 1367461 aatcatccat acgtcagtga agacaaacga aaaagagtgt ttgaggcaat ggaatcattg 1367521 gagtacacga gaaatattca cgctgtacat ttgtcgaaag gattttcaaa catgattggt 1367581 gttgtcttgc cgacggttaa tctgccatat tttgcagagc tgattgcagg aatagccgac 1367641 gcagccgcgg aatccggggt tcacctctct ttattccaaa caaactatga agtacaaaaa 1367701 gaaatctttg cgctgtccca attaaagcag cgccaggttg acggcctgat tttttgctca 1367761 aaggcgcttg ctgatgagaa actcatggaa tgggagggcc cgattttgct ttgccagaat 1367821 tcagataatg cccgcttccc aaccatcagc attcctcacc aagaagcatt tcggaacggc 1367881 ttggactatt taattgccaa agggcacaaa aaaatagcca tctgtttggc aagaaaaaaa 1367941 ggcatgaaca gccattttcg aatcaaagcc tacaaagagg cattggaaga gatcggcgag 1368001 gcatttcgtg aagactgggt aattgagaaa gcgattacaa tcaatgatgg gaaggcgctt 1368061 tttcataaat ggaatacgtg gaaggaaaag ccgacggcta tttttgttgc caatgaccaa 1368121 gtctcagcag ggctttttct tgaagcaaag aaccagcggg tgtcagtacc ggatgagctt 1368181 gcaatcttaa gcgttgataa ccacgaaatc agccaagcgc ttggaatcac aacgatcgat 1368241 attcagacaa gggaaatggg aaagcaggca tttgccatat tggaaaaaag aattcaagga 1368301 cagccgattg aaaggaaagt tctggattac cgtctcatcg aaagatcgac tgtttagtga 1368361 atgcattgaa aaaaggtttg acgtgcattc tgttcgttat gtacgatatg aggtattgaa 1368421 tgacaaagga gctgaggatc gtgaatgggt ccttcacagt gaaaaaggta ctgaataata 1368481 acgtattaat tgcttctcat cataaataca gcgaagtcgt tttaatcgga aaaggtattg 1368541 gtttcggaaa aaaacaagat gatgtcattg aagataaagg ctacgataaa atgttcattt 1368601 taaaagacga gaaggaacaa aagcagttta aaaagctcct tgactatgtt gatgaaaagc 1368661 tcgttgatat ttcaaacgat gtcatctatc acataagcaa taggacgaat cactcattaa 1368721 atgaacatat tcacattgcg ttgacagacc atatcgcatt tgcgatcaaa aggcagcagc 1368781 agggatttga tatgaaaaat ccatttctaa tggagactca gtcactatat cctgaggagt 1368841 accaaattgc caaagaagtc atagatatga tcaatgaaaa agcgggactc tgccttccgg 1368901 aaggggagat tggttttatc gctctgcata tccattcagc gttgacaaac cgtccgctgt 1368961 ccgaggtcaa tcagcactct cagctcatgg cgcagcttgt cgaggtgatt gaagactcat 1369021 ttcaaatgaa agtaaataag gaaagtgtca actatttgcg gctgatcagg catatcagat 1369081 ttacaataga aagaattaaa aaagaagaac cgactaaaga accagaaaaa ttaatgttgt 1369141 tattgaaaaa tgaatatccg ctatgctaca atacagcttg gaaattgatt aaaatcttgc 1369201 agcaaacatt gaagaaacca gttcatgagg cggaagcggt ttatctgacg cttcatctgt 1369261 accgattaac caataaaatt tcataaattc agtttatcct tataacgtgt tactgattcg 1369321 atcaggcatg agtgattgag ggaaaaaaac gggaagttca ttctcgttct tttgcgcacc 1369381 caattttgct catgcctttt tgttgtgtaa aagggcaaat gtaaacggtt aaactggaag 1369441 acttacgcct gtgaattcgt tgtcatgatt tttagctgta aggtcagact agtaaaaaga 1369501 ggaggtcaat tcttatgttt aaagcattat tcggcgttct tcaaaaaatt gggcgtgcgc 1369561 ttatgcttcc agttgcgatc cttccggctg cgggtatttt gcttgcgatc gggaatgcga 1369621 tgcaaaataa ggacatgatt caggtcctgc atttcttgag caatgacaat gttcagcttg 1369681 tagcaggtgt gatggaaagt gctgggcaga ttgttttcga taaccttccg cttcttttcg 1369741 cagtaggtgt agccatcggg cttgccaatg gtgatggagt tgcagggatt gcagcaatta 1369801 tcggttatct tgtaatgaat gtatccatga gtgcggttct tcttgcaaac ggaaccattc 1369861 cttcggattc agttgaaaga gccaagttct ttacggaaaa ccatcctgca tatgtaaaca 1369921 tgcttggtat acctaccttg gcgacagggg tgttcggcgg tattatcgtc ggtgtgttag 1369981 ctgcattatt gtttaacaga ttttacacaa ttgaactgcc gcaatacctt ggtttctttg 1370041 cgggtaaacg tttcgttcca attgttacgt caatttctgc actgattctg ggtcttatta 1370101 tgttagtgat ctggcctcca atccagcatg gattgaatgc cttttcaaca ggattagtgg 1370161 aagcgaatcc aacccttgct gcatttatct tcggggtgat tgaacgttcg cttatcccat 1370221 tcggattgca ccatattttc tattcaccgt tctggtatga attcttcagc tataagagtg 1370281 cagcaggaga aatcatccgc ggggatcagc gtatctttat ggcgcagatt aaagacggcg 1370341 tacagttaac ggcaggtacg ttcatgacag gtaaatatcc atttatgatg ttcggtctgc 1370401 ctgctgcggc gcttgccatt tatcatgaag caaaaccgca aaacaaaaaa ctcgttgcag 1370461 gtattatggg ttcagcggcc ttgacatctt tcttaacggg gatcacagag ccattggaat 1370521 tttctttctt attcgttgct ccagtcctgt ttgcgattca ctgtttgttt gcgggacttt 1370581 cattcatggt catgcagctg ttgaatgtta agattggtat gacattctcc ggcggtttaa 1370641 ttgactactt cctattcggt attttaccaa accggacggc atggtggctt gtcatccctg 1370701 tcggcttagg gttagcggtc atttactact ttggattccg atttgccatc cgcaaattta 1370761 atctgaaaac acctggacgc gaggatgctg cggaagaaac agcagcacct gggaaaacag 1370821 gtgaagcagg agatcttcct tatgagattc tgcaggcaat gggtgaccag gaaaacatca 1370881 aacaccttga tgcttgtatc actcgtctgc gtgtgactgt aaacgatcag aaaaaggttg 1370941 ataaagaccg tctgaaacag cttggcgctt ccggagtgct ggaagtcggc aacaacattc 1371001 aggctatttt cggaccgcgt tctgacgggt taaaaacaca aatgcaagac attattgcgg 1371061 gacgcaagcc tagacctgag ccgaaaacat ctgctcaaga ggaagtaggc cagcaggttg 1371121 aggaagtgat tgcagaaccg ctgcaaaatg aaatcggcga ggaagttttc gtttctccga 1371181 ttaccgggga aattcaccca attacggatg ttcctgacca agtcttctca gggaaaatga 1371241 tgggtgacgg ttttgcgatt ctcccttctg aaggaattgt cgtatcaccg gttcgcggaa 1371301 aaattctcaa tgtgttcccg acaaaacatg cgatcggcct gcaatccgac ggcggaagag 1371361 aaattttaat ccactttggt attgataccg tcagcctgaa gggcgaagga tttacgtctt 1371421 tcgtatcaga aggagaccgc gttgagcctg gacaaaaact tcttgaagtt gatctggatg 1371481 cagtcaaacc gaatgtacca tctctcatga caccgattgt atttacaaac cttgctgaag 1371541 gagaaacagt cagcattaaa gcaagcggtt cagtcaacag agaacaagaa gatattgtga 1371601 agattgaaaa ataagggtgt tagtacgccg tgcttgtcag atgacaagta cggttgtatg 1371661 atataatatt gtgaagtaat aaagctttaa gttaaaagga gaatgataaa aatggcacaa 1371721 aaaacattta aagtaactgc agattctgga atccatgctc gtcctgcgac agttcttgta 1371781 caaactgcta gcaaatacga cgctgacgtt aatttagaat ataacggcaa aacagttaac 1371841 cttaaatcta ttatgggtgt tatgtcttta ggtatcgcta aaggcgctga gatcacaatc 1371901 tctgcttccg gagctgacga aaacgatgct cttaacgctt tagaagaaac aatgaaaagc 1371961 gaaggactcg gcgagtaatg caagaattaa aagggattgg tgcttcagcc ggcatcgcga 1372021 ttgcaaaagc gtaccggctt gaagagccag atttaacggt tgaaaagaaa aacatctctg 1372081 attctgaagc ggaagtaagc cgttttgatg aagcgattgc acgttcaaaa gaagagctcg 1372141 aaaaaatcaa agagcacgct ttgaaagaac tgggtcagga taaagctgat attttttctg 1372201 ctcacctttt agttctcagt gaccctgagc ttctgaaccc tgtgaaagaa aaaatcagca 1372261 ctgattcagt gaacgctgaa ttcgctttaa aagaaacgtc ttctatgttc gttactatgt 1372321 ttgaatctat ggacaacgaa tatatgaaag agcgtgcggc agatatccgc gatgtaacaa 1372381 aacgcgtaac cggccacctg cttggcgtcg aaattccaaa cccaagcatg atctcagaag 1372441 aggttattat tgtagctgaa gacttaacac cgtctgacac agctcaatta aaccgtgagt 1372501 tcgtaaaagg attcactact gatatcggcg gacgcacatc tcactctgcc atcatggcac 1372561 gttctcttga gattccagca gttgttggaa cgaaagctgc tacaggcacg atccaaaacg 1372621 gcgtgactgt tatcgttgac ggtatcaatg gcgatgtcat tattgaccca tctgcggaaa 1372681 ctgtaaaaga gtatgaagaa aaacataatg cttatttggc tcaaaaagct gagtgggcga 1372741 agcttgtcaa tgaaccgact gtctcaaaag acggacatca tgtagagctt gcagcgaaca 1372801 tcggtactcc tgatgatgta aaaggtgttc ttgaaaacgg cggagaagca gttggccttt 1372861 accgtacaga attcctttac atgggaagag atcagctgcc tacagaagat gagcagtttg 1372921 atgcttacaa aacggttctt gagcgtatgg aaggaaaatc agtcgtcgtg cggacacttg 1372981 atatcggcgg agacaaagag cttccttacc tgcagcttcc taaagaaatg aacccgttcc 1373041 tgggatatag agcgattcgt ctttgccttg aagagcaaga aatcttcaga acacagcttc 1373101 gcgcgctgct tcgtgcaagt acatacggaa acttgaaaat catgttccct atgattgcga 1373161 cagttaacga attcaaagaa gcaaaagcga tccttcttga agagaaagaa aagctcgtaa 1373221 aagcgggaca ggctgtatct gacgatattg aagtcggaat gatggttgag attccgtcaa 1373281 ctgcagtcat cgctgatcag tttgctaaag aggttgattt cttcagtatc ggaacaaacg 1373341 atttgattca atacacaatg gcagctgacc gtatgaatga acgtgtatct tacctgtatc 1373401 agccatacaa cccggcaatc cttcgcttaa ttacactggt aattgaagca gcacacaaag 1373461 aaggaaaatg ggttggcatg tgcggagaaa tggcaggaga cgagattgcg attccgatcc 1373521 ttctcggctt aggcttagat gagttctcaa tgagcgcaac gtctatcctt ccggcaagaa 1373581 cacaaatcag caaattgtct aaacaagaag ctgagtcatt caaagagaaa atcttatcta 1373641 tgagcacgac agaagaagtt gtcgcgttcg taaaagaaac attcaagtaa tgtacaaaaa 1373701 ccagacggcc tccggcctgt ctggtttttt tcataagtaa gggtatagaa ggacacaata 1373761 acatggctag gagggatagt atgtcaaacc aatttaacgc aggagatact gtttatgtga 1373821 tctacagaaa tccgcacgcc gccaatgtag cccacataaa ggaagccgaa attgtgcacc 1373881 atccatacca tgaaggcgag ctttccctgt ttatttatga aacctatcat ccattcgcag 1373941 aggacgatgc tgtgtttgca agctatgaag aagctaaatc gctttacaaa gaactgtttg 1374001 atattgatcc gtatgagtaa caaggaaatc attacaactc atatcctttc cgcctagtga 1374061 gaaaagtaac gttagtaaag gaaaaggatg tggcatcatg cagaacccat ttgttccgca 1374121 gcttgtgtat atagaaccga gggcgctgga atatccgctg ggccaagaat tacaagataa 1374181 atttgagaat atgggtattg aaatcagaga aacgacatcc cacaatcagg tgcgtaatat 1374241 ccctgggaaa aatcatcttc agcaatatcg caatgcgaaa tcaactttag ttatcggtgt 1374301 ccggaaaaca ttaaagtttg attcatccaa accctcggcc gaatatgcca ttccgtttgc 1374361 aacaggctgc atggggcatt gtcattactg ctacctgcaa acaaccatgg gatcaaagcc 1374421 gtatatcaga acttatgtaa acgtcgaaga gattttagat caggcagata agtatatgaa 1374481 ggagcgcgca ccagagttca caaggttcga agcatcatgt acgtcagaca ttgtaggaat 1374541 tgatcatctg acacacacgc tgaagcgcgc cattgaacat tttggccaaa gtgatctcgg 1374601 aaagctccga tttgtaacga aatttcatca tgtcgatcac ctattagacg caaagcataa 1374661 cgggaaaacg agattcagat tcagtattaa tgccgactat gtgattaaaa actttgagcc 1374721 gggaacttca cctcttgata agcggataga agcggcagta aaagttgcaa aagcaggcta 1374781 cccgctaggc tttattgttg ctccgattta tattcatgaa ggctgggaag aaggatacag 1374841 acatctgttt gaaaagctag atgctgcttt gccgcaggac gttagacatg acattacgtt 1374901 tgaattaatt caacaccgtt ttacaaaacc ggccaaacga gtgatagaga aaaattatcc 1374961 gaagacgaag ctcgaattag atgaagaaaa gcgccgttat aaatggggcc gttacgggat 1375021 cggaaaatat atttatcaga aagatgaaga gcatgcactt cgagaggcac ttgaatccta 1375081 tattgatacc tttttcccta acgcaaaaat tgaatatttc acttaaacgg gctgttgtga 1375141 tcaacagctc gcttttttat aaaaaacatt tttccattcc atcaaaacgc cgtaattcaa 1375201 tgattcttta tcctccaaat aattgctgac tacacgaata ggtgaacgcc cgcaacggag 1375261 gagaaaggac agcacagggt cgtttttcct gccttccatc acatcttcaa cgtactgaac 1375321 agcgctgatc tcgtgtgcgt atttataata caaaggaatg cggccgccgc cgagaaggcg 1375381 ttccagtctt ttatcaacag tcagctcata catcgtattc atcagccatt ttccgattcc 1375441 aagctttcga taatgaggag aaacagaaat atccactaca tataaagtat ttccatgagg 1375501 ttcatgattt ttaatcgatc cgttgtcagt tgcttgtgcc catgtatgat caggagaatc 1375561 aggctcaaat tgtacaataa gagcagtcat ggaaccgata attctgccat tgatgagcgc 1375621 gcataaagcg ccttccggaa aggttttgat atggctggca agctggtcct ctgaccacag 1375681 caattcctgg ggaaacggag gagggaaaca ttcttcttga agagaaatca gcctctcgat 1375741 gtcagtctca gtgtagtttc taatggtcag agcctcaaat tttctgccgt catgcacata 1375801 catttgtttt agtatgatca tcactctcct tatgttgttt cattataacg aagattgaat 1375861 tttcagtaaa tatattccga ttttcttata atttattttt tgattattca tttttcaaac 1375921 gaaagggccg atatagaaat taggagggga ttggtttgtt taaaaaactt cacatgaaga 1375981 ttgctgtttt tgtttcgatt atgttaatca tcacagttgt tctcttaatg ctgtcttctt 1376041 atttgacgct aaaaccgatg attacagagg atgggaaaaa tacaactcaa aacgtgacgc 1376101 agtcacttga acaaaatatt gaattgcaat taaagagtta tgccatttcg ttatcaagat 1376161 tggctaatgg ggaattaacg catacatttg taacgaaacc aagtaaagaa gcttctcggc 1376221 tgtttcacga tgacattaag caaatcaaag acaacgatga ttatgttgcg atggcttaca 1376281 taggcaccgc aaaaaaagaa atgtttacat atccaaaagc ggatttcgct gaggattacg 1376341 atccaacatc aagaccatgg tataagcttg cagctgaaac cccggatcaa gttgtttgga 1376401 cggaacctta taaagatgtc gtgacaggag acatgattgt tactgcatcg aaagcgatct 1376461 tagacaggca aaaagtgata ggggttgcca gctatgactt gaaactctct gctatccaga 1376521 gtatggtcaa taaacaaaag gtgccttaca aaggatttgc ctttttagct gatgcgagcg 1376581 gcaatctttt agcccatccg tcaaatcaag gaaaaaatat atcaaaggat caaacactgc 1376641 aaaccatcgc atccgagaaa aaagggatac aagatgtgaa tgggaaaatg gttgtgtacc 1376701 aaacgattgg cgagacaggc tggaaggtcg gaacgcaatt tgataccgat caattaatgt 1376761 ggatttcaga taaaatgaat cgggccaatc tttggatatc attgattgcg cttatcataa 1376821 caattattct cagctacttc ctggccaaaa cgataaccgg tccgatacag cagctgatcg 1376881 taaaaacgaa agctgtttcc gcaggcgatt taacagtgcg cgcggaatca aaatctaagg 1376941 atgaagtcgg tattttaaca agagatttca atctgatggt tgaaaatatg aaggaaatgg 1377001 ttgagcaagt gagactctct tcagggaaag tatctgacac ctctgaacaa ctaacggctg 1377061 tggctgccga aactaatgaa acaagcggac aaattgcaaa agcgattgaa gaagtagccg 1377121 caggggcatc ggaacaggct tctgaagttg aaaccattaa tgaaaaatcg gaaagcctgt 1377181 caacgaaaat caggcaaatc gctgaggagg caggcggaat taaagaacgc tcaaaatcgt 1377241 ccgaggatgc aagctataaa ggacttgacg cgctcggcca gctgctgatg aaatcaaacg 1377301 aagccaatat ggaaacgaaa aaggttgaaa cgatgctgct ggatttggaa aatcaaacta 1377361 agaatattga agaagtcgtt acagcgattt caaacatatc tgatcaaacc aacttgcttg 1377421 ccttaaatgc cagtattgag gcagccagag ccggagaaag cgggcgcggt tttgccgtcg 1377481 tagccgatga agtgcggaag ttagctgagc aatcagccct ttctacaaag catatcagcg 1377541 agactgtgaa gcttatccag cttgagacaa aagaggcctc tcacgcgatg gttgaggcaa 1377601 gcagaatgaa tgatgaacaa aacagtgcaa ttcacgaaac tggagaggta ttaaatacga 1377661 taactgcaga aatgcagtca ctggtacaag gtattgatca catttacgcg gaaattcaaa 1377721 gaatgagtga agaacagctt gcgatttctg aagccattca aagcatttca gccatatcac 1377781 aggaatcagc tgccgcagca gaggaagtga acgcatcaac cgatgaacag cttgtcaccc 1377841 ttgataaagt caaacactca acggaaacac taaaacatgc aagccaagag cttatgaaca 1377901 caattgcaaa attcacattg taatccaatt acatccccaa acatcatttg ttttggggat 1377961 tttttatttt ataagatgaa tagatatggt agtctagaaa atgaaggaaa aatgataaat 1378021 tttaactaaa atctaaacga aacatctggg aggaatgacc ttgaaaaaaa caattggttt 1378081 tatcggtctt ggagtaatgg gaaaaagcat ggcatcacat attctcaatg acggccatcc 1378141 tgtattggtg tacacccgga caaaagaaaa agcagaaagc atacttcaaa aaggcgcgat 1378201 ctggaaagat acggtcaaag atctttcgaa agaagcggat gttatcatca caatggtcgg 1378261 ctatcccagt gatgttgaag aagtgtattt cggaagcaat ggaattattg aaaacgcaaa 1378321 agaaggtgca tatcttattg atatgacgac atctaagcct tcgcttgcga agaagattgc 1378381 tgaagcggcc aaagaaaaag cattgttcgc tttagacgct cctgtttccg gtggagacat 1378441 cggtgcacaa aacggaacac tcgcgattat ggtcggtgga gaaaaagaag cttttgaagc 1378501 ctgcatgccg attttctctt taatgggaga gaatattcag tatcaaggac cggctggaag 1378561 cggacagcat accaagatgt gcaatcagat tgcaattgca gccggtatga tcggtgttgc 1378621 tgaagcgatg gcttatgccc aaaaatcagg cctagagccg gaaaatgttc tgaaaagcat 1378681 cacaacgggc gcagccggaa gctggtcatt gtcaaatctt gctccccgta tgctgcaagg 1378741 caactttgaa ccgggatttt atgtgaagca ttttattaag gatatgggaa ttgcactaga 1378801 ggaagcagaa ttaatggggg aagaaatgcc aggcttgtcg ctcgcaaaat ctttatatga 1378861 caagctagct gctcaaggtg aagaaaacag cggaacacag agtatatata agctttgggt 1378921 gaaataaaaa aagattgcct gtacgaaaca ggcaatcttt ttttattatt ttccgatgaa 1378981 ttgttgtgtc cagatgcttc cagactcaac gtaaccaaca ccgatgtgag taaagttagg 1379041 gtttagaatg ttttttctgt gtccttcact gttcatccaa gcttttacta cttcttctgg 1379101 tgtcttttgg cccttcgcaa tgttttcacc tgctgttttg tagctgattc cgaaagattt 1379161 catcatatca aacggtgagc cgtatgttgg gctttggtga tcaaagtagt ttttgtcttt 1379221 catatcctga gattttgcgc gtgcagattt gcttaacgtt tcatcaattt gaagcggttt 1379281 taagccttgt ttttgtcttt ctgcatttgt aagttcaaca acttttttct catatgcact 1379341 tacagatgaa ggtgcagacg ttgttgtgtt tgttttttca gcagttgcgg gtgctttaga 1379401 agcagtgttt tgatcagcag ctgctttttc agtagtcttt tgtgcaggtt ttgccgtttc 1379461 tgtcttttga acatcctgaa ctttcacgtt agattgcttc gcatgttttt gaagaagctg 1379521 cttcatctct ttttcgtttg cagcgtttaa cgttttgata tttgtgttaa tatgcagttt 1379581 tttcactgca tcgttaagtg acatgttttg tactgtgttc cccgttttta ctgtaaccac 1379641 aggctggcag gagagttctt tcgctgatgc ttgctgtacg cccccgaatg tgaataatcc 1379701 aaccgcagcg gcagcagata aaataaatgc tttcttcatt agttcgtaac ctcctagagt 1379761 tgtttgtttc tacagaaaaa tcataacata gcttttttgt cataaagatt ccagcacttt 1379821 cctttgacaa atagagattg tcattttcgt aaagtaaatc cgttgaatca ctaagaataa 1379881 gggaatcagc ggtatatatg attttatcgt accgttacat agcttccttt tttttgaacc 1379941 gttagttata ttttaatgtg tttttatatt gacagctttt tttactcctt ttcgctgtaa 1380001 caactattac aaaggtgtta caattaatct cagtatatgt aaatatattg aatgatttga 1380061 gaggggtaac cagaagtgac tgaaatagga cgtgaaccaa agaaaaagag caaaggaaac 1380121 agagcaatca gaatgaacct ttttttccta gctgtctttg ttctattcac tgcattaatt 1380181 tttaagctcg gggttgttca aattgttgaa ggcgaacagc atgaagaaga cgctgagaaa 1380241 tcaaatgcaa aaacagctta ctatcctgcg cctcgcggga agatgtacga cagaaaccag 1380301 aaagttgctg tcgacaacca gagcgttcca gaaattgtgt atgtatcaac atctagcaca 1380361 aaaacagaag ataaaatcaa aacagcgaag cggcttgctt ctttcattca tattgatacc 1380421 gaatttttga aggaaaggga tcttcgtgat tactggatcg cagctcatcc gaaaaaagcc 1380481 gccgctctgc ttaaggaatc agaaagcaat ctgaaaggag accaggctta caagcttcaa 1380541 atagagcgtg ttccggatca agaattaaag gctattcagc aagatgacga agaaatggaa 1380601 actgctgcga tatatacaag gttttcaagc ggaaatgctt acgaacctca aatcgtaaag 1380661 gcaatgaatc caaataagag caatagcaat ggaaaaaacg gagcgctgct tgatgagaag 1380721 aaaaactcct cgcaaagacc aaaaaatgac ttaacatatg atgaaatttc cattgtttct 1380781 gagcatttag aagaacttcc gggaatcgat atcgtaaacg attggacacg aaaatatcct 1380841 tatgacaaaa ccctttattc tgttttcggg ggcgtcacga cacctgatca gggcctgctg 1380901 agcgaccgga aagatttcta cttaacaaga ggctatgcga ataatgacag ggtgggaaaa 1380961 agttatttag agtatcaata tgaagaatat ttaaattcgc ataaagaaaa agtggaatac 1381021 gtagaagata ataaaggaaa tgtcgtcagc caaaaaacca ttgataaggg cagcagggga 1381081 tacgatcttc agctttcttt tgacatggag cttcaggcaa aggtagaaaa gatcattgaa 1381141 gaagaagtaa gaaacagccg tgcacgcgga aattacatgc ttgacagagc ctttgccgta 1381201 atgatggacc cgaataacgg cgatatttta tcaatggcag ggaaaaagat agatttaaaa 1381261 accaacaaaa ttgaagatta tgcgataggg gcatttacca cccaatatga aatgggatca 1381321 gcagtaaagg gggccaccgt gctagccggc tatcaggacg ggatcccgca ttataaatat 1381381 tatatcgatg ctccaatgct tttaggaacg aatcttataa aaaaatctta tactaatatg 1381441 ggaaccatca atgaattaac cgcattgcaa aaaagttcaa acgtatatat gttcaatgtt 1381501 gccatgcata ttgcaggcgt aacatacaag ccgcatggat ctctcccggc tgatcagaac 1381561 gatctactga aaatgagaaa ctattacagc cagtttggtc tgggagtaaa gacaggtatt 1381621 gatctcccgc aggaatcagc cggaatgcaa accacaccta aaactgtagg aggattaatt 1381681 ttagacttag caattggcca atacgataca tacacaccgc ttcaaatggc tcaatacatc 1381741 tcagtaatcg ccaatggtgg ctatcgtgtt cagcctagaa tcgtcacaag tattcataag 1381801 ccaggaaaaa aagaccagct gggtaaggcg attgaacata ggaaacctaa agtactcaat 1381861 aagattaata attcagagag cgatttgaaa caagtacaaa caggcatgaa attagtcact 1381921 tcttcaggga cagcaaaaaa tacgtttaca gaagatgtat cagggaaaac gggaacagcg 1381981 gaaacatttt actacggcac gaatcgcaac tggtggggga aaaaaacata caatctgact 1382041 tttgtcggct attacccgtc gaaaaaacca aaagtggcct ttagtgttgt tgttccatca 1382101 gtagatgatg atgataagat caataaaatt attgccaaaa gagctatcca cgcctacgca 1382161 gagctcgaaa aaaaacacag taaaaaataa aaaacagggt gcacaactaa aagattgtgt 1382221 gccctttctt ttattcaaaa attgacgttc accataagaa tagaaggaga atactcattt 1382281 tctagcgaat catactaggt aaaagtcaat ctgtatatgt cgaaacacga tgatcatgca 1382341 aaggagggat tctgtggaac aggatacgca gcatgttaaa ccacttcaaa caaaaaccga 1382401 tattcatgca gtcttggcct ctaatggacg catcatttat atatctgcca actccaaact 1382461 gcatttgggc tatctccaag gagagatgat cggatcattc ctcaaaacgt ttctgcatga 1382521 ggaagaccaa tttttggttg aaagctattt ttataatgaa catcatctga tgccgtgcac 1382581 ctttcgtttt attaaaaaag atcatacgat tgtgtgggtg gaggctgcgg tagaaattgt 1382641 tacgacaaga gctgagcgga cagaacggga aatcattttg aaaatgaagg ttcttgaaga 1382701 agaaacaggc catcaatccc taaactgcga aaaacatgaa atcgaacctg caagcccgga 1382761 atcgactaca tatataacgg atgattatga acggttggtt gaaaatctcc cgagtccgct 1382821 atgcatcagt gtcaaaggca agatcgtcta tgtaaacagc gcgatgcttt caatgctggg 1382881 agccaaaagc aaggatgcta ttattggtaa atcgtcctat gaatttattg aagaagaata 1382941 tcatgatatc gtgaaaaaca ggattatacg aatgcaaaaa ggaatggaag tcggaatgat 1383001 tgaacagacg tggaaaaggc ttgatggcac acctgttcat ttagaagtga aagcatcccc 1383061 gaccgtctac aaaaaccagc aggctgagct gctgctgctg atcgatatct cttcaaggaa 1383121 aaaattccaa accatcctgc aaaaaagccg tgaacgatat cagctgctga ttcaaaattc 1383181 cattgatacc attgcggtga ttcacaatgg aaaatgggta tttatgaatg aatcgggaat 1383241 ttccctgttt gaagcggcta catatgagga tttaattggc aaaaacatat acgatcagct 1383301 gcatccttgc gatcacgagg atgtaaaaga gagaatccaa aacattgccg agcaaaaaac 1383361 agaatctgaa attgtcaagc aatcctggtt cacctttcag aacagggtca tctatacgga 1383421 gatggtctgc attccgacga ccttttttgg tgaagcggcc gtccaggtca ttcttcggga 1383481 catctcagag agaaaacaaa cagaagaatt gatgctgaaa tcggaaaaat tatcaatcgc 1383541 agggcagctc gcggcgggaa tcgcccatga gatccgcaac cctcttacag cgatcaaagg 1383601 atttttacag ctgatgaaac cgacaatgga aggcaacgaa cattactttg atattgtgtt 1383661 ttctgaactc agccgtatcg aattaatact cagtgaactg ctcatgctgg cgaaacctca 1383721 gcaaaatgct gtcaaagaat atttgaactt gaaaaaatta attggtgagg tttcagccct 1383781 gttagaaacg caggcgaatt taaatggcat ttttatcaga acaagttatg aaaaagacag 1383841 catttatata aacggggatc aaaaccaatt aaagcaggta ttcattaatt taatcaaaaa 1383901 tgcagttgaa tcaatgcctg atgggggaac agtagacatt atcataaccg aagatgagca 1383961 ttctgttcat gttactgtca aagacgaagg ggaaggtata cctgaaaagg tactaaaccg 1384021 gattggagag ccatttttaa caacaaaaga aaaaggtacg gggcttggat taatggtgac 1384081 atttaatatc attgaaaacc atcagggagt tatacatgtg gacagccatc ctgaaaaagg 1384141 cacagcgttt aaaatttcat ttccaaaaaa ataaaaacaa cggcttaaac gccgttgttt 1384201 atcgtctgca ttgcttcacg tttttttaat acaaataatt ctaaacggtc taggccttct 1384261 ctcagcgtgt ccattgagca tgcaaaagac agccttacat atccttcacc atatgttgag 1384321 aacgagctgc ccggcacgag tgccacgcca gcgtcttcca aaagagccat actaaaatca 1384381 aatgaagtca ttccaaatga tttaatagaa gggaagatat aaaacgcacc ggacggttta 1384441 actacgtcaa gtcccatgga aacaagacgg tcataaacat agtccagacg ttttttgtat 1384501 tgttctctca taatcaatgc atcgtcaaag ccgtttgtga cagcttcaag cgcggctttt 1384561 tgagaaatgg atgaggcgca cgacacattg tattgatgaa cctttaaaat gtgctttgca 1384621 atgtctttcg gtgcaaataa aaatccaatt ctccaaccgg tcatgctgtg tgattttgac 1384681 aacccgttaa tgacaatcgt ttgatcccgc aaataggttg cgatggagta atgcggtctg 1384741 tcatatgtta attcactgta tatttcatca gacaatacga agacatttct gccttttaag 1384801 agagctgcga tgcttttcag ttcttcttca gataaagtca cgccggtagg gtttgacgga 1384861 taaggaagca cgacacactt ggtgttgggt gtcagagcat cttcaatcag ccgggcggta 1384921 agcttaaagc cgtgtgacgt agtatcaaca atgacaggct tggccccgca caaattgata 1384981 ataggttcat agcccggata aataggccct ggcataatga cttcatcacc gggagataaa 1385041 atcgtccgga atgcagcatc aatggcttgg cttgcgcctg ttgtgatgat aatttcagat 1385101 tcagcatcat agttgaaatc cgcttttttc ttcatataaa gctgcacagc ttgtctcagc 1385161 tccaggtagc cggcattcgg agtatatgac gtcacgtttt catcaatggc tttttttgcg 1385221 gcagctttca catgatgcgg tgtgaaaaaa tcaggctggc cgattgtaag tgaaatgacg 1385281 tcttcgtgtt gggctacaag attcgagaat ttgcgtattc ctgaaatttc gatctctctt 1385341 gctttcggat tcagcaaatg ttccataatt catcacctta acaaatataa tgagtttatc 1385401 ctattttacc actagctgat catttgtcac ctttttaact gatatatttc gattgtatgc 1385461 gccttttttc taaacatacc tttcttttca gaaaaaaaga agacaaccag cgatttgatt 1385521 gtctttattg tatcatgttc tattattgtt tatatgtgcc aatttcatta atagccataa 1385581 tcaaaatgaa ggtcttcgtg ccaaatcaga tacggaggat gctcttcttg aaggtcagct 1385641 gattctttct tcatattcag gtaagtttct tcactgatat cctctaaaac agtcatttcg 1385701 ttttctttaa atattactaa ggtacccatt atttacaccc ttctttggaa aaatccttga 1385761 ctattttatc actgttagtt ggaaagtcaa tggttattag gaaaaaagtt tcttttttga 1385821 ggaacgcggc ttgttgcctt cggaattcga ttttgaagag ctgccattca ctttttacaa 1385881 attacgccga tatatacagt acaatactga atgcgaatag cgagggattg aattgtcgtt 1385941 acaacaatac gaaattttat tggattctgg tacaaatgaa ttagaaattg tgaagtttgg 1386001 cgtgggtgaa aatgctttcg gaattaacgt catgaaggta agagaaatta ttcagcctgt 1386061 cgaggtgaca tcagtgcctc actcccatca gcatgtagaa ggaatgatta aactcagagg 1386121 agaaatcctc cctgtgatca gtctcttctc attttttgga gtagagcctg aaggatcaaa 1386181 agatgagaaa tatatcgtga ctgaatttaa taaacggaaa attgtttttc atgtcggctc 1386241 tgtttctcaa attcacagag tatcctggga agcgattgaa aagccgacat cgttaaatca 1386301 aggaatggag cggcacctta ccggtattat taagctcgaa gacctgatga tctttttgcc 1386361 tgactatgaa aaaattattt atgacattga atcagattca ggtgttgaca cgtataatat 1386421 gcataccgag ggcttcgatg aaagaagaac tgataaaaag cttatcattg tagaggactc 1386481 accgcttttg atgcgcctct tgcaggatga attaaaagaa gcagggtaca acaatatcgc 1386541 ttcgtttgaa aatggaaaag aggcatatga atacattatg aaccttgctg aaaacgaaac 1386601 tgatttatca aaacagattg atatgatcat cactgatatt gaaatgccaa aaatggacgg 1386661 acacaggctc acaaagctgc tgaaggaaaa tccgaaaagc tcagatgtgc cggttatgat 1386721 tttctcatcg ttaattacgg atgatctgcg tcaccgcggc gaagttgtag gcgcagatga 1386781 gcaaatcagc aagcctgaga tcagtgattt gattaaaaaa gtggatacgt atgttattga 1386841 ataaataaaa acagccgttg ccagaaagag gcacggctgt ttttatttta aaagtaactc 1386901 tcgccaagtt ttttaaagac cggtttatgg taagctggct gctggcgatt tggcactagc 1386961 ggcttttctt tcatgccgac atattcttgc aataggtgtt tcgcttttgt taaagacatt 1387021 tgagctttag gatttcgata cgattgatta agtgtaccta aatgcggaag atgttcgaag 1387081 tcttctttag ttggaggcat gtgaaaatag tagtctccga ttgagataag cacgtccgat 1387141 tgctgttggc tgaaccttgg attttttgaa aaatgaagcc ctattttctt tcctttacct 1387201 tctttgacaa gcttttgcaa agcccgtttt ttcagcagat ataggtattt agggttgggg 1387261 gcggtttttg catggcggtt cacagtgtaa actgcttttg aaagattttc tacggttggc 1387321 tgcagatctt tcgtatatgc atggtcgtcc attatttctc tcctttgctc ttatcaattt 1387381 ctatatgttt agattatact tttttaaagt tgaaatgcaa atattgaatg taaaaatgcg 1387441 cttttttcta agaaaaaaag cgcattttta acctgcatta tacagatctt gccttctttt 1387501 tcggctgttc ttgaaatgct tcctgaacat tcacttccac agcctgagca ctgtattttg 1387561 gcagtgcaat aaaataaaaa ataaaaacga gcaggataat aacacccatg ccgtaataaa 1387621 gataatcaat gtttgaaaca aacttaggga ataacagcgc gactaagccg agtgtcaaag 1387681 attgtgcaaa catcataaaa gggtcctgca tgccgcttac acgtcccatc agttttggat 1387741 gaacaatttt tggcatccac cctccgattg caatgttgat cggtccgata cacattccca 1387801 gtgcaaaagc tgccgcgtaa tacacccata aaatattggt gtagccgagg acgaagatca 1387861 gcaaacctgc aatgaaaatc ggtatcgaca ttaaaaagtg cggcttcact tttttagaga 1387921 tgagcgtgcc gattacgctt cctgccagaa gcccaaaccc gagtgcgatc gtaaatacag 1387981 acgtatgcca ctcataacgg tcaggcgcca atccatattt cattgtaaac atcggcaata 1388041 cggcgaatcc tccattgaca aatccaaaaa tgaagaagcc aaaaataaga gatgccagca 1388101 atttgttttt taaaatatag aggatgcctt ctctaaagtc atttattgaa tccttaacag 1388161 aagtctttct ccagctgaat gcaccgtttg gctgtcgggc ttcttttgga atccggcagc 1388221 tgcggatcag cagcccggaa atgataaagc tgacaaaatc aagaataatg gcgccttcaa 1388281 taccgattgt gttgtacata aacgcgccta tgccgactcc aaacaccata aaaatgctaa 1388341 aaagcatctg attaagccct gccgctttcg cataatgctc cttcggcaga atggcttgta 1388401 ccaaactgtt ttctgccgga aagaaaaact ttgttacagc gcttctgata aataagatac 1388461 aaaaaacaag aggaatattg ccggtaaata aagtgaaaaa aagcacgaca gtcaggcctg 1388521 ctctgatcca atcacaattt tctgccacct tttttctatc aaaccggtcc gcgacgactc 1388581 ccacgatcag aaatacaaat atggtcggaa gagaatacat cagctccgcc aaggtcgtat 1388641 atgaaggctg gctgctgaat cggtccagca aaaaaaaagc aaaggccatg ttgcctactg 1388701 tcgtgcccat ttgagaagcg agtgctgcga aaaatagacg aacaaaatta cgatttttaa 1388761 atatatccat aaaaacgctc cttaccctaa aggtcccact ttatcatatt ataaaccgcc 1388821 tgtttttgaa acaaataaga aaacattacc ggttaatcgt gactctcgtt ccgtttggca 1388881 caattgaagc aagttcgatc acgtctttgt tatgcatgcg aatgcagcct ttagaaacag 1388941 ccttaccaat cgaagcggga ttattcgtcc catgtattcc gtagtgctgc tttgaaaggc 1389001 tcagccaata agcgccaaat gggccgccgg gattgcgctg gcggttaata atgtaaaact 1389061 cgccagtagg cgtttgcgtt agtattttac caacggcgat gggataggtt ttcattaccc 1389121 gattatttag ggacagcgta agggtcttcg ctccgattga gactgcgata tgatacggaa 1389181 ttgtataagg gtccggcagt ccggggatga ctatggactg tcccgcggtg agccctgcct 1389241 gcagtgacgg attagcctgg agtaatgcag ccgtgctgat tctgaaatca gccgcgatgc 1389301 tgttcagtgt atcaccttgc ttcacctggt acgtaagcag tttcctcatc ctcctttttt 1389361 acttataagt attgatgagg agcccatcct gctacattaa tttgtgcttt ttaaggtgaa 1389421 gacagtgatt tcaggcttgg caagaaaccg caaaggcagc ctggtcatcc cgaggcctcg 1389481 gtttacgtaa atatgagtgc tgcccgtttg atacattccc tctgtgtaga cttttccata 1389541 tggaggcgta ataatcggtc cgtaaaaagg cagctgaatc tggccgccgt gtgtatggcc 1389601 ggaaagctga aggttcacgg gataatctgt tgttttcaag gctgcatcag gttcatggac 1389661 gagaagaatg gaaaaaagtc tgtcgctcag ccttgaaagg gtgccttcat aatctgggtt 1389721 tcccagcatt aagtcatcaa gcgaagcaat ctcgattttg ctgccatctg cgagtgacaa 1389781 tgtttgatag ccattgcgat ataccgtgaa acctccggcc gtcatcaggc ttttgtaaac 1389841 ggcagttcca tagcctccgt gatcatgatt gccgtaaata caaagcttgc cgaagggagc 1389901 attaagcttt ctcaataatg gaatgactgc ctggtggtgc tggtacgtat caggattatc 1389961 aataatatca cctgtaaaaa caatgagatc aggtttagat tcattaattg taagaatgac 1390021 agtttttaaa tcttcgagag taaagtaatc actcaagtgt gcatcgctga actgcacgat 1390081 tttaaaaccg tcaaatccgt gcgggatgag agagcttttt attgtgtgtt cggttgtctc 1390141 gatcatatgc ggctcgagat acctggcata gccatatccc ccgccggccg ttaaagcccc 1390201 ggcagcaaga gcgccgaaca ttccttttag aaattgtctt ctggacatct ttttcatttc 1390261 aaaccaacct ttaatagagt ttttctatta tatcatctgt atctgataaa aatctcatat 1390321 gagcatgtgc tgacagaggc agggatataa tgatagaata ttattgaatg aataatcatt 1390381 cacaattgga gggataaaca tggaaaaaaa ggcggtaatt attaccggcg ggtcaagcgg 1390441 catgggaaaa gcgatggcaa aaaaacaggc tgaattaggg tggcacgtta tggtgacagg 1390501 gaggaaccat gaggcacttg aggaaacaaa aaaagaaatt cagacctttg agggacaggt 1390561 cgcttgtttt caaatggatg tccgttccga ttccgccgct tcagacatga ttaaagaagc 1390621 ggtaaaagcc tttggccggc ttgacgcgct gattaacaac gcggccggaa actttatttg 1390681 tccggcagaa aagctgacgc ccaatggatg gaaagccgtt attgagattg ttttaaacgg 1390741 cacatttttt tgcagccaag cagcggcaag gcattggatt gaccagaagc agcagggtgt 1390801 cattttaaat atggcagcca cgtacgcttg gggagcggga gcgggggtcg ttcattccgc 1390861 tgcagccaaa gcgggggtat tgtcattgac aagaacgctg gccgttgaat gggggagcaa 1390921 atacggcatt cgtacaaacg cgatagcccc cggaccgatt gaacgaacag gcggtgcgga 1390981 gaagctattt gaatcggaaa aagcgatggc ccgcacgatg aacagtgtgc cgctcggccg 1391041 attgggcaca ccggaggaaa tcgccgcttt ggcagcgttt ttgctttctg atgaagcatc 1391101 ctatataaac ggggattgta tcacaatgga cggggggcaa tggctgaatc cttatccgtt 1391161 ttaatctgaa tatttataag tgaatattta agttattaag aacttttatg ttcgaatgta 1391221 atacctccac aattaacctt cttcctatcc aatttgataa cacatagagc tttatttgtt 1391281 tatgaggtgt tgtgtcatac gtaagccacc taatatatga aaggtatatt ttaaaagggg 1391341 agacgaaata tgaagaactt agatttcaaa taaaacattc atataattac ttcgttaact 1391401 aaaaagagaa attataagaa tgaaaggttt caaggttaca tcagattggg aggaaggtaa 1391461 tataatggac gagatggtat tattaactca ggaatggctc aatgaaacgt acaaaggaaa 1391521 aagtggctac aattccattg aggaaaatgg gaaaactggc tggaaaacaa tgtatgcatt 1391581 aactagagca ttacaactag aattgggaat tacacagact tccgacagtt ttggtcctac 1391641 aactttaaga aagcttaaag aattaggccc gatttctacg tcaactaatt caaaaaaaaa 1391701 tattgtgaaa attattcaag gtgctcttta ttgtaaaggt tatggtccag gtggattaac 1391761 gggtacattt ggtcagggaa cgaaagaggc gatagcagaa atgcaattgc atatggggct 1391821 ttctaaaaca gacggtgtag taacgcctaa ggtgtttaaa gctttattaa acatggactc 1391881 ttatatcctt ttaaatgggg cgtcagagaa agttcgttca atacagcaat ggctaaataa 1391941 taaatattac aatagagaga atttctactt tatgccctgt gatggcctgt attcaaggga 1392001 tactcaaaag tctcttgttt atgcaataca gtacgaggaa gggttaagtg atagtatagc 1392061 taatgggaat tttggaccaa ctactcaaag attgattcct gtattaagaa ttggagaaac 1392121 agatgaaaaa aacagtttta ttcatttatt tcaagctgct ctaatcttta atggctacaa 1392181 tgttcctttt gatggagtat actctgaatc tgtaagatca aaagtaaagg cttttcagtc 1392241 ttttgcaaaa ttacaacaga gtggtactgc cgactttcaa acatgggctt cacttctagt 1392301 aagtactgga gaccccaatc gaaaaggagt tgcttgtgac tcaattactc aaattacatc 1392361 ggacagggcg gagtccctta agagggcagg ttataagatt gtagggcggt atctaacaaa 1392421 tgcgccgggg agtacactaa ataaaaaaat acaaccaggt gaattagaaa ctatcttaaa 1392481 atcaggttta aatgtttttc cgatttatca aacctatggg ggagcaacaa attattttaa 1392541 taaagaacaa ggaaagaaag atgcgtttgc tgcttataaa gcagcaaaag aatacgggtt 1392601 taaaaataac actgtaatat actttgcagt agattatgat gcatatggta acgatttaaa 1392661 caacaatatt attccacact tcgaaggtat aaatgaaata atgaacggtt ttttaggttc 1392721 aacttacaaa attggtattt atgcccctag gaatgtatgt actatagttt ctaaaaaagg 1392781 tttagcattt gcaagttttg taagtggtat gtctactggc tttagcggaa acttaggata 1392841 tcctttgcct tacaattggg cgtttgacca aatttcaaca attactgttg gaaatggttc 1392901 tggaatgatt gaaattgata atgatatttg ttcaggtttg gataatggag ttaataccat 1392961 aaatatagtg ccttcagaga ataagaagtt ttttgatcaa attgatgttt tatatgaaac 1393021 tgctgaaaaa tatgctcaaa tgcaaagcga cttaaataat ggggtaaaaa aaacacaatt 1393081 agctaatgag ttggttgccc agtatttaag aaaggatgac tacaaagggt ggaagtgggt 1393141 ccctaccgca ggccagattg atcctattta tcgtgaatgg gcagtaaagc gctaggggaa 1393201 gacctagtaa atggaattgt tgatcctata tcaaaaactg tcataggaac gcagcatctt 1393261 atggcaactt ataatgccat tatttatagt ggtggttact ctcaaacact acgagatttt 1393321 gctggttgga ctggagatct attaacaaca atacaggaca tgaaattaca cgctcaagaa 1393381 tttaattcgc cttatgatgc ggctatgaaa ataataggta atatgtatca atttagccta 1393441 gatgatttat ttagtgatgt agatgcaatt aatctagcga ataaaacatc agttggtgct 1393501 aatgcacaac ctctaaatat cgcaattaga gattattata gtaataatga ctgtatgaat 1393561 aggttcactc aatttgtaaa taatagattt gatggttcgt tagacaaaat tttctctgaa 1393621 gcagagtatt atttaaatac aaaccttgac ccagttgttg ttccaattag gttagccttt 1393681 aaacgtgctt ttgatgttga ggattatagt gaagagattg gaaaaataac agcacaagca 1393741 tttagagatg ttatcgagaa aaaaatgata tctgaataaa ctgcaaaaca agcgaacgtt 1393801 aaaactggtc gttcgcttgt tttattttct atttaaattt atgatataat ttttaaagat 1393861 taaggagtga ttcattgaag aaattgttaa aaaagttagt tgtattattt ttaagcagtt 1393921 tagttatcat ctttaatgtt tggtacttta ttatttgtgc tttttcccca gagtattatc 1393981 aaaatacaaa tcttacttct aatgaaataa taagatttga aaaactatac cacatagatt 1394041 ttcctgatga aacaaaattt attaaagcta gagagtattt ggctgggccc ggaggagata 1394101 cgtcagctgt attatatgtg tctctgccaa ccaagcgggt agaaaaagtt ttatctgatt 1394161 acacgtatat gaaaataaac tatactgaca atgtcggttc aatgtatgga gttgacgttt 1394221 caaagagtgt cgccggttta acaactctta catttggcac ttacgataaa aaaggaactt 1394281 tctataatat gaaacatgat gatgattgga tgtataaagg cactgactgg aatctttact 1394341 tttggacagc tgctagttat aatgctgtta tttttgtatt tgttttggtt attgtgaaac 1394401 aaatgaataa aattcttaat taaccagtat gtagattgat aatctcaaaa aaattttcct 1394461 cttcttttaa catactccat acgacctact tttccatact atgatttttt tgaaatttgt 1394521 ggtgtagtta taattgtgcg tataatcaga caaagataga gaagcaggtg ataacatgtt 1394581 ggatccactt gatattttaa cgaacattga tgatgtcctt ccatattacc aggcgatttt 1394641 tagtgccgag gagcagaagg ttgtcggata tgaggtgctt ggacgaattt tggcagattc 1394701 agaaatccaa agtctcgggc ccttcttttt agatgcgggg atacccgaag aatataaatt 1394761 agaggttgat aacagaatta tccgccaggc tcttgaccgc tttttagagg cggattctga 1394821 tctgctgatt tttatgaatc aggatgccaa tctgctgatg ctggatcatg gtgaaagctt 1394881 tctggagctt ctgaaagaat atgaagcgaa gggaatcgaa ctccaccgtt ttgtgcttga 1394941 aattacagag cacaattttg aaggggatat tgagcagctc taccatatgc ttgcatacta 1395001 tcgtacatac ggaattaaaa tcgcagttga caacatcgga aaagaaagca gcaacttgga 1395061 cagaatcgcg ctgctctcac cagatctgtt aaaaatcgat ttgcaggcgc tgaaagtgtc 1395121 acagccgtca ccgtcatatg agcatgtgct gtacagcata tctttattag caagaaaaat 1395181 cggtgcggcg ctgctgtatg aagacattga ggcgaacttc cagcttcagt acgcctggag 1395241 aaacggaggc cgctattttc agggctatta cttagtgtct ccatctgaaa cgtttctaga 1395301 gagagatgta ttgaaacaaa gacttaaaac tgaatttcac caatttatca cacatgagaa 1395361 aaagaaactg gagaccgtct atgagcactc tgaacagttt tacaaacgag tgcatcaggc 1395421 tgtgacctct ttgagaaaaa acaatctgtc ttctgatgat gactttatta aaaagctggc 1395481 ggaagagctg acagattgca gcttcaggat ttacatgtgt gatgaagaag gcgatcagct 1395541 gacgggaaat gtgtttaagc aagatggaga atggatttat cagccggaat atgcggaaaa 1395601 gaactggagc tggcgccctt attttctgga gaacattatg agaatgagaa atctcagaaa 1395661 aggttttttc agtgatctgt acagtgattt ggaaacaggt gaaatgatca gaacgttttc 1395721 atatccgatg gatgatcaga tgtatttatt tatagacttg ccttattctt atttatatga 1395781 gcaggacgga ctgatttaac ggctgaaagg ccgttttttt tatgaaatga aaaaaatatc 1395841 aaaaaacgat tgacattgat actgagaatc attatcattt aattatagag agaagctact 1395901 ctctgttccc caacccctct atcagatcaa gatccgaaaa aacttggcgc tacccccgcc 1395961 aagtttttta tttgtcaaag cataggacaa tccaatgaaa caataaacct aactagtggt 1396021 aaacgtttaa cacggggaga aacattgagt gccgaacacc cctgacactg ctgcacgggt 1396081 gaggaggaaa attcgttctg aaatgattat ttcagttccg ttgtttacct ctatccagca 1396141 tgactcccat tgattatggc cacgcgggac ttcaccataa aattcaaaag aaggttttga 1396201 caaagttgca aaaaggcatt cttaatgctg ccaaagattc gaaaaaaatt ataattatgt 1396261 gcatgacatt caaaaaaagc ctcaaactaa agaaaaatag tttttttcac tttttttctt 1396321 tgcttaaatt cagcagtgaa aatgccatcc tgtccgactt tatggtatga tgctcaatag 1396381 aacttgtatt ataataaata cttgttgatt tgaagttgct ttttgaaagg agtctttttt 1396441 tagaatgtca caattaatgg gtatcatcac acggctgcaa agtctgcaag aaacagcgga 1396501 agcggctaac gagccaatgc agcgttattt cgaagtgaat ggtgagaaaa tatgcagtgt 1396561 taaatatttc gaaaaaaatc aaacgtttga actgacggtt ttccaaaagg gtgaaaaacc 1396621 taacacatat ccgtttgata atatcgacat ggtttccatc gaaatctttg aacttcttca 1396681 gtaagattcc tgaaataggg ggaacaagct tccgcctttg caaaagtaat cgaaataaac 1396741 ggtaaggaac atacttgttt catggttgta aatccttgaa aaggagtgtc gtgatggctg 1396801 attcttttct gttttataat ctttcagaag cacagatgac ctttcaagat gtgatggaac 1396861 ggcttaaagc ctttgttcaa aaggaccccc gttcttctta tgtgttatcg atcggaaccg 1396921 attcacaggt ttaccgcgat tacacaaagt ttattaccgc attgcatttg catcgtacag 1396981 gcaagggagc ttggggctgc ttgaaaaatc atacagtcga cagacccata catagccttc 1397041 gggagaagat ttcgttagaa acggcgtaca gccaagaaac ggccgctcat attcttgatg 1397101 gacacttaat ggatattacc gatctgctcc tgccctttac cggtgagggg gcggatctta 1397161 cctttgaagt tcacttggat attgggaaaa aagggcttac aaaagatctg atccaagaaa 1397221 tgactggacg tattacctcc atggggattg aggccaaaat aaagccggat tcatacactg 1397281 ccttcagcta tgcaaatcgt ttcacaaaat aatttggctg aaaaagccaa ggtaaatgtc 1397341 gaattatgcg gttgacgttt gttatctgat tacttattct agcggtagag ctgaaagtaa 1397401 gttgtcttgc tttcagaggt attcagtata aaacaggggg cctgattgcg aatgagtctt 1397461 atcggtgaac gatttacaga agaagaacaa aaacttctgc tgaatatcct gatcaaccat 1397521 gagtatgcca tcgagctatt aagcagtgag atcaacgata tagagacagg gaccaaaaac 1397581 gttgacggaa ccacctacaa aaaacttgta acgctatacg accgatttcg atttgaaaat 1397641 taatgggaca ccctataatt gatactccac aaagagtatc ttttttattg aaaggaaact 1397701 tttcgacaaa tactgataaa gtttatatta ttgcaatata gggaatgtat tgatgatgaa 1397761 aatgaaaagg ggtcgaaaac atgataagct tacaatcaga tcaacttctt gaggcaacag 1397821 tcggacaatt tatgattgag gcggacaaag tagcgcacgt gcaagtcgga aataaccttg 1397881 agcatgcatt attagtattg acaaaaaccg gatacacagc catcccggtt ctggatcctt 1397941 cctaccgttt acatggctta atcgggacaa atatgatcat gaacagtatt tttggacttg 1398001 agcgaattga gtttgaaaag cttgaccaaa tcactgttga ggaagtcatg ctgaccgaca 1398061 ttccgcgcct tcatatcaat gatccgatta tgaagggatt cggcatggtc attaataacg 1398121 gatttgtctg tgttgaaaat gacgagcagg tatttgaagg gatttttacg agaagagtcg 1398181 ttttaaagga attgaataag catatacgct cattgaataa gtaggctgta cggtcctatt 1398241 tttattatat aggcagagtg aaaaaagaaa gcgcatacat aatttaaacg agaatagggc 1398301 ttgaataaga aactaagatt ttattagaat gggagataag aaaaacttat tgataacaaa 1398361 aaggaggacg acatgcagct tcaagagctt catatgctcg tagttttagc tgaggaatta 1398421 aatatgagaa aggcggcaga acggcttttt gtatctcagc cggctttatc tcagcgctta 1398481 caaaccattg aaaaggcgtg gggaacaaaa atctttttaa gatctcaaaa aggattaacg 1398541 gtaacgcccg ccggtgagaa aatcattcag tttgcgaatg atgtgacatt agagcaggaa 1398601 agaataagag aaaatattga cgagcttgaa ggtgaaattc acggcacatt gaagcttgcc 1398661 gtcgcctcca taatcggtca gcattggctc cctaaagtcc tgaagacgta tgtggaaaag 1398721 tatccgaatg caaagatctc gctcataacc gggtggagca gcgaaatgct gaaaagcttg 1398781 tatgaggatc aggttcatat cggcattata agaggcaacc ctgagtggaa ggggcgcaaa 1398841 gattacttaa tgacagatca tctgtattta gtggatactg aaatttcctg catcgaagat 1398901 attgcccata cagaacgtcc gtttatccag tttaaaagtg acagcactta ttttcaggaa 1398961 attcagcact ggtggcatca aaaatttaaa acgtcgccga aacagacgat attggttgat 1399021 cagattgaaa cgtgcaaaca gatggcgctg cacggaatcg gttatgccat tttgccgtct 1399081 gttacccttc aaaatgaaga taaagtgaat aaaatgcctc ttttagacat gaaagggcat 1399141 ccgatcggtc gggatacatg gttattaggt tatgagcctg cctttgaact gaaacaagtt 1399201 caagcttttg tacaagtgat aaaggatatg ctggatcagg aaaatccatt ttaaagacag 1399261 cgaggtgctg tctttttttt atttatctgt tgacaatgaa aatcattatc atttaaagtg 1399321 atacatatga tattgaaaat cattatcaac taatggggtg ataacatggc taaagccttg 1399381 attacatatg ccagcatgtc aggaaataca gaagacattg ccttcataat aaaagatacg 1399441 cttcaggaat atgagttgga tatcgattgt gtcgagataa atgatatgga tgcgtcttgt 1399501 ttaacctcct atgattatgt actgattggc acctatacat ggggggacgg cgatttgccc 1399561 tacgaagcgg aggatttttt cgaagaggtc aaacagattc agcttaatgg tttaaaaaca 1399621 gcctgcttcg ggtctggcga ttattcttat ccaaagtttt gcgaagcggt gaatttgttc 1399681 aatgtcatgc tgcaagaggc gggagctgct gtttaccagg aaacactaaa aattgaatta 1399741 gcgcctgaaa cagatgaaga tgtggaaagc tgccgagcgt ttgcgagagg ttttcttgca 1399801 tgggcagatt atatgaacaa ggaaaaaatc catgtttcat aaaggggcaa ccgctgttac 1399861 ggcatcggcg ttttctggat attttgtggc ggtacaaaga gaaggcattt ttcattactc 1399921 tttggagcag ggctggagaa agctttttcg tttgaaaagt aagatacact gtatcagcta 1399981 catagggcct tacttatttg gcgttggtga aaagggaaca gtcattcgtt cggctgatga 1400041 agggaaaacc tggacgatgt cgagctttcc gacaaatgca acagtgtggg cgattaccgg 1400101 cagaaacaac gggtttgtct gcgcccacgg taagcattgt atttatgtat cggatgattt 1400161 tggtgtctca tggcgcgtag ccaaaccttt tgccgaattt cataatcccc ctgttatccg 1400221 gtcgttatgc cttcacgggg gcaatctctt tatcggcacg caaatacacg aatattttgg 1400281 cggcatttgg gcttacgaca ttaagcgtga cactgtccaa gttgtcaaaa aagaaaaaaa 1400341 ccggatgacg gcatccatgc tcgtgttcaa tgaaaattgg ctggtggcgg cgatgggttc 1400401 tgtgaaagga aagcacggtg ctgtcactgt aaggaatctt ttgaatggtg aagaattcac 1400461 catacaatcc agtatgatca gaaatgaaga atcatttctt gatctttcag aggatgatgg 1400521 cattatatat gtcactacaa cacaagatga aaatggtttt tcgagaattt accaggttga 1400581 tctcgaagcc cggtcgttaa aatggttcga taccattaag ggacatggat ggagagtggc 1400641 caatcagaaa gagaatttct tttgcgcagg cttgtatgaa tgtaaatttg tccagccgta 1400701 cgaagtttca gcaatgattc attagaggag gaacaaggaa ttggcgaaga ttttgctcgt 1400761 ttatgcaaca atgtcaggca acactgaagc tatggcagat ttgattgaaa aggggcttca 1400821 ggaggcgtta gcagaagtag accgtttcga agcaatggat attgatgatg cccagctgtt 1400881 taccgattat gaccatgtca taatgggaac ctacacgtgg ggagacggag atctgcctga 1400941 tgaattttta gatcttgttg aagacatgga ggagattgat ttttccggca aaacatgcgc 1401001 tgtattcggt tccggtgata cagcatatga atttttctgc ggagcggttg atacgctaga 1401061 ggcaaaaata aaagaacgcg gtggagacat tgtgctgcct tcggtaaaaa tcgaaaataa 1401121 tccagaaggt gaagaagagg aagaattaat aaacttcggg agacaattcg caaagaaaag 1401181 cgggtgcgct gtctgatcac tcactgggaa ctgctaaaac ggctgttcct ttttttcttg 1401241 tctttgtatc tttcctttga tacagtaatg aggtagaaaa tcaggaggag gactatacat 1401301 atgaaaatga tggacgcaaa tgaaattatt tcatttattc aaaatagtac aaaatctaca 1401361 cctgtaaagg tttacgtgaa aggtgagctg gaaggaatca atttcggtga atctgcgaaa 1401421 gcttttatca atggaaacac tggtgtcgtt ttcggtgaat ggagcgaaat ccaaacagca 1401481 atcgaagaaa accaaagcaa aatcgaagac tatgtggttg aaaatgaccg ccgcaattct 1401541 gcgatcccaa tgcttgatct taaaaacatc aaagcgcgta tcgagccggg tgcgatcatc 1401601 cgcgaccaag ttgaaatcgg tgataacgca gtcatcatga tgggtgcttc tattaatatc 1401661 ggttcagtca tcggcgaagg cacaatgatt gatatgaacg ttgtgcttgg cggacgagct 1401721 actgttggaa aaaactgcca tatcggcgcg ggttctgtac ttgcgggcgt tattgagccg 1401781 ccatccgcta aaccggttgt gattgaagac gacgtcgtaa tcggcgcaaa tgctgttgtg 1401841 cttgaaggtg taacagtagg taaaggagct gttgttgctg cgggagcgat cgtggtaaac 1401901 gacgttgagc catacactgt cgttgcaggc acaccagcta aaaaaatcaa agacattgat 1401961 gaaaaaacaa aaggcaaaac tgaaatcaag caggaattac gccagctgta aggaaaagtt 1402021 tgataaaaaa ggcgtggata atatatccac gccttattcg tataggcagg aggaatagaa 1402081 atgaagatag aggagctcat cgcaattcgc agagatctgc atcgtatacc ggagcttgga 1402141 tttcaggagt tcaaaaccca gcagtattta ttaaatgtct tggaacaata tccgcaagac 1402201 agaattgaaa ttgagaaatg gcgaacaggg ctttttgtaa aagtgaacgg gacggcgccg 1402261 gaaaaaatgc tggcatacag agcggatatc gatgcgcttt ctatagaaga gcaaactggt 1402321 cttccattcg catcagagca tcacggcaac atgcacgcct gcggtcacga tttgcatatg 1402381 acaattgcac tcggcattat tgatcatttt gttcaccacc cagtcaaaca tgatttgctt 1402441 tttctgtttc agccggcaga ggaagggcct ggcggtgcgg aaccaatgct tgagagcgat 1402501 gtattaaaaa aatggcagcc tgatttcatc actgcccttc atattgctcc agagcttccg 1402561 gtaggcacca ttgcgacaaa aagcggcctt ctatttgcga atacatcaga gctagtcatc 1402621 gatctggaag gcaaaggggg acatgcggca tatccgcatt tggctgagga tatggttgta 1402681 gcagcaagta cacttgtcac ccagctgcaa acgattatct ctagaaacac agatccgcta 1402741 gacagtgctg ttattacagt tggtaccatt accggaggct cggcacaaaa tatcattgca 1402801 gaaacggccc acctggaagg cacgatccgc acgctttctg aagaatcgat gaaacaagta 1402861 aaggaacgga ttgaagatgt agtgaaagga atcgaaatcg gattccgctg caaaggaaaa 1402921 gtgacatatc cgtctgtata tcaccaagtt tacaatacga gcggattaac agaagaattt 1402981 atgtcttttg ttgctgaaca tcaactggcg acagtaattg aagcaaaaga agcaatgact 1403041 ggagaggatt ttggctatat gctgaaaaaa tatcccggat tcatgttctg gctcggcgct 1403101 gattctgaac atgggcttca tcatgctaag ctgaatcccg atgaaaatgc gatagaaaca 1403161 gcggttcatg tcatgacagg ttatttttct gtttatgcca attaagtaca aatgaaagaa 1403221 taaaattcca taaaatgagc actctagtaa acggaggtgt tcaaaaatgg ctaaaaaaat 1403281 tggaattgaa caatcgttat cagatgtaga agctgcttta aaagaaaaag gatatgacgt 1403341 tgtaatgatg aaaagccctg ctgatgctca aggctgtgac tgctgtgtcg taacaggtct 1403401 tgataataat gtgcaaggga tagccgatac ggtaacacaa gcacctgtca ttacagcttc 1403461 cgggatgacg gctgaagaaa tttgtagcga agttgagagc agaattcagt aataaaaaaa 1403521 ccgaagcaaa aagcttcggt tcttttattt attctgtttc tttagggaaa gcgcggtcga 1403581 acgcgttctt tatttctttt ctcaacactc gttcgactcg ccactgttcc atattttctg 1403641 ttttggcaat gaccctgatt acaatttcag aagtccccag ttcttgaatc ccgatgacat 1403701 ttgggccttc ttttatttgt ggaagagccg ctgccgtttc atcacaaacc tgctgtaaaa 1403761 tatgaatcat ttcatcaata tttctttcag ccggcacttt aatgtcaaca agagcctgca 1403821 tggtaccacg agaatgattg ctcacgtttg tgatgtttct gttggggatg taatgcagtg 1403881 ttccgtcaaa gctgcggatt tgagttgtcc ttaagccaac ctgctcgaca attccgtcaa 1403941 aggtggaaac ggtaatataa tctccgacat ccaattgttt ctcaagcaaa ataaaaaaac 1404001 ctgtcacgat atcactgaca agcccttggg cgccaaatcc gacagccagg ccgacgattc 1404061 ctgcccccgc taaaagagcg cttggatcat aatgaaacaa atctagaacc atgacgaaaa 1404121 atatgaaaat caatgtataa gcaaatatgt taagagtcag gcttcggagc gtatgtgcac 1404181 gtccgataga caagctattc tgctcctcga attttgcaaa cagatgttta atgattttca 1404241 tgcctaatga tcgaacgata aaatagagca atatcataat ggcgagttta atgagcagaa 1404301 caccggcatt tgtaatcagt cccgcccaat catattgttt aataaagtcc atgttgagct 1404361 ccttttctaa ttgattgctg cacattgaga ctagttaccc tgtacatgac catgttaaac 1404421 gttttattca aaaatgtcga agccaaagac atacatgatt tgttaaaaat tgactcagga 1404481 aatctgcttt tatataatgg cattgcaata taactaaaaa tggttaatca ccctttattt 1404541 tcatgcgatt ttgaccttta agccaaacaa taaattggag ggatacatat ggcagaacgt 1404601 atggtaggta aacaagctcc tcgttttgaa atggaagcag tccttgcaag caaagaattc 1404661 ggcaaagtaa gtcttgagga aaacatgaaa aacgacaaat ggacagtgct gttcttctat 1404721 ccaatggact tcacttttgt ttgtccgaca gaaattacag caatgtctga ccgctatgac 1404781 gagttcgaag atcttgatgc agaagtcatc ggggtttcaa ctgataccat ccatactcat 1404841 ttagcttgga tcaatacaga ccgcaaagaa aacggtcttg gccagctgaa atacccgctt 1404901 gctgctgata caaaccatga ggtatcccgg gaatatggcg ttttaatcga agaagaaggt 1404961 gtggctttgc gcggattgtt tattattaat cctgaagggg agcttcaata tcaaactgtt 1405021 ttccataaca acattgggcg tgatgttgat gaaacgcttc gtgttctcca ggcgctgcaa 1405081 actggcggac tctgtccggc taactggaaa ccaggccaaa aaacacttta attctttcca 1405141 agaacgaaaa gcggtctagc atattcgtta ggcctctctt ttaaaatagg agggaaaaag 1405201 caatgaaatt acgtcagccc atgccggaat tgacgggaga aaaagcttgg ttaaatggtg 1405261 aagtgacgag agagcaattg attggggaaa agccgacgct tattcatttc tggtccatca 1405321 gctgccactt gtgcaaagaa gcgatgccgc aagtgaatga atttcgtgat aaatatcaag 1405381 atcagctgaa tgttgtagct gtacacatgc cccgttccga agatgatctt gaccctggta 1405441 aaattaaaga aacagctgct gaacacgata tcactcagcc gatttttgtt gacagtgacc 1405501 atgctttaac cgatgcattt gaaaatgaat atgtacctgc atattatgtg tttgataaaa 1405561 caggacagct ccgtcacttc caagccggcg ggagcggtat gaaaatgctt gaaaaacgtg 1405621 tgaaccgcgt tctggctgaa acggaatagg tatctgacta aatagtattt cctaaaaacc 1405681 tgacctcatc aggtttttta tttgtgcaaa aagcaatgga agaagagtaa gaagcttatt 1405741 tttccaaatt tgggtatagg aattgatgat ttgtttgatt gatacgctaa aaaacacagc 1405801 taatttttga tgtttttcct caattttaga taaatctcat atctcataac tcgaaaattg 1405861 tagatattac actaaatttc tttaaagaag taagtaaaat atatattttc aacattatac 1405921 caaataaact agaaagcccc ttaatccctt gagaataaag gactcttttg aaaaataaaa 1405981 cattttcaga aaataaggaa tttttcatag agtaaatata atagtaaaat gctaaaataa 1406041 tagttgataa aattactttt gtaatctaat atcttaatta aagatgttaa ttttgatagg 1406101 gggtacattg aggaatgttt aatgaaagag aagctttgcg cttgcggtta gaacaattaa 1406161 atgaagctga agtgaaagtc attcgtgaat atcaaattga acgtgataaa atatacgcaa 1406221 aattaagaga gctggacaga aatggaagcc cttccgaaat caaaaaggat ttccgttctg 1406281 aaaaaaaacc tgactctctg ccggttctcg ctgagcttgc ggctcaggaa atcagaagct 1406341 atcagccgca atcacagcag cagtctgttc agcctcagct tcaatctatt tcctctcttc 1406401 ctgccggtat accagacgga acaacacgaa gaagaagagg aacggcaaga ccgggatcaa 1406461 aagcagctaa gctgcgtgaa gctgctatta aaacattaaa acgccacaac gcggcgatta 1406521 agagctcgga gcttcaaaaa gagattgaaa aagaaagcgg tcttgaaatc cctaatatga 1406581 caacgtttat gcaaagctta attaaaatgt acccggaagt gaaaaagcca tatcgcgggc 1406641 agtacatttt agagggtgaa atcgaatctg cagaatcagc aaacgaataa atataaagaa 1406701 aaactgcttg gcatcgctca agcagttttt ttattgaggt tttttctgtg aaggtttgtt 1406761 ttctttttca agattaagct tatacaccca cttttgataa ggcttttctt cagcggctct 1406821 gtttttcagc tcttcgattg tatggctctt ggcctggtct gatgattggg cgtgggcaag 1406881 ctgtttttga agcacatgta tctgtttggt gacatcttca aggatagtct ctacatgatt 1406941 tggctgcgcg taggccgctg gagcttcttc ttccgttttt tctttttgtt tcgtgccgcc 1407001 atcaatatcg gcaaaatgag aagcaatcca ggcatcgctt tcatcaagtt gccgtttata 1407061 cgatataata gtttcgtgaa ataatttttc tttcgttttt tctatgtcta gcagtctttc 1407121 tttcgtttct atgattcgat ctttcatatg atcaacttct attttaatat gttttagctg 1407181 atattctttt tctaccattt gctcttttag acgcccgttt tcggctttta tcaattcggc 1407241 ttgctgtttt gcctgaagca gtgcattttg ttcctgctca attgaggctt gaagttcgct 1407301 gatccgttta tgaagatttt tattttcttc ttcgattttg actttcgcaa tatgaagttt 1407361 atgtttttct tcgatttcgg ctctgcgttt ataggtttca gcagatagaa gctcctgcaa 1407421 aacaacgatt ttatcaagca gttcagctct tatttggtgc agggtttggc tggtgtggga 1407481 ggcatgtttt tcttttgttg acatatgtgt taattcggca gacagctgct ggagtttttc 1407541 tttcatatcg gtattttctt tgagcagttt gttatttttc tgatgaaagt agcttgcttc 1407601 aagttcagaa atcagcttat ggcaccttga aagctcggat tttaaataaa ggttctcctg 1407661 agacacgtcg tggaaaaaag gacctgatct tttcattcga accatctccc tcatgatgtt 1407721 aacactacaa tatgcaaata ctgaacagct attcctcttt aataaacaga caagcagtag 1407781 cgttgagcct ttgcttttgc tatgctttta acgaaactag aggtgagatg atatgaagca 1407841 tgtaaacgta ctgctggcag ggggagcctc acgtcgcttt ggagaaccga aggcgtttgt 1407901 caaatggaag ggcaggatgc tttacgaatg cgctaaagag gcacttggag aacaaacggt 1407961 tatcatcagc cgtcccgaat ttattgatag atttcaagaa aacggtgaaa atgaagtgta 1408021 tcaagatgct gagccatttc aaggcatggg gccattggct ggtatatata ccgcttttaa 1408081 aaagacagac ggtgatcttt atactgttct ttcctgtgac acaccgctga tacaaagaag 1408141 gacgatgctg gagctcaaac gtctgatgat tgccggtgcg gacgcggtag tcccaatttc 1408201 agacggacaa gtgcagccat tgattgcgat ttaccacaaa cgtatcatgc cagttctata 1408261 cgatcagctt tctgagaaga ggttgagaat atcagattta ttaggcagaa tttcggtttg 1408321 ttacgtacag gctgaaaata tcggagcaaa cccggcagag tttatcaaca ttaatacacg 1408381 tgatgatttt agctgtttgg aagaaaaatc gaactccctc aagcgggact gacggggcaa 1408441 taacatgata agatgacata aaagataagg agaacaggtt tgatggagga acgttattca 1408501 cggcaaatca gatttaagca aattggggaa gagggccaga aaagactggc agacagccat 1408561 gtgctgattg tcggagcggg agcgctcggc actgcaggag ctgaagggct ttcgagagcg 1408621 ggagtcggta cgattaccat tattgaccgt gactatgtgg agtggagcaa tcttcaaagg 1408681 cagcagcttt atacagaaag cgatgccaaa ctccgcatgc cgaaagccat ggctgccaaa 1408741 gagcatctat cagcgattaa cagcgagata catattgagg cgtatgttac cgaaggaaca 1408801 gccgaaacgc ttgagccgct gattgaaaaa gcagatgtcg tgatcgacgc gacagataat 1408861 tttgaaaccc gcatgctgat aaacgatctt gcccagaaaa caaagacacc ttgggtctat 1408921 ggcgcctgtg taagcagcca gggaatgttc atgactgtca ttcccggaga aaccccttgt 1408981 ctgtcttgtt tgtttgagca aattcctgtc ggcggggcga cgtgtgatac tgccggcatt 1409041 attccgcctg ctgtgcatat cgtttcagca tatcagcagg ctgaggcatt aaagctgtta 1409101 accggccaaa aagaagcaat acagcggggg tttgtgacat ttgatgtctg gaacaattcg 1409161 catatgaaga ttaacgttaa tcatgtacgc cgtgaggaat gcccatcttg cggagctaat 1409221 gcggtatatc cttatcttca ggattggaac acaccaaaag ctgctgtact atgcggccgt 1409281 gatacagtgc aggtaaggtc agaatcatta aaaagaatcc cgaaacagga gctcattaag 1409341 cggctgaaaa caatcggcaa ggtcgaggct aatgcgtttt tgctgcatat tttttacgag 1409401 gatttcagaa ttgtcatttt caatgacgga cgggcactgg tgcatggaac aaatgatgtg 1409461 aaagaagcca actccgtgtt ggcaagagtg attggactgt aacaacagga ggggtcagaa 1409521 tgctggagaa aagaacaccg ataccggtag acgaggcagt tcggcgtgtc tgccattttc 1409581 aaaaacaagg tgaaacagaa tgggtggcgc ttgaagacag ccttcatcgg tttttagccg 1409641 aagatataac tgcggatcac cacgtacctg cgtttgaccg ttcgccatac gatggttttg 1409701 ctgtcagagc gtgcgatacg gcagaagctt cacgtgaaaa cccagttcgg tttgaagtta 1409761 ttgaccatat tggagcggga gcagtatctg aaaaagaact tggcccgttt caggccgtgc 1409821 ggattatgac tggcgcgcaa atccctgaag gggcagatgc agtcgtcatg attgaactga 1409881 ctcaagcctt tgaggagaat gggaagtcat ttatgtcttt aaaacgccgc tttcagacgg 1409941 gggataatat ttcaaaaaca ggtgaggacg ctcaaaaagg gagtgtttta ctgacaaagg 1410001 gcacccgggt gacaccagga gtgacggctc ttttggcaac attcggatac gcatctgtgc 1410061 ctgtcgtgag aaagcctgta gtcgggatta tcgcaaccgg taccgaattg ctgaatgtca 1410121 gtgatccgct ggaaccggga aaaatccgca acagcaatgc gagtatggta tatgcgcaag 1410181 cgatagaagc aggcgcaaca ccgctttatt tagggaaaat ctctgatgaa ctggataaaa 1410241 gctttgctgc agttaaagaa gcgatgaaaa aggtggactt cctgatcaca actggcggtg 1410301 tgtcagtcgg tgactttgac tttttgcctg cgatctatga aaaactcgga gcggacgtgc 1410361 tgtttaataa agttgccatg cgcccgggca gcgtgacaac ggtggcgcat gcaaacgata 1410421 tgctgctgtt tggcctttca ggtaatccgt cggcatgcta tgtcggtttt gaactgtttg 1410481 tcaaaccgat aatccagaca tggctgctca atgaaacacc gcattcaatt tgtgcggaag 1410541 ctgttttgac caaggatttt ccgaagccga acccatttac ccgatttgtt cgtgcgctcg 1410601 tgcaccatca ggaagggaag ctgttggcga cacccgttgg cttagataag tcgagctctg 1410661 tcacatcact tgcagatgcc aatgcattta ttatcctgcc gggcggtacg cgaggctacg 1410721 aatctggcag aacggttcaa gtgctgctca tcagagaaga gaatggaagt gaatggcctt 1410781 ggtccgtcct ttcccgatcg tccaagttgt aggatttcaa aacagcggga aaacaacgtt 1410841 tattgagcgc attcttgaaa aagcctctga acagggagtc catttgggct gcctgaagca 1410901 ccatggtcac ggcggtgaac cgcaaacgct cacggaagga aaagacacgg accgttacaa 1410961 ggcggcaggt gctgatgtaa cagcggtaga aggtgctggt gtgttacagc tgactgcccg 1411021 ccgcaattgg gatttggcac ggctgattga gttataccaa tttctcgaaa cagactgtct 1411081 tctgattgaa ggctttaaaa aagcccctta tcctaaagtg gttatcctaa gtgaaaagga 1411141 agatctggaa gcgctgcaag cagtaaatat aatcgccatc atctatagaa aaaaagagca 1411201 tatgacagag catcagggat tacccgtttt tcatgcggat gatccggttg ccgtggattt 1411261 tgtgctttca cagctgaagg gggaatctgc ataatggaac ggtttgagat tacgaaaaca 1411321 cccattaata ctgaaaacat catcaaaaaa gtggagaaac gggaagcggg agccattaca 1411381 acatttattg gtacggttcg ggaatggaca aacggaaaaa gaacggttcg gcttgaatat 1411441 gaggcatatg aaccgatggc cgtgcaaatg cttgctcaaa tcggcgctga aatcgaagaa 1411501 aaatgggaag gtgcctcagc tgcgatcacg caccgtatag gtgtgctcga tatcggtgaa 1411561 gcagcggtag tgattgctgt atcttctccc catcgaaaag ccgcatatga agccaatgag 1411621 tatgcgattg aacgcattaa acagattgtg ccgatttgga aaaaagaaat ttgggaagac 1411681 ggtgagcaat ggatcggcga ccagctagaa acgacagctt atccgaacgg aaaaccagac 1411741 ctaagcgagg gagagcagca tgattaaaat tcttttattt gcagggcttg ctgaacaggc 1411801 cggtacacaa gcaatagaaa tagatatgga acaagcaacc acagatgaaa taaaagcgag 1411861 tctaaaagaa caatacggtc ttgaatctat tgatacggct atgattgccg ttaacgaaag 1411921 ctatgtaaaa gaaaatacct ctgtatcttc gggtgacacg gtagccatca taccgccggt 1411981 cagcggggga tgaaaaccgg acggcatttc agccgtccgg tttttctgta tttcattggc 1412041 atatccccaa gtatcctcag catacaatga ttttctgtaa gcgtttattc tacatatgtt 1412101 actccctata aagtaagaga ctcactccat aattagactg aaattttgaa aaataataga 1412161 aatttatttc gggtatcgat atagtgaaga tgataaatgt tggaaaggtg ctggatatgg 1412221 agacatttaa aagattaaaa atgtattatt ggccgtacag aaaagtgttt atgtggtcgc 1412281 ttctagccat gcttttgatg actgcaatta ctgtcgttta tccgattatc ctgcaaatta 1412341 cgattgatga gatcgtactg ggacggcagt atcagcttgc ggcgtgggtc agcttaggat 1412401 ttattgcggt gatggttttg aaaggaatgg ctaccttttt tcatcagtat ttaggtgata 1412461 tgttcgggat caaatccgtt tatcggctga gaaatggtct gtatgaaaaa ctgcagcggc 1412521 tttctttttc ttactatgat aacgcgaaaa caggagattt gatgtccagg ctgactgctg 1412581 atgttgaagg gcttcgtttt ttcttatcat acggtctcgc tgagctcatt cgcttcggcc 1412641 tgctggtagc catcagcctg tcggttatgt tttactattc tgttcctctc acgcttgtga 1412701 caatagctgt tctgccattt ctcgcggttg cggtataccg gtttgacaaa agagtccatc 1412761 ccgccttcag aggcatccgc aaatcgtttg cgaaactcaa tacaaaagtt caggaaaata 1412821 tcagcggcat taatacggtt aaatctcttt ccagggaaga ttttcagatc agcactttca 1412881 ataaagccaa tgcagaatac agggcgcagt atttacaaac atcatccatt tggtctgcgt 1412941 atttcccttt aatggagttc attggtaaca cttgtattgt agctcttctc tcatacggcg 1413001 gttacttggt tatgcaaaat cagctcaatc ccggcgagct tgttgctttc ttcagccttg 1413061 tcaattatat gatgtggccc attatgaact taggttttgt catcaatatg ttctctcaag 1413121 caaaagcgtc aggggaacgc ctgctcgaca ttctggaaaa agaagaagac attacagatc 1413181 atcctcatgc tttgcataaa caaaaattaa ccggagatgt ccatttcaaa aatgtttctc 1413241 ttgcatacgg aaaagaacaa acaaacgcgc tgtgcaatgt aagctttgag gcaaacagcg 1413301 ggaaggtaat cggactgttg ggcccgacag gttcaggcaa aagctcagtg acacagcttc 1413361 tcaccagatt ttacagtcct gttggcggaa tgattaccat tgatcacaaa cccatcacag 1413421 attattcgtt aaaaaccctt cgctccaata tcggggtcgt acttcaagaa tccttcctgt 1413481 tttcatctac gattagatca aatatttcgt atgggcggcc ggatgcctca atggaagacg 1413541 tcatcgaagc ggcaaaaagg gcgcaggctc ataactttat tatggagctt cctgatgggt 1413601 atgacaccat gctgggagag aggggaatgg ggctttccgg cgggcagaaa cagcgtattg 1413661 ccattgcgag agccatctgc ttgaacccga gcattttaat attggatgat gccacaagcg 1413721 cagtagatat gcaaacggag cacagcatac agcttgcctt aaaagaagtc atgaaaaacc 1413781 gcacaacctt tatcgtcgct caccgcattt cttcactgaa acacgctgat gaaattctcg 1413841 tttttaataa aggacgcatt cgtgaaaggg gaacacatca tgagcttctt gaaaaaggcg 1413901 gctactataa aaagatttac gatttgcaat accgtgatgt caaaatgatt aatgagccgc 1413961 atgaggtcgg atagggaggg gccaaatgaa acaagcgaaa aaacaggggg ttttagagcg 1414021 tttctattac tcttcagatg aaatcattga aaagccgttt aactgggctc aaatgtggcg 1414081 gctgctgagc tatgtcaaac catatcgaaa aacaattttg ccgctttctt ttctcactgt 1414141 attgattggc actgctgtga agcttgtgat ccccattttg atcggcgttt atgttcttga 1414201 tcaagcgatt acagggagaa actcggagct gctgattcag ctcattttta ttattagcgg 1414261 tttatatgtc ctcaattacg ccgccaatgt gttaagaatc aggtggatga atcagcttgg 1414321 ccagcatgtc atttacgatt tgcgacagca tttatttacc catgtgcagc gcttatccca 1414381 tcgatttttt gatcagcggt cggcgggatc gatcttagtc aggatcatga atgatattaa 1414441 ctctcttcag gagctcttta caagcggagt catcaatttg ttgaccgact tgctgcttct 1414501 ggccggcgtg attattattt tgtttacgct gagccctgag ctgactatag ccatcatggt 1414561 gacattgccg attatgtttt ttatttcaac aagtctcaga aaaaaaatac gccgatcctg 1414621 gcaaacggta cggctgaagc aatcgaagct caactctcat ctaaacgaaa gcattcaggg 1414681 catccgggtc acgcaggcat ttacgcagga agaagaaaac atggcgtatt ttgacggtgt 1414741 caatcaggag aactacgaat catggcggga agcaactaga aaaaatgcca tgttccgtcc 1414801 gcttgtagaa atgacgaatg cgattgggac ggctgtcttg atttggtatg gagccacact 1414861 catcatgaat gaaaccatta cgattggcgt cttcgtttct tttgctttct atctgggaat 1414921 gttttgggaa cctatttcga gactgggtca ggtctataat cagctgttaa tggggatggc 1414981 atcatcagaa cggatttttg agtttctgga cgaacagcca aatgtcaagg agaagccgaa 1415041 tgccattcat aatgaaaaga taaatgggga gatcagtttt gaagaggttg aattttcgta 1415101 tgatgaaaaa cgaaaagccc ttcacgccgt ttctttctct attcctgcgg gatcgacgct 1415161 tgcgcttgtc gggcatacag ggagcgggaa gacgacgatt gccaatttaa tcagccgttt 1415221 ttatgatgcg gccggaggca ccattaaaat agacggtata ccgattaagg atctttccct 1415281 tgccagtctg cgctctcaaa tcagcattgt cctgcaagat acatttattt tctccgggac 1415341 catcatggaa aatattcgtt ttggaaggcc aaatgcttcg gatgaagagg tgatgaaagc 1415401 gtcccaagcg gtcggagcgg atgagtttat ttccgattta gcggaaggat acgcaacaga 1415461 ggtagaggaa aggggcagcg tactgtctgc cggtcagcgc cagctcattt catttgcaag 1415521 agcattgctc gccgatccgg ctattatcat ccttgacgaa gcaacggcaa gcattgatac 1415581 agagacagaa gtaaaaattc agcaagcgtt aaaaacgctt ctgaaagggc gtacagcagt 1415641 gatgatcgct cacagattgt ctacgatccg cgacgccgac cgcatcattg ttcttgatca 1415701 cggcaggaaa atagaagaag ggaaccatga tcagctgctc gctaaaggag gcatttatgc 1415761 cgggcttgtg aaagcgcaat acagcacagc gatagaataa tatgaaaagc cttcaatatt 1415821 gaaggttttt ggaaatttat tagaaaaaca tgaaactttt tgatatcctt cccgtactat 1415881 ttgttagata ttctcaagga ggttttgaaa tggaaacgaa tgtagaaaaa aacagcggaa 1415941 cggcgactga aaagccttca cttttcggag taatcacaag tccgtccgtt caatttgaaa 1416001 gaataagaga aaggccggct gtatggggac cgcttttgat tgttgcagca attatcatcg 1416061 tcggtgccgt gctgcaatca ctcggtacgg attatagtga gcttttgaaa agccaggata 1416121 cgcaagggct atctgctgaa caaatggaaa ctgtcgcaac aataaccaaa tttggcggaa 1416181 tggcaggcgc tattatcggc ggtatcgcag cattatttat tgcccctctt atttattggc 1416241 tctgtgtaaa agtatcaggc ggtgttacga catataaaaa aatgctttct ctcagtctgt 1416301 ttgtctcttt gattagcagt ctcggattat tggttaatgg aatcgttgct tttacgactg 1416361 acgtgaatcc tctttacagc acgacgtcac tcgcagggat tatcccatct gacggggctc 1416421 tcgccagtgt gttaaatacc tttgaaattt tcagcatctg gagctttgta ttattagcaa 1416481 tcggacttca caaaacggga ggcatctcaa aaaaagccgg gtggatttca gcaatcattc 1416541 tattcggaat tttagttgta ttttcgcttt tttcaggttt aatcaattct gtggcgggtg 1416601 cataagctca tgaaaaaagt ctggatcgga attggaatcg cagttatagt cgctcttttt 1416661 gttggaatca atatataccg gtctgccgct ccgacaagcg gcagcgccgg caaggaggta 1416721 cagacgggga gcgttgaaga aaatgaaatc tcatcaacgg ttatggttcc tggcacgcta 1416781 aaattttcaa atgaacagta tgtcttttat gaagcggata aagggacatt agaagacatt 1416841 aaagtaaagg aaggcgataa agttaaaaag ggcacggctt tagtcaccta tacaaatgag 1416901 cagctgagcc tggaaaaaga acagaaccag ttaacgtctg aatccaaccg gcttcaaatt 1416961 gaccaaattc aagaaaagtt aaaagccttg gacagcaaag aaagagaact ggaaaaacag 1417021 gtaggaaaga aagaagcaga aaaacaaatc gaatctgaac ggacagagct tcaaatgcag 1417081 aaaaaaacag cggagatcga attaaaacaa accgagcttc agcggcagtc acttgccaac 1417141 cgggtgtcag atttagaagt gaaaagcgaa attgaaggca ccgttatttc tgtcaaccaa 1417201 gaagcggcat ccaaaaagtc agatattcaa gagcctgtca tacatatcgg caacccaaaa 1417261 gaccttgtcg tctcagggaa attgtctgaa tacgatacat tgaaagtcaa aaaaggccag 1417321 aaggtcacac tcacttcaga tgtaatacag ggtaaaacat ggaaaggcac ggtttccgca 1417381 gtcgggcttg ttccggatca gcaggagagc gctgcggcac aaggaacaga acaggcggtc 1417441 caatacccgc ttcaagtgaa aataaaagga aatcttccag aaggaaagcc aggctttaaa 1417501 tttatcatga atattgaaac agataaacgg aaagcaaata cgcttccttc aaaggcagtc 1417561 aaaaaagaag atgaccaata ttatgtgtat acagtaaaag acggaaaagc aaagcgagtt 1417621 gatgtcaaaa tcggcgaagt gacagatgac ctgacagaaa ttaaagaggg gcttacccaa 1417681 gatgatcaag tcattttgaa tccatctgat caggtgactg acggaatgga agtgaaatcc 1417741 taaatgattc agctttctaa tgtgcgaaaa agctaccaga tcggaaagga aacgtttgat 1417801 gttctccatt ctattgattt ggacattcat caaggtgaat atgtctcgat tatggggccg 1417861 tcaggatcag gaaaatcgac gatcatgaat attatcggct gtcttgatcg gccgacttcc 1417921 ggtacatatc aattggacgg cgaagacatt tcttcatata aagataaaga actggcggca 1417981 gtccgtaacc ggtccatcgg ttttgtattt cagcaatttc agcttcttcc gcggctgaac 1418041 gcaaaaaaaa atgtcgagct gccgatgatt tattccggga taggcaaaaa ggaacgtcaa 1418101 gagcgggctg agagagcatt ggaaaaggtc gggttagccg atcgaatgct ccacatgccc 1418161 aacgagctgt cgggcgggca gaagcagcgg gtggcgattg cgagggcgat cgtgaatgag 1418221 ccgaaattga ttttagctga tgaaccgacc ggcgcgctgg atacgaaaac aagcgaggcg 1418281 attatggatc agtttacagc attaaatgcc gagggaacga caatcgttct ggttactcac 1418341 gagcctgaag tagcagattg cacgaatcgg atcgtcatgg tgcgtgacgg aaacattgtt 1418401 cctgccagct ccggacaaag gagtgtggga gaatgagcct gttggaaaac atcagaatgg 1418461 ctctaagctc tgtccttgcc cataaaatgc gttcgatctt aacgatgctc ggcattatca 1418521 ttggtgtagg ctctgtcatt gttgtcgttg cggtaggaca gggcggcgag caaatgctga 1418581 agcagtcgat cagcggcccg ggaaatactg tggagctgta ctatatgcct agcgacgagg 1418641 agcttgcaag caacccgaat gccgcagctg aatctacgtt tacagaaaac gatattaaag 1418701 gtttaaaagg aatagaaggc attaaacaag tcgttgcttc gacttctgaa agtatgaaag 1418761 cgcgttatca cgaagaagaa accgatgcta cggttaacgg aataaatgat ggatacatga 1418821 atgtcaattc tttgaaaatc gaaagcggca gaacctttac cgacaatgac tttctcgcgg 1418881 ggaatagagt cggaatcatc tctcaaaaaa tggctaaaga gctgtttgat aaaacctccc 1418941 ctctaggtga agttgtctgg attaacggac agcccgttga aattatcggc gtgctgaaaa 1419001 aagtaacagg cttgctttct ttcgatttaa gtgaaatgta tgtgccattt aatatgatga 1419061 aatcctcttt tggcacaagt gatttcagta acgtatcatt gcaggtcgaa tcagcagacg 1419121 acataaaatc ggctggaaaa gaagcggcac agctggtaaa tgacaatcat ggcacagagg 1419181 attcgtatca agtgatgaac atggaagaga ttgcggccgg aattggcaaa gtaactgcaa 1419241 ttatgacgac gattatcggc tcaattgcag gtatttccct tttggtcggc ggaatcggtg 1419301 tcatgaatat tatgctcgta tcagtcacag aacggacgcg ggaaatcgga atcagaaaat 1419361 cacttggtgc gacgagggga cagattctga ctcagttttt aattgaatca gtcgtattga 1419421 cgctgattgg cggtctggtc gggattggta ttggatacgg aggggccgcg cttgtttcag 1419481 ccattgcggg ctggccgtca ctcatatcct ggcaggttgt atgcgggggc gtgctgttca 1419541 gtatgctcat tggtgttatt ttcggcatgc ttcctgcaaa taaagccgca aagcttgatc 1419601 ccattgaagc gctgcgttat gagtagcctc atgcaacatg catgaggttt ttttatgttt 1419661 agtgatttct actatgaata taaaagactt ttttcattaa aataagaaga aaatgtcgta 1419721 caattgtcct tatttttgtc gaatttacag tttacaaacc ctatagacat acgttaatat 1419781 ggagaaacgt gaaagatttt gatagttatt gaatgaattt gaatgatttt agttgcctaa 1419841 accgaaaata gcgtttacaa tgaaattgta ttcaaaatga atacgttttc attaggaggt 1419901 gaagcatgct aactcctgaa cggcatcaat tgattattga tcaaatagaa aagcatgatg 1419961 tggtaaagat tcaagagctt ataaatctga ctaatgcttc tgaatcaaca atcagaagag 1420021 atttatcgac ccttgaagaa cgcggttttt taaagcgcgt tcatggtgga gcggccaagc 1420081 tttccgatat cagacttgaa cccgatatgc ttgaaaaatc atccaaaaac cttcacgata 1420141 aactgaagat tgctgaaaaa gctgcttctc ttttagaaga aggggattgc atttaccttg 1420201 atgcaggcac gacgacattg cacatgattg attttatgga taaaaccaaa gatattgtcg 1420261 ttgtcacaaa cggggtaatg catatcgatg cattaataag gaaagaaatt tctttttatc 1420321 tgcttggagg atacgtaaag cacagaacgg gcgcgattat tggaggcgct tcattggttg 1420381 ccatggacca gtacagattt gacaagagtt ttctggggac aaacggtgtc catacagagg 1420441 ctggatttac aacgccggac cctgatgagg cccttttaaa acagaaagcg atcaaacagg 1420501 caaaacacgc ttacgtctta gcagaccctt cgaagttcgg agaaatttca ttttcggcat 1420561 tcgccggaat aggcgacgca acaatcatta cgactgacgc tgaagagctt acattcgata 1420621 attaccaaga aaaaactgtc gtaaaggtag tgaaaccatg atttacactg taacacttaa 1420681 tccatctgtc gattatatag ttcacgttga agattttact gtaggaggcc tgaaccgttc 1420741 ttcgtatgat accaagtatc cagggggcaa aggcatcaac gtatcgagac tgctgaaaag 1420801 acaccatgtg gcgtctaaag cgctcggatt cgtcggcgga tttaccggag aatatatcaa 1420861 aacattttta cgggaagaaa acctggaaac agctttttct gaagtaaaag gggatacccg 1420921 tatcaatgta aagctgaaaa cgggtgatga aactgaaatt aacgggcagg gaccgacaat 1420981 ttcggatgaa gatttcaaag cctttttaga acagttccaa tctttgcaag agggagatat 1421041 cgttgttctt gcaggaagca ttccatcttc actccctcac gatacttatg aaaaaatcgc 1421101 agaggcctgc aaacagcaga acgcacgagt tgttctggat atctcaggcg aggctctttt 1421161 gaaagcaaca gaaatgaaac catttttgat gaagccaaat catcatgagc ttggagaaat 1421221 gttcggcacg gccattacat ctgttgagga agccgttcct tatgggaaaa agcttgtaga 1421281 acaaggcgct gaacatgtaa tcgtatcaat ggccggagac ggagcgcttc tgtttacgaa 1421341 cgaagctgtt tattttgcta acgtgccaaa ggggaaattg gtaaactcag tcggagcagg 1421401 ggattccgtt gttgcaggtt tccttgccgg aatttccaaa cagctgccgc ttgaagaagc 1421461 attccgctta ggagttactt caggcagtgc taccgcgttc tctgaagaac ttggaacaga 1421521 agaatttgtc cagcagcttc ttcctgaagt taaggtcaca cgtctataga ggaggaaaca 1421581 caagtgaaaa taactgagct tttaacgaag catacgataa agcttaatat tgagagcaaa 1421641 gaaaaagaaa atgttattga cgaaatggtc actgttcttg ataaggctgg aaagttaaat 1421701 gaccgacaag cctataaaga agccatttta aatcgcgaaa gccaaagctc cacgggtatc 1421761 ggtgaaggaa tcgctatccc ccatgcgaaa acggcaagcg ttatcaaccc ggcgatcgcg 1421821 ttcggacgtt caaaagacgg cgtcgattat gaatcattag acggccagcc ggctcactta 1421881 gtgttcatga tcgcggcgac tgaaggcgca aacaacactc accttgaagc attgtcaaga 1421941 ctttcaacgc tgttaatgcg tgaagaaatc cgtaagcagc tccttgaagc tgagtctgaa 1422001 gatgccatca tcgacattat taatcagcac gataaagatg atgacgaaga ggaagaggaa 1422061 gaagaagcgg caccagcacc tgccggaaaa gggaaaattt tagcggttac tgcatgcccg 1422121 acaggtattg cccatacatt catggctgcg gatgccctta aagaaaaagc gaaagagctt 1422181 ggtgtggaaa ttaaggtcga aacaaatggg tcaagcggca ttaagcacaa gctcactgcc 1422241 caagaaatcg aagatgcacc tgcaatcatt gtcgcagcgg acaagcaggt tgaaatggaa 1422301 cgttttaaag gcaagcgcgt acttcaagtt cctgtaacgg cgggtatcag acgtccgcaa 1422361 gagcttatcg aaaaagcgat gaatcaagat gcgccgattt atcaaggcag cggcggcggt 1422421 tcagcagctt caaatgatga tgaagaagcg aaaggcaagt ctggaagcgg tatcggaaac 1422481 acgttttata agcacctgat gagcggtgtc agcaacatgc ttccgttcgt agtcggcggc 1422541 ggtattctcg ttgcgatttc attcttctgg ggaattcact ctgctgatcc gaatgatcct 1422601 agctacaaca cgtttgcagc agcattaaac tttatcggcg gcgacaatgc attaaaactc 1422661 attgttgcag ttctggccgg tttcattgcg atgagtattg cagatcgtcc tggttttgcg 1422721 cctggtatgg tcggcggatt tatggcaact caagcgaatg ctggattctt aggcggctta 1422781 attgccggat tccttgccgg ttatgtcgtg attttactga aaaaagtatt tacgtttatc 1422841 cctcagtcac ttgatggatt aaaacctgtt ttgatttacc cgctgttcgg tatttttatc 1422901 actggcgtat taatgcaatt tgtcgtcaat acacctgtag cggcatttat gaatttctta 1422961 acaaactggc ttgaaagcct tggtactgga aaccttgtgt taatgggtat tatcttgggc 1423021 ggcatgatgg cgatcgatat gggcggtccg cttaataaag cagcctttac gttcggtatc 1423081 gccatgatcg atgcaggcaa ctatgcgcct catgcagcaa tcatggccgg cggtatggtt 1423141 cctccgcttg gtatcgcact tgcaacaacc attttcagaa acaaattcac tcagcgtgac 1423201 cgtgaagctg gtattacatg ctatttcatg ggagctgctt tcgtaacaga gggagcgatc 1423261 ccatttgctg cggctgatcc gcttcgcgtc ataccagctg ctgtagtcgg tgcagctgtt 1423321 gccggcggat taactgaatt cttccgagta acgcttccgg cgcctcatgg aggagtattc 1423381 gtagctttca ttacaaacca tccgatgctt taccttttaa gtatcgtgat cggtgctgtc 1423441 gtgatggcaa ttatcctcgg tatcgtcaaa aaacctgtta cagaaaaata agaaaaaaag 1423501 cgtccttggt tcgaaaggac gctttttctt atccggccgg cagggagcgc ggttaagtta 1423561 tgtattttat tcttttttat gataaagtaa aagaagagaa acaactgaca tagcaattgt 1423621 ctaggaggaa acactttgac cgaggaaaaa aatacgaata ctgagaaaac ggcgaagaaa 1423681 aaaaccaata cgtacctgga atggggtaaa gcgattgtca tcgctgttct gctggctctc 1423741 ctgatccgtc actttttgtt tgaaccgtat ttagttgaag gttcatctat gtatcccaca 1423801 ttacatgacg gagaaaggct gtttgtgaat aaaacagtca actatatcgg cgagctgaag 1423861 cgcggagata tcgttattat caacggtgaa acttctaaaa tccattatgt aaaaagattg 1423921 atcggaaagc ctggagaaac cgttcaaatg aaggatgaca cgctttatat aaacggtaaa 1423981 aaagtagccg agccttactt gtctaaaaac aagaaggaag cagaaaaact tggtgtcagt 1424041 ctgacaggag actttggacc ggttaaggtt ccgaaaggca aatactttgt catgggagat 1424101 aaccggctga attctatgga cagccgaaac gggctgggac tgatcgcgga agatcgaatt 1424161 gtcggcacat cgaagtttgt ctttttcccg tttaacgaaa tgcgtcaaac aaaataaaaa 1424221 cgccttgctg gcctaggaca gcaggcgttt ttattttgaa aaagaagcga ccaatgcaat 1424281 gcataaaacc gtgatgaaca ctgaaccgat aatagccagc acactgaaga aaaggtgaac 1424341 ctgtttgttc tcttttccgc gcttttctaa tagccgttta gaaaaaatgt gcgaaaatat 1424401 gtaaataagg gctatgccta tatataagcc gatatctttg gcggtaaagc ctgttacggc 1424461 aaggtaaaag cccgtaaaaa agatcagtaa gcaatattca gtaagtgtta aaagcctcaa 1424521 cgtgttcctc catgagagtg tgtaattttc caggcggatg cattctctct ctttaattgt 1424581 aacacagctg gctggtttgg gtgtataagt gttttctctc tgttttatca gggaatcatt 1424641 tctcttgccc tgcattcatg gtatactttt attgatgata gacatgatgg aggataataa 1424701 atgattgctg taaataatgt aagcttgcgg tttgcggatc gcaagttatt tgaagatgtt 1424761 aatattaaat ttaccccagg caactgctat gggttaattg gtgcaaacgg tgccggtaaa 1424821 tcaacgtttc taaaggtgct gtcaggcgaa atcgagcctc agacaggcga cgtgcatatg 1424881 agtcctggcg agcgtcttgc cgtcttgaag cagaaccatt ttgagtacga agagtatgaa 1424941 gtgctgaaag tggtcattat gggccacaaa cgcctgtatg aagtcatgca ggagaaagac 1425001 gctatttaca tgaagcctga tttctcagat gaggatggga ttcgtgctgc tgagctagaa 1425061 ggtgaattcg cggaactgaa cggttgggaa gcggaaagtg aagctgcgat cctgttaaaa 1425121 ggccttggta tctcagaaga tctgcacaca aaaaagatgg cagacctcgg cggttcggag 1425181 aaggtaaaag ttctcttggc acaggcatta ttcggcaagc cggatgttct gctgctcgat 1425241 gagccgacga accacctgga ccttcaggca attcagtggc ttgaagagtt tctgattaac 1425301 tttgaaaaca cagttattgt cgtatcccat gaccgtcact ttttaaataa agtatgtacg 1425361 cacattgccg accttgattt taacaaaatt caaatctatg tcggaaacta tgatttctgg 1425421 tacgagtcaa gccagctggc gttaaagctt tctcaagaag cgaacaagaa aaaagaagag 1425481 cagattaaac agcttcaaga gtttgtcgct agattcagcg ccaatgcgtc taaatctaag 1425541 caggctacat caagaaagaa acttctcgaa aaaatcacgc tggatgatat taaaccgtct 1425601 tcccgccgct atccttatgt taacttcacg ccggaacggg aaatcggaaa tgatgttctt 1425661 cgcgtggaag gcttaacaaa aacaatcgat ggcgtaaagg tgcttgacaa tgtcagcttt 1425721 attatgaatc gagaagataa aattgctttc actggccgaa atgaacttgc tgttactacg 1425781 ctgtttaaaa tcatttccgg ggaaatggaa gctgacagcg gaacgtttaa atggggtgtt 1425841 accacatctc aagcgtattt tccaaaagac aacagcgaat atttcgaagg cagtgatctg 1425901 aaccttgtag actggcttcg ccaatattct ccgcacgacc aaagtgagag ctttttacgc 1425961 ggtttcttag gacgcatgct gttctctgga gaagaagtcc acaaaaaagc aaatgtactt 1426021 tccgggggag aaaaggtccg ctgtatgctg tcgaaagcga tgctttctgg cgccaatatt 1426081 ttaattttgg atgagccgac caaccattta gacctagagt ccattacagc gctcaataac 1426141 ggcttaatca gctttaaagg cgctatgctg tttacttccc atgaccatca gtttgtgcag 1426201 accattgcca acagaattat agaaattaca cctaacggca tcgtcgataa gcaaatgagc 1426261 tatgacgagt tccttgaaaa tgctgatgtg cagaaaaaat tgactgaact atacgccgaa 1426321 taaaaaagca gagatttctc tgcttttttt gatacctaaa tgtgaaagga gatcacaaca 1426381 tgaaattttt ggttgtcgga gcaggtggag taggcgggta tattggcgga cggctttcgg 1426441 agaaaggaaa tgatgtgaca tttctcgtgc gccaaaaacg agctgagcag cttaaaaaaa 1426501 ccgggcttgt catccatagt gaaaaaggga atgtatcatt tcagcccgaa ctaatcagtg 1426561 ccggagaaac agggcaattt gatgtcgtta tcattgcttc taaagcatac tcgcttggtc 1426621 aagtgataga ggatgtcaaa ccatttatcc atcaagaatc tgtcattatc ccttttttaa 1426681 atgggtaccg ccactatgag cagctatttg cggcattttc aaaagaacag gtgctgggcg 1426741 gcctgtgttt tatagaaagt gctttagaca acaaaggaga aattcatcat acgagcgcat 1426801 cgcatcgttt tgtatttgga gaatggaacg gcgagcgtac ggagcggata agagcgcttg 1426861 aagaggcatt ttcaggtgtg aaggctgaag tcatcattag cgggcatatc gagaaggaca 1426921 tttggaaaaa gtatctcttt attgcagcgc aagcggggat cacaacgtta tttcaacgac 1426981 cgcttggccc aatcctcgcc acagaagccg gacgtcacac ggcccaaact cttattgggg 1427041 aaatttgcac tgttttacga aaagaaggtg ttccggctga tccggctctt gaggaagaga 1427101 gctttcgtac gatgaccagc atgtcttacc atatgaagtc ctccatgctt cgggatatgg 1427161 aaaacggcca aacgacagaa ggcgaccacc tgcatggatt tttgattgaa aaagcaaaac 1427221 gtttatctct cgctgcacca gtattagaaa ccgtttatgc gaatctgcaa atgtatgaag 1427281 cagaaaaata aaaaaaggag gcggaaaagc ctccttttat ttacttaaaa agcccaattt 1427341 ccgtttctga agataggctc tcttttcccg tctgccgtaa ttccgtcaat attcatatcc 1427401 ttagaaccga tcataaagtc cacgtgtgta atgctttcat ttaggccttc tttgacaagc 1427461 tcttcacgag acatctgctt tccgccttca atattaaagg cataggcgct tccgatcgcc 1427521 aaatgatttg acgcgttttc atcaaacagc gtgttataga aaagaatgtt tgattgtgat 1427581 ataggcgaat cgtaaggaac aagtgccact tcacctaaat agtgagaacc ttcatctgtt 1427641 tccaccagtt cttttaaaat atcctcacct ttttcagctt taatgtcgac tatacggcca 1427701 ttttcaaacg tcagggtgaa attttcaata atatttccgc cgtagcttaa tggttttgtg 1427761 cttgatacca ctccgtcaac cccgtctttt tgcggcagcg tgaacacttc ttctgtcggc 1427821 atattggcca taaactcatg gccactttca ttcacgcttc ccgcacctgc ccaaacatgc 1427881 ttcctaggca gcttaattgt tagatcagtt ccttctgctt gataatgtaa ggcagcgtaa 1427941 tgtctctcgt tcaaatggtc aactttttca tgaagatttt ggtcatgatt gatccacgcc 1428001 tgaaccgggt tgtcttcatt tacgcgcgtc gctttaaaaa tttcttccca cagaaggtgg 1428061 atcgcttcct cctctgattt gccaggaaac accttgtgag cccagcctgc tgatgccgca 1428121 cctacgacag tccagctgac tttgtctgat tgaatatatt gtctgtatgt atgtaatgct 1428181 ttgcctgctg ctttttggaa tgccgcaatc cgtttggaat ctataccttt tagcaagtct 1428241 gggttcgacg acacaacaga aatgaaagca gctccatttt tggcaagctc ttctctgcct 1428301 tttgcttccc attcaggata ttcttcaaat gcttcaaacg gcgcaagttc gtattttaat 1428361 ttggcgactt cgtcatcctg ccaattcacg gtgacgtttt ttgcgccctt ttcatatgcg 1428421 tgttttacaa ttaaacggac aaaatcccga acgtctgttg aagcatttac gactacatac 1428481 tggccttttt ggacattaac gccgacttct accgccagct gtgcatatgt atttaatttc 1428541 tgtgaaaatg aatccatgaa tcattcctcc aagctttttt ctcatcatat caaatatgat 1428601 cctataaagg aaagaaggag cccaaagtga aaaacccaaa acgacacgtc ttgggttttt 1428661 tcaatattat ggatgattca gttttacagt gccgcctgca ggcgaatggg gcatatttgc 1428721 caaagaaatg ctcatgcctc caagaataat tccgcttaaa atggctgcga tcgctactct 1428781 tcttcctaaa tctcttagca tctgtttcct ccttaacgtt tctccatttc ccacaatatg 1428841 aaggaagtga ggaaaaaaga agcaagaaat ttgccgcgtg tgagaatttt gcgggtaaag 1428901 actatttaat tgccttttgc agcttatcaa tcacttctaa agaacggcct gtgccgattg 1428961 ctacagattc aagcgggttt tgcgccacgt gtacaggcac gacaatctct tctgtgagcc 1429021 attctttaat tccattaagg agcgcgccgc cgcctgttaa aataacgccg cgatcaacaa 1429081 tatctccgct caattcaggc ggacagtcct caagtgtcgc tctgatggct tcaagaatat 1429141 gcaggaggga ttcacgcatt gcatcttgaa tttcgttgga ttgaagcata atggtttttg 1429201 gaagacctgt cacgaggtca cgtccccgaa tttccattgc ctctggtata tgttcaatca 1429261 gagcatggcc aatttccatt tttacctgct cagctgtgcg ttcgccgatc agcaaattgt 1429321 attttttacg gacgaaagaa acgatatcct catcaagctg gtctccgccg atcctgatag 1429381 aatggcagga aacaacgcca ccgaaggaaa taatagcgac ctctgtcgtc cctccgccga 1429441 tatctactac cacattggca accggctcat caaccggtaa atccgctccg atggcggctg 1429501 caactggctc ttcgattaaa tgaacgtttt tcgcgccgca atttttcacc gcatcactga 1429561 tggcgcggcg ttctactgct gttgagcctg atggtgtgca aacgactacg ttcggttttc 1429621 tgaacgacat gccgatgctt tttgcggctt ttttcataat gtgctttagc aggtcagttg 1429681 tcatatcata gtctgcgatc acgccatctt tcatcggtct gacagcgaca atttttcccg 1429741 gtgttttacc gatcatgttt ttcgcgtcag ctccgattgc aagcactgct tttgtcgtcg 1429801 tatccactgc gacaacagat ggttcattta ggataatccc tttatttttg ctgtaaacaa 1429861 gtatattagc tgttcctaag tcaatcccga tttcagttga ttgaaacatg ttttcaccca 1429921 atctctatcc taatttaata tgattctaca tttaaagttt ctcagaaata ctgcgatttt 1429981 tgggggtgtg cgtcggtaaa gaaatgtttt tgtaaaaaat caaggaactg tgtaacagaa 1430041 gtaatacatt tttcggtttt atggaaaaaa tatcttgtaa ttcttataga aagcgggaaa 1430101 ctttttcaaa gtttcattcg tctacgatat attgaggtac atccttaaaa cattacatga 1430161 gaaaagaaac atttaaagga agaagggttt ttatgaaatc aataggtgtt gtgagaaaag 1430221 tagatgaatt aggccgcatt gtcatgccga ttgagttgag acgggcattg gatattgcca 1430281 taaaagacag cattgagttt tttgttgacg gagataaaat tatcttgaaa aagtacaaac 1430341 ctcatggcgt ttgtttaatg actggagaaa tcacttcaga aaataaagaa tacggcaacg 1430401 gtaaaattac gctaagccct gagggtgcac agctgcttct cgaagaaatt caagccgctt 1430461 taaaagaata aaattatgct aaaaaaggcg gagtgatatc atctccgcct tttttgcgtg 1430521 ccaatttttg attaccgccg cctaagataa gacatcaaga tatttggtaa tgaatgattt 1430581 gggatacttt acatatttta ctcaattatt tgtcgaagaa tggtacaata agtagagaaa 1430641 cacaagcggc aggtggtcat atgagaaaat atcaagctcg tatcatttcc atcattttgg 1430701 caatgatttt tataatgttt tgggattatt tattttattt tataggcaaa aacccgatta 1430761 attggcctgt tgatattgtg tatactgcag tcacgctggt aagtgtctgg atgttggctt 1430821 attatattga tgagaaacag cagctggtta agaaaatgaa ggataacgaa tggaagtata 1430881 aacagctttc tgaagaaaaa aaccgcatca tggataattt gcaggaaatc gtatttcaaa 1430941 cgaatgcaaa aggtgaaatt acatatttaa accaagcgtg ggcatctata accgggtttt 1431001 caatcagtga atgtatggga acaatgtata acgattactt cataaaagaa aagcacgtag 1431061 ccgaccacat taacacccaa atccaaaaca aagcgtcttc tggcatgttt acggcaaaat 1431121 acgtgacaaa aaacggcacg attttttggg gagaagttca ttataaactt tactatgacc 1431181 gggatgacca atttacaggc agcctgggta caatgtcaga tatcactgag cggaaagagg 1431241 ctgaagatga gctcattgag attaatgaac ggctggcgag ggaatcccag aaactatcaa 1431301 tcacaagtga acttgccgca ggtattgctc atgaggtcag aaacccttta acatctgtca 1431361 gcggtttcct ccagattatg aaaacacaat atccggacag aaaagactat tttgacatca 1431421 tcttttcaga gattaaaaga atcgatttag tgctcagcga gctgctgctg cttgcaaaac 1431481 cgcaggcaat cacatttaaa acacaccagc ttaatgagat cttgaaacaa gtcacgacat 1431541 tgcttgatac caatgcaatt ctgtccaata tcgtcataga gaaaaatttc aaagagacag 1431601 atggctgtat gattaatgga gacgaaaatc agctgaagca ggtctttatc aacatcatta 1431661 aaaacggaat tgaggcaatg ccaaagggcg gtgtcgtaac catttcaact gctaaaaccg 1431721 cctctcatgc agtgataagc gtaaaggatg aaggaaacgg catgccgcag gaaaagctga 1431781 agcagattgg caaacctttt tattcaacaa aagaaaaggg cactggactg ggacttccca 1431841 tttgtttgag aatcctgaag gaacatgacg gggaattgaa aatcgaaagt gaagctggaa 1431901 aaggcagcgt ctttcaagtg gttttgcctt taaaatcaga cagctgagag gagaaaaata 1431961 aagtgaactc gcttctgttt gtatacggga cattaagaaa gcatgaaaaa aaccatcatt 1432021 tgctggcaca atcggcatgt atcaatgagc aggcgagaac aaagggaagt ttgtttgctg 1432081 caaaagaggg gcccacagtt gttttcaatg atgaagatga aggctatata tatggcgaag 1432141 tatatgaagc agatgaattg tgtatacata agctcgatca attttttcaa ggatatcata 1432201 aacaaacggt gtttgtagaa acggatgtcg ggattaaaat tgcgcttatt tattttatga 1432261 acaaagacgg gtgtgccggt tttacgaaaa taagcagcgg cgactggaaa gaacatcaga 1432321 tgatcagcaa atcgaaaaat cccatttatt attttgccta tggatcatgc atggataatg 1432381 cccgctttca aaaagcggga gtcgatcact attttcaaga tccagtagga agagctgttt 1432441 taaaaggata cacaacccgc ttcacgctaa aaagggaaga cggttcaaga gcggacatgt 1432501 tggaagacgg aggaacaaca gaaggcgttt tataccgtat cccttattct gctctctcct 1432561 atctatataa aagggagggc gtcgaatctc ttacgtatcg gccggcattt gtagacgttg 1432621 aagctggcgg aaggcactac aaagactgtt taacctttct cgtcctccaa aaagaagcgg 1432681 aaattgcccc gcctcagcac tatcagattg aaatcgaacg cggagcggag ctgtatttgt 1432741 cgcctgagtt tactgaaaag ctcaagcggc atatgaattc gctgccaaaa ggataacact 1432801 gtaacaaaag aatatgataa aatttgatca atatcatgtc atataaagga gcaccacgat 1432861 gaaaaaagaa tttgcggtaa ttgggctggg ccgttttggt ggcagtattt gcaaagcatt 1432921 aagcgaagaa ggcgtcgagg ttatggcaat ggatatcgat gaagataaag tcaacgagta 1432981 tgccaagatt gcatctcacg cagttatcgg tgattcgaca gacgaatctg tcctgaaaaa 1433041 tttaggcctg cgaaattttg accacgttat tgtagcaatc ggggaaaata ttcaagcgag 1433101 tattttaacg acactcattc tgaaagaact tggcgtccat acgattacag ttaaagcgca 1433161 gaacgattat cacgaaaaag tgctgtctaa aattggtgcg gatcacatcg tccacccgga 1433221 acgcgatatg gcaaaacgaa ttgcgcataa tatcgtgtcc aacaatgtac ttgactattt 1433281 ggagctgtct gaagagcata gtcttgttga aatcgtagct aacagccgcc tggctggaaa 1433341 tacgcttctc gatttagata ttcgcgcaaa atacggtatt aacatcgtag ccataaaaag 1433401 gggcaaggaa gtcatcgtat caccgcttgc aaccgaagtc atccaccaag aagatatact 1433461 cattgttatt ggatcagtta cagacatctc ccgtttcgaa aaaagagttc ttcatacaaa 1433521 atagcagcca aataagccgt cctcaaaggg cggtttttca tattatcaga atataacaac 1433581 tttaatgaac tgagcgtcaa tttcttaaaa tttcattgac taagcacagg cgttccgata 1433641 gcatattgta ccatataata aaaaaaggag gggcctattt gaataaagaa gcgctagtca 1433701 ataggctgaa tgcttcagcc aaaagacaaa aagctgatat cgtcattaaa aacggaaaaa 1433761 tcatggacgt atataatcaa gaatggatat atgaagatat tgcgattaca gatggagtta 1433821 ttgtaggcct cggtgagtat gaaggcgaaa atatcattga tgcagaggga caaatgattg 1433881 ttccgggttt tattgatgga catgtacata ttgagtcgtc aatggttaca ccgattgagt 1433941 tcgctaaagc agtgttgcct catggcgtga cgacggttgt tacagatccg catgagatcg 1434001 cgaatgtgtc tggtgaaaaa gggattgagt ttatgcttga acaagctcgg catacaccgc 1434061 tgaatatcca ttttatgctt ccttccagtg tgcctgccgc aagttttgag cgatcaggcg 1434121 caattctcaa agctgccgat ctcaagcctt tttatgaaga agaagaagta ttagggctgg 1434181 ctgaagttat ggattatgtg tcggttcagc aggctgaaaa agacatggtt cagaaactgc 1434241 ttgatgcccg tgtggcagga aaaaggatag acggtcattt agctggttta tcaacagacc 1434301 tcattaacat ttacagaacc gcatttgtct taaacgacca tgaagtaaca tcgaaggaag 1434361 aagcccttga tcgtatcaga aggggcatgt atgtcatgat gcgtgaagga tcagtcgcca 1434421 aaaacacgct caatgtgctg ccggcggtga atgaaaagaa cgcacgccgg ttctttttct 1434481 gtacggatga taagcatgtg gatgatttat tgtcagaggg aagtgtaaac catcaggtga 1434541 aaatggcgat tcaagccgga cttaatccgt ttttagccta tcagctagga agcctcaatg 1434601 cagccgaatg ctacggatta gatacaaagg gagcgattgc cccgggtttt gacgctgatt 1434661 tgctttttgt atctgatctg gaaaatgtca ctgtcacaat gacgatggta aaagggcaga 1434721 ctgttgctga agacagcaaa gcggtctatc aggatcatgc ttcaactgca gcaccagatc 1434781 aggcactgct tgattctgtt aagcttgctg ctcctcttaa caaacaggat tttcatatgc 1434841 caatcgattc agagcagcag atcaatgtca ttcaaatcat accaaatcag cttgaaacac 1434901 gattagtaca agttccggct cctgttgccc gcgaatttga gcctgacact gagcttgatt 1434961 tgttaaagat tgcagttgtc gagcggcata aaggattaaa agaaaccgga cttggtgttg 1435021 tgaaaggttt tggattcaag agcggagcga ttgccacaac catttcacac gactcccata 1435081 atattattgc cgtcggaacg aatgatgagg atatcgcggc ggcagttaat aagctgcagg 1435141 aaattggcgg aggattaaca attataaaaa atggggaaga gctccattca gtaccgctgc 1435201 cgattgcagg gttattatcc gaccaatctg cagagcaagt gaatcaaagc ttgctgacgc 1435261 ttcatgataa attgtcgtta atcggtttca caggcggatt taatccattt ttgacattgt 1435321 cgtttttagc gttgcctgtc attcctgata ttaaaatgac gactacggga ttattcgatg 1435381 taaaatcatt tcaacacata tcactgcaat aaaaagaggc actcccttag ggagtgcctc 1435441 tttttttaaa cctccataat gatcggcagg atcattggac ggcgctttgt tttttcgtac 1435501 aagaaaggtg caagcgtgtc tgtaatttcg tttttgattt cagaccattg agtcgttttt 1435561 cgttccatta ctttttgtaa gtgatttgaa atgagctctt gagcgtcgtt gatcaagtca 1435621 ccagattctc tcatgtacac aaatcctctg gaaatcaaat caggacccgc tgaaatcttg 1435681 aagtcgtcca tgtcaatgct gacaacaacg atgacaagtc cttcttcaga gagaattctg 1435741 cgatcacgaa gtacgatatt gccaatatca ccgataccgc ttccgtcaat gtacactgaa 1435801 ccggacggga tttttcctgc aactgaagcc tcatcgcctt taagtgctaa tacttcacca 1435861 ttatccatga taaagcagtt ttcctctggg atgccacaat ctgttgcaag tttgacatgc 1435921 atcttttgca ttctgtactc accgtgaatc ggcatgaaga atttaggctt gattaaacga 1435981 agcatcagct tctgttcttc ctgtccgccg tgaccggatg tatggatatc gttaagaggg 1436041 ccgtgaataa cctcagcacc cgcacgatac agctggttga ttgttcgact cacgctgatt 1436101 gtgttgcctg ggatagggga tgaagaaaat acgactgtat ccccaggatt gattgaaatt 1436161 tggcggtgtg tgccgtttgc aattcttgat aacgccgcca ttggttcccc ttggcttcct 1436221 gtacataaaa ttgttacttt attagcaggc atacgattga tttcgttatg ctcaataaac 1436281 gtatttttag gacagttaat ataaccgagt gtctgtccaa tttcgatagc cgattccata 1436341 ctgcgtccaa atacggcaac ttttcttcca ttttgtacag cagcttcaat tacctgctgc 1436401 aagcggtgaa tattcgacgc aaatgtggcg aagataattc ggccgtccac cttgcggaaa 1436461 atgtcatgaa tgctttctcc tacacggcgc tcagacatgg taaactccgg attttcactg 1436521 tttgtgctgt ctgaaagaag gcacaaaacg ccttctttac cgatttcggc cattttcgtt 1436581 aagtttgccg gctcgccgac tggagtaaag tcgaatttga aatccccagt atgtacgatg 1436641 tttccgggcg gcgtttttac aacaatgccg taggaatccg gaatactgtg tgttgttctg 1436701 aagaatgaca cagccgtttt gcggaacttt acaatatcat cctcgccgat aatgttcagt 1436761 ttcgtctgtc tcaataatcc atgctcttca agtttattcc gaagtaagcc gatcgcgagt 1436821 tttccgccgt atacaggaat attcacttgt ctgagcaggt atggaatacc gccgatgtgg 1436881 tcttcgtgcc cgtgggtgat aaaaagccct ttaattttat cttcgttttt gactaaatac 1436941 gtataatcag ggatgacgta gtcaattccg agcagttcgt cctcgggaaa cttgatcccc 1437001 gcatcaatca gtacaatttc atcctggaat tgcaccgcgt acgtattttt accgatttcg 1437061 cccaaacctc cgagggcgaa aacagcagtc tgatcatttt ttacaaattt cataccgctc 1437121 ataactccaa tactttaaaa ttttcgctct gttgttcata ttctaagaat gcaccatcaa 1437181 caggtgtaat aaactcaata ttaaatttct tttctttcag ctttgttctg acgtcacgct 1437241 cagatacgcc ttcaatataa agtgaatctg tcttttcccg aacaggtact tcgtcagcct 1437301 tctcttgata aaatacctta taaatcattc caaatctctc cttaaatgcc gtatgttaga 1437361 ctcgctcatt ctattatatt cgaaaacgga atataaggaa agccttgagc aaaataagga 1437421 tctctcaaaa agtgaaagat cccttgtcag gcaattgctt tcttacggag cattccgttc 1437481 cattgtcttc tgagtttctt tcttaattta cgcagcatta gccagtccct cctttaatga 1437541 aaaatttgtc ccagagttct tttatacaaa tagtatacgg agattgagga agacttttcg 1437601 tggttattaa tggaatttaa tatgattttt gaacgaaatt gtttgctgaa tgacaatctt 1437661 tttgtatgat gagggtggga attgcagacc aagacgataa aggggaagtt gcgatggatt 1437721 ctaaattaat cttttttgat attgacggca caatatatga tcatgataag aatataccgg 1437781 aaagtacgag aaaaaccgtg gcggagcttc agcgccaagg gcatcatgtg tttattgcca 1437841 gcggccggtc tccatttttg gttaagccga ttttggagga gctgggcatc cactcattta 1437901 tttcctacaa tggacagttt gttgtctttg aaaatcaagt gatttataaa aatccgctgc 1437961 ctgaaaatgc aatcaggcga ttattaaagc aggcggatga aggcaagcat cctgttgtgt 1438021 ttatggctga ggacacgatg aaagcgactg ttgcggatca cccccatgtt ctcgagggaa 1438081 tcggcagcct taaaacagat tatccagaga ccgatgacct tttttatgaa ggaaaagaaa 1438141 tttttcagct tcttttattt tgtcaggatg aagaagaaaa agcttatgcc gcttttcctg 1438201 agtttgatct agttcgctgg catgagctat cgactgatgt tctgccgcac ggaggttcga 1438261 aggcagaagg aatcaaaaaa gtgattgagc gtcttccgtt tgatatcggc gatacatatg 1438321 ctttcggcga cggattaaat gatttgcaaa tgattgaata cgttgggaca ggcgttgcta 1438381 tgggaaatgc tgttcccgaa ctgaaagaaa tcgcggactt tgtaacaaaa ccggtggacg 1438441 aggatggaat tgcatacgct gtcaaagaat tgggcctttt aaaataaaga aacggctggc 1438501 attgtgccag ccgttttctc ttttagcgct caattgcgat tgcattttca ggttctttga 1438561 aaggattttc cttatcaata tgatcataga acataacgcc gttcaaatga tcgatctcat 1438621 gctgaaacac aatagccgga aatcctttta aacgaatatc aatattttcg ccttctagtg 1438681 ttgttccttt tactctgatg cgagcatagc ggggaacata accgggaatc gcttcatcca 1438741 cagagaggca gccctcgccg cttgttaagt agcttttttc aactgaatgg ctgacgatct 1438801 taggattaaa cagagcatag ctgtataatt taccggaagc atcttccgca tgaacggcga 1438861 tcattcgttt tttgatatta atttgaggag ctgcgagtcc tacgccaggg cgcagcttgt 1438921 atttttcggc taattctgga ttttggctgt ttttaacaaa ttcgatcatg tcggccagct 1438981 gctgtttttc tgcatcagtt ggaggcagct caacaggttc ggcagtctct ctgagggctg 1439041 gatggccgtc acgtacgatg ttttccatag taatcaagaa acttcactcc taaagcttaa 1439101 tatgtaaatt atatcggatt tcttcacaaa ggtgcaacga aacgaatgac cagccgtata 1439161 tggctggtca atttcatgct gtgtggttag caacagcctc cacctaaata agcagctccg 1439221 acaatgatta acagaatgaa taaaacaacg attagcgcaa aggtgcggcc gtagccatat 1439281 ccgcagccac catatccgta accaccataa ctgcagcagc ctccgccgta accatatcca 1439341 tacatattac ataacctcct cttttaatta cgccagagcc tttataagta ggcatagcgt 1439401 ctaatataac ctatgtaaaa acaaaaaagt tgtatggtca tctgtcctga tttttcactt 1439461 ttttgattta atttcagtat tgcatttata cagcacggct attgccaaat gtccccatgg 1439521 attctatagt agaaattgtc aagattgggg gatttaacgt gaaagacgct ataaaacggc 1439581 ggcctggaat caagatcgga gctttttgtg ccatggcact gatattaaca ggatgcatgg 1439641 gacaggaccc ggttgattca cttcatcatt cattagaaaa agccgcggaa tcggaaaagc 1439701 cgtttcaaga agaacaaaac acactcaaag aattagaggc caaagaaaat cagctttacg 1439761 atagtgttat gaagctcaat atggatgatt ataaaaaaat tgttgcttta tctaataagg 1439821 cgcttgaaaa tgtcagcaag cgcgaagaac acctaaagct tgaaaatgac agcatgaaaa 1439881 aatcggaaac agaatttgag gaagcaaaaa cgtcagcgga acatattaag gaaaaagaca 1439941 taaaagaaaa ggccgatgcc gcagcaaacc atatggagaa aagatataca tcatatggca 1440001 ctatgtataa agagtataaa aaagcgcttg agcttaataa aaaactgtat atgcagctga 1440061 aagacaaaga tttgacaaga gatgatctgg atcagcagat cgataaagtc aatgcttctt 1440121 atgaaaagat ccttaaatat agcggagaat ttaatgaaca aaccgaaaaa tataataaag 1440181 cccgggaaga tttatatgat gctgcaggct atcgtgtgaa aaagagctga ctcgatcagc 1440241 tctttttttg aatgaaatgc gattcggatt tcgttcaaaa ttttcatttc tattgtagta 1440301 cagcatagta aggtatacta gtacagtttt gggtgcggtt ggcatctgtt tttttgatga 1440361 aaatgtaaag cgaatacatt tattgaaaat cagcgatgaa aacgattgac ggttcttctt 1440421 tatttggtgt aaactaatcc atgttaagcg gtgttgtatt agttttttac aacttcgaaa 1440481 taatacagtt caaagcagag tgtaactatc ctacataaaa ggttttggca aactggggat 1440541 cggctaaaat ataatacgac ttactgctga tactttaggg taccctaagt ttgtatgtat 1440601 aaaaggaatg cacgtctaat gactgtttaa aagaaaggaa gaggtgactt agtatggctg 1440661 caaaaacgaa aaaagctatc gttgacagta agaagcaatt tgatgccatt aaaaagcagt 1440721 tcgaaacgtt ccaaatttta aatgaaaagg gagaagtcgt gaatgaagcg gcgatgcctg 1440781 atttaactga tgatcaatta aaagagctaa tgcgccgcat ggtatttacg cgtgtgcttg 1440841 accaacgctc tatctcatta aaccgtcaag gacgtctcgg attttacgct cctactgcgg 1440901 gtcaagaagc ttctcagatt gcaacgcatt tcgcgcttga aaaagaagac tttgttcttc 1440961 ctggataccg tgatgtgcct cagttaattt ggcacggcct tccattatat caagcgtttc 1441021 ttttctctcg cggacatttc agaggaaacc aaatgcctga tgatgtgaat gccctttctc 1441081 cacaaatcat tatcggtgct caatacattc aaactgccgg tgttgcgcta ggtcttaaaa 1441141 aacgcggtaa gaaagctgtc gcaatcactt acactggtga cggcggagct tctcaagggg 1441201 acttctacga aggaattaac tttgccggag cttataaagc acctgcaatc ttcgtggtgc 1441261 aaaacaaccg ttacgcgatt tcaactcctg ttgaaaaaca atctgcagct gaaacaattg 1441321 cacaaaaagc tgtagctgcc ggtattgtcg gcgtacaagt agacggaatg gatccgcttg 1441381 ctgtatacgc agcaactgct gaagcacgcg agcgcgcaat caacggcgaa ggtccaacac 1441441 taattgaaac acttacattc cgttatggcc cgcacacaat ggctggtgac gatcctacta 1441501 aatatcgtac aaaagaaatc gaaaatgagt gggaacaaaa agatccgctt gtacgtttcc 1441561 gtgcgttcct tgaaaacaaa ggcttatggt ctgaagaaga agaagcaaaa gtgattgagg 1441621 atgcgaaaga agaaattaag caagcgatca aaaaagctga tgctgaaccg aagcaaaaag 1441681 taactgattt aatgaaaatc atgtacgaaa aaatgcctca caaccttgag gagcaatttg 1441741 aaatttatac acagaaggag tcgaagtaag ccatggcgca aatgacaatg attcaagcaa 1441801 tcacggatgc gttacgcaca gaactgaaaa atgacgaaaa tgtcttagtt ttcggagaag 1441861 acgttggtgt aaacggcggc gtattccgtg cgacagaagg attgcaaaaa gaattcggtg 1441921 aagaccgtgt gtttgacacg ccacttgctg aatctggtat cggcggtctt gcccttggtt 1441981 taggcttaaa cggcttccgt ccggtaatgg aaatccaatt cttcggattt gtttatgaag 1442041 taatggattc agtttctggc caaatggctc gtatgcgcta ccgttctggc ggacgctgga 1442101 cttcacctgt aacaattcgt tctccattcg gcggcggtgt tcatactcct gaacttcacg 1442161 ctgacagctt ggaaggtctt gttgcacaac agcctggtat caaagttgtt attccatcaa 1442221 ctccttacga tgccaaagga cttttaattt ctgcgatcag agacaatgat cctgttgtct 1442281 tcttagagca tatgaagctt taccgttctt tccgtcagga agttcctgaa gaagaataca 1442341 caattgagct tggaaaagct gacgtgaaac gtgaaggtac tgatctttca atcatcactt 1442401 acggcgcaat ggttcatgaa tcattaaaag ctgctgatga gcttgaaaaa gacggcattt 1442461 ctgctgaagt tgtcgacctt cgtacagtaa gcccacttga tatcgataca attatcgcct 1442521 ctgtagaaaa aacaggacgc gcgattgtcg ttcaagaggc acaaaaacaa gccggtattg 1442581 ctgcaaacgt agtagcagaa attaatgacc gtgcgatcct gagcttggaa gcacctgtac 1442641 ttcgcgttgc agcgccagat acagtatttc ctttctctca agcggagagc gtatggcttc 1442701 caaaccataa agacgttctt gaaacagcaa gaaaagtgct tgaattttaa tcaaactgca 1442761 taatcgagag ggaagatgaa cgttttccct ctattatata tctgttttca atgcttacga 1442821 tgtaaacttt aaaattgctt aatcaaacta ggaggtcgag aactgtggca tttgaattta 1442881 aacttccaga tatcggggaa ggtatccacg aaggcgaaat cgtaaaatgg tttgtcaagc 1442941 ctaacgacga ggtagacgaa gatgatgtac tggctgaagt ccaaaatgat aaagcagtag 1443001 tagaaattcc ttcacctgtt aaaggaaaag tattagaatt aaaagttgaa gagggaacgg 1443061 ttgcaactgt tggacaaacg attattacgt ttgatgcacc tggttacgaa gatcttcaat 1443121 ttaaaggcag cgacgagtct gacgatgcga aaactgaagc acaagttcag tcaactgcag 1443181 aagctggaca agacgttgcg aaagaagagc aagctcaaga gcctgcaaaa gctactggcg 1443241 caggacagca ggatcaagct gaagttgacc cgaacaaacg cgtgatcgct atgccttccg 1443301 tacgtaaata tgcacgtgaa aaaggtgtag acatccgtaa ggttactggt tcaggcaaca 1443361 acggacgtgt tgtaaaagaa gatatcgaca gctttgtaaa cggaggagcg caagaagctg 1443421 caccgcaaga aacagctgca ccacaagaaa cagctgctaa accggctgct gcaccagctc 1443481 cagagggcga attcccagaa acacgcgaaa aaatgagcgg tatccgtaaa gcaattgcaa 1443541 aagcgatggt taactctaaa cacactgctc ctcacgtaac gttaatggac gaagtggacg 1443601 taacaaacct tgttgcacat cgtaaacagt tcaaacaggt tgctgctgat caaggaatca 1443661 agctgactta cttgccttac gttgtaaaag ctcttacatc tgcactgaaa aaattccctg 1443721 ttttaaacac gtcaattgac gataaaacag atgaagtcat ccaaaaacat tacttcaaca 1443781 tcggtatcgc tgctgacact gaaaaaggct tgcttgtacc ggttgtgaaa aatgcagatc 1443841 gtaaatctgt ctttgaaatt tctgatgaaa tcaatggcct tgcaacaaaa gctcgtgaag 1443901 gcaagcttgc tccagctgaa atgaaaggcg catcttgcac aattacaaac atcggttctg 1443961 ccggcggaca atggttcact ccggttatca accatccaga agttgcgatt cttggtatcg 1444021 gacgcattgc agaaaaagcg attgttcgtg atggcgaaat cgtagcagct ccagtcttag 1444081 ctctttctct cagcttcgac caccgtatga tcgacggagc aactgcgcaa aatgcattaa 1444141 atcacatcaa gcgtttactg aacgatccac aattaatttt aatggaggcg taatgttatg 1444201 gtagtaggag atttccctat tgaaacagat actcttgtaa ttggtgcggg acctggcggc 1444261 tatgtagctg ccatccgcgc tgcacagctt ggacaaaaag taacagtcgt tgaaaaagca 1444321 actcttggag gcgtttgtct gaacgttgga tgtatccctt caaaagcgct gatcaatgca 1444381 ggtcaccgtt atgagaatgc aaaacattct gatgacatgg gaatcactgc tgagaatgta 1444441 acagttgatt tcacaaaagt tcaagaatgg aaagcttctg ttgtcaacaa gcttactggc 1444501 ggtgtagcag gtcttcttaa aggcaacaaa gtagatgttg taaaaggtga agcttacttt 1444561 gtagacagca attcagttcg tgttatggat gagaactctg ctcaaacata cacgtttaaa 1444621 aacgcaatca ttgctactgg ttctcgtcct atcgaattgc caaacttcaa atatagtgag 1444681 cgtgtcctga attcaactgg cgctttggct cttaaagaaa ttcctaaaaa gctcgttgtt 1444741 atcggcggcg gatacatcgg aactgaactt ggaactgcgt atgctaactt cggtactgaa 1444801 cttgttattc ttgaaggcgg agatgaaatt cttcctggct tcgaaaaaca aatgagttct 1444861 ctcgttacac gcagactgaa gaaaaaaggc aacgttgaaa tccatacaaa cgcgatggct 1444921 aaaggcgttg aagaaagacc agacggcgta acagttactt tcgaagtaaa aggcgaagaa 1444981 aaaactgttg atgctgatta cgtattgatt acagtaggac gccgtccaaa cactgatgag 1445041 cttggtcttg agcaagtcgg tatcgaaatg acggaccgcg gtatcgtgaa aactgacaaa 1445101 cagtgccgca caaacgtacc taacatttat gcaatcggtg atatcatcga aggaccgccg 1445161 cttgctcata aagcatctta cgaaggtaaa atcgctgcag aagctatcgc tggagagcct 1445221 gcagaaatcg attaccttgg tattcctgcg gttgttttct ctgagcctga acttgcatca 1445281 gttggttaca ctgaagcaca ggcgaaagaa gaaggtcttg acattgttgc tgctaaattc 1445341 ccatttgcag caaacggccg cgcgctttct cttaacgaaa cagacggctt catgaagctg 1445401 atcactcgta aagaggacgg tcttgtgatc ggtgcgcaaa tcgccggagc aagtgcttct 1445461 gatatgattt ctgaattaag cttagcgatt gaaggcggca tgactgctga agatatcgca 1445521 atgacaattc acgctcaccc aacattgggc gaaatcacaa tggaagctgc tgaagtggca 1445581 atcggaagtc cgattcacat cgtaaaataa ttttcatatc aaaaacagcc ccgctttgag 1445641 cgagggctgt ttttttattt tgacagcaca tgctgtaatg gtttaatgat gtcttctttc 1445701 tttttcacac atccctcgat tttcaccacg acatggcgct gatcaacaac cataagggta 1445761 gggacagttt caatctcatc ttcccagcct tcttttttat catagacctt cattttatct 1445821 atttgctcgg gataatcttt ttctaaatca agcagtgcat cgtaataagg cgcttcctgg 1445881 tctatttggt tctcatcaga aaaaaacagg atttgtgtat gatgaatgtt gtcaatccgg 1445941 ctttttttca tcggattgat ggtggaaagc gtacagcccg ataaagcaaa tactattatc 1446001 agcatgggga ataccgcgcg atatcgcatc tatcttctcc tctgtataaa cagtagttaa 1446061 ctagctttag tttatcacga gagacggctt aatctgcttc ttgttaccta attgttatat 1446121 aattgaaacc gtttttaaag tgagattaca tattatatca atcgtttaaa atagcaacct 1446181 ggggtatatt gaattttttg ctgcattctt ggatgaaagt tcaagaaaac gtgcaattac 1446241 attatgtgct gtggcatata tatcgagtaa agcttctgta tgaagaagat attgtatgat 1446301 ggaaaatgga aaaacaaggt gaatatgatg atatgaaata aaatgtgtta tacagtttgt 1446361 tgttgacatt ttaaatgtga catattaata taataacaac aaaagaaatt aagcgttttc 1446421 aaatttcaaa gaaatgggga ataagagatg ggtacgattg tttgccaaga ttgcaacgaa 1446481 gccattcatt actttgaaga tgagaaagtg acaacattat atggaacttg ctgcggacaa 1446541 tgtcaatgtc ctgttgatga agagtaaaaa aaagcatgcg gcttaaagcc gcatgctttt 1446601 tattttttat tgaattgctt tttgttcttt gatgacccgg atcatatgta aagtcgagtc 1446661 ctcaggtcct tgaacaggga ggcctgcgtc aaggttttta aaaatgtagc tgatgttttc 1446721 ttctgtaata atttctcctg ggatgaagat tggaatacca ggcggatata ccatgacaaa 1446781 ttcagcaata atccgtccgg atgcttcttt taatgggatg acttccgtat ttgcatagaa 1446841 agcatcacgc ggagtcattg ccaataaagg tatttctgga agcagaacct cagtttgctg 1446901 atgtgttaca tcttgttctg acatttgctg tgcgatctca gttaaagcct ctacaagccg 1446961 gtctgcatca ttttggctgt caccaggagt gaaaatacac aaaatattgt acagatcaga 1447021 aagctccacc tcaatattaa aggattcacg aagccatttt tccacgtcat gtcctgtcag 1447081 gccaagactt ttcacagaga taatcaattt tgtcggatca tagctgtaag ctgctttcga 1447141 cccaagaatc tcagaaccga cacaataaat gccttcaatc tgattgaggc gatctctcgt 1447201 ctgattggca agcttgagtg tttcctcagc aagctggcgg ccttctgttg caaggcgttt 1447261 tctggcaaca tccaaagaag cgagaagcaa gtaagaagtt gacgtagttg tcagcatgct 1447321 caggatggat tgcactctgt ctttagatac aaggccttct ctcatgttta aaatagagct 1447381 ttgtgtcagt gatccgccca gcttgtgtac acttgtcgct gctatgtccg ctcctgcctg 1447441 catagccgat agcggcaatt cgtcgtgaaa atgaatgtga acgccgtgtg cttcatccac 1447501 aagcactggc acatcaaacg aatgagcgag ttctacgatg ctttttaagt cggctgcaac 1447561 accgaaatat gtcgggttga tgacgagaag cccttttgca tccggatgct cggtaagcgc 1447621 ccgtttagca gattcaagtg taattccgtg ggagatgccc aattcattgt caatttcagg 1447681 atgaataaaa attggaaccg ctccggaaaa tacaatagct gtcataattg atttatgaac 1447741 atttcttgga ataataattt tatcaccagg tccgcaaaca gccattacca ttgtcataat 1447801 ggcgccgctt gttccttgaa cagaaaaaaa tgtatgatcc gctccaaatg cttcagcagc 1447861 cagatcttgt gcttgtttaa taatgccttt tggcgcgtgc agatcgtcta atggttcaat 1447921 attaatcaaa tctatgctta acgcgttttc accgataaat tgtctgaatt ctgggtccat 1447981 tcctgcccct tttttatggc cgggaatgtg gaattgaaca ggctgtctgc ttgcatgctt 1448041 tttcagtcct gtgtataagg gtgtttcatg ttgcgacaat tgttttccca cctttgtaat 1448101 catacctatg cataatagtg tgtattaaaa tcagtttctc aaccgttttt tagacgtaaa 1448161 acaaatgaat tatattatga acttgaaaga atgtaaagaa caatttatga tcaaatgaag 1448221 atgctttctc ttaagggaag taaatctaca aggagtgaag aaaatggagt atcaatatcc 1448281 gatgaatgaa gattggacaa ccgaagaagc agtggatgtg attgcatttt tccagcaggt 1448341 tgagcttgca tatgaaaaag gggcggatcg tgaagaactg cttaaagctt accgccgttt 1448401 caaggaaatt gtaccgggga aggccgaaga aaaaaagcta tgcggcgagt ttgaggaaca 1448461 aagtacatat tctccttatc gcacggtcaa acaggcgaga gaatctgatc acgcgaagat 1448521 taagatgtaa gaaaaagagc cgggggatat cccggctctt ttttatgctt gtgttacttt 1448581 ttgggtgaga cggtacagaa aagcaagctg tttaaaggca tcgtcgatac gctgaaggaa 1448641 ttcctggtta ttcatattca gcacttcttc tttttggagc tggatgccgc ataacagctc 1448701 ggctttcttt acagtctgca aacgctcaaa cagtgtcttc agctgttcct tgtccatttc 1448761 agactgttta tgtactcccg gttttgtgtg atctgcagac caaacgaagc tgtcagggat 1448821 atttttcgta atggtttctt ggttcacttc aagcaatttg ccgtattctt ctttgatagg 1448881 ggattcataa ataatcgcga accatacaaa gacgtggctt tcccataaac caatttggaa 1448941 atgcggcagt tttttatagc ctcttttgct gtttgcgaac gccacccagc tgtcagccgg 1449001 gggattgacg gatcttcttg cgtgctttgc cacatgcgga aacatttcat ctccggttaa 1449061 agctgataaa gttggggcaa aatgttcgcc tagagctgta agcttcggac ggaccgtctc 1449121 ttttaatact tccatgcgcg cgtctaagcc ttctattgta aatgtgttaa agtcttcttc 1449181 agtgaaacgc atttgtgtca tgattttcct ccttcatgct aagtatacat attttatcac 1449241 agttcatacg agcttcaaaa agattgagcg cgtttgaagt aaggagaaat gtggtaataa 1449301 acgagtaggt aaacacacaa ttttcagaat catgttgcgc gtaaatagaa caatcatacg 1449361 atataagaag taatcattgt tgaatggcaa aatgggatgc ttttttacaa acaaatgatc 1449421 tctggaaggg gcgaaagaca atgaggcaag ttgtaaaaga gggatttaag gaagagaaaa 1449481 acaatcgtgt tgctgtctgg agactagagg ttgattatga attggcaacc ctatatgaag 1449541 caatgcagaa agaaaatgaa gagcagattg aacaaagcaa aaacaaactt gagcgactta 1449601 gaaaagaatg gattcgtctt aacgggtaaa aaagcgatag tgaaaacgaa ccgcatgaat 1449661 ggttcgtttt tacgtgagaa gggatatttt tcattttcct tgctttttca ttgccgttat 1449721 cagtatccta taaaataaaa ggtctacata gaagagaggt acgaacgaat gacaaattgg 1449781 acggaaatcg atgagattgc aaagaaatgg ataagagaag caggcgcgag aattacacaa 1449841 tccatgcatg aaagcctgac aattgaaacg aaatcaaatc cgaatgattt agtcaccaat 1449901 attgacaaag aaaccgaaaa gtttttcatt gatcgaattc aagaaacatt tccgggacat 1449961 cggatactcg gtgaagaggg gcaaggagac aaaatccact cacttgaggg agtcgtatgg 1450021 attattgatc cgattgatgg gacgatgaat tttgtgcacc agcaaagaaa ttttgcgatt 1450081 tccattggga tttttgaaaa cggtgaaggt aaaatcggtt taatttatga tgtggtgcac 1450141 gatgagttgt atcacgcatt tagcggcaga ggagcttata tgaatgaaac gaagctggct 1450201 ccattaaaag aaaccgtcat tgaagaagcg attcttgcca ttaatgcaac atgggtaacg 1450261 gaaaacagaa gaattgatca aagtgtgtta gcgccacttg tgaaaagagt cagaggcaca 1450321 cgctcctacg gttctgccgc tttagagctg gcaaatgtcg cggcaggaag aatagatgct 1450381 tacatcacga tgcggcttgc gccatgggac tacgcagccg gctgtgtgct gttaaatgaa 1450441 gtaggaggca cctatacgac cattgaagga gagccgttta cctttttaga aaaccacagt 1450501 gtgctagccg gaaacccatc tatacataaa acgatatttg aagagtatct tcatgctcgg 1450561 aagtaggcca tttgagcagg atgatctcag cttgttagaa aagctcgcgg aggctcatcc 1450621 tgtatggaaa gaggaggagt ttggagataa agatgcagaa gactatatca tttcctactc 1450681 catgtacaac ggttcatggc ttgtatggga aaaagacggt atgcctgttg ccgtcagcta 1450741 ccatctcgag tggtctcctt caaacggtaa gccgtggctc ggaacggtcc tgattgaccc 1450801 ggctgaagaa aaaaagggac atgcgaagat gatcattgaa cagatcagca aattgcttag 1450861 agcgaaacat aaagcgatgt ttgcgggagt tcccattgag cgcagggaat ggatactgtt 1450921 tttaagccaa tgcggctttg aacagctgaa aacggaaaaa gatgagaaag gcaaatcatt 1450981 tatgatcttg gtgaagcctt tagcagaagc tgccgtatga taatggcagc ttatttgctg 1451041 catgcgggtt caataaaaag cctctcaaac attgagaggc ttctgatgat ttgaaaatta 1451101 tttttttacc gcatgaatat aatgaatcgt ttcaaacgct gacaaattgt cttttcgatt 1451161 actaaagaaa aggtcattga tgtcgtctgg tgatagatgt tcatagatca gtaaaccaga 1451221 tgactctaac agatgttcaa tctcttgata agtgaaacat gatttcatcg gttccccgct 1451281 tgcggcagcc atcttcacca tatgttcaac tcgattcgac gtcccttttg ctgtaaaaag 1451341 tgtttcgtcc gcataatcaa aaacaataga gcttccaggc gggacatgag aaaataaatt 1451401 gctgatcaag cttgcatttt cttcccgtgt tacataataa gacactccga gaaggctgaa 1451461 gaatgttttt gtgtttttaa atccttcatc taagagagga tcatacgaaa acgttttggt 1451521 gaaatccata ggaacaaaat gaagatgacc cggaattgtc agatttgcat ccttcagctt 1451581 attttttttc aattgctgtg tggccggatg atcaacctcg aaaacctgta agctgttttc 1451641 taattctgga tgccgaaagc agaaagtatc cagtcccgct ccaagaatga catactgttt 1451701 tgcccccagg attaattcgt tgtgcaagac tttttcacaa taagaagcac gtgctagggg 1451761 cgttggagac agctggattt gtgcaaccca ttttaatatt ttttcaggat cattttgaag 1451821 acgttcggcg atctctttgt tgaaaaacga tatttcttga atcatatttt tactgatgtc 1451881 gataaactct ttttcgttaa tgagatcttt tgcgataaaa tcatcaaaaa taagaggtgt 1451941 gtcatatcgg ctgtgatatg cacgggcaaa agctgaaatt agagacgtta agctggactc 1452001 atttttcctc atgaaatgat cctccacaaa aaataagatt cccctggcca ggagaatctt 1452061 attatacata caaatatatt aatagtaaat tttagcataa ataaattttt ttgtcaatgt 1452121 ttttgctctt aactggacgc gcgatccttc acatagccac gtgacctgta gcagaattcg 1452181 tctatcaatt atgtggactg aatcattagc ttttataaaa tgcgcacttg cggctgcatc 1452241 cctctttatg caaatcagga gcggttttct gtctcatggc agcatctttt cgtcgtttca 1452301 gctgagagag aaatcaagat atgtaacaat aaaagcctga gggatctcag gcttttccta 1452361 atattacaat ccaacagcat tccaggctgc ttcaacttta gcggcatcag ttgagccgta 1452421 gaggtcacgg gcagactgaa tgagagctgc cttggcatct ttgaacgtgg aagaaggcgt 1452481 gaggtacgtt gttaacgcac ggtaatagat ttgctgtgat ttagatacac caagttttgt 1452541 gatggtgttg taagcggctt tgtttggaat tccgctgttt gtgtgtacac cgccataatc 1452601 gccttcatct gtgtttggaa ggtttcggta attggcgtaa ttgtcaggct ggttgtattt 1452661 tgtagggttg gacaggctgc gaagagcagg ctggctgacc gtaatgtctt caccgatgtc 1452721 ccagtcttct gtatcgttaa aatacccgaa tacgtcagag aaagactcgt ttaatgcacc 1452781 tggctgattt tcataaatca agttggctgt ttcttgggtg acgccatgtg tcatttcatg 1452841 cgctgtcaca tctaatgagc cggaaagcgg agagaagaat gaaccgtcgc catcaccgta 1452901 aatcatctgg tctcctgtcc atgcagcgtt attgtattga gtgccgtagt gaacggaaga 1452961 aacgatttta ctgcctttgt tatcatagct gtttcgttta aagtttgaat aaaaataatc 1453021 gtacacttta ccgaggttat agtgtgcgtc aacggctgcc cgctgtgatg aagatgtaaa 1453081 tgttttcgtt gtgcttgaga caagcgtgcc cggaaggcgg ctttgtctgt tttgcaaatc 1453141 atatgtgatg atttgggtgc ctgttggttt tgaaagatct cttagaacat attttccgcc 1453201 ttcataagag atgttcaaag gaacagttgc gccctttagc gttgttccgc ttccagtggc 1453261 ggcggcatgt tctactttat tttgctgttt taaaatgctg cctgtttcgg cgtcaactaa 1453321 gacttcccag tttgcaggtt caggctcgac atagcgaatc gtcacgtcgt aagcaagacg 1453381 atagctgccg tcttttgttt ctatcgcttt taattcggct ttattgctgt ttttggccgc 1453441 tccgttagaa acagcgtctg gtgatttgcc gatagctttg aaagcgagtg ccagcgcttt 1453501 ttcagaagag actttttggc tgttatctgt ttttgcagca gattgattgt gtaattcacc 1453561 attgaccgca tagacattat cggatttatc gacgtgaacg atcacttgcg aatctttaat 1453621 tggcactccg ttaacgacag gcgcatatcg aaagtgcttg tatccaaggg catcagtcgt 1453681 gctttcaaca agcttcagcc ttttggaagg gtcaccttta aaaatgttgc tgttcttttt 1453741 caaaaactgc ttgacagcct tgtcatttgg tgcagagagt tctgattgcg caatcgcgtt 1453801 tttggagagg aaatttgttt gattctcttt aagctgatga ccttcagcag cctgaacacc 1453861 tggcaggctg attgataaac tcataaacga agcagcgaca gcaacagaca atttcttacc 1453921 taaacccaca ataaatcccc ctttttgaaa atactgaaaa ctttatattg ttatattaaa 1453981 ctagcattct ggaatactca acaaaaacta acataactag acaaaattga tagtattgtc 1454041 ctgtgtttgt ttttgttgaa taatatcaag atgagtcaag tgtcatgtgg tggttcattc 1454101 aagagttatg ttttttacat atcaagggga agatgagata tttttgtttc atcttgaaac 1454161 tttttgaaaa gtccgctgtc taaccgaatg aggccttaat aagaagtaaa ggattgttgt 1454221 tcgtgttgga gttattcagt cattatgtat tgcatttcga acgttatttt atattaagca 1454281 gacaaagcac cctgctgatt caatggtcaa ttgttgttct ggcgggctta tatcttttgg 1454341 tgcatcatcc caaaataaac cggcagcgca caatgttctt ggcgggtgtt atattgcgga 1454401 ttgtgctgct ggcgggagtg tctgttgaac ttattcacca ggtgcaatca acaaacttca 1454461 ccagcgctta cttaagagag gacggaaaag aactgctgcc gctgctgcat tttttgttat 1454521 acggatatgt gctgctgacg gcttttcact atatgctgat gccgcgtgat catggcggaa 1454581 agggtaagtt ttatacgttc gaccttgctg ttgtcagttt gccgatcgta caaatgattt 1454641 ttagtttctt ttcgtattgg aaggaatacc cggatgggat ggagccgatt gcattcgtgt 1454701 ttctgttttt catcatcact cttcccattg cgttgaatgt agtgtttttc aagctgtatt 1454761 ggagaacgga taagatctta ctaggcttat tttatacgct gattatcgga ctgcttgtct 1454821 tgctgcttgc gccatatccc aatcaaatct caaaagatta tggtgcagta atgccatata 1454881 cgatttattt ggcaatggcg ggatttttga tgagctatca tctgttccaa aagtcaggaa 1454941 aggtttatgt gcgtgtgaat aagtgggtga cgatggctgt catggtgttt tttgtcctgc 1455001 tgttaaatcc gatatataac ataggaacgg ctgctttcgc tgtatcaaag ccagcaaatg 1455061 tccatgattc attcaatttt gtcggggagc acatttcatc agaaaaagcg gaacagatac 1455121 taaagtcatt ttttcctacg gatgaaacac tttatttgca cgatacaaac atggatgtgc 1455181 attatttcta ctcatttgaa agcaaaggtt acaaagctga ggtagatgaa gtatcgcagc 1455241 taattcgtaa ttatgaatac ttacaaaaag cacatgggaa aaagctaacg aatcaggagt 1455301 acaagcgaaa gtccatcgct ttccttgagc gacacggacg tgtgttacat aaggatcata 1455361 tcgaaacaaa ggtatctcaa gaagacggcc agacagtcgt acgtatttac ctgaaaaatc 1455421 aacttcataa aaaagatcat gctgatgatg gcgcggtatt ttattgggaa aaggaaacct 1455481 taatggggtt tagtgaagat ccttcgattt atcagcttga ctctcttctg catgttcata 1455541 taacggaaca agacattcac gacaaagtgg aacaaatgtt tacagcgctg aacatatcaa 1455601 aacagcctta tcagatcact gatattgaaa gcgacagcct gcttggaagc atggtgagag 1455661 ttgaaacaaa agttggaatt gttttggaat ttgagggcga atcaggttgt ttacatagtc 1455721 tttcgcttcc gatgaaaaag aatatctcaa tggctaacag ccggctgcag catcagatat 1455781 tatcgatctt cgatgctcgt ggatcagaaa agaagaaaaa aagcagtcag ggtgacatgg 1455841 tgatgtatac tgattcttct aaaacatatg agtttgttga agctcaaggt cagctaaacg 1455901 tttatgtata cagcgataca cctgatcagt cattccccta tacgtatcgt aatggaacat 1455961 tggcttacga aaaagtagct tctctatatc aggatgtcat ttacaaaaag cgtatgcgtc 1456021 cgattatcgt tcaaagaggg gatgaacggc attatgcatg gctgatcatt attcagccgt 1456081 ttggttcaaa tcgccatgat gcctatgtag tggatggaga aacacaagag gtgaaaagtc 1456141 tttatgaatc ataaagaaaa agagtctgtt tttgtagact tatacgacct gtataaagaa 1456201 ggagagctag aggatgaatc aatggaatgg atgaaacagc atgaatccct atttcaaaag 1456261 aatgcggaag acttaaagag taaaacttgt ttaaagagaa gtcccggtgc tgaagaagaa 1456321 agccaaatca gatatatgaa agtatacctg tcttccatgt atatctgttt cattttattg 1456381 gccatttgga tgacggtgtg gttttatttt taatgaagca tagggattcc attgaggact 1456441 tgtatcggca gtattatcaa gaaattttaa attatttatt cagaaggact catcatcttg 1456501 aaacagccaa ggacttagcg caggacacgt ttgtaaaagc tcttaacggt ctggcttcgt 1456561 ttagggggca ttcttccatc agaacatggc tctacaccat tgcgcatcat acctttatca 1456621 attggtaccg aagggatgtc aaataccaat ttactgaaat cagcaaaaat gaagggttaa 1456681 cgcaaacaac ttatgaccag cctgaacagt atctgtcacg gacggtgaaa agcgaaacac 1456741 tgcggcagga gctcctgaag ttaaaagatc agcatcaatc cgttttgatt ttaagagaat 1456801 tccaagagct ttcttatgaa gaaatcgctg agatattagg atggagtctt tctaaggtga 1456861 ataccacatt gcaccgggct agattagagc taaagaaaaa catgacgaaa agtagagagg 1456921 aggagcggat atgacctgct ttctagtaag agacctgctt cctctgtatc ttgaaggtga 1456981 ttgtaaaaga gaaacggaac acgttataga agagcattta aaaatgtgca gcagctgcag 1457041 agacatgtat gacacgatgg ctgagccatt tgaattggaa agcgaacagg ccgttgagga 1457101 ggcttatctg ccggaagaag aactgcgttt taaacagagg tactatggat tactgatcat 1457161 gaaagctgcc tgctggtttg gagcggcggt tgccatgatg ctgatcatca aactgctgat 1457221 ataaaaaaag cgcttgtccg attccggcaa gcgctttttt acattaagcc tggggatgaa 1457281 tcatatcgta aatagcggca agctgttctt gtgacagggc actgaagagt ttttcataaa 1457341 cgtcagcttg cagtggcgtt gcacctgctt gtagcgctgc gtctttatca tagctgtaca 1457401 catcatcttg tagcacaatg gctgcttgaa gaatgtgaat cttgagagaa acagcggaga 1457461 aaaattgttc aagtgcaagt gcttcttttt ctgtgaagcc aagttcaact gctttttctg 1457521 tatcaaattt gtaatttcca tcctcgagat acacacattg tgaaacaatg ctgaaaaatt 1457581 ctgatgtcga ttcccagagt gtagcaatta cctgagcctc ttcttttgtc attcctaact 1457641 cgacagcttt ttcgctgtca aaataatata caccgtcttg ttcgtatata cattgattta 1457701 atatatcaat gaatgtattg agatcttcgt tagtgctcgc ctgatgctgg agttgaacag 1457761 cagtgttatc aaccggtgtt tttgcgctgg ctgcatcagg accgaacgtt aatagagcag 1457821 ctgaggtcat tgcggcagtc gttaacatag ctttttttac aaatgttttc ttcatgtttc 1457881 ttctctccct tttatgaatt gtgctacaaa ttccattata gggagtagtt tccggtggag 1457941 gaataggcgc tatggtattt tatgtgtatc gttgccgaac tactttttga aggctgcacg 1458001 tgtgatcgtt agaacgattg tctatgtatg aaggctgttt tgcatcttcc tgactaagaa 1458061 acaggggaga taaggcttaa agaaatgaaa aacaccgctt tctttgcggt gttttttgat 1458121 tacaatgtcg ccggcggggc aatgctttta atcaagcaag ccttgttcgc gcattttctt 1458181 ttttaatgta aatccgccgc ccatgacagc gcaaacaagt acaatgctgg cgataatgcc 1458241 tgcagggctt ttttcagcga taaagacgcc gatcagcata atgctgaaaa ccgctgcaaa 1458301 tgcaaataat agtaaaagcc aattcatttt tttcataaat tccatcccct tttacgtctt 1458361 atattaagtt tacagaaaaa cgtgacgctt ttaaagagga tgtgtgatat aatatgaaag 1458421 ttatctaatt tttttaggag atgaaaaagt gaaacttcga aatgatcttc gcaacatcgc 1458481 gattattgcc cacgttgacc atgggaaaac gactctagtc gatcagcttt tacatcaggc 1458541 tggtacgttc cgtgccaacg aacaggttgc tgaacgcgca atggactcta atgatcttga 1458601 acgcgaacgc ggcattacaa tattggcgaa aaatactgcg attaactata aagatacacg 1458661 tatcaatatt ttggacaccc ctggacatgc agactttggg ggagaagtag aacggattat 1458721 gaaaatggtt gacggcgtag tgcttgtcgt tgacgcatat gaaggctgta tgcctcaaac 1458781 tcgttttgtt ctgaaaaaag ctcttgagca aaacctgaac cctgttgttg ttgtaaacaa 1458841 aattgaccgt gactttgctc gtccagagga agttatcgat gaagttctgg atctgttcat 1458901 tgagcttgat gccaatgaag agcagctcga gttcccagtg gtatatgctt ccgcgattaa 1458961 tggaacagcg agtcttgatc cgaaacaaca ggatgaaaac atggaagctt tatatgaaac 1459021 cattattaag catgttccgg cacctgttga taatgcagag gagccgcttc aattccaagt 1459081 tgcccttctt gactacaacg actatgtagg ccgtatcgga atcggacgcg tattccgcgg 1459141 cacaatgaaa gtcggacagc aggtttctct tatgaagctt gacggaacgg caaagtcatt 1459201 ccgtgttaca aagatttttg gtttccaagg cttaaagcgt gtggaaattg aagaagcaaa 1459261 agcgggagac ctcgttgcgg tttccgggat ggaagatatc aacgttggtg aaacggtatg 1459321 tcctgtagac catcaagatc cgcttccggt ccttcgcatt gatgagccga cacttcaaat 1459381 gacatttgtc gtgaataaca gtccgtttgc aggccgtgaa ggcaaatatg taacggcccg 1459441 caaaatcgaa gagcgtcttc aatcacagct tcagacggat gtgagcttgc gtgttgagcc 1459501 aacagcttct cctgatgctt gggttgtttc aggacgcggt gagctgcact tgtcaatttt 1459561 aattgaaaat atgcgtcgtg agggctatga gcttcaagtg tcaaaacctg aagttattat 1459621 caaagaaatc gacggcgtac gctgtgagcc tgttgaacgt gtgcaaattg atgttcctga 1459681 agagcatact ggctctgtaa tggaatcaat gggtgcccgc aaaggcgaaa tggttgatat 1459741 gatcaacaac ggaaacggcc aagtccgtct catctttaca gttccttccc gcggattgat 1459801 cggttactct acagaattcc tatcattaac acgcggattc ggtattttga accatacgtt 1459861 tgacagctac cagccgatgc aggcaggcca agtcggcgga cgccgtcaag gtgtacttgt 1459921 gtcaatggaa aacggaaaag caacatcata cggtattcaa ggaattgaag accgcggtgt 1459981 catcttcgtt gagccgggta ctgaagtata cgaaggaatg atcgttggag agcataaccg 1460041 tgacaacgac cttgttgtta acgtcagcaa aatgaaacag caaacaaacg tccgttctgc 1460101 gacaaaggat cagacaacta caattaaaaa agcgcgcatc atgtctcttg aggagtctct 1460161 agagtactta aacgaagatg aatattgtga agtaacacct gaatccatcc gtttaagaaa 1460221 gaagatcctc aataagaacg aacgtgaaaa agcagctaaa aagaaaaaaa cagcaggatt 1460281 gtcttaatct cgtgcagaat ttgaaaagat agaacccgta cgtttacagg ggagggaatc 1460341 tttttgaatg acgtaagcga acgcctgtcg ttcttcgccg ctctatatca agtagaccgg 1460401 cagcctgcgg caggcatgtg gctgctgtac ggcacgattt ttgtgttggc cgttattgta 1460461 tttaagcttg gatttgctaa acggcttcct gtattaaaat ctgcagtggt gtatgtattt 1460521 ttggctttgg gctgcactgt tttgactttt ttaggggtgt ttttgcccgt ggcagaagga 1460581 ttggtcgtcg ctgcgctgat tttaatcatt tacaaaatcc ggctgtatca gtcgaaaaaa 1460641 ggacagtctg caaaatcata aaagactcag ctgaaagctg agtctttttt gtgttctgta 1460701 tggttaagcg gccgctttat tttttgactt tttctttttt ctgctgtccc gggtgaaaag 1460761 taaattttcc cgttttcagc cgttcctctg tttttttggc aatccgatcg tggcattcct 1460821 ggcacatata tgtatggatc gggcggtttc gaagccgttt cgcgatcagg gtatcatcat 1460881 caattgtttc aattttatcg caaatagaac atttgaccct catcatatca cctctttcac 1460941 taacatgtat tataccacgg atcagaagct gtccaaaata agaaaaagct aaagcgcaag 1461001 gctatagctt agtcattgtt gttctttttc atatgatgat cagattgatc gttttgttcc 1461061 ttctccattt cctgttgctg ttttctattt aattggtcat tttgctgctt tgtttgcggt 1461121 tcatcttcat tgtcaatcac atcgttaggc acttcgggaa gcactcggcc gacaattgca 1461181 gctaattcat ccagtatacc tgttaccgga tggccctcgc tgatttctct gctcatttcg 1461241 cgaaggcggc tgaccgtatc gggatcagca atgactactg cgttggcgcc atatcgatca 1461301 ttctttagcg cctgagctac agaatattta atggtttcca ctttgcttct gtccaaagta 1461361 tcatcgacat caatcccaac aacagcatag cctcccagca caacggctgt tgcatccttg 1461421 acgtcggggt ttttttcagc aacgctgaca agatgcttgg caatatccgt tcttgttcca 1461481 ttgtcttttg tttcttgagt tgtgtccttt acgtgaatcg gtttagtctc ctgctgtctt 1461541 gttgattctt tttcaacatt ctggccctgt tttccttgtt gataggcaca agcggacagg 1461601 ataagtgtca gctgtatgat aatgaaaaga attcgcactt gcgggttccc tccttaaaat 1461661 gctttcatta attttattgt tgaattaacc ttctatcttt atgcacaaaa acatatattt 1461721 tagcaggcat tcaccttttt catcaaaaga gaagcaggaa gaactttgac ccttatatca 1461781 ggaggctgag acttgagtaa aatttatgtg ttagatacga atgtgttatt acaggatcct 1461841 aacgcgatat tttcttttga agaaaatgag gttgtcatcc ctgctgtcgt tttagaagag 1461901 gttgattcaa aaaaacggta tatggacgaa gttgggagga atgcaaggca cgtatctaag 1461961 ctaatcgatg cgctaagaca aaagggcagg ctgcatgagc atgtaccgct tgacaccggc 1462021 ggcacactga gaattgaact gaatcatcgt tcgtttcacc agctgcaaga gatctttatt 1462081 gaaaagacga acgataatcg catattagcc gttgcgaaaa acttaagcct cgaggaagaa 1462141 accaaggaaa atggcaggcc ggttatcctt gtcagtaagg atgtactggt cagggttaaa 1462201 gccgacgcaa tcggactgct tgctgaagat ttcttgaatg accgggttgt ggacaatgat 1462261 gaaatgtaca gcggctataa agatttatat atcagccagc agctgttcag ctctttttac 1462321 gggaaaaatc aaatttcagt aaacgatgtg aaacagcatg cgttttatcc gaatcagttt 1462381 gctttaatga aggatgagct aggagggtcc tcctcggcag tcggaattgc agacaaaacc 1462441 ggaacggtat taaaaagact cgtatttgat gatgaacata tatggggaat caggccgaaa 1462501 aatgtacagc agacaatggc attagagctt ttgctgcggg aagatattcc gcttgtcacc 1462561 ctgatcggca aagcgggaac cggcaaaacg ctcttagctt tggcggcagg gctattacag 1462621 acagaagact tgggaatata taaaaagctg gtcgtcgcaa ggccgattgt tcctgttggc 1462681 aaggacatcg ggtatttgcc aggcgaaaaa gaggaaaagc taaagccttg gatgcagccg 1462741 atttttgaca acttagagtt tctgtttaat gcgaaaaaac caggggagct tgatgctatt 1462801 ttggcgggaa ttggctcaat tcaggtagag gcgctgactt atatcagagg gagaagcatt 1462861 ccagatcaat ttattatcat tgatgaagcg caaaatttga ccaggcatga ggtgaaaacg 1462921 ttgctgacga gagtcggtga gggcagtaaa attgtcttaa tgggcgaccc tgaacaaatt 1462981 gatcacccat atttagacag tctgaacaat ggtttggcct atgtggttga gcggtttaaa 1463041 ggacaaccca tctcaggcag cgtgaagctg ttaaaaggtg agagatcagg tctcgcccag 1463101 cttgcagctg atttgctgta acacttaaat gatttcgatc tcttttacat cggtaatcgg 1463161 ctgtttgtga tgaaccgggt cttcaaagta aatatgcacg gggccgcctt cttgaatcgg 1463221 cttgcctgcc tcactgaaat ggacaatact gttcagagcg gtttccagag aaacggcggc 1463281 ctttcccgaa cttgtgacaa atacacattg tgtcgcagag ctgttcggct cagcattttt 1463341 caggacagtc ccaagtctca ttgcgaaact gccgttcatc agtttttgct tctcatattg 1463401 cttttccgtc tttaatgtag gcggcgcgat tcgcccctct ctgatgacgc gttccggatc 1463461 aaggtcggat tcatccccgg ctgattgtaa atatgtgtct tgactgtccc ctttgcggtc 1463521 aaacgaaaat ttgcgatcat caaaaatcca tacgcttgga tcaatggtaa ttggatatgt 1463581 aacattgcct tttacttgga taacgctcat gatatgaccc ccttctctca aaattataaa 1463641 agttttcgca tgaattgtca ctttgtgtac aaattatgtg tattgaaatg ctgagggaac 1463701 gagggtgttt gcatggtatg ccagcataat gatgagcttg aagccttagt gaaaaaggcg 1463761 aaaaaagtaa cggacaaggg ggaggtagcc agctatattc ccgccttggc aaaagctgat 1463821 aaacacgacc tgtcagtggc gatttattat tccaataatg tttgtctgtc agcaggtgac 1463881 gtagaaaaaa catttacgct tcaaagtata tcgaaagtcc tttcccttgc tttggtgtta 1463941 atggaatacg gcaaagataa ggtcttcagt tatgttggac aggagccgac cggtgatccg 1464001 tttaattcaa ttatcaagct cgaaacagtg aatccgagca agccgttaaa ccctatgatt 1464061 aatgccgggg cattggtagt gacaagtctg ataaggggaa gaacggtaaa agagagactt 1464121 gattatttgc tttcttttat cagaaggctg acaaacaacc aagagattac atactgccgg 1464181 gaagtggctg aatctgaata cagcacttca atgattaatc gggcgatgtg ttattatatg 1464241 aagcagtacg gcatttttga agatgatgta gaggcagtaa tggatttata tacgaagcaa 1464301 tgcgcgattg agatgaacag cttggattta gcgaaaatcg gatctgtatt cgcattgaac 1464361 ggcagacatc cagagactgg ggagcaggtc atctcaaaag atgtcgctag aatttgcaaa 1464421 acgtttatgg tgacgtgcgg aatgtacaat gcaagcgggg aattcgcaat taaggtcgga 1464481 attcctgcga aaagcggcgt atccggcggg ataatgggca tttcgcctta cgatttcggg 1464541 atcggcatat tcggccccgc attagacgaa aaagggaaca gcattgcagg tgtaaagctt 1464601 ttggaaataa tgtctgagat gtacaggctg agtatttttt aatttatgtc atatgcttaa 1464661 atcctcttgc attttctgtt gatacccttt atgataaata gaagaattag gtactcgcct 1464721 ggggaacgga gggatacttt tggcttcaga gatgatagtt gaccatcggc aaaaagcttt 1464781 tgaactctta aaagtggacg ctgagaagat tttgaagctg atccgagtac aaatggataa 1464841 cttaacgatg cctcaatgtc ctctatatga agaggtttta gatactcaaa tgttcgggct 1464901 ttcgagggaa atcgattttg ctgtccgcct gggattggtt gatgaaaaag acggtaaaga 1464961 ccttttatac acattggagc gcgaattgtc tgctttgcat gacgcgttta cagctaaata 1465021 aatgataaaa ctcaaactta ttaacagttt gggttttttt ataaccgcta tttttctctc 1465081 atctcataaa agacggtctt tttttacaca ttccttccga atcgtataga gattcttcgt 1465141 ctcgtttgat aaattgtagt aaaataaaaa agataaatac ataaaaacca tagataatgg 1465201 aagttagaag cagggaagag gatgttatgt taaaaaaaat gctaaaatct tatgattact 1465261 cactgatatt cgcaatcgtt ttattatgcg gattcggttt agtgatggta tacagctcaa 1465321 gcatgattac ggctgtctcc cggtatggag taagcagtaa ttttttcttc atgcggcagc 1465381 tgtttgcttt aattgcgggt ggcgctctat ttattctcat ggcgttgttt ccttataaag 1465441 cactggccca tcaaaagttt cagaagggga tactgcttgt atctgttctt gcgcttatct 1465501 cactgtttgt tttcgggcat gttgccggaa acgcgcagag ctggtttaaa atcggcggaa 1465561 tgagtattca gccgggggag tttgtgaaac tggtcgtgat tttatacctt gcagccgtat 1465621 atgcaaaaaa acaaagttat atcgaccatc tgttaacggg agtagcccct ccggtagtca 1465681 tgacgcttat aatttgtggg ttaattgcca tgcagccaga tttcggtaca gccatgatta 1465741 tagggttaat tgcgacgtgc atgatcttgt gctccggctt cagcggaaag acgctggtga 1465801 ggcttgtgat actgggcgga attgttttca ttttagtcag ccctattatc tatttgaatc 1465861 aggacaaaat tttaactgaa ggccgtttag cgcgttttga gagtcttgaa gacccattta 1465921 agtatgcaaa ttcatcaggt ttgcaagtga tcaattctta ttatgcgatc agctcaggcg 1465981 gcattttcgg cctggggctc ggtgaaagta tccaaaaata cggatatctg cctgaatcac 1466041 acactgactt tattatggct gtcattgctg aagagctcgg catttttggg gtattgtttg 1466101 tgattttctt attgggtttt gtcgtcataa aaggttttta tattgccaga aaatgcgagg 1466161 acccgtttgg aagtcttctg gcgatcggca tttcaagcat gattgccatc cagtcgttta 1466221 ttaaccttgg cggtgtcagc ggattaattc cgattacagg ggttacgctg ccatttatca 1466281 gttacggggg ctcttctttg gtgctgctgc tggggagtat ggggatatta gcgaatatca 1466341 gcatgtttgt gaaatattca gagaataaga aaaagaaaga gcccttggcg ccgaagggaa 1466401 tgaaaaagaa acagctcaaa aaaactgttt atctgtaaaa aacaagtgtg tacaggggaa 1466461 ggatattccg ctatgataga ttatattcca ttcgggtaag ggggagaaaa gtttgtctca 1466521 gcaatcgata caaaaagtat tagtagcaaa caggggagaa attgcaatcc gaatattccg 1466581 ggcgtgtacc gagttgaata ttcgtacagt tgcggtctat tcaaaagaag attccggttc 1466641 ctaccatcgg tacaaagcgg atgaagcata cttggtcggt gaagggaaaa aaccgattga 1466701 tgcttacctg gatattgaag gtatcattga tattgcgaaa agaaacaaag tcgatgcaat 1466761 tcatccggga tacggtttct tatctgaaaa tattcatttt gcgagacgat gtgaagaaga 1466821 aggcatcgta ttcatagggc caaaatccga gcatctcgat atgtttggtg acaaggtaaa 1466881 agcgcgtgag caggcagaaa aagcgggaat ccccgtgatt ccgggaagcg acggtcctgc 1466941 cgaaacgctt gaagccgtcg aacaatttgg acaagctaac ggttatccga tcatcattaa 1467001 agcctcgctt ggcggcggcg gccgcggtat gcggattgtc agatctgaaa gtgaagttaa 1467061 agaagcatat gagcgtgcta aatcagaggc gaaagcagcc tttggcaatg atgaagttta 1467121 tgtagaaaaa ttaattgaga atccgaaaca tattgaggtt caggtcattg gagacaagca 1467181 gggcaatgtc gtccatcttt ttgagaggga ttgctccgtt caaagacgcc atcaaaaagt 1467241 cattgaagtg gcgccgagtg tctcgctgtc acctgaatta agggaccaaa tttgtgaggc 1467301 tgcagttgcg cttgccaaaa atgtaaacta tataaatgcg gggacggtcg aattccttgt 1467361 tgcaaacaac gagttctact ttattgaagt aaatcctcgc gtacaagttg aacacacgat 1467421 aacagaaatg attactggtg tcgatattgt tcaaactcag atccttgttg cccaagggca 1467481 cagccttcac agcaaaaaag taaatattcc tgagcaaaag gacattttta caatcggcta 1467541 tgccattcag tcacgggtta cgactgagga tccgcaaaat gatttcatgc ctgatacagg 1467601 aaaaatcatg gcttaccgct caggcggcgg ttttggtgtc cgtcttgata ccggaaacag 1467661 cttccagggc gccgtgatca caccatacta tgattcactt ctcgttaagc tttcaacttg 1467721 ggctttaacg tttgaacagg cagctgccaa aatggtgcga aaccttcagg agtttagaat 1467781 cagaggcata aaaacgaaca ttccgttcct tgagaacgtt gcaaagcatg agaagttcct 1467841 gacagggcaa tatgatacat ctttcattga tacaacgcct gaattattta atttccctaa 1467901 acaaaaagac cgcggaacga aaatgctcac ttacatcggc aatgtgacag tgaacggctt 1467961 ccctggaatc gggaaaaaag aaaaaccggc gtttgacaaa ccgttaggcg taaaggtaga 1468021 cgttgatcag cagcctgcca gaggaacaaa gcaaattctc gatgaaaaag gtgcagaagg 1468081 gcttgcaaat tgggttaagg agcagaaatc tgtcctttta actgatacga cattcaggga 1468141 tgcccaccaa tcgttattgg caactagaat cagatcgcat gatttgaaaa aaatcgcaaa 1468201 tccgacggct gcgttatggc ctgaactatt cagtatggaa atgtggggag gcgcgacctt 1468261 cgatgtagcc taccgattcc tgaaagaaga tccgtggaaa cgtttggaag atcttcgcaa 1468321 agaagtgccg aataccttat tccagatgtt gcttcgctca tcaaatgcgg tcggctatac 1468381 gaattatccg gacaatgtga ttaaagaatt tgtgaagcaa tcagctcaat ccggtattga 1468441 tgtgtttcgt attttcgaca gcttaaactg ggtaaaaggg atgacgttag ccattgatgc 1468501 tgttagggat accggcaaag tggcagaagc tgcgatttgt tatacgggag atatccttga 1468561 caagaaccgg acgaagtacg accttgcata ttatacatcg atggcgaagg agcttgaggc 1468621 ggccggagcc catattctcg ggattaaaga tatggcaggg ctgttaaaac cgcaggctgc 1468681 atatgagctc gtttctgcgt tgaaagaaac gatcgacatt ccggttcacc ttcatacgca 1468741 tgatacgagc ggaaacggta tttatatgta tgcgaaagct gttgaagccg gcgttgatat 1468801 catagacgtg gcggtcagct caatggcggg attaacgtca cagcctagcg cgagcggatt 1468861 ttatcatgcg atggaaggca acgaccgccg tccggaaatg aatgtccaag gcgttgaatt 1468921 gctgtcccaa tattgggagt cggtgcgtaa atattatagt gaatttgaaa gcggaatgaa 1468981 gtctccgcat actgaaattt atgaacacga aatgccaggg ggccaataca gcaacctgca 1469041 gcagcaagcc aagggagtag gccttggcga ccgctggaac gaagtcaagg aaatgtacag 1469101 acgcgtgaac gatatgttcg gtgacatcgt caaggtaacg ccttcctcaa aagtagtcgg 1469161 agatatggca ctctacatgg tgcaaaacaa tctgactgaa aaagacgttt acgaaaaagg 1469221 tgaatcttta gatttccctg attctgtcgt ggagcttttt aaaggaaata tcggccagcc 1469281 tcatggcgga ttcccagaaa aactgcaaaa gctgatctta aaagggcagg agccgattac 1469341 agtcagaccg ggcgaactgc ttgagccggt gtcatttgaa gcgatcaaac aggaatttaa 1469401 agagcagcat aacttggaaa tttcagatca ggatgctgtg gcatatgccc tttatcctaa 1469461 agtcttcact gattatgtga aaacgacaga aagctatgga gacatctcgg tattagatac 1469521 accgacattc ttctacggta tgacattagg tgaagagata gaagttgaaa ttgagcgcgg 1469581 caaaacgctg atcgttaagc tgatttcaat cggtgagcct cagcctgatg ccacccgcgt 1469641 cgtttatttc gaactcaacg ggcagccgcg tgaagtagtc attaaagatg aaagcattaa 1469701 gtcttccgtt caggaaaggc tgaaagcaga ccggacaaat ccaagccaca tcgcagcttc 1469761 catgcctgga acagttatta aggtattggc tgaagcaggc acaaaagtca ataaaggtga 1469821 tcatttgatg attaatgaag cgatgaaaat ggaaacaacg gttcaggcgc ctttctcagg 1469881 aacaatcaag caggttcatg tgaaaaatgg tgagccgatc caaacgggag atctgctcct 1469941 tgaaattgaa aaagcataaa aaacaaagag tgtatatcaa tgatatacac tcttgttttt 1470001 tatatagaaa atgtggagtg aaacagatgg ttagaagaga tataagggga cttcagagat 1470061 tatagagtac tgtcacaagc ccaaaataaa aagaggctta tacagccaat attttagatg 1470121 ctttgtagta tgccgtgcat atttctttaa gcactatctg atttaaaagg ctttaatact 1470181 tatgttcgcg agctatagat ccatatgaaa tttctataat cacgatgaga aaggggacag 1470241 accgaagtga gccgctcact gatcatcaag ttcggcgaag gctggcgatt gaaacgcata 1470301 aagcgccaaa aaacaagaca taaaaaagac caaagccgcc taaggctttg gtcttgagtc 1470361 cttatgattg cctggattca taacggaaac gagcaatcaa taataagaag tagcatagaa 1470421 cgccaaacag acaggcaata aagaacgagt gggcaagtgc aaagcccaga gccagttcag 1470481 agtatacgat cataataccg gacagtgcct gtaatgtaat gaaaataaga catgagatcc 1470541 atccccaaaa gatctgtttt tgatctttat aggaagtaat agcatgaaca gcggcaacaa 1470601 taatccatac aaataaaagt aaggctgctg ctctgtggcc catttgcacc cattcatgga 1470661 attgggtcgg aagtccattg ttcagcgggc tgcacagcgg cacattagga catgccagac 1470721 ttgattcagt gtgtcttaca tatgcgcctg tatacacaac gatataggaa tatattaaaa 1470781 ttcctatcat gtgaaattgc atctttttgc cgatttgaag cggcttaacc agtgttctga 1470841 ctgatttatc agcttcaaat atgagcaatg ttaaaataag cactgaagca aaagaaatta 1470901 atgagatgcc gaagtgaagc gccataatca gcgcgttcga accgaatacg acagccaatg 1470961 cgccaagcaa tgcctgaaga aataaaaaga taattgacat gatcgcgaga aacgttgttt 1471021 cacgaaaaat cggcgtgatt tttctccatg accaaaacgc aaggcttagc acaaggataa 1471081 tagagattcc gcttgcgaat cggtggctcc attcaataat tgaagccgga ttcagttcag 1471141 ggaaaaaacg gccgtgacac agcggccact gtctgccgca tccttggccg gaacctgttt 1471201 ttgtaacgag ggcacccccg attaaaacaa ttagcatgac aaatgtcgtc agaacaccga 1471261 gagcttttaa tgctttattc atacaatatt caccttctta acatactgct gcaattttat 1471321 atacgttcca agtgtaagcg aatatgtgtt ttgtggcaat tcccagagcc ttttgttcac 1471381 aaaaatataa tagaatgacg gcttctggaa aatgtacact tgattattca tgccgggtct 1471441 gatagaaata aggtaaacgc aatgccgatt tggagattgc cttcatcttt ggtaaaattc 1471501 ataaaaagtt cacaaataaa ttcctgtttg tcgtttaata tttaatagga tgttttttta 1471561 caagatgtta tcttgtatga tagagttgca ggttatttta ttctcctgcg ttaggtttgt 1471621 aagggaggtt tacgttatgg ctaactccag aatcttaaat gatacagcta tagacggaca 1471681 aattgaagaa acaacggcat ggaaagattt tctgtccctt attaaaatag ggatcgtcaa 1471741 ttctaacctc atcacgactt tcactggaat gtggcttgca ctgcatatat ccggtttaag 1471801 ttttttaggc aatataaaca ccgttcttct tacgttaatc gggtcttcac tgattattgc 1471861 gggctcctgc gcgatcaata actggtatga ccgggacatt gaccatctta tggagcgtac 1471921 gaaagtaaga ccgacggtta cgggtaaaat tcagccgagt caggcgttat ggtctggaat 1471981 tttgctggtt gctttaggat tgatcatgct gctgatgaca actgtcatgg ctgctgttat 1472041 cggttttatc ggagtcttta cgtatgttgt attgtacaca atgtggacga aacgccgcta 1472101 tacgattaac acagtagtag gaagcgtttc cggtgcagtg ccgccgctta ttggatggac 1472161 ggcagtggaa gggaatatcg gtgtcgtagc atgggtgtta ttcatgattt tatttatttg 1472221 gcagattcct cacttcttag cattggctat taagaaaact gaggattaca gagctgcaaa 1472281 tattccgatg cttcctgtcg tatacggatt tgaagtgaca aaaagacaaa ttattgtgtg 1472341 ggttgcgtgc ctgatgccgc ttccgttttt ccttggtagc ctgggtcttc cgattgtcat 1472401 tctcggcttg ctgttaaata tcggctggct gattcttggc ttaatgggat tccgctccaa 1472461 gaatatcatg aagtgggcaa cgcagatgtt cgtttactcg cttaactaca tgacaatcta 1472521 tttcgttgcc atggttgtct tgacgctttt ctaaaaaata gatatgatgc ttgttttatc 1472581 gcttcaaaat aaacgatgac aactagtaaa tgccgccttg acctcttgtt taatcaggcg 1472641 gctttacttt tatacataga tggcattttg agtaaaaaaa ctcataattt aagagaagag 1472701 gaaatgtaag tgctttattg gtgataggtt ggatggcgat agatttcgat ccgctttccg 1472761 cctttgtatt gaccagaaaa ggggttgggt gaaatggtaa agcattggcg tcttatttta 1472821 ttattagcct tagtgccgct tctattaagc ggatgtggaa aacctttttt atccacgctc 1472881 aagcctgctg gcgaggtggc tgataaacag tatgacctga cagtgctcag cacattgatt 1472941 atggtggttg ttgttgcagt agtatctgtt atcttctttt atgtgattgt gagattcaga 1473001 agatcacggg tcggtgagaa cacgataccg aaacaggtag aggggaataa atttttagaa 1473061 atcacatgga ccgtgatccc gattttgctg ctcattattc ttgtgattcc tgttgtatta 1473121 tatacgctgg agctagcgga cacatcacca atggataaaa aaggccgcaa agctgaggat 1473181 gctcttgtag tcaatgttag ggcaaattta tactggtggg agtttgagta ccctgattac 1473241 ggcattatca caagccagga gctgattgta ccgacagatc agcgtgtata ttttaattta 1473301 aaagcctctg atgtaaaaca ttccttctgg attccttcag ttggaggaaa acttgatacg 1473361 aatacggata atgaaaataa gttcttcctg acatttgatt caaaacgaag caaagaggca 1473421 ggagatatgt tttttgggaa gtgtgcagag ctttgcggcc cttcacatgc gctgatggat 1473481 tttaaggtga agacgatgtc tgcaaaagaa tttcagggct ggacaaaaga aatgaagaac 1473541 tataagtcta cagcagagag cgatttggct aagcagggtg aagaactgtt taaagagaaa 1473601 aactgcctga gctgccatgc ggtagagccg aatgataagc gtgcagaagc cgctagaacg 1473661 gcacctaact tggcgacctt cggtgaaagg acaaaagtgg caggggtgaa agaggccaac 1473721 aaagaaaatg tgaaggcttg gctgaaggac cctgacagca taaagccggg gaacaaaatg 1473781 acaggcacat atccaaagct ctcagacagc gaaacaaatg cgctttatga atacttaaaa 1473841 ggcttaaaag cggaaagcaa gtagggaaga aagggagata ttgggggagg tcacatatgt 1473901 tgaatgcgct tacagaaaag cggacgcgcg gatctatgct ttgggattat ttgacgacgg 1473961 tggaccataa aaaaatcgca attctttatt tagtggcagg gggattcttc tttcttgtcg 1474021 ggggaattga agcgatgttt atcagaattc agcttgcaaa gccggaaaat gcgtttctca 1474081 gtgctcaagc gtacaatgaa gtaatgacta tgcacggaac gacgatgatc tttctggctg 1474141 cgatgccgct cttatttgcc ttgatgaatg cggttgtgcc tttgcagatc ggggctcggg 1474201 acgtttcgtt tccattttta aacgcgcttg gtttttggct cttctttttc gggggcattt 1474261 tcttaaatct aagctggttt ttgggcggag cgccagatgc gggctggaca tcatatgcct 1474321 cactttcgct tcattctaaa gggcacggca tagacttttt cgtcctcgga ctccaaatat 1474381 cggggctcgg gacgctgata gccgggatta actttttggc cacgattatc aacatgaggg 1474441 ctccgggcat gacgtatatg aggctgcctt tgtttacatg gacgacattt gtggcctcgg 1474501 cattgatttt gttcgcgttt ccgccgctta cggttggatt ggctctcatg atgctggatc 1474561 ggctgttcgg aaccaatttc tttaatccgg agcttggcgg aaatacggtc atttgggaac 1474621 atttattttg gatcttcggc cacccggagg tttatatcct aattttgcct gcattcggta 1474681 ttttttctga ggtcatccct gtgttcgcca gaaagcgttt gtttggctat tcttcaatgg 1474741 tttttgcaat cgtgctcatt ggctttctgg gctttatggt ttgggtgcac cacatgttca 1474801 cgactggtct cggcccgatt gcaaatgcga tttttgcggt tgcaacaatg gctatcgcga 1474861 ttccgaccgg gattaagatt tttaactggc tgttgacgat ttggggagga aatgtgaagt 1474921 atacaaccgc tatgctgtat gctgtctcat ttattccatc ctttgtgctc ggcggtgtga 1474981 cgggagtcat gctggcagct gctgcggctg attatcagtt tcatgatacg tattttgtgg 1475041 ttgcgcactt ccactacgtc attattggcg gcgttgtatt cggcctttta gccggtgttc 1475101 atttctggtg gccgaaaatg ttcggtaaaa ttctgcatga aacgatgggg aaaatttcat 1475161 ttgtattgtt ttttatcggc tttcacctca cgtttttcat tcagcatttt gtcggcttaa 1475221 tggggatgcc gcgccgggtt tatacgtttt tgccaggaca gggtctggaa accggcaact 1475281 tgatcagtac aatcggggcg ttttttatgg cggcagctgt tattcttctg ctggtcaatg 1475341 tcatatggac atcggtaaaa ggtgaatatg taggtgctga tccatggcat gacggacgta 1475401 cgctggaatg gaccgtttct tcaccgccgc cggagtataa ctttaaacag cttccttttg 1475461 tcagaggact tgatccgctt tggatcgaga agcaggcagg gcacaaatca atgacgccgg 1475521 cggaaccggt tgatgatatt catatgccaa acggctcaat cctgccgctc atcatttcct 1475581 tcggcctttt tgtcgcagcg ttcgggctgc tgtacagaag tgattacgct tggggcctgc 1475641 cggtgatctt tatcgggctc ggcatcacat ttattacgat gctgcttcgt tcagtaattg 1475701 atgatcacgg ctatcatatt cataaagagg aactgccgaa cgatgataaa ggggtgaagg 1475761 cataatgcaa gttcaagaaa aattcaccgc agaaaccttt ccagcttctc ctgaaaaagt 1475821 aaccctggaa gggaaaaata aatttttagg cttttggctt tttcttggcg gagagactgt 1475881 tctgtttgcg tctctcttcg ccacgtttct tgcgcttcgg aattcaaatg ccggtgatcc 1475941 gcctacgacg gaaatgttcg atgtgacact tgtattcatt gccacaatgc ttctattaac 1476001 gagcagttta acgagtgtgt acgcgatgta ccacatgaag aacttttcct tcggcaagat 1476061 gcagctttgg ctgggaatta cgattttatt gggggcgggc tttttaggac tggaaatcta 1476121 tgagttcaag cattacaccc atgaatttgg ctttaccatc acaagctctg cccttggttc 1476181 tgcgttttac acgcttgtcg gtacacacgg cgcccacgtg gcatttgggc ttatgtggat 1476241 cagcacgctt atgatccgca atgccaagag agggctgaat ctgtatacgg cgcctaagtt 1476301 ttacgttgcc agcctttatt ggcactttat tgatgtcgtg tgggtcttca tctttaccgt 1476361 tgtatattta atggggatgg tgggataaac atggtcgata aaaaaagcag agggcatatc 1476421 aatagcgacc ttgaatttaa gaaaaaaaag catgcccggg agatgaaata tcaagtcctg 1476481 tcttttggtt taatgatcgg tcttacgatt gttgcatttc tgactgtggc cacggacggt 1476541 gtcggcagct ggtttacgat tcctttcatt attttgctag ctgcaattca agtcattttt 1476601 cagctgtatt atttcatgca tatgaatcag aaagggcatg aggcgccggc actgtttttg 1476661 tattcagggg tgtttgtcgc gtttatcact gtgcttgcgt ttgtgacaat tatatggtgg 1476721 taatttgaac agccgccgga ggtgaagaaa tgaatcagtt ggagatattt gggtttcgcg 1476781 cgatgtggag cccttatctt ttttgtatcc tgttaggcat tacggcgctt tatctctatt 1476841 tttacaggcg aatgtcttca aagccgaatc gaataactgg taaagagatg gtgtgctttc 1476901 tgtcggcgat gctgttttta tatgcagccg agggaagccc ggttgatctg ctcggacata 1476961 ttatgttcag tgcgcatatg gtgcagatgg ccgtcctgta tttggttgtc ccgccgctgt 1477021 taatcgcggg gattcctgca tggctctggg aaaaaatcat tttcaggcct tcaatcaaac 1477081 cggttttttc cttttttacg acgcctttaa ttgctttgct tttgtttaac ggcatttttt 1477141 ctttatatca tgtaccgctt atatttgata ctgtcaaaac agatccgttt taccatacat 1477201 taatcacttg gcttatcttt gtgcttgcgt tcttcatgtg gtggccgctt gttcataagg 1477261 ttgagcgtct acggcagctc agcggcttga tgaagctggg ttatattatg gcggacggta 1477321 tgctgctcac acctgcttgc gccttgatca tgttcagcgg tgcaccgtta tacgccacct 1477381 atacagatcc ggctttatgg gctgaggcaa tgaggctttg cgtgccagcg gatatgatgg 1477441 ggcaggtccc attaacaggg ccagagatgt tgaatacact gcctttgtta gaggatcagc 1477501 agctcggagc agtcatgatg aaaatcattc aggaaattgt gtacggtact tttttggccg 1477561 ttattttttt ccaatgggtg aagaaagaaa gggaaaagga cgggcaggag gagccgccgt 1477621 atattcagca gacgatatca taaaaggtac agcgaaatat gctgtacctt ttcgttacat 1477681 ttgaactgtt tttaacatgt tggctatgtc ctgaatcagt gccttgcttt ttgtcacaac 1477741 ctgtacggga aactcttccg tttctccata ttctactcca tgagggtagt aatgctttcc 1477801 taggagaggg gacattaatt gaatcacggc gcgcccgctt ccgacatcgc cttctgccgc 1477861 aataccttgt atccgcaggt aaaacgtacc ctcaatcgtc gaaaacttct tgtcataggt 1477921 gactctctcg taatcccatt gacccgctct gataagacct ttgctttcca ttaagtcgtc 1477981 tagccagctg agctcagcct taaccccttc aagtccgctt tcagtaaact tcaacactga 1478041 cccctcctta taaaaattac ctttcctgac aatcatagta tgaaagcgtt aaactttcaa 1478101 tgaatcttct tcttttgaaa gtatgcaaaa attaaatttt gacgacaata gcactagact 1478161 aaaggaggtt aaacggatga caaaaataaa agatctgatg acagccgact tgcaatattg 1478221 cacggtatta gataatgtat atgaagctgc agtaaagatg aaggacgcaa atgtaggagc 1478281 gataccggta gttgatgagg acggggaaac attggtcggc atcgtaaccg accgcgatct 1478341 cgtattaaga ggaatcgcca tcaaaaaacc gaactcgcaa aaaatcactg acgcgatgac 1478401 tgaaaaacct gtcagtgtgg aggaagatgc ttcagtcgat gaggttcttc atttgatggc 1478461 atcgcatcag ctcagaagga taccagttac aaaaaataaa aaactgactg gaattgtcac 1478521 gcttggtgat ctttctttat ctgagcaaac gaatgaacgt gccggcagcg ccttatcgga 1478581 tatttccgaa ggggataata gagaagaagg cttttttcat taacacataa atctttgaca 1478641 tgttaaatag gctgtattgt aatgggatgt aaacaagaga ttgtgaatcg ccacgggggt 1478701 gatagattga aaaatatatt gagagcaatg gttatccttt tgattatctg cggaacctat 1478761 gttctgttta ttcaatatgg atctgttcct gaaaagaaat caaatgacag cgagcctcag 1478821 gtgtcgaatg aggaagcgca aagcggcaaa cgaatacata tgccgacttc agggttattg 1478881 tccttcatgg gcaagcacgc cgatgaagta acgaaaaagc ttggggaacc tgaacgtatt 1478941 gacccttcgg cttatgatta cgattggtgg gtatacaatc aaggtaagga tcaatatatc 1479001 caaatcgggg tattaaacaa taaagtggtc acattattcg cgtcgggtaa tgatattaac 1479061 gccaagcctt tcaaaattgg agaatcaact ggcgaagtat tcaagaccac ccaggtggca 1479121 ccatttgtga atgtagagta taaaggaaat tcctatcggt ttgaattttc tgaagaagat 1479181 atcaatacaa gaccgactgt aaaggtagga aagatgtatg tccagctgta tatggacaaa 1479241 tttgagggga agctatccag catcagggcg tttgatgcgc agacctttgt aaagcaaaga 1479301 ccttatgagg tagtgtaccg cggggaatta attaaaccga aagccgtttc agatgagaaa 1479361 tggaaaaaga tccaaacaac gagcgaaaag caaatccttg atttgacgaa tgtcatacgc 1479421 gttaaacatg gacttgcgaa gcttgagtgg gatcagccaa cggcggaagt ggcatttggg 1479481 catagtgagg atatgaagga aaataattat ttctcccatg tctctaaaaa atacggctcg 1479541 ctgaaagacc gcttagaaga agggcatgtt gattttcagc aagcgggaga aaatatcgca 1479601 tacaattatg tggacggtcc ggctgctgta gaaggctggc tgaatagcga aggccatcga 1479661 aaagcgcttc tgaattcaga ttatacgcat cttggtgtcg gagtagaccg gaaatattac 1479721 acccaaaact ttattaagcg atggtaatga aagccgcgga cgaatggttc ccggcttttt 1479781 ctatttccat acaagctggt ctgaatgaat gtgctgatag cttacagata aggccgtttc 1479841 ccatcccttc agtcaggctt tttcaccagt gtatagggat atcgctaaaa attcatttgg 1479901 gaatgaatat aggcgaacac aatgcccgac aaaacgatac attgtagtag gtaacgattt 1479961 tcggaggggg tgaggattgt ggcgaatcaa catgccaatc attcaatcaa tgactttaaa 1480021 caattcgtca aaaagcatcc caagctgata aaagaagtgc gcaaagaaca aagaagctgg 1480081 caggacgtat atgaaaattg ggtcctcttc ggggagagcg acccgatttg ggatccatat 1480141 cgggaaccgg aagaagcttc tgaagctgtg cctgaaacac cgcaaaaaaa tgattttgtc 1480201 tcgaaaatgg tgacagcggt gaaaaagatg gatgtcaatc aaatgaacga acaaatcaat 1480261 aaaatgagcc agtcgatctc atcgttgcaa agccttctta atacattttc cggaagcgga 1480321 cagaagcatt ctcagccagg ctctggacag catccttttt cttttcgaaa ggattaaaaa 1480381 aggggagctc atatgcgcaa agaggttcag gaatatattt tagcaaacga agaacggaaa 1480441 cgattcatca gagaacagcc gatatggtac cgcaggcttt caagaaaacc ggatgatctg 1480501 tcctcctttc agcttgaaat gatgaatttt tatgaaaaaa ccattccgca tcgggtgaat 1480561 cagtttacga acgggattca aatggcgcaa atgatgatgc aaatgtttca agcgatgcgg 1480621 acaaaagatt aaaaggcccc gaagaagggt cttttttcat gcggtcataa ggttttgttg 1480681 gcggctgcgg ttaagcattt tccaattggc tggtttcatg gtaaactaac aactggaggt 1480741 gcatgttatg tatgcgacga tggaatccgt gcggcttcaa agtgaagctc agcagcttgc 1480801 cgagatgatt ctgcagtcgg agacggctga gaactaccgc aattgttaca agcgtctcca 1480861 ggaagatgaa gaggcaggtc ggattattcg ttcttttatc aaaataaaag agcagtatga 1480921 ggatgtacag cgttttggca aatatcatcc tgactataga gaaatatccc ggaaaatgag 1480981 ggagatcaaa cgtgagctgg acctgaacga taaggtggct gacttcaaga gagctgaaaa 1481041 tgagctccag tccattcttg atgaggtcag cgttgagatt gggacagctg tttcggagca 1481101 tgtgaaagtt ccgactggga acccttattt tgacggtttg tcttcatgcg gaggcggctg 1481161 cggttcaggc ggaagctgcg gatgtaaagt gtcctgacga gactggccgt ctcgtctttt 1481221 acatataaga gaaaacaggc aggtgattgt attggagaat aggcgccagg gcatggttgt 1481281 gtatctgcac tccctaaagc agagcaaaat gctgaggaag ttcgggaatg tgcactatgt 1481341 atcaaaacga ttaaaatatg tcgtactgta ctgtgatatg gaccaaattg aaaaaacaat 1481401 ggacaagatt gcgtcttact catttgtgaa aaaagtggag ccttcttata aaccgttttt 1481461 aaaattggaa ttcgagtcaa agcttgataa ggcaaaagaa tacgattata aaatcggcat 1481521 atagctataa aaaaatcccc gcaggcatct gcggggtcct tctattcctt aatatgttaa 1481581 ggagaaggca aagggagagg agaaaccgga ggaagaactt atggggaaac gtaagtcttc 1481641 tccgcggttg gcaacaacat cctctagatg ctgttgctta tagtatggac aaggatcatg 1481701 ctgcctatac acctgtttat caagattagc gttcattgtt tggaagaatg ctttatgtta 1481761 agataggatt gatttttttc tatgtacata gcggcgtccg gccgaataaa gaaacaaaat 1481821 agcttttaga aaaagtggtg tggaacatga gagtaatttc tggatcaaaa aaaggccgtt 1481881 cactaaaggc tgtagccgga acatcaacaa gaccgacaac cgacaaagtg aaggaatcca 1481941 ttttcaatat gatcggccct tattttgacg ggggcagggg acttgactta ttcgcaggga 1482001 gcggaggtct tggaatcgaa gcgctttcac gcgggtttga gcattgtata ttcgttgacc 1482061 gtgattttaa agcgattcaa acggtaaaat ctaatttgaa aacgctggag cttacaaaac 1482121 atgcacaggt ataccgcaat gatgcggaac gtgctttgca cgctgctgct aaaagagaaa 1482181 ccggctttcg cggaattttt ctcgatccgc cgtataagga acaaaagctg aaagcacttt 1482241 taactttgat tgacgaatat caaatgctgg aagaagacgg ctttatcgtc gctgagcatg 1482301 acagagaggt cgagcttccc gaaaccgtag gagatcttgt gatgacaaga aaagaaacct 1482361 atgggttaac aggtgtagcg atttataaaa agagggggta gtgaggtggc gagtatagct 1482421 gtctgtcccg gcagttttga tcctgtgacc tacgggcatc tggacatcat caaacgcggg 1482481 gcgcatattt ttgaacaagt gtatgtatgt gtgctgaata attcttcaaa aaagcctttg 1482541 ttcagtgtgg aagaacggtg tgagcttctg agagaagtca caaaagacat tccgaacata 1482601 acagttgaaa catcgcaagg cctgttaatt gattatgcaa aaagaaaaaa tgcgaaagcg 1482661 attttaagag gcttgagagc tgtatctgat tttgaatacg agatgcaggg gacatcagta 1482721 aaccgggtgc ttgatgaatc tattgagacg ttttttatga tgacaaacaa tcaatattcg 1482781 tttctaagtt caagcatcgt aaaagaagtg gcaagataca acggctcggt atcagagttt 1482841 gtaccgccgg aagtagagtt ggcgcttcag caaaaattca gacaaggatg agggttttga 1482901 ctcatccttt ttttgttccg tttgtcagtc tgtaagaaaa aatgataatg tacgtaaaca 1482961 gcgcgcatag tgtgacagca ggtccgatct gcacaagcag attccagccg tttataaagg 1483021 cagttgacat gtcactgctg ttaagagatt taaatacata ctgatacgga tcatgccatg 1483081 ctgtgtaaag aggtttccat aaaagcatga cgaagacagc ggcataaacg ccctgcagca 1483141 aacgtgcgat aaagaatggt ttaaatctaa tgtcggtttc cgataaaata cctgccacct 1483201 gagcttgtac ggaaaagccg ctaaacccaa gaataaagct gacgataatg gctttttgca 1483261 gaagagaaac atctgtctcg ctgacaagct tgctgcctaa tgtaatttca aacatccctg 1483321 ataaaagcgg aatgtccaat tgagtcggaa gctgaaacaa agtcagtgct ccttttgtga 1483381 aaacagacaa aacatcagtc agctggacca ctgacaacag ccgattgaag acagaaaata 1483441 aaataataaa gccgcctacc ataagaagcg tttgaacaga agacgtcacg gcgtcgccta 1483501 aaattttacc taagggccgt ttttctgcaa gtctggcggt atgaagagcg tgtaaagcat 1483561 ctttgactga agggaaaggt atcgttttct ttcttctgag atgctgctct tccttgcggc 1483621 cataggagcg cattgttaaa ccgacggcaa gattccccaa atagtgtgca gaagctaata 1483681 aaatgcctag tgatgcgttt tgaaagaaac cgacggcaac agcgccgaaa ataaagagcg 1483741 ggtttgaaga attggtaaac gacgcgagcc gttctgcctc tactcttgaa atctgatttt 1483801 cctgccgcag acgggcagtg agttttgcgc ccgctgggtt tcctgatgcc attcccatag 1483861 caagaacgaa gccgccgaca cccggcacgc gaaagatcgg ccgcataaaa ggctcaagca 1483921 aaacaccgac aaaccgcaca atgccaaagc cgattaagag ttcggacaga ataaaaaatg 1483981 gcagcaatga cggaaacaca acctcccacc acatagacag cccggtttta gaggcttcga 1484041 atgaggcctg tggatgtgag atgacagtcg ctgttaaaaa aagaaaaaac gaggcaatca 1484101 aaagtgtatt aatcttcgac aagttcattc ttacctcccc gatgctaaaa atgcccaatg 1484161 acatgtatat catgataaaa taatgtatga tgtaaaacgg ccaagcagta cctgtcctct 1484221 tgattctttg tactaatata cgagcatagg ggttcagttt agaccataga attcggtata 1484281 cagggaattc aggcaggagg ttaacgcttt ggccaaacct aaaatcgggt tagcgttagg 1484341 atcgggaggg gccagagggc ttgctcatct cggtgtgctt tccagtttac ataagcacca 1484401 aattgaagtg gatatgattg caggaagcag catgggcgct ttggtgggca gtttttacgc 1484461 cgccggacat gacgtggcaa cgatgaaaaa agtagccaaa gcctttaaac gaaggcttta 1484521 tgctgattat acggtgccga aactcggttt tttaaaaggt gaccgcgtca gacagcttgt 1484581 gcatgcttat acattcggaa aaccgattga agagctccaa atcccgctgg gcattgttgc 1484641 gtgtgatcta cagacgggag aaaagattgt gttccgaaaa ggatcagtgt cagatgcagt 1484701 gagggccagc atcagcatcc cgggtatctt tattccgcag cggctggacg gacgccttct 1484761 tgtagacggc gcggtcgtcg atcgaattcc ggtttctgtt gtgaaagaca tgggagctga 1484821 tattatcatc gcttcggatg tttccagggt tcgaaaaact gaaacagcag tgcatatttt 1484881 tgatgtgatt atgcaaagta tggatatact gcaaaatgaa ttagtgcggc atcaaacaat 1484941 tgccgcagat atcatgattc gcccttccct tgaaacatac agctcaagct cgtttgccaa 1485001 tattgaagaa atgatatcgg caggcgaaga ggcgacaaac cgaatgatca gcaagataag 1485061 aaaagaaata gagaattggg agggctcata atttgctacg taaaaaacat tttagctgga 1485121 tgctcgtcat cctcatactg atcgccgttt tatcatttat aaaacttcca tactatatta 1485181 caaaaccggg agaagcgaca gagcttgctt cattgataaa agtggaggga ggctacccgg 1485241 aaaaaggaag tctgtcctta atgactgtta aagtgggacc ggctaatcca tttacatatg 1485301 tgtgggcaaa gatgcaccct tattatgaaa ttgttcctga tgagagcatt aaggaggaag 1485361 gcgaatcaga taaggagtat atgaaaagac agctccaaat gatgaaaagc tcgcaagaaa 1485421 atgcggttat agccgcctat caaaaggcag gaaaaaaagt cagctattcc tttaacggca 1485481 tatacgcaag ctcagttgta gaaaacatgc cggcaaaagg gaaaatagaa gtcggtgata 1485541 aaatcatcag cgcagacggc aaaaactatc agtctgctga aaagctgatt gattatatca 1485601 gcagcaaaaa agcgggagat aaagtcacgt taaagatcga aagagaagaa aaagaaaagc 1485661 gtgtcaccct tacgttaaaa caatttcctg atgagccgga tcgggcagga atcggagttt 1485721 cgctttatac agacagaaac gtgaaggtag agcctgatat tgattttgaa atcgaaaata 1485781 ttggcggccc gtcagcaggg ttaatgatgt cccttgaaat ctataatcag ctgacaaaac 1485841 cagacgaaac aaaaggctac gatattgcgg gaacaggtac gattgatgtt gacggaaaag 1485901 taggcccgat cggcggcatt gatcaaaaag tcgtcgccgc agacaaagcc ggaaaagaca 1485961 ttttcttcgc gccaaatcaa aacggcgcca gcaattccga ttataagaac gcagtaaaaa 1486021 cagcaaaaga tattgattca aatatgaaga ttgtgcctgt tgataccatg caggatgcga 1486081 ttgattattt gaataagctg aaagcgaaaa gcacctgatt ctcaggtgct ttttctatac 1486141 atttaaaaag tgttgttcat cttcgtcata tcgaatcggt gcatgtccgt attcctgtag 1486201 gtcaaactca gttctcagcg gctcttctat cggcaggctg taaatcctgc ttgcttttac 1486261 gtccagatcg agagctggat gggagaaaga ggacagtttg ctgacaagcg gaacagacag 1486321 tgcttttttc ttttcggata aataagcctg tccttttttc gtcatgccga gaagcctgat 1486381 atacggcgcc ttatcgttgt caagcagctt ttgcatatcc tgtttttttg ttctggttaa 1486441 aatgtgtgta ttcatccgct ggagccttgt ccacgtatag cgttttgttt tcagcagttc 1486501 cataaattcc tgataggagc tggattttct gatcgaacga ataattctgt gctctaaacc 1486561 ttcctccacc tcgtatactt gctgtaattc ccgtgccgtt acagttgaaa ggctgtattt 1486621 taagtaagaa aagtagcttt caggtgtatg ccacaatccg aaagatttgc ggtaagctgc 1486681 taattcacgt gcagatgcag cagggagaaa acgaaggcag gcttcgagat tctggccaat 1486741 catcgctttt ctaatgcttg tggcacttgc tatatggttt tcgccttcag ggagatcggc 1486801 atcatgatag tccgaagaga ttcgtgccgt agtataaggt ttcataggat atcccccggt 1486861 tagaatcgag gtcacatact ggtatcccaa aatgttattt ggttttgaca agtcaagtgc 1486921 actttcagta tgcaaaatgg agctgaaggc gatagccgcc gctgctgggt aactggcccc 1486981 ctttttaagt tcttctttaa ttcggtcatt caatatatgt ttatgctcat caataagctg 1487041 tgctgtttct aaaaaaggct tgatatcccc attttcactc ccgaaaaaca gcgcctcaca 1487101 ttcaagttcg ttcaggatgg aaacactgcc gcgtgcaaaa atgtctgctt tttgcacggc 1487161 ataaagataa ggcagctcaa tgacaagatc aactccgctt tgcagcgcca tttttgttcg 1487221 ggcccatttt gatacaacag cgggttcccc gcgctgtaaa aaatgtccgc tcatgaccgc 1487281 gacagccgtg tcacatccgg tttgcagctt tgctgtttgg gcatgataaa ggtgaccgtt 1487341 atgaaaggga ttatattcaa ccaccaatcc gacagctttc atattttttc cgcctttctt 1487401 gctatgttta aaaacgtatg gtacatttgc aaatgaaaac tcttacgcct tatttttgtt 1487461 ttaagtgtat gcatagcata ttccgctgtc aacgatactt caatggcagc attatgctgt 1487521 aaagaaaaaa tattgacaaa aacaatctta aaagctataa tcatgtttgt tgctttcctg 1487581 aggtgataca aatgaaatgg acgatttatc agctgcatca aatgccaaaa caaagttttg 1487641 agtttgatga aacagttgag ttaaatgagc tgacaaagct gaattctgac attcgccgca 1487701 tttctcccgt tcgggtgaag ggcagagcgg atatcaaatc caaacaggtt tcgtttgatt 1487761 ttacaatttc aggcgaaatg cttttgccat gctcaagaac actcgttgat gttccgtatc 1487821 catttgaaat ttcaacaaaa gaactgttta tatttcatca cacggatgat atagaagatg 1487881 atgacgttca cattgttgag gacgatacta tcgacataac tccgatcgtg aaagaagaaa 1487941 ttcttttaga aatccctatg caaatctttt gtgaatctga acaagaaaaa ggagctgctc 1488001 ctcaagaagg aaaggattgg caagtcattt cggaagaaga caagaagaat caagttgatc 1488061 cgagacttgc agcccttgaa aagctcttaa aacaagatga tgaatcttaa ctctttaagg 1488121 aggtgggaat aatggctgta ccttttagaa gaacttctaa aatgaagaaa agattgcgcc 1488181 gtacacattt caaacttaat gtacctggta tgacagaatg tccgtcatgc ggagagatga 1488241 agttgtctca ccgtgtatgc aaagcatgcg gatcatacaa cggcaaagac ataaatgtaa 1488301 aaagtaacta atgagaaaag cgcagggtga aagccctgcg ctttttcttt ttctcttcct 1488361 gtcagcttgc ggaaaatttg tgagtgcaaa tagtctatct aatctattac cggcatatgt 1488421 atgagataaa taagctgaca tggagggaga ttgaatttga ccattacaag acaagatgct 1488481 tggactcagg atgaggattt gctgctggca gaagtggtgc ttcgtcatat tcgagaggga 1488541 ggaacacagc tttcagcctt tgaggaggtt ggaagggcgc tgaccagaac cgcggcagcc 1488601 tgtggtttca ggtggaactc gtatgtgaga aaacaatacc agtcaggtat agagcttgca 1488661 aaaaagcaaa ggaaagaact gagaaagcaa atcggcgttc attcggtcaa tatgccgaat 1488721 tccatgaagc agactgcctc ggcatcgtca gaaggaaaac gagatttgtc cattcaggat 1488781 gtcattcaat ttctcgaaca attcaaagaa acaccgtctg cacaagaatt tcagcttgaa 1488841 agggaaaaat tgaaggagca aatccaatcg ctgcaaaaag agcttgagga tttgcggagt 1488901 gaaaatcaga cattgcggaa tcagctagag atgacagaag aggattacaa ggcactgatc 1488961 gatatcatgg atcgggccag aaaaatggtt gtttcgaagg aagacggaag aatgaaaaaa 1489021 gcggctcaag aaacgtaaag aaacgcctga aatgaaccgg ccctatagta agaataggcc 1489081 ggttgttttg atttctatgc agactctccc ggtgtcattt cgcgatccat atcaggatgc 1489141 cagatgagcg ggttttcccc tttgtcccgc gccatatcat acttaacagt tttaaagttc 1489201 attttgttcc aaaattccgc tgatttcatt ctcggatttg tccggatcgg cattttgaat 1489261 gattttgcaa attcaaccaa ggctctcccg tatcccctgt tctggtagcc cggaagaacc 1489321 tcaagcttcc acagctccaa ataatcctgg cggttgtcaa aatagggatt cgatttgccg 1489381 ttaacttgat acagactcat tcgtgctaca agtttatcgc caaaataaat cccgtaaaaa 1489441 ggcgaggtgc tgtcattttc aataatatta tcctgaagtt cttcaagcat tgaaagctcc 1489501 tgaatgccgt attctttgaa tttcttgaat tcttccagcg ttttatagtt gataagcaga 1489561 cgttctacct ttgtcaaaca aatctccccc tttgttgttt ctacatatat tgtaaacgct 1489621 ttatttaaaa aatccaaata tttaaacttt aattttaagc acatgggatc tttgagaagt 1489681 aatttcttct tacttctgct atgataatac gtaaatgcta aattgggtgt gacatcatga 1489741 aaattggaat tatcggcgga ggctccgttg gtcttttatg cgcctattat ttgtcacttt 1489801 atcacgacgt gactgttgtg acgaggcggc aagaacaggc tgcggccatt cagtctgaag 1489861 gaatccggct ttataaaggc ggggaggaat tcagggctga ttgcagtgcg gacacgagta 1489921 tcaattcgga ctttgacctg cttgtcgtga cagtgaagca gcatcagctt caatctgttt 1489981 tttcgtcgct tgaacgaatc gggaagacga atatattatt tttgcaaaac ggcatggggc 1490041 atatccacga cctaaaagac tggcacgttg gccattccat ttatgttgga atcgttgagc 1490101 acggagctgt aagaaaatcg gatacagctg ttgatcatac aggcctaggt gcgataaaat 1490161 ggagcgcgtt cgacgatgct gaaccagacc ggctgaacat cttgtttcag cataaccatt 1490221 cggattttcc gatttattat gagacggatt ggtaccgtct gctgacgggc aagctgattg 1490281 taaatgcgtg tattaatcct ttaactgcgt tattgcaagt gaaaaatgga gaactgctga 1490341 caacgccagc ttatctggct tttatgaagc tggtatttca ggaggcatgc cgcattttaa 1490401 aacttgaaaa tgaagaaaag gcttgggagc gggttcaggc cgtttgtggg caaacgaaag 1490461 agaatcgttc atcaatgctg gttgacgtca ttggaggccg gcagacggaa gctgacgcca 1490521 ttatcggata cttattgaag gaagcaagtc ttcaaggtct tgatgccgtc cacctagagt 1490581 ttttatatgg cagcatcaaa gcattggagc gaaatacaaa caaagtcttt tgagcttttt 1490641 cggtaacatg ctatactcat ttcggatcac taactattta ttggagaaag gaagttctag 1490701 aagatgcagc taactgaact ttccatcaaa aatcagaatg tgtttgtaca gcactatata 1490761 gatggcaaag aagaaatgtc ttcttttttt gattacagta ttcatcataa ggacatgtgg 1490821 cgcgaaagac tggaagactt atcttcccgg tttttcgcaa gagaggaatt ggcggcgtac 1490881 ttaacctctt accataataa attcggttca agtgcgatgc agtctgctat tgagaagctg 1490941 aaggacccgt caagtgccgc tgtagtcggc ggacagcagg caggactttt aacaggaccg 1491001 ctttacacca tacataaaat catttcaatc attgttttag caaagcaaca agaaaaggaa 1491061 ctgcaagtgc ctgtcatacc aatcttctgg gtggctggag aagaccacga tttggatgag 1491121 attaattttg ttcacacatc tgaagagaat gggcctgtga aaaaaaagct gcctcagtct 1491181 tattggaaga aatcatcagc agcgagtaca tcgcttgatc aggaaaagtg tgccgcgtgg 1491241 atagatgatg tttttgccgc ttttgaagaa acagaccata cgaatacact tctcgacaat 1491301 gtgaaacgat gtttaaggga atctgttacg tttactgact tctttgaact gctgatcgcg 1491361 gatttgttcc aagaagaggg cttagtttta ttaaattctg gggatccggg gattaaaaag 1491421 ctggaaacgg ccatgttcca aaagattctt cgagaaaatg atgaactcgc ccgggctgta 1491481 tcagatcagc aggccttcat gcgtcaagca ggctacaaac cgattatcga gtccggaaaa 1491541 gagcaggcga atctgtttta tgaatacgaa gatgagcgtt ttttaattga aaaagataac 1491601 ggccgatttg tcatcaaaga gcttgatcta ggatggacga gggatgaact tcatacacat 1491661 atggaagaac atccagagcg tttcagcaac aatgttgtaa cgagaccgtt aatgcaggaa 1491721 tttctcattc cgactttagc atttattgca gggcctgggg aaatcaatta ttggggcgag 1491781 ctcaaacagg catttgcggt gatgggcttc aaaatgcctc ctgtcatgcc aaggctgaac 1491841 attacgatac ttgagcggca tattgagaaa aaactggctg aacggaatat ctcattacaa 1491901 gacgcgattg agcgcggaac ggagaatcaa agagagacat acttcgagcg ccagattccg 1491961 gaagagttta cggcggtgat ggatcaggcg aaaagccaaa ttgaagcgat tcacaaaacg 1492021 gtccggcagg aggcgttaaa ggttgatcaa agcttggaac ctttacttct gaaaaatgcc 1492081 gcttttattc aggatcagct tcaattctta gagcgcacgg tgatgaagcg aattgaagaa 1492141 aaagaaggct acgtcttgaa ggattatgaa agaattcaaa atagcattaa gccgcttctt 1492201 gcgccgcaag aacggatttg gaatatcatg tattatttga acaggtacgg tccaaaattc 1492261 ttcacgacat tcaagaatct gccattttct tttcaaaatc aacatcaagt tgtcaaactt 1492321 tgaaataaag ttttaaagaa ccctgactag ttcagggttt ttttttatgg gtaaacagtg 1492381 taaaatgaag ttgtggagcg aagtggtgaa tagtggtgag ttaaggagag aaagtggggc 1492441 aagagatcat gtttatgggt gaatatcagc ataccatcga tgcgaaaggc cgcatgatcg 1492501 tacccgctaa attcagagaa ggcctaggtg agcaatttgt gctgactaga ggacttgacc 1492561 aatgtctctt cggctaccct atgcacgaat ggaaacaaat tgaagaaaaa ctaaaagctc 1492621 ttcctctcac aaagaaagat gcccgcgcgt ttacccgttt cttcttttca ggggcgactg 1492681 aatgcgaact ggataagcaa ggcagggtaa atatcgcatc atctctattg aattacgcca 1492741 aactggaaaa agaatgtgtt gttatcgggg tttctaatcg aattgaattg tggagtaaag 1492801 taatttggga acaatacaca gaagagcaag aagattcatt tgctgaaatt gctgaaaaca 1492861 tgattgggtt tgatatataa tgattcttcg tgtataacac tctaaaaaca atttcaattc 1492921 atcctgataa aaggtgggac caacacaata tgtttcaaca caagacagta cttcttcgtg 1492981 aaaccgtaga cggacttaat attaaaccag acggtacata tgtagactgc acactcggcg 1493041 gagctgggca tagtacatac ttattgcagc agttatccga gaaggggcgt ttaatcgctt 1493101 ttgaccaaga tgatacggca ttacagcatg ctaaagaagt gttgtccgat tataaaggac 1493161 agctcattct gattaaaagc aatttcaggt atttaaaaga atatttgaat gaacaaggcg 1493221 ttacagaagt agacggcatt ttatttgatt taggggtgtc ctctccgcag ctggatacac 1493281 cggagcgcgg attcagttac catcatgacg caccgttgga catgaggatg gaccagtcgg 1493341 ctacgctttc ggcgaaagaa gtcgttaatg agtggcgcta tgaggatctc gtccgtattt 1493401 tctttaaata cggagaagag aagttcagta aacagatcgc cagaaaaatt gaggaggcaa 1493461 gaatgaagtc tcctattcaa actacgggcc aactggtcga tctaataaaa gacgcgattc 1493521 ccgctccagc gagaaggagc gggggacatc ccgctaaacg cgtgtttcag gcaatcagaa 1493581 ttgccgtaaa cgatgaactt agggtgtttg aagaagcttt ggagcaggca attgaggttc 1493641 tgaagccagg gggcagggta tcggtcatta ccttccactc gctagaagac agaatttgca 1493701 aaaccacttt taaagaaaag tcgtcgcttc cggaacttcc tccgggactt cctgttatac 1493761 cggaagagtt tgaaccggag ctgaagctca tcacacgaaa accgattacg gcatctcaag 1493821 aagagcttga agagaacaac cgggctcgtt ctgccaagct tcggattgct gaaaaaagaa 1493881 aataacgaaa cgcgaacgca aaattaaaag gaggtcatca gcctatgagc aatttagctt 1493941 accaaccaga gaaacagcag cggcatgcga tcagtcctga gaaaaaagtg attgtcaaga 1494001 aaagggcttc cattactctc ggagaaaaag tgcttcttgt cctctttgct gcggcggtgc 1494061 tcagcgtatc gcttttgatc gtatcgaagg cgtatgcggc atatcaaacc aatattgagg 1494121 tgcaaaagct tgaggagcaa atttcatccg aaaataagca aattggtgac ctcgaaaaaa 1494181 gcgttgctga tttaagcaaa ccgcagcgca ttatggacat tgcgaaaaag aacggcttga 1494241 atttaaaaga taaaaaagtg aaaaacatac aggaatgatt caaatgccaa aaaagaataa 1494301 atttatgaat agaggagcag cgattctaag tatttgtttc gctctctttt tctttgtcat 1494361 cctggggaga atggcatata ttcaaataac cggaaaagcg aacggcgaag tgcttgcgac 1494421 aaaagcgaca gagcagcatg aaaagaaacg gaccatcgaa gcgagccgcg gctcgatttt 1494481 agaccgaaaa ggaaaagtca ttgcagagga cacagcgacg tataaactga ttgcgattct 1494541 cgataaaaaa atgaccactg atgtcaagca tcctcagcat gttgtaaaca aagaaaaaac 1494601 ggcggaagca ttgtctaaag tgataaactt ggacaaggcc gacatccttg atatcttaaa 1494661 taaagatgca aaacaagtcg agtttggctc agctggccgg gatattacgt attcacaaaa 1494721 gcaaaaaatc gaaaaaatga aactcccggg catttcattt ttacgggata caaaacgcta 1494781 ctatccaaac ggagtatttg catctaatct aatcggctat gccgaggttg atgaagaaac 1494841 aaatgaaatt tccggcgcga tgggattaga aaaagtgctg gataagtatt tgaaggagcg 1494901 ggacggatat gtgacatatg aaagcgacaa atccggctgg gagctcccga acagcaaaaa 1494961 taaaattaca gcgccaaaaa atggtgacaa tgtatattta accattgacc agaaaattca 1495021 aacctttttg gaagacagca tgacaaaagt ggcgcaaaag tataatccga aaaaaatcat 1495081 ggccgcagtc gttgatccga aaacgggcaa agtccttgcc atgggacagc gcccaagctt 1495141 tgatccgaac aagcgcgatg tgacaaacta ctataatgat ttgatttcat atgcgtatga 1495201 acccgggtcc acgatgaaga tctttacact cgctgctgcg atgcaggaaa acgtgtttaa 1495261 tgcgaacgaa aaatataaat cagggacatt tgaagttggc ggagcacctg ttaaggatca 1495321 caataacggt gtaggctggg gtccgacaac atatcatgac ggcgtcctaa ggtcgtcgaa 1495381 tgtcgctttt gcgaaactgg cgaaagaaaa gctgggatat gaccgcctca atcaatattt 1495441 gcacaaattc aatttttacc agaaaacagg tattgatttg ccaggagaag tctccagcaa 1495501 aatcaacttt aaatatgaat ttgataaggc gtcaactgca tatggccaag cgtctgcggt 1495561 cacaccaatt cagcagattc aggccgcaac ggcaattgca aatgacggta aaatgatgaa 1495621 accttatgtc attgaccata tcgttgaccc tgataaagat aaaactattt atcaaaataa 1495681 gccggaatca gccggaactc caatttctgc aagtactgcg aaaaaggtgc gggatatatt 1495741 aggagaagtc gttacatcga agatcggaac agggcaagct tataaaatcg aaggttttga 1495801 tgttgccggg aaaacaggta ctgcgcaaat agccggtaaa ggcggatatt tagacggcac 1495861 agataactat atcttttcgt ttatgggtat ggcgccaaaa gatgatcctg agcttttaat 1495921 ttatgttgct gtacagcagc cgcaactaaa agcaggacaa agcagttcag atccagtatc 1495981 agaaatcttc aatccaacaa tgaaaaatag cctgcactac ctaaacatcg aaccaactga 1496041 aaaatctgac tcagataagg aagaaacaaa agcgcagaca atgcctgatt taacagatca 1496101 aacggtagct gctgctcaaa agaaagcaaa agaggagaat ctcacaccaa ttgtcatcgg 1496161 cagtgatgtc gctgtaaaag aacagtatcc gaaagcggat gaggaagttc tcaccaatca 1496221 aaaggtcttc ctgaaaacgg gcggcaaaat caaaatgcct gatatgacag gctggtcgag 1496281 aagagaggtt ctgcagtacg gcgagctcgc gggaattcat attgaagtaa gcggacaagg 1496341 ctacgctgtc agccaaagtg ttaagaaaga caaagaaatc aaagacaaaa ccgtaatcaa 1496401 ggttaagttt aaaaatcctg attaaaaaga aagccgtcgt tatgcaggct ttcttttttt 1496461 atgccttcag aggagcatcg ttctacctgt ccaaattcag gcataaaatg aaacaagcct 1496521 aaataaggag tgaacggtct cttgcgcgtc tcgaatgtaa cggttagaaa acgtttatta 1496581 tttgttttgc tttttggcgt gatcgtgttt ctgatcattg atacaaggct ggggtatgtt 1496641 cagtttgtga tgggcgaaaa actgacttcg ctagcgaaag attcctggag ccggaacttg 1496701 ccgtttgagc cggagagagg cgagattctg gatcggaatg gtgtgaagct cgcaacaaat 1496761 aaaagtgcgc cgaccgtatt cgtcgtgccg cgccaagttc agaatccgat gaaaacgagc 1496821 aagcagcttg cggcggtgct caatatgtca gaagaaaaag tatataaaca tgtgacaaaa 1496881 aaagcgtcaa tcgaaaagat cactcctgaa gggagaaaaa tttcaaatga gaaggcgaaa 1496941 gaaatcaaag cgcttgattt aaaaggtgtg tatgttgcgg aggacagtat ccgtcattac 1497001 ccgttcggca gctttttatc tcatgtgctt ggatttgcag gaattgacaa ccaagggctc 1497061 cttggacttg aagcctatta cgacgatgat ttaaaagggg aaaaaggttc tgttaagttt 1497121 tatacagatg ccaaggggaa gaagatgcct gatgaagcgg atgactatac gccgcctaag 1497181 gatgggcttg atatgaagct gacagttgat tcaaaggttc agacgataat ggaaagagag 1497241 cttgataacg ctgaggccaa atatcatccg gacggcatga ttgccgtagc catgaatccg 1497301 aaaaacggag aaattttggg gatgtctagc aggcctgact tcgaccctgc tgattaccaa 1497361 tctgttgatc cgtccgtcta caatcgaaat ctgccagtat ggagcacgta tgaaccggga 1497421 tctaccttta aaattattac acttgcagca gcccttgaag agcaaaaagt aaatttgaaa 1497481 cgggatcaat tttatgataa agggcatgct gaagtggacg gagcgagact gcggtgctgg 1497541 aaaagaggcg ggcacgggct gcagacgtat ctggaagttg tgcagaactc ctgcaacccg 1497601 gggtttgttg aattaggcga gcgcttagga aaggaaaagc ttttcaaata tatcaaagac 1497661 tttggttttg gacaaaaaac ggggattgat ctccaaggcg agggaacagg catcttattc 1497721 ccgcttgaga gagtgggccc ggtggagcaa gcaactacgg ctttcggaca gggagtatcc 1497781 gtcacgccga ttcagcaggt tgcagcagta tccgccgctg taaacggagg aacgctctat 1497841 acaccttata ttgcaaagga atggatcgat cctgttacga agaaaacggt caaaaaacaa 1497901 tcaccaatcg caaagaaaca agtcatttct gaggaaacat ccaaacaaat ccgctatgct 1497961 ctagaaagcg tcgtcgcaga aggaaccggc cgcaatgcat ttgtagaagg atatcgtgtc 1498021 ggaggaaaaa cgggaactgc acaaaaggtt aaagatggaa aatatcttga aaacaaccat 1498081 attgtatcat ttatcggttt cgcgccagca gatgatccga gtctagtcgt ctacgttgcg 1498141 gtggataacc cgaaaggcac gattcagttt ggcggaacgg tggcagcgcc tattgtcgga 1498201 aatattatga gagacagtct gccggaactt ggtgtgaagc cccggaaaaa tcaaatcgag 1498261 aaaaaatacc aatggaacga cacaaaaaca atagaagttc cgaatgttgt agggatgtct 1498321 gtctcagatc ttgagtcact attggtgaat ctcaatgtgg atgcttccgg gaaagggagc 1498381 aaaatcgtta aacaatcgcc agctgccgga acgaaagtaa aagaaggctc aaagatacgc 1498441 gtgtatttga ctgaagaaga tgaaaaggag gcagccgatt gattcgggct gcctattctt 1498501 ttattgcaga aaaaatgctg atatctttca agattagctg gatgtatcct tttatttacg 1498561 ctaaaatatg aactgtatgc ttaaaatcat taccacatca tttgatgtga cttcaatgat 1498621 aaaaagaacg aattagaatg ttgagaggtt tgatacgatg aaacttacaa agctgcttac 1498681 atacttaaca accgaacctt ctgtaaacga ctcacaagac cctgaaataa cttcaattga 1498741 gatggactcc agggaagtaa agaaagggag tctttttgta tgtgtaaaag ggtatacggt 1498801 ggatggccac gattttgcgc aaaaagcagt agaaaacggt gcagcggcta ttgtggcaga 1498861 aagagaggtc gatgtgaatg ttcctgttat tattgtccgg cagtcacttc gcgcgctcag 1498921 cgttttgtct gatgcgtttt acggacagcc gacgaagaag cttcagctga ttgggataac 1498981 agggacaaac ggcaaaacat caacgaccca catggtcgat gagattctga aaaaagcggg 1499041 aaaacgcaca ggcttgatcg gtacaatgta catgaaaatc ggagacgaaa cacttcctgt 1499101 taaaaacacg actccggaaa gcgtcacgct gcagaaaacg tttaagaaaa tgaatgacaa 1499161 gcacgttgac actgcaatca tggaggtttc ttcccacgct ttgtctttag gacgcgtcca 1499221 tggctgtgat tatgatattg ccgtgtttac gaatttaaca caggaccatc tggactatca 1499281 taaaacgatg gatgagtacc ggcatgcaaa aagcttgctc ttttcccaac ttggcggggc 1499341 tttcaaccat gaacatccaa agcgtgccgt cctgaatgct gacgatgagg cgagcgctta 1499401 ttttgaaaag gtaacagctg cgcatatctc tacatacgga attaaaaacg atgctgatgt 1499461 gatggcgaag aacatcagta tcactgcaca gggcacaagc tttgatctcg tgacaaacaa 1499521 aggcacgaag cacatcacga tgtctctcgt cggacaattt aatgtgtata acgtgctggc 1499581 cgctgttgcg acatgtattg cagcaggcat accgtttgaa atcatcactg aggctgttga 1499641 agaattgcat ggtgtaagag gccgttttga attggtcaat cagcagcagg agtttcctgt 1499701 cattgtagac tacgcgcaca caccggacag ccttgaaaat gtgctggaga catgcagaga 1499761 catgacggaa ggaaagctat ttgtcgttgt cggctgcgga ggagacagag ataagacgaa 1499821 gcgcccgaaa atggctaaaa ttgctgtgga gctggctgac gagccgattt tcacgtcaga 1499881 taacccgaga agcgaagatc ctcgcgcgat tttaagagat atggaagccg gagtagagaa 1499941 cgcatactat cacagtattg caaaccgcga gcaggcgatc tttttcgcaa ttgccaatgc 1500001 caaaaaaggc gacgttgtcc tcattgccgg aaaaggacat gaaacctatc agcagatcgg 1500061 aaatgaaact ttcgattttg atgatgctga agtagcggcg agagccattg ttgaactcaa 1500121 taagaataag acgaattcat aggaaagaga tgttactgaa taatggagct tgaaaagatt 1500181 tttcatatgg aaaaaaatca tgaatatgat aactacgtat gtcgtttgaa agaaacagga 1500241 ggagaaaagg acaatgcttg agcaagtcat tctgtttaca attttaatgg ggtttttaat 1500301 tagtgttctg ctctctccga ttcttattcc gtttttaaga agattaaaat tcggccagag 1500361 tattagagaa gaaggaccga aatcacatca gaaaaaatca gggacaccga caatgggcgg 1500421 ggtcatgatc atactttcta tcatagtgac aacaattgtt atgacacaga agttttcaga 1500481 aataagcccc gaaatggtgc tgcttctgtt tgttacgcta ggctacggtt tgcttggctt 1500541 tttagatgat tacatcaagg ttgtcatgaa gcgcaatctt ggattgacat caaagcaaaa 1500601 gctgatcgga caaattatta ttgcggttgt attttacgcc gtgtatcatt actacaattt 1500661 tgcgacggat attcgcattc ctggaactga cttatcattt gatcttggct gggcttactt 1500721 tatccttgtg ctctttatgc tagtcggcgg atcaaacgca gttaacctga ctgacggcct 1500781 tgacgggtta ttatccggta ctgcggcgat tgcctttggc gcctttgcca ttctggcatg 1500841 gaatcagtct caatatgacg tagcgatttt ctcagttgcc gttgtcggtg cagttctggg 1500901 cttccttgta tttaatgctc atccggccaa agtttttatg ggagatacgg gatcgcttgc 1500961 attgggagga gccatcgtta ccattgccat tttaacgaaa ttagagatcc tgctggttat 1501021 catcggcggt gtattcgtta tcgagacatt atccgttatt ttgcaggtca tcagctttaa 1501081 aacgacaggt aaacgaatct ttaaaatgag tccgcttcat caccattatg agcttgtcgg 1501141 ctggtctgaa tggagagtag tcgtgacgtt ttgggctgcg ggacttttgc ttgccgtttt 1501201 aggaatttac atcgaggtgt ggttataagt ggaaaatgat caatttttac agaaacagca 1501261 ttttttaatc cttgggcttg cgaaaagcgg atatgcggcg gcctccattc ttcatgaaaa 1501321 aggcatttat gttgcagtca atgatcaaaa gccttttgaa gaaaatgaac cggcacaaaa 1501381 gctttctgaa aaaggaatcg aagttgtttg cggagagcat ccagtttctc tgttcgatca 1501441 gcatcaaatc acgattctga tcaaaaaccc gggaattcct tatgaaaata tcatggttca 1501501 ggaagcagag aaacgaggta ttccggtttg gacggaaatt gagctcgctt actacctgac 1501561 cagcgccaag tttatcggga ttaccggatc gaacggtaaa acgaccacga caacgctaat 1501621 ttacgaaatg ctcaaggctg actcgcaaaa agcactgatt gccggaaaca tcggcacagt 1501681 cgcaagtgag gttgcctatc atgctgatgg agatgaatgg atcgttaccg aactgtcttc 1501741 gtttcagctg atgggaacac acgctttcag accggaaatc agcctgattt taaatgtatt 1501801 tgacgcccat ctggattatc accatacgcg cgaaaactat gaaaaagcga aacagaaagt 1501861 gtaccttcat cagactgctt cagataaagc tattgtcaac caggatgatg aaaccgtcgt 1501921 gcgtcttgct gaagccggaa aagccgaaat cgtcccattt tcagtcagca aaacgcttga 1501981 acagggcgca tatgtaaaag acagtatgat tatgtttaac ggcgaagcca ttcttcctct 1502041 ggaagaggtt gtactgcccg gtgctcataa cctggagaac attttagcag ctattgcagt 1502101 tgtgaaaacg gcaggagcat ccaatgaggc ggttaaaaag gtgctgacaa gctttactgg 1502161 tgtgaagcac cgcctccaat atgtcacaac tgtgaatggc cgcaaatttt ataacgacag 1502221 taaagcaaca aacattctgg cgacaagcaa ggcgctttca gcttttgata agccggtcat 1502281 tctgcttgcg ggcggactgg atcgcggaaa tggttttgat gacttgaaac cttatatgaa 1502341 gcatgtcaaa gcagtgctta catttggcca gacggcgcca aaactcgaga aactcggcaa 1502401 tgaactggga atacaacatg tcaaacgtgt cgataatgtt gaacaagcag tatctgcggc 1502461 gtttgcgctc tcaaatgaag gagatgtcat cctgctgtca cccgcgtgtg cgagctggga 1502521 tcaattcaaa acatttgaag aacgcggtga catgtttata gatgccgtgc atatgcttaa 1502581 gtaagggctt gtcttgaagt aaatcggcag ccctaatgac tttaagcttg gggtgtcgat 1502641 tgctttgact actaaaaaaa catcgcctga tttgttattg gtcatcatta cgttattatt 1502701 attaacaatc ggattaatta tggtgtacag tgcgagtgcg gtatgggcgg attataaatt 1502761 tgacgactca ttctttttcg cgaaacggca gcttttgttt gcgggaatcg gcgtcattgc 1502821 tatgtttttt atcatgaatg ttgattattg gacttggagg acatggtcca aattgctgat 1502881 ggttatctgc tttttccttc tggtgcttgt tttgataccg ggcgtcggaa tggtgcggaa 1502941 cggttcaaga agctggatcg gagtcggagc attcagcata cagccttcag agtttatgaa 1503001 gcttgcgatg attgcattcc ttgctaaatt tctctctgaa aaacaaaaaa acatcacatc 1503061 gttcagacgg gggttcgtcc ctgcacttgg catcgtgttt tcagcatttt tgattatcat 1503121 gtgccagcct gacctcggaa cggggacagt tatggtcgga acttgtattg tcatgatttt 1503181 tgtagccggc gcacggatcg cccatttcgt ctttctcggg ctgatcggcc tcagcggatt 1503241 tgtcgggctc gtactatcgg ctccatatcg gataaagcgg attacctcat acttaaatcc 1503301 atgggaagac ccgctcggaa gcggatttca gatcattcaa tcgctttatg cagtggggcc 1503361 cggcgggttg ttcggaatgg ggctcggaca aagcagacag aagttctttt atctgcctga 1503421 gccgcaaaca gactttattt tcgccatctt gtcagaggag ctgggcttta tcgggggaac 1503481 acttattttg ctcctcttca gcgtcctgct gtggagagga atcagaattg cgcttggtgc 1503541 gcctgatctg tacggaagct ttgtcgcagt cggcattatt tcaatgattg ccattcaagt 1503601 catgataaat atcggcgtag tcacgggcct gattcctgta acaggcatca cgctcccgtt 1503661 tctgagctac ggaggctctt cattgactct aatgctgatg gcagttggtg tgctgctgaa 1503721 tgtaagccgc tactcgaggt attaacgaat gtatttccaa gcctcctgtc taacatgaag 1503781 cttggaaaca attgatgcga taaccctgtc caacaaaaca gggttatcgt tatgttatag 1503841 agaaacttag actgggggaa aaaagaaatg cgaattgcaa taagcggagg cggtacaggg 1503901 ggacatattt atcctgctct tgcttttatt aaagaagtgc aaagacgtca tcctaatgtg 1503961 gaatttttat atatcggaac agaaaacggg ctggagaaaa aaattgttga gcgggagaat 1504021 ataccgtttc gttcaattga aattacagga tttaaaagaa aattgtcatt tgaaaatgtc 1504081 aagactgtga tgcgttttct gaagggcgtc aaaaagagta aatcgtattt agcggaattt 1504141 aagcccgatg ccgtaattgg aacgggcggt tatgtatgtg ggccggttgt ctatgccgct 1504201 gcgaaaatgg gaattccgac tattgtccac gaacaaaaca gcctgccggg catcacgaat 1504261 aagtttcttt caaaatatgt taataaagta gcgatttgtt ttgaagaagc gaaatcacat 1504321 tttcctagcg agaaagttgt atttacggga aacccgagag cctctgaagt cgtctcaata 1504381 aagacgggac gatcattggc tgaatttggg ctttctgaag acaaaaaaac ggtcttaatt 1504441 ttcggcggaa gccgaggcgc tgcaccgatt aaccgcgctg tcattgacat gcaggatgtg 1504501 ctgaaaacaa gagactatca agtgctgtat atcaccggtg aagttcacta tgaaaaagta 1504561 atgaatgagc tgaaaagcaa gggtgccgct gataatatgg tcacaaagcc gtttcttcat 1504621 caaatgcctg agtatttaaa ggccattgat gtcattgtgg ccagagccgg tgcgacaacg 1504681 attgccgaaa ttactgctct cggaatccca agtgttctga tcccaagtcc atatgtgaca 1504741 gcgaatcacc aggaggtcaa tgcgaggtct cttggccagc atgatgcggc gattgtactg 1504801 aaagaaacag agctcagcgg ggagaagctg attgaagcgc tagaccggat tgtactgaat 1504861 gagcaaacgt taaaggaaat gagcgaacga acaaagtcac tcggtgttcc tgacgcggct 1504921 gcccgtttat acagcgtact cgaggaatta aaaaaatagt agaaaagcaa atggaatgcg 1504981 gaggtttacg atggagaaag tgatacagga attaaaagaa cgagaagtcg gcaaggttct 1505041 tgcaaatgaa ccgctcgcga atcatacaac gatgaaaatc ggcggacctg cggatgtatt 1505101 ggtcattcca agcagtgtgg atgctgttaa agacatcatg gacgtgatta aaaaatatga 1505161 tgtgaagtgg acagtcatcg gccgcggatc aaatcttctt gttttagatg aaggaattag 1505221 aggcgtagtg atcaagctgg gggcgggtct tgaccatttg gagcttgaag gggaacaagt 1505281 aacagtcgga ggcggttatt cggtggtccg ccttgctaca tcattgagca aaaaaggcct 1505341 gtccggtttg gaatttgctg ccggcattcc aggatcagtc ggcggagcgg tttatatgaa 1505401 tgccggcgct cacggttctg atatgagcga gatcctcgtc aaagcgcata ttttatttga 1505461 agacggaacg attgagtggc tgacaaatga gcagatggat ttcagctaca ggacatctgt 1505521 actgcaaaag aaacgcccgg gcgtttgcct tgaagctgtt ttgcagcttg agcagaagga 1505581 taaggaatca atcgttcagc aaatgcaaag caataaagac tatagaaaaa atacacagcc 1505641 gtattcaagc ccttgtgcgg gaagcatatt cagaaatccg cttccgaatc atgccgggaa 1505701 ccttgtagaa aaagcaggct tgaaaggata tcaaatcggc ggtgcaaaga tatcggagat 1505761 gcacggaaac ttcatcgtca atgcgggggg agcatcagca aaagatgtgc ttgatctcat 1505821 tgaccatgtg aaaaagacaa tccgtgaaaa atacgagatt gatatgcaca cagaggttga 1505881 aatcatcggc ggaaatcgct gattcaagtt ctgactgaag ctgttcatat gatatactgt 1505941 aagcaaacga caaacggcat catagtatgc cgtttgtttt ggaatagaca gacttttaac 1506001 agctgtttca tttgaatgag gtgaacaggc aatgaacccg ggtcaagacc gagaaaaaat 1506061 cgttaacatt gaagagcgga tccctaaaat taaagagcag aggaaacaaa aggcaaaccg 1506121 ccgtctcatt tcatttatta tgctcttttt tattatggtg ctgatcattg tgtacctgca 1506181 aacaccaatc agtaaagtat caacaatctc tgttacaggg aatgaaaatg tatcaaaaaa 1506241 ggaaattatc gacctttccg atattaacag cggagatact gagttttgga gtttggacaa 1506301 gcaaaaaaca gaaaagaaga ttcagcaaaa taaattagtg aaaaaagcgg agatcagcaa 1506361 atcgcttcct aataaaatca acattgcaat cgaagaatat aaagcgattg cttatttaga 1506421 aaaagacgat gtgtactatg aagtgcttga aaacggctca gttctgccaa acgaagtaac 1506481 gccggatgat gccggaccga ttttagtgaa ttggacaaac gcgaagaagc ggtctcaaat 1506541 ggccaagcag ctcgatgcgt tgtcaaattc gttaaaacag tcgatttcag aaatttatta 1506601 tacgcctgta aaaatggatg aaaaccgtat taagttgtac atgaacgacg gttatgttgt 1506661 tacggcatct attaaaacgt ttgcagaccg aatgaagacg tatccttcta tcatctcaca 1506721 gctaagcagc aataaaaaag gaatcattca tttagaagtt gccacctatt ttgaagagtt 1506781 tgggaaaaac gataaagctg ctaaaaagga agatgaaaat tgaggggcaa atcagcagtc 1506841 cttctttcct tgattatgct tatcgcaggt tttttgattt cattttcttt tcaaatgaca 1506901 aaagaaaaca acaaaagcgc ggctgagacg gaagagtgga aaaaagaata tgcgctgaga 1506961 gatgaactgc tgaaacaaga gaaagaaaat aagaagtttg aaaaagaatt atatcaaaag 1507021 caaaacaaag tccgccaggc ggaaaataag ctgaagaaag agaagtcgga atactataat 1507081 gtcctcgaag atacagaaaa atacaggatg tatattgggg aagtcggtgt gcagggagaa 1507141 ggcgttgagg tgacattgga agatgcgtca tacataccgg aaggggagaa tgtgaatagt 1507201 tacatcgttc acgaaagcca tatcttccaa gtagtaaacg aactgtatat ctcaggagcg 1507261 gcagctgtcg ccgttaatgg acagcgtttg acgcatgatt cgtatatcaa atgcaatggt 1507321 cctgtggtaa cggtagacgg ggtgcagcat cccgctccgt ttacggtatc cgctattgga 1507381 gatccagatg tcctgctgcc ctcgttaaat atcgctggag gcctaattga tcagctgtca 1507441 atggatcata tttctgtgtc ggcagaaaaa gagaaaaacg tacaaatgaa accgattctg 1507501 aaaacgaagg aatgactgaa aaagcgggtg aaatagattg aaaataaagc gttccttcat 1507561 aagcatcagt gttcttatgg tcatcttcgg cctgatgata tctgttcagt ttaattcgtt 1507621 aaagcacccc aaagtccggg atacaagaga tatgtgggat attagggaag agctgacatc 1507681 agagcagaag aagcaggaaa agctgctggc tgaaataaac aaatatgaca aattgctgaa 1507741 tagctattcg caaacgaaag aaatgacaaa agaaaccgcg ctaaataata ccttgcaatc 1507801 cttaaaaaaa acagccggca tgaccgatat aacaggtagc ggaattgtca ttacgatttc 1507861 cccgcttttt tctgaaagct taacaggaga gccgatcgaa aatccgcctc cggatttgct 1507921 gaaaaagctg ataaatgaac tcaactccta cggtgcagag catatctcga ttaatgagcg 1507981 aagagttgtg aatcatacag tcatcagaga tataaacggc actacaaaaa tagacggata 1508041 cgcccttgac gattatcctt taacagtaaa agtgcttgcc aaagatccgg acatgttaca 1508101 cagcagagtg aaggggtcag gccttgagga tctttttgca tctgaaaatt tagcattaaa 1508161 agccggtaaa tctgaaagca aactaacatt aaaagcatat gacagaccac tggacgtaca 1508221 acagctgaaa ctgcttaaag actgaaaagg aggagaattg tcatgtggct gcccgtgttg 1508281 ggactggtgc tcggaatagc gattggacta atgacaaact taacgatacc gagtgaatac 1508341 tcaaactatt tatcgcttgc ggtgcttgcc gcacttgata cattaatcgg cggaatcagg 1508401 gcgcatttac aaggtacata tgatgaaatg gtatttgttt ccggtttctt ttttaatatt 1508461 atattggcaa taagtttagc ttttctggga gtccatcttg gtgtagactt gtatttagca 1508521 ggtatattcg catttggagt cagattattt cagaatatag ccgttatcag aagaaatcta 1508581 ctaacaaagt ggactctttc taaaaaaaat aaaaaaaatg tgatataaaa gaggatatac 1508641 ataggatata acgaatattt tcaataaaca taaaatgtga aaagcacata aaaatattct 1508701 gttgttattt tttgttacac acttgtaaag ccacattcat tgtattgttg ttccgcaaat 1508761 aatagaatag aaatgatcga aatgtgagga ggtgccatag aatgaacaac aatgaacttt 1508821 acgtcagtct tgacatcggt acgtccaata caaaagtgat cgtcggagaa atgacagatg 1508881 attcccttaa tattatcggt gtgggaaatg taccgtctga agggttgaaa aaaggctcaa 1508941 tcgttgatat agatgagacc gttcattcta taagaaaagc gtttgaccaa gctgaaagaa 1509001 tggtaggttt tccgcttaga aaagctattg tcggcgttaa tggaaattat atcaatattc 1509061 aagatacaaa cggtgttgta gcagtttcca gtgaaaataa agaaattcag gttgaagatg 1509121 tacgccgtgt catggaggcg gcacaggttg tttccgtacc gcatgaacag ctgattgttg 1509181 acgtcattcc taaacagttt atcgtagatg gaagagatga aatcaccgac ccgaaaaaaa 1509241 tgctgggtgt gcgtttagaa gtagagggca ccttgatcac cggttcaaaa acaatcttac 1509301 ataacttact ccgctgcgtt gaaagagctg gtattgaaat aactgatatt tgccttcagc 1509361 cgctggcagc cggttctgct gcattatcaa aggacgagaa aaaccttggt gtggctctca 1509421 ttgatatagg gggagggtca acaaccattg ccgtattcca gaacggacat ctcacttcta 1509481 cccgtgtcat tcctctcgga ggcgaaaata tcaccaaaga tatctccatc ggattgagaa 1509541 cgtcaacaga agaagcagaa cgcgtgaaaa agcaacttgg acatgcctac tatgacgaag 1509601 cctcggaaga tgaaatattt gaggtaaccg ttataggcac caatcaaaaa caaacattta 1509661 cacagcaaga agcagcgaat atcattgaag cgagagtaga ggaaattctt gaaattgttt 1509721 cagaagagct tcgcagtatg ggaattaccg atctgccggg aggcttcgtg ctgacaggag 1509781 gacaagcagc tatgccgggt gtcatgtctt tggcacagga tgtgctgcaa aacaatgtca 1509841 gagtggcaag cccgaattat atcggtgtaa gagatcctca atatatgacg ggagtgggcc 1509901 tgatccaatt cgcctgccgg aatgcaagaa tccaaggcag aaaaataggc tttaagatgc 1509961 ctgaagaagc gatacaggaa atcgcagtct catcatctga ggaacaagag cagcatcatc 1510021 accaaaatga ggtgcagcag cggccaaaag gaaaacaaaa aacacaagcc gaacataata 1510081 aacagagcaa aatgaaaaaa ctattaagca tgttttggga atagatagat agtcattcgg 1510141 cagattagga ggatttagca tgttggagtt cgaaacaaac atagacggct tagcatcaat 1510201 taaagtaatc ggagtaggag gcggcggtaa caacgccgtt aaccgaatga ttgaaaatga 1510261 agtgcaagga gtagagtata tcgcggtaaa cacggacgct caagctctta acctgtcaaa 1510321 agcagaagtg aaaatgcaaa tcggcgcaaa gctgactaga ggattgggag caggtgcgaa 1510381 tccggaagtc gggaaaaaag ccgctgaaga aagcaaagag cagattgaag aagcacttaa 1510441 aggtgctgac atggtattcg tgacagctgg tatgggcggc ggaacaggaa caggtgccgc 1510501 accggttatc gcacaaatcg cgaaagactt aggcgcatta acagtcggcg ttgtgacaag 1510561 accgtttacc ttcgaaggac gcaaaagaca gcttcaggct gcaggcggaa tctcggcaat 1510621 gaaagaagcg gtggatacac tgatcgtgat cccgaacgac cgtatccttg aaattgttga 1510681 taaaaacaca ccgatgcttg aagcattccg cgaagcggat aacgtacttc gccaaggggt 1510741 tcaaggtatt tctgacttga ttgctacacc tggtcttatc aaccttgact ttgctgatgt 1510801 gaaaacaatc atgtcaaaca aaggatctgc tttgatgggt atcggtattg ctactgggga 1510861 aaatcgcgcg gcagaggcag caaaaaaagc aatttccagc ccgcttcttg aagcggccat 1510921 tgacggtgcg caaggcgtcc tcatgaacat cactggagga acaaacctca gcctatatga 1510981 ggttcaggaa gcagcagaca ttgtcgcttc ggcgtctgat caagacgtaa acatgatttt 1511041 cggttctgtt attaatgaaa atctaaaaga tgagattgtg gtgacagtga ttgcaaccgg 1511101 ctttatcgaa caagagaagg acgtgacgaa gcctcagcgt ccaagcttaa atcaaagcat 1511161 caaaacacac aatcaaagtg ttccgaagcg tgagccaaaa cgtgaggaac ctcagcagca 1511221 gaacacagta agccgtcata cttcacagcc ggctgatgat acgcttgaca tcccgacatt 1511281 cttaagaaac cgtaataaac gcggctaatg taaaggacaa aatcgttttc gattttgtcc 1511341 ttttttgttt ttctcttcac actttccttc ttataaagtc tttttcccta ttgcttcctt 1511401 cgcttagtaa caaaacagat aattagaccc atttattttt gtgacatttt tatcattttc 1511461 atatatatgg aaattgaatg acatgaaacg acaatatctg taattcagat tgtctacagt 1511521 taatatacag cgatgttctg acaaaccatt cattattaaa aggagggacg acactttttt 1511581 taaaaagcat gttgaaaaag ggggatgaaa atgaggaaaa aaacgaaaaa cagactcatc 1511641 agctctgttt taagtacagt tgtcatcagt tcactgctgt ttccgggagc agccggggca 1511701 agcagtaaag tcacctcacc ttctgttaaa aaggagcttc aatctgcgga atccattcaa 1511761 aacaagattt cgagttcatt aaagaaaagc tttaaaaaga aagaaaaaac gacttttctg 1511821 attaaattta aagatctggc taacccagaa aaagcggcaa aagcggctgt taaaaaagcg 1511881 aaatcgaaga agctgtctgc cgctaagacg gaatatcaaa agcgttctgc tgttgtgtca 1511941 tctttaaaag tcacagccga tgaatcccag caagatgtcc taaaatactt gaacacccag 1512001 aaagataaag gaaatgcaga ccaaattcat tcttattatg tggtgaacgg gattgctgtt 1512061 catgcctcaa aagaggttat ggaaaaagtg gtgcagtttc ccgaagtgga aaaggtgctt 1512121 cctaatgaga aacggcagct ttttaagtca tcctccccat ttaatatgaa aaaagcacag 1512181 aaagctatta aagcaactga cggtgtggaa tggaatgtag accaaatcga tgccccaaaa 1512241 gcttgggcac ttggatatga tggaactggc acggttgttg cgtccattga taccggggtg 1512301 gaatggaatc atccggcatt aaaagagaaa tatcgcggat ataatccgga aaatcctaat 1512361 gagcctgaaa atgaaatgaa ctggtatgat gccgtagcag gcgaggcaag cccttatgat 1512421 gatttggctc atggaaccca cgtgacaggc acgatggtgg gctctgaacc tgatggaaca 1512481 aatcaaatcg gtgtagcacc tggcgcaaaa tggattgctg ttaaagcgtt ctctgaagat 1512541 ggcggcactg atgctgacat tttggaagct ggtgaatggg ttttagcacc aaaggacgcg 1512601 gaaggaaatc cccacccgga aatggctcct gatgttgtca ataactcatg gggagggggc 1512661 tctggacttg atgaatggta cagagacatg gtcaatgcct ggcgtgcggc cgatattttc 1512721 cctgagtttt cagcggggaa tacggatctc tttattcccg gcgggcctgg ttctatcgca 1512781 aatccggcaa actatccaga atcgtttgca actggagcga ctgatatcaa taaaaagctc 1512841 gctgactttt ctcttcaagg gccatctcca tatgatgaaa taaagccgga aatatctgca 1512901 ccgggcgtta atattcgttc atccgttccc ggtcagacat atgaggatgg ttgggacggc 1512961 acatcaatgg cagggccgca tgtatccgct gttgctgcac tgctgaaaca ggcgaatgcc 1513021 tcactttctg ttgatgagat ggaggatata ttaaccagca cggctgaacc gctcacggat 1513081 tcaacatttc ctgattcacc gaataacgga tatggccatg gtctggtgaa tgcttttgat 1513141 gctgtatccg ctgttacaga tggattaggg aaagcggaag gacaagtttc tgtagagggg 1513201 gatgaccaag agcctcctgt ctatcagcat gagaaagtaa ctgaagctta tgaaggtggc 1513261 agcctaccac tgactttgac agctgaagac aatgtgagtg tgacatctgt aaagctgtcc 1513321 tacaagcttg atcaaggtga atggacagaa ataacggcta aacgaatcag cggtgatcat 1513381 ctaaaaggaa cgtatcaggc agagatccca gatataaaag gaactaaact aagctataag 1513441 tggatgattc acgattttgg cggtcatgtc gtttcgtctg acgtatacga tgtaacagtg 1513501 aaaccaagca tcacggcggg atataagcag gactttgaaa ctgcacccgg cggctgggtt 1513561 gcgagcggaa caaataataa ctgggaatgg ggagttccgt caactggccc aaatacagca 1513621 gcatccggag aaaaagtata tggaacgaat ttgacaggaa attatgccaa ctcagcaaac 1513681 atgaaccttg ttatgcctcc tattaaagca cctgattcag gaagtctgtt ccttcaattt 1513741 aaaagctggc acaatttaga ggatgatttt gattacggct acgtttttgt tcttccggaa 1513801 ggtgaaaaga attgggagca ggctggtgtc tataacggaa agacatcaag ctggacggac 1513861 gaagaaattg atttatcggc ttataaaggc caaaacattc aagtgatgtt taaccttcaa 1513921 tctgatgaaa gcattgcaaa agagggctgg tatattgatg atgtagtgct ttctgacaaa 1513981 tcagccggaa aaacagtcaa aaagaataag ctgggcgtcg aaaagccgtc tggaaagcaa 1514041 aagaaaaagc cagtaaatcc gaaaaaggct aagccatctg caaacacagc ggtaaaacat 1514101 cagaacaagg ctatacagcc tcaagttttg ccgctcaagg cacaagtcag tgtagtggaa 1514161 acaggaaaat caacatattc agatcaatcc acagggcagt acacgctgaa gcacaaagcg 1514221 ggagactata cgcttatggc agaagcatat ggttatcagt cgaaaacaca aaaagtatct 1514281 ttaaagacgg atcagacgac acaagctaat tttacgttag aagagatgaa gaagggcaca 1514341 ttaaaaggca cggtcatcaa taaaacgaca ggagagccgg taacaggcgc ttccgtttat 1514401 gttgtagagg atgctgcggt ggaaccggct atgacaaacg acaaaggtga atatatgctg 1514461 gaggcctatg aaggcgctta tacgattaaa gtcgctgcac cgggttatta cagtgatgaa 1514521 ttttccgttg agttaaaagg tgatgttaca aaagaaactg cattgaagcc tttcgtcggt 1514581 tatccgggtg aaattgcata tgatgacgga acagcggaga atgccaattc ctattttgct 1514641 gccggtaacg gatgggcggt aaaaatgacg ctcgctgacg gcaaggacaa aggcatgctt 1514701 acaggagggc tgttcagatt ctgggataca gagttccctg atccgggcgg cacagagttt 1514761 aaggttgagg tatacgatgc cacaggaaaa gacggagcac cgggcaagaa aattgcaggg 1514821 ccatttaacg cggaagctct tcgcaatggc gagtggacta aggtagatct cagttcaaaa 1514881 gggattatgg tcgataaaga tttttatctc gtatatatcc agtcgaaacc tgatccgtat 1514941 tcacctggat tggcaatgga tgaaaccggc cagaattccg gccgcaactg gcagtatata 1515001 gatggaaagt ggcagccagg tgacaaagcg gatggcaact atatgattcg cgcattagtt 1515061 gattatgaag ctgctgtacc tgagattact tcaccgacag acaaatcata cacaaataag 1515121 gatagcgtca ctgtaaaagg aaacgcttct cctggcacaa cggtacacat ttataatgga 1515181 gagaaagaag caggagaaac gaaagctgct gcggatggca cgttccatgc aggcatcata 1515241 ctcaacaagg gtgaaaatga gctgacggca actgcatcaa ctgacaacgg aacaacagat 1515301 gcctccagcc caatcacggt cacgcttgat caagaaaagc ctgaattaac actggacaat 1515361 ccaaaggatg gcgggaaaac aaataaagaa acgctgactg tcaaaggggc tgtatccgat 1515421 gacaatctga aagacgtcaa ggtgaatggc aaaaaagcaa cagtagctga tggttcatac 1515481 tcagcccgta ttcttttgga aaatggaaga aatgaaatca aggtaattgc tacagacttg 1515541 gcaggcaaca aaacgacgaa aaagacagtc attgatgtga actttgacaa gcctgtcatt 1515601 tccggcttaa ttccgggaga ggataaaaac ttaaaagccg gtgaatctgt gaaaatcgct 1515661 ttctcaagcg ctgaggattt agatgcaacg tttaccattc gtatgccgct gaccaatgca 1515721 agagcgagtg tgcaaaatgc caccgaactc ccgttaagag aaatctctcc ggggagatat 1515781 gaaggctatt ggactgccac ttcttctatt aaagcaaaag gagcaaaagt agaagtgatc 1515841 gtccgagatg attatggaaa tgaaacaaga aaaactgcga atggaaaact taatatgaac 1515901 acagaaaatt aagtggaaaa aaagctgccg tcattggcag ctttttttat atcctctcat 1515961 tatacttcct cgacaaatta agcagatttc cctgaaaaat tgtattttcc tctcaacatt 1516021 aattgacaga ctttcccaca gagcttgctt tatacttatg aagcaagaag gggaacagcg 1516081 tgaggcaaga aagaaaggag tcagatgtga aaatctattt agatgtcatt tggctgttaa 1516141 acttttgttt tgatgcactt ttgcttttgc tcacggcatt tattttaaaa cggcatgtaa 1516201 aaaaaagaag actggtaggc ggagcgttca tcggttccag tattgtcctt ttgatgttta 1516261 ctcctttttc gccgattgtt gaacatccgg ctgggaagct agctttttca gttgtgattg 1516321 tggtggtgac atttggcttt aaaagatttc ggtttttctt tcaaaatttg ttttcctttt 1516381 attttgccac ttttttaatg gggggaggaa ttatcggagc ccattctttg ctgcagtcaa 1516441 attctattgt tcaaaacggt gtcatgatta ccaatcaaac agggtttgga gacccgatca 1516501 gctggttgtt tattgttggt ggctttccag cattatggtt tttttctaaa agaagaattg 1516561 aagatattga aacaaaaaac attcaatatg aggaacgagt cagcgtgcag gcagatttgg 1516621 gcagccaaac acttcatgtc agaggcctga ttgattccgg taaccagctg tacgatcctc 1516681 ttacaaaaac accggtaatg atcatttaca ttgataaact ggagccgatt ttcggaacag 1516741 ccgaaacgat gatcattcga aacacagacc cattggaagc catcgaacag ctcgatgatt 1516801 cctttcgctt tttagataaa atgaggttga ttccatacag gggagttggt cagcaaaatc 1516861 aatttttatt atgcgttaaa ccggatcacg taacgattat gacaaaagaa gaaatgattt 1516921 ctgcagataa atgtttaatc ggtatcagca caacaaagct gtcggcagat ggagagtttg 1516981 acgcgattat tcatccgaaa atgctttcgg gcaaggctgt caaacacgtt tcataatgtt 1517041 cgcaaatgtc cgttacttat catactcaaa cggcgtgaca tttagaaggg agaggaagat 1517101 gaaaaaactg aaattacggt tgacgcacct ctggtataag ctgctgatga aacttgggct 1517161 gaaaagtgat gaagtctatt acataggcgg gagtgaagcc ctgccgcctc cattatctaa 1517221 agatgaggag caggttttgt taatgaagct cccaaacggc gatcaggcgg cgcgcgccat 1517281 tctaattgaa cgcaatttgc gtctggtcgt atatatcgcc cgtaaatttg aaaatacggg 1517341 aattaatata gaggatttaa tcagcatcgg taccatcggt ctaatcaaag ctgttaatac 1517401 atttaatcca gaaaagaaaa tcaagcttgc tacctatgcc tcccggtgta tagaaaatga 1517461 aatcctgatg tatttaagaa gaaataacaa aatccgttca gaggtttcct ttgatgaacc 1517521 gcttaatatt gattgggacg gcaatgagct tttgctttct gatgtgctcg gcactgacga 1517581 tgacatcatc actaaagaca tagaagctaa cgtcgataaa aagcttttga aaaaagcgct 1517641 tgaacagctt aatgagagag aaaagcaaat catggagctg cggtttgggc ttgtcggtga 1517701 agaagaaaaa acccaaaagg atgtagcgga tatgatgggg atttctcagt cttatatttc 1517761 gcggcttgag aaaagaatta taaaaaggtt gagaaaagag ttcaacaaaa tggtgtaaaa 1517821 aattttatgg ttagaacccc ttgattttac agggatttcc tgatttcgac agtttttcgg 1517881 tctgagtgca gtgcatattt ttcccaccca aggagatact taacgttgta cagcagctcc 1517941 tgtagggagg gaaaaaagtg tcgagaaata aagtcgaaat ctgcggggtg gatacctcca 1518001 aattaccagt actcaagaat gaagagatga gaaagctgtt taggcagctg caggatgaag 1518061 gcgatgattc agcaagagaa aagcttgtaa acgggaactt gcgtcttgtc ttaagtgtca 1518121 ttcaacgatt taataacaga ggggagtatg ttgatgactt atttcaagtc ggctgcatcg 1518181 gactaatgaa atccattgat aattttgacc taagccacaa tgttaagttt tcaacatacg 1518241 ctgtacctat gattatcgga gagatccgca ggtatttacg tgataataac ccgatccgtg 1518301 tctcaagatc actccgggac atcgcttaca aggcgcttca ggtaagagag cggttaatca 1518361 gtgagacaag caaggagccg actgcagaag acatcgcaaa agttcttgaa gtaccgcatg 1518421 aggaaattgt atttgcgctt gatgccattc aggatccggt ttctctattt gaaccgatct 1518481 ataacgacgg cggagacccg atctatgtga tggaccaaat cagtgatgag cgtaatacag 1518541 attcacaatg gattgaagag ctggctttaa aagagggcat gagaaggctg aacgataggg 1518601 aaaaaatgat tttgagaaag cgattcttcc aagggaaaac ccaaatggaa gtcgccgagg 1518661 aaatcggaat ttctcaagcg caggtgtcca gacttgaaaa agcggctatc aaacaaatga 1518721 ataaaaatat tcatcaataa tgaaaagcct ttaaaacgat gttgttttaa aggcttttct 1518781 attgattatg gatggtttac gttttggaaa aagtaaggta tcctagttcg tacaaagttt 1518841 tatgaaaatt aaaacaatta taaaaggcaa taaagaggag gaccacgatg attttgcagc 1518901 ttgacaatgt ctcactaaaa cggaatggga aatggatact gaaagatatt cattggaagg 1518961 tggaagaaaa ggaaaattgg gtgctttacg gcctaaatgg cgccgggaag acagcgctgt 1519021 taaatatgct ttgctcatat tattttccaa catcaggcga gatgcaggtg ctcggccatg 1519081 aatttggcaa aacagagctt ggggaaaagc tcagacgtaa aattggcctc gtctcagcag 1519141 ctcttcagca aaaattgtat ccggcagatt cagcttttga aattgctttg agcggagctt 1519201 acgcttcgat tgggttatat gaaacgccaa gtaaggaaac cagggaaaaa gcgataggtt 1519261 tgttagagga cttgggagca attgaatatg ccgatcgccg ctatgaaacc ctttctcaag 1519321 gggaaaaaca aagagcattg attgctagag cactaatggc cgatccggag ctgctgatac 1519381 tggatgaacc agtcacagga ctggatttta ttgcccggga aaagctgtta gatacgatta 1519441 catacattgc aaacaaagaa aatgcaccat ctatccttta tgtgactcat catgctgaag 1519501 aaattttgcc tgtctttgat aaagcccttt tattaaaaca gggagaggtt tttggatccg 1519561 gagaaataaa ggaaatgctt actgatcaaa tactttccgc tttttttgat acgccaatcc 1519621 atgtattatg gaatcaggat cggccgtttt taacaagagc tgagccgata acgaatgcct 1519681 gacaaatata tatagattca tcctaggggt gctttgcgaa gctgagagag actttgtctc 1519741 aacccttttg acctgatctg gatcatgcca gcggagggaa gcggtgaaaa gcggagtaca 1519801 tcggactccg tttgttttta ttaagccgtt tcatcacatt tgaaacggct tttttgattt 1519861 taaagaatag gagcggattt acattggatc aacaaatata ctctttgcaa aaaaaagtgg 1519921 aagaacataa ggaggagctt attcagcttg cgaaaacgct gatttcttat caaacacctg 1519981 ctccgcctgc aagaaataca gagggcattc agtcttggat tgcgggatat ttaaatgaat 1520041 tgggattctc gatcgacaaa tgggatgtgt accctggaga tcccaatgtt gtagggaagc 1520101 taaaaggaac agattcagca gattattata gcctgattat caatggccat gtagatgtgg 1520161 cagaggtaaa agaggatgaa gaatggaagc acgatccgtt tcatcccatt gaaaaaaacg 1520221 gtctcttaat cgggcgaggc gcttccgata tgaagggcgg aatggcttgt gtgctgtttg 1520281 ctgtcaaatt aattcgtgaa gcaagcattg aacttccagg tgatctgatt ctgcaatcgg 1520341 ttattgggga ggaagttgga gaggccggca cacttgaatg ctgcaagagg ggctaccacg 1520401 ctgattttgc aattgtcgcg gatacgagcg atatgcatat tcaaggccaa ggcggtgtca 1520461 ttacaggctg gatcgaaatc aaaagcagtc aaacatttca tgatggaacg agacggaata 1520521 tgattcatgc aggcggagga acattcggag caagcgcaat tgaaaaaatg gcaaaaatca 1520581 ttgcggggct cggtgaactt gagcgccact ggtctattat gaaaagttat cccggtttta 1520641 aaccaggcac aaatacgatt aacccggcag ttatagaagg cggcagacat gcggctttta 1520701 tagcggacga atgccggctg tggatcacag tccattttta tccgaatgaa acccatgacc 1520761 aagtggcagc ggaaatagaa gattacgtca atcggctgag tgacagtgat atttggctta 1520821 gggaaaaccg ccctgtattc aagtggggag gctcatctat gatagaagac aggggagaaa 1520881 tttttccggc attggaagtt gaccctggcc acccaggcgt cttagcgcta actgcctctc 1520941 atcagaaagt gaaacgggag tgtccaatta ttgacgtttc tcaatcagtt acagatggcg 1521001 gatggctgta tgatgccggt attccatgcg taatatacgg tcctggagat ctgcacaatg 1521061 cacactctgt gaacgagaag gtatcgattg agcagctagt agagtataca aaaattatac 1521121 tcgattttat catcagctgg tgcagccgga aaaaagaaca atgacatgaa aatttcttct 1521181 tgctgacaag gttcagcctg cccgttcata tacttgaaca aaaggacgga aaaaggacgt 1521241 gatggaatga tcagcatttc agaatttcag gtaaaggatg tcgtcaatgt ctcaaacgga 1521301 aaaaagctgg ggagtattgg tgatattgat atcaatgtga ccactggaaa aattcaggcg 1521361 atcatactcg gaggaaatgg gaaagttctc ggattttttg gaaaagaaga ggaattggtc 1521421 attccatggc gaaatatagt aaaaatcggg gaagatgtaa tcttagtccg attaagtgaa 1521481 ccacatgcat aaacctgctt gtctgccgca gattggcaaa tgccggaagt ctcgattctt 1521541 ccggcacatt tcatttagaa atatgcaaat cggcgctcaa cgaatgcagt aagatgtggt 1521601 aaaataagtg ggaaattccg cttttttaaa tgtttgtcga aaggttggat catcatgaat 1521661 acatatcacc cattcagtct taccacaccc tcgacactca tgatacaaga ctgggctcaa 1521721 acgaatcaaa acaacaaaga ggtcattgcc ggatttacga caaaaaacgg cggtgtcagc 1521781 caaaagcctt ttgaatcgtt aaatacagga ttgcacgttc atgacaaaga tgcagatgta 1521841 gttaaaaatc gtgaatatat tgccgatatg tttaatactg atttgcagtc ttgggtattc 1521901 gctgatcaga cacatgataa tcgcgttcag aaagtgacgc agagggatag gggaaaaggc 1521961 gcccgtgagt atcacacggc tctaaaagca acggacggga tctatacaaa tgaaaaaaat 1522021 gtatttttag cattatgctt tgctgattgt gtgcctcttt tcttttatga tccggttaag 1522081 tcgcttgtcg gagtcgccca tgccgggtgg aaaggcaccg tcaaacagat tggcagagaa 1522141 atggtgaagc aatggactga gaaggaaggt tcaaatccct cagatattta cgctgttatt 1522201 ggcccgtcta tcagcggagc atgctatacg gtagacgacc gcgtcatgga tgctgtccgc 1522261 gcattgccgg tttcagcaga ccttgccgcc aatcagacgg caaaggcaca atatcagctt 1522321 gatctgaaag agctgaaccg tcttatactg atggacagcg gtttggcaag tgaacaaatt 1522381 tctgtcagcg gtttatgcac ggaaagcgag ccgtctcttt tctattctca tcgccgcgat 1522441 caggggaaaa ctggacggat gatgtccttt atcggaatga aggaggcata aaagatcttg 1522501 cgtgttgttg ataatttacg acatataaac gaacgaataa acgaagcatg taacagatcg 1522561 ggccgcagct ccgatgaagt tacggttatt gcagtcacaa aatatgtatc acctgaaaga 1522621 gcacaggagg cagtagatgc tggcatcacc tgcctcggag agaatcggga tgcggaactg 1522681 ctccgcaaac aggaattgat gaaagggaat ccggaatggc attttatcgg cagtctgcaa 1522741 tcaagaaaag caaaatctgt cgtcaattcg gtttcctata tccattccct agaccggctc 1522801 tcattagcga aagaaattga aaaacgggct gaaggtactg tacgatgctt tgtgcaggtc 1522861 aatacctctc ttgagccttc taaacatggc atgaaaaaag aagaagtcat tccattcata 1522921 caggagcttt ccggtttcga acatatcctt gttgccgggc tgatgacaat ggctccgctg 1522981 actgatgatc aagatcagat cagaagctgt ttcaggtcgc tgagagaact ccgtgaccag 1523041 gttcagaagc tgaaccagcc gaacgctccg tgtactgaac tgtcgatggg catgtcaaat 1523101 gattttgaaa ttgcaattga agaaggagct acttatatta gaatcggctc atcgttagtc 1523161 ggaaatgaaa cagggggtgt acagcaatga gtatgaaaaa taaactgaaa aactttttct 1523221 caatggaaga tgaagaatac gaatatgaat atattgagac agagcgggaa tctcatgagg 1523281 agcatgagca aaaagaaaag ccggcttaca acgggaataa acctgcgggc aaacagaatg 1523341 tagtgagctt gcaaagtgtt cagaaatcct ctaaagtggt gttgagtgag ccgcgcgttt 1523401 atgcggaggc gcaggaaata gccgaccatt tgaagaaccg gcgggcagtt gtcgtcaatc 1523461 ttcagcggat acagcatgac caggcgaagc ggattgttga ctttttaagc ggaaccgttt 1523521 atgccattgg cggcgatatt caaagaatcg gctcagatat tttcctctgc acgcctgaca 1523581 acgtagatgt atcaggcaca atttctgagc tcatatctga agacgaacat cagaggtggt 1523641 aaagcgagat gatcctttat caagtttttt cggttttaag cttattaatc acaatatact 1523701 catttgccct gatcatatat atttttatgt catgggtgcc gagtacgagg gaaacagcag 1523761 tcgggcgttt tttggcttcg atttgtgaac catatctcga accattcaga aaaatcatcc 1523821 ctccgattgc aatgctggat atttcaccaa tcgtagcaat acttgtgctt cggtttgcga 1523881 caaccggctt gtggggactt tatcgcatga ttgcgtttta atgtgacagt ttgatagggg 1523941 cttggcagca gccaagcctc tttacataga agggaaagac gatgagcgat atatatcagc 1524001 acttcagaaa agacgagcgg gcctttattg atcaagcgct cgaatggaaa agaattgtcc 1524061 aggagcagta ccggatgaag ctgaccgact ttttagatcc ccgagagcag gtcatcctct 1524121 ctgctgttac gggacaggca gatgtcgggc ttgccttttc cggcggctat gacagagcgg 1524181 agcggaaacg ggcgattctg tttccagagt acattactcc ggaagaatca gattttgaac 1524241 tgcaggcgtt taacgtccgt tatgctgaca agtttgtctc agtagatcat cgttctctgc 1524301 ttggtgcatt aatgggcata ggattaaagc ggcaaaaatt cggtgacatc gtgttttctg 1524361 agacagcagt gcaattgatt gtctcagccg ataccgctga ttttgtggct gcacagctga 1524421 cccaagcagg caaagcggcg gtcagcctag agaaaatcga cttgtcagac cttaacattc 1524481 cagcagttga tgtcgaaata agagatgaca cggtttcttc tttaaggctt gacgccgtct 1524541 gcgcctctat gagcaggcaa tcccgccaga aatcacagac gcttgtgaaa aacggccttg 1524601 tgaaagtgaa ctggaaggtg gttgaagatc cttcatacat agtcgcggaa ggggacatgc 1524661 tgtctatcag aggttttggc cggtgcagct taacaaaaat cgaaggaaaa accaaaaaag 1524721 acaaatggag agttacgttt gaacgacaaa aatagtcggt ttttcagttt ttttctccat 1524781 ctgtgcgaaa tttgttttat aatgtgaact agataaccgt actgaaatgt aaaaatggag 1524841 gtggcatcat gccattaacg ccaaatgata ttcacaacaa gacgtttaca aaaagttttc 1524901 gcggatatga tgaagatgaa gtaaatgaat tcctagccca agtcagaaaa gattacgaaa 1524961 ttgttctccg caagaaaact gagcttgaag cgaaagtcaa tgagcttgat gaaagaatcg 1525021 gacactttgc caatattgag gagacattga ataaatcaat tttagttgct caagaagcgg 1525081 ctgaagacgt aaaacgcaat tctcaaaaag aagcaaagct gatcgttcgg gaagcggaga 1525141 aaaacgctga tcgcattatc aacgaatcgt tatcaaaatc aagaaaaatt gcaatggaaa 1525201 ttgaagagct gaaaaaacag tctaaagtgt tcagaacacg tttccaaatg ctgattgaag 1525261 ctcagcttga tcttctgaaa aatgacgatt gggatcatct ccttgagtat gaagtcgacg 1525321 ctgtatttga ggaaaaggaa taaattctct gattatcttg acattttctt agcttgtcga 1525381 atataatacg ttcataaatt cagatgaaaa aacggttgaa agggacagtc atgtttcctt 1525441 caggccttca tagcgacccg gagatggtga gagtccggga tggccggaat catgtagatc 1525501 agccctttag tttccttgct gaactcacag taggttagga cgttcatcac gttacgatgc 1525561 tcaagaggaa aaagtgtatg cttgcttttt ctaaaagggt ggtaccgcga gataagcttt 1525621 ctcgtccctt atgggatgag agggcttttt ttattttctg aaaaaatgca gtggaggaat 1525681 gaaaatggat tttaaagaca cgctcttaat gccgaaaaca gatttcccga tgcgtggaaa 1525741 tttgccaaac cgtgagcctg acattcaaaa aaaatgggag gaagaagata tctaccgtct 1525801 tgttcaggaa cggacgaaag accgcccgaa atttgtttta catgacggac ctccgtatgc 1525861 aaacggcgac atccatatgg gccatgcact taacaagatt ttgaaagact tcattgtccg 1525921 ctataaatca atgagcggct acaacgcacc gtatgtgccg ggctgggata cacacggatt 1525981 gccaattgaa acagctctga caaaaaacaa aaaggtcaac cgcaaagaaa tgtcagtagc 1526041 ggaattccgc aaactatgcg aagagtacgc ttggaagcaa atcgagggac agcgtgagca 1526101 attcaaacgt cttggtgtcc gcggtgactg ggaaaaccca tatgtgacat taaaaccgga 1526161 atacgaagcg cagcaaatcc gcgtatttgg tgaaatggca aaacgaggct acatttacaa 1526221 aggccttaaa ccggttaact ggtcaccttc aagtgagtct gctctggctg aagccgagat 1526281 cgaatatcaa gataaacgtt cagcatctat ttacgtcgct tttggtgtaa aagacggaaa 1526341 aggcgttctt gaaaacggcg agcgcatcat catttggaca acaacgccgt ggacaattcc 1526401 ggcgaacctc ggaatctcag tgcaccctga tcttgagtac agcgtgattg cagtaggtga 1526461 agaccgcttt gttgtagcaa gtgccttagt cgaaaatgtt gcatcggcat gcggatttga 1526521 tcagtatgaa gtgacaagaa cggtcaaagg gaaagacctt gagaacatta tcgctgaaca 1526581 cccgctatat ggcagagact ctctcgttat gcttggtgaa cacgtaacaa ctgatgccgg 1526641 aacaggctgt gttcatacag cgcctggaca tggggaagat gactttatca tcggccaaaa 1526701 atacggttta gatgtgcttt gcccggtcga tgaaaaaggt gtaatgacaa gcgaagctcc 1526761 tggctttgaa ggcatgttct atgatgatgc aaacaaagcg atcacacagc agcttgatga 1526821 aaaaggcgca cttgtgaagc ttgaattcat tactcattct tatccgcatg attggagaac 1526881 aaaaaaacca accattttca gagcaacagc gcaatggttt gcgtctatta aagatttcag 1526941 atcagacctg ctggatgcca ttaaagaaac caaatgggtt cctgaatggg gcgagcagcg 1527001 tttgcacaac atggttcggg accgcggaga ctggtgtatt tccagacagc gtgcgtgggg 1527061 tgtgccgatt ccggtatttt acgctgaaaa cggagaaccg gttattacag atgaaaccat 1527121 tgaacatgtt tctgaattgt tcagacagca tggatcaaac atttggtttg aaaaagaagc 1527181 aaaggatctt cttccggaag gctttacgca tcctggcagc ccgaacggca catttacaaa 1527241 agaacaggat atcatggatg tttggtttga ttcaggctct tcacatcaag cagtgcttga 1527301 agaacgtgat gacctcgttc gcccggctga tctataccta gagggatctg accaatatcg 1527361 cggctggttt aactcttctc tttctacagc agtagccgta acagggaaag cgccgtataa 1527421 aggtgtgctc agccatgggt tcgcactgga tggagaagga cgtaagatga gtaaatcaat 1527481 cggtaacgtt gttgttccgg ctaaagtcat gaaacagctt ggtgccgaca tcttaagatt 1527541 atgggtatct tcagtggatt atcaggcgga cgttcgcgtg tctgacgcca ttctgaagca 1527601 ggttgcggaa gtatatcgta aaatccgcaa cacgttccgt ttccttcacg gcaacctttt 1527661 cgattttgat ccaaaaacaa atgcggtggc tgtcgaagat cttcgcgaag tggatcagta 1527721 tatgctgatt aagctgaaca agctgattga taaagtgaaa aaagcgtatg atgagtacga 1527781 atttgcggtt gtgtatcaca gcattcataa tttctgcaca atcgaattga gctcattcta 1527841 ccttgatttt gcaaaagata ttgtctacat cgagcatgcg gatcatccgg atagacgcag 1527901 catgcagaca gtattctacg aaacgcttct tgcattagtg aagctttcag cgcctatcct 1527961 tccacatacg gcagacgaat tgtggtctca tttaacattt gttgaagagc agagcgttca 1528021 gttgaccgat atgccggaaa caatcacggt tccaaacagt gaagcgactg aagaaaaatt 1528081 tgaccgcttt atggctcttc gtgatgacgt gttaaaagca ttagaaactg cgcgaaatga 1528141 aaaaattatc ggtaaatctt tggaagcaaa cctgaaattg tatccaaaca aagaaaacaa 1528201 ggagctcttg gcttccataa aagaaaacct ttctcagctg tttattgtgt ctgaactgac 1528261 aatcagcgaa gaaaatgaag cgccgaacga tgcgcaaagc tttgcgacgg gtaaaatcgc 1528321 tgtcgagaaa gcggaaggcg aaatgtgtga gagatctcgt gtgatttcaa aagatgtagg 1528381 ggcaaatccg aaatatccta cactttcatt acgcaacgct gaaatcgttg aaaaatacta 1528441 tcaaaaataa tgcaaaagag cccggcgtaa aagccgggct ttttttgtgc caagagtgac 1528501 atcctttaga acgaaaggaa aaatcttatg ggctttagat catcattcac aggcaacaat 1528561 aaagatacta cgttaagagc aggagttgtg aagaatgaat gatcaactga ccgcaattta 1528621 tacggaactt cttctgatga aagaagaatt acagtcgaga ttatttgagt attcttgctt 1528681 tcaggtttct acaagcccgc aagcagcaat caatcaaaaa caaaaagcaa ctctgatcta 1528741 tcatattaaa gaagaacttc aagacgttct ccttgcattg tccaaaatcg aaaacggcac 1528801 attcggatac tgtgaagaaa ctggggcccc cattcctctt gcaaagctgg cagtgctgcc 1528861 gacggcccga acagcaaacg attttcttta ttctgtccaa tttgagaaaa aaacgcttcc 1528921 gatatggaaa tcaacggata tcgaatatgg tcaggcactg tatgaataac agtgtctgtc 1528981 cggttaatat gcctgatatt tctttactcc agtgcttttt attgataaaa tgcataatgg 1529041 attaaagtaa ccgtaaactg gaggaacgtt tgtgctgtat tatatgattg cactacttat 1529101 tattgcagcc gatcaattga caaaatggct agttgttaag aacatggaac ttggccaaag 1529161 cattccgatc attgatcagg tattctatat cacctcccat cgcaatacgg gtgctgcatg 1529221 ggggatatta gcgggtcaaa tgtggttttt ctacctcata acaaccgctg ttattattgg 1529281 tattgtttat tacatacagc gttatacaaa gggacaaagg cttcttggcg ttgccctcgg 1529341 acttatgctt ggcggtgcca tcggcaactt tatcgatcgg gctgtcagac aggaagttgt 1529401 ggattttatc catgttatta ttgtcaatta caattacccg atatttaaca tcgcggactc 1529461 ttcactatgt gtcggcgtaa tgcttttatt tatacaaatg ctgttggaca gcgggaaaaa 1529521 gaaaaaggag caatagcatg aatcaaattg atataaccgc ttcagaagaa caaaaaagtg 1529581 agcggattga taaatttttg gcatcgactg agaatgattg gtcaagaacc caggttcagc 1529641 aatgggtaaa agacggacag gttgtcgtga acggaagcgc ggtgaaagcg aattataaaa 1529701 ttcagccggg tgatcaggtg accgtcactg tacctgaacc ggaagcgctc gacgtcctgg 1529761 cagagcctat ggatctggat atttattatg aggaccagga tgtgctggtc gtcaacaaac 1529821 ctcgcggaat ggttgttcac ccagcacccg ggcatcttac gggcacactt gtaaacggtc 1529881 ttatggctca ttgcacagac ctttccggaa taaatggtgt gatgcgcccg ggtattgttc 1529941 acagaatcga taaggacacg tccggtttat taatggtggc gaaaaatgat atggcgcacg 1530001 agtcactcgt aaaccaattg gtcaacaaaa cggtcacgcg gaaatatacg gcggttgtcc 1530061 acgggcttat ttctcatgat gacggcacaa ttgacgcgcc gatcggacgg gataaaaaag 1530121 accgtcaaag catgactgtg acacgtgatg gcaaaaacgc tgtcactcat tttcatgtgc 1530181 ttgagcgttt tcaggatttt acgttagtgg agtgccagct tgaaacaggg agaacccatc 1530241 aaattcgtgt tcatatgaaa tatatcggat tcccattagc aggcgatccg aaatacggcc 1530301 caagaaaaac aatcgacttt aatggccaag cgcttcacgc gggagtttta ggttttgacc 1530361 atccacgaac aggagaatat gtcgaatttg aagcgccgct tcccgaggat atggcagaat 1530421 taatcgaaaa cctcagaaaa aacggttgac agagggtttc ttttctgaaa taataaacga 1530481 agctgaatag attctttaaa acagtccaga gaggctgaga aggataacgg atagacggga 1530541 tgcgtgtata ggcgcgcacc ttgtcctaaa acccctctat gctctggcag gaggggtttt 1530601 ttcttctata tgaactgtga ggtgtcacac attgaatcaa aaagctgtca ttctcgacga 1530661 acaggcaatt agacgggcgc tgaccaggat tgctcacgaa atgatcgaac gcaataaagg 1530721 aatgaataac tgcattcttg tcggcattaa gacaagaggg atttacctgg caaaacgcct 1530781 tgcggaacgc attgaacaga ttgagggaaa tcctgttaca gtcggtgaaa ttgatattac 1530841 tctttacaga gatgatcttt ctaaaaaaac aagcaacgat gaaccgcttg taaaaggtgc 1530901 agatattccg gtagatatta cagatcaaaa agtcattctc gttgatgatg ttctgtatac 1530961 cggaagaaca gtcagagcag gaatggatgc gcttgttgat gtaggcagac cttcctccat 1531021 tcagcttgca gtgcttgtgg acagaggaca ccgggagctg ccgatccgag cggattatat 1531081 cgggaaaaac atcccgacat caaagtctga aaaggttatg gtacagcttg atgaggtaga 1531141 ccaaaacgat ctcgtcgcca tttatgaaaa cgaataatag atcacctttt taagggcaat 1531201 ccagagaggt tgcaaagagg tgcacaacaa aggcccaaaa agtattcggc aggtctttgt 1531261 atgcctcttt gcgtaaaaaa gcaaagaggt ttttttatac agtcattgag tcatcctaaa 1531321 atgaaagtca acaatcaggg ggaaatcatc atgagtaaga aaaaagtaaa tttaggggtc 1531381 agggatgtcc cgacaccttt ctcttgggtt tcattcagcc ttcagcattt gtttgccatg 1531441 tttggctcaa ccattttggt tccgaagctc gtcggaatga gtcctgctgt ggcgttggtg 1531501 acaagcggca tcggaacact ggcgtacctt cttattacca aaggacaaat tccggcgtat 1531561 ctcggttcat ccttcgcctt tatttctccg atcattctgg taaaagcgac cggcgggccg 1531621 ggagcggcaa tggttggagc gtttcttgca gggctggtgt acgggctgat tgccttattg 1531681 attaggcagc ttggaacagg atggctgatg aagattctcc cgcctgtagt cgtagggcct 1531741 gttattatcg tcatcgggct gggactggca agcactgcag taaacatggc gatgtatgct 1531801 gatccgaacg cgagtgagtt ggtctacagc ttaaagcact ttagtgtcgc aggagttacg 1531861 ctggcaatta cgattatttg tgcgattttc ttacgagggt ttttaagcct gattccggtt 1531921 ctgatcggaa tcatcggcgg atacctgttt gcccttactc aagggattgt caacttccag 1531981 ccggtgcttg acgcgaaatg gtttgcagtg cctgaattta tcattccgtt caaagattat 1532041 tcaccgtcag ttacgctcgg catcgcagcc gcaatggttc ctgtcgcatt tgtcacaatg 1532101 tcagagcata tcggccacca aatggtgctg agcaaggttg tcggacaaga cttcattaaa 1532161 aagccaggtc ttcatcgctc tattatgggt gacagtgtgg cgacaatcct cgcttccctg 1532221 atcggcggcc ctccgacaac gacttacgga gaaaacattg gcgtgctggc catcacaaga 1532281 gtattcagcg tctttgtcat cgggggcgcg gcagtgattg ccctttgctt cggctttatc 1532341 ggcaaaattt cagcgctgat cagttcagtg ccgtcagcgg tcatgggagg cgtctccttc 1532401 ctgctgttcg gaatcattgc ttcaagcggc ctgagaatgc tgattgacaa caaaattgat 1532461 tatgaaaaca acagaaacct cattattaca tcagttatcc ttgtcatcgg tgtaggaggc 1532521 gcttttatcc aagtgtctca gggcggattc caagtgtcag gaatggcgct tgccgcaatt 1532581 gtcggtgtca tcttaaacct gattcttccg caggcgaagg aagagcaggc agacacatct 1532641 gaacaacatc atatttaaaa ccttttaatg aaagtccaga gaggcttgga agggttatga 1532701 agagaaggaa gcttcaatgc tgccctctat ttaaccatac cccgagtcta tcttagaccg 1532761 gggttttttt tcagccttaa gttgaaaaga gaggggaaag aacatgaagc atttaacgac 1532821 gatgagtgaa cttagcactg aggaaatcaa agatttgctt caaacagcac aagagctcaa 1532881 aagcggaaaa acagacaatc agcttacagg aaagtttgca gcaaacctgt ttttcgaacc 1532941 gagcacgaga acgcggttca gctttgaggt cgcagaaaaa aagctgggca tgaatgtgct 1533001 taaccttgat ggaacaagca caagcgtgca aaaaggcgaa accttatatg acacgatccg 1533061 gacgcttgaa tcaatcggtg tggacgtctg cgtcatcagg cacagtgagg atgagtatta 1533121 tgaagagctt gtcagccagg tgaacattcc gattctgaat gcgggagacg ggtgcggcca 1533181 gcatccaaca caatcactgc ttgatttaat gacgatttat gaagagttca atacgtttaa 1533241 agggcttacc gtctccattc acggcgacat caagcatagc agagtggcaa ggtcaaatgc 1533301 ggaagtgttg acaagattgg gtgcccgggt cctattttcc ggcccttcgg aatggcagga 1533361 tgaagaaaat acattcggca cgtatgtctc aatggatgaa gcagttgagt cttccgatgt 1533421 tgtcatgctg ctgcgcattc aaaatgaacg acatcagtcc gctgtcagtc aggaaggcta 1533481 tttaaacaaa tacggcttga ccgtagaacg ggctgagcgt atgaagcggc atgcgatcat 1533541 catgcatcct gctccggtaa acagaggagt ggagattgat gacagcttag tagaaagcga 1533601 aaaatcaaga atcttcaagc aaatgaaaaa tggcgtattt atcagaatgg cagtgataca 1533661 gcgtgcctta caaaccaatg tgaaaagagg agaagcagcg tatgtcatat ctcattaaaa 1533721 acggctggat actaaacgaa aatggtgaaa aaacacaagc ggatatccga gtgactggag 1533781 aaaccatcac cgcaatcggc aagcttgatg caacggataa tgaaacggta attgatgcaa 1533841 aaggtttgct cgtttcacct gggtttgttg atctccacgt gcatttcaga gagccgggcg 1533901 gagagaaaaa agaaactatt gaaaccgggg caaaagcagc ggcgcgcggc ggctatacta 1533961 cagtagcagc aatgccgaat acgcggccgg ttcctgatac aaaggagcag atggaatggg 1534021 tgcaaaacag aattaaagaa acatcatgcg taagagttct tccatatgca tccattacga 1534081 tcagacaaat cggcgatgaa atgacaaact ttgaagcgtt aaaagaagcc ggggcatttg 1534141 cttttacaga tgacggcgtt ggtatacaga cagcaggaat gatgtatgaa gcgatgaaac 1534201 gggcagccgc aattgacaaa gcgattgttg cacattgcga ggacaactcc ttaatttacg 1534261 gagggagcgt acatgagggg acattctcca aagcgaacgg gctaaacggc attccttctg 1534321 tgtgtgaatc ggttcatatt gctcgcgatg tgctgctggc tgaggcggca aactgccatt 1534381 atcatgtatg ccatatcagc acaaaagaat ctgtcagagt tgtacgcgat gcgaaaaaag 1534441 cgggaatcag agtgacagca gaagtatcgc cgcatcattt gctgctttgt gatgaggaca 1534501 tcccggggct ggacacaaac tataaaatga atcctccgct ccgcagccca gaagacagag 1534561 ctgctttaat tgaaggtctt ttagacggaa caattgattt tatcgcaaca gaccatgcac 1534621 cgcatacgga agaagagaag aacacagaaa tgaagctggc gccattcgga attgtcggct 1534681 tagaaacagc attcccgctt ctttacacac actttgtcaa aaatggcagc tggtcactga 1534741 agcagctgat tgactacatg acaatcaagc catgcgaagc gttcggtctc ccatatggaa 1534801 cattacaaac ggggcaagct gcggacatta cgttaatcga tttagaaaaa gaagcagtta 1534861 tagacaaaga gacattttta tcaaaaggaa aaaatacacc attcaacggc atcagttgca 1534921 ccggctggcc ggtcgctaca attgcggcag ggaagcttgc ttatgaagag gggagacttg 1534981 tcaaatgaag agacgattag tactggaaaa cggagcggta ttcgagggag aagctttcgg 1535041 aagcttagaa cacaacatgg gagaagtcgt ttttaatact gggatgacag gctatcagga 1535101 aattttatct gatccttctt actgcggaca gatcgtaaca ttaacatacc cgcttatcgg 1535161 aaattacggc attaaccgtg atgattttga atccattacc ccttttgtca aagggctgat 1535221 catcaaagaa ttatgtgagc tgccttccaa ctggcgttca gcatacacct tagacgagta 1535281 tttaaaaatg aaaaacattc ccggactcca gggaattgat acaaggaagc tgacaagaat 1535341 gatccgcacg gcaggcgcgc taaaaggaac attcgcttca tctgatgaag atatcgaagc 1535401 agtgctgaaa agactgaacg aaacggaatt gccaagaaat caagtatccc aagtatcagc 1535461 aaaaacagca tatccgagcc cgggaagagg caaacgcatt gtcttggttg acttcggcat 1535521 gaaacacggg attctaagag agctgaacaa acggaaatgt gacgtcatcg ttgtgcctta 1535581 caacattaca gcggaagagg tgcttcagct gaaaccggac ggtatcatgc tttctaacgg 1535641 acctggagac ccgaaggatg tgcctgaagc gattgaaatg attaaaggtg ttcttggaaa 1535701 agtgccatta ttcggaatat gtctcggcca ccaattattc gcgctggcgt gcggggcgaa 1535761 tactgaaaaa atgaaattcg gccacagggg ctcaaaccac ccggtaaaag agctggctac 1535821 aggaaaagtt gccttaacat ctcaaaacca tggatataca gtttcgtcta tcagtaaaac 1535881 agaactggaa gtgacgcata tcgcaattaa cgacgatacg attgaagggc tgaagcataa 1535941 aacattgccg gcatttacgg ttcaatatca tcccgaagcc tcacctggtc ctgaggatgc 1536001 caaccatcta tttgacagat tcatcgaaat gatcgaaaca acagagaaag aaggggaagc 1536061 ggtatgccaa aacgcgtaga cattaacaaa attttagtaa tcggatctgg accgatcatc 1536121 atcggccaag cagcagaatt tgactatgcg ggaacacaag cctgtcttgc tttgaaagaa 1536181 gaaggctatg aagtcatcct tgtcaactca aaccctgcaa cgatcatgac agatacagaa 1536241 atggctgacc gggtttacat cgaaccgctc acacctgaat tcctgacacg aatcatcaga 1536301 aaagagcgcc cggatgccat tcttcctaca ctcggaggcc aaaccggttt gaatcttgcg 1536361 gttgagcttt ctgaaagagg cgttttggca gaatgcggcg tcgaagtgct tggcacgaaa 1536421 ctgtctgcga ttcagcaagc tgaagaccgt gacttgttca gaacattaat gaatgaactg 1536481 aatgaaccgg tgcctgaaag tgagattatc cactcccttg aagaagcaga aaaattcgtc 1536541 agtcaaattg gattccctgt cattgtccgc ccggcatata cattaggcgg aacaggcgga 1536601 ggcatctgct cgaatgaaac agagctaaaa gaaatcgttg agaacggctt gaaattaagc 1536661 ccggtacacc aatgtctgct tgaaaaaagc atcgccggct ataaagaaat cgagtatgaa 1536721 gtcatgagag acagccagga tcacgccatt gtcgtttgta acatggaaaa cattgatcca 1536781 gttggaatcc atactggaga cagtattgtt gtcgcgccga gccaaacgct cagcgatcgc 1536841 gaatatcagc tcttgcggaa tgtatcgtta aaactgattc gcgcgcttgg gatcgaaggc 1536901 ggatgtaatg tccagctcgc cttagatcca gacagcttcc aatattacat tattgaagta 1536961 aatccgcgtg tcagccgttc atctgccctt gcatcaaaag caacggggta cccgattgca 1537021 aagctcgctg ctaaaattgc agtcggactt tcattagatg aaatgatgaa cccggtgaca 1537081 ggaaaaacat atgcagcatt tgaacctgct cttgactatg tcgtatccaa aattccgcgc 1537141 tggccgtttg ataagtttga atcagcaaac agaaagcttg gcacgcaaat gaaagcgaca 1537201 ggtgaggtca tggcaatcgg ccgcacgctt gaagagtcat tgctgaaggc agtgcgatca 1537261 ctggaagcgg atgtgtatca tcttgaattg aaggacgccg ctgacatttc agatgagctt 1537321 cttgaaaagc gaattaaaaa ggccggtgat gaacgcttat tctacttagc tgaagcgtac 1537381 agaagaggct acacggtaga agacctccat gaattttccg ctatcgatgt cttcttcttg 1537441 cataagctgt tcggaatcgt acagtttgaa aaagaattga aggccaatgc gggcgataca 1537501 gatgtgctga gacgggcaaa agaactcggc ttctctgatc agtacatcag ccgtgaatgg 1537561 aaaatgaaag aatctgagct ttacagcttg agaaaacaag cggggattgc gccggtattc 1537621 aaaatggtag atacatgcgc ggcggaattt gagtcagaaa cgccatactt ctatagcaca 1537681 tatgaagaag aaaatgaatc tgtcgttaca gataagaaaa gtgtgatggt gcttggttcg 1537741 ggtccgattc gaatcggtca gggtgtcgag ttcgactatg cgacggttca ctctgtatgg 1537801 gcaattaaac aagcaggcta tgaagccatt attgtcaaca acaacccgga aaccgtttca 1537861 acagacttca gcatctcaga caagctgtat tttgaaccgc ttacgattga agatgtcatg 1537921 cacatcattg acctcgaaca gccaatgggc gttgtcgtac aatttggcgg acaaactgcg 1537981 attaaccttg ctgacgagct ttctgcacgc ggagtgaaaa tccttggaac ttcattagaa 1538041 gatttagacc gtgccgaaga ccgggataaa tttgaacaag cgcttggaga acttggtgtt 1538101 cctcagccgc ttggcaaaac agcgacatca gttaatcagg cggtaagcat cgcaagtgat 1538161 atcggttatc cggtactggt acgcccttcc tatgtacttg gcggccgggc gatggagatt 1538221 gtttaccatg aagaggaact gcttcattac atgaaaaatg cagtcaaaat caatccacag 1538281 caccctgtat taattgatag atacttgacc ggaaaagaaa ttgaagtcga tgcagtatcc 1538341 gacggtgaaa cagtcgtcat tccgggaatt atggagcaca ttgaacgtgc gggcgttcac 1538401 tccggagact caatcgctgt ttatccgcct cagtctctca cagaggacat taagaaaaaa 1538461 attgaacaat acacgatcgc attggctaaa gggctgaata ttgtcggttt gctcaatatt 1538521 caattcgtct tgtcgcaagg cgaggtgtac gtgctagaag tgaatccgag atcaagcaga 1538581 accgtaccgt ttttaagcaa aattacgggt atcccaatgg cgaatctcgc aacaaaaatc 1538641 attcttggtc aaaagctggc tgcgtttggc tatacagagg gccttcagcc tgaacagcaa 1538701 ggtgtatttg taaaagcgcc ggtcttctcc tttgccaagc tgagaagagt ggatattacg 1538761 ttagggcctg aaatgaaatc aacaggtgaa gtcatgggga aagattcgac acttgaaaag 1538821 gcgctctaca aagccttgat cgcttcaggt attcaaatcc cgaactacgg ttccgtgctt 1538881 ttaacagtag ctgataagga caaagaagaa gggcttgcca ttgctaagcg gttccacgcg 1538941 atcggctaca acattttagc gacggaagga acggcaggct acctgaaaga agcttccatt 1539001 ccagcgaagg tcgtcggaaa aatcggtcag gatggcccga acttgcttga tgtcatcaga 1539061 aacggagaag cgcagtttgt catcaatacg ctgacaaaag gaaagcagcc ggcaagagac 1539121 ggttttagaa tcagacgtga atcagtagaa aatggtgttg cctgcctaac atctttagat 1539181 acggcagagg cgatattgcg agtgctggaa agcatgacat tccgtgctga tcaaatgccg 1539241 gcagtcaaca caaatcagga ggcggcagtc actatatgaa aaaagcgtat ttgacagtat 1539301 gttctaacca gcaaattgca gaccgggtgt ttcaaatggt tctgaaaggg gagcttgtcc 1539361 aagggtttac aacccctgga cagttccttc atcttaaagt gagcgaagcg gttacgcctc 1539421 ttttgagaag gccgatcagc atcgcagacg tcaactttga aaaaaatgaa gtcaccatca 1539481 tttatcgggt agatggggaa gggacaagac tcttgtcact gaagcagcag ggagaacttg 1539541 tggatgtcct cgggcctttg ggaaatggct ttcctgttaa tgaagttcaa cccggaaaga 1539601 cggctttgct ggtaggaggc ggagtaggtg tgccgcctct ccaagagctg tcgaaacgct 1539661 tgattgaaaa aggggtaaat gtcatccacg ttttaggatt ccaatcggca aaggatgttt 1539721 tttacgagga agaatgccgg cagtacggag acacgtatgt ggcaacagct gacggaagct 1539781 acggggaaac cggatttgtc acagatgtga ttaaacggaa aaagctagag tttgatatcc 1539841 tcctcagctg cgggccgaca ccgatgctca aggcgttaaa acaggaatat gcccataaag 1539901 aagtatatct gtccatggag gaacgaatgg gctgcggaat cggcgcatgc ttcgcgtgtg 1539961 tgtgccatac aaacgaaagt gagacatcct atgtaaaagt atgtctcgac gggcctgtat 1540021 ttaaagctca ggaggtggcg ctgtaatgct agaggtgaaa ttgccgggac ttgatttgaa 1540081 aaacccaatc attcctgcat caggctgctt cggttttgga aaagaatttt cacgttttta 1540141 tgatttgtct tgtcttggag ctatcatgat taaggctacg acaaaggagc cgcgctttgg 1540201 gaatccgacg ccgcgggtag ctgagactgg tgctggaatg ctcaatgcga tcggtctcca 1540261 aaatccgggg ctggatagtg tgttgcatca tgagctgccg tggcttgagc agtttgatac 1540321 accgatcatt gccaatgtcg caggttctca agtcgatgat tatgttgaag tcgcagaaca 1540381 tatcagcaaa gcgcctaatg ttcatgctct tgaattgaat atttcctgcc cgaatgtgaa 1540441 aacaggcgga atcgcttttg gcacgaatcc tgaaatggct gccgatttga caaaagcggt 1540501 gaaagaggtt tcggatgtac ccgtttatgt gaagctatcc ccgaacgtgg ctaatatcac 1540561 agaaattgca ttagcgatcg aggaagcggg agcggacggt cttacgatga tcaacacact 1540621 aatcggcatg agactcgatt taaaaaccgg caaaccgata ttagcgaata aaacaggggg 1540681 actttcgggc cctgctgtga agccggttgc cattcgcatg gtgtatgaag tcagccagat 1540741 ggtcaacatc ccgattatcg gaatgggagg cgtgcaaacg gctgaagatg ccctggaatt 1540801 tcttctcgcg ggagcaagcg cagtcgctgt cggaacagca aactttgtga atccttttgc 1540861 atgtccagag attattgaac agctcccatc tgttttgctc caatacggct atcaatcaat 1540921 tgaagaatgc atcggaagga gctggaatca tgaaaaacaa cctgcccatc atcgcgcttg 1540981 attttgcgtc agctgaagaa acacttgcgt tcttagcgcc ttttcagcaa gaaccgttat 1541041 ttgtaaaggt tgggatggag cttttttatc aagaagggcc atctatcgtg aaacaactaa 1541101 aagaaagaaa ctgcgagcta tttttagatc taaagcttca tgacatcccg actactgtaa 1541161 acaaagcgat gaagcgcctt gccagtcttg gagtagacct cgtcaatgtt catgctgccg 1541221 ggggcaaaaa aatgatgcag gcagctctcg aaggcttaga agaaggtacg ccggctggaa 1541281 aaaaacgtcc gtcacttatc gcggtaaccc agctgacaag cacatctgaa caaatcatga 1541341 aagatgaact gctgatcgaa aagtctctga ttgatacggt tgtgcactac agcaaacagg 1541401 cggaagaaag cggactggat ggagtggtct gctctgttca tgaagcaaaa gccatttacc 1541461 aagcggtgtc gccttcattt ctgactgtca ctccggggat cagaatgtca gaggacgctg 1541521 cgaatgacca agttcgcgta gcgacgcctg ccattgcaag agagaaaggt tcatcagcga 1541581 ttgtagtagg acgctcgatt acaaaagcgg aagacccggt aaaagcctat aaggctgtca 1541641 gacttgaatg ggagggaatc aaatcttgaa acaaatcatc gcaaaacatc tattagacat 1541701 ccaagctgta tttttacgcc cgaacgagcc gttcacatgg gcaagcggca ttttatcacc 1541761 gatctactgt gacaaccgcc ttacgctatc tttcccagag gtcagaaacg atgttgcttc 1541821 aggtatcagc aagcttgtta aagagcattt tcctgaagct gaaatgattg cgggaacagc 1541881 aactgccggt attcctcatg ctgctcttgc ggcggaccat ttgaatcttc cgatgtgtta 1541941 tgtgaggagc aagccgaagg cgcacggaaa aggcaatcag attgagggag ctgtgcaaga 1542001 agggcaaaaa acagtcgtca ttgaagactt aatttccaca ggaggcagcg tgcttgaagc 1542061 ttgtgcagct ttacaagcgg ccggctgtga agtgcttggt gtcgtctcaa tctttacgta 1542121 cggacttcct aaagcggagg aagccttcgc aaaggcagaa ctgccatact actcattaac 1542181 cgattatgat acgctcacag aggtcgcgct tgaaaacgga aatattcatt cagatgatct 1542241 aaaaaagctg caaacatgga aacgaaatcc cgagtcaaaa gattggttta aaaaataaaa 1542301 aataaattca aatgatgtaa agaggcttca aagccttgct gtacttgaaa acaggctgtg 1542361 aggcctgttt ttttattaat cctataaaaa aagtcgggtt gacttatgtt agaattgtgc 1542421 taaaatttac tacaaatcta aaaacttatc aagagcggct gagggactgg acctatgaag 1542481 cccggcaacc tgcatagttt gtaaggtgct acttccagca aaatgaattc cattttgaaa 1542541 gataagggct gcatgctgtt cctgtctttc tttccgccgg attgaaagtt ttttatttta 1542601 agaggtaaaa aggctatctg tatatcagca gccgcgaatc acattacatg ggaaaagaca 1542661 accggcagaa agctactgtt tgtttgtctc cgaaaggagg aaagaagaaa tgttaacgta 1542721 tgataattgg gaagaaccaa cgattacatt tccggaagac gatccttata aaggagcgct 1542781 gtcagtttta aaatgggcat acggccatta cggcgatcag cttgtttatg cctgcagttt 1542841 cggaattgag ggaatcgttc tgattgactt aatttataaa gtgaaaaaag acgcagagat 1542901 tgtgtttctt gatacaggac ttcattttaa agaaacctat gaaacaattg aacgagtgaa 1542961 agagcgttat ccgggtctta atatcatcct gaaaaaacca gatctcaccc ttgaggaaca 1543021 agccgaagaa catggtgaca aactatggga aagagagccg aatcagtgct gctatcttag 1543081 aaaggtcgtt cctttaagag aggcgctttc aggacatcca gcctggcttt ccggcctgcg 1543141 ccgtgatcaa gggccaagcc gtgccaatac gaatttctta aacaaagatg aaaaattcaa 1543201 gtcagtaaaa gtttgcccgc ttatccattg gacttggaaa gacatttgga gatatacatc 1543261 ccggaatgaa ctggactaca atccgcttca tgaccaaggc tatccaagta ttggctgtgc 1543321 gccttgcact tctcccgctt ttacagcaga agatttgcgc tcaggcagat ggaatggtat 1543381 ggcgaaaaca gaatgcggac tgcatgaata aggagctgca aaatggaatt agccgctatt 1543441 ttatttagct tgtttttcgc gatgaatatt ggtgcaagcg gcgctgcagc ttcgatgggg 1543501 gttgcttacg gctccggagc catcaaaaag aaaacttacg ctttgatcct atgcgcagtc 1543561 ggtgtctttg ccggggcggt cattggcgga ggcgaggttg taaaaacaat cagctccggc 1543621 attattcctg agcagacgat tacactgacg attgtttgca tcattattgg agctgctgcc 1543681 ctgtcgctct ttactgctaa tctgctcggc attcctttgt cgacaagtga agtaacagtc 1543741 ggcgcggttg tcggcgtggg agtggcttat aaagtattgt ttgtgaacaa tcttctgatc 1543801 attgtgtcat tttgggtttt tgtcccgctg ttcgctttcg gcttcaccta tttcgtatct 1543861 aagctgtttc gttattttaa gattgaagta aaatcttcta aaaagcaaaa aatcctcggc 1543921 attgttttgt tagttgccgg atttttcgaa gcattctctg ccggcatgaa taacgtggcg 1543981 aatgctgttg gcccgttagt agctgccggt gtgcttgatg tcggaaaagg aaccttgtat 1544041 ggaggagctt ttgttgctct tggcgcactg ttattaggcc ggcgagtgct agaaacaaac 1544101 gggaagaaaa ttacgaggtt ctccaaaggg gaaggcattc tcttatccgg tacaggagcg 1544161 ggactggtga tcatcagttc tgtatttggg atgccggtgc ccttggcgca agtcacgtca 1544221 tcgtctatta tcggaatagg catggcgaaa aacggtccga acgtgttcca taaacaagtt 1544281 gttcaaacga tgctgaaggt atggatcgta tcgccgtttt tatctttatc gatttcttat 1544341 ctgcttgtat ccttgttttt aaaagcagat tattattcga tctttatcat ggtaagtgtg 1544401 cttttagcgg cgggcggtgc catcagcctg acaaaggcca ttcgtaaaga gagacgctca 1544461 gtccacgaac aaggcggggg aatctgatca ttaatctgag taattttata agttaactag 1544521 gaggagatgg atattatgag cttagcacca cacggaggaa cattagtaaa cagagtagat 1544581 gaatcatatg atgtgagcgg cattcaaaaa gaaattgaac ttgatttaat ttctttcgcg 1544641 gatttggaat tgatcggtat cggtgcatac agcccgattg aaggtttctt taatgaaaaa 1544701 gattacgtat cagtggtcga aaacatgcgt ctttcttccg gcgttgtctg gtctcttcca 1544761 atcacgcttc cggtcgatgc gcaaaaagca gcggaactgt cacttggtga aacggtaaag 1544821 ttaacgtatg aaggagaaac ttacggcgtt atccaaatcg aagacctgta cgtgcctgac 1544881 aaacaaaaag aagctgtcaa tgtgtacaaa acagatgaac aggagcatcc tggtgttaaa 1544941 aagctgttca gccgcggcaa tacatatgtc ggcggaccga ttacgttgat taaaaaagct 1545001 tcaaaacagt tccctgaatt tacatttgaa ccgtcagaaa cgagacgcca gtttgcggaa 1545061 aaaggctggg aaaccattgt cggtttccaa acaagaaacc ctgttcacag agcgcatgaa 1545121 tacattcaaa aaacggctct tgaaacagta gacggcttgt tcttgaatcc gttagtaggt 1545181 gaaacaaaat ctgatgacat tccagctgat gtacggatgg aaagctacca agtgcttctt 1545241 gatcattatt acccgaaaga tcgtgttttc cttggtgtct ttttagcggc gatgcgttat 1545301 gcaggcccga gagaagcaat tttccacgcg cttgtcagaa agaactacgg ctgcacacat 1545361 ttcatcgtcg gccgtgatca tgcaggtgta ggcgactatt acggaacata cgaagcacag 1545421 gaactgtttg acacatttaa acctgaagaa ctcggaatta caccgctgaa atttgagcac 1545481 agcttcttct gtaaaaaatg cggaaatatg ggaacagcaa aaacttgccc tcatggcaga 1545541 gagcatcacg tcattttatc aggcactaag gtaagaggta tgctgagaga cggtgtgctg 1545601 ccgcctgctg aattcagtcg aaaagaagta gtagaagtgt taatcaaagg gatgaagaaa 1545661 aaagaagaag taggcgtatc ttaaggagga ctggcagtga caaatcgcga tattgtatgg 1545721 catgaagcct ctatcacaaa agaagagtat cagcaaaaaa acaagcataa aagctccatt 1545781 ctctggctga cagggttaag cggctcaggc aaatcaacca ttgccaacgc cgctgcgaga 1545841 gaattgtttg agcaaggcta ccaagtcatt gtgctggacg gggataatat ccgtcacggc 1545901 ctaaataggg atcttggttt ttctgatgaa gaccgaaaag aaaacatccg ccggatcgga 1545961 gaggtggcga agctttttgt tcagcaggga accattgtga ttactgcttt tatctctcct 1546021 ttccgcgagg acagacaaca ggttcgcgag cttgtggaag cgggcgaatt taatgaagtc 1546081 tacattaaat gcgaccttga tatttgtgaa caaagagatc cgaaagggct ttacaaaaaa 1546141 gcaagaaacg gcgagattcc gttctttaca ggaattgatt ctccttatga agaaccggaa 1546201 gctccagagc tcgttcttga ttcaggacag catgaccgtg aagcgtgtaa aaatcagctg 1546261 atcgagtttg ttaaacaaaa attgagctga atatgatctg ctgcgttctt ctcagatgcc 1546321 ggaatgcaag cgagaacatc atcacagcga atcttctgga agaactcgaa tagatcgggg 1546381 gaaatacgat ggggaaagta tatattgtag gagcgggtcc cggtgaccct gatctgctga 1546441 caattaaagc gctgaaagcc attgaaaaag ctgatgtcat cttatatgac agattagtaa 1546501 ataaagagat tttacaatat gccaaagagc aagcagacct gatctactgc gggaagcttc 1546561 cggattttca tacgatgaag caggaaacca tcaatcgatt tcttgtgaag tatgcgcaaa 1546621 aagggaaaat ggttgtcaga ctgaaaggcg gagacccttt tgtgttcggg agaggagggg 1546681 aagaagcgga atgcctctct gaaaatggaa ttccgtttga aatcattccc ggcattacgt 1546741 ctggaatcgc ggcagccgct tatgccggga ttcctgttac ccatcgggat gcgggctcta 1546801 acgtcgcttt tgtaacgggt cactataaaa aagaagaaga ttttgaggaa aagtggaaag 1546861 cgctggctac aggaattgat acacttgtca tctatatggg tatcaaaaac gtgcagcaga 1546921 ttgaaagaaa actccttgaa aatggccggg acggttctac gccagcagcc tttattcatt 1546981 gggggacaac ggacaagcaa aaatctgttt tttgtacagt tgacaccctt tcagaaacgg 1547041 tgataaaaga aaacattaca aatccgagtt taattgtcat tggaaatgtt gtaaattatc 1547101 actataagct ggaatggttt gaatctgaac taaaaaaaca agatttaagc gaggcgttgt 1547161 aaaaatgaaa caagcaattt tatatgtcgg ccacggcagc cgggtcaaaa aagcgcagca 1547221 agaagccgca gcctttttgg aaggatgcaa ggcccacatc tctgtgccag tacaagaaat 1547281 cagcttttta gagcttcagg agccgacaat tgagacagga tttgaagcat gtgtgaagca 1547341 aggtgccact catatcgcag tggtgcctct gcttctttta acagctgcgc atgcaaaaca 1547401 tgatattccg gaagaaattg tccgtgttgc atctcgatat ccatcagtcc gtatttcata 1547461 cggaaagccg atcgggattg acgaagaagt agtcaaggct gtatatcacc gaatgaaaga 1547521 cataggtgtt ccgtatgaaa atgccagagt ggtgctcatc ggaaggggaa gttcagatcc 1547581 agacgtcaaa agagacgtaa ccggaattgc taatcttctt caggaaatgg ttccagtgaa 1547641 ggaagtcatt ccgtgctttt tgacagcatg cggccctaat tacaaagagg ttttttcaga 1547701 acttgaaaaa gatgacggca taacaacctt tatcgttcca tatttgcttt ttacgggtat 1547761 gctgatgaat gaaatcgaac gagaggttca gaaattaaaa gcccataatc cgaacgtcta 1547821 cctctcttcc tatatcggtt ttcatcctca tgtgaaaaac gcatttttga accgtgtgag 1547881 agaaactgcg gcaaattctg agggacaatt tgattttgat ggaggttcat atgcttccgc 1547941 tgcacattag cctggaaaag aagaaggttg tgattgcggg gggcggaagc atcgctctca 1548001 gaaggctgaa aacggtgatt tctgagggag ctgatataac gcttgtcagt ccggatgtgg 1548061 aaccggaaat caagcaaatg gcagaagagc ggcgtatcaa atgggaaaaa cggacaattg 1548121 aaaaagaaga ttatctcaat gctttcttca ttattgctgc gacggataat gcggcagtga 1548181 acaaagaaat tgcccaatcc gcttcgcctt ttcagcttgt caattgtgtc agtgacgctg 1548241 agcttggcaa tgtatatatg ccgaaaatcg taaaaagagg gcatgtcact gtgtctgttt 1548301 ctacaagcgg agccagtcca aagcacacga aagagcttgc tgaaaacgtg gataagctga 1548361 ttgacggcga ttttgttgct gaagtgaaca ggctttatca gatgagaaga aagaaataag 1548421 ccagagcata caaatgctct ggcttttctt tatgcggctc agcttttttt gagcttgatg 1548481 acagtatcag catcaggcgt gacaaagacg gtatgctggc tgtcataagt gacgaaaccg 1548541 ggtttcgcgc cgtttggttt tttgacatgc ctgatttttg tataatctac aggcactgaa 1548601 cttgaatctt tagcttttga aaaataagct gcaattgtcg cggcttccat gattgtttgc 1548661 tcatcaggtt cgctgcttct gatcacaacg tgggagccgg gaatgtcctt cgtgtgaagc 1548721 cagatatcgt ctctggccgc cactcttgtc gttaaatatt cattttgacg attgttctta 1548781 cccactaaaa ttgtcagccc tgaggtggat tcatatgttt ctaacaccgg attgtgcggt 1548841 ttttgctttt tctggccttt ttgctgctta gggcgtaaat atttgccctc aacaagctct 1548901 tccctgattt cgctgatatc ccggggagaa gcggacgaaa gctgctgaat cagctgatca 1548961 aaatattcga tctcttcctg tgccagcctg atttgctcct cgacaactgc gaccgaattt 1549021 ttcgctttct gatacttcgt gaaataggcc tgtgcgtttt cagaaggcgt tttgttcggg 1549081 tttaaaggaa tcgtgattgt cgggctttct tcatcataat aattgatgac ctcagcctgt 1549141 ttatcacctt ttttcagcat atataaatta gcggttaaaa gctctccgta aagctgaaat 1549201 tccttcgcgt tttccgaata ctccagggtt ttctctaatt ttttgatttt gttggcattc 1549261 ttcttccgtt cgttcacaac aaaacgctca agatcctgag cctgttgctt aacccggtct 1549321 cgttcagctt ttccgaaata aaaacggtcg agcagttcgc ttaatgaatc aaaacggcgc 1549381 gcttcgccct ttagatgagt cagctccagc agataaaaat attcctttcc gtttacagtc 1549441 gtaatgttgg gaatgaaacg gtgctctttc acttcggcaa acagtgccag caacgctttt 1549501 ggcagtgtga ctttgttggc aaggcctgct ctgtgaaccg cttctttggc gaaaagcgga 1549561 gacacgcctg aaaagtggtc gacaatttgt ttatcaagcc ttccttcttg aaagctgagg 1549621 tgacgcaaaa tatcatcttc tgacgcctca agaggcgata ttttgtcctg agcaggcgga 1549681 agcttataat cttggccggg cagtactgta cggtagctgt tcattgacgg tgataaatgc 1549741 ttaagtccgt cgataatcac attttctgct gcgtcagtca aaatgatatt gctgtggcgg 1549801 cccataattt ctacataaag ctttcgtacg gtttcatcgc caatttcgtt tcggcttttg 1549861 atatgaaaaa tcataatgcg gtctaagccc gcttgttcaa ttttctcaat gaatccgcct 1549921 tcgatatgct ttctcagcaa catgcaaaac attggcggtt cgcttggatt ttcataagct 1549981 tgtgccgtga tatgcacccg tgaatagctc ggatgtgccg ataataatag tttttggttt 1550041 tttcccttgg cacggatgtg gaaaatcaca tcgtgcttat atggctgatg gatttttgta 1550101 attcgtccgc ccattatttt ctcgttaagt tcgtgtgtca ttccgtatgt aaacatgcca 1550161 tcaaacgaca tatgcaatac accctctcat tcttcctgca ttcgataatt atagcatgaa 1550221 atgggacgag tcagaataag catgcttata gagtgatatc tctataagag agcaggggag 1550281 tggacgagcg gaatgaagtt tcatgaaatg ggacaaacag atttactaga ggcaaccaat 1550341 acgtccatga aacaaggatt aacagaaaaa gaggtaaaaa aacgccttga caagcatgga 1550401 ccaaacgagc tgcaagaagg gaaaaaaact tcagcgcttc tcttgttttt cgcgcagttc 1550461 aaagatttta tggtgcttgt gcttctggcg gcaacgttaa tctcaggatt tcttggtgaa 1550521 tatgtagatg cggttgcgat tattgcgatt gtgtttgtga atggcatact cggtttcttt 1550581 caagaaaggc gtgctgagca atctcttcag gctttaaaag agctttcaac accgcacgtc 1550641 atggcactca gggaaggaag ctggacaaag attccttcta aggaactggt gccgggtgat 1550701 attgtgaaat ttacgagcgg ggacagaatt ggcgcagacg ttcgaattgt tgaagcgaga 1550761 agccttgaaa tagaagaatc agcgctaacc ggggaatcaa tcccggttgt gaagcatgct 1550821 gataaattga aaaaaccgga tgtttcactc ggcgatatta ccaatatggc atttatgggt 1550881 acgattgtga cccgcggcag cggtgtcggg gttgtcgtcg ggacaggaat gaatacggct 1550941 atggggaaaa ttgccgacat gcttgaatcg gcagggacat tgtcaacccc gctgcaaaga 1551001 agactggagc agctcgggaa gattttgatt gttgttgcat tgcttctgac cgtacttgtc 1551061 gttgctgtcg gtgttattca gggtcatgat ctgtacagta tgtttttagc aggtgtctcg 1551121 ttagcggtag ccgctattcc ggaggggctg ccggcgattg tgacagtggc gctttcgctt 1551181 ggtgtacaga ggatgattaa acaaaaatcc attgttagaa agcttcctgc tgttgaaacg 1551241 cttgggtgtg cgtctatcat ttgctcagat aaaacaggga caatgaccca aaacaaaatg 1551301 acagtgacgc atgtctggtc cggagggaaa acatggagag tggcaggggc cggctatgaa 1551361 ccgaaaggaa gcttcacact aaacgaaaaa gagatcagtg tcaatgaaca taagccgctt 1551421 cagcagatgc ttctgttcgg agcgctttgt aacaactcca atattgagaa aagagacggc 1551481 gaatatgtgc ttgacggaga tccgacagag ggagcgctgc tcaccgcggc aagaaaaggc 1551541 ggtttttcaa aggagtttgt tgaatctaat tacagagtga ttgaagaatt tccgtttgat 1551601 tccgcacgga aaatgatgac tgtcatcgta gagaatcaag acagaaagcg ctatatcatt 1551661 acaaaaggtg cgccggatgt actcatgcag cgatcttccc gtatttatta tgatggctca 1551721 gcggctcttt tttcaaatga aagaaaagca gaaacagagg cggtattaag acatttggca 1551781 tcacaggcgc tcagaacgat agcggtcgcc tacaggccga taaaagcagg cgaaacaccg 1551841 tcaatggagc aggcggaaaa agatctgacc atgcttggcc tttcaggtat cattgatccc 1551901 ccgcggccgg aagtcagaca ggcgattaaa gaatgccgtg aagcgggaat taagaccgtc 1551961 atgattacag gtgatcatgt agaaaccgct aaagcgatag cgaaagactt gcgcctcctt 1552021 ccgaaaagcg gcaaaatcat ggacggcaag atgctgaatg aactttctca agaagagctt 1552081 tctcatgtgg tggaggatgt gtatgtattt gcccgcgttt cccctgaaca taaactaaaa 1552141 atcgtaaaag cctatcagga gaacgggcat attgtggcga tgacgggaga cggcgtcaat 1552201 gatgctcctg ccattaaaca ggctgatatc ggcgtctcta tgggcattac cgggacagat 1552261 gtggccaaag aagcatcatc tcttgttctc gtggatgata attttgcgac gattaaatca 1552321 gcgataaaag aaggcaggaa catctacgaa aatatcagga agtttatcag atacctgttg 1552381 gcgtctaacg tcggagaaat ccttgtcatg ctgtttgcga tgctgcttgc ccttccttta 1552441 ccgctggttc cgattcagat tttgtgggtc aacttggtga cggacggatt gccggcaatg 1552501 gcgctcggca tggatcagcc ggaaggagac gtcatgaagc gcaagccccg tcatccgaaa 1552561 gaaggggtat ttgcccgcaa gctaggatgg aaggtcgttt ccagaggatt tttaatcgga 1552621 gttgccacta ttttagcgtt tatcattgtg taccaccgca atccggaaaa cttggcttat 1552681 gcccagacga tcgcgtttgc cacattggtg ctcgctcagc ttattcacgt gtttgactgc 1552741 cgcagcgaaa cttctgtttt ctctagaaat ccgtttcaaa acctgtattt aatcggcgcg 1552801 gtattgtcat ccattttgct gatgcttgta gtaatctact atccgccgct tcagccgatt 1552861 ttccatactg tagccatcac gccgggggac tggatgctcg tcatcggtat gtccgccatc 1552921 cctacttttt tgctggcggg gtcactttta acaagaaaaa aataaattca tatgatataa 1552981 tcttaggggt aatagcgtgt ctattgccct tttattatga gaacagggaa gaattgggtg 1553041 ttttaaaatg atacgaagta tgacaggctt cggcagtgca agcaaaacac aagacgatct 1553101 ctctgtaagc gttgaactta aatctgtgaa ctacagattt aaagaagtga acgctcgttt 1553161 gccaaggcct ttgctatatt ttgaagataa gctgaaacag accattctgc agcatattca 1553221 gcgcggaaga attgagcttt tcgtatccgt tgacagcgat atgcttgttg agaaaaggct 1553281 tgaaattgat tggccgctgc tcgatgagtt tgtcgcagcc gcgagagata tgaagaagcg 1553341 gtatcaattg tctgcagagc ccgatgtaat ggatttcttt aagcttgatc atgtcgtcca 1553401 ggttcatgaa gaacagacgc aaaatgacaa gctggaggcg ttgatcatcg atgctgcaga 1553461 agaagcggta aaaggtctct gtgaaatgcg tgaaaaagag gggctgctct tagcgaaaga 1553521 ctgcctgatg catattgatc agcttgaaga gctggtgaga gaaactgaat tgctggctgc 1553581 agatgtcgta tctcgttacc gggaacggct gtatgccaga atcaaagaat ggactgaaga 1553641 cgtattagac gagagccggc ttgtaacaga atgcgctatt tttgcagacc gctctgatat 1553701 cactgaagag attacaaggc tgaagagcca cttcgcccag tttcgtgata tattagctag 1553761 tggcggagct gtcgggcgca aactcgactt tcttgttcag gagctcaatc gggaagcaaa 1553821 tacgatcggc tcaaaagcaa atgatcatca gatcacaaag cttgtcgttg aaatgaaaag 1553881 ttctattgaa aaaataaaag aacaagtgca aaatatagaa tagtgactgt gcgtattgtt 1553941 tacagacggt cttactaggc taaactagag acgtctattt tacaggggga acgtagaaga 1554001 tgacgattaa actgattaat atcggatttg gcaatatcat ctccgccaat cggatgattt 1554061 cgattgtcag cccggagtct gcgccaatca aacggatgat tcaggatgca agagaccgcg 1554121 gaatgctaat tgacgctaca tacggacgaa gaacccgtgc agttgtcgtc atggatagtg 1554181 atcacattat cttatctgcc gtccagcctg agacagttgc acacagactt tctgttaaag 1554241 aagaaattat ggatgaaggg caggggtaat tgccgcatga aagaaagagg gttattaatc 1554301 gttctctcag gtccctcagg agttggtaaa ggaacggttc gacaagcgat cttttcgcag 1554361 gaagacacaa aatttgaata ttcgatttca gtaaccacaa gaagtccaag agagggcgaa 1554421 gtgaacggag tcgattattt tttcaaaaca agagacgaat tcgagcaaat gattgcggac 1554481 aacaagctgc ttgaatgggc agagtatgtc ggcaattatt acggcacgcc agtcgattat 1554541 gttgaacaga cgcttcaaga tggaaaagac gtctttttag aaattgaagt tcaaggggct 1554601 cttcaagtga gaaatgcttt cccggaaggc ctgtttattt tccttgcgcc tccaagcctt 1554661 tctgaactga aaaacagaat cgtgacacga ggaacagaaa cagacgctct gattgaaaat 1554721 cgaatgaaag ccgcaaaagc tgagatcgaa atgatggatg cttatgacta tgtcgttgaa 1554781 aacgataatg tcgaaacggc ttgcgataaa atcaaagcaa tcgttcttgc tgaacatttg 1554841 aagcgtgaac gcgttgcacc aagatataag aaaatgctgg aggttgaata atcaatgtta 1554901 gatccgtcaa ttgattcttt aatgaataaa ttagattcaa aatatacgct ggtgactgtt 1554961 tctgcgagac gtgcccgtga aatgcaaatc aaaaaagacc aaatgattga acatacgatt 1555021 tcacacaaat atgtaggcaa agctttagaa gaaattgatg caggcctgct ttcgtttgaa 1555081 aaggaagacc gcgaatagta gcacaagtag caacctatat catgtaggtt gttatttttt 1555141 tccgtgcggt tttgtaaagt gcagaggggg agaattcatt gcttaacaat cgaaatgtgt 1555201 tactttgcgt gagtggaggc atcgctgttt ataaagcctg tgcgttaacg agcaagctgg 1555261 ttcaggcagg agcaaatgtc aaagtgatta tgactgaatc cgcttgccga ttcgtttcac 1555321 cgctgacatt tcaggcattg agccgccacg aagtctatac agatacattt aaagaacaaa 1555381 atccaagcgt catttctcat attgatgccg cagactgggc cgacttgatt atcgtagcgc 1555441 cggctacggc taatgtgatt ggaaaactgg caaacggcat cgctgatgat atgctgacga 1555501 caacattgtt ggcagcaacg gctcccgttt ggatcgcgcc ggcaatgaac gttcatatgt 1555561 atgaccaccc ggcagtcaaa cgaaacattt ctgttcttta tcaggacggt tattgtttta 1555621 ttgagccaag tgagggctat ttagcatgcg gttacgtagg aaaaggcaga ttggaagagc 1555681 cggaaaacat cgtaaagctg gccgaaaaac attttgctga agaaacatcc gctcctttag 1555741 aaggcaagca tgtggtcatt acagccggcc caacgcggga agcgattgat cctgtccggt 1555801 tttttaccaa taaatcgacg ggcaaaatgg gctacgcact ggcggaggct gctgttcagc 1555861 tcggcgcacg ggtaatctta atttctgggc ctgtttcact tgatcagcct aaaggccttg 1555921 ctgagtttat ccctgttcaa tcggctgcgg atatgcgcga agctgtgctc tctgtgtatg 1555981 acgcaagcga tatagtcatt aaaacagctg cggtagccga ttttacgccg aaaacagtat 1556041 ttgaccataa aatgaaaaaa caagacggcg gcatgacctt agaactgaaa agaacagtcg 1556101 atattttgaa agaattgggc gagaaaaaga aagagcagat tttggtcgga tttgccgccg 1556161 aaacacaaga cattgaacac tatgcacgta aaaagctcgc cgctaaaaac cttgatttga 1556221 ttgtggcaaa tgatgtgaaa gcaaatgggg ccggttttgg tgctgatacg aatatcgtga 1556281 caatcttttt caaagacggg cataaacgcg aactcccgat tatgtctaag ctcgatgttt 1556341 cttttgaaat ccttcaggag atcgcagccc tctcaaaaca aaccggagag cgctcatgaa 1556401 ttttgcagaa gtcatcgttg atgtcagcac caaaaatata gacaggcctt ttgattataa 1556461 aatcccagac catctgaagg gcatgatcaa aacggggatg cgggtcattg ttccgtttgg 1556521 cccccgtaag attcaagggt ttgtgacagc agtcaaagaa gcatctgacc tatcgggaaa 1556581 atctgtcaag gaagtagagg atttattaga tcttacacct gttctgacag aggagcttat 1556641 gattctgtca tcatggctgt cagacaaaac gctgtctttt aaaataacgg cgcttcaagc 1556701 aatgctgcct gccgccttaa aggcgaaata tgaaaaagaa ttaaaaattg cacacggagc 1556761 cgatcttccg ccgcaagtgg aacggctgtt ttctgaaaca aagacgctgc tgtattcaga 1556821 tatacccgat catgagacgc tgaaactgat tcaaaggcat gttcaaaaag gggacattga 1556881 cgtgacgtat aaagtcgcgc aaaaaaccaa taaaaaaatg gtcaggcata ttcaggcaaa 1556941 tgcgagtaaa gaagagcttg ctaagcaggc tgagggattg tcccgccaag cagcaaaaca 1557001 gcaggcgatt cttcactttc tcatctctga gccggaaggt gtgaaaattc ctgcggcgga 1557061 attgtgcaaa aaaacggaca cgagctctgc aaccatcaaa acccttatcc aaaaagggct 1557121 tttgaaggaa agctatgaag aggtttacag agatccctat caggacaaaa tgttcaaaaa 1557181 aacagagccc ctgccgctga cagacgaaca gagggctgcc ttcgagccca tacgcgagac 1557241 attggacagc gatgagcata aagtgttcct ccttcacggc gtgacaggaa gcggaaaaac 1557301 cgaaatttat ctgcaatcaa ttgaaaaagt actggcgaaa ggaaaagaag ccatcgtcct 1557361 cgtaccggaa atatcgctga cgccgcaaat ggtcaaccgc ttcaagggcc gcttcggctc 1557421 ccaggtggca gtcatgcaca gcggtttatc cacaggagaa aaatatgacg agtggcgtaa 1557481 aatccaccgg aaggaagtac ggcttgtcgt cggtgccaga tccgccattt ttgctccgtt 1557541 tgaaaatctc ggaatgataa tcatcgatga agagcacgag tcttcctata aacaggaaga 1557601 aatgccgcgc tatcatgcga aagaggtggc aatcaagcgg gctgagcatc acagctgccc 1557661 ggttgtatta gggagtgcta cgccgacatt agaatcatat gctagagcgc aaaagggcgt 1557721 atacgagctt ctttcactga agcaccgtgt taaccatcgg gtgatgcccg aggtttcgct 1557781 tgtcgatatg agagaggagc ttagaaacgg caatcgctcg atgttttcag ttgaattgat 1557841 ggaaaagctt gaagaaacga ttgccaaggg tgagcaggcg gtgctgtttt taaataagag 1557901 gggctactct tcctttgtga tgtgcaggga ttgcggctat gtcccgcaat gcccgcactg 1557961 cgacatttcc atgacgtatc atcgttacgg ccaaaggctg aaatgccatt attgcggaca 1558021 tgaagagcct gttccgcaca cttgtcctga atgcgcaagc gagcatatcc gctttttcgg 1558081 aacgggaaca cagcgagtgg aggaagagct gacaaaagtg ctgccaagtg cgagagtgat 1558141 tcggatggat gttgacacga catcacggaa aggcgcccat gaaaaattac tgtcagcttt 1558201 cggagaagga aaagcggata ttcttctcgg aacgcaaatg atcgcgaaag ggcttgattt 1558261 tccgaatgtc acgcttgtcg gagtgttaag tgctgataca acacttcata ttcctgattt 1558321 cagatcggct gaaaaaacat ttcagctgtt aacgcaagtc agcggccggg caggcaggca 1558381 tgaaaagccc ggccatgtca tcattcaaac gtatacaccg tctcattaca gtatccagct 1558441 gacgaaaaca cacgattatg aaacgttcta tcagcatgaa atggcgcaca ggagagagca 1558501 atcctatccg ccatactact atttggctct tgtgactgtt tctcatgagg aagtggcgaa 1558561 agcagcggtt acagctgaaa aaatcgctca ttttttgaaa gcaaactgcg gagctgacac 1558621 gaaaattctc ggaccaagcg cgtcgccgat agccaggatc aaagatagat atcgctatca 1558681 atgcgtgata aaatacaaac aggaaaccca gttatccgct ttattgaaga agatactgga 1558741 acattataaa cgcgaaattg aacaaaaaca tgtaatgatt tcaattgata tgaatcctta 1558801 tatgatgatg taagatctca cgtcttggag ggtaacaaat tggcagtaaa aaaggtcgtc 1558861 acacatcctg cggaggtttt ggaaacacct gcggaaaccg tgactgtttt tgataaaaag 1558921 ctaaaaaaac tgcttgatga tatgtacgac accatgcttg aaatggatgg tgtcggactg 1558981 gcagcgccgc aaatcggcat tttaaaaaga gcggccgtcg tagaaatcgg ggatgacaga 1559041 gggagaattg atctcgttaa tcctgaaatt ttagaaaaaa gcggcgagca aaccggaatt 1559101 gaaggatgct tgagctttcc taacgtctat ggtgatgtca cacgtgccga ttatgtcaaa 1559161 gtgcgtgcgt ttaaccgtca gggaaaaccg ttcattctgg aagcgcgagg ctttttagca 1559221 agagccgtgc agcatgaaat ggaccactta gacggtgtgc tgtttacatc taaaataagt 1559281 aaatactata cagaagatga actagcggat atggaaggat gatttgatga cgagaatcgt 1559341 atttatggga acgccggatt tttcagttcc tgttttaaga accctgatag aggacggata 1559401 tgaagtagtg ggggtcgtca cacagccgga ccgtccgaag ggcagaaaaa aagtactgac 1559461 acctcctccg gtaaaggaag aggcattgcg ccacggcatc ccggttcttc agccggaaaa 1559521 agtcagattg acagaagaaa ttgaaaaagt gctggcatta aagcctgacc tgattgtaac 1559581 ggcggcattc ggacaaattt tgcctaaaga gcttctcgac agtccaaaat acggctgcat 1559641 taacgttcac gcatcccttt tgccggaact gcgcggcggt gctccgatcc attattccat 1559701 tctgcaggga aagaagaaaa ccgggattac cattatgtat atggtagaaa aattggatgc 1559761 gggcgatatg atctcaaaag tggaagtgga cattgaagaa accgacaatg tcggaacact 1559821 gcacgataaa ttaagcgttg ctggcgcgaa gctattgtct gaaacggttc caaacgttat 1559881 tgccggcagc atatcacctg aaaagcagga tgaagagaaa gcgacgtacg cgcctaacat 1559941 taaaagagag caagagctgc tcgactggtc cagaacgggc gaagagcttt acaaccagat 1560001 ccgcggctta aatccatggc ctgttgctta tacgactcta aacggacaaa acttgaaaat 1560061 atgggcgtcg aaaaaaatag cggcaccaac aacagctgag cccggcacag tcgttgcagt 1560121 tgaaaaggaa ggaattatcg ttgccacagg taacgagacg gctctgttat taaccgaact 1560181 ccagccggca ggcaaaaaac gaatgaaagg cgaagacttt gtgcgaggcg ctcatgttga 1560241 agccggtgat gtgttaggag taaacaatga aaaaaactag tgttcgtgac atcgcccttg 1560301 aggcgctgat caaattagaa caaaaccagg catacagcaa cctgctgctg aaatcggtca 1560361 ttaaatcaaa tgaactgagt gatcagaaca gagggctttt gactgaactt gtctatggta 1560421 cattacaaaa taagatcgcg cttgattata tgcttaaacc gtttatcaat aagcctcaaa 1560481 aggtaaagcc gtgggtgatt cagcttcttc gcctatcctt atatcaaatg gagtatttgg 1560541 agaagattcc agacagggca gccattcatg aagcggttga gattgctaaa atccgcggac 1560601 acaaaggcat tgcttcattt gtcaacggcg tgctccgttc tattcagcgc gaaggtgttc 1560661 catcctttga cgcgatcgaa gatcctgtcc gccggctggc gacagaaaca agccatccgg 1560721 aatggcttgt gaaagagtgg gcggatgcgt atggatttga agctgcggaa aagatttgcc 1560781 gcatccatct cattccgccg aaacagacgc tgcgtgtcaa tcaaatgaaa gcagacagag 1560841 ctgagctgct tgaccaaatg gctgctgagg gaatcgaagt tgaaaaaggc gacctcgctg 1560901 aagatgctgt gaagctctta aagggaacaa ttgccggaac tcatttcttc caaaacggcg 1560961 aagtttctat ccaggatgag agctccatgc tcgtcgcccg cgcccttgat cctaagtcag 1561021 atgaaacagt gcttgacgcg tgtgcggcgc ctggcggaaa gtcggctcat atcgcagaat 1561081 taatgaagaa caaggggagc gttacgtcgc ttgatcttca caaacataaa gtgaagctga 1561141 tcaaagaagc ggcagatcgg cttggcctga caatcattca tgcggaaaca atggatgcta 1561201 gaaaagcggg ggaaacgttt gaaaacgaac agtttgaccg aatattggtc gatgccccgt 1561261 gctcaggttt cggtgttatc agaagaaagc cggacatgaa atacacgaaa aaacctgacg 1561321 acagcgcccg tctagctgaa atccagctgt cgatcttgag ggaaatcgca ccattagtaa 1561381 aaaaaggtgg cactcttgtc tacagtacgt gtacaatgga ccggacagaa aatgatgaag 1561441 taatacatgc gtttatacaa gaacatcctg attttgaacc cgatttgtct cttgaaaagc 1561501 ggctgcctga aaaggtgaga ccctttgttc gggatggaag gcttcaaatc cttcctcatt 1561561 atttcggaac agatggtttc tttatttgca gcatgagaaa gaagggataa gcaatggcag 1561621 aacttaataa aacaaaagta agaaaagaat tgcggacaga gcgtccgtct atttattctt 1561681 ttgaattaga tgaaatcaaa caatggctga cagacaatgg agagaaaccg ttccgtgcag 1561741 cccagatctt tgaatggcta tatgaaaaac gcgtatcttc ttttgaagat atgacaaacc 1561801 tctcaaagga tctgcgtgag aaattaaaca ctcgctttgt gttaacaacg ctgaaaacgg 1561861 ctgttaaaca aacctctcaa gacggtacga tgaagttttt gtttgagctt catgacggtt 1561921 ataccatcga aaccgtttta atgagacacg agtatggcaa ttctgtatgt gtaacgacac 1561981 aagtcggctg ccgtattggc tgcacattct gcgcgtcaac gcttggaggc ttaaaacgaa 1562041 accttgaagc aggggaaatt gtcgctcaag tagtcaaagt gcaaaaagct cttgatgaaa 1562101 cggatgaacg cgtcagctct gtcgtgatca tgggaatcgg cgaacctttt gataacttta 1562161 acgaaatgct cgctttcttg aaaatcatta accatgacaa gggcctgaat atcggtgctc 1562221 gccatattac ggtctctacg agtggaatca tcccgaaaat ttacgaattt gctgatcagc 1562281 aaatgcagat taactttgca atttctctgc acgcgccgaa cacagaaatc agaagccgtt 1562341 tgatgccgat taacagagca tataaactgc ctgatctaat ggaagccgtt aaatattata 1562401 ttaataaaac aggacgccgt atcagctttg aatacgggct gttcggaggc gtaaacgacc 1562461 aggtggaaca cgccgaagag cttgccgact tgctggaagg agtcaaatgc cacgtgaact 1562521 tgattccggt aaactacgtg cctgaacggg actatgtgcg cacaccgcgt gatcagattt 1562581 ttgcttttga aaaaacgctg aaatcccgcg gagtaaatgt cacaatccga agagagcaag 1562641 gacatgacat tgacgcagcc tgcggtcagc ttcgcgcgaa ggagcgtcaa gacgagacga 1562701 ggtgatgagg gttgttaaca gccttaaaaa cagatacagg aaaaatccgc cagcataatg 1562761 aagatgatgc ggggatattc aaggggaaag atgaatttat attagcggtt gtcgctgatg 1562821 gcatgggcgg ccatcttgct ggagatgttg cgagcaagat ggctgtgaaa gccatggggg 1562881 agaaatggaa tgaagcagag acgattccaa ctgcgccctc ggaatgtgaa aaatggctca 1562941 ttgaacagat tctatcggta aacagcaaaa tatacgatca cgctcaagcc cacgaagaat 1563001 gccaaggcat ggggacgacg attgtatgtg cactttttac ggggaaaacg gtttctgttg 1563061 cccatatcgg agacagcaga tgctatttgc ttcaggacga tgatttcgtt caagtgacag 1563121 aagaccattc gcttgtaaat gaactggttc gcactggaga gatttccaga gaagacgctg 1563181 aacatcatcc gcgaaaaaat gtgttgacga aggcgcttgg aacagaccag ttagtcagta 1563241 ttgacacccg ttcctttgat atagaacccg gagacaaact gcttctatgt tctgacggac 1563301 tgacaaataa agtggaaggc actgagttaa aagacatcct gcaaagcgat tcagctcctc 1563361 aggaaaaagt aaacctgctt gtggacaaag ccaatcagaa tggcggagaa gacaacatta 1563421 cagcagtttt gcttgagctt gctttacaag ttgaagaggg tgaagatcag tgctaatcgg 1563481 caagcggatc agcgggcgtt accaaattct ccgcgtcata ggcggcgggg gaatggccaa 1563541 cgtgtattta gctgaggata tcattctaga ccgtgaagtc gcaattaaaa tcctgcggtt 1563601 tgactatgca aatgacaatg aatttatcag acgtttccgc agagaagccc aatccgcatc 1563661 aagcctcgat cacccgaata ttgtcagcat ttatgatttg ggcgaggaag atgatattta 1563721 ttatattgtc atggaatacg ttgaaggcat gacgcttaaa gaatacataa cagcaaatgg 1563781 gccgcttcac cctaaagaag cgctgaacat catggagcaa attgtctcag ccatcgctca 1563841 tgcccatcaa aaccagattg ttcacagaga catcaagccg cataacattt tgattgatca 1563901 tatgggaaat atcaaagtaa cggattttgg aattgcgacg gcactaagtt cgaccacaat 1563961 cacccatacc aattcagttc tgggctcggt ccattactta tcacctgaac aggcccgggg 1564021 cggcttagcc acaaaaaaat cggatattta tgcgcttgga atcgttctat ttgagctttt 1564081 aaccggccgt attccgtttg atggagagtc agcagtcagc atcgccttga agcatcttca 1564141 agcggaaact ccttcggcaa aaaggtggaa tccatcggtc ccccaaagcg ttgaaaacat 1564201 catactcaag gcaactgcca aagatccttt tcatcgctac gaaacggctg aagacatgga 1564261 agcagacata aaaacagctt ttgatgccga cagactcaat gaaaagagat ttacgattca 1564321 agaagatgaa gaaatgacaa aagcgatacc tatcattaaa gatgaagaac ttgctaaagc 1564381 tgctggcgaa aaagaagctg aagtgacaac cgcacaagaa aacaaaacaa agaagaacgg 1564441 caaaagaaaa aagtggccgt gggttttgct cacgatatgc ctcgttttta tcacagctgg 1564501 aattcttgct gtcactgttt ttccgtcgct tttcatgcct aaggatgtca aaatacctga 1564561 tgtctccgga atggaatacg aaaaagccgc agggctcttg gaaaaagaag gtttacaggt 1564621 tgattccgag gtgttggaaa tctcagatga aaaaattgaa gagggcctga tggtaaaaac 1564681 ggatcctaaa gcggatacca cagtcaaaga aggcgccacg gtcacccttt ataagagcac 1564741 cggaaaagca aaaacggaga tcggtgatgt gacaggccaa acggtcgacc aagcaaaaaa 1564801 agcgttgaag gaccaagggt ttaatcatgt aacagtaaat gaagtgaatg acgagaaaaa 1564861 tgcgggcact gtcattgacc aaaatccttc agcagggact gagctggtcc cgagtgaaga 1564921 tcaagtcaaa cttacagtca gtatcggacc cgaagacatt acgcttagag acttgaaaac 1564981 ctacagtaaa gaagcagcgt ctggatatct ggaagacaac ggattgaagc ttgtagaaaa 1565041 agaagcatac tcagatgatg ttccagaagg acaggttgtc aaacaaaaac cagcagcagg 1565101 tacggcagta aagccgggaa acgaagttga agtgacattc tctctcggac cagagaaaaa 1565161 acctgcgaaa acagtgaaag aaaaggtcaa gatcccctac gaaccagaaa atgaagggga 1565221 cgagcttcaa gtgcaaatcg cggttgacga tgcggatcac agcatctctg acacttacga 1565281 agaatttaag ataaaagagc cgactgaacg aacgatcgaa ctaaagattg aaccaggcca 1565341 aaaagggtac tatcaagtaa tggtaaacaa taaagttgtc agctacaaaa ccattgagta 1565401 tccgaaagat gaataacaag gagggaaaat atgcctgagg gcaaaattat taaggcgcta 1565461 agcggctttt actatgtact ggatgaatca gaggattcag ataaagtaat acaatgcaga 1565521 ggaagaggca ttttcagaaa aaacaaaatt acccctcttg tcggtgatta cgttgtgtat 1565581 caagctgaaa atgacaaaga aggatatcta atggaaatta aagaaagaac caacgagctt 1565641 atcaggccgc caatttgcaa cgttgatcaa gcggtccttg ttttctcagc ggttcagcct 1565701 tctttcagca cggcattgct cgaccgcttc ctggttctcg ttgaggccaa tgatattcag 1565761 ccgattatat gcattactaa aatggatctg attgaagatc aagatacaga agatacgata 1565821 caagcctatg cagaagacta tcggaatatt ggttatgacg tataccttac ctcctctaag 1565881 gaccaagata gtttagcgga catcatcccg cattttcagg ataaaacaac ggtatttgcc 1565941 ggtcagtccg gtgttgggaa atcctcgctt ctcaacgcga tcagtccgga gctcggatta 1566001 agaacaaacg agatttccga gcatttgggc cgcgggaaac acacaacccg ccacgtggag 1566061 ctgattcaca cgtccggagg tttggttgca gatacaccgg gattcagctc gcttgaattt 1566121 acagacattg aggaagaaga gctgggctat accttccctg atatcagaga aaaaagctct 1566181 tcatgcaaat ttagaggctg tttacatctg aaagagccga aatgtgcggt gaaacaagct 1566241 gttgaagacg gggaattaaa gcagtatcgc tatgaccatt atgttgaatt tatgacggag 1566301 attaaagaca gaaagccgag gtattagcat aatgataaag gttgcaccat ctattctttc 1566361 cgctgatttt gccgctttag gcaatgagat taaagatgta gaaaaaggcg gagccgattg 1566421 tattcatatt gatgttatgg acggccattt tgtcccgaat atcacaatcg gtccgctgat 1566481 tgtagaagcg gtccggccgg taacggatct gccgcttgat gtccatttaa tgatagaaga 1566541 gccggatcgt tatatcccgg cttttgcgaa agcaggcgca gatatcctgt ctgtgcatgc 1566601 tgaggcatgt ccgcacctgc accgtaccat ccagctcatt aaagagcaag gagtgaaggc 1566661 cggagtagtt ctaaacccgc atacccctgt acaagtcatc gaacatgttt tcgacgatct 1566721 tgatcttgtt cttttaatga cggtgaaccc gggcttcggc gggcagaaat ttattcattc 1566781 agtccttcct aaaataaaag aggttaagcg aatggcggat gaaaaaggaa aaaaagatct 1566841 gttaattgaa gtagacggcg gcgtcaacaa agaaaccgct ccgctcgtca ttgaagcggg 1566901 cgcaaattta ctcgttgccg gttcagctgt ttatggccag tctgaccgca aaaaagcaat 1566961 ttctgaaatc agaggaagta aataagcagc tttagaaaag agctgggcat acaatagcct 1567021 aagctctttt tcctgtatgc agagaaagga atcagagatg aaaacaatta atatcgttgc 1567081 gggaggcccg aaaaatctca ttcccgatct aaccggctat acggatgaac acacgctttg 1567141 gatcggtgtt gacaaaggca ccgtcactct cttagatgcc gggatcattc ctgttgaagc 1567201 cttcggagat tttgacagca taacggagca agaacgccgg cgaatagaaa aagccgctcc 1567261 cgcccttcat gtgtatcaag cagaaaaaga tcaaacagat ttagacctcg cccttgattg 1567321 ggcgctggaa aagcagccgg atattattca gattttcggc attacaggcg gcagagctga 1567381 tcatttttta ggaaacattc agcttctgta taaaggtgta aaaacgaaca taaaaattag 1567441 gctgatagac aaacaaaatc atattcaaat gttccctcct ggtgaatatg atattgagaa 1567501 ggatgaaaat aagcgatata tctccttcat accgttttcc gaagacatac atgagctgac 1567561 cctgaccggt tttaaatatc ctctaaataa ttgtcatatt acgctcggtt caacactatg 1567621 tattagtaac gaactcattc attcacgagg tactttttcg tttgcaaaag gcatattaat 1567681 aatgataaga agcacggatt aagcatgtgc tttcattcaa ttgctgaaaa caatgaacaa 1567741 ggcggttacg ggacgttata ggaggggaca aaaatgaaat tttacaccat taaattgccg 1567801 aagtttttag gaggaattgt ccgggcgatg ctgggctcat ttagaaaaga ttaatgccca 1567861 ggggttcaaa gccctctttc accacataaa aacgcctgcc acatatcggg gcaggcgttc 1567921 attttgttat acacgctcaa ctttaccgga tttcaaagct cgagcagata catatacttt 1567981 tttaggtttt ccgttcacaa ggatacgaac cttttgaaga ttcgcgcccc aagtgcgctt 1568041 agaagcgttc attgcgtgag aacggttatt cccagctgtt gtttttttac ctgtgataac 1568101 gcatttacgt gccatttgtt tccctcctca cttgcacaaa acatctactt tttaacattc 1568161 atataatctt agatgctttc gatatggata ctttaaataa tttaccacag ctaaaaaacg 1568221 tttgcaacta ttgtttcatc atctttcaag aaaattcact tgacatcttg cggaaacagc 1568281 agcgctatag tatatgtaga ggtacggcca gcgattattg cctggtcttt tcataatgga 1568341 aaccatatag tagaatagct gtaactctat gcattcgaag gaggaactag tgtgtccatt 1568401 gaattaagaa cgaagtacgg acagattgat atatctaatg aagtcatcgc gatggttgca 1568461 ggaggcgcgg cggttgactg ttacggcatt gtcggcatgg cctctaaaaa ccagattaaa 1568521 gacggactga ctgaaatcct tcggaaagag aatttcagca ggggtgtcca agttcgccaa 1568581 gaaggagaac agatacatat cgacatgtat atcattgtca gctacggcac gaaaatttct 1568641 gaagtggcac ataatgtcca aacaaaagta aagtacacag taaatcaaac catcggactg 1568701 gcagtggatt ctgtcaatat ttatgtccaa ggcgtacgag tgacgaaccc gtagttagga 1568761 ggagtaggat tgtctatcag aacattagac ggcagaacct ttgccgagat gattcttgcg 1568821 ggagcgcaga atctgtctca aaacgccagt gcagttgatg cactgaacgt gttcccggtg 1568881 ccggacggtg atacgggaac aaatatgaac ctgtcgatga cttccggagc aagagaagtt 1568941 gaacaaatgg atacggatga tatcgggaag gtgggctccg cgttatctaa agggctgctc 1569001 atgggagcac gcggaaattc aggagttatc ctatcccaat tgttccgcgg atttagcaaa 1569061 aacattgaaa cgaaaaaaga aattaatgca cttgagtttg ccgctgcgct gcaagcaggt 1569121 gtagacatgg cgtataaagc tgtcatgaaa cctgtagagg gcaccatttt aacagttgca 1569181 aaagacgctg caaaaaaagc aatgatctta gcagaaaaag aaaccgatat cactgcgctg 1569241 atgactgcag tgacagaaga agcagaggcg tctttaaacc gcacccctga attgctacct 1569301 gtcctaaagg aagtaggagt tgtcgatagc gggggcaaag gcctgctctg tgtgtatgaa 1569361 ggtttccttg cttcattaaa aggtgaaact gtacctcaga aagcagttct tccgtcactt 1569421 gacgacatgg tcagcgcaga gcatcacaag agcgcgcaaa gcatgatgaa taccgaagat 1569481 attgaatttg gattctgtac cgaagtgatg gttaggcttg atcagacaaa aagagagttc 1569541 gacgaaggca cgttcaggca agacctcagc cagttcggag attctctgct tgtgattgcg 1569601 gatgaatcgc tggcgaaggt tcatattcat gctgaagagc cgggaaacgt gttaaactac 1569661 gcccagcatt acggtgaatt gatcaaaata aaaatagaaa atatgagaga acagcatacc 1569721 tctatcatca gtcaagaaag caaacctgca gacaacgaaa caccgccggc aaaacagccg 1569781 tatggcattg tgactgtagc gatgggagaa ggaattgcag acctatttaa aagcattggc 1569841 gcttctgttg tgattgaagg cggccagacc atgaacccaa gcactgagga tattgttgat 1569901 gccgtgaagt ctgtaaatgc agatacggta tttatcctgc ctaacaactc caacattatc 1569961 atggctgcta accaagcggc cagcgtagtg gatgaacagg tttttgtcat tcctgctaaa 1570021 acggttccgc aagggatgtc agctctgctg gcttttaacc cggatcaaga agctgaagcg 1570081 aacgaggcca atatgctaag cgccattcag caagtaaaaa gcggacaggt gacgttctca 1570141 gtcagagata ctcatattga cggtaaagac attaaaaaag gcgactttat gggcattctg 1570201 aatggaacga ttatcggcac ttctgaaaat cagctgtcag ccgcgaaaat gctgctgtca 1570261 gaaatgatcg gagaagatga tgaaatcgtg accattctat atggtgagga tgcgtctcag 1570321 gaagaagctg agcagcttga agcgtttctc agtgaaaagt acgaggagat tgaggttgag 1570381 atccacaatg ggaaacagcc tctgtattcg tatatagttt cagcagaata gaagggcaat 1570441 ttgcccttct attcttatgt ctgcttttaa gtgcggcagc gctgtaacgc gcccgcttgc 1570501 cattttatat ctgatcaatt agtctagaag caaagcgcta ataagctctg gttcataagg 1570561 aggaatagca tgaaatacag aagcgttttt gatattatcg gcccggttat gatcggtccg 1570621 tccagctctc atacagcggg agctgctaga atcgggagag tggccagaag tttatttggc 1570681 agagagcctg agcgcatcat tgtatctttt tacggctcgt ttgcggaaac gtataagggc 1570741 cacggcacag atgtcgcgat tatcggcgga ttgcttgatt ttgatacatt cgatgaacgg 1570801 attaaaaccg ctatacaaat tgcagaagct aaaggaattg atatagagtt tcgggtagaa 1570861 gacgcagtcc cggtccaccc gaacacagca aaaatcacca tttctgatga aaagggtgag 1570921 ctggaactga cgggtatttc gattggcgga ggaaagattg aaatcacaga attgaatggt 1570981 tttgagctcc ggctgtcagg aaatcatccg gccatattag ttgttcataa tgacaagttt 1571041 ggcacaattg ccggtgttgc caatgttctg gcgaaatttt caatcaacgt aggacatatg 1571101 gaagtagccc ggaaagatat cggccagctt gcgctgatga caatagaggt cgatcaaaat 1571161 attgacgacc acattctcga cgagctgtcg aagctgccga atattattca agtgacaaag 1571221 attgctgact agcgaaaagg gtcaggagga gccagttatg tttcgtaatg taaaagaatt 1571281 aattgagatt actaaagaaa aacaaatatt gatctctgat gtgatgatag ctcaagagat 1571341 ggaagtaaca gaaaaaacaa aagaggacat ttttcagcag atggatcata acctgtctgt 1571401 tatggaagcg gcggttcaga aaggactcga gggagttacg agccaaacgg gcttaacagg 1571461 cggagatgcc gttaaattgc aggcctatat tcgatcagga aaaagcctgt ctggcccgct 1571521 gattttagat gctgtatcga aagccgttgc aacaaatgaa gtaaatgcag ccatgggaac 1571581 catctgtgcg acaccgactg caggttctgc cggtgtggtg cccggtacgt tatttgctgt 1571641 aaaagaaaag ctgaatccaa caagagaaca aatgatccgc tttttgttta cagccggggc 1571701 tttcggattt gtcgtggcca ataacgcaag catttccggc gccgccggag gatgtcaggc 1571761 agaggttgga tcagcttcag gcatggcggc tgcggctatt gttgaaatgg caggaggaac 1571821 acccgaacaa agcgcggaag ccatggccat tacattaaaa aatatgctag gcctcgtgtg 1571881 cgaccctgtt gcagggcttg ttgaggtgcc ttgcgtgaaa cggaatgcga tgggcgcgtc 1571941 aaatgcgatg attgctgctg atatggcatt ggcgggcatt acaagccgta ttccatgtga 1572001 tgaggttatc gatgccatgt ataaaatagg ccaaacgatg ccaactgcac ttagagaaac 1572061 aggccagggc ggtttagcgg caacaccgac aggaagagaa ttagagaaaa aaattttcgg 1572121 aggagcgcta ggttcacgtg aaacaacatc agcaaactag tatagctaac attaagggta 1572181 ttgggccgga aacagaaaaa acattgaatg aactcggtat ttatgacatt tctgatcttc 1572241 tgaattattt cccttatcgc tatgatgact acgagctgag ggatttagaa gaagtaaagc 1572301 atgatgaaag agtcacagtc gaagggaagg ttcattcaga gccttctctt acctattacg 1572361 gaaaaaaacg aaacaggctg acattcaggc ttctggtcgg ccactattta atcacagccg 1572421 tatgttttaa ccggccttat ttgaagaaga agctttcgct cggctctgtg gtgacggttt 1572481 caggtaaatg ggacaagcac cgccaaacca tctctgttca ggagttgaaa aacgggccgc 1572541 atcaagaaga caaaagcatt gaaccagtgt attctgtgaa agaaaatgtt accgtcaaaa 1572601 tgatgaggcg ctttattcag caggcgctga cccaatatgc agactcactt cctgatcctc 1572661 ttccggaaaa gctaagaaaa agctataaac tgcctgacta ttatcaagcg ttaaaagcaa 1572721 tgcaccagcc tgaaacaagg gaagcattaa agcttgccag acggcggttt gtttatgaag 1572781 aatttttgtt gtttcagttg aaaatgcagg cgttccgaaa ggcggaaaga gagcagacac 1572841 aagggatacg gcagcgtttt tcaaacgaag aactcatgag atttatcaaa agcctcccgt 1572901 ttcccctcac aaacgcccag tcacgcgttc ttcgcgaaat aacagcagac atgtcttctc 1572961 catacagaat gaaccgtctt cttcaagggg acgttggatc aggaaaaacg gcagtcgccg 1573021 ccattgcact gtatgccgcg atcctatccg gataccaagg agcgctcatg gtgccgacag 1573081 aaattctggc cgagcagcat gctgattcgc tcgtttcgct atttgaaaaa tgggacgtca 1573141 gcgttgctct tttgacaagc tctgttaaag gaaagcggcg aaaagaactg cttgagcgtc 1573201 ttgcggcggg tgagattgat attcttgtag gaacccatgc tttaatccaa gacgaggtgg 1573261 agtttaaggc gttgagtctc gttattactg atgaacagca cagatttgga gttgagcagc 1573321 gcaaaaagct tcggaacaaa gggcaggatc ccgatgttct ctttatgaca gccactccaa 1573381 tcccaagaac attagcgatc acagtattcg gtgaaatgga tgtatctgtc attgatgaga 1573441 tgccggctgg acgaaagcga attgaaacct attgggtaaa acatgacatg cttgatcgta 1573501 ttttggcatt tgtcgaaaaa gaattaaagc aaggcaggca ggcttatatc atctgtccgc 1573561 tgattgaaga atcagataag cttgatgtgc aaaacgccat tgacgtgtac aatatgcttt 1573621 ctgatatttt tcggggaaaa tggaatgtcg gccttatgca tggaaagctg cattccgatg 1573681 aaaaagatca ggtcatgaga gaattcagcg caaatcactg tcaaattctc gtatcaacca 1573741 ctgttgtgga ggttggcgta aatgttccga atgcaacaat tatggtgatt tatgacgccg 1573801 accgtttcgg actatcacag cttcaccagc tgcgcggccg tgttggacgg ggtgagcatc 1573861 aatctttctg tattctgatg gctgatccaa aatcagaaac agggaaagaa cggatgagga 1573921 tcatgtcgga gaccaatgac ggtttcgagc tgtctgaaaa ggatctggaa ctgagaggtc 1573981 ccggtgattt cttcgggaaa aaacaaagcg gaatgccgga atttaaagtg gcggacatgg 1574041 ttcatgatta cagagcgctt gaaacggcaa ggcaggatgc tgcgaatctt gtggcttctg 1574101 acgcgttctg gaaggagccg gaatacgctg tgttaagaga tgaattgctg aagagcggag 1574161 taatggacgg ggaaaaatta agctgagtat cagaagtttt tggtgttcag ccagaaacaa 1574221 tcgttgcatt ccaatctatg aaattatata ctactattag tacctagtct taattgtccg 1574281 gatggtgttt agatatgaga agaaataaga gagaacgcca ggaattactt cagcagacga 1574341 ttcaagcaac cccctttatt acagatgaag aactagcggg taaattcggg gtgagcatcc 1574401 agacgatacg tttggaccgc ttagagcttt ccatacctga actgagagaa agaattaaga 1574461 acgtggcaga gaaaacactt gaggacgaag tgaagtccct gtcacttgat gaagttatcg 1574521 gagaaattat tgaccttgag ctggatgatc aggcgatatc cattttagaa ataaaacagg 1574581 agcacgtgtt cagccggaat cagattgcga gaggacacca tttatttgca caggcgaatt 1574641 ctttggccgt tgcagtcatt gatgacgagc tggcgctgac tgcaagtgca gacatccgct 1574701 ttacaagaca ggtaaagcag ggtgaacgtg tcgtagcaaa agcgaaagtg acggctgtcg 1574761 aaaaagaaaa aggaagaacg gttgtcgaag tgaacagcta cgttggcgaa gaaattgttt 1574821 tttctggacg ctttgacatg tatcgttcaa aacattcata aaggtggagc atgcatgaga 1574881 atagctgtag atgcaatggg aggagaccac gctcccaaag ctgttattga cggagttata 1574941 aaaggtatag aggcatttga tgatctccat atcacacttg tcggtgacaa aacaacgata 1575001 gaatcacatt taacaactac atcagatcgc atcacggtgc tgcacgcaga tgaagtgatt 1575061 gagcctacgg atgaaccggt ccgtgccgtg cgaagaaaaa agaactcatc tatggttctt 1575121 atggcgcagg aggttgcgga aaacagagct gacgcctgca tttcagcggg aaataccggt 1575181 gcattaatga cagccggtct ctttattgtc gggagaatta aaggaattga ccgtccggcg 1575241 cttgctccga cacttccgac tgtttcggga gacggatttc ttctccttga tgtcggcgcc 1575301 aatgtcgatg ccaaaccgga gcacctcgtt caatatgcca tcatgggttc tgtttattct 1575361 cagcaagtgc gcggtgtcac ttcaccgaga gtcggacttt taaatgtcgg aacagaagat 1575421 aaaaaaggaa acgaactgac gaagcagacg tttcaaattt taaaagaaac agcaaacatc 1575481 aattttatcg gaaacgtgga agcgcgagac cttttagatg atgtggcgga tgttgtagta 1575541 acagacggct ttaccgggaa tgttacactc aaaacgctgg aaggctctgc gttgtcaatt 1575601 tttaaaatga tgagagacgt aatgacgtct actttgacat ccaagcttgc agcagctgtg 1575661 ctgaaaccaa aattgaaaga aatgaaaatg aaaatggagt attcgaatta tggcggagca 1575721 agtctttttg gcttaaaagc gcctgtgatc aaggcgcacg gctcttcaga ttcaaatgct 1575781 gtattccatg cgattcggca agcaagagag atggtcagcc aaaatgtggc tgcgctcatt 1575841 caggaagaag tgaaagaaga aaaaacagat gagtagtctg gaggttttta catcatgagt 1575901 aagattgcat ttttattccc gggtcaggga tcacaattta tcggcatggg aaaagagctt 1575961 tatgagcagg tgcctgctgc aaagcgtctg tttgatgaag ccgatgaaac gttggaaaca 1576021 aaactcagct cgcttatttt tgagggggat gctgaagaat taacacttac atacaatgcg 1576081 cagcctgctt tgcttacgac aagcatcgct gttcttgaga aatttaaaga atctggcatt 1576141 acacctgatt tcacagcagg acacagcctt ggtgaatatt ctgcactggt tgcggctggc 1576201 gctctgtctt tcaaagatgc tgtttatact gtcagaaagc gcggagagtt tatgaatgaa 1576261 gcggtgccgg ctggcgaagg agcaatggct gcgattctcg gcatggatgc tgaagcatta 1576321 aagcaagtaa ccgataaagt cacagaggaa ggcaaccttg tacagcttgc gaatctcaac 1576381 tgtcctggcc aaatcgtcat ttccggaaca gctaaagggg ttgagcttgc atctgaactg 1576441 gcaaaagaga acggcgcaaa acgcgcaatt ccgcttgaag taagcggtcc gttccattct 1576501 gaactgatga aaccggctgc tgaaaagctg aaagaggtat tggacgcctg tgacataaaa 1576561 gacgctgacg ttccggtcat ctcaaatgtt tctgctgacg tgatgactga aaaagcagat 1576621 atcaaagaaa aacttattga gcagctttac tctccggttc gttttgagga aagcattaac 1576681 aagctgatcg cagagggtgt tacgactttt attgaaatcg gtcccggaaa agtgctttca 1576741 ggccttgtga aaaaagtgaa tagacggtta aaaacaattg ctgtatcaga tccggaaacg 1576801 atcgagctgg caattcaaac gcttaaggag gagaatgata atgcttaatg ataaaacggc 1576861 tattgtcact ggcgcatccc gcggaatcgg ccgctcaatc gcccttgatc tggcaaaaag 1576921 cggagcaaat gttgtcgtga actactccgg caatgaagcg aaagcaaatg aagtggtaga 1576981 tgaaatcaaa tcaatgggca gaaaagcaat tgctgtaaaa gcggatgtat caaatcccga 1577041 agatgtacaa aacatgataa aagaaacatt gtctgttttt tctacgattg acattctggt 1577101 taataatgcg ggaattacaa gagacaatct catcatgaga atgaaagaag acgaatggga 1577161 tgacgtcatt aacattaacc tgaagggtgt tttcaactgc acaaaagctg ttacaagaca 1577221 aatgatgaaa cagcgttcag gccgcattat taacgtatcg tctatcgtcg gcgtcagcgg 1577281 aaaccctgga caagccaact acgtggctgc aaaagccggc gtcatcggtt taaccaaatc 1577341 ttctgctaaa gagctcgcca gccgaaatat tacggtaaac gcaatagcgc caggatttat 1577401 ctcaactgat atgacagata aacttgcaaa agacgttcaa gacgaaatgc tgaaacaaat 1577461 tccgctcgcg cgctttggtg aacctagcga tgtcagcagt gttgtcacgt tcctagcttc 1577521 agagggagct cgttatatga caggccaaac gcttcatatt gacggcggaa tggtgatgta 1577581 agttttttct cgaaaatttc atcgtagttt ctctagtttt ttaaaaacga atccactata 1577641 atacttgagg ggaggtgaat tgctatggca gacacattag agcgtgtaac gaaaatcatc 1577701 gtagatcgcc ttggcgttga tgaagcagac gtcaaacttg aagcttcttt caaggaagac 1577761 ttaggtgctg attccctaga tgtagttgag cttgttatgg aacttgaaga cgagtttgat 1577821 atggagattt ctgacgaaga tgctgaaaag attgcaacag tcggcgacgc tgtgaactac 1577881 atacaaaacc agcaataagc tgatgctaaa agtcccgccg aaacgcgggg ctttagccct 1577941 ttattcgtgc agttattaca gcatgccgct tttacgcgcg ctgtatccgg tttagtcaga 1578001 gaagcgcggt gaacctgatg tgcctatgga ggttactatg tcaaaacact cacattataa 1578061 agataaaaaa aagttctata aaaaagtaga acaatttaaa gagtttcaag aacggatttc 1578121 ggttcacttt caaaatgaaa agcttttgta tcaagcattt acacattcat cttatgtgaa 1578181 tgagcatcgg aaaaagccgt atgaagataa tgaaaggctt gaatttttag gtgacgctgt 1578241 tttggaactg acgatctcca gattcttatt tgccaaatac ccggctatga gtgaaggaga 1578301 tttgacgaaa ttgagagccg caattgtttg cgaaccgtct ctcgtttcat tggctcacga 1578361 gctgtcattc ggcgatcttg tcctgttggg taaaggcgag gaaatgacag gcggaagaaa 1578421 gcgtcctgct ctattggcgg atgtttttga ggcatttatc ggagccttgt accttgacca 1578481 aggattagag ccggtcgaaa gtttcttaaa agtttatgtg ttccctaaaa ttaacgatgg 1578541 tgctttttct catgtgatgg atttcaaaag ccagctgcag gaatacgtgc agcgggacgg 1578601 caaaggctct ctggagtata aaatctccaa cgaaaaagga cctgcgcaca accgtgaatt 1578661 tgaagccatc gtatctctaa aaggtgaacc actcggagtc ggaaacggcc gttcaaagaa 1578721 agaagccgaa cagcacgctg ctcaggaagc tttagctaaa ttgcaaaaac accatacgaa 1578781 acaataaaat cccccttatg actcaggggg atttcagtat gtatgccgtc ttatttgacc 1578841 aatgtttatg atagaattga aatacttatt acataaggag gatcgctatg ttcctcaaac 1578901 gtttagacgt tataggattt aaatcatttg cagaacggat ttccgtagac ttcgttaaag 1578961 gcgtgacagc agttgtcggg ccgaacggaa gcggaaaaag caacatcacg gatgccattc 1579021 gctgggttct cggcgaacaa tcggcacgct ctcttcgcgg cggaaaaatg gaagacatca 1579081 tttttgctgg gagtgattca agaaagcgat taaatctagc tgaagttacg cttactcttg 1579141 ataatgatga tcatttcttg ccaattgact tccacgaggt gagtgtcaca agacgtgtgt 1579201 acagatcagg tgagagtgag tttctgatta acaatcagcc atgccgcttg aaagatatta 1579261 ttgatttatt tatggactct gggcttggta aagaagcatt ttctattatc agccaaggga 1579321 aagtggaaga gatcctgagc agcaaagcgg aggatcgccg cagtatcttt gaagaagcgg 1579381 ccggggtgct taaatataaa acgagaaaga aaaaagcaga aaataaactg tttgagacac 1579441 aggacaatct aaatcgggta gaagatatat tacatgagct tgaaggacag gttgaacctc 1579501 ttaaaattca agcttcaata gcgaaagact accttgagaa aaagaaagag ctggagcatg 1579561 ttgaaattgc gctgactgcc tatgatatcg aagagctgca tggtaaatgg tcgactctta 1579621 aagagaaagt gcagatggca aaagaagaag agcttgctga atcgtctgct atttctgcga 1579681 aagaagcaaa gattgaggat acaagggaca aaatacaagc gcttgatgag tcagtagatg 1579741 agctccagca agttttactg gtaactagtg aagagctgga aaagcttgaa ggccgtaaag 1579801 aagtcctgaa agaacgaaag aaaaacgctg tgcaaaacca agaacagctt gaagaagcca 1579861 tcgttcagtt ccagcaaaaa gaaacggttc tgaaagaaga gctttcgaag caggaagctg 1579921 tcttcgaaac gcttcaggct gaggtgaagc agttaagggc gcaagtaaaa gaaaaacagc 1579981 aggctctcag tcttcacaat gaaaatgtcg aagagaaaat cgagcagctg aaaagtgatt 1580041 attttgagct gttaaacagc caggcttcga tacgcaacga actccagctt cttgatgacc 1580101 agatgtccca atccgctgtc acattgcaga gacttgcgga caacaatgaa aagcacctgc 1580161 aggaacggca tgatatttct gcgcgtaaag ccgcatgtga aacggaattt gcccgaattg 1580221 agcaggagat tcacagtcaa gtcggtgcat atcgtgatat gcagacaaaa tatgagcaga 1580281 aaaagcgcca atacgaaaaa aatgaatccg ctctgtatca ggcataccaa tacgttcagc 1580341 aagcgagatc aaaaaaggac atgcttgaga cgatgcaggg agatttctcc ggcttttatc 1580401 aaggtgttaa agaagtgctg aaagcgaaag agcgccttgg cggaattcgc ggagcggttc 1580461 ttgagctgat ttctacagaa cagaagtatg aaacggccat tgaaatagcg ctcggcgctt 1580521 ctgctcaaca cgtcgtgacc gacgatgaac aatctgcccg caaagcgatt caatatttaa 1580581 agcagaattc cttcggccgg gcgacgtttc tgcctctttc tgttattaga gaccgccagc 1580641 ttcaaagccg tgacgcggaa acagccgccc ggcattcatc atttctcggg gttgccagtg 1580701 aacttgtcac atttgatcct gcgtatcgaa gcgtcatcca gaatcttctt ggaaccgttc 1580761 tgatcacaga ggacttaaag ggtgcaaacg agcttgcgaa gcttctcggg caccggtacc 1580821 gcatcgtaac ccttgaggga gatgttgtga accccggtgg ttcaatgacg ggcggcgcgg 1580881 ttaaaaagaa aaataactcc ctccttggaa gaagccggga gctagaagat gtgacgaaac 1580941 ggctcgctga aatggaagag aaaacggcac tgcttgaaca agaggtcaaa acccttaagc 1581001 actccattca ggatatggag aaaaaactgg ctgacttaag agaaaccggg gaaggcttaa 1581061 ggttaaagca gcaggatgtg aaaggccagc tgtacgaact tcaagttgcc gagaaaaata 1581121 tcaataccca tttagagctc tatgatcaag aaaaatctgc tctgtcagaa agcgatgaag 1581181 agagaaaagt gcgcaaacgc aagcttgaag aagagctctc tgccgtatct gaaaagatga 1581241 aacagcttga agaggacata gacagactga caaaacaaaa acaaacgcaa tcctcaacga 1581301 aagagtctct ctccaacgag ctgactgagc tgaagatcgc agcggccaaa aaagagcagg 1581361 cttgcaaggg ggaagaggac aaccttgcca gattaaagaa agagctcact gaaacagagc 1581421 ttgcgttaaa agaagcaaaa gaagacttaa gcttcttaac gtcagagatg tcatctagca 1581481 ccagcggcga agaaaagctg gaagaagcag caaaacataa attgaatgac aaaacgaaaa 1581541 cgatcgaact gattgcatta aggcgcgatc agcgcatcaa gcttcagcat gggcttgata 1581601 cgtatgagcg tgagctgaaa gaaatgaaac gcctgtataa acaaaaaaca acgctcttaa 1581661 aagacgaaga agtcaaactt ggacgaatgg aagtcgagct tgataattta ctccaatact 1581721 tacgggagga atacagcttg tcctttgagg gggcaaaaga gaaatatcag cttgaaactg 1581781 atccagagga agccagaaag cgcgtgaagc tgattaaact cgcaattgaa gagctgggta 1581841 ccgtgaacct cggaagcata gatgagtttg agagggtcaa cgaacggtac aagtttctgt 1581901 cggaacaaaa agaagattta acagaagcga aaaatacctt gttccaagtg attgaagaaa 1581961 tggatgaaga aatgacgaag cgctttaacg acacattcgt ccaaatccgc tcacactttg 1582021 atcaagtttt ccgctcctta ttcggaggag ggcgagctga actgaggctc accgatccta 1582081 acgatctgct tcattcagga gtcgagatta tcgctcagcc gccggggaaa aagctgcaaa 1582141 acttaaacct cctgtcaggc ggagagcgtg cgcttactgc tatagcgctc ttattctcaa 1582201 tcctaaaggt tcgtccagtg ccgttttgcg tccttgacga agtagaggct gcgctcgacg 1582261 aagcgaatgt gttccgattt gcgcagtatt taaaaaaata cagcagcgat actcagttta 1582321 ttgtgattac ccacagaaaa ggaacgatgg aggaagcgga tgtgctttat ggcgtaacca 1582381 tgcaggaatc cggtgtttcc aaggtaattt cagttaagct ggaagaaaca aaagaattcg 1582441 ttcagtaacg aggaaagagg ttaaaagatg agctttttta aaaaattaaa agagaaaatc 1582501 acaaaacaga cagattccgt atctgaaaag tttaaggatg gccttgaaaa aacaagaaac 1582561 tcctttcaaa acaaagtgaa tgatcttgta tcccgttacc gtaaagtgga tgaggatttc 1582621 ttcgaagagc ttgaagaggt tcttatcagc gcggatgtcg gttttacaac cgttatggaa 1582681 ttaatagatg agctgaaaaa agaagtcaaa cgcagaaata ttcaagatcc aaaggaagtc 1582741 cagtcagtga tttctgagaa actggtcgag atttataaca gcggagatga gcaaatttca 1582801 gaactgaaca tccaggatgg gcgtttaaac gtaatccttc tggtaggtgt aaacggcgtc 1582861 gggaaaacaa caacgatcgg aaagcttgct cataaaatga aacaagaagg aaaatctgtt 1582921 gtacttgccg ccggagacac ttttagagcg ggagccattg aacagctgga agtatgggga 1582981 gagcgtacag gagtgcctgt cattaagcag acggcaggaa gcgatccggc ggctgtcatc 1583041 tacgatgctg ttcatgctgc gaaagcaaga aatgccgatg tattaatttg tgatacggca 1583101 gggcgtctcc aaaacaaagt aaatctcatg aaagagcttg aaaaagtaaa acgtgttatc 1583161 gaaagagaag ttcctgaagc tccgcatgag gtgctgcttg cccttgatgc cacgaccggc 1583221 caaaatgcaa tggctcaggc aaaagaattc tctaaagcaa caaatgttac cggcattgct 1583281 ttaacgaagc ttgacggtac ggcaaaaggc ggtatcgtcc ttgcgattcg caacgagctt 1583341 cacatcccgg ttaaactagt cggtttagga gaaaaagttg atgaccttca ggaatttgat 1583401 ccagaatcct atgtgtacgg actcttttca gatttagtgg aaaaagccga cgattaagaa 1583461 aaaggcccca acatcttggg gcctttttct tttttatctt cttacttgat aggcgaaatg 1583521 ataaaggctg ttatcagtgg ataccagtct tgactcacca gaaaaaactc tgaatgggat 1583581 gatgtcatag taatgaacgg aaacagatgt gtaatacgta tagtaaccag cagctggccc 1583641 caaatacatt ggaacctcaa atgttccgtt tgcatcagtc gttcctgaag cagtttgtgt 1583701 tgtgtttccg accttcgtgt ccgcttcaaa tcttacgggc gcgtttggca ctggctgtcc 1583761 gttttggtcg agtaatttgc cgcttactgt aatattgtac ttgactcgcc aatattgacc 1583821 ttgtccgtaa ttgattttac cgtatacccc tccatctgtg ctgatatttg tgattgaggc 1583881 cttataaggt gcctcagcag cgtctgcttg ctgtgccggg aaacctattg taaacagggc 1583941 tgccagacat aacataaaca ataaaccgat ttttttcata aaaatcctcc ttaaaatagg 1584001 gttcatatac aatatcggaa taaattggat gatatttagc gtattttgga aaagttaatc 1584061 gccgctttga caagataaaa acttgacagt gtcattaaaa ccgtgtaaac taagttatcg 1584121 taaagggatt tgacttaaca aaggggagag ctcaaatgtc actcgaaaag acaacgagaa 1584181 tgaattatct gtttgatttt tatcagtcgt tgttgacgtc aaaacagaag agctatatgt 1584241 cgctttatta tttggacgat ttctccctag gcgaaatagc cgaagaatat gaggtttcaa 1584301 gacaagctgt ttatgataac atcaaacgaa cagaagcaat gcttgaacaa tatgaagaaa 1584361 agctgctcct tttgaaaaag tttcaggagc gtaaagagat gtttaataag ctgaaggagc 1584421 ttgcttccgg ttcaaaagaa gaggaagaaa ttacagctct gattgaagcg cttgagaaat 1584481 tagattagga ggcggcaaac tatggcattt gaaggattag ccgaccgact gcagcagacg 1584541 atttctaaaa tccgcggaaa agggaaagtc agcgaacaag atgtaaaaga gatgatgcgt 1584601 gaggtccgtc ttgcgctgct tgaggctgac gttaacttta aagtagtcaa ggattttgtc 1584661 aaaaaagtaa gtgaacgcgc tgtaggccaa gacgtcatga aaagtctgac gcccggccag 1584721 caggtcatta aagttgttca agaggaactg actgagctga tgggcggcga agagagcaaa 1584781 atcgccgtcg caaaaaggcc gccgactgtt attatgatgg tcggtctcca aggtgccggt 1584841 aaaacgacaa caagcggtaa gcttgcgaat ctgctgcgca aaaagcataa tcgcaaaccg 1584901 atgctggttg ctgccgatat ttaccgccca gccgcaatta agcagctgga aacactcggc 1584961 aaacagcttg atatgcctgt tttctctctt ggcgatcagg tcagtcctgt agaaatagct 1585021 aaacaggcta ttgagaaagc caaggaagaa cattatgact acgtcatttt ggatacggca 1585081 gggcgcttgc atatcgacca tgaactgatg gatgaactga ccaacgtcaa agaaatcgcg 1585141 aatccggaag aaattttcct ggttgtcgat tcaatgaccg gtcaggacgc tgtgaatgtt 1585201 gccaaaagct ttaatgaaca gctcggttta accggtgttg tgttgactaa gctggatgga 1585261 gacacacgcg gcggggctgc gctttctatt cgcgctgtca caaacacgcc aattaagttt 1585321 gcaggtttgg gcgaaaagct tgatgcgtta gagccgttcc atcctgaacg catggcatca 1585381 aggattctcg gcatgggcga cgtgctgaca ttgattgaaa aagcacaggc cagcgttgat 1585441 gaagacaaag ccaaagagct ggaacaaaaa atgagaacga tgagcttcac attggacgat 1585501 tttctggagc agctcgggca agtcagaaac atggggccgc ttgatgagct tctgcaaatg 1585561 atgccgggtg caggtaaaat gaagggcctg aaaaacatcc aagttgatga aaaacagctg 1585621 aatcatgtgg aagcaatcat caaatcaatg actgttcttg aaaaagaaca gccggatatt 1585681 atcaatgcca gccggcggaa gcggattgca aaaggaagcg ggacatccgt acaggaagtc 1585741 aaccgtctgc ttaagcagtt tgatgaaatg aaaaaaatga tgaagcagat gacaaacatg 1585801 tcaaaaggca agaaaaaagg gtttaagcta ccttttatgt aatcggttat acatgataaa 1585861 accgttgtta agaaaaaaca ctttacaaac acttttatca ttgttaatat actatcttgt 1585921 tgaaatattt tcggaggtgc tagtaaaatg gcagtaaaaa ttcgtttaaa acgtatggga 1585981 gcaaaaaaat ctcctttcta tcgtattgtt gtagcagatt ctcgttcacc acgtgacggc 1586041 cgtttcatcg aaacagtcgg aacttacaac ccggttgcaa aaccagcgga agtaaaaatt 1586101 gacgaagagc ttgctcttaa atggcttcaa actggagcga aaccatctga tacagttcgc 1586161 aacttgttct ctagccaagg aatcatggaa aaattccaca acgctaaaca aggcaagtaa 1586221 tgactgatca acacttggaa gatttgattg tccacattgt gacgccgctt gttgatcatc 1586281 cagatgacat tcgcgtcata agagaagaaa ccgatcaaaa gattgcgctg cgcttatctg 1586341 tccataagtc agataccggt aaagttatcg gaaagcaagg ccggactgca aaagcgattc 1586401 gaacagctgt atttgcagct ggcgtacagt cttctaagaa agttcaattt gaaatatttg 1586461 actaaaaggg agagggccgg cacctcccct ttttttacac gcaaaaaaag ggtaaactga 1586521 tagaagctta ggcaaaatag aaaagcctgg acgagtaaaa gttttaaaag cggggagctt 1586581 ggtgcgatgc aaattattca ccgtgtagcc gttatgcaag tcttaaccga gcgcagtaaa 1586641 gaaaagcttt tagcttcttt tgctgagaag aaacaaatgc ttgaacgaga atgcagccag 1586701 ctctattttc agcttagaaa acatgagaaa gaacagcaaa accctaatat gattgaacaa 1586761 tttaaaaagg caatagaaaa gcgaaaagat gatataaaaa tcattgattt tcaaattgct 1586821 caagtacata cattgccgct tggcagtgag ttgaaagaaa aggaagtcga tgcgctgctg 1586881 acgattgaag ccggggatga ctggcatgag aaaacagcag cgaacaccat cgtcataaaa 1586941 gacggaaaag taattgaaat tcgccagagg tgatcatatg acaaagcgat ggtttaatgt 1587001 aggcaaaatc gtaaataccc acggaatcaa aggcgaagtg cgggtgattt caaaaacaga 1587061 ttttgccgaa gaacgataca agccgggaaa cacgctgtat ttgtttatgg acggccgtaa 1587121 cgaaccagtg gaggtaacgg taaacacaca tagactgcat aagcaatttc atctcctgca 1587181 gtttaaagaa agacaaaacc taaatgaagt agaagagctg aaaaacgcaa tcattaaagt 1587241 tcctgaagaa gaattaggag agctgaatga gggtgaattt tatttccacg aaattattgg 1587301 gtgtgaagta tttactgaag aaggcgaact catcggaaag gtcaaagaaa ttttgacgcc 1587361 tggagccaat gacgtttggg tcatcggacg aaaaggaaaa aaagacgcac tcattcctta 1587421 cattgaatca gtggttaaac atatcgatgt cagggaaaag aaaattgaga ttgaactcat 1587481 ggaagggtta atagacgaat gaaaatcgat tttttgacgc tgtttcccga aatgtttgaa 1587541 ggcgtgctcg gctcatcgat tcttcaaaaa gcccaggaaa aagatgcggt gcagtttcaa 1587601 gtcgtaaatt tccgagagta ctctgataac aagcacaata ctgttgatga ttatccttat 1587661 ggcggcgggg caggcatggt tctcaagccc cagcctgttt ttgacgcggt cgaggacctg 1587721 acatcaaagg cagccgctgc tccgcgtatt atcctcgtat gcccgcaagg tgagcgtttt 1587781 acccaaaaaa aagccgaaca attagctaag gaagagcatt tgctgttcat ttgcggccac 1587841 tatgaaggct atgatgaacg cattcgcgag cacttggtaa cggatgaaat atcaattggc 1587901 gactttgttc tgacgggcgg tgagctccct gcaatgatga tcgcagacag tgtggtcaga 1587961 ctgcttccgg gtgtactggg taaagaggct tcccatattg aggattcctt cagcaccgga 1588021 cttttagagc acccgcatta tacaagaccg gcagattaca aaggtttaaa agtgcctgaa 1588081 acactcttgt caggaaacca tgcaaaaatt gaagaatggc ggaataaaga atcgatcaga 1588141 aggacctacc taagacgtcc ggatctgttg aaagaccacc cgcttacaga gcagcaaaga 1588201 aagtggattt ctgaatggga aaaagaatag attttattgc ataggctatg aaattgtgat 1588261 aagatactac ttgtggctta agcgggctta tccgctgcaa gcttgaaaac gatgttccgc 1588321 tgtgccggtt tttgtggcca agagcatctg ttggaaggag ttgaaaacga tgcaaaaact 1588381 aattgaagat atcacaaaag aacagcttcg tactgatctt cctgcgttcc gtcctggtga 1588441 cactttacgt gtacacgtta aagttgttga gggtaaccgt gagcgtatcc agatctttga 1588501 aggtgttgtg attaagcgtc gtggtggtgg aatcagcgaa acgttcacag ttcgtaagat 1588561 ttcttacggt gttggcgttg aacgtacttt cccagtacac acaccaaaaa tcgcgaaaat 1588621 cgaagttgta cgttacggta aagtacgccg tgctaaactt tactacctgc gtgaacttcg 1588681 cggaaaagcg gctcgtatta aagagatcag acgataatga taacgaacga aaagagcttg 1588741 ttacctgtaa caagctcttt ttttatacag aatttgaaaa tgccggacag gcatcgtaaa 1588801 atacataaag gacaacaatg aatcatgcat actgaagata aaggcggtgt tcgtgtcaca 1588861 tgacaattca atggttcccg ggccatatgg caaaagcaag aagggaagta accgaaaaat 1588921 taaaattaat cgatatcgta tatgaattgg tagatgccag aattccaatg tcatcaagaa 1588981 acccaatgat tgaagatatt ctaaaaaaca agccgcgaat tatgctgtta aacaaggctg 1589041 acaaagcaga tgcggcagtt acacagcagt ggaaagagca ctttgagaac caggggatcc 1589101 gctctctgtc tattaattct gtaaatggac aagggttaaa tcaaattgtg cctgcatcaa 1589161 aagagatcct ccaagaaaaa tttgaccgga tgcgtgcgaa aggtgtgaag ccgagagcga 1589221 ttcgcgcttt gattatcggc attccaaacg tcggaaaatc aacgctcatc aaccggcttg 1589281 caaagaaaaa catagcaaaa acgggagaca gacctggtat tacgacttct caacagtggg 1589341 tcaaagttgg gaaagaatta gagctattag atacaccggg aattttgtgg cctaaatttg 1589401 aggatgagct tgtcggtttg agactggcag tcaccggggc tattaaagac tcgattatca 1589461 atttgcagga cgtggccgtg tttggtcttc gttttctcga agaacattac ccagaacggc 1589521 ttaaagagcg ttatggcctt gatgagatcc cagaggacat tgccgagctg tttgatgcaa 1589581 taggtgaaaa gcggggctgt ctcatgagcg gtgggctcat caactacgat aagacgactg 1589641 aagtcatcat tcgcgatatt cgcactgaaa agttcggcag gctgtcattt gaacagccga 1589701 cgatgtaaag gcgcgcagaa atgcgggtct ttattttttc ttggctgaac cgatacatac 1589761 agtaagggag aagagaaagt gaatacatta accgtaaagg acattaaaga ccgtttgcag 1589821 gaagtgaagg atgcacaaga cccatttatt gcccaatgcg aaaacgaccc gagaaaaagc 1589881 gttcaaacgc ttgtagagca atggcttaaa aagcaagcga aagaaaaagc gctgaaagaa 1589941 caatgggtga atatgacttc ctatgaaagg ctggcaagaa acaaaggatt tcgcttgatt 1590001 gcaggtgttg acgaggtcgg ccgggggcca ttggcaggac cagttgtcgc cagcgcagtc 1590061 atccttccag aggaatgtga aatacttggg ctgacagact ccaaaaagct ttcagagaaa 1590121 aaacgcgagg aatattacga gcttattatg aaggaagcac tggcggtcgg gataggaatt 1590181 gtagaagcta ctgtgattga tgagatcaat atatatgaag cttcaaaaat ggcaatggtg 1590241 aaagcgatac aggatttgtc ggatacacct gattatttgc ttgttgacgc aatgacactt 1590301 ccgctcgaca cggctcaggc gtcaattata aaaggcgatg ccaaaagcgt gtctattgcg 1590361 gcaggtgcgt gtatcgcaaa agtgacgagg gaccgaatga tgagcgctta tgccgaaacg 1590421 tatcccatgt acggctttga aaaaaataaa ggctatggga caaaagaaca tttggaagct 1590481 ctcgctgcat acggcccaac tgaattgcac cgcaaaactt tcgctcctgt tcaatctttc 1590541 agataaatca ccatggacaa ggaggcacct ttttaaaatg aacatacgaa atgatgtgca 1590601 aaaggcgctg cagcaccttt tcgggcgtac agccgtcccg caggaaacat caaaagtaaa 1590661 cgaagcgcta aacggggaga agcgtctcct cttaggaaaa gtgcttcgtt tactaggaga 1590721 tcagcatgcc ctgatccaag tcggcaatca aactgttcag ggaaaacttg aaactcagct 1590781 tcgtcctcag gcatactatt ggttttccta cgaaaaaaaa acggcagagc aaacaggccg 1590841 tcttcaggtc gttcaaagct ttgatcaaaa tcctaaaacc attcaggatg cagctggcaa 1590901 acttttaaat gctatttcag tgaagacgtc aaacgcagct ctcatgatga caggagcgat 1590961 gctgaaaagc aaaacacccg taacagaaaa tgatatcaaa acagctgtcc gctggatgga 1591021 cacgctgcct tcgcaagaca caaaaaaagc agttgaaacg gttctcttcg ctttaaagcg 1591081 tgatcttccc attcactccg agattttgaa tggtgttcac gctgtgaaat cgcctgttcc 1591141 gttgcatcag cacgtatccc agctgctaca ggcaatcgac caaaaccctc agcagagcca 1591201 aatgatgtca aagctaaagg aagcagtcac ggtgctttta aatagtgaaa tcgatgtcca 1591261 tgcagaacgg ctgattgata agcttatttc tttaaccgac aatacgaaag caccttctcc 1591321 gacgaataca gctggaagca gggagcttag cacaccagct ggctcccccg gaaaagccag 1591381 cctgccgatt gcaaatcaca cagcagaaca gggaagcata caagaagagc ctgttaaaac 1591441 agcagcagac attccaatta aagaagcccg ccagctgctg gtgaagctga cggaatctgc 1591501 tgaaaaaaac agtctccaaa ttgtgaaaga agcagcaaat tggattaaag cggctgcttc 1591561 atcgggtgat agtaagtcac ttgcagcttc agctgtttta caggcggcac aagtcacaga 1591621 tcaggaagcc gaagtctttt taaaggctgt tcagcagaca gcaccccatt tggcggataa 1591681 ggcagatgtt ctttctttct tatccaaagt gaaaacggca atcggcgcaa gggacgaggt 1591741 tgcgttcatt aaagcgtttg aacaaggaag cgcagtcaca tctggcgaaa tgcaatccat 1591801 caagctggct ctttctgcct taagagcatc gcatgaggta gccgaaccag tcaaacaaga 1591861 agccgatcag ctttttcata aattaaatgg ccagcttttc atgcagcagg accatccatc 1591921 atacagccaa attgtaatgt catttccgat gttttcgaag tcaggggttc aggacatgac 1591981 tgttctgttt aaaggaaaga aagaagcgga tggaaagctt gatccttccc attgccgcct 1592041 tttgtttttg ctgcagcttg atacactaaa agaaaccgtc gttgattgct tggtacagca 1592101 aaaagtcatg accattacaa tagagactga tttcgagctg caggctgcga tcgatccgat 1592161 ggtgcccgcg cttaaacagg ggctaaagga aatggggtac agcctttcag gggtaaacgc 1592221 taaaaaaagg gttcacaccg aagaaaaggc ttcaatcgat caatatataa caagtatcag 1592281 tgatcaggaa gtggatgtga aaatatgaaa gagcagacac cgatcagaaa agctgttgct 1592341 ctccattatg acgaacaaaa agacaaggcg ccgagagtga ttgccacagg gaagggccat 1592401 gtagctgaca acattataaa agaagcgaaa aaagcagggg tcccgattca agaagatcgg 1592461 acccttgtcg aattaatgcg ccatttgacg gtagatgatc aaattcctga agctctttat 1592521 gaaacggtag ccgagatttt ttcattcatt tacaaattgg acgaaagcgt aaaaaacaaa 1592581 aaatagctaa aatattcccc atccttcttt gaaatttatg tttttaataa agtaaaagtt 1592641 tgaatgttta gaaggattaa aagattttgc atcgaactgt agacaattct tccagtatta 1592701 ttatagaatg aaagcgcagt ctattttagt tttgttacat aagttaggag gatgggaaat 1592761 gaatatccat gagtaccagg gaaaagaagt cctcagaaaa tatggggtat ctgttcctga 1592821 aggtaaagtg gcttttacag cagaagaagc agttgagagt gcaaagagct tatccagctc 1592881 ggtttatgtc gtaaaggctc aaattcatgc tggcggtcga ggcaaagctg gtggggtaaa 1592941 aatagcaaaa tcattagacg aagtaaaagc gtatgccgaa gaactattag ggaagaccct 1593001 agttacacat cagacgggtc cggacggcca agtaataaaa cgcttactta ttgaagaagg 1593061 ctgcgatatt aaaaaagaat attacatcgg tctagtgctt gaccgcgcca cttcaagaat 1593121 cgttttaatg gcttctgaag aaggcggaac ggaaattgaa gaggttgcgg agaaaacacc 1593181 agaaaaaatc aaaaaagctg tcattgatcc agctgttggc cttcaaggct atcaagccag 1593241 agaaattgca ttcgctatta atattccaaa agagctcgtg ggaaaagctg ctaaatttat 1593301 gcttggacta tataaagcgt ttgttgagaa agactgctca atcgccgaaa tcaatccgct 1593361 tgttgtgact ggcgacggaa atgtgatggc gcttgatgca aaattgaatt ttgacagcaa 1593421 tgcgttgtac cgacaaaagg acattatgga atacagagat ttggatgaag aagatccgaa 1593481 agaaattgaa gcgtccaaat atgatctaag ctacatttcc cttgatggaa atatcggctg 1593541 tatggtaaac ggcgcgggac ttgcaatgtc tacgatggat attatcaagc attatggagg 1593601 agaaccggcc aacttccttg atgtgggcgg cggtgcaacc gcggaaaaag tcacggaagc 1593661 atttaaaatc attctttctg atcaaaacgt taaagggatt tttgtcaaca ttttcggcgg 1593721 cattatgaaa tgtgatgtca tcgcagaagg ggttgttgaa gcgactagac aagttggttt 1593781 gacattgccg cttgtcgtcc gtcttgaagg cacaaacgtg gatctaggga agaaaatcct 1593841 tagtgaatca ggattaaaca ttacatctgc ggaatcaatg gctgacggcg cgcagaaaat 1593901 cgtatcctta gtttaagaaa gaatgaaagg caggggacca aataatgagt gttttcatta 1593961 ataaagatac aagagttatt gtgcaaggga ttacaggttc taccgcttta tttcatacga 1594021 agcagatgct tgaatacggc acaaatatcg ttggcggtgt aacacctgga aaaggcggaa 1594081 cagaagcgga aggtgttcct gtatttaata cagtggctga agcagttcaa acaaccggcg 1594141 ctaacgcgtc tgttatatat gtgcccgcac cgtttgcagc tgatgcgatt atggaagcgg 1594201 tagatgcgga gcttgatctc gtgatttgta tcacagaaca tatcccggtt ttggatatgg 1594261 tgaaggtcaa acgcttcatg gaaggcaaga aaacgagact gatagggccg aactgtcctg 1594321 gtgtcattac gcctgaagaa tgtaaaatcg gcattatgcc cggatacatc cataaaaagg 1594381 gtcatgtagg cgttgtatca cgttcaggaa cattaacata cgaagcggtg caccagctct 1594441 cagaagcggg tgtagggcaa tctacagctg ttggaatcgg cggcgaccct gtaaatggaa 1594501 caaactttat tgacgtttta aaagcgttta acgaagatcc tgacacacac gcagtcatca 1594561 tgattggcga aatcggcggt acggccgaag aggaagcggc agagtgggta aaagccaaca 1594621 tgacaaaacc ggtagtcggt tttattggcg gtaaaacagc acctcctggg aagcgcatgg 1594681 ggcatgcagg cgccattatt tccggcggga aagggacagc tgatgaaaaa atcaaaaccc 1594741 ttaatgcatg cggaatcgaa gttgcagaga caccttctgt catgggtgaa accttaatca 1594801 aggtgctgaa agagaagaac ttgttcgaaa cttgtaaaac gcattaataa aaaagggaca 1594861 gccgtcaagg ctgttcctgc tttttctaac aaaaggaggt caatctattg gatcaggccg 1594921 ctgtctgcct aacgatttgc agaatcaatc aattattatc cccatccctt ctattaaaat 1594981 ggtggaaagc cgatccgtct atgtcgctga catcacccgt gttacaaacg gttactcgtg 1595041 atcaaataaa agcagctgca ttaaaaaacg aaatagaaca attttatcca aagctcccgc 1595101 gtgtacttgc tgcttatcgt gagcaaggca ttaacaccat ccctatttct tcaaagcaat 1595161 atcctttctg gcttaaaagc atttatgatc cccctgccgt actgtttgca aaaggtgata 1595221 tgactcttct ttcgaaaggg agaaaaattg gaattgtagg cacaagaaat ccaacagctt 1595281 atgggaaaca agttgtcaat catcttacaa aagagatctg tcgtaaaggt tgggtgattg 1595341 tcagcggact ggcgtctggg atagacggaa tgtcccatgc tgcaagtatt aaggcgaagg 1595401 ggcggacaat tggcgtcatt gcaggcggat ttcaacacat ttatccccga gaaaaccttc 1595461 agttagcaga tcacatggct aaacaccata tcctgctgtc agagcaccca cctgaaacta 1595521 aaccccaaaa atggcatttc cctatgagaa accgtattat cagcggacta agtgaaggcg 1595581 ttattgtcgt tcagggcaaa gaaaaaagcg gttcgctgat tactgcctat caagcattgg 1595641 aacaagggag agaggtattt gccgtacccg gttcattgtt tgacccttac gccggaggtc 1595701 ctataaaact gatccagcag ggggctaaag ccatatggtc agcagaggat attttcgagg 1595761 aacttcctga gagaaacgtt caatatacgg aacccttttg aattatcgtt tgacaaacgg 1595821 tattgtaata tttaataata gtgaggattt aaagttgcat attgttttct atttaattaa 1595881 tgacgttcat gataaagaat gaaatgttga aagccaaata aagacagctg caaaaataaa 1595941 attgaaatat cttgaaaaga gagagaacac ctcttgaggg ggatgaaaat gtctgattat 1596001 ctagtcatcg tggaatcgcc cgctaaggcg aaaacgattg aacgttactt aggtaaaaaa 1596061 tataaagtaa aagcatcaat gggacatgtc cgggatcttc caaaaagtca aatgggagtt 1596121 gacatagaac agaattttga accgaaatat attaccattc gaggtaaagg cccggtatta 1596181 aaagagctga aaacggctgc gaaaaaagcc aaaaaagtgt atctcgcagc tgaccccgac 1596241 agagaagggg aagcgattgc atggcatttg gcacacagtc ttgatttaga tctcaactca 1596301 gactgccgtg tggtgtttaa cgaaattaca aaagacgcta ttaaggaatc gtttaagcat 1596361 ccccgcatga tcaatatgga tttagtggat gcacagcaag cgagacgtat tttagacagg 1596421 cttgtcggat ataaaatcag tccaatctta tggaaaaaag tcaaaaaagg gcttagcgca 1596481 ggacgcgtgc aatccgttgc cctccgtttg attattgacc gtgaaaaaga gattaacgac 1596541 tttaagcctg aggaatattg gacaattgac ggtacgttct taaaaggtca agaaaccttt 1596601 gaagcgagct ttttcgggaa aaacggcaaa aaacttcctt taaatagtga agctgatgta 1596661 aaagagattc tttctcagct caaagggaat caatatacag ttgaaaaagt aaccaaaaag 1596721 gaacgcaaac gtaatcctgc tttgcctttt accacttcta ccctgcagca ggaagcggct 1596781 cgcaagctca atttcagagc gaagaaaacg atgatgattg cacagcaatt atatgaagga 1596841 attgatttag gaagagaagg aacggttggt ctgatcacgt atatgagaac ggattcaacc 1596901 cgtatttcaa atacggctgt tgatgaagca gctgcattta ttgatcagac atatggaaaa 1596961 gagttcctag gcggaaaacg gaagcctgcg aaaaagaatg aaaatgccca ggatgcccac 1597021 gaagcaattc ggccgacatc agttcttaga aaaccaagtg aattaaaagc agtcctcggc 1597081 agagaccaaa tgagactgta taaattaatt tgggagcgtt ttgttgccag ccaaatggca 1597141 ccggctgttc tcgatacaat gagtgtcgac ctgacaaaca acggtttgac atttcgtgca 1597201 aatggaagta aagtcaagtt ttccgggttt atgaaggtgt atgttgaagg aaaagacgat 1597261 caaatggaag aaaaagaccg gatgctgcct gacttacaag aaggcgacac ggtattatca 1597321 aaagatatag aacctgagca gcattttacc cagccgcctc cgcgatatac tgaggcccgg 1597381 cttgttaaaa cccttgaaga acgcggtatc ggccgtccat ccacatatgc tccgacactt 1597441 gatactattc agcggcgcgg ctacgtggca ttggataata aacgtttcgt tccgactgaa 1597501 ttaggtcaga tcgttcttga cttgatcatg gagtttttcc ctgagatcat taacgttgag 1597561 tttacagcta aaatggagag agatcttgat catgttgaag aaggaaatac cgaatgggtc 1597621 aagattatcg ataatttcta caccgatttt gaaaaacgcg tcaaaaaagc cgaatcggaa 1597681 atgaaggaag ttgagattga accagagtat gctggagagg attgtgaatt gtgcagttct 1597741 ccaatggtat ataaaatggg acggtacggt aaattcttag cttgctccaa cttccctgac 1597801 tgccggaaca cgaaaccgat tgtgaaacaa atcggtgtga agtgcccgag ctgcggagaa 1597861 ggaaacattg ttgagcgaaa atcgaaaaag aaacgggtgt tttacggctg tgaccgttat 1597921 ccggactgtg aattcgtatc atgggacaaa ccaattgaac gaaaatgccc gaaatgcgga 1597981 aaaatgctcg tcgagaaaaa actcaaaaaa ggtatacaag tccaatgcgt ggaatgcgat 1598041 tataaggaag aaccacagaa gtagcggtga gcagggtctt gctcaccttc tttgtgtgtt 1598101 aaaagaaggc cttgaataat aaactaggag atgtgaaaga tgaaccaaca aacagtgaat 1598161 gtaatcggag ccggactcgc aggaagtgaa gcagcatggc agcttgccaa acgtgggatt 1598221 caagtcaaat tgtatgaaat gcggccagtt aaacaaacgc ctgcgcatca tacagataaa 1598281 tttgctgagc ttgtctgcag caactctctt cgctctaata cacttgctaa cgctgtcggt 1598341 gtattaaagg aagaaatgcg tgcgcttgat tcagccatta tcgctgcggc tgacgaatgt 1598401 tcggtgcctg ccgggggcgc tcttgcagta gaccgtcatg aatttgccgc aagtgtgaca 1598461 aatcgggtga aaaatcatcc aaacgtaacc gttattaatg aagaagtgac tgaaattcct 1598521 gaaggcccta ctatcatcgc aacgggtccg ttaacatctg aatcgctgtc tgcccagctg 1598581 aaggagctga ctggagagga ctatttatat ttttatgacg cagcggcgcc aattgtagaa 1598641 aaagacagcc ttgatatgga taaagtgtac ctgaaatccc gttatgataa aggtgaagca 1598701 gcatatttga actgcccgat gacagaagaa gagtttgacc gttttcatga agcattaaca 1598761 tcagcagaaa cagtgccgtt aaaagaattt gaaaaagaga ttttctttga aggctgcatg 1598821 ccgattgaag tcatggcaaa acggggtaag aaaacaatgc ttttcggtcc gatgaaacca 1598881 gttggtctag agcatcctgt tacaggaaaa cgcccttatg ccgtcgttca gctcagacag 1598941 gatgatgctg cgggaacact ttataatatt gtaggattcc agacacattt aaaatgggga 1599001 gaccaaaagg aagttctcaa gttgattcca ggacttgaaa atgtagaaat cgtcagatat 1599061 ggcgtgatgc atagaaacac atttattaac tctccaagcc tgttaaagcc gacttatcaa 1599121 tttaaaaacc gcagtgatct gttctttgca ggccaaatga cgggagtaga aggatatgtg 1599181 gaatcagctg cctcaggact tgtagcaggc attaatgcgg cgaagcttgt attgggagaa 1599241 gagcttgtga tcttccctca ggaaacagca attggcagta tggcacatta tattacaaca 1599301 acaaaccaga agaacttcca gccgatgaat gcaaactttg ggcttttgaa agaattgcca 1599361 gttaaaatta aaaataaaaa agaacgaaat gaacaatacg cgaaccgtgc gattgaaaca 1599421 attcaaacaa tttcgaaaac aatataggta ttgattgcaa cctgagcgcg atttgtgata 1599481 ccatttaaaa gcccttcctg gggaggtatt aggcatggag aatgttaaga atttcgtaaa 1599541 gttattcgtt gaatatttac aaattgaaaa aaattattca caatatacta ttgtgaatta 1599601 tgtggattca attgaagaat tcgagacttt cctgcgcgtt caaggtataa atggatttga 1599661 agaagctgca tatcaagata ctaggatttt tttgacagaa gcctatgaaa aaggtttatc 1599721 gagaagaaca ataagcaaaa agatatctgc attaagaagc ttttataagt ttctgatgcg 1599781 ggaaaagctt attgaagaaa atccgtttca gcttgttcat ctgccaaaac aggagaaacg 1599841 gataccgaag tttctatatc aaaaagagct tgaggagctg tttgaagttt cagatataag 1599901 ccagccggcc ggaatgaggg atcaagcgct gttagagctg ctctatgcca ctggaatgag 1599961 ggtcagtgaa tgctgttcca taactattaa cgacgttgat ttatttatgg acactgtgct 1600021 tgttcacggt aaaggcaaga agcagcgcta tatccccttt gggtcttatg cccgcgaagc 1600081 gttgaaggta tacatgaata gcggaagaca gtgcttgctg atgaaggcaa aagaacctca 1600141 tgatctatta ttcgtaaatc aaagaggcgg accgcttaca gcccgtggca tcagacatat 1600201 tttaagcggg cttgttcaaa aagcgtcaag cactttacat atccatccgc atatgcttcg 1600261 acatacgttc gccacgcatc tgttaaatga aggagcggat ttgagaagcg ttcaagaact 1600321 gctcgggcat tccaatctgt cttctacaca gatatacacg cacgtttcga aggaaatgtt 1600381 gagaaacaca tatatgtctc accatccaag agcatttaag aaaaattaaa ggaggccctt 1600441 tatgtcatct tttcatgcga ccacaatatt tgccgtacag cataaaggac gaagcgctat 1600501 gtccggagac ggccaagtaa catttggtca ggctgttgtc atgaaacaca cggcacggaa 1600561 agtgagaaaa ctgtttaacg gcaaagttct tgctggtttt gcgggatctg ttgcagacgc 1600621 tttcacttta ttcgaaaagt ttgaagctaa gcttgaagaa tataacggca acttaaaacg 1600681 ggcggctgtt gagcttgcaa aggaatggcg cagtgataaa gtgctaagaa agctcgaagc 1600741 catgctgatt gttatgaatc aggatacttt gcttctcgta tcgggaacag gcgaggtgat 1600801 cgaaccagat gacggcattc tcgcgattgg atcaggaggc aattacgctt tggcagcggg 1600861 aagagcactg aaaaagcatg ccggggaaag catgtctgca agtgagattg ccagagccgc 1600921 gttagaaaca gcaggcgaaa tttgtgttta cacgaacgat caaatcatac tggaagagct 1600981 tgaatagaaa ggacttgagg cgcatggaaa aaaaaccgtt aactcctaga cagattgtag 1601041 atcggttaga ccaatatatt gtcggtcagc aaaatgcgaa aaaagctgtc gccgtggcat 1601101 taagaaaccg ctatagaaga agtcttctgg atgaaaagct gaaggacgag gtcgttccga 1601161 aaaacatttt aatgatgggt cctaccggcg tcgggaaaac tgaaattgcc agacgaatcg 1601221 ctaagctttc aggtgcgcca tttatcaaaa ttgaagctac taaatttacc gaagtcggct 1601281 atgtaggcag agatgttgaa tcaatggtca gagatcttgt ggagacttct gttcggctta 1601341 taaaagaaga gaaaatgaat gaagtaaagg aacaggcaga agaaaatgca aacaaacgca 1601401 ttgttcgtct gttagttcct gggaagaaaa aacaatctgg tgttaaaaat ccgtttgaaa 1601461 tgttttttgg aggcagccag ccgaatggtg aagatgaggc ggagagccag gaagaagcaa 1601521 acatcgaaga aaaaagaaaa cgaatggcgc atcagctggc tttaggagag ctcgaagact 1601581 actatgtaac agtagaagtc gaagaacagc agccttctat gtttgacatg ctgcagggct 1601641 cgggtatgga gcagatgggt atgaacatgc aggatgcgct gagcggatta atgccaaaga 1601701 aaaagaagcg gcgcaaaatg acagtcagag aagccagaaa agtcctgacg aatgaagaag 1601761 caagcaaact catcgatatg gatgaagtcg gccaggaagc tgttcagaga gcagaagaga 1601821 gcgggattat ctttatcgat gagattgata aaatcgcaaa gaacggcggt gcatcttctt 1601881 ctgccgatgt ttcaagagaa ggtgttcagc gggatatcct tccgattgtt gaaggttcta 1601941 ccgttgtcac aaaatatggt tctgtaaaaa cagaccatgt attatttatt gcagcaggag 1602001 cgtttcatat ggccaaaccg tctgatttga ttcctgagct gcaggggcgt ttcccgattc 1602061 gtgtagaact gaacaaactc acggtagacg acttcgtgag aattttggtt gagccggata 1602121 atgcgctgct gaaacaatat caggcattat tgcagacaga aggtatatct cttgaatttt 1602181 ctgacgaagc tattcataag attgctgaag ttgcttatca tgtgaaccag gacacagata 1602241 atatcggtgc gagacgcctt catacaatac ttgaacgcct attagaagat ttgtcgtttg 1602301 aagctccaga tgtaacgatg gagaaaataa cgattacacc acagtatgtc gaagaaaagc 1602361 tcggaacgat agccaaaaac aaagatttaa gtcaatttat attgtgaaaa atttaatatg 1602421 aggaatgttt aggaggatta tttatcatgg ctttattaca aaaaacaaga attattaact 1602481 ccatgctgca agctgcggca gggaaaccgg taaacttcaa ggaaatggcg gagacgctgc 1602541 gggatgtaat tgattccaat attttcgttg taagccgcag agggaaactc cttgggtatt 1602601 caattaacca gcaaattgaa aatgatcgta tgaaaaaaat gcttgaggat cgtcaattcc 1602661 ctgaagaata tacgaaaaat ctgtttaatg tccctgaaac atcttctaac ttggatatta 1602721 atagtgaata tactgctttc cctgttgaga acagagacct gtttcaagct ggtttaacaa 1602781 caattgtgcc gatcatcgga ggcggggaaa gattaggaac acttattctt tcgcgtttac 1602841 aagatcaatt caatgacgat gacttaattc tagctgaata cggcgcaaca gttgtcggaa 1602901 tggaaatcct aagagaaaaa gcagaagaaa ttgaagagga agcaagaagc aaagctgtcg 1602961 tacaaatggc tatcagctcg ctttcttaca gtgagcttga agcaattgag cacatttttg 1603021 aggagcttga cggaaatgaa ggtcttcttg ttgcaagtaa aattgctgac cgtgtcggca 1603081 ttacccgttc tgttattgtg aacgcactca gaaagctgga gagcgccggt gttatcgagt 1603141 ctagatcatt aggaatgaaa ggtacttata tcaaggtact aaacaacaaa ttcctaattg 1603201 aattagaaaa tctaaaatct cattaatcac aaaaagaacc ctttttgagg gttctttttt 1603261 tatttcaaat aaaggaaatc aataagcttt atttcctggg ttgaaagtct ttctatgtaa 1603321 taattttaat aaattttgca tttttcttca aaaagtttca aaaatgccga aaagaaagga 1603381 gaaaaaacag aaattctgct attttcaggc ttatatcaag gcgagaaatg tagttctaac 1603441 aatctaggac tttataccta gttgcaaaat agataattgt gaggacattt ttttacacga 1603501 acttcataga ctttatgcct gttatttctt acaataagca tatagtttta caattctcga 1603561 caaggatatt gagggtgaaa aaaactgaaa tggaggtaag tggatttgag cttattttct 1603621 ggaacgatac aaaatcttga aaatgccttg agcagagcgg atattaagca aaaagtcata 1603681 actaataata tcgccaatat agatacaccg aactataagg caaaaaaagt ctctttccaa 1603741 aatttattag atcaagaatc ctcgcgtctt gaagcgataa aaacagacta tcgtcatgtt 1603801 gatttttctg atactgattc gaattattca attgttgcga gcggagatac atcgtatcag 1603861 caaaacggaa acaatgttga tgttgacaaa gagatgacag aattggcgca aaatcaaatc 1603921 aactatcaag ctttggttga aagaatgaac ggtaaattta attcgctgaa gaccgtatta 1603981 acaggaggaa aatgatgaca gcttttcata gcttaaatgt ttcagcatcg gctttaacag 1604041 ctcagcgagt cagaatggac gttgtatcat ctaacttagc aaatatggat acgacaagag 1604101 ctaagcaggt gaatggagag tgggtgcctt acagaagaaa aatggtttcc cttcagtcaa 1604161 aaggtgaatc gttctcttcc attctcaatt ctcaaatgag cggaagcggg aatgctggaa 1604221 acggtgtgaa ggtttcaaaa attacggagg atgattcgga ttttaatctt gtctatgatc 1604281 cgacagaccc tgatgcaaac gctgaaggat atgtacaaaa gcctaatgtt gatccattaa 1604341 aggaaatggt tgatcttgtc agcagcacta gatcatacga ggcgaatgtc acggcgatga 1604401 atgccacaaa gggaatgctg atgaaggcgt tagaaatcgg aaagtaggtg aatgaatgtg 1604461 attaatgcaa tttctccttt tcaggttcaa aatactcaaa acactcaaaa tgcaacaaat 1604521 caagtaaaca atagccaaaa aacagattct tcaaatcaaa caagcttttc ggagctttta 1604581 aaaaactcta ttagttcgtt aaatgagtcc caagtagctt ctgacaacat gactaatgcc 1604641 ttggctgcag gaaaagatgt aaatcttgat gaggtcatga tcgctgctca aaaagctagc 1604701 atctctctaa ctgcagcaac agagttccgc aataaagctg tggaagctta tcaggagatt 1604761 atgagaatgc aaatgtaggg ggtctgacga tttagagaaa gagtggaatg accgggggtt 1604821 aacatgaatc gtactctaat gcaaatgaaa aacaaaacga gtgagttttg gaaaaataga 1604881 tctaaattac aaaagatttt aatggttagt gctttagcgg caattattat tattggaatt 1604941 attattagtg tttttgcttc aaattctaaa atggcgccgc tgtacaaaga tttgtctgcc 1605001 gaagaagcag gacaaatcaa agaagaattg gatgcaaaaa aagtgccaaa cgaactttcg 1605061 aatggcggta cagtgattag tgttccggag gatcaggttg attctttgaa agtgcagatg 1605121 gctgcagaag gacttcctaa aacgggatca attgattatt cgttttttgg acagaatgcc 1605181 ggctttggtt tgacagacaa tgagtttgat atggtgaaag tgaaagctac acagacagaa 1605241 ctgtcaaact tgatcaatga aatggacggt attaaaaatt caaaagtaat gattaatctc 1605301 ccgaaagacg ctgtgtttgt cggtgaagag caatctgcag catctgcatc aatcgttttg 1605361 cagattcaac cgggttatac acttgatcaa agccaaatca acggattata tcatctggta 1605421 tctaaaagcg tgccaaacct aaaagaagat aacatcgtca tcatggacca aaattctaca 1605481 tactacgaca aatcagacag cgatgcaggg tcctacgcgg atagttattc ttctcagcaa 1605541 ggaattaagt ctcaagttga aaaagacatt caaaaacatg tacagtcact gctgggtacg 1605601 atgatgggcc aagataaagt cgttgtctcc gttacagcag acattgattt cacaaaagaa 1605661 aatcggacag aagacattgt cgaacctgtg gataaagaaa acatggaagg cattgcagtc 1605721 agcgctgaaa aggtatctga aacatatcag ggcgacggtg cagccaacgg cggaactgcc 1605781 ggaaccggcg aggaagatgt tacaaattat aaggctgacg gtgaaaatac cgaaagcggg 1605841 aactacgaaa aaaacagcaa caaaatcaat tacgaggtta accgaattca taaagaaatc 1605901 gctgaaagtc cttataaggt cagagattta gggattcaag taatggtaga gccgcctgat 1605961 gccaaaaaca ctgcgtcgct atcaactgaa agacaggatg atatacaaaa aatcctttca 1606021 actgtagtca gaacatcttt ggataaagat gaaacgcaaa atcagaattt atctgatgct 1606081 gatatcaata ataagattgt tgtttccgtt cagccattcg acggaaaagt caatttggat 1606141 acaaatacgg aagaatcctc aggtatcccg ctgtgggcat atattgtagg cggtgtttta 1606201 atcgcagcga tcattgttct gatcattatg cttatcagaa agaaacgggc gcaagaggat 1606261 gaatttgagg aatatgagta tgaggttcct caagaaccaa tcaatttgcc tgatatcaac 1606321 gaagaggaaa atgaaacagc ggaatcagtc agacgaaaac agcttgaaaa gatggcgaaa 1606381 gacaagccgg aagattttgc aaaactgctg agaagctggc tggccgagga ttaggaggaa 1606441 ttagaaatgg cgagacgtga tcaagataag cttacaggaa aacaaaaagc agccattctc 1606501 atgatttcct tggggttaga tgtgtcagct tctgtctata agcacttaac cgatgaagaa 1606561 attgaaaggc ttactctgga aatatcaggt gttcgaagcg tcgatcatca aaaaaaggat 1606621 gaaatcatag aagaatttca taatatagcc attgcgcaag attatatttc tcaaggcggt 1606681 ttaagctatg caagacaagt tctggaaaag gcgcttggag aggataaggc ggagaacatt 1606741 ctaaacaggc tgacttcttc tttgcaggtt aaaccatttg attttgccag aaaagcggag 1606801 ccagaacaaa ttttgaattt tatccagcaa gagcatccgc agacgatggc gttaatcttg 1606861 tcttatttag atccagtgca ggccgggcaa attttatccg agctgaaccc tgaagtgcag 1606921 gctgaggttg cgagaagaat cgcggtcatg gatagaacgt ctccagaaat aattaacgag 1606981 gtagaacgga ttctggaaca aaaattatct tctgcattta ctcaggatta tacacaaaca 1607041 ggcggaattg aagctgttgt ggaagtgtta aacggggtag acagagggac agagaagacg 1607101 atcttggatt cattggaaat tcaggatccc gatcttgctg aagagattaa aaagcggatg 1607161 tttgtcttcg aagatattgt cacacttgat aaccgtgcaa ttcagagagt cattcgcgat 1607221 gttgagaacg acgatttgct cctttcatta aaggttgcaa gcgaggaagt caaagaaatt 1607281 gtgttcaaca atatgtcaca gcgtatggtt gaaaccttca aagaagaaat ggagtttatg 1607341 ggccctgtac gtttgaaaga tgtagaagaa gctcaatcaa gaattgtaag catcgtcaga 1607401 aagcttgaag aagccggtga aattgtaata gcaagaggcg gaggggatga tattattgtc 1607461 taatatcatt aaacaagaat catctatttc tccacaaaag gaaaaaagaa aactttctat 1607521 acaagaggtg cgtattgatc attctcacct tttgcaggct gaagagaacc cggaggcgct 1607581 tatggcccga gtgaaagagg aagctgaccg gatttctgag caggcaaaca gtcatataga 1607641 aaatattcgc cgtcaaattg aacaggagaa aaacgattgg gcggctgaaa aacagaagct 1607701 tattgaagaa gcaaaagccg agggctttga acaaggagta gcgctgggca aagctgaggc 1607761 aatgaaacag tatgcagaac tgatcggcca agcaaacagt ataactgaaa tgtccagaaa 1607821 agctgttgag gacaagcttg aagacgctaa tgaagaaatc gttgagcttg ccgttgccct 1607881 agcaaaaaaa gtttggcagc aaaagtctga tgataaagag gctttcctcc tgcttgtaca 1607941 acaggttata aacgaagtga aggaatatga cgatatatca atttatgttg atccatatta 1608001 ctatgagaca atctttcagc aaaaagatga aatccagcag cttctttata aagaatgtcg 1608061 gcttggcata tatgctgatg aaaaagctca aaaaggaacc tgttatattg aaactccttt 1608121 tggcagggta gatgcgagtg ttgacacaca attgatgcaa ttgaaagata aacttctgac 1608181 agcgctggaa gcaggtgcag ctgaatgaag acacagagtc tgatagattg tatagaaatg 1608241 acagactcgt ataaacggta cggaaaagtc aagcgggtaa tcggcttgat gattgaatca 1608301 aaagggccag caagctcaat tggtgacctg tgcctgattt atgcaaaagg acagtctggg 1608361 aaagtcatta aagctgaggt agtcggcttc caggaagaaa atattttgct tatgccttat 1608421 ttagaggctg cgagcattgc acctggcagc attgtagaag ctactgggga atcacttcgg 1608481 gttaaagttg ggaccggact gatcggacaa gtcatcgatg cttttggaga accgcttgac 1608541 ggaaagcttc tgccgaaagg gctttcgcct gtatcaacgg agcaatcacc gcctaacccg 1608601 atgaaacggc cgcctatccg tgaaaagatg ggtgttggag tcagatcaat tgacagcttg 1608661 ctgacagtcg gtaaaggcca gcggattgga atttttgcag gaagcggtgt cggaaaaagc 1608721 accttaatgg ggatgatcgc caagcagaca gaggctgact taaacgtcat tgcacttgtc 1608781 ggagaacgcg gacgagaggt tcgggagttt attgaaaaag atctggggaa agaggggctg 1608841 aaacgatcga ttgtagtcgt tgccacctca gaccagccag cattaatgag attgaaagcg 1608901 gcatatacag cgactgcaat tgccgagtat ttccgagata aaggccaaaa tgtcatgttt 1608961 atgatggatt ctgttacaag ggtggcaatg gcgcagcgag agattggact ggctgcagga 1609021 gagcctccga cgacaaaagg ctatacacct tcagtgttcg ctattttacc tcgtttacta 1609081 gaacgaacag gtgcaaacga gcatggaacc attacggcat tttatacagt gttggtagat 1609141 ggggatgaca tgaatgagcc gattgccgat accgtacgcg gaattttaga cgggcatatt 1609201 gtgttggaca gggcgcttgc caataaaggc cagtttcctg cagttaacgt actaaaaagc 1609261 atcagcaggg tgatgtcaaa catttcaaca aaacagcatc tggatgcggc aaataaattc 1609321 cgtgaacttt tatcgacata tcaaaattcg gaagatctca ttaatatcgg agcttacaaa 1609381 agaggatcat ccagagaaat tgatgaagcg atacaatttt atccgcagct tattcaattt 1609441 ttaaagcagg gaacagacga accggcttta ttggaagaaa gcattgctgc attaactagt 1609501 ttgacaggaa atgaggaata aacgtggctt atcaatttag attccaaaag ctgctggaac 1609561 taaaagaaaa tgaaaaagac caatccttat ccgaatatca gcaatcagtt tctgaatttg 1609621 aaaacgttgc tgaaaaatta tatgagaata tgagcaaaaa ggaattgctg gaacaaaata 1609681 aggaaaagaa attaaaaagc ggcatgagtg tacaagaaat gaggcactac caacaatttg 1609741 tctcaaatct tgataatacg atctatcact atcaaaagct tgtcattatg aaaagaaatc 1609801 aaatgaatca aaaacaagaa attttgacag agaaaaacat tgaagtgaaa aagtttgaaa 1609861 aaatgcgtga aaaacagttt aaaatgtttg ctcttgaaga taaagctgca gaaatgaaag 1609921 aaatggacga tatttcgatt aagcagttta tgattcaagg ccattaggag cgaatgtaat 1609981 gtccggcaaa aagaaagaat caggtaagtt ccgttcggtt ttgcttatca ttatcctccc 1610041 gctgatgttt ctattaatcg caggggggat tgttctttgg gctgctggta tcaatgtctt 1610101 aaagccgata caggatgctg cggcaaaaac gccggttctt aaagaattgg tccctgaaac 1610161 cgaaaataaa aaaggcgcag catcaagtaa ggatagcagt aatacggcag ctctggaaaa 1610221 gaccattaag gatcaaaaaa gtgaaatcag tatattgaat aaagatttag aaacaagtaa 1610281 atcagaaatc gacaggctca atcaaaagat ccgttcactt gaaaagacgg ctgaggatca 1610341 aaaaaagtca tcagaagatc atactgaagg atcagcagac tcgaaagctt cttctgaaaa 1610401 tgacaaagtg atcagtgtgt acaaaagcat ggacagcgga aaggctgcta aaattattgc 1610461 ccaattaaag gagcaagaag cactgaaaat attgaatggc ctaagcaaaa agcagcttgc 1610521 tgacatattg gcgaaaatga ctcctgagca agcagcaacc tatacagaaa aaattgctgc 1610581 cagccaagaa tagggggaat gaaaggtgaa gctgcttgaa ttagccggac ctttgctgca 1610641 aaccacaacg ggttctgccg ctaaaaacat gaaaagtagc cagggagttt ttcaaaactg 1610701 gcttatgtct gaggctggat tgaaggaact ttcagaacaa ggaaagggaa ctcctaattc 1610761 tgaagatcag cttttagcag atgcgcttaa aaagatcggt gaatggctaa atgcaagtcc 1610821 tgaagatcaa gacaaacaaa atgcggatct tttgcaaaca ttaagcaaac tgacagggaa 1610881 gcaattggat gcgaatgctc tgcaaatgtt gcaaaatctt ttgcaagcag ttgaatcaaa 1610941 aatgtcaggc gggacggatc aattgctcac agaaacggag aaaatctttt cagaagctaa 1611001 aacggctctg agtgccaatg attctgcttc tgacattaat ggagcactga agtctgataa 1611061 agagcaatca aatcaggaaa atgaagtatc cgagcctgca aaagagctta tctatatcca 1611121 gatgttcatt agccagctcg tagaagggaa taagctgact gatctcggga atggcaatga 1611181 agctcatgcc atttaccaaa atggagatca attcctttct gcattagaaa agaagggtgt 1611241 atctcaacaa ctaattcagg atcttaaaca gcaaatattc actaaagctg agtcaagttc 1611301 aaaactttac tcgatgacag cgtcagagct gaaaagtttt caaagcttaa tggatcaaat 1611361 gtctatgctt cctcaaaaag ggaccaaaga atggagttta gctgaaagcc agctgaaagc 1611421 cttcttgtta tcgaaatcat ccgaatcatc acaagacttt gggaagagtg ttctcacacc 1611481 gctctcgcag agttcatcca gcaaaaatgc atcggatgtt tctggaagta ttcagcctgt 1611541 agatagtaaa tcaggactcc aaatgctgtt ttcggggtat cggggcatag gaggagttca 1611601 aacacttgat ctgcagcaga tgtcatctga tataccaaat gccgaaacaa aaacggtggc 1611661 tgatcaagtg attaatgcgt ggaagcagat gaaatatacg cctttcggca gatcgacggg 1611721 aagtttcact attcggctga accctgaaca tttaggattt gtcacaatca agctgacaaa 1611781 tgaaaatgga atgtttcaga gtaaaatcat agcatctagc caatcagcaa aagaattgct 1611841 tgaacagcat cttcctcagc tgaagcaatc attgccgaat atggccgtcc aaattgaccg 1611901 ttttactctt ccggtccaaa gcggggatca gccgatatac ggccagcttg ctgatgaaca 1611961 gaaacagcag caagaggggc agagacagca aagacagaaa aagcaatcaa atgattttgg 1612021 cgatctgctc gatgaagtgt cgatggttga aatggaggaa gaagaatgac ttctataagt 1612081 tcagaatata aactgcctga aaaaacgaac actgtgtcga cgaacaacag cagcttgggg 1612141 aaagacgagt ttttaaaaat attaatgact caagttcaaa accaagatcc gcttaacccg 1612201 attgacgata aagaatttat cagccagatg gcgacttttt caagcttgga gcaaatgatg 1612261 aatctgaata cgacaatgac tcaattcgtt gaaaaccaag atccgtttac aacgtatgtt 1612321 gattggatgg gaaaagaagt atcttggact gatggtaaaa gtgcaacaga taaaacaggc 1612381 acagtaagct ctgttaaaca ttttaaagga aattattatc tcgttcttga tgatgggacc 1612441 gagatcagtc ctgcgaatgt catgtctgtg ggacaatcat ctaaataaaa acatctgggg 1612501 gaatatatta tgttacgttc actttattct ggaatcagcg gtatgaaaaa ctttcaaaca 1612561 aagcttgacg taatcggtaa caacattgcc aacgtaaata cagtaggatt caaaaagagc 1612621 cgtgtgacct ttaaagatat ggtaagccaa acgattgccg gcggttctgc tgctggtgca 1612681 acaatcggcg gaacaaactc taagcaaatc ggtttaggtt catcatctgg cacaattgat 1612741 acaattcatt caacaagcgc gacacaaagc acaggaagaa cacttgattt agcaattgac 1612801 ggcgacggtt acttccgaat tgatacaggt gacgggacag cttatacaag agcagggaac 1612861 ttctatttag ataatactgg aacactggtt acaggtgatg gctaccatgt actaaatatg 1612921 aatggcggaa caattaaaat tcctactgat gctcaaagct ttagcattgg ttctgatgga 1612981 aaggtgtcaa ttgttgatgc tgaggggaaa acacaagacg ggggacaaat cgggattgtt 1613041 acttttgcca acagtgatgg attggataaa atcggaagca acctataccg tgaatcttta 1613101 aactctggaa cggccagtgc agcgaaccag cctggtgacg gcggaactgg tgctcttaaa 1613161 tcaggatttc tcgaaatgtc taacgtcgat ttaactgacg aatttactga aatgatcgta 1613221 gcccagcgcg gattccaatc aaactcaaaa attattacaa catctgatga aatccttcaa 1613281 gaactggtta accttaaacg ttaaggaggg aggggaggcg agtaatcgct tctccgctgt 1613341 tttatgatta aagtaacccg tttgaacggg cagcccttta cactgaatgc gctatttatt 1613401 gaacagattg aatgttttcc ggatactaca attactctgt caaatggtaa gaagtttgta 1613461 gtaaaagaag atgaagaagc tgttctggaa aagatcgcag ctttctaccg aaaaatacaa 1613521 atatttgcaa tggatcaagg aatagaggaa ccggaatgaa gaaaaagtta atgatcatat 1613581 tactaattat tcttatcgta attggtgctc tcggggcggc ggcttatttt gttttaggcg 1613641 gaaagtccga aaaaagtgaa gcgaaaaaaa gtattgatga aatcgttgcg tcttctgttg 1613701 atgtagaaga gatcacaaca aatttaaagt ctgataacat tatccgtctt gctattaaac 1613761 ttgaaactga ttctgataaa tcaaaagaag aacttgagaa acgtgatttc caagtgaaag 1613821 acgctgttat atcactgctg gctgatacga atgctgatca gattgaggga gacaagggaa 1613881 aagaaacctt taagaaggaa ctaaaagata aaataaatag ctacctccaa gaaggaaaag 1613941 tagaaaaagt gtatattacc tcctttaatc tgcaataaag cataatttga cagaatacgg 1614001 aggtgaggaa aatgtcagga gaagttctct cccaaaatga aatagatgca ctgctctctg 1614061 caatatcaac tggtgaaatg gacgctgaag agctgaaaaa agaagaaaaa gagaagaaag 1614121 tcaaggttta tgatttcaaa cgtgcgctgc ggttttctaa ggatcagatc cgcagtttaa 1614181 cgagaattca tgacaatttt gcaagacttc ttaccactca tttttctgct cagctcagaa 1614241 cctatattca catatctgtc agttctgttg atcaggttcc gtatgaggaa tttatcagat 1614301 cgattccaaa catgacgatt ctgaatctat ttgatgttca tccgatggaa ggaagaatta 1614361 tgatggaggt caaccccacg atagcttata cgatgatgga tcgagtcatg ggcgggattg 1614421 gaatcagtca taacaaggtt gacagtttga cagaaattga aacaaaaatc atttctaatt 1614481 tatttgaaaa tgcactgggt aattataaag aagcttggca gtcaattgct gatattgaac 1614541 cggaaatgac tgagtttgaa gtgaatccgc aatttgttca gatggtatct cctaatgaaa 1614601 cagtcgtggt gatctcgctc aatactcaaa ttggtgaaat cagcggtgtc attaatctct 1614661 gtatcccgca tattgtactc gagccgctca taccgaagct ttcagtccac tattggatgc 1614721 aatcagaccg aaatgagcca aagcctgagg aaacaaagtc gcttgaaaaa cgtatcatga 1614781 cagcacaaat acctgtcgtg gccgagctcg gcacatctga actgacgata gaagagtttt 1614841 taagtttaga agtcggagac tgcataactt tggacaaatc agtcacggat cctcttactg 1614901 tattggtcgg agataagccg aaatttttag gacaagccgg ccgggtgaat cgaaaacagg 1614961 cagtgcaaat tttagatcac gacataagag gtgaacaaga tggagaataa tagattatct 1615021 caagatgaga ttgacgcgct tcttaacggt actggcagca cgcttgatga gccagagatt 1615081 ccggaagtag atgacttatc ggaaatggag cgtgatgcga tcggtgaaat cggtaatatt 1615141 tcattcggca gttctgcgac agcactgtca acgcttttaa atcaaaaggt cgatattacg 1615201 actccaagcg taacggtcat tccaagaagt aaaatcagcg atgcgtttcc tgaaccgtat 1615261 gtagcgattg aagtgaatta tacggagggc ttcagcggaa gcaacctgtt agtcgtggaa 1615321 caaagtgacg cggcgatcat tgcggactta atgatcgggg gagacggaaa aggtgcggac 1615381 ccttcactgg gtgaaatcca tttaagtgcg gttcaagaag caatgaacca aatgatggga 1615441 tcggctgcca catcaatgtc tactgtattc agtaaaaaaa ttgatatttc acctcctcgg 1615501 gttgaattgc tggatgttac tgaagaaaag ggtacagacc gtattcctga tgatgaaatg 1615561 ctggtgaaag tttctttcaa cttaaaggtg ggagaattaa tagactccag cattatgcaa 1615621 ctttacccat tgacatttgc gaaagattta atttcaagcc ttatgaactc agaaagtgca 1615681 gaggaagaag aaacggtgca gcctgaagtt acatacgaac agccgaaaga gcctgtgacg 1615741 ccagagccgc gtattgaacc gaagcaacag cagcagccgc caaaaaggca gggaacagca 1615801 aaaaaagcag cgccagttca ggtttcaccg gtggaatttt ccgcgtttga tccaaacgaa 1615861 gctgtacaag cccctattca taatctggat atgcttttgg atatcccgct ttcgattact 1615921 gttgagcttg gcagaacgaa gagaagcgta aaagagattt tagagctttc tgccggaagt 1615981 attatcgagc ttgataaatt agccggtgag cctgtagata ttttagttaa tcagcgtatc 1616041 gttgccaaag gcgaggtcgt tgtcattgaa gaaaacttcg gagtgagagt cactgacatt 1616101 ttaagccagg cagagcgcat taataattta aaataacgaa acacaaggag agagatagat 1616161 tatggcacat agaattttaa ttgtagatga cgcagcattt atgcgaatga tgattaaaga 1616221 tattttggtt aaaaatggtt ttgaagttgt ggcggaagct gaaaatggag cacaagcggt 1616281 agagaaatat aaagagcatt cacctgacct tgttactatg gatatcacga tgccagaaat 1616341 ggatggtatt acagcattaa aagaaattaa acaaattgat gcgcaggcaa gaatcatcat 1616401 gtgttctgct atgggacagc aatcaatggt tattgatgcc attcaggccg gcgctaagga 1616461 tttcattgtg aaacctttcc aggctgaccg tgtgcttgaa gcaatcaaca aaacattaaa 1616521 ttaaagggtg tacgactgtt gaaaaagagt caatatttta ttgtttttat ttgttttttc 1616581 gttttattca gtgtacatcc gattgctgct gccgcggcag actctgataa ttcaactgta 1616641 aacgaatggt ttcaaaagaa agatgaaaaa actgcagatc aatcagagca aaagaaagaa 1616701 aaaacaacaa aaactgctga tgagacggag ggagcggctg ctccttctgt ctcagctttt 1616761 gattttgtaa agatgatttt cgctttactg tttgttatcg tgctgattta cgggctggtt 1616821 aagctcatga acaaaagaaa tcggctccta aagccttttc aatatgttga aaatattggc 1616881 ggcacatcgg tcggtcagaa cagatccata caattgatca aggtcgggaa aagtgtgctc 1616941 gtcgtcggtg taggagagac gatccagctg ctgaaagaaa ttgaggatga aaaagagatt 1617001 gaagtcattc tcagtcagca tgaagaggca atgtcaagca aaatagagtg gcaaaagttt 1617061 gtgaagccgc ttaagagttc tgaacatcag ccgcagcaaa aactgccttc attttcaaaa 1617121 gcattaaaag agcaacttga agagttaaaa caaaaccgtt ctgaaggaaa gaagaaaggc 1617181 ccacgtcatc atgaatgagt ttataaatat tttcagttca agcgatccgg aaaacgtaag 1617241 ttcgactgtt aaattactat tattgttaac tgtattttca gtggcgcctg gaatattgat 1617301 tcttatgact tgttttactc gcatcgtcat tgttctgtca tttgtcagaa cttcacttgc 1617361 gacgcaatct atgcccccaa accaggttct aatcgggctt gcgctgtttt taacattttt 1617421 tattatggct cctacttttt cagaaattaa taaagaagcg ctgaccccat taatggacaa 1617481 caaaatcagc ttggatgaag cgtatacgaa agctgaggaa ccgattaaag aatttatgag 1617541 taaacacaca aggcagaagg atctggcgct gtttatgaat tacgcgaaaa tggataaacc 1617601 tgaatcatta aaggatattc cgttaacaac aatggttccg gcttttgcca tatcggagct 1617661 taaaacagca tttcaaatag gttttatgat ttttatccct tttttaatta tagatatggt 1617721 agtggcgagc gtcttgatgt caatgggaat gatgatgctg cctccagtta tgatttctct 1617781 gccctttaaa atattacttt ttgttttggt agacggctgg tatttaattg tgaaatcttt 1617841 gcttcagagc ttttagggta ggtgctaaac gtgagttcag aatttgtaat ttctatggcg 1617901 gaaaaagccg tatacgtaac gctgatgatc agcgggccat tattggctat tgctttactg 1617961 gtcggtttaa ttgtcagcat atttcaggcg acaactcaaa tccaggaaca gactttggcg 1618021 tttattccga aaatcgtggc ggttctcctg gctctcattt tttttggtcc gtggatgctg 1618081 tcgacgattc tttcatttac aacagagctg ttttctaatt taaatcgttt tgcagggtaa 1618141 tgtagagatg aattcaatta ttgacttatt tcctgctttt ttattggttt ttattagaat 1618201 ctctgctttt tttgtaacga ttccgctatt tggacatcga aatgtgccag ctgttcatcg 1618261 cataggtttt gctttttttc ttgcggtcat ttgtttcagc accattgata aaccgccctc 1618321 tttggagata gatgagcact atatgctttt ggcgtttaaa gaagctttgg tcggcctatg 1618381 tctgggttta attgcttata tgatgattgc cgcagtgcag attgccggct cgtttattga 1618441 ttttcaaatg ggattttcaa tagcaaacgt tattgatccg caaaccggtg cacaaagtcc 1618501 gttgattggc cagtttatct atacgatggc acttttgttt atgctgagtg tcaatgccca 1618561 ccatttgttg ctggatggta tttactacag ctttcagtat atttcagttg atcaggcatt 1618621 tccgaatttc ggcgatgaaa agtttgccta ttttattgcg aaaagcttta atgcaatgtt 1618681 tattatcgct tttcaaatgt cagcgccggt tgtggccagt ttgtttctag ttgatttagc 1618741 attaggtatc gtggctcgaa ctgttccgca gttaaatgta tttgtggtcg gtctgccttt 1618801 aaagatcgct gtcagtttca ttatgctcat tgtatgtatg tccgttatct tcgtcgttgt 1618861 ccggaatgtt ttcagtttaa cgattgaaac gatgcggaat cttttagcat tggtcggtgt 1618921 ttcttaatga agcttagagt tgacctgcag ttttttgcgg gagagaagac agaaaaagcc 1618981 actccgaaaa aacggaagga tacgcgaaaa aaagggcagg tagccaaaag ctcggatgtc 1619041 aataccgccg tttctttact ggtaatattc ctttcgctta ttgcaattgg tccgtatatg 1619101 agagacaggc tgctgtcatt catagaaaca ttttataccg aatcgctcac aatgaagctc 1619161 tcagaatcaa atgtgcatac attgtttgtc agcttattaa aggatatggg catgatactc 1619221 gcaccgatct tgcttgttgc tcttgttgca ggagtcgtaa gcaactatat gcaggttggg 1619281 ttcttgtttt ctgctgaagt gatacagcct aagcttgaaa aactggatcc gatcaaaggc 1619341 tttaaacgaa tatacagtat gagggcgatt gtagagctga ttaaatcaat tttgaaaatc 1619401 gtagtcgtcg gttttgcggc ttttgctgtg ctttggctgc attatggaga aattctccgg 1619461 cttcctctcc tgacacccga agaggcactt tctttcgttt caaaactcac tttgtggatg 1619521 ggactaagcg gtgcaggtgc attgttgatt cttgctggtc tcgactattt atatcagaga 1619581 tttgactatg agaaaaatat caaaatgtca aaacaagata taaaagatga gtacaaaaaa 1619641 tctgaaggag acccgattat caagtctaaa attaaacaaa gacagcggga aatggcgatg 1619701 aggcggatga tgcaggaagt tccaaaagca gatgtcatta tcacaaaccc gactcactat 1619761 gcgattgctt tgaaatatga tgaagaaaaa atggacgcac cttatattgt tgcaaaaggc 1619821 gtcgaccacc ttgcgttaaa aatcaggaaa attgctaaag agcatgatgt catgatggta 1619881 gaaaacagac cgcttgcccg tgcgttatat gatcaagtgg aaattgacca ggcagtgccg 1619941 gaagaatttt ttaaagtttt agcagaaatt ctggcttacg tatataaaac aaaacaaaaa 1620001 gtatattgaa tttttcgatt taaaaggaga gaaaaaacag catgtcaaca agagatttat 1620061 ccgttttaat aagtgttgtc ctcattgtgg cgatgctggt gattccattt cctccatggc 1620121 tgttaagtat tttgatcatt attaatattt ctcttgcgtt gatcgtgctt ctcaccacaa 1620181 tgaatatgca ggaagcgctt cagttttcga tttttccgtc actgttgctg cttttgaccc 1620241 tatttcgttt gggcttgaac gtctcaacta cccgttcaat tctttcacac ggtgagggag 1620301 gtaaagtcgt cgagactttc ggaaatttcg ttgtcggcgg aaatgtatta gttggactcg 1620361 ttgtatttat catccttatt attattcagt ttatcgtcat tacaaaaggt gctgaacgtg 1620421 tttccgaggt tgcagcaagg tttacgctgg acgcaatgcc ggggaagcag atgagtattg 1620481 atgctgattt aaacgcaggg atgattaccg aacaggaagc gaagcatcgc cgcgaaaaag 1620541 tggcaagaga agcagacttt tatggagcaa tggacggtgc cagtaaattt gtaaaaggtg 1620601 acgccattgc cggaatcatc attgtgatga tcaatattat tttcggaatc gtgatcggaa 1620661 tgcttcagca gggcatgtcc attcaagaag ctgcttcaca ctttacgatg ctgactgtag 1620721 gggatggaat tgtttcgcaa atcccggcac tgttaatttc tacggctacg ggtattgtgg 1620781 tcacaagagc tgcatctgaa ggaaacttag ggcatgacat tacaggccag ctgtttgcgt 1620841 atccaaagct tttatacgtc gcagcagcta cgatcatgct tttaggtatt ttcactccga 1620901 tcggcatcct tctgacgggg ccgcttgcgg gattgcttgc ttttggcgca tatacactat 1620961 ctaaatcagg taaggaaaaa gaagaagtgg atgagattct tgaggaagag gctgaggtgg 1621021 acgagcttaa aagccctgaa agtgttgttc agcttctgca tatagatccg atagaatttg 1621081 agtttggata tggcctgata ccgcttgctg atgccaatca aggcggtgat ttattagacc 1621141 gaattgttat gatacgccgt cagttggctt tggaactcgg gcttgtcatt cctgtcgtgc 1621201 gaatcagaga taatatagcg ttgcagccta atgaataccg attgaaaatt aaaggaaacg 1621261 aagtagcaaa aggcgagctg ttgcttgatc attatttagc gatgtcgcct actcctgagg 1621321 acgatctcat tgaagggatt gaaacagtgg agccttcatt cggactgccg gctaaatgga 1621381 ttagcgaagc ggtaaaggat gaagccgaca tgcttggtta tacagtagtt gatcctgcat 1621441 cagtcgtttc aacgcatatt acggagaaaa ttaagcagca tgcccacgaa ttgatcggaa 1621501 ggcaggagac aaaacagctg atcgatcact tgaaagaatc gtatccagtc ctggttgaag 1621561 aggttacgcc gaatccattg tctgtcggtg atattcagaa agtgcttgct aagcttttaa 1621621 aagaaaaagt ttcaattcga aacttagtaa cgatttttga aacacttgct gactatggga 1621681 aattaacaac agattctgat ctcttgacag agtatacaag acaagcgctt gctaaacaaa 1621741 ttacagccca gtttgccaaa gaaaatgaag tgttgaaggt tgttacttgt tccggccgtg 1621801 tagaaaaagc aatagcagac ggtgtgcagc agacggaaca cgggaactat ttatcacttg 1621861 aaccagatat ttcagaaagt atagtgcgct ctgtcgccaa agaagctgaa cagctctcat 1621921 tacgtcagga aaccgcgatt cttctttgct cgccgcctgt cagaatgtat gtgaagcagc 1621981 tactggaacg gtacttccct gatcttccgg tactctctta taacgaactt gaggcgaatg 1622041 ttgaggtaca aagcattgga gtggtggata tttaatgaaa ataaaaaaat ttactgctgc 1622101 ttcaatgcaa gaagcggcac ttctcatcag aaaagagtta ggtaatgaag cggtcatatt 1622161 aaattcgaaa aaaattaaaa agcgaaaatg gtttggcctc gtcaacaagc ctgctgttga 1622221 agtaatcgcc gtattggatc aggactttct tgagaaaaaa acgcctcaga aggcagctga 1622281 accgaaacaa acattaaaaa ctccggtcag cagtccaaaa atagaggaga gaacatatcc 1622341 ccctcaaatt ccggcgcaac aggagctagg tgatttttca gcatatcaat ctgtacttcc 1622401 tgagccgctg cgaaaagcag aaaagctttt gcaagaaaca gggatcaaag agtctacgaa 1622461 aacgaacact ctgaaaaaat tgcttcgctt ctctgttgaa gcaggcggct tgactgaaga 1622521 aaatgttgtc ggcaaacttc aggaaatact atgcgatatg ctgccctcag cagacaagtg 1622581 gcaggagcca attcattcaa aatatatcgt tctctttggt tcaacagggg ctggtaaaac 1622641 aactacactg gctaaactcg cagccatatc tatgcttgaa aaacataaaa aaatcgcttt 1622701 tattacaaca gatacgtatc gtattgcagc tgttgaacag ttgaaaacat acgctgaact 1622761 gctgcaggct cctctggaag tttgctatac aaaagaagaa tttcagcagg cgaaggagct 1622821 attttctgag tatgatcatg tgtttgttga tacagctgga agaaacttca aagacccgca 1622881 atacattgat gaactgaaag aaacgattcc ttttgagagc agcattcagt catttcttgt 1622941 tttatccgcg actgcaaaat atgaagatat gaagcatatt gtcaaacggt tttcatccgt 1623001 ccctgtcaat cagtatattt ttacgaaaat agatgaaacg acttccttag gttctgtatt 1623061 taatatactg gcagaatcaa aaataggtgt cgggtttatg actaacggcc agaatgtgcc 1623121 tgaggatata cagactgtat ctccacttgg ttttgtgagg atgctgtgca gatgaacaga 1623181 tatgaccaag cagcaacttt acgggcgaaa atggaaaaac gtgagcgcgt tctgccaatg 1623241 gtttattcac aaaaagcgaa gacacttgct gtcatcagcg gcaagggcgg tgtcggaaaa 1623301 tccaatatta ccttaaatat ggcacttgcg ctgcaggata aaggtaagaa ggtgctgctc 1623361 atcgaccttg atatcgggat ggggaacatt gatatattaa taggaaattc atcgtctgcc 1623421 acgataatcg atgttttaac cgatcgtaag cctttgctgc agtcattatc cgttggccca 1623481 aagggtttgc ggtatatatc agggggaacc ggtcttgatg tgatgtttca gctcgatcag 1623541 agaaaatgga cgttttttgc caatgaactt tctcatgcat taagccagtt cgattatgtg 1623601 ctgtttgaca tgggagcagg cttatcaaaa gatcaactgc cttttatttt atcagcagaa 1623661 gatattttga ttattacaac tcccgagccg acggccatta tggacgcata cagcgctgtc 1623721 aagcacttgg ttttgacaga aaataagctt tcaatgaagg tggctgtcaa tcggtgccgt 1623781 gaccaaaagg aagggcttga cgcttttgcc cgcctctccc gtacaattca tatgtttttg 1623841 gatgttcagg ttcagtttgc cggttccgtt tctgacgatg tgatcgtgag caaagcggtt 1623901 gtcgaacagg ttcctttttt cataaaaagc cctcaggcaa aagccagccg gtcagtccgt 1623961 attttagcgg acgccttgtt tgaaagagaa gaaacgagac acaaagaaga caaacagaca 1624021 tttattgaga aattatcttc ttttttaatg aggagggctt aatttgattc gtgtgcttgt 1624081 agttgatgat tcagctttta tgagaaaaat gataagtgat tttctgaccg aagaaaagca 1624141 gatagaagta atcggaactg cgagaaacgg agaagaagcg cttaagaaga ttgaattatt 1624201 aaaaccggat gttattactc ttgatgttga aatgccggtc atgaatggga cagatacgct 1624261 ccgcaaaatt attgagattt ataacttgcc ggtcattatg gtgtctagcc agaccgagaa 1624321 aggtaaagaa tgcacaatta attgtttgga gatcggtgcc tttgacttta tcacaaagcc 1624381 atcaggctca atatctctgg atctatacaa aattaaagaa caactagttg agcgtgtcgt 1624441 cgcggcagga ctttccggca agcggaaacg tcctgtttcc cagacagttc ggcccgaacc 1624501 tattgtgcgt gctgtcgtta agcctgaatt aagcaaaccg aaacctggca cgggcagaca 1624561 aattgtgtgt atcggcacat caacaggcgg tccacgggcg ttacaaaagg tgataccgaa 1624621 gctccctaag gatttgaacg caccagtggt tgtcgttcag cacatgcctg aagggtttac 1624681 tgcttctttg gctgatcggc tgaatcattt atctgacatt caggtaaaag aagcaaaaga 1624741 tggtgaagca gctcttaacg gctgtgttta catagcaccg ggcggaaaaa acatatccgt 1624801 tattaaaaac agcgaaggac tccaggttgt gcttgataac catgacacac caagccgtca 1624861 taaaccatct gctgattatt tattccgttc tgtcgggaaa ctgacagatt atgaaaaagt 1624921 agcggttatc atgaccggaa tgggcagtga cggcactgct ggactaaagg acatgctaac 1624981 agccggcaat gtgaaagcca ttgcggagtc tgaagaatct tgtgtcgtat acgggatgcc 1625041 aaaagctgct gttaaagcgg gtctcattca tgagattaaa catgtggaag atatcgcagc 1625101 atccatcaca agctgtgtga aaaaagagag ggtgtgattc aaatggatat gaatcagtat 1625161 ttagatgtct ttattgatga gagtaaagaa catttacaaa catgtaatga aaagcttctt 1625221 cttttagaga aagacccgac tgatcttcag ctcgtacatg atatattcag ggctgcccat 1625281 acattaaaag gaatgagcgc aacgatgggc tacacggatt tagcacatct tacccatctg 1625341 cttgaaaacg tgctggatgc aatccgaaac ggagacatgg aagtcacctc agactggctg 1625401 gatattttgt ttgaagctct ggatcacctg gaaacaatgg ttcagtctat tattgatggc 1625461 ggggatggta aaagagatat ctcagaagtg agtgccaagc ttgatgtgaa tggtgcgcac 1625521 gctgaatccg ctgcctccgc tgaacctgca gaagcacaga gttcagcatc tgattgggaa 1625581 tatgatgaat ttgaacgcac agttatacaa gaagcggagg agcaaggctt caaacgatat 1625641 gaaatcaaga tttctctgaa cgaaaactgt atgttaaaag cagttcgtgt ctatatggtg 1625701 tttgaaaaac taaatgaagt cggagaagta gccaaaacaa ttccaagtgc tgaagtgctt 1625761 gaaacagaag attttggaac tgactttcaa gtttgtttct taacacatca atcagcggaa 1625821 gacattgaac aattaatcaa tggcgtgtcg gaaattgagc atgttgaagt cattcaaggg 1625881 gctcctttaa catcagctga aaagcctgaa gaatctaagc aagaagattc accagcagca 1625941 gctgtacctg cgaagcagga gaaacaaaaa cagcctgcta aaaacgatga acaggcgaag 1626001 cattcagccg gcggatctaa aacaattcgt gtcaacattg acaggcttga ttctttaatg 1626061 aacttatttg aagagcttgt cattgaccgc gggcgtctcg agcagattgc gaaagagctt 1626121 gagcataatg aactgactga aacggttgaa cgaatgacga gaatttccgg agatttgcaa 1626181 tcgattattc tgaatatgag aatggtcccg gttgaaactg tttttaacag attcccgaga 1626241 atgattcgcc agcttcagaa agagctgaat aaaaaaattg aactctcgat catcggtgcg 1626301 gaaactgaac tggatcgtac agtaattgat gaaatcggag atccactcgt tcacttgatc 1626361 agaaacagta ttgaccatgg tatcgaggcg ccggaaacac gtttgcaaaa gggaaaaccg 1626421 gaatcaggaa aagttgtgct taaagcttat cacagcggca accatgtctt tatcgaagta 1626481 gaggatgacg gcgcaggcct taatcgaaaa aaaattctgg aaaaagcgct tgagcgcggg 1626541 gtcataacgg aaaaagaagc tgaaacctta gaagacaacc aaatttacga attgattttt 1626601 gctccggggt tctcaactgc tgaccaaatt tctgatattt ccggccgcgg tgtaggactt 1626661 gacgttgtaa aaaacaaact ggagtctctt ggcggttcag tcagtgtgaa atcagccgag 1626721 ggtcaaggct ctctattcag catccagctg ccgcttacct tgtctattat ttcagttctg 1626781 ctgattaagt tggaagaaga gacatttgcc attccgattt cttcaatcat tgagacagca 1626841 gttattgaca gaaaagacat tttgcaaacg catgaccgtg aagtgattga ctttagaggg 1626901 catattgtcc ctgtcgttta tttaaaagaa gagtttaaaa tagaagatac aagaaaagat 1626961 gcggaacagc tccatatcat tgtcgtgaaa aaaggcgaca aacctactgc atttgtggtg 1627021 gactccttta ttggccagca ggaagttgtg ctgaaatcac tcggagatta tttaacaaac 1627081 gtctttgcaa tttccggagc tactatttta ggagacggag aagtagcgct cattattgat 1627141 tgtaatgcac tgattattta accattcgag gaggtgtctc acatgactgc agaaattaaa 1627201 acaggcgaaa aaatgatagt ctttatggta aatggcaaag aatatgccat ttccgtcact 1627261 caggtgaaat caattgaaaa atggcaaaag ccaacgaggg tacctggcgt cgaaccatat 1627321 atttgcgggg taatcaattt acgcggggtg gtgactccgg ttattgattt aagaaaacgc 1627381 ctgaatttgc cagagtatga aattacagat gaaacacgaa ttatcattat tgcttatcgt 1627441 gatattgaag tcggctggat tgtggatgaa gcgaatgatg tgattaccgt acacgaaagt 1627501 gaaatagaat ctgctccaga aggcgttcag aaagatacgg atgtgtcgat cgaacagatt 1627561 gtgaaacaag agaacagact cttaaatatt attgatgcga acgcggtttt ggataaagaa 1627621 tcatctcagt ccgctgtgcc cgatcaagct taatcttaaa ggggttatga catgagtatt 1627681 tttaatggaa tcaaagaaga gcagatggac attttgcggg aagtcggcaa tataggcgcc 1627741 ggccactccg cctctgcaat ggcccagctg ttaaatagaa agatagatat ggaagtccca 1627801 tttgcaaagc tgctgtcttt tgatgagctt gttgattttt tcggcggcgc cgatgtcccg 1627861 gttgccagca tctttttaag aatggaaggc gatttaacgg gttcaatgtt ctttataatg 1627921 cctttttttc aggcggagca gtttatcaga gagctgattg gaaaccccga ttttgacata 1627981 gaggacttag gtgaagacca catgagctca tccgctttgc atgaactggg caatatttta 1628041 gcggggtcat atttaacagc tttggcggat ttgacgaaac tccagctcta tccaagtgtt 1628101 cctgaagtct cattggacat gttcggagct gtgatcagcg aagggctgat ggagctcagt 1628161 caggttggag aacacgccat tgttgtcgac acgtcaattt ttgaccaaag ccatcagcag 1628221 gagctgaaag cgcatatgtt tatgctgccg gactatgatt catttgaaaa gctctttgtc 1628281 gccttaggtg catcattatg agtacaactg aggctgttgt tataaaggtt gggattgctg 1628341 acgtgaagat cgcccgcttc ccggatacca tccggacctc tggtttgggc tcatgtgtgg 1628401 ggctggtgct ttatgataaa gaaaagcaaa cggcgggtct tgttcatgtc atgcttccgg 1628461 attcgacgtt atcgaaaact gccgagctca accgggctaa gtacgctgac accgccgtac 1628521 agaccacgat tgatatgctg atagaagcgg gatgccggaa atttgcatta aaagcaaagc 1628581 tggccggcgg atcagagatg tttaaattta aatcgacaaa tgatttgatg aagatcggac 1628641 cgagaaatgt attagcgata aaagaacagc tgtctttatt taatattcct attattagtg 1628701 aagatacggg cggctcaagc ggccggacga tagaatttga accgaagtcc tgcatgctgc 1628761 atattcgaac tgttaaacaa ggtgaaaaaa cgatttaatt aaggtattag ggggataaca 1628821 atgcaatcct tgaattatga agatcaggtg ctttggacgc gctggaaaga gtggaaagat 1628881 cctaaagccg gtgacgactt aatgcgccgt tacatgccgc ttgtcacata tcatgtaggc 1628941 agaatttctg tcggactgcc gaaatcagtg cataaagacg atcttatgag ccttggtatg 1629001 cttggtttat atgatgccct tgaaaaattt gaccccagcc gggacttaaa atttgatacc 1629061 tacgcctcgt ttagaattcg cggcgcaatc atagacgggc ttcgtaaaga agattggctg 1629121 cccagaacct cgcgcgaaaa aacaaaaaag gttgaagcag caattgaaaa gcttgaacag 1629181 cggtatcttc ggaatgtatc gcccgcggaa attgcagagg aactcggaat gacggtacag 1629241 gatgtcgtgt caacaatgaa tgaaggtttt tttgcaaatc tgctgtcaat tgatgaaaag 1629301 ctccatgatc aagatgacgg ggaaaacatt caagtcatga tcagagatga caaaaatgtt 1629361 ccgcctgaag aaaagattat gaaggatgaa ctgattgcac agcttgcgga aaaaattcac 1629421 gaactctctg aaaaagaaca gctggttgtc agtttgttct acaaagagga gttgacactg 1629481 acagaaatcg gacaagtatt aaatctttct acgtcccgca tatctcagat ccattcaaag 1629541 gcattattta aattaaagaa tctgctggaa aaagtgatac aataatgaat ttcatggtta 1629601 gcgagtgaaa aacatgtcaa cactattatg gcttttaagc tttatgctcc acggcgttct 1629661 tctgtacgct gtcattatcc tgtatacgag gctcgctgca gtgaaagaaa cagaaaaaca 1629721 gcaaaaacag atacttgaag agacggaaaa caccttggcg gcatttctgc ttgaattaaa 1629781 agaagaaaat gagaaactga tagaaaataa agcttcatct gcaagtcaat cagatgaaga 1629841 atcccaaaag tcaggccttc agacctctga aacatatcaa gagcgggatc cagtccaaga 1629901 ggcagagaat cttcctgaac atattgaagg tctgattaca gaggttgacc gtcgggaaga 1629961 gctcgtaaac agtgaggtcc aatcatttga agaccaggtc atagaattat atgaacaggg 1630021 atattcggca agtcaaattg cccagaaaat gaagagcgga aagacagaaa tcgagctatt 1630081 tttaaaattt cgctccaaag gtgtaaagga ttcttgattg tcggataaag ctgtgttata 1630141 ttatgtcttg gtgttaaata cacacgctta acgatttatg cagagggtgc tgcaggcggc 1630201 agttctgtac aaaaatgacc taagcggagg aaaaaaacca ttatattagg aggaaataac 1630261 atgtcagtca tttctatgaa gcaattgctt gaagctggtg ttcacttcgg tcaccaaaca 1630321 cgccgttgga acccaaaaat gaagcgttac attttcacgg agcgtaacgg aatctacatc 1630381 attgaccttc aaaaaacagt caaaaaagta gaggaagctt acaacttcac taaaaatctt 1630441 gctgctgaag gcggaaaaat ccttttcgtc ggaacaaaaa aacaagctca agattctgtt 1630501 aaagaagaag ctcaacgctc tggcatgtac tatgtcaacc aacgctggtt gggcggtaca 1630561 ttaacaaact tcgaaacaat ccaaaaacgt attaaacgtc ttaaagacat tgaaaaaatg 1630621 caagaaaacg gtacgtttga tgtacttcct aaaaaagaag tcgttcaatt gaaaaaagaa 1630681 ttagagcgtc ttgaaaaatt cctaggcgga attaaagata tgaaggatct tcctgatgca 1630741 ttattcatca tcgatcctcg caaagagcgc atcgctgttg cggaagctcg caaattaaac 1630801 atccctatca tcggtatcgt agatactaac tgtgatccag atgaaatcga tgttgttatc 1630861 ccagcgaacg atgacgctat ccgcgctgtt aaacttctaa cttctaaaat ggcagatgca 1630921 atcttagaag cgaagcaagg cgaagaagaa gcggaagttg ctgaagaaac tgcaccagaa 1630981 acagaaacaa caactgcgta acctattcaa aaggtgataa gagggactgc cttttatcac 1631041 cttttttcaa gaaaaatgtg taatatacat actcttgttt aaacatataa ggaggaatac 1631101 aaatggcaat tactgcacag caagtaaaag aactgcgtga aaaaactggc gcgggcatga 1631161 tggattgtaa aaaagcgtta actgaaactg acggagatat ggacaaagca attgaccttt 1631221 taagagaaaa aggaattgca aaagcagcga aaaaagctga ccgtatcgca gcagaaggtt 1631281 ctactcttat taaaactgac ggcaacaaag gcgttatcct agaagtaaac tctgaaactg 1631341 atttcgttgc gaaaaacgaa ggttttaaag agcttcttaa cactttagct gaccaccttc 1631401 ttgcaaacac gccagctgat gttgaagaag caatgggcca aaaaatggaa aatggctcaa 1631461 ctgttgaaga gtacatcaca agcgcagttg ctaaaatcgg tgagaaaatc actcttcgcc 1631521 gctttacagt tcttacaaaa gacgacagct ctgcattcgg tgcgtacctt cacatgggcg 1631581 gccgcatcgg tgtattaact gttctcaacg gtacaactga tgaagaaact gcgaaagata 1631641 tcgcaatgca cgttgctgca gttaaccctc gttacatttc tcgtgatcaa gtatctgaag 1631701 aagaaacaaa tcatgagcgt caaatcttaa ctcagcaagc cctccaagaa ggcaaacctg 1631761 aaaacatcgt agcgaaaatg gttgaaggcc gtctgaacaa attcttcgaa gaaatttgtc 1631821 tattagacca agcgttcgtt aaaaacccag atgaaaaagt gaaacaagtt attgcagcga 1631881 aaaacgctac tgttcaaact tttgtccgct atgaagttgg agaaggcatc gaaaaacgtc 1631941 aagaaaactt tgctgaagaa gtaatgaacc aagtgaaaaa ataatggtga aaagatttcg 1632001 cggctaagtc gcgtcttttc aggcagtata ggggacacat tttgtgttcc ctatttttaa 1632061 aactatattt acaaaccttt ttttctcttg cataatagaa aacggcaatg tttacacttg 1632121 gaggttatca tggaaaaacc aaaatacaaa cgtatcgtat taaagcttag cggggaagca 1632181 ttggcaggag aacagggaaa tggaattaac ccgactgtca ttcaatccat tgcaaagcaa 1632241 gtgaaggaaa tcgctgagct tgaagtcgaa gtggctgttg ttgtaggcgg cggcaactta 1632301 tggcgcggaa aaacaggaag tgacctgggc atggaccgcg cgactgctga ctatatggga 1632361 atgctggcga cagtaatgaa ttcgcttgct cttcaagaca gcttggaaac actcggaatc 1632421 cagtccagag tgcaaacatc cattgaaatg agacaagttg ctgaaccgta cataagaaga 1632481 aaagcgatac gccacttaga gaaaaaacgt gtcgttattt tcgctgcggg cacaggaaac 1632541 ccatatttct caactgatac gacagctgca ctgcgggctg ctgaaattga ggcagacgtt 1632601 attttaatgg ctaaaaataa cgttgacggt gtgtataatg ctgatcctag aaaagatgaa 1632661 tcagctgtta agtatgaatc actttcttat cttgacgttc ttaaagacgg cctggaagtc 1632721 atggattcaa cagcttcctc tttatgcatg gacaatgaca ttccgcttat cgtcttttct 1632781 attatggaag aaggaaatat caaacgtgcc gttatcggtg aatcaatcgg aacgatcgtg 1632841 agggggaaat aacgtgtcaa aagaagtatt aactcaaaca aaagaaaaaa tggaaaaagc 1632901 aattgctgct tatcagcgcg aattggctac tgtacgcgca ggccgtgcaa atccatcatt 1632961 attagataaa gtaacggttg aatattacgg agcgcagaca cctttaaatc agttgtcttc 1633021 tattaacgtg cctgaagctc gtatgctcgt tatcacgcca tacgataaaa cagcaatcgg 1633081 tgatatcgaa aaagcgattt taaaagctga tttaggtctt acaccaacaa gtgacggcaa 1633141 tatgattcga attgcaattc cggcactaac agaagagaga cggaaagaat tagtgaaagt 1633201 tgtaaaaaaa tatgctgaag aagcaaaagt agctgttcgt aacgttcgcc gtgatgctaa 1633261 cgatgatctc aaaaaacttg agaaaaacgg agacattact gaggatgaac tgcgtgcttc 1633321 cactgaagac gttcaaaaac tgacagatga atatgtgtca aaaattgaca gtgtcacaaa 1633381 agacaaagaa aaagaaatca tggaagttta atgaaaaact atgtacaata gataatagtg 1633441 aaaagaccct ctcatgttta cagggggttt ttttgttaat actgttgatt acattgatta 1633501 tcagcaggga atgtaacctt tttgggtgac ggaggaatct catgctcaac atactcaaaa 1633561 attggaagaa tcagcaaact gcggcttcca acttagaacg ttatacaaaa gaagacatac 1633621 ttaagggaga aattcccgaa cacatcgcca ttatcatgga tggaaatggc cgttgggcta 1633681 aaaaacgctc tcttcccaga attgcaggcc accatgaagg gatgaaggtg gtaaaaagga 1633741 ccacgaagct cgcaaacgaa ttaggtgtca aagtactgac attgtatgca ttttcaacag 1633801 aaaactggaa aagaccgaaa atggaggtcg attttttaat gaagcttccg gaagaatttt 1633861 tgaatacgta tcttccagag cttgttgagg aaaatgtaca ggttcggatc attggggatg 1633921 aaacggcttt gccggcgcac acattacgtg cgattgaaaa agctgtacag gacacggcgc 1633981 aaaacgacgg aatgatcctt aattttgctc ttaactatgg aggccgtact gaaattgtca 1634041 gtgctgcaaa atcactcgcg gaaaaagtga aggaaggctc tttgaatatt gaagacattg 1634101 atgaatcgct tttttctact tatttgatga ctgaatcttt gcaggatcct gaacttttaa 1634161 ttcgaacgag cggcgagata aggctgagta attttatgct atggcaggtt gcctacagtg 1634221 aatttgtctt tactgacgtc ttgtggcctg actttaaaga agatcacttc ttgcaggcgt 1634281 taggagagtt tcagcagaga ggccggaggt ttggcggaat ttagaggatg gtggacatga 1634341 aacaaagaat tttgacaggt gttctggcag caattgtatt tttatttttg gttattgtcg 1634401 ggaaattgcc gttcaccata ttaatttatg ctatgggcag tgtggcgctt tttgaacttt 1634461 tacggatgaa aaagctgaag ctggtttcac tgccgggttt gatcggtctt ttattattgt 1634521 ggatgttctt attaccaagc cagtattcgt tttttgaagc ggacgggatt tccaaaatgg 1634581 aaatcgcttt atttgcggta ctgctattgc tgacttacac agtgttggtc aagaacacct 1634641 ttacttttga tgaagtcggg tttattacgc ttgcagcaat ttacatcgga atgtgttttc 1634701 attattttat cgaaatcaga aatcttgacc aatacggatt aacatacatt ttttatgcgt 1634761 gtgttgtcat ttggtccacc gattccggtg cctattttgt cggtaaatcg cttgggaagc 1634821 ggaaactgtg gcctgaaatc agtccgaata aaacagtgga agggtttgca ggcggaattg 1634881 tcatcgcact tgtattggcg acgatttttc agcttgttgc acaacttccg atcccgtata 1634941 tctatctgct gttgatcacg ctgtttttgt ctgtttttgg acaactggga gatttagtgg 1635001 aatccgcctt gaaaagacat tacgatgtaa aggattctgg gaatattctt cccgggcatg 1635061 gcggtatatt agaccgtttt gacagtttct tgtttgtcat gcctttcttg tactttctgc 1635121 ttgccctttt ttcataaaaa agtctaatat gaatatgaga ctgatcatgc agcaataaga 1635181 ataggagtag tggcaacttt gaaaaatatt tgtcttttag gagcaacagg atcaatcggc 1635241 gaacagactc ttgatgtact gcgtgcacat caagaccaat ttcagctggt atctatgtcg 1635301 tttggcagaa atattgataa ggccgttcca atgattgagg tctttcagcc gaagtttgtc 1635361 tctgtcggtg atctggatac atatcataaa ttaaaacaaa tgtctttttc ttttgaatgc 1635421 caaatcgggc tgggagaaga aggactgata gaagcagcag tgatggagga ggttgacatt 1635481 gttgtcaacg ctttgcttgg aagcgtcggt cttatcccga cattaaaggc aattgaacag 1635541 aaaaaaacaa ttgcgcttgc aaataaggaa actcttgtca ctgcagggca tatagtaaaa 1635601 gaacatgcta agaaatatga tgttccgctg ctgcctgttg acagtgagca ttcagccatt 1635661 tttcaagctc ttcaaggcga acaggctaaa aacattgaac gcctcatcat tacggcatcc 1635721 ggcggaagtt ttcgggacaa gacgcgggag gagctcgaat cagtaacggt tgaagatgca 1635781 ttaaaacatc caaactggtc aatgggtgca aaaattacaa ttgattcggc tacaatgatg 1635841 aataagggat tagaggtgat cgaggcacac tggcttttcg atatacctta tgaacaaatt 1635901 gatgtggttt tacataagga gagcatcatc cattcaatgg ttgagttcca tgataaaagt 1635961 gtgatcgcac agctcggaac tccggatatg agagtcccca ttcaatatgc gctcacttat 1636021 cctgaccgat tgccattacc agatgcgaaa aggcttgaat tatgggaaat cggcagcctt 1636081 cattttgaga aagctgattt tgacaggttc cgatgcttac aatttgcttt tgaatcaggt 1636141 aaaataggag gaacaatgcc gacagtgcta aatgcggcaa acgaagtagc tgtcgctgcc 1636201 tttttagctg gcaagatacc gtttttggct attgaagact gtatcgaaaa ggcactaacc 1636261 cgccatcaat tactgaaaaa accgagcctg gcggacattc aagaagtgga caaagatacc 1636321 cggggatacg tcaattcaat actcacataa ggtggtatgt tcgtgaatac agttatagcg 1636381 tttatcatta ttttcggaac gctcgttttc ttccatgaac tgggccattt attgctagcc 1636441 caaagagcgg gaattctctg ccgtgaattt gcgatcggct tcggtccaaa gattttttct 1636501 ttcaaaaaaa atgaaacagt ttatacgatc aggctgcttc cggtcggcgg atttgttcgt 1636561 atggccggcg aagatccgga aatgattgag gtgaaacccg gatacacggt cgggcttctg 1636621 tttaataagg aagatcaagt tgagaaagtc atcatcaatc aaaaggaaaa atatccggat 1636681 gctttagtca ttgaagtgga aacagcggat ctagagcatg acatgaagat caccggttat 1636741 gaacagggga aagaggacga actttccagc tttactgtca gcgaaacatc cttttttatt 1636801 gtagacggag aagaagtgca gattgcgccg tataatcgcc aatttggttc caaacctgta 1636861 tggcagcgga ttaaagcaat tgctgcaggg ccgattatga actttatttt agcttacgtc 1636921 attttagtga tgcttgggct gattcaaggc gtaccgtcaa atgaacctat gctcgggcag 1636981 ctgacagaca atggacgggc ggctgaagca gggctaaaag aaggggatta tatccaaagc 1637041 attaacggag agaaaatgag gtcttggact gacattgtct ccgctgtaaa agaaaacccg 1637101 gagaaagaaa tggacgttgc agtaaaaaga gataacaaaa cgcttcatat ttcggtgact 1637161 ccggaagctg ttaaagatga gaacaaaaaa acaatcggac gtttcggttc ctatgcgccg 1637221 actgaaaaag gcgtactctc agcggttgct tacggcgcga catcaacagt tgatgtcacc 1637281 aaagccattt taaccaatct gagcaaatta gtaacaggcc aatttaaact cgatatgctg 1637341 tcaggtcctg tcggcatata tgacatgaca gaccaagtgg cgaaaacagg gatcgtgaac 1637401 ttatttcagt ttgcggcgtt tttaagcatt aaccttggga ttgtcaacct gcttccgatt 1637461 ccggcacttg acggaggaag actgttgttt ctatttattg aagcgattcg gggcaaaccg 1637521 attaacaggg aaaaagaagc atttgttgtg tttatcggag tagctttctt aatgcttctt 1637581 atgctggttg tcacatggaa cgatatccag cggctgtttt tgtaaacgaa aagtaaatca 1637641 atcagaggtg cgaagaaatg agacaaagct tgacgcttat tcctacgctc cgtgaagttc 1637701 cagctgatgc cgaagcaaaa agtcatcagc ttcttctgag agcaggattt atcagacaga 1637761 atacgagcgg ggtatacagc tatatgcctc ttgcgtataa ggtgattcaa aacattcagc 1637821 agattgttcg agaggaaatg gagaaaattg atgccgtaga aatgctcatg cccgcattgc 1637881 agcaggcaga gacatggcag gaatcaggca gatggtatac gtatggtccc gaactgatga 1637941 gactaaaaga ccgtcatggc cgtgaatttg ctttaggggc aacgcatgaa gaggttatca 1638001 cttcgcttgt tcgcgatgag gttaaatctt ataagcgtct ccctctgact ctttatcaaa 1638061 ttcagtctaa gttcagagat gaaaaacgtc ctcgcttcgg tttgttaaga ggccgcgaat 1638121 ttattatgaa ggatgcgtac tctttccatg catctgcaga gagcctggat gaaacgtatc 1638181 aaaaaatgta cgaggcctat tctaatattt ttgcccgctg cggcattaat gtaagacctg 1638241 ttatcgctga ttcaggcgca atgggaggaa aggatacgca cgaatttatg gcactttctg 1638301 cgatcggaga ggatacgatt gcgtattctg atgaatcaca gtacgcggct aatatcgaga 1638361 tggctgaagt tcttcaccag gaagttcctt cagatgaaga gcctaaagct ctagagaagg 1638421 ttcatacgcc taacgtgaaa acaatcgaag aactgactgc gttcttacag gtttcggctg 1638481 aagcgtgcat taagtcagta ttgtttaaag ctgatgaccg ttttgtctta gtgcttgtaa 1638541 gaggggatca tgaagttaac gatattaaag tgaaaaactt gcttcatgca gaagttgtag 1638601 agcttgctac acatgaagag gtcattcagc agctcggaac agagccaggc tttgtaggcc 1638661 ctgtcggtat tcatcaggat gtggaagtat atgccgatca agctgtgaaa gcaatggtta 1638721 atgctgttgc cggggcaaat gaaggagatc atcattataa aaatgtcaat gtgaatcgtg 1638781 acgcgcaaat taaagaattt gctgatcttc gttttattaa agaaggtgat ccttcaccag 1638841 acggcaaggg aacgatccgt tttgctgagg gaatcgaagt cggacaagtc tttaagctcg 1638901 gaacacgcta ttcagaagcg atgaatgcga catatttaga tgaaaacgga cgcgcgcagc 1638961 caatgctgat gggctgttac ggaatcggtg tgtcaagaac gctttctgct attgctgaac 1639021 agcatcacga cgaaaaaggc ttaatatggc caaaaagcgt tgcgccgtac gatcttcata 1639081 ttcttgcttt gaacatgaaa aacgatgggc aaagagagct tgctgaaaag ctgtatgccg 1639141 atttaaaagc ggaaggctat gaagtgctct atgatgaccg tgctgagcgt gccggcgtaa 1639201 aattcgctga ttcagattta atcggccttc caatccgcat cactgtcgga aaacgagctg 1639261 acgaaggaat cgtcgaagtg aaaattcgtc aaactggtga gtcaactgag atttcagtag 1639321 acgaattatc tgcgtttatc agcaagcagt aatcaccata acgatttatc aaaaaacatg 1639381 ttaaaataga aataatagaa ggtacctcat tgcctgaggt accttcactt atgatgtttt 1639441 tagggaggga tactgtctta atggaacagt tatcagtaaa cagaaggcag tttcaaattc 1639501 ttctgcagca gattaatatg acagatgata ccttcatgac atactttgaa catggcgaga 1639561 ttaaaaagct gacaattcac aaagcttcta agtcttggca ttttcatttt caatttaaat 1639621 ctttgctgcc ttttcaaata tatgacacat taacaacgag gctgacgcaa tcgtttgccc 1639681 acatagcaaa agtgacatct tcaattgaag ttcaggatgc cgaggtcagt gaaagtatcg 1639741 ttcaagacta ctggtcacgc tgcattgaag aactgcaggg catttcgccg ccgattatca 1639801 gtcttttaaa ccagcaaaaa ccgaagctga agggcaataa actgattgtc aaaaccaaaa 1639861 cagatacaga agcggctgcg ctaaagaaca aatacagttc catgattcaa gcagaatacc 1639921 gtcaatttgg ctttccggat cttcagcttg atgctgaaat atttgtatcc gagcaagaag 1639981 ttcaaaagtt tcgggagcaa aagcttgcgg aagaccaaga gcgggctatg caggccttga 1640041 ttgaaatgga gaagaaagat aaagaaagtg atgaagacca agcaccatct ggtcctcttg 1640101 ttatcggtta tcaaattaaa gataacgagg aaatccgaac acttgacagc atcatggacg 1640161 aagaacggag aattacggtc caaggttatg tgtttgatgt ggagacgcgc gagctgaaga 1640221 gcgggcgcac gctgtgtatc ttcaaaatta cagactatac aaatagtatt ttgatcaaaa 1640281 tgtttgcacg tgaaaaagaa gatgcggcgc tgatgaagtc tctgaaaaaa ggaatgtggg 1640341 taaaagcacg cggaagcatt caaaatgata catttgtcag agaccttgtc atgatcgcaa 1640401 atgacgtaaa cgaaataaaa gcaaaaaccc gtgaagattc agcacctgaa ggagaaaaaa 1640461 gagtggaatt gcatcttcat tccccaatga gccaaatgga tgctgttacg ggtatcggaa 1640521 agcttgtcga acaggcgaaa aaatgggggc atgaggccat cgctttgacc gaccatgctg 1640581 tcgttcaatc cttccctgat gcgtattctg cggccaaaaa gcatggaatt aaaatgattt 1640641 acgggatgga agcgaatctc gtggatgatg gcgtgccaat tgcttataat gccgcacatc 1640701 gtctgctcga agaagaaaca tatgttgttt ttgacgttga gacgacagga ttgtctgctg 1640761 tatacgatac cattattgag ctggctgcag taaaagtaaa aggcggagaa attattgata 1640821 aatttgaggc gtttgcgaac ccgcatcgtc cgctttccgc cacaatcata gagctgacag 1640881 ggatcacaga tgatatgcta caagacgctc cggatgtcgt agatgtaata agagatttca 1640941 gagaatggat tggcgatgat attcttgtcg ctcataatgc aagctttgat atgggattct 1641001 taaatgtagc ctataaaaaa cttcttgaag tcgaaaaagc taaaaaccca gtcattgata 1641061 cgcttgaact tggacgtttt ctctatccgg aatttaagaa ccaccggttg aacacacttt 1641121 gtaaaaagtt tgatatcgag ctcacacagc atcaccgtgc gatctatgat actgaggcaa 1641181 ccgcttattt gcttctgaaa atgctgaaag acgcagctga aaaaggtatt cagtaccatg 1641241 atgagttgaa tgaaaatatg ggtcagtcca atgcttatca aagatcaaga ccgtatcatg 1641301 caacattact tgccgtgaac agcacgggac ttaaaaattt atttaagctt gtgtcacttt 1641361 ctcatattca ttatttttac agagtgccgc gtattccgag atctcagctt gagaaataca 1641421 gggaagggct tctgatcggt tctgcttgtg acaggggaga ggtttttgag ggaatgatgc 1641481 aaaaatcgcc tgaagaggtg gaagatatcg cgtcattcta tgattacctt gaggttcagc 1641541 cgcctgaagt gtatcgtcac ttgctggagc ttgaactggt ccgtgatgaa aaagcgctga 1641601 aagaaattat tgcgaatatc acgaagctgg gggaaaagct taataaaccg gttgttgcta 1641661 cgggaaatgt tcattacttg aatgatgagg ataaaatcta cagaaagatt ttaatatcct 1641721 cacaaggcgg ggcaaatccg ctgaataggc atgaactgcc gaaagtgcat ttcagaacga 1641781 cagacgaaat gcttgaagct ttttctttct taggtgaaga aaaagcgaag gagatcgtag 1641841 tcaccaatac ccaaaaggtt gcttctttag ttgatgacat caagccgatt aaagatgatt 1641901 tatatacgcc gaaaatcgaa ggcgctgatg aagagatcag agaaatgagc tatcagcgtg 1641961 caagaagcat ttacggggaa gagctgcctg aaattgtcga agcgcggatt gaaaaagagt 1642021 taaagagtat tattggccac ggatttgctg ttatttactt gatctctcac aaacttgtaa 1642081 aacgttcact agatgacggg tatctcgttg gttcccgtgg ttccgtagga tcttcattag 1642141 ttgcgacact tactgagatt actgaggtaa acccgctgcc gccgcactat gtttgtcctg 1642201 agtgccagca ttctgagttc tttaatgacg gttctgtcgg ttctggtttt gacctgcctg 1642261 acaagacatg ccctcattgc ggaacgcctt tgaaaaaaga cggccatgat attccatttg 1642321 aaacgttctt aggatttaaa ggggacaaag tacctgatat cgatttgaac ttctcagggg 1642381 aatatcagcc gcaagcacac aattacacaa aagtattgtt cggagaagac aatgtatatc 1642441 gtgcgggaac aataggcacg gtggcagaaa aaacagccta cggttatgta aaaggctatg 1642501 ccggagacaa caatcttcat atgcgcggtg ccgaaataga tcggctcgta cagggatgca 1642561 caggtgtaaa acgtacaact ggacagcacc ctggcggtat tatcgtagtt ccggattata 1642621 tggatattta tgatttttca ccgatccagt tcccggcaga tgccacaggt tcagagtgga 1642681 aaacgactca ttttgatttc cactccatcc atgacaacct gttaaaactt gatattctcg 1642741 gacacgatga cccgactgtt attcggatgc ttcaagactt aagcggaata gatccgaaaa 1642801 caattccgac ggatgatcct gaagtgatga agatcttcca gggaaccgaa tcactcggtg 1642861 tgactgaaga acagattggc tgtaaaacgg gcactcttgg aattcctgaa ttcggaaccc 1642921 gatttgtccg gcagatgctt gaagatacaa agccgaccac tttttctgag ctcgttcaga 1642981 tttcaggctt gtctcacgga actgatgtat ggcttggcaa tgcacaggag ctcatccaca 1643041 ataatatttg tgagctgagt gaggttatcg gctgccgtga tgacattatg gtttatttaa 1643101 tctatcaagg ccttgagccg tcccttgcct ttaaaatcat ggaattcgtg cgtaaaggaa 1643161 aaggattaac gcctgaatgg gaagaagaaa tgaaaaataa caatgtccca gactggtata 1643221 ttgattcctg taaaaagatt aaatacatgt tcccgaaagc ccacgccgcg gcatatgtct 1643281 taatggcagt ccgcattgct tactttaaag tgcatcatgc tcttttgtat tatgcggctt 1643341 attttaccgt tcgtgcagat gactttgata ttgatacaat gatcaagggc tctacagcaa 1643401 tcagagcggt aatggaggat ataaacgcta aaggacttga tgcttcaccg aaggaaaaga 1643461 accttctgac tgttttagaa ttagcgcttg agatgtgtga gagaggctat tcattccaaa 1643521 aagtcgattt atatcgctcc agcgccacag agtttattat tgacggcaac agtcttattc 1643581 cgccgtttaa ctctattcca gggttaggga cgaacgctgc tttgaacatt gtaaaagctc 1643641 gcgaagaagg cgaattcctc tcaaaagaag atttgcaaaa gagagggaaa gtatcaaaaa 1643701 cgattttaga gtacttagat cgccatggct gtctggagtc actgcctgat caaaaccaat 1643761 tgtcactgtt ctaatatgga aagcagaatt tctcagaaat tctgcttcta tgcatacata 1643821 agcgcaaaaa gtgccatcgt aatattagag tttctgtcac ttgcttaggt atgaaggtaa 1643881 gcgtatatcc atttgcaata aaaatatggt tatggtatag ttttattgga aatgctaacg 1643941 attaccgagg caaagagtgg ggaaacccgc tcttttgtat tgaacaggag aattttgtct 1644001 cgacatgttc atcgtttact ttttagcccc tgctcttttg aagcagggtt tttatgcaga 1644061 gtgacgagac gaatatgaga tcgacagcac aaggaggaag aacatgagca aaaaagtgac 1644121 tgacaccgtt caagaaatgg ctcagccaat cgtagacagc cttcagctgg aactcgttga 1644181 cattgaattt gtcaaagagg gccaaagctg gttccttcgc gtgtttattg attccgatga 1644241 cggtgtggat attgaggaat gtgccaaagt aagcgaagct ttaagcgaaa agcttgatga 1644301 ggcagaccca atcagccaaa attactttct tgaagtctca tctccaggag ctgagcgtcc 1644361 gctaaagaaa aaagccgatt tcgaaaaatc actaggaaaa aacgtataca ttaagacgta 1644421 tgagcctatt gacggcgtaa aagtgtttga aggtgaactg gctgaatttg atggacaaac 1644481 agtgacagtt gagatcacga tcaaaacaag aaagaaacgg atcaatattc cgtatgaaaa 1644541 gatagctaat gcaagattag ctgttacatt ctaatgaata caaatgtttt aaggggggag 1644601 accgttaaat gagcagtgaa ttattagatg ctctcacgat tcttgaaaaa gaaaaaggca 1644661 tcagtaaaga aattatcatc gaagcaatcg aagctgcgtt aatttctgct tataagcgga 1644721 attttaatca agcgcaaaat gtacgggtgg atctaaaccg tgaaactggc tccatccgtg 1644781 tatttgcaag aaaagatgtc gttgacgaag tatacgacca gagattagaa atctcaattg 1644841 aagaggcaca gggcatccat ccggaatata tggtcggcga tgtcgtcgaa atcgaagtta 1644901 cacctaagga tttcgggcgc atagctgctc aaacagcgaa gcaggtcgtc acacagcgtg 1644961 tgcgcgaagc tgagcgcggt gtgatttatt ctgaatttat cgaccgtgaa gaagacatca 1645021 tgacagggat cgtccagcgt ctggacaata aatttatcta cgtgtcttta ggcaaaatag 1645081 aagccttgct gccggttaat gagcaaatgc cgaatgaaag ctacaagccc catgaccgca 1645141 ttaaggtata tatcacaaaa gtagaaaaaa caacgaaggg tccgcagatt tatgtgtcaa 1645201 gaacacatcc aggcctgtta aagcgtttgt ttgaaattga agtgcctgaa atttatgatg 1645261 gaactgtcga gctaaaatct gttgccagag aagccggcga ccgttcgaaa atttctgttc 1645321 gcacagatga tcctgacgtt gatcctgtcg gttcatgcgt agggcctaaa ggccagcgtg 1645381 tgcaagcaat cgtcaatgaa ttaaaaggtg aaaaaattga cattgtcaac tggtccagtg 1645441 atcctgtaga atttgtcgcg aatgcgctca gcccttccaa agtgcttgat gtcattgtta 1645501 atgaagaaga aaaagcgaca actgttattg ttcctgatta ccagctgtct ctggcaattg 1645561 gaaaaagagg acaaaacgca cgcttagctg ctaaactgac aggctggaag attgatatta 1645621 agagcgaaac ggacgcaaga gaacttggaa tctatccgag agaacttgaa gaagatgatg 1645681 agccgctctt tacggagcct gaaactgctg aatcggatga ataagaggtg actttaggtg 1645741 aataaacaca aaaagatccc attacgcaaa tgtgtagtga ctggtgaaat gaagcctaaa 1645801 aaggaactga tccgagttgt acggtcgaaa gaaggcgaaa tctcagtaga cccgaccgga 1645861 aaaaagaatg ggcggggtgc ttatttaacg ctggataaag agtgcatctt agcagcaaaa 1645921 aagaaaaaca ctttgcaaaa tcaatttcaa tcacaaatcg atgaccagat tttcgatgaa 1645981 ttgctggaac tggcggaaaa ggtgaaaaaa taaaatgtct ggaatggaat ggtttccctt 1646041 gctgggtctg gccaatcgag ctcgtaaggt cgtgtcaggc gaagacttgg taataaaaga 1646101 aatcaggaat gcgcgtgcaa agcttgtcct gcttacagag gatgcatcat ctaacacagc 1646161 aaaaaaagta actgacaagt gcaattatta taaagtccct tataaaaaag tcgagagtcg 1646221 cgcggttctt ggacgctcta tcggtaaaga agcccgtgtc gttgtcgccg tcactgacca 1646281 aggttttgcg aataagctga tcagcttgct cgattaatat ttttgggggt gaacgaatgg 1646341 ctaaaatgag agtatacgaa tatgcaaaag cgttaaatgt ttcaagtaag gaaattttga 1646401 ccgcactgaa gaacatggat ttagaagtga ataatcacat ggccatgctt gaagaaaagg 1646461 ccattaaaaa gctagatgcc aaatataaaa aaggcggcgc agctgctaaa tctcaaaagc 1646521 cagcagaaac gaacaaaaac aaacagccac aaggggttaa tcagcaatca gctggaaatc 1646581 aaccaaataa aattcgagac ggaaagaaga atgacgtgca gaataatcaa tttaacaaaa 1646641 acaagaagaa taacaacaac aaaaaaaata aacgcaacaa caacaataat aaaaaccaac 1646701 atcagcaaaa gcctgtaaag ccgaaaaaag agcttcctga gaaaattaca ttctctggca 1646761 ctttaacagt tggcgcactt gctgaagagc ttggcaaaga gccttcagaa ctcattaaaa 1646821 agctgatgct tcttggcgta atggcaacca ttaaccaaga gcttgataaa gacacaatcg 1646881 aactcattgc atcagaatat ggtgttgaaa cagaagaggt cattgtgctt gaagaaacag 1646941 agctggaaaa atacgaagag cctgataatg aagaggatct tgaaattcgt cctcctgtcg 1647001 tgacaatcat gggccacgtt gaccatggga aaacaacgct tcttgacagc atccgtaaaa 1647061 caaaggttgt tgaaggggaa gcaggcggaa tcactcagca tatcggcgct tatcaaattg 1647121 aagagaacgg caagaaaatc acgttcttgg atacaccggg ccacgccgca tttacaacaa 1647181 tgcgcgcacg cggtgcagaa gtaactgata ttacgattct tgtcgtagct gccgatgacg 1647241 gtgtcatgcc gcaaacagtt gaagcgatta accatgcaaa agcagcagag gttccaatca 1647301 tcgttgctgt gaataaaata gataaagaat ccgcaaaccc tgaccgtgta atgcaagaac 1647361 tgacggaata cggacttgtc cctgaagctt ggggcggaga aaccattttt gtgccgcttt 1647421 ccgctttaac tggaaaaggc attgatgagc tcgttgaaat gattttgctt gtcagtgagg 1647481 tagaggaact gaaagcgaat ccgaatcgtc aggcaaaagg aacggttatt gaagctgaac 1647541 tcgataaagg cagagggtca gtcgcgacgt tgctcgtaca gactggaaca ctgcatgtcg 1647601 gtgatccgat cgtagtcggc aatacatttg gccgtgtccg tgcaatggtc aacgacattg 1647661 gccgccgtgt gaaaactgcc ggcccgtcaa ctccggttga aattaccggt ttgaatgatg 1647721 tccctcaagc gggagaccaa ttccttgtct ttaaggatga aaaaacagct cgttctgtcg 1647781 gtgaagcccg tgcttcgaaa cagcttgaag agcagcgcag cgataaagcg aagctcagtc 1647841 ttgatgattt atttgagcaa attaagcaag gtgatgtaaa agacatcaac ctcatcgtaa 1647901 aagctgacgt tcaaggatct gctgaagctt taacggctgc acttcaaaaa attgaagtag 1647961 aaggcgttaa agtgaaaatc atccatacag gcgttggtgc gattactgaa tcagacatta 1648021 tcttggcatc tgcttccaat gcaattgtta tcgggtttaa tgtgagaccg gacggaaatg 1648081 ctaagagtac ggctgaagct gaaaatgtag atattcgact tcaccgtatc atttacaaag 1648141 taatcgacga gattgaagct gccatgaaag gtatgcttga tcctgaatat gaagaaaaag 1648201 taattggtca agtagaagta cgccaaacat tcaaagtatc taaaatcggt acaattgccg 1648261 gcggatatgt tactgaagga accattacgc gcgacagcgg cctccgttta attcgtgacg 1648321 gcgtcgtcat ctttgaaggc gaagtagatg ttctgaaacg ctttaaagac gatgtgaaag 1648381 aagtttcaca aggctatgaa tgtggtatta caattaagaa atacaatgac attcgtgaag 1648441 gtgacatcct tgaagcgttt gtcatgcaag aaattgaaag aacgtgatcg gatttgcgga 1648501 gtgtgaatgc atcatttatg atgcaggatc gctaaaagaa aagcgtgccg ttctgaagcg 1648561 gattttaacc agggttcaaa acaagttcaa tgtttcgatt tcggagattg gctatcagga 1648621 cacctggcaa agaaccagct tcggaatcgc cgctgtttct tcctctcgcg ttcaaacaga 1648681 aaaagaactg cagcgcgtcc tagcgtttat cgattctttt cctgaaattg aacggacgat 1648741 cactaggaca gagtggtttt aacttagagg tgattgaatt gagtatgaga gcaaaccgtg 1648801 tcggcgagca aatgaaaaaa gaactcggtg atattatcag ccgcaagctg aaagacccga 1648861 gaattggttt tctgacagta acggatgtac gtgtatcagg tgatttgcaa attgcaaagg 1648921 tgtatatctc ggttctcggt gacgagaaaa aacgggaaga agcgctgaaa gggctggcaa 1648981 aagcgaaagg atttatccga tccgaaatcg gcagccgcat cagacttcga aaaacgcctg 1649041 aaattgaatt tgagttcgat gaatcaatcg attacgggaa tcggatcgaa acactgattc 1649101 acgaattaca ttcagagaaa ccatctgaat aaaaaaagag aggataggcg tatatcgtct 1649161 gtcctctttc ttcgtttata agaaaaaaac tcaaaagaag gagtgaaagg caaatggtta 1649221 acggagttct ccttttacat aaacctgttg gcatgacatc gcacgactgt gtcatgaaga 1649281 tccgaaagct gttaaaaaca aaaaaagtag gacatacagg aacgctcgat ccggaagtat 1649341 caggcgtgct tccgatttgt gtaggaagag cgacaaaaat agtcgaatac ttaactgaaa 1649401 aatctaaaac gtatgatgca gaaataacat tgggcttttc aaccacaaca gaggatcaaa 1649461 ccggagaaac ggtggaaaca aagcctgtca atcacgacat tgataaagcg gatgtagaaa 1649521 aggttttaaa cagtttaaag gggaaacaag aacaaattcc gcccatgtat tccgctgtaa 1649581 aagtaaacgg caaaaaatta tacgaatacg caagagcagg gattgaagta gaacgtccga 1649641 aacgtatgat aaccattgaa gacattgccc tgacaacaga gattaaacat catggagaaa 1649701 ccgcaagctt ccggtttaca gtgacttgct ccaaagggac ctatgtaagg acgctggcgg 1649761 tcatgatcgg agaaaagctc ggatatccgg cccatatgtc tcatttaatc cgtacggcat 1649821 ccggagattt ttctctcgac gaatgcttta cttttgatga actcgaagca caggcccaat 1649881 ccggaaccgt ggaagagcat acagttccta ttgaacgtgc gctcaatcat ttgccgaaat 1649941 ggatcataag tgatacatta gctaagaaag tagaaaatgg ggctttgctt gagacgcccg 1650001 agcagttttc tgaaatgaca agtggagacc gtattgccgt ctttactgaa tccggaacct 1650061 gcttggcgat ctatttccct catcctgcaa aaaaagggct gttaaagccg gcaaaagtat 1650121 tgatgcaaaa aagcgaacaa tagaaaaaag gtgaccgttc tgtgaagacg atacatatta 1650181 cacatcctca tcatttaata aaagaggagc aggcaaaatc agtgatggcg ttaggttatt 1650241 ttgacggcgt tcatctcggg catcaaaagg taatcggcac agcgaagcaa atagccgaag 1650301 aaaaaggtct gacattagct gtgatgacct ttcatcccca tccttctcac gtgttgggca 1650361 gagataagga accaaaggat ctgattacgc ctcttgaaga caaaataaac caaattgaac 1650421 aattaggcac agaagttctg tatgtcgtta aatttaatga agtgtttgct tctctttctc 1650481 ctaagcagtt tatagaccag tatattatcg gccttaatgt gcagcacgca gtggcaggct 1650541 ttgactttac gtacggcaaa tacggcaagg gaacaatgaa gaccatgccg gatgatttag 1650601 acggaaaagc tgggtgcaca atggtagaaa aattaacgga gcaggataaa aaaatcagtt 1650661 cttcgtatat ccgtaccgcg cttcaaaacg gagatgttga attggcgaat gtcttgcttg 1650721 gacaacctta ttttattaaa ggaattgtca ttcatggtga taaaagaggg cggaccatcg 1650781 ggtttccgac agcgaatgtc ggtttaaata acagctatat cgttccgccc acaggtgtat 1650841 atgccgtaaa agcggaagtg aacggcgaag tttacaatgg cgtttgcaat attggctata 1650901 agccaacgtt ttatgaaaag cgccctgaac agccttccat cgaggtcaat ctgtttgatt 1650961 tcaatcaaga ggtatatgga gccgctataa aaatcgaatg gtacaaacgg attcggagcg 1651021 agcggaaatt caatggcatc aaagaattaa ctgagcaaat tgagaaagat aagcaggaag 1651081 ccatccgtta tttcagcaat ttgcggaaat aacttgcaac gcacgcaaat tttattctaa 1651141 aatatttgca tataggcacg atttttagta tgatagtttt cgtagtctta aaaccattgc 1651201 ttggcaatcc gaagtcaccg acggttgcta ggtaactggg gctaaatatg atttggaggt 1651261 gaaacaggat ggcaattact caagagcgta aaaaccaact catcaatgag ttcaaaacac 1651321 acgaatctga tactggatct ccagaagttc agatcgctat cctaactgac tcaattaaca 1651381 acttgaacga gcatttacgt actcacaaga aagaccacca ctcacgtcgc ggtcttctta 1651441 aaatggtagg taagcgtcgt aatcttctta cgtatctgcg taataaagac gtaactcgtt 1651501 accgtgagtt aattaacaaa ctaggcttac gtcgataatc gtaaaaagcg ggaggattcc 1651561 cgctttttta tcgtattaaa gcgaaatttc ttataacaaa tcattgaaat ccttttacat 1651621 actactttga cattgatatg ttcaattcat ttcgttcata ataggagtaa ttgattattt 1651681 cacacaacga agagaggagt tcgtaattgt atgggacaag aaaaacatgt ctttaccata 1651741 gattgggccg gaagaacgct taccgttgaa accggccagc ttgccaaaca ggcaaatggt 1651801 gctgtgatga tccgctacgg tgatacagca gtacttagta cagcaaccgc ttcaaaagaa 1651861 cctaaaccgc ttgatttctt ccctcttact gtaaactatg aagaaagatt atatgcggta 1651921 gggaaaattc cgggcggatt tattaaaaga gaaggacgtc caagtgaaaa agcggttctt 1651981 gccagccgtt taattgaccg tccgatccgt cctttgtttg ccgatggatt ccgtaatgaa 1652041 gttcaagtca tcagcattgt catgagtgtt gaccaaaact gctcttcaga aatggctgcc 1652101 atgttcggtt catctcttgc actttctgta tcggatattc cgtttgaagg accgattgca 1652161 ggggttactg tcggacgcat tgatgatcaa tttatcatta acccgacagt cgatcagctt 1652221 gaaaaaagcg atatcaatct tgtcgttgcc ggcacgaaag atgcgattaa catggtagaa 1652281 gcgggagcgg acgaagttcc tgaggaaatc atgcttgagg ccattatgtt cggccatgaa 1652341 gagattaaac gcctgattgc attccaagaa gaaattgttg cagcagtcgg caaagagaaa 1652401 tctgaaatta agctctttga aattgatgaa gagcttaatg aaaaagtaaa agctttggca 1652461 gaagaggatc tgctgaaagc catccaagtt catgaaaagc atgcccgtga agatgccatt 1652521 aacgaagtga agaacgcagt tgtggcaaaa ttcgaggatg aagaacatga tgaagacaca 1652581 atcaagcaag tgaagcagat tttatccaag cttgtgaaaa atgaagttcg ccgcctgatt 1652641 actgaagaga aagtaagacc ggacggccgc ggtgtcgatc aaatccgtcc gctctcttca 1652701 gaggttggcc tcttgccaag aacgcacggt tcaggtctat ttacaagggg acaaactcag 1652761 gccctcagcg tatgtacgct aggtgctctg ggagatgtgc aaatccttga cggcttaggt 1652821 gtcgaagagt cgaaacggtt tatgcatcat tacaacttcc cgcaattcag cgttggggaa 1652881 acaggaccga tgcgcggacc gggacgtcgt gaaatcggac acggagcact gggtgagcgt 1652941 gcgcttgagc cagttattcc gtctgaaaaa gacttccctt atactgtccg tcttgtttca 1653001 gaagtgcttg aatcaaacgg ttctacatct caagcaagca tttgcgcaag cacacttgca 1653061 atgatggatg ccggtgtacc gattaaagcg ccagttgctg gtattgcgat gggtcttgtc 1653121 aaatcaggcg aacattacac tgtcttgact gacatccaag gcatggaaga cgcgctcgga 1653181 gatatggact ttaaagtagc gggaactgaa aaaggcgtaa cggccctgca aatggacatt 1653241 aaaattgaag gcctttccag agagattctt gaagaagcgc ttcagcaggc gaaaaagggc 1653301 agaatggaaa tcctcaacag catgcttgca acattaagcg aatcaagaaa agagctttct 1653361 cgatatgcgc ctaagatctt aacaatgacc attaatcctg ataaaatccg cgatgtcatc 1653421 ggaccaagcg ggaaacaaat caataagatc atcgaagaaa ccggtgttaa aattgatatt 1653481 gagcaggacg gcacaatctt tatttcctct acagatgaaa gcggcaacca aaaagcgaaa 1653541 aaaatcatcg aagaccttgt gagagaggtt gaagtcggcc aactttacct aggtaaagtg 1653601 aaacggattg aaaaattcgg ggctttcgtt gaaattttca gcggaaaaga cggtttggtg 1653661 cacatttcag agcttgcgct tgaacgcgta gggaaagttg aagatgttgt gaaaatcgga 1653721 gacgagattc ttgtcaaagt cactgaaatt gataaacaag gacgagtgaa tttatcccgc 1653781 aaagcggtgc tccgtgaaga gaaagaaaaa gaagaacaac aatcttaaat gaaaacataa 1653841 aaggagcctg ggagacccgg cttctttatt ttgaagcttt tcaaaagcag gcgggttcta 1653901 ccttgtcctt ctccttcata atgtgaggtg agggggggac agaacatgta caaaaaattt 1653961 gtaccgtttg ccgttttttt atttcttttt tttgtctcat ttgagatgat ggaaaatccg 1654021 catgcacttg attatatagg ggcaatgaaa aaagatacgg tgactgtcac ggcgtcaaaa 1654081 gacccgttat atgaagaatt gcttcaaaaa gcgccggagt acgaagttaa gccccagaat 1654141 gcaagaattg ataaagtgtg gaaaagcatt ccaggctaca atggattaaa ggtcaatatt 1654201 gaacaatcat ataaaaaaat gaaacagcat ggtaagtttc gggaaaaaga tttggtgtac 1654261 agtcaagtaa aaccaagtgt tcatcttgag tcacttcagc ctgagcctat ttataaagga 1654321 aatcctgaca aaccgatggt ggctttttta atcaatgtgg catggggaaa tgagtatttg 1654381 gaaaaaatgc ttcctattct gcaaaagcac caggttaaag ctacgttctt tttagaaggc 1654441 aattgggtga gaaacaatgt acagctcgct aagaagattg caaaagacgg acatgaaatc 1654501 ggaaatcatt catacaatca tccggatatg agcaaactga ctacaggaag aatttccgag 1654561 cagctcgaca agactaatga acaaatagaa caaacgatcg gcgttaagcc aaagtggttc 1654621 gctccgccaa gcggaagttt cagaaaagcg gttatcgaca ttgcagcaga gaaacagatg 1654681 ggaacagtca tgtggacagt tgatacaatc gattggcaaa agccggctcc gtctgtactt 1654741 cagacgagag tgttaagcaa gatacataat ggtgccatga ttttaatgca tccgactgac 1654801 cctacggcgg aaagtcttga agcgctgatt acacagataa aagacaaagg atatgcgctt 1654861 ggaacagtca ctgaactaat ggatgaaaca agactattga agtaacagat gaaggcagct 1654921 tgtctttgaa taggaggaac aaatttgatt aaacgatata cgtgtcaaaa tggtgtaaga 1654981 attgtgctgg aaaataaccc gacagtccgt tctgttgcga tcggcgtatg gatcggcaca 1655041 ggttcgagac atgaaacgcc ggagataaac ggaatttctc actttttaga gcacatgttc 1655101 tttaaaggga cgagcacaaa atctgcacgc gagatagcag aatcttttga tcgtattggc 1655161 ggccaggtca atgcgtttac ttcaaaggaa tatacctgct actatgcaaa ggtgcttgac 1655221 gagcatgcga attacgcgct ggacgtatta gcagatatgt tctttcattc aacgtttgat 1655281 gaaaacgagc tgaaaaaaga gaaaaatgta gtatatgaag aaattaaaat gtatgaagat 1655341 gcgccggacg acattgtaca tgatttattg agcaaagcca cttacggcaa tcattcttta 1655401 ggctacccaa ttttaggaac ggaagaaacg cttgcttcct ttaacggtga ctctctcaga 1655461 caatacatgc atgattatta tacgccggac cgagtggtga tttcggtagc gggcaatata 1655521 tctgacagtt ttatcaaaga tgtagaaaaa tggttcgggt catacgaggc gaaaggcaaa 1655581 gcgacaggcc ttgagaagcc tgagttccac acggaaaaac tgacgagaaa aaaagaaaca 1655641 gagcaggctc atttgtgcct tggatttaaa ggcttagagg ttggccatga acgtatttat 1655701 gatttaatcg tcctcaacaa tgtgctcgga ggcagcatga gcagccggct gttccaagat 1655761 gtgcgtgaag ataaaggact tgcttattct gtttacagct atcacagctc atatgaggac 1655821 agcggaatgc taacgattta cggcggaacg ggtgcaaatc agcttcagca gctgtcggaa 1655881 acaattcaag aaaccctggc cacattaaaa cgtgacggca ttacctcgaa agaactggaa 1655941 aacagcaaag agcaaatgaa gggaagctta atgctgagct tagaaagcac aaacagcaaa 1656001 atgagccgaa acggaaaaaa tgaactgctg ctcggcaaac ataaaacatt agatgaaatt 1656061 atcaatgaat taaacgccgt gaacttagag cgtgttaatg gccttgccag acaattgttt 1656121 accgaagact atgcattagc acttatcagc ccttccggca atatgccgtc ttaaaaagga 1656181 aagcctgccc cataatggag caggcatttt ttaatccctt tcatcataca tagtacaagg 1656241 gggtgacaga catgcggctc agtgaattat cgggaaagga aattgtagac atcaaaagag 1656301 ctgaacggct cggagtgctc ggccagaccg atttggaaat caatgaacag gatggacaga 1656361 ttacagcact cctcattccc acagttaagt ggtttggttt gagaaagcaa ggtcatgaca 1656421 ttcgtgtccc atggcaccat attcaaaaga tcggttcaga tatgattata ttagatgtac 1656481 ctgaggaaat gcctcctcga caagagtaaa tagcccaatt gactgtgaag cgggctctaa 1656541 agaaaacatc tgaaacatcg gctgccggag ccgatgtttt tttatatgga aaaagcgcat 1656601 cttttatatt caccggtatt tccttttgat cataagatga aggggagctt aacaactaga 1656661 gatccagtat atacaaagaa ggtgaacgtt tagaatgtta accggattga aaattgcagt 1656721 tatcggcggt gacgcaagac agctcgaaat tataagaaag ctcactgaac agcaggctga 1656781 catctatctt gtcggttttg accaattgga tcacggtttt accggggcag taaaatgcaa 1656841 tattgatgaa attccttttc agcaaataga cagcatcatt cttccagtat ccgcgacaac 1656901 aggagaaggt gtcgtatcga ctgtattttc gaatgaagaa gttgtgttaa aacaggacca 1656961 tcttgacaga acgcctgcac attgtgtcat tttctcagga atttctaacg cctatttaga 1657021 aaacattgca gctcaggcaa aaagaaaact tgttaagctg tttgagcggg atgacattgc 1657081 gatatacaac tctattccga cagtagaagg aacgatcatg ctggctattc agcacacgga 1657141 ttatacgata cacggatcac aggtggccgt tctcggtctg gggcgcaccg ggatgacgat 1657201 tgcccgtaca tttgccgcgc tcggggcgaa tgtaaaagtg ggggcaagaa gttcagcgca 1657261 tctggcacgt atcactgaaa tggggctcgt tccttttcat accgatgagc tgaaagagca 1657321 tgtaaaagat atagatattt gcattaatac cataccgagt atgattttaa atcaaacggt 1657381 actttctagc atgacaccaa aaaccttaat attggatctg gcctcacgtc ccgggggaac 1657441 ggattttaaa tatgccgaga aacaagggat taaagcactt cttgctcccg ggcttccagg 1657501 gattgtcgct cctaaaacag ctgggcaaat ccttgcaaac gtcttgagca agcttttggc 1657561 tgaaatacaa gctgaggagg ggaaataagg atgtcgtcat taaaaggaaa aagaatcggg 1657621 tttgggctga ccgggtcgca ttgcacatat gaagcggttt tcccgcaaat tgaggagttg 1657681 gtcaacgaag gagctgaagt ccgtccggtt gtcacattta atgtaaaatc tacaaatacc 1657741 cgatttggag agggcgcaga atgggttaaa aaaattgaag acctgactgg atatgaggcc 1657801 attgattcga ttgtaaaggc agaacctctt gggccgaagc tgccccttga ctgcatggtc 1657861 attgcgcctt taacaggcaa ttcaatgagc aagctggcaa atgccatgac ggacagcccg 1657921 gtgctgatgg cggcaaaagc gacaatccgg aacaatcggc ctgtcgttct gggtatctcg 1657981 acaaatgatg ctcttggttt aaacggaaca aatttaatga ggctcatgtc aacaaaaaat 1658041 atctttttta ttccattcgg gcaagatgat ccatttaaaa aaccgaattc aatggtagcc 1658101 aaaatggatc tgcttccgca aacgattgaa aaggcactca tgcaccagca gcttcagccg 1658161 attctagttg agaattatca gggaaatgac taaatttaca gaaaatcttt cccaaactaa 1658221 aaaattcggt catcacccgc atattctatg gtaaaataaa acgtaaaatc atagtcaaat 1658281 caattcaatg aagctgattg gcggaaggag ttttacagat gggaagaggt ttacacgtag 1658341 ctgttgtcgg agcgacaggg gctgtgggac aacaaatgct taaaacactt gaagacagaa 1658401 actttgaaat ggacacactt acattgctat cttcaaaacg ctctgcgggg acaaaagtca 1658461 cgtttaaagg ccaagagctg actgttcagg aagcttctcc tgagagcttt gaaggggtaa 1658521 atattgcttt gttcagcgcc ggcggaagcg tatcacaagc attggcacca gaagctgtaa 1658581 aacgcggcgc tattgttata gataatacga gtgcgttccg catggatgaa aatacaccgc 1658641 ttgttgtgcc agaagtgaat gaggcagact tgcatgaaca caacggcatt attgccaatc 1658701 caaactgctc tacaatccaa atggttgcgg cacttgaacc gatccgcaaa gcatatggct 1658761 taaacaaggt catcgtatca acttaccagg cagtatcagg agcgggtaat gaagctgtaa 1658821 aagagcttta cagccaaaca caggcgattt taaataaaga agaaatagag cctgagatca 1658881 tgcctgtaaa aggtgacaaa aaacactatc aaatcgcctt caacgcgatt ccgcaaatcg 1658941 ataaattcca agataacggc tatacgtttg aggaaatgaa aatgataaat gaaacgaaaa 1659001 aaatcatgca catgcctgac cttcaagtag cggctacatg tgtgagactg ccaatccaaa 1659061 ctgggcactc agagtccgtc tacatcgaaa tagaccgtga tgacgctaca gttgaagata 1659121 ttaaaaatct attgaaagaa gctccgggcg tgacacttca ggatgatcca agccagcagc 1659181 tttatccgat gcctgctgat gctgtcggca aaaacgatgt gtttgtaggc cgcatccgca 1659241 aagacttgga cagagcaaac ggttttcatt tatgggttgt ttctgataac ctattaaaag 1659301 gcgcggcatg gaactctgtt caaattgcag aaagcctgaa aaaactaaac ctcgtataaa 1659361 agagagaatt ttctaaagac gaatagaaga gagtaaggcg ctatcagcct gctctcttct 1659421 gttacgtccg aataatttgg agtgaaaaca gtgaagataa ttgttcaaaa gttcggcgga 1659481 acatcagtaa aagatgataa aggccgcaaa ctggctttag ggcatattaa agaagcaatc 1659541 agtgaaggat ataaggttgt cgttgtcgtt tcagcgatgg gccgaaaagg ggacccgtat 1659601 gcaacagatt ctttgctcgg gctgctttac ggcgatcagt cagcgatttc tcctagggag 1659661 caggatttgc ttttatcttg cggagagact atttcctctg tcgtctttac aagcatgctg 1659721 cttgataacg gtgtgaaagc agctgcgctg acaggggctc aggctggctt tttaacgaat 1659781 gatcagcata ctaatgcgaa aatcattgaa atgaaaccgg agcgtttatt cagtgtgctc 1659841 gccaatcatg atgcggtagt cgtcgcaggc ttccagggcg caactgaaaa gggtgataca 1659901 acaacaatcg gcagaggggg cagcgatacg tctgcagccg cactcggagc agctgttgat 1659961 gcggaataca tcgatatttt caccgatgta gaaggcgtga tgactgctga cccaagagtg 1660021 gtagaaaatg caaaaccgct tcctgttgtg acgtatacgg aaatctgcaa cctggcgtat 1660081 cagggggcca aggtcatttc tccgcgtgct gtggaaatcg caatgcaggc caaggttccg 1660141 atccgcgtcc gttcgactta ttcgaatgat aaaggcacat tggtgacatc acatcactct 1660201 tccaaggtcg gcagtgatgt ttttgaaagg ctgattacgg gaatcgccca tgtcaaagat 1660261 gtcacgcagt tcaaagtgcc tgcgaaaatc ggccagtata acgttcagac tgaagtgttc 1660321 aaggctatgg caaacgctgg aatcagtgtc gatttcttta acattacacc tagtgaaatc 1660381 gtctatacgg tagccggaaa taaaacagaa acagctcagc gtattttaat ggatatgggc 1660441 tatgatccaa tggtgacgag aaactgcgcg aaggtatcgg cggtcggcgc gggcattatg 1660501 ggtgttcccg gtgttacgtc caaaattgta tcggctcttt cagaaaaaga aattccgatc 1660561 cttcagtcgg ctgacagcca tacgacgata tgggtgctcg tccatgaagc ggatatggtt 1660621 cctgctgtaa acgctttgca tgaagtgttt gaactttcga agtaaatgtg attgaatcat 1660681 gatgaggtga ataaaatgaa tttcggaaat gtgtctacag cgatgattac accctttgac 1660741 aataaaggga acgtagactt tcaaaaactg tctacactga ttgattactt gttgaaaaac 1660801 ggaacggatt ctttagtagt agcgggaaca actggagaat ctccgaccct ttcaactgaa 1660861 gaaaaaattg cgctttttga atatacggta aaagaagtaa acggacgggt gcccgttatc 1660921 gctggtactg ggagcaacaa cacgaaagat tccattaagc tgacaaaaaa agctgaggaa 1660981 gcgggcgtgg acgctgttat gcttgttacc ccgtattaca ataaaccttc tcaagaagga 1661041 atgtaccagc attttaaagc aattgcggca gagacatctc ttccggttat gctctataat 1661101 gttcctggcc gtacggttgc ttctcttgct cctgaaacga cgatccgttt ggcggcagac 1661161 attccgaatg tggttgcgat taaagaagcg agcggagacc tcgaagcgat tacaaaaatt 1661221 attgctgaaa cacctgaaga cttctatgtc tattcagggg atgatgctct aacgcttcca 1661281 attctttcag ttggaggtag aggagttgtg tcagtggcga gccatattgc aggcactgat 1661341 atgcagcaaa tgatcaaaaa ttatacgaat gggcaaacag ctaatgcggc actgattcat 1661401 cagaaactgc tgccgattat gaaggaactg tttaaagcgc ctaatcctgc tccagtcaaa 1661461 acagcgcttc agctgagagg tcttgatgtc ggttctgtgc gtctgcctct agtcccatta 1661521 actgaggatg aacgtctgag cttaagcagc acgatcagcg aactgtaaga aaatttcata 1661581 cagtgaaaca aacgcggtca ttctcacatt cagctgagtt tgaccgtttc ttttacatat 1661641 tggttttccc taaaccttct gctttatctt gttttctaaa tttactttca gttataatag 1661701 gaacaagtga tgatggacgg gtatgagact aggaggatat agattttgaa aaagaaaaat 1661761 acagaaaacg ttagaattat cgcccttggc ggtgtcggag agattgggaa gaacctttat 1661821 gtcattgaaa ttgactcaga catatttgtc gttgatgccg gccttatgca tccagaaaac 1661881 gaaatgctcg gtattgatgt agtgattcct gacatatcat atttgattga acgggctgac 1661941 cgcgtcaagg caatcttttt aacgcacggg cacgatgaaa atatcggcgg cgttttttac 1662001 ttattaaaca agctgtccgt tccagtgtac ggaacaaaac tgacgcttgc actgttaaga 1662061 gagaaattaa aacaatacgg acataaccga aaaactgatt taagagaaat tcactccaaa 1662121 tctgtcatta catttgaatc aacaaaggta tcgttcttta gaacgattca cagcattcct 1662181 gattctgtag gtgtgagctt taaaacatca cttggatcta ttgtatgcac gggagacttc 1662241 aaatttgacc aaacacctgc acttaatcag acgtgcgaca ttggcgagat cgccaagatc 1662301 ggcaatagcg gcgtgctcgc tctgctttct gacagtgcaa atgcggaacg gccgggttac 1662361 accccttcgg aagcggctgt cagcggagaa atttcggatg cgctgtataa ttcacagaac 1662421 cgggtgatta ttgctgtttt cgcatccaat attaaccgga ttcagcaagt cattcatgca 1662481 gcggctcaaa atggcagaaa gattgccgta gccggaaaaa atcttcaatc tgtcctgcag 1662541 ctggcgagaa agttaggata tattgaagca gatgatgaat tgtttatttc tgtacaggat 1662601 gtcaaaaaat atccgaagcg cgaagtggcc attattacag ccggaagcca aggtgaacca 1662661 ttagctgctt tgacaagaat ggcaaacaaa gctcacaaac agctgaacat tgaagaaggg 1662721 gatacggtgg tcattgcgtc aactccgatt cccgggcagg aactcattta ctctaaaaca 1662781 gtagatcttc ttgcgagagc cggtgcacaa gtcatctttg cccaaaagcg tgttcatgta 1662841 tcaggccacg gctcacaaga agagttaaag ctgatgatca acctgcttaa accaaaatat 1662901 ttgattcctg taaacggcga atacagaatg caaaaagctc attcaaaaat cgctgaagaa 1662961 accggcatga agcgcagtga catcttctta attgaaaaag gcgacgtcgt tgaattccgc 1663021 ggccaaaacg taaaaattgg ggataaagtt ccttacggca atattttaat tgatggttta 1663081 ggtgtcggtg atatcggcaa tatcgtattg agagaccgcc gcttgctttc acaggacgga 1663141 attttaatcg ttgtcattac acttgataaa caaaagaaac atcttgtatc aggaccagaa 1663201 attatcactc gcggctttgt ttatgtaaga gagtctgaag gtcttatcgt acaggctact 1663261 gagcttgtac ggtccatcgt gacagaagcg actgaaacat caaatgtcga atggtcaacg 1663321 ctgaagcagg caatgcggga tgctttgaac caattccttt atgaaaaaac gaaacgtaaa 1663381 ccgatgatca tcccaattat tatggaagta taatgactga ctaaagaccg gagctgctcc 1663441 ggtctttatt ttttgtcctt caagccggga ttgaatgaag tatctttgtt cataatacaa 1663501 agagaaactc ggaaaggatg aaagcgagat ggatcatcgt atggaaaaca cagaagaaga 1663561 gcgtcctgaa aaaaatgatg cgaaggacag cattatgaat aaaatacagc agcttggtga 1663621 aacgacgctt ccgcagctgc cccaagatac aaatattcat tgtctgacca ttatcggaca 1663681 aattgaaggc catgttcagc ttcctccgca aaacaaaaca acaaaatatg aacatgtcat 1663741 cccgcagatt gtggcaattg aacaaaatcc caaaattgaa ggcttgctga tcatattaaa 1663801 tactgtcgga ggagatgttg aagctggtct tgccatagcg gaaatgcttg catctttatc 1663861 gaaaccgacc gtttctatcg tgcttggcgg ggggcattca atcggcgttc cgattgctgt 1663921 atcctgtgat tacagctata tcgccgaaac agcaacgatg acgattcatc cagttaggct 1663981 caccgggctg gtcatcgggg tgccgcaaac gtttgaatac ctggataaga tgcaagaaag 1664041 agttgttaaa tttgtgacaa gccattccaa tataaccgaa gagaagttta aagagctaat 1664101 gttttcaaaa ggaaacttaa cacgcgatat cggaacaaat gtagtcggta aggatgcagt 1664161 taaatacgga ttgatcgatc acgcaggcgg tgtcggacag gcaatcaata aactgaatga 1664221 gctcatcgat gaagcaagga aagaagaagg acggatgatt caatgattct ttataccgtg 1664281 atgcctcagg aaattgtgtt tgcagaacag aaccaagaga caagcgcaca tgagcaaatt 1664341 gaatataaag gtgtaccgct tctagtcgaa atgaaaggga atgaagcgga agtcattcaa 1664401 atcatgagca ccaatccaat gcattttctg catccggaca tttcaccggg acaaaagctg 1664461 aaattaaacg tataagaatc caaccctttt ttaagggcaa aatatgctat aataggggaa 1664521 tcctacagaa aaaacgcagc ctgtaaacgg ctgctttctt cattatgtat gaacttacat 1664581 tttttaacgc agtaaggtga tgagtgtggc aaagaaaaaa cgaaaatcaa gaaaaaaaca 1664641 ggcgaaacag ctcaatataa aatacgagct caacggattg ctgtgtatag ccatttcaat 1664701 tatcgcaatc ttgcagctgg gggtagtcgg gcaaacgttt atctatttgt tccgcttttt 1664761 tgctggagag tggtttattt tatgcttgtt aggtttattg gtgttaggag tctcactgtt 1664821 ttggaagaaa aaaaccccaa gccttttaac gagacgaaag gccgggttgt actgtattat 1664881 cgcaagcata ttgctgcttt ctcacgtgca gctatttaaa aatttgacgc acaaagggtc 1664941 tattgagtct gcaagcgtgg tgcgcaatac gtgggaattg tttttaatgg acatgaatgg 1665001 cagctctgct tcacctgatt taggcggagg gatgatcggt gcgctgctgt ttgcggcttc 1665061 acactttttg tttgcgtcga ctggttctca gatcatggca attgtcatga ttttgatcgg 1665121 aatgatttta gtaacaggac gctcgctgca agaaacgcta aaaaagtgga tgagcccgat 1665181 tggacgtttt ataaaagaac aatggttagc atttattgat gacatgaaat ccttcaaatc 1665241 aaatatgcag tcatcgaaaa aaacgaaagc gccgagcaaa aaacaaaaac cggcccgcaa 1665301 aaaacagcaa atggaaccgg agcctcctga tgaagagggg gattatgaaa cagtatcgcc 1665361 tcttattcat tcagagccga ttatctcaag cttttctgat cgtaatgaag aggaagagtc 1665421 tccagttata gaaaagcgcg ccgaacctgt gtcgaagccg cttcaggaca tccaaccgga 1665481 gacaggtgat caggaaactg tttctgctcc tcctatgacc tttacagagc tcgaaaataa 1665541 ggattacgag atgccgtcac tggatttgct ggcagatccg aagcataccg gccagcaggc 1665601 tgataaaaag aatatttatg aaaatgcgag aaagcttgaa cgcacattcc aaagctttgg 1665661 cgtaaaggcg aaagtcacac aggttcatct cggaccggcc gtaacaaaat atgaagtata 1665721 tcctgatgtc ggagtgaagg ttagcaaaat tgtcaattta agcgatgatt tagcgcttgc 1665781 gcttgctgcg aaggatatca ggatcgaagc gcctatacca ggcaaatcag caatcggaat 1665841 tgaagttcca aacgcagaag tggcaatggt ttcgctgaaa gaagtgctgg agtctaaatt 1665901 gaatgacaga ccggatgcga agctgttaat tggactcggc cgcaatattt caggtgaagc 1665961 tgtattggct gagttaaaca agatgcccca ccttttggtc gcaggcgcaa ccggtagcgg 1666021 gaaaagtgtc tgtgtcaacg gcattattac aagtatttta atgcgggcga aaccgcatga 1666081 agtgaaaatg atgatgatcg atcctaaaat ggtagagcta aatgtctaca acgggattcc 1666141 gcatttgctt gctcctgttg taaccgatcc gaaaaaagcg tcgcaggctt tgaaaaaggt 1666201 tgtcaatgaa atggagcggc ggtacgaatt attttctcat acgggtacaa gaaatattga 1666261 aggatacaat gattatataa aacgcgccaa caatgaagaa ggagcgaaac agccagagct 1666321 gccttatatt gttgtcattg tggacgagct agccgatctc atgatggtcg cttcatctga 1666381 tgtggaagat tcgattacga gattgtccca aatggcgcgg gctgccggca tccatcttat 1666441 tattgcgaca cagcggccat cggtggatgt tatcacaggg gtgatcaaag cgaacattcc 1666501 gtcacgaatc gcgttcagcg tatcttcaca gacggattca aggaccattc ttgacatggg 1666561 tggcgctgag aagcttcttg gccgcggcga tatgctgttt ttacctgtag gggctaacaa 1666621 acctgtccgt gtgcagggag catttttgtc ggatgacgaa gtggagaagg tcgtcgacca 1666681 tgtgattact cagcagaaag cgcaatatca agaagaaatg attcctgagg agacgacgga 1666741 aactcattcc gaggttactg atgaacttta tgatgaagct gttgaattaa tcgtcggcat 1666801 gcagacggca tctgtttcaa tgctgcaaag aagattcaga attggctata cgagagcggc 1666861 gcgcctgatt gacgcaatgg aggaacgcgg tgttgtcgga ccgtatgaag gcagcaaacc 1666921 tagggaagta ttattatcaa aagagaaata tgatgagctc tcttcttaat gaagggagtt 1666981 ccgctttcta tagttgtcaa taatgatatt atgtaaactg atcacctttc tatttatttt 1667041 ttcgacaaaa catgatatag ttgtcccaat tgttcaataa tttttatcga aagtggttta 1667101 cggaggggaa acatgtctac aaaagctgat aatcggcact tgtatttgaa agtaattgaa 1667161 cgaattaaag aggatataaa aaatgggatc tacactgaga aggaaaagct gccttctgaa 1667221 tttgagcttt ccaaaaagct tggtgtcagc agagcgacgc taagagaagc cttgcggata 1667281 ctggaagaag agcatgtgat tatcagaagg catggtgtag gcacttttgt ccattctaag 1667341 ccgttatttc tttcgggtat tgaacagctg aacagtgtaa ccaagatgat agaacaggcg 1667401 aatatgaccc ctggcacgat ttttctatca tcacaagtgc ttatgccgtc tgaagatgat 1667461 acgaagagat ttcacttggc agaagggcaa gaactttttt accttgaacg agtcaggaca 1667521 gctgacggac agccgattgt gtattgtata gacaaaattc cgatgaatat tttgccgaat 1667581 tctttttctc atcagcaaga atctatgttt gacctgctag agaaaaattc aggctccgta 1667641 atcagctatg cagtaactga tatagaaccg atcggctatc acgataccat ttctccagtg 1667701 cttgaatgcg atccggaaac agctcttttg ctgttaaaac aaacccatta cgatcagcac 1667761 gataaaccgg tgctttattc tttaaattat tttagagcgg ataaattcag atttcatgtt 1667821 ttgcgtaaac gattctaaaa acggacgcct gtatgtgtct gtttttttat ttgcactgat 1667881 tcatgtttct ttgtacatac tttcattccg gttaacgcaa tatataaggg atgacaagaa 1667941 agtgaatggg tgaaaatgtt gagagagaaa aatggaatga aaaatattat tgcattgtct 1668001 tctgtcccgc ttgtgatgac actcgggaac tccatgctga ttcctgttct tccgatgatg 1668061 gagaaaaagc tgtctgtgac ttcatttcaa gtatctttaa tcattactgt atattcagta 1668121 gtagcaatta tttgcattcc gattgccgga tatttgtcgg atcgtttcgg gagaaaaaaa 1668181 atattgcttc catgcctcct cattgcagga ttggggggag ccgtagctgc ttttgcctcg 1668241 acctatatga aaaatcctta tgctatgatc ttggcggggc gggttcttca aggcattggt 1668301 tctgcaggtg ccgctccgat tgtcatgccg tttatcggcg acctgtttaa aggagacgat 1668361 gaaaaggtca gcgcgggtct tggcgatatt gaaaccgcca acacgtcagg gaaggtactg 1668421 agtcccatac ttggagcctt actggcttct tggtattggt ttgtaccgtt ttggtttatt 1668481 ccgtttttct gtttgatcag ctttttgctc gtattgtttt tggtggccaa gcctgaagaa 1668541 gatgaagatg cgcctgctgt ttctgagttt attaagagtg tgaagaaaat ttttaaacag 1668601 gatggtcgct ggctttatac ggtcttcatt atcgggtgtg tcattatgtt tttgttattt 1668661 ggcgtattat tttatttatc agatacgctg gagaacaagt atgctattga cggagtagct 1668721 aaaggcggat tactggcaat cccacttttg tttttgtcaa ccagttcttt tatagctggc 1668781 aaaaagatcg gtaaagataa aggccgaatg aaattttgcg ttgttacagg aatgattctg 1668841 ttaacccttt cgtttattgc cttgtggtgg aaccacagtt tttatttttt atttgtcttt 1668901 ttaagctttg gcgggattgg gattggaatg gctcttcctg ctttagatgc attgataacc 1668961 gaagggattg aaagtgaaca atgcggaacc atttcctcct tttacaatag catgcgcttt 1669021 ataggagtag ctctcggtcc acctgttttt gctgcattaa tgtctaatgc aaactggatt 1669081 attttcatac tctcggcgtt ttgcagcatc gtttctttat ttttagtgct ctttactgta 1669141 gatgctaaaa aaagtgaaga agaaaaaaac ttagggacgg tctagccagc cgtctttttt 1669201 tgcgctttct tgcacagttt acaactgtac ctatacagca tgcggaggtt attgtttcct 1669261 tataaatcct acagttgcta taattacatg aaagagtgtt tctgcggatg ctgaaaattg 1669321 gtcataatac atactaatta agaaatgaac gaaggaggtt ccatatgtca tatgttaatg 1669381 aactcaaatc aaagcacggc ggtttaaccg cacacattgt aaaaacagaa aaattcaaaa 1669441 ccgtctcgct tatttttaag atgcttgcgc cgctgacaaa ggatcaagtc accaaaagag 1669501 cgcttctccc gcatgtgctt cttcgcggaa cgaaaagcca tccgaaaacc gcaggattgc 1669561 gttcatactt ggatgagctg tacggcacgt cagtatcggc tgatcttacg aaaaaaggag 1669621 agcggcatgt cattacgttc aggcttgaaa tcccgaatga aaaatattta aaagaccaaa 1669681 cgccgcttct cgagaaaggg ctccagcttc tcgcagaact cgtcttttca cctgctttgg 1669741 agggagacgc ttttcagtca caatatgtgg ctcaagaaaa acggacgctt aagcaaagaa 1669801 tccaagccgt ctatgatgat aaaatgcgtt attcgaattt aaggctgata caggaaatgt 1669861 gcaaaaatga tccttacgcg cttcatgtca atggtgaaat cgacgatgtc gatgacatta 1669921 cggcagagca attatacgaa acataccaaa gcgctatcca aaaagaccag cttgatctat 1669981 atgttgttgg cgacgtggac agtaaccagg tacaatcggc aattgataag tatttcaaaa 1670041 cagaagagcg cactcttggc atgattgaaa acaatcacgc tgatgaaaaa gttcagccaa 1670101 aagaagtaat tgatgaagag gatgtcaagc aaggaaaact gaatatcggc taccgcacca 1670161 gcatcactta tacagatcag gattatcctg ctttacaagt gtttaacgga ttgttcggcg 1670221 gattctctca ttctaaactt ttcattaatg ttcgggaaaa agccagtctt gcttactacg 1670281 cggcttcgcg tatagaaagt tttaaaggct tgttaatggt gatgtcaggc attgaagtga 1670341 aaaattttga acaggcggtt tcgattattg ctgagcaatt ccaggcaatg aaaaatggcg 1670401 atttcagtga gcaggatata gcacagacaa aggccgttat tcgaaatcaa gtgctggaaa 1670461 cgattgatac agcatacggt ttatctgagt ttttatatca gcaggccgct gctcaagtcg 1670521 agattcctat cgaagacttt cttgccaata ttgagaatgt cacaaaagag gatatcatta 1670581 aagccggcga aaagattcag cttgatacga cttatttctt aaaagggacg gagggtgcat 1670641 cttgatcaaa ccaatcgaat atgaacagct tcaggagacg ctgtatcatg aaaaaatgtc 1670701 caacggcctt gatgtttacg ttttgccgaa aaaaggcttc aacaagacat atgcggtctt 1670761 tacaacaaag tacggctcga tagataaccg gtttgtccct ttaggtaaaa acgagatggt 1670821 tcacgtgccg gacgggattg ctcactttct tgagcacaag ctgtttgaga aagcggacgg 1670881 agacgttttt caagatttca gcaaacaggg ggcttctgcc aatgcgttta cgtcatttac 1670941 aagaacggct taccttttct caagcacatc aaatgttgaa cgcaatttag agacgcttat 1671001 cgatttcgta caggacccat attttactga aaaaacggtt gaaaaggaaa aagggattat 1671061 cgggcaggag attaatatgt acgacgataa ccctgattgg aggctttact tcggggtcat 1671121 tgaaaacatg tacaaagagc atcctgtcag aattgacata gcgggaacag tggaaagcat 1671181 ttcacatatt acaaaagacc ttctttatga atgctatgaa acgttttatc acccgagtaa 1671241 catgctcctt ttcattgtcg gccctgtaga tcctgaagcg attatttctc aggtaagaga 1671301 aaaccagggg aaaaagccgt atactgatca gccggagatc aaacgagaag aagtgaaaga 1671361 gcaagaagcg gttttccgaa aagaaaaaga gatcaaaatg aacgtgcagg gaccgaaatg 1671421 ccttgttggg ctgaaatcca aaaatccgtt taaattaggc aaagagctct taaagcatga 1671481 actttcaatg aacttattgc ttgaagctct ttttggcaaa agctctgccc agtatgaatc 1671541 actttatgaa aaaggatata ttgacgaaac gttcagcttt gattttactg ctgaatatgg 1671601 gttcggtttt gcggcgatcg gcggagatac gcctgagcct gatcaattgg ctgaagacat 1671661 ttcaagcatg cttttgcgcg ccggtgaact gattactgct gaaaagattg aacttgccag 1671721 aaagaaaaag atcggcacat tcttaaaagc gctgaattcc cctgaataca tcgccaatca 1671781 atttacccgt tatgcgttct tggatatgag cctgtttgat gttgtaacgg tactcgagca 1671841 gattaccctc gaggatgtcc agaacgtaat acaagaggaa atcgctgcag acagactgac 1671901 tgtctgcaag gttgttccta aatcataaac aaaacatccc tccagtgtga ggggtgtttt 1671961 tctgcggaaa gaaggaaaga ggatgaacaa aacagcacta atcaccggag caagcggcgg 1672021 cattggcaaa agcatcagcg aaacccttgc agctagagga tacaatctgc tgctgcatta 1672081 caatacaaat caaaacgcgg cagcggagct tgctgaaaaa ctaagtcaga tgtttggcgt 1672141 aaatgcggag atattacaag ctgacctgtc cgcgcaagat ggagcagata agctgacaag 1672201 ttcaattgtt cagccgattg atgcgattgt tttaaacagc ggacgaagcc attttgggct 1672261 gattacggat gtagataacg caacggtcca ggaaatggtt cagcttcatg tggcgagtcc 1672321 gtatatgctg acgagaaacc ttctgccagg catgattcgg aataaatcgg gagcgattgt 1672381 ggctgtcagc tcgatttggg gagagactgg agcatcctgt gaagtgttgt acagcatggc 1672441 aaaaggagct cagcattcat ttgtaaaagg attggctaag gagctggcgc caagcggaat 1672501 cagagtaaac gccgtagcgc cgggtgcagt tgatacaaat atgatgaatc aatttacccc 1672561 ggctgaaaaa gaagagatcg ctgatgagat tccgatcggc cggctggccc ggccgcaaga 1672621 aattgcggat gcaacagctt ttctcctgtc tgaaaaagcg tcatatatca ccggccaaat 1672681 tctgtcggtg aatggcggct ggcactgctg atccgaaaat attcggtgta tagtttcttt 1672741 tgcgaaggac acaataatct tgtaacttca catgaaatgg aggaaacaag catgtcagta 1672801 ttagaaaact gggatagctg gaaaaacttc cttggcgacc gtctgaacta tgcgcaagat 1672861 aaaggtatga gccaggatac gattacagat cttgcgacag aaatcggcag ctacttggct 1672921 aatgaagtgg aatctaagaa cgagcaggaa aaagtgctgg cagatctttg gagtgtagca 1672981 tcaaaagatg aacagcacgc cattgccaat atgatggtta agcttgttga aaataacagc 1673041 actcactagg aagagagggg atttttcctc tcttttttat gttttcctca tcacagcaac 1673101 attcttcttt ctaattagag aaaaatgctt tatgataaag gaaggtaaaa ttttgccaca 1673161 atgaaggggg tatatcattt ggcaaagctc gaatggtatt ttgaatatga aattcaagtg 1673221 aaccgccccg gactgctcgg ggatatttca tctcttcttg ggatgctttc tatcaacatc 1673281 gtaacgataa acggcgtcga tctttccaga aggggaatgc tcctcaggtg ccgccatata 1673341 gatcaaatta aacgattaga atcaatctta aaaacgatgg aaacaattaa agtaacgaag 1673401 cttagagaac cgaggcttcg cgaccgtctt gccgtacgcc acggccgtta tattcaacgg 1673461 gatgccgatg acaagaaaac gttccgcttt gaacgggacg agcttggctt attagtcgat 1673521 tttatggccg aattgttcaa aaaagaaggc cataaattaa tcggaatcag aggtatgccg 1673581 cgtgtcggga aaacggaatc gattgtagcc tctagtgtgt gcgagcaaaa ggtggctgtt 1673641 tgtgtcatca accttgctga agcagacgat aagaagccag ctgattgccg atgaatacag 1673701 cactgaaaat gtctttatcg ttgacggaat tgtgtcaaca cgaagagggt cagaacgcca 1673761 tctccagctg gtccgagaaa tcatgcggct gcctgcaaca aaagtggtgg agcatccgga 1673821 catattcgtt caaaatacag agtatacact agatgacttt gattatatta ttgaactgag 1673881 aaatgaccct gatgaggtta ttacatatga acatgccgag gaaccccaaa tgtttgatca 1673941 atccgggttt tcaagctttg atttttaaaa ttggaaggtg tttgttgtga ctgaactagg 1674001 aatccggctc aaagaagcca gagaggaaaa agcaatgtca ttggatgatc tccaagcggc 1674061 aacaaagatt caaaaaaggt atttaaccgc cttggaggaa ggaaactatg acattattcc 1674121 ggggaagttt tatgttcggg cattcatcaa gcaatatgca gaagccgttg ggcttgatgc 1674181 ggatcagctg tttgaggagc ataaaaaaga tatccctaat acgtatcatg atgatgtgtc 1674241 tgaaaagatc tccggcatga atcttcaaaa ggaaatgcca aagccagcat ctaaggcgct 1674301 ggagctgctg ccaacaatac ttgttattct cggcgtgatt gtcgtgattg ccattgtgta 1674361 cgcgatcatt caatttgcca atcacaaaaa cagtgatgat cacaatgcgg catcagaaaa 1674421 agcaattacg caaagtgaga gcaagtacga aatccctaaa gattcaacgc tgaaagagaa 1674481 tcaaaataac agctctgaaa aagagacaga cactaaaaaa gaaacgaaag aaaacgaaga 1674541 taagaaaaaa gaaaatgaca gtgagaagct ggagattaaa gctgctggca ctgaaggatc 1674601 gttaacgact tatgaagtgt ccggcgctga taaaatcgag ctggaactga aggcatcaga 1674661 cagctcctgg attagagtgc gcgatgaaaa cagcagctct ttaaaagaag gaacgctgaa 1674721 aaaagacgaa acctataaaa aagacataac tgatcagaaa caagttgata tccgcaccgg 1674781 atatgcacct aatctgaaaa taaaaatcaa cggtaaggtt ctttcatatg aacttgatcc 1674841 gaaaaaagtg atggcacaaa ccataaagat tgtaaataaa aaggaagaaa agtcatctta 1674901 attaccagat gacttttctt cacgtccgag tatgaaattg gaggggcttt atgtttaact 1674961 taccaaataa aatcacacta gctagaatcg cattaatccc aatcttcatg attatcatgc 1675021 tggcgccgtt tgactggggc aggctcgaag ttggagacga atccatcccg gtcgcacatt 1675081 tggcgggggc cattctattt attattgcat ctacaacaga ctgggtggac gggtattatg 1675141 cccgaaaatt aaatctcgta acaaacttcg ggaaatttct tgatccgctt gcggacaaac 1675201 tgctcgtatc cgcagcgtta attatccttg ttcaatttga tctcgctcca gcttggatgg 1675261 tcattgtgat tatcagcagg gagtttgccg tgacaggttt aaggcttgtc ttagccggaa 1675321 caggagaagt cgtagctgct aacatgcttg gtaaaatcaa aacctgggca cagattattg 1675381 cggtatctgc attgcttctt cataatcttc catttgaact tgtgtcattc ccgtttgcag 1675441 acttggcgct gtgggtagcc gtcttcttta ctgtcgtctc aggctgggaa tatttctcta 1675501 aaaattggga agcgttaaaa acatctaact aagaaagaag gacttcgtca tggaatttcc 1675561 aaaaaaagca gaaataattg cagtcggttc agagttgctg cttggtcaaa tcgccaatac 1675621 aaatgctcaa tttatcagca aacagctcgc tgaaatcggg gtcaacgtat tttatcatac 1675681 agcggtcgga gataacccgg agcggctgaa gcaggtcatc cgcattgctg aagaacgctc 1675741 tgacttcatt attttttcag gagggcttgg acccacaaaa gatgatctga cgaaagaaac 1675801 gattgcaaat acgctgggac gtccgcttgt gttaaatgat gaggcattcc aatccattga 1675861 ggactatttc aaacgaacaa aacgcacgat gtcacctaat aaccgaaaac aggcgcttgt 1675921 gatcgaaggc tctgacgtgc tggcgaatca ctttggaatg gccccgggaa tgctcacaga 1675981 gcatgaatcg cgctattata tgcttcttcc tggaccgccg agcgaattgc gtccaatgtt 1676041 tgaaaacgag gcaaagcctc ttctgctgaa aaagatgggt tcaaatgaaa aaattgtgtc 1676101 aactgttctt cgctttttcg gtatcggtga atctcagctt gaagccgatt tggaagatat 1676161 tattgatgca caaaccaatc cgacaattgc gcctttggcg gctgatggag aggtgacgct 1676221 gcgtctgaca gccaaacacg ccgatgaaaa ggaaacagag cgtctgttaa aagaaacaga 1676281 ggccgttatc ttagagcgtg tcggtgaatt tttctatggt tacgatgata cttctcttgt 1676341 aaaagagcta tctatagcat gtaaggaaaa aggcataaca atttctgcgg cagaaagctt 1676401 taccggaggg ctgttttctg aatggctgac ggatcatagc ggtgcctcaa aattatttgc 1676461 cgggggcgtt gtttgctata caaacgacgt gaagcagaat gtgcttggtg tcaagaagga 1676521 aacattagat cgttttgggg cggtcagcaa ggagtgcgca tccgaactgg ctaagggtgt 1676581 tcaaaaactc actggcagcg atatcggcat tagctttact ggtgtagcag gacctgatgc 1676641 tcaagaaggg catgagcctg ggcatgtgtt tatcggcatt tccgcaaatg gtaaagaaga 1676701 ggttcacgag tttcactttg cgggctccag aacggggatc agaaaacgcg gcgctaaata 1676761 cggctgccat ttaatcttaa agcttttaga gcaaaaataa tattttcagc acattatcct 1676821 cctaagaaaa catgatttct ctgatacatt atgatatttt gataggaatc acgccaagaa 1676881 aaaatccgaa tatgcgttcg cttttttctt ggcaaatccc ttcaaacagg gtatagtata 1676941 tgtagtggta acataaagga ggaaaaaata gaatgagtga tcgtcaggca gccttagata 1677001 tggctcttaa acaaatagaa aaacagttcg gcaaaggttc cattatgaaa ctgggagaaa 1677061 agacagatac aagaatttct actgtaccaa gcggctccct cgctcttgat acagcactgg 1677121 gaattggcgg atatcctcgc ggacggatta ttgaagtata cggtcctgaa agctcaggta 1677181 aaacaactgt ggcgcttcat gcgattgctg aagttcagca gcagggcgga caagccgcgt 1677241 ttatcgatgc ggagcatgcg ttagatccgg tatacgcgca aaagctcggt gttaacatcg 1677301 aagagctttt actgtctcag cctgacacag gcgagcaggc gcttgaaatt gcggaagcat 1677361 tggttcgaag cggggcagtt gacattgtcg ttgtcgactc tgtagccgct ctcgttccga 1677421 aagcggaaat tgaaggcgac atgggagatt cgcatgtcgg tttacaagca cgcttaatgt 1677481 ctcaagcgct tcgtaagctt tcaggggcca ttaacaaatc gaagacaatc gcgattttca 1677541 ttaaccaaat tcgtgaaaaa gtcggtgtta tgttcgggaa cccggaaaca acacctggcg 1677601 gccgtgcgtt gaaattctat tcttccgtgc gtcttgaagt gcgccgtgct gaacagctga 1677661 aacaaggcaa cgacgtaatg gggaacaaaa cgaaaatcaa agtcgtgaaa aacaaggtgg 1677721 ctccgccgtt ccgtacagcc gaggttgaca ttatgtacgg agaaggcatt tcaaaagaag 1677781 gcgaaatcat tgatctagga actgaacttg atatcgtgca aaaaagcggt tcatggtact 1677841 cttatgaaga agagcgtctt ggccaaggcc gtgaaaatgc aaaacaattc ctgaaagaaa 1677901 ataaagatat catgctgatg atccaggagc aaattcgcga acattacggc ttggataata 1677961 acggagtagt gcagcagcaa gctgaagaga cacaagaaga actcgaattt gaagaataaa 1678021 aataaaataa gtttcaaatg atacaaaagg ctgagtgaaa aactcagctt ttttgtattt 1678081 tgcaaaaaaa tgataaaaat attgcttttt ttgacaactt ttttagggct ttattcgtct 1678141 aacaaaacgt gtgcaaaatg gaatttattt tgggaggaaa aaatgaatga caagcccaac 1678201 ccgcagaaga actgcgaaac gcagacggag aaaactaaat aaaagaggaa aactgttgtt 1678261 tggtctttta gcagtgatgg tttgcattac gatttggaat gctcttcatc gaaatagtga 1678321 agaaaacgaa ccatctcaag aaactgcagc ggtttcaaat accgatcaga aaaaagaggt 1678381 caaaaagaaa actgccaaaa aatcagagga acaaatcaaa acagtggatc gaaaccaaaa 1678441 aatcagcaat tatttaaaag agatcggttt cagcggaaca gccatgattg tcagaaatgg 1678501 agaaatcgta acaaataaag gttttggcta tgctgaccgt aaacactaca ttcaaaataa 1678561 tccattgaca tctttttatg tcggttcatc acaaaaagcg ctgattgcaa ctgctatttt 1678621 gcagcttgag gaaaagggga aacttcagac aagtgatccg gtaagcacgt atttacctca 1678681 ttttcccaac ggacaaacga ttactttgaa gaatctgctt acacatacat cggggataaa 1678741 cggacatatt gaaggaaacg gcgccattac tccggacgat ttaataaaag atatagaact 1678801 tcagggaatc aaacgtcagc cgggcgtatg ggactacaag gattccaact attctgttct 1678861 tgcttatatt attgctgaag taagcggtga gccctatgaa cagtacataa agaatcatat 1678921 ttttaaacct gcgggaatga cgcatgcagg cttttacaaa acatatgaaa aagaacctta 1678981 tcctgccgtc gggtataaga tggagggcag caaaacagtt acaccgtata tacctgattt 1679041 atcccagctg tatggagcgg gtgatattta tatgagcgct atagatatgt acaaatttga 1679101 ccaagcgctg atagacggaa aactgtattc gcaaaaaagc tatgaaaaga tgtttacgcc 1679161 agggagcagc tccacatacg gcatgggatt ttatgttgct cccggaagct attcaaacca 1679221 tggtgttatg ccgggcttca atatcttgaa cagctttagc aaatctgggc aaaccattgt 1679281 tattttgttc tcaaacattc aaaataatgc taaattgggc caagtgaaca ataaaatata 1679341 ccagcttcta aatcaagaat gattggcgat cttcttttgg atgaattgca ttcggcacgt 1679401 gaaaagaaga ctggcctgca aacgttaaga tggcaagctt gacaagtatt tccgacacat 1679461 ttacaatgaa gttgtaacat ttgttttttt aacatgattg ttaaaccatt taaacttgac 1679521 aagggcgatg aacacactca ttccctgtga aggttctgta tgttgagaaa actagacaat 1679581 gtacatgccg acacttttta agcaacaacc aagttcatag caagaggagg tgaaagtatg 1679641 accccaatta tgatggttct catctccatt ttgctgattc tactcggttt agttgttggc 1679701 tactttgttc gtaaaaccat tgccgaagcg aaaattgcgg gcgcacgcgg tgcagccgag 1679761 caaattcttg aagatgcgaa gcgtgatgct gaagcactga aaaaagaagc tctgcttgaa 1679821 gcaaaggatg aaatccacaa acttcgaata gatgctgaac aggaagttcg tgaaagacga 1679881 aatgagcttc aaaaacaaga aaaccgttta ctccaaaagg aggaaaacct tgatcgcaaa 1679941 catgagggaa ttgataaacg ggaagcgatg ttggagaaga aagatcattc tctgaatgaa 1680001 cgacaacaac atattgaaga gatggaaagc aaagtggatg agatgattcg tatgcagcag 1680061 tctgagttgg aacgaatttc gagtctgact cgtgacgaag cgaaacaaat cattcttgag 1680121 cgggttgaaa acgagctttc acatgacatc gccatcatga caaaagaaac tgaaaaccgt 1680181 gcgaaagaag aggcggataa gaaagcgaaa aacattcttt cactcgcctt acagcgctgc 1680241 gcagcggacc acgttgccga aacaacggta tcagttgtca atcttccaaa tgatgagatg 1680301 aaaggacgta tcatcggacg ggaagggcgt aacattcgta cgcttgaaac gctgacagga 1680361 attgacctga ttattgatga tacgcctgaa gctgtcattc tttccggatt tgatccgatc 1680421 agacgtgaga cagccagaat tgctcttgat aaactcgttc aggatggccg tattcatccg 1680481 gcacggattg aagaaatggt tgaaaaatct cgccgcgagg tcgatgacta tattcgtgag 1680541 atgggtgagc aaacgacatt tgaggttggc gttcatggcc tccacccaga tctcatcaag 1680601 atcctcggcc gcttaaagtt ccgtacaagc tacggtcaaa atgtgcttaa gcattccatg 1680661 gaagtcgcat tcttggccgg tctaatggca tcggagcttg gtgaagacgc aaagcttgct 1680721 aaacgtgcgg gtcttcttca cgacatcggg aaagcaattg accatgaagt agaaggaagc 1680781 cacgttgaga tcggggtaga gcttgcgacc aaatataaag agcacccagt cgtgattaac 1680841 agtattgcat cacaccacgg ggacgaggag ccgacttcca ttattgctgt actggtagct 1680901 gcagcagatg cgctttccgc tgcaagacct ggcgcaagaa gtgagacgct cgagaattat 1680961 attcgaagac ttgaaaaact tgaagaaatt tctgagtcct acgaaggtgt tgaaaaatca 1681021 tttgccattc aggctggacg cgaagtgcga attatggtga agccggattc aattaatgat 1681081 cttgaggctc atcgactggc gcgagatatc cgcaagcgaa ttgaggacga gctcgattat 1681141 ccaggtcata ttaaggtgac agtaatcaga gagactcgag ccgtagagta tgcaaaataa 1681201 agtgatgcgc taagcatcac tttatttttt tgacggcaag gaattttcaa gaagaaagga 1681261 tttacaaaat gagaatttta tttatcggag atgttgtcgg ttcaccgggc cgtgacatgg 1681321 tcaaagaata tgtaccaaag ctaaaaacaa aatataagcc tcactttacc attattaatg 1681381 gtgaaaacgc cgcacatgga aaaggcctga cggaaaaaat ttatcacagc ttaatccagt 1681441 ccggcgcaga tgcaatcaca atggggaacc acacatggga caaaaaagaa atatttgatt 1681501 ttatagatga cgttccgaac ttggttcgcc cggcaaactt tcctgaagga acaccgggga 1681561 aagggatcac atatgtgaaa gcaaacggca aagaactagc agtcattaat ttgcagggac 1681621 gtacgttttt gccgccgctt gatgacccgt ttttaaaagc ggatgaattg atcgcagaag 1681681 ctgcgaaaag aacaccgtac atttttattg actttcatgc cgaagcgaca agtgaaaagc 1681741 tcgcacttgg ctggtacacg gatggacggg catcggctgt agtaggaact catacacacg 1681801 tgcaaacagc ggataaccgc attttgccga agggaacggc atatattact gatgtgggaa 1681861 tgactggccc gtatgacggt atactgggga tggacagaga gacgattatt aagcgattca 1681921 aaacgaacct tccagtccgg tttactgtcg ctgaaggaaa aacaacgctc agcggagttg 1681981 tcattgacat tgacgatcaa acgaaaaaag ccgtgaaaat tgagcgtatt ttaatcaacg 1682041 atgatcacat gttctttgaa tagttgaaca tatggttatt ttataaaaat attaaaaaga 1682101 aaagcaggaa tatagcaact ccttagtgaa tatagtaaaa atggaaggta gcccgctatt 1682161 tttgaaaagc attgtgggga tggctttttg gatagcaaca tctaataatg attgttctaa 1682221 tgaacactca cttatccatt gtaaaactaa gggggagcag aaatggaaat cttaaaagtt 1682281 tcagcaaaat cgagtccaaa ttcagtggca ggtgcgcttg caggcgtgtt gagagagcga 1682341 ggagccgccg agattcaagc gatcggagcg ggtgcattaa accaggctgt aaaagctgtg 1682401 gcgattgcca ggggatttgt ggcgccaagc ggcgttgatt tgatttgtat tccggctttt 1682461 acagatattc aaatcgatgg ggaagaaaga acagcgatta aattaatcgt ggagcctcgc 1682521 taaaaacaaa taaagcattc tcaacctgtt tgcgtaatgc aaacaggttg tttttcattt 1682581 attgtgatat tttctcccga tagtattttt agcacataaa tgagcgaata tacaaaatca 1682641 gaaatgagct aaaacgtttc aaaaaaaatt tccgcccatt tttcaagaca gatacttttg 1682701 tccttctgga aaagacagtt ctgtttacgc ttattccata tcatggtaca atccgaatat 1682761 aacaagaatt tttcaaggag gattgtacat gcagagtgga aagatgaaag ctctaatgaa 1682821 aaaggacggg gcgttcggtg ctgtgctgac tgaagttccc attcctgaga ttgataaaca 1682881 tgaagtcctc ataaaagtga aagccgcttc catatgcggc acggatgtcc acatttataa 1682941 ttgggatcaa tgggcacgtc agagaatcaa aacaccctat gttttcggcc atgagttcag 1683001 cggcatcgta gagggcgtgg gagagaatgt cagcagtgta aaagtgggag agtatgtgtc 1683061 tgcggaaaca cacattgtct gtggtgaatg tgtcccttgc ctaacaggaa aatctcatgt 1683121 gtgtaccaat actgctataa tcggagtgga cacggcaggc tgttttgcgg agtatgtaaa 1683181 agttccagct gataacattt ggagaaatcc cgctgatatg gacccgtcga ttgcttccat 1683241 tcaagagcct ttaggaaatg cagttcatac cgtactcgag agccagcctg caggaggaac 1683301 gactgcagtc attggatgcg gaccgattgg tcttatggct gttgcggttg caaaagcagc 1683361 aggagcttct caggtgatag cgattgataa gaatgaatac aggctgaggc ttgcaaaaca 1683421 aatgggagcg acttgtactg tttctattga aaaagaagac ccgctcaaaa ttgtaagcgc 1683481 tttaacgagt ggagaaggag cagatcttgt ttgtgagatg tcgggccatc cctcagcgat 1683541 tgcccaaggt cttgcgatgg ctgcgaatgg cggaagattt catattctca gcttgccgga 1683601 acatccggtg acaattgatt tgacgaataa agtggtattt aaagggctta ccatccaagg 1683661 aatcacagga agaaaaatgt tttcaacatg gcgccaggtg tctcagttga tcagttcaaa 1683721 catgatcgat cttgcacctg ttattaccca tcagtttcca ttagaggagt ttgaaaaagg 1683781 tttcgaactg atgagaagcg ggcagtgcgg aaaagtaatt ttaattccat aaagggggat 1683841 aaacatgacg aaggaatttg agtttttaaa agcagagctt aatagtatga aagaaaacca 1683901 tacatggcaa gacataaaac agcttgaatc tatgcagggc ccatctgtca cagtgaatca 1683961 ccaaaaagtc attcagctat cttctaataa ttacctcgga ttcacttcac atcctagact 1684021 catcaacgcc gcacaggagg ccgttcagca gtatggagcc ggcaccggat cagtgagaac 1684081 gattgcgggt acatttacaa tgcatcaaga gcttgagaaa aagctggcag cctttaaaaa 1684141 aacggaggcg gcacttgtat tccaatcagg cttcacaaca aaccaaggcg tactttcaag 1684201 tattctatca aaagaggaca ttgtcatctc agatgaattg aaccatgcct ctattattga 1684261 cggaattcga ctgacaaagg cggataaaaa ggtgtatcag cacgtcaata tgagtgattt 1684321 agagcgggtg ctgagaaagt caatgaatta tcggatgcgt ctgattgtga cagacggcgt 1684381 attttccatg gatggcaaca tagctcctct gcctgatatt gtagagctcg ctgagaaata 1684441 tgacgcattt gtgatggtgg atgacgccca tgcatccgga gtacttggcg aaaacggcag 1684501 gggaacggtg aatcacttcg gtcttgacgg cagagtgcat attcaggtcg gaacattaag 1684561 caaggcaatc ggagtgctcg gcggctacgc tgcaggttca aaggtgctga tcgattattt 1684621 gcgccataaa ggccgtccat ttttattcag cacatctcat ccgccggcag tcactgcagc 1684681 ttgtatggaa gcgattgatg tcttgcttga agagccggag catatggagc gcttgtggga 1684741 gaatactgcc tattttaaag caatgcttgt gaaaatgggt ctgactctca cgaagagtga 1684801 aacgccgatt cttcctattt taataggtga tgaaggtgtg gcaaagcaat tttcagatca 1684861 gctcctttct cgcggtgttt ttgcccaaag tatcgttttc ccgactgtag caaagggaaa 1684921 agccagaatt cgcacgatta taacagcaga gcacaccaaa gatgaactgg atcaggcgct 1684981 tgatgtcatc gaaaagacgg caaaggagct ccagctattg taacaagagg aagagtttac 1685041 tcttcctctt ttgattcctt attgattatt attctcaatg agtgtacaat gataggttgc 1685101 cagttgtgca gagcttcaat aacctttata ctgaagggtg gaagtttggt ttgaaaggag 1685161 aaaatatgac atgaatgaaa aacaaaaatt agagagcgga caagttcatc catcggacaa 1685221 aaaatccgag aaggattaca gcaagtactt tgaagctgtt tacattccgc cttctttaaa 1685281 agacgcgaaa aaacgaggca aggaagccgt tacttatcat aatgacttta aaatttctga 1685341 acaatttaaa ggattgggag acggaagaaa gttctatatc cgtacgtacg gctgccaaat 1685401 gaatgaacac gatacagagg ttatggcagg gatctttatg gcgctcggtt acgaagcgac 1685461 aaactctgtt gacgatgcca atgtcatttt gttaaataca tgtgcaatcc gtgaaaatgc 1685521 tgaaaacaag gtgtttggtg agctcgggca cttaaaagca ctgaaaaaaa acaatcccga 1685581 tctgatttta ggcgtgtgcg gctgtatgtc ccaagaggaa tcagtcgtga accgtatttt 1685641 gaaaaaacat ccgtttgtcg atatgatttt cggaacgcat aacattcatc gcctgccgga 1685701 gcttttgtca gaagcatacc tttcaaaaga aatggttgta gaagtttggt ctaaggaagg 1685761 ggacgttatt gaaaaccttc caaaagtccg aaatggaaaa attaagggct gggtcaatat 1685821 catgtacggc tgtgacaaat tctgtacgta ttgcattgtg ccttacacac gcggaaaaga 1685881 aagaagccgc cgccctgagg atatcattca ggaagtgaga aggctcgcaa gtgaaggcta 1685941 taaggaaatt actctgttag gccaaaacgt aaacgcgtat ggaaaagact ttgaagatat 1686001 gacgtacgga cttggtgatt tgatggatga actgagaaaa atcgatatcc cgagaatccg 1686061 ttttacaacg agtcatccgc gcgactttga cgaccgcctc attgaagtgc tggcaaaagg 1686121 cggaaatctg cttgatcaca ttcatcttcc ggttcaatca ggaagctcag aagttctcaa 1686181 gctgatggcc cgcaaatatg acagagagcg ttacatggag ctggtgcgaa aaattaaaga 1686241 agcaatgcca aacgcttctt tgacaacgga cattatcgtc ggatttccaa atgaaacgga 1686301 cgaacagttt gaagaaacgc tttctctata ccgtgaagtg gagtttgaca gcgcctatac 1686361 gttcatttac tctccgcgtg aaggcactcc ggctgctaag atgaaagata atgtaccgat 1686421 gcgtgtgaaa aaagaacgcc tgcagcgtct aaacgcactg gtgaatgaaa tttctgctaa 1686481 aaaaatgaag gaatacgaag gcaaggttgt cgaagtatta gttgagggtg aaagcaaaaa 1686541 taaccctgat attcttgctg gctatactga aaaaagcaag cttgtcaatt tcaaagggcc 1686601 gaaggaagcc atcggcaaaa tcgtccgcgt gaaaatccag caagcgaaaa catggtcgct 1686661 tgacggagaa atggtaggag aagcaatcga ggtgaaatga gatgacgctc tactcaaaaa 1686721 aagacattgt gcagcaggct cgaaaccttg caaaaatgat ttctgaaaca gaagaggttg 1686781 attttttcaa acgggctgaa gcgcaaatca atgagaatga caaagtgtcc acaatcgtta 1686841 atcagattaa agccctgcaa aagcaggctg tcaatctgaa gcattatgaa aagcatgaag 1686901 cgctcaaaca agtagaagca aaaattgacg cgctgcaaga agagcttgaa gagattcctg 1686961 ttatccagga attcagagac tcgcaaatgg aagtaaatga cctactgcag ctcgttgcac 1687021 acaccatttc caaccaagtc acaaatgaaa tcatcacatc aaccggaggc gacctgctga 1687081 aaggggaaac cggttcaaag gtgaagcatt caaataacag ctgttctctc taaacacggt 1687141 gcctttacag gcccgtgttt ttttatcatt tgtgcggtta aaaatgaact aaataatcta 1687201 tgtaccaaat gttcaattgg tttttctgtg ctcagccgcg tataaacttt atcgcactta 1687261 taagtaaagt ttctaggcac ccctgcatac aatggaacag aaactttgta tttttatatt 1687321 ttatttataa aaatgcacac tagacaaatg cccagcataa gataacacga agaagaacaa 1687381 ggaggcatgc cggaatgtct gaatacaggg aaattattac gaaggcagta gtagcgaaag 1687441 gccgaaaatt cacccaatgc accaacacca tctcgcctga gaaaaaaccg agcagcattt 1687501 tgggtggttg gattattaac cacaagtatg acgctgaaaa aattggaaaa acggtagaaa 1687561 ttgaagggta ttatgatata aacgtatggt actcttacgc ggacaacaca aagacagagg 1687621 ttgtcacaga acgggtaaaa tatgtagatg tcattaaact cagatacaga gacaataatt 1687681 acttagatga tgagcatgaa gtgattgcca aagtgcttca gcagccaaac tgccttgaag 1687741 tgaccatttc gccgaatgga aataaaatcg ttgtgcaggc agaaagagaa tttttggcgg 1687801 aagtggtagg ggaaacaaag gtagttgttg aggtcaatcc tgactgggaa gaggatgacg 1687861 aggaagattg ggaagatgag cttgatgaag agcttgaaga catcaacccg gagtttttag 1687921 tgggagatcc tgaagaataa aaaagggact aggggagaca gtacccccaa gtctcttttt 1687981 tatattgata tatcattctt ttatcacttt ttgtttatgt tataatgaag gttggaaaat 1688041 agaaacgttg atacatagtg agggattaaa caatggccgg ttatacgcct atgatacagc 1688101 aatatttaaa aataaaggca gagcaccagg atgccttttt attttttcgc ctgggtgatt 1688161 tttatgaaat gttttttgag gacgccaaaa aagcgtcaca agagctggaa attacgttaa 1688221 cgagcagaga cggcggtgcg gctgaaaaaa taccgatgtg cggtgtgccg tatcattctg 1688281 cttccgcgta tatcgaacag cttattaaaa aaggatacaa agtggcgatc tgtgaacaga 1688341 cggaagatcc gaaagccgca aagggcgttg tgaaaagaga agtagttcag ctgattacgc 1688401 ccggaactgt aatggacggc aaaggcatcc atgagtcgga aaataatttt atcgcatctg 1688461 tttcagcctg ctcgaacgga tacggacttg ctctgtctga tttaacaacg ggagaaaatt 1688521 tggctgtttt gattgaacgg cttgaagacg tcatatcaga aatttattca gtcggcgcac 1688581 gggaaatcgt ggtttcagga agcttggatg ccgatacagt ggcacagctg agagagcggt 1688641 gcggtgcaac gatttcaatt gaagacggag aaacagacga acacgtaacg atcattgagc 1688701 acttaaataa tgaagatata acaaaaacat ttctgcgctt atatacgtat ttgaaaagaa 1688761 cccaaaagcg cagccttgat catcttcagc ccgtgcaggt gtatgagctt gaggaagcga 1688821 tgaaaattga cttgtactca aagcgtaatc tggagctgac cgaaacgatt cgttcgaaaa 1688881 ataaaaaagg ctcccttttg tggctgctgg atgaaacaaa aacggcaatg ggaggccggc 1688941 tacttaaaca gtggattgac cggccgctta tcagagtcaa tcaaatcgaa gagcgccaag 1689001 aaatggtgga aacattaatg tcccatttct ttgaacggga agatctgcgt gaacgtttaa 1689061 aagaagtata tgacttagaa cgccttgccg gccgcgttgc attcggaaat gtcaatgccc 1689121 gggatttgat tcagctgaag gaatcgttaa agcaagtgcc tggcatcaaa cagctggttg 1689181 cttcactggc tcatgacaag gccaaggaac gtgcaaagcg cattgaccct tgcggggatg 1689241 tacttgaact gctggaagaa gcgctgtacg aaaaccctcc tttatcggta aaagaaggga 1689301 acctgattaa agatggttat aatcaaaagc ttgatgaata tcgtgatgca agcagaaacg 1689361 gaaaagactg gattgcccgc ctggaacagc aggagcggga atacacaggc attcgctctt 1689421 taaaggtcgg ctttaataaa gttttcggtt attacattga agtgacaaaa gcaaacttgc 1689481 atttgcttga ggaagggcgt tatgagcgga agcagacgtt aaccaatgca gagcgctaca 1689541 ttacacctga attaaaagaa aaagaagcgc tcattttaga ggcggaaaat aacatctgtg 1689601 agctggagta cgagctgttt accgagctgc gcgagaaagt gaagcagtat attccgcggc 1689661 tgcagcagct tgcaaaacag atgagcgagc tggacgcact gcaatgcttt gcgacaatca 1689721 gtgaaaatcg ccactacacg aaaccagagt tctctaaaga tgaagtcgaa gtgattgaag 1689781 gcagacaccc ggttgttgaa aaagtcatgg acagccagga atatgtcccg aacaactgta 1689841 tgatgggcga taacagacaa atgcttctca ttacaggtcc aaacatgtca gggaaaagca 1689901 cgtatatgag acaaatcgcg ctcatttcca ttatggcgca aatcggctgc tttgtacccg 1689961 cgaaaaaagc ggtgctcccg attttcgatc aaatttttac gcgaatcggc gctgcagatg 1690021 atttgatttc cggacaaagt acatttatgg tagaaatgct tgaagcgaaa aatgcgattg 1690081 tcaatgcgac gaaaaacagc ctcattctgt ttgatgaaat cgggcgggga acgtccactt 1690141 atgacggcat ggcgctggca caggcgatta ttgaatatgt tcacgatcat atcggcgcca 1690201 agacgctgtt cagcacacac tatcacgagc tgaccgttct tgaggacaag ctgccccagc 1690261 tgaaaaacgt tcatgttcgc gctgaagaat ataacggaac ggttgtcttt cttcatcaaa 1690321 ttaaagaagg tgcggctgat aaaagctatg gtatccatgt agctcagctt gccgaactgc 1690381 cgggagatct gattgcgcgc gctcaagata ttttaaaaga gcttgagcat tcaggaaaca 1690441 aaccggaagt gccggtgcag aaacctcagg tgaaagaaga gccggcacag ctgtcctttt 1690501 ttgacgaagc ggaaaagccg gctgaaacac caaagctttc aaaaaaagaa aagcaagtga 1690561 tcgatgcttt caaatcactt aatatactgg atatgacacc gcttgaagcg atgaatgaaa 1690621 tgtacaagct gcaaaagaaa ttacattaaa acggggtgat gaatgtggca aaagtcatcc 1690681 aactgtcaga tgagctttca aataaaatag cggcgggcga ggttgtggaa cggcccgcct 1690741 cagtcgtcaa agaattggtg gaaaatgcga tcgacgctga cagcacagtc attgaaatcg 1690801 atattgagga agcaggcctt gcatccattc gggtcttgga taacggcgaa ggaatggaga 1690861 atgaagattg caagcgagct ttccggcgcc acgcaacgag taaaataaaa gatgaaaatg 1690921 atttattcag ggtgagaacg ctcggtttca ggggagaagc cctgccgagt atcgcgtcag 1690981 tctctcatct ggagattaca acaagcactg gtgaaggagc tgggacgaag ctcgtcctcc 1691041 aaggaggaaa catcatttcc gaatcgcgtt cctcaagcag gaagggaact gaaattgtcg 1691101 tttccaacct gttttttaac acaccggccc gtttgaaata tatgaaaacc gttcatacag 1691161 agcttggaaa cattacagat gtggttaacc gtattgctct ggcgcatcca gaggtatcga 1691221 tccgcctgcg ccatcatggg aaaaacctgc ttcaaacgaa cggaaacgga gatgtgcgcc 1691281 atgtactggc agcgatttac ggcacggctg tcgccaaaaa aatgcttccg ctgcatgtga 1691341 gctccttgga ttttgaagta aagggatata tcgccctccc agagattaca cgggcgtcga 1691401 gaaactatat gtcgtctgtg gtcaatggcc gttacattaa aaatttcccg ctcgtcaaag 1691461 cggttcatga aggctatcat acgcttctgc cgatcggacg ccatccgatt acttttatag 1691521 aaattacgat ggacccgatt ttagtcgatg tcaacgtgca tccatcgaag cttgaggtcc 1691581 ggctcagcaa ggaaacagag cttcatgact taatacgtga cggaattaaa gatgtgttta 1691641 aacagcagca gctgattcct agtgcccagg tcccgaaaaa atcagcacct gccatcaaaa 1691701 atgagcagca gtttataacc tttgatgaaa agcctccgga aaaaaaagtt ccggaaaaat 1691761 cgactgcgcc atcttattca ccgatgaagc tcagctcagt cgtaaaagag ccggttgatg 1691821 cggaggaaaa attgccccct ctccaatttg atgctcctcc tatcgttgat caggaacaaa 1691881 cccttgaggt gtccgatgtt tcagcagaac agcctgaaac atttgagcag gaatgccatg 1691941 aggaacagcc gcagccagcg tctgatcggg ttccaattat gtacccgatt ggccagatgc 1692001 acgggactta tatattggca caaaacgaaa acggcctata tattatcgac cagcacgccg 1692061 cccaagaacg tattaaatat gagtacttcc gtgaaaaggt gggggaggtt gagcctgagg 1692121 tgcaggagat gattgtaccg ctgacgttcc actactccac aaatgaggct ttgattattg 1692181 aacagcacaa acaagagctc gaaagcgtcg gtgtcttttt agagtcattc ggctctaaca 1692241 gttacatcgt ccgctgccac ccagcctggt ttccaaaggg agaagaagca gagcttatag 1692301 aagaaatcat tcagcaggtg ctcgactcca aaaatataga tattaaaaaa cttcgcgagg 1692361 aagcggcgat tatgatgagc tgcaaaggct ccatcaaagc aaatcgccac ctcagaaacg 1692421 acgaaatcaa agcgcttctg gacgacctcc gaagcacatc agacccattt acatgcccgc 1692481 acggccgccc gatcatcatt caccactcga catatgagat ggaaaagatg ttcaaacgcg 1692541 tgatgtagcg ggggtggtag gcattgatcc attctctgaa tggatcaatg ctttttttgt 1692601 actccttcga gtgtcagatt ataagaaacg gttgtaaacg tgtgagcagt gttaacgcat 1692661 tatacttcat ggttcctccg tataacaaaa tttccattta caggcaattg ggattaatgt 1692721 atattttggg tgagggggtg gaaacatatg gcatgtggtc cgaagatcat tatctttttg 1692781 gatgaacttg atgatccaaa tgtgagaatc attttagaat gcagaattta aattacaaca 1692841 ttgtgttttg ctccctgttc gtgtgaacag ggagattttt tcgtttatat aactggtgat 1692901 gtccaaatat agggtgttat gaattttcca tatctgccat cggctttaag ctgcttctct 1692961 attaggctgg ttatcaaaag caagttcaat gatagccatg aaagctgata tcacaacaag 1693021 caagacatct ggaatataaa tagactgcat aaagtaatct gcaaaacaga tcgttataag 1693081 attgctgata aaatacagta taaaagcaaa aagtgcagtc tttttcaatg aaagtgattt 1693141 tgccaaaatg atagagataa tctttgtgag tgggtctatg attaaaccta cagcaaagca 1693201 ggctaaaata aataaagcta atgtttgatt ggaagcgtat gtgatgccaa gtatggagaa 1693261 taagcctttc atcccgaaga aaaagccgcc gaagatgact gcaagcgcga tggccgcgat 1693321 aaaagtaata gatacaattc cgattaattt tgatctcagg ttaaaatctt tagagtgctc 1693381 gttctgttct ttttggttca tgtatgacac tcccttcacc tgcttactca tacaaacagc 1693441 acccttgaat cagcccaaaa tatctataag tctgttttct gacgaaaata gtatagcata 1693501 ttttaacaaa accaaaaaag gccctttcca ctggggaagg gcctttttca tcatgttaac 1693561 tcctgagatt cgccgaagct ttctcttttt ttggccaaat aaaatagctg gctgtaatga 1693621 gaaagtcaat gcctataatg acagtccaca gtttaagaat gccgctcaac gcctcggttc 1693681 gggaagagtc attgataaaa tagatcatcc ctgccaatag tcccgcacca attaagtagg 1693741 ccagcacatg tcttagccag cctttcgcac cgtgcttggc atggtccatt ccaaaacgtt 1693801 tcagcggttt tgttcctttt tttgtcacat aatattgaaa cttttcatct gcccattgaa 1693861 tcatttgttt cccataagcg atcgatatac cgatgtaaac agctgcaatc ccatgggctg 1693921 cggtcgctga ggctccgcgg taaaggtcca caccagttgc cgctaacaag atcaaatcga 1693981 taactggagt taaggcaagg aatagcagtc ctaatgtatg tcgtttgaat acgtagcgta 1694041 cagcaagccc caaaacaatg acaacccaaa acgcaatttc acagaaaaca atcatccatg 1694101 cgataccgtt caatccattc ccctcttttc aatacagttg tattatttaa ataatatgtt 1694161 accatctttg tttttgtaac acaactgtat tataaaaatt gccccgcctt tgaacgaaag 1694221 ctcaaaggcg ctacgctgta ttattttgat gaaagtggct gtcagctgtg ctggatatca 1694281 attgtatata ctgcacgatc tgttacgacc ttcaatcctt cgttttcttg gtgaatatga 1694341 agctcaccta ataaaggaat ctcataggca ttttgcggaa gcggtacgtt tccgtcctca 1694401 gtgaatgttg ttccttcgcc ttctaaaaca agctcttctt tcgcaacata atcatcagga 1694461 tgattcgtac tgcgtatagc cactttttga aggtggagaa caatctgatc caagtctgat 1694521 atctcttcat catgggtcaa ttcacctttt ctaatatcaa gcgtctggcc gacttttgat 1694581 tccagccatt gagaaagctg tgtattcgtg tgtgccatca atattcctcc ttttgatcta 1694641 cacgatacta ttcccaattg ctgcatcttt tacacgggaa agagccgccc cactctttat 1694701 gtatgaaaca gttcgctgtt gagtgccttg atatagcgta cggcagaacg ctggaccgat 1694761 tcgtcggcat tttctttgac aactttagag aaagcattgt aaagccggtt gaattgaagc 1694821 ggttttactt tggctgctat ttcttcaact ttggaggcgg gaaggggaat gagatttggg 1694881 tagctgtaca taaagctgac ccagtttcga tccgccgcaa ccgtaatgat atctccggtc 1694941 aatagacagc ctttcccttc attgcccttg ctccaatgca aaacagcacc gcctttaaaa 1695001 tgtccgccca gtcggtaaag gtccagtccc ggcttcatat tgagcgtttc ccctgaccag 1695061 aagtgaatgt gattgcttgg ccttgtcacc cattctttat catcctcatg gatatagatc 1695121 ggcgcctgaa acgcttcagc ccactcaacc tgagtagagt aataatgtgg atgagacaag 1695181 gcgatggctt gaataccgcc taattcgttg atttggtcaa ttgtcttttg gtcaagatat 1695241 gtcatgcaat cccacagcac attgaagccc ttatgctgaa taagatgggc tgtttgtcca 1695301 atcgcaaact ctggttcagt tttgatgctg taaagatgct cttcttcctt tttaaggatg 1695361 ttttgaaggt ttcctttctc acgcatgtct tcaagggttg tccaagtttg tccatcggga 1695421 tgaatatact gtctttcatc ctcgcaaatc agacacgagt tgggcggatc tacagtctgt 1695481 gcatgttgca caccgcatgt attgcagata taatatggca ctttcttcac ttccttcatc 1695541 tattttccat tattttacct tatgattatg aatattcaaa cgaaaaaacc ggcagttctg 1695601 ctgagagaga attgccggct tttgatgatg tttattggcc gggaacggaa ttttctgcgt 1695661 tgacagcgcc cgctccgtag atattcggat cttcatcttt ccatttgtcc gtgccgtttt 1695721 tcaaaagctc ttttacttca tcaggggtaa gatccgggtt ttgctgaaga attaaagctg 1695781 cgattcctgc gcaaatcggt gttgccatcg aggttcctga cattgtaaag tactgagacc 1695841 ctacacggct tgacttttgg agcttatcaa tataagaatt cggagagcga agggaaataa 1695901 tattaacacc cggcgctaaa atatcgggct tttctttccc gtatactgtc gggccgcggc 1695961 ttgagaagga agcgacagta tcatcatcgc tgcttgcagt attgttatcg tcaagcgcac 1696021 ctactgtaat caccttttcg ctcacgcccg ggcttgcaat ggtctgcgaa tcagggcctg 1696081 agtttccggc agcgacacag acgacaatcc ctgcgctcca cgcttcctca accgctctga 1696141 ctaacggatc ttcctgttca tgatcatatc taagggcatc gcccccgagc gacatgctca 1696201 taatatcaat cggttcatcg gggttgtcct cattgtattg aatacaccac tcaacaccct 1696261 ctataatatc tgctaacgtt cctgaaccct gcttgtttaa tacctttacg ccgatgagat 1696321 tggcttccgg tgcaggtccg cggtattgac cggaagagga tgcaccgctg cttgcgacat 1696381 cacctgcaca gtgtgtgcca tgaccattat catcgtacgg ctctgttttt tgattgacca 1696441 tgtccgcgaa tccgataatt cttccttcta gatcaggatg cgggtagatt cctgtatcga 1696501 caacagcgac agtaacacct tttcctgtca gggtttgccc gtttctgacg acttccttcg 1696561 catggcttgc ttcggttgcc gtgtctaaaa gcgctttgac ttcgcggttt aaatacactt 1696621 tacggatatt gctgcattca gagagaaggg aatgtaatgc tgaaggagta acctcggcgc 1696681 tgcagcagtt gattttgttg aagcggcttt ttagcttgct gcgtttttct ttttgcagca 1696741 cctctccagc catttgaaag ccggtctcgt gacagccttc ctcaaattcg ataatgactg 1696801 acattttttt tctgttttgc aatttggttt cgaaaaattt atgcaagaag caaggagtcc 1696861 atttgaaggg cttgtaaagt tgcaatacgg tttcccgtaa cggccaatct agcttgtgag 1696921 catttgctct caccatttgt accatagagt acccaaacat gtattttcct cctattataa 1696981 ggttctctgt atactctatg aacagatgat aggtttggta agtttgtttg tcctctgtaa 1697041 gagacagaca agagtttgtt tttctgaatc tttcgcatta gatacgatag attcagaagc 1697101 tgaggaaatc attggggatt gaaaaagaac gtttgttcgt attataatgt gatcatatca 1697161 aactgggaag gggagagcaa ccgtatgaat ttctacttgc accgatcttt ggaaagccaa 1697221 atgccaatca gcattatata tgaagaaaga cggaacgatt agtaaaagaa cgattattgt 1697281 gagacagaaa agcaaaacga aaatcaaagc attttgtttt tcgaaacaac agatcagaac 1697341 atttttattg gactctatcc tctcctgtga ttttgtgaga acaaataagc aaaatctcta 1697401 ttctgcaggc cggtaacagc tgtccgtctc agcaaccggg cagcctgtta ctaaaaccct 1697461 ccttaaacct atatacattt atttgccaag tgaggttgtt cctacctttt ttgtctttcc 1697521 tctcaacctt ttttcactct tatttgaaat gaaccgctaa taaccgtgac aatcaattga 1697581 ttttttgaaa ccgggaactt tttcactgat gatattgtgt atacaatggt aagataaaac 1697641 ctattggcta aacctcatat aatgaaccgc gccattctta tgaaaggagt taaacatgag 1697701 aagattttta ctaaatgtca tattagtctt agccattgtc ttgttcttga gatatgttca 1697761 ttactcattg gaaccagaac catcaaatca gccagataca tattcaaatt tcagcagctt 1697821 ggcagagaat gagagcccag ccgattacga tatttcatat aatgagaaaa aaggaagcaa 1697881 agtcttaatt atgtctccgc atggcggaag aattgaaggc ggagtaagtg agcttgtgcg 1697941 ttatttcaat aatgaatact ctacatacct atttgaaggg ttgaagtccc atgataacca 1698001 aacactgcac attacaagca ccaactttga tgagccattg gcaaaaaaga aaatcaagga 1698061 gcatcaatat gtggtggctt ttcacggata taaaggagag aacaagaata cccttgtagg 1698121 gggaacagac cgaaagcggg cgaaaatgat tgtgagagcc cttgagcgga gagggttttc 1698181 cgctgagtta gcgtcgtcta aaagcggtct tgctggattg aatgccgaaa acattaataa 1698241 ccaaggggaa acggggctaa gtatccagct ggaaatcagc cgtgagcaga gagaagcatt 1698301 ttttgatgat ttttattata aaaatagaaa atacacaaag aacagtgaat tttatgctta 1698361 tgtcagtgcg atcaaaggtg tcctggaaaa agagtattcg taacaagcag atcagaagac 1698421 aaaataagag aagatcagta gactgaaata ggataaaaaa ggaggcaaaa caatggcaga 1698481 tcatcatttt tatttaaaag cgaactggcc gggtaaccgt aatgatgtcg gtacgatcga 1698541 aagcggaaac ctgatcacat cgatttccat tcctaaagaa atggatggcc cgggagaagg 1698601 gaccaaccca gatgaaatgc ttctcggggc ggcagcgacc tgttacatta ttacacttgc 1698661 agcgatgatg gagagaagcg ggctggaaaa agaagactta cagatggagt cagaaggcat 1698721 tgtcaacgtt acaaaaggag tctttacata caaaaagatc attcaccgtc cctctgtcgt 1698781 gcttaaacat gatgcttcac aagacgacgt cgcattggcg cacaaacttt gtaaaaaagc 1698841 ggagtcgtca tgcatgattt cgcgtgcaat tcaaggaaat gtcgagctgc agcttgaagc 1698901 ctctgtgaaa ctgggtggag aataaagaaa acagacggtc actcacaggc cgtctgtttt 1698961 ttatcttcag cgtgggcttt cgattgattt agcacgacca cgcctgcaat gacaagcgtg 1699021 agaccgaata caccttttaa actgatggtt tcgccaaaaa gcaaaaaccc gacaattgct 1699081 gtaagcgcgg taccaacgcc cgaccatgtt gcatacgcgc ttgataagtc aattgttttt 1699141 aaagaaaagc ttagaaacgt aaaagcagaa agaaatccga ctatgactcc ggcaatgggc 1699201 caggcttgtg taaatccttc tgaaagcttc aacatcgtgc tcccaaacac ttcagataca 1699261 atggcgagag ccaaataaag caatcctctc atcttcatca ctcctttacg gccaattaag 1699321 taacacgacc cctgatagta ataaaagaat cccgataagc cctttggcat tcagatcttc 1699381 cttgaaccat tttactccga tcactgtcgt cagcaccgtg cctgccccgc tccaagtcgc 1699441 ataggagagg ctcaggggaa tatggtttaa agtcagggac agcatataaa aggcgaggga 1699501 atagccaata acgaccaaag cacttggctt ccactttttg aagccatcag atactttcag 1699561 catggctgct cctatcgatt ccgaacatat ggcaatcgtg aggaatatat atcctatcaa 1699621 catcatgaat tctcctcact atatttttag attagaaaaa aaacttcagc tagaaaaata 1699681 ttagtgtatg cctatgtatg agtcaagaga ttcattttca cacacttaaa aagacccctt 1699741 tttaaggggt cttttgcgtt taataataaa aagggaacgg ggcatacgga taataggggt 1699801 atccgccata caaataagga ttaaataaag cgcttcctat aagcccgcct gcaaggccgc 1699861 cgataaacgg tcctccaaaa aatccgaatg gccggccaaa cccataacca aatccgggtc 1699921 ttccaaaccc gtaaccgaac ccgaacggtc ttccaaaccc aaatggtctc ccgaatccga 1699981 acggccttcc aaatattctt gtatcttcag ggctgaaatg ctctaactcg ttcatgtttt 1700041 ctttcctcct gtaataaagt gtagatgatg cagtgtattc accctgcccg gatttgattg 1700101 ggcgaatcga ggaaaaggag gatgtgaaca cattgggcct gtatcagtct gactggtcaa 1700161 aagcaccgcc ccacgcacat gcttatcatg tcaaaacaac gagagaacag ggccattatc 1700221 atctcatcga agggtttact cagccggcaa acggatcaaa taccgatcag catacacatt 1700281 actatacagg gatcacttca tttgaaaacg gccattttca tcggtattac ggaatctcag 1700341 gaccggcgat tcccttagca gatggcacac attatcatga aatcgaagaa acgacgtatc 1700401 tggcctataa cgagccgatt gagatccagt acggaggggt tgtgtacgat cccggagatg 1700461 acagaagaaa aacgcatcgt cataccctga aaggaaagac aagggaaatt gtcggcaatg 1700521 agccgctcgg ctggtagaag gatgtttacc gatgcaaaaa aagggcaaaa tggataggtg 1700581 gttgtccatg ttgaatgcta taatgggggg agatttataa aagagagtga tacatattga 1700641 ataatacgaa gcagcccgtt gtcattttag tcggaccgac ggcagtgggg aaaaccaatt 1700701 taagtattca gctagccaaa tccttaaacg cggaaattat cagcggagat tcgatgcaga 1700761 tttataaagg gatggatatt ggaacagcta aaattaccga acaggagatg gagggagtgc 1700821 cccatcatct gattgacatt ttagatcccc aagactcttt ctctactgcc gattatcaaa 1700881 gcttagtaag aaataaaatc agcgagattg caaatagagg aaagcttccg atgattgtcg 1700941 gcggtacagg gctttatata caatctgtgc tttacgatta tacatttacg gaagaggcaa 1701001 atgatcccgt gtttcgagag agcatgcaaa tggctgctga gcgggaaggc gctgactttc 1701061 ttcatgccaa acttgctgca gcagatcccg aggcagcagc tgcgattcat ccgaataata 1701121 caagaagagt cattcgcgca ctggaaattt tacatacgtc cggaaaaacg atgtcccagc 1701181 atttgaagga acaaaaacga gaacttctgt acaatgcagt gttaattggc ctgacaatgg 1701241 atagagacac gctttacgaa agaattaatc agcgggtcga tttgatgatg cagtcaggcc 1701301 ttcttccgga agtgaaacgc ttatacgaca agaacgtgag agactgtcaa tcaatacagg 1701361 cgataggcta taaagagctg tatgcatatt ttgacggttt tgtgacactt tccgatgctg 1701421 tcgaacagct aaagcagaac tcgaggcggt atgcgaaacg ccagctgacg tggtttcgca 1701481 acaaaatgca ggtcacatgg ttcgatatga caccgcctgt tgatatggag ctgaaaaaaa 1701541 aggaaatttt cacacatata gcaggaaaac tcgaacttta atcgaaactg tatgatatag 1701601 agaatcaagg aggacgaaac atgaaaccga ttaatattca ggatcagttt ttgaatcaaa 1701661 tccggaaaga aaatacgtat gtcactgttt ttttgctgaa cggctttcag ttgcggggcc 1701721 aggtgaaagg ctttgataac tttaccgtat tgttggaatc ggaaggtaag cagcagctta 1701781 tatataaaca tgcgatctca acgtttgcgc cgcaaaaaaa cgtccagctt gaactcgaat 1701841 agatcaaaaa atgccatgtc aagacatgag gaaaggctgt cgggggttcc cggcggccat 1701901 ttttaacatg aatccacttt tgctccaagc tttttgtgta agctgaccat gccaaggcac 1701961 ggtctttttt tatgagaaca acatacggaa gtaaaaatgg tatattatgt ataaaatgaa 1702021 tttgggagtg atcgatcttg tttgaaagtg aagcagaact gagacgaatc aggattgcac 1702081 ttgtatggat agctgtcttt ttactgttcg gggcgtgcgg gaatcaagat accattattg 1702141 aaacagacaa cggcaattca gactatgaaa cgcctcagcc cacctcgttt ccacttgaac 1702201 ataaccattt tggcgttatg gaggacggct atatcaaaat ttatgagtat aatgagtccc 1702261 gcaatgaggt aaagctgaag aaagaatacg cggatgatga gcttgaataa aattcacaag 1702321 cattcgaatt tacaaagcgg atgccagccg ctaaactaaa tacagacaca gatcaaacag 1702381 agggtgaaaa catgaagcat aaagtgatcg tgaatcattg ggaagaaatt tgcgaagatg 1702441 attcttgcta tgaatacgga acaagtatca ttgtgaacgg aaaagaatta atcagagaag 1702501 cgtcaattat cactgctttg aaggcggttt tagaagagat cggcgcggat gttgaaatag 1702561 aagaaacagt agagagcgaa aaatgctgtg atagcttaag aaaaaaaaat ctagactact 1702621 aagcagtttt ttttcatgtt atgatataca tcggctaaaa acgacacccc gagtaggacg 1702681 agagatgatt ctcgttctgc tctctttttt gggccctaat gagtctgccc gtttgcctga 1702741 tttgatcaaa atatgaattt ttcataaaaa cgaatctata tattgtgttt ttgctagagg 1702801 gtagtatact atatatagtg ttagtgatga gagattcata ttttttgata ggtcgtgata 1702861 aaacgtggta caaatcatat ttgattcgaa aacagggaat gttcagcggt ttgtgaataa 1702921 aacaggcttt cagcagatac gcaaggtgga cgaaatggac cacgtggaca ctccgtttgt 1702981 tttggtcacc tacacgacaa acttcggcca ggtaccggca tcaacacaat catttctcga 1703041 aaaatacgcc catctcttat tgggagtcgc tgcgagcggc aacaaagtat ggggcgataa 1703101 ctttgcaaaa agcgccgata ccatttcaag acaatatcag gtgccgatct tgcacaaatt 1703161 tgaactcagc ggcacatcta aagacgttga attgtttact caggaggtag aaagagttgt 1703221 cacaaaatca agtgccaaaa tggatccagt taaataacga aatcatgatc caaaaagatg 1703281 ggaaattcca gtttgataag gataaagaag ctgtacatag ctattttgta gattatatca 1703341 atcaaaacac agtcttcttt cacaatttaa aagagaagct ggattatttg gttgaaaacc 1703401 aatactacga agaggaattc ttaagccttt attcttttga agacattaaa gaagtgttta 1703461 agacagctta cgctaagaag tttcgttttc cttccttcat gagtgcgttt aaattctata 1703521 atgactatgc tttgaaaacg aatgacaaga aaaaaatcct cgagcgttat gaggaccgga 1703581 tctcaattgt tgcgctgttc ttcgctaacg gcgacactga gaaagcaaaa gaatatgtaa 1703641 acctgatgat caatcaagaa tatcagccga gcacaccgac atttttgaat gccggcagaa 1703701 aacgccgcgg tgaacttgtg agctgcttct tgctcgaagt taatgattct ttaaatgaca 1703761 tttcaagagc aatcgatatc tccatgcagc tttctaagct tggtggcggg gtttctctta 1703821 acctgtccaa gcttcgcgcg aaaggtgaag ccattaaaga tgttgagaat gcgacaaaag 1703881 gcgttgtagg cgtcatgaag cttcttgata acgcgttccg ttacgctgac caaatgggac 1703941 aaagacaagg ctccggcgcg gcgtatttaa acattttcca ccgcgatatc aatgattttc 1704001 ttgatacgaa aaagatttct gcggatgaag atgtgcgtgt caaaacgctt tcgatcggtg 1704061 ttgtcattcc ggataagttc gttgagcttg cacgcgagga caaagcggct tatgtattct 1704121 acccgcacac gatttataaa gagtacggcc agcacatgga tgagatggac atgaacgaaa 1704181 tgtacgacaa gtttgtcgac aaccctcggg tgaaaaagga aaaaatcaac ccgcggaaac 1704241 tgcttgaaaa attggcgatg cttcgttctg aatcaggcta tccatacatc atgttccaag 1704301 ataacgtcaa taaagtgcat gcgaataacc atatttccaa ggtcaaattt tctaaccttt 1704361 gctctgaagt gctgcaggca tctcaagttt cttcatacac agactatgat gaagaagatg 1704421 aaatcggtct ggatatttcc tgcaacctgg gttcgcttaa cattctcaat gtcatggagc 1704481 ataaatcaat cgaaaagaca gtcaagcttg cgacagactc tttaacacac gtgtctgaaa 1704541 caacagacat ccgtaatgcg cctgctgtaa gacgggcaaa caaagcgatg aaatcaatcg 1704601 gcctcggtgc tatgaacctt cacggctacc ttgcgcaaaa cggcattgcg tatgaaagtc 1704661 cggaagcgcg tgactttgca aacacgttct ttatgatggt gaatttctac tccatccagc 1704721 gttctgcgga aatcgcaaaa gagaagggcg aaacgtttga tcaatatgaa ggatcaacct 1704781 atgcgacagg tgaatacttc gacaaatacg tttcaactga tttctcaccg aaatacgaaa 1704841 aaatcgctaa tctgtttgaa ggtatgcata tcccgacgac agaggactgg aaaaagctaa 1704901 aagcatttgt cgctgaacac ggtatgtatc acagctacag attatgcatt gcgccgacag 1704961 gctctatctc atacgttcaa tcaagcacgg cgtctgttat gccgattatg gaacggattg 1705021 aagaacgaac atacggcaac tcaaaaacgt actacccaat gcctgggctt gcatctaata 1705081 actggttctt ctataaagaa gcctacgata tggacatgtt caaggttgtg gatatgatcg 1705141 ccactatcca gcagcacatt gatcagggaa tcagctttac attgttctta aaagacacaa 1705201 tgacgacccg agatttaaac cgaatcgatc tgtatgcaca tcatagagga attaaaacca 1705261 tttactatgc aagaacgaaa gatactgggc aagacagctg cctttcttgt gttgtttgat 1705321 taaaggagag tttatagtga caaaaattta tgacgcagca aactggtcaa agcatgaaga 1705381 cgattttacc caaatgttct ataaccaaaa cgtgaaacag ttctggcttc cggaagagat 1705441 tgctttaaac ggcgatctcc tcacatggaa gtacctcgga aaaaatgagc aggacactta 1705501 tatgaaggta ctggccggac ttacgcttct tgacacagag caggggaata cggggatgcc 1705561 gatcgtggct gaacacgtag atggccacca gcggaaagcg gtgctgaact ttatggcgat 1705621 gatggagaac gctgtccatg cgaagtcgta ctctaatatt ttcatgaccc ttgcaccgac 1705681 tgaaacgatc aatgaagtat ttgaatgggt taaacaaaat aaatatttgc agaaaaaagc 1705741 gcaaatgatt gtcgggcttt acaaagccat tcaaaaagat gatgaaattt cactgttcaa 1705801 agccatggtt gcttccgtct atctggaaag cttccttttc tacagcggtt tctattatcc 1705861 gttatatttc tacggacaag gaaaactgat gcaaagcggt gagatcatta acctgatcct 1705921 tcgtgacgaa gcgattcacg gcgtgtatgt cggtctcctt gctcaggaaa tttataataa 1705981 acagacagaa gagaaaaaag cagagcttcg tgaatttgcg atcgacctcc tgaatcagtt 1706041 atatgaaaat gagcttgagt atacagagga cttgtacgat caagtcgggc tctcacatga 1706101 tgtaaagaaa ttcatccgct ataatgcgaa taaagcgctg atgaaccttg gatttgatcc 1706161 atacttcgaa gaggaagaca ttaatccgat cgttttaaac ggattaaaca caaaaacaaa 1706221 atcgcatgac ttcttctcta tgaaggggaa tggctataaa aaagcgacag ttgagccgct 1706281 caaagatgat gacttttatt ttgaagatga aaaagagcag atataatatc tgctcttttc 1706341 ggcttgaagg ttcaaatgag gaggacgcag tacccatggg aaaaatggac gaaatgattt 1706401 tagttgcccc gcgcgatgat gtgtttaaaa aagaaagctt aaccttccag ggcgtgtaca 1706461 gtgaagatag cagagtagca gaaatcatgg ctcagattga agcggcctat cgtgaaatga 1706521 gaagagggga cgcagaagaa gatccgcgtt tcaagcagcc gataccttat gtcgtcatta 1706581 agcgtgaaga tgaagttttt ctttacgagc ggctggctgg cggcggtgaa tcacgtctgc 1706641 acaacaagct ttctctcggt tttggcggcc atatgaacgc catcgaaggg gcagcttcat 1706701 ttgctgaagt cttaaagctg aacacagacc gtgagcttga ggaagaactg caaataaatg 1706761 aagaagataa acaggcgatt gtcacactgg gattgatcaa tgatgatgaa aacagtgttg 1706821 gcaaagtgca tatcggtatt ctttctgcgc ttcaattaaa gcctggcgca caagtggaag 1706881 tgaaggagaa agaacaaatt gcgggtaaat ggatgaaagt ttctgaatta aaacaggatg 1706941 atatctacaa ccgtctggaa acatggtcac agtttgttgt tgatattctt gaataaaaaa 1707001 acccggtttc tcgcgatgag gagccgggtt tttttatgag acgctcgtcc ccgtctcggc 1707061 tatgattcta ggatcacaat agcgtcaaag ccggcatttt tcgctctggc agcgagggtg 1707121 tctgcattgt ctttggatga aaatgcgcca atctgcactt tgtataatcc gtcctttaaa 1707181 aggacaatcg agtcaaaacc tttggcttcg gcattacttg cgagcgagtc ggcattcgct 1707241 ttgactttaa atgcgccgat ttgaacctta tataaccctg agctggaagt ctttttaagg 1707301 ttaaaggctt gctccagccc gtttgcatgt cctctcgcta agctttgaat aaaactgctc 1707361 gttttcagct tatttgcatc ggaaacggta tcaatgaagc cgttctcggt caagagggca 1707421 ggcattgccg actcccttag gacgtggaag ttcgctgttt ttttgccgcg atcggcaaag 1707481 tcgacagctt gtatcacttc agagtgaatt gtcgattgat aagtcgtcgt cggggctcct 1707541 acatctggat aaatatagct ttcaaaacct gtgcctcccc cggaattaac gtgaatggac 1707601 aaaaagaaat ctgctcccca gttatttgcg gcatttgtcc ggtcgtttaa gctgacatat 1707661 tggtcgcttg tccggctcag cagcagagaa acgccttcat attcattagt taatatcgta 1707721 cgtaaggcta aagcgatttg cagggttaac gttttctcct gaaggccatt acctgttgcg 1707781 cctggatcag acccgccatg gccaggatca ataaaaattt taaccatttt tcatcacctc 1707841 attacaggat atgaaaaaac acggcttctg cttgtacgat tatcattcaa ctgaaaaatg 1707901 aggaaataac cctttcacat ccagaaatta tttctcggga aagcgcacaa ttcaacatga 1707961 agcgacaaca gatacggtcc gacatgaaat ctgtgcatac gccatatgtt tgtatgtact 1708021 atgggttcgg ttaacctgca ctgattcctg ctggttttaa gctttgcgtt catattaaat 1708081 caagcattta aaacgtaaat tgatgaggaa agctcctttc attaaagaca ccgctttata 1708141 aatcgaaaaa aagaaaaaca cttcaggtat cttagggcgg gtaatacgtt tcgtacaaaa 1708201 atcagcccgt tgtatgaaaa agaaataatg agaaagaagc tcactataat actctgacaa 1708261 aatgattaaa aacaaaatct catggtttgt ccaccccatg tccgtgaata caataagaaa 1708321 taaagtattt ctcgggaaag cgcaggattc cttattgttc ccgaaaaaag caattgtttc 1708381 gacacatgat aggcgtttgt cacaatcggc atccgcttga atatcatata gagagaacag 1708441 agaggtgaag atgttggagc gcgctgtgac ttataaaaac aacggacaga tcaacattat 1708501 tctgaacggg caaaagcagg tgctgacgaa tgctgaggca gaggcggaat atcaggctgc 1708561 attgcaaaaa aacgaagcaa agcacggcat tttgaaggaa atcgaaaaag agatgagcgc 1708621 attagttggg atggaggaaa tgaaacgcaa catcaaggaa atatacgcct ggatttttgt 1708681 gaaccaaaaa cgcgcggagc aaggcttgaa ggttggaaag caagcgctgc acatgatgtt 1708741 taaaggaaat ccgggaacgg gaaaaacgac ggttgcacgg ctcatcggca agctgttctt 1708801 tgaaatgaat gtcctgtcaa aaggccactt aatagaagcg gagcgggctg acctggtcgg 1708861 ggagtatatc ggacacaccg cccaaaagac gagagattta atcaaaaagt cattaggtgg 1708921 cattttgttt atagacgaag cctactcgct ggcaagaggc ggcgaaaagg actttgggaa 1708981 agaagcgatc gacacacttg taaagcatat ggaagacaaa cagcatgagt ttattttgat 1709041 actcgccgga tattcacggg aaatggatca ttttctctcg ttaaatcccg gactccaatc 1709101 aagatttccc atctccattg attttccgga ttactctgtg acccagctca tggagattgc 1709161 gaaacgaatg atcgatgaaa gggaatacca gctcagtcaa gaagcggaat ggaaattgaa 1709221 agattactta atgacagtga aaagcacgac aagtcccatt aaattcagca atggacgttt 1709281 tgtcagaaat gtgatcgaaa aatcgatcag agcacaagcc atgaggcttt taatgggaga 1709341 ccaatactta aaaagcgact tgatgaccat caaaagccaa gatctttcca ttaaagaaga 1709401 agcatctgga tctgcataga cctctcagtt tttgagaggt ctgttttttg ctcgtatttc 1709461 cgcttttcaa agcaatcgat ttgtggtata cacatgcagg gtttggtatg ataatactac 1709521 tgcccaatat gcaaaagaaa ggaacatcca tttgaacgaa caagaaacga ttcaggagaa 1709581 agccatttta gtcggatgtc agctgccgca tatcacggat gagcattttg aaaattctat 1709641 ggaagagcta gcatctctga cgaaaacagc agacggaaaa gtactgacca gcgtcacaca 1709701 aaaacggaac agggctgacg ccgctacata tataggaaaa gggaaggtag aagagctgaa 1709761 ggcactcgtg gaagagcttg aagctgatct cctcatcttt aatgatgaac tgtcgccaag 1709821 tcagctgaag tcattggcaa cagcaattga agtgaagatg attgaccgca cgcaattgat 1709881 attagatatt tttgcaaagc gggcgagaac gagagaaggc aaacttcaaa ttgagctggc 1709941 tcagctgcaa tatgcactgc cgcgtctgac gggacaaggg atcaaccttt cccggcaagg 1710001 cggaggaatt ggggcaagag gtcccgggga aacgaaactg gaaaccgacc gccgccatat 1710061 cagaaatcgc attcatgaaa tcaacacaca gctttccact gtcattcgcc atagaagccg 1710121 ataccgtgaa agaagaaaga aaaacggtgt gcttcaaatt gcgcttgtcg gctatacaaa 1710181 cgcagggaaa tcaacatggt tcaaccgcct gacgagtgct gacagctatg aagaagacct 1710241 cctgtttgcc acgctggacc cgatgaccag aaaaatggtc ctgccaagcg gctacagtgt 1710301 tcttctttca gatacagtag gatttattca ggatcttccg acgacattga ttgctgcatt 1710361 ccgctcaacg cttgaggaag taaaagaagc ggatttaatt ctgcatttaa ttgattcttc 1710421 aaatgaggat tatgcgggac atgaaaaaac agtgcttcgg ctgcttgagg agcttgaagc 1710481 agatgatatc ccgatgctga cggcttacaa taaacgtgat caaaaactgc ctgattttat 1710541 accgaccgcc ggaagggatc acattatggt cagtgcgaaa tttgaggacg acgctgcagc 1710601 ctttaaagaa gcgattcagc gctatttgcg ccaagaactg ttaacgtctt ttgaagcaca 1710661 tgtgccggca agtgaaggga agctcctttc cagaatcaaa tcggaaacga tggtagaccg 1710721 cttctatttt aatgaagaaa atgaacagta tgacatatcc ggctatgtcc aagaagagca 1710781 aagtatcatc ggtgaattaa agaagtatat gtaggaagga aatataaaga catgtttgac 1710841 acattaacac acggagaatt attgaagaaa acggcaatgg aagtggaagc ggacattgcc 1710901 ggcattcata aacaaataga agaaatcagc gagcgaaatg agtggagagt gcttcaaagc 1710961 tatagaaaac acaaagtaag cgacactcat ttcacgccgt ctactggata cggctatgat 1711021 gatatcggaa gagacacgct tgaaagcata tatgcggatg tgtttggcgg agaagcgggg 1711081 cttgtaaggc cgcaaatcat ttcaggcaca catgccatct caattgcttt gttcggtgtc 1711141 ctcagaccgg gggacgagct cctttatatc acgggcaagc cgtatgatac gctagaggaa 1711201 attgtgggcg tcaggggtgg agaaaacgct ggttcgttaa aggattttca aatcggctat 1711261 aatgcggttg atctgacgaa agacggaaag atagactatg atgcagtcgc cgctgcgatc 1711321 aatccgaaga caaaagtaat cggcattcag cgctcaaaag gatatgcgaa tcgcccttct 1711381 ttcttaatta gtgaaataaa agaaatgatc cgttttgtaa aagaaatcaa tgaaaatctg 1711441 atcgtctttg tggacaactg ttacggagaa tttgtggaag agcttgagcc ttgccatgtc 1711501 ggagccgacc tgatggcggg atctctcatt aaaaatcccg gcggcggcct tgcgaaaaca 1711561 ggcggctacc tcgtcggaaa agcgaaatgg attgaagctt gctcataccg tatgacgtca 1711621 cccggcatcg gcagagaagc gggggcatct ctttactcgc tccaagaaat gtaccaaggc 1711681 ttctttttgg cgcctcacgt tgtgtctcaa agtttaaagg gagcggtgtt tacagcgaga 1711741 ttccttgaaa aactcggctt cacttcaaac ccgaaatggg atgcgaaaag aacggattta 1711801 atacaatccg ttgagttttc tgacagagaa aagatgattg ctttttgcca ggctattcaa 1711861 tttgcatcgc caatcaatgc tcatgtgacg ccttatccag cctacatgcc tggatacgag 1711921 gatgatgtca ttatggcagc agggacgttt attcaaggag caagcatcga attatcagct 1711981 gatggcccta tccgcccgcc gtatgtagcg tatgttcagg gaggattaac ctattcgcat 1712041 gtgaagaatg ccatatgcag tgcagtggat tcattgatgc aaaagcaatt aatttaaatt 1712101 ttttaaaaat ttctctggat ttgatgttaa gaatccttac atcgtattga cacataatat 1712161 aacatcacct ataatgaaac taagttaaga aaaggaggaa attgagatga gtgataatat 1712221 tcgccgctca atgcctttat ttccaatagg aattgtcatg cagttaactg agttatcagc 1712281 aagacaaatt cgatattatg aggaaaatgg actgatattt ccagccagaa gtgaaggaaa 1712341 tagacgatta ttttcatttc atgatgtaga taaactgtta gaaatcaagc acctgataga 1712401 acaaggtgta aacatggcag gaattaaaca gattctggcg aaagccgaag ccgagccaga 1712461 acaaaaacaa aacgagaaga cgaaaaaacc aatgaaacat gatctgtccg atgacgaact 1712521 gagacagctc ctgaaaaacg agctcatgca agccggccgt tttcaaagag ggaatacatt 1712581 ccgtcaaggc gacatgtccc gcttctttca ttaatccgtt agcaactgtt ttgctatata 1712641 catttacctt ttaagaggag gaattttacc aaatggcaaa gtacactaga gaagatatcg 1712701 aaaaattagt aaaagaagaa aacgtgaagt atatccgcct tcaatttact gacattcttg 1712761 gaacaatcaa gaatgttgag attcctgtaa gccagcttgg aaaagcgctt gataataaag 1712821 tcatgtttga cggttcttct attgagggat tcgttcgtat cgaagagtca gacatgtacc 1712881 tgtatccaga tctaaataca tttgttatct tcccatggac agctgaaaaa ggtaaagtag 1712941 cacgtttcat ctgtgatatt tacaatccgg atggcacacc ttttgaaggt gacccgcgaa 1713001 acaacttaaa acggattctg aaagaaatgg aagacctcgg cttcagtgat tttaaccttg 1713061 ggcctgagcc tgaattcttc ttattcaaat tggacgaaaa aggcgagccg acgcttgaac 1713121 taaacgacaa aggcggatat ttcgacttag ctccaactga tttaggagaa aactgccgcc 1713181 gcgatatcgt acttgagctt gaagagatgg gctttgaaat cgaagcgtct caccacgaag 1713241 tagcacctgg tcagcacgaa atcgacttta aatatgctgg agcagtccgc tcttgtgatg 1713301 acatccaaac atttaaacta gttgtcaaaa caattgcccg taaacacggc ctgcatgcga 1713361 catttatgcc aaaaccattg ttcggtgtaa acggttcagg tatgcactgc aatctatcac 1713421 tcttcaaaaa tggtgttaac gcattctttg acgaaaacgc agatcttcag ttaagtgaaa 1713481 cagcgaagca cttcattgca ggtatcgtga agcacgcaac aagctttaca gcagtaacaa 1713541 acccgacagt aaactcttac aaacgtcttg ttcctggcta tgaagcacct tgttatgtag 1713601 catggagcgc gcaaaacaga agcccgctta tccgtatccc ggcttctcgc ggcatcagca 1713661 cacgtgttga agtacgcagt gtagacccag ctgcaaaccc ataccttgca cttagcgtat 1713721 tgcttgctgc aggattagac ggaatcaaaa acaaactgga agcgccggct ccaatcgacc 1713781 gcaacatcta tgtgatgagc aaagaagagc gcatggaaaa cggaatcgtt gaccttccag 1713841 caacacttgc ggaagcacta gaagaattca aatcaaacga agtcatggtc aaagcgctgg 1713901 gcgagcacct attcgaacac ttcatcgaag caaaagaaat cgaatgggat atgttccgca 1713961 cgcaagtaca tccttgggaa cgcgaacagt atatgtctca gtattaatat ctcaatccct 1714021 tggcactaaa agtgtcaggg gattttttat gttaataggt aataaattat ggagcggcat 1714081 agtgtttaac acagccatta atcctcagac agtcaaatag ccatttctac tccggttgaa 1714141 agcttctcta tttttgcttc ttatttatct ttcctgtatt gatatatgta tgtagggttg 1714201 gacttataac ataaactatt ctggccattc cgttctttca attcatgacc gggcttgcca 1714261 tcagcataaa tctaggctaa cagtctccat acatcctgtg atcaccttta tcaaactctt 1714321 aaatgcaact taccactaac caattcttta tttcgcatag atcatctttg tcatgtgttt 1714381 acacaagaat ctgttttgga ctgagacact gaatataaca aaacagtcaa aaatcaatat 1714441 ttaattcatt ctgtttaaac tttctgaaaa agatgttgaa aaagtcgaaa ggattttata 1714501 atattaagtc aagttagttt gtttgatcaa caaactaatg aaatgaactt tcattatcca 1714561 caagataaga tcttactaat atggatggaa gggggataag agggtcgatt taatggagct 1714621 aaacaatata agaaacgaaa gaatgaggct tttatccttt tccaggtata taaggtatga 1714681 cgaaaaaaga tgaatttttt gcttgctgat caccatattt ttttgcactg ttttgaaagc 1714741 gcttttataa aagtttactg accgtaaatt cgagaaattg ttataccgtt tcacactgtt 1714801 ccatattaaa ggatcgaaaa ggggagaaat catgctcagt gaaaatgtaa agaagattag 1714861 catggttgaa aaagttggat atgcgtctgg agattttgct tgtaatttaa tttatgcaac 1714921 agtgtctacg tatcttttgt tcttctatac agatgttttt ggtttatcgg cagcagcagc 1714981 cggtactatg tttttagtgg ttagaataat cgacgctctc gctgatcctt ttatcggaac 1715041 aatagttgac agaacgaaca gcagatttgg acgctttaga ccgtatcttt tattcggagc 1715101 ttttccattt gtcatactgg caatactctg ttttacaaca ccagactttt cggatatggg 1715161 gaaattaata tatgcctata taacctatgt tggcttgtcg cttacataca caacgataaa 1715221 cgttccatat ggcgcgttaa cttctgcaat gactagaaat aatcaagaag ttgttagtat 1715281 aacttctgtt cgcatgttat ttgcgaatct tgggggactt gtcgttgcat tttttgttcc 1715341 cttactggct gcttatttaa gcgatacttc cggcaacgag tctcttggct ggcaactaac 1715401 catgggtatt ttgggaatga taggcgggtg ccttttaatc ttttgtttta aaagcacaaa 1715461 agagcgggtc actcttcaaa aatccgaaga gaaaattaaa tttacggata tatttgagca 1715521 gtttcgtgtt aatcgtccac ttgttgtatt aagtattttc tttattatta tttttggagt 1715581 gaattccatc agtaattcgg ttggcattta ctacgtaacg tataacttag aaagagagga 1715641 tttggtgaag tggtacggtt tgataggaag tttacccgct ttggtcattt taccgtttat 1715701 tccaaggctt catcaatttt tggggaaaaa gaaattacta aactatgcat tattactgaa 1715761 tattataggc ctcttagctt tactgtttgt tccgccaagt aatgtttacc tcatacttgt 1715821 ctgtcgatta atcgctgctg ctggaagtct cactgccggg ggatatatgt gggcgcttat 1715881 tcctgaaaca attgaatatg gagagtacag gactgggaaa agaatgggtg ggctcattta 1715941 cgctataatc ggatttttct ttaagtttgg tatggcctta ggaggagttg ttccgggtct 1716001 ggttcttgat aagtttggat atgtagcaaa tcaggcacaa accccggcgg ccttaatggg 1716061 gattttaatt acaacaacca ttattcccgt gttcttgctt gttctagctt taattgatat 1716121 taatttctat aacttagatg agaaaaaata taaaaacatg gttcgagaat tagagaatag 1716181 agacaaagtt tatttggatc atattgatga tttcaaggct taaaaaagaa aataaactga 1716241 ggaggagtcc caaatgaaga ttaccaatcc cgtacttaaa ggattcaatc ccgatccaag 1716301 tatttgtaga gcaggagagg attattatat cgctgtatct acatttgagt ggtttccggg 1716361 agtccagata caccactcaa aagatttagt aaattggcac ttagttgcac atccattaca 1716421 gagagtttca caattagaca tgaaaggaaa cccaaattca ggtggagttt gggcaccatg 1716481 tttaagctat agtgatggga agttttggct gatctatacg gatgttaagg tagtagatgg 1716541 cgcatggaaa gattgtcaca attatttagt tacttgtgaa acgattaatg gtgattggag 1716601 tgagccgatt aaattaaata gctcggggtt tgatgcttct ttgttccatg atacggatgg 1716661 aaaaaagtat ttattaaata tgttatggga tcaccgtatt gatcggcact catttggagg 1716721 aattgttata caggaatatt ctgataaaga gcaaaaatta atcggtaaac caaaagttat 1716781 atttgaagga actgatagaa aactgacaga agctccgcat ctttatcata tcgggaacta 1716841 ttattattta ttaactgcag aaggaggaac acggtacgaa catgctgcta caattgctcg 1716901 ttctgcaaat attgaggggc catatgaagt tcatcccgat aatccaattt taacgtcatg 1716961 gcatgaccca ggaaatccat tgcaaaaatg tggtcatgca tccattgttc aaacacatac 1717021 agatgagtgg tatttagctc atttaacggg acgtcctatt catcctgacg atgattcaat 1717081 ttttcagcag agaggatact gtcctttggg cagagaaaca gctattcaaa aactttactg 1717141 gaaagatgaa tggccctatg tagtaggtgg aaaagaagga agcttggagg tagatgcacc 1717201 ttctataccc gaaacaatat ttgaagcaac gtacccggaa gttgatgaat ttgaggattc 1717261 aacattaaat ataaattttc aaactttaag gattccattc acgaatgaat taggttcatt 1717321 gactcaagcg ccaaatcatt tacgattatt cggtcatgaa tcattgacct cgacatttac 1717381 tcaggcattt gtagccagac gctggcaaag tctccatttt gaagccgaaa ctgctgttga 1717441 gttttatccg gaaaattttc aacaagccgc tgggttggtg aattactaca atacagagaa 1717501 ctggacggct cttcaagtca cgcatgatga agaacttggg cgcattcttg aattaacaat 1717561 atgtgacaac ttttcttttt cacagccatt aaataataaa attgttattc ctcgtgaagt 1717621 aaagtatgta tatttaagag taaatattga aaaggacaaa tattattatt tctattcttt 1717681 taacaaagaa gattggcaca aaattgacat tgcactggaa tcgaaaaaat tatcagatga 1717741 ttatatccgt gggggaggat tcttcacagg ggcctttgta gggatgcaat gccaagatac 1717801 cagtggtaat catattccgg ccgactttag atattttcgt tataaagaaa aataatttgc 1717861 acatgaaaaa ggagatttct attttagaac tcctttttca tatgagaagg tgccatgtca 1717921 ctattgcttc agaaatactc ctagaataaa aaaactcatc tttaaagatg agctgtccat 1717981 tccataaaaa attacattgt aatcatgtcc agaaaatgat caatcacaat ggaggacatt 1718041 cctaatgccg gtgcattctg tcctaaggaa gatggcaata attcatagct attgcctaat 1718101 tgggaataaa cccttgatga tacttcactt ctcattgaat ttaaaaccat aggatgcgat 1718161 tcaattatgc tatttcttaa aattacggct tgtgggttga aagtatttag aatattggta 1718221 aggcctattc ctaaatagaa tccaaaattt tgtaatgcat ttaaggttcc gatatcattc 1718281 agatgggcga ggtttatgat atcttgatag gacagttttt tctctttggt ctgaagagat 1718341 tttaataaag ccttctctga agcatacaat tcccagcatc ctcggtttcc gcaactgcat 1718401 ttaggaccat taaagtctat tgtcatatgt cccatttctc cagagaagcc gcttactcct 1718461 ctatataaat gattgttgat aataacaccg atccctattc ctgtgctgat acttacgtaa 1718521 ataatgttat cgtgattttt tgcagctcca aatacttttt ctccatatgc gccagcattt 1718581 gcctcatttt caataaaaac aggcacattg tacttctctt gtatcgaaga ttttaagtca 1718641 atatctctcc agttggagtt cggagtgaaa acaatttttt gatctttatc aatgagtcca 1718701 ggcacgcaaa tacctatacc aataagcccg tacggagatt ggggcatttg cgtaataaag 1718761 tgatgaatca tatcaatcaa aatgtctttc gttatttctg gagaattgga ttccaaatgg 1718821 cggtattgat caagaacgat tgttccttca aggtctgtta aaatgccatt aatataatcc 1718881 acaccaacat ctattccaac ggagtatcct gcctttttat taaaaacaag catgacaggt 1718941 cttcttccgc cacttgattg tccttgacct atttcaaata ccatactttc tttcattaac 1719001 gtgtttacct gtgatgagac agttgattta tttaatccag tcatttcaga taattttgct 1719061 cttgaaatag gtgaattttt aaggatttct tttaataata acttttgatt tacttttttg 1719121 acaaaggttt gatcagcgat atccacttca tccactccat ttgtttaatc tttaaattaa 1719181 gtatcaacat agtacatagc gaatcttccc tttattatat ctaatgtgtt cataaaaaac 1719241 taaaaaaaat attgaaaata ctgacgaggt tatataagat gaaaataagt tagtttgttt 1719301 aaacaacaaa ctaataggtg atgtacttac tatatgaaat aaaatgcatc tgtatttgaa 1719361 tgaatttatt tttaaggggg aaatcacatg gctcaatctc attccagttc aatcaactat 1719421 tttggaagcg caaacaaagt ggtttacgaa gggaaagatt cgactaatcc tttagcattt 1719481 aaatattata atcctcaaga agtaatcggc ggaaaaacgc tgaaagagca tttgcgattt 1719541 tctattgcct attggcatac atttactgct gatggtacag acgtttttgg agcagctacg 1719601 atgcaaagac catgggatca ctataaaggc atggatctag cgaagatgag agtagaagca 1719661 gcatttgaga tgtttgaaaa actagatgca ccattctttg cttttcatga ccgggatatt 1719721 gcaccagaag gcagtacgct aaaagagaca aaccaaaatt tagatatgat catgggcatg 1719781 attaaagatt acatgagaaa tagcggcgtt aagctattat ggaatacagc aaacatgttt 1719841 acgaatcccc gtttcgtcca tggtgccgcg acttcttgca atgcagatgt gtttgcgtat 1719901 gctgcagcac aagtgaaaaa agggttagaa acagcaaaag agcttggcgc tgagaactat 1719961 gtattttggg gcggccgtga aggatatgaa acattgttaa ataccgattt aaaatttgag 1720021 cttgataatt tggctagatt tatgcatatg gcagtggatt atgcgaagga aatcgggtac 1720081 acagggcagt ttttgattga gccaaaacca aaagagccga ccacccatca atacgataca 1720141 gatgcagcaa caaccattgc ctttttgaag caatatggct tagacaatca ttttaaatta 1720201 aatcttgaag ccaatcatgc cacattagcc gggcatacat tcgaacatga attacgcatg 1720261 gcaagagtac atggtctgct tggctctgtt gacgcaaacc agggtcatcc tcttttaggc 1720321 tgggacacgg atgaatttcc gacggattta tattctacga cattagcaat gtacgaaatc 1720381 ctgcaaaatg gcggccttgg aagcggcgga ttaaactttg acgcgaaggt cagaagatct 1720441 tctttcgagc ctgatgatct aatatatgcc catattgcag ggatggatgc atttgcaaga 1720501 ggattgaaag ttgcccacaa attaatcgaa gatcgtgtgt ttgaagatgt gattcaacat 1720561 cgttaccgca gctttactga agggattggt cttgaaatta tagaaggaag agctaatttc 1720621 cacacacttg agcaatatgc gctaaatcat aaatcaatta aaaacgaatc tggaagacag 1720681 gagaaattaa aagcgatatt gaaccaatac attttagaag tataacagga taagctccag 1720741 atcctgctat caataccaag tcactgaatt acccgtcatg attcctttcc tattgcttgt 1720801 tgttatgacg ggtaacttct ataattagga tttatttaga gtgaatggtt ttttaaaagg 1720861 gcaaggagtg aaaaaatgaa gtatgtcatt ggaatagatc ttggaacgag tgctgttaaa 1720921 accattttag ttaaccaaaa cggcaaggtt tgtgcagaaa cgtccaaaag gtatccgctc 1720981 atccaagaga aggcgggata tagtgagcaa aatcctgaag actgggttca gcaaacaatt 1721041 gaagcattgg ctgaattggt ttctatatcc aatgttcaag ccaaggatat tgacgggata 1721101 agctattcgg gacaaatgca tggattagta ctgcttgacc aagatcgtca ggtgttacgt 1721161 aatgcaattc tttggaatga taccagaaca acgcctcaat gtataaggat gaccgagaaa 1721221 tttggcgatc atcttcttga catcacaaaa aaccgtgttt tagaagggtt tacattacct 1721281 aaaatgttat gggtaaagga acatgaacct gaacttttta aaaaaactgc tgtgtttttg 1721341 cttccgaaag actacgtgcg attccgtatg accggtgtca ttcacaccga atactccgat 1721401 gcagcaggaa ctttactttt acatattact cgcaaggagt ggagcaatga tatttgcaat 1721461 caaattggta tttctgcaga tatttgtcct ccgcttgttg aatctcatga ttgtgtagga 1721521 tcgctgcttc cgcacgttgc cgcgaagacc gggctattag aaaaaacaaa agtgtacgct 1721581 gggggagcag ataatgcttg cggcgctatt ggagcaggta tcctttcttc cggaaaaaca 1721641 ttatgcagta ttgggacgtc aggggtcata ctttcctacg aagaagaaaa agaaagagac 1721701 tttaaaggga aagtccactt ttttaatcat ggaaaaaagg attcttttta tacgatgggc 1721761 gtcacgctcg ctgcaggata cagcttggac tggtttaaaa gaacgtttgc accaaacgaa 1721821 tcgtttgagc aattattgca gggggtggaa gctattccga taggagccaa tggactgcta 1721881 tacactcctt atttggttgg tgaaagaacg ccgcatgctg attcttctat tcggggaagc 1721941 ttgatcggaa tggatggagc ccataataga aagcattttt tgagggcaat aatggaaggt 1722001 atcacattct ctttacatga atcaattgag ctattccgcg aagcgggaaa atcagttcat 1722061 actgttgttt ctattggtgg gggagctaaa aatgatacgt ggctgcaaat gcaagctgat 1722121 attttcaata cgagggtaat taagttagaa aatgaacaag ggccagctat gggggctgca 1722181 atgctggctg cctttggaag cggttggttt gaatcacttg aagaatgtgc agagcagttc 1722241 attcgtgagg ctgctgcatt ttatccaaag gcgcaaaatg ttcaaaaata taaaacacta 1722301 tttgatttgt ataagaacat ttacactcac acaaaggatc tcaatacagc tttgaagagc 1722361 tttcgaaaaa actaatgatg ttattgtctg gagatcaacc gaagaacaat taatgatcaa 1722421 tcatcatcaa aggcctttga taacatggct gccttctttt gaaaagatgg tgagaataag 1722481 gtatcgcaac ctttaaacag tattggagta tccagcagac aaaacgaacg agtggaaccg 1722541 tattttgtca gcgaacactt caagaagtgg ggaagcttag gaatgccaat gggtaagatg 1722601 tatgaaaccg cgctaacgac ggtagaggga tctcttgatt tatgaagaaa taggaaggat 1722661 gttaacacac aaataacccc tcacattgac gtgaaggggt gttttttatt gttactatac 1722721 agcggaaatt ttacaggcta gttgcatgat tttagcttgt taagcagaat ggaactagac 1722781 tctccatcat ctctttctca ttctttggaa actgcattct gctaggtttg ctgctttttt 1722841 taacaaacag tgtttttcta tttcacacag ccattaaatc ctctgttcgt cacataaccg 1722901 ctcttactcc aaattgacag tttatctgat tttgcttctt gctcatctag tctgaattgg 1722961 tctatgtatt ttgtgttagg ctcatataca tatgctactc tggccaatcc ctctttcaat 1723021 aatgtctctt gaacagattt gccgtcaaca taaacgtatg ctaacagtct tccatactta 1723081 tctctgcgat cgcctttatc aaattccagc tgtagcttac cgctgttgac caattcttta 1723141 tttcgtttcg acgcatcctc accgtatggt tgaacacaag aatttggttt cttcgtctca 1723201 ggtgtatcaa cgagcaagta gcgaactgtg tctttctttc cgttgtaaat aaccttaatc 1723261 gtatctccat ctattgctct atctaatgta acattgacca atttcttctg attttttgaa 1723321 tgaggcgtgc cagccttttg ttctgtctga ttatattcat tagagtgagt atcttgagag 1723381 acttgctccg tcccattaga atctgaatgg tttttggctg cgtgatttga tccgcaagct 1723441 gccaaagtaa tacttaaaac gattgcgatc atactgatca aaatcttctt catattgatt 1723501 ccctctttat cattttctct tttcgcgatt aaacatcatc attataacga tatggacatt 1723561 ttttgtgaat ggaaaacttc aagggaactt ataacactcc aaattgccaa tagttaactt 1723621 cacaacgaga tgatcaaaac atcaccatca catagcggaa ataaataatc ctgaaaataa 1723681 tattgactga aaatgctttt agaattatga taatatgaga aatgacaata atgtgacaaa 1723741 gacattacta caacataaca actaatagct taggtttatt ctattggtta aaaatgtaaa 1723801 cggttacaaa tccagaggcg aaaatctaag atagagatga ctttagtttt gactcaatat 1723861 ccacactgaa agagcttatt aagtattctt aaaggcaggg gaaatggata tgaatgaaca 1723921 tcgaaatcga aggttgaaat taataatgat ttcagcaact tttggagggc ttctctttgg 1723981 atatgacacc ggagttataa atggagcttt accttttatg gcaaggccag atcagcttga 1724041 tttaacacct gttacagaag ggcttgttac gagtattctt ttattaggtg ccgcgtttgg 1724101 agcgttgtta tgcggaagat tggctgatcg atatggccgc cgtaaaatga tccttaatct 1724161 ttccttttta tttttcctgg catcactggg aacagcgtta gcacctaatg ttttcatcat 1724221 ggcggtcttt cgttttttac tggggctggc tgttggagga gcctcggcga tggtgccggc 1724281 ctttttagca gaaatggcac cgcatgaaaa gagagggcgt atggtaaccc aaaatgaact 1724341 aatgattgtt ggcgggcaat ttttagcata tgtttttaat gcgatcctcg gtgtaacaat 1724401 ggcaaatacg ggacatgttt ggagatacat gctagtcatt tgtgctgtac cggctatcat 1724461 gttatttgcc agtatgctta aggtaccaga aagcccccga tggctaatct ccaaaggcaa 1724521 aaacagtgag gcgctgcgag ttcttaaaca aattcgagaa gataaacgtg cagaagctga 1724581 atgtagagaa attcaagaag cggtagaaaa agatacagca ctagaaaagg catcactcaa 1724641 ggacttttct acaccatggc tgcgccgtct tttatggatt ggaatcggtg ttgccatcgt 1724701 gaatcaaatt acaggtgtga actcgattat gtattatggc acacaaatcc ttaaagaatc 1724761 tggttttggt acaaaagcgg ctttaatcgc taatattgga aatgggctga tatcagttat 1724821 tgcagttata tttgggattt ggctggtcgg aaaagtgaga cggcgtccaa tattattgat 1724881 tggtttggca gggacgacta cagcgctcct attgattgcg attttctcaa ttgtgcttga 1724941 tggatctatg gcacttcctt atgtagtgct ttctttgacc gttttatttc ttgcctttat 1725001 gcaagggtgt gtaggacctg tgacttggct tgtcatagcg gaaatattcc ctcaaaggtt 1725061 aagaggactt ggttctggga taagtgtttt tttcctttgg atattaaact ttgtgatcgg 1725121 ttttgctttc ccgatcttgc ttagctctgt aggtttgtct tttacattct ttatatttgt 1725181 ggctttaggt gtattggcaa tcggttttgt gtacaaattc atgccggaaa caaaagggcg 1725241 tacacttgaa gaattagaag agcattttcg ttctcgacac gatcataata ctcctgaaca 1725301 atcagttatt gaggtataaa tatgttgaaa atctctcttc ttataggagg gattttttta 1725361 gtttcagaaa aaacaaaatc cctctggtag agggattttg attcagcatt ttaagatgtt 1725421 ctacacgtat aatactggag ttgatacttt aaaaatctcg ccatctctta tataaaaacg 1725481 agggatgcgg cggcttaatg tagacacgac ttcatagtta atcgtattga gcatttcagc 1725541 cacttcatca acggaaatct cggctccttt ttgcttaccg taaatcacga cttcatctcc 1725601 ttgtttacct tcaccgtttt ctcctaaact gaccatgatc atatccattg ttactcttcc 1725661 cgccactggc actcgttttc cgcgatgaag aacaaacccg cgattggaaa gggcacgaga 1725721 atagccgtca gcatagccaa tcgggagtgt agcaattact tcattaggtt ctgcgatgta 1725781 tgtagcacca tagctaacgg ttcggggttc tgtccgcatg gttttcacat aagcgatgcg 1725841 tgcctttaaa cttaacgcag gttcaagctt aacgagattt agttgtttaa tataggctga 1725901 aggatataaa ccatataagc cgatacctaa acggatcata tcagcgctaa attccggaaa 1725961 tgcgatagct gcagccgtgt tgcacatatg cacggtgggc agctcaatcc cctgtttttt 1726021 taaaaagctg agaaaactga tgaatttttc atgctgcagc tttgtgagtg ttgtgtccgg 1726081 ttcatcagct gtcgaaaaat gtgtgaaaat ccctgtccat ctgaggaatt tacttgcctt 1726141 taaggctttc actacctcta aaagttcttc ctttgtgcgt acacctaatc gtcccatgcc 1726201 ggtatccacg ttaatatgaa tggccagccg gttagcactc gcttcttttt ccaatatctc 1726261 gtttgcttct ttcatccaat caacctgaaa tgctgataat gttatattcc aagctgctga 1726321 cttctttaca caactaaggg atgtaaaacc aagcacaagg ataggtgctg taatcccagc 1726381 tttacgtaaa acgattcctt cctccacact ggcaacagcg agctcactcg ccccgtgttc 1726441 cagtgcatgg cgtgccactt ctatagaccc gtggccataa ccgttcgctt ttacaacagc 1726501 cataattttg ctcttatgtg gaatatgacg gcggatcgct cgcaaattct ttttaacggc 1726561 atcaagattg acttcgatcc aaacttctcg gcaaagcttt atcatcaacg cttccttcct 1726621 tcttatggat tataaatacc acctattgcc gcaagaataa atgttaattg ttggatgatt 1726681 cgatcttatt ttattcaact ttatttgaaa tcattcaaca gcaaatccat gtgatacgag 1726741 aaggtgccta tcaatgttcg aataatagca agtacgggat acatgaggct tgtaagtggg 1726801 gtgttaatgg atgcggcgac cgaggattac aaaaatgatt atttgttttg ggacattttt 1726861 ttctaagggt agatgataac gagaaatcta atcaggaaat acttaccgtt gttatgaaca 1726921 ttgaagaacc ttttaaatga gaagggctga ggaaattctg taaaagataa tcggttgaaa 1726981 aggcagtcga ttccttgttc cataaaccta acatcagagt atataattat actcgtattc 1727041 acaaaaatcg tttaagtaag gggtatacat gaatagggga gttagttttc aaataccgaa 1727101 tgaatatgga aattttctat ggagaatact gcagccggta gaaatagcta attataggtg 1727161 gcaaacgagt ggggaatctt attttgttgt agaaggagag ctcgatgatg aggagctttt 1727221 tcatgactac gaaattgttg agggggcagt ttttgagcaa caattaaaaa cgaatcagta 1727281 ctataccatt ttcgttgaac tgaaagcatt tccatatgga aaaatggtta atcaagtcaa 1727341 tacatatgaa gagtttgctg acagtgattg cgaacttgtc cttttgatag cagataatag 1727401 ctacgtttcg atttactgta aaaacaaaaa tatcattgaa aaactttact tcaatgcttt 1727461 acagcatgat tttgaagacg ttcaatttat aactgatgaa aatgacacaa gaacaagcct 1727521 tactgtatga tactcaataa aaattaaagg agctagtaca tgacaatgca aattaaaatc 1727581 aagtatctag atgaaacaca aacaagaatc agcaaaattg agcagggaga ctggattgat 1727641 cttcgggcag ctgaagatgt aacaatcaaa aaagatgaat ttaagcttgt cccattaggt 1727701 gttgcaatgg agctgcctga aggttacgaa gcacatgtcg tccctcgttc aagtacatat 1727761 aagaactttg gcgttattca aacaaattca atgggtgtta tcgatgagtc atataaggga 1727821 gacaacgatt tctggttctt tcctgcttat gcattgcgtg atactgaaat taagaagggt 1727881 gatcgtatct gccagtttag aatcatgaag aaaatgccgg cggttgaatt ggttgaagtc 1727941 gagcatttgg gaaacgagga tagaggagga ctcggttcaa caggtacgaa gtaaacaaaa 1728001 taaatccttg gctgtcttca tgctgtgtga ttgatcaatg gaggtttcag ccaaggtaca 1728061 tataaatatt atgtataaaa tgaatatttt aatacgaagg atttaattaa aaacaaagtt 1728121 taaaaaggga agttttgaaa aagtgaaata gtaataacta aagtcgataa agaacctaaa 1728181 gatgtcaaag aaacaatttt tctggtgctt tgcttttttg aaggtttact tagctcgtgg 1728241 ataactgccc cccataaaag catggatgct aaaattataa tacttatata cataaagatg 1728301 ctccttttat tatatttaca gtttttacat ttttatcgat tttaccacat ttaggattga 1728361 gttgtcgatg aaacaagcat ctctataaag aaatactttt atctaaattt ttataaatag 1728421 gggaaggcaa ctaaaaacta gtaatgccac taataataag ccaagttaaa tgacttgtgt 1728481 tcattaataa ttgaatttta cagcagccat gagcacaaaa aaatctgagt tcgtcgataa 1728541 atatcataaa aaagcccccg gtatgtcgcc agggaataaa tagacgttta agagatttag 1728601 tgatgttttt tatatgattc gacaaaatca taataatgat catcgtcatc ataatacttt 1728661 ttttcgtaat gataatcgtg atcatcgtaa tactttttat catggtcatc atactttttg 1728721 tcgtaatcat aatgtttttt atcatgatca taatacttgt cgcaatcata atgcttctta 1728781 tcattgtcgt aatacttttt gtaatatgtt tttttccaag tataatactc ttctttatat 1728841 tttttataat aacccaatta aattcctcct ttatgttatt cgaatttaat ttatgaagtt 1728901 taaatgatat ggtatggtca aatgaaataa gaatagtaaa aagaggctgt ttaaaacact 1728961 ttctgaaaaa caaaacggat agctgtttat gaaaataaga gcgagagaga gcactcaatc 1729021 actgtaaaat aatagtaaag tgtatagaga gattagtata cgtaaaaagg gactttctca 1729081 ttgaagaata tttgaacgtt atggttaaga ttcaagagct ctatgatgtg atttttcaca 1729141 ctgcttttga aggatttaga gttagacatc aaaaacaaac agcaaaaccg gctagaaaca 1729201 gatcatataa ggaatgaacc gctgccaaat atcataaaaa agttgttaat gatcaaatga 1729261 atgaaattag agagaattta ttttaaagaa agcccaattg cacatggaca aatgacaatt 1729321 gatattgagg taaaatacaa tgcattaaat cagaaaaagc tattggagga tttaatgtgt 1729381 ttagacaatt tccaatttgg tatacacaaa cacctgacta tttgaatttt tatgtaccgc 1729441 aatatcaaac catttcgtat aatcctcaac aatgttatca acggtgtatg taccaaactg 1729501 gcggtaacta tgagctatgt gacagactat gttatggaga aatacaggtg taaaagaggg 1729561 ggattaactc ctctttaaac acacagtgag tggaataaga tcctcacttt atctgcaagt 1729621 gcttagtatt tgcgataata ttgcattcgt aataaattat gcttagcaac tgaaaatgaa 1729681 agaaggatat gaatagtcat gacgcaattc gataaacaat acaattcaat tataaaggat 1729741 attatcaata atggaatctc agacgaagag tttgatgtaa gaaccaagtg ggactcagat 1729801 ggaacaccgg cacatactct aagtgtaatc agtaagcaaa tgagattcga caactcagag 1729861 gttccgattt taacgacaaa aaaggttgcc tggaaaacag ccattaaaga gttgctctgg 1729921 atttggcagc tgaaatctaa tgatgttaat gatttaaaca tgatgggcgt ccatatttgg 1729981 gatcagtgga aacaagaaga cggaaccatc ggacatgcat atggatttca gctggggaag 1730041 aaaaacagaa gtctaaatgg agaaaaagtg gatcaggtag actatcttct tcatcaattg 1730101 aagaacaatc catcttcacg cagacacatt acaatgctgt ggaatcctga tgaattagac 1730161 gcaatggcct taacgccatg tgtatacgag acacaatggt acgttaaaca tgggaaactc 1730221 caccttgagg taagagcacg gagcaatgat atggcattgg gaaatccatt caatgtattc 1730281 cagtataatg tgttgcagcg catgattgct caagtgactg gttatgagct tggtgaatat 1730341 atctttaaca ttggggattg ccatgtgtac acacgtcata tagacaattt gaaaattcaa 1730401 atggaaagag aacagtttga agcacctgaa ctatggatca atcctgaagt gaaagatttt 1730461 tatgacttta ccattgatga tttcaagtta atcaactata aacatgggga caagctttta 1730521 tttgaggtag cggtttaatg ctgccttttt attgtgcagt gaatagatag caggtatcct 1730581 aatttcatta agcaatctgg aagatgaata aaaattgaag gacaaacacg tataatacat 1730641 aaaaaagatt aactctacag ttaatctttt ttattcagaa gaaaatatcc taactttgaa 1730701 actaaataca aagtaaaagc aatcattaca gttctagata ttacaattcc atgaatagct 1730761 agatcatatc cagcaggtat caacgcattt gtattacaca taaaatatat agatattaga 1730821 agtgctacaa taactaaaat cattccaaaa agacttgttt tttcatattt cataccaatt 1730881 tccaccctta ttaaagttag gtttaaacaa aagagctgaa gaaacgaact atgaccagta 1730941 tgctccaagg aaaaccgcca gacaatgctg gcggcttttt gctgcttcgt ttatttatta 1731001 acagagatcg taacgttatt tcctgcaact gaaacctttg cgaaatcctg tgtatctacc 1731061 acaggagtga cggctttatt gtcgatagtg atgttgttaa aagaggtcga aaaggttgct 1731121 ttgatcgcat cacgctggct ttcatacgaa acagccgcgg tagcaagtgt tttccatttt 1731181 gaaatcgtgc cgatgttggt tccttgaatt tctgtgataa tccgtccggt gtagccgtca 1731241 ttgttcgttc cccaaagggt catgcgcgta ttgccgctta aatttttata gattgtcatt 1731301 tggactgtgc ttccagggcg gaagccttta ttgtatgtga atttgtcttt tccttcgatg 1731361 tacgtttctt catttttgga cccaaccttc atgaggggct tccagacgtt gtattgtttg 1731421 ctgtactgaa gcccgatatc ggcttcagtt ccgcttgttg ccctaaagcc agaataaata 1731481 tagggagtag agaccgagtc gttgtttttg acagtttcag gaagcacgat tttagctgta 1731541 aaaacggcgc ccgtactgtt caggtagaca cggccgccga ttccgttagg cagctcggat 1731601 gctgcttttg cgacttgagc gtctgccgcg ggtaaacctg gtatacctga tgaaagggtt 1731661 ccgaaaagaa ctgctgttcc tactgcacct gcaatcaata cttttttcac caaaattccc 1731721 ccttttgata gtggtttcgc catttattat accttatttt ggaactggat ttacgtatat 1731781 aaatcgacaa aatatttcat tttgaatgat gtaaggtcga aacgcttcgc caatctgaaa 1731841 gctatatacc tttatcagag gaaagaatga gatcacattc gttttaaccg atttgaaatt 1731901 ttcctcaaaa taaaagtaca aatgcttaaa gaaacgatta ttaaaagaat gcccgctatc 1731961 gtttccaagc ctgtaaaaaa gaggtgacgt ttcatcaatg tctgtccttg taaaatgata 1732021 aaagcacaga taccgactaa gaaaagaaaa caaatactta ggattgctaa cgctttacgt 1732081 gagtatgttt tcatttcatc tttaaaatac agcaatacga aaataaagca gataacattg 1732141 gctattgttc taatcacctc aaagcttttc atgacaactg atataaatag acaaagtaaa 1732201 atgagataaa atacgatgtt tctatacaaa aaacctctcc ttttatgtag gatcctcaaa 1732261 gagtttataa aagtttcttt gtaactgcaa taaattgaat gcgctcactt atgaactaac 1732321 taaactatgt actaaatatt cactattctt tttcagattc agtcaccaag gttttcatag 1732381 aaagggaagc ttcagaaata tacatatagt gcacaaacaa aaaagacccg gcaatagccg 1732441 ggggaaagta aaaacgagga gatgttaatg gcgtttagta gtgtttttta tgctttttat 1732501 actctacaac ataatcatag tcttttttat cgtgatcata atatttttta tcatagtcat 1732561 catatttttt gtcgtaatca cagtcataat cttttttatc atattcgtaa tacttcttat 1732621 aatacgtttt tttgaccgta taatactctt ctttgtattt tttgtaataa cccatatata 1732681 ctcctccttt atttttacta cgctttatta tacggcgagt agattttgcg gcttggacag 1732741 ttaaaatcat agaaggaaaa aagggctgtc caaatgatag aaaaagacag atgacacaaa 1732801 aacaaatcaa aataaagagc cgatttttca tcggcccaaa cgatttatcc tacatttgtt 1732861 tgtcttcttt gttttctgag tcattttttc tgatatcctg agtcagtccg cttgttgctt 1732921 gtttaaattc tgataaggct tttcctgctg cacggccaag cgccggcagt ttatcaggcc 1732981 caaatactaa aaaacccaca aacaaaataa cgagtatttt tgtgaagctt aattccatat 1733041 ccttttcccc ctgattgaag tacaaccttt taaacaaatt ataagagata gcagtacaaa 1733101 tgggaatgca tttattttga acattttaaa accagcacaa agacggattc ataaaacggc 1733161 tgctgctgaa tataatgtcc aatgccacct gcctaagaag caggaggcag gctggatcaa 1733221 ttatgtagct ctgccggaaa tgatacaaac gtagcggcta tcattgacat agaggagtgg 1733281 tgtagctgat gagattcact aaggtagttg gatttttgtc tgttttaggg ttggctgcgg 1733341 tttttccatt aacggcacaa gcagaaaaag ccggaactgc gggggctgga gagtgggata 1733401 agttggggac ttacacatat acttactcaa gtccgacggt atactcgacc ggaggagatt 1733461 ttagagtgtg cctttcagga agcactcctt tttctgtttc actgcactta tatgaggatg 1733521 atcccggtga caatcctgat gattatgtag gggcaaacta tttttcaccc ggagaatgcc 1733581 acacctttgg cagtattgga aaatttgtag atgggagcaa taacaaggcc gagttctttg 1733641 ttaccgatta ctctggtaaa tctaaaactg ttacgtttta tgattgatgg actcaaattg 1733701 tgaagtataa cccttggaaa aaaacaaaaa agagagatac ctctctcttt tttattcttc 1733761 gacagcctta cgaagccgtt catttacaat gccagtccag ccgccatcca tcttaccgcg 1733821 aacgacggag cttttctcgt ttgctttgcc gatcacttca ttcggctctt tccagccgct 1733881 gtgaataagg gtaaaccctg tcttttcccc caagtcttct aattgaaagg taacgaccca 1733941 tccttctgta tcccattcaa aagaaagttc agttggagct tgaacagcca aaactttaca 1734001 aggggacggc ccaaacggcg attgtaagtg aaattcttgt ccttctttga gctgaaagtc 1734061 attgggcata aaccacttgg caatgccttc tgaagtagag actgtctccc agactttctg 1734121 aatgggagcc tccagagtaa tgctttttgt aatatccggt aatgcatttt cgttgttttg 1734181 agccatttcg tttacctctt gacatatgat gttttttcaa ttcaatcata taataactaa 1734241 taagatcatg tccatagcgt gcattattta tgctagagct gctgttgaac agcgtgtcag 1734301 tcgccagtct gatctgtgaa tgggagaatt ctgcatgcgc gaaaaagaga gagaggtgta 1734361 tgttgtcatt tcgttcattc ttgtttgcag ccgcaactgt tatgtttgaa ctgggattcc 1734421 tgttcagcca atttattttg cgatttttgt tttaatagta aatgagccat tttctaaaac 1734481 aggaggtttt ttatgcttgg aaaaatcaaa gcagccattg ataatagtcc agggaagccg 1734541 gccagaattt tagttagtga aaaagcgttt cagcaattag aggaagaaat gcgctttgtt 1734601 tacgtttcca aaccgaaaac gataatgggg attcctgtgg aagtttcaga tcaggcagaa 1734661 agcttcaagc tggaatttta gttttcccag actgctaaaa ggctcatttt gtgttaatta 1734721 tgcaaaatgg tcaggttgat ttctttaaaa gcatgatgaa atgttcatca tgctttttta 1734781 ttgagaaaaa agacgaacat aaaaaatagg tatacgggaa aaataatcct attagagaga 1734841 ggggaactga cagatggata acatgatatc aacacttact gactggaatg tgtggtttca 1734901 agcgttagta gtatttctcg ttccatatgt aatctataaa gtgtttactt ggattcatgt 1734961 ataagaaggt gcaatgatga ggtggcggaa caatcagtac aaaacacaga agcagcataa 1735021 atcagattat tcgacagctg aaaagcagga tcaggatgtg ttaaccggta acatcggata 1735081 cgacttagaa catgtaaaaa gaaaaatagg acataacggg gacgttcatt tccgtgagct 1735141 tgaaatcact caattacatg tgaaagcggc attgatcttt gttgaaggac tgtctgatca 1735201 ggacttgatt aataaaggac tatcagtgtt agtcatgaat caacctaatc aggtaagcga 1735261 tgaaatttct caatccggca aaggtatttt aacttcgaaa cagataaaaa atcaaatcgt 1735321 atcaatcggt gatgtcatag attcagagaa aatcagtgat atcgtgttga atgttttcat 1735381 gggttcgaca gcgcttctca tcgatggaat accgcaggcc tttcttctgg gaactgtaaa 1735441 aaaacaaaat cgaagtatcg aggagccgct ttcagaagcg cttgtcagag ggccgcgcac 1735501 aggctttaca gaagagttga gtacgaatac agctcttttg agacagcaag gaaaaaatga 1735561 tcaattaaca ttgcagagat ttgaagtagg aacacgatta aaaaaggatt taattatcgc 1735621 ttatatgaat gacattgcag atccaaaagt agtcgaggaa gtaagaaaaa gagtgagagg 1735681 gattgagatc gatcatttgc cggagtcagg ctacgttgaa cagttaattg aggataatta 1735741 tttgagcccg ttcccgcaag tacagagtac agaacgtcct gatcgcgtca taagcggatt 1735801 aatggaagga agagtagcta ttctgcttga cggcactccg tttgctttga ttgttccagt 1735861 cactttcagc atgatgcttc aatcgcctga agattattat gaacggtggt tcccgagctc 1735921 gctcatcaga ttgctgaggt tcatcgcagc aatgataacg ttattcgcac ccgctttata 1735981 tatatcattt atttcttttc atcctgggtt aattccgacc aagctggcga tttcaatttc 1736041 cgggacgcgc caaggtgttc cgttcccatc tctgattgaa gccttattta tggaagtcgc 1736101 gattgaaatt ttaagagagg cggggcttcg tttgccaaaa ccaattggac ccgcaatagg 1736161 catagttggc ggattaatca tcggggaagc agctgtgcag gcggggattg tcagtccaat 1736221 catggtcatt gttgttgcgc tcacagcaat ttcttcattt gccatcccgc attatagcac 1736281 aggtatagca cttcggatgc ttcggtttgg cgcgatgttt tgtgcggcgg tgtttggatt 1736341 gtttggagtc attatgtatt atctgctgct aagcagccat gtcgtaaagc taaagagctt 1736401 tggtgtgcca tacgcaagtc cggcagtgcc ctatcactta aaagattgga aagactttgt 1736461 tatcagaatg cctcttttag tcatgaagcg ccggcctaaa atgatgaata cagataatac 1736521 aaaacgggtg aagtgatgaa ctcgacagga tggtgataaa gtctcatgtt cagcccaacc 1736581 agtaaaatca caaccgctca ggcaacgatt atcatcatta attatatgct tgctgccgga 1736641 gttcttacgc tccctcggac agtaacagaa caaacacaat ctcctgatgg atggatttca 1736701 gttttattag gcggggtcct agcggtaata gccgggatga ttatagctaa attaagccag 1736761 cagtatccta aggagacctt ttatgaatac tcccgacata ttgtaggaaa atggctcggg 1736821 catctgatca gtattgtttt tattacttat tttctggcac tcggtgcatt tgaagtcaga 1736881 gtcatgtccg aaatcgtgga tttttttctc ctcgaaggga caccttcttg ggccatcatt 1736941 atgacagttc tttggattgg gctttattca attacacaag gcctagatcc gattgcacgg 1737001 ctttttgaaa tgatttttcc gattacggtc atcatctttt taacgatagc cctcatgagt 1737061 ttaggcatat ttgagatcaa caatttgcgc cctgtattag gtgatggaat catgccggtt 1737121 cttagaggtg taaagacaac gaacctttca tttacatgtt cagaaattat gttcatttta 1737181 gtagcattta tgaaaaagcc gaaaaatgcg gtgaaagcag ttgtgatcgg gacaggcgtt 1737241 gtgaccagtt tttatatgat tacgatgatt atggtcatcg gtgcactatc agttgaggga 1737301 gttgtgacga gaacatggcc ggggcttgac ctgatgagaa gttttgaaat acctggttta 1737361 atatttgaac ggtttgaatc atttctgctt gtgatttgga ttatgcagct ttttgccacg 1737421 tttattatca ctttttatgc agcttccctg ggagtctcac aagtttttaa aaagaaaccc 1737481 ctttcatgta tgtttgggct gcttcctgtt atatatatcc tctcttgcat gccgaaaaat 1737541 gaaaatgacg tctttatatt gggcgatacg gtcagtcata tcgctttgta tatatttggc 1737601 gctttgccga ttttgctgtt agtcatttcg aaatggagga aaagaggtga aaagtaaact 1737661 aaaacgtcaa ttgcctgcta tggtcatagt atgtctgctg atgatttgcg taacaggatg 1737721 ctggagcagt cgggaaatag aagatctggg tctcacattc gctatcgcaa ttgataaagg 1737781 aaaagaaacg aacactgaaa aagagttaaa agaagagggc gggagctatc cgaaaaaaga 1737841 caacattacg ctgacctatc aatttgttaa tgaaaaagcg gcaggcgcgg gcacaagcgg 1737901 gggaggcggt agcggacaag gagcgcaaaa agcgtacatt aatataagtg aaacagggga 1737961 ttcattacag cagatcggaa gtgaggttgc attaagacgg gaccgagaag tgtttagccc 1738021 gcatttaaaa gttgttgtca tgagtgaaga tgtgctgcac acatttccta tcgacgaaat 1738081 gctggatcaa ttttttcgtg ataatgaaat caggctgagc tgtcttgttt tatctgctaa 1738141 aggggaagca agagacgctc tccagctgaa agagaacgga gaaattccgg catttcggct 1738201 gattggatta ggtgaaaatg aacataaagt ttccagaatt cttcccccta tgacactcgc 1738261 gaaactaatt ggaaaactgc attctggcag cagcttttta ctgcaaaatg tggttgcggc 1738321 gaatggagcg gtcaagtatt ccggagcagc tgtaatcaac ggaaaatcga aaaaaatgat 1738381 aggcacctta aatgaatatg aaactgaggg gattacatgg attagaggag aagggaaagg 1738441 cggagttgtc aaaagtcatg ataaaaagag ccaacagacg ttagcgtacg atatcaataa 1738501 aatcaaaagc agaattcagc caatcgtaaa agggaaagat atttcattcc atgtcgatat 1738561 tgaatcagaa ggcgatttgg ttgaaaactg gaacacaaaa gaggcgttgg acacccagtt 1738621 tatagatcgt ctcgaaacga ctattgaaaa cgaggtaaag aaaatagttg gtcaggtatt 1738681 aaaaaaaatt cagcatgatt ataaagcaga tgttgcgggt tttgatgaat cttttagact 1738741 tacatatcct cacttatgga aaagggtgaa aaataactgg gatgacacct tcagtaaagc 1738801 cgacatcaca tacagtgtga acgtcacaat tactcatttc ggcacggtta aaactcagta 1738861 atgaatccca aggaagagaa ggaaacctct cttctctttt ttatgcattt attaggataa 1738921 agatactttt tttggagaga tatacacttt tcaaatcgac caatatgcta atataggaat 1738981 tgcttgaaat agaagggaga aggggctgtg aggcagaaac cgatttatgt agaaatcgaa 1739041 atgaaatctg atctggatac actctgggaa tatacacaaa acccatcact gcataaggaa 1739101 tgggatctcc ggttttcaaa tattacgtat ttgaatagtc agccatgcga aaaacagaag 1739161 tttctttacg aaacaagggt aggctttgga ttaaaggtgt caggtacagg agaaaccgtc 1739221 ggtgttttca acaaatgttc atctgaaagg tcttcttcac tggcttttgg ctctgatcat 1739281 ccattatctc tgattcggca tggaagcggc tactggaagt atatacagag agaaaatggg 1739341 aaaatgacgt ttttaacaca gtaccaatac aaaacagcct acggactgct gggaagatgg 1739401 attgatcgtt tattatttcg gccgctgctt ggctgggcga ctgcctggag ctttgatgca 1739461 ttaaggcttt gggtagagca aaataaacat ccgaagcgct tcattcgatc tgctatcatc 1739521 tatgtgttca tgtgtctgtt tttcagcctg ttttggttct atcaaggctt tgcaggtgtt 1739581 aagacaagca tattgacagg aacagcggag ataggcttag ctattttgtg gctgcttcct 1739641 ttaaaaagaa aatggatcat tcatggtgtc caggcttgta tttttgctgg gtttgcttgt 1739701 ctaggttccg aaatattcat gtgggttcta ttgagtgtgt tttccgctgc aagcggcgct 1739761 cttagcctgc agctccccag tgccaggcgc acaaaacgaa agagaaagaa gtgacattgt 1739821 gagttcgatt tatgaaaaat caattattaa ctatcatttg ctgcatccca agctgcagaa 1739881 acggtaccaa ttagacgggt ctcatacatt cagcgggacg ggaacgatgt cagaaataag 1739941 cggaggctct tttctggtta gaatgctgtt aaagctgggt gtttttttca gatgcttctt 1740001 ttcagaaaga ggcaaagaca ttccatttac aatacaaaat agaacttgtc ttttgaaatc 1740061 gcaacataca ggaatagaat ggaatcgtac atttttcttt aaaggcaaaa aacgtttctt 1740121 tgatgcgtta atgatatatg acgagaaaga aaatagaata cttgatttct tcggcaaacc 1740181 tcatctgctg ctgtctgttt tgacgttcga ggcatctctt gacggctctc ttacgatcac 1740241 atcgggaaag caatggctat tgatatgcgg aaaaagaatc ccgctgccga aatggctgac 1740301 cggtacatcc gaagtttgcg aaacgtttga tgaaaaaaag aattgtttca ccattgaagt 1740361 gcatgtgcaa aatacaattc ttggcactct tttcttttat aagggaacgt ttcaggagga 1740421 agagagagaa tcatgaaacg aaatggcata gtcagtgcgc tttgttttat tggatttctt 1740481 gcagcagaag caccggatat ttcagtggca gaggcactcg ttttgttatc cattctattt 1740541 ttcgtgccgg gaatttttcc ttttgttttt cgtcaatctc cggttcgtgc tgctcagttt 1740601 atggaaaacg ggctaatcca gtgctatcct gtagccgcat tctttgcggt gctggctcta 1740661 gtgacggagg ttgggggttt cgcacttatc tggtggatgt acacagtttt taatgcattg 1740721 tatgcgatcc tccgcctttg ggaaacaaag atacatagaa tcgaagagac atcagttttg 1740781 ttcggtctta tttatttggc gggaggagga ttttggtttt ttgcttatgc tgcccatttg 1740841 cagatcatgc aatttggccc tctcatcatt ttgctgactg ctgtccactt tcactattct 1740901 gcttttctga tcccgatctt caacggttta ctcggcagaa ccattagaaa acatcggatg 1740961 ttgtacagtt ggataacatg ggtgattttg ctttcgcccc ttcttatcgc actgggcatc 1741021 acatattcaa aaacacttga tgtcattgcg gttagcattt atatggcggc gatttatctt 1741081 catgcatttt tggtgttcac ggcagctttt cgcaccaaga cggggacatt tcttattcgg 1741141 ctttcttccg ctgttttaat gataacgatt gctttctcga tgatttattc atttggtgtc 1741201 tttcggcaag aagttacatt gaccatcaat cagatgattt ggattcacgg ttttgtcaac 1741261 gcgtttggtg ttatcttgcc cgctctcata gggtggagaa tagaggatgc gaaacctttt 1741321 gatgcagaca gtgtaaagac attcagccgt atctacggaa aaagaaagat tggagaagaa 1741381 tttttagcta acattcaagc tgaaaataac gctcggtaca gcggacttgt ggatgatatg 1741441 ggcagcctgc gttcaaaaga tttttcacca gaaaaactgg cgccgctcat tctttcgttt 1741501 tatgaacaaa ccatcgaata caatattaaa gcaaaagtaa catggagcac gtggtttcgg 1741561 ccgcttgcaa ttatttacga atggttcagc agaagaatcg gccaaataca tctttcgacg 1741621 aaccctgact ggtataggat gtacagcaag ataaaaggtg ttcattcgaa aaaagacgga 1741681 agggaaagag tacgtgcctg gattagaaca aatgaaaaaa acgaaaccat ttttaccgct 1741741 ctttattcag tgtatcgttc aaatggagag gggtatatga atatttcttt accgcttcca 1741801 ttcagcagca tgacaggtat tttaaaacca tatcatcatc aggagaagct ggttttaaca 1741861 agcaggcgga gaaaaagcag agcgggggat gaggggattt atctgcaaac aagagcggga 1741921 acttgtccgc ttcctttatc tgaaaccttt ctgatagaag ctgtacatga caacaaatta 1741981 accgctgttc atcatatgtg gctgtttgga ataaaatttc taactgttca ttacagcatt 1742041 acacatatta accagcctat tgaaagaacc taacacaaag aagaagcttc gtctgccagt 1742101 tgtaatgaga tgaactgttt taaaattctg caccgcatca agacaggaaa ggaagggttt 1742161 atggtgtttt atatcagttt atttctgatt ctttggctgg ctgctgggtt tgcagtggga 1742221 atgaaacaag tgtatgtcga tcagctgttt gataaagctg tgatcgaaag actggaaaaa 1742281 gaagcgaatg atcatggaca tgctgaccgg atgatcaaac agcgcgtcct ttatattgca 1742341 gcagtgacag taagcgggtt tatttctgtt tattatgaaa tgaaaacaat cccgcaaagg 1742401 cgaaacataa gaaaaattga aaaaaacatc atgaaattaa atcaagcaaa aaaacgaaga 1742461 atgaagagaa aataaaaagt gcacaggcca aagggcaggt gcatttttgt tttgtatgga 1742521 aaatggggga ggtggtgcca gcttactttt cataaattca aaaatgagaa gaacagcgcc 1742581 cgggctaatg gtatataata ttgtgaattt aacaaaaatt taacaaggag gacgagagaa 1742641 ttcgtgctaa agcctcaaag agacctacat tctgttgatt tggacttaga ggcggagtag 1742701 atgaaaccgg ccaaagtatc cctgctccgc cgtttgctcc attccttgaa gcatgttgat 1742761 tgtaacatag ccaaacgttt tccatcaact attaaaattg taaaattatt gatgattttt 1742821 atggtgttta ctccgatttc ttcaatttat gctgaagatg tatatcagaa ttttgaggaa 1742881 ttaaaaaaca atgaagatcc ttctgattat ggcgttgtta cgaaagaaac cggaagccct 1742941 gttcttgttt tagctattca cggaggaggt attgaaggcg ggacaagtga agtagcgaga 1743001 gagctcagca aagagtactc gatgtattta tttgaaggct taaaatcggc aggaaactca 1743061 gtcctgcaca ttacgagcac acactttgat gaacctcggg cccttaaaat gacgggaaat 1743121 catgaatatg tcatttcatt acacgggtac gcagaagaag atcagcagat cgaagtcggc 1743181 ggtacagatc gcgtaagagc ggcagattta gttgagaaat tgcagcatgc cggttttcct 1743241 gctgtattgc tcaatatgga ccatccgcat gcgggcgtta gtccgaataa cattgcaaat 1743301 aaatcaaaaa caggtttaag tattcagata gaaatgagca cagggtttcg aaagtctttg 1743361 ttcggcatct tttctttaaa aagcagagct gttactcaaa atgagaggtt ttatgagttt 1743421 acagaagtga tgttccgttt tctcaaaaat agctactgaa aaataggagg cgataagaca 1743481 gcctcctatt ccttatgctt ctctttcgtt tcgggaaaca gctcgtccgc ggcttccgtt 1743541 tgatactgca acgtgttatc tctcgctgac agttcatttc ggaaattttc atcaagcaca 1743601 tttttcagta aataccgatg aaaaaagtat tcaaaaacag taagacaggc agcggaaagg 1743661 agagccgctc caaatggtga gaaatcgttt cttgtttggg ttaaaacaaa tacccaaaga 1743721 ataacgaatg aaaggccaaa gtcagccaat gaagctgtaa tattgtttgt tctgggtaag 1743781 acgagcatgt caccagaaag ataggaaaca aaacctaaga aaagtgcaat aaacatcaca 1743841 cttaaaaagg atgcgtgata gactctgtcc aaaatcacat ataaaagggc gagagtgaaa 1743901 gcaatctttg aagcaagcgc aatgatatgt ttcatttgac cacctaaatt gttatttttt 1743961 gaagaaaatt cttgggcgta aacaaatgat aaataatgca attcaaaacc attcataatg 1744021 gtcatgttac tattttaaac agtccgtttt tgtttacact ggtatttttt tcagctgtat 1744081 gaaactttct tatgaaaaaa gtcgtatatg tggatgatca gctttcaagg ggggaatgat 1744141 ttgtggagat aaaaggaatc aatcacttgc tattttcagt ttcgcatttg gatacatcga 1744201 ttgattttta tcaaaaagtg tttggtgcaa agcttttggt aaagggaaga acaactgcat 1744261 attttgatat gaacggcatc tggctagcgc ttaatgaaga accagacatc ccgagaaatg 1744321 acattaagct ttcttatacc catattgctt ttacaattga agatcatgaa tttgaggaga 1744381 tgtcagctaa attaaaaaga cttcatgtca atattctgcc tggcagagaa cgagatgaac 1744441 gcgatcgaaa atcaatttat tttaccgacc ctgacggcca caaatttgaa tttcataccg 1744501 gaacccttca agacaggctt cgatattaca aacaagaaaa aacgcatatg cacttttatg 1744561 atgaaacggc cttttgatag cacaaccata tttcatataa ggttaaattt aaagaagggt 1744621 gttggtggag actttatgtt tggggaaggt ttctacccga cttgttcaac gatgccatat 1744681 cttttgaact gcacaagtga ttgggtgaag gtgaaattga aatacacatt acattacatt 1744741 ttatatgaag aaagcgagct gttttatcaa atgttgaact aattaaacta tgtactaaat 1744801 tttcagtata tttcaattgc tttgcccctt aataaatata aaaccgcatc cttccacgac 1744861 ctaaaaaatg aaacgttttt aagaagatgg cgtctaatat tctaaatgtt catattttga 1744921 taaaagtttc ctaaaggaaa gaaaatttct tgacttcaac aatcttttgg tggataatta 1744981 tggtgtaaac atgatgttct ttttcctcct attcgggctc gcacccaaaa gtcagggcga 1745041 gcctgctttt tttgaacaac aaaccccctc tccgtaaagg aagagggggt tattttatgc 1745101 atctgataga tcaatagatt aatggacggt tctgaacacg ccaatcactt tccctagaat 1745161 gctgacattc tgcaaaatga taggttccat cgttgggttc tcaggctgca agcgaatgtg 1745221 ggtatcctct ttatagaatc gttttacagt tgcttcatca tcttctgtca tcgcaactac 1745281 aatttcccca ttgttcgctg tgttttgctg tttaacgatg acatagtcct tatcgagaat 1745341 accagcatct atcatactgt ctcccataat ctccagcata aatacatgct cgtctggagg 1745401 aaccatgcgg tcagggagcg gaaaatattc ttcaatattt tctactgctg taataggaga 1745461 tcccgccgtg actttcccga tgaccggtac attaacgacc tggctttgcg gaatgtctac 1745521 ttcttcatca agaatttcta ttgctcttgg ttttgtcgga tctcgtctga tcagcccttt 1745581 tgtttccaaa cgggccaaat ggccgtggac agtagaactg gacgcaagcc cgacagcctc 1745641 tccgatctct ctcacggaag gcggatatcc ttttgattta acctctgctt taataaaacg 1745701 gaggatatca agttgccttt ttgatagctt cgtcattttt cgcacctcaa aacgtcgatt 1745761 ttaagaagat tatagcatga ttttccttac agtacaaaca taggttcgaa aaaacaattg 1745821 acagaaacgt ttgttcgtat atactgaaat tataaaaatg cgaacaaaca ttcctgttgg 1745881 aggttatgat catgagtaaa gaatctatta tttttgtcgg tctgtttaca gtgattttga 1745941 gcgcggttat ccttatgctg tcatatacaa gcagcggcca agagcttaat cagtatgtta 1746001 aaatagaagt ccagcaaggc gacacactct ggtcaattgc tgatcaggta gccgatacaa 1746061 aaaagataaa caaaaatgat tttattgaat gggtagctga taaaaatcaa cttcaaacct 1746121 ctgatatcca gccgggtgat gagttagtga tcccattgaa aaagaagcat caggatgcat 1746181 atgaattagc aactgtaaga tagagaggaa agagagataa aatgaaagca ctcatttatg 1746241 cccgtgtaag cacaaataaa gaacagcagg aaacgtcatt aaagcggcag gaggaggagc 1746301 ttacggccat tgcagcggag aacggcatgg aagtggtcaa agtgatttca gaaaaagcca 1746361 gcggatatga aatggatcgg gatggtgtat ttgagctgct cgatgagatt aagaacgctg 1746421 atattgatgt cattttggtt caggatgaga caaggctcgg acggggaaac gcaaaaatcg 1746481 cactgcttca ttgtatttat agagaaggtg tgaaagtcta tacaacggct catagaggtg 1746541 aactggagtt atcggaggct gactcaatgg tcttggaaat cgtcagcatt gtggaagagt 1746601 atcagcgaaa gattcacaac atgaaaatca gacggggaat gaaacgtgca gtaaaaaacg 1746661 gttttaaacc gcaaaaaaac ttaaaaaacc aacatgggaa cagtggaaaa gaaaaaatag 1746721 aggtgccaat ctcagagatc gtccgcctga gagcgaataa actgacgttt gctgaaatcg 1746781 cggctaccct aagagggttt ggctatgatg tctctaaagc aaccgttcac cggcgttttc 1746841 aggaatacat agagaatgaa gagactgcag agtgaatcag ttgtaaaact ttttttgatc 1746901 tagtactata tagacaaaat gcaataaagg agtttaacat gatttcaaac gcgaaaattg 1746961 ccagaattaa tgaacttgct gccaaagcta aagctggcgt tattacagaa gaagaaaaag 1747021 ccgaacagca aaagctccgt caagagtact tgaaaggttt tcgttcttct atgaagaaca 1747081 cgttaaaaag tgtgaaaatc attgacccag aaggcaatga tgttacacca gaaaagctaa 1747141 aaagagaaca aagaaataac aaacttcact aatataagag gaatacggca atatcgtatt 1747201 cctcttttgc atatactata atcaaaactc ttatgtgaca aaattcaaca agtttctctc 1747261 aaatttaagc tgaaacagtt gagaaaaagt cgtcagacat ttatgatgta agggtacaac 1747321 acataaggaa ggggattttt atggatacaa ttgaaaagaa atcagttgct accattcgca 1747381 cactgtcaat agacgctatt gaaaaagcaa attctggtca cccagggatg ccgatgggag 1747441 ccgctccaat ggcatacacg ctgtggacaa aatttatgaa cgtaagtccg gcaaaccctg 1747501 gctggtttaa ccgtgaccgt tttgttttat ctgctggaca cgggtcagca ctattataca 1747561 gcatgcttca tttaagcggg tttgatctta gtattgaaga tcttaaggga ttccgccagt 1747621 ggggcagcaa aacaccagga catccggaat tcggacatac tgccggtgtt gatgctacaa 1747681 caggtccgct tggccaagga attgccatgg cagtcggtat ggcaattgct gaacgccatt 1747741 tagcggaaac atacaaccgc gattcattta acgtagtcga tcattataca tacagtattt 1747801 gcggtgatgg tgatttaatg gaaggtattt cttctgaagc cgcttcactc gcaggccatc 1747861 ttcagcttgg ccgtctgatc gtactatacg attctaatga catctctctt gatggagacc 1747921 tcgaccgttc attctctgaa aacgtgaaac agcgttttga agcaatgaat tgggaagttc 1747981 tttatgttga ggatggaaac aatattgaag aattaacagc ggctatcgaa aaagcacgcc 1748041 aaaatgaaaa gaaacctaca ttaattgaag tgaaaacgac aatcggattc ggttcaccta 1748101 accgtgccgg tacatccggt gttcacggtg cgccgcttgg taaagaagaa agcaaattaa 1748161 caaaagaagc ttacgcgtgg acatatgaag aagacttcta cgttccgtca gaagtttatg 1748221 agcatttcgc tgtagctgtt aaagaatcag gtgagaaaaa agaacaagaa tggaatgctc 1748281 aattcgctaa atataaagaa gtttatcctg aacttgctga acagcttgaa ctggcaatca 1748341 aaggagagct tccgaaggac tgggatcaag aggttcctgt gtatgaaaaa ggaagcagtt 1748401 tggcatcccg tgcatcttcc ggtgaagttc tcaacggact tgcgaaaaaa attcctttct 1748461 ttgtcggagg ttctgctgac ctagcgggat cgaacaaaac gactattaaa aatgccggtg 1748521 attttacagc ggttgattac tcaggcaaaa acttctggtt tggtgtacgt gaatttgcga 1748581 tgggtgcggc cttaaacggt atggcgcttc atggcggtct tcgtgtattc ggcggaactt 1748641 tctttgtctt ctctgattac ctgcgtcctg cgattcgcct tgcagcgtta atgggccttc 1748701 ctgtgacata tgtcttcaca catgacagta ttgcggttgg tgaagacggt ccgacgcacg 1748761 agcctgttga acagcttgct tcactccgtg cgatgcctaa cctttctttg atccgtccag 1748821 cagacggcaa tgagacagca gcagcatgga agcttgcagt gcaaagcact gaccacccaa 1748881 cagcgctagt gcttacacgt caaaaccttc ctaccatcga tcaaacatct gaagaagcat 1748941 tggcaggagt agaaaaaggt gcatatgtcg tttctaaatc taaaaacgaa acacctgacg 1749001 ctcttctcat cgcttccgga tcagaggtag gtcttgcaat tgaagcgcag gctgaattgg 1749061 caaaagaaaa tatcgatgtt tctgttgtca gcatgccttc aatggaccgt tttgagaaac 1749121 aatctgatga atacaaaaac gaagtccttc ctgcagatgt gaaaaaacgt cttgcaattg 1749181 aaatgggctc atcatttgga tggggcaaat acacggggct tgaaggtgac gttctcggca 1749241 tagaccgatt cggtgcatct gctcctggtg aaaccatcat taacgaatac ggcttctcag 1749301 ttccgaacgt agtgaatcga gttaaggcat taatcaataa gtaagctttt gaaagaggat 1749361 gagtcaaatc atcctctttt tcttgtttat ccgacaaaaa tagtattggc tgtttaacag 1749421 taatagacaa ttctttcttt tcttcttttg tataatagag agcaaatgaa atgctgctgg 1749481 aaaaggggat gaaaagatgg aacgtcacta ctatacgtac ctgatcaaag aggaatttgc 1749541 caatcactat ttcggccggg aatcggttat gtttgagctg tttcaagact atcattggac 1749601 aagccttgaa aagcagcagt atgaaatgac agagaaacag attcaatata ttacacaacc 1749661 aatcccgatt ttacatatgc atcagcggtt aaaaatgaat ttaaacaaga cggattacag 1749721 gcagctggat tatatttata gaatagcttt gccgaaagca aaaggccacg cgacgtttat 1749781 gatgaaggag cacatgatag aaattgtggc ttcgggagat tacgaggcag aaacgatatt 1749841 ctttgaagtg ttaagaaaag taagcccttg ctttttagca atggatttca attcgaagcg 1749901 ttacggatgg ctaaatccgg tgaaagaaag aaattttgtc taaaaccgaa gaaaaagaga 1749961 tgtaaatgtt gtataatagc ttttggttta gtacacttta aactagacaa catgaaggag 1750021 gaaataaaat gactttatgg gttggcatcc tagtgggcgt tgttgcattg ctcataggtg 1750081 ttgcactcgg gttttttatt gctcgtaaat atatgatgag ctacctgaaa aagaatccgc 1750141 ctattaatga acaaatgtta cgcatgatga tgatgcaaat gggaatgaaa ccttctcaaa 1750201 agaaaatcaa tcaaatgatg aaagccatga ataatcaaac gaaataatac gtaaagatta 1750261 tgatatagag aaacatggtt ataaaataaa aaacccttat acgggttttt tattttgcaa 1750321 tcattcatca cccgctactg ctcgaaggcg ctgcttttga tattgtatga gaagatggtc 1750381 aagctcctga ctgagctcta tcgtaatatg agatgtcatt ccgttcgcca tgacaatttg 1750441 cagcagctct gctctttttt tttcaatttc ttttaataga tgctctctaa tcacagggat 1750501 gtatcctttc atacattaga tcttcaaagt gaatgtttat attatatcca tatttatact 1750561 aattttcaaa tgagaaggag tataatgtct caatgtcaaa ttaaattata taagtttttt 1750621 ctgaaaatag aaatccttca agtgaaagtg ttaaaaaaat gaaatgattt tgtcataact 1750681 tgaaggaatg tcaaatcatg aagggatgat gacatgggag acgtgaatta ttttttgaca 1750741 ttcggagcgg ggtttttatc ctttatttcg ccttgctgcc tgccgcttta cccagctttt 1750801 ttgtcatata ttacaggggt cagcatggac gatgtaaaaa ctgaaaagct gctgctgcag 1750861 aaaagaagct tgtttcatac tttgtgtttt ttgcttggct tttcagtcat ttttattgct 1750921 ttaggctatg gaacatcttt tattggcagc ctgtttaggg attatcacga tgcgattcgg 1750981 caaattggcg cgttgcttat tattttgttc ggtttcatta cactcggtgt gttccggcct 1751041 gaggctatga tgaaagagcg gagaatccat tttaagcata aaccaagcgg gtttttaggg 1751101 tcggtcttaa tcggaatggc atttgcagct ggatggacac catgtaccgg tccgatatta 1751161 gctgctgtta tcacacttgc aggcaccaat ccgggctcag cggtgccata catgatgtta 1751221 tatgtactcg gttttgcggt accgtttctt ttattgtctt tttttatcac aaagctgaag 1751281 tggataagga agaaccagct tttcattatg aaagctggtg gcgttttgat gattgtgatt 1751341 ggtgtgctgt tattctttaa ttggatgagc ctgatcatta ttttgctgtc agatcttttt 1751401 ggaggcttta ctggtttttg acggtaaatt actttcgtac tactactaat ccttttgttt 1751461 ttggtacaat aagactatta tctgtggaaa tcgattgttg gaggggaata tgacaagagt 1751521 tttagttgta gacgacgcca agttcatgag agtgaaaatc agagagatct tggaagaggc 1751581 aaattacata atcgcaggcg aagcggcgga cggtgaacaa gcagctgacc tgtataaaaa 1751641 actgcgcccg gaccttgtga caatggatat tacaatgccg gtgaaaaacg gcataaaagc 1751701 gcttcgtgat atcttaacct ttgatcctaa agcgaaggtc atcatgtgca ccgccatgcg 1751761 ccagcaaaga attgtaacgg aagcaattga gctgggggca aaggatttta ttgttaagcc 1751821 gtttgaggaa acaaaagtgc tggaagctgt aagccgcgtt atgggacatt aaagtcattt 1751881 cttttcaaaa tggttttttt tattgttttg gagtatagta tatagtatca acactccgag 1751941 aaacaaagga atgataagta tgatgattat agtttcatca attattgctg tgttaatggc 1752001 tgtagctgtg atggtggtca gaataaagtc ctctgacaag cctgtttcac caaaaaaaat 1752061 cattcttccg ccgattttta tgagtacggg agcgttaatg tttttatttc cggtattttg 1752121 ggtaactgga gcagagtttt tggaagcatt cactttaggt gtgattttct ctatttttct 1752181 aatcaaaact tctaagttcg aaattaaaaa taatgaaatt tacatgaaac gctctaaagc 1752241 atttgttttt atattagtcg gtcttttggt gatcagaatc gtgatgaaat cgatcttgag 1752301 cacatcaatt gattatggtg cactgagcgg aatgttttgg attctggctt tcggtatgat 1752361 tgtgccttgg agaatcgcca tgtatttatc atatcgaaaa cttcataacg agctgcagtc 1752421 atctaatatt caaatgaatt aaaaaacctt tcctcttgtc aggaaaggtt ttttatttga 1752481 gaagggtctg ataaggttcc aaatcgattt ttttgtcccg cagatgcctt tttaagaagg 1752541 tatggtctct tttaggagtt gcgagaatat agcctttgat cataagttgc tgatcaatct 1752601 ttgctacctt ttcttttaat gcaagctcac cgattttgcc tgcgatttta gcttttgctg 1752661 catctctgaa cagctctggc acgggcgcag tcaattcatc tagaaactgt ttgttttcat 1752721 cgttccataa atgtctgctg ttttcaatat agtaatcctg ccaatcaagc tctgatctgc 1752781 cgtcctcttt tggtaaacgc tttaaaaact ttcgaaacat gaaaaaaccg ccgattgata 1752841 ataagactac catcatgatt acccaaaaca gaataaacca taaaaaccat ccttccagca 1752901 tcaatcattc ccccttattc taaccatatt gtatacgaag agagattaga agaacacagt 1752961 aaaaaaagaa tagaaaaaag tgatagacgt ctagtcaaaa gagatagtag atcatattct 1753021 attgtatagt gaatctgcta tttggccatg ggagagtcac tagagggtat ttgacgataa 1753081 atggacggaa aaaaagtcac tttcataata ggggatgaaa gtgacttttt atgtttagct 1753141 gagaggaaat tgaagagaaa aagaagagcc atcttctgtt tctttattga cggcgactgt 1753201 gagtatttga ttttcgcatt cgacttgaat gtttttgtca ttaaaataaa aaggaagcat 1753261 catttgtttt tcaaaagtct gtcctgacga tttgacagtt aagatgaact cgcatccaga 1753321 aagggtaact gttacttgtg taggctgtaa aaaagtcaga tccgcttcta taatatactg 1753381 ctgacttgtt tcatataaat caataggcaa tgtttcgtcg taccaggcga aggggtcttc 1753441 aaaaaattgc cgaagccatt catccatact atcgaaatca ttcgcatcgt tgcgttttga 1753501 atggttcatg gaagcattcc tccacatatc aaccttgctt tacatcatat gcggtggatt 1753561 ataaatgggt gaacgcataa aaaaacagac actaaggtct gcttttctta catatcatgg 1753621 cttgagttgt gcttttgtct tgtatggttt cggtttttta cttttttgct tccgcttaga 1753681 ggctcgggtt ggccgggatt gtgtccttta ggggcgtttt tatgcatatc tttacttgta 1753741 ttcttattgg tcataaaatg agaacctcct taaaagagtt cggtgttatt gattggtttt 1753801 tctttttttg ttattttggc gttctgcttc agtcagtaca agctggtcgt tttcaatata 1753861 gccggcgcct ttgccttggc tttttgcgtc attcattccg ttaatgacgt gattcgcttt 1753921 tcttttgacc atcattatca cctcaatcat aatatggctt cttttattgt gttatatgag 1753981 agagcgtaaa cagtaaaaat taccggtaca tttttctcat aagtcgaact tattgtattt 1754041 aataaaaaca ttgatattta cttatgtatg attttgtttt aatatgaaat tgtgagaaaa 1754101 ttgtgatgga atgtaatgtt catctgagaa tgatctgatc tgaaggggga ttttggagaa 1754161 tggcaaacga gcaaaaaact gcagcaaaag acgttttcca agcgagaaaa acgtttacta 1754221 caaatgggaa aacatatcat tactactctt taaaagcgtt agaagattca ggtataggaa 1754281 aggtttcgaa gcttccttat tccatcaaag ttcttttaga atcagtattg cgtcaagttg 1754341 acggcttcgt tatcaaaaaa gaacacgtgg aaaatttggc aaaatgggga actgccgaat 1754401 taaaggatat cgacgttccg ttcaaaccgt ctcgtgttat tttacaagac ttcacagggg 1754461 ttccggcagt agtagatctg gcttcactgc gtaaagcaat ggcagctgtc ggcggagatc 1754521 ctgataaaat caaccctgaa attcctgttg atctcgttat cgatcactct gtacaggtag 1754581 ataaagcggg tacagaagat gcattagcag taaatatgga cttggaattc gaaagaaatg 1754641 cagagcgcta caaattttta agctgggcaa agaaagcgtt taacaattat caggcagtac 1754701 cgcctgcaac aggtattgtg caccaggtca accttgagtt cttggcaagt gttgtccatg 1754761 ccattgaaga agacggcgag cttgtaacgt atcctgatac gcttgtcgga acagactcac 1754821 acacaacaat gattaacggt atcggtgttc tcggctgggg tgtcggtgga attgaagctg 1754881 aagcgggaat gcttggacag ccttcttact tcccagttcc agaggtaatc ggcgcgaaac 1754941 ttgtcggcaa gcttccaaac ggaacaacag ctactgactt ggcgttaaaa gtaacacaag 1755001 tgctgcgtga aaaaggcgtt gtcggtaaat ttgttgaatt cttcggaccg ggaattgctg 1755061 aactgccgct tgcagatcgc gcaacaattg cgaatatggc tccggaatac ggtgctacat 1755121 gcggattctt cccagtagat gaagaagcgc ttaactacct gcgcctgact ggccgtgatc 1755181 ctgaacatat tgatgttgtt gaagcatact gcagaagcaa tggcttgttc tacactccag 1755241 atgcggaaga ccctcaattt actgatgtgg ttgaaattga cctgtctcaa attgaagcaa 1755301 acttatcggg tccaaagcgt cctcaggatt tgatcccgct atctgctatg caggaaacgt 1755361 ttaaaaagca attagtcagc cctgcaggta accaaggatt cggtttaaat gctgaggaag 1755421 aaaataaaga aattaagttt aaactcctta acggcgaaga aacagttatg aaaacgggtg 1755481 cgatcgccat tgctgcgatt acaagctgta caaatacatc aaacccatac gtgctgatcg 1755541 gcgccggact ggtagcgaaa aaagcggttg agttagggct taaggtgcct aattacgtga 1755601 aaacgtcact tgcaccgggt tctaaagttg ttacaggata tcttgtgaat tcaggccttc 1755661 ttccatacat gaaagagctt ggctttaacc tcgttgggta cggctgtaca acatgtatcg 1755721 ggaactcagg tccgctttca ccggaaatcg aagaagcggt tgcgaaaaat gatcttctga 1755781 ttacgtctgt cctttccgga aaccgtaact ttgaaggacg tattcacccg cttgttaaag 1755841 gcaactatct tgcttcaccg ccgcttgttg tggcatatgc gctggctgga acggtaaaca 1755901 ttaacttaaa aaccgatcca atcggtgtgg gcaaggatgg tcaaaacgta tactttaatg 1755961 atatttggcc gtcaatggac gaaatcaatg cacttgttaa gcaaactgtt acgccagagc 1756021 tattccgcaa agagtatgaa acagtatttg atgacaacaa gcgctggaac gaaattgaaa 1756081 caacagatga agctttatat aaatgggata acgattcaac ttacatccaa aacccaccat 1756141 tctttgaaga gatgtctgtt gagccaggca aggttgagcc attaaaagga ctgcgtgttg 1756201 tcggtaaatt cggcgattca gtcacaactg accatatttc tcctgcgggg gcaatcggaa 1756261 aagatacgcc tgccggaaag tatttgcaag aaaaaggtgt ttcacctcgt gactttaact 1756321 cctacggctc ccgccgtgga aaccatgaag tcatgatgag aggaacattt gccaacattc 1756381 gcatcaaaaa ccaaatcgca ccgggtacag aaggcggatt tacgacgtac tggccgactg 1756441 gtgaagtaac atccatctat gatgcatgca tgaaatacaa agaagataaa accggtcttg 1756501 tcgtattagc aggaaaagac tatggtatgg gatcttcacg tgactgggct gcaaaaggaa 1756561 caaaccttct cggcatcaga acggtcattg cagagagctt cgaaagaatt cacagaagca 1756621 atcttgtatt catgggtgtg ctgccgcttc agtttaaaca aggtgaaaat gcggatacac 1756681 tcggcttaac gggtaaagaa gtcatcgagg tagatgttga tgaaacagtt cgtcctcgtg 1756741 accttgtgac tgtaagagca atcaatgaag acggcaatgt aacaactttt gaagcagtcg 1756801 tccgctttga tagtgaagtt gaaattgatt actaccgcca tggcggcatc cttcaaatgg 1756861 tgcttcgtga aaaaatgaag cagtcctgat gaatcaatag gaagagaagg catttcgctt 1756921 tctcttcttt ttatgacaca atgtgctgcg gaggtggcat atgctgaaaa aatggctcgc 1756981 agggatcctg cttatcatgc tagtcggtta tacgggatgg aatttatatc aaacatacag 1757041 caaaaaagaa gtcggaattc aagaggggca acaagcacct gatttttctt tgaaaacgct 1757101 atcaggagag aaaagctctt tacaggatgc aaaaggcaaa aaagtgctgc tcaatttttg 1757161 ggcaacttgg tgtaagccgt gccgtcagga aatgcctgcg atggaaaagc tgcaaaaaga 1757221 gtacgccgac aaacttgcgg ttgttgcggt aaatttcact tcagctgaga aaagtgagaa 1757281 acaggtccga gcgtttgctg atacttatga cttaacgttc cccattctga ttgataaaaa 1757341 agggatcaat gctgactata acgtgatgtc atatccaacg acatatatct tagatgaaaa 1757401 aggtgttatc caagacatac atgttggcac catgacaaaa aaagaaatgg aacaaaaact 1757461 ggatcttgat tagattcagt tttttttata ctcaaatatg cttacaagtt ttcagaattg 1757521 gaaaaaataa aagaatatgc ggaggtgaga agcgtgaaga agatgagaaa acgttctttt 1757581 catgagctcg tcatggaaaa caaaaaagag ctgatgacca atacagagta tttaaatcag 1757641 cttgaggaaa agcttgaaca gcgatttaag caaaaataac ctttaatttg tattcatgtt 1757701 tacccctcct tttgagaaac ctatctgttg aggagggata aacatgggaa acaacaagaa 1757761 aaacggtcag cctcaatatg ctccaagcca cttgggtaca aagcctgtaa aatataaagc 1757821 caataaaggg gaaaaaatgc atgatacttc aggacagcgg ccgattatca tgcagacaaa 1757881 aggcgagtag cgaaaattcg agtttatttc taggaggtac atccgaatga caaagaacca 1757941 aaatcaatat cagcagccta atcctgatga tcgttctgac aatgtggaaa aattgcagga 1758001 tatggttcaa aatacaattg aaaatataga agaagcagaa gcatcaatgg agtttgcttc 1758061 aggagaagat aaacagcgta tcaaagaaaa aaatgcaagg cgcgaacaga gcattgaagc 1758121 gtttcgtaat gaaatacagg acgaatctgc agcgagacaa aacggatacc gttcttaaaa 1758181 aaccagggaa acctggtttt tttctttctg atttgattat ggtaaaatgg ggctaaattg 1758241 acgttaaggg agcagagtaa tcttgcatgt atcaaaaaaa gaaatagaag tgcgttatgc 1758301 agaaacagat caaatgggga ttgtctatca cgcaaattat cttgtgtgga tggaggtcgg 1758361 cagaacggcc ttgattaagg acttaggctt tttatatagt gatatggaaa aaaaaggcgt 1758421 tctgtcccca gtcgttgata tcaatatttc ctataaaaag ccgcttcatt acggagaaac 1758481 cgcggttgta catacatgga tagaggacta taacggattt aaaaccgtct atggttacca 1758541 catttataat ccggccggtg agctttccat caaagccacc tcatctcata tttgtgtgga 1758601 taaagaaagc tttaagccaa ttcaattccg caaagctttt cctgattggc acacagcata 1758661 tgaaaaggcc aaaaaatagg gaagtgaacg ggatatggcg tttggtgtga aacgggagga 1758721 acttaaccgg tggaaacaag cagtgaaaag aggagaaatc gcatttttaa cacattactg 1758781 gctggatgac cgatttccag aagcaaagac cgtgacaaaa gccggctgtg cagacattga 1758841 taagctggtt cagtggggag cggcgtacgg gttaaaaaaa gaatggatcc ataagaaaag 1758901 tgaatttccc cactttgatc tgctggggga aacacaaaaa tatattttgg aacaagaaaa 1758961 cctaaccgat catcttatac gatttcattt gtaaaaaaag aacgcacatg aagtgcgttc 1759021 ttttttattg gtattcaaaa accggttcat cagcgtcttc tgaatagctg acgagaaggt 1759081 cgtggttatc aaagtaccat aaatcacttt cttcaataaa gaaggtaatg ccatcagctt 1759141 ctgcagtgac tccagcctct tgtggggcat ctttcgctac accgagagaa aaaccctttt 1759201 gaacgttgct gcagcctcca tagcggacga aaaagcgaac ctggtctccg ctttccaaat 1759261 cgagttcttc tttataccag ttcaatgcgt cttcgttaat tgtcatattc ataacagaac 1759321 acccctttgt tcttcatttg aattttctct attataaacg tattaggcta ttctgtgtca 1759381 aaagagaagt tttttaagct tataaccatt ttactttagg ttctgtttta ttgataattc 1759441 gtttaatgtt cgctcggtgt ctgtatatca caaaaatagt gagcagggta acgacaatca 1759501 ataaatacgt atcatggaca aagaaactat atataacagt atagatccct gttaacatcg 1759561 atgagagaga aacaaattta gtcaagtata aaaagatgaa gaataccgca accatcgtga 1759621 taaataacag gggtgcgtaa aatagcaaaa cgcctcctga tgtcgccacg gctttaccgc 1759681 ctttaaattt ggcgaagatg ggaaacacgt ggcctaaaac cgcaaagact cctgcaagaa 1759741 gcgggtgaat atcaacatgc atgagaaaag gcaatgcagt tgccagtgtc cctttcaaaa 1759801 tatctccggc tatgacgacc gaaccagctt ttacacccaa tgtacggaat gcattggtag 1759861 cgcctaagtt gccgcttccg tgctcccgaa tatcaattcc tttggcaagc ttgcccacaa 1759921 ttaagccaga tggaatgctg cctatcaagt aggccaaaat aatcaataaa gcaattaaca 1759981 tctacatttc tcctttttca aattcccttc tttttatttt aacatgagat gtcatgatct 1760041 gatgataagt ttttttgtaa agtttgctta caaatcaaat caaacatgca tcatattttg 1760101 atttctcctg ttttgatcgt gtaaaataag tgaaaaagga gtgacacacg atgcaaaacc 1760161 cttctaaagc ggaaattaaa gagattcttc aaagaagcaa acgtatagcg gtagtagggc 1760221 tttcagaccg tccggataga acgtcacata tggtttcaaa agcaatgcag gacgcgggtt 1760281 atgaaattat ccctgtgaac cctacaattg atgaggcgct aggtgtcaaa gccgtttcat 1760341 ctttaaaaga gatagacggt ccgattgaca tcgtaaatgt attccggcgc tcagaacagc 1760401 ttcctggagt ggcggaagag tttttagaga cagatgcgcc agtattttgg gcacagcaag 1760461 ggctagttaa tgaggaagca taccagatgc taaaagaaaa aggcagaacg gttatcatgg 1760521 atctgtgcat aaaagtggca cacgctgtaa caaaataggt gcagaactgc aaaaatcctt 1760581 gtaaattcaa ggatttttgc tttttaattt taagatattg tttgcgtatt acggtgaaac 1760641 agatacaata aagcttgaac agcttttttt gaataccttg tccagctggg tttcggccgt 1760701 tcgatttgcg aaggtctgct gctttatata taataaacaa acatacgttc tcatagtgta 1760761 aaaacagcac tagccgatgt tttgagaaga actgattcgt tagctctatg ttgcgattgc 1760821 aaacatattg gttataatga ggagtccaag gcagtactgg ctcgaggcga ggtttataaa 1760881 aaatatctta tatacaaatg atgtgtaaca ctgaaaagag aaagacaatg ttagtttttg 1760941 aaaggggttt gtacgtttgg ctagaaaaca gcaatttgat tacaacgaag atgccataca 1761001 ggtgctcgaa ggccttgagg ctgtcaggaa aaggccgggt atgtatattg gctctactga 1761061 cgcgcggggt ttgcaccact tggtttatga aattgtagat aactctgtcg acgaggtgct 1761121 tgccggccat ggagatcaca taatcgtcaa aatacataaa gacaatagta tttctgtaca 1761181 ggatagaggc cgcggcatgc cgaccggaat gcataagctc ggcaaaccaa cccctgaagt 1761241 gattttaacg gtgcttcatg ccggagggaa attcggccaa ggcggctata agacaagcgg 1761301 cgggctccac ggagttggtg catcagtcgt gaatgcttta tctgaatggc tgacggttac 1761361 cattgagcgg gacggttttg tctatcagca gcgatttgaa aatggaggaa aaccggttac 1761421 atctctcgaa aagatcggca aaacaaaaaa gacgggaact cttacacact ttaagccaga 1761481 tccaacgatg ttcagcacaa ccacttataa ttttgaaacg ctctctgagc gcttaagaga 1761541 gtctgcgttt ttgttaaaag gactgaaaat tgagctgatt gatgaacgca atgaccagcg 1761601 tgaggtcttt tattatgaaa acggcataga agcgtttgtt gcttacttaa atgaagaaaa 1761661 agacgtcttg tctgaagtgg tctcgtttga gggtgagcat cattctatag aagtggactt 1761721 tgcgttccag tttaacgatg gttattctga aaatattttg tcgtttgtca acaatgtcag 1761781 aacaaaagac ggcgggacgc atgagtcagg tgcaaaaact gcgatgacgc gtgcttttaa 1761841 tgaatatgcg cgaaaagtgg ctttgctgaa agaaaaggat aagaaccttg aaggcaccga 1761901 tataagggaa gggctttcag ccattatttc tgtccgcatt cctgaggagc ttcttcaatt 1761961 tgagggacaa acaaaaggaa agctcggtac cagtgaagca agatcagcgg tggatgcgat 1762021 tgtttcagag cagcttgctt actttttaga ggaaaatcgg gacaccgcaa cgcttcttgt 1762081 caaaaaagca atcaaggcga gccaggcgcg cgaagcggca cgcaaagccc gtgaagaagc 1762141 aagaagcggc aaaaaacgaa aaaaatcaga agcgacttta agcggaaagc tgacgcctgc 1762201 gggttcaaga aacccggcaa aaaatgaatt gtatctcgtt gagggagatt cagcaggcgg 1762261 gtcagccaag cagggacgag accgcagatt ccaggcggtt ctgcctttac gcggtaaagt 1762321 cattaataca gaaaaagcta agcttgctga tatctttaaa aatgaagaga tcaatacgat 1762381 cattcatgcg atcggcgggg gagtcggggc agatttctca atcgatgaca tcaactacga 1762441 caaaatcatc attatgaccg atgccgatac tgacggcgcc catattcaag tgctgcttct 1762501 tacctttttc tatcgctata tgaaaccgct cattgagcat ggcaaggtgt tcattgcgct 1762561 gccaccttta tataaggtca gtaaaggaag cgggaaaaag gaaatcattg aatatgcatg 1762621 gtctgatgaa gagatggggg atgtcctgaa aaaagtcggc aaaggctata ccattcaacg 1762681 atataagggt cttggagaga tgaacgcaga ccagctgtgg gaaacgacga tgaatccgga 1762741 gtcccgcaca cttgttaggg tcaaaattga cgatgcggca cgtgtagaga gacgtgtgac 1762801 gacgttaatg ggagacaaag tagagccgcg cagaaagtgg attgagaaaa acgtcgcttt 1762861 cggcttagat gaagaaagca atattttaga aaatgaaaac ttatcggtcg ctgaggaggt 1762921 ttaatgattg tcacagccag aattatttca tgatttacca ttagaagagg tgatcggcga 1762981 ccgttttgga cgctacagta aatatattat tcaagacagg gcgctgcccg atgcgagaga 1763041 cggattaaag ccggtacagc gcagaattct gtatgcaatg catacagatg gaaacacgtt 1763101 tgataaaaac ttcagaaaag cggccaaaac ggtcggtaac gtcatcggta actatcatcc 1763161 gcacggtgac agctcggttt atgaagcaat ggtgcggatg agccaggatt ggaaagttcg 1763221 taatgtgtta atcgaaatgc atggaaacaa tggaagcatc gacggagatc ccccggcagc 1763281 catgcgttat acagaggcac gattatctcc gatagcatct gagcttcttc gggatattga 1763341 caaaaacacg gttgaatttg tgccgaactt cgatgataca agcaaggagc ctgtcgtact 1763401 cccggcgatg tttcctaacc tattggtcaa cggatctacc gggatttcag caggatacgc 1763461 gaccgacatt ccccctcatc atctgggaga agtcattgat gctgtcatta agcgtattca 1763521 aatgccttct tgctctgttg acgaactcat ggaagttatt aaagggcctg attttccgac 1763581 aggcggtatt attcagggcg ttgacgggat aagaaaagct tacgaaaccg gaaaaggaaa 1763641 aatcattatc cgcggaaagg ctgaaattga aacaatcaga ggcggacgag aacaaattgt 1763701 cattactgaa attccatttg aagtaaataa agcaaacctt gtaaaaaaaa tggacgagtt 1763761 ccgtattgat aaaaaggttg aaggcatctc agaggttcgt gatgaaacgg atcgaacagg 1763821 gctgagagtg gtcattgaac tgaaaaaaga agctgatgcc aaaggcattt tgaatttctt 1763881 atataaaaat actgatttgc agatcacata taacttcaat atggtggcta tccataaccg 1763941 ccgtccgatg ctgatgagcc tgccgtctat tttggatgca tatatcggac accaaaagga 1764001 agttgtcaca aaccggtccg tttacgagct tcaaaaagca aaagacagac atcatatcgt 1764061 agaagggctc atgaaagctt tgtctatttt ggatgaagtg attgcaacaa tccgttcttc 1764121 tagcgataaa cgtgacgcta aaaacaattt gatcgcgaaa tatgaattta cagagcctca 1764181 ggctgaagcc atcgtgtcat tgcagctata tcgtttaacc aataccgata tcacagcgct 1764241 taaggaagag gcagaagagc tcggtaaaaa aattgaagag ctcgaatcta ttctgagcaa 1764301 tgataaaaaa ctgctaaaag tgattacaaa cagcttaaaa gcactgaaaa agaaatatgc 1764361 agatacgaga cgctccgtga ttgaagaaaa aattgaagaa attaaaatca atctcgaagt 1764421 catggttgca tctgaggatg tatatgtaac cgttacgaag gatggttacc taaaacggac 1764481 gagccagcgc tcatttgccg cttccaacgg tcaggacttc ggaatgaaag atacggacag 1764541 gatgctgcat cagtttgaaa tgaatacgac agacgtgctg ctgctcttta cgaacaaagg 1764601 aagctacatc tattgtcctg ttcaccagct gcctgatatc agatggaagg acatgggcca 1764661 gcatttttca aatctaatca ctattgaccg tgatgaaacg attgtaaagg ctataccgat 1764721 aaaagaattt gatccgtcgg catatcttct attctttacg aaaaacggta tggtgaaaaa 1764781 gacagagctc actcattata aagcacagcg ttattctaag gcacttgtag ccttaaatct 1764841 gaagggtgaa gatgaactga ttgatgtaca tgtaacaaat ggggaaagcc agatctttat 1764901 ggccactcac ttagggtatg gtctatggtt tggagaagac gaagtgaatg tagttggcgc 1764961 gcgtgcggca ggtgtcaaag ggattaactt aaaagaggat gactttgttg tctccggtga 1765021 gattcttcag caatctgatt caattgtctt gttcacacag cggggagcgg ttaaacgcat 1765081 gagtctttct gagttcgaga agacatcccg tgcaaaacgc ggtgtcgtaa tgctaaggga 1765141 actgaaaaag aatcctcacc gtgttgtagc actgttcgct tgcggtcttg aacagcgact 1765201 aatggcagaa acagaaaaag gcgacagaaa agaactgcag acaaaagagt tgcggacaaa 1765261 cgacagatac agcaatggct ctttcttttt tgatgaagag gaatcaggca aggttacagc 1765321 tgtttggcgc cttcatacag aacaataata aaaaacccgc tcatactata tgagcgggtt 1765381 tcgtttgttt tttatcagct ttcatggttg gtgaatagat ctgttacagc atgaatgact 1765441 tcaatcccct gccatacaaa taaattcagc gctgtgaaag aaaataagcc taaaatcacc 1765501 attcttaaga taaacaacat gtttaacagc ctcctcatat tttcgttaca taatcgggtg 1765561 atgttgaaca tgaagtttgc cgaaataaga cgattgataa aatttggcca gtataaagct 1765621 ttttttccgc tgacgtctgc gggagtatcc cgtacttttg ctttcagcgg tcagcagcag 1765681 aacagccatt gcccataaag cggtcagcgt aaatgcccct gtgatggatt tcttctcatc 1765741 atcagcattt tggccggctt tcatctcatg catttcctgc tggtcggcta cggctttata 1765801 atgatggccg atatcaaagg cgtggggaat tgagaacaaa tgaaaactgg caatcgccaa 1765861 gaataagatg gatgctttca atatcgttac ttttttcaaa tgatctcccc ctcctttaat 1765921 attactgaat atttttataa taatacccca atccatccta aaagtaaacc tgatttatta 1765981 aatttaaaaa taaatttaac tttgttaagt atatatcttt ttgcttattt ttgaaagaga 1766041 aaacttcttt tattagcgta tgtatacccg gtttatggtg tgaataaaaa catattttaa 1766101 atgatatgtt gtttaggatt tattacttta tttatgtgta aatcaaagag aaaggcaaga 1766161 gaatgggaag aaatgattac attgttaata gggtactctt tttttaaagc cagtttgcaa 1766221 ggaatgtttt tattcgtagg aaaataatag agaaggggtc gacagagtaa catctggcta 1766281 tgacaatatt cttctcgaaa aaacttccta attcgtcata ttgtgatata ataaaactcg 1766341 ttatgttaaa aaatctaaca tcaaaatcga attcgtattg aattgatgaa aacgggaggt 1766401 aaatatggag tcttttttca atagtttgat taatattcca agtgatttca tctggaaata 1766461 cctattttat attttaatag ggcttggatt attttttacc atacgttttg gttttatcca 1766521 attccgttat tttattgaaa tgttcagaat agtaggggag aagccggaag gaaataaagg 1766581 tgtttcatct atgcaggcat tctttatttc ggccgcatcc cgagtcggca cagggaattt 1766641 gactggtgta gccttagcaa ttgcgacagg cggaccaggc gctgtatttt ggatgtgggt 1766701 agtggctgca gtaggcatgg cttcaagctt tgtcgaaagt acattagcac agctttataa 1766761 ggtaagagac ggggaggatt tccgcggagg gccggcctac tatattcaaa agggtcttgg 1766821 tgccagatgg cttggcatcg tttttgcaat cttaattacc gtctcattcg gcttgatttt 1766881 taacgctgtt caaacaaata caattgctgg agcattggat ggcgcattcc atgtaaataa 1766941 aatagttgta gccatagttc tggcggtttt aactgcgttt atcattttcg gcggtttaaa 1767001 acgtgttgtc gctgtttcac agctaattgt gccggttatg gcaggcattt atattcttat 1767061 cgctttattt gttgtcatca cgaatattac ggctttccct ggcgttatcg ctacaattgt 1767121 taaaaatgct ttaggttttg aacaagtcgt cggcggcgga ataggcggca tcatcgttat 1767181 cggtgcgcaa cgcggacttt tttcaaacga agcaggaatg gggagcgcac caaacgcggc 1767241 tgcgacggct catgtatccc atccggcaaa gcaaggcttt attcaaacat taggcgtatt 1767301 tttcgataca tttatcatat gtacgtccac agcatttatt attttgctgt acagtgtaac 1767361 gccaaaaggc gacggcatcc aagtcacaca ggctgctctt aaccatcaca ttggaggctg 1767421 ggcgccgact ttcatcgcag tcgcaatgtt cttgtttgca ttcagttcag ttgtcggcaa 1767481 ctattattat ggcgagacaa acattgaatt tattaaaaca agcaaaacat ggctgaacat 1767541 ttaccgtatc gctgttattg ctatggttgt gtatggatct ttatcaggct tccaaatcgt 1767601 ttgggatatg gcggacctct ttatgggtat catggcgctg atcaacttaa ttgtgattgc 1767661 gctgctgtca aacgttgctt acaaagtgta taaagattac gcgaaacagc gtaagcaagg 1767721 acttgatcct gtgtttaaag cgaaaaacat cccagggctg aaaaacgctg aaacatggga 1767781 agatgagaaa caagaagcat aatataaata taaaacaaag ctgcattcaa tagttgaatg 1767841 cagctttttc attattggaa ataaatttaa tttttcgact cgaatgaaaa atgacgtgta 1767901 aagtcccaat tcagtccagt tttctttgtt ctatatgtgt catgtgtgtc ttattcattg 1767961 gaggtagagc aaattgacag gcttttaaac ctccccaaaa caagaaatta ggttgataga 1768021 caatcatgag aaagattttt acaatgagtt cgtgctcata agaagtgtag agccaaaatg 1768081 atgcgaagga ggaaaagatc agatatgaaa cggtcaatct ctatttttat tacgtgttta 1768141 ttgattacgt tattgacaat gggcggcatg atagcttcgc cggcatcagc agcagggaca 1768201 aaaacgccag tagccaagaa tggccagctt agcataaaag gtacacagct cgttaaccga 1768261 gacggtaaag cggtacagct gaaggggatc agttcacacg gattgcaatg gtatggagaa 1768321 tatgtcaata aagacagctt aaaatggctg agagatgatt ggggtatcac cgttttccgt 1768381 gcagcgatgt atacggcaga tggcggttat attgacaacc cgtccgtgaa aaataaagta 1768441 aaagaagcgg ttgaagcggc aaaagagctt gggatatatg tcatcattga ctggcatatc 1768501 ttaaatgacg gtaatccaaa ccaaaataaa gagaaggcaa aagaattctt caaggaaatg 1768561 tcaagccttt acggaaacac gccaaacgtc atttatgaaa ttgcaaacga accaaacggt 1768621 gatgtgaact ggaagcgtga tattaaacca tatgcggaag aagtgatttc agttatccgc 1768681 aaaaatgatc cagacaacat catcattgtc ggaaccggta catggagcca ggatgtgaat 1768741 gatgctgccg atgaccagct aaaagatgca aacgttatgt acgcacttca tttttatgcc 1768801 ggcacacacg gccaattttt acgggataaa gcaaactatg cactcagcaa aggagcacct 1768861 atttttgtga cagagtgggg aacaagcgac gcgtctggca atggcggtgt attccttgat 1768921 caatcgaggg aatggctgaa atatctcgac agcaagacca ttagctgggt gaactggaat 1768981 ctttctgata agcaggaatc atcctcagct ttaaagccgg gggcatctaa aacaggcggc 1769041 tggcggttgt cagatttatc tgcttcagga acattcgtta gagaaaacat tctcggcacc 1769101 aaagattcga cgaaggacat tcctgaaacg ccatcaaaag ataaacccac acaggaaaat 1769161 ggtatttctg tacagtacag agcaggggat gggagtatga acagcaacca aatccgtccg 1769221 cagcttcaaa taaaaaataa cggcaatacc acggttgatt taaaagatgt cactgcccgt 1769281 tactggtata aagcgaaaaa caaaggccaa aactttgact gtgactacgc gcagattgga 1769341 tgcggcaatg tgacacacaa gtttgtgacg ttgcataaac caaagcaagg tgcagatacc 1769401 tatctggaac ttggatttaa aaacggaacg ttggcaccgg gagcaagcac agggaatatt 1769461 cagctccgtc ttcacaatga tgactggagc aattatgcac aaagcggcga ttattccttt 1769521 ttcaaatcaa atacgtttaa aacaacgaaa aaaatcacat tatatgatca aggaaaactg 1769581 atttggggaa cagaaccaaa ttagttaagc ttttttttgg cggacatcag taacgatgtc 1769641 cgtttttatc atctaatagg aggtttgcgt tgtggatgaa atactgaaac agtatatggt 1769701 gctgtataaa aaaatgagta atatgataaa tggtcccgac tatccaggta aggaaaaaga 1769761 catccagcat caaaaagatc agatcgaagt ttacgaaaaa cagctgcagc aaggattttc 1769821 tacagattat gactatgatg tgtttgctga ttctgttatc aaatgcgcat atggcgatat 1769881 gacgctggaa gatttagaag ccgtttatta tggattgaca acaccatttt tttgatttgt 1769941 cattcagcag taaaatttca atttctgtct cactaactta agtatacttt gatattgaga 1770001 cagaaattta tttattttgt ttacttccta gaatatatat tatgtaaact agaaaagatg 1770061 aagaataaag ctttgctgtt tttatgtaca tcctttcttc ttcctgtaat tcagcaacaa 1770121 aataaaaaag cgatttccca atcggaaaat cgccaattca gacactctat tatttatgtg 1770181 tgtctttgtg ctcttaacga tttacaacaa atgttgtcac gctttgagct ggaagatgag 1770241 cccaaaaatg attgcctgat acagtgagat tcgttccagg ttgtagattg ctgctgctgc 1770301 tcgtgatcca tctagatacg tttgaagcag atccattctg caaaacaaag ttttggttga 1770361 ctcctgtgtt gcttttattg atggcaacaa taacgacctt gttgtcacct ttataggctg 1770421 acacgtaaac gttcgcatta gggtttttcg ttgcatcaat ccttacatag ccgggacgca 1770481 caaactttga gaaatgagcc atattgtagc cgcgtttgct gatcgtacca tcttctttca 1770541 taggtccata tgatcttcgg atgtaccacc atacataagc ttgaaagtcc ccctctacca 1770601 tcgcattgtg aatatgctgt gaaacatcca atgcctcagg ccatcgatcc gccgagttgg 1770661 tatcactgtt tggatagtat acttccgtca tccaaaggtc cttccccgct cctttttgtt 1770721 tgaaaagagg ataagggaat tggctgacct gggtgccgta caggtgagtt ccgagaatat 1770781 ccatattggc aagagcctgc ggatcgttca agatcgggtc cgacaaattc ttcaagtatt 1770841 gaaatgactc aggcgcaatg acgcgggcat tgatcgagcc ggcgttttct ctcataaagc 1770901 gaagtatttc ttgcggcgtc caccacgtcc actcgtgagc gtaatcaggc tcgttttgga 1770961 ccgaaatcgc gtaaagattc acaccattat tcttcatgaa ggtaacaaaa tcgttaagat 1771021 gctgcgcgta tgctgcgtac ttgttgtatt tcagccgttt agccgatgtg tcaccattcc 1771081 gattaaaggt ctcaaccata tcacttggag gattccaagg agaagcaaaa acgattgctc 1771141 cgtgtttgac cgcactcttt gcagtctcca cctctttata ccaattattt cgattttcat 1771201 ctacatgaat tcttaagatt gaaaatccta actggttctg tccattgcca aaagcagttt 1771261 ctctttgagc tgctgtaaga tccccagccc aagccggatg attcatccct ccaaaaccgc 1771321 gaatcacttg tttctctgca gatacattaa ctgttacatc acttgctgcc aaaacttcag 1771381 tagcgcctgg ccctaacatg actgacagca tagtgaaaca tactaatagt acacaaattg 1771441 ttttttttat gcgtggaatc atttattcct ctccttcgtc atgtgtcttt tacggtatta 1771501 aaaaatctgc atggcatatc cataatggcg ggctgttccg gtgctggccc gtacttcacc 1771561 cgcctcgttt ttaagcggtc ccattacgag tactatcttt gcgtaaactg ccagtaatca 1771621 aaattaaaca agtttcctgt acctgttccg gtaaatacaa agaatacttt gtgcacaccg 1771681 gttgccccgc ttaccgcagt ttctatttcc ctccacgttt gcgctccgcc tgttgaaggc 1771741 acattcagag ttccaacaag cttaccgtct gcactgtcga ggcgcacttc tattttcccg 1771801 cctaaagtgg atgctacatt tgctttaaat gacctggcac cgcccgctcc gaagtctgca 1771861 tttcctacag caatccagtc tccattttga atgcttgtta catgctgatt atttactggc 1771921 ccgccgggtg ctgtggactt ctctgtcaaa atgcgtccat tccaagcaaa cgtttcagct 1771981 tctacccggt tatatgggtt taaattggaa atttgtgtta cacctgcata atttgccgct 1772041 acctcttgaa tagatccatc tgcattatgc accagcttat taatatgggg agagcggtat 1772101 cctttgccgg ccccgaacag agcggaactg acagtttgcg catggtacac cacataccac 1772161 tcgtttttaa aattgaaaac agcatgatgg ttgtttccgc cacctccgaa aaatgcaccc 1772221 ggatttttca ggaagtgccc tctatatgta aagggaccca tgggacttga actggtcatg 1772281 tagccgatct cacccggggg tttatcggcc gggtgcgtgc cgccgaaatt gatgcaatag 1772341 gagtaataat atgttccgtt atacttgtgc aatcccgaat cttcaaacat gaaaggcgca 1772401 tcaattgtag atgcacttcc aacaacactc gtcatatcag gccccaattt tatgactcta 1772461 gccgttttag gattggccca ttgtccctgc gttggatttg aaacgccagg aacgcctccg 1772521 ccggcataca ggtaaccggt tccgtcgtca tctacaaata ctgccggatc aaaaagccat 1772581 acaacaccag acattcctgg cgtacttggc gttacgagcg gttttccgat tgggtcggtc 1772641 catggaccaa tcgggctgtc tgcggtgaga accccgatac ctccgccgct gtttgcgaaa 1772701 taaaggaaga atttatcctt gccattaatt tttttaactg cgattgacgg tgcccatgac 1772761 gcacctgccc attttgcaat tccacggcct ccattagctc cattggcacc tgctaccgga 1772821 atggctccgt ggtctgtcca gttcaccata tccgctgaag atatgacgaa tactctattc 1772881 aaattggcaa atgaattatc tttaattgtt ccgttgctat tatattcata gtcatcactt 1772941 gacatataga tgtagactct tccgttatag gtcagcgcaa ccggatccgc tcccaaatga 1773001 tggtcgataa gcggatttga attccctata tgttttgcaa ttgtagtact agtggcagca 1773061 tacgcagact tcccagataa gcagctcaat aataaaacta gaatccataa acatacgcta 1773121 cactttttcc tcatcacttc acatcctcct ttttccttaa aatgggggat tttcttttgg 1773181 aatttgataa caacaggtca cgaagattgc acgcataaag tagccggaag ctgtttagca 1773241 atgttcccag ttgttctgaa agctcatctt catgtgtctc cattctctct tttcttcgag 1773301 gagatcgcac cactccttca aaattgttca aaaaaacttc cccattccta gcgaccattg 1773361 tccagaaaat aaaaagacag gattgttcat ggcctcccac taatcacatt gaacggagat 1773421 tacatcatta tccaagatat ccctttatct aacatcctac atcattaaaa aaattgtgta 1773481 tagaaacttt tggaggagtt agtgttcgat tctacaaagg aactggatac atttattcat 1773541 tgataagatg gggctaacac tccgtttata tttgtatgtt ttcagacaca aaaaacagcc 1773601 gttcaatgcg gctgtttttt tcaagagtat aagactattg agcggtatac ccgctttttc 1773661 atgttttgtt catattttat taattgttta ttcaacactg tccgctatag taatccatat 1773721 caacaaatat gactgccact cgcatctttt atgaagggag gttcgttacg ctgaaagaaa 1773781 aaataaagac attaggccgt ttttgcaccg taggcgtcgg caatacgctg atagattttg 1773841 gtgtcttctt tcttcttacc gcttgtcatg tctcttatct gccggcgcag atctgctcct 1773901 atactgcagg tatcgtcaac agctatgtgt ggaaccggaa ttggacgttt tgtgtgaaac 1773961 gtaaggctga cgggaaagag atcgtgcgtt ttctcatgat taatattgcc gcgtcaggga 1774021 tcaccttttt gctgctttat ttgtttcaaa attgcggctg ctcgcttttg gtgagtaagc 1774081 tcgccgccac tatcggcgga atgatgatga attttatcgg aaaccgaatc tgggtatttg 1774141 gagattcgct gaaaaacata caggatcagg agtgaagatg aatgagaaaa aaagtgagaa 1774201 aagcggttat acccgcagcg ggtttaggaa cgagatttct gccggcgaca aaggcgcagc 1774261 ctaaagaaat gcttccaatc gtcgacaaac cagcaatcca atatattgta gaagaggccg 1774321 cagagtcagg aattgaagat atactgatta ttacagggag aaacaaacgc tcgattgaag 1774381 atcattttga tcggtcggcg gaattggaat tcaatctccg ggaaaaaggc aagacggaga 1774441 cacttaagga aatgcagcag attgccgatt tggccaacat tcattacatc cgccagaaag 1774501 aaccgctcgg attaggccat gcggtgctgt gtgcggagca ttttatcgga gatgagcctt 1774561 ttgctgttct cttaggtgat gatattatgg tgtctgaaac accggctctt cggcaattaa 1774621 tggatgtata tgacgtttat ggcacagagg ttgtcggtgt acagtcagtt ctccctgagg 1774681 atgtcagcaa atatggtatt ataaatacat cagggtctca agggcatgta tatgaagtga 1774741 acgatttagt ggaaaagcct tctcctgaag aagcaccttc ggaaatcgca gtaatgggac 1774801 gttatgtgct gaattcttcg atcttctccg ttttgaagac aattggcaga ggcgcgggca 1774861 acgaaattca gctgacagat gcgcttcgtg aggtttgccg taaggagccg atccatgccc 1774921 ggctgctgga aggaaatcga tatgacattg gcgataagct gggctgtttt aaagcgagca 1774981 ccgaaatcgg cttaatgcgt cccgaaatga gatctcagct tttggcctat ttagaagatg 1775041 tgatcaaacg ggaaacgaaa gaaatgctgc ggtaaaaaaa ttgtaaccat cttgctcgtc 1775101 aatcagtcat ataatagtga aaaagattag gacaggttgt gaagaatgtg ggcagtttga 1775161 taagcgaaat tttaacatgg ctgacgaaca tgggatatgc gggtattgcg attgggttaa 1775221 tgattgaaat cattccgagt gagattgtat tagcttatgg cggctatatg gtatcggagg 1775281 gcacgattgg atttattggc gcaattattg cgggtgttat cgggggcacc attgcccaga 1775341 tctttattta ctggatcggt cgctatggcg gcaggccatt tctggacaaa tacgggaagt 1775401 atttattgat taaaaagcat catatcgata tgtcggaaaa ctggtttcag aaatacggcg 1775461 ccggagttgt cttctcggct cgttttatac cggttgtcag acatgccata tccattccgg 1775521 caggtattgc cagaatgcct tttctcaaat ttgtggtact gactgtgctt gctatcattc 1775581 catggtctat cctgtttgtt tatttaggca tacagctagg aagccagtgg gatgatgttg 1775641 agaatatagc aggcacttat acaacaccga ttatgatatt ggctgttgtc gtgatagccc 1775701 tttattttgt gattaagaaa cgtacagcca tatttaaacg atagctagcg gatatgcata 1775761 ggggtgactg acgctcccct atgcatattt ttttacttgc gatgttgatt tgccagcttc 1775821 agattctccg ctaaaaatgc gacaaacact tcatcccgca cgagcgatgc ggcataattt 1775881 ctcttaataa accattctgc ctcttcaaac gctgcgaatg tttcgtcttg ggtttctccg 1775941 ttaatttgaa tattccattc gttgtctaaa gggaaaagaa aaaatctcat ttgtgcgcga 1776001 ttttcatata atgatccatt cgcagatccc tttagattat agatgttacg gaaggcatcc 1776061 ggccgtacag gatcaatacg gaaagcttca gctacaaaca actcgtatac ttcatcggtt 1776121 attgaacagc cggacgcttt tgcatgccct ccgccgccat atcggccggc gatttctgac 1776181 acatcgatgt aatcatgaat ggtgcggaga ctgactcgtt ttgaccccat gctcaaaatc 1776241 gcaatgtaat cgaggtgcgg gttatctttc cctagcctgt tccccagctc tgaatggtac 1776301 gattcagcgt gaacgatgcc tacacagtgt tcgtgaacaa aggtttgtac catttccctt 1776361 ttctttctgc ggaggtagcg ctcgattttt tcgtcttcta aatcaagcag tttttcttca 1776421 aaatcatcga agaaaaattc gtcatgcgtg gaaaggcgct ggatcatttt tgcttcaaat 1776481 tcatcgattg acagcaaaaa gaaaagatca ttaagccgct tcgcctgttt ttgatcgtac 1776541 cgctcccact cccatgtatc gtattggcgg acgagctctg tgaattgatc taaggcgttt 1776601 gtcggtttca tgaagccatt ttcaatgaga tagccatata aaagcgatgt cgcggatgtg 1776661 agccttccat catcgtattc cacctggaca aatccccatt catgctcatt caaatgaagg 1776721 gctgttttat gatggtcaat gagcttcact ttgccccctg catgaacata ctcattcaat 1776781 ctctcttcgt tttcttcatt gacggcgaga tcggtgatga ataacgcgtc ctgtctgttg 1776841 ctctccttcg ctttttctaa aaagtactgc acctgtgcgt ttaagccgtt gacagagtta 1776901 taccggatct ctacgtcttt tccgaacgcc aattttgcta cgattccgca tcctactccg 1776961 tccaagtcgt tatgtgaata taaatgatac ataatgtagg ccccttttta tgataaactg 1777021 acaattgccg ctagaggtgc ggcagccttt atttactatt ctaaaaaacc aagcgtttta 1777081 tgcaatggta attagttgac ataatgttgt tattgtaaat atataaagga gcgctttttt 1777141 tgcgctccta agttcttgct tttacaccgg ataaaccgga tgctttcgat tggtaaatgt 1777201 catttccttt gtcatgtatg ccttgagccg tttggccagc tcatcacgca gcgaattggc 1777261 tgggataaca gcatcaatga tcatttctga agccagacgg tagatattga tgtcctcttt 1777321 gtattcctcc cgtttgctgc tgataaatgc ggctctctct tcttctggca gctcggcgat 1777381 ttttttagcg tagacagcgt ttacagcggc ctcagggccc atgacggcga tttgggcggt 1777441 tgggagcgct agacagcaat ccggttcaaa tgccggccct gccattgcat acaaccccgc 1777501 cccgtaagct tttcggacaa tgacagagag ttttggaaca gttgcctccg acatcgcaga 1777561 aatcattttc gctccgtgtc tgataatccc agcctgttct acttttgtgc caatcataaa 1777621 accggggata tcggctaaga acagcaatgg gatatgaaaa gcgtcacata aggtaataaa 1777681 cttagccgct ttgtctgctg aatcgtggaa taagacgcct ccttttacct tcggctggtt 1777741 tgcaacaatg ccgacaggct gtccgtggat tcgtgcgagg cccgtcaata attccggtgc 1777801 aaataaggct ttgatctcaa aaaatgagtc ttcatctatg acccgctcaa tgagctcatg 1777861 catatcaaaa ggtgcgtttt gattttgcgg aatgacgtcg gcaagcggag tttcgaagtg 1777921 ttttggcggg cgtttctcat gaatgggcgc tttttcttga aaatttgccg gaaagtaaga 1777981 caaataagcc cgcaccagct gtatggcttc ttcttcagtt tctgcaagaa tatctccgca 1778041 gccggagatt gagcaatgca tacgggcgcc acccatttct tcgagagaca ctttttctcc 1778101 aataaccatt tccgccatcc ttggcgaacc taaatacatg gaggcgttac cgtctaccat 1778161 aacgacgata tcacagaagg ccggaatata agcgcctcct gccgcagatg gtccgaaaag 1778221 cagacagatt tgcggaatgc gtcccgataa tttgacttga ttgtaaaaaa ttcttcctgc 1778281 accgcgtctc cctggaaaga cattgatttg gtcggtaatt cgggcgcctg ccgaatcgac 1778341 taaataaatg agcggacagt ttaatttttc ggcgatttct tgaattctga tgattttttc 1778401 aactgttttt gctccccatg accccgcttt cactgttgaa tcattcgcca tgacgcaaac 1778461 ggtttggccg ccgattttgc cgatagcggt tacaactccg tcagcgggaa gcccgtctga 1778521 catacattcc gcaaaaaaag cgtcttctag ctcaatgtca tcgtcaaaga gaagggaaag 1778581 ccgctctctg acaaagagct tgcctttttc ccgattgctt tgatgatact tttccgctcc 1778641 gccttttcga atccgttcag cccgttctgt tcgttccttt tcataatcca tcagcattgc 1778701 ctccctttta tattcccttg tatacggccc gtcttttttc ttgaaaggcc tgaagccctt 1778761 ctctcctgtc ttttgtcggg atggtttgtt catacgcttt ttgttcaatc gcaaggcctg 1778821 tagcaagatc tgtctccaat cctttattga ttgcaaattt agcctgacgg acagcgatcg 1778881 gtccgttggc agaaatggct gcggccagtt cctctgcttt tggcataagg tcacaaggag 1778941 ccgtgacatg ctctacaagg ccgatttctt ttgcttcgtg tgcggtcacg cgtctgcctg 1779001 tataaatgaa ttcttttgct tttcctctgc caatcagccg gggcagcctt tgggtccctc 1779061 cagcgcccgg gataatagct aaccctgttt ccggaagtcc cagcacagct gcttcagttg 1779121 cgattcgaag gtcgcatgcc aatgccaatt ctagtccgcc gcctaatgcg cttccattta 1779181 tcgcagctat gaccggctgc ggcaaggcat caagtaaagc cgccgttctt tgaatgagag 1779241 atacactttc cagaacctga tcttctttca gttttatccg ttccttcagg tctgcccctg 1779301 cacaaaacgc tttttcaccg gtgcctgtga ggatgacgca acggatgttt gagttaaatt 1779361 caatttcctg gataatcatt tgcaggtttc taagcatttc cgctgaaaga gcatttgctg 1779421 cctgaggcct gtttaaggtg atcaacgcca tatgttcatt tttaacagta aaaagaatag 1779481 aatctcccat tgtatgcgtc ctccctttta tcaagatgat ttaaacacct gtaaatttct 1779541 gctcggcagc ggtttgccca ttttttcttc aatccatttg gccgcagata gcagtttttc 1779601 tagctttaca tttgttttga tatccatctg ttcaagcatg tacacgatat cctcagttgc 1779661 ggcgtttcct gatgaacctg gcgcatatgg gcatccccca agcccgcctg ccgagccgtc 1779721 gaacaccgtg atgcccattt ggagtgctgt gaccatgttg gccagagcgg ttcctctcgt 1779781 atcatgaaaa tgcagggcaa tttgattagc cgggaatcgt gccaaaagag cttcaagtac 1779841 agtttccact tgggcgggat tagctgctcc aatcgtatct ccaagcgaca gttcagaaat 1779901 cccaaattca aatagagctt ctgaaaggcg aatgacttgt tcaatgggga catctttttc 1779961 gtacggacag ccgaaaacag tcgagaggta ggctcttgtt gtgaggtttg ctttttgtgc 1780021 gtcgttgttt acttgtttga gtatatggag ggattcagaa gtggatttat tgatgttttt 1780081 tctgttgtgc gtctcgctgg cggacataaa aacgcaagcc tcgttaatgc ctccttcaag 1780141 tgcattctcc agtcctcttt gattcgggac aagtgccgcg tacgttaccc ctttttctcg 1780201 gtcgatgcct tttgctacat cgatagcatc tcgaagcgcc ggaatccatt tcgggtgaac 1780261 gaaggatgtg atttcaatat acgacagccc tgtccgggaa agctggttga tccaggttat 1780321 tttatcctct gttgcgatcc aaacgggctc gttttgtaag ccatcacgcg ggccgacttc 1780381 tttgattgtc acttttttag gatatggcat ggtcttcctc caaattattg agtggaattg 1780441 ctcagttcga gcagtacgtc tccttcattt acaaagtcgc cttccttttt tttgacttct 1780501 tttacgattc cgcttctatc tgcaacgatc gggatttcca ttttcatcga ttccaaaatg 1780561 gctacctcct ggcccttttc gatttggtcg ccggctttga cgtggacttt ccacaggttt 1780621 cctgccattt gtatgctaac cgtcatgaca actgcctcct ttataggtgc tgtttcaaaa 1780681 agtcagtcgt gacatcccct tctttaaatg cctttgttgc cgcagcctgt atgaggagcg 1780741 gaaggtttgt tttgattccc tctacacgat agtcgcgaag cgctgtctct agtttttcaa 1780801 ttgcttctgt tctggtttgg cctttgacaa tcatcttagc gatcatcggg tcataaaaag 1780861 gggtaacggt gctgtctttt gctaccgcac attcgtgtct gactcctttt tggtcaggaa 1780921 gtgaaaacgc agtgatcgta cctggtgacg ggaagaaggt cttgggatct tccgcgtata 1780981 ttcgaacctc tatcgcatgc ccgttccgtt ggatgtcttt ttgggagaat gtgagtgtat 1781041 ggcccgcagc aatccgcagc tgctgctcaa ctaagtccag gcctgttatt tcttcagtca 1781101 cggggtgttc aacttgcagt ctcgtattca tttcgaggaa ataaaaattt tgtttctggt 1781161 caactataaa ttcgatggtg cctgcgttcg tatagccgat tgccttcgct gcttttaccg 1781221 ctgtttgacc gatcttcatt cttagttcat cgtctacaaa tggagacggt gcttcttcaa 1781281 tgactttttg gtggcgcctc tgaacagagc aatcacgttc aaacagatgt actgtatggc 1781341 cgtgttgatc ggccaaaagc tgaacctcga tgtggcgcgc atgttcaata actttttcta 1781401 tatacataga cccgtcaccg aaaaaatctg ctgcgcgctt tttgtttccc tcgtacgctt 1781461 tttttaatgc ttcttcattt tcaacacgct gcattccgat gccgcctccg cccgctgaag 1781521 ctttcagcat gacaggatag ccgatttgac ttgcggtgcg gcaggctgcc tctatatctc 1781581 cgagggattc agaaacgccc ggcaccacag ggacacctgc agcctccatt gcttttcgcg 1781641 cttcaatttt gctgcccatc tttgcgatga tatcagggga aggtccgata aacacgatgt 1781701 tttcttgctt gcagcgttca gcgaaccggc tgttttctga taacaatcca tatcccgggt 1781761 ggatcgcgtc ggcttttgct tttttcgccg tctttatgat tctctctata tttaaataac 1781821 tttcactgac tctcgattcc ccgatcaaat atgcctctgt agcggctttt gtatggggcg 1781881 cgtccttgtc tgcttctgaa taaacagcga ccgttttaat gccgagacgg ctgcatgttc 1781941 ggataattct cattgcaatt tcaccgcggt tggcgatcag tacttttgta aacatgattt 1782001 cacctcattg acttgatgat aagttgaaca tttcaatcgt tttttctcgc agtttatatt 1782061 tttgaatttt gcctgaggcc gtcatcggat agtcatccgt aaaaataaca taacgcggaa 1782121 ttttgtggcg ggcgattttc cctttgcaat aggctttaag ctcatcaggt gaaacgcttt 1782181 taccgtcttt cagtttaatc caggctgcag cttcctcccc gaatttggcg tcaggcacac 1782241 caaccacctg tacatctaaa acagcgggat gctggtataa aaattcttca atttcccgcg 1782301 gataaatgtt ctcgccgcct ctgatgagca tatcttttaa tcttccggtg atgcggcagt 1782361 acccgtcttc atccatgaca gcaagatctc cggtaaacag ccatccgtca tgattgattg 1782421 cttttctggt cgcatctttg tctttataat agcctttcat gacgtgatag ccacgggtgc 1782481 acagttctcc ctgcatgcct ctttgaactt cttgacatgt cccgggttct acaattttca 1782541 cctcagtatg tggcagggca cggccggttg tttcgactct tcttatgaag gaatcatttg 1782601 ctctcgtttg tgtaatgact ggcgaggctt cggtttgtcc ataggcgatc gtaatgtctt 1782661 tcatgcccat cctttcaatc acagctttca tcacttcact tggacaggga gagccggcca 1782721 tgattcctgt tcggagcgtc gatagatcat atgcatcaaa atccggatga tgcagctcgg 1782781 cgataaacat ggtaggcaca ccatggagca ctgtgcattt ctctttttct accgttttaa 1782841 ggacggtaac gggatcaaat tcttgcacgg gtatcatggc tgccccgacg gatacacatg 1782901 ccaaaacccc aaggacgcat ccaaagcagt gaaaaaacgg aacagggatg cacatgcggt 1782961 cttgagaggt taaagccata cattcagcga tattagcagc gttattgatg acattgaaat 1783021 gggtcagcat cacgcctttt ggaaaccctg tcgttcctga tgtgtattgc atattaatca 1783081 cattgtcttt atccaggctg ttcattctct cttcaagctc agcatctgtc actgttttcg 1783141 ccaatatctc tgtatcgtcc caatgataca tgccagacaa tcgtttattg ccaatataga 1783201 tcagcgtttt taaaaaggga tagcgttcag atttcagttg gccgggcttt gcttcttgca 1783261 gttctggaat taaactgttc acgatgtctg gataagaagt gcccctgtat gaatccatga 1783321 taataagcgc cgcggcatcc gattgcttta acaagtaatc aagctcatgt gcttgataat 1783381 tggtattgac ggtcacgagc acggctccga tcttcgcagt tgcgaactgg acggcaagcc 1783441 attcagagat attagaagcc catatggcga cgtggtctcc ttttccaatc cccatccgca 1783501 tgagaccttt agcggtttga cggcacagac tgtcaaattg agcgtacgta tagcggatat 1783561 ttcggtctgg atacacaaca gcatctcgat cgggatacgc atcagctgtt tgttccagca 1783621 gcctgccgat tgtggaatgg atgagttcag ccattcattg ttcctccttt cttaatgata 1783681 ggaaagcgtt tacattttta ttttaaaagc tgtctggcga tcacgagacg ctgaatttca 1783741 gatgtgcctt caccgatttc cattaatttt gcgtcccgca gcatccgttc caccccatac 1783801 tctttcatat agcctgaacc tccatggatt tgaatggctt gattgcaagc tcttgtcgcc 1783861 atttcagatg cgaatagctt ggcgtacgcc gcttctttgg tgaacgggcg gttatgatct 1783921 ttcagccagg cggcttttaa caccatttgc cgtgccagat caatttccat cgccatgtca 1783981 gcaagcttaa attgaatcgc ttgaaaggaa gaaatcggct gtccaaactg ctttcgctct 1784041 ttcgcatatg ccaatgatgc gtcaagggcc gcttgggcaa tgccgactgc aagagcagcg 1784101 atggagattc gaccaccatc cagcgtatat agaaactgtt taaacccttt tgttggatcg 1784161 ccaagtaagt tggccgcagg cactcttaca tcttcaagca agatttccgc tgtattcgaa 1784221 ccgcggacgc ccattttatc gtacgggctc gtaatcgtaa gtcctggtgt gtcagttggc 1784281 acgattaatg cggagatgat gttttttccg tctttgtttt tgcctgttac ggcggttaca 1784341 ataactgtgc gtgcgtagct tgcattagtg atccagcact tttcgccgtt gattacatac 1784401 tcgtcaccat ttgaaatcgc ttttgtttga gtgcctcctg catctgagcc ggcatttggc 1784461 tccgtcaggc cgaatgatcc gagtgctgtg cctgaagcca gcggcgtcaa atgcgtctgt 1784521 ttttgctctt ctgttccgaa gtagtaaaga gggcttgcgc ctagcgagac cgctgcagca 1784581 tagcttaatc cagtactgcc gcaggctttg ccgacttctt caaccgctaa ggcatatgaa 1784641 atcgtatcac cgccagatcc gccgtattct tctggaaatg gaatacccat cagaccgagt 1784701 tcacccattt ttttaaatgt ttgcatcggg aactcgcctg tttgatctac atgttcagcg 1784761 tgaggagcaa tttctttttt cgcaaaatct tttaccattt cacgcaccat ttgttgttct 1784821 tttgtcagct caaaattcac atcgtttcct ccttcacatc tttgtaacat cctattaggc 1784881 gagttctata atcattccct gacaagaaaa gtctgaaaat taaaactgaa tcatttttta 1784941 tgtgataata tcagcgggat gagcaaatac atgcagtagg cgcataccat ccatatcgta 1785001 aacgcaataa cttggccctt tgataaagcc gggaagatga ggggaagatt ccaaagggaa 1785061 atcgtatcca tcaataaacc gaccgctgat ccccatatac ctagcttgat caccgcgaac 1785121 tgtgattgat cgagtttttg atagagaaag aacacaaggc ataaaacaag agcagtgccc 1785181 gctcccaaga gaagaaagtt cggcaaaaag gcttcttcag ccggatcagt caacacagca 1785241 tctccgaaca gcacaaaaaa taatgtggca cctaaccaga ctagaaatga aaacgtaaaa 1785301 cacgtcctgt acgtgtttct cttcgatttt atttttattt agtactagtt tctcagattc 1785361 caataatggt aaatgtccaa acaccgcctc catattcatg tgaatctcac ctttgttttt 1785421 taaaaaattc agcggtttac catcgtttcc tgtcccaaaa tcacttttta aaaaaagacg 1785481 acttagaaag ccgtccttct catttcttat tttgttgttc gtttggaagc tttgctttcg 1785541 ttatgaagcc ggtctgctga agtgacataa tacgtatatt tcttgttggg atctgccgtg 1785601 ttatctaaga aggtttgctg ctcatgtgtt tttctttgcg ttgccagcaa tgttctctgc 1785661 tttttccctt cggctctgta tatcgcataa taggctgttt ctttcgtttt ttgatttgat 1785721 gggtgatctt taatctgcag aagattgccg tttttgtctt cggtgacttt cgtaagcttc 1785781 ggtttttttg gggcggtatt gtcaagccaa ggcatttgcg gaaccagtgc cggcttgctg 1785841 taaagatcgg tgctgagact gtctttgatg ccaagcggat ttttgttgag gtccttgagg 1785901 ctgaaatgca tgcttccttt caccagttca agctggcggt tcaaagtgat ttgccgcaca 1785961 tattcctcag gatcggacca aggcggatca aaattgttat tgattttata tgctgcctgg 1786021 ccaatatata agtgaacagg cctatttttg acttcattgc tccaccaatc agccagcacg 1786081 tcgtaagccg ctgcgttaaa gccgatactc caataaattt gcggagcaat ataatcgatg 1786141 tcgccttctt ggatccaatg ccttgtgtct gcatatagat cgtcataatt tctgacgcct 1786201 gcttttgtat tcgatccggt cgggtcatct gcggcgtttc tccatactcc aaagggactg 1786261 atgccgaatt tgacatacgg ttttgcagct ttaattgttt ggttgatttg tttgacaagc 1786321 tggttcacat tgtcccgccg ccagtcatcg atattagaaa aagcgtcttt tccgtattgt 1786381 tcgtactgtg cttgatcagg aaattcctgt cccgctattt tataagggta aaaataatca 1786441 tccatatgaa cagcatcgat atcataatgt tttacgactt cttcaatgcc tttgacgata 1786501 aaatctctcg cttctggaat gcctggatga taatacagct ggtttccata ggcggcaacc 1786561 caatctggat gttttcttgc cgggtgatcc tcagacaatt tattaagatc tgtatgattc 1786621 attgtaatac ggtaaggatt aaaccacgcg tgaaattcca aatttcgttt atgggtttct 1786681 tcaatcataa atgcaagagg atcatagccg gggtccttcc cttggacacc ggttaagtat 1786741 tccgaccaag gcccgtaagc tgacggataa aaggcatcag ccgtcggttt aatctgaacg 1786801 ataacggcat tcattcccat tttttgcaca tcgtccagca gtttgatata ctcctgtttt 1786861 tgctctttca cagataaccc ttttttggac ggccaatcaa tatttaatac ggaagcaatc 1786921 catacggctc tcagctccct gtcagactgc gcattggcca taaacggaac ggaaatgaca 1786981 aacgttccga tgatcaagct gacaaggaaa cggacaatcg acttttggca aaccttcatt 1787041 ctgtttcttc tcccccatta catcactttc actattcgct attacggtat tcccgggcta 1787101 taaaagggtg attaacagaa tgtctatctc actaaataaa cgaaaaaagt cctaaagcat 1787161 gttgtgaacc gcttttagga ctttttatca ttcatcatgg tttgcagact ttttaacaca 1787221 tcaataagtt ttacgccgac accgacagcc gtttcaagga tcgcttgtgc tccggcaatg 1787281 gctaaaataa agatcagcgg tattgcaata cgaggcaaaa aaagatagcc aagtccgatc 1787341 aagatggcac accaaacacc ggcacaccag tagcaattga gcatgtatcc aaagttagaa 1787401 gccggcacgc ttttttcatc tacatgcccg ttttgatcaa caatcctttt ctttttcata 1787461 aaaggttttc ggataaattc tgtgattttg tcaaatacaa tcaaatgtgt cagcctgtaa 1787521 ctggctagaa tcagcatgat aaaagttaga aaagaaagac ggtccattga gaagcctcca 1787581 agaaaaagga tgatgttatc attcccaagt gtcccttatc cattcttgat acaaaaagaa 1787641 agacggacag agaatggcct ctgtccgcta atccgagctc attccctcca gttctcataa 1787701 taagaggata agaaaatgta gaaaaaagca gaaaaatgac aataaaagaa attatatgac 1787761 tatataatcc atatatgcac tatattaacg gatatttttt aaagtacaat aaaaaacatt 1787821 aaatttttat aacatttttt ttgaatatag tattatttct ttatttttcg tttctttttt 1787881 tatcaaattt ccggatataa agtgataaaa gtattgtttt acataaggtc ttatacacta 1787941 ctttttaatc ggactaattt tcttttgtgc atcattcttc taattgttgg aaggttcgac 1788001 aaagcgttat tacagacata aaaaaacctg ttttctcttg gaaaacaggt ctcccgctat 1788061 tattgatttg ccaaaatgac agcgatttga tcctcaatat cttttccatc ctcttcatca 1788121 atcaatccat ttagaagaat agagaaaaca agtttttttc cgctctttgt ttctgcgtac 1788181 cccgatagag agcttaccgt actgagcgat ccggtttttg ctcttacttt tccttgtgca 1788241 ggagtgcctt tcatgcggtt tctcagcgtt ccgcccacca ttctgtcagg attccccgca 1788301 acaggtaaag aatttagata agccgagaac caactctgat cctgaatgtc atataacagc 1788361 tgtgaaagtt gatctgagga tacagcatca atatgtgaga ttcctgatcc gtcccttaag 1788421 acgagtgatt tagaatcaac accaaattcc ggaagcgtac tgtttaacac ttcgagcccc 1788481 ttttcccagc tcccttctcc ttttttcact ttccccatct cttttacgag cacttcggca 1788541 tgtccgttat tacttaattt catgaacggc acaaaaagtt tcgataaagg cattgagcga 1788601 tgagagagca gcacatctga agaactaggt gcttcacccg tcttgatgtc ccctttcaca 1788661 gtaatacctt gtttttttag tgactgctta aataaatcta aggcatatcc ggcaggctcc 1788721 cagacagaaa tccattcctt tgtcttgttt gcgtcaaccg gtacgctccc ttcaattgta 1788781 atcgtgtttg ttccatgctc tctttcgatt gtgaggtctt tctctgaacc ggcagcagtc 1788841 gttttagcat cgttctttat cgttatataa tcggttttcg gagagacaga cacggcaggc 1788901 tcttcccctt ctttttgatt tggggtgacc tcaacaatca cagtgcctgc atcatagtct 1788961 tcgtttggag acgctgttag agcggagatt ggcgcgccat aatatgtgta ttcatcgctc 1789021 caaggcatat caggtgataa tcgcatgtca tcatgccacg tatcatcacc gatcagattg 1789081 cctttaatta cttttacgcc ggaatgtttc aatatctcag ccattttgtc aaaatcagat 1789141 ggtaaaagtg tcggatcgcc tttccctttc aaataaaggt taccattcag ctttttccct 1789201 ttcagtgttc catccgtccg gacctcggtt gtaaaagaat agttctcgcc aaggacagaa 1789261 agtgccgcgg ccgctgtcaa aagctttaga gaagaggcag gcctcattcg ggtgtctcct 1789321 gaatgttcat atagaacagc acctgtttcc gcagagcgaa cggtgatgcc ggccattgcg 1789381 ccttcgaggg caggatgatc agctaaaatc ttatcgatct gcccggaaag tgcatcttgt 1789441 ttttcagcgg caagcgcagc ctgatgcata taaggcaccg aagcaacgac gaaaagcagt 1789501 aaaacagcaa cataaagctt tatgcttttt ttcattaatt tccccgcctc tctgcgcttc 1789561 atcattggct attgatgatt cagttcaatg gtgatactgc ttttagctgt cgtttcttct 1789621 cccggctcca gcacttgtaa accagtgagt gacgaaggta aatcaagatt cactgcgttt 1789681 gtcacccatg tgtaaggctc agggcataaa tacccttgtt ttccgtccgc attgtataca 1789741 acccaatgtt taaactgttc atctgcctta taaataatgc tgatatgtgc atgctgatga 1789801 taaatgactg cctggttttc tccgcccctc ttctgataag aagataaaaa gacatcatcc 1789861 agctgcttgt ggcgcaaatc cattccttca tgcaaagctt ctttatacgg gacatccatc 1789921 agcttcccgg tcggcagcag gcgttcatcc aactcccatt gctgatctgc tgtcagggag 1789981 aataacgagc tttctgccgg aaatataaat gtagtatgat aaccaattcc ccaaggaaac 1790041 gcttcctttc ctttgttcat gaccgtcgca tgtttaaata gggtattctc cttgatcgtg 1790101 tatgtcatcc gaacgacggc atgatgagga aattgcttct gcacatgggg aagctcagaa 1790161 agatcaattt ctgtttcaac aatcactcct tcatcagttt gcttcgtggt cacgacattc 1790221 cacttttcat ggtaaagaaa cccgtgaaga tggttgtgtt tatccttctc gttgatatca 1790281 aaatgatacg ttctgccccg gaaactgaat gtaccgtcac ttatgcggtt aggcgggaac 1790341 aggattggaa tgccatacaa tgttggtgtg tcgtgaaaac tttctgctgt ttccggttca 1790401 cgcaaaagct ggacatttgt tgttttgtcc acgagagaaa tgacgttgct cccccactca 1790461 gggacaacaa tcatttctag atgttcgttg cccgctttga tggccggcgt tcccaaatac 1790521 gtgattttct caataaagtt tgccatgttt actcaacctc tccttgattc attgctagta 1790581 taagaattca atgtactgta ccatatttcc tccattttat attttcccct atcaaataaa 1790641 aaaacaccgt tcaaacttat gaacggtgtg attcggaggc tattggatga gacgtgtgat 1790701 ttgtttcttt ttccagacga attgataata cccataaatc aacagcaagc tgacggcaaa 1790761 cgcagctgga taaccaaccc agacgccgag tatttcaagc tttgtatagt gagaaaggac 1790821 gaaagcgaca ggcacctcta ctccccagat tgcaaaaata ctgatgacgg tcggccataa 1790881 aactgttccg cttgcccgca tcgttgcaga aataatttgg gcatttccaa acagcaaata 1790941 gctccacagt gtaatcatca aaagacggtg cgcaatgtaa agcgtctctt gctcggttaa 1791001 aaataacgat aaaatctgat gtgaaaaaac atagatcaga atgatcagta cgccgccaat 1791061 gatataattc agccaaatcc caacgcgaat gacctgcttt aagcggtcaa actcgtttgc 1791121 tccgatcgat tgcgcagcga aaatagaaac cgcaatacca aggctgacgg ccggcatctg 1791181 tacatagctg gccacctggt tgaccactcc gtatgcagct gttgcattag agccgtaatg 1791241 attgacgaat gaaataaccg ctatctctga taatgagaca agaatcatat tgatgcttgc 1791301 tgggacccca agacgcagca ggagaaccag cagttcctta tccattttca aataacgacg 1791361 cactgtttta tcaaattgca gcgggtgttt tcgctttcgt aaatacacca ttaacacgag 1791421 aaaagtcgca atcgtggaaa tgacagttgc atatgccgag ccgtatatgc ccagtttcgg 1791481 aaaaccaaac atgccaagga ttaaaacagg caaaagcgcg atgttgatga ccgtgctcac 1791541 aatcagcgta taaaacggtg tcttggaatc tcctgttccg cgcaaaaagg tagtatatgc 1791601 aaaatataaa aacataaacg gcatagcata aaataaaata cgtgcatagt tagcgctgac 1791661 atgaatgaca ttttcaggtg ttcccattaa acgaaggata tccagggtga aaatactgcc 1791721 gataacggct aacacaacgc ctaataaaaa tgtaaacgtg agtgtcgtcc cgacaacagc 1791781 ctttagccgt tcctcatttt tcgctccgta agcttgtcct atcagaatcg aacttcctga 1791841 accgatccca atcgtaaatg agattaaaag aaaaaataac gggaaaaagg atgatacagc 1791901 tgccactgca tcaacaccga gccatctgcc tacagccatc atcccgacta gctggccgac 1791961 tgattgcagc acattgctca gcagaagcgg cactaaaaag agtgacatcg accgccaaac 1792021 tgatggtttg cttttctttt gagttacaag aggttcttgt gatgtttcca tattaaagga 1792081 ctcctttatt tgaaatcgtt tttaaacatg ccctcatttt ttgacaaaaa caggatatgt 1792141 aacatgttat tattcatcac tgcacttatg aaacccttcc cgattcttct aattttacac 1792201 atctttttag cttatgaaga ataaactagc aagtaatggc gtattttttg tgagtaaaag 1792261 aataaaaaat aatttatgca aaagtattgt aatctatccg taattattgt aacatttgta 1792321 acataagaga aagagatttt gaaggagaga gcgataatga aaaaatgtct tctatttcta 1792381 acaaccattg cacttattct gtcattaagc acaaatgcat ttgcgaaaaa tacatcaggc 1792441 gatttatcac aaaaacaagc attacagttg gcattatccg ctagagaaca tttttggaac 1792501 accatgagcg gccacaatcc gaaggtgaaa aaagcagttt gcccatcagg cacattcgag 1792561 tatcaaaatc ttcaatatgt atacatgtgc agtgatctag gcactaaagc aaaagcggtg 1792621 aattatttaa ctcctatttt tacaaaaaca gcaatcgaaa aaggctttaa agattatcat 1792681 ttcactgttt caaaaggaaa acttgctgtt ccaatcggtg acggagacaa tcttttgaat 1792741 tggaaaaaat caactgctaa actgatctct aaaaaaggca gcacaatcac atacgaattt 1792801 actgtcccta cattagacgg atccccttct gcaaaacgga aagtgacatt tgtgaaagaa 1792861 aataaaaaat ggaaagtcaa tcaatttgac gcagttatat aagaaaaacg cccggtataa 1792921 gcgggcgttt tttatttggt ttgcataaag aaagacaaca ggcgaaaagt gcctgttgtc 1792981 tttttgtgaa tataacgctc taggagagat tcgaactccc gacctgcagt ttaggaaact 1793041 gctgcactat ccgctgtgct actagagctt ttggtattta tatagtagct ctgatgatca 1793101 atattttcaa gcgatttgta ttaaagccct ccaaaaacct tatatgcggc tcttgtcgta 1793161 tcttcatcaa taccgatata ccgcattgta attgatggtg atgaatgatt cagtattctc 1793221 tgcagctcgg cgatgtcttt cgttcgctga taaaaatgat agccaaacgt tttccggagt 1793281 gtatgcgtcc ctatctcctc aagtccgcac gctgcagcgg cctctcttaa aattctgtag 1793341 gcctgaatgc gggaaatcgg cttcctggtc cgcactgatt taaaaagata ttcgttttcc 1793401 ttcatgtctt tcgtatactc gtatatttcc tgtttcagcg attctaaaat aagaatcttt 1793461 cttttctttt tcgttttgct ttcagtcgcc cataaatgat ctttattttg aacgtccttc 1793521 acttgcagcg gcagaatatc agaaatacgg agcgcgctgt tgatgccgaa aataaacaga 1793581 aaataatccc gcttgttttt gttaagcaaa tactgtttga cttcttggat tttctctaga 1793641 ctgcgaatcg gctgtacaat atgcatcaaa aaactcctta aaaaccgtta tgtaacattt 1793701 tgaggtctat gttactatta tagctgaaaa acgttgaatg tcaaagtgcg gcggcgttta 1793761 tgtaacataa tatacatagt gttacataag cttttaaaaa agcttcttcc aaccttcacc 1793821 ctataaaata agctttaaag cctcttataa agcttttaac ctcttggata cttatccccc 1793881 tactaatcat caaaaaacct cttaaaatga aatctgacac tcccaatttt ctggagcttc 1793941 cgcaaaaata tacaaaaaaa gacacaattt caaattgtgt cctaatcctc atcctttaca 1794001 tcaatatctt ccgggatcgg ttcatttaat atttcctgca caagtgcttt gtaattctcc 1794061 agctgttcga gatgcgtttt gaactgttcc ttataaatca aaaattgctc cccgtcatga 1794121 acggctctga ttttcccttc gagcaccaag cttttaatat aatcctctga aagatttgta 1794181 tattctgctg tttcttcaat cgttaaatac atatagcagt cccttcttaa tccgtatgct 1794241 gattctaata tagcacatgg ctcatatcaa tataatcaat tctgcacaga aaaacggcat 1794301 tatgcactat ataatatacc atttgtcact tgtgaaaacg ctgtaatttt tttacgctaa 1794361 gattgtaaca atacagcttc atataggagg gagaacatga aaagaacgtg gaacgtctgt 1794421 ttaacagctc tgcttagtgt tctgttagtc gctggaagtg tcccttttca cgcggaagct 1794481 aaaaaaccgc ccaaaagcta cgatgagtac aaacaagtag atgttggaaa agacggcatg 1794541 gttgcgaccg cacatcctct tgcttctgaa atcggtgctg atgtgctgaa aaaaggagga 1794601 aatgctattg acgcagcggt tgccattcaa tttgcactca atgtaacaga gccgatgatg 1794661 tcaggtattg gcggcggcgg ttttatgatg gtgtatgacg gaaaaacgaa ggatacaacg 1794721 ataatcgaca gccgtgagcg tgctccagca ggcgcaactc ctgatatgtt tctggacgaa 1794781 aacggcaaag caattccttt ctctgaacgt gtaacaaaag gtactgccgt tggtgttcca 1794841 ggcactctga aagggctgga agaagccttg gataaatggg gaacccgttc gatgaagcaa 1794901 ttaattaccc cttctattaa actcgctgaa aaaggctttc cgattgattc ggtgttggca 1794961 gaggccattt ctgattatca ggaaaagctt tcacggactg ccgcaaaaga tgtattttta 1795021 ccaaatggcg aaccgcttaa agaaggagat acccttattc aaaaggattt ggctaaaaca 1795081 tttaagctta ttcgctccaa aggcactgac gctttttata aaggaaaatt cgccaagacg 1795141 ctttctgaca ctgtccagga tttcggcgga tcaatgacag aaaaagattt agaaaattac 1795201 gacattacaa ttgatgaacc gatttgggga gattatcaag gctatcaaat cgctactact 1795261 cctcctccaa gctccggcgg tattttctta ttgcaaatgc tgaaaatcct tgatcatttt 1795321 aacctttcac aatacgatgt ccgctcatgg gaaaaatatc agctgcttgc tgaaacgatg 1795381 catttgtcat atgccgaccg tgcgtcttac gcaggtgatc ccgaatttgt aaatgttcct 1795441 ctcaaaggcc tgcttcaccc cgattatatt aaagaacgcc agcaattaat caacctagat 1795501 caagtgaata aaaaaccgaa agccggtgac ccttggaaat accaagaagg atcagcaaac 1795561 tataaacaag ttgaacagcc gaaagacaaa gtagaaggcc aaacaaccca ctttacagtt 1795621 gctgaccgtt ggggaaatgt tgtttcttat acaacaacaa tcgaacagct attcggaacg 1795681 ggtattatgg tccctgatta cggtgttatt ttaaacaatg aattaacgga ttttgatgcg 1795741 ataccaggcg gagctaacga agtacagcca aacaaacggc ctttaagcag catgaccccg 1795801 acgattttat ttaaggatga caagcctgtc ctcacggttg gatctcctgg cggggccaca 1795861 attatttcat ccgttttgca aaccattctc taccacattg aatatggtat ggaattaaaa 1795921 gcagctgttg aagagccgag aatttacaca aacagcatga gctcttaccg ttacgaagac 1795981 ggagttccta aagatgtcct cagcaagcta aacggcatgg gccacaaatt cggcacaagt 1796041 ccggtggata tcggaaacgt gcaaagtata tcgatcgacc atgaaaacgg cacctttaaa 1796101 ggtgtagctg attcaagcag aaacggcgcg gcgatcggca ttaatttaaa acgtaaataa 1796161 ataaaaaact gtactcgctt caaatgagta cagttttttc atgcagatct ttaaaataaa 1796221 aactgacaaa cgtctttatt ctgctaatgc acgtctatct tcatcttttc atttcgttta 1796281 tctcatcaag aaatgtctga aacgcactcg taataaaaaa gtctttcctg tatataaaga 1796341 cgatctctaa gtcttgatat gatggtggca gctgatgaat ccatacattt gtacgatgct 1796401 cggagccgtc aacagcggac tttgggagca gcgccgtacc catcccggcg gaaacacctt 1796461 ttataatagc ctccaatgtg ccaaactcta tgattttttg attgtgtatg cctgcttcct 1796521 ctagtaatct tttgaccctg tcacgatgag aacagccagc cccaaaaaag agcatcggct 1796581 gctgaagcat gtcttctgcc gtcccttctc gtgatgaaat caaaactaat tcatcatggg 1796641 agacatggag ttgtctaact gcagcgtgtt caaccggccc atatacaaaa gcgccatcaa 1796701 ctttatgatc aagaacctgt tgaatcaaat gatgcgtatc agctgtgttc actgataaat 1796761 ccacttcagg aaaacgcctg aggaaggatg ctgcatgctc aggcagatgc gttaccgcca 1796821 ttgtttccag tgatccgatc cgcaaaggcc cttttggttg cctgctcatt cgggtcgatt 1796881 tttcagcttg gtctaacagc gataatactt gatctgcata ttgtaaaaga ttttctcctg 1796941 cagcagtcag cttcattccc cgattcgttc gatgaaaaag cctgatattc aaatcttcct 1797001 caaggttatg cactctggct gtcacattcg actgaacata attcagcatt tgggctgctt 1797061 tcgttatgct tccttcgcga gcaacagcct gaaaaatctt taaatctccg ctttccacgc 1797121 gctctcacct gcttgctatg atgaaaagtg atattggcta tcatatttgt tcattttact 1797181 cgaagaaaac cgctatgtaa aatatgtaaa gatatgaaaa tacaattaat gaggaggcag 1797241 acagcatgaa agctgtaatt cacaacggaa aagccggtct tctggggtta tcagttcagg 1797301 acgttccatc aacaaagcct ggatacggag aggtaaaggt taaattaaaa tctgcaggcc 1797361 tgaatcatcg tgacttgttt cttatgaaaa acaaatctga acaagatcct cacatgatac 1797421 tgggttctga cggcgcgggt atcatcgaag agattggtga aggcgtgaaa aatgttactg 1797481 ttcagacaga agtagtcatt ttcccgacat tgaactggga tttgacagaa aatgttccac 1797541 ctgtacctga gattctggga ggtccttcgg acggaacact tgctgaatat gtgatcattc 1797601 cttcacaaaa tgcaatcaaa aaacctgctt atttatcttg ggaagaagcg ggcgttttac 1797661 ctttatccgc tttaactgca tatcgggctc tgtttacaaa ggggcaatta aaaaaaggcg 1797721 agcatctatt gatacccggc atcggcagcg gtgtagcaac ctacgcttta tttatggcta 1797781 aggcgattgg ggcaacagta agcgtgacct cccgcagtga ggagaaaaga aaaaaggcgc 1797841 tgaaattagg tgctgattac gcatttgaca gctacagcaa ttgggatgag cagttgcagg 1797901 gaaaaaagat agatgttgtt cttgacagca taggacctgc cctcttttcg gaatacttcc 1797961 gccatgtaaa accaaatggc cgtattgtca gctttggggc aagctcaggg gataatctca 1798021 gttttccggt gcgttcttta ttctttcctc aggtcaatgt tttgggaacc tcgatgggaa 1798081 gcggtgagga atttcaagct atgctcgctt tcattgacaa acataagctg cggcctgtaa 1798141 ttgaccggat atatccttta gaaaaagcat gtgaagcata taaaagaatg caggaaggca 1798201 gacagtttgg aaacatcggg atcgtaatgg aataaaaaaa gaaaccggct ggcagccaga 1798261 ccggtttctc ttatatgata atccccttta tttacggaag aactgaactc cccatcaaat 1798321 atcgatccac ttcacgcgcc acttcacggc cttcattaat cgcccatacg attaagcttt 1798381 gccctcttct tgcatcccct gcggcgaata caccatcgat atttgtttga taatccccat 1798441 atgctgcact gattttgtta tttactgaat taacaccgaa ctgtttcaac agcggctgtt 1798501 ctgtgccttc aaagccgata gcgataaaga caagctgagc aggccatact ttttccgttc 1798561 caggcagctc gcggaactcg tattttccat gctcattttt cactttttcc atttggatgg 1798621 tatgaagctc tttcagcttt ccgtttttat ccgcgaccat ttttgtcgtt tgaatggagt 1798681 attctctcgg atctcttccg aattttgctt ctgcttcctc gtatgcatat tcaagcgtaa 1798741 agacgtgtgg ctgttcaggc cacatattgt cattcgtgcg ggctggcgga agtttcgggt 1798801 gtttgccgaa ttggtgcacg cttttggctt tttgacgcag agcggtagcc acacagtcag 1798861 ctcctgtatc tccgcctccg attacgatga catctttccc tttggcatca atgaattgct 1798921 tgtctttaaa attagaatct aaatagcttt ttgttgcaag tgtgaggtag tccattgcgt 1798981 aatggactcc ttttgagtcg cgtccttcga ttaagaggtc ccgctgtttt tgagcgcctg 1799041 tgcataagat cacagcatca aattgctcct ttagctcatc agctgtaatg tcaacaccga 1799101 tttctgtgtt cgtgacaaaa tcaattccct cttgcgtcag caatttaatt cggcgttcta 1799161 caatgccctt ctcaagcttc atgtttggaa tgccgtatgt taaaaggccg cccgctctgt 1799221 ctgctcgttc aaaaacagtg acggaatgtc ccgcttgatt cagctggtca gcactcgcca 1799281 gtccggctgg gcctgacccg acgatggcca cttttttgcc tgttcgtttt tttggaattc 1799341 taggttgaat ccagccgttc tcaaatcctt tatcgataat ggtccgctcg atgtttttaa 1799401 ttgatacggc cggatctgaa atcgctaaag tgcatgatcc ttcacaagga gcggggcata 1799461 cccgccctgt gaattcagga aagttgtttg ttttcaacag acgttccaat gcttccttcc 1799521 atctgccccg gtagacaaga tcattccatt caggaattaa gttgtaaatc ggacagccgg 1799581 atgtaaatcc gttaatgtcc gcaccgatct ggcaaaacgg tgtaccgcaa tccatacacc 1799641 gcgccccttg ccgtttcgat gcttcttctg aaaaaggagc agaatattct ttccaatcct 1799701 ttaagcgagt gagagggtcc cgctccgcag gtttttctcg tttgatctcc ataaatccag 1799761 ttggtttccc catgttcctc tccccttcct tactgtacta ccgcttgttt ttgtcccgat 1799821 gctgctgtat tctgctttgg cttcgtgttg gcctcaaaag cgaacatgat ggcttcttca 1799881 tctgataaac ctgcagcttt ttgctcttcg atgcttgcga gcatttgttt atagtttttc 1799941 ggaatgactt tgacgaattt tttcacactg tcttcccatt gatctagcag atcttctgct 1800001 ttttggctgt ttgtatacgc agtatgtctt tcaagcattg ctttgatttg ctggatttct 1800061 ttctcatcct ctaatgattc aaataaaatc atctcaaggt tgcatttgcg tttaaacgct 1800121 ttgacatctt cggtcagtac ataagcgatt ccgccggaca tacctgccgc aaagtttttg 1800181 cctacatcac cgagaacgac aacgctgccg ccagtcatgt attcacagcc gtggtcgccg 1800241 atgccttcta caactacgtt cacaccgctg tttcgaacgg caaagcgttc accagcacgc 1800301 ccgttaatat atgcttctcc gcttgtcgca ccgtaaaaag ccacgttgcc gataatgaca 1800361 ttgtcatccg aagcagagtt gaatccttct gatgacttga cgatgatttt tccgccagaa 1800421 agcccttttc cgacgtaatc atttgagtct ccgtccaaat aaagcgtcat ccctttagga 1800481 acgaaagctc caaagctttg gccggctgat ccggtaaagt gcagcttgat tgtatcttca 1800541 ggaagacctt cttctccgta acgctttgag atttcactgc cggttatcgt tccggctaca 1800601 cgatttgtat tattgatttc aatcgaaata tcagcttctt ttccagattc gatggcttct 1800661 tgtacggccg ggagaattgt tgtaatatca agtgattgat caattttatg attttgcggc 1800721 gattggaacg tccgcacccc ttcaggctga taaagaaggg tagacaaatc aagctggctt 1800781 gctttccagt gctcctttgc ccgttcactt gcatgaagta catcagtgcg gccgatcatt 1800841 tcatcaaatg tcttgaagcc taacgcagcc atgtactcac gaacttcttc ggcaatgaac 1800901 agcatatagt tcacaatatg gtcaggatct cccatgaact ttttgcgaag ctctggattt 1800961 tgtgtcgcta caccgacagg gcatgtatcc aaatggcagg cacgcatcat gacacagccg 1801021 agtacaacta acggagccgt tgcgaaacca aattcttcgg cgccgagcaa ggcagccatc 1801081 acaacgtcgc ggcccgtcat gagctttcca tctgtttcta atacaacacg gtcacgaagt 1801141 ccgttcagca ttagtgtttg atgtgcttct gcaaggccaa gctcccacgg aagccctgta 1801201 tgtttaatac tggttttcgg agaagcgcct gtacctccgt catagccgct gatcacaatg 1801261 acatctgcag tcgctttggc aacacctgca gcgattgttc ctacacctgc ttttgacacc 1801321 agctttacgc tgattcttgc gtcacggttg gcatttttca aatcgtggat cagctgggct 1801381 aaatcctcaa tcgaataaat gtcatggtgt ggcggaggtg agattaatcc gacacctggc 1801441 gttgacccac ggacatcggc aacccatgga tataccttgt tgccaggaag ctgcccgcct 1801501 tcacccggct tagcaccttg agccatttta atctgcagct catcagcatt gacgaggtaa 1801561 tggcttttga caccaaaccg tccggatgca atttgtttga tcgcacttct tctatcatcg 1801621 ccgttctcat ctggaacaaa gcgtttggga tcttctccgc cttcaccgct gttgcttttt 1801681 cctccaagac ggttcattgc gattgctaaa gcttcgtgcg cttccttact caaggacccg 1801741 aatgacatcg cacccgtttt aaaacgtttg acaatcgatt cagcggattc aacctcctcc 1801801 aacttcaaag gcttgcggtt tccgtcaaat gcgaacaagt tccgcaaaaa tccgatgcgt 1801861 tcttcatcag ccgcttttgt atactgttta aacagattgt aatcatttct gcggcacgcc 1801921 cattgcaaag tatgaatcgt tttcggatta aacgcatgat gctctccgcc atttctccat 1801981 tggaagtcac ttcccggttc aagcgttttg ctgtaatcat cctgatacgc ttcccggtgg 1802041 cggcgctgtg cctcttctgc aattgtttgt aaatcgatgc cgcctagctg tgatgcagta 1802101 cctgagaaat agcggtcgat cacatcgcgg ctgattccta ccgcctcaaa gatttgtgcg 1802161 cctctgtagc tttgcacagt tgaaattccc atcttggaca tcacttttac gacgccctca 1802221 gtaatgcttt ttccatattt gctaaccgct tcttcatagc tgatatccaa acggccttca 1802281 tcaatttcct gcttgtaggt cgcataagcg agataagggt taatcgcatc tgcgccataa 1802341 ccgattaacg ctgcaaagtg atgcacttca cgtgcttctc ccgattccac aataatgctg 1802401 accttcgtac gcagcccttt gcggattaag tgctggtgca gtgcgcttac tgccagaagc 1802461 ggcggaattg gtgtcagtcg ttcgttcatc tttttgtctg ataaaattaa caaacttacg 1802521 ccttggctga tggctttctc tgcctgtgtg aacatgtcct ttaaaccgcg ttcaagatcc 1802581 tctgaaaaca gcacatcaat tttttggctt tttaaatcag gatgaacaat cgttttcaat 1802641 gcgtaaaact gttcattgga taaaacaggt gtatacagtt taatccggcg aacatttcgt 1802701 tcacttggat gaagaagatc gccttccgca ccgagccaag tcatcgttga agtgacaagc 1802761 tgctcacgaa tcgcgtcgat tggcgggttc gttacttgtg caaacagctg tttaaagtag 1802821 ttaaacagcg attgcgctcg gtcagaaagt acagcaagcg gagcgtcatt ccccattgaa 1802881 ccaaggggat ctttgccttc tttaataaca ggaattagat acttttggat atcctcatat 1802941 gtgtatccga atgccttctg gcgagtaaga agatcactaa attgttcttc ttctcttgac 1803001 tccggatcag gatttacttg tacaagctct tcttcaagcc atttttggta cggatactca 1803061 gttgcaattt gtgttttgac ttcctcatcg gagataatac ggccttcttc caggtcgatt 1803121 aaaagcattt tcccaggctc aaggcggttt ttatataaaa cgttctcctg ttcaacttca 1803181 ataacgccta cttcagatga gaaaataata taatcatctt ttgtgacata ataacgggcc 1803241 ggacggagac cgttccggtc aaggatcgcc ccgatttgtt taccgtcagt aaatgaaata 1803301 gctgtcggtc cgtcccaagg ctccatcagg gagctatggt actcgtagaa cgcccttttt 1803361 tccttggaca tatgcgtatt ttccgtccaa ggctctggaa tgagcatcat tgccgtatgt 1803421 gccggtttgc gtccagccat cacaaaaaac tcaaatgcgt tatccaaaat ggaagagtca 1803481 ctgccatcag cattgagaat cggcaaaatc ttgtttaagt cctcaccgaa gctttcagaa 1803541 acaaattgct gctcacgtgc tctcatccag ttgatatttc cgcgaagggt gttaatttca 1803601 ccgttgtgaa ccaaatagcg gttaggatgc gctctttccc atgtagggaa tgtattggta 1803661 ctgaagcgtg aatgaacaag cgcaaaagca gaaacgaatg cttcgtcttg cagatcagaa 1803721 taaaatgcat caacctgttc aggtgttaaa aggcctttgt aaacaatggt ctggcttgaa 1803781 agactggcaa aataaaaatc aagaccttcc gttactcccc aattttcagc ctgtttacga 1803841 atgacataca attttcgttc aaaagataaa ttgtccttta gatcagaact tgcgccgata 1803901 aatacctgac ggacaaacgg acagcttttt tgcgccactg ttccgatttt tccgacattt 1803961 acaggtacag ttctccatcc aagaacgact tggccttctt gttcaattag tgcattgatt 1804021 tgcttttcaa ttttttttct ttcatcttcc ttctgtgaga aaaagaccat tcctaccccg 1804081 taacgttctt tttctggcag attgatgttt ttgcactctt ttctaaagaa agcatcaggg 1804141 atttgaacca gtaagccggc tccgtctcct gtatccggat cactgccttg ccctcctcta 1804201 tggtctagct ggcaaagcat cttaagtcct tgtttgacaa tgtcgtgagt ctgcttgccc 1804261 tttaagtgtg catataggcc gattccgcat gcatcatgtt caaattcagg acggtagaga 1804321 ccttgagctt ttggcatttg attgtacgtc ataattcctc tcccccgatc aatttccgat 1804381 aataccggtc ataaaatcta acaactctat aatcattgta ggttttcaaa acgatataaa 1804441 caatatataa tttagatcaa aagaatctca aaatgagata gatggatgtg agacaaacat 1804501 ggagctgcgc caactgcgtt attttatgga ggtggctgaa agagaacacg tttcagaagc 1804561 cgctgatcat ttgcatgtgg cccaatcagc aatcagcaga caaattgcca atcttgaaga 1804621 agaattaaat gtgaccttat ttgagcgtga agggagaaat atcaaactca cgccaatcgg 1804681 aaaagaattt ttaattcatg tgaaaacggc gatgaaagcc attgattatg cgaaagagca 1804741 aattgatgag tatcttgacc cgcatcgcgg aacggtaaag atcggctttc ctacaagcct 1804801 cgccagccag cttttgccga ctgtcatttc agcgtttaaa gaagaatatc cgcacgtcga 1804861 atttttgctg cgccaaggct cctataagtt tctgattgaa gctgtcagaa accgcgatat 1804921 tgatctggcc ttattagggc cggtgccgac gaatttctct gacataacgg gaaaaatatt 1804981 atttactgaa aaaatttacg cgcttgttcc attaaatcat ccgcttgcta aacaaaaaac 1805041 ggttcattta atcgatttgc gcaacgacca atttgtattg ttcccggaag gatttgtact 1805101 tagagagatg gcaatcgata cttgcaaaca agcaggcttt gctcctctcg tttccacgga 1805161 gggtgaggat ttggatgcga tcaaagggtt agtgtccgca ggaatgggcg ttacccttct 1805221 gcctgaaagt acttttgctg aaacaacacc tcgttttact gtgaaaattc caattgagtt 1805281 ccctcaagta aaacggactg tcggaatcat taaaccgaaa aatagagagc ttgcgccttc 1805341 cgcgaatgat ttttatgagt ttgtcattca atttttctct aagctggagc agtatcaata 1805401 aaaaaaatga acccgagctt ctatatagaa gcttcgggtt tttttctgca aattaattta 1805461 caggtaaaga aaaatccaca tggcaaacaa atgcttcttg atcaattaga gctctatttg 1805521 tcagttcctt tttcttttcc ggttcttgaa gctgtacaga agagtaattg acgattccaa 1805581 ggccgatttc cgtccctttt gaatccatca gccgaacaac tgaaccgctt ttgaatttcc 1805641 ctttaatctt ctgtacaccg tctaggtata aactcgattg tccgtttgtt atttttcgtg 1805701 aacaatcatc tgataaaatc atttcacctt ccggaccgga attaaaagcg atccattgct 1805761 ccttttgatt caacggaagc gttccttctg cttcaaaata ggtgccttcc gcctgttcat 1805821 gaacggcgtg gtataaaata tcgccagcat ctgcctgacc taggaaacct ttaatgccag 1805881 acgccattac gattttaaac gcatcaagct tagagcgcat gccgccggtg ccaacgatgc 1805941 ttccagtgtc acctgcgcat gcttcgatgt caggtgttat ttcactcacc cgctgtatct 1806001 ttttcgcttc tggatttgtg cgcggattgc cgtcatataa tccgtctata tctgataaaa 1806061 tcacaagcat atctgcatca atcaatcctg cgacttttgc tgcgagcgta tcattgtcgc 1806121 caaacttgag ccgattgacg gtaactgtgt cattttcgtt tatgatcggg atgatgccgc 1806181 gctcgagcag tacattcatt gtattcctga cattgttgta tcgatattca tcagaaaaat 1806241 cgcttctcgt aattaaaatt tgggatgcga catagccgtg tgccaaaaac agctttgaat 1806301 aagcctccat tagcaatccc tggccgattg aagctgatgc ttgtttttct ggaagcttct 1806361 cgggcctttg gataaatccg agcttccgat atcccgccgc cactgcgcct gaggaaacca 1806421 aaatcacttc ataaccggcg tctttgagtt tgacgacctg gtcgaccaac gcttctaatt 1806481 ttcgaatgct gatttctcca tgaaggcttg ttaatgaact gcttccaatc ttcacaacga 1806541 ctcttttcat gcttgtatca ggcgtcactt tatcactcct gatagcggcg ctgcagtttt 1806601 ttcgatatct tcgctgattt cctttgaacg cttagccgca tgctttattg cttgagaaat 1806661 cgcttctccg ccgccgctct ttttcaaggc ttgcagcccc gctgctgtcg ttccgttcgg 1806721 tgacgtgata ttatctctta agatctcagg atgttctcct gtttccatga gcatttttgc 1806781 ggcacctaaa agtgtctgtg cgccgatgct tcgagataac tgtttatcga ggcccgcttc 1806841 ctcgcctgtc ttttcaatga attccattaa ataataaaaa tacgcgggtc cgctgcctgc 1806901 aattccggtg aatatatcca tttgattttc ttggattgta tagacttcgc ccatgcatcc 1806961 gagcaatgct tcggccagct tcttcaggtc ttccgacaca tatttgccaa gggcaatagc 1807021 tgttgcagaa gcgccaatca tactggaagt gttgggcatc actctgacaa ccggctgttc 1807081 attaagcaat gattgttcaa taaaagaggt agttatgccg gcaaggaccg acaatattaa 1807141 ttgatggggt tgaatacgtg attttagtga tgacagagcg ttttcggcgt cttttggctt 1807201 cattgccaaa atgagcacat ccatgtcttc aatacatagt tggttcggca aggcgccttt 1807261 aatgccatat tgaagttcaa gttcagttaa tcgctctgta ttgctgcggt ttgtaacgca 1807321 gatgttttgt ttcgggattt tgttggctcg aacgatacct gatatcattc cttccgccat 1807381 agatcctgct cctataaagg ctactttctt ttgatcaaag atcggtaaca tctcctttgt 1807441 tcgctttttt gttcgcattt tcacacgttt aaaatgttac cacgtgagga aatgatgtca 1807501 agtttgaagg ccattattga tttgtattgt ttcttttcga caaatatgta taatgaaaag 1807561 cagaaaacac ccggttcaca ctgctgcgcc gggtgtttgt ttctattaaa aattatctga 1807621 gagagctttt tcaatcagtt ttttacagcg atccagctct accttcagct gttttttata 1807681 tagcttggca gcttcgtaat ctttaaattg atagaggacg acttcctgga gcttagcccc 1807741 ttcttttttt actttaattt gttttagtat cccgtcatca agaagctcat gcaaagaccg 1807801 gtatacttct gtatgatttg gtttaaaacc aatctcttta aattcagacc gaagtacttc 1807861 aagcagcttt aacccataga gtctctcttg ctctgtcatc gttatcatat aaagcttcaa 1807921 aaatgcgcgc tgtttcacta aaaagcctgt tgaactcctt ttttcttctt tcatcatatg 1807981 cactccttct tctgtcactg acaacactat gtactaaata ttcaattttc ttttattgtt 1808041 ttccttcttt atattaaaga ctgatagtcc agttatttca tgtttactga ttataggtgt 1808101 agcggaaaaa ataaatttcg actgaacatt tggtacatag ttttcttagt tctattatag 1808161 cctgcattta ctgctatctt caatttaaac gattgccagg gtttacatat ctcattttac 1808221 cggtacggat ttcattcaaa taaaaaaacc tgtcgaaaga caggttttca tttttaagga 1808281 tttgttgacc ataatcccgc tgttttgatg aaaatacgag gatctaattt cagttgtgcc 1808341 accatgtact cagcaagatc ctcaggctgc ataacttttt caggattacc gtctgttaag 1808401 ttcaattcga tagacatatc actagcgaca gtgctcggcg ttaacgcgct gactctgata 1808461 ttatgttttc tcacttcttg cataagagac tctgttaacc cgagaacggc aaatttagaa 1808521 gcgctgtaag cacttgttac agcagctcct ctttggcccg ctgtagatga aatattaatg 1808581 atgtctccgg ctttgcgttc gatcatttcc ggaagcaccg cgcgagtgac atggtacaca 1808641 cccattaggt tgacttgaat aatattttcc cactcatcag ctgacagatc taagaaaccg 1808701 ccaaatttgc tgatgccggc attattaatg aggatatcga tatcaccgag ctgttccttc 1808761 acttgagcta cagcttggtt aacctgatcg gcatctttta catctgcagc agcaaatgca 1808821 gcttttacac caagcgcttt gacttcttca gccacttttt ctacattagc ggaagtccgg 1808881 ccaattaacc cgatattcac gccttctttg gcaagcgcca gagcagtagc gcggccaatt 1808941 cctctgcctc cgcctgtgat tagtgcagtt ttatgttgta aactttgcaa ttgaagcacc 1809001 ctttctttgt ttacatatgt acgatatcac attataagta caatacatcc aatacgcaaa 1809061 tcaaacgaac tgtgtaaata tcatttcttc tgattaaaaa aacggataca gggtaatgac 1809121 ataagaaaag gagtgaacat atgattatag tttatatcag tcttgcagta ttagcagttt 1809181 ctattatctt cttaggagtt accgtgatcc aaaacaagaa aaaaatagac cccgcactaa 1809241 aggagctttc ctctgttacg caggctatgc aaaaacaaat cgaaggatta aaaacagaaa 1809301 cagagctgct gacgcaaaaa caaaagaaga ttcagcagga tgtccaaata aaaaaataca 1809361 cgcttcagca gaccgcagct gaagtgaaag aagttcccca agcagtcaaa gaggtgtggc 1809421 aggcaggaca ttttaatagc agataaggat gaatgagatc ccgttgttac gatcagaatg 1809481 gacaaatggg atctcatttt tcgaggaggc ttacacatga ttataaaccg cagctgctta 1809541 aaagagttcg cagaaaaagt acattttctt ccctcttcac ttacaaagtc cgatttactt 1809601 actgatccat ttcgtctcca tcaagaaaac gaacttggca tctactattc acctcataat 1809661 gaatttatca atcgggatgc ctcgcttgtg attgccggga tcacgcctgg tttttcccag 1809721 atgaagacag cgtacgaaac agccgccgaa agcctgctgc aaggcgggac tcttgagcaa 1809781 atggcagtag acacaaaaat agcagcgggt ttctccggat cgatgagaca taaccttatt 1809841 accatgctgg atttatgcgg gctgccgcaa gcttttggca ttcaaagcgc cgcaaagctt 1809901 tttggagaat tacggcatat gctccataca acttccgtta ttaaatatcc tgtctttatc 1809961 cagcaaaaaa actataccgg atacaaaccg gctatcactc attctcctat cctaagcact 1810021 tatgcttttg ggcacttccc tgcagagctt aaccatgtga cgggaccagc tcttctcatt 1810081 ccgttaggaa aagcggccga aacagtgtgt gaaacattga tcagacagca cagcctccag 1810141 aatttgattt gccttaacgg ctttccccat ccatcaggcg cgaacggcca tcgtttgaaa 1810201 caattcagca aaaacaaaga gcaactagaa agacaaattc gttcctttgc tgcattggtt 1810261 gatttcgcta tagaaaagag gaaataaaag ggatatgata aacaaaaaca caaacgtggg 1810321 gagtggttga atgtttccta tattagaaac ggatcggctt atacttaggc aaatcacaga 1810381 tcaggatgcg gaagccattt ttgcttgttt ctcaaacgat gaggtgacac gctattatgg 1810441 gcttgaaaac atggaatcta tagaacaggc catttcaatg attcaaacgt ttgctgccct 1810501 ctatcaagaa aaacgcggta tacggtgggg aattgaaaga cgggacacta aagaactgat 1810561 cggaacaatt ggctttcacg ctctggccca aaagcatagg cgcgcggaaa tcggttatga 1810621 aatcatcccg gagcattggc gaaacggatt tgcatcagaa gtcatttcaa aggtcgtatc 1810681 ttacggattt tctgcccttg gactgtcgcg tattggcgca gttgtattta ccgataatga 1810741 agcatcaaat cgtctgcttc taaaaatggg gtttcaaaaa gaaggcgttt taagacagta 1810801 catgtatcaa aatgggactc catatgatac aaatgtgtac tctattgtga aaccaagaga 1810861 atgacggtat tctcttggtc tgtgccacat cccttttcct ttaaaaagat aaaaagcgcc 1810921 cctcaaacag ggcgctttct aattaagatg catattgagg agatgtttcc tccttaactg 1810981 ctttttcctc aggtatatga atacattttg tcaagaccgc acttgcaagg taaagggccg 1811041 caaagatcca gacgacacct tgcgcgccga cgagaccgat gaacagccaa gcgagtgcag 1811101 ggccgacaaa cgctgataaa cctgcagcta aattcaatac agacatggct gcccctttat 1811161 cttttcctgc caccgtcggc acaattgcac caatcggcac atagcctgcc agcaaaccgc 1811221 cccaaataaa gccgatcacg ctgacaaccg ctaaacttcc gccggagaaa acaggtgcgt 1811281 agtataataa gacggtgaaa atgccgcagc cgactccgcc gaaccaaata acagtatttt 1811341 tccagccgaa tttatcgccg acaataccga agataaggtt aaacacaatg ttccccagga 1811401 aaatcgttcc ccaaatttgc agccacacat tggttgaaat tccatgctgg gccatgtgca 1811461 tcggcaaaaa gactggaaaa ccatatgtac caatgctgtt gatgattctg atgattccgc 1811521 ctgtaagcac gcgcggattt gtaaatagaa tcgtaacccc ttttaaaagc tcctcggctg 1811581 tttctgatct ttttcttttc ttcttttcaa aacggtcttt attgataaac aatgcaaaga 1811641 atgcaccgag acatacccag aaaatagagc tccaaagcgt attcaaataa ccgaacgctt 1811701 tgatcgcgta gcttgagtac caagcgccga acacaaacat gccgaggcaa tatgcaatcc 1811761 aaaaccagcc gacagcagtg ctcagtttgc tttgcggtgt tctgtaaatg acccatgtca 1811821 agaaagaata agcaaaaagc gggtaaccta acccttttac gaagtaagtc acatacatca 1811881 ctggcaggtt cagctgttca aatccaaata cgataaaagc agctgtaccg atcacataaa 1811941 acaacagccc cataaacatc gttcgttttg cgccaaatgc ttcgagacat acacccgaaa 1812001 accaggaagc tatggcaagc gcaattccgt atatactaaa aatggaagcg gactgctgaa 1812061 cggtgagccc gttttcgatc aaaaaaggac tgagccagcc ttgttcaagg ccatctccca 1812121 tcataaacaa aacaacccct aaaaatcccc aggcaagccg cttcggtatt cctattttat 1812181 ccaacatatc tgtctcctcc ttagatgcta ttattcatta ccgtattacc ttattaaagt 1812241 tgaaaattaa atgattcctc aaaacagcag aaattccgtc ttaaattaat actttgcttt 1812301 ctgatcctga aaaaaagcgc tgtgtttgct tccattcctc atataaagcc aattctatct 1812361 gacagtcctt cggttcgatc acccggacat ttgctgacat ctcctccgtt aattgaaagg 1812421 tttcattgca aatgactgca gcaccgacga cagatgcctg atgatatccc tcttggacat 1812481 agaccttttt ttgaagaaga tccgcgatat attgagtgag cgctttgctt tggaatcccc 1812541 ctccgcacac ccaaacataa tcacgttcaa acggagtaac ctctgttaaa atgtcaaagt 1812601 tccatttgat tgaaaatgcg atctcttcta gcgctgcacg tacaaaatgt gccctcttta 1812661 aatgtgctga cagcggggca tcaaaaagaa aaccgcctct cgttaacgca ttcttttcag 1812721 ccgataaata agagccgaga gccgctacac atgcatggtc ttcttttgca agtgcagaaa 1812781 tctcctcctc cattacttcg tacgtttcat tcggataaaa aatctgtttt aatttttgat 1812841 aattcaagcc ggtaattccc ggattcgttt ccacaagcca atgcccttga tccgtatgac 1812901 agttcaacca ggctttatgt tttgtgtcgc catgatcctc agtaattttg gttattggcg 1812961 ttgttgtccc tgatacaatg acaatgtcct caagtccagc tccggtgctt ttgacagcca 1813021 gctgtgtatc cccgccccct gctataacct tagcatttat tgaaaggcct aattcggatg 1813081 catattcatt tgctatcgtt ccaattgctg ttcccgctct tacaagaggc ggaaggatag 1813141 atggagaaaa gccgaaaatg tcgcacatct cttctgacca agtgttttgc ttcacatcaa 1813201 atagcagggt ttctgttgcc tgtgatggtt catatgttaa tattccgctc agttggtacg 1813261 tcacccaatc actgatgctt gtaaagcttg cagtcttttc ccataaagag ggctggcgct 1813321 gttttaatcc ataaagcttg agcgcagaaa aaagtgcagt tggcaggcgg cctgtgctgc 1813381 tgtatatctc ttcccaatcg ggaatgcccg cctcccactc tcggccgcga ttatcgatgt 1813441 tcggcagccc gagaaaagga ttgccgtttt gatcaatcaa aacaatcccc tgtctttggc 1813501 tcgtcgatgt caaaccaatg atgtcaatat cacacgaacg ggatagcgca cgttttgcca 1813561 aattcatcac ctgcttccac agcacctgag gagaaaaata acggctgtcc gggtaaagcg 1813621 tctctgtgga atactcgatg tcctcccgtt caactgttag aacactgcca gttacactca 1813681 cgaccgctac cctcgcattg cctgtgccaa tatcaaaaac gagatagcct ttttgttttt 1813741 tcattctgtt agcctccttt cttatccccc tgttttcagt gcgtccttgt tatacattgt 1813801 ctgaatatta agagtttttt cacccttcca ctttttgagg gctttattca gtatcgtcac 1813861 gtgatgatcc tccacttcaa atgttgctcc agcgagatgc ggtgttgcca gaacattagg 1813921 caatgaaatc aattcataat ctgattcctc tggaggttca tgataaaaaa cgtctagtat 1813981 cgcaccgctg attttatgtt cttttaatac aaataaaaga tcttcacggt ttacaacaac 1814041 tgctcttgaa gtattaacga aaatcgcact ctctttcatc agatcaaaat attgccgatc 1814101 tatcagtccg agtgtttcct cagtgcgagg cagatggaca gaaacgatat cgctgtctga 1814161 aaacaccgtt ttaagagatg ctttttcata caacggatga tcgtcttgaa tgtatggatc 1814221 gtaatatttt atcttacagt caaacgcagt cagcagtttt gcaatccttt gcccgactgc 1814281 gccgaaccca atcatgccaa ccgtttttcc tgttagctca tttcctttaa atttgacata 1814341 agcctgcagg taatcactgt cccactctcc atccttcagc cactgattcg aggcgctggt 1814401 atggcgcaga aaggaaatca catttccaat aaacatttcg gcaacggctt gtgcattccg 1814461 ccctggtgta taaaaaacag gtatgcccct ttttgaggca gctgccacat ccacatttga 1814521 gggcattccc ctgcaaacac cgacaaatga aagttcggga acagaagcaa atacgctgtc 1814581 tgttacctga tcaagttcag taatcaagcc tgtcgcattt gttgctttta gcagctgaat 1814641 gagttcatcc tcccgatatg ccctaccttg ttccttccaa gattgataag caactgagcc 1814701 aaacaagttt tcaagctctt ttcgtccttc ttcgttgtac ggtgctgtaa ccaaaaccgt 1814761 catgctgcaa aacatccttt tcatcgtatt tttcataaaa aaaatctctt tccgaagatg 1814821 gaaagagatt catatatagg cgcgctctgt tacaggcaga cgccggtata aaccttgctt 1814881 tcctatcttt caagctagcg cttgctggaa ttggcacaat aatgttgccg aggtttcata 1814941 gggccagtcc ctccacctct ctggatagaa aatattgagt atgtaatttt cagaatgaag 1815001 aatacgttta tcataaagaa gactcagatt gatgtcaatc tctttttttc agaattgacg 1815061 ttatcatcgg aaatgttata attcttacaa aatatctaac tagagagagg aactgggcca 1815121 tgagatcttt tgccacacaa caaaacggca ttttcaaatc cgtttgctcg ctggactgcc 1815181 cggatcagtg cggattgtta atacataaaa aagacgggaa aatcgtaaaa gtgcaaggag 1815241 accctgatca tcctgtcaca gctggaaaca tatgcaacaa agtccggaat atgacggagc 1815301 gcatctatga tgaaaagcgg ctgactacac cgctcaaacg aacaggtgcg aaaggccaag 1815361 cgatatttga accgatttcc tggaaagagg caatcgatac gatcacctcc cgctggaaac 1815421 agctgattga tgaagaggga gctgaaagca tacttcctta cagcttttac ggaaatatgg 1815481 ggaaattgac agctgaagga atggaccgcc gcttttttta ccgcatgggg tcaagccagc 1815541 ttgaacggac gatttgcagc aaagcgggat ctgaaggcta taaatataca atgggcataa 1815601 gcgcgggaat cgatcctgag gaaaccgttc atacaaaact atttattttt tggggaatca 1815661 acgcggtcag cacaaatatg caccaaatta cgatcgccca aaaagcgcga aaaaaaggtg 1815721 ccaaaattgt cgtgatcgat gtgcataaaa atcaaacagg acgtcttgca gattggttta 1815781 tcccaataaa accgggaacc gacagtgcac ttgctcttgg catcatgcac attttattta 1815841 aagaaaacct tcatgatgaa gcatttctgt ccgagtacac ggttggctat gaagagctcc 1815901 gtgaacacgt gaaacaatat gatcctgaaa aggtatcgac gatcaccggt gtcagtaccg 1815961 aagatattta ccgactggca aaaatgtacg gggaaacctc cccttctttt atcagaatcg 1816021 gaaacggacc ccagcatcac gataacgggg ggatgattgt aaggacgatt gcctgtcttc 1816081 cggcgatcac cggccaatgg ctgcacacag ggggcggcgc aattaagcat aacagcggaa 1816141 ttttagaata taacacaaat gccttgcagc ggcccgactt attgaaaggg cgcaccccga 1816201 ggtcgtttaa tatgaatcag cttggcaggg tgcttttgga aacagacccg ccgattcgct 1816261 ctctatttat ttacggaacg aaccctgccg tcgtcgcgcc cgaagcaaac aaagtcagac 1816321 agggcttgct gcgggaagac ttgtttactg tggttcatga tttgttttta acggaaacgg 1816381 ctgcatatgc ggacattgta ctgcctgcaa catccgcttt tgaaaatact gatttttaca 1816441 cctcctactg gcaccattac attcagcttc agcagccggt gattgagaga tatggggaaa 1816501 gcaagtctaa cactgaggtt ttccgattac tggctgaagc catgggattc acagaccagg 1816561 agcttaaaga ttcagatgaa gtattaatcc gccaggcgct tgaccatcca gataatccgc 1816621 atttggcaga gattgattac gattcactta ctaagcattc atttatgaaa gcgaaacgtg 1816681 aaaagccgct gtttccgggc gaacttccaa cgccaagcgg aaaaatagaa ttatattcag 1816741 aaaaaatgaa acaagacggc ttccctgctt taccgacata tacacctctt gtaaccgata 1816801 atgaacatcc gtttatgtat gttccggggc caaaccataa tttcttaaac tcaacatttt 1816861 ccaataatga aaaacacatc aagcttgaaa agacgccaaa gctctttatc aacacaaaag 1816921 atgctgaaaa acacggaatc gttgatgggg cacctgtacg aatttggaac agccggggag 1816981 aatgcgagct gaccgctgca gttggagaac aagtgctgcc aggtgtcgtt gtcagccaag 1817041 gattatgggc ggatgaacaa ggaaaaaaac agcttgtaaa cgcgctaacc ccagatcgct 1817101 tgtccgatat gggcggcggc gccacctttt tttcaggccg tgtacagatt gaaaaggttt 1817161 gaaaaataat gaaacccgga gtatgccaag cccgtataac ataacatcga cataatggag 1817221 gcatacacat ggacgttttt ttaggaattg gtattgcttt ggctggatat tttatcggtg 1817281 aaggcttaaa gcagaggaac caaaccaaag gtaatgaaca aaatgatatc ttcctaataa 1817341 aagaacggga tatttacttt tacattggac tttttttagg aataacaacg actgaagcaa 1817401 aacagttagc tggagacatg gcagacctgc cttacatcga aataaacgga aaaaaatatg 1817461 tccagaaaca tatgttaaaa gattggacat tcacattagt tgaaaaacat cagggtgaat 1817521 aaaacaaatc tgaggagagc gagattcatt gtcacgctct cctctgttta gctgtatgga 1817581 tcctgccacc aaaactttgt gctataagcg ctgataaaac gataaaccac catctatgtt 1817641 ctttcctcaa acaactcaag atgcccgttc cacaacaata gtttttatat tcctttgatg 1817701 acgtgatgtt cttgatgaac gtatgtatcg taaaacactt agaaaaccta ttcggtttga 1817761 atgtgtgctc tcattatgcc cccatactgc gcctttatcc gcggaggatt tttttaaaaa 1817821 aatatgaaac ctaaagcttt tagatcctga atttttattg aacctccata tttctccgat 1817881 tggtaaaaat tagcctatac accggaagct gtacgtttat aaaggatcag agaatcccat 1817941 aaccagtaaa tcactgcagc cgcaatactt aacatataat aaaagtacga ttgcaatgtc 1818001 catgctattg acgcaggttc attgataaca aaaaacagga aagctgcgat aaaagcaacc 1818061 acactgtaaa tcaataggta catgacattg aaagttctcg cttttttctg caacttcatt 1818121 tggagcggaa cagcaaaaag gccatacacc acaaaaccgt ataataaagc aattgctgcc 1818181 gtaaacaatg caattatcat atcgccatac ataacgaaag aataaaaccc taataacaaa 1818241 ccaaatgtaa ggctggatag ccctaatgtc attaaataat atgatgcgat ttttttcatt 1818301 ttttcacccc ccttgtttga tttattcaca gtgctgttag tataaattca caacctttgt 1818361 atttctttta tcgagatgtc ttccctaacg tgctatacgc aatgcgctaa taaaaggttt 1818421 caaaaatgac gttcttttat tagataatac gctggctgaa aacgcctctc ctgattggcc 1818481 aaagcgcgaa tgaaaaaagt gcatgaatac ctgcccaaca gacagaataa gaagagttga 1818541 tatttcaaca cttttcgtaa aggggtgaaa ccaatgagta agaaaggtat tcaaaattca 1818601 agtattgaac aaataagaaa tgaccatgag actgaaacag cttttaaagc agatgatcct 1818661 aaaaaacacg gttccgatcc taaaagaacg aaataagttc ttacccccac taaaatatca 1818721 ataatctgga ggaagtaaag tgactcaaaa aaacggtgca gacagacctg atgattataa 1818781 aagattttct tcattagaca aggaatatga ttttcagcaa tctatacgca gcaatactga 1818841 gacagaaagt gtaaacactg aaacacaaac tcataacaaa gaaaacaaaa atgacacaac 1818901 agatgttgcc gggaaatact ttgagccctc agattataaa ggaagcacgc aattagaaaa 1818961 aggattggct gaaactcatg aacaggtcag cgatgactat tttgaaggga caatcgatca 1819021 aaatttggac tagccataca aacggaacta acttaaaaga agtcagttaa ctctgttttt 1819081 agaaacaacc acagtaaaag tagccaaccc ccaccgaata agatgggggt tgcacgtaag 1819141 tagcctgttt aatatttaaa acgattaatg acggtttgaa gttcttctgc caactgagat 1819201 agagattctg cggcatagga gatttccccc attgaatgaa gctgttcctg tgatgaattt 1819261 gcaaccgctt ctgtatttgc tgacgtttct tttgtaccag cagccaatgt atgaactgtg 1819321 tgctgaatca cttcaacgcc tgaagtaagc tgttgagttg ctgctgcaac ttcttgtatt 1819381 tgagaagtga cctgttccac caggttcagt atttcattga aatttcctgt tgtctcttga 1819441 gaaagaacaa tacctgagct cacattttct tgaacaactt taatattatt taccgtttct 1819501 atcgattcgt tttggatggt cgctaccacc gattggatgt ggtttgcaga tttatttgtt 1819561 tcatccgcca acttccgaac ttcttctgcc accacagcaa atccttttcc ttgctctccg 1819621 gctctggccg cctcgatcgc tgcatttagt gccaacaaat ttgtctgctc tgaaatcgtc 1819681 gtgataagcg aagagatatc gctgatttct gctgtgctcg ctaccaatgt ttgcaatcca 1819741 ttgccggctg aatctacaga tttatcaatg aatttcatct ggtctaacat cttgttgacg 1819801 gacttagagc ctatttcagc cttgtctctc atcgaagaag aaagatccgc tatgttccct 1819861 gtatttgaag cgactgatga tatactgtct aataattcag tgatggattc tgcgctcttt 1819921 tctgtcattg agctttgctt cacattgctg tcggcagcca tctgcatggc tcgtgaaata 1819981 tgttcagatg ttgatttcga ttcttccgcg cttgccgata attcttcaga ggaagcggcg 1820041 acttgttcag atgagctgct gatctgcttc acaatttgag ttaatgaatg agtaaaagaa 1820101 ttaaaagatt gggcaagctg gccaaattca tctttatttt tcacaatgac ttttttggtt 1820161 aaatcagcct cgccgtgtgc aatttcctcc agctgcttat ttatgcttct tagtggcacc 1820221 ataatggact ttaacagcat tatgcttaga acaatgccta atattactga tatccctgtg 1820281 acaatgataa tgagcgattg actcattttc ccattgccct gtatttcatc ctttagatcc 1820341 tctacctctt gatccaggcg atcagacagc ttattgacag ccggagctac gccttctttt 1820401 cttattgttc tttcttctcc aaaatggatg gtttctgctt ttttaggatt tgaagagtag 1820461 gctgttacta cttgctgatt caaagctcta tactgagtaa aacttgtctt aatgtcttca 1820521 atattggatt gatacttctc ttcatcaatc aagtcattaa cccggtcaag gctctttaag 1820581 acatcgtctg cttttccctt cataccctcg tcgtattctt tgtctctggt aatcaagaag 1820641 cctctttcat catttgataa cccggtcaat tcatattgga tgtgttttat ctctttttgg 1820701 aattccattt tgtctttaag ttcttcattc tttttcacag tagaagaaat cataaatact 1820761 gaggagcctc caattccaat aattgaaaca actaatattg atataatccc cagcaatttt 1820821 gttttcactt tcatgtgtcg ttttcccttt ccgcacaatg taatggctga aataaaatat 1820881 gttcaagcgc gtttgaatcc aattcgctta cgctcatgtc cataatatcg acacgtgtta 1820941 tcaagtttta tagtgatatt cttatatgaa taagcaaatt ctttacgtct ctgaacttac 1821001 agaaaaacct taagtaaaat ttgcagtctt ttgcggtatg taagtcactc ttattcgttt 1821061 ttctaaaaaa ggcttttccc acctcaaatt ggctgaaccg gctgttttct cgaaaatata 1821121 atacaatacg cagcataata tgaaggagcg aaacttaaat ggggatcatc aatggtaaag 1821181 aattcattga ccgattgaat aaactagaaa acgaaatatg gtatgatggc gaaaaaataa 1821241 agggtaacat ttctgagcat cctgcattta aaggaataat caaaacaaaa agctcacttt 1821301 atgaattgca aacaaaggat gagttaatac atgaaatgac ttattgcctt cctggagatc 1821361 ataatcgaat cggcctttcc tatctccagc ctaaaacaaa aaatgatttg aaaaaaagaa 1821421 ggaccatgat tgaacattgg gctagacata ctcatggaat gatggggaga agtccggatt 1821481 acatgaatac ggttatgatg agctttgctt cgtcagcgga gcttctaaaa gataaagaga 1821541 attgctttcc tgaacatata ctagatatgt atgaacaagc tgctaagcat gacctttcct 1821601 ttacccatac attcattact ccgcaagtga accggtcaca gtcctatttt gggctaagtg 1821661 aaaaaccgat atctgctaaa gtcattgata gaaccgaaaa aggtttaatg attcatggcg 1821721 cacgactgct tgccacacaa ggcgggttga ccgatgaaat cttggttttt tcagcgccta 1821781 aatttttctt tgaaacagat gaagcttatg ctttttcaat cccttctaat acaaaaggcg 1821841 taaaattcat cacaagagaa tcatttgtat taagcgactc ttcctttaat catcccttaa 1821901 gctcaaggta tgaagaaatg gattcaattg tggtttttga tcatgtgtta gtgccgtgga 1821961 atcgtgtgtt tttttacgat aatgtggaag cagctaaaga ttttatgaca aaaagctctt 1822021 ttcatgcctt tacctttcac caggttgtca ttaggcaaat gataaaaatt gaatttctat 1822081 taggtgttgc acagcttctt gtcgacacca ttaatgtttc cgaatatcag cacatccaag 1822141 aaaagctctc agaaatcatt gtgggattgg aaacaatcaa agccctcatt gacaaatcgg 1822201 aaaatgatgc tcagttagat gaattcggct atatgcgccc ctgtttaatt cctcttcaag 1822261 tcatcagtac gatcattcct aagctatatc ctcgatttac tgaaatcata caattaattg 1822321 gagctagcgg aatggtgaca ctgcctaccg aaaatgcatt tgactcagag atacgggaag 1822381 atcttgacca atatcttcaa gcaaccaata caaatgctga agaacgtgtg aaaattttcc 1822441 gtttggcatg ggatttaaca atgagttcat tcggaactag acaaactcac tacgaaagat 1822501 attttttcgg agatcctatt cggatttcaa gcaggctgta taccagttat ccaaagcagg 1822561 agcagttgaa catgattaaa acatttttac atgcagatac agaacattga aaaaacagcg 1822621 ggaaaagatc cgctgtttcg tattttttat tcaggaaact gaacatggcc cggtactgta 1822681 taggctttgg acgttccgct ttcaggcagc tttggaatgg tgtctttcac aacttttccg 1822741 cggatgtcag tcattctgac tttgagagag ccagtaccta aattcgtact cacaaaatgg 1822801 ttatagtcca ttttctccat gttgatccac ttaccatcct tttcatattc cattttcata 1822861 acaggatact tgtgatttct gacttggatt gctgcccacc acctgctgct gccttctttg 1822921 atccggtacg tgaaattgcc ggtgattggg gctttgacaa cacgccattt aatattgatt 1822981 tttccgtctt tcatattgcc gattttacgg aaggcattag gtgacagatc aagagctccc 1823041 cgagcgcctt cgggataaag atcagtaaca tatacggttg ttttcccttt tggcccttca 1823101 acttccaaat aagagccggc aagtgccgct tttactcctc cgtaattgag atccgccgga 1823161 tttattgcag taatctccat atcggaagga atgggatcca gcaggaaagc tcctcctgaa 1823221 tagcctgacc ctgtatacgt tgcataacct tcatgcaggt cgtcatatgc tgccgaagct 1823281 tgcggggaaa aacagaagat cgtcaacaaa accataccaa caaatgcact catgatcttt 1823341 ttcatatttg gtcctcctca aaccagactt caaatgagaa tcattatcat tataagactc 1823401 aatccatctg gtttgaaaga ggaaatagat tcatagttga ttttaaggca aattcactat 1823461 cattcatata tcaaatgtag gtacttatga aaaagccaat acaaatgaac gaatgtgcac 1823521 ttcagccgaa tgtcttattt ttccctctca aaattcgcat ttcaataacg aaatgaaaca 1823581 ggctgttggc ctgataacag ctatacagga aaagctattt ttccccgctc agtttcaact 1823641 tagctgtcat catgatgcca aagatcagca caatcggaac ccaaataatg aagtgataaa 1823701 aatcaggctc agccagagca acaataatag cccctacaca atacaaaata atagccagtg 1823761 ctcttaacac agtatctctt aagaaagtct tcttttgctt cttaaaaaac aaacggccgg 1823821 atatatcctc taaaagagaa gccaaagtgc cggtcaacac agttgaagaa atacctgcaa 1823881 tccccagttt ttttgctgct gtagtttgaa tccccataga aatgctcatg agtataatta 1823941 gaatgtgcac aggaacaaat gcccggtaaa aagaaagaca agcaaagaca aacaaaatga 1824001 atgcttcaag tgcgagggct tttgtcacag cagaaggcca aagggtattt tccgcctttc 1824061 cgaccatcaa tgtagcaatg atcacgccgc atataaatcc gattagcgca gtcaaggaat 1824121 taaaaacagt gacctgaatg gatttgccga tagctaaccc caataataca atgtttccag 1824181 tcatattagc tgtgaacaca tgtcccaggc ttaaataccc gattacatcc acgattccag 1824241 ctgttaaaca taaaagtgat agcaaggtgt ttcgataagc tgctgcagtc aacggtgtat 1824301 caatcctttc ttctatttca attgttagta tgtcttttgg cgcaatctct attttttaag 1824361 taacccaaca ttaattagga agatagaacc tattattcct ttccattaac tgtaataata 1824421 atccccgcaa ggaaatgatt aaaattgaaa ggaagcatat tgtgatgaaa cgactttgtt 1824481 tatggttcac cgtctttagc ttgtttttgg ttctcttgcc tggaaaagca ttaggtgcag 1824541 tcgattttcc gaatacctca acaaatggcc ttttaggttt tgccggaaat gccaaaaatg 1824601 aaaaaggcat ctctaaaacg ggcacaacgg gtggaaaaaa cgggcagatt gtttacattc 1824661 aaagcgtaaa tgatttaaaa acccatctag gaggatccac tccgaaaatt ttagtgcttc 1824721 aaaatgatct ttccgcatct gcgaaaacaa cagttaccat tggctcaaat aaaacactcg 1824781 tgggctctta cgcgaaaaaa acgctgaaaa atatttattt aacaacttca tcagcttttg 1824841 gaaatgtcat ttttcaaaat ttaacgtttg aacacagtcc gcagattaac ggaaataatg 1824901 atatccagct ttatttagat tccggtatga actattggat tgatcacgtc acattctcag 1824961 gtcatagcta taatgcaagc ggaagcgatt tggacaaact cgtgtatatc ggaaaatccg 1825021 cagattatat cacgatcagc aactcaaaat ttgcgaatca taaatacggt ttgattttag 1825081 gatacccgga tgattctcag catcaatatg acggctaccc ccacatgaca atcgccaata 1825141 attattttga gaacttgtat gttagaggcc caggtctgat gagatacggt tactttcatg 1825201 ttaaaaacaa ttacagcaat aattttaacc aggcgattac aattgctaca aaagcaaaaa 1825261 tatattccga atataattac tttgggaaag gcagtgaaaa aggcggcatc cttgacgaca 1825321 agggcactgg ttatttcaaa gacataggca gctatccatc actcaacaag caaacctctc 1825381 cgctgacttc ttggaatcct gggtcaaact atagctatcg tgtccaaacg ccggaatata 1825441 caaaagaatt tgtcacgaaa tatgccggat cacaaagtac aactctggta tttggctact 1825501 gatataaaag aggccctgcg ttaaaaacgc tgtgcctctt tttatactat aggctatttt 1825561 taagcgatcc ttgtaattcc atcaagatcc agcgtcggtc aaactaaaaa gcatatgttc 1825621 ttttccacaa taacttctta actggctttc ttattatacc agtttatcgc aagtgaaaag 1825681 aaatcattgt tctgaacctg tattaaatga acgatcgtcc cacaaactac ttaaaaaccc 1825741 ctaaaaagga tgatggatat gtgcggcagg tttactttgt actctgcatt tgatgatatt 1825801 attgaccagt ttgacatcga tcaatttttt cctaaaggtg aataccagcc aagctataat 1825861 gtcgcaccat cacaaaacat ccttgcaatc atcaatgatg gatcaaataa tcgcttaggc 1825921 aagcttagat ggggacttat tccaccttgg gcaaaagatg aaaagatcgg ttataaaatg 1825981 atcaatgctc gagccgaaac aattaccgag aaaccggcct ttcgaagacc gcttgtcagc 1826041 aaacgctgca tcataccagc agacagtttt tatgaatgga aacggcttga ttccaaaacc 1826101 aaaatcccaa tgcggatcaa attgaaatca tctgctcttt ttgcgtttgc tggcttatat 1826161 gaaaagtgga gcacacatca aggataccct ctttatacct gcaccatcat aacaactgag 1826221 cctaatgagt tcatgaaaga tatacacgac cgaatgccgg ttatattggc ccatgatcat 1826281 gaaaaggagt ggcttaaccc caaaaataca agccctgatt atctgcaaag tttgctgctg 1826341 ccttatgatg ctgatgacat ggaagcatac caggtttcat cattagtaaa ttcacccaaa 1826401 aataattcag ctgagcttct tgatgcagaa aatcatatgt agtgattgaa aaaattctct 1826461 agcaagaact tgtcaaatag ctttgttcct taggtgccaa tccctctagt aattatgaat 1826521 atttagtaca tagatcaatt agttatcttt agcatcagtt tgaaataatt ttattatgta 1826581 aacttaaata agcaatgtta ttcctttcat ataaaatagt ttacattttt ataaaatcgc 1826641 ttcacttttc tattttgtca gcaaaaaaac tgaaccacat taaacttatg aaacctgccg 1826701 cacctgtgga ttgcaaatat gatataagcc catagaggta aatccataca ctttccctcc 1826761 taagaattaa atgaaatttc tttcatctta catgaaggtc ttctttcttt tgtttatcca 1826821 gtgtaatact taataatatg ttgatgaatg cagctggaaa atatataaat cccactccaa 1826881 gaatgcctag tatcgtactt aaacttacta tgtaattctt tgtcatcgtt tgactgtcaa 1826941 tcaatattag aagtgaaatc aatccagcta aaacacctat aaaccaagca tcgccaacag 1827001 cataagaatc atccagcatc cctaaccatc gccccaatat agagctccca atggcagtca 1827061 aactggataa aaatatgagt gctttcattt cttctcctcc tttaaagcca atcaaactgg 1827121 tagaaatcgg ccattgaatc cccattatcg aatggttacc atttcatttc cacattaaca 1827181 ttttaaagct cattacaata cgattcaagc agaaaaaccc tacataacgt atatataggg 1827241 atttaataaa acacaggcca aaattcagct ctatctactt taaaaagata tgaagggcag 1827301 ctgtgtgatc tgttacgtct ttacgtaccg ggatatttca caacaggcac tttcttcttg 1827361 cgcagagaat caagcatgac tgatccagca ttcaagttgc tttgtactaa ttctttaggc 1827421 gtcaatgcca tccactgatt gagtgacaca tctgcatagc ggttactttt gaacatttct 1827481 aaaaaccata atgtttctgt accagtgttt tgtatatagt gtccggcatt agaaggcacg 1827541 tatccaacgt cgcctgctct ataatcaaat gtgcgggcag tcccatttcc gataaatacc 1827601 gtcattcgtc cctgtcctgt tagataatat tgccactcat cgctattggg atgccaatga 1827661 agctctctca tcgcgccagg ctcaatctga acaagtgcag cggctatcgt ttttgaaatt 1827721 gggaagttag aagaatccac aattcgtaca ctcccccctg gcatttgaat tgggggttga 1827781 tttaacagct cgtgtttaaa ggtcatgggg acttttccat atggtgactg aatgtcttca 1827841 ctggcgactg atcccggcac attcccttgg tagatataga cttgctcaga cggaagagag 1827901 ttgaaagcat tctccgggac accgaaattt gcagacagaa catcttttgg tgtgtgtgca 1827961 agccaatctg aaatggttaa cgttgaaaac tcagaaaagt tcccatcatc gaaaacgagc 1828021 agaaactcgc agtgttccaa tccctgtatg gaatgcggaa ttcctgccgg gaagtaccaa 1828081 aggtcgccgg gaccaacatc agcaatgaaa tttcgtccgt cttggtcaac agcggtgata 1828141 cgtgcccgtc ccaaaagcat ataagcccac tccgcttgct tatgccaatg aagctcgcgg 1828201 acgcctcccg cagttaagct catgtttaca cctgcaatcg cagtcgaaat cggaagctgt 1828261 cttacggtga tttctcttga ccagccgccg tgatctaatt tcatgggagc gtctgagaat 1828321 gaaaatctca agttaggaat cataccctca tctgtaacag gcggaacaaa tatattcgga 1828381 ttttgaatat cccgtattat atttcgcggg cctgtatcaa tagctccagc tccatcactt 1828441 cgaataggct gcggcacgtt tctgtcttca tgattgattg gttgttgttc caacagcatg 1828501 cacctcgttt tagaaatgaa caagatttta tttcagccta tgcagaatct tagattgctg 1828561 tgcctaggaa tccgcaaata aaaaagtgac caccaatgtg atcacaaata catcaaataa 1828621 actatttttt ataccatggc ttcttatgta atttgattgc ttctgtctgt tttttctggc 1828681 ctgtcctcca ctccactttt actaatacat catgacctat cacttcatct tcaggcatat 1828741 aatcaaaggt ggaaatatgg tcctccatgc gtcccccacc cggcatttca tcacctgtgt 1828801 actccgataa gtcgtactca tctacgttat catcttgata cttttcgcca tctacataca 1828861 gagtaattct ttcaacaaca gtccactttt cttccttctt actcccctgc caatatagat 1828921 ttagaaaata attgggtcca attgaagttt tgtctgattt ttcaaggtta gacatccaca 1828981 gtccgctttt cccgctgccc tcatatttca ctttgttccc tgacaccatt acaaataatg 1829041 tgatgatgca gatgatcaag aatccagcaa tgatcaatag ccatttctta atattgttct 1829101 tttttctcat gtttttcctc actttcctaa ctttttagta ggaaaatacg atcaaaatgt 1829161 taccgaaaag aaaataagaa agggctaatg atctaacaga tgactgtcta aacttttgac 1829221 ttaaattaaa gtgctttcta aagacaagat taaaacgtat aacagctctt aaatgcattt 1829281 tttgtttcat tgagtcaaga accttaaaat ggctttttat tattaaaaat caagctagtg 1829341 tattaagtaa cttttcaaat ttatttatac tcatgatctc gtgagtcaca aatctcccat 1829401 caaaaaaaac gctaaaagtt gtccaaatag ctggtgactt ttgtgcctct tctttcgatg 1829461 ataactgaat tgactgaaat tgaacccctt tcttttcagt caattcccgc aaatcattta 1829521 tcatgcccac tgcaaacgga cactgagctg tatagtatat cgtaatcccc ttttcattga 1829581 tagaatcact tttcacctgg ctcttaaatg caggagaatc tgcaaggcca ttccaagtca 1829641 aagccattaa ttgaaaataa ggggcagctt catcttgtag agtaaacccc atatgctcaa 1829701 agaaatgctt atcacttaaa tagggcagtt ttttcttgcc tgcgatatgg ataatgccat 1829761 ccatgccgca cgctttcgca tctgctatac atttgtccaa caatcgtttc gcatgaccgt 1829821 tatttttata tctgccagac acccacagac aattaatgta cataaaatta ggcgcattga 1829881 taggcaccca tgcctcattc gcaggtaggt attcaataaa gacttttgcc cgttcatgta 1829941 agcgatagaa caccaatcct tcatccattc gagctttgag ccatctcttc ttttcattaa 1830001 ctgcatgctc atattgtttc gtgcttaatg cacagcaaat atgattgtct tcaatattgt 1830061 cctttgtgat ttcaatgtag cacatctcct ctttcccccc tttaacataa ttacatggaa 1830121 ttcaacttca cactttacat gcctaataga ataaataccc gttccaactt aaatactttt 1830181 tcttttccat tttgccaatt aactgtaaaa cccttctttt attcagatat tatcttgatt 1830241 cctatatcac ccatttcaaa tccaaagtgt gttcatcttt gaggattaga tgcactgctt 1830301 atgctataaa tacagtacac gaagtttttt atttgaagta atatttgtta cgggacagca 1830361 atagtaaata agtgataaaa ggggaattaa acttggtgga aaaatgttat tcttgtttaa 1830421 tttgcggata caaaggatta attcaaaatc ctttgtataa aggcgagtat caaaaaacgt 1830481 ttgacatttg tccatgttgc ggttttgaat ttggctacag tgaggatcat gatgtgaggt 1830541 taggttttat tgtaactcct gatcatttaa ttgaggctgc atttcaattg tatcgcaaac 1830601 aatggcttga gagcgggatg gtaattgctc atccggaaga tattccagaa gaattgaaaa 1830661 atggcaattg cttaaaattt gaagttttgt tgaaacaatt gaaaaaacta aatcttgaca 1830721 tagaaaattt tgaaattagc ggtttttaat gatgaaacag gttgcacttg tttaggtttc 1830781 actgtcatta tcagtaaaat gttaagttga aatgcgcaat cagtcacaaa gtctctattc 1830841 gtattcaata aagactttgt gatcatcgac aaacatttca ctcccatcgg ataaagtatc 1830901 caaaaggcct cctctggttc ttctctatag tcattaatca cagtcacttt gacatttgac 1830961 tcagctatga ttggttttcc aacaattttt cgttttttcc tcaggcaaag taagagatcg 1831021 aatcatcaaa gccattccat ctttactgtc taattaacgc catcttcagt gaatttaaag 1831081 gtctgtttta aattgcgtcc ttcttgcccc ttctgtgtcc aaattataac aacctctaat 1831141 tcagaggcct tatctgccag cataaaatga ttgaacttca gcggtgagcc atcatttaaa 1831201 ctttcagcta acattttaga atcttctttt ggtttgacac aattttcatc gggacatcca 1831261 aaaagcgaaa accttgtgat tgaattaggg tcatttctat acaattgcac atccactgta 1831321 gctgcttttt cccctatatt tttgacttcc aaggaatata cttgatattc tcctttatga 1831381 ggtctcgtaa attcctttac attttttgct tcacttactt ttactgacca ctggtctgtt 1831441 ttttgtgtaa taggcaacac cgtaaaagtc agggcatgcg cttttgattg gcaaaacgta 1831501 aatccaactg ctgtaaaaac aattacagaa aataataccc ttttcacttc atttatccct 1831561 ccttcctttc actggccgct ccttaaagaa ttgattttga gcaatctaca agctctctta 1831621 accaaaacct tacctgaggt tttgtcttta ctgctctgca tttatttctt tcggtatccg 1831681 agaaggagct ttggggattt ttctcaatct gctgttaatc acatcagaag agtatagcgt 1831741 aataatcata cttcccccat acctttttgc ccgaattaag attggttggt tatattggtt 1831801 ttgaaagcga aagtcaggac ctccccagct taccgtcgca tcccgtccgg gcggtacata 1831861 tggtacactt ctagtatgag aatagcgctg aacgatctgc agtcctgcac gatctactgc 1831921 attaaataga gttgaggaca cctgacaaat tcctcctcct acaccttcag acaactcccc 1831981 ttttacaata atgggtgcac ttttatatcc tttgttccga gttctcattc ccacaacttg 1832041 gttaaacgaa aacgtctcat tagggaaaac aacgtgattg tcgattgctt ttgcagaaag 1832101 agaaatattg tgtgaacggc ttttattgct tgagttaaaa tacgtcacgt actgaccaag 1832161 ctgctgcgta ctgatgtgag ctagcagctc gctgtcaact ttcggataaa tgttcatttc 1832221 cggcacttct atcttggagg gaccttgccc ataaaaatac gcataaaact tttccataaa 1832281 cgcctgttga tacagtttgt agccaaccct gcccgggacg atgcttccat gatcgttaag 1832341 gacagcattt atcggctcac ggtacacttt ctgatcaagc tgtttgatga atttactgta 1832401 tttttcatag tcaaccattg gagtgccggg aagaggcatt gtaaagtctt cacggttaac 1832461 agtggcaatc gtccgtcctt gctgtgtgac cgttaaactg tcctgcggct cactcggctg 1832521 agccaataaa aaaagaccag tgatcaaaat ttgtatcata agtcggttta cctcccaatc 1832581 attagtatga acagccgctt atcctttgat gtatttcttc ccatcgtttg tttgaatctt 1832641 tagacgttga taaaaacctt cataaaagag cttagcttta tgttcacacc gatccctgag 1832701 ctcactgagg cacacggttc attcagtcgg caagtttgaa gtagttcagc atctcccagt 1832761 gatgagggat gcttttttgt cttgtcaaaa atgaaaaggg tctcctataa caacaaaaaa 1832821 tcaatccatt tcaatatttt tttattgaga aacgataaat tttttgttac attcaattag 1832881 acaacaaata aatgaggtgc ttgttatgaa tcgaatgtcg acaatttttt taaagatagc 1832941 tttggttctt attggaattc caattcttgc tttatgcatt tttttagtgc ctaaggtagc 1833001 caactattca gcagaattat ttccaaatat cgcttatata aaatatctcg ttttcatcta 1833061 tttgtatgta acggcgatac ctttttactt tgctctttat caagcgttca aacttttaag 1833121 ctatattgac aaaaacaaag ctttctcggg tttgtctgta agagctttga agaatataaa 1833181 atattgcgca gtcactatca gtatctttta cgcagcaggc atgcctgtct tttatctgat 1833241 ggccgagata gacgacgccc cgggtatcat tgtgatcgga ttggttatta tttttgcttc 1833301 aatggtgatt gcggtctttg ctgctgttct tcaaaaactg ttaaaagaag cgattgatat 1833361 aaaatcagaa aatgacttaa cggtctgagg tgatgacatg gcgattatta tcaacattga 1833421 tgtgatgctt gctaagagga aaatgagcgt aacagagctt tcagagagag ttggcatcac 1833481 catggctaat ctttcgatat taaaaaacgg aaaagcaaag gctattcgat tatcaacttt 1833541 agaagcgatt tgcaaggctt tagaatgtca gcccggggat atattggaat accgaagtga 1833601 tgaagacaca ggattcgtaa agaaaaaata tgaaggatca acagaaaaat aaagtgattg 1833661 gcggtgagct tatggacata aacttatatc catctagctg ctatactaag cgtccctttc 1833721 atacacgaag aacacaacta tggaggaggc atacatcatg agagccataa aacaaatcgt 1833781 ccattttggc tgggaacaag ccctttcatg tttgtttcct gccgttattt ttgcctcttt 1833841 ggctattacg caaatcatcc cactgccctt cttgccgcgg tatgactggc tgctcattat 1833901 ctgcgttctc atgcaattgt ggatggtgcg ttccggtctt gagacacggg atgaattaaa 1833961 agtgatcaca ttattccacc ttattgggct tgctctggaa ctttttaaag tccatatggg 1834021 ctcctggtct tatccagaag aaggatactc caaaatattt ggagtacctt tgtatagcgg 1834081 ctttatgtac gcaagtgtag ccagttattt gtgccaggca tggagaaggc ttaaggttga 1834141 actggttaag tggccgtctt tttttgcagt tgttccgctt gccgcagcga tttatttgaa 1834201 ttttttcacc caccattttt ctatagacat tcgatggtgg ttatcagggc ttgtcatcat 1834261 tgtcttttgg caaacatggg ttacatacga ggtgaatgga gctcgttacc gtatgccgct 1834321 cgcactttct tttatactca tcggattttt tatatggata gcggaaaata tcgctacgtt 1834381 ttttggagct tggaaatatc caaaccaaat cgatacatgg agtctcgtac accttggaaa 1834441 ggtaagttca tggctcttgc tagtgattgt tagctttctt atagtagcat cattaaaaca 1834501 agttaaggag cagagtccca caaaggcaga gatggatgaa tctttttctt agcatacgca 1834561 tacaagctcc caaatagagt gaaaagcaac gttcaaatgg ttgctttttt cttttatgta 1834621 actctgccgg tgagtattca tcttcttcaa atttcatcgc aacacgataa ctgattcaga 1834681 ttacaactgc tttcaacact ttgacaaact catgcgccgc cggcgttatc tcttcaaatg 1834741 aatgtgcgat gacgccaata tcgcgtgtga ccctaggaaa gatgtccttt ttaatcaatt 1834801 gatgcgggac ggatgaaagt gtaaagtttg aaatgatgcc gatacccaag ttatttttga 1834861 ccatattaat caaggtttcg gcattttgca cagttaagtt ttcctttaat tcgatgttgt 1834921 attgcgaaaa tgcgtttgac atcgcgattt catgaccgcc tttacaaaaa atgaggtcat 1834981 cttgatatgt ttcaaggtcg acatgctttt caagttttaa ttcgtcacgc tgcggcggga 1835041 tgacggccac catatagtcg ttacacaata gctgattttc aaacggttca aatggagatg 1835101 ctgcgatccc gatatcaacc gtccgatctt caacccatcc ttttatttgg tcagaggttc 1835161 cttcgatcaa ttctatgcgg atcagcgggt agtttgatct gaatgccgca atcgcctgtg 1835221 gcatgatatt tgttgaaact gcaggaaatg aaccaatttt caccttcccg tttaacagct 1835281 tgttttcccg gttggctact tgatatattt tgctttcaat tcccttcatt tgcctcgcca 1835341 gcagcaatat ttcttttccg atgtcagtca gcattaaacc atgatgttta tccctgatca 1835401 ataatttgag ctgcagtgag ctctccaggt tttttatcgc tttacttacc gccggctgag 1835461 agatgaacaa ttcttttgcc gcttctgtaa tatttaattt ctccccaact tttacaaata 1835521 tgtgaagatg gttcatgttc ataaccattt ggttataccc ccaataataa aaatgtattt 1835581 cagttataca taaatgtaac atatgataga aaccagcacg atattttaac aagaaaggcg 1835641 gcttcattat ggtaaaagtt atgctgggaa tcatatctgt cacacttatt tggggttata 1835701 cttgggttgc gatgaaagta ggaattcatg acatcccccc gcttttattt tcgggtttgc 1835761 gcctgttcat cggagcagtt cctttatttc tcattctctt catccaaaga aaaaagcttt 1835821 caattcaaaa agaacatctc aaaagctata tcatcatgag cctgttgatg gggctgggct 1835881 atatggggat tttgacgtat ggaatgcagt ttgtcgattc agggaaaacc tctgttttgg 1835941 tatatacaat gcctatattt gttacggtga tcagccattt ttcattaaac gagaaaatga 1836001 atgtgtataa aacgatggga ctggtctgcg gcctcttcgg actgttattt atatttggaa 1836061 aggaaatgct caatatcgat caaagcgctt tatttgggga gctgtgcgta cttgtggcag 1836121 cgcttagctg gggaatcgcg aatgtgttca gcaagctaca attcaagcat atcgatatta 1836181 ttcacatgaa tgcctggcac cttatgatgg gagccgtcat gttattggtg ttttccttta 1836241 tatttgaggc ggtcccttca gccgagtgga catatcaggc ggtgtggtca ttgctgttta 1836301 atggcttgct ttccaccggc tttacctttg tcgtatggtt ttgggtgctc aatcaaatcc 1836361 aagcgtcaaa agcatccatg gcattaatgt ttgttcccgt attggcccta ttctttggat 1836421 ggctgcaatt gcacgaacag atcaccatca atattatcct cggcgcactg ctgatatgct 1836481 gcgggatttt tatgaataca tttacatttt cacgacggaa agtgtgaatg atatacattt 1836541 cccctgtcat ttgggcttca tgtgacagga gaagactatt acgagaaagt cttctagaat 1836601 cctgacgaca gcctattaaa caatgaaaaa agctaatgtc tgcatgtaga cattagcttg 1836661 gctggcgttt aggctggtga gaatccagat acttttttat taccattctg gctgatcaaa 1836721 ctgaaaaccg tatagacctt ttactttaac atctccgcaa tctggatctt ttgtcaaaat 1836781 caaataatga gtcttataag gcatcgtctc aactcgatca gttgcactaa aatcaaaatg 1836841 atcccccgag aagttttttt cactaacggt tatttcatat cctgacaaag tcattcgcat 1836901 gattcttgcg ttaattgtac atccttcagt atcgaaaatg gtgaatctgt acccaaagtg 1836961 agatgtccaa tggtttgaat ttaggtcatc agacttcata aaccattttt cattctctgt 1837021 cattgtaaaa ctcactttct cctcatcttt cacgataacg gccgaagctt cccctacatg 1837081 gatagtcaaa gccaaaagaa atgtaaaagc taacatcaac atctttttca aaagagttcc 1837141 tcccgatatc ttttacttca atatattgga agggtctttt ctgatcaaga cagtcttctc 1837201 caaatgaatc tttagcacca tgaaatgagc cttaataaga acagttttaa cccaaatcaa 1837261 cctctattcg aaataaggct taccaatcta tattcttttt aaaagtttct gcatttcttt 1837321 atttagctcc tagacacata taaaaaatgc tcctataagt tcaggagcac tacaaaaaac 1837381 tgctaaagtg ttttctatcg atttattgta ttcattagct caaagaaata ttcaggcttt 1837441 tgagtcttat ttagcttata ccatgaacgc aatgtatctg gtgcaaatac atctaatttt 1837501 ttcaatactt ctaccgcaaa ttccagagga gcaattcctg atgcagtaac caaattttca 1837561 tcagatactg caggcccctt ttcatagaat gtttctcctt tgtaattagg gcagaccata 1837621 ttcatatagt cgaggtcatt gcttgtgtgc tttctcgaat ttaagtatcc ttcattcgcg 1837681 aggcccaagg ttgccccaca aattgcagca atagtcgtgc cgagctttaa agcgtcgcca 1837741 acttttttca agatcggctg atgaatatct tctccccaag tgtttcctcc gggtaaaatg 1837801 ataagatctt gactcccaag agtacattcg tcaagagaaa tatctggttt tatgcttaat 1837861 cctcccaacg tagttatcat ttctttatta acccctactg taactacttt taaagatgct 1837921 gcatcttgtt taaagtatct ccctgagttt agttccgcaa ttaaatatcc atattcccag 1837981 tctgacattg tgtgaaatac gtagagataa acttttctcg tttgcatcca ataacactcc 1838041 aatcacaatt gataaagctt tctaatagat gactttgctg acagtcattg tcagcttttt 1838101 tgttgattct attcttatgc ccttgttctc ccaacttata aaaatataag atcaattgat 1838161 tctatgttta ctagcgcaaa ggggtttgtt acactaactg tcatgggaaa catttcaaag 1838221 gtaatacaaa atcatttgaa tgaggaggcc tgatgaagtt gaaaactaaa gcgtcaataa 1838281 aattcggaat atgtgttggg cttttatgtt taagcattac tggtttcaca ccttttttca 1838341 actcaacaca tgccgaagca aaatccatag aagacacaaa catggcaagc tgtataacga 1838401 ataaaaaatt tgttcaactt gagaaaaaat ttgatgccag gcttggtgtt tatgcaattg 1838461 atataggttc aaacaagaca atcgcctatc ggccgaatga acgatttgct tacgcatcaa 1838521 cctataaagt tctagccgca gctgctgtcc tgaagaaaaa ctcaattgaa aaacttaatg 1838581 aagtcatcca ctacagcaag gacgatcttg ttacatattc tccaatcaca gagaaacacc 1838641 tagatacagg catgagccta aaagaaatct cggaagcggc tatccgttac agcgataata 1838701 ccgctgggaa catcttgttg caacagcttg gcggccctaa aggttttgaa aagtcactga 1838761 aacagattgg ggatcatgta acgaaagcta aacgattcga gacggatcta aactctgcga 1838821 ttcctggtga tattcgtgac accagcaccg caaaagcact ggcaaccgat cttaaagcct 1838881 tcactttaga taacactctc acgactgaca aacgcatgat cttaaccgat tggatgcgag 1838941 gcaatgctac tggtgacgaa ctgattcggg caggcgctcc aataggatgg gaagtcggcg 1839001 ataaatccgg agccggaagt tacgggacac gaaacgacat tgctatcgtt tggccgccaa 1839061 acagagctcc tattgttgtg gcaattctgt caaaccgctt tacgaaagat gctaattatg 1839121 ataatgctct tatcgctgag gctgcaaaag tcgtccttaa cgatctcaaa taatatgttt 1839181 agccttttgc cacaaaggaa aagacattac ttttttaact tctaccgttc attttttgat 1839241 gaacggttct ttcataagac ctctagaatc atatatttaa acaccacaaa attaaacatt 1839301 attataatta acagcaagtt ttcattttat ggaacaagta aagtttgaat ctgacaagaa 1839361 ttaagactaa gcaccctaaa atccgttttc ttttcttcca agaatatact ccttagtgca 1839421 agccattata aagatacaag tgaacataca atgcagacaa ctctcttaag tctcttattc 1839481 tgtgaccaat ttgtaatact catgaatatc cggactcact tccaatattt cgtctcgttc 1839541 gaagacacta acatatcaaa ccacttgaat taacataact gaacttgata ttggtcactg 1839601 gcagtttcaa tgcaatagaa caacatttgt tgtctcagag gttatctata tgagaattca 1839661 acaatttttt tataataatt catatttttg tatcgttgca cttggtggat ttgactcttt 1839721 tcgtgtatgg aaccacactt ttattttttc acctcttttg agatcatctg tgttatcaat 1839781 ctcacttaat cctacaatta ctatgttatt tttaaacttg ttcataagtt gtccttcaga 1839841 aagattgtaa tcttcttttc ctggagcttt tgtatcggta atgagaattg ccctttcatt 1839901 gtctttaagc acgacatagc ctactaggct ctgcatcttt gtttcgtctc cgttttgttc 1839961 atttttattg cagcctgcaa ggaaaataat gagcataatg agcactatca agcttactcc 1840021 gattttaggc atctttcttc ctcctcttta aactcatctt taaaataaac aacaggatat 1840081 cacccaaccc atctacttct ttttgcaatt cataacagca gcatactcat tctccaattc 1840141 ctcaaccttc tttttattct ttctcaaata tttgcatgtg gtagccctcg atattatccg 1840201 cttactcatt tttgcgcttt caaatatatt attgaaggcc gcttctttct ggattccagc 1840261 ataaatatac ttatccttac tgtcgtttac tatcgcaact tccattaaaa tcgagatttt 1840321 tacttttttt atgatccatt attcacttcc aaaataactt ccaattacaa cataatatat 1840381 gtataaattg taaatggagt tgatgtaatt gaagattagg aaaatcttat tgagttctgc 1840441 tttatccttt ggcatgctaa tatccgcggt tcccgcattg gctgctggca cttcgtctga 1840501 ggttgcagta aaaaatgaag aatatgatta tgacactata taccgcatta gtcctctgcc 1840561 aatggacttc cagccaacaa tagaatacaa cggttatact tatacgctta cacgtcatta 1840621 ttttgattac tcaatcgggt tttacacggc tatttataca aaagttgttt aaacttataa 1840681 aggagctttt tagctccttt ttctcttgtt ttaagcaagg tatttctttc tatgtggtcc 1840741 cctatcaaat acaacatcaa cattctccag ttctctttga cacgaacaaa atctaaagtt 1840801 tggttttaaa tgctggtaat aaaaaattca ctttaaagaa gtgccgcccg caaaatacgg 1840861 cttttgtaca ctacgccaat tttatattga aaagccagac ctcctcaaag aggttccagc 1840921 ttttcttaat gtgctatcga tcttcgttag ttcaacggga actttatcat tcggtacaaa 1840981 tgcagcctcc caacttctag ttagggctga tggcggaata tctgacggtt ctctacacac 1841041 atcagacatt agaagatttc aatgtagcct tctgtaccat gaacgcgaat tcgttgccca 1841101 tcttttatca gcttggcagc attttcaacg ccaacaactg caggtaagcc atattcacgg 1841161 gctataacag ctccatgggt catcagcccc ccaacttcgg tgactaggcc ttttatggat 1841221 acaaacaatg gtgtccagct tggatcggta aaggaggtaa ctaatatatc tccatcttct 1841281 aaatccgcat cttccatgtt taaaatgaca cgcgctcgcc cctctataac tccggaggaa 1841341 acaggtagac ctacaatcgc tccggctggg agattttctc gtttatactc acctgtaacg 1841401 atttcaccat cagacgtgat aacacgtggt ggagatagtt tttcatataa tgtgtactcg 1841461 tcttttcgtg tactgatgat ttgataatcc agtttatgtg tgcgcacgac ttcgtgaagt 1841521 tcttcaaaag tgagatagta tatatcttct ttttcatgaa taacgcccgc ttctatgagt 1841581 tgttcggctt ctttcagtaa agcctgctta taaacgaagt atcgattaac catgccgtat 1841641 tttggatatt ccctaaaccc gctgaaattc cggatgatat ctatcgctcg ttttgtttct 1841701 ttggcttttt gttcaccatc cggtaattgc ttcaatcgat ctaataactc ttgttctttc 1841761 ttcaaagctt cctgtcgccc ttgctcaaat ttccgatggc cgacattagg ctcaaaattt 1841821 ttaatattat taagaatcat tgggacaagt gtagttggtt tttcgctcca tcgagttctt 1841881 gtgatatcaa tctctccggt acatcgcatt ccgtatttgc tgagataatc atagatcgcg 1841941 tctcgggttt tgcttccgcc atcaaactta gccagttcat ccaaaaagtt atcatctttt 1842001 acatgttgta agtaatcaat tacctctgga taaggacgaa tcacatctgc gacgtctaat 1842061 agcgcaagac ccatttctga agtaatatta tggggtacag attgagaaag cgtatctgct 1842121 gcgttttttt cacctaacca ctcgttcatt ttttcgttaa tccataatga agcattcata 1842181 gcagttcgaa ttagaaccga actttttggg ttaaataaaa tcttctttaa ttcctgaata 1842241 tcttccagaa taaaacgaaa taaatctgat cctgatttcg tttggatgtt ttgttttaac 1842301 tcttctatcg atgtttgact gctctcaatc aaatcagaca cgattgtcgg atcgttttca 1842361 acttgagccg gcatatctgc attgcctctg ctgggatttg gtgctgtttt atcatttggt 1842421 atcgacttta tgaaatctcg tcgctttatt atggtcataa gtgcgtcttt taagagctga 1842481 tcgtgctgcc ccatgccttt taagaaaact tctctgctgt caggggatgc cagatgatgt 1842541 gtgacatcaa caaatagcct tccaccggct ttacgcatgg gtgcaacagt cgtcaacaga 1842601 aaaaaagaca atcccagtgg ttttatggga tccgtcatca tttgttgatg accaacagaa 1842661 atatagacgt gattttcttg gtcactcgct tcagggatgg ggaataaagt agtgattgga 1842721 cgactctgta caatataaaa agtatcgcgg gccaaacacc attcgatatc ttgcggctgg 1842781 ccgaaatgag cttcgatctg tcttccaatg cgtgccagct gtaaaatttg ttcatcagtc 1842841 agtgtttgag ccttttgctg atcagaatcg atctgctgtg tttctgttcc gccttctttt 1842901 cgtccgtaga tagccatttt tttagttgct attctcttat cgatgatttg cccatcctgt 1842961 actttaaaac aatcggcaga taccaagcca gaaaccagtg cttcaccaag tccaaaaccg 1843021 gcatcgatgg ataacacctt tcggttggag gtaatcggat cagcggtaaa taaaatcccc 1843081 gaagcctgag ggaaaaccat cctttgaacg ataacggata aatagacttg gctgtggtca 1843141 aatccatttt gcatacggta aataaccgcg cgatccgtaa atagggacgc ccagcattta 1843201 ctgatatgct gcaagattgc atcgacgccg gtaatattta aataggtgtc ttgttgaccg 1843261 gcaaaagaag catgtggtaa atcctcagca gtcgcactag aacgcacggc ataggcatgt 1843321 tcctcgccaa actgggagag atattgagcc actgctttca caacatcgga aggaatgtct 1843381 acttccataa tgatttgccg aatcttccgg ctgatgttac caatctgatc tcggtcctca 1843441 acttttagca tggtcaattg atccaacaac acttgtaacg tttcgttttg ttcgatggct 1843501 ttttgatatc ctactgttgt gacacaaaat ccttctggta cttgtatacc ttgaattttt 1843561 gataattccc ctaaatgtaa cccttttcct ccaacgagcg aaagctgtgt tttttcaatt 1843621 tcatgtaaac cgagaaccaa agaactcatt ctacatctcc ccttcaaaaa aaaatattga 1843681 caagagcttc ctagcaggat ataataaaat tataagatgg atatctataa ctttttaact 1843741 agaaagcgca cgtagtgtga ttatatcacc gtgtctgttt ttgtgcaata taaaaagaac 1843801 ctgggaaatt tcaccaggtt cttttcttaa tttccatagc tagtcgcatt aaaaaacttg 1843861 gtttgagctg attcaatcct ctaaggaaat cctaaagttg ggttcttttt gaacttactt 1843921 gctttgttcg tagagtcccc attcataaat tggacttttt gttcttaaca gtcccacctt 1843981 taactagtat aaagttatga ggatctggtt aactactaga tatttttatt ttgaataagg 1844041 cttatgtttg ataaagaagg gttatgtaaa ggtgtctgtt gtgagcaagc gctgactaca 1844101 aaaaattgat agcattctca tttaaatacc attctattaa cctataggga aagttttaaa 1844161 accagatgga gaatacccta cctccagcaa ttccaaggcc gttcacctag tagaaaacaa 1844221 cctttaacca ttactaacga ttttaataat cattgattat aaaacttctc aaggaacgat 1844281 cagcagcccg ttagctaccc ctgattaagg atgatctgtt accacactgt tacgttagaa 1844341 cttccactac tttgatatcc ttctgtcgcc atgacttggt aagcccaatt actgcccaga 1844401 ttcattccat ggctcttcca tgcgttcaca tgattgctga aagtgattgt agcgttgctt 1844461 ccggttggtc tcttcgactg gcgaacactc cagtactgcg taaaagtagt gcgatcgcca 1844521 tcaatggaag gtgcgttata acgtgtagtt gtatatatgt catatgtacc cccatcactt 1844581 tttacagtac ctttatacgt tccagtaggt ctataagtac cccatgaatc cactacataa 1844641 tattctatga gaggtgatct cgtccaacca tataaagtta aatatccatt gccattcggc 1844701 gcccaaactc cggcattata gtttatcgtc ctaaatggcg aacctgtagt ccaaccttta 1844761 ccaacaacaa aatttccggt attagaccaa ttaacactgt aattcccgcc agacccattg 1844821 acagcgttta ctataccgcc cccatcagtc caattttgcc agtagtctgt gctagctgca 1844881 gaggcggttg ccgaaaacaa gctaatactc attaaagctg ccgataatcc aactaagaaa 1844941 ttctttttaa acttaaacat atgttacctc ctataatatt ttttccgact ttgaggtagc 1845001 actcgtatac atttaaaaca ttcttaatta ctaacgccaa agcttttgat cgtccccttc 1845061 agtataatac cacgaattca tgagcaaata ttaaaagtat ttgtaattca attacaaata 1845121 cctagaaaca cattataagt ggtcttcttc caccatatcc tgatccgagc tcgatgtaca 1845181 tgcctttacg gcacacacga atgtggcgtg tggtgcatcg cctcaatacg caaagacgtt 1845241 tgccttaggc aaacgtcttt ttttgcgtta tccgattttt gtgccgtttg ggacaggctg 1845301 atccggctgc aaaaggacga cgtcgccctg gccgggtatg ccgccgagga ccaagacttc 1845361 cgatttaaat ccggcgatcc ggcggggcgg aaagttcacg actgctatga cttgcttgtt 1845421 gatgagacct tccggcttgt aacgcttcgt gatttgtgcg ctcgattgtt ttatgccgat 1845481 ttcagtccca aaatctatca caagcttgat tgccggtact cttgcttcag gaaattcttc 1845541 cgcttttaca attgttcccg ttctgatatc caatttctca aagtcatcaa taactgccat 1845601 atcaataact cctttttctc ctattgtaaa ggagatatac aatattcttt taactaaaga 1845661 gccatcattt tttatccgaa tataaggtgt ttcgatacag gcggggcggc attcctgtgc 1845721 ttttcgtgaa ccatcttgta aaagaagaaa ggttttgaaa gcccagcgcc tcgctcacga 1845781 cggtaagagt ttcatttctc tccatcagca ttctttttgc ttcctcaagg cgaaggtcgg 1845841 caatatagtt ctgcggggac ttccctgtct gttttttgaa ccagcttgaa tagtaagctg 1845901 ggtgataatg ctcgatttct gccagcttct taatcgtcag ccgctcaaat aaatggctgt 1845961 gaatgtatgc aattgaggca tagctatggg attgaagctt ttcttttatg tattgtacta 1846021 gcatatgaag cgagttggct gttccggcct ttgcttcctc tgtcagcaag tacctgatcg 1846081 aagaccagaa aggatcgagg gcagcttcaa ttcctgatcc tgcacgatac tcatcaattt 1846141 tcattgcatg aagcggaaca tccagtacaa gacattcatt tcttccgata gaacggaagc 1846201 gatgctcgca ctgcggcgga atatataaaa aatgatccgg atttaatttc acctggcgcc 1846261 cctcagtctc aagatcaata ctcccttcaa gcggaaaaag aaattggctg tacgcgtgct 1846321 tatgtgaatg atatagccgt gtgtatgtcc gtttttcgca aattatctct tgaagcgagt 1846381 ccattagcaa accccttcct ttggtcatct tttaatccgg taatggtgtt ccgatatagg 1846441 cgaaaagccg atttttccat ataaagaaac tgccgccaga ttttctttca tcacttgtaa 1846501 aaacatgcgt tccgctccgt tgttttttgc ccattcagtc aacaccctga tcacttgggt 1846561 tcctgcccct tttcctctgt gctcctcagc tacaacgata ttactaagtc cgccataacc 1846621 atcaatgaca gaaaccgtgc caagcgctgt caggctttct ttgtcataca tcttgaaaaa 1846681 agttttacac ggcggcatgc gttcgaatat gtgtttgtaa cctttgtgac gctcgggtga 1846741 aaacccttct aattgaataa attcatctat ccaaacagat gatggctctt gttcccactt 1846801 gtatgtaaat cggctgttgt catttgttcg gctcataatt gaccggcaca acgctgtcat 1846861 ctggaagcac tcgtctacct tttcataacg gctgtctgcc aatgcgtcat caagcccttt 1846921 cggtgatgcg ttgctaatat gaaaacaaac aggtaagcct aaactttgat aaaaaagttc 1846981 ggcctctagc tgaaaatccc cttcaggcat atccgcagac gtccatacgc tatttgccct 1847041 tttggttacg ccaaaattcg ctctgagaag ccatttccct atgctttttt gaaaataagc 1847101 cggccatgaa gctgccgcta atcgttcaat cttgcgaatg tcatccattg cataatgcct 1847161 ctcccctatg tatactccct tgatattata caatattcag aaatataaga catccattta 1847221 tttgtttaca taatattttt attgtttatt aataatcctg acaaaaatgt ccgaattgaa 1847281 aatgacaggc tttctaaaat gtcctcctca cgttcaaatg cttcttttgc gattaaaaca 1847341 gtaaagccat gcagcagact tctgagcccc cttgtcgcat gaatggcagt cttttcactt 1847401 gcatagccgt tttcaatgag cagcttcgtc acaagacaga caatttggtc agagacgatt 1847461 tccgtccgtt tgtcgtgaac cttaagaaga gccgcttcat aatatccggg attttcaatt 1847521 gcaaaatcaa catatgcatg agctaaagaa agcatcgcgg aatctccctt tcgttcggtt 1847581 acggagtccg ccatttgatc aaaaagcttt gtcagtcctc tgacagcaag ttctgctctg 1847641 atcgcttgca gcccgttgat atggttatac aatgacgggg ggcgaacatt cattttttta 1847701 gaaagtgcag caagtgagac accatttacc ccttcctgat cggcaatctc tgctgcagcg 1847761 tctacaatca ttttttgggt caaacctatt ctcggtgaca tgctcatcat cctttctttg 1847821 ctttttggat cgcctgtctc atccgctctg aaggtgatcg caggaatttt ccatgtccga 1847881 cagcgagaca ggaaggcgcc ttatcggcga gcaattgtgc acttttgatg gcctcctcct 1847941 tattccatgt ggcgaaagcg ggaaaaggaa acgcccattt tatctgacct gatacagcga 1848001 ttcctccgcg caactgaaac gcatctcctg ctattaaagt gccgtttctt gtatcaagaa 1848061 atgacatgct gcccggtgta tggcccggtg ttggaatggc aagcagagaa ccaattgttt 1848121 caccgcccgt cagcagttgg tgaggctttg tttgtatgtg tttcggaata cctcctttta 1848181 taggcgtctg cggctcatct tgccgcaaag atgtgtcacc ttggagcaag aatgaatccc 1848241 gttccgagat catgaccttt gcatgcggaa atgtttgtgc caatgtatcc agtgatccga 1848301 catggtcccc atgtgcatga gtcagtaaaa tatgctgaag cggttttcca agctgattca 1848361 cagcttgaat aatcccttta tagctgcctg gcagtgcggc atcaataagg gtgacttcgt 1848421 tttcttcctc tactaaatag caattaaccg gaaacaatgc tggaaaaaaa gtcagctgcc 1848481 aaaccgtttg gtactgagta attctcatct ttttattcct cctaacaaaa actaatggtg 1848541 ttagttttat tattaactaa caccattagt ttttcaagag tttattattt ttttatcgct 1848601 acataaatgt taacttgtgc tcgctgtggc actgcggcat tttgatcata catctcaaag 1848661 tcacctgtaa acgtgcgcag atgccgctta tcccaagtcc aaatttcctt ccacgtttca 1848721 agcacaatct cttcaatagg accgattctg gaagtgaaaa cggcgtaagc ggaagccggc 1848781 aaatcaatat tttcatatgg tcccggaaga atgtcgtcgt attcctgaaa cgttccgact 1848841 gaaaacgtat aaaacccatt cgtctcttgt tcataattcg aatataaggc aataatgctc 1848901 ttgtcttttt cagcctgtga taaaagagcg ctcatatcct gcttccataa ttgatcccac 1848961 agtgccggaa tcctcctttc ttccgtcatt tccagtgcgt tgcttgtccg ttgtgatagt 1849021 ccggcaaatc gtttcaggtc taagtgtgtt atatgtgaaa agcccatacg atctcctcct 1849081 ttttttaaga ttatagacaa agaaacctga cagcagtgtg tcaggtttca tatatttttt 1849141 gcatgtgatg aatggtttct tttactttat cccttatatg aagaggctgc agaacctcaa 1849201 tatcctttcc gaactggagc aaaaaaccga tcagccattg atcttctgga agtgaaatca 1849261 ccgcctggca gatttcatct tcctcacaac agtgaaggac atcatatccg aaccattcac 1849321 ctatacgctg acgtgctgac ggctgaacaa gaataaccaa ttcagttaaa cggtcctttt 1849381 ggtaccaact cttatcccat ggcaaagtgt ccagctgaat gtcttttctg ataaatgtct 1849441 gatgtaagat ggccagatct ttcatccggt tcagtttaaa aaagcgaaaa tcatttctta 1849501 ccaggcagta ggcatataaa taccagtgcc ccgccttgca aaccaatgta taaggttcag 1849561 tttcccgaag tagtgtttcc ccgcttgcgc ttgtatatgt aaaagatatc gttaacaacc 1849621 gatcgatggc agcgctgatt ttctcgcgca gcgtcttttg atcctcagta tggccccaag 1849681 ccgtcatgtc aataaaccat ttttctgttt ggtgcttaaa tgcttgagta gattgctcag 1849741 gtataaggtg tttgattttt tgataggctg tgctgtgaga aacgggttca tacatagatg 1849801 aaacgctttg caaagcggaa gcaattgcaa acaattcctc ctccttcagc cactctcttt 1849861 caagccgata cgtttccatg atgccaattc cgcccccgga accctgtgag gtcacaatcg 1849921 gaataccagc cctattgatc gtctcaatat cacggtaaat tgttctgaca gatacttcaa 1849981 acagctcagc aagctctgca gcctgcactt gttttttgct gatcaataac acaaccatcg 1850041 ctaacaaacg ttccagtttc attctgcgca ccttttcttc ttgtattttc caacaaaaca 1850101 atcataacat tttgataaag cttgggcata tctattatgc ggcggaatac acctcgcata 1850161 tgctatgaaa acaggggttt ccccttcttt tttgtgttca gtatttattt cagctactat 1850221 ttccgaccgg ataagcatac acttctcaac ggaggggatt tcacatcatg catcttacac 1850281 ttcagagcgt ttatcctgcc ataatcatca tcttttttct gtataaaaaa attaaaaggt 1850341 ccatcggata ccagccgctg aagccccgct ggctgttcac ccgtatcatt cttttctcgc 1850401 tgtttgcttt tggactttca atcttcagcg ccattcaccc ttttttatat ggatatctca 1850461 ttttgggcat tcttggcgga tggctccttg tctttttcgc taagaaaaac atctcttttg 1850521 aaaaacgcag aggaaagatc tattttcgga ctcatatttg ggtagaggtg attctcttaa 1850581 ctttatttct atcaagattt ctgtatcgag tgacggagct ttatcttacc tcacctgatc 1850641 taaaccgcct tggatcatac agtcagtcaa tcggaacgga ccctctgaca attggcgtct 1850701 gttttctgat agccgtttat tatatcggtt tttcttcttt tatcatcaag ctcagcagaa 1850761 acgaacttga acagcacgaa tacaataaag aaaaagacat ccttgcccgc taacagcgag 1850821 ttaagcaagg atgtcttttt caatcatgct gtgtatgatg gatcatttgc tgaagaacat 1850881 ctaaaacatg ttcatcctcc ggagagtaat aaatcgatgt tccttctctg cgcgatttga 1850941 caagccggag attttttaaa aatctaagct ggtgggacac agtggattgc agtaaattca 1851001 gcttttctgc aattccgttt actgcatgct caccttggga caataaatgg agaattctga 1851061 ttcgggtagg atctgaaagc gctttgaatg tttgcgcgac tagaaacagc gtctcctcgt 1851121 ccagatcagc agccgattgt tccgtttctc taaattcagt catatgtatc acctttcttt 1851181 attcatagtt ttatcttata acaaatgcgc ttgagtgcaa accagcctgc ttgtattcca 1851241 tttcaatctc atagtttaaa tttatgtttc aaatcaggtt tttacttggt ctgatatacc 1851301 ctcttatgtc ataataaaaa aggtcatact gctccaaaca ttgagggtga aacacagtga 1851361 agaaaaagag aaaaggctgt ttcgctgctg cgggttttat gatgattttt gtctttgtca 1851421 tcgcctcttt tttattggtc ctgctttttt tcaaccggga tttaatcaaa aaacttccga 1851481 tcgatacgaa aacgattgtt ttggaacgtt taaccgatta caaacccttg gtggaagaag 1851541 agcttgaaag ccaaggactc tctaattata catcactcat attaggcatg atgtatcagg 1851601 agtcaaaagg aaaaggcaat gatcccatgc agtcctctga atctctgggg ttaaaacgca 1851661 atgagataac agaccctcaa ctcagtgtta aacaaggcat caagcaattt accctcatgt 1851721 acaagaccgg taaggaaaaa ggcgtggatt tggataccat tattcaaagc tacaacatgg 1851781 gggcaggtta cattgatttt gtagctgaac atggaggaac gcatactgag gaattggcaa 1851841 aacaatactc cgagcagcaa gtcaaaaaaa atcctgatct gtatacttgc gggggaaatg 1851901 cgaaaaattt ccgctatccg tattgctacg gtgattatac gtatgcagaa aaagtaaaag 1851961 aaaaaacaaa aactgttgaa gaatctttgc aggttgcaac acttgaaacc atggaatcca 1852021 aggctcatga ataagagtct atcaatttac tgacaaaagc ccaaaaatga atttgggctt 1852081 ttgccatgtt tacacgtaaa aaaagccata ctgagtatgg cttttaataa tacggtgaaa 1852141 tcatcaaata tacaataacg cctgtaaggc ttacatacag ccatagaggc attgtccatc 1852201 tcgcaatttt tttatggcgc tccacctgca tgctgaagcc tctgatcagc gtaaacagcg 1852261 caagcggcac aataattgca gaaaggcaga tatgtgtaat taaaataaag aaataaatcg 1852321 ggcgcataat accttctccg ccatagagcg tgttttccgc aatcgagtgg tacgtcacat 1852381 agcaaatcaa aaatagtaat gttgttgtga acgcagccaa aataaagcgt ttgtgagctt 1852441 tgatattttt ctgtttaatc ataatcagcg cggccaataa gaagataaac gtaaagctat 1852501 tgaatatcgc attcagcatt ggcaaaatgt gaatattcgc atggctgaac tgatctaatt 1852561 taggcataaa aaacagcact gcgattaaac cgttaatcag aactgtcagc gtaaggacaa 1852621 tccccgtgta atttttcggt ttattttctg tttggttcat ttggtgacct ctcctaattt 1852681 gtactggcta tccaaatcgt atgcaaattc aaagaagatg tcaacggttt cgattgcttc 1852741 gtcagaaatt agacacactt caaaggccgg aggctattag ccccggcctg ttaggtttac 1852801 gcctctttta tcaaatgttc aatgacctta tgttcatttt cattcagcag gttcttttga 1852861 attttcgaat gaatgggttt attcatatgc tgatccaaga tatcggccgt ttctttatcc 1852921 ccggcaataa ccattcgttc ccatcttttc gcggcagctt tttgatcaag gctggcagcc 1852981 agccgcttat acagtctcga ttggttctct gttacatgtt ccctcatccg gttctcttca 1853041 aatggtggcg ctttgtctac agcggaatgg ctattcttcc aagactcatt gatcatatca 1853101 tactcataac gctccaccgc ctcaattttt cctaaaacag tttcaataat tttcacttca 1853161 tgctgctgag ttaaaataaa cgccgtactt gggtatgtct ggcgcaaacc ctttagctga 1853221 tccaggacag ctgtttcttc ccagtaaaat cttgtatcta cagggacttg aagcttaata 1853281 ggttcccata tgccgctgtc ggaaacaaaa aacacgagac tgcggggcat gtcttttccc 1853341 attgcattca agtattgatt cattttagcc ctgattccat ccagacactt ttcctcctct 1853401 ggatcactag ctgccaaata ctcttttaat cggctgaatc ctgactttag ggcaatcttc 1853461 cattctcccc cctgctgctc tggatctctc atgtctgtat tgagatacag agagagaatt 1853521 ttatccggcg gttccaattg gacatactgt aatttgttaa tcaatgaatc aatcgccatt 1853581 ccgattcctc ctttttcaca ggttagtttt ctttttcctc tcttaaaaac gatcaaacct 1853641 gactttccgc taatttctag taataatgga attgttgttt acaatacgcc tctcttctaa 1853701 tacaattggt aactgtgttt ctaagctgtt ttttgaaagg agtttgatct tgtttactgt 1853761 taaagaaaaa aatcgtcaag agcttgagga agaactaaat gatttagaat ttcaaattta 1853821 tcgcatgcag gagaatatga aggatttatc taaagatgcc aaagtgcttg gtattgatca 1853881 atcgaaacat gatgagtgga tgattgtttc ctcgattgat gatggccaaa catgcaaaat 1853941 tatgctaact gattgtaaaa cggcataccg aggaaaaggc tgtttttcac ttgtagcgtc 1854001 ttacaaggac gatgccattc atatagggga tataaaaggc cctccgaatc acgggtttgg 1854061 ctccatttgc atgaaatatt taaaagatat tgcaagagac cataatatac cgaaagtcac 1854121 cggagacatc gccaaacggg attggaatca tgtagaccgg ctgattcact tttatgaaaa 1854181 acatcacttc aaagtatgta tcgatcatga tacccaatcc ggcagcatta agtgggttga 1854241 tttgtaaaaa agtctggaag aaagagccaa gatatgctgt aatggtataa aaccattgat 1854301 ggagggttct atgtacgcct caaaactgaa aaagggagac gaaatccgga tcgtgtctcc 1854361 cgcgaccagc atgtctatat tatcaaatga agcaaaaatc caagcaaaaa cggcgttaga 1854421 acgcttaggt tatcgggtaa ccatcgctga acacgcaaat gaatgtaacg aatttgattc 1854481 atcctctatc gagtcaagag tccatgatct gcacgctgcc ttttttgatc caggcgtcaa 1854541 agcgatttta acgacactcg gagggtttaa ttcaaatcag ctgctgcgtt atcttgatta 1854601 cgagaaaatc aaacgacatc caaaaattct gtgcggttat tccgatataa ccgctctttg 1854661 caacgctatt tatcaaaaaa cgggtcttgt tacgtattca ggtccccact tctcaacatt 1854721 tgcaatgaaa aaaggactcg attatacaga ggagtatttt ctttcttgct gcgcttcaga 1854781 cgatccgttt gaaattcacc cctcaagtga gtggagcgat gatcgctggt ttttggatca 1854841 agaaaacagg cgtttttatc ctaataacgg ccctgttgta atccaagaag gttatgcgga 1854901 aggtacttta attggcggaa acttatgcac gcttaatttg ctgcagggaa cggagtattt 1854961 tcccgaaaca gaacatacta ttttattgat tgaagatgat tatatgtcag acatccatat 1855021 gtttgaccgc gatctgcaat cactcatcca cctccccgct ttttcacatg taaaggcgat 1855081 tttgatcggc agatttcaga aagcatcaaa cgtatcaata gatcttgtaa aagccatgat 1855141 cgaaacaaaa aaagaattat ccggcatccc gatcatcgca aatataaatg ccggacatac 1855201 ctcgccaatt gccacgttcc ctataggagg aacatgcagg attgaagcta tttcgggtac 1855261 atcacgaata tggattgata aacattaatc agcttgtaaa tttttttaca agctttttta 1855321 gcgcaatcgg ctatgcatgc cgcacgagac atgacaaatg tcatatagga ggcatgatgt 1855381 gtgctactac aaaagacttc tctcattagc gtatactgaa ccgagacaca caatgagagg 1855441 atacttacta tgactgaaca aaccattgca cataaacaaa aacagctgac aaagcaagtc 1855501 gctgcatttg ctcagcctga aacaaaaaac agcctgattc agcttttaaa cacgtttatc 1855561 ccattcttcg gcctatggtt tcttgcttat ctcagcctcg atgtctccta tcttcttacg 1855621 ttagcattaa cggtgattgc cgcaggtttt ctgacaagaa tttttatcat cttccatgac 1855681 tgctgccatc aatctttttt caaacaaaaa cgctataacc acattctcgg ttttctgaca 1855741 ggtgtcctga ctttattccc gtatcttcaa tggcagcaca gccattcgat tcatcatgca 1855801 actagcagca atctggataa acgcggaaca ggagacatct ggatgttaac agtaaacgaa 1855861 tataaagctg catccagacg aacaaagctt gcatacagac tttatagaaa cccgtttatc 1855921 atgtttattc tcggaccgat ttatgttttt ctgatcacga accgttttaa caaaaaaggc 1855981 gcaagacgca aggaacgtgt aaacacatac cttacgaatc tggcaattgt cgcgttggct 1856041 gccgcttgct gtctgatctt tggctggcaa tcgtttttac tggtgcaagg cccgatattt 1856101 ctgatttcag gttcaatcgg tgtttggctg ttttatgtgc agcatacctt tgaagattct 1856161 tattttgaag cggatgaaaa ctggagctac gttcaggctg ctgttgaagg cagctcattt 1856221 tataaactcc cgaaactgct tcaatggcta acaggcaata ttggttacca ccacgttcat 1856281 catttgagtc caaaggtgcc taactataag cttgaagttg ctcatgaaca tcacgaacca 1856341 ttaaaaaacg taccgacaat caccttaaaa acaagcctgc aatcacttgc gttccgtcta 1856401 tgggatgaag ataacaaaca gtttgtgtca tttcgggcta taaaacatat acctgtaagc 1856461 cttccgcctg attcaccaga aaaacagaag ctgcggaaga atgcctgatg ataaaggagg 1856521 tcttctaata tactagaagg cttccttttt attgttggag ggtgcattct ggctttcaca 1856581 atgataaagt tacaagtaag atgaaaagct gaaaatgagg taagatcatg attaaaaatc 1856641 attttacatt tcaaaaacta aacgggatta cgccctatat atggacgata tttttcatcc 1856701 tccccttcta ctttatatgg aaatcatcat ctacatttgt tattattgtc ggcatcattt 1856761 tgacgctttt atttttttcg gtatatcgat ttgcttttgt ctcaaaaggc tggaccattt 1856821 atttgtgggg atttttatta attggcattt caaccgcctc cattactctg ttcagttata 1856881 tttattttgc tttctttatt gcttatttta ttggaaacat taaggaacgc gtcccttttc 1856941 atattttata ttatgtccat ttaataagcg cggccgtcgc agccaatttc agtctcgtat 1857001 taaaaaagga attctttctg acacaaattc cttttgtcgt tattaccctc atcagcgcaa 1857061 ttttattgcc cttcagtata aaaagccgca aggagcgcga acgacttgaa gaaaagctcg 1857121 aggatgcaaa tgaacggatt gcagaactgg taaaattaga agaacgtcag cgaattgccc 1857181 gcgatctcca tgatacgctt gggcaaaagc tttctcttat tggtttaaaa agcgacttag 1857241 caagaaaatt gatatacaaa gatcccgaac aagcagctcg tgaactgaaa agtgttcagc 1857301 aaacagcgcg aacttcttta aatgaagtaa gaaaaatcgt ttcctctatg aagggcatcc 1857361 ggctcaagga tgaattgatc aacatcaaac aaattctcga agcagctgac attatgttta 1857421 tctatgaaga agagaaatgg cccgagaata tctcattgct gaatgaaaac attttgagca 1857481 tgtgcttaaa ggaagctgtc acaaatgtcg tcaaacacag ccaggctaaa acttgccgag 1857541 ttgacattca gcagctctgg aaggaagttg tgattacagt gtctgacgat ggaacattca 1857601 aaggagaaga aaattccttt tcaaaaggac atggcttact cgggatgaga gaacggcttg 1857661 agtttgcaaa cggaagcctt cacatcgata ccgaaaacgg gaccaagctt accatggcaa 1857721 ttcctaataa ttcaaaataa acataaagga tggcttatat gattagtata tttattgcag 1857781 aagatcagca aatgctgctg ggcgctttag gatcacttct aaacctcgaa gacgatatgg 1857841 aagtcgtagg caaaggtaca accggccaag atgctgttga ttttgtcaaa aaacgccagc 1857901 ctgatgtatg tattatggac attgaaatgc ccggaaaaac agggcttgaa gctgctgagg 1857961 agctaaaaga tacaggctgc aaaattatca tcttaaccac cttcgccaga cccggttact 1858021 ttcagagagc tattaaagct ggcgttaaag gctatttgtt aaaagacagt ccgagtgaag 1858081 agctggccaa cgccatccgt agcgtcatga acggaaaacg catctatgca cctgaactga 1858141 tggaggactt atacagcgaa gctaaccctc ttacagatag agaaaaagaa gtgctcgaac 1858201 ttgtggctga cggtaaaaac acaaaagaaa tcgctcagga actcagcatc aaaagcggga 1858261 cggtgcggaa ttatatctca atgattctag aaaagcttga agtgaaaaat cgaattgaag 1858321 ccattacccg gtcaaaagaa aaaggctggt ttaaataaaa aaggatcttg gcatctgcca 1858381 ggatcctttt tgttaacctg aaattcccgt ttgagaacct cgtcgcaacc agaattaaat 1858441 tgatccatat cctcgctcct acgcccgctg aacgattgtt tggttaacag cccaataaaa 1858501 gactggattg aatgatatcc ctgttaaaat ggtcggccat tgcacatcag cagaatttct 1858561 gatattgatt atattgtatt ttcagtatga caaagttgtg ccacttcgct cccgaagctg 1858621 ccatgcccaa ctgcaagagc ctaatatcac aataaaaaac cgtctgaaat caatccgatt 1858681 ccgtaaatgg tatctgctac atccaactgc ttattatctg ccaaaaacac cagctcgttt 1858741 cgctgatcaa agatagtaac aaccagctat aaatgtcatg atgccgaatg tctctgtaat 1858801 gtggaatcaa tcttttaacc cgagagcccc tgaatcgcac ataaagaaaa acgggaccac 1858861 tttcttttat cagcatatga tataaacagc tctaagcaga acaaaaaaag acacaagcca 1858921 aaagcttatg tcttttatca caatctatat tattagttta agactttaac acttacagtt 1858981 ttgacgcccc aattagaagc atcactttta cttggtacaa atacgtcgat tttatttcct 1859041 ttaatagcgc cgccagtgtc tgctgctgtt gcttccccgt agccttcaac atagacttta 1859101 gaacctagcg gaattacatt aggatcaacc gcaataactt tcgcgttcgg gttcttattt 1859161 aagtcaatgc ctgtagctgt aacgccggaa atgccgccgt cgttagcagt gtaagcagta 1859221 gcagtaactg ttagttcttt tgaagcttct tgattatttg tatttgattg aacagccttc 1859281 tcctctgtgt taacagaagt ttctgcctca gcctttgttt cttgtttagg ttgctgttgt 1859341 acagcttctt gtttaggttg ctctttttgc acagcctctt gttttggcgc agcttgaggt 1859401 gcgtttgttt gcgcattctc agtagctgtg tttgctgctg ttgcctgacc ttttactgaa 1859461 agagttgatc cagcatagat catgtcagag cttaagttat tccaaacttt caggttgttg 1859521 actgtcgtgc cgaatttttg agcaatctta gaaagcgtat ctcccgcttt aattgtatat 1859581 tgcccagtcg tggttgtttc ttctgaagaa atggtcagtt tttctcctgc aatgatttta 1859641 tcagaagtta acttgttcca ttcttttaag tcctttaggt tcactccatt tttctgagag 1859701 attccccaga gcgtatcacc cttttgcacc gtaatttctt ttgcagaagc gtgagctccg 1859761 aatgcagttg ttgaaagtgc agcaactgcc acaaaggaca taatcgtctt cttcataagt 1859821 aaatcctccc ttgttagctt tttattggcg gctaacaggt gatatcgtaa cacacgtaaa 1859881 tgtcaaatca ataacaaaaa gatatgattt agattacagt tcctttacat gaaggatttc 1859941 tctctgatgg aaagacttgc tgaacccttg atataatagg cttcgcaggt ctttttattt 1860001 tgaggcgaaa cagagaaaat aaaatgtgtt ttttatagaa aaaaagattg tttttctgtt 1860061 tttttagtct gtcatccttg cataagcctg tatttcttgt aaaaaaagcc ggccgtattt 1860121 tgctcttttt tgttctccga ctccttttat agacaaaagt tcatcatcat ttacgggctg 1860181 ttttcctgac atttctttta acgtttggtc agagaaaaca acaaatggcg gaacaccctg 1860241 ctcagccgca atttctttcc gaaccatgcg caatcgttca aatagctcgt cattttcagt 1860301 aatcgctgcc gcttttaacg cttcttttct cgctactgat aattctcctt tcagcacatt 1860361 ccttccttta ctgctgacaa aaagagtcgg aaacgttccg tctgacatcc tgatgaagtc 1860421 gtcagaaata agaaattcga taaaatcact gatttcgcca acggattggt gttttaatat 1860481 cccgtatgtt gaaaggtcgg aaaagccgtt ttcaagaact tttttatttt tggagccggc 1860541 aagcacctgg gcaaccatcg tcttgccaaa ccgttctttc atgcgaatga tacaagataa 1860601 gaccatttgc gcctcccgcg tcacgtcatg ggccgctctt gtatcggtac agtttccgca 1860661 ctgtccgcac gcatcaggct ccttttctcc gaaatacata aggataaaac gctgcagaca 1860721 atcttccgta tgacagtagt cgaccatttg tctcagcttt tttaaatcct gcttttgttt 1860781 ctcttcatgt tctgattgct caattaagaa gcgctgcacc ataatatcct gcggtgaaaa 1860841 caggagaaca cattcactgg caagaccgtc ccgtccagct cgtcctgcct cttgataata 1860901 gctttccata tctttcggga tttgtgcatg cagaacaaat ctgatatttg atttatcaat 1860961 acccattcca aaagcagagg ttgccaccat cacttgaagc tcatcattaa gaaatctttc 1861021 ctgctgctct tttctcacat catcagccaa acctccatga taccggcctg ccctgacctg 1861081 atttcgtttc aatctctcat atatccgatc agcttctttt ctggtcgctg tatagacaat 1861141 tcctgcttca tgcctgttgt tttgcacata ttcgtctata aaccgatctt tattttctcc 1861201 ttttactact ttaaaggtta aattctctcg ggaaaatccg gtatataccg tgttttcttt 1861261 ttgaatatgc agctgtttgc aaatatcatc atgaacctcg ggtgtggctg ttgctgttaa 1861321 cgccatgatg acaggcttgt cgtgtaattc acggaacaag atttcaatat tcctgtagct 1861381 tggcctgaaa tcatggcccc attgagaaat acaatgcgcc tcgtctattg cgaccaaagg 1861441 aacatctatg ccctgcaaaa tccggataaa ctctatggac gttagtcgct ctggtgtaat 1861501 gtaaaaaagc ttataagccc cttctttgag tccgttcagc ctctcatata tttcctgatt 1861561 ggattgtgtg ctgttaatgt aggcggcgtt aatccccgct tcttctaacg catcaacttg 1861621 atccttcatc aaggaaatca acggtgaaat gacgatcgtc gtcccttcaa acattaatgc 1861681 cggaatctga tagcaaatcg atttgccgcc tcccgtcggc ataatgcagg ccgtattttg 1861741 cctcgcttcc gtcaccaagc ggatcgcttc atcttggccg ctccgaaact tctcataacc 1861801 aaaataatga gccagaaggg attgggctct atgtaacata acgtgtaaac ctcgcttttc 1861861 cttgaatttc tcccatcata tcataaaaaa gcggccttca tttctttcac acaaaaatgg 1861921 aatattcact ataccaaacc tttttagata aaataaaaag ccatttccga aaaggaaatg 1861981 gctttcgcta cgtcttgccg tatgcaagta agaaagtttt aaaccaccac tcctcaaagt 1862041 gggtgtttgc agaaacgttc ctgtcgtcct ctgcaatgga ggcatgacat tccggcttcg 1862101 atataaaact ccctattaca gcttaaaggt taaaacttaa ttaacaatac gcacaaagta 1862161 gcttctttaa tatagtacac catcaggcgc ttttaatcaa gaggtcagaa caattgttta 1862221 gaaaaacttt ttccagtgaa taaaactgtt ttttctccaa aatacctgac aattcgacaa 1862281 acaaaaaata tattacaata aaaaaaatag cctttattgc taaaagcgaa tgattatttt 1862341 cttctatatt aatgtgtata tacaaaaaga ctcctatttg taacgatagg agtcttggct 1862401 ttattagaat tttgcagcaa gatcttttgc ttcttgtaaa cctttttcaa cgatttcttg 1862461 cgcttgatca ggtgctgcgt tatgtccttc gatgacaact gtgtgcaagt cttgaacacc 1862521 ccagaaacca agaactgttt tcatgaagtt taatgacatt tcaagtgcag ccattggtcc 1862581 ttctgagtag acaccgccgc gagcgttaag aagcgcaact tttttgccgc ccattaaacc 1862641 gactggtcct tcttgtgtgt atttgaatgt aacgcctgcg cgagacagat aatcaacata 1862701 agtatgaagc actgctggca ctgtgaagtt ccaaagcggg aatgcgaaaa caactttgtc 1862761 agcttttaca aactggttca gatatttgtc agcaattgct gcttgttttt tctcatcttc 1862821 tgtcatttcc attccttgac ctgctttaaa tgttccgtta atcatatctc tgccaaggta 1862881 aggaaggttt tccttatgaa gatctaattc aaccacttca tcattagggt tgttttcttt 1862941 ataagcagct aagaaagctt cgtaaagttt agttgaaacg ccttcttcag ctgtacggtc 1863001 gcttgatttt acaaataaaa ctgtagacat ttgtattcct cccggtaaac tttttatatt 1863061 tacttacaaa tagtatgtta ctttcttttt tacgtaaagt caatcacttt attttgaata 1863121 tgagattttt tttcaaaaaa aagcaagtac atctaatatc ggtgtacttg cttggcattt 1863181 ttacttcgaa tcttgttcac gatccaagat ttcatacgtc tgcgagcttt tttgatcaat 1863241 tgtttctttg ttggataagt cttttacctg ttcatgaaac tctctttcat aagaaggagc 1863301 atctgtctcc agatcatcct ccacatcagc ttgggcctca actgtcattc ttgcataagg 1863361 aacagcttca agtctttcgt aaggaatctc ttggccggtt ttttcacaca cgccataagt 1863421 tccgtctttc atcttttgta atgcacggtt gacctcctct aacagctccc ggtcaatctc 1863481 tttcactgtt tggtctgtca tccggtctgt gacgagcgtc ccgtggtctg ccatatggtt 1863541 gtcaacccca ttggaaagct cccccacttc ttccgtcatt gattctgttt cctttttctc 1863601 gccagacaat tctttttgca tatcgagcaa tttatgatag agatgctgtg tttgttcttt 1863661 tgtcagtgcc atgtatatcc tctcctttct atcctgtttc ccgttttgcc ttctgtcaaa 1863721 catggaaaca tcgatggaaa gatgagctac tgcctttttg aacggatcgt gaccgctggc 1863781 gtcgatggtg cttcgggttt tcgttggcac tttttgtcct tctcttctgg cggtatataa 1863841 taggttgcgc ctatatttaa tctgccgctc agttcatcaa tggtcagctc gccgaattca 1863901 agatgatagt caactttttc gacattcagc gtttcaatat gtatataggt ttcttcagac 1863961 tcttgtttgc tgctttgttt ttgtttctca atcactgaga gtctttcttc acattcacgc 1864021 agtttgtcaa gttctggttt caagcaatgc ctgatcagcg accggaacat ttttttcatg 1864081 acatcacgac cctttgcata ctcctctttc gtctacatat ataatgaggt atatcccata 1864141 gaaaggagag gttttcatgc ttccgactaa catcaatatt tctcatctca agactaactc 1864201 gataggcacc ggctcatccc ttacctttgg ttctgcggag ttaaggaaca ggtgctctgc 1864261 tatcaaaaga aataacggtt ttggggaaca aaatgcagat ggtattgtta tggtcattcc 1864321 gattgaatca attgatgacc gtgatgtgtc agatgcactc agtatgaaaa tcaatcatca 1864381 ataacaatgg ttttcgcttg accttcgtct ttttgaatag tgatgtatag gattccgtct 1864441 ttaaaaatgg cattcatctt tccatgaaga tgatcggaaa gcggaatttt cttttcaaaa 1864501 cttccgtatt tcccttcttt ttggcgaaag tcctgttcat taaaatagga aaagcgctgc 1864561 cccttcacca ctaaataatc tccgtacgat aatatgtgaa cgtcttgttt acggtagcct 1864621 ggaagataaa ttaaaaactg cacttccgca acggtatcta caatatccat gctcggaaat 1864681 gaagcatctc ctttccctcg ctgatcttgc tgcgcaaacg gaaacggaga ttggccattt 1864741 gtcataaaag gggttttttg gtcttcatca aatacctgtt tccaaaagtc accgccgtac 1864801 atctgctgtg cgaattccat ccactgcttc atcttttcga aatccatttg aagccccctg 1864861 tcttaacata ctttataacc gccagcatac aactatagaa aggaggtttg cctgtggttc 1864921 aaccaactcc gtatatcaat attaatattt tcatgctgaa aattaattcc tttgaaaatg 1864981 cttcagcggt taacgtagga caaaatttat tggcagaatg gcaaaattca gataaaaaaa 1865041 atcaaggcta cggacagaat tttggagatg cgagcggatt tatgggcacg agaagccatg 1865101 tggatgacag agaccaaatt gattctccgg cctcttttga aagtgaagcg gttaactcct 1865161 caatcaaaag gaagtgatga gatgttcttt tcaccctccg tcgtaaatgt cggcggattt 1865221 aaaatcaata cgatggatcg aggttcctct ttaacactcg gtccgtatca gcaggtcgat 1865281 tactttttat cagctaaaat aaatcaaggg tttggagaag aaaatggcga ctttactcct 1865341 cttgtcgtgc cgatttcaaa tgtattagat gcagatcttg ttgattcgaa ctcagcgaaa 1865401 aacagtgtgg tgtaataaga acagggcgca catgccctgt tcttgttttt atatataaaa 1865461 aaagcctaac cattttttga acggctggct catcaaatat tcagctgcac aaatgctttg 1865521 tcagcaccgc ctgaacctcg cttaaatcgg tgtctttcgc aaattctaat tcgaaagttt 1865581 tgcttcttgt catcaataaa agcccagtgt ccggatcaaa cattcccgct tcttggatgg 1865641 caaagctttc aattgtttta tatggaagaa atacacgaac cttcttttta gaaaacattt 1865701 tattgtcaaa gaaaatgatc cgcttatttg taaagcaaat ttggtccact cggagcttat 1865761 aaatcgattc aattctttcc ccttcaacga gcaaagcctc aagcttcttt gcgtccgttg 1865821 atctgctaac agaaaaaata cccaatgaag aacccctctt tctgcattta tctatttgtt 1865881 ttatcattca ctacataaaa ataagtcctt tatccctata taagaatacg acatagaaga 1865941 catttaaacc attacgaaca gattacattt ttcaaatttt tgatttgttt tttggctttt 1866001 aagctgttgt catcaagtaa tacgcacata tagagaaaaa agtttcaata ttcagcaatg 1866061 tttttataaa aaagtggttt ttaatgattt ttttaatttt gttttatatt tcctgtttta 1866121 accacaaaaa aaccgcagct gagctgcggt tttatgtatc gactgctttt aacaaaatct 1866181 gtttgatgct tcaaggaagc attacatctc ttcgaagtat tctttataat agccgccgac 1866241 tttattcgta ttgtcgacca caaagagaaa ctcctctgtt tcatttttta cttcatattc 1866301 ttttcccggc gttaaaacgc ggtttacgat atattttttt gcgtttgtct gcacacactt 1866361 tactttttta atggtttctt tttcaagcca atttttatga atcatgatga aatctccttt 1866421 tcttatctat aagcttattg tagctttttt cttttgtaaa ttgcaatatc ggttattcat 1866481 tgattttgcc ttgatttcta ttatagaatg tttgtatacg cttacgtttg aagcaactat 1866541 cacagcttat ttctgctatt caatccagga atcaatgtgc tatcaccaag aatctcagaa 1866601 cagaccataa aaaatgactg gaggtttgtt acggatgagt tctttaacga tgcaagtgac 1866661 gaaaaggctg gagacatttt tacagggaac aaagaagctt tatattgacg gaaagtttgt 1866721 tccgagtgcc tcaggggcaa cctttgacac tccaaacccg gcgaccggcg aaaccttgat 1866781 gacgctgtat gaagcccagg ctgcggatgt ggacaaagct gttaaagctg cccggaaagc 1866841 ctttgaccaa ggtgaatgga gaacaatgtc tccagcttcg agaagcagac tgatgtataa 1866901 gctggcagac ttaatggaag agcataaaac tgagcttgct cagcttgaaa cacttgataa 1866961 tgggaaaccg atcaatgaaa cgactaatgg agatattccg ctggctattg agcatatgcg 1867021 ctattacgcc ggctggtgta caaaaataac aggacagacg attccggttt ccggcgctta 1867081 ttttaattat acgcgtcatg agcctgtcgg tgtcgtcggc cagatcattc catggaattt 1867141 cccgctcctg atggcgatgt ggaaaatggg cgcggcactt gcaacaggct gtacaatcgt 1867201 cctcaaaccg gctgaacaaa caccgctttc agctctttat ttggcagaat taattgacca 1867261 agccggtttc cctgccggtg taatcaacat catcccagga ttcggtgaag atgcgggaga 1867321 agcgctgacg aaccacgaag cggttgataa aattgccttt accggttcca ctgaaatcgg 1867381 aaagaaaatc atgtccaccg cagcgaaaag cattaagcgt gtgacattgg agctgggcgg 1867441 aaaatcgcct aatattcttc tgccggatgc gaatttaaaa aaagccatcc cgggcgcttt 1867501 aaacggtgtg atgtttaacc agggccaagt ctgctgtgcg ggctcacgtg tcttcattca 1867561 taaagaccaa tatgatgaag ttgttgatga aatggcatcc tatgctgagt cactccgcca 1867621 aggagcggga cttcataaag atactcaaat cgggcctctc gtaagcaagg aacagcatga 1867681 gcgcgttctt tcctatattc aaaaaggaaa agatgaagga gcaaaagcag tgaccggcgg 1867741 aagctgtcct tttgaagcag gatattttgt cgcaccgact gtgtttgcga atgttgaaga 1867801 cgaaatgacc atcgcaaaag aagaaatttt cggacccgtg ctgactgcaa ttccgtacga 1867861 aacagtcgat gaagttattg aacgggcaaa ccattcagaa tatgggcttg cagccggact 1867921 atggacagag aacgtcaagc aggctcacta tatcgcggac cgacttcaag ccggaaccgt 1867981 ttgggtcaac tgctataatg tgtttgacgc ggcgtctcca tttggcggtt ataaacagtc 1868041 aggactcgga cgagaaatgg gatcatatgc cttggataat tacacagaag tcaaaagtgt 1868101 atgggtaaac cttgaagact aacatgtatg tttaaaaaac tgctgcctgc cagcagtttt 1868161 tttctttctg taatggcagt aaaagacgct gaatatatat gcttctgaag gagttgagcg 1868221 tgatgggcac acttcaggag aaagtgaggc gttttcaaaa gaaaaccatt accgagttaa 1868281 gagacaggca aaatgctgat ggttcatgga cattttgctt tgaaggacca atcatgacaa 1868341 attccttttt tattttgctc cttacctcac tagatgaagg cgaaaatgaa aaagaactga 1868401 tatcatccct tgcagccggc attcatgcaa aacagcagcc agacggcaca tttatcaact 1868461 atcccgatga aacgcgcgga aatctaacgg ctaccgtcca aggatatgtc gggatgctgg 1868521 cttcaggatg ttttcacaga actgagccgc acatgaagaa agctgaacaa tttatcatct 1868581 cacatggcgg tttgagacat gttcatttta tgacaaaatg gatgcttgcc gcgaacgggc 1868641 tttatccttg gcctgctttg tatttaccat tatcactcat ggcgctcccc ccaacattgc 1868701 cgattcattt ctatcagttc agctcatatg cccgtattca ttttgctcct atggctgtaa 1868761 cactcaatca gcgatttgtc cttattaacc gcaatatttc atctcttcac catctcgatc 1868821 cgcacatgac aaaaaatcct ttcacttggc ttcggtctga tgctttcgaa gaaagagatc 1868881 tcacgtctat tttgttacat tggaaacgcg tttttcatgc accatttgct tttcagcagc 1868941 tgggcctaca gacagctaaa acgtatatgc tggaccggat tgaaaaagat ggaacattat 1869001 acagctatgc gagcgcaacc atatatatgg tttacagcct tctgtcactt ggtgtgtcac 1869061 gctattctcc tattatcagg agggcgatta ccggcattaa atcactggtg actaaatgca 1869121 acgggattcc ttatctggaa aactctactt caactgtttg ggatacagct ttaataagct 1869181 atgcccttca aaaaaatggt gtgaccgaaa cggatggctc tgttacaaaa gcagccgact 1869241 ttttgctaga acgccagcat accaaaatag cagattggtc tgtcaaaaat ccaaattcag 1869301 ttcctggcgg ctgggggttt tcaaacatta atacaaataa ccctgactgt gacgacacta 1869361 cagccgtttt aaaggcgatt ccccgcaatc attctcctgc agcatgggag cggggggtat 1869421 cttggctttt atcgatgcaa aacaatgacg gcggattttc tgctttcgaa aaaaatgtga 1869481 accatccact gatccgcctt ctgccgcttg aatccgccga ggacgctgca gttgaccctt 1869541 caaccgccga cctcaccgga cgtgtactgc actttttagg cgagaaagtt ggcttcacag 1869601 aaaaacatca acatattcaa cgcgcagtga agtggctttt cgaacatcag gaacaaaatg 1869661 ggtcttggta cggcagatgg ggtgtttgct acatttacgg cacttgggct gctcttactg 1869721 gtatgcatgc atgcggggtt gaccgaaagc atcccggtat acaaaaggct ctgcgttggc 1869781 tcaaatccat acaaaatgat gacggaagct ggggagaatc ctgcaaaagc gccgaaatca 1869841 aaacatatgt accgcttcat agaggaacca ttgtacaaac ggcctgggct ttagacgctt 1869901 tgctcacata tgaaaattcc gaacatccgt ctgttgtgaa aggcatgcaa taccttaccg 1869961 acagcagttc gcatagcgcc gatagcctcg cgtatccagc agggatcgga ttgccgaagc 1870021 aattttatat tcgctatcac agttatccat atgtattctc tttgctggct gtcgggaagt 1870081 atttagattc tattgaaaag gagacagcaa atgaaacgtg aatcttatca agcggagatg 1870141 ttcaattggt gtgaagccct gaaagatcag attcaaaagc gaggtcagct tgaccagttt 1870201 gaagatcaaa tcgacaagat gattgaggct ctggaagatg accaaacaac agaagaagat 1870261 tggtataaac aggccgctgc cctttatcgg gatattacag aatcagatga tacaagtgaa 1870321 agacgcgctt atgtccctat agggaaacac gtgctgccaa agcttcctta caaatactcc 1870381 gccttagaac cttatatatc acgcgatatt atgatccttc atcatacaaa acatcatcaa 1870441 agctatgtcg atggcctgaa caaagcagaa tcagagctta aaaaagcgag agcgacaaag 1870501 aattatgact taatcactca ttgggaaaga gagcttgcgt tccatggagc aggccattat 1870561 ttgcatagta ttttttggtt ttctatgcat ccaaacggaa aacggcgtcc tacaggggca 1870621 ttgttccaaa tgatagacct ttcatttgga agctattccg cttttaaaga acattttacc 1870681 caggcctcta aaaaagtgga aggcgtcggc tgggccattc tggtctgggc acctcgatca 1870741 ggacggctgg agattttaac ggcagaaaaa caccagctct ttagccaatg ggatgtgatc 1870801 ccccttttac cgcttgacgt atgggagcat gcctactatt tgcaatacaa aaatgaccgg 1870861 gccagctatg tcgatcactg gtggaatgtc gtggattggc gcgaggctga aaaacgtttt 1870921 gagcaggcaa aagaagtcgt ttggaagctc tattaaaaaa agcccccttt cctcgggggc 1870981 ttcgtgtgtt aaaaaatacc tatcacatgc aaaaacacga tgatgatggc aacaggagat 1871041 agatatcgaa tgagcagcag ccaaaccgca aaccactttc gtttgagatt ggaaccgctt 1871101 ttcagctcgt caaacaaatc ctgtttcggt atttttagcg gaacaaaaat cgaaatcagt 1871161 aacgcaccta acggcattaa aatattgctc acaagatagt cagccgcatc aaaaatagac 1871221 agatgaaata tagtgacgtc acttaagaca ccgtatgata atgcagacgg cacaccgaca 1871281 ataaaaatag caataccgcc taaccaagcg aatcgttttc tcttattgat atcgcctttc 1871341 gacagtactg cgaccaaaat ttccagcatt gaaaaagcag atgtcaatgc agcaaataaa 1871401 aatagaagta aaaatgctaa taaaaagata attccgaacg gcatttgatt aaacacagtc 1871461 ggcagaacgt taaataacag aaccgggcct tggtctggct tgaggccgaa tgaaaataca 1871521 gctggaaaaa tcgcaattcc ggccattaca gcaacaagca tgttcataac agttacagat 1871581 acagcggact gtaccagatt ttcctgtttc tctaaataag cgctatacgt taccatgaca 1871641 gatacaccga cacttaataa gaaaaaggat tgtcccattg catataaaat ggtattggca 1871701 tcaattgcag ttaaatcagg catgaggaaa aatttgattc cttccatcgc gccatcaagt 1871761 gtaaccgaac gcaccattaa aatgatgaat aatagaaaaa gcgccggcat taatacttgg 1871821 cttgcttttt caattccgct gcttacccct tttgcaacaa ctaaaattgt taccaccata 1871881 aagagcagct ggcctcctac agccaaataa ggatttgaaa tggtacttgc aaatatcgta 1871941 tcaaaaccag atgtttgcga taaaccgcca gtgaagcctt ttataatata aattaaaatc 1872001 catccgccta cgacactgta gaaagataga agaataaagc acgtcaccat gcctaaataa 1872061 ccgatccaat gccacttcgt tcctggagca agtgttttat aggactgaac ggcatctttc 1872121 tgtgttcttc tgcctatgat gaattcacct aacaataaag gcagtccgat taaaaccgta 1872181 aataaaataa aaataagtaa aaatgcgcct cctccgctgg ttccggcaac atatgggaat 1872241 ttccatatcg caccaagccc gatagctgat cctgccgcgg ctaaaataaa gccgagcttc 1872301 gaagaccatt gatttgcttc cttcaccgta tcactcctat ttgatctaac cattataaag 1872361 gttcattgta agaatatctt cctatatagt caagaacatt ttaattagtt tacatcatat 1872421 atctatagac atctgccaaa aactaatatt gaattattca gaaaattatt tataataaga 1872481 gaatgttatg aaatttgtaa gaatttctgc tgaagttctt gataagtgtg ttaggagtgt 1872541 ttttatggac atcattagaa aaataagcca ttttgcagga caaacctttg gcatatgggt 1872601 cattgttttt gcagtgctgg gattttcttt cccatcttta tttacgtgga tcagttctta 1872661 tattacgatt tttctcggca ttatcatgtt tgggatgggc cttacactgc aagccgatga 1872721 tttcaaagag ctggtcagaa agccttggca agttattatt ggagtaatag ctcagtatac 1872781 gatcatgccg ctcgttgctt tcggcctcgc atttgggctt catcttccag ctgaaatcgc 1872841 agttggtgtt attcttgtcg gctgctgtcc cgggggaact gcatctaatg ttatgacatt 1872901 cttagcaaaa ggaaatactg ccctttctgt tgcggttacg acaatttcta ccttattggc 1872961 acctgttgta acaccgttgt tgattatgct gtttgccaaa gaatggcttc ctgtctcgcc 1873021 ggggtctttg tttatctcaa tcttacaggc ggttttattt ccgatcattg caggtctgat 1873081 tgtcaaaatg tttttcagaa aacaagtggc aaaagccgta catgcccttc cgcttgtttc 1873141 tgtcattggc atcgttgcga ttgtctcagc tgtcgtcagc ggcaatcggg aaaatctgct 1873201 tcaatcgggg ttgctcattt tttcagttgt tatcctgcat aacggtatcg gttatttact 1873261 ggggtttctt tgtgcaaagc ttttaaaaat ggattacccg tctcaaaaag cgattgcaat 1873321 cgaagtcggc atgcaaaact ccgggcttgg ggctgcactt gccacggctc atttctcacc 1873381 gctatctgcc gtaccaagcg caatattcag tgtgtggcat aacctttcag gttctatgct 1873441 tgcaacatat tggtcaaaaa aagtgaaaaa gaagcaagct ggatccaaaa gcagcaatct 1873501 atcactttaa atatgcatca aaaagggtac atcactttat cgtgatgtac ccttttttat 1873561 tatccttcta ataaaagctg ttcaggatct tccagtaaat ttttgattgt cacgaggaaa 1873621 ccaaccgctt ctttaccgtc tacaattcgg tgatcataag ataaagcgat atacatcatc 1873681 ggacggtttt cgaaacgctc ttcatcaatg gctacagggc gcagctgaat cttatgcatg 1873741 cccagtatac cgacttgcgg gctgtttaaa attggagttg acatcaatga accgaaagtc 1873801 cctccgtttg taatcgtgaa ggagcctccc tgaagctcgc taagggttaa tttattgttt 1873861 cttgcttttt tcgcaagctc gccgatctct ttttcgattc ctgcaaatgt caggcgatcc 1873921 gcatcccgta caaccggaac gacaagacct tcatcagcag caacagcgat tccgatatcg 1873981 tagaattttt taacgatcaa ctcatcgcct tgaatttctg cattcaacag cggatatttt 1874041 ttcaatgcag ccacgaccgc tttcgtgaag aaagacataa agccgagctt cacttcattt 1874101 tgctcaaaaa attgatcttt gcggcgtttt ctgagattca tgacagccgt catgtccact 1874161 tcattaaatg tagtcagcat cgctgatgtt tgctgtacct ctacaaggcg ttttgcaatc 1874221 gtttgtctgc ggcgtgacat tttttgcact tcaacaggtt tgtcaaagct ttgctgtgct 1874281 ttttgagcct gaggctgctg cttttgctga ggagccggtt ttgatgccgg tttttcgtac 1874341 gcttcgacat cctgcttgcg cactcttcca agcggatctc cagttggaac ttgagacagg 1874401 tcaattcctt tttctctcgc aagcttacgg gccgacggag aagcgatcgt tcttgatttt 1874461 gcttcagatt gtgcttcctc gctcacctct tgtgcagctg gttcagcctg tttctcttct 1874521 tttacgcttt ccttgctttc tgttttctct gtaggagcag gggcagaact ttcacccgcg 1874581 ccttctgaaa tcgtaccgat aatttctccg acctggacgg tatcacccga atctttcaat 1874641 acctcttgaa gtacacccga ttcttctgct gtcaattcaa cattcacttt atccgtttct 1874701 agttcaagca gatattcacc ctgttctaca tagtcaccag gctgctttaa ccattgggct 1874761 attgttcctt ctgagattga ttctgctaat tcaggtacct taatttccgc cattttttca 1874821 tttccccctt agtttttgcg agtcaagcta tcagatacaa tacgttcctg ttctttttta 1874881 tgaactgtcg gatctccctc tgcagggctg gatcgtcttc ttcgtccaat atattgaacg 1874941 cttactccct ctggtgcaat ctctgtcaaa tacgggctga tataacccca agcccccatg 1875001 ttctgcggct cttcctgcac ccaaacgatt tctttcaggt tcggaagttt tgcaaataat 1875061 tctttgactc cttttgccgg gaatggatac agctgttcga ttctcgcaat gtgaagccac 1875121 tctttaccgt cttctaactt attaaaatga tcgctaatgt ctatagacac tttaccgctg 1875181 gataatacaa gtctggttac tttttcatag tcatgagaaa gtcccgactg ttcataaaca 1875241 ggctggaagc ggctttcgct gagctcctgc acttccgaca ccgtatttgg gttgcgaaga 1875301 aggctcttcg gcgtcataat gacgagcggt ctgatttctt cacgaagcag cattttagcc 1875361 tgtcttctta aaatatggaa atactgtgcc gcgcttgtca ggttggcaac cgtccagttg 1875421 ttttccgctg caagctgcag gaatcgctca attcttccgc ttgagtgctc aggcccctgt 1875481 ccctcgtaac cgtgcgggag cagcatgact aatccggatt tttggcccca tttcgcgcgt 1875541 ccggcagaaa taaattggtc aaaatacact tgagcagcgt tggcaaaatc tccgtactgt 1875601 gcttcccaca aaacaagcgt ttccggtgaa tgcacgttat agccgtattc aaaaccgaga 1875661 accgatcctt cagacagcgg gctgttatga acagcaaatg atgtgctgca gtcagataag 1875721 tgatgaagcg gcacaaattc tttgcccgtc tcactgtcat gaagcacaag gtttctttgg 1875781 gcgaacgttc cgcgctcgga atcctgtcct gttaaacgaa tcggtgttcc gtctttcaaa 1875841 attgaagcaa acgcgagtga ttctgccaaa gaccattcca cttttctgtc atcatcgaac 1875901 gccttggcgc gtctttctaa aatgcgcttt agcttgccga aaacattaaa tgactccggc 1875961 cagttgatca attcgccatt cagcttgcgg agcacatcaa aatcaatcga agtgtccaca 1876021 tctgggaaac cgtttgatac aggctctgga agttcaattt cacaagcagt gtgttccttt 1876081 ttagacggaa ctttctgata tgcatcctca atgcgcttcg ttaccgattt ttcgatgttt 1876141 tgaacgactt cctcggtaac cacgccttct tttaccagct tttcagcgaa aatttgtttg 1876201 acggtcggat gctttctgac agcatcatac agcattggct gagtggttga cggttcatcc 1876261 atttcgttgt gtccatagcg tctgtacccg atcaaatcaa tcagaaaatc cttgttgaat 1876321 gtttttcggt attcgaccgc aaacttaaca gctgaaagac aagcttcagg atcgtccgca 1876381 ttcacgtgaa caatcggaat ttcataaccc ttggccaggt cgctggcata ttttgtcgat 1876441 ctggattcag cgctttctgt tgtgaatccg atcatgttat tggcgataat atgaatcgca 1876501 ccgcctactt gatacccttt taaagagctt aaattcaatg tttcagctac aattccttcc 1876561 ccagggaatg cagcgtctcc atggattaaa atggccagcg attttgtttc atcttgtacc 1876621 gggtatccgc tttgtgttcg cgtttcctgt gccgctcttg tgctgccttc aacaatcgga 1876681 ttgataaatt ccaagtggct cgggttgttc gctaacgtaa tgcgcgctga ttttgtttca 1876741 gcgtcttgaa gctcccgatt cgcccccaaa tggtatttga catcccccgt ccatccgtag 1876801 ctgattccaa tggatccctc agacggtaca agatctttgt tcggcgcatg ctggaattca 1876861 gagaagatga tttcatacgg tttgccgagc acatgtgcca agacattcag gcgtcccctg 1876921 tgcgccatcc cgatgttgac acttgtcgtg cctgatttga cagattgtgc aataatgtca 1876981 tcaagcactg gaacaagagc gtccagaccc tcaatggaaa agcgcttctg cccgacgaat 1877041 gtgcggtgca aaaactgctc aaagccctct acttctgtca atctttccag cacagctgac 1877101 agcttttcag ctgagttctt ctggaacagc tcgccagatt caatctttct tgtcagccac 1877161 tcgcgctctt tgaagtcatg cacatggtca aattcaaaag agatggttct tttatacgta 1877221 tttcgtaaat actgaatggc ttctaaaccg ttcgaaatgt ttttaggagc gtctttgcag 1877281 atgacagacg caggtattgc ttttatttcc tcttctgtta gcccgtaatc ggataatgga 1877341 aaaagttcgc tctttttctc atcctttctg agcggattga cggaagcgtt caaatggcca 1877401 taggttcgga tatcttctgc aagtctgact gcggatgcga tcttttgaat cagatcggct 1877461 gtaacacgtc ccttttcttt tgttcccgag gcctctttta tatcgcttgg cggagcaccg 1877521 agctcgtcga acatttcctt caaatccggg tcaatgctgt tcggatcctg ggtatactga 1877581 tcgtaaagct ccagcgcata gccgaggttc ggaccgtaaa aatcttccca attcattcgt 1877641 tgtttcatac tattttgaaa catttgaata ttacccccaa cttaaataat caagtgattg 1877701 attcactatc ttgaaataac tttcgaacgc tgtgtccaaa attatgtaat aaaaacgctt 1877761 ccaacgatat tttaccactg tttgcaattt gattctacct tgattgttca caaaatagta 1877821 aaaaaccttt ataaaaaaca aaaaatttaa tcattcgaaa aaacaaacgc caaaaagcat 1877881 aggattaagg gctatcctat gcttttatga agcagttttt tcagcagcgg atacaaaaca 1877941 tccggtagct gatcaacatc cgggacaaat atactgaatt ttccgtacat atcctggatc 1878001 gtcttcattt gcgattcttc tatttctgag ttggagagaa aaacatttat cacttctatt 1878061 cctctttttc gggcttcgat aaccgcctca cttgtatcaa cgatcccatt ttgttcgtag 1878121 ccaaatgcgg ccggctctcc atctgagaaa acaattaaga acttttgcgc ctcgctgcga 1878181 tgcagcattt ttttcgtcat ctgcctaatt gcgtacccgt cacggttatc ttcttctggc 1878241 tcaagctgca taatggccgg tccagaatct tgtcttaatg atgattggaa gggaataacc 1878301 gtattgaaat agtttggctg gcttttttcg gttgcatcat ttgtgtcctc ccaaaaaccg 1878361 acaatctgat gcggaaccgc taccgatttc aacgcttcgt gaaacagcac gattcctcgt 1878421 tttgtttcgt ccattttgtc gaacatgctg gcggaacaat cgaccagcaa tgtaaaaact 1878481 gcgtcgattt ctgaagatgg ttcttgcttt ttgtagaaca ggcgcggatt tcgctcagtg 1878541 aagtaacgaa gaagcttatt gttcagtctc ccggcatgaa ggtctgttct cggcaatgtt 1878601 tttttatgct ccagcgtttt ttgaatcatt tgtttcaaac gcttttgata cgattcaatc 1878661 gtttttgcct gctgtttata agaaagctct tcttcactgg ttgccggctg cggttcttta 1878721 taaattggaa atgcatattt attttctttg ccgtcagcca tacccgctcc gttcggctgg 1878781 tctttttggg actccagcgc ttccagcttg gaatagtctt tccgtttcgt ttgtctggct 1878841 gatccttgaa cagagccaag ggcctgatct ccatcgtcgc cttcccttga agcatctttt 1878901 cctaaatctg attttgcgcc gtgttcaata tcaaattgaa ggaagctttt agacggtgct 1878961 tctgtttccc ggtgccatgt cggcatttct tcttcatgga tatcctcatc accgtctgat 1879021 tgttttggaa gcgtgatgtc atcactcagc ttcggcgctt ttttctcttc ttcaaataac 1879081 ggctgttctg cagcttttgc gtaatcaagc tcaggcaaaa agaagtaggt gttcaacatg 1879141 tctttatcga gtacctcttc aagtccgtcc atgaggtcct caacaatttt cagaacctgc 1879201 cgtgtcgaat ctgcttcata cacacgcaag agctgctgct caataaacgg gcgcatcaga 1879261 tcgatatctt cacgcatgga tggaagggtc tcgagcggcg attccgctgt gagcttgaaa 1879321 tagatcgcgc aaaagagcgc atcggtaaaa atgcttcgtt ccaaatttaa ggtcagctgg 1879381 gttgagaaat gttttctgta catgtctttt cgcttcgcaa atacatgttt cgtacccggg 1879441 cgctcacgtt tgatgcattc ttcgatccta atgtcttcaa gcagcataaa gagctgcttg 1879501 gcaaaacttt taaacgtaag atggcgatgg atatcattca aaaagttcgc aaactcatgc 1879561 agcgagctat atcttgttcc gactgaacgc aggtagacgt cgcttttcag acccgcttcc 1879621 atgtcctcag ctgccctgtc tttccaaaag tggctcatat agattttctt ttcaaatgga 1879681 ttgtaatagg actgaacgcc atactccact tctaccgctt cactcttggt gagtgttttg 1879741 gccaaatcag tcagcatcat aaataaaaat gaatcaatcg tgctgtcgtt aaatttgata 1879801 aatttcatcg cagccccctc attcaaacag agtttctgca atatttcgga cagccgcttt 1879861 ttcccgatca tcatcaagct tttctacaat tccccgctca atggcacgac gcggcggaat 1879921 ataagcagct aaatcacatg tatcgattaa agctctgatg gatgccgctt cttcagacac 1879981 ctgtccgtta ttggcctgaa cgatcaagtc agaggaaagc gtgataaatc tgtcaatcaa 1880041 tttctcgtct ttcaaggctg actgagacat gagcacttgt ttcagcagct cgcctttaat 1880101 ataaggcaca tcaatgatga caaaacggtt tttcaacgct tcattcagag gaacagttcc 1880161 gacatagcct tcattgatgg ctgcaatgac tccgaaaccg cttttagccc gtatgacctc 1880221 gcctgtaaac ggatttgtca tcatttttct gtaatctaat acaccgttta gaataggcag 1880281 tgtttccggc ttcgccatat tgatttcatc tatataaaga aaatggcctt ccttcattgc 1880341 ctttgtaaca ggtcctgaaa caaactcgat tgttgcctgg ccagattgat tttcaatcgt 1880401 tttataaccg accaatgcct cagcgtccaa gtcgactgaa cagttgacgc tgtgcatcgg 1880461 tttatgaaaa tagctggaca atgtttctgc cagctttgtt tttcctgaac ctgtaggccc 1880521 tttcagcagg acatttttcc ccatggctaa tgcaataatg gcgtcaaata aaatggcttc 1880581 atcctccgcc tcatagcctg atgttcctat aagcgattga aactctgggg aaataggctg 1880641 ctctttatat gataaaagct tttgttgtat atcttccggc aatgttaagt gctgtagttg 1880701 agttgtcata gacagattcc ctttcctatt catattccat taacgagtat actaaaaaag 1880761 cccctgtatg ctcaatacaa aagggcctgg atgatattac tgcttctcgt tatttcccaa 1880821 aagggctccg cagacaatac gcgcaccgga attgccgctt gggtttgtca gataatcgtc 1880881 cgcttgttca tgaataataa atgcacttcc gtcctcgtcg agaatattta gtttacttcc 1880941 ttttttcagt gaagtgtcag gcgcattcat tatgacatct acctttccat cagcaccgac 1881001 ttcaaggttc ggcagatctc cggcatgatg ccccatcgga ttattaaagc cgtgttcttt 1881061 gttcagtgga ttaaagggac cgcccgctga ttcaaaatcc ggcctgacac aagaaccttt 1881121 ctcataaata tgaaaaccga gagaagcacc tggacgcagg ctgtttgcgg aaatatgaat 1881181 atcgaggcct tcatcatctg attctttgat ctctataaaa ccgactgctt tcccttcacg 1881241 attgaccagc tggacatgat gaccaaacgc tgacgtttca accacttttt tttccggcac 1881301 ccggttagga gggtctggag gttttttttg tccgcatccg gcaactccca gtgccgtcag 1881361 catcatcaac agcaagagac ggtgcatact gtctccccct tgttttttct aacagtgtgg 1881421 tcaatcattg tctggtataa acaaaaaagc ctataaaagg ctttttgtca tactcatttt 1881481 taaaaataac ttcttgcgcc caagtaccgc tgtttccaat acgaattgct gagattggaa 1881541 atgtcgacgc ccgatgagct tgcatgaata aaatcaccgc cgcctagata aatccccatg 1881601 tgagacgggc cggatttata tgtggtaaag aagacaaagt ctcctactga cggctggctg 1881661 actttctgca tgacattcca ataccctgcc gtactcaatc ttgatataga tgatacatta 1881721 ttaatgaggt aataaatgaa gccgctgcaa tcaaaaccgg caggcgtgtt tccgccccat 1881781 cggtaaggca ctccgacata ttttttcgct tccgttatca ttctgtcaat cttcgaacct 1881841 atttgaatgt ttgaccctga gttatctttt ggctttgttg gctttgtcgg atttgaagga 1881901 ttagattttg atgctcccga aatagtcaga acctgcccga tttgcaacac atccgatgat 1881961 aaattgtttt tatcacggat gctttggaca gtgactccga gccgatttgc aattttccac 1882021 agcgaatcgc ctgcttttac cttgtacgtc gttgtttttg agggattgga gtttgacggc 1882081 tttttggaac cgctgtttcc gttcttaggt gaactgcttc cttttatttt gagcacctgt 1882141 ttaggataaa gtgtatctga tgttaagcca tttaaggttt ttaattcggc tacagtcata 1882201 tttaagctgt ttgcgatttt ccacagtgag tcaccaagct tgaccgtata tgtacttttt 1882261 gaagaacctg aagaattgga accgctgttt ttctttgatc catttgatcc gcttgaactg 1882321 cttgtccctt tgatcttaag cttttgcccc ggacgaatca ggtcactgct caggctgttt 1882381 aagcttttaa gctcagaaac actcatttta tgatttttag caatcatcca tagggaatca 1882441 ccatatgcaa ctgtgtatgt tgatgttttg cttgaattag atggggatgt cgtgcttttt 1882501 ttgctgcttt caggaacctt aagactttgt ccgacataaa gcaccgttga tttcaatttg 1882561 ttttcggatt tcagagctga tattgtcgta tcatactggc gggaaagttt ccaaagagag 1882621 tcaccgcttt ttacttttat cgtttttgct tccgcgggtg ctgcggccat cgacgaccca 1882681 acaactgcag aaacagccaa gccggctaca atcttctttt tcattcattc aacctcctaa 1882741 actgtttttt tgcaaaaaca gctagtattt tgtttccaaa aatggcacac aactgtttta 1882801 tcgtcaattt ttcagcaagt taaacccttt tcaaacattt ggcgcagcat tttcagcatc 1882861 gttcgacctt taaaccttca aataaacatc taacatttta cataagcacg atatgttttt 1882921 cgaaagtcta aggaactatt taagcgaggg taaaaatgat ggttttctat tgatgaacga 1882981 agcagtttct cctcctttct tgtctatttt tctaatcaat tctctatcgg cgtgtcaaat 1883041 cccttcctct gcattcttat gaaatggcaa aaagcctgtt ctttcgataa gaacaggctt 1883101 ttacactatg catttgctga ttgagttttt tgttttacag cttcaagaat gctgtcggct 1883161 gcttttttag agccgcctgc cgctttcagt gattgtccaa tttcttttgc cttttcagca 1883221 tacgaacgat tattcattac ttcttgtatc gtctctttca gtaggctttc agacaattct 1883281 tcctttttaa ttacttttcc tgcgccgact ttttctacct gatctgcgac aacaaattgg 1883341 tcgcctccca tcggaatgac aacgagcggg gtttcaaaat acaaaccttc acttgtgctg 1883401 ttcattccgc cgtgggtcac aaataagctg gctcttttca agatctcaag ctgagggaca 1883461 tacgggcgta caatgaaatt ctccggaatg tcgtttaact cacttgtttt aatatgcttg 1883521 ccgatggaaa gcacaacttt accgtcaaag tccttacaca cttcaaggca ttgattaaaa 1883581 aactgctttt gattattaaa aatggttccc attgaaataa acagcacgtt ttcattgtca 1883641 atctgatcaa atgggaaatc attgtttccg gctctttctg taatggaagg accgacaaat 1883701 acatatcgct cgccaaattg ctcagccagt ggctgaaatc cccttgatgt aaagacgatt 1883761 gtcaagtcac catcagctaa aaaaacatca aatggcttct tgatctctgc ttgaaaatca 1883821 gcatttaacg tttctgcaag ctgctggtat gattcataat gaggcgaatc ttcaagtgat 1883881 cctttcatgt acgctcccat catttccttc gcaaattcct cattcatcgc aaaggttgta 1883941 cacaatgaaa atcttggcag cttcagcatg ttggcaatga ctttacccgc gagaagatgg 1884001 tgatcatata tgacataatc atacgattca tgtttgactt cctcataaat atgagtcgcg 1884061 atatccttac aggctttcaa aaaagcgcag agcatttctg tgaaatctct ttcttcatcg 1884121 ccggttgcgt ttttcccgaa gtaatctcct ctgaaatcat gatactcacg aaactctata 1884181 tcaagagctg tgattttttc tttatattcc ttcactgcgt agtacgtaat gttttctccc 1884241 cgggatttca gctccttcat cacaccgata gagggattaa tatgcccttc accggggaaa 1884301 ccgatcatta atacattagc catgcggcag cacccttcct ttgagaattt atgtaatatt 1884361 ttatacggta ctataaatgc ataaacaggt aaagtatttc acttaattaa tattcatcat 1884421 atataacttt tctaccagtt tatattccct gtcttcaaga caaaaagcat tcagcttgaa 1884481 gcgaatgctt taataaagat gcgaattcag tcattttgtc tcatgatagg attcttaatc 1884541 aggccctttt tattattttt acgttcttgg tgaaattaac ggatataata caccgtcttt 1884601 ggcaaacgac atcttccctg tttcctctga aaccacgagc accagtgcat ccgtatagcc 1884661 cgacatacca agagccgccc ggtgccgggt tcccaaatgg atatccactt ccttcgtcgt 1884721 cagcgggagc acattggctg ctgacacgag tttgttttcc ctcactaata aagcgccgtc 1884781 atgaagaggg tttccgggaa aaaagatgct ttcaattaat gaagagctga tctcggcgtg 1884841 tagggaggtg cctttttgaa taaaacgttc aaccgggtct gctctttcaa tcacaattaa 1884901 agctccatgc ttatgttccg ataaggcttt aatcgccttg gccagctcaa taaatgccgg 1884961 cgtaaattcc tcaatgtatg attgcaaata aaaggaggat gcaatcccct gcatgtcctg 1885021 aaaaacgtgc cccaaatcat ctaattcaca aaggagacac tggtcttttt cgtgaagcgt 1885081 tttcaagatt agagatgcat cacctaatat ttgctctaag tacacctgta ttttcccctt 1885141 gaacgcattt tctgatatct gctcatagcg catagccttc atctcctgtt taaatttcca 1885201 acttttcacg aatgcttatc ttattgatgc acattctatt ggtaaaggag ggatgtaaag 1885261 aatggaaatc gaaagaatca ttcagtatat ttgcaccttt ttaggcgtga tttcgctttc 1885321 ttttatttat gcccaaatgt ttagaaaaac gaaaccgaca aaaaaagaat aggcccggcg 1885381 ttcattgctt tttatacata aaatgttata atttctctcg ttatgaaaaa gaaacggaga 1885441 tcaatgtatg aaagaaactc aaaacgcccg ggaaaaaatc aaacagctct tgcacatttt 1885501 aataccgata ttcattaccc aagcggggct ttctctgatc acttttctag atactgtgat 1885561 gtcagggaaa gtcagccccg ctgatttagc tggtgtcgcc attggctcaa gcctttggac 1885621 ccctgtttac acaggacttg caggtatatt aatggcggtc accccgattg tcgctcagtt 1885681 attaggtgca gagaaaaaac agaagattcc ctttactgtt ttacaagctg tatacgtggc 1885741 cgcgcttctt agcatcgccg ttttagtgat tggatatgct gcagttgacc ttattcttgg 1885801 ccgattgaac cttgatattc acgtgcatca gattgctaaa cactttttag gctttttatc 1885861 actgggaatt ttccctttat ttgtttacac cgtgttgaga tcattcatcg actcattagg 1885921 aaaaacgaga gtcaccatga tgattacact cagttctctt ccaatcaatt ttgtattgaa 1885981 ttatgtattt atcttcggga agttcggaat gccggcactt ggaggtgtag gcgcgggact 1886041 ggcatccgcg ttaacttact ggtgtatatg catcatcagt tttttcatta ttcataaaaa 1886101 cgcaccgttt tctgaatacg ggatttttct taccatgtat aagttctctt ggaaagcatg 1886161 caaaaatttg ctcaaaatcg ggctgcctat tgggttcgcc gtgttttttg aaacgagcat 1886221 tttcgcagct gtcacgcttc tcatgagcca ttttcataca gtgaccatcg cgtcccacca 1886281 ggcagccatg aattttgcgt ctcttttata tatgctgccg cttagcgtgt ccatggctct 1886341 aacaattgtt gtcggatttg aagcgggtgc agcccgtttt aaggatgcac gctcatatag 1886401 cttaatcggc atcatgatgg cgatcggctt ttctttgttc actgccgcct gtatcctttt 1886461 attcagagag caaattgcgg gcatgtacac ttctgacccc gatgtgctcc ggctgacaca 1886521 gcacttttta atttatgcgc tattttttca gctttccgat gctgttgccg caccgatcca 1886581 gggagcactc agagggtaca aagatgtgaa ctatacgctt gcggccgctt ttgtctctta 1886641 ctgggtcatt ggccttccgg tcggttatat ggtcggtacg tttacaagcc tcggtgcatt 1886701 cggctattgg attggattaa tagcgggact cgccgccgga gcagttgggc tgtttttcag 1886761 gctggcaaaa ctgcaaaaac gttattcgca aaaacaacac atttaaaaga ggtgatcaat 1886821 catggcaaaa aacaaaaaat tattcgagta tctttcccag catgcggaaa ccatcagttc 1886881 aacatggtat gaaacaatcg aggagactga tcccaattcc atttatgcct caacagaccc 1886941 tgttgtcatt cacaatttaa agagccagaa tcttgccttt aactataaaa taaaccgtat 1887001 ttttatagat gatgaggacg tatacttgcc tatactgaaa gaatgggcct ttgaagtcac 1887061 acaggatcaa gagcatttaa aaactcctat ccactatatt attcgggagt ttgtcagagt 1887121 gagagattta tatgtttctt atgtgaaaga atttgtccat ctcaatcaga atactgtgaa 1887181 aagcgaagaa gccgaagacc tgtatcacgc ccttataaaa gcgtttgatc ttgtgattca 1887241 tatttttata gaagaaatgt acaaaaacac aagccttcag cttcaggccc aaaaagatat 1887301 gattactgaa ttgagcgctc cggtcatcgt gctgtttcac agcgtcggac tgctgccttt 1887361 aatcggagat attgatacag tccgcgccaa gctgattatg gaaaacacac tgcatcaatg 1887421 tgcgaaaaaa aaggtgacac aactgtatat tgatttgtca ggagtagctg tgattgatac 1887481 gatggttgcc catcagctgt tcagtctgat tgaggcgctt cgtttaatcg gtgtttcttc 1887541 aactttgtct ggaatccgtc cggaaatcgc gcaaacagcg gttcagctag gtttgtcttt 1887601 cgaaggtatt tccttgagat ccactctcgc ttcagctatt gcatcggact taaaattaaa 1887661 aaaggtataa ggcttaaggc cttatacctt tttgattaat cattccattg atacgtccaa 1887721 tatatttctt cttcaaacca tgttgccata acaggttcat tatttttcaa tttctcttca 1887781 agctctctga gcatgccttc tgtttgtgtg cggtgagctc ttaacgcatt cattttaata 1887841 tcagctactt ctttgatatc aagtacgaca tcagcttcgc cgagaacctc ttctctgttg 1887901 cgggtaatgg ccatgcagat tgtacgcgga cggtcttctt tctttttgcg gtataatgca 1887961 cggataaccg cttccccgca tgcatcatgg tcagggtgca caccgtgtcc gggataaaat 1888021 gtgacaatta aacttggttt tacatcatct atgatctctt ccatgatatc agctaaatac 1888081 tcatcgtctt caaattcgag cgttttgtca cggagtccaa gcatccgaag gtcattgata 1888141 tccatttctt tgcaagcgtt gatgagctct tgttttctta gcagcggcaa cgtttcccga 1888201 ttcgcgaaaa atggatcgcc catatttctg cccatttcac ctaaagtggc gcaggcatac 1888261 gtaacgggaa tgtctttttt tctgtttaag gcaatgaggc ctgccactcc atatgattca 1888321 tcatcagggt gaggcaggat tactagtaca tgttctttca ttattattca cccttttctt 1888381 taaactgtga acggtttttc gctgatttgc agagaaatag ccagtttacc gcccggcagg 1888441 tgtcccgcca ttaataaacg gttttcttca tctaccgtgt attcagtcaa gccttcagca 1888501 taaatccagc cttcttctgt tttcaagcca acgcggtaag gcccgttgcc tttgattttt 1888561 gcctgatgat aagtgacttt tgcattgcga atatacgcaa caaccgtcat gttcttttca 1888621 tttaagtgcg ctgaataaga acctgtggtg gtttctaaat ggatatatac agggcggtcc 1888681 gcatatcgtt ctaaagatgc ttgcacatct tcttttatga tcgctttcat gattgctccc 1888741 ctctttcttc ttttaaatac tctgcacgtt ctgtatgtaa tttgaccagc tgatatttca 1888801 cagccggttc gagctgtgaa ttcacaatgc gctgaatcgc ggcaaaatat ttttccagca 1888861 tcggttttcg gagtcttgga tgtgttcgtt tatccaagag ctcaagatca atcgcctctg 1888921 ctaccgcttc tgcgtcatca tgtgcgagag atcggttatt ccaaagtgaa gcataggctt 1888981 tcactatctc tttatcattg tccatcgtct tgctccttta tgtcttacat acatgaaatg 1889041 attatacata atatatgcat cagctgaaaa gccaaaggcc tcaatggctt tttgacgccc 1889101 gtttccactt cacttgtgaa aacgtaaaca agagcagcgc agcccatata cagctgaatg 1889161 taaaagcctt cgagcttgaa aatggctcat ggtaaacaaa cagcccgatc agcagggtaa 1889221 tggtcggcgc aatatattgt aagataccga cttgatacag tggcagccgt ttcgctcctt 1889281 ccgcaaacaa taagagcggc aaagccgtaa acacaccggc caaaaagaga agcagccacg 1889341 tccctccgct ttctgcaccc gctggctgaa catgtccgct gaacagcaaa taccccaatg 1889401 caatgggcat aatcatgaat gtttccagcg ttaaaccgat ggcgctcggc aggcttgttc 1889461 tttttttgct taacccgtac agcccaaagc tgaatgcgag cagaagcgca acataaggaa 1889521 tggagccgta ttggaacgcc gagatgatga caccggctgc cgcaatcgaa acggccacta 1889581 attgcaggcg attcagtttt tcctttaaaa ataaaatccc aaggagcact gatacaagcg 1889641 gattaatgta atagccaaga ctagcctcaa gcaaaaagcc atggttgaca gcccatatgt 1889701 atacaaacca gttgatcgaa atcaggatag aagcaagaaa taaagagagg atccctccgt 1889761 tctttttcag agagcgcaac tcctgccatc ctattttcca ttgccgcaag aaaaaaagta 1889821 cgatacacat aaaaacaaaa gaccatataa tacgatgagc caaaatatca agagccggca 1889881 gctgttcgag aagcttccaa tagagcggaa acaggcccca catgataaat gaaacggctg 1889941 tgtaaataac gccttttttt gtttctgcat gttgcattga tatccctgcc tttctttaga 1890001 gcatcttata ttatatcacg tgaaagatct ggtgggcata tactattttg tccgtgaaga 1890061 aaggatgtga agacaatgtt tgagtggaac aagtactttc ctttccacaa tcaattttct 1890121 aaagaagcat taaaaaaagc tgatccgaaa gaagttgaaa cgtatgtcaa tcgtgtgatg 1890181 gaaagtgtgt tcggcagtga ttatgcggct caatttcctt tccgcgatcc tctcccccaa 1890241 aaagaacatc ccgccaaacc tgatgcaaaa cctgatgtca aacctgatat tgatatattc 1890301 gaaacagcag accatgtgtt tgtaaaggtg ccaatcagcg aagaatggct ggaacaagtg 1890361 agaatcaaac acacatctca cgaattatgg ttggaaaacc tcccaagagc agatcatccg 1890421 aaaaaagtaa accttccttg tttagtcaaa cgcaaaggaa caaaagccgt ctataaggat 1890481 ggccttctgg aagtcatgtt tcaaaagcag caagactaca atatgtccga ggtagaaatc 1890541 atccgataaa aaacggcctg caatcgatgc aggccgtttt ttattaatag aagccgggat 1890601 atcccccgta tggcacgccg gcaccaaaac cgtacggtcc gcctccatat ccataagggc 1890661 caggaggata ggcataggga cgagaatagt taaacagcgc actcccgaga aaaccgccta 1890721 ataaaccgcc gactagagga gcgccaaaca aaaaaggact acgcgccgga tatccggctg 1890781 gacctgggat tccgcgtaaa tacgaatgat gagggtacat gattttttcc tcctttatgt 1890841 ctgcctatac gtaaagtatt cagcaaggaa gaaaaacgat tgggctacgg actgtctatg 1890901 attgttacat cacaagccct gccaataaca cacagccgag ccctgtaacc gaaagaactg 1890961 ttgtaagcag cgtccaggtt tgaaatgttt ctttcatgct caagccgaaa aattccttta 1891021 ccatccaaaa tcctgcatca tttacatgac acgcaatgac actgccggct cctgttgcaa 1891081 gcaccattaa cgcagggttt acactgccag cctccataag cggagctgcc attcccgctg 1891141 tggtaagcgc agccacggta gcagagccta gacacagacg cagaaccgcg gcgatggtcc 1891201 atgcaacgaa tagcggcgac atgtttgttt gacggaaaaa atcagcgaca taatcgccga 1891261 ctccgccgtc aatcagcacc tgtttaaacg ctcctccccc tcctatgatg agcagcatca 1891321 tcgcaatttg cgaaattgat tctgaaatag atctgccgat ttcctgcata gatattttac 1891381 gggcatatcc catcgtatag agtgcaagca acagcgaaat gagcattgcc gttcccggag 1891441 tgccgataaa ttctataatg tcttttcctt ttgaatgttc actcaataat aaagaaaaaa 1891501 ttgttgccat tgccataaag ataaccggga ataaagacgt gacagcactg atcgcaaagc 1891561 ccggtgtttc atccagctga aattctttcc ttggtcctaa ccccgatagg tttccatgct 1891621 tttgatacgc accaggaaac cgtttcatcg caaatttatt aaataaaggc ccggcaatca 1891681 cagttgtcgg aacagcgatg atgattccaa aaagcagcac ctggccaata tgggcaccat 1891741 atgcaactga gatagcagtt ggagcaggat gcgggggcaa aaatccgtga gtaacattta 1891801 aggcggcggc catcgggatt cccagataca gaaaaggcat ttttaattct ttagcaatcg 1891861 cgtaaacaat cggtatcaac agaacaagac cgacttcaaa aaatagggca atcccgatga 1891921 taaaagaggc aaccacaacc gccgcctgta ttcgtttcct cccgaatttg tcaatcagcg 1891981 taatggcgat ccggtagccg cccccagcat ctgagacaag cctcccaagc atcgcgccaa 1892041 gtccaaacac taaagctaaa tgccccagct gcccgccaat tccagtctca attgaaagaa 1892101 caattttatt gatatccatt ccaagtccga tggctactaa aaatgaaacg acaatcagtg 1892161 agacaaaggt atttaatttt actttaataa tgagaaataa cagaatcagc actccgacag 1892221 ctacaattaa aatcggcatg gtacccctcc aaaagtgttt tatatgattc tcgcgacaat 1892281 gttttggcgc ttttcatgcc tagatgaaca gaaagcgctt tcattaataa ctaaaaacgt 1892341 cttggttata tgattgttat cttttgatca actaatatgt tcatactaat ctcctaatca 1892401 atgactgtca atcgttttta tgagcttgtc tcgattacct accgcctaac ccaatgattt 1892461 attagttata tgttgattaa cttttggtta tatgttatgt tttttaaagt tgactgccaa 1892521 tcattatatc tctccattgt ctggaagcaa atgagacaat atgagaacag acggataaca 1892581 acttcataag aggaggagta cacatgccat tattgcgttt tgatgtaatt gagggccgtg 1892641 atgaaaaatc gctgcaattg ttattagata ctgctcacca agcgatggtt gaagcatttg 1892701 gtgttccgga aagagaccgt tatcaaattg tccatcagca tcccgcaaac gagcttataa 1892761 tccaggatgc gggattaggg tttcagagaa ccaaggatat ggtcatcatt agcatgacaa 1892821 gcaaagcaag aaccgaaagc caaaaggaaa aattgtatgc tctgcttgct gaaaggctag 1892881 aaaaaaaatg cgaaatttcc cctgacgacc tcatggtatc tattactgag aatggtgacg 1892941 cagactggag tttcggtctc ggtgaggcgc aatttttgaa tggaaaacta taagatttcg 1893001 tctccccaca aaaaaaagaa gagagagctc caaagaagct ctctcttttt tcataaatgc 1893061 ggaagtcatc agtatagaag catccagcaa tacgaaaaac ctggatctcc ttttatatcc 1893121 ggtttaaatg ccaattggaa gctgactggg ttttggctga aaatataaaa ttttgctgat 1893181 ttgcataata agatacatca taatccccat ttacaatagg ttggatgtta tagcttattg 1893241 atcatttcct attttatata tccccttcat atgcacatga catttttgcc aatccggaaa 1893301 tatcagtctg acaaatataa aaagtcatgt aaacgggtgt gaaccgtact tacatgactc 1893361 accatggaaa caaaggctct ttttcaggtg ccgctttcct tatttctctt cttcacacac 1893421 tgtgtcacca ggctcgcaaa attgatcggc ccatgcctgc atttcttgaa atacagcttg 1893481 aagcgctgtt cctttttcag tcagcgtgta gatgactttg accggcgttt cagggagaac 1893541 ctgccgttcg acaatctcgt tttgttcaag ctccttcaag cgctctgcca acattttttg 1893601 gctgatcatc ggtattgttt ccgttatctc tttaaaccgt ttcggcccat ccattagcac 1893661 atggatgatc agaccgttcc atcgttttcc cagcaatgag aatgcggatt ccattttagg 1893721 gcacatcgta tttcccataa gtcttcatcc cttcatctat tgattgacat gtattcaatg 1893781 atccattaca ataatctttc aagttacatt tagtaagctt ctaacttttc tattatcata 1893841 ccacgtttat ccgaaggagg aaacactatg acgaatactc tggatgtttt aaaagcacgt 1893901 gcatctgtaa aggaatatga tacaaatgcc ccgatctcta aggaggagct gactgagcta 1893961 ttagaccttg ccactaaagc gccttctgct tggaaccttc agcattggca ttttacagta 1894021 ttccacagcg atgaatcaaa agcggagctt cttcctgtag cgtataatca aaaacaaatc 1894081 gttgagtctt ctgctgttgt tgccatttta ggcgatttaa aggcaaatga aaacggtgaa 1894141 gaagtttatg ctgaattagc aagccaaggc tatattacgg atgaaatcaa acaaacattg 1894201 ctcggccaaa tcaacggtgc ttaccaaagc gagcaattcg cacgtgattc cgctttctta 1894261 aatgcttctt tagctgctat gcagcttatg attgccgcaa aagcaaaagg ttatgacact 1894321 tgcgcaatcg gcggatttaa caaagagcag ttccaaaagc aatttgatat cagtgagcgc 1894381 tatgttccgg ttatgcttat ttcaatcggc aaagcagtga agcctgcgca tcaaagcaac 1894441 cgtctgccgc tttcaaaagt atcaacttgg ctgtaaggat atgaaaaacc ttagtccgaa 1894501 atccggacta aggttttttt atacaatcgc ctctttgtac cattcacgag cctgttcagc 1894561 ttcatgctga gtcagctgat ggcccccgtc ctgccagtaa acggaggctg atgccccgct 1894621 gtcacgcaaa tagcggtaaa gctcttctga ttcttccttc gtgcaaagag gatcgtattt 1894681 cccggcaccg ataaaaacag ggagccccgc catatcaggc agctcgatac cccgaatcgg 1894741 aaccattgga tgatgcagaa tagccccttt taacacatct ttataatgaa aaagcaggct 1894801 tgccgcaatg tttgcgccgt ttgaataacc gactgcaatc actcggccgc gattaaactg 1894861 atgcgtttct gcagcctcgt cgataaaatc tttcaattct cttgtccgca ccacaagatc 1894921 cttttcatca aaaactcctt cactcagacg tttgaaaaat cgcggcattc cattttcaag 1894981 caccgatcct ctgacaccaa gcaaatgggc atcagggtct ataaaccgcc ccaatgaaag 1895041 cagatcgtgt tcattaccac ccgtgccatg caacagcaaa agtacgttgt cagatgttcc 1895101 tttctcataa atatgcttca ttataaattc ccccttttaa agttcaggta aaatgtctgt 1895161 aatttgttgt ctatgtttct ccagccattc aggcagtttt aaggaagtcc ctagctcagc 1895221 aaacgtttca tctgtcataa agcccggttc atctgtggca atttcaaata agataccgcc 1895281 tttctcccta aaataaactg atgtaaagta ttccctgtcg agaatttctg acgaaggcag 1895341 atggttttca gcaataatcg gcagccattt cgcctgttcc tttttcttag tccgaaacgc 1895401 tacatggtgt accgtaccat atcctccgac tcctcttttt tcaggatgta aatggacatc 1895461 aatgacaccg ccgaccgccg ctgaagatgc cagtctgaca atctggtctt cttcggccac 1895521 tttggtgtat ccaaagcttt ccgttaacaa ttgtatggtc gcctgcgggt cgtaggaata 1895581 tagcagcaca cctttcattc ccgtaattgc ttcatttgtt gtgatcccgt caggcgtcca 1895641 ctcgcttttg ccgcttttcg catcctccat gatcgccagc ggaaggtctt ctgtatcatc 1895701 aaaaataaga cctttttcac caaacaacgt tttttcctct aggctcagcc cgcttttctc 1895761 aagacgttcc ttccaaaaag acagggagcc tgagggaact gaaaagtaca cccggcccgc 1895821 ttggcctttt cctaccgttc cctgtccgct tccttggaac ggaaaaaagg tcattattgt 1895881 accgggatct ccgttttgat tcccaaagta aaaatgatac gttccgggat catcaaagtt 1895941 tactgttttt ttaacgagcc tgagcccaag cacttctgta taaaatcgca agttttcttg 1896001 cggatctctg gcgaatgctg tgacatggtg caatccttct gttttcattt tctcactcct 1896061 atttatctcg atttcaagat atttattatt ttaaaccttt attgaaaagg atgcaaacca 1896121 tgtgttttga ttaaataatt gaaaaaatca tttttttcta ataattatct tgtgatcttt 1896181 tcttacaact gctattatag tgagcattat catgtttcag gaggaaagta aatggttaaa 1896241 aaagcactta ttgttattct cattcttttg ccattcgttc agctcgcgct tttgccgctt 1896301 gtgaatcgaa tagaaccgat tatgttcggc ctgccgtttt tccacttttg gctgctgctg 1896361 tggattattg ttacgccgtt atgctcgttt ggcatttatc agatgcaaaa aaaagatgga 1896421 ggacttgaat aatgcaaggg aatctgactg cacttctcat tactgctatt attgttttaa 1896481 ccgttgtctg tatcggcttt ctcgccggaa gagacaaatc ctcacgtact tctgtggaag 1896541 aatggtctgt cggcggcaga cgcttcggcg gtcttctcgt ctggttttta gtaggcgctg 1896601 acctttatac ggcctatact ttcttagggt tgaccagtac tgcttttaca ggcggaagtg 1896661 ttgcattttt cgccattcct tattctgtgt tggcctactt tatcgcctac ttcttcttgc 1896721 caaaactttg gaaagttgcg aaaattcata aattaacaac actcgcggat tatgcccggg 1896781 aacgttttaa cagtaagctt ttggcaagcc tcgttgccat cgttggggta ctcatgctta 1896841 ttccgtacat atgccttcag ctgagcggca ttcaagacac gcttcaggtt gccggcactg 1896901 gctatattaa cgtaaaattc gttgtgatca tttcatttat tcttgttgct ctttacacat 1896961 tcttcagcgg gattaaaggg cccacatata cagccatcat taaggacatt ttagtatggg 1897021 tcattatgct gtttatggtg gtgtccctcc ctctcattca ttttaacggc tggacgccaa 1897081 tgattgacac gttagtgaag gaagcgccgc aaatgctgac gataccgtca gaagggccaa 1897141 aaggcattcc ttggtttatc acagcatcta ttgtttccgc tctggcactt tttatgtggg 1897201 cacatgccgc tacaggtgtt ttcacggcga aaagcgctga tgcagtaaga aaaaacagca 1897261 tgtttttgcc gctttataat atcgtgttaa ttttggttat ttttcttggc tttatcgcct 1897321 ttcttgttct gccggaagat acaaatccaa ggctggcgct gctgcatttg attcaaacat 1897381 cttacggcgg cgtggcacaa ggctttgcat atgccactat cgctcttgct tcattaatac 1897441 cttgttccat tatggcaatc ggcgcatcga atttattcgc caacaaccta taccgggatt 1897501 tgattcatcc gaatgtgtcg caaagcaagc tgactcttgt cacacgttca atggtgtttg 1897561 ttgtcatcgg tcttgcgctg ctgtttggaa tgctgttccc gactgcctta gtgacacttc 1897621 agctattagg tgtatccggt atggtgcaaa tcttccctgc gattgctgtc agcctgttct 1897681 ggaaaaacca aacgaaagaa gcaacggtta tcggattatt agccggccta gcggtaacgt 1897741 ttattgtgta tatcactcaa tccgcacatg gcatttatga aggattctgg ggattggccg 1897801 ccaacatgat cgctgtggtc atcctgaatc cgctgttcgt taaaaacgcg ggatccaatc 1897861 ctgtcattga aggtttattt ggcaaaaaac aagacgctaa tccaaatcaa aagggcgcat 1897921 aaaaaaacca tacgcggcag ccgcgtatgg ttttttttac atttcttttt tcagtgtttc 1897981 aattgccttt tccatttgcg tatcattatc agacagcttc ttttgaagtt ctatcattaa 1898041 tttcgttgtt gtatcgccag tcagtatgcc tgtttcattc agcttctctt ttttctggaa 1898101 ctgtttgacg acagatacaa aatcctggtc atacatactg ttaaccttta ccttgtaacc 1898161 aagtgctttg agcattttct gagccacttt gacgtttgtg cctgtatcac ctgatttgta 1898221 cgttttatct gcgtccaaat acggcagctt cgcgtaatca ggcagctctg ctttcacttg 1898281 aggcttgatg ccttttttgt gaatccattc gccatcagca gtcagccatt tggcaactgt 1898341 cagtttgacg gtagagccat catcatattc ttttgccgtt tgtactgtac ctttgccgaa 1898401 tgtcgtctcg ccgattaacg gtacgtttga cgattcatga agggcagcgg ccataatttc 1898461 ggctgcgctt gctgtaccgt catttactaa aacgacggtc ggcttggtca ctttccgttc 1898521 tttttcggcc ttcatgactt cttttgaacc gtttttgtat tcaacctgca tgatgttttt 1898581 ccctttatca atgaacaggt tgctcatcgt aatcgcctgt tccattaagc cgcccgggtt 1898641 gcctctcaag tctaaaatat agcctttggc gccttttttc tctaaactgt caatcgcatc 1898701 tgtcagctct ttagctgttg tttcagagaa agaagtgatt tgaatttctc cgatgttgtt 1898761 gtctttcatc tctgaataga cagtctctac aggaatggta tcgcgcttaa tggaaagatc 1898821 gatattcccc actcccgctc tgttcagttc aagcttcacc tttgtgccct ttttgcctcg 1898881 gattaaagcg acggcttcat ttacattcat gccttttacg ctttttccat ttaccttaat 1898941 gatttggtcc ctcggtttga taccggcttt ttcagcaggt gaacctttaa ttggggatac 1899001 aataaggatt tctccgtctt tctcctctac ttgggctccg attccttcaa aagatgctga 1899061 aatcgtctcg tcgaatgatt tcgcttgctc ttgatccata tatgtagaat acggatcatc 1899121 cagtgattga atcattcctt taattgctcc gtctactaat ttgtcatcat ctgttttttg 1899181 gtaataatca cttttgattt gctcatacgc tttatttaat ttgtcgaact tgctgtctcc 1899241 tgtgcttgct gatttttggc ccaggatact ggaattgccc gtaataaata aagtaagcgc 1899301 cgaagcgaca actgcagtga tcagcacaat aaaaaacagt tttaattgcc gtttcaatta 1899361 aacaccacct ttttcttctt acattattat catggacgaa ttcttattcg tcaactcgga 1899421 gcagaaatga aagagaaacg cccttctttt gcttttcata aacctatgtc tttatacgac 1899481 atatgataag gaaaaaggag gattcgatat tgagccgata tttagaaatg ctgtccttat 1899541 tcggtgtcgc aggggcgcac ccaggcgggc tggctttttc aaaagcggtc ttgcaaaagg 1899601 ctgcaccctc tccggatcag ccgattcttg atgccggatg cggaacaggg caaacggcgg 1899661 cttatttagg acatttgctg tatcctgtaa cagtcgttga taaagatcct attatgcttg 1899721 agaaagcgaa aaaaagattt gcgaatgaag ggcttgccat ccctgcatat caggcggagc 1899781 tggaacatct cccgttttct tctgagtcct tttcctgcgt cctgtcagaa tcggtcctca 1899841 gtttttcacg cctgacatcc tctcttcaag aaatttcaag agttttaaaa cccagcggga 1899901 tgctgattgg tatcgaagct gctttaaaaa aaccaatgcc ccctgcagaa aagaagcaaa 1899961 tgatggattt ttacggattt acttgcttac atgaagaaag cgaatggcat aaactcctaa 1900021 gatcctatgg ctttcaaaaa acagaagcga tgtcacttct tccggaagac atggaatttg 1900081 aaccaaccac agaaatggat ttatcgcaaa cgattgatcc catctattac gatacgcttc 1900141 aaacacatta tcagctcatg cagttatata gtgagtacat gggtcattgt atttttatcg 1900201 cgtacaagta aaacggcgta tcgccccctg ttttcgtcca accttttttt cctatctatc 1900261 atatgctgat agaaagtcag gataggaggg gaacaatatt ggagagatat tatcatcttt 1900321 gcaaaaacca tcaaggtaaa gtcgtcagaa ttacagagag aggcgggaga gttcacgtcg 1900381 gcagaattac ccgtgtaaca agagacagag tttttatagc tccggtcggc ggagggccaa 1900441 gaggtttcgg ttacggatat tggggcggtt attggggata tggagcggct tacgggattt 1900501 ccctcggttt aattgcagga gtggctctgg ctggtttatt cttctggtaa gcatagaaca 1900561 aatgctagat tcaccagaca caatgaagcc cgcttatcta gtgtaagcgg gcttttcatt 1900621 ttaaattttc ttcacttttt caaagtactc ttcaagcgtt aaatcattat cttggatgac 1900681 ctttgcggct tttttgccta catagcgcag atgccatggc tcatattcat atttcgtgat 1900741 atcttcttta tttttcggat agcgaataat aaagccatat ttataagcat tgtcctgcac 1900801 ccatttcccg tctgccgtgc ttccgaacgc ttcatttagc tcaaagccat tgctccggct 1900861 cgaaatgtcc atcgcaaggc ctgtttgatg ctcgctttca cccgggtaag cgaccgcttc 1900921 ctttgccttc ctttcccctt ttaggcttac ttcattgtca aaaatgactt tctgtctgtc 1900981 atacgaacgg taccctgaga cagctgccag ttcatagcct tcctttttgg cagcatcgaa 1901041 cattgttttt aatgcgtcgg ccgcttcttt tctgatgtaa cgtttttgaa tcttttcttc 1901101 aaaagaaaac tctacatcag gtatgacaag atcgctaggt tcatagtttc cgggcagtgc 1901161 atattgttta ttgacaagcg cgagtatatt ttctggattt tgaatggttt ccagaccatc 1901221 gactttttta atatcattga aatactggct ttccaatgaa aactcactgt tttgagtgtt 1901281 tgattttttg ctgtcagctg ttttttgttc tgtttgcttt gtttctgctg tggttttcgt 1901341 atccttttga gcatctccgt tcgacatgct gcagccggct ccgactattg ccgttacact 1901401 cagagcggca gccagtgaga accatttacc ggactttttc atattacatt accttccttt 1901461 tatcaatcgt ttccgcatgc ataaagaaga ggctgccggc acccagcacg cctcttgata 1901521 tattttattg tgatacggaa tgtaaagcca cttctatcat atcatgaaat gtcgtttgac 1901581 gctcttccgc tgtcgtttct tctcctgtta atacgtgatc actcacggtg agaattgaca 1901641 gggcttttct tccgtgcttc gctgctaatg tatacaatgc agttgtttcc atttcaacgc 1901701 caagcacacc gtattttgca agtttttcaa tttgcgaatc gtcattgtag aactggtcag 1901761 ctgtaaatac gcttcctaca gtcaccggca cacctttatc ctttgcggca tcataggcat 1901821 tttttaaaag ctcgaaatct gcgcaaggcg caaaatcaac gcttccgaaa gcaactctgt 1901881 tcatttgtga atcagttgag gaggtcatcg ccaaaatgac gtctcgcact ttgacatctt 1901941 tacgaatagc gccgcaggaa ccgactctta ttagattttg cacatcgtag ctttgaatta 1902001 attcattcac ataaattgaa atagacggaa ctcccattcc cgtgccttgt actgagattt 1902061 ttttaccttt atatgtaccc gtaaatccat acatgcctct gacttcattg tagcattcta 1902121 cattttcaag atacgtttct gcaataaatt ttgctctgag aggatctccc ggcaaaagca 1902181 cagtatccgc aatttgtcct ttttcagcac ctatatgtac actcatctca tatcctcctg 1902241 taaatctaaa ttatcatcca gcccgtccat tttacaacga atgtcatgat gaaacaaact 1902301 tcagcattga ttataaagga atatatcgaa aaaagaaatg ttcgaggatc tgttaggcac 1902361 ttcctcagaa aaacggataa tcggggtgtt aatttgaaaa cctaaccgca ggaaggaggg 1902421 gtgggacatg ggtaaaaaac atcgtaaccg gatcaccggc caaaaaaaga acaatcatat 1902481 acctgaaaaa gatatcattg cagctgaaga agcacacggg aaagaatatt ccgctgccaa 1902541 acgcaagcct taaaactgca gaaaactgcg ggtttccgca gttttctttt cattatgtcg 1902601 tttgtacaat cagacgattg attttcctcc agccggcggg aagcagttga taatatgttt 1902661 tcccttttct gccttcatca atcaggatca cgtcccctgt ggccatgaat cttgcatcat 1902721 aatcactcgg aacagtgtcg aatacattaa acaaagagaa tgctcttttc agcacgtctt 1902781 gatgatcgct cccgttcagt tcagttcgat agacggctct gtagcccttt ttttcgccaa 1902841 accggggtgt ctgaaatatt gtcacgtcat aggaacaaga cttcttttta aacacggata 1902901 acatcatcaa gatcccctcc cttttatttc tttaacatat tggcgttttt gctgtgtttt 1902961 cctctctcta tttttgtcga aaccgcttaa tcttttcgtc aaaacctttt actaggaaaa 1903021 acagaagcaa gccgaggcta aagcctccta acacgtctgt cacaaaatga acccccagat 1903081 acactctgct tatgccgact aaaacagcaa ttacaccggc tatgatatat accatttttt 1903141 tatgcttaga caaaaacggg agatgtttca ctaaaaagta agcaataaca ggatagacac 1903201 aagcagcatt catggaatgg ccgctcggaa aactgaagga tgattcatga accagcggtg 1903261 caaaatcagg cctcactctt tcgatccatt cttttaagac tttgtttaac agccgatctg 1903321 tgccgaatac taagagcatc aacaggccgt cccatgtttt tctgtagaaa aacatgcctg 1903381 ctccaatgat gacaattaga gggagcagaa aagaagaagc accaagatgc gtgatccccg 1903441 tcatgacttc attaagccat ggctgacgga tcaaaacagc tgccttgctt attgcttcat 1903501 ctgcagattg aacagcattt gtatgaatgg ccgcagctag aattaaaaag aaaagaaaca 1903561 aactaacggg cttgtacaat tttaaccacc tcaattttca cagaagtcat agaacatgaa 1903621 taataaaacc ggagctgacc gctccggttt taagcctcac tcatcttcat ccagctcttc 1903681 atctatcata catttttcta tcaaataatc aaaggtaata tcagcgattt caaacagctc 1903741 atcctcactc ggtatgtagc cccgtcttgc aagctctctg taaaaaaatt cagcgatttc 1903801 ttccgtatca atcacaagat ctatttcttt catctccgta ccgcctcctt ttttatgttt 1903861 tatgaaaaaa caggctgaat tatacccggt gttctaaaca attctttcag tcatatattg 1903921 aataaaaaac gagccatggg aggctgacgc tatgattgct aaaatgatgg aagcactgga 1903981 cggagaaaga tttgatatca taatggaaaa aacgctcaaa ggaatgacgc gtgtgatgat 1904041 ttggggctgt ctgccatatt ttttatatgt cttgatccgt atgttcacaa attaactgaa 1904101 atgctctttt aaactttcca aaacaaacat catcatgtct ttatattctt catcctgaaa 1904161 catttcgtac agaattttgt agtcattata aatatccaga agctcatcaa caattgacac 1904221 agcaaggatg tgaagggtat cttgatcttc atcaccgcct tcaaactgaa gaagagcaga 1904281 cgatgcgata tcttcgccga tctcatggcc agtttctccg acataatgga caaacaacag 1904341 ctgatgcaca aactggtcca tttcatattt tctaagcacc agcgtgagat cctcttcctc 1904401 cgtttcaagc cactctccat cctttaaacg ggtcagctca taaatgatat cttcccagcc 1904461 atcttctaaa tatctccaaa tttctgttct atggccgata atgcgaaaga gttcttttcc 1904521 ataatcttta acataaacaa cgtccccaat aaggaattca tactcaatat caagcttctc 1904581 catgtcgaca atgacaccct cataatcttt ataaagctga atagatgatt caaagtataa 1904641 aacttcgtta tgattgactt cataaagata gtgtttatca atttggtgta cttttgtgat 1904701 ggtgccgact gttccataca taatgacgac tacgatatcc cctacttgga atttcggttt 1904761 attttgcttc atggtgtctc cccctcgccg caacatttct catacgctat cgtatgccgg 1904821 gtgaagccaa ttcgcatggg catgaaaacc aaaggaaata tccaattatg gtatgggtat 1904881 ggacataaaa aaatccgcag tgatctgcgg atgaaacagc tattatctgc cgtgcacttc 1904941 agactcgtat tgatcccaag cttcatcaaa cgtcgccatc gtgtgaaggt aatcagcatt 1905001 cagctccaaa tatgaactga tttcatgata atcggttgat gtttttggaa agctgtgatc 1905061 ctcatacgcc tgattggcaa attcactgat gctgtccttc ggcttagggt gtctgtattt 1905121 caataaatag tgataaaagg atttcatggg tttcccctcc tgatgtctgt cttttgttgt 1905181 tctattatac agttcaagtg taaaattaca acaaaagaat actgaaacat gactcaggag 1905241 aagtcaaaat agttgcgttt caaaattctt tctgtctcca tgagctgctg atatgtcagg 1905301 ctttcaggca gtttttttgt ttgaattaaa agcagctgat cctcaatctc tttaaccgtg 1905361 ttttcctctt gataggtcat accgcaggaa gaacatacca tggcaggggt gtctgtcagt 1905421 tctatagccc tcgttccatc agggagctcc cagtacaccg tgttcctgcc gggcaccgct 1905481 tcgagctcgc cgcaccattc gcatgttttc atgaagaatc ccctccgcat tcagtctctt 1905541 tctgtttttt ctgctgcgcc aaaaatttct tttctttgag ctgatctctt ttctcacgcc 1905601 gatcttttaa tgtttcatgc tccggatttg cgatgtatgc ctctctcctt ttgattctgt 1905661 ctacattttc aggtgtaaac gaaacttctt tgtcagcaaa aatggcactc agcccgatcg 1905721 gctccttttt gtcagcggtt tcagggaaaa cggactcaaa ataggcgtct gcctgattgg 1905781 ggatataatt ctctggttcc ggatatgacg taatcacacc ttcaaaattt cttaagatca 1905841 ctttgtcagg actttgtgac aggacatagt ttggctgcag ggcgatttta cctcctccgc 1905901 ctggtgcgtc aacgacaaag gtaggaaccg catagcctga ggtatgacct ctcagccctt 1905961 caatgatctc caaacctttg gaaacaggag ctctgaaatg ccctattcct tctgacagat 1906021 cacattggta aatataataa ggacggactc tgatttttac caagtcatgc atgagctttt 1906081 tcataattgg aaccgaatca ttaatacctg ctaatacgac agcctgattt ccgaccggca 1906141 ctcccgcgtt caccagcttt tcacatgcct caacggattc ttctgtcatt tcgatgcttg 1906201 tgttaaaatg ggtgttcagc cagaccggat gatatttttt caatatctcg cacagatgat 1906261 cggtaatgcg ctgcggaaag acgacgggag ctcttgttcc gattctgatg acttccagat 1906321 gcggaatgct gcgcagctct tttaaaatat attctaaaat ttggtcgttg atgagcagcc 1906381 catcaccgcc tgaaattaaa caatcgcgga tttcgggtgt ttcccggata taagcaattg 1906441 cagcatcaag ctgttttttg gggacgccca ttccgatttg tccggaaaag cgccttcttg 1906501 tgcagtagcg gcagtacatg gaacattgat tcgtgacaag aaacagcaca cggtcgggat 1906561 agcggtgtgt cagaccgggt accggtgaat cttcatcctc atgaagcggg tcttccagat 1906621 cgtattttgt tttgtgcatt tcttcagaaa gcggcacaga ctgcatgcgt accgggcatc 1906681 tcggattgtc ggggtccatt aaagaagcat agtaaggtgt aatatttaag gggatcgttt 1906741 tggtagaaat tctgacgcct tcctcttcat cctcggtcag attaatgact ttctttaaat 1906801 catctaacgt tcttacagtg tgtgtcagct gccaaagcca atcgttccat ttctcttccg 1906861 gaacgtcctt ccataactcg atctccttcc aatgccgttt cggtttatac catttgtttt 1906921 tcaaacgaac tcctcctcgc gcatattttg acttacagtt gcttgcacca aatattcatg 1906981 ttttcaaggc cttcggctat aaagcaatta ttgatcagcc ttccgccata ctgataacct 1907041 gaatggtaca acacagcatt catcccaaaa gacgaagcac gggcgagaga aaacacatga 1907101 acgatatcct ctccagccat ttctttttct aacgcctcga ttaaaaagct tgttaacgaa 1907161 tggccgcgat attccggcag cacagcgcaa tcggttattt ctgcatgccc aagctctgga 1907221 ttgatttctg cgcttgctgc gctgatcagg cggtcatgat caagcatgat ataatacacc 1907281 gtatttgcat tcatcgtctt ttcaatataa gcggggtcaa ataccggggt tgggtacgtg 1907341 cggaatactt ttttatacag catcgatagc tggtacatgt cgtttgtttc tgcttttctc 1907401 atcgtaaaaa cgggtgtact gtcgttgcga agacggggcg ctgtgcgata tatggcttcg 1907461 atgatctcct gttcctctgt ataagaatct gtttgtctcc ggctttctga aaggtaacgt 1907521 accatgacac aagccgaatg gccgagataa tagcccttta gatagccctc cggcgcaaat 1907581 aattgtttgg caaggatcgg ctcatcatgc tgcttcgcat agacaatgat tttttctgca 1907641 ttctcttctt ttgccgctgc cacgatatcc ggcagggcct tctcaatggc tccgtcataa 1907701 cgaaccactc tgattcgttt attaaagccg tcatggtcca aaactgctgt gacaccgcta 1907761 ctctttattg acttgagcat ccgcatcctc cccatctgta tgaaggccgc accaatccat 1907821 gacaaaaagt gcaataattt tagcagattc tatcatggct tcaacctcaa tgtattcatt 1907881 ggcctgatga gccgtttttg tttcccccgg cccgaaaacg atcactggtg tatctcctgc 1907941 atggtacaaa agccctccat ccgttcccca cggggaagcc tcaataatcg gctctgtctg 1908001 tttcattttt tgataggctg attgcagcac agaaattaaa gggtgatcat caggtaaatc 1908061 attcggcagc cattgagcgc caaaccattc gacttgtacg ggatggcgtt taaaccattc 1908121 gtcatggtat tctaaatcct tcagccagtt ttccaattca agttttacag cttctggttt 1908181 ctcatgggga gcaattccgc atctcccttc tatgacgaca cggtctgcaa ctgaagatgg 1908241 ccaggcaccg cctgagatgg tgccgatatt caccggtacc ggtattggga tattgtcata 1908301 cagcggatct gaaattctcg cattgcggac tttctccagc tcttgtatcg ctgtgataac 1908361 gtgcatgctt ttttcaatcg cgcttacccc ttcatagcgt gtgcccccat gtgcggataa 1908421 tcccttcaca gtgatccgaa accacatcga accctgctgc ttaataaata gtttcatatt 1908481 cgtcggttca ggaatcagcg ccccgtcagc acgatagcct ctcatgatgg cggaaagtgt 1908541 accggcgccg ccgcactctt catctacaac actctgaaac aatacatctc ccttcagttt 1908601 gacatcgcag gcgtgcaggg cttctaaagc aaaaagaagg gctgtattgc ctcccttcat 1908661 atccgttgag ccgcggccgt atattttacc gttttcttcg acagcttgat acggttcata 1908721 cttccaatcc tttacgcttc cttcaggcac aacatcgata tggccgttca aaatcaggga 1908781 cctgcctccg ccggctcccg tttttttagc cacgatattc gggctctcat gaaaatcgga 1908841 tcggttagat ttaaagtagg gatgctgttt taattgcttt atgcttggct cccatacatc 1908901 aatgtccata tgaaattgcc gcagcttttc aagcacaaca gcttgggcgt taaactctga 1908961 ccccaatgtg cttttttccc caatcagcct tttgagaaga cgaatggctt tggccgaatg 1909021 ctgatcaagc cactcgatta cttttctttc aatgtcttgc atcctcattc cccctcttaa 1909081 gaaaaaggca tatctatttt gatttcagct tctgtcagcc tcgtcacctc atcgattgtc 1909141 gagccattca tcagctcttt taaaatgaag tgatggctat cgacctcaag aaccgctttt 1909201 tcggtaataa tcaaatctac acagcctgca gcagttaatg gcagcgtaca tctttctgtt 1909261 aatttaggcc ttcccttttg atctgtatga ctcatgacga caaccacttt tttcgctttt 1909321 tgggcaagct ccatcgcccc gcccatacca ggcacctttt ttcccggaac aagccaattt 1909381 gccaaatctc ctgattggct cacctgcagg gcgcctaaaa tcgtaatgtc aattttgcct 1909441 tttctgatca tcgcaaaaga catggttgta tcaaaataag aagccccttt tacagcgcgg 1909501 acaggatatc ccgcggcgtt gcataaatgc gcatcctctt ctcccttttc gggactttct 1909561 ccaatgccaa ggacaccgtt ttccgcttga aacatgacct gcatgtcagg cttcaaaaag 1909621 ttcggtacca aggaagggat accgataccg agattcacaa tcatgccctg cttaatttca 1909681 gtagcagcgc gttttgcaat ctgttctctt tctgctactc ccaagcccat ttccacttca 1909741 ctccctcgct tcgtacaacc ccctcaacaa aaacccccgg tgtgacaatc atttcttcag 1909801 aaatctcccc catcggaacg atacgctcag cttcggcaaa ggttctcctg gcggccattg 1909861 ccataagcgg gttcatattg cgcgcggttt tgtcatacgt tagattgccg aattcatctg 1909921 caatgtaagc attgatgaaa gcaaaatcag cagtcagcgc ctcttcaatc aagtatcgtt 1909981 ttcccgccac tgttacgatg tccttttttt cgcaaaccat ttgattatca atgcccacgt 1910041 cggttaaaat accgccaagc cccgctccgc cggcgcgaat ccgttccgca agcgttccct 1910101 gaggtgaaaa ttgaacctct aacgtcccct ctgtcatctg ttttccggct actggattgg 1910161 aaccgatatg cgaggcgatc agggttttga cccgttgatt aacaataagc gggccgattc 1910221 cgatatccgg gaaaccggcg tcattgcaaa tcacagtcaa atccgttaca ccgctgtcca 1910281 atatcgcttc aatcaatgaa ggaggcgacc cgactccccc aaaaccgcca aacatcagaa 1910341 ccgatccatc ccgaacatct gcaattgctg tgtcaatgct gattgctttt tgaaatggcg 1910401 ccatttaatg tcaatccttt tttaagtttt tttcgaccgc tgcaactgtt tctgaaaaaa 1910461 tagagataag ctcttccatt tcaccgtctg aaatagtaaa aggaggagca ataatgacag 1910521 catctccttc tccactgtct attccagctt tggaaggata aacaatcagc ccgcgttttt 1910581 tcgcctcgct gacaataagc tgggttatcg cctgctctgg cggaaacact ttcttcgttt 1910641 tttggtctgc cacaaattca atgcctaata gcagtccttt tccgcgcacc tcacctataa 1910701 tgccgctttg agatgccgcc tcatcaagct tcttcttcag cacagcgccc tttttttctg 1910761 attgtttgat caagccgtgc tttaacacat atcgcaaaac ttcaagagca gctttggctg 1910821 aatagggatg tgcactatat gtgtgaccgc tcataatcac acctgaccct tgttttatgg 1910881 tttcaataat agaatcagat acgacggcag cagcaatagg tgcatacccc gcaccgagtc 1910941 ccttccccag tacagcaata tcaggtacgg tatcccaatg ctctgtcgcg agcatccttc 1911001 ctgttctccc aagccccgtc atcacttcat ctgcaataaa aagcacatcg tgtgtgcggc 1911061 atacctcact taatctctca taatatcccg gaggcggagt aatcgctgct cctgcagcac 1911121 caataatagg ctcagccaca aagccggcga tgaattggct tccgattctt ttaatcatgg 1911181 tgtccagttc atcagctgca gtctgaacaa agtcttcttc cgtctcgtga ttcagccgat 1911241 aaatatgtgg agctgagata gctggatacc gctcaatgag atgggtgaac cggtatctcc 1911301 tttcataaaa accagacaat gaaagcgctc ccaaagttat tccgtggtaa ctgctccatc 1911361 gagacaaaaa gatggatttt tgtgtttgct ttttttcctg ccaatactga atggcgattt 1911421 tcatagctgt ttctatcgct tctgatccgc tgttgacaaa aaaagaccaa ttcacatctc 1911481 cgggcagctc ctgtgccaag agagcggcta attgctcggc gggctcactc gtaaactgtg 1911541 agcggtaagc aaaagacacc tgatcaagct gttctttcag cttctcagtc acatcacgaa 1911601 ctccgtggcc gatattacat gtcaccgcac ctgacgagcc gtcgagatat ttttttccgg 1911661 tctgatcata aacatatgaa cccttcgcat aactgacaac cggataggcc gagctaagct 1911721 ctggcttaat caaataactg ctcatgctcc cacctcaaaa ccccttttac catattgtat 1911781 gagtgtccaa atggcggcat gacgttcccc gcaaaaactt tttcacataa aaagagcctt 1911841 cctaataagg aaggctcttt tgaaatttca gcatctagca aataaaagcg gctccaacaa 1911901 taattaataa aatgaacaag acaacaatta acacaaatgt atttgtcccg cagccaaatc 1911961 cgtaaccgta cccagagtat ccatacatgc tgttttcatc ctttcttatc acgatatacg 1912021 acattttatg cgggccaagt cccaaatggt ttgtgcaaac gcctatttca tgtaaggaaa 1912081 taatgaaata cagtatgcac ccgctcatat tttttaaacg tcagcttttc gtaaaactga 1912141 gttgcaccgt cagtgcttgc agccactaag taggctgctt ccattcctag tgatttggcg 1912201 atggacagca tttctttcac taagatactg ccgtagccct tcctttgaaa ctgatctaaa 1912261 attgccactt cttcgatttt agccgttttc tcttgatgat cgataaacag ctcgccgcac 1912321 ccaatgggaa ctttctgtgc ctggtcgctg taacaaacaa caagaatgat tatatctgct 1912381 tcatagaaag gatattttct ttttaatttt tgttcagcga ttgcttctcc aatataaatg 1912441 gaatcgtaaa ttttcataat agaagatccg tcgctaagac tttttgccgt cccccatgcg 1912501 gttaaaggat gtcccatctg ccccttccag tcactaagct tcatgtcata tagtagctca 1912561 tcctcgacga caaaaccgct ttttacaagt gactgcttca aaccgagcgg aaaaacatgc 1912621 tgcggcgacg cttttaaatg gagataattc gcatcaagca gctttggtac ggagggtaaa 1912681 aagttaagta accgctccaa tggaaacgta tcatggagct gaacaaagtt atgagaaaaa 1912741 atttgcggaa gctgcggatc tctgtatacg ctgtaatgat caaacgatgc cgattcagac 1912801 gttaacaata tatattgatg ttccgttttt gaataatgtc ctgtcatgaa cgtctccttt 1912861 ttatgaccta tacctttact ctgttgcaat attcaatttc tttataatct catcgtacac 1912921 cggataaaac ggctttccaa ttggaaattg ctgaatattt cggaaagaag cggagattgg 1912981 cttctgatgt aaaaaaaact tccttgttac ttgttcacta atcgggtgaa agacgccgtt 1913041 tagaaacaaa aacggctcgc gttcgatgaa aaacagacgt cggccaggcg gatttttgat 1913101 caattcagat cgtttccacg taatcggcgg cccttccgga agcgtctcca tctcttcttt 1913161 tccaattgtc actatgtctt ttctttgaaa ttgataaaat tgaaacgcat actggtccac 1913221 aattcgcctt ttttttccgg cttcgatata aaatattgca ggatggtcag cttcctttac 1913281 taaaatataa ttcggaatgt ttaaaatttt gccaatccta tattggaata aatatgggtc 1913341 tggaacagcg acagtccgat ttagatacaa aaaaccccac ttttctccaa caggatgcct 1913401 tacaccctga tcaaaaaaat acacattttg atctgaacct tttacaaaag agccgtcaat 1913461 caaatcggcg ggcagaaacc gatatgcatt ttgaaatgaa tctggggttt tataggttgt 1913521 gtctaatact tcatttatcg gcagaaatgg ggtaaagttg ttgagtctcg cccaaaaaat 1913581 tgcgtcgcca tgattccaat gcttcatatc atcatcccag tagcctccaa atttatggtg 1913641 aatgagatta agtaacgaac ggcgatgcat aactgagcaa tgatcaactt gaaaagcggc 1913701 ctgatcaagc actgcattgg catttctgta gaaatgtgag atttcctctc ccctttcgtt 1913761 tacatgtaca actttttgtt ttgaatagac cgcctgcgct tcaggcttat gtgaaaactc 1913821 ttgcaccata cggctcagcc gctcaggatg ataaacagtg tcgtcagtaa gataggaaat 1913881 gtaatcgccg tctgcaaatg ggagcgcact gttaattaat gtggcataac gggctgtttt 1913941 taatcgatct gcaggatgca cgaaactgtt atgatattga atgcgccggt catggagata 1914001 cttgtgaatc accgcagttg tttctgcatt cgaatgatca tccatgataa aaagctccca 1914061 aagatcatgc gtttgctgta tcacgctttc gatcgctttt tgcaaataat cgggtttgtt 1914121 gtaacttgtt aaaataatag acactttctc tcccatctat accgcctccc gccgtcaaac 1914181 ataaaaacgg ctccgcagca agcagagcct ctgtcatcat ttaaaaagca ccccagctta 1914241 caacacttga gagtgaaaca tgagatctcg tgttatttaa cgggttttgg aaaataacca 1914301 aatcagtcag aacttctttt acgatgacat tttgaagtgt atctccgttg atcaaattga 1914361 cttttgaaac cggtacgccc agctcttttg caaaaacaag ctggcgtctg aggtcagatg 1914421 gatttccttc agaagacgat tgacgtatca gcagaatcag caaaagcaaa ataaaatgca 1914481 gatcatcttg gttttcttct cgatccactt gtttctctaa atccaaatca tccctctccc 1914541 ttatccttat ctctgtttca caatatgtgc gacttcgatt tatggtatag gctatgtcca 1914601 ctccattaaa aaatcagcat tttccttaaa tagatgaaaa atagatcagg tacggcgttc 1914661 gactcatacc aaataacagc cggaagaata tgaataacgt gagttcacta tcgaatagga 1914721 ggtgtgtgta atgagctctg aaaatgcaca gttaaaaaag gatttaatta aagccgtttt 1914781 aagcccttta tttccaactg caacagaagg aggagaaaat atggatagta atcttaaagc 1914841 cttgcttgat gctgccatcg atcaaaaagt agatgaaagt gaaacggtta cggcagaatc 1914901 tattttagac ccttctcttc cggcaagatg gatttttgcc agaattacgc caggcactac 1914961 aatcagcatt gtgactgatt caggtgacat gatcggaccg gttgttttcg ttgctttcga 1915021 tcaggttcac gggatcgtat ttgtaacaca ggaaagctcc gtcactccgg caggccaagc 1915081 tacaacatta attgatgtag acaaagtaga aagcgttacg ttcttttcat aacatccgat 1915141 gaaagtcttg tatatccagt cgggatacgg aggaatatac agttattttg atcgctgggc 1915201 tgaagaatgt tttcagaaca ctcatacaga gtatatgatt gcagataaac ctgaagcaga 1915261 atctttgatg aagatcgaag cgtttcagcc ggatttcaca cttatgatgg ttggagaccg 1915321 cgttcctcac gactggctga cctggttaaa gggtaaggat atccccgtgt atgtttggct 1915381 gaccgaagac ccattttata tggatatcag ccttcaggta attaagcttg ctgacgccat 1915441 attaacgata gaacaaaatg cagctctcta ctatcaagag ctcggctacc agaacgtcta 1915501 ttatgttccg ataccagtta accatcggct gtttaaaaaa atgggcaccg aacattccta 1915561 tcattcaaat ctgttaatca tcggctatcc ttaccctaat cgggttcagc ttatgaaaga 1915621 agcggtccat ctgccattca cggttcgggt aatcggcaag gaatggggaa aatatctgcc 1915681 taaaaaagtg ctcaaacagc cgcatattga tgtcgtcagc acatgggttc cacccgaaca 1915741 ggccgttcat tattataatg gggcagacat cgtaattaat gcgcatcgtc cctatcattt 1915801 tgctttcaac caaaatacta tgcgcatcaa aaatgccagt tttaataacc gaacgtttga 1915861 tatcgctgca tgcgaagcat ttcaattaac agatttaccc gcggcgcatc ctttttcatc 1915921 cattatttct tatcacggca tgaacgactt taaggaaaaa gccgctttct atatcaacca 1915981 ccctgaagaa cggcaaaaag ctgcagcagc caattataaa gagaccgtac ccgcatttac 1916041 gtttgatgag cttcctgcaa aactaaaagc gattcatctg gcgctttctt gaaaaatcgt 1916101 tcattgctat gaacgatttt tttattcata gaaaaaagca gctgcacaag ctgctttcta 1916161 ttctagccgt cagaacggtc tttcagcttc ctcggattta cctgtttatg aagatcaggc 1916221 atttcgccga gatgctgtgc aatttgttcc cacgatacaa ttttgaaatt ttgattgacg 1916281 gcttgtccgt tatcaatatt ttcgccgtcc tgcgccacaa aaatcccgta cggatatttt 1916341 gggccaagtc cgaaaccgag aacatcaata ccatccgtgt cactagtacc gtctatcttc 1916401 tcgccatctg taatctcaaa gttggctaca tagcgatttt tcccctgccg ttcatacatt 1916461 gcatagctgt tatttccttg acttgaagcc atgagatatc ctttgccatt tggtgcataa 1916521 tagattgtca gtccttcaat atcagctgtc aaatgatctc ctgtcgcacg gtcaacaacc 1916581 tgcccctttg accctccgcc gggctcagcg ttaaatttcc agatggcctc atcttcctct 1916641 gctatgtata ggtttccgta ctcatcatcc gcaacaaggc cttcggtctg agaattcaac 1916701 ttaaattcac gcaccttttt ccctgttaca taaccctttc caccatcaac aatttcatac 1916761 tgctcaaatt ccccttgttt gcctgtcact aatgcgtaaa atgctcctgt tttctggctg 1916821 tgatacaagc tgaatccata aacctcagaa atattggtgg aaataggatg gttcggatct 1916881 gtaatgcttt tcaattttcc tttatccccg tctattgcat atacttcaat tgtatttttt 1916941 ccttcggacc ggttggatgc ggcagcaata tcaatttttt cgccgttcaa tggaaaatca 1917001 tagcgcagat cgacattatt gagcttgcca aactcataag aatgaagctg ttttccgtct 1917061 aaatcataca caacgagccc tgacttctta tttgttgtaa tcaacttgct tttttccggg 1917121 tgtttttcat gaacccaaat ggccgggtca tctgctgcat catcgccaga tgcgaccgga 1917181 tctgtctccg tgtgtgcagt cactttgaaa tgatgttcct cattcacata atgagccgac 1917241 accgaggttg ctgtcaggct aagcaataaa cccgcggcag tgcttagcag cattgttttt 1917301 ggaaccttca tttggtaccc tcctctttta tcactaacac tactattgta aaatatatac 1917361 aggtgattac cgtgaggaaa atgaaccttt ttttataggg tttctgactc ataaacaact 1917421 tattccccaa agaggtggtg agatgacttt gccagattta cttttgcgga gcgaaataaa 1917481 aatatgttga atatttagta cattatttat ttagttttgt ttttccctag ttacgtccgt 1917541 ttttccattt tctattaaaa aagaacactt tgtgacatga tcattcccct aaattttgtt 1917601 ttattggttg ctttcattaa ttcgattaca aagttgaaca tatgatgcat ggtagagaaa 1917661 cgagagttgg aggataagcc atgcctaaac agcaaacagc agaactaaaa ccatttttcc 1917721 ataacaaaac agttttagtc actggcggaa cgggttcaat cgggagtcaa attgtcaaac 1917781 gccttttgat gcttacacct aaacaggtga ttgtattcag caaagacgac agtaaacagt 1917841 atgtcatgag ccaaaagtat gcggaggata agcggctatt atttgtactt ggagatgtac 1917901 gcgatcacag aagggtgaat caggtgatga aaggcgtcga tatcgtcttt cacgcggctg 1917961 cgctgaaaca ggttccgaca tgtgaggacc atccatttga agcgatccag accaatctca 1918021 tcggcggaca aaatgtggtg gaagctgccc tttcacaccg agtgcagcat gtcattaata 1918081 tcagtacaga taaagctgta tctcctgtga acacaatggg tgccaccaag ctgttatctg 1918141 aaaagctgtt tcatcaagca aaccgccacg tccaaaacaa aggaaccttg ttttgttcgg 1918201 tccgctttgg aaatgttctc ggttccagag gttcggtcat ccccatatta tttgaacaga 1918261 tgatggaggg tgaacctctg accatcacag acaaaaacat gaccagattt ttcatgtcaa 1918321 tagacgatgc agctacattg acattacaat cggctgctat tacaaaaggc ggagaaacct 1918381 ttattttcaa aatggaatca ctgaaacttg aagaactgat tcatgggttt gaagaatatg 1918441 catcgcagca cgggctcccg cggccggctg cagtagaagt gggcaagcgt ccaggtgaaa 1918501 agcttcacga agaattaaca tctccacatg aaattgaatc actgtatgaa tggggcaacc 1918561 tttatgcgat ccttccagag ccggaaaaac atcctgactt tcgcaaagtc aatctgcctg 1918621 ggtatcaatc agatcaagcc ccgctcatta cgaaagaaag aattgctcag attattgaag 1918681 aattgcatca agagaaaaag gcataaaaac aagcctgtct atccattagg caggcctgtt 1918741 tttaacagtt tatttattaa agagatgcag atagctttcg tatccttctt cttttagctt 1918801 atgcttcgga acaaaccgca gcgctgctga atttatgcag taacgaagtc cgtttggccc 1918861 cggtccgtca ttaaatacgt ggccaagatg agaatcagca gttcggcttc ttacttctgt 1918921 gcgaatcatg ccgtggctcg tgtccagttt ttcttccact tcttcttcaa tcggctttgt 1918981 aaagcttggc cagccgcatt gggaatcaaa tttatctttg gatgtaaaca atggcttgcc 1919041 tgacacaatg tctacataca acccttcttc cttatgatcc caatattcat tttgaaatgg 1919101 cggctccgtg ccgttatttt gcgttacttc atattgcatg cgatttaatg actttatttt 1919161 ttcttcttta ttgtacgcca tttatttagc cccccaatgc tcgctgataa atcccgctcg 1919221 tccggaacct gtccggtagc gctgataatg tgctggattc tttttataaa aatgctgatg 1919281 gtagccttcc gcttcataga aaggttcagc ttttaaaatg tccgttacaa tcggatcttt 1919341 aaagatgccg ctttccgcca gacgttgctt ggaagcttcc gcaagctcct tttgtttatc 1919401 attatgataa aaaatggctg cgcgatagga actgccgcga tcagcaaatt gccctccggc 1919461 atctgtcgga tcgatttgct gccaaaataa ttcaagcagt ttttcataag ggaatacatc 1919521 aggatgaaac gtgatttgaa cggcttcacg atgtcccgtc gtttcactgc acacctcttc 1919581 gtacgtaggg ttttcagtat ggccgcctgt atacccggac accacttttt caattcccgg 1919641 ctgttcgtca aaaggtttaa ccatacacca aaaacagcct cctgcaaatg tggcgatttc 1919701 ttttttttca gacatactgg tgcctccttt gttaatacgt ggtattatta tattatagca 1919761 tgtaaaaata gaatgaaaat gattctgctt ttcaataaaa tctataggtt ttaagcaata 1919821 tgcttatgta atggaggttc acaaatttga aagtaagaac acagatgatg tacgatatgg 1919881 aaactttact ccgtaaagtc tttaaacaaa tacgcaatga aatcaatgaa attttagata 1919941 aagagctgtc gcggaatgaa ttcaccattc ttcgaatcct tagtgaacaa gggcctaaaa 1920001 aagtcactga atttgcgcct attttagagg tatcggcaag ccacattacg gctgtgaccg 1920061 atgcgctggt agaaaaggaa tggattacga gaatcagatc gaaggaagac agacgcatca 1920121 tccgcattca tatcactgaa gcgggcgaaa aagtccttca gcactttaac gagaaaaaaa 1920181 cggaatattt ctttaaacgc tttgactgct acactgatgc tgaacttgcc acgttaatcg 1920241 agctcttcag caaacttgat aaaaaacggt gaaaaaaagc acataccgat atataggtat 1920301 gtgcttttcg cagtgcttca cttatttttc agtaaacagc ttcattgctt tccagcggcc 1920361 atatctataa tacaaaaatg ccgcgcagct gctaaataaa aaactcattc cgattccaag 1920421 cccgattcct ttttgtccaa gccaagctga aaatagagct gtgaaaggat acctcaacac 1920481 ccaaaacgag atcaaattta ataccagaac ctgcagcatc gctcccgcgg ccctgacgat 1920541 tccgttcagc acaaaattaa ccccaataaa agggtagaaa aacgcgatcc acttcaaata 1920601 ttgttcacca aatgcgaccg catcaggctc actgataaat aaccttatga ggtatttacc 1920661 aaatacccaa atcataaccg caatcaccag catgcaggaa ataacagcta tcacacctag 1920721 ccttgcaatt gttcccactc ttttttcgtt tccgattcca atattttgcc ctgccatact 1920781 attgacggcc gtaccggcag ccattgctgg aagcgtgatg atgctatcaa gccgctgcac 1920841 cgcgccaaag cctgatacca cgtgatcccc gtatgagtta acaacactca taatcgccat 1920901 cataccgcct gtaatcacca tcatctgcag acctgccgga atcccgagtt tcaaaatcag 1920961 cgcggactct tcccacttgg gcattctcgg aatcgagaat ggcacaagct tgtgtttgat 1921021 gacataaaac aacccataca aaaacgcaat gccctgtgac aaaatcgttg aataagccgc 1921081 tcccgctatt cccatgcgga acacagaaat aaagagcggc gcaagcactg tattcagtac 1921141 aacagcaaac gcaataaacc ggagaggtgt cttgctgtcg cccagcgcac gaagcacagt 1921201 actgataaag ttataaccaa acaaaaataa aatgccgata aattgaatct gtaaatacgt 1921261 ctcagcaagc ggtatcattg actccggcgt ttttagaaga cgcagcaaaa gctctgagag 1921321 aaaaaaaccg gccgcgccga atccgatgct taggcctgtt aataaaacaa caaaagcgtt 1921381 aatatacgac gccattcctt ttatatcatc ttttcctttt tgctgagata aaatggttaa 1921441 cgtcgcattg ttaaggccca aaataaaaga cagcacggtc aaaacaatcg tgcttgatac 1921501 cgcggctgcc ccaagggcct ttgcccccag taaattgccg atccacaagc tgtctataaa 1921561 ttgaaaggaa acctgcaatg cgtttccgag cataataggc attgaaaaca gtacaagctg 1921621 tttcagcacg ttcccctgtg taaaatcgta tgctttcatc ttttctcctt gtgttctcaa 1921681 attttcttcg gaccacacga aaaaagagac gttgtttcat gtctcttttt tcatgactta 1921741 tcggtttttt ttcggtctcg cataccgaat gtaaacacca tcacacttag gaacaaggca 1921801 caataggaaa cattcaaata catttgatcc atatcttcag cagccagatg atgataagca 1921861 agccagccga agtacaggga aaatgtaaag gataataaac tgaaatactg gtaaatccgt 1921921 ttcattttca gtcacctcta ttgtttagga tggtaatagg aaaactcaat ttcatctttt 1921981 tctaaattta tcttatccgc tttgacatac attccattcg ttaaaggcat ttctgacaaa 1922041 cgcacttcaa tgcttttatc tccggggtga acatggacaa atgacggcaa ttcataaaag 1922101 ctgtccatat aatttaacac aaagctaatt ggtatactca atttccctaa cgaaaatttc 1922161 gtgacattca gctctacatc accgtttttt ttcacggtcg gctcaaaagc gataaacgca 1922221 tcaatagacg tggaaaatgc cttgattttc cctgcgacat gaacatcatc atcaatctct 1922281 actttataat caagcttgtt tgatgctttg tcgtttaaat atgagttaac aaacgcagct 1922341 aatgattctt ttgtgcttgt cacttgaaat ccatactcgc tctcagatgc atctttcacc 1922401 tgagcctgtt cccccggaag caaaacaagt gccacaaacc cggcggcgag gataaaattg 1922461 attgcaagca atataaaaaa cagtcgcttc cacttattca tgctgtcacc ctactctttc 1922521 ggtaatcctt cttttttaat ggcttgatag acgcgctttg cgataagaga ataacccgta 1922581 ccattaggat gaaaatcatc ttcctcagaa attcggctgc tgtcactttt ttgattaaac 1922641 aaatcttcga tatggacgat ttttgcatgt ttatcttttt tcagctcttt ttcagcaata 1922701 tggttccaat ccgtgacgac accatttatt tcatttagtt ctgataatgt aaacgtaaac 1922761 ggattgtaca tgctgacata aatcagctca gcgtgatcat tcagctcgcg aatttcagaa 1922821 atgatttttt caaagcgctt ttcgtacggt ttttccgctt cctgaaacgg ttcaacggtt 1922881 aattgcagaa agttttggcg aaggattttc atcaaatcat taccgccaat tgtaaaaaag 1922941 acataatctg cgtcctttat gcctttttga acctttttat cttttagttt ttctaataaa 1923001 tcatccgaac ggttcccttt tacagcataa tttttcacgt cgaccgtttt gacttgttta 1923061 tctgaccgga tagaatccgc caccttgccg acatatccct ttccgtcggg atctccgact 1923121 ccttctgtca gcgaatctcc gacagccgct atgacaatgt gttcttttgt tttcgtttca 1923181 tgggcttttt gttttccctc agatgatgta cgtatgctcg tacacgcagt aagaagcaaa 1923241 atcaaactgg ccatgattga aaaaatgcgc agcttcaatc ttgttgctcc ttcccattct 1923301 actagtggaa agtgtatcat gttttagaag atttgcaaat gcctagtctc ttagcttact 1923361 tgagtgtact ggctgacttc acatcggaaa tgatatcatc gtacggtgta ttctccactc 1923421 cattgtaatc tttcagcacc ttaccgtccg gacctaccaa ataaaaagaa gattgatgaa 1923481 tcacttggtc ctctccctcc ggcttcttta cgatcgcttt aaagctctta agtgcgaact 1923541 cctcaatctc actctggctg tatcccgtga gaaaatccca gttatcaaaa gataatggat 1923601 aatttgcggc aaatttcttc agctgtttcg gcttatcgtt ttctggatca acactaaatg 1923661 atatgatgcg gacatctata ttttcggctt tcagtttttt ttgcagatcg gtcatatgag 1923721 cggtcattgg cggacatata gtttcacaat tggtaaaaat aaaatccgcc agccatactt 1923781 ctccttttaa actctctaaa gaaacgttct tgccgtcttg gttttgaaat gtaaaaggct 1923841 ccacctcgta attgagcgga tctttaatct gctgtcctcc gcatgcacac aaaaacagaa 1923901 aaatcagccc agccgttaac cccttgataa ccttcatgac atccatcctt tccagccagc 1923961 ataaaaacgc tttctaaaac cgtccttact gtcccatgtt tgtattcgat actgagcaaa 1924021 aaaaatcctg catgcctccc cattaacgat tacaaaggag ggcatgcagg taaaaaacgg 1924081 catgttacgc gttgtgcttt aacacctctt gatgaaatac agcctgataa tctgcccact 1924141 tcatccgccg cttcatataa tgtcggaaag aatacacttt tgccctgctg tttgatgaaa 1924201 acacttcttt taagtagaat tgcaaatggt gatgtaacat aaagaaatag tgctcatctt 1924261 cctttaatac aggtatttct gtcactttca cctgaatccc gtcaccgcgt ttgaactcta 1924321 ggcttttgag taacaagcta tcaatcctct tttttgtttt tcttctatta tatatgatgc 1924381 cagccgggct gtctgtcatt ttgcgcggtt gtgtaaaaaa attagattag caaatggaac 1924441 aagtcctcat ccttgttcac ctctacataa tgaaacggtt ttttgttcat ccgttcaatc 1924501 agcggcccat aatcggcttt gttctgcagc tcgatgccga caagagcagg tccattgctt 1924561 ttattatttt tcttcgtata ttcaaacctt gtaatgtcat cattcggccc gaggacttcg 1924621 tcaagaaatt cgcggagcgc ccccgctctt tgtggaaaat tgacgataaa ataatgctga 1924681 aggccttcaa aaatcaagga acgctccttc atttcctgca ttcttccgat atcgttattg 1924741 cccccgctta ccacacacac cacgtttttc cctttaattt gatccttgta caaatcaagc 1924801 gctgcgacag aaagagctcc agccggttca gcaacaaccg cacattcgtt atataattca 1924861 agaatggatg tacatacttt tccttcaggc acaaggagaa tgtcatcaac gacagtttcc 1924921 agcgtccgga aggtttcctc gccaattttt ttaacagccg ccccatctac aaacttatca 1924981 attttatcaa gtgtgacgac atgcccagct ttgtttgatt caaagtagga tgccgctccc 1925041 gccggctcaa cagcaattac ctttgtatca ggagacacgt ttttcaaata tgtacctacc 1925101 ccagagagaa ggccgccgcc tccgacactt gcaaaaagaa aatgcggttc tgtatcaatg 1925161 tcgtttaaaa tctcgactgc gagcgttccc tgtccggcca tcacatccgg atcatcgaac 1925221 ggatggataa acgtccgaga ttccgcctca cagcattcag cagcgctttt atacgcgtcg 1925281 tcaaacgtat cgcctgtcaa aataatatcg ataaatcctt ttccgaatag ttcaacttga 1925341 gatacttttt gtctcggtgt agtagacggc ataaaaattt tcccgtgaat gccaagatgt 1925401 ttacacgaaa atgccacacc ttgagcgtgg tttccggcac ttgcacacac aactccgttc 1925461 tctgtctgct cgctggaaag ctgtttcatt ttatgataag cccctctgag cttaaaagat 1925521 ctgacaactt gcaagtcttc gcgttttaaa tagatattgc attcatatct ctcagaaagt 1925581 ctgtcattcc tctgcaaagg tgtgtgaatg acaacgtcct ttacgttttg gtgagccttc 1925641 aaaatgtctt tcacttggat gagagagttt tctttaagca acggtttcat gtacagattc 1925701 ctttcttgtt ttaaatccct atttaatatg ccattataac atgaatattc aaaaaataag 1925761 acaattattt ttatttaata attaaaaaaa tacagactat gtccaccaca tcttgtggta 1925821 acttctgttc aaccattatc ctgcagagcc aagaaaaaag atgatcgtaa aataaagggt 1925881 gttttcaacc aaaaggcatg atataatgaa accaattaga accaaaagga gccaattgat 1925941 gaatagtgca ccaaaactca atacatttca acatctaatc ggagaacatc aaacttttct 1926001 ggaagcgaag cgaatcgcca agcagttctc gttatcggag cttcctgtct taataacagg 1926061 aaaaatcgga acaggcaaaa atcacttcgc acatgccata cacttggaat cttcgagaag 1926121 caatgaaccg tttataagcg tcaattgcag cacccattcg gaagaaaccc ttattcatga 1926181 gctttttggc cctaacggaa acacaggtgt ttttcaaaaa gcggtacgag gaaccctttt 1926241 tcttgatgat gtatggcgca tgcctgcttc tgtacaagct cagctgttaa aagcgcttga 1926301 ttcagacacg gagaaaccgc gaatgatctg tgcttctgca gaccgatccg tggaacatac 1926361 attcaggcaa gacttattct acagactgaa cattttaacg ctcacactgc ccgaattatc 1926421 ggaacgaaaa agcgatattc cgcttttgac acagcatttt ctctcaaatt ctggtcagca 1926481 attgttaatc gatccctccg tttttcccgt gcttgagaag catgcatttg aaggcaatgt 1926541 cagggaatta aaaaacgctg cagattatat ggcggcagta tcaagcgggg gaacgattca 1926601 gccatatgac ctgccgccgt atattagagg cacgatagac ggaaaaacgt cgaagaaaaa 1926661 agcgaaactg cttactttaa tggaaaaagc tgagtttttg tttattttgg aaacaataaa 1926721 agtattgaac gaaaaaggag aacctgccag cagacggatc atttctgaac acagcaaaaa 1926781 tacccaaacc tcgttaactc ctcagcaggt cagaagccgt ctcgactatt tggagaaaaa 1926841 agattatgtc accaaaagcc gcggacgcgc aggcacaaaa attacctttg agggcttgag 1926901 ctttatagag acgttaaaaa atcaaatgat ctagcgatcg aaaggagaat gtacttgttt 1926961 acaatcaaag aagagatcgc caatgcgatt acacacggca tcggtgtcct cttatccatc 1927021 ccagcattag tgtttctaat catatttgcg gctaattacg ggtctgcatg ggacattgtc 1927081 agctttacaa tattcggtgt ctctatgctg ctgttatatt tgagctccac cctgcttcac 1927141 agcatcacac ataaaaaaac gaaggacatt ttggagatta ttgatcatag cgcaatttac 1927201 gtactcatcg ccggaaccta cacgcctttt ttgcttgggc cgctgaaagg cacactcggc 1927261 tttaccctgt tggttatcgt atggtcactt gccctaggcg gaatcgtttt taaaattttc 1927321 tttgtgaaac ggtttatcct attgtcaacc ttcgtgtatt tagtcatggg gtggctgatg 1927381 attattgcag ttaaaccttt atatgcttca ctgagcggag cgggattcag cctccttttt 1927441 ctcggcggca ttttatactc tgtcggaacc atcttttaca tttggaaaaa gatccccttc 1927501 catcacgcca tttggcacag ctttgtattg ggcgggagcg ctgccatgtt tttctgcgtg 1927561 ctcttctatt gtgtaaaggt gcctttcctt tcgtaacagt aacagaaaag cgcagtcttc 1927621 acgactgcgc ttttttatgc acgtaattgt ttttcattgg caggtatata agcttttgaa 1927681 aaggacaatt caatgtctgc cggttttaag cgtttaaaaa acgagccatt ttgcatgtta 1927741 tctgttcctt tcgtttccac catcaccaac ggaagatgat agcgggccgc aagttctaca 1927801 ggatcaatag aaccatctag tgaaagaatc aggctttgtc ccttttccag ctgttttgtc 1927861 acatcttcat ataccttttc tgaatccccg tctgaaatca catccatccg atccagccat 1927921 tgcccgataa aaggcaagcg gaacactttt gggttagcga taaagccggc cggttcctca 1927981 atatatccag caattaaggc cagttcagcc aaacgcaaac ggggatgcac atacaaaaca 1928041 ggaccgtgtg gtattggctc tggctgatgg atcgtcacaa ctgaaccgga gatgccgata 1928101 cagccttcta aaaacgcctt tggctgttcg tacacaagag ccatctgttt tttgtatgac 1928161 agacggggat cgagcattgt ttgattaaat aattgtttca tattttttaa cagcatatac 1928221 acaatataaa ccactagaag gctgtagcga accaattaaa atcctcccgc tttagaagaa 1928281 ttcttttttt catacattag aaattcgtaa tcatacgggt ttttttcgtc tttggtcccc 1928341 tgctcagaag aaaccagctt ccaattggat tcatcaaatt caggaaagtg acggtcaccc 1928401 tcaaactcgt gatgaatttt cgtcatatac agtctgtccg cataagggaa caggtccgta 1928461 tagagctgag cccctccgat cacaaagcat tcttcagggc ctgaacaaat gtccagtaca 1928521 tcctttaatg aactgacaac cgtgcatccc tgaaattctg aatccggcgc tgaggtaacg 1928581 acaatatttt tccgatttgg aagcggacgt ccgatcgatt caaatgtttt ccggcccata 1928641 atgattgaat ggcccgatgt tattttctta aagtatgcaa gatcattggg caaatgccac 1928701 ggcaaatcat tgtctttgcc gataagcctg ttggcatcca tcgcaaaaat gaatgaaatc 1928761 atacgctgac cgcccctttt atatgaggat gcggatcata atcctcgatg ataaagtcct 1928821 caaatgcaaa gttaaaaata gaatcaacct ttctggcgaa acgaagctgc ggaagcggtc 1928881 taacatctct ttccagctgc aaattgactt gttcaatatg attttggtaa atatgaacat 1928941 caccaaacgt atggatgaac tcgcccggtt caagcccagt cacatgagca atgatcatgg 1929001 ttaggagggc ataagatgca atattaaacg gcacacctaa gaaaacatcg gcagagcgct 1929061 gatacagctg acaggacagc ttgccgtcag acacatagaa ttggaacagg caatggcacg 1929121 gcggcaacgc cattttatca atttcaccaa cattccaggc gctgacgatt aagcgtctgg 1929181 agttcggatt tgttttaata tcttcaataa gacgggaaat ttgatcaatg gtttctccat 1929241 cagctccccg ccaagaacgc cattgggagc catatacagg tccaagttca ccgttttcat 1929301 cagcccactc attccagatt cgcactccgt tttcctgcag atagcgtaca ttcgtatctc 1929361 cttttaagaa ccacagcagt tcatgcgcaa ttgatttaaa gtggagtttt ttagtggtga 1929421 gcatcggaaa gccttcccgt aaattaaatc tcatttgata tccgaaagtg ctgattgttc 1929481 cggtcccagt ccggtctccc tttttctcac catgctctaa aacatgtctg cagaaatcct 1929541 tatactgttt catttttttc atcctttaaa agtagtcttc tagtagtgta acacaataaa 1929601 aaatcatttc tgaacccaga aatgattttt ttatagtcag ctgacgacag gcttttcatc 1929661 ctgttctttt tcttcatctt gcagatcctg atgcgtatgt gcaattctgc tcgccgctgc 1929721 tgcagcaaga gctgccacaa tatcatccaa aaaggtgtga ataccgtctg gactttcatc 1929781 aagttcctta ataattccaa tcttctcttt atccaaataa ccgaaattgg tcaaaccgat 1929841 cgacccgtac acattaacga ttgaaagcgg gataatttca tctatgccgt aaagcggttc 1929901 atccgtttca acaaggtgct gcagcggttc ggggagaagt ttctgttctg caagctgatc 1929961 gagtgcaagg cctgtcaaaa cagcatgaat aatttcacgt ttgttcagga ctttttctac 1930021 attctccatg caaacactga gcggcagatt tggattgtat ttttcctgaa gtttttgaac 1930081 aatccgtgca atatcttcta tcataacgcc ccgtttgttc agcatatcct ttgttatatc 1930141 gaccatttca ttcattgtgt actttttcat gtctaatggc atctccttta ggcactcatc 1930201 cagttgggag gcgtgttgcg gtcccagtaa atgctcccaa gctcatgatg tgattgaaat 1930261 ccatcttctg ctgtatgata atgaaaatta aaccagtagc cgtcatgagg cgggtggtct 1930321 cttcgcacat ggaatctgag aagatcttct ccagttgtcc gattgtaaac gttgaaaatt 1930381 ttttccgttt tgcccgctga aggcatgctt gagatcacaa catcttggta cgcctcatca 1930441 tcttgcaatg tcgctaaata atcactaatc acattttcga tttttggcag gatctctttc 1930501 cgatagtcat cctcaatgac aggagcgatt ctgctgccga attttaaaaa ggactgatcc 1930561 tcagcgctgt caaggagctg ttccttgtac gattgaaaaa gcagttcagg atctcgcctg 1930621 tcatccgact catcatcgta caggtcatgc tcatcataaa aagcggtgta atcattctgc 1930681 tcaagactgc tcggctgtcc ggaaggcttg tccgccataa gggcagccgg aggagatacg 1930741 agcccgaacg ttacaatggt aaataaaacc acaagggtct ttctcatcca caatttcatg 1930801 actgcttatt cctctctatt ttattgtcat gtttctctta ttttagcaca tccaaaacat 1930861 gcaagtcatg tactatatga aactgatatg caaattagga gattcgttgc tatgcacttt 1930921 gtgtaaaaac gcttacaata tttcatgaaa ggaggctttc cgcatgattg acgctctgtt 1930981 tgccacagtt tcactcttaa cattattata ctttgtcgtc atggaggtca ccgattaaca 1931041 gaaagcccgt gatatgaatc acgggcttgt ttgaatgacg ccataatgga acagtgctgt 1931101 ttttcttttc atgacgttaa aaccaaactg ttcaaaccgc gggcttttcc agtggtcttt 1931161 tagcacaacg ctttttctgg cgactcgtac cgcttcattg atacatcctt cgtgcaaaac 1931221 ggaatcctct gccaaatcac gtaaaggcgc gatgccgtca gaggtttcta caggttcatg 1931281 aaacattgga tcgaaataaa ccacatcaac agagttgtca gggagctgct tgatgtgttc 1931341 aaagcaatca ccattcttca cctggattct tctcatcgca gcttgaagct cttctatacc 1931401 cgtttcccat gaatgcagcc ccgtcctcac taaaacagac acaagatggt ttttttcaat 1931461 cccaacaaca gaacccgttt cgcctactgc catacttgcg ataatggcat ctgaccccaa 1931521 cccgagtgtg caatctaaaa acgtatcccc ttcagataag ccggcagccc gaagcatagg 1931581 ttctttctcc ccctgtaaga agcgtttggc tctgaacatc gctgtattcg gatgaaaaaa 1931641 gaatttggca ccttgtttcg tatacagctc aaaccgctct ttgccgacca caagcaaatc 1931701 acgttcagct gatttcagca ggtgctcaac cgtttgttta ttccggccgc agtatggcat 1931761 atttagctct ttagaaagct gctttgcagt ttttatggtg tgttcagacg gtctatagct 1931821 tgttgttatc atcttctgta ctcccaaaaa gaaaatgccc ggagaacggg catttagcag 1931881 tgcgcatcga aggcagcagt cagatttttc atgatttctt ccatatcgtg tccttcaatt 1931941 tcatgacgcg gaataaaatg tacgacttct ttgcctttca aaagagccat tgatggtgaa 1932001 gaaggctcct ggccagtaaa atactcacgc attttcgcag tagcttcttt atcttggccc 1932061 gcaaatacag tcaccgtatt gtcaggtgtt ttgtcattct ggaggactgc ctgtgtagcc 1932121 gcaggacgcg caaggcctgc cgcgcagccg catacagagt taacgactac aagagttgtg 1932181 ccctctgcct tttccataaa gttttctact tcttccgctg ttgttaactc ttcaaaacct 1932241 gctccagtca gctcgcggcg catcggtacg acaagctggc gcatgtattc ttcataagcc 1932301 attgacataa aaaaagcccc ctctagtatc cttcatctga agtaaaggat actatagaga 1932361 gggccggatt tcaaatgttc acgccttaaa ataaaagaaa gtgtccccag ctatctagat 1932421 tttcataata ccgccggtgt tggcacttgt cacaagttta gaataacgtg ccaggtagcc 1932481 ggttttcact ttcggttcaa aacctttcca gttcgctttt cgtttttccc actcttcttc 1932541 tggcacttgt acatccaaga tgcgtttttc aatatcaacg ataatatggt ctccgttttc 1932601 aacaaaggca agcggcccgc cctcagcggc ctcaggtgat acgtggccga ttgagaggcc 1932661 acgggaggct ccggaaaaac gtccgtccgt aatcaatgcc acttttggcc cgagtcccat 1932721 tccaacgatt tgggatgttg gcgccagcat ttccggcatg ccaggtccgc cttttggccc 1932781 ttcgtatctg atgatgacaa cgtcgccttc ttttactttt cggttgataa tgccgtcaag 1932841 cgcctcgtcc tgagaatcga atacgacagc cggcccttcg tgtcttgtaa tcccattctg 1932901 tacgccgcct gttttaatga tagcgccgtc cggagctaga ttaccgaata aaacagcaag 1932961 gcctcccttt tcagtgaatg gttgatccag cgggtgaatg acgtcataat cctttacttc 1933021 atgtccggca atggtttctc caagagtttt tcctgtaaca gtcagcgcat ctaaatgaag 1933081 cgctccttct ttcttcgaaa gctcattcag agccgctgaa acgccgcccg cttcgtgaag 1933141 atcttcaata aacacatccg atgcaggcgc cagcttagcc aagtgcggca cgcgctcagc 1933201 gacttcgtta atgcgttcta aagagtattc aacgccggct tcgtttgcaa gggcaagggt 1933261 atgaagaacg gtatttgtag aacctccgag cgccatatcg agtgcaaacg cgttatcaat 1933321 cgcttttact gtaacaatat cacgcggttt gatatctttg cgaatcgttt ccattaattg 1933381 cgcagccgat tttctcacaa actctttgcg ttccggagat gttgccagaa tggttccatt 1933441 acccggcaaa gcaagaccaa gtgcttctga cagacagttc attgagttcg ccgtaaacat 1933501 gcctgagcaa gacccgcacg ttgggcatcc gaactgctct agttcttgaa gctcgttttc 1933561 gttgattttc cctgcttggt aggcgcctac cccttcgaat actgaggaaa gggagatttt 1933621 tcgcccgtca cttgttcttc ctgccgccat cggtccgccg ctgacaaaaa tcgtcggaat 1933681 gttgatgcgc attgccgcca taagcattcc cggtgtgatt ttgtcgcagt tcggaataca 1933741 gaccattccg tcaaaccagt gtgcggatac aaccgtttcc acagagtctg cgataatttc 1933801 acggcttggc agcgaatatc tcataccgat atgccccatt gcgatgccat catctacccc 1933861 aatggtatta aattcaaacg gaacgccccc tgcttctctg attgcttctt ttacgatttt 1933921 cccaaactcc tgcaagtgaa catgaccggg aacgatatca atgtatgaat tacacaccgc 1933981 aataaacggc ttgccgaaat cctcttcttt tacccctgct gcacgaagca aactgcggtg 1934041 cggagctcta tcgattcctt gtgtgatcat attactgcgt aattctgcca tggtgatcct 1934101 cctaaattct ttcaattgtt tgattggatt ttattttgac aattttcagt ttatttatgg 1934161 gctgtttttg caaataagat aaatacaggc cgccctcacc ttgttttgtt ctttcgtgtt 1934221 tttatattta tatagctttc tttcgatttg aaccctccaa ctattaatat tgttacttac 1934281 tataaatagt tttcggatat ttttcaacaa tattcgaaat aatttttata aaaagtgaat 1934341 tcacataaaa aaggtgcatg atctgcacct tttttatctt tattcgcctt tttttctgct 1934401 ttccgtcatt tgtttccaaa cagaaccttt tgcttcttct ccatgctcaa tacgttcaag 1934461 cgccattttg acttgaaggc tgacctcaaa ttcggggtca tcttcggcag cgcgcaaagc 1934521 ttcaattgca ctttcatcgc cgacttcgta caggaacatg gcggcacgcc agcgaacaag 1934581 cttgctggag tcgcttaatg acttgatcat agcaggaatg gcttgaggat cgccgatatc 1934641 agacaggcag tctccggccg ttcttctgac tgatacagct ttgtcctcaa gtgctttata 1934701 caatagagga agaacatcag gtgtttcaat cattcctaag tacacaacag cctgtcttct 1934761 gatggacacc tttggatcat ccaatgcctt ctgtaaaacc gggatatcct cttctttcgg 1934821 atccatctgt tccaagtgtg cataacgctt tttccagtcc tcatcatcca gcatatcaag 1934881 cgttacttta tacgctttgc gctgtacagc ttgttttgct tcgccctttc cttgagcggc 1934941 tgcttcagtc agtcgtttca gccgttcatc actgtatgcc gcttgaagct cttctgtcac 1935001 atcatggccg atttcatcaa agtcaccgaa tctgacacct tgttctttcc aagcccgctc 1935061 aaacacaaca ttggaagctt cagatctaag ttttaagatc gcctgctgaa agcgttcagg 1935121 taagccgaag cgttcttccc gctctccatc ggttaattta acttgcatag gaatgccgct 1935181 gaacatctgc acaaaaactt ttacctctcc aaaagattct tgatcagaac gattttcttc 1935241 tgcgctttca gcactttcca tcccaaatgc agtgcggact tgcggtaaaa tgtctttcca 1935301 gtcgtatctt gcattccgtt caacagcaag aaaatctgcg acgtgatata cccctttaac 1935361 tccatctatt ttaaggattt ccgctataac aagcggtgcg ccttctgctt gctcaggttt 1935421 atagttattg cttttgcccg ccggaagctc ttccgttaag atgactttca ttgtattcgg 1935481 gcttggtgta ggttcaattg attttatctt catgatcgtc ctcctatagc atatctgtga 1935541 cttattctat catagtcgct ccaagccttc tattacgacg tttcggcatc aatcccgggt 1935601 atgtcttttt ctaattggcg gacaaattga agcataaaat tgtgtctttc ttctgccagt 1935661 tcccgtgcag tgtctgtatt catcatatct ttcagccgca gcagcttatg aaaaaaatga 1935721 gcgtaggcgc tttgctcatc tccataaagg ccatgccctt ttgcgcccgc aaacatgaaa 1935781 gctctcgcaa tgccgacagc accaatcgca tcaagtctgt cagcatcctg tacagctttt 1935841 ccttcaattg agagcggctc cttcgccaat ttccccctgt cccgaaagga catccttgtt 1935901 ataatatgaa tcaccctgtc agcattctct tttcctactc cgaaaaaaac gagctgatca 1935961 tatacttcgc tcacagaaag cctgaccgtg tcaggcagct tcacatcaat taaatcatga 1936021 accaaagccg ccgtttcaac aatgaacaaa tccgcttttt ccttttctcc aatatacgct 1936081 gcaagatctg ctactcttga tacatgatgc cagtcatgtc cagagctttc gtcagtcagg 1936141 atagattgaa cccatgtcct gatttgctct gcctgcttca attccttcac aaaaacaccc 1936201 tctttttatt gctctaatag cttcacgata tcgtcttcca actctttcgg atttgtattt 1936261 ggtgaataac ggccaacgat ttctccattt ctatccacta taaatttcgt gaaattccac 1936321 ttgatcgcct tagttcccag catccctttc gcatgttctg tcaaatacac aaacagcggg 1936381 tgggcgtttt tcccgtttac atccactttt gaaaacatag gaaatgtaac accgtaattt 1936441 gtttcacaaa attcctgtat gtcagcctct tcaccaggct cttggttcat gaattgattg 1936501 caggggaacc ctaagatctc cagcccctcc tgctgatatg tatcatataa ttcctgcagc 1936561 tgcttcaatt gggaagtaaa accgcactta cttgctgtat tcacgatcat cagtaccttt 1936621 cccgcgaaag gctgaagtgt catgtctttc cctgtgattg tacgtacctt catatgataa 1936681 atagacatgt aagtccctcc tatgtccttg gtgctgatta ttttaccttt tttaaatcgc 1936741 aattcaaaat gtaaacatca attaagaact cataagaaac ctaacgatat gagcgtcagt 1936801 tcattatcaa ttcatatggc tcgtttttta tcttatcatt ctataaaaca ttacaattcc 1936861 ctcttacatc tttgaaaatc attttactgt gaaaccaaaa ggcgtgtcag tgcgttttat 1936921 ttaaagagtt ttctgttgtt tccccctcaa cacgtataga tagattgaaa attggcgtga 1936981 aaattcctat aatgaagaaa attaaacggg gaaataatgg aggtggcacg ttgcctatta 1937041 atataccaac acacctgccg gcaaaacagg tgcttgaaag tgaacatata tttgtaatgg 1937101 atgaaagcag agcatttcat caggatatcc ggccgcaaaa aattattata ttaaatttga 1937161 tgccgaaaaa aatccaaaca gagactcagc ttctcagatt gcttggaaat tcgcctttac 1937221 aggttcattt cacattttta atcccaagca cacacacgcc gaaaaatact gcgagagaac 1937281 accttgacga attttacacg actttttcca atatccgtca caagaggttt gacggcatga 1937341 ttatcaccgg tgcgccgatc gagcatttgg cgtttgaaga ggtttcatat tgggaagagc 1937401 tcaaggaaat catggagtgg agcaaaacaa atgtcacttc aaccttgcat atttgctggg 1937461 gtgctcaagc aggtttgtat taccattacg gtgtggaaaa aattcaaatg ccgaaaaaaa 1937521 tcttcggtgt gttcgaacat accgttcttt caaaacacga aagattggta agaggttttg 1937581 acgagctata ctacgtgccg cattcccggc atacagatat aaatatggaa cagcttcaag 1937641 cagtgcccga gttaaacatt cttaccgcat caaaggaagc cggggtttgc ttaattgtgt 1937701 ctaaagacga aaaacaagtc tttttgacag ggcaccctga atatgataca aatacgcttc 1937761 ttcaagagta tgaaagagat ttggaacgaa acctttctac tgtcgaggcc cctaaacatt 1937821 attttgcaaa aggcagcaac gagccagtga atcgctggaa agcgcatgcc acattattgt 1937881 ttatgaattg gctgaattat tacgtttacc aagaaactcc ttatgaatgg gactaatttt 1937941 tcttttttta gtgatacgct gagcaaaaaa tatgataaaa tacatctgat tcagtctgcg 1938001 tataacaaaa atttaaaata ctggaatcca aatcatttaa aattagctta actttttcac 1938061 tgcattaata attcgattat gtatttgtgt tatgtttatg tatagacaat aactccttac 1938121 gatgcatgaa gcttgcttgt tgttgattac attgaggtga atttacttga ataccaataa 1938181 aagagtatta attttgactg caaattacgg aaatggacat gtgcaggtag ccaaaacact 1938241 ttatgaacaa tgtgtacggc tcggctttca gcatgtaaca gtttctaatt tgtaccaaga 1938301 gtcaaatccg attgtttcag aggtaactca atacctttat ttaaaaagct tctcaatcgg 1938361 gaaacagttt tatcgtttgt tttattacgg agttgacaaa atctataata aacgtaaatt 1938421 caatatttac tttaaaatgg gtaataaaag attgggcgaa cttgtcgatg aacatcagcc 1938481 cgatattatt attaatacat ttccgatgat cgtcgtgccg gaatacagac gccgaactgg 1938541 aagagtcatt cctaccttca acgttatgac tgatttttgt cttcataaaa tttgggttca 1938601 cgaaaacgtg gataaatatt atgtggcgac agattacgtg aaggaaaaac tgctggagat 1938661 cggcactcat ccaagcaatg taaaaatcac aggaattcca atcaggccgc aatttgaaga 1938721 atccatgcct gttggcccga tatataaaaa gtacaatctt tcaccaaaca aaaaagtgct 1938781 tctgatcatg gcaggtgctc acggtgtatt aaagaacgta aaagagctgt gcgaaaacct 1938841 tgtcaaggat gaccaagtgc aagtagttgt cgtgtgcggg aaaaatacgg ctttaaaaga 1938901 atctttgagt gcgcttgaag cggaaaatgg tgacaaatta aaagttctgg gctatgtgga 1938961 gcgcattgat gagctatttc ggatcacaga ttgcatgatt accaagcccg gcggcattac 1939021 tttgacagaa gccacagcca ttggagtgcc tgtcattctg tacaaacccg tgcctggcca 1939081 ggaaaaagaa aatgcaaact tctttgaaga ccgcggagct gccatcgttg tgaaccgtca 1939141 tgaagagatt ctcgagtcag tcacttccct tcttgcagat gaagatacct tgcatcgcat 1939201 gaagaaaaac attaaggacc ttcatttagc aaactcctct gaagtgattt tagaggatat 1939261 cctgaaggaa tcagaaatga tgaccgccaa acaaaaagcc aaagtgctat cgtaatggcg 1939321 tacttgagag catacgaaaa tcgtgtgctc tttttattta tattcagcca tcaataaaag 1939381 cggttacatt tttttatgga acttgccctt cttttgaaaa ataagccgtt tcgcaacttg 1939441 acgggtgctc ccagatggtg tatagttgaa ccatcattta acaatgaatc aaagttagat 1939501 gatgacaaaa ttttttttag cacatgggtg ctacagtact aggaggaatt aagcaatatg 1939561 caaaacggta aagtaaaatg gttcaacaac gaaaaaggat tcggcttcat tgaagttgaa 1939621 ggcggagacg atgtatttgt tcacttcaca gctatcgaag gagatggata caaatcatta 1939681 gaagaaggac aagaagtttc ttttgaaatt gtcgaaggta atcgtggacc tcaagcttct 1939741 aatgttgtaa aactctaaac tcaatacatg atgatgagat gacaaataga ggagaggcat 1939801 tcgcctctcc tatttgattt tcatctggat ttcaatcgcc aaaatgtttt gtttacacct 1939861 ctgttcaatc tcttcaacat acttttccat tgatggtttt ccttttttcg cgatatcggc 1939921 cagttcttct aaatcactgt atatttctat aaatgttttg tgaaggatca acttcaagtc 1939981 tttatcatcc atagctgcgt tccccttctc tatcaagata cctcaaatag taaaacggtc 1940041 ctatttattc tggttcaata gttatatcgg cttattttta ttttcttttc tattttggta 1940101 cataaatttc aaaaaaactc tgcaaaataa tggcggaggt gttttttgtg acttcagaat 1940161 ttcataatga ggatcagacc ggctttacgg ataagcggca gctggaacta gcggtggaaa 1940221 cagcgcagaa aacaacagga gccgcgacga gaggccaaag caaaacatta gtcgactctg 1940281 cataccaagc cattgaggat gctagagaac tgtcacaatc tgaagagctg gcagctctcg 1940341 atgatcctga atttgtaaag cagcaacagc agctgctaga tgacagcgag catcagctgg 1940401 atgaattcaa agaataaaaa ccgcagcttc tgcggttttt atttttagtg attggttaag 1940461 acatctccgt attgtttcaa cttttcacca accgtacatt tattgataca aaatgaatgc 1940521 gcataagttt tgccaaattc tttgcgaaac tgcttcttaa taaaacagtc cttgcaatat 1940581 tcatcgtgca gttctgtcag ttctttaaag atcattttct tatccaatat cgtcatctcc 1940641 gttacggtct aatttcgtgt ggctttctac gaattgatgg gatagaattt ttttagcgag 1940701 gccgtcagct tcctgattgt cttttcgttg tattgtttcg taggttggag taagcttcag 1940761 cgattcaagg agtgcttcta ttttgtccag ccattcatta tgagatggat cataacaagg 1940821 ccagctgccg tcaagctgat tcagcacaac aagcgagtcc cctttgattg taattgaatt 1940881 tctgcttgcc ccaagctctc ttacttctct tattgcttca taaagcgctg cgtattcagc 1940941 ttcattattg gttttcagcc ggaagctttt attttttctc aagcgatgcc gggttcctcc 1941001 caatgaataa tagatgacga tcccgagacc ggccagttcg ctctctttat cgaaactgcc 1941061 gtcaaaataa acagtaatgt catcaggctc ttgagcaagc tcctctgtca gcttttccaa 1941121 ttccttcagc gtccagctgc cgcctttctc gtcttcgaac tctagctcct tcatgtatgg 1941181 aaaacggcca agttctctgg cgaacgtacg tgcctgctgt gctgtcagcc agtcttcgct 1941241 aaaaaatgag acggatcccg ttccttttgc ttctattttc aaatgcggtc tgagcttcat 1941301 tacaatcacc ttaccattca ttagttgccg ggcttatgct ataatcaaac caatcttacc 1941361 ccggaaagga agctttttca tcttgtttaa taattcgttt tggatctttt ttgcgatcat 1941421 tcattttatc attgttcttt tattttataa aggatttggc aaaatgggac tgtttgtttg 1941481 gatcggtttt gcgacagtct gcgccaacct ccaagtcgtc aaaacagtcg aactgtttgg 1941541 cttaacagcg acactcggga atgtgatgta tggcacaatc ttttttgcga cagatgtgct 1941601 gaatgaaaaa tacggaccag ctgaagccag aaaagcggta tggctcggat tctcaacgct 1941661 cctgacgctg acatttgtca tgcagggcgt gctgcttttc gaaccggctt ccagcgacat 1941721 atcacaaaca gcgctggaaa cgatcttcgg attccttccg cgagttgcgt taggaagtct 1941781 gcttgccttt atcttcagcc aaacgctgga tgtttatgta tattcggcaa ttagaaggat 1941841 atttccttct gatcggcttt tatggctcag aaacggcggc agtacagcag tcagccagtt 1941901 gtttgataca ttcatattca ctgcagtcgc ctttctcggc atttatccgg cagacgtgtg 1941961 gcttcatatt tttatttcta catatttgat taagtttgcg gtatctttaa tttcattgcc 1942021 ttatgcctat gcagccaaaa aaatgatacc taatgatgaa aggagttcat aatgcctaca 1942081 gaaatatatg tagacggcgc aagcgccggt aatccagggc cttccggtat cggcattttt 1942141 atcaaacatg agggaaaagc agaatctttc tctattccaa tcggagtgca tacaaaccag 1942201 gaagcggaat ttcttgcatt aattgaaggg atgaagctat gtgcaacgcg cgggtatcaa 1942261 tcagtttcct ttcgaaccga ttcagatatt gtggaacgcg ccactgagct tgaaatggtt 1942321 aaaaatataa cgtttcaacc gtttgtagaa gagatcatcc gattaaaagc ggcattccct 1942381 ctttttttca tcaaatggat accgggcaag caaaaccaaa aagccgatct tctggcaaaa 1942441 gaagcgattc ggctgaatga aaagaattaa atcttgatca ttggttcatc ctaatggcga 1942501 ggtgaactaa catgaaaaag aaagataaag gccggctgac cggcggtgtt actccgcaag 1942561 gcgacctgga aggcaataca cataatgacc ctaaaacaga gcttgaggag agagcaaaaa 1942621 aaagcaatac aaaacgctag agaggatcta aacgatctct ctagcgttca gcttttcaag 1942681 catacgctca attcctttaa tttggtggcg gcgaagcatg tcagccgcct gctccatttg 1942741 caaagtaaat aaagcgtctt tcagtgtgca ggccagcggc actgagcaat ggatttccgc 1942801 aagcttcctc gacatctcca aatcgcttaa accttgctga atttttccct gctgtccttt 1942861 tggaagaaga gaaagatttt ccaataaacg gtcaatcgtt tcgtattcac gaatcagttt 1942921 gtaggctgtt ttttctccaa tgcctttgac tccgggatag ttatcactgg aatcacccat 1942981 aagcgcttta atatcaatca aagccttcgg cattacgcct gtttcttcat aaaaagtctc 1943041 ttttgtatag actttataat ttccgattcc tttttgaagc aaagcaacgc ttactttatc 1943101 cgttaacagc tgaagtaaat ctctgtcccc tgttaccacc gtaatgtccg cttcattcgc 1943161 aaataaatcg gcaagagtac cgatacagtc atccgcttca tagccggcaa agccaatatt 1943221 catgattcca agctctgcgg ctgcttcctt tgccaaatca aactgcggaa tcagctccac 1943281 aggcggcgcg ctgcggttgg ccttataatc ttggaacaag tcatttcggt acgttttgct 1943341 ccccatgtcc cagcagcaga cgacgtgtgt cggctggaat gtttccacag ctgtaatcaa 1943401 atgctttaaa aagccgttga cgccgttcgt cggcaccccg ctgtcattta tcataaagtt 1943461 gcgatgtacg gccgtggcaa aaaaggcccg gaataaaaga gccatgccgt caaccagcaa 1943521 tagtttatta ttattcatca aataactccc ttttctttca ttccttctat tttatcataa 1943581 agcagcccaa aaataaaaaa cagtatctct ttaattagag atactgtttg aatatttatc 1943641 aatcgttgtg tcttttgttg ctggcgatca gcttttcagc ttcgcgtcct gcgtaagagt 1943701 caaaatgggt ttgaaatccg tttttctttt tggcgttgtt attcgcctgt gcatttctgt 1943761 ttccgagctt tgttctgccc aacatgaatc cccccttacg tcggatgcat atagtatatg 1943821 cttccggcag gaggttcact cgcgacagga tcatccagct tacatgcggc ttacgtattc 1943881 tctgaccatt tcttttgata caagccgtct tgtcgggacg atgccttttt tagcgagctg 1943941 attcatttgc tcggtaattt cattaattgc atctgtagta taaggctcat cgtttctgca 1944001 tttagcaaca gcttcttcaa tcgccaattc acgcatattt tcaagacgca taaatgcttt 1944061 gatatgctcg tgctgttttg atgaatgtgc tgaaattgct ttatgtacct ctgacattaa 1944121 tcgttcatct cgcttttttc tatttagtct atcatgactt gaaatacaag ccaactgaat 1944181 tttacatttt tattgtattg tctgaatttt tccaggagat gcacgcctga tacgccattt 1944241 caatctcttt cgcatgttcc ccttccgcat atcctcttaa atatgtctct ttttgatccg 1944301 ttatttgcgc gattgctttt tcacccatat cttcctgtaa gcgtctgagg tgagcagtgt 1944361 aatgagatat caggctttct tcttcatttt ttatccatgc ctctgtgatt ttcgtaagtt 1944421 tcatccgtac agcttcgata aaggtcgctt ttcctttctg ctcaaaaaac tgcttcggtg 1944481 atttgatctc ttttagttcc tgctcaaaag cacgttcttc tatttccggt tcaacttcct 1944541 tcaactgtat gccgttcgaa tgctgatcac ccgcataaac ggaaaaataa ccgtcctcgt 1944601 ttaatgtttt ttgaaaatga tccagccatt cttcattgat atgccgttcg atgaaaccgc 1944661 tcatgcgaac atcaagcgtt ttgatttcct gaatatattc aaatagatat tcatgtaagg 1944721 ctgttgtcat cgctttactg acgttctttt tccaatcccc gttttgcagc ccgggatgaa 1944781 atgccgattt taataaatca tttgcaaaat atgataatcg ctgtgcaatg tgatatagct 1944841 gctctcttgt atcttttttt actttttcaa tgatggtttt tgagttccgc cgtttctcga 1944901 tatcggccgc tgtccgctca aatgacagca taaggcactg tttctgcgct tccttctctt 1944961 ctcgggactg atgctgggat tggtgaagct gaaaaacagt ttcgcatagt ttgtctgcct 1945021 ccgaactgag ctgcgctgct gacgcttttt ttacatccac ttcgataaac cggtctaagt 1945081 gttttcttac tttcgagaac tgattataaa atgactccgg ttttcccacc agttcctcct 1945141 tacttgatac ggtaaagagc tgcggctcat aaaccccttc ttttacaagc tctgcgctga 1945201 cataatcggt cactgtttcg agctctgttt tatcttttgc aaggtctgca gcattaataa 1945261 taaaaaacat tttatccatg ctgagcgatt ctttcacaag tccaagcttt cgcaaaaatg 1945321 aacggtctcc ttttgaaaaa gagtgctgat aataagtcat ataaaaaaat gcatcagcat 1945381 ctttgatata ttggaatgcc agttctgtat gccgtttatt catgctgctc gcgccgggtg 1945441 tatcaacgat cgtaatccct ttttcagtga gcgggcatgt atagtagacc gttacctctt 1945501 tcacagcaca ggccgttgtt tcctctgcta catacggctt taattcagag agcggaatcg 1945561 ttaatttctt ctgttcctgt atatactgct gatacttctc gtatgcaagc aggaaattgc 1945621 tgatcaattt cacgtgttct tcctgcagcc tgtttttttt gactgccttt tcccacttct 1945681 ctgtgaagga acggcctgcc ggctcctttg gtattccggt gagctgcaaa atttcagccg 1945741 ttaagtcatc ctctgtctta aacactacat tcgctgtttt gtttaagttg ccattgattg 1945801 gctttgtgat cttgttaatt gtcgctgtgg ttggcgttgg tgaggatggc agcactcttt 1945861 cgccgacaag cgcattggca aatgatgatt tccccgagct aaagcctcca aaaagagcga 1945921 gtgtaaattt ccgttcctca agccttttca ccctttcacg aaacgctgaa gtttgcttta 1945981 acaacatgct gcattcgcct aaaatgtcag acaaagtgta aaagcgtttg atttggtctt 1946041 gaagcggcat ttcttgttcc attttgattt ctgatttcgg catcggctgc gccgtcagct 1946101 ggcttcggcc ttgtttctgc tctggagccg ccactcttgt tttcttcgat ttaaaccatt 1946161 ctgtgtctat atgcattggg catgcggact cttcttccca aatggcccac aggcgatcgg 1946221 ttttctctcg ggcattattc tctaaacgtg cctgttcttg aagaaagaca agtttttctg 1946281 attcttggac gagccggtcg ttaattgttt gcacatcttt ggaaacacgc tctttcacca 1946341 tagcggagag cacctttatg atgtctgcgg cttctctttt cgcctctttc cggatgagct 1946401 ctgccaagtc ttttgtatat tgcaatacat attcagagga aaaggctgca ccatgcttga 1946461 ccgcgtgttc aatgatgctt atatcaagcg gtgtgcgata ggcctgaatc agcttttcac 1946521 tttcagcggt atagacatca aataccttgg cgagtttatg aagcgtgtct atcatatgcc 1946581 aatccgcttc ggcctctgtt cgttttgcca catcagagaa aaaagcattc cgccttttat 1946641 ctctttcctg tgcagttttc gctttagaaa agaaaaagcc ggttttaaag gaaggctctt 1946701 gtgattctaa aaatgcagcc gccaattcac gcatttcaaa aggcgtcagg ttggcgtttt 1946761 ttaaaatacg attgatttct tcctgcatcc tcttctctgc ctcagtcatt tgtttttcgg 1946821 cctcatccaa ttgatcacgc agcgattgga ccagtccagt atggatatta agctgttcag 1946881 cgaaactcgg agcgcctgtt tcgtctttct tcagcatttc cgtatgttcc tttagcagat 1946941 tacggacttt ttgttcggtt aaagcctgca tattgctttt tgattgctgt tctattctgc 1947001 ttaactcttc tctcagggcc cccatctgat tgaacgggtg atccggttct gttactgatg 1947061 taaaatagag cgcttccctt gaaatccctt cattgcaaag catctcctct acctgcgctt 1947121 gatagtctcc aaatttcgtc tccgtctcat catggcggtc aatttgattg acgataaaat 1947181 acacattcgg aatgctttct tttattgatc tgagaaactt tacattttcc tcagcgtgca 1947241 cgtgattata gtgaacgacg taaaacagcg catccgcttg gtgaagaata gaagcagccg 1947301 atagaaaatg cgcatcatct gttgaatcta tccctggagt atcaatatac gcaaccccgg 1947361 aatcgatctc agtatacctg tcaaaaattt cgacgctttc aatctgttcc ccgtctttac 1947421 aatattgctg caccttgtct ttctggtaag tcccttccag ctcagcacac gctccgtctg 1947481 ttgtatgaag ccgaactcgc ttttccccgt ttctgatcac aacaaggtta gcgcttgtcg 1947541 gaatcgggct tgtcggcaaa atattctcca ttaacaggca gttcagcagt gacgatttcc 1947601 ccgctgaata atgcccggta aacgcgatat aaacctcttc atcagccgct tttttcatga 1947661 ccgcagccag tttagcagcc ctttgttcat cttgattctc aataaattgc ttataaagtt 1947721 ccccggtttt atgcaaaagc tcttttctgt tttgatctgt cataagtctg aacccctttg 1947781 tgccgtttca attgtgaacc tttttcgaaa gatctgaatt cattcccttt tcattttaca 1947841 caagaataaa ccaaatttct ttaggagaat agaaaaaagc cgccattacg gcagcttcta 1947901 taaaagaaaa tctgcaactt ttacaagttc cagattcatc aaacagattt attagagatt 1947961 ccttttaata caaaaccaat taatacacta tatgtacaaa ccgctccaag caaaaacagc 1948021 attgtcattt gcttcaccat cctgattgag aatctttttc aaacccattt taacatggtt 1948081 gagaatgatt ttcaatcgct attttacgct gtattcctgt aatgctttgt cttctgcgcg 1948141 aattctgacg cttaacaaca cggcattgaa aatggaaaac agacacatgg tgacgtatgc 1948201 ttgataaagc agcggaatca gcaaaatttc gaggataaca acggcatagt ttggatgttt 1948261 catccattta tatggacctt tttttacaag ctctacacct ggaacaacaa ggattttcgt 1948321 attccaatat gctcctaagg aacaaagcgc ccaataccgt acgatctgta cgcttaaaat 1948381 cactgcagcg ataccgagcc accagctgga cggctgttta ttcatcagca gcacctcggc 1948441 aattaaggac aggaaaaaaa ggatatgcat cgtaatgata tacggatagt ggctctcgcc 1948501 aaattcaatt gctccttgct tctttacctt ttgttcgttt tgcctggcca ctgccatttc 1948561 tgctgctctt tgaacaatga gaatggcgat caacaaccaa aacatgagtc aggccccctt 1948621 ttcccagctg aataatagca actctgatga gaaacccggc cctaatgcgc caatcagtcc 1948681 tcgttcagct tcctttttat gtccgttctg cagatggtct ttgatcacat acaagattgt 1948741 ggctgaagac atatttccgt gcttttgcaa aatgctttgc gcagatgaaa gcttttctga 1948801 cgacagcccg agacttttga tgtatgcatc gatcactttt tttccgcctg gatgcgccaa 1948861 aaaaacactg atatcatgga atgacagctt atgtttgtcc aaaaaaatct gtacatttgt 1948921 tttgagccat ttttccacca aggtcggaat gtctcgtgag aaaatgactt tgaatccttg 1948981 atcggtaaag tcccagccca tgacatcttc tgattgtttc atcaaaacag attgggcgtc 1949041 cattatcttc ggcgcaagct tcagctttga caccctgcgg tccgccttct ctccgcataa 1949101 taaagctgcg gcaatgccgt caccaaaaag cgaggtgccg atcagattgc tttttgtttt 1949161 atcttccggc tggaatgtca ggctgcacag ctcggcagaa atgacaagca caaaagcctc 1949221 aggatacgct ttgcagtatt cggctgcacg cgcaagtccg ctggctcctc ctgcacagcc 1949281 aagcccccaa atcggaatcc gcttcgtata tggagaaaac ggaagttcat tcataagccg 1949341 cgcctcgata ctcggtgtgg aaagacctgt actggagacg aaaaaaacag cttccacttt 1949401 ctcataagga atggcttctt gaaaaaattc cggatgagag aggcactcac gaacagccgc 1949461 tctgctgtgt ttaagtgttt cttctatgta tatttgattt ttttcttcaa agctgtgccc 1949521 ctctttatac cattcaatcg gcttaacaaa ctgtctcgaa tggatttgcc cgtttttaaa 1949581 ggaggataac agcctgtcaa tatccttaaa agaatgctga aacatatagc gggcgaactc 1949641 ggccgctttc tcttggttta cattatacgc aggaagactt gttccaatgg ataaaataaa 1949701 cgccatgcga tcacctcttt gcatacattg tgccgcaaca atctttttta tatgcaaaaa 1949761 aaactccgcc gcggcggagt tagactgctg ttttttgttc agcgaggtca gcttcttgtt 1949821 ctattttttt agctttagaa aaaacgttat atacaatatt taagacgact gcagtaaagc 1949881 tgcccgccac aatgccattc gttgtaagca gcgttaaggc actcggaagc tgtttgaaaa 1949941 tatccggcac aacggtcaca ccgagcccca atcccactga gcaagcaaca atcagcagat 1950001 tttcctgttt cgcaaaatca atgcggctga gcattttaat tccgtaagca atcaccattc 1950061 caaacatcgc caccattgca ccgcccaaaa cagcggatgg aataatagtc gtgaaagcag 1950121 cgatctttgg aaacagccca aatgccatta ggatcacacc tgtgaccaca atgacggcat 1950181 tttttttgat ccctgtgagc tgaacaagcc cgacattttg agagaatgcc gtgtaaggaa 1950241 aagcgttaaa aataccgccc agaagcacag ccagtccttc agctcgatag cctttagaca 1950301 aatctatctc tgtcaaacgg cggtttgtca ggtcacctaa agcaaagtaa acaccagttg 1950361 actccacaag gctgacaatt gcaacgatgg acatcgtaat gataggcgct gcgtgaaaag 1950421 acggcgctcc gaagtaaaat ggctgaatca tttgaacaac tgccgcgtcc gaaacattat 1950481 caaattgaac ttttcccata aaatatgcga tgaaggtgcc aatcaaaata ccgatcaaaa 1950541 tcgagacgga cttgataaag ccttttgtaa aacggtatag aagcacaatg atactcaaca 1950601 cggtaaaagc aagtgcaaga ttggagagat ctccgaaatc tgcacttcct tctccgccgg 1950661 ccatgttatt catggcaacc ggcatcagtg taataccgat aatcgtaaca acagagcctg 1950721 tcacgaccgg cggaaaaaac gatacgagct ttccaaagaa aaatgaaata agaatgacaa 1950781 gaatgcctga agcgataatg ctgccgtaaa ctgttgaaac cccatattca gatccaatcg 1950841 ctatcatcgg cgatacagct gtaaaggtac agccaagcac taccggaagc ccgatcccaa 1950901 aaaatcggtt gctccacact tgcagaagtg tagccacacc gcacataaaa atatcaatcg 1950961 atactaagta agtcagctgc tcgacagtca gtcccattgc ttttccgaca atcagaggaa 1951021 cgacaatggc gccggcatac atggcaagaa catgctgaat ccctaaagac agcgttttgc 1951081 cgaatccatt tctcatgaat gaacctcctg tacgaaggac acttttcctt cttctaaaga 1951141 ctgaattctt gccaaagatt ccactcggta gcccagtttt acaagttcat ctcttcccgg 1951201 ctgaaatgac ttttcaataa caatgccgat tcccgcaata gaagctcccg cttgcttcac 1951261 aatcgacaca agcccgtgcg ctgcctgtcc atttgccaaa aaatcatcga taatcagcac 1951321 atgatcctga tccgacaggt gggtcccaga cactgcgatt tggctttctg tttgcttcgt 1951381 aaaggaataa acagacgctg tcagcaagtt gtcggtgagt gttaacgatt tatgctttct 1951441 cgcgaagaca actggcacac ccagcttcaa gcccgtcatt acagcgggag cgatacctga 1951501 tgattcgatt gtcacaattt tggtaatacc gtcttttgca aacctagacg caaattcatc 1951561 accaattctc tgcataagca gcggatcaat ttggtgattc aaaaaagaat ccactttcaa 1951621 tacctgatca gataatacga cgccttcttc ctctattttc cgtttcagtg cttccatcct 1951681 gtctacctcc gttatgagaa taaaaaaagc attgcccgct caaataaaga gcaagcaatg 1951741 ctgatatcac aaaaaaccgt acacgtgcgg ttccattgct cacccatagt cggacattta 1951801 cggtgcccgg tagaaacttg cgtgccatat ccacgcgatt atatgagtgt tcctattata 1951861 ttgtaataaa ttatatcaag attctaatct cttgcatagg ctgaaaataa aaattcccga 1951921 actttaattt tgttttttta gatatcattc gtatttcaag gggattcgat ataaaagagt 1951981 ctgacgaccg cgccgccagg cttttgatta taacagatag agatttgaat atttgtttga 1952041 taaataatca attaaatagc gaacattcag ctcttctcct gttgcatctt taataatgtc 1952101 taacggcttt ttccgttttc cgtgaatgtg caccttttcc gtcagccatt gctttatcgg 1952161 atggaactct cctctttcca agagagcgtc aaattcaggg agatcctcaa gcattttttg 1952221 tttcagctga gccgcataca tgtagccgag cgcataggat gggaagtagc cgaaatctcc 1952281 acctgcccaa tggacgtcct gtaaaatccc ctctgcgtcg gtctgcggtg taatccctaa 1952341 ataatcctgg tatttttgat tccaaagcga cggcagatct tccacagaca cttcattgct 1952401 gaaaatcgct ttttcaattt cataacggat gatgatatga agaggatacg tcaattcatc 1952461 cgcttcgacc ctgataaatg aaggttttga ttcattgatt gcccggacaa aatcatccag 1952521 ggagatgtcc ttgaactgta caggtgatgc ctcttgaatc ttcttatagt acggagtcca 1952581 aaaatgcttg ttgcggccga taaaattctc gtaaaataat gattgcgatt catgaattcc 1952641 catcgatgcg ccgtctgaca agttcgtgcc actgagtgct tcatcaatat tttgctcgta 1952701 aatcgcgtgc ccgcactcat gaatggtccc aaagatcgcc gtccggaaat ctttttcatc 1952761 atatctcgtc gtgacccgaa cgtctccccg attcagcgta gttgcaaacg gatgaacggt 1952821 ttcatcaagt cttccgccat caaaatcgta gccaagctcc tgtaaaaaat acagactgag 1952881 ctctttttgc ttttctttcg ggaacgcttt tgtaataaag cttgtatctg gtttatttcc 1952941 ggaagctgtc acctgtttaa caagagggat aatcgcttcc ttcagctcag caaacaactg 1953001 atcaagcacc tttaccgtga cgccgggctc aaacaaatca agcaatgcat cataaggatg 1953061 ctcttgatat ccccaatacg taataaaacg tttattgaat tcaatcagct gttctaaata 1953121 aggagaaaac aagctgaaat cagattttcc tttcgcttcc tcccacgctg tttctgcctt 1953181 tgaacacaga atcacgtatt ctttgtattc agcctcaggg attttcttat tctcttcata 1953241 ctcttttttc gccagttcca ctgctttttt cgtatcttcc gacaagtcat caaatcgttc 1953301 atacaggaca tcgataagct ccttcattcg atctgatgtt tggatattga atatatctgt 1953361 tgaaagctgg ccgatacttt cggcacgatc ctctgagcca tttttcggcg cgcctgttct 1953421 ggagtcccag tgcattaacg caactgcttc gctgtaatgt gagattcttt ttaaaagatc 1953481 aaaaaattct ttttcatatg tatgtatctc catatccatt ccctccctat tctagccgtt 1953541 ccattacagg ctaatggaag ggggtatgaa agtcaaattg tttgtataaa aggctgccgg 1953601 tatgttttgt ggcagccttt ttattcagtt gatcgtcatt tgattttttg gcggaggtgt 1953661 tctccgcttt ttctgcttga tttttttatc tacccacact gttgccagcg gggttaagag 1953721 cgaggtgaca ataacgcttg tcgcgataat tgcagttgcc gactcagcaa ctggcgcaaa 1953781 tgaggcattc gcttccgcta atgcatatgg cacggctaca gccgcccctg ccgtagaaga 1953841 agcggccact cccgcgacac catctccccg cgcaataaaa cgatcaagca aaaacaaaga 1953901 actgcccgat aaaatgacga cagaaactcc gataaaaatg ccgagcagcc ctgattggat 1953961 cagcattcca aaattcaagg tattgccgag cgaaaaggcg aaaaatggaa tgatcgccgg 1954021 cacaaccttg ctgaataagt ctctgagatc atgatccaga tttccaagta tacatccaag 1954081 taaaaacggg atgactgtcg ctgccagcgt ttcccatggg aatgcggcaa gtcccgtcac 1954141 accaaacgtc accatggtca taaaaggacc agattctgta ctgataaagg cgaaagcgcc 1954201 cgcatcctct tttcttccca tgtgattcat gagcgccaaa tacagtccgc cgttcgtttc 1954261 attcattacc gcgacaattg ctaaaacaga aaggcctgca aaaaagccgg attgtatgcc 1954321 atcgtcaggt ataaattgcg ctgcgatcac gccgagcagc gccgcaaatc cgatcttccc 1954381 caataataac gtgattcctt ttcttgcgat atagcctgaa gaacgaaaat caatcgttgc 1954441 tcctacgcaa aagataaaaa cacccagtat cggcagcgtt ccggtaatca aagcacccgt 1954501 aaaccctcca aagaactccg ctgttccagg cgcaaacgtg ttgagcgccg ctccaagaaa 1954561 tagcggaata atcatcattc cgccaggtac ccgttcaatt gtcgccttga ttttcatatt 1954621 gtggattctc ccatcctccg gttatgaaaa aacaattcca cttacacttg gaaaacagcc 1954681 tgcaaatcct cttttgaaca gctgcccaac tggctgccga ctccgacggc gccagctccg 1954741 gctctaagcc aatcaggcac ttcagacgga tgtatcccgc ctgtcggaat aaaggtcacc 1954801 tgcgggaaag gacccgctaa atttttcata aacggaatgc caaacacacc gcttgggaac 1954861 agctttaatg tcgtaaaacc gaatgtcagc gcttccataa tttcgctcgg agtcaagacg 1954921 ccggggatat aatgtgtctt tacaaaagat agatgttcag caagatcagc tgaaaaaccc 1954981 ggactgacaa taaactgcgc gccagcctta gcagcttccc cagcttgctg cgcgctgatg 1955041 accgtacccg cgccaattaa aatatcttcc ctattacgga aggattcgat aatatctgat 1955101 gccccggggg tcgtatacgt cacttcaact gcacgaatcc ctttatctaa taaactctca 1955161 atctgctgac aggcctcctg cttatccttt gaacgaatga ctgcaatcag ctttgcttct 1955221 ttcagacggt tttcaacgac tttggactcc atattaataa tcccctttct tttggtgaac 1955281 cgttctttga gcagataaaa aagaagctaa tttctccctg gtcggcaaac cgtccatatc 1955341 ccccggtgcc tgcacttgca aagcgccaat cgcatttccc ctttgcaccg catccttgta 1955401 cgacaaaccg tctaggatac cgctgattac accgactgca aatccgtctc cggcgccgac 1955461 cgtatcaacc acccggtcga cccggcagcc ttctagaaat ccttcacttg tccccgtttt 1955521 aaagtaagcg ccttcttttc caagtttaat agcaacaaag ctggcacctt ttttcaaata 1955581 atagtcggca atgccttcag gtgttttttc tccggtcaat agctctccct ctgcgatacc 1955641 cgggaaaaac cagtctgcaa gcccagccag atcattgatt gtgtgtacca ttgttgcttg 1955701 atcaggccaa agcgaaggtc ttacattagg gtcgaatgaa atggtcttcc ctgcgtttct 1955761 catgtcgttc atgacatgat acgtgaagtc tttcatctcg gctgataaag caggcggaat 1955821 acctgtcaca tgcaaatggc ctgcgcattg aaaataatct ctcggatatt cagctgtagt 1955881 taatgtgctt gcagctgagt ttttcctata gtaggtaact tgcgggtcgc cttctttcac 1955941 ttttgacttc agcagcagcc cggtgggatt ttcgtcctgc gagcggatca cgcgggacac 1956001 atccactccc tcttttttaa gctcttgtaa aataaacgtt ccgagctgat cattgccgac 1956061 cttgctcatc catcccattc gaaatccgag tctggcaagg ccgcaggcga cattgctttc 1956121 tgctccggca agccctttag aaaaagtgga tacttcatga aggcctccat actcatttgc 1956181 ataaaacatg gccattgatt ccccgaatgt caccgcatca agcttcatct cttcccaacc 1956241 tcctcttagt tgagggcacc taggattaaa gtgactttct catgatgact tttgcctcta 1956301 attcaatggt ttgaggcgct cctttgtcac cttcaatcct ttttaataca cgttccatcg 1956361 ccgtcctgcc catatcatgt gacggctggg cgatcgttgt aatgcctgga ccgatcagtt 1956421 tgtaccactc cgtatcatcg aatcctgcaa tccctatatc ttgagggatg cgcaggccaa 1956481 gctcttccat acagctgatg attttcagca taatcaagcc attcaaagcc agaatcgctt 1956541 ttttttgctc cggcatttcc ttgtgaaaag aacgaagctc cgccttaagc tgctccttgt 1956601 cctttacgtc aatttcatgc aatctgacaa gcccgttcac attttgaacc gaagccattt 1956661 cctgatacac agctgctctt tctgcacgag ggctgataga ggaaatcggt tcggtaaaca 1956721 gcgcgacatc agtataccct ttgctgtaca ccttctgaag aatctctttt gtgatccatc 1956781 tgttgtcagt cgttacggta tccagtttca gatccggcag tttccggtca attaagattg 1956841 ttggaatttg ctgttcagca aaagcgcgga gtacatcctt gttttcccct gttgcgttta 1956901 aaatcaagcc ctcaaccgaa tgggcttcta gctttaagag catttcccgc tctttttcag 1956961 gactgttatc tgtgttgcac accataatgc tgtatccata ttgatcacaa acctcttcga 1957021 ctcccctgaa agcagcgacc gaaaaaggat ttgtaatgtc agccacaaca aatccgatta 1957081 acttgctttt ttttattttc aaaccttgtg ccattttact cggccgataa ttcaattctg 1957141 cgattgcctt tttaatgttt ttcacttttt caggagaaat cgcgtcaatt tttccgttaa 1957201 tatagcggga aactgtcgat ttcgaaactc ctgcacattc agctacgtct ttgatggttg 1957261 tatggcctgt tgttttcttt ttcattcaag tgctcctgta tctcatatat ttgaaaccga 1957321 tttcaaaacc gttacaacaa aagaatacca taattttaaa atttgggaag agttttttta 1957381 ataatatgtc aattcattat tttttcgttg actcttttca ctatttatcc taaaattttc 1957441 tttgaaaccg ttaccaaaat attttcattc aagtgatgct gaaatcctaa ccaaggggga 1957501 aatataatgg aaaatcgtta ttctgtacat cctgaacaag taaaacgctt tacaacagag 1957561 gagcttcgca gtcatttctt aatggattct ttatttacag aaaacaaact tacgatgtat 1957621 tactcacatg aagaccgggt tgtcatcggc ggagcggctc cagggcaaag tgaactgaag 1957681 cttgatgcag gtgattttct aaaaacagac ttctttttgg aacggcgtga aatcgggatt 1957741 attaatgtcg gccagcctgg tgccgttaga gtcggcgatg atgaatatgt gcttcaaaca 1957801 aaggattttc tctatattgg aatgggcaat caggatgtat cgttttcaag cctgaacggg 1957861 gaaaaagcga agttttactt cgtctccgct tgcgcccaca aaagctatcc gacacaaaaa 1957921 gccgccctat ctgaactgac accggaccgc cttggtgatg atgcagcgtc taatgtcaga 1957981 agtctgtaca aagtcattca tcaggatggc attaaaagct gtcagctgat gatgggaata 1958041 acgatgttag atcaaaacaa caactggaat accatgccag cacacgttca tgaccgtcgg 1958101 atggaggctt atctttatct ggatcttgaa aaggactcaa aggtatttca tttcatgggc 1958161 cagccggacg aaacacgcca tcttgttgtt ggaaatgagc aggctgtcct ttctcccgct 1958221 tggtctattc attctggcgc aggaacatca aactatagct ttgtgtgggc gatggctgga 1958281 gaaaattaca catttacgga catggatctc attccaatgg atgggctgaa ataagatggg 1958341 ttatctacat gacgcctttt cattaaaagg aaaaacagcg ctggtgacag gcccgggaac 1958401 agggatcggt caaggaatag ccaaagccct agccggggct ggcgctgata ttatcggcac 1958461 atcacataca agcagtctgt ctgaaacaca gcagcttgtg gaacaggaag gccggatatt 1958521 tacatctttt acattggaca tgagcaagcc ggaagcgata aaggattctg cagctgagct 1958581 gtttgaaaac aggcagatcg acatccttgt caataatgcc ggcattattc atcgggaaaa 1958641 agcggaagat tttccagaag agaactggca gcacgtactg aatgtcaatc taaacagcct 1958701 gtttattctg acacagcttg ctggcaggca catgctgaaa agaggtcatg gaaagattat 1958761 taatattgcc tctctcctgt cttttcaagg cggcatcctc gttccggctt acaccgcgag 1958821 caaacacgct gttgccggtt tgacaaaatc atttgcaaat gagtgggcag cgtcaggtat 1958881 tcaggtcaac gcaatcgccc caggctatat ttctactgcg aatacaaagc ctattcggga 1958941 tgacgaaaag cgaaatgagg acattttaaa gagaattcct gccggccgct ggggccaagc 1959001 ggatgatatc ggggggactg cagtcttttt ggcatcacgt gcttcagatt atgtaaatgg 1959061 acatatttta gcagttgatg gcggctggct atcccgctga caaataaaaa agctgacgaa 1959121 cgatcgtcag cttttttcca ttacatcatg tgcggttcaa caggcaagac ctttttgacc 1959181 tcatcaatga tgcgttcatt ttctccgcca gcgtaaatgt gaatcgagcc gctgtcttga 1959241 ttcgagcgaa tcaggcgccc gatgccctgc cgtacacgta acaacatata tggcagatca 1959301 acttcttcga acggatcttt tttcgctccg ttgcgcttcg ctgtaaatac aggatcgtgt 1959361 ggcgggaacg gtaatgacca aatggtaaca ttcttcaatg cgtcaccggg aatgtcgagt 1959421 ccttcccata agtgaactga acaaagtact gtttcttctt cctcttggaa tttctctact 1959481 aagctgctga tttcctcatc accttcgaag aaaattggat acggcagctc ccatgccgcc 1959541 gacagctctt taaactcgtt taattcttca aaagaaggga aaagcaccag cgttcttcct 1959601 ttgtatcgtt tgattgtttc aatcgtttca gccgtttttt gttcagcgtc catatctgtt 1959661 tttgcgtata gattaatact catttgctcg tcataatcat aaggggaatc aacagttaat 1959721 gacaaataat catgaatccc aagactgtcg gcaatataat caaacgaacc gccttctgac 1959781 agcgtagcag aagaaaagat ataaggaatt ttcttagaaa acactttttc gccaagtact 1959841 tctgctaccg ttctcggcat cacgacaaag gttgattctg cttccttttt ctccagccag 1959901 ctgatcgcat ccttttgata tagagataat gaatacgcca tttgttcaac atattcttcc 1959961 actactgaca gttcgtattg atcaatcgta tacatttcag actcaaatac aagtgcctca 1960021 ccgattttat caagtaaacg gcaaagctcg tccgccgcct ttttgacacg atggtcattt 1960081 tttatttcta aacggtgtga accggctact tcctttgatt cttcagaaag aacatagaaa 1960141 aattcgtcgt ttgcgagaag cgcatcttca atcaattctg caaactcttc tctgatgtca 1960201 ttttgcagca atcgttctaa aaacaattca agagtagact gcttcactct ataggttagc 1960261 gctttttgcg cagcaaactc taacaagtgc ccctcatcaa atacaactgc actatgatca 1960321 ggcaagagcg gcagctggcc ctctcgtttg cgtgattctt ccgtccacac atgctccata 1960381 taaaaatcat gggaacaaat gattaagtcc gttgacttgc ggtagtaatc tctggaaagt 1960441 gtcagaccgc atctgtgtct catatcacaa gtcagacagt cctgaaacga gtcgtagctt 1960501 acgtcagacc actcttcatt cgatagattt gcgtactgct tacggtcgcc atacggataa 1960561 aagcgctgca tcgcctggga ctcgtggaca aatgacggta acgactcata aagatccagc 1960621 catttatcat catcagaacg ctgcattgtt ttttcaagct tcttcaagca taaatattgc 1960681 tcatgtgatt ttgacagcct tgtatcaatt ttcagatcaa gatgctcagc cagcttagaa 1960741 atatcgccct cttttttcac cagctgttca attaatgttt catccgcaca agcgatgatg 1960801 gcaggtttgc cgacatacct tgcatagctg attgcaaaaa gaagatatac cagcgttttc 1960861 cccgttccca ctccagcttc ggcgaacatg acttttttct ctttaaacgc ccgctccagc 1960921 tgaaaagcca taaatacttg ctcgtcccga agatcaaacc ctttttcggg aaggatatcg 1960981 taaaacacgt caccaatcca attgttcaat tcttcataaa aattctttgt tttcgttaaa 1961041 gaaaaaggca aacgtgatgt tgtcacctag ttccaacccc caactattcg acattcagac 1961101 caccaataat atcattttcc gctgatgaat acaataaaaa acttggcaat gccaagtttt 1961161 ttgcagttta cttacgattg atcacatgcg acgataaaaa aggatggtct gttgaataaa 1961221 tatgttctac cgctttttct aaatcagttt gcgcatgcga aatcacagac ggagacgaat 1961281 cagtcccgag ctccttcagc tcgtttgctg ttgcgtcaag cgccctttga ataagattaa 1961341 aatgttcgct gttcagcatg agatcacctc tgatggaaat aatcatcatt gtatgcgaac 1961401 ttttcatttt atatacatgc tttaccgcat gttatcaccg aaacatgcac aaactacact 1961461 tgatattccg tctccggatt atccgtctta tcaacaatat tctatcaggg agtgatgttg 1961521 acatgagtta tagaaaccga ttagatcagc attctgaact gtttcatcac aattggacgc 1961581 ggcctaaacg ttcaaagtct caagtaaacg gtcacactga aatgtcccaa accaacatta 1961641 tattgagaag caacgcgaaa gctcaccgtt ggtaacgata gaatagggct gaaagatgaa 1961701 agaagacgca tgcagagcgt cttcttttta tgcgttttct gttttcttgc gctgcggtct 1961761 tacttttgac cagtattgat aataatccgt tttaataaac ccgttaaaga gttttcgttt 1961821 cttcgttgct tttctgccat atgcttcctc aaagttttca tttgatgtca gcatatacac 1961881 agaccaagta tcaagcggct cgaacgcctg ccccatttct ttgtacatct gctcaacggc 1961941 ttttttctcg ccgagacgct ctccatatgg cgggttgccg acaattacgc caaattccag 1962001 atttgtggta aagtctttga cctgcatctg tttgaactgg attagatctc ccaatcctgc 1962061 ttcctctgca ttttcttttg cgatttgaac catgcggtgg tctatgtcgc tagcgaaaat 1962121 tgtaagcggc tgatcataat ttgccttttc ttcgacttca agccgcgctt tgttccacag 1962181 atctttaccg atccattccc aatcctctga tacaaaatcg cggttgaatc ccggggcgat 1962241 gttttggccg attagcgccg cttctatcgc gattgttccg gagccgcaga aaggatcaac 1962301 aaacgggcgg tcaggcgtcc aattggttaa ttgcaccaaa gcggcagcaa gtgtttcttt 1962361 aatcggcgca ccgccctgat cgacacggta tcctcgtttg tgaaggcccg tccctgatga 1962421 gtccagtgta atcaaagcct gatctttcaa taaagatatt tccactttat actcagcacc 1962481 tgtttcttca atccaatcat tggctttgcc ggactgcagc ttgagctttt cgacaattgc 1962541 ttttttgacg atccgctgac agtcaggaac gcttgcaagt gttgatttta ccgattttcc 1962601 gatgacaggg aatttcccgt tttcaggtat aaatgagcgc cagttaatcg ctttcgtttt 1962661 ttcaaacagt tcatcaaatg ttttcgcttt aaaagaagca acctgaacct ttatgcggtc 1962721 ggctgttcta agccaaaggt tcgcacggca gatggcaagt gcatcacctt caaaaataac 1962781 tttcccgtta tcaaccttgc attcgtatcc taaatctcgt acttcctttg cgacaacagc 1962841 ttcaatgccc atcggcgccg ttgcaattag tgtatacttc ttcatcgtat caccctgtct 1962901 tttaaaactt ttctcttttc aagataaaag ctctccttat acgggagagc ttgttttcat 1962961 cattttaaat gtaagtggtc taacgttctg taagccatgt tttgttccat cgtactgcaa 1963021 acggctcatc acctcgtact caggcggcaa tcatctatct acagaaagca ttctgtcctt 1963081 ctctccgttg aattccgtta agaaggttcc cctaccaaaa tttgggtttc tcgctcgagg 1963141 ggtttaccgc gttccactct caccatttct agtgagactt cgtcactgtg gcactttcaa 1963201 ggatactcag ccatatccga agacgtaggc ttttttcctg ccgtcagcct ctaaagactg 1963261 ccctagctta tgacttcgct aggcacgaac actacgggca tctcagcacc gtgcgagcat 1963321 ggactttcct ctacagattc aagatctgca gcgattaccc gaacgttaag aacatgaatt 1963381 attatataac aactgattac aatttacaag cgccattttt ttcaagcgtg atcaatcata 1963441 aagcttgctg ccaaaaacgt gtttttctaa gttagacagc cgttttaaaa tatcaaagtt 1963501 tgttgtgtta gattgcacag gctgtttttt gctggcttct tcaagctgtt ttttcagctg 1963561 cagattttcc tgctgcagtt cttcaatttc ttgatggaag gtttcataat ccttaataat 1963621 catatctaaa aatttgtcaa cgtcttcttg cttgtagcct ctaacgcctg ttttaaattc 1963681 tttttccaaa atttctttcg cagaaagctt tactttatca gcaagcatct ttttcacctc 1963741 gtatcgtgaa tcatcacata tattttttca gaaatctgta cggttgtcaa atttctctct 1963801 cattgttagt agctgtcttc ctccactgtc actctcaagt catccattgt aataaagtag 1963861 atgggatagc catcctgttc gcgccttttt tccgctgtcc caagcatata cttaggggag 1963921 ccttcctttt ccgggtcata taaaagcaga agcccgtcgg acttatcaat gaagaactga 1963981 tttttttgtt tgaattgaag cgggctttca taaggacggt gagtcaggct tgcttcatag 1964041 tctgcctgag ccagaactgc ttcatactgt tctttattcg gttctttcca gttcttttcc 1964101 tgctcgtaaa atggtgtgat gacagctacc tttaagtcag ggtattcctc ctgcaaatca 1964161 tatgcagctt ctgccgccca cagctcaact ccaagctggc ccgaaattaa aatccattct 1964221 aatccttcat ccaaaaaagc aatcagccgg tttttaatgg ctttttttat gtaatacagc 1964281 gccttgtcat cctgcttaaa tatccccagt tcaaacggtt tatagcccgt tattgccaat 1964341 actttcatca tttcacctgc tttaaaaaat ggggctcccg tgggccccat ttgttgtgct 1964401 gcattgttta caccatcaag ctgcacgttt tccatactag tagtcgcagc aaggttttcc 1964461 tgcttgaaaa tgctgatgcg tagccgggtc aacatttgag aaagtgtgtg gaaagtagtg 1964521 aacgtgctga aaatgctggt ggtttacgtt tgttgtatgc tgtgggtgaa tgtgcggcac 1964581 gatagtcttc gaaaacgtat ggtgttcaca gcaatgagta ggatggacaa ttggcgccat 1964641 catatgcggt ctgcagtgat gcatgataaa atcccctttc cataaacttt attacaatac 1964701 taagttatga aaaataaggg gtacatgttc tgatgcaaag acctatttta aaagtgtgca 1964761 attaagctgt ctttaaagtt tgaaaacaca aaagcaatca aaaataccac aacaaagaac 1964821 aagtaaaaaa cacccttata cataccaact ctccctttaa aaataactaa cgtcatttta 1964881 caggattcgc cgctattcta caacaaaatc aatgtgaatt cagcaaaaaa aattcatggc 1964941 gaaacaagtc gtcttttgcg ctttcccggg gaatatttaa gaggaatatt tcctctttag 1965001 ccgggcaatt ctcacatgca gtttttcagt ttctttctct gataagcatg ccgcatcgct 1965061 aagcgattgc tctgctactt gcaatgcttt tccgaattct tttttcttat gctcaaaata 1965121 tttcgcgagc tctattacag cagcgtatct gcacttctgg ttttgcgagc gggacagctt 1965181 ttcccaaagc ggcactgctt cttccaagcg gttttgtttt ttgtacagga gcgataaatc 1965241 cagccgtgca ctgtcctggt cctcaaacga tttttctata agcctttcca actgcttgat 1965301 cgcttggtcc gtttctttat gagccataaa ccatttcgcc atagcatagg cttcactgtg 1965361 ttcttttggc gcatgtgatt ctgaaaggat ttttttagac atatggatgt acaatgaaat 1965421 gagtgataac acatccattt cattatgatg caggacacct tttaaaagat ccggctcttg 1965481 cgccttgata aaatgaaagt aaagcattgg cgccaagtag cccggtgtgt cttctagcct 1965541 gcggatgccg agctcctctt tttcaaccgt gccaagagat acacggtcca ttttgtgttt 1965601 ccacaggcgt ctagctccat gcaaaagatc aaagtggcca aactccggaa gcttcggaag 1965661 tctgtcacgg atcaaggtgt gccttgtttt cacctgcggc caatcaaagg ctttgccgtt 1965721 gtaggtcaca agtgatgtaa tgtcaacctc gcttaaaaag ctttggtaca aggcgacttc 1965781 gttccccggt ttgggcaaaa gatgctgttt gactgtcact cggtcttcat atactctcgc 1965841 atgcccaagc aaaaaaatgg tattcccagc tccaccccca agaccggttg tttctgtatc 1965901 aaagaaaaag aggttgtttt tgttataccc ttttgctgac aatgtatgcg acaggccgct 1965961 ttgattccac agtgtgatca cttcctcaag ctcagaaaag ctgtataacc catggcggtg 1966021 agaaagcgga tattctactt ctctgatgag gcaatattca tcttcgaaga tgaaaggctt 1966081 catgccaaaa gcctcccact cttctaaaaa cgggatgtca tcaaagtggt tttcttgttt 1966141 gcctgcttct attttttgtt ctccttcgtc gagcgccatg tgctttttca tccgttggag 1966201 tttccctttt aatgacatat ccggcctccc tccttacgac atttgatcca acagctgcaa 1966261 aattctttcc tttgctttta tcccttctat ttccgtacct atacaagacg gacagccgtc 1966321 atgacaagga caatgtgtaa tcagttgttt cgccgcttca ttaatgtctg aaaaacgttt 1966381 aaagacttcc tccgccaaac cgataccgcc cggataatga tcatataaaa atatggttgg 1966441 caatccggta tgggctgctt taatttgaga aacaacatga acatcatttc gatcacacat 1966501 gatatacaca gggacaatat gctgcagcac attcgagatg ccaagaagca gctgttccag 1966561 tgtcttttcc ccgatgtctt catccgctgt tttgatttcg agccaagctg cacttgtatg 1966621 cagttcttct tccggcaaat gaataggtcc agacccaata ttttcaaaag tggtcatttt 1966681 tattttttta aaaatggtcg gcagggcatt gacagtgacg tctccgtagt gcaatgacgt 1966741 acggcttttt tctttcgttt tatcgatttc taataccttc agctgaactg ccaggtttgc 1966801 atccgtataa tattcgacat cgacttttct gacatacgcc tttttatggt cccaatcgag 1966861 cttctcaact tgatactgaa cgccttcatg caaataaatc gcttcatcat gcaaaagcgt 1966921 catcgcacta aaacggtcca tttcaccgat aatccttaca tttgcaatat ccgactgatc 1966981 aactataacg acattttcct gggaggcgga acgcaaactg atgtttgacg cagggaacga 1967041 ctcacttgcc caatggtacc gttcgccgtt gcggtgaaga acagcctctt cctgaagata 1967101 ctcaagaata tcactgactt ccatggctcc aaattcttca tcagctctaa aaggaagctc 1967161 ataagccgca cactttaagt ggtctactaa aataatcaaa ttctccggat tgattcttgc 1967221 agattccggc gaacgattaa agaaatattc aggatgccgc acaatatatt ggtcaatcgg 1967281 tgttgaattg gctaccatga taatcaaaga ttcaccgtgt cttctgccgg ctcgtcccgc 1967341 ctgctgccaa gcacttgcaa cacttccggg ataccccgtc attacacaca cttgcagctg 1967401 gccgatatca acaccaagct ctaaggcatt cgtactgacc actcctaaaa tgtcgccttc 1967461 tctcagtcct ctttcgattt ctcttcgctc tttcggcaga tagcctcccc gatagcctct 1967521 gattgatttt gttccaatct cttttttcac aagctcctga atatggctta aaataatttc 1967581 cacccgaact ctgcttctgg caaaaacaat ggtctgcact ttgtttttaa ggaactcttt 1967641 cgccagttca ttcacttctg cggttgcgct ccttctaata ttcagcggtt tgttcacaat 1967701 tggcggattg taaaacacaa aatgcttgcg tccgctcggt gcgccgttgt catcgaccag 1967761 ccgcatcggt ttgcctgtca gctgctctcc caattccttt gggttggcaa tcgttgcgga 1967821 agtacaaata aaaactggat cacttccata aaaccggcag atccgcttca gccgccggat 1967881 cacatttgcc acatggctgc cgaacacacc tcgatacgta tgaagctcat cgatgacgat 1967941 atacttaagg ttttcaaaca aactgaccca tttcgtatga tgcggtagaa tggcagaatg 1968001 cagcatatcg gggtttgtaa tgacaatatg acctgctttt ctcacctttt gtctgattgc 1968061 cggagacgta tccccgtcat atgtaaagct tttaatatca atgcccattt catcaataat 1968121 ttcatttagc tcgctctttt ggtcttgtgc cagcgcttta gtcggaaata aatataacgc 1968181 ccggtttgtt tcatcttggg cgatggactg caggactggg aggttgtagc ataacgtttt 1968241 tcctgatgct gttggcgtta cggtaacgat gctctctcct ttttgcacat attgaaaagc 1968301 ggaatattgg tgagtatata gttcatcaat gccccttttc gaaagggccg ctttgattct 1968361 ctcgtctata ctttcgggca taggccttgt ttttgcttcc cgaggctcaa tttcatgcca 1968421 attcacaacg ttttcatttc cttttaaatc agaaatgagt tcagtcagtg atttcttttt 1968481 cattctttac acctctttgt caagtacagt ttaccgaata tttgtttgca tggctaggtg 1968541 caaattttat acagttgaat aaaaaaagca aggcatacgc cctgcttatt tcgcttttat 1968601 tgtaaagagc tttgattcgc ctttacgagc agccttttcg cctgccgata ccattgatcc 1968661 tacagcctca ccattcatta taacgattgg gatgactgtg ctgctcgctt tttcttttat 1968721 taattccaaa tcacatgtaa tcagcgggtc accgaccttc actttatccc cttctttaat 1968781 gtgggcagta aatccttctc cgttcatatt gactgtctcc agcccgacat gaattaacag 1968841 ctcaattccc gagcgagtcc gaatgccaac ggcgtgtttg gtgtggaaaa tctgaatgac 1968901 ttcaccttca gcgggagaaa cgatttcacc gctagaaggt tccaccgcta ttccttctcc 1968961 catcattttc tgtgaaaaaa cagggtccgg tacatctgac aggtccatta ctgtaccgtc 1969021 tgccggagaa taaataacct cttctgtcac cttttcctga attttgccca ttccgaataa 1969081 ttttttcagc aatgtatttt ctcccttctc attcacttca accgttatcc cttcattcac 1969141 cactatttaa ccacactttc aattttgctt caatttataa caacatctgg catagacgca 1969201 taatctggtt aaaaaaggcg gtggcgatat tggaattcca tgatgacaaa aagaacgaac 1969261 tgcaaaagaa agaagaaatc ataacggagg caatcgacac tctttttcaa tcctcagcgt 1969321 tcggcaacct tataaacgga tttcagaacc taatcaactc gagtttaaag gatgtgcaga 1969381 cgaccataca tgtcagagaa agagatactg ggctgtatat cgatattacc attccggcga 1969441 cgtttcgaga tggcgagatc gtcgttgatg ttaaatcgag gtatctccat gtaacactcc 1969501 aagaaaaaca gaaacaccaa aatgaggcta cctttacaag catgacaaga acggttcagc 1969561 tgccttatga agttcgccaa gaagatatgg aaacgtcttg gaacgagcag acaatgacac 1969621 ttttctttcc aaaaaataag catgaatgaa cgattcattc atgcttctat catttaaaaa 1969681 agctggtaaa tccctttatt aaagatccga cctgattcat tgcactcatt acttgacctg 1969741 tcgtatccat cattttatta aaatcaaatt gcccattggc ttttttgaac tgcgacataa 1969801 tgctttgaaa ttgtgaaggc tgctgttgat taggccttgg gataggataa gggttagaaa 1969861 atacaggcgg ctgcataggc ataggctgga tcggagcata aggctgataa taatcctgct 1969921 gtccataatg ctgctgaggc agttgttgct ctaaataacc gggtgcagcc tgctgataat 1969981 atccttgcat atgctgagga taataatagc ccatttgccg aggatagctt cgagagctcc 1970041 cgttcattgc gattcccccc taaacacaac atatttctct tctatatatg tatgaatgac 1970101 ttctattgtt tgtgtcacaa gtgatgatta gcatttgtca aattgtgtcg aaagtttaaa 1970161 ttttttaaaa acagaaaaaa gtcgaatcat tatggtacca tattttcaat acagatgaga 1970221 ggggatgcac cataatgaac gtatcatact taagcaaacg ttttgcagaa atgaagaaat 1970281 atgaaacaga ctgtatgaat aaactgatgg actttgccaa gttcctctat attcaaggac 1970341 atctcagcat aactgagttt cgtaacagta tgaaggttct cgaagcaaat ggagcagaaa 1970401 gcccggcata tgagatgaat taacgtccgg ccccctataa aaacgaaaag aagacagcct 1970461 tttaccggct gtcttctctt gcaatttcat cctttactgc gtgcaatgta taaaggactg 1970521 actcagtgat gtccttgaat cgttttttat gaatatgatg aacataagat tgaaggacca 1970581 attccaggaa attatccttt acggcctcaa tttgctcttt atgcacatat tttggccggc 1970641 ggacttttat caattcaaga gcaccctctg cccagcgagc agccagttca tcattctctt 1970701 caactgcagg ctttatcgtc tcaaaaaaat cataagaatg attactgttt tttccttcct 1970761 gataccgatc agcgcctttt tcagcaactt caatcatttg ctcggtcatt tccagcaaag 1970821 tttgtgatag caatatcttt cacctcaatg cctatcgtac caaatttcac tcacaaattc 1970881 agccgatgcg gtataccttc tcaaacgcat acctgtgttc aggcgattga tacagctcat 1970941 ttatacaaat atgaagatct atgatttctt cttcgagcac acttaggcga tcgttctccg 1971001 tttcccgcat ctcagcctct aatgcattta cagaatgatt caggctttgc tcagctcgcg 1971061 ttaattcatc ttctatatca gaaagcatac ggagaatatc tgtcttgcat acataaccgg 1971121 acattcgtgt acctcccttt ccttgtctct cccggttaac attctttgct ctcaaggctc 1971181 tttccttcct catgacaaaa ctagaagcaa atcgccaaac aaacaggtat tccacgaaaa 1971241 gctgaagttt tcgacaaaaa cacccgcaaa aattgtatga tcctcctcat taatgcaaac 1971301 gatacttgtg aggaggtgcc gtatgaaaac aagaccgaaa aaagccggcc agcaaaaaaa 1971361 gactgaatca aaggcaatcg attctttaga taaaaaatta ggcggcccga accgcccttc 1971421 tacgtaagaa gcaaggaatt tccttgcttc tttatttttt cagccactgc tccaccgcaa 1971481 aaagcgcatg aagctggcgc tttttatgta aataccagtc tgtcaattca atctgcttcg 1971541 gcaattcctc gcgcctaaag aacgttttct ttatctttcc atgaaaccaa tctgttttcg 1971601 ttccgtctaa tgagtggatt aactcagggt agcatgtcct tagcatagga gatgttcttt 1971661 ttgtaatccc gatcatcttt tccatatcaa aacgggaacc tgtgtgcggc actgtgtgca 1971721 aaaagtgata aaaagaggag aacaattctg gcttgaacag caattgagac agctgctttc 1971781 ccagccttat cctttcctcc gcctttgaaa agcgtttcac tgaaatgccg taaaaaaacc 1971841 catttgagga aggaaaaata acggtgttaa aatgaaacca gtcacttaaa taaaaaggaa 1971901 tcgtgtcaaa aacattcttt ttaaacgaag gattttgtat aataggtgtt tggatagtgt 1971961 tttgttcatt tataatgagg gcatacatta gccgctccgt atttcgctca tgccaaaaac 1972021 gggtccattc ttccgacata aattgtgaga cgccaaacac atgcagcaga tgaaacagcg 1972081 gtttcccaac tctttttgac cagtggtata aaagaagctg cggataggca tccgaaaaaa 1972141 taagccagtt cgctctttca taggctaaaa agaaccattt ttgctgtctc tcacggagtc 1972201 caagctgaaa cagactgcct tttaagtcag tcattgacca gccggcatta cgagaaacga 1972261 aagaagccaa aagcgaccat ttgatttccg gatgacggtc gtaaaatgct ttataagcat 1972321 ttgttcttga aatgttatcc gcgtttttca tttttgtctg ccgctcaatc cggctcagaa 1972381 gctttctgat ggcctgttgt tcttgcacgt tcattcactt ccgtcatgat tagtttaata 1972441 aggaggatga gaaagtgatt cggtatccta atggaaaaac atttcagccg aaacattcgg 1972501 tttcatccca aaacagtcag aaaagggccc cgtcttacag taatcgcgga atgaccctcg 1972561 aagatgactt aaacgaaacg aataagtatt atctgacaaa ccaaattgcc gttatacaca 1972621 aaaagccgac acctgttcaa attgtaaatg tccattatcc aaaaagaagt gccgcagtga 1972681 ttaaagaagc ttactttaaa caatcatcga caacagacta caatgggatt tacaaagggc 1972741 ggtatattga ttttgaggcg aaagaaacga aaaacaagac ctctttcccc ctgcagaatt 1972801 ttcatgacca tcaaatcgag catatgaagc aggtaaaggc tcaagacggt atttgttttg 1972861 ttattatatc cgctttcgac caggtttatt ttttggaagc cgataagctg ttttatttct 1972921 gggacagaaa agaaaaaaac ggcagaaaat caattcgaaa agatgagttg gaagaaacag 1972981 cttatccgat ttctcttgga tacgcaccca gaattgatta tattagtatt attgaacagc 1973041 tttatttttc gccatcatct ggtgcgaaag gttgattaac gaaaggttga gatgttatgt 1973101 cagatcaatt taacagccgt gaagctcgac gaaaagcgaa cagcaaatcg agtccttcac 1973161 cgaaaaaagg caagaaacga aaaaagggcg gattgtttaa aaagaccctt ttcactttac 1973221 tcattctgtt tgttttaggc gtagtcggcg gtgctgttac atttgccgtc atggtttctg 1973281 atgcgccgtc ccttgatgaa agcaaattga agacgcctta ttcatcaacg atttatgata 1973341 aaaatggaaa agagatcgcc gaagtcggcg ccgaaaaacg gacctacgtc tcgatagatg 1973401 aaattcccga tgttgtaaaa gaagccttta tcgcgacaga agacgctcgt ttttatgagc 1973461 accacgggat tgaccctgtc cgtatcggcg gtgcattagt tgccaacttt aaagacggct 1973521 tcggggctga aggcggaagt acgatcaccc agcaggtcgt caaaaactcc cttctttcac 1973581 atcagaagac gttgaaacgg aaggtgcagg aagtatggct ttcgattcag ctggagcgca 1973641 attactctaa agatgaaatt ttagaaatgt atttaaaccg gatttatttt tctcctagag 1973701 catacggaat cggaaaagcg gcggaagaat ttttcggcgt tactgattta agcaaattga 1973761 ctgtcgaaca ggctgcgacg cttgcaggaa tgccgcagag cccaacagcg tacaacccgg 1973821 tcaaaaaccc ggataaagcg gaaaaacgac ggaacatcgt actcagtctg atgaaaaagc 1973881 aaggatttat ttctgattct caatataaca aagcgaaaaa agtggcagtg aaagacgaag 1973941 gcgtcgtgtc acagaaggaa tatgaaaaag caagtacaaa caaatacagc gcatttgttg 1974001 aagaggttat gaaggaaatt gatgaaaaat ctgatgtcga tccatctgct gacggattaa 1974061 agatctatac gacattagat acaaaagcac aagataaact agatgaatta atggacggag 1974121 acaccgtcgg atttactgaa ggcatgcagg gcggtgtgac gcttctcgat accaaaaacg 1974181 gagaagtccg agcgattggt gcgggacgca atcagcctgt cggaggcttt aactatgcta 1974241 ctcaaactaa ggcacagcct ggttcgacca taaaaccgat tttggactac ggaccagtta 1974301 ttgaaaataa gaaatggtcc acatacgaac aaattgatga ctcagcttat acgtattcta 1974361 acggaaaacc gattcgtgat tgggaccgca aatatctagg gcctatctca atgcgttacg 1974421 ctctggccca atcaagaaat atacctgctt taaaagcatt ccaggcagtc ggtaaagata 1974481 ctgctgtaga ctttgcaaat ggactcgggc ttggtttaac aaaagataat gtaacagagg 1974541 cctattctat tggcggtttc ggtgggaacg atggtgtttc tcctctgaca atggcaggtg 1974601 catacagcgc gtttggaaat aacggaacgt ataatgaacc gcattttgta aaatctatcg 1974661 aatttaacga tggcacgaag cttgacttaa caccaaaatc aaaatcagcc atgagtgatt 1974721 atactgcgtt tatgattaca gatatgctga aaacagctgt gaagacaggt actggacagc 1974781 ttgcacaagt acctggtgta gaagttgcag gaaaaacagg aacgactaac tttgatgata 1974841 atgaagtcaa aaggtacaat atcgctagcg gtggcgcccg agattcttgg ttcgttggct 1974901 acacaccgca atatacagct gccgtctgga cgggaatggg agaaaacgag gctggaaaga 1974961 aatcactttc agctgaagag caaaaagttg caaagcgcat cttcgcccag ctcatcgccg 1975021 atgtcgatga cggaagcgga tcatttgaga agcctgacag cgtagtggaa gccaccgtag 1975081 aaaaaggttc taatccggca aaactggcag ggccaaatac gccaagcgat aagaagctca 1975141 cagagtactt tgttaaaggc acagctcctt ctactgtttc taaaacatat gagaaagaag 1975201 aaaaagagga aacagctaaa ctgtctggtt taaacgtgaa atacgataaa gacaatcaat 1975261 ctttaacgtt aagctggaat tacgacggag atgcgacctt tgctgttaag caatctgttg 1975321 acggcggcag ctactcggaa attcaaaaca gctctgcaaa agaggcagtt atttcgggtg 1975381 tgcagccagg atctgtatac aaattcgaag taacagccgt cagtgatgat ggcaaaagta 1975441 cagcttccac atcttatgag gtgccaaaag ctgaagacga tgaagataaa aaagaccagc 1975501 aacaaacgga tgatgaaaaa caagatgatg agaagactca ggatgataca caaactgatg 1975561 attctcaaaa agatgacggt cagacggatc aagatcagac agatgattca acaaacgatc 1975621 aagacaaaaa acaagacaat acgaacacca atccgtccga caacaataac caagaccaat 1975681 caaacgataa tgataacgac aacagtaaca accaggatac gtcggatggt gattcgaact 1975741 ctggtaagaa tgattcaaca ggttctgaca cgaataaaaa taaaacagac acatctaata 1975801 aaacacaaac aaactcatca tccattgaaa aaacaaatta aacaaaaaag ccgtcacctt 1975861 tggggtgatg gcttttttgg tacacaataa aaaacctccc gttttaacag gaggttttat 1975921 cgattcatcg catgatattt ataaaaatgc tttttcattt cggtaatcag ctcatcaagc 1975981 tgaataaagc aatggtattg ggtcggctta agaagaataa attccactcg ttcagcccaa 1976041 ttaatcggct ttgcgggata tgatttctcc ctcagttctt gccaatcgag cgatttcacc 1976101 ggctcacctg ctgtccaatg taacgaagcc agcaaacaca caatgccctt taacatttcg 1976161 ttttggtcac atctcgattt tcgtgtttga aagactggga gaagtgatgc tttgatgtca 1976221 tcccacactt caaataaaag cggaacgtat ttcccgctgt cctcccatgg caaatcgcct 1976281 tgtaattccg tgcagaaatc aaaatacacg ggattggtct gcaaggtttt cttcatatcc 1976341 gaggaactct tctggccaag actgcgcaag tattgctcat aggaagccaa cacttctttt 1976401 gcttgcgtca tcgtttcacc agtccttttt tatccctctt ctgcccttct ctgcacaaag 1976461 aaagcagcgg acactccgca cagcgcggag attgggcttt acagtgatat ctgccgaaga 1976521 aaataagccg gtgatgcgta acggaccaat cttctttggg aaccttgcgc atcagcgtct 1976581 tttcaacttc cagaaccgag tccttccacc ggcaaatgcc caatcgtttg ctgactctct 1976641 ccacatgggt atctacggct atggccggca cgccaaacgc aacggatacc actacgtttg 1976701 cggtctttct cccgacccct ggcagtttga caagctcatc gcggtctctc ggcacttctc 1976761 cgccgtaatc ttcaataatc attttactca gcttttgaat atttttcgct ttattacgat 1976821 ataaaccgat tgatttaata tcctgctgaa gctcttccag cggaacagcc aaatagtctt 1976881 ccggccgttt atatttttgg aataatgttt tggtcactct gtttacaagt gcatctgtac 1976941 attgcgcaga taaagcaaca gccaccacta attcaaaagg attggaatga accagttcac 1977001 actccgcatg aggaaacatg tcacctatct tgtctaaaca gaattcaatt tgttttagat 1977061 ttaacacgat tgtcaccttt tcactttatt gttcaagcca attgtaaaaa ggaacctgcc 1977121 ttttatactc tttttgcggt tcattctgct ttgcttgtac acgccggaat ttttggctgt 1977181 gtatttttgc ctgctccaca gttttaagcc catttttctt ccattcaaac aaaatccggt 1977241 caatgtagcg gaaactgagt tttcctgata gtacagcctc ttttaacgcg tgtttgatca 1977301 gttgtgcgtc atgctgatcc tggtcctgcc agatcgccag cgtttcacac tccaaaggcg 1977361 ataacggtct tgcgaactct tcctcaaaaa tggtataaag gcttttttgt tccccttctg 1977421 cttttctttc ctgtgtttga ttctgtgcaa gctgaatata ctcgtacagc ttgccccata 1977481 aaggctgaag agaatatttc tcaaatttga tgccgttttg atcctcgcat tcttcaataa 1977541 acagaaagcc tttttgaata aacatccgca atctgtttgt acattcttca acagaaattg 1977601 acataccttc ctgcagctga ttcggtgtag gaaaatatga tcctttttct aaatgcattt 1977661 taatttttaa cagcagaata agttctgttt cattaagccc aagctgttta taatgcgtga 1977721 gcagaagatt ggggatggtt gatgttccct gctcctgcat atcaataaat tgctgttttt 1977781 tcatcgtcac acctcttact gtaaaggatt gtgattgccc ctttactgta aaaagtctcc 1977841 cttgcaggag actctttttt gtttcatttg aatgtattac ggatacagac ggtttaacag 1977901 tcttgggaac ggaatcgttt cacgaacgtg aggcgctccg ctgatccaag ctactgtccg 1977961 ctctaatcca aggccgaagc cggaatgagg aactgatcca tattttctaa gttcagcata 1978021 ccatttataa gcgtcagaat ccagtccatg ttctttaaga cgcgattcca aaagttccat 1978081 atcgtgaatc cgttcagacc cgccgatgat ttctccatag ccttccggcg caatcaagtc 1978141 agcgcaaagc acaacgtcct cacggtcaga agccggctgc atatagaacg gttttaagga 1978201 cgtcggatag cgagtgatga ataccggttt gtcataatgt tcagcaatcg ctgtttcatg 1978261 aggcgctccg aaatcatctc cccactcgat atcgtcaaag cctttttctt tcagaaattc 1978321 aatcgcttca tcatacgtaa ttcttgggaa cggggctttg atttgctcaa gttttgacgt 1978381 gtctcttccc aatgtgttta gttcaatttt gcaattttta agaactgatt gcacgatgaa 1978441 agaaacgtaa ttttcctgta cttgaaggtt ttcttcaaat tctacaaacg ccatttccgg 1978501 ttcgatcatc cagaattcga ttaagtgacg ctttgtttta gacttttccg ctctgaatgt 1978561 cggtccgaaa gagaatactt ttcctaaagc cattgccgca gcttccatgt agagctgtcc 1978621 gctttgagac agatatgcat cttcatcaaa gtactttgtc gcaaagagtt ctgttgttcc 1978681 ttcaggtgcg cttccagtca aaatcggcgg atccactttt acgaagcctt cgttattaaa 1978741 gaattcgtaa gtcgcgcgaa tgatttcatt acggattttc atgatcgcat gctggcgctt 1978801 tgaacgcagc cataaatgtc tgtgatccat caaaaattcc gttccgtgtt cttttggtgt 1978861 aattggataa tcggtcgctt cgtgaatgac ttcaatatct gtcacagcaa gttcatatcc 1978921 aagcggagaa cgctcgtcct ctttgacaat cccttttata tagagcgacg tttcctgcgt 1978981 cactgattta gctgtttgga aaatgctttc ttccacttcc gcttttacta cgacaccctg 1979041 aataaaaccg gtaccgtccc gaagctgtaa aaacgcaatt ttcccgcttg aacgcttatt 1979101 agcgacccaa gctccgatcg ttacttcctc acctacgtgc ttgtacactt ggttgattgt 1979161 tgttttcaac atatttccct ccaaaacaag aaagacattc ggaagctcat tgccccgcga 1979221 actcttttat catcacttta ttatacccgc tcttaactaa ccgggtcaat gcagataaaa 1979281 agcggctttt ctgtcagccg ctttttgatc tgttagctat gtttttctac aaaacgcttg 1979341 attctttcaa tggcttcttc aagaagatct aacgatgttg cataagaaag acggacattc 1979401 tcaggagagc caaatccgga tcctggaaca atcgcaactt tttcctcctc gagaagcgct 1979461 ttaacaaatt catctacatc tttgaaaccg caagattgag ctgcctcttt tgcatttggg 1979521 aacaagtaaa aagcaccttc cggcttcacg cagctgaacc ctgggatttc tatgagcttt 1979581 gcatagatcg tatttaatct atgttcaaat gcttctctca tttcttccaa tggctcagaa 1979641 ggcccgttat aagcagcaat cgctccgtat tgtgcgattg atgtcgggtt tgacgtgctg 1979701 tggcttgcaa ggttcgtcat cgctttaata atgtcttcag agcctgccgc ataaccgatt 1979761 ctccagcctg tcatgctgtg ggacttcgat acgccgttta taatgaccgt ttgctctttc 1979821 agtctgtctg acagctgtgc aatggaaaca tgtttctttc cgccgtatgt aagtttttca 1979881 taaatttcat ctgacacaat caagatatca tgttcaaggc acacttcacc gagcgcagat 1979941 agttcttctt ccgtatacat gacaccagtc gggttgcttg gagagttaat aacgattgct 1980001 tttgtttttt ccgtaattgc atttttcagc tgctcaggcg aaattttgaa gtgattttcc 1980061 tcaagccctt ctacataaac aggctttccg ccagcgagtt tcacctgctc cgggtagctt 1980121 acccagtaag gcgttggaat aataacttca tcttcttcat ccaaaatcac ttggaaaagg 1980181 gtatacagag catgtttggc accagtgcag acaataattt gagacggttt gtattcaata 1980241 ttctggtcgc gtttaaattt ctctgcaatg ctgtttttca gttcagccaa accaccggaa 1980301 ggcgtgtatt tcgtatggcc ctcgttcatc gaacgcacag cggcatcaat aatatgctgc 1980361 ggtgtattga agtcaggctc gcctgctcct aagccgatga catcatggcc tgcggctttc 1980421 agttctttcg ctttcgctgt gattgccagt gtggttgatg gtgttaatgc ggatactctt 1980481 tttgccagtt tcaacttgaa ctccccctaa ttcgtcttaa ggcgtgatat ttttgagaat 1980541 ctttccagtt gtaaagtcca cataacttaa actgtattgc ccttctttgt ctaagtacgt 1980601 cacttcccaa agcaggacgt ttccttctct tgccagatga acctcttttt gctttgaaac 1980661 cagcccttca tcctttatga ttttcgccgc tttgtcttca gagattccct ctttcgcttc 1980721 ttttgagaga atttttgctt ttttatcagc aggaacccag acatataatg cagtgccttt 1980781 tttatccgtt ccctttacaa cataatattt ttcttttccg acaaatgttt cgacttgatc 1980841 aacatgggcg agatcggttt cttttttagc ttcagcagct gctgcttcgt gcccctcttc 1980901 cttttgtgcc atggctgatt tataaatgct tgccgagaca agaagtactg ctaaaaaaat 1980961 aataccaaaa atgacggtaa atattaatgc tttttttctc atcttctcac ctacgtacga 1981021 taaatggtaa aaacggcttg gtttttgttt tcttcatcca gcgcaaggcc gaacatcaga 1981081 ttgtctcttt tcagtgtacg attcaatgtg tccacaattt tatacagatc atcagaatgc 1981141 tctacattaa ttgttgaaag aatttcgatt ttactttcca ttttttcatc ctccagtttg 1981201 aacaaatatt gttagtcata ctccatttca ggacacgcca tactagtatc acagagcggg 1981261 aaatccgctt ttaaataaaa caccatccta ctcccacacc gcaaaagccg ctttatgcgg 1981321 cttttattct ttttcccctg caacataagc ttcaagctcg ctgtcagtca tttcggatac 1981381 tgaggttgtc ggcaaggcat caagaaacag ccggccgtaa ccagcggttt taatccgtct 1981441 gtccaatata ataatcgttc ccttgtctcc cgcagaacgc agcaagcgtc cgattccttg 1981501 cctgaaggtc agcacagctt ccggtaatga cactgtttga aacggattct ttcctttttt 1981561 gcgggcaagc tcacattttg cagcatgaag cgggtgatca ggggaccgga atgggagcct 1981621 cacgatcatt actgtcgtca gctcatcacc agggaaatca acgccttccc aaaaatgatt 1981681 tgttccgagc aggatcgcct gattggatgt tttaaaagtc ttcatcagtt tgccgggact 1981741 tccgcctgta atcccttgtg ccaagagctg aatgccggaa gcactcatgt tatgcttaag 1981801 ctcctggtga acctttttca gcatatcatg ggatgtaaac agcacaagga ttttaggctg 1981861 tttttccttt gccatcagtt cgatataacg ggctgtatcc tgtataaatt caggttgccc 1981921 tgtatcctga attgatttca tttcttttgg aatcatcacc tgcatacgct catcgtaaga 1981981 aaagggtgac tcaattctca ttgtccgcgg gaaaaagtca ctcagtccca gtcgttcaat 1982041 cataaattga aaagaacctt cgactgtaag agttgcagat gtcagcacca cactattttt 1982101 gcgcgcgaaa aactgatcag ccagaagttc accaggttca agaggctgtg cgtaaatggc 1982161 cactgcattt ttcgcaccct ttgcatctat ttcaatccaa accgcttcat cgtcatcaga 1982221 gccaaagaag agcttctgca acgtctgaca gtaatgctgc aagcctttca tgcttctttg 1982281 gtattcatcg gctaaaaaga cggttttgct cttcatgccc ttcaaatgtt tttccataag 1982341 ggatgactgc gcctcaaaaa gctgctgcaa atgtgtcagc atggaacaaa gcctctccgc 1982401 accatctgtt aagatcgacc agcttttatc ctggctttct ttgttcacct taaacactag 1982461 acggtttaag tcttctttag gttttcttcg tttgacaaaa gaatgtacag agctaaagaa 1982521 agcatcactt tctgcttgaa cgtgctgaag ccactcttcc aattcgaaaa atgaatcaac 1982581 cggcaggctg tttcgctgga atagctgtct catctttttt agaagtccct gctccttcag 1982641 agtgccgatt ctgctcaatt tcgtatgcaa ttctatgtac gtggctcttt tccctaaatg 1982701 ttcgcttgcc gcacgttcaa aatggtgtgc ttcatcaata ataaatgtgc cgctttcggg 1982761 aagccttttt ttatggctgc cttcatcggt cagcaaaaga gaatgattgg tgatcaccaa 1982821 atcggaacgc atagcaatct gtttggcccg ctcgtaaaaa ccgatcacat gctcactgcg 1982881 acttctttta taggagtcat cgtcataagc caatctgtcc cacagcaatt ttccgcctga 1982941 aggcaaattc agttccgcta catctcctgt atttgtctct gtcagccaaa caagaagctg 1983001 tgcctttgtc agtacggcat cataattatc atcttcttca tgaagcacct gctcaaattt 1983061 atacaggcat aaataatgcg attgcccttt taaaatcgcc gctgttaccg gaaatggaaa 1983121 cagatcttgg acaatcggca aatcctttgt gagaatctgc tgctgtaaaa gcgtcgaata 1983181 cgtgctgatt atgaccggct tttttgattt cttggcaaaa agcgcagccg gaataagata 1983241 gccaatcgtt tttccgatgc ctggaggagc ttcaatcagc gcatgctcac gattggcaaa 1983301 cgcatcagcc acctctctca tcatcatcat ttggccgtct cttttttcat acccaggcat 1983361 taactctgac agcgcttttt catttcccgc ttcccagctt tcgatctcaa atgagaagtt 1983421 ctcgtcctca tttatacgaa catcgatagc ttcaggttct ctgacagaaa acgaagaaaa 1983481 gcgcgtatag cccggtatct cggtatgtct gttttcatta atgaacatat ccaacaaatg 1983541 cgtcagatca ctgatgaaat gctgcgaaag ccttcttaac tgctttaatg tcggataagg 1983601 aagctgccgc agcttttcaa ggatttccaa aaaaataagc cctgtcactt cagcatcgct 1983661 gtcagcccgg tgcggctgat catgccgcag ctgaagctcc tcgcttaatt ccgtcagctt 1983721 atacccttca aatcccggaa aaacaatgcg tgagagctcg acagtatcaa gcacttcaca 1983781 atctgggagc tgaaagcccg ccttatgtag ctcatacttg acaaatccaa ggtcaaaatg 1983841 gatattgtgg gcgacaaaat aagcgccgtc aagcaattgg aatacttctt cagcaactgc 1983901 ttcaaatggc tgttcattct cgaccatttg attagagatt ccagtaagct gctcaataaa 1983961 agcagggatt gatttatttg gattaatgta ttttgaaaac cgctcagtaa tttgtccatt 1984021 ttcgattaca accgctgcga tttgtatgat tttatcgcct ttcttcggcg aattccctgt 1984081 tgtctctaca tctataacaa cgaaccgttg cttattcatt aaaatggaca cctcaattct 1984141 tgcatacgac aaaagtgtaa cacgttttgt acggaaatgg agcggcaaaa ccgttttact 1984201 ctcaaaatct taaaagaaaa cccccgataa agggggcttt tcttctacaa aattgtacgg 1984261 gctggttcgt tccccagcat ttgttcaatt ttgttttgat cattcagaac agccactttc 1984321 ggctcatggc ttgccgcttc ttgatcagac atcattttgt aggaaataat aatgacctta 1984381 tctccttcct gcacaaggcg tgcggctgca ccgtttaagc atatgacgcc gcttccccgt 1984441 ttaccaggaa taatatacgt ttcaagacgt gctccattat tattattcac aatttgtact 1984501 ttttcattag gaagcattcc cacagcatca atgagatctt catcaattgt aatgcttccc 1984561 acatagttca ggtttgcttc cgtaacagtt gccctgtgaa gtttgccgct catcattgtt 1984621 cgatacatat tatattctct ccatttctcg aatatcaata atgatattat ctattaaacg 1984681 cgcttttgaa aaagcaactg caacagcgag aatcatcttt ccagcaattt cattcacagg 1984741 ctcgagttcc ggataggaat aaagctctac atagtctatg gttccgctag tcgtttcaat 1984801 gatatctttt gcagctttta tcaccgcttc aggatctctt tcaccggctt ggacaagttc 1984861 cgcacttgtt tgaagggccc gatacagctt aggcgcttct tttctttcct cagctgttaa 1984921 gtatacattg cgagagcttt tggctaagcc gtcttcctct ctgaccgtat cgacaggaac 1984981 caattcaata tccatgaaga agtcgctgat taacccatca acaacagcta cctgctgcgc 1985041 atcttttaaa ccgaaatagg cacgagtcgg cttgactaga ttgaaaagct tcgtcagtac 1985101 gatcgcgacc ccgtcaaaat gtccttctct tgagcgcccg cataacacgt ctgtgcgtct 1985161 ttctacatga atcgtgacat tcttttcacc gggatacata tcatgagcat ctggcgtaaa 1985221 aagaatatcg actccggcgt tttctgcaag agctgcatcc cgctcaatat cgcgcggata 1985281 tgcttcaaaa tcttcattag ggccgaattg tgcaggattc acaaaaatac tcataataac 1985341 ggcgtcgttt tcttgtcttg ctttgtctgc taaggttaaa tgcccctcat gcagaaaccc 1985401 catcgtcgga acaaatccga ttgacttgcc ctctgaatgg tattgtttta tggcttcttt 1985461 cagctgtgaa atatcagtaa tctgtctcat cttattttcc cccgtacaag ccgtcaagca 1985521 ctgtctggtt catttgaaag gaatgctttt gttcagggaa agcacgatgt cttacatcct 1985581 gaacatatcc gctgattgct gtttcgatgg tttcatcaat gcgcgtatat tgctttacaa 1985641 atttaggtgt tctctcaaca ccgtggccga taatatcatg ataaacgaga acttgtccgt 1985701 ccgctttcac accagccccg attccaatga ccggtatgct tagcgtctcg gcaattttgg 1985761 ctgtgagttc tgccggcaca cattccagca caagcatcat agctcctgct tcttcgcatt 1985821 ttatactgtc ttctattaat tttttggcgc tttgttcgtc tttgccctgt actttatagc 1985881 cgcccagtac gccgactgac tgcggtgtca aacctaagtg actgactact ggaatgcctc 1985941 caagcgtcaa tgcgcgaatg gattcaaaca cgccttctcc gccctcaagc ttcagtgcgt 1986001 cagctccgct ttcctgaacg atagccgctg catttttcag cgtatcttcc ttagacaggt 1986061 gataagacat aaacggcata tctgtcacaa taaaggtatt cggcgcaccc cttttaacgg 1986121 cttttgtatg atggatcatg tccgcaactg tcacaccgac agttgaatca aggccgagga 1986181 cgaccattcc aagtgaatca ccgactaaaa tcatgtcaac tcccgcttgt tcagcaagtt 1986241 tagctgccgg ataatcataa gcggtcagca tgacaatcgg ttcttcagac tccttcattt 1986301 ttagaaaatc cagttttgtt ttcatgtttt ctcctcctca tgtttagagg agatgatctg 1986361 ccgttttctt ctgcaagcca aaaaaccttc cgttacaacg agaaggattc ttcactttct 1986421 aaagttcggc gagtttcatc cctctgtccc agtccttttt tggatcaagg cagactgctg 1986481 caatgtctat ctattttaat aataggtgca gttcgcaggc gatactgccc aatggaagta 1986541 taccaaaatc aacgggcttg taccaacaca ttagcccaat tcgatatcgg cagaatagat 1986601 ttttttaatg ccttcgttcg tttctaaaag cagaacgcct tcatcatcta tacctaacgc 1986661 cttaccgtaa aaggttccgt ttaacgttct ggctctcata ttagtgccaa taccgagcgc 1986721 atagctttcc cataaaagct taatcggcgt aaatccgtgc gtcatataat cccggtaccg 1986781 tttctcaaag catagtaaaa tatgctggat gacgccggcc cgatcaattt tttccccagc 1986841 agcttggctg aggcttgtcg cgatgtcctt caattcatct ggaaaatcat taggctgctg 1986901 gttaacgtta atgccgatcc caatgatcac tgaacgtacg cggtcttctt cagcctgcat 1986961 ttccgttagg ataccgactg ttttttttcc gttaatcaaa atatcatttg gccatttaat 1987021 atccgtttgg atgcctgctg cctcttctat tccctgcaca acagctactg cagcaagcag 1987081 agtcagctgc ggtgtttttt ggagcggaat gtcaggccgc aaaatcaggc tcatccaaac 1987141 accgtttcct tcttgagaat gccataccct agacattcgg ccccttccgg ctgtttgttt 1987201 gtcagccacc acaagggtgc cttccggtgc gttattattc gcgagctcat gagccgtttt 1987261 ttgcgtgctt gaaagaacgt catggtaaat aagatgctgg cccatcactt ccgtttttaa 1987321 tccaaaacga atttcgcttt cactgagttt tccgggtttt ttgatgagcc gatatccttt 1987381 tcttctaacg gcttctactt cataaccctc tttccgaagc tcttcaatat gcttccacac 1987441 agcagttctt gaacagccga gagcatcact gattttttgg ccggaaataa attcattgcc 1987501 ggcctgagaa aataattcaa taaggtcttt tcttaatgtt gaccgcatgt cttcagccac 1987561 tcctctatgt gtttcttttg attggagagc ttccctgtca caacagcctg ctcgatccac 1987621 tgtaattctt ctgacaccca ttttccggcc ggccggtttc gaagcgcaag caagtcctta 1987681 cccgtgatat caagatcctt aaggcttttg atcggcaggt tttgataagc gtactgaatg 1987741 tccttcagtt tcttttcatc cagtttttcg ttttgccgaa gctgcgatat tttggccgct 1987801 gagagcagtg cttttttccc agctctgtac attgtcattg cgtcaaggct ctggccaaac 1987861 gtatcggcaa tgtgaatggc ttccttgatc acttttcccg ggagcttcca ggctttcagg 1987921 aaaaggggcg cgtctttcaa aactatgcca aggttaatta aaagagcagc ccaaagctcc 1987981 tcacgggatg ttaaagagaa gaatggaaac tcactcgttg aaatcaggtt ttctcgttta 1988041 tgataaaaac caggaagctc ttcatacaat ctcgtttgaa tgagtgtttg aagcgcctgg 1988101 cgagaagctc ttccctgcag caatttctca aactctatag tttttcgttc gactgaaaca 1988161 tgggagagga gtgatttttc tttcgcaatg gcttcttctg tttccggtga aagcgtaaag 1988221 ccaagctggc tcataaagcg tacggctctc agcatacgaa gcgcatcctc ttgaaatcta 1988281 tcctcaggct ttccaacggt tcgaatcact ttctgatcaa tatctttctt gccgccaaaa 1988341 taatcaagca ccttcccgtc cgctgtcatg gccatcgcat tgatcgttaa atctctgcgt 1988401 tttagatcct cttctaatga tgagataaat tgcacttctg acggtcttct gaaatcaaca 1988461 taatcagatt cagtccggaa tgtcgtgact tcataggttt catcctccca gagcacaata 1988521 atggtcccgt gctctttgcc tacatcaaca gtccgctgaa acagccgttc tacttgatca 1988581 ggtgccgcat ctgtcgcgat atcgacatct ccgatcgttc gtttcatata gctgtcacga 1988641 actgcgcccc cgacaaaata agcctgatgg cccgcttcga ttaagatgcg gagcacggga 1988701 agtgctttga taaaaacttt ttccatgtga tcactccggt tctgctaaat cggcataaat 1988761 ctgttcatac tggctgacaa tttttttaga agaaaattca ttttcaagca tctctattgc 1988821 cgcctttgta aaacgattgc ttagctgttc atcttctaaa atgctcatcg cgcgggctgt 1988881 tgcggccgta acatcaccga catccaccaa aaatccgctc acattgtttt ttataacctc 1988941 agggataccg ccaatgtttg ttccaataca aggcactccg caagccatcg cttcaagcag 1989001 gacaaggcca aagctttctt tttcagatag cagcagcttc aaatcgctaa tagaataaag 1989061 atcttcaaca cggtcttgat ttccaagcat taagacttgg tcttccaagc catattttct 1989121 gataagctcg caggctgtcg atttctccgg accgtctccg actaaaagca gcttcgcttt 1989181 cgttttgcca gcgatattgc ggaacacacg gatgacatcc tgcacgcgtt taacttttct 1989241 gaagttggac acatggatga cgactttttc atctggtaaa attccatgtt tctctttaat 1989301 tgccgctgtg tttttcttca gatacacgcg ctcgtctata aagttataaa tcgtttcaat 1989361 ttttttctcc ggtttaatta aatcgtatgt ttcagccgca agcgctgagg agacggccgt 1989421 caccctgtct gatgactcaa tagcaaaacg gatcagatct tttagagacg gatcataacc 1989481 taacaccgtg atatccgtgc catgcaaagt ggtaacaatg ccgatattgc gtttcagcat 1989541 ttgttttgca agataggcgc aaacggcatg cgggagagca tagtgagcat ggataatgtc 1989601 taaattctcc cgttccgcca cctcagcgat tttgcttgcc aatgtcaaat catacggagg 1989661 atacttaaaa acagcatatt gattaacctc aacttcatga aaatgaatat tgggatgata 1989721 tgtattcagt ctaaacggaa tgcttgatgt gatgaaatgg atttcatgtc ccttttcagc 1989781 aagctgcttc cccagttctg tcgcaatgat acctgagcct ccaacgctcg gatagcatgt 1989841 gattcctatt tttagttttc tcattgttcg cccccaagca catcatgatc aagcatcagc 1989901 atccgtttgg aaaagaaacc ttcggcatac tccacgcccg cttctttacc gtaaagcttt 1989961 tctctcgctt caacgatttc aatataccca ttcgtcagag gagtagaaac ggaatccttt 1990021 gacgggataa actggctttt gtaggcgttg aggctttgtt tctttgcctc tattgtatcc 1990081 gagatatcaa taacaaaatc cggctgatga aaaccattta tcatataata gtaaaccttg 1990141 ctgactttat gcgccggaag gcttttttcg tctttatatt tatggattcc ggcggaaaag 1990201 atcgcttctt ccaccagtgc agccgcattg ccgtgatccg gatggcgatc ctttttatac 1990261 ggcataaaaa ccgcttttgg ccgacagatt ctgatgacag tgacaattga ccgaattgcc 1990321 tgatcactca ttattaggcc gcggtctgga agcgttagct gaattctttt atctgcgcct 1990381 aatatgcggg ctgcttcagc tgcttcttct ttacgcaaac tgaccgtacc gttagaagag 1990441 agttccgctt ctgtcaaatc gcatatcatt actttttttt cctgtttgac aaacttcgct 1990501 attgtgccgc ccattccgat ctcgacatca tcactgtggg cgccaaaagc aagaacgtca 1990561 gcattataca ttcggctctt ctccccgaag aaggtcacgg aattcgaaaa caccttcatc 1990621 aagtgtgcgc acaagaattt ccgcagtacc catatttgtg gcgagcggaa tggaatacac 1990681 atcacataaa cggattaatg ccgagacatc cggttcatgc ggctgcgcgg tcagcgggtc 1990741 gcgcaaaaaa atgacaagat cgagtgcatt ggcagcgatc agtgcaccga tttgctggtc 1990801 tccccctaaa gggccggatt gaaaacgttc aatttgaaga cctgtcgcct catgaatttt 1990861 caaccctgtg gttccggttg cgtatagatc atgattcttt aaaatatccc gataggcagt 1990921 cgtaaattga accatatcct gttttttctt gtcatgcgcg atcaaagcaa ttttcattgt 1990981 ttatcccccc gtctaatcaa tgatattttc taaaccatac acaagctgat caatcttcat 1991041 gacttgttcg actgacagtt taacgcctga catgaaagaa gcacggttat aagaatcatg 1991101 gcgtatctga agcgtttggc catccatgcc gaacatgacc tcctgatgcg cgatcagtcc 1991161 cggaagacgg acgctgtgca agcgaatacc gttttgctcc gctcctcttg ctcctgggag 1991221 aatttctttt tcatccggat gtccttgctg cttttcttta cggacttctg aaatcatttc 1991281 cgctgtttta agcgcagttc cgcttggtgc gtcaagcttc tggtcatgat gaagctcaat 1991341 aatctcaaca tcctcaaaat agttggcagc catttttgaa aatttcatca tcagtatcgc 1991401 accgagcgca aaatttggcg cgatgatggc tccgatccct ttttcttctg ttaaagatgt 1991461 gagctctttt aaatcagctt ctgagaaacc ggttgttccg acaactggac ggactccgtg 1991521 ctctaatgca atttttgtat gtacttttcc gatttcgggc gttgttaaat caatcaagac 1991581 atccggttgt gtttctgtaa aacaggcatg gatatctgtg taaatgaaag catctgactc 1991641 aacaggcatc acatcagata atttttgctg atcgtatgta tggtctatgg cccctacaag 1991701 gtcaaaatgt ggtgttcgtt ctgccaattt aacagcttcc tgccccattc ttccacgcgg 1991761 tcccgcaatg actaatttaa ttgtttcgtt tgacatcttg atctcctcta ctttccttct 1991821 tcttttctgg tccagcgatc tttatctctt gtattaaatt tatgcatgac tcggtcgtga 1991881 gcttcctcta aagagatatc aagagagttg gctaaacaaa ccaatacaaa tagcacatcg 1991941 cctatttcct cttccatgct tttatcatct tcagtcgctt tttttggttt ttctccataa 1992001 cggtgattca cttctctggc aagctcgccc agttcttcag tcagcctcgc catcatggcc 1992061 agcgggctaa aatatccttc tttaaattgg cctatgtaac ggtctacttc agcctgtatg 1992121 tctttcattg ttttatcact cactgaacga aacctcctat catcctctta catgttagct 1992181 aattcagata cgtttgacaa atgtttaagc acgtttgctg ttttcttttt catccactat 1992241 aatataaacg ctatctaatg gaaggaaaag gggttttgtg tgatgcttgg agaaattaga 1992301 ttaaaaaaca tattttttat tttaatcgga gcggcaattt tttcatttgg cttggttcat 1992361 ttcaatatgc agaacaatct ggctgagggc ggttttacag gtattacact tttgctttat 1992421 gcccttttcc acatcagccc ctctatatcg aacctggtgt tgaacattcc gatttttttt 1992481 attggctggc gtttgctcgg caggacaatg tttgtttata cccttgtcgg cactgtagcc 1992541 ttgtctttgt tcctcagcat ctttcagcga tatgaaatcc atatgcccct tcagcacgac 1992601 ttagcgctcg ccgctttatt tgccggcgta ttcatcggag ccggactggg tattattttt 1992661 aagttcggcg gtacgacagg cggtgttgat atcatcgcac gtttagtgaa taagtatttt 1992721 gggattccga tgggcagaac gatgtttgct ttcgatgcct gcgtcatcat tttgtctttg 1992781 cttacttatc tctcctataa agaagcgatg tatacgctgg tagctgtatt tgtagcggca 1992841 agattaatcg attttattca ggaaggcgga tacgctgcta aaggcgctac gatcatctct 1992901 tcgaaaaacg acctgattca gaaaaagatt cttgaagaaa tggaacgggg cgtcaccatt 1992961 ttgaaaggac aaggttccta cacaaaagag gatatagatg tactttattg tgtggtgccg 1993021 aaaaatgaat tggtgatgct gaaaagcgtg attaactcca ttgatcccca tgcctttgta 1993081 gcggtaagcg atgttcacga tgtgctcgga gaaggattta cgcttgatga aaataaaaat 1993141 ccgcttccgc gctgacatgt aatagaaaaa aggcggctga ccgccgcccc tcatccttat 1993201 ttagggtagt cccttttttt cagcttgttt ttttccgcct tgtactttct gtaaccgaca 1993261 taggtaagag cagtaatgat gatactgccg gttgtaatga tcacccagag taaagacgga 1993321 tcggcatcat cctcctccac cctgtcaaac acatttttca ggtcatgctg aagaagggaa 1993381 agccgttcaa gcttcgtgct ctctgtcatt tgctgaaatt cctcttgctc aataacatct 1993441 atatgttttc cgactgtttc aagctgatcc tctgatacat cgattgtaag actggggtaa 1993501 atcaagtcat ataaactgat aaattcattc catttttcat gaaagcttgt gcttccattc 1993561 ttttggacat ctcgcttcag ttcagtaaaa gcttccataa tcggtttttc cagtgagccc 1993621 caaagcgggt cagaccgatt gtcaaccgca tccatcagca ttctgaactg cgcggctgct 1993681 ctgagttttt gtgtgtctga tgtatcagct tgctttaaac tccgaaccat atcattatag 1993741 cccaatgtga tttgacgaat ttgggctccc gttagcatgg ggtcttgctg ttttttctca 1993801 gcggatttta atgttttttc aaaatactcc aagacttgaa gcgcctcttc atatttcgcc 1993861 tgtcgggtca tttgaaagac tgtatcggat aaatcattca attcctcgag gcttccccgc 1993921 tctgcagcct tggcatttcc attataaaaa ataagtgcaa tcaacaaaca gatcgtcagc 1993981 tttcgtttca tgcaggtccc tcccactctc tctccttaca gaatatgaag aaagggacaa 1994041 ggatagacca acattgtctt tacatcagct caagcttcgt ttgctttttt gagaccacaa 1994101 gaaagtaagc aagcgcgatt gaaaagatac ttagccaaaa tgttccgtat cctatttcag 1994161 tcatataatc agaaagcata gagtattgcg gcatcatatc aaacaagtag tcaatgacat 1994221 cgttatgcag tgtccagact gcagcaattg caagatgcca aaatgaaaaa cgaaaatacg 1994281 gactgtataa tacgccttga actgccattg caaaatgcga agcaattagc atgtagccct 1994341 cccacggcaa gtcaccagtt actgcaagca caagaaaatt catagccacc gcccataggc 1994401 catactttac gagggtaact agcgcaagcg cctctaaaag cggagcattc cgtttcatga 1994461 gaaaggcaag cagcacaaac agaaagaaaa acgttgctgt cggactgtcc ggaacaaaaa 1994521 tcaggaaacg ggccggtgtc tccaaaagct gcggcaagta ccaatagtag ccgtaaaccg 1994581 ttcccagaaa attaatggct aagacaagaa taagcatcgg ccgctgccct aatacatatt 1994641 gaaaccattt cacatcgaat caactctcag tctgtaaaaa taatatgtcc atataaaaaa 1994701 gctgacgccg ggtcagcttt tgataataaa agtatatcct tccatttgac aattcacaat 1994761 acgttatttt gcggttgttt cagaaataaa ttttgcaagt tcttcgagct gcttatcatt 1994821 tcctttgaac acacccgccg gcattttgcc tttcccttct acagcgattt ttttgatttc 1994881 atccggtttc agcccgctgt caaccaatga aggcccggcc gctcctccct gaaggttatc 1994941 cccatggcaa gaaatacagc cctgttcctt aaaaacctta tatccttctg cattggtgtc 1995001 aatgtcggct tcttttgtaa ttttcccctg ttcttctgcc ttggcccagt catgagtagc 1995061 aactgactgc cacgtcaaaa atacagcagc ggaaatggcc agaagcatca taccgacagc 1995121 gaccggacgc ttccacggcc ttctttctgt ccctctgtct aggaatggag ccaaaagcag 1995181 ggccccaaaa gcgagacctg gcataatcat ggcgccgacc actgtaaagc ttccggcggc 1995241 gtattcatac ttcaacagct ggtataagaa aagaaaatac caatccggca gcggaatata 1995301 accagtatca gtcgggtccg ccatccgctc taaaggcggc tgatgcacaa tcgtcaaaac 1995361 gagaaaaccg atgagaaaga cagctccaac catccattcc tttaacaaga aatttggcca 1995421 gaaagcctct gttttacccg gatactccga ataatccttc ggtatattcg gctttttttc 1995481 agccggtatc cttgagtcgc ctacaaattt catccctttg ccccggtgca tgtcatcccc 1995541 tcccttttat tcgcagatca agagtttaaa gcggtcctga aatcccctgc ttccggatca 1995601 taataaaatg tgcagccatc agcccgaaca atgcggcagg aagaaaaaat acatggatcg 1995661 caaaaaacct agtcagcgtt tgggcgccta caatatccgg atgccctgca aggagcgttt 1995721 taacttgcgt tccgatcaaa ggcgtggctt cggcgatctg cagtccgact tttgttgcaa 1995781 acagagcctt catatcccaa ggaagcaagt agcctgtaaa gccaagaccg agcataacaa 1995841 aaaagatcag cacaccgaca atccagttca gctcgcgcgg ttttttatac gcgccttgga 1995901 aaaagaccct cagcgtatgt aaaaacatca tcacaatgac caggctcgca ccccagtggt 1995961 gcatccccct gacaatctgg ccgaatgcca cttcattttg caaataatat accgattccc 1996021 aggcattttt gatatcaggc acataataca tcgttaaaaa cattccagat aatacttgga 1996081 taacggttac aaaaaacgtc agtcccccaa agcaatacac aaacgcagag aaatgatggg 1996141 cgggattcac atgttccggt acttcgtgat cggcaatatc cctccacatc ggtgtaatat 1996201 caagccgctc gtctacccag tcataaattt tgttcagcat gtcacccttc ccccttaggc 1996261 tttgcttttc caagatacag gaagccgtct tttacttctt gctcataatg atcaagaggc 1996321 gcaagcggcg gcgtgccagg gacattggtg ccgtcctttt catagagtcc gtaatggcat 1996381 ggacaaaaga atttattcgg gtttttagga tcactattcc agttcaccgt acaccctaaa 1996441 tgcttacaaa ttggcgaaag tgctacaatt tcatccccgt ttttgaagac ccaggctgat 1996501 cttgactctt ctgactcata ccaggcatcg acttgattaa ttttaaaatc aaagcgctgc 1996561 ggctcttttg tcaactcatc aacgctgaca acctgaacca tatcctgctt ccctgtcgat 1996621 tttaataccg ggtcgagtgc gaagcgaacc ataggcatga gcatactagc cgccataaaa 1996681 cctcctacgc ctgtgagcgt ataattcaaa aattgacgtc tggatatatc atgttttccg 1996741 cccatctctt ctcccccctc taagtcaccc ctgcaaactg actaaaatag aaaatattgc 1996801 aataactcta gacaccctca taatatatga atctctcagc aaggtcaata tagccaaaat 1996861 attgtttata aggaaatgta agtgttttta taaagtgctc cataactgta acaaaacgtt 1996921 caaaatttca gcagtgcgtt catccaatat ttttcttttt aaagagtcat ttaaatgctc 1996981 taatggaaca gacgatgtaa caatcatttt gcctaacgca tcctcagctc tccaactttc 1997041 gtcagatgtg agcaggacaa catgcggaaa ttccgttatc agctcttccc gcaaatcctt 1997101 aagcccttga acggttattt catttctatc aacatatgta taaggcggaa gtaaatatac 1997161 ccgtcccttt aactgccttt caagttcttc tgagagaagc tgcgtaaact cgcctttctc 1997221 cgccgccatt ttaaaatggt tattaaccct tatgttaatt aatggtatga cagcggtatc 1997281 aatgtaatcc ttagcttgta aatagtcctt ggcatcagtg attctccacc tcatcgttct 1997341 ccccctttac ggcaacaagc cttgcaattc actgcaaggc tggtcatatt atgtgagctg 1997401 atttaattgg cgcgataatt gttcaaatgc ctctttatca tgacgatcta acgcgtcgtc 1997461 aatgtctttt aataattttt ctctttggaa tgtggaaata gcgtgctcta aaatctgttc 1997521 cgccaatccc tgatcttttt tattctcaaa aaggtttttc ggaatatgcg ggttggactc 1997581 cagcaccgcc gcatattcag gtgagctgta agccgaacgg aaattaagct ggataaacaa 1997641 atcctgctgt ttatttaatc taatatcatg aaaagatttt tccgcgtcgg tagtcatgac 1997701 attctcttta tagaaccgga acggaacttc ttcaacacaa tgtgttgaca ttataatgcc 1997761 tctcgggcaa aattcagcct gctccacaaa atgaaccttc tccatgagag aatcatggct 1997821 cattaagtag ttcaagatcc aaacgcactc tcggcgcttt aactgataat ggtttaaaaa 1997881 ccaacggata aaatcttttt tctcattgac agaaacaggg gtctgcatgt aattccctcc 1997941 tctatcgttc gtataatcta tatacttata tgttccacat gaatggttaa tattcctgct 1998001 tatctagaaa attcatcctc gattcgcaaa atcgtttctt caagctcttc attggctccg 1998061 tccatttcaa gaaccttttt caaaagcggc agcgcttctt tttgaagacc ttcttctaat 1998121 aggaagcttg cgtattcata taagaaatct ctatcctccc ggtaatgaag ataggcagcc 1998181 tcaaaggatt gttttgcttc ctcgtattgc tctaattcag tatatgcgct tgcaagatac 1998241 caattgtatt taggatcttc ttcaccgtag cttcgaacct cttgaataag atcaatgatc 1998301 tgatcataat cctcttcttt gtgatacacg gcaagaagtg tatgaagcgc ctcgacaaag 1998361 cccggatcaa gcgcaagcgc ctcctgaagc agcttcttcc cctcttctga cttcccgatt 1998421 ttcaaggcca ttttggcggc ataaaggaaa agttctttgt tatattcatc atatctgatc 1998481 ccctcttttg ccgtttttaa tgcctcttca tacattcctt cagcttcata gcttttcgag 1998541 agcggcatat aaagtgaagt ataagatgga tcaagctcct ttaaatcaga cagctgctta 1998601 atagctgttt tcacaagccc cgcctgtaag gctgtaaaac catagccgaa aatcgtatta 1998661 ggatcaggat tctcatcgac agctttctca taccatggaa tggcatcctc aaattcacct 1998721 gaggcactta acgattctgc cagtctttga tggacattaa cgcccccgat ctcactctgc 1998781 tcctcagccg ttgttttaaa atattgaacc gcttttgcat aggctccctg agcaaagtaa 1998841 agttctccca gtgcaaaatc aataacaggt tcattgtcca gaatggactt tgcctggaaa 1998901 agcttttgtt cactgacttc gaataacccc tgcatctgat aaagatccgc cataagcagc 1998961 aaactttccg gatatgatgg atctgtttcc ggaatagtct ccagcacagc gagggctttt 1999021 tcttcttcgt caatatctat taaaagttca gcgtagaaat tcgtcagttc tgtttcattt 1999081 ggatataaat catgtagatc actaatcagt gaaatggctt tttctacatc gccccactcg 1999141 taataaagct gggctgcaat ggctttatct tcatcatgca gctgtttttc agccttcgag 1999201 agcgtgttga ggcctttttc tgtttcacct gcttcaacta attttatggc ttcttgaatc 1999261 aatgtattca aatcggaccg gtcctttctt ttcctataca acatcaacca tacaaaaaaa 1999321 gctttatttg ttcgggttaa tcttatcata attcagacga atgcccccgg caaataagat 1999381 gcttctgtac ggaagggaat tattgagtct tattagttta ccaaaagatc ttgagataga 1999441 aaatgaaaaa aggaagatcg ccctctgtac agtaaagcag ctctttgacc tgccggcttg 1999501 taagtaaagc acatcccccc ttttcgtttt tctatccgtt ctataagaca agctatgttt 1999561 tttcgcctcg aattatgatc tgcataaaaa atcctgaagt aaaacttcag gattttttcg 1999621 aaagcttatt taaatgctcg aagaaggttg gataagaaac gtgaatggca tccgtgtgct 1999681 cgatttcaat cggctcctcc gttatacagg aagcaatacc aagcatcatt ccgattcgat 1999741 gatctccgtg gctggacact gcagcgccgc ctttcaacgt ttgtttgcca taaaccttca 1999801 ttccatctgc tgtcggttca atttcagcac ccagcttgcg aagctcagaa acaacagtat 1999861 caatacggtt tgtttctttc acttttagct ctgccgcgtc cttaataacg gtggttcctt 1999921 ccgcctgagt cgcaagaagc gcgatgatag ggatctcatc aattaaacgc ggaatgatat 1999981 ctcctccgat ttcaactgcc tttagagatg acgtttctat aatcaaatct ccataaggct 2000041 ctgcaccgct atcagcagat ggtttgattt caagttttgc ccccatgttt tgaaggacat 2000101 caataatacc tgtccgagtc ggatttaaac ctacgttttt caatacaatt ctgctgtttg 2000161 gaaccatcgc gccagcagca aggaaaaacg cggctgaaga aatgtctcca ggaacaaaaa 2000221 tatcagcagc tgtcagtttc tggccaccag caatggaaac actcgtttga tcttcagaaa 2000281 gcttaacgcc aaaagcagaa agcatccgct cagtgtggtc ccgagattta tggggctctg 2000341 ttacagttgt tgtgccctca gcctgtaatc cggccagcaa aacagcagat ttaatttgcg 2000401 cgcttgcaac aggtgataca taatcaattc cttttaatga agcgccgctc actgacagcg 2000461 gtgtaaactc tccgccggct ctgccgtcga ttttagcccc catttttttc aaaggctcag 2000521 tcacacgctt cattgggcgt ttcgcaatgc tctcatctcc ggctaccgcg ctgtaaaaag 2000581 gacggcccgc caatattccg agcatcaggc gaatcgttgt acctgaattt ccgacatcta 2000641 aaaggctttc tggctctttc agggcatcga ttccttttcc gtgaatcacg acatcgctgc 2000701 tgctttgctc aatgtgaaca cccatttttc taaagcaatc gatcgtgctc agacaatctg 2000761 ctcccggcag aaagttttta actgttgttg tgcctgccgc tagcgcgcca aacataacag 2000821 agcggtgaga aatggattta tcaccgggaa tatgtatttc tccatgtaag gtctgcacct 2000881 tatctcgttt cattttttcc acctcaatca gcataaaaag tttcatattc cgcccgggct 2000941 tcaatgcatt gttctgccct tttgcggtcg tcatcagact gaaaactgat ccttaaaatc 2001001 ccgttaatat cctctcgtgt ttcgataatg cggatattcg tgatactgat gcgctccgca 2001061 gctaagatcg ctgttatctc ggatattaca cccggatgat cgggtacatc cacatataaa 2001121 tcataaaatg caggtatcgc tcccttctgc cgaagcggca gcccgtcgcg ataatccttg 2001181 gctgttttaa aataacgaaa tagattttcc gcatcttctt gttctacata tgtacggatc 2001241 ttgtcaattt cacgaatcca ctcatcaaaa cggtctaaga ttttatcttt attatgtaat 2001301 aaaatatccc gccacattgc cgggctgctt gatgcaatcc ttgtaatatc tctgaacccg 2001361 ccggcagcaa aacgcttaac aagcggatac aggttttccg aatgatgggt ttggtgaaca 2001421 aggctagctg ctacaatatg cggaaaatga ctgattacgc ttgtaacgcc atcatgctcc 2001481 tctggcgaca tttccacaaa atgggcattc gtccccttca gcaggttttt taactgttcc 2001541 acagcttgtt tgtccgtttt ctggcctggc gttaaaatat aaaatgcatt ttcaaacagg 2001601 aactccttcg cagcggccac tcctgattta tgtgaacccg ccatcggatg ccctccgaca 2001661 aattgatagc ggctaggcag cacttgatca gcgtaatcaa ccactttttg ctttgtgctt 2001721 cctacatccg taatcaaaag ctcatgttca attcctgaat gagccagctc ttcaagcata 2001781 accagtgttt gttcaacagg tgtcgcaatg attactgtag ctgcctcttt cacaccgcta 2001841 ataaacgaat cagcacgatc gtctatcacg cctaatttta atgccgctac cgcctgttca 2001901 tcagagatgt cgattccgat aatccgtttg ccgggatgat tttttttgat ggctagggca 2001961 atcgaaccgc ctatcaatcc gagaccggcg agcaatattg tatctttcat ttgattcata 2002021 cgtcatcacc tggtttatag actaaagagg tgatatttga tcacctctta taaaatttca 2002081 gctaaaatgg caagtatttc ttcattttgc tcttttgttc cgatcgtaat ccggagtgat 2002141 gtcgggaaac ctaatgcgtt tcctgaccgg acgatatagc ctttttccag cagagcctga 2002201 aacagttcat cagcaggacg tttaaagtca attaacacaa aatttgtctg tgaagggtag 2002261 cactttaaac catgagtttt cgcaaaatca taatactgct gaaggcctgc attattttgc 2002321 tcgacacagg aagcaataaa cgcttgatca tcaagtgctg caatcgccgc agcctggccc 2002381 agacggctgg tattaaacgg ctctctcgcc ggctcaatct ggcgaatcag gttctcgtca 2002441 gcaattccgt atccgactct gagcgctgcc agaccgtatg cctttgaaaa tgtgcgcaaa 2002501 atcatcaaat tggaatactt gcttaagagc ggcacggttt ccgggtaatc ctctgctgtt 2002561 acatattcat aatatgcttc gtcaagaacg acaaggacac gagaaggaac gcgctccaga 2002621 aatgcgagta attctccttc agatgtataa gtgccagtcg gattattcgg gctgcatatc 2002681 caaacgactt gtgtctgttc gtcgatggct tctaacatgg cgtctaaatc atgtgagccg 2002741 tcgggacgaa gtgcaatttc acgtacttca gcaccttcaa taaccgcatt atgtttatat 2002801 tgcggaaaag tgggggcagc agtaaccgtg tttgttttat cgtttaaaaa tgcccggcag 2002861 atgatctgta tgatttcatc agaaccgttg ccgaaaataa gtgatgtttc gctgacattg 2002921 aggtgcttac tgagccttgt ccgcaaagcg gcgctatacc cgtccgggta aagggctagc 2002981 tgttgaatct catgatgaag cgcctctttt gcagcctctg aacagccgta aggattctcg 2003041 tttgaagcaa gcttcacaac tttatccaag ccatattctg atttcactgc ttcaatcggc 2003101 tttccaggct gataaggctt cagctgtttt aaatgttctt tgatacgcaa atcagtcacc 2003161 tcattttaaa ctgtacaagc cgctaaacgc cattgcataa tcctcaaact cctgcagcgc 2003221 ctgatttctc gtttcagcgc tgatgagccg gtcctttaat tcttctattt ttctgacgag 2003281 cgcacttccc actacgacac cgtcactaat ttcattcatc tttatgacct gttcacggtt 2003341 tgatataccg aaccctacag caaccggaac agtgctgaga ttcttcacag tacgaatgaa 2003401 cgggtacacg gatgaattga actcattgcg gacaccggtc acacccagag aagatacaca 2003461 gtagacgaac ccctcggctt gttcaataat ggttttcaaa cggctttcgc ttgtcggcgc 2003521 aactaaagaa atatacgtca cctcatggct tttacattcc tcttgaaggc tgttgctttc 2003581 ttctaatggc agatccggaa caagcagacc gtcaatatga ttttcccgca gtaaagcgaa 2003641 aaagtattct ttgttcaatt gtaacacagg attataatac gtaaagagga taatcggaat 2003701 attcactccg ttttttttca tttctccgcc taattcgatt gcctttacga tattcattcc 2003761 ttgatcaagc gcccgctttg aagcccgctg gatcaccgga ccgtctgcaa gcgggtcaga 2003821 gtatgcaaca ccaagctcca atgctgtggc gcctgctttt tggagtgact tcgccagttc 2003881 aatcgaaacc tcaggaactg gatcgcccgc cgtaataaac gggataaaca atttttctga 2003941 tggttgaaga tccaatttaa acatgggctt tcacctcttc ttccaataca ttcattaatg 2004001 tgttgacatc cttgtctccc cggcctgata aacagacgag aatgagttga ccgcgatcca 2004061 ttcctttggc gagtttgaat gctttcgcta acgcatgggc agattcgatt gccggcaaaa 2004121 tcccctcttt ttctgacaaa agctttaatg catccaccgc ttcttcatcg gttatactgt 2004181 cataagtgac acggccgctt ttatgcaaat atgcatgctc cggaccgatt ccaggatagt 2004241 cgagaccggc tgaaatagag tagggctcaa taatttgccc gaactcatcc tgaatgagat 2004301 aagtcaatga accgtgaata acccctacgg ttcctttcga aatagtggcg gcatgaagag 2004361 gtgtatcaat tccttttcct gctgcttcag cgccgatcag ttcaacatct tcatttaaaa 2004421 atgcctgaaa catacccatc gcattgcttc ctccgcctac acatgccact actttatcag 2004481 gcatagtgcc ttcaatacgt ttcaactgat ccttcgcttc ctctccgatc attttttgaa 2004541 attcacggac cacttgcgga taaggatgcg ggccgacaac tgatccaatc atataaaagt 2004601 gatcctcaca atgctgaacc cagtaccgga tcgcctcatt tgtggcatcc ttcaatgttc 2004661 cgtttccgct tgttacaggc actacctccg ctccaagaag cttcatgcgg aaaacgttca 2004721 gagactggcg ggcaacatcc tcttcaccca taaacacagt acaggaaaag ccgaatttgg 2004781 ctgcaactgt tgcagcggca acaccatgct ggccggcacc ggtttcagca atgattttcg 2004841 ttttgcccat ttttttagca agcagcgctt gacctagcgc attattgatt ttatgagaac 2004901 ctgtatggtt taaatcttct cgtttcaaat agattttcgc gccgcctaag tattcagtga 2004961 ctcgatcagc gtatgttaat gcagtcgggc gtccggaata gtcctttaac agcttataat 2005021 actcttcacg aaaagcggga tcatccttga tttgtttaaa tgctgtttgt atttcatcta 2005081 acggctgcat gagtgtttcc ggaacaaact ttccgccaaa atcaccgtat ctgcctattt 2005141 cattcggata tggatacata tcggttcatc ctttcttcta aaagcctcat cagattctga 2005201 tctttttgtc cgtttttttc aattccgctg gcaaggtcaa ttccttctgg ctgccatttc 2005261 aataggcgtg tgatgctatc cggattcacg ccgccagcga taaagcagcg tttaccaata 2005321 gccgcctgct gatattccgg cacacattcc caagaaaatg caacaccagt tccgcctcta 2005381 gaccctttta cagatgaatc aatcacaaag ccgtcaacat tatctttaaa gcgggctatt 2005441 tcttgagttg tgttatcttg atggtgaagc gccttccata tttcacagcc tgtcagcttg 2005501 cgaagagcag cagcatccgc cggtttttca tcaccgtgaa gctgaatgac gtcgagcttc 2005561 aagctcttgg caatacgtga catcgtctct attgattcat taacaaaaac acctgcaacc 2005621 tgtttttcga cacgaacttg gttcagccat tttttcacat cttccggaga tacttttcgt 2005681 ttgctttcag caaaaataaa tcctaggtaa tcagcctgtg attccgccgc aagctgcaaa 2005741 tcctttagtg accgaatacc gcaatatttt aatgccggtt tcttcacaac ctcactccct 2005801 aaacaaagca tggattgctt tacgctgaga agtttgtctc atcaatgatt caccgataag 2005861 tacagctcgt gctccatgtt ctttgacaaa tgttaaatgt tctaaagaac cgattccgct 2005921 ttcgctgaca agcagtgatt ctttcggagc aagagatgcg atttgttctg tctgcatgat 2005981 agaggtttca aaagttttta ggtttcggtt gtttatgccg agaatatcag gcgtgaatac 2006041 tttcaatatt tgttctagcg ttgttgcatc atgaacctcc actaacacgt ccatctcctt 2006101 ttcacctgct tcaagatata attcatgaag gtgtaaggga tcaagcactt cgccgattaa 2006161 caatatggca tccgctccga ttcttcttga ttcctccact tgaagagaat caataataaa 2006221 atcttttctg agtacaggta tcgaaacagc gcgctttacg tctgataaat agctgttttc 2006281 cccttgaaaa aacggggtgt ctgttaaaac ggaaagcgca tctgctttcg cagtttcata 2006341 gtcttttgca atccgcacag gtacaaaatt ctctttaata agcccttttg acggcgacgc 2006401 tttcttcact tcagcaatca acccgataaa ccgattcagg cttgccagcg cctctttaaa 2006461 tgaacgtttt tcgaaaggct gctctaccgg cagaaccagt gttttcactt cttctttctt 2006521 ttgtttgatg attttttcaa gcatagatct cttcctcttt ctgctttagt cgttcaagct 2006581 gcgcggcagc gcctccgctt gtaatcgtct ctaacgccag ctccgttcct tccttcagtg 2006641 aggcggtaat tcccgccgtg taaatcgcag cacccgcatt aaaagccgta atagataaag 2006701 cggaactgct gcttttattt tcaaaaatat tctgaatgag ataagcgctc tctttcggag 2006761 actgcacctg taaatcttca agtctgccat ttgtgaaacc gaaatcttcg ggtgaaacgg 2006821 tatactcccg gcgctctccg tcctttaatt caatcacgtc ggtcggtgct gtaattgaaa 2006881 gctcatctaa accgtcacgg cttgatacaa acataacgtg cttcggctga aacgtctcca 2006941 gtgcgcttgc catcagtcca gctttttcaa cagaatagac cccaatcacc tgacgcttcg 2007001 cctgtaaagg attgctgagc ggcccaagca gattaaatac cgttctgaaa cctagctctt 2007061 ttctagtacc tgctacatgt ttcatagacg aatggtaaag cggcgcaaaa agaaatccca 2007121 tgttgtttgt ttcaatgctg cttttgacct tttcgggagt ggtttgaata gaaacctcta 2007181 gctcctctaa aacatcagcg cttccgcttt tagaagagac agagcgattg ccatgcttag 2007241 cgattttcgc accagctgcc gaggcaacaa ttgccgaggc cgttgagata ttaaaagtgg 2007301 aaataccgtc tccccctgtt ccgcatgtat caacaatatc aggaagtcca tcgactgtaa 2007361 gagcgtgtgc ccgcattgcc ttcacaaaac ccgcaagctc ttctggcgtc tccccccgat 2007421 gagcaagaat tgacaatatc ccccccattt cagaaggagt catttccgct gccatcatca 2007481 tattcatcag cgtttcagcc tcaccggcag taagggtttt tccgtcaacg cacaattgta 2007541 gaaatctgtt catcagcttt atcctccttg ctatgaaaca tgtcttctgc aatatgaatc 2007601 gttttcagca gcgcaccggc tttattacag ctttcttcgt attcggcttc cggaacagaa 2007661 tcagcaacaa tgccagcacc tgcctgtatc gatgcaacac cgttctttac actcatcgtg 2007721 cgaatcgtaa tacaagagtc gatattcccg tcaaacccaa tgtaggcaat acaccctccg 2007781 tatgtctctc tcggtgttgg ctcgagttct tgcaaaagct gcatggcacg gattttgggt 2007841 gcgcctgtta aagtccccgc cgggaaagca gacatcagtg catcgacagg atgaacccct 2007901 tttttcaatc ggcctgtaac caccgagata atgtgcatga catgtgaaaa ggaaacaatt 2007961 tttgtgaact ccggcacaga aacagaacca tactctgcta ctctgccgat atcgtttcgg 2008021 gcaagatcaa cgagcatgta atgctccgct ttttcttttt catccttcat gagctcaacc 2008081 ttcagtctct catcttcagc tttgtctgca ccgcgttttc tcgtaccggc aatcggatgg 2008141 atttctaagt gcccgtcttg aacgtgtatt aaccgttccg gagagctgcc gactatttct 2008201 ctgtctagca gtttcatata atacatatac ggcgaaggat tgacgatcct aagcactcgg 2008261 tataactcaa aagcatctgc ttttatcggc acctcaaatt tttgtgataa aacaccctgg 2008321 aagatatcgc ctgcttttat atagcttttg attttttcta catcagccat aaaagccgat 2008381 ttttcataat tagaagatac tgtctcaaag ctgggtgtct tgtatgaatc agcagaaaga 2008441 aacagctctt ttatgttttt ttggtccatc attttttcaa tgagattttg aagctccaga 2008501 tgattttgat ggaatacatc cattttttcg ttttttgttt cctctccagt gagccttgca 2008561 tattggataa agtggacgtt tttggtttca tgatcatacg caattaatgt ccggcaaaca 2008621 aacagcatac acttttccat gtctgtttct ttggtatgcg aaggaacaga aggctcaatc 2008681 agcgggatca tatcatagct taagtacccg acagctccgc cgacaaaagg aatgccaagc 2008741 tcaggtgttt tgattttgta tgtggtattc atccagttca gcacttcttt tagttcattt 2008801 cctgtgtaaa gagatttgct gtcctgatca gcggccgaaa aacggccctg ctcttcttta 2008861 attgtgagaa atggattcag gccgataaac gaatatctgg accaagtgga tgtatcgtcc 2008921 ttgctttcaa gaagatacgt aatctccctg tcaagcttct ctatcatttg aatgggtgtc 2008981 agtgtatcga ctgtgaaggt ctccacaatc ggtatcgtgt ggtgggacaa gctgtcctct 2009041 aaaaatgcgg aaatgtttga ttggaaattc attgctctca ctccttatgg caaggagaat 2009101 gagaagatgg catgagagga taaaatacta tataacaaat aaacccaaaa gaaagacttc 2009161 ttttgggtag aataaacata atgtctcagc tcaactaaac tcattctctg ctaccctatt 2009221 ctctaactca actcattcta attgctttat acacactctt gtgtatttct aagctgttct 2009281 tatcgtatta caattcagta ttttttgtca atgataaatc gggcctcaat acgacaactt 2009341 tttctaaata tacatgtctg atctgatcct gagggacatc tgtctggacc gtcatcatga 2009401 ctcttatgca ctttttcaga ccgcctgtta cgtccatttc ctgcatacat gttaccggta 2009461 catactgcca tcctgaaagc tcgcgaacag cttttgccgg gaaaacagcg tgcaaatcag 2009521 gtgtagccga cagaagcatt tgaacaacat cttccggttt tgtatgattt tcttctatga 2009581 ttttctctaa cagctgttta gttttttgta aaatttcttc ttcagtatcc cgttcaactg 2009641 tagttgctcc gcgaattccg cgaatcatca tgatgtctcc tccaatcgcc atttgttcag 2009701 ccagctctca agttcatttc tggaaaatgt atgatcagca actttcccta attcgttgag 2009761 cacaataaac tgaatcttcc cgccacgggt tttcttatca ttcatcatac ggttcaagag 2009821 aaccgaagtt tccgtctctt ttctgatttg acttggataa cccaggcttt ttagccagct 2009881 gaccaaacgt tttctgtcca tttcacagcc tacagtcttt tcgcttatat ataaagcaaa 2009941 ctgcattccg agggctacgg catcaccgtg agtgatctgc ccatatccat attccgcctc 2010001 aacggcatgg ccgagcgtat gcccaaagtt taagtaagct cttatcccct cttctttttc 2010061 atcctgctga acgacagacg ctttaattga aatgccttta aaaatcatgt cattcagctg 2010121 atcattagtg atatcacgca gtgagtggat attcagcagc tcctccagaa acgctctgtc 2010181 atagataaaa gcgtgtttaa tcacttctgc cattccggac ctaagctctt tttcaggcag 2010241 agaacgcagg aaatctgtat catagagcac ggctttcggc tgataaaacg caccgattag 2010301 attttttcca agcggatggt tcacggctac ttttcctccg actgcgctgt catgcgccaa 2010361 gagcgtcgta ggcatttgga tgaaatcaat gccgcgcata aaagtggcag ccacaaaacc 2010421 ggcaagatcc cctacaacac cgccaccgaa tgcgatgatg catgaggagc gatccatatg 2010481 aaaacgaatc gcttcactct gcaattttgt gtacatgtcc atggattttg cctgctctcc 2010541 actcggtacc gtcacttttt tcacaggcca tttttcttgc agcaaatgga gcatttcatc 2010601 accatacagg cggtccactt cttcatccgt gacaaacata atccttgtta aaggcctgtt 2010661 taaagaggtt aatagttcgc aagccttttt tctgatacct tgtccgataa aaacaggata 2010721 tgacgaggaa gcagtttgaa catgcagtgt cttcattaaa attccctcga cagttttctc 2010781 atattctcca cattttctct aatgcggtca atttgatcta atccgaattg ttcaacgact 2010841 gcgttcgcaa tttcccaagc gacagccgct tcagcgacta cacttgccgc aggaacagca 2010901 cagctgtctg aacgttcaat gctggcagaa aacggttctt tcgtttcaat atcgacactt 2010961 ttcagcggtt tatacaaagt cggaatcggc ttcatgactc cgcggacaac aatcggcatc 2011021 cctgtcgtca tgccgccttc cagtccgcca agtctgttag tagcacgggt gtatcctttt 2011081 tcctcgtccc aaatgatctc gtcatggact tcgcttccat ttcgccctgc tgcctcaaat 2011141 ccgatgccga attccacacc tttaaatgcg ttaattgaca gaacagcggc agcaagcttg 2011201 ctatccagct tgcggtcata atggacatag ctgcccacgc ctaccggcat tccctcgaca 2011261 atgacttcta ctattccgcc gatggaatct ccgtttgcct ttgcttcatc aatggcagcc 2011321 atcatttttt tgcctgcctc ttcatcgtag catctgacag gagactcttc cgttacacgc 2011381 tgcaagtctt caattgacgt atactctgtt ttttcagctt taacagcgcc aatttgcaac 2011441 acgtggcccg ccaccttaat gccaagctca gaaagaatct ttttagctac agcccctgcc 2011501 gccactctga cagttgtttc ccttgctgaa gaacgctcaa gcacatttct catatcacga 2011561 tgattatatt taattgcacc gtttaagtca gcgtgcccag gtctcggtct ggaaatctgg 2011621 cgcttcattt ccttttcttc atcttctgta atcggagcgg cgcccatgat ttttgtccaa 2011681 tgcttccaat cgttattttc aactacgaga gcaattggcg aaccgagtgt acgtgcatgg 2011741 cgcaccccgc tcataatttt ggcctggtct ttttcgatct gcatgcggcg gccgcggccg 2011801 tgtccttttt ggcgtctggc aagctcaaaa ttgatatctt cctccgttat gtaaagcccg 2011861 gcaggtacac cctcaataat ggttgtcagt tgggggccgt gtgattctcc ggctgttaaa 2011921 tatctcatga cttcttctcc cttcatcgca ttaacgcttt taagtaagac tactataaca 2011981 tatttttcag caaaaagtca gtctatcttt tttgataaaa gaatgtatcg gctgggacta 2012041 ggccaaattt ctcgggattg aagatttgct cggtgctgcc gacaaaaaga actccattct 2012101 tcttcaagct atgtgccatt tttaaataca gctcttcctt cgcgctttct gtaaaataaa 2012161 taaatacatt gcggcacacg attaagtcaa agtcttgttc ataacgatcc gccagcaaat 2012221 tgtgcttttt gaatgtaata ttctttttga tttccgtttt cacttcataa cttctatttg 2012281 cgttttgcgt aaaataacga tctttcacag atagcggcac ttcctgtaaa gaccgctcct 2012341 gataaacgcc ttttttcgct ttttccaatg ctttttcatc aatatccgtc gctaaaatct 2012401 gatagcccgg aagacctttt tgctggtcca aaagcatggc aagcgtgtat ggctcctccc 2012461 ccgttgagca ggcggcactc caaattttta aaggcctaga ggtcttgatt aacggcagaa 2012521 ttgcagtctc aagaacttcc catcttttat aattacgata aaattctgaa acattgatcg 2012581 tcattctgtc caatgtttca tttaagagag cttgatcctt ttccaatgcc gcagcaaagt 2012641 ccttaaagct ttggaacccc tttttctcat aaagtgacgt tagccttctc ttcatttgtg 2012701 cttctttata tagtgttaaa tcgactccgg ttaattgttt ccatttcgtt gtaaatacgc 2012761 tgtatgtatc catctctact ctcccagtct cgctgtcttt ttgtcctagt atagcttgtt 2012821 ttatcaggaa attgtattgt ttcaataaaa aaatcagctt ttcagctgat tttagatcgt 2012881 tgggaaaggc agaggtctga tgcacactgc cattcaaccc tttattcact ttaatgtaaa 2012941 cctttacaaa acagaacaaa aaccggcggc gttatatgtt gccggctctg ttgcttattt 2013001 tcacaatgat taatagatcc agcctgccat aagctgctga tatgatacta attcttcatt 2013061 cttaaagaaa atgttaatct cgcgttctgc actttcgaga gaatcagagc cgtggatgat 2013121 gttttttccg acaaacatgc cataatcccc acgaatcgta ccaggtaaag cttctttagg 2013181 gtttgttttc ccgatcagct gtctcgtcac ttcaatgaca ttttcgcctt cccacaccat 2013241 tgcgaataca ggtcctgaag taataaactc aacgagctct ccgaagaaag gcttaccttg 2013301 atgttcggcg tagtgtttct cagccatttg ttcagtcact ctcattaact tggcgccagc 2013361 taattgtaag cccttacgtt cgaatctaga taaaatgtcc ccaatgagct gacgttggac 2013421 accgtctggt ttcaccatga taaaagtctt ttccatcata ttctccaccc catcattatg 2013481 tatgtatagg ctttcacact gcacaccgaa atcgtaacat ctttctgata attaatcaat 2013541 ccggggcgga gaaatttctt aatatctaca aaaattaaaa ttttctttta ccgatatatt 2013601 ttgcgatggc tgcaagagac gagcgtgcgc gccctcgagg aagcgtgttt aatttctgaa 2013661 aagctttctg cagatacatt tcgcttactg ccatagatgc ttcaattgca tctgtttttt 2013721 tgatttcttc aatgattggt tcaagctgtt cctgcgttgt ctcactgtta atcaatttaa 2013781 gctggttttt taatgcagga tttttcaggg catacagcac tggcaatgtg acgtttcctt 2013841 gaagcaaatc tcctcctacg ggtttaccca gctcttcctc agttgaagta aaatcaagaa 2013901 tatcatcaat aatctgataa gacatgccga cgtaataccc aaaccagtac aatgccttat 2013961 gaatcttctc atcagctcca gacgcaatgg caccaagctg gcagctgacc gcgatcaaga 2014021 gagctgtttt tcttttgata cggcggagat acgttctgag attttgttcc atgttgtatt 2014081 tgtctttgat ctgctcaatt tcccctagac aaacttcaac gatcgtctgt gacaaaatcc 2014141 tatgggcttt cggttcgtta attctcgtca tcatttcaag agatcccgca agcatataat 2014201 cgcctgtgta catcgcaata cgattgtccc actttgcttt gattgtcggt tttcctcggc 2014261 gaagctctgc atcatcaatg acatcatcat gaaccaaaga tgccatgtga atcatttcca 2014321 gagtgacggc gacatattta atcttattaa tatcataatc gccaaacatg ccagaaagca 2014381 gcacgaaaac aggccgaata cgtttccctc cggcctgcag caggtgaaga cctgcctcgc 2014441 ttaaaagcgg gtaatcggaa cgtacggttt gttcaagttc tctttcgatt acatcaatat 2014501 cgtcatttaa aaaagagtag gccattttaa atttcatatc attcacccaa acatctgtgt 2014561 tttcatttcc atccgatatg cgtggcagcg actccgccag taaacgaatg atatttaaca 2014621 tttttcaggc ccgcctcttc aaacaggcct gccagttcct tcattccagg gaaatctctg 2014681 gctgattctt gaagccaaga atattcttta tagctcttcg caaacagttt cccgaaaaac 2014741 ggcataatat acttaaagta cataaagtaa gcctgtctga atccgaacat ttccggctgg 2014801 gacgtttcca gacataccac ctgcccgccc ggcttcacta cacgtctcat ctctttcagt 2014861 acagtcaagt aatcagggac attgcggagt ccgaagccaa tggtgacata atcaaatgta 2014921 tcatcatcaa aaggaagctc catcgcattt ccgtgcagca gttcaatttg gctgaatccg 2014981 ccgtctttta ctttctgctc gccgacactc agcatatttt cactgaaatc caagcccttg 2015041 atctcgccgc ttttgcctgc cgcttttgca agagcgatcg tccagtcagc cgttccgcag 2015101 cagacatcaa gtgcttttgc gccttccttt acattcatga tgcgcatcgt tttgtcgcgc 2015161 cattttttat gctgctgaaa actgatgaca gagttcattt ggtcataatt tttatatatt 2015221 ttttcaaata ctccgtgtac gcgctgttct tttgagtcct gcataatggt ttacccttct 2015281 tccactttct gatgataggt ttgatcttgg ctgattgtct tcagacggtt tattaaaatg 2015341 ttctgaatag gtgaatttag aggcagaagt gactcaatgc tgtttttcgc ttttttaaaa 2015401 caatcttcta atatctcttc ttttgttttt cccagctgta taaaactgcc gatcacatcc 2015461 agaaatgcat catttccgtt cataagccgc ttaaatacaa aaaaatcact cgacagcttt 2015521 ttccagcgcg ggaggttgaa gtgttccgcc acacgatgga ataaagctga ttcaacgatg 2015581 ccgacacttt cgaaaaaatc gttttcgtcc ttgaaagaac ggtcatacag acgaatttta 2015641 tgttcgttga tttctttaat ggctgtagca agcgtccgaa tcatgtagat atccttcatt 2015701 tcagatagta aagagtagta cagcccgctg aaataatcgc ccgcgagaac agtcaattgg 2015761 cggtttttgt tttcgtctcg ttttatgact ctagctgtcg tcacttcatc atgggtatca 2015821 agggcgcttt gtacaagcat cgctgttaca atataatttt ctctgtcgtt gttttttatg 2015881 tcggcttctt caaataaagc atgaaaaaga agaagcttat cctcatcaat tttcggcgca 2015941 gaaatatgct tcgctaaata aggatgagac agcttttgtt ttaatttcgt gttcagattg 2016001 gctaaagttc cgtagatgtc ttgcaaaaat atcacccttg tccccaaatt cacatttatt 2016061 tcttaatcta tgtatgagtt ttatcttttc attcgcttac gcaggtatca ttatagcata 2016121 aaaaaaagaa attggctgta tcctcccgct gtttgcgagc atttgctttt aacagcgggg 2016181 acagccagct tatttttttt cgcttttcat ttctccgtac gcggtttgaa tcagtgcctc 2016241 tcctctgact ttaatggcag aagtatgctc tgtaaactga gcgatgatca cttctccctt 2016301 gtcgagtttt tcggaatggt gaaactttgt gtctgttcct cttgtcaggc cgatcacatt 2016361 cactccgtcc tcaacggctt taatgacgac aaaatcactt gaatgctttt ggttcattta 2016421 tagcaccctc tatctttatt agtcctggcg tttaatatgt tccaatactt ctgcacgggc 2016481 agcggcatca tctttaaaaa cgcctctgac tgctgaagtc acagttttcg cacccggttt 2016541 tcttacaccg cgcatcgtca tgcacatgtg ttccgcttca accactacca ttacgccatg 2016601 cggatcaagc gtttctacga tgctttctgc aattgtagaa gtgatgcgtt cctgaagctg 2016661 cgggcgcttt gcaacggctt caacggcacg tgccagtttg ctgagtcctg tgacctttcc 2016721 gcctcgcggg atatatgcaa catgtgcttt tccataaaag ggaacaaggt gatgctcaca 2016781 catagaatga aacgctatat cttttacaag aacaagctcc tcatggtttt caccgaagat 2016841 agtctggaaa tgttcttttg gatcttcatt caagccggag aatacttcgg catacatctt 2016901 tgcgactctt ttcggagtat caagaagccc ttctctattc gggtcttctc cgatcgcttc 2016961 taaaatttga cgaacagctt gttcgatttg ctctttatta acttctttca tgttctatgt 2017021 cctccaccaa tgaatacatt taatttcgat tctagcacat atgccccgct aaaagcaaag 2017081 tgaatgccct gtcaggaagc ccatgctctt gaaatatgaa aagcccctta gaaaggggct 2017141 tttctgtgaa gaaataaagt gtatgtaagc tagatgcata cacgatctat attcacaatt 2017201 attttccggc aactgcgtct ttaagcgctt tacctggttt gaaagcaggt actttgcttg 2017261 ctggaatttc gatttcttca cctgtttgag gattgcgtcc tttacgtgca gaacgttcac 2017321 gcacctcgaa gttaccaaaa ccgatcagtt ggattttatc accgttttta agtgcatcta 2017381 agatcgtatc aaaaacagag tcaactgctt ttgtagcgtc ttttttagac aattcgcttg 2017441 cttctgcaac cgcattgata agttctgttt tgttcatgcc tttcacctcc tcccaaaagg 2017501 atacattcag ttcgtttatt atcatttctt cacagttcag tctgattcta aacctgtctc 2017561 agaaaaaaat gagagcaagt aagagaaaga caattaaacg gctttttaag aaaaactgca 2017621 ctctgaggaa tgtttgtcca acaaagtgaa gaatttctgt atgtagagta acacatataa 2017681 aaagccatat caagcatttt aaagcgtcaa tcccttgctc gtcaaggatt taaggtgatt 2017741 taccgaacga atattccttt ttttcctttt ttcatcctat tccttgatcc ttttccatta 2017801 ttaagagcaa agaaaaaaga cctcccattc tataaagagg tctaccggta ttacaggatg 2017861 atggcgatta agccgccaga gccttcgttt atgattcttt ctaatgtttc ttttaattta 2017921 taccgtgcgt tttcaggcat caatgacagc tttgcctgaa tcccttctct cacaattgag 2017981 ctcagcgacc ttccgaagat atcggaattc cagatggaga gcggatcatc ctcaaagtcc 2018041 tgcattaaat agcgtacaag ctcttcactt tgtttttccg ttccgataat cggggcgaat 2018101 tcgctttcga catctacttt gatcatatgg atcgacggag cgacagcttt cagcctcaca 2018161 ccgaatcgcg agccctgcct tataatttcc ggctcatcga gactcatatc agctaaagca 2018221 ggcgctgcaa tgccgtatcc cgtctgtttg accattttta aggcatcaga cacttgatca 2018281 tattctgttt tcgcatgggc gaagtcttgc atgagctcaa gcagatggtc tcttcctctg 2018341 atttcgacgc ccacaacttc ttttaggatt tgatcatata gatgatcagg cgcgtacaaa 2018401 tcaatttctg ccaccccttg gcccagctca attccggcta atccggcact ttcaatgaat 2018461 tcaaactcgc tgaattggcc gacaaccctg tctacgtccc ggagccgttt aatatcctta 2018521 accgtttcct tcacggactc ctgatagctt tcacgcaacc aatggttttc tttcagcacc 2018581 attacccagc ttgggagatt gacattcact tctagcaccg gaaactcgta gagggcctct 2018641 ctgagcacac tcagcacatc tgattcccgc atgctctcta cactcattgc caataccggg 2018701 atatcatatt tttcgcttaa atcctggcgc atggcttccg tttccgggtg atacggcctg 2018761 actgagttga tgaccataat aaaaggtttg ccaacctctt tcagctcttc aatgactctt 2018821 tcttcagcct ctatatagtc acttctggcg atatctccaa tggtgccgtc tgtcgtaatg 2018881 acaactccga tggtcgagtg ttcttgaatg acttttcgtg tgccgatttc agcagcctca 2018941 tgaaatggga tcggttcttc gtaccaaggc gtattgatca tccgcggccc gttttcatct 2019001 tcatatcctt tagcgccggg cactgtgtaa cctacacaat ctactaatct tatattcaca 2019061 tcgagtccgt ctgacacatg aacagacatc gcctgattcg gaacaaattt aggctctgta 2019121 gtcataatgg ttttgccggc tgcgctctgc ggcagttcat cctgcgctcg ggcccggtct 2019181 gcttcgttac tgatattcgg gagcaccaca agctccataa attttttaat gaacgtggat 2019241 tttcctgtac ggacagcacc tacgactcct aagtatatat cgcctcctgt tcgttcagcg 2019301 atatccttga aaatatcgac cttttccaag tgatcccctc ccggacttcc tatccttttc 2019361 aattttatta agctctttca atcaaacaca ggacactata tgtgtatgac gttgtcctat 2019421 ttgaatatga catctttaga aaatttctca tcctcaatct attaatataa aaaaaccttt 2019481 ctccctattt gtatgcaagg gagaaaggtt cattcctttt tcatatcatt ttctaaaaaa 2019541 acaggttcct gtttgtcatt taccgtatat tttacagaaa acgcggggac aaagggggtt 2019601 tcatgccaaa tcatatcctg gatttcagtc ccgggtttaa acgttttttt gctttttttg 2019661 aggcaagaag ccagctcagt ccggtaatcg gcatatattt ctccgtctcc gtcaatcata 2019721 agcggcaagg aattccctga gattgggctt gtcactgtaa gagagctgcc atccccaagc 2019781 ttcttctcat cgagtgtaaa taaatcacga gatagcacat ccttgtaagg cggatattga 2019841 tgctcctgac gatacatttg gatgcgcaat ttcacatcgc gaattttttc tgccatcttt 2019901 agatcaatta atttaacagt cggatcgttc tctacgtcaa caagcacgta ttgatagtct 2019961 cccccgcttt caaatgccgt acttggaggt tcagctatgt atcttggcgc taaccggtta 2020021 aagtctatcg gatatttttg atatagcggt gtcgacatat ctttggtttg aataggaagc 2020081 agccctccat ttgccttttg aaattcatca acagcagatt gaacctgctt tagctggtct 2020141 tgataaggaa tggcatgcac actgcttttc cgttcatttg gatataaaca tccggataaa 2020201 aacacgactg ccgcaaaaat gattgcgcac ttcagtttac ccatacagca cttcctttta 2020261 cagctttatt cattgacagg gccgctaaaa accacgacaa acacaataat tccagatatg 2020321 agcatacaca tgtatgcgaa tgatgaaatc gcaatcttca aaaaacggtt ttggcactta 2020381 aagcggctta aatagatgga agctacagcc agaaacatca gacccatgga ccctagagca 2020441 aaccacattt tcatcaatgc cagattcaat gacgtgcgcc tccccgatat gtaagatata 2020501 agcgttatat tatattttaa tatacagcgc cggaaaagat caaccagatt ttccatccat 2020561 tgatagaaca aaaaaactga agcaaagagg gggaccttcg cttcagtcaa cttgactata 2020621 ttcacctgca cgtttaagaa acactctctt ggacttcgat gctatagtat gcgacttggc 2020681 atacagatgc atcctctatt gcctaaatcg gcaaaatgtt tcaggagatc ccaagacttg 2020741 ggtgttcttc tgtttttcgg gctttcgttc aattaagata tgcgattcac catttgattg 2020801 acacttttac ttcacttgat tttcaaacgt atttaccaaa tcctccatct cgtgggtttt 2020861 ccctctcgcc attaaagatt caacagcggt ttccactttt tgtccgttga ataggacctg 2020921 atggagagct tctgtaatcg gcattttaac atcatatttc ttcgaaagct gataagccgc 2020981 tttcgtcgtg cggacgcctt cgactaccat tcccatctct tcaagaacat cttcaagctt 2021041 gtaccctttt ccgagcaaat tgcccgcacg ccagtttctg gaatgaacac ttgtgcacgt 2021101 cacaatcaga tcgcctactc ctgtcaatcc agagaacgtc aagggatttc cgcccatttt 2021161 cgttccgagt ctcgcgattt cggcaagtcc gcgtgtaatc aaagcagctt tggcattgtc 2021221 accgtaccct aaaccatctg taattcctgc agcaagggca ataatatttt ttaaagcccc 2021281 tccgatttca actccgataa tgtcaggatt tgtgtacacc cgaaaattgt gattaataaa 2021341 tagatcctgc acctcttctg ctgccctcat gctctttgaa gatgcagtaa cagttgtggg 2021401 gtgccgcagc cctacttctt ccgcatgact cgggccggaa aggacaacga tatcttttct 2021461 gacatcactc gggagctcaa tttccataat ttcagaaatg cgcagaagtg aatctggctc 2021521 aatacccttg ctgacatgaa caaagactgc ctttttcgtt ataaaaggga cagcctgtct 2021581 cagcacttcc cgaattgctt ttgtcgggac cgcaacgata atgacatctg cgtctgaaac 2021641 agcctctttc atatctgttg ttcctttaat ggatgtagac agcttaacat tcggcaaata 2021701 atctttgttt tcatgcaact cattaatttg atgaattaaa tctgcacggt gagcccacac 2021761 acacacttca tttccattat cagttagaac taaagccagt gctgttcccc aactccccgc 2021821 tccaagcatt gtgacttttt tcatgtttga ttcacacctt tttattttct agctcttgca 2021881 aatattttga ttggtgtccc ctcaaaaccg aacgcgtctc tgattcggtt ttctaaaaac 2021941 cgttcgtatg aaaaatgcat cagttccgga tcgtttacaa acacaacgaa gcttggcggc 2022001 tttaccgaca cttgagtcgc atagtaaatt ttcaaacgag aaccgttatg agtcggtgtc 2022061 ggattcattg ccacagcgtc catgatgaca tcatttaaga cgtttgtttg aactcgaagt 2022121 gaatgatttt cactagcttt gataatcgca ggcatcagag tatggatccg ttttttcgtt 2022181 aaggcagaca taaataggat tggcgcataa tccagaaatt gaaaatgatc gcgaatattt 2022241 tcttcaaatt ctttcatcgt gctctcatct ttgtcaacag catcccattt gtttacgacg 2022301 atgacgacgg ccttgcccgc ttcgtgtgca taaccggcga tacgcttgtc ctgttcaata 2022361 atgccttctt cgccatccag cacaaccgcc acgacttctg agcggtcaat cgcttttagc 2022421 gcccgcagta cactatactt ctcagtcgtt tcatagactt tccctttttt tcgcatacct 2022481 gcagtatcga caatgacaaa ctcctgctgg ttgtaagtaa atgacgtatc aacagcatct 2022541 cttgtcgttc cagccacgtt gctgacaata acgcgttctt cgccgagcat cgcattcaca 2022601 agtgaagact ttccgacatt tggacgtccg atcagacaga attgaataac ttcttcattg 2022661 tatttcgttt caggaatgtt tttaaaatgc tctgcaacgg catccagtaa atcacccagt 2022721 ccgagtccgt gtgttcccga aattggatac ggctcgccaa agcctagcga ataaaaatca 2022781 taaatattcg ctctcatttc tgtgttatcc agtttattaa ccgctaaaac aacaggcttt 2022841 tttgtgcggt acaaaatttt cgccacttct tcatcagcag ctgtcacgcc ttcacggccg 2022901 ttcaccataa aaataatcac gtccgcttca tccatggcga tttcagcttg ctggcgaatc 2022961 tgcgctaaaa acggctcatc accgatatca ataccgcccg tatcaatcaa attaaaatca 2023021 taattcagcc attcagccga gctgtatatc cgatcccttg tcacgccagg ggtatcttct 2023081 actattgaaa ttctttctcc cgcaatccgg ttaaagattg tggattttcc tacatttggt 2023141 ctcccgacaa tggctacgac aggtttaccc atagtaccct tcctttcaat ccagccgctt 2023201 tcatttttac ataaattttc aaccggttat taaaatcatt tcattcactt ttatgaaaag 2023261 aaacccttca gaggaagggc ttaactcatt tattatatca gtttttactg ggatcacaac 2023321 tattcttaaa aatgtttcac gatcaaatac acgtcatctc cgattctgtg agctattcca 2023381 tcaaggatcg cctcaagatt tttagcgaaa agctccatct ccttttggtc attgcaaaaa 2023441 aagacaggtg ctccccctgc aacccgattt cgatttgtcg tgattacaga caaaatcact 2023501 ttcgtaagag attcactcat cctatcacct tatcctgatt cttgataaat tcagtcggca 2023561 ttctaatcgc attttccagg gttggaacat tgctaataat ttgaacagcc gtttcgggat 2023621 ggtgaatttg cgggagaaca aatactgcca ctctcccatc atttaaatcc cgttttgcaa 2023681 ttggtgtcaa agatggctct cctgaatccc gataaacccc gagcacattg gaaacatcaa 2023741 ataaaatggc ctgacgctgc cctaaatttg ctatcgtcgc tgctgaatta aagtttttcg 2023801 gcgtcaaaat aaagcccatg ccatgcttta aaatcagttc ctgtttctct ggaagcccga 2023861 tattcatcat ataaatatta tcaacaaaca gtcccggacc gtcaaagcgc ggctttatgt 2023921 actcgatatc tacaatatcc ttcaacacac tgcccgacat aaacttcatg gccagtaaaa 2023981 aacaaacgac agccgctatg actgcagccc agatggataa aaacacatac gcagaggttg 2024041 tcaaaagcgc tgtaaagatc acaatataat ttctgctttc aaacgcaatg gcaatcccct 2024101 caatatatgt gcttcccctt gagacaagtt catacgaatc catttgcgtc aatgtgttcc 2024161 gctccatgtt tcggacatct ctaaattgcg tcgctgccaa tgttaaaaat gtgatggccg 2024221 taaattcctc ctgcaaaagc gccggcataa taattgcacc taaaccagcc gctatcaacc 2024281 ccagtgcgat gtgaatcact ttcccatgaa cataggtcgg atactggcgg taatccgttt 2024341 tcagcatata aagccttgtc gcaattccgg caatgacccc agcaataatc ggatagatgt 2024401 aatcactcat gacattttgg tagctccttt gtttgatctt ttgcttttct gaccaatctg 2024461 gcttgcgagg tgttcgtatt tagatatgcc aaacagcaat atcatccccg cagaacacgc 2024521 attcagccat tgaaagccgc cgacagccat agccccggcc aacttctgga tcacaaatga 2024581 atacaccagt tcgccttggc acatccctag gacaaataag acaagctgct tctcaaaatt 2024641 cctttcaaca gaagctgtta aaagcactat taatataaca gcagcccact caggttttat 2024701 gatgaaccaa accgggtcat ataatgcaaa aagataaaca aacgcatacg cggcaacaag 2024761 cgtcagatag accatgatgt aacgaaaacg atacattccc aaatacccgg catagacaca 2024821 tccgcaaacg aaaaacatca aatatgcagc attcagggaa aaatataaag cgatgtcatg 2024881 tatgcttaga ataatattag ttaaaataaa gacagagacg gcaattcgtc ttttcgtctt 2024941 ttcaaaaata aatgttgtca gaacccacag aaaccacatt gaccaatagt aataaaattg 2025001 ttccatttta cttcctccat attcccagta tggagttcaa gcacattttt taaacaatcg 2025061 atctcacatt aaggagtatg atcatgggaa aagacagaca agagaaaaaa ctcaaagctt 2025121 caggcagagt cgaatcagat cgcgaccagt ccattcacta tgacggagcg acaagccttg 2025181 aacaaaacgg aagattcaaa aagcgaaaat cataatacaa aaagcccaaa ccacatatgg 2025241 ttttgggctt ttatcattta tcgcacacta tagcttgatg tattgacccc tctctctgtg 2025301 agccaatgat gggtttcacc tttgatcaca aggggcgcct tttgtaaatc ggcaattgtt 2025361 ctggcaccca gcacggtcat aatcaacttt aattcctcaa ggatcagctg aatctcctca 2025421 agcagtcctt cctcaccgct gtcagtcagc gcttttaaaa aatgccctgc cattccggtg 2025481 caagaggccc ccagcgcaat tgcctttgcc acgtcaagcg catcttgcag accgccagag 2025541 gcgatcatgg tgcttgcagg aaactcagag cggatttccg ccaaacttgc agctgtcgaa 2025601 atgccccacg aattaaaaaa ggagatttgc cgctgtcttc ggagattttc gattttcgag 2025661 aaatttgttc ccccgtaacc gccaatgtca acagctgcag caccagcttc atacagcttt 2025721 cctgctgatg ctttgctcat accgaagccg acttctttca caatgaccgg tacactgacc 2025781 cggctgcaaa tttgttcaat gcgtttcaat gcgccgctaa agcttctgtc cccttcaggc 2025841 atcacaattt cctgaatcac attgaggtgg atctgcagtg cgtttgctcc aatcatctca 2025901 acggcttcct ttgcctgagc agccgttgcc tcgcttccca ggttggcaaa aatcagcccg 2025961 tttgggtttt cctttcgaac aatttcatag gaaagacgct ctgatggatc ttttaatgct 2026021 gacatttgcg atcccacagc aaggggaatt ccagcctgag aagccgctcg cgcaagcgat 2026081 ttattaatct catatgtaag ttttccgccg ccgccagtca ttgcattgat aaaaatcggc 2026141 gaactgcttg aaagttcgcc gatttttgtg gaaatatcta cttgttctaa tgcaagatcg 2026201 ggcagactga cgtgaacaaa cgtaatatca tcaagacctg tttcccgctt ctggccgatg 2026261 gacaaggcat gattgatgtg ttgtcttttt cgttctgctc gagtcacgtt tatcaccaat 2026321 tattttagtt tattcagctt atctccgatc agatctccaa gctggaagcc agtgcttgtt 2026381 tcttccttcg cttgatattg acggtaatct tcctggtcag ctttaggcgt ttcttcaagt 2026441 tcacgcatgc ttaatgaaat gcgctcctca ttttcattca catcaagaac cttcactttt 2026501 acagtctgtc cttcttcaag gacttcatgc ggcgtgccga tgtgtttatt ggaaatttga 2026561 gaaatatgaa cgagaccttc aacacctgga aggatttcaa caaaggcacc gaagcttaca 2026621 agacgctgta cagttccttc aagcacatcg ccaggcttca ctttttcgcc gatttggttc 2026681 caaggtccag gcagtgtatc tttgatcgat aaagaaatac gttcattatc acggtcaacc 2026741 gataacactt tcacttttac ttcttgtccc tcttcaacaa cgtcagacgg cttctctaca 2026801 tgagagtggg aaagctgtga aatgtgtaca agtccgtcga tgccgccaat atcaacaaac 2026861 gcgccaaagt cagtcaggcg ctgtactttg ccatcaagta cacttccaac ttcaagagac 2026921 tgaagaagtt cttgtttttt attcgcttgt tcactttcaa caacagcacg gtgtgaaagg 2026981 atcacgcggt ttttatcacg gtcaagctct acaacgagca gtgacagtgt ttttccttta 2027041 tagtcagtga agtcttcaac gaaatgtgct tcaacaagtg atgccggaat aaaaccgcga 2027101 acgccgatat caacgacaag gccgcctttc acgacatctt tcacttcagc ttcaaacact 2027161 tcttttgttt caaatttttt ctcaaggtct tcccaagcgc ggtctgcatc aacagcacgt 2027221 ttagataaaa tcaaagcatc gtcttccact tttgttactt tcaggtcaag ctcgtcgtct 2027281 actttaacaa catccgatgc tttctctaca tgaagacttg ataattcact gattggaata 2027341 ataccggatt gtttgacatt gataatttct acatctacat gtttgtcttc tacctttgtc 2027401 acaatccctt taactacatc tccaacctct ggcacttgaa catcaatttg attcatttcc 2027461 tctgtcattt gaataacctc cttggtccaa acctacacag cttaattaaa acggtttgaa 2027521 agctgaacat ataacatgcc cgcttttagc cgaatatgta ttaaagaatc atccaaaaaa 2027581 gttttttgaa tgatcaataa aaagttttat tagtattaac ttctaataaa aggacaggtt 2027641 tgtcaagcaa taacattcta tcttcgttga aaaattcaaa aaaagtggca tttgccatcc 2027701 tcagcgggac ttttgctcca cagcctcgag gattttatca gctacctctt gaatggaaag 2027761 cgatgtcgtg tcgatttcaa gagcgtcttc tgctttacgc agcggagata cttcgcgctc 2027821 tgaatcaagc ttgtctcttc ttgcaatttc ctcaattaat gtttcgtagt tgacatcaaa 2027881 gccttttttc acattttctt cataacggcg tttcgctctc tcttccacag atgccaaaag 2027941 aaagattttt acttctgcat ttggcagcac atgcgtcccg atgtcacgac catccatgac 2028001 gacgccgcct ttttccccaa gctgctgctg gcgtttcacc atttcttctc tgacacttct 2028061 gtgcttggcc gcaattgaaa cttggttgct gatttcatct gttctgatcg cctcagttac 2028121 atcggtgccg tttacaaaca ctttttgtcc atcttttgtt gtaatcagct caatgtctgt 2028181 ccgctttagc agctcagcca gtttttcttc atctgtcaga tcaacgtttt cctgtaaagc 2028241 cgcgtacgta atcgcccgat acatcgctcc tgtatcaata tatatgtacg attttttctc 2028301 agccacaatt ttggcaacgg tgcttttccc cgcagctgcc gggccgtcga ttgcaatcga 2028361 taatttcttt tccataattc ctctccttgc tcttttctcc tctaaggatt gtatcacgaa 2028421 ctttatgaaa aagggtgaaa aattgatgaa taattaatgt ttgaaggttt caatcctatt 2028481 gttttcctcc attttatcca ccccttcata ttgaatcact tttgatacgt atggttcaat 2028541 atgctgatag tgaaaaagaa attggacacc aagtaaaatg atggcctgaa tgaacaataa 2028601 tttgatcagc agccgttcaa atgttttcat tggagcacct ccattacaaa tagtatggaa 2028661 gtgtttgccg atgtttattc cattcgggcc tttcttctct tatttaactg gcgcctgatg 2028721 cagtattgaa gcaaagcctg ctggtcacct gctgcaattt ctgaatactc taaagtcatt 2028781 tttcgttttt ctgacttggg gtcattaaag attcgtctga caactgcttc tgtttctatt 2028841 tgacgtgtgt gctcctcttc aggaagacgg atgatcaggc gcaatgattc ccccgattga 2028901 aaagaaaggc catcagctaa aaccacggcg atgccgcctg cactgatgtt ataggatagt 2028961 gtgcggatct cttcttcatt tcccggctga atttgcacat ctaataccgc atcagttctt 2029021 acatattggc ggcgctggat tcttttcatt ttttcacggg gaggcatttc aagacagatc 2029081 atttgaagtt tgtccttcac tttacctttt atacggctta taaagcgata aggaacttcg 2029141 tcttttccca caaactctac cgttacttcc atatcgttat gtaaaatcac agttcgccct 2029201 gtaactacat caacaggata cgcgatcaaa agttcattgt tttcgatgct gaccgccttg 2029261 ctttttgcct ttttcaattc attttcttct atatattcta aaagtacatt ttctccaatc 2029321 tctatcattg acttcactct ttcgcattca atatactcac gtttttatta aagcacgtaa 2029381 tgaaaaaaag gaaaagacat ttagtccttt cctcctgttt ttataggtct ttatatatag 2029441 gttctgcatt ttttagtttt tcaacctttt cttccgatcc gtctttggca ttgatataca 2029501 ttctgaatgt gtcattttca attgtcccaa gcatttcgta gcataacact tcttgaccta 2029561 gttcatttgt aatcaaagcg agccttgttt ctctcacttg tacattttta tttaatttag 2029621 actttgcctc tgcttcagta attgcaggct taggtatggt tctttttctg tgagatgtga 2029681 ggaagtctct tgctgaaaag ccgacaacct caccgtcatc caaggccact ttcatacgaa 2029741 ttgcctcggg gtacatccgg actttatttt caacaggaac atatgaaaat acaccgattt 2029801 tatcatattg ggcactttca tcaatttcca aatcatctgt ttcaaatccg tttttcttta 2029861 aaaatgcaag cgctcggttc gatccgtcat ttaaactgat tttctgatct ttcacttctc 2029921 tgttttggat caagtatacc ggatgcccgc ccttcttcgt aatatccata taaatcactg 2029981 ctttatggtc tgggtctttc atgctgatgc tatatacatc gcgatttgtt ttttttccgc 2030041 tctttaccac tttaattgaa taattgtcat ctggggcaaa gcgctcagca atttgttttg 2030101 cttcctgttc ggaaatttgt tttcccttca gatggctgaa gcctttctct tcttttttcg 2030161 tactggtgaa actcgggcca agatcagtgc cagtggagaa tgcaccaaca tttttttcga 2030221 ctgttttaaa gctgttgata atcgtattat cactttgttt ttcgtcagaa gccagagcca 2030281 tttctacgtc catccagcga aggtttttgc tcatgacaag gtgctgaaca tgacgcaatt 2030341 cattttgtat atcttcggac tgctgatata gcttatttag tgatgtatac tcgtttttat 2030401 caagcggctt ttggtccaaa tctctgactg acgttttata gctgaaatcg ccgatctttg 2030461 ataatagctc ttcagtttta ttaaacggca ttaatgtaag cggcagctga ctgacgctgt 2030521 tatgagcttc tgatgtaatc ctccacacat cgatcaatgc aggcgacagt gatttttggc 2030581 tgttcatggc aagtgttgtt ccgattttat catgaagctg atccacctga taggtaagct 2030641 catgaaacgc ccgctgatag ttattttcag catgaagaag aactgcgtct ttttcctggt 2030701 gttctttgta tccccagtag cctgtaccga ctattgcaat accaagcacg gcgattaaaa 2030761 ttcctctgat catttatcac acctcttttt atgctttctc atatctgcta ctcacagaaa 2030821 atgtgtttac cgattctttt aatctgcgga cgcccccaaa tccacggact tgtagccgta 2030881 tccggattaa agtagtaaag tgcttcctct gatgggtccc agccattgat ggcatccagc 2030941 actgcttctc gtgccgtttc attcggctgc atgtaaattt gtccgtcggc tactgctgtg 2031001 aaggcaagcg gctcaaaaat aacccccgct actgaatttg gaaataacgg gctgttcaaa 2031061 cggtttaaaa tgactgctgc aatagcaacc tgcccctcgt acggctcgcc ccgggcttcg 2031121 ccataaaccg cttgagcaag cagcctgata tcgttgttgg aaaatccacc aggcatgttc 2031181 gctgctaccg catcctgttt tcttgctttt gctggtgtat tgttttgctg tttattcgca 2031241 ttcgctttag gcttctgcgt tgttttttcc gcaggctgtt tctgccgtgc ttctgcttgt 2031301 tgtcttgcct tttgtgttgc tgcttttgat ggtttcgtct gatactttag cggaattttt 2031361 ccgtaatgcg tgaatgtatt ccctttattg agctgttcca tgacatattc acgatagtat 2031421 tttgatttac atattaaggt ttgctttgtt ttagctccta caaggccgtc aacctctttt 2031481 aacccgaatt gatcctgaaa atttcgaact gcccagtacg tcccccatcc ataaaccccg 2031541 tcaatttttc cgttataata tccgttgtat tgaagacgcg cctgaagctc gaccacatca 2031601 tcccctgttg cccctctttg aatgacctga ttcgaaaagg cagagatcgt ttcagtatta 2031661 ataaacgtcg ttattgtaaa ggaaaaaagg atgagacatg ccataatcga tcctttggac 2031721 ttcatctttt caagcctcct actgcaaatt tttaagtgta atcgtatttt ctgtaacgag 2031781 gttattttta tacactcttt ccttgttatc cctcagaaca taaaaactgc acacaaaaaa 2031841 gccgcacggt tgctgtgcgg cttctatact tgcatcatat taacggaacg ggcttttttc 2031901 gctttacgca aaccaaacca ccataaaaat accataaatg gaagcatata ataaatccaa 2031961 ttgctaagcg ctgttaggat aaaatcatat gatccatgca aaagggatgg gacaactaaa 2032021 gaaagagtaa gccactttac acgcgcctta tcagcggaaa aacgggcttt tccaaggtaa 2032081 aatcccatta taacgccaat caaggcatgg catgaaacag gcagcagcgc cctgacaaac 2032141 gcatgctcca cgccgtggcc aattaaataa agaatatttt cgagggttgc aaaaccgagt 2032201 gatacacttg caccgtacac aatcccgtca taatgctcat caaagtgggc gtgcgggtaa 2032261 acactgatca tcagtataaa ccattttaat gattcctcca aaaaccccga agataaaaaa 2032321 gaaacgaaaa agcttccgcc tcctacattc tctttttcaa gtacatactg gataaacatg 2032381 atgggaaata caagaacaac cccgagaaaa aacgaccgta gcaccatatg tacaggttca 2032441 ttatcatact gatcttttaa ataaaaataa cttaataacg cgatgccggg ggcaattcct 2032501 gcagagatga ttgcaaacat caggcaacct ctttccttta tattcctaca tctatcctac 2032561 catgttgttt aaaattttac atctgtctgc acttaaaaaa acaaaaagag catacgaatg 2032621 catcatatgc tcctcatctt taatggtttt ctcttttggc gatttccgct gcgatatgcc 2032681 ccccgtgaaa cctgccgttt tcaataaata tttcatttgc attgtttccc gcagcaataa 2032741 caccggcaat aaagacacct tcaacgttcg tttccatcgt ttcttcgttg aaaaatggac 2032801 gccctgtttc tttatcaatt tcaacaccaa ttttttcaag aaattgatga tcgggatgat 2032861 agcctgtcat ggcaaataca aaatcatttt taatggtaat gagttctttc tctccggagc 2032921 gaaacacaac ttcattctcg gtgatttttt cgacacaagc tccaaattcc atacggattg 2032981 taccgtttct gacgagagct tcaaattccg gcagaatcca cggcttaatg ctcggagaat 2033041 actcattgcc cctatataaa actgtgacac gcgccccaga tttcacgagt tcaagggcgg 2033101 cgtccacgct tgaatttttc ccgccgatga caacaacatc tttatcaaaa tacgggtggc 2033161 cttctttaaa ataatgaaat actttcggca aatcctcacc gggtacgccc atatagtttg 2033221 gatgatcata atagcctgtg gcgatgatac aatatggcgt cgtgtaggtc tcttttgacg 2033281 tctcaataac gaatgtgtta ttttgcgttt tcgtcacttt acgcaccatt tcaaacgcat 2033341 taacacggat gtttttccgt ttaacgactt cccggtaata cgataaagcc tgaattctga 2033401 caggcttcct gttctctgta ataaatgcca catctccgat ttcgagcttt tcacttgaac 2033461 tgaaaaaggt ttgatgcgtc gggtaattgt aaatactgtt aacgacattg cctttttcga 2033521 tgacgagggc atcaatgcca atttgtttta ggtgaatggc agcagatagt ccacaaggtc 2033581 ctccgcctat aataattgct ttttcttgaa tcatttctgt caactcctgc gattggcatt 2033641 tcacttcata ttttctattt ccgaataaaa aaatctccta ttttatcata ggagattttt 2033701 tatttttatg caaatcatca acttatatcc agcctctaaa acgcgaagct tcagccattt 2033761 tgcgaacgcc gaccatatat gcagcgagcc tcatgtcaat tcttcggttg ttagccattt 2033821 cgtaaatatt gttaaatgat ttgaccatca ttttttctaa tttttcttct acctcttctt 2033881 cactccagta gaagccttgg ttattctgaa cccattcaaa ataagaaact gttacgccac 2033941 cggcacttgc cagcacgtct ggtacaagca gaatgtcccg gtctgaaaga atttttgttc 2034001 cttcaagcgt tgttggtccg ttcgctgctt caacgacaat tttagcccgg atattatggg 2034061 cattttcttc tgtaatttga ttttcaatcg cagcaggaac gagaatatca caatccagct 2034121 ccagcagctc ttggttggta atggtatcgt tgaaaagctt tgttacggta ccgaagctgt 2034181 cgcgtcggtc gagtaaataa tcgatatcaa ggccttccgg atcataaagt ccgccatacg 2034241 catctgagat gccgacaact tttgcccccg catcatgcat aaattttgcc aaatagcttc 2034301 ccgcgtttcc gaagccttgg acaacgacac gcgcaccttt aatatcgatg cctctcttct 2034361 tagccgcttc tttaatacag atggtaacac cttttgctgt cgcagattct ctcccgtgag 2034421 atccgccaag cacaagcggt ttgcctgtaa taaatccagg cgaattaaat tcatcaattc 2034481 ttgaatactc atccatcatc caagccatga tttgtgagtt tgtaaataca tccggtgccg 2034541 gcacgtcttt tgtcgggccg acaatttggc tgatcgctct gacataccct ctgctcagac 2034601 gctccagctc tctaaacgac atatcccttg gatcacaaac aattccgcct ttaccaccgc 2034661 catatggaag atcaattatg ccgcatttta aactcatcca aattgaaagc gccttcaccg 2034721 ccttcacctc tttttctgtt acgttcgggt gaaaacgtat cccgcctttc gttggaccga 2034781 cagagtcatt gtgctgcgca cgatatcctg tgaaaatctt tactgaaccg tcgtccatac 2034841 gaacaggtat ttttaccgtt aataatctca tcggctcttt taacaattcg tatacctctt 2034901 cgggatatcc caatttttcc agagccttat gtattacggt ttgggttgat tttaatacat 2034961 caagtttgtc ctcttctgta tgaccggtgt ttcgatcggc tgccatttga gttaacctcc 2035021 tagaatcttc tgtttctcac atgctccctt tcagagaata gtatacacct tcatatgatc 2035081 tgtgcataga ataaacgtta tgtttttcca tgttttttaa cgaaaaaaaa ctgctgaaat 2035141 cagcagtttt ccgttgcatt cttatgaaaa atgagtttgt atcgtttcta cggcattacc 2035201 gtccataatg agcttaccat actcttgcag gcgataaatc gttaaagttg tcggattgcc 2035261 gtattcagcc agaaccgcca caaccccttc agccgtatgt gaccctagat cttcaaggct 2035321 taaaaagtac tgcccgtcat agtggtagac agttccccct gtgataccga ttcgctgtaa 2035381 gctttctgaa agctgaatga tatcttcaaa ggaatggaat tgatatatga tgtccgcgct 2035441 ttcatcaagc ttgacttgca tttcgatgta atcatcatca tactcatcgt cttctgaatc 2035501 ggcgtcttgg ttctttgtta caatcacgac catcccttgt gcttggagag aatacacttc 2035561 cactgcaatc ggtccattcg cttcaaagcc gagctctgta tttgcttcat tcatcatatc 2035621 tttaaataac tggtggactt taaatgagtc cttccagagg tcttcttttg tcaatccccg 2035681 gtctgtcaaa tcatcgaggg ttaaaaagat tttgatctta ttataattca gacgctcaag 2035741 ccgcataacg ttccctcctg cctctacttg cacacaaatc atataacaca ttatatgaga 2035801 tgatgagtca taggttctta attgttatca gtttacactg agttcactag taagacaagc 2035861 acaatgcagt ttttattgcc atacggattt ttgcttttta gaagttattc tggcccgcaa 2035921 agagtcacaa tgtgagtttc aggctcagca cctaaacgaa gaggcacttt tgtcgtgccg 2035981 tagccgttgc tgatcagata tgccgcgttt ttaacaatac ctgttttccc cagttcataa 2036041 ggaccgaatt ttccaaacct gatctggcct ccatgggtat gtccgctgag tatcacatca 2036101 ataccgtcat cttcattgat ttgttcatga atctccggat tatggcaaac cagaatattc 2036161 agctggcttt catcaagttc tttgatggct tcctcataat gatccatctc catcctgata 2036221 tcatcaaccc ccgcaatcgc aatcgtatgc ccattgtatg aaaacgggac tgactcattt 2036281 ctcagagtga tgacgccgtg cgctttaaat atggaataca gcttatgctg cctgacttca 2036341 taatcattat tcccccacac aaacacgata gggaccccga aatgtacgag ccttttgatg 2036401 ttttcctcga ttctcgcact gggcaccccg ccctcagcta aatcaccgcc gattataacc 2036461 aagtgggggg catggcttcg cgctttttct aaaaggtctt gatcgatgag acgtttgtga 2036521 atgtctgaaa taaaaaagat tgtcagaggc ggcttgccct tcatctttga taaaggaaac 2036581 gtatgtgtct tcaaatgatt gccttttgct gttgcataca tttttgccgt cattgccgct 2036641 gccgcaacag ttagtacacc ggcaattttc actgatagct tcataaaaaa ctctccattc 2036701 tttttagaac ttatcaataa gacggacaat aaaaaaagac gtttctatcg tttgagaaaa 2036761 cgccccattt tatttacttt caaaatatag attaatgtca tatttgtgct tcatcatatg 2036821 aaaaacagac tctctcgcct tccatttatc gggctgcggc cagagatcag tgcttttctg 2036881 aataatttca catctcagtt tatggaaatc agtctcggat ttttcttcct ttttcttgaa 2036941 ataatatgaa gtgcagtagg caaaagcggt tgccagcatc caaaataaat aaaaggtatg 2037001 gctaagtatt tcttgaagta taagctgagg ctccgggctt ttgatcatga tcataacaca 2037061 taataagcct aggcagataa gtgaagccca tcgccatctg cggcattgtg ctgcataatt 2037121 ttcgaatttt tgttttcgtt ttaccagcgc ttggagcatc tgtttggtcg gcgcgtctgt 2037181 aaactgatcc agctgattcc ataaggattc catacgcttc acaccttgtc cattttcatt 2037241 gctacaatat atgaacgtaa aataaaaata ataccctatt catccattaa agggatgtcc 2037301 aaaacttgtc cggtgtaaac atcatttcca ttcagatgat tatatgctcg aattttttct 2037361 tctcctgtcc ggcttttata atacttcatg gaaatgcggt atagcgtttc tttcttttgg 2037421 acggtgtgct tgacaacgcg attcggcaca ttttgaactg gctcagctgg ctgttcttgc 2037481 tgttgtactg ttgattggga agaggaagca gccgcggcgg ttgcttcctc cttatttggc 2037541 gagtcttctt tttccgctac agcagtctgt ttcttatcag cagctgtttg ctcttttggc 2037601 ttggaatctt ctggctcttt ttttgactcc ttctgcagtg cggtttcttt agtgtctgcg 2037661 gtatcgtttt tatcctctga tttcgggaca acctcatatt tgctttggct gctgtcaata 2037721 aaaacatctt cataatcgtc atgattatcc gggtggctct ttagataaaa taaggtgact 2037781 aaaacgataa ccggcacaaa tacaaatatt actgcgagta ctgtgaataa tggcgttttt 2037841 gttttgcctt gctttttttt ctgttctctt tgatttttta cagattgtct tgtcggaagg 2037901 ctttctccat catcgacata atcgtccgcc aatgcggcgt tttgatcttc ataaagattc 2037961 tgggcttttc ttctctctac tctcgacatg ttcgtcatgt ttatccctcc tcacatgttc 2038021 aaaacgaatc tgacaggcaa acacggcatc aatgataaaa tgcgccgtca tcggaacaaa 2038081 taagttgccg gtccattcat acatcagacc gagcaaaaag ctgattgctg tcaccataat 2038141 aaataacagc cattttgaca aataccgaaa gtgcagagcg gcaaatataa ggctggccgt 2038201 ccataaaccg atatgagtct gcagcactcc tctgaataac atttcttccg cgaaagcaat 2038261 cagaagcgtt aaaaatataa tatgagggat tgacctctta ctgaatattt ttttattgat 2038321 tccgccgtca tcatataaat gagacggaaa ccatttcatt actgccatat cggctaaaat 2038381 aacaataaca gctatagaaa caccatacca gatgattcgc atatcgcgaa tgtcccagag 2038441 ctttaatacg tcccgtacat cctcaaaaaa gaacagtcct gctgcagcag cggcaaagat 2038501 gatgagtagc tgcgtcaaat ataactgctt cagcatatca tggtcagtca tatgctgaat 2038561 ataatctttt tgctgtttca gttcagctca cctacagtct gcaagctgaa tatccggtgc 2038621 aattccgaac tccagctgtc taatggcgcc attttactcc gttccccttt ttgttcatac 2038681 aaggataaat caaaaccgca atgtgaacag cacgggaggt ttccgtcatc aggctcgtat 2038741 gattcatcaa agtaggttaa cagtgcctgc cttaaacagc cgtcacgctg aagcaaaaat 2038801 gatacacggt gcattttttc cagcttcagc tccatgcgat atgaaatttc tttcttcatc 2038861 agttcaactg atgtttttcc ctgcataaag agatgaatca tcatacgggc ctgtgtctct 2038921 ccgacgccat actgaagtaa tacgtcacgc agccttctct catcccgctc ctccgtcttc 2038981 tctagcacac ggattacgtc ggcgatttct tcagctgtga cactctccat ctggataatt 2039041 tgttcctgca attcaaaatc ccctggcgcc cgcagcaaaa tgctgacact cggctttccg 2039101 tcgcgtcccg ctctgccgat ttcctgcata aaagcttctg ccgtctgcgg gagatgaaaa 2039161 tgaatcacat atctgatatc aggtttatcg acacccattc caaacgcatt cgtacaacat 2039221 atcacatcaa gctggttatg aataaactgc tgctgaatta aaatcctgtc ccctgactcc 2039281 aaaccgccat ggtaaaagtc ggctctgctg ctcgttttgc ttttaatttc acccgctaat 2039341 tccttagccc atttccgtgt tggacaataa acaattcccg gaccttgcag gttttcaacc 2039401 agctgaatga ccctatctat tttttcggca gtatccgccg cattttcaac cctcagtgcg 2039461 atgtttgggc ggttgactga gttgagatgg cgtacagcat gctgcagctc cagcaggttc 2039521 atgacatctt gcagcgtttc ctttgtagcc gtggcggtca atgccagaac gggtgggtgt 2039581 ccaagttttt ttctcagctg tccgagcttt gaataatcag gcctgaagtc gtgtccccat 2039641 tcagaaatac aatgcgcttc gtcaataaca aataggctaa tcggaacgct tttcaatttt 2039701 tccaatacat atggagactg taaagcttca ggagacaagt acaaaaattt atatcgatga 2039761 atatgttcta aaacaaattg tctttcctgc ctgttaagca tgctgttcaa agctgcagca 2039821 cgcttttccc cccgggcttt gagctgctgc acctgatcct ccattaaaga aagcagtgga 2039881 gaaacgatta ataccatgcc atcaagcata taaccaggca gctggtagca aagcgatttc 2039941 cctcccccag tcgggagcat tgcaatggta tccttcccgc tgagtatgct ttcaataatg 2040001 tcctgctgcc cttttttaaa ggaagtaaaa ccaaaaaact gatataacgt ttgctgtaat 2040061 ttagtcatat tgctgcacct gctttgtcaa tgccagtctg atttgaaagt agctgaaccg 2040121 ctgttccagc ccgtcgcgaa tttgtttgat tttattcgtc cgcatccgtt tggcaaactc 2040181 tgcgatttga agctggtctt ctgctgatac atagtcatta atcataaacg caggctcatg 2040241 gagagaaatc tcgacaatgt ggtcttcaat cgtcgctgtt ttcagctttc tgatttcagc 2040301 aattcgctgt atcggaaacc cttgtttgac catctgccat gttttcctcg tcgactctgt 2040361 cagggcatta tctaagtgca catcagaaag gagatccttt aacaaagcat cttcacactc 2040421 cggaagagaa tgaataaaat aatgtaccga agcccaaaac atgatataga cataccattc 2040481 gtcttctttc agcgtatcag caagctgcct gctcgtataa ccgatccgat ggtgcgaggt 2040541 taaggagtag acaaaaattt gcgctgcttt gttttcaatc tttttcaaat gcgcctcaag 2040601 catggcaaaa aggctttttg ccatctctat atgatccgta tgccgggaca ggtatttctt 2040661 tacccagtga agtgtcttat gatcctttgt gacagggata tactgcctgc tcccttgctg 2040721 tttatgggat aggacctgca caagcagcga aagccttttc caaagcacgc cggcagcctg 2040781 ctgataatga gcgccgtgac aatgaacggg ccaaggccgc tcgctaaggg catgtctcaa 2040841 aactgctgcg ccgctggctg tcactttgta tgtatctgat tcagacattg gcgcgagata 2040901 tgaatgcttt tcaagcttgt caagcgacgc agaaatatcg cttctcgaac attttgccgc 2040961 cattccaaag tattttgcag tctgaaataa gccggcatct tgaatggtct gtgacgatct 2041021 cttgcctttg aataggtgaa aaacagcgct tcccgaccgt tccccgttta ttttgcaaag 2041081 acaatcgaga accataatat cgaagtaatt taatgacaac ctatccacct acattcttcc 2041141 tgacaaaaat cgttgatttg ctctttttat tttaacagat ttcaaacaga aatcgacgtt 2041201 taaagtcatc attaaggggg atgttatgta gataacccct tatgtgataa gcattctcaa 2041261 tcatttttct gttgaaatgt ggcagcaaca tcattacaat aagtaagagg aataggtgtt 2041321 aaattgatta aatataaaga ttgatccatt tgttccacca agaacaatct gggaggtttt 2041381 attcatggca aagtacacaa tcgtagacaa agatacatgt attgcatgcg gcgcttgcgg 2041441 agctgctgca ccagacattt acgattacga tgatgaaggc atcgcgttcg taacgcttga 2041501 tgaaaacaaa ggtgttgtcg aagttcctga ggtactggaa gaagatatga ttgacgcatt 2041561 tgaaggatgc cctactgatt ccatcaaagt ggcggatgag ccatttgaag gcgacccgct 2041621 taaatttgaa tagaagtaac taaaaaaagc tcccgaacgg gagctttttt atttaatgga 2041681 tatgtgcact tcgctgctgc tcaatccatg gcttaagctt gataaaaatt agtgagaata 2041741 caaccgtaat tacaatacct tttatcatgt taaacggcag gatacctgcg acgactgctg 2041801 tttttagcgc gctgtcggat aatgccggtg aatgtaaaaa ccacgtgtat gccggaagaa 2041861 tcagaacata atttaaaata ctcattaaaa tggtcatcgc tgcagttccc aaaagcaggc 2041921 tgacagccaa gccctttgct gagttgagtt ttttaaataa gaaagcagtc ggtaatataa 2041981 agagtgttcc tgcaataaaa ttcgcaactt gccctacagg aactccggcc atgcttccct 2042041 gaatgatata ctgaagaaca ttttttatcg cttctacggc aatacccgcc aaaggtccgt 2042101 aaatcagaat ggcaataatt gcgggaacgt cgctaaaatc gatttttaaa taatccggaa 2042161 gacccggaaa cgggaaattt aacagcatca aaacaaatgc aatgctgctc agcatgctga 2042221 ccacaactaa tttttttact ttcacttcat tctctccttt tcgatcacat cttactcgaa 2042281 aacggaaagg ttcttttcca gccaataaaa aaaccgcttc atatataaaa gcggggtttc 2042341 gaaaattagg ctaggcaaag aaacgtttga aaaattcaat ttcaaaacgc ttatgaacct 2042401 ccatcttctc ccatccagac tgtactgtcg gctccggaat ctcaccgaat cctgctgtaa 2042461 agacagctcg cgggcttaga gccattggct catcaccgcc ggtagggaat ttcaccctgc 2042521 cccgaagatt gatcatatga aatttaatta cattataaac gataactggt tggctgtata 2042581 gagaattgct tcaaattaaa tatattacct gcaagctgtc agatcattga tttattaggc 2042641 tttactttta tcctttactg cgtcaataca cgttgacact cttttgagaa tatgttaaat 2042701 tatcagatat ttagtttgtc aatttaggag gaaatctaac gatgtttcga gtattggtct 2042761 cagacaaaat gagcaacgac ggtttacagc cacttattga atcagacttt attgaaatcg 2042821 ttcaaaaaaa cgtagcagat gcagaagatg aattacatac ttttgatgct cttttggtgc 2042881 gaagcgcgac aaaagtaaca gaagaccttt tcaacaaaat gacttcttta aaaattgtcg 2042941 gaagagccgg tgtcggtgtc gataatatcg atattgatga ggctacgaaa cacggggtaa 2043001 tcgtgatcaa tgctccgaac ggcaacacca tttcgacagc tgagcataca tttgcaatga 2043061 tctcttcttt aatgagacac attccgcagg ctaatatctc agtgaaatcc agagagtgga 2043121 accgcacagc ttatgtcggt tcagagcttt atggaaaaac gcttggtatt gtaggattag 2043181 gccgaatcgg aagtgaaatt gcacagcgtg cgagagcgtt cggtatgact gtgcacgttt 2043241 ttgatccttt cttaacggaa gaaagagcga aaaaaatcgg cgtaaacagc cgtacatttg 2043301 aagaagtgct tgaaagtgcg gatatcatta ccgttcacac gcctttaaca aaagaaacaa 2043361 aaggcttatt gaataaagaa acgattgcaa aaacgaaaaa aggcgttcgc ttaattaact 2043421 gtgcgcgagg cggaattatc gatgaagcag cacttctcga agctttggaa aacgggcatg 2043481 ttgcgggagc agcgcttgac gttttcgaag tcgaaccgcc agttgacaac aaacttgttg 2043541 atcatccatt agtcattgcc actcctcact tgggagcatc aacgaaagaa gcacagctca 2043601 atgtcgccgc ccaagtgtca gaagaagttc tgcagttcgc aaaaggcctg cctgtcatgt 2043661 cagctatcaa cctgcctgcc atgacaaaag atgaatttgc taaaattaag ccttaccatc 2043721 aaattgcagg aaaaattggc agccttgtat cacagtgcat gaaagaacca gtacaggatg 2043781 ttgccattca atatgaaggc acaattgcta aacttgaaac atcgttcatt acaaaagccc 2043841 ttctgtcagg ctttttaaaa ccgcgcgtag actctactgt taatgaggtc aatgccgggg 2043901 gtgtcgcaaa agaacgcggc attagcttca gtgaaaaaat ttcctcttct gaatctggat 2043961 acgataactg catcagcgta aaagtgacag gagaccgcag cacctttact gtaacggcta 2044021 cgtatattcc tcatttcgga gaacgaattg tcgagatcaa tggatttaat attgattttt 2044081 atccgactgg tcacttggtg tatatccagc atcaagatac aacaggtgtc atcggccgag 2044141 taggacgtat tctcggagat aatgatatta acattgcaac tatgcaggtt ggccgtaagg 2044201 aaaaaggcgg agaagccatc atgatgcttt cctttgacag acatctggaa gataaaattg 2044261 tgaaagaact aacaaatgtc cctgatattg tgtctgtgaa gctcattgat ctgccataat 2044321 taaaaaaact caagctatat agcttgagtt tttttattgt tctatccccg tgtgttttta 2044381 tgcaaaatat ctaagacact ccttagctca gaaacaggaa tttggcctgg tgcggacgcc 2044441 tcttctccag ctccaaaagt acaagccgat ccaaaaacct caccgctcag cctgctgatg 2044501 agccctgttg cagccattga cattgtaata atggggcggt ctgcatatat tgttttcatt 2044561 gtatacgtcg catcaagcag tgttaggaga tctccagtat cattcggcat gacagccatt 2044621 tttggaatat gcgcgcctaa gtcctgcatt tttcgaagtc tggaaataat ttcatctttt 2044681 acaggtgttt tttcaaagtc gtgatttgac atcaccacat agacgttgtt ttcttccgcc 2044741 agcgatacta acgcttttac atttgcatct cctgaaaata attcgatgtc tatcagatcg 2044801 atgtcttttg tttggattgc cgattccagc aaagcaagat aggagctttc gtccatctcc 2044861 atgctcccgc cctctttgtg ggttctgaat gtaaatagaa atagcttgtc ttctaaagat 2044921 ttacgaagct tagaaatgag ctttgtgacc gcttctctgt cattcgcttt ttcaaatacg 2044981 tcgactctcc attcaacaat gtccggattc agtaatttta ctgcctctgc ttcattcaga 2045041 atttgttttt ccgtctttcc catcagcgga atgatgattt tcggcatccc ttccccgatg 2045101 gaaactcctt taatcgttaa cacgttcact cgtctcaaat cctttcaatc tttaccttgt 2045161 tttattatac acgtacaact tttttttgaa aatttctatt atatgaatag caactaaaaa 2045221 agagccttaa agggctcttt ttagtttaag gaaatcggat ttggagcagc tggcaccgga 2045281 attgcatctg atatgtcata tttgccgatt tttttcgttc tggtttccgt aaaggtcact 2045341 tctgtgaagc caaactcttt tgcagtcaaa agtagtccct caatcattaa aataccggca 2045401 atagaatcat caacttctga ctcctttgaa aagcggatat ataagtgttt ctgtttcttc 2045461 gttacagatt ggacagcacc cgcttgaata agaggtgtcg tatcttcttg gctgctcgat 2045521 tccatttcct taatcgcttc ttttactgta tcaaaagaat gatttgacgg aacgagaaag 2045581 tcttgtcctt gtttattttg gtacaagtag taggatcgtt ttgactgttt gggaatcgaa 2045641 atttccgtaa aagtgccata tgagccaatc cgaaccccag tctcattttg atccgataaa 2045701 aatttgactt tttcataagg actccatttt aaggattctt taagcaattt ttttaacagt 2045761 gtatcatctt ttatagaaaa tgccgtagct ggctgatgga ctcgtatact taattccttc 2045821 tgctttggtt tttcctttat ttctacttca tctatgaagg ttggaattgt aatggcatga 2045881 tcaaggatgc ccaattcact actttcaaac agcatatcct ggatcgtttg gtctgcattt 2045941 gttttttgaa tgctgacggg tatgattgca gatgtatcgg catcagcaac cgctacagtg 2046001 atgtaattgt cttgttcctt ttcaggaacg acaaacgatg tctgatccaa ggacgatgca 2046061 gcttttgggc tgtcttctgt ctcagttttc gttactgcgt tctcttggga cgcttctttt 2046121 tgttgaggct gtgcctgatc aaagaaatga ggagaaataa tgaaggcgat ataaaccgca 2046181 attgcagcgg cacacgcggg gccaatccac ctgacagcgg gcttattttt acgctttgcc 2046241 atcgtcagcc gcttgtaaat atcctgaggc gaacgatggt ctttaactgc cggaagttga 2046301 cttaacaact cctttatctg ttcttcgttc cattctgact tcatcatcca ttagctcctc 2046361 cctcaaaagc tccatatgtt tccgaagtac tttgagccct ctgtgttggg tcgtttttac 2046421 tttgctttcc gagaagcgca gagccttggc tgtttcctgt attgaatatc cctgaataaa 2046481 ccgcaagata atcacagctc tttgatcgat tgtacattga tcaagcgcag cataaatttc 2046541 ccggacattt tcatgttgaa ccgcaagttc gtccggcagc aattgctgat ccctgacatc 2046601 ctgtgtatcc cagtcaaatg taccgagtat acgctgtctg attgtttgct gtttacggaa 2046661 ccagtctatc gcaacatggc gtgcgataga caaaagccat gttttttcac tgcttcttcc 2046721 ttcaaacgta tgataagaat ttaatacccg gatataaacc tcttgaagaa ggtcttctgt 2046781 ctggttttta tcctttacca tataaaataa aaattggtac aaatcttgat gatatgtatc 2046841 atataataat tgaaaggttt cttccatttg aaacccctcc gttcactttt ttgtcgtatg 2046901 aatagcttga aaagttacat tacaactata ttacgagtaa ctggaatttg gaagggaatt 2046961 tatattaaca tatccttaaa ttttattaat gttggctatt aaaaaaacac ccgctcagtc 2047021 agcgggtgtt tcttatggaa caagattctt cggcaaattc agactcgatt ttaccgtttt 2047081 gtcggaatat aaaaagaaaa tgttgttcct ttatctattc ggctgtgcac agtaattgat 2047141 ccgttgtggg cttccacgat atttttaacg atagccagcc ctaacccggt tcctgctctg 2047201 ccccttgtcc gcgctttatc tgccttataa aaccgctcaa agataaatgg cagatcttct 2047261 tccggtatgc cagacccgga gtctttgata tcaattttca atccatcctt cacagaatgg 2047321 actgaaatgg agacactgcc gccggctgaa gtatgccgca gcgcgttatc aatcaaattg 2047381 gtaaatacct gctccatctt gtcttcatca aacataaatt cctcttctgt gagagaaatg 2047441 tcatgatcta aagcaatatt tttttctttc gcaacaccgg aaaacttccg aatgatcttt 2047501 tctaaaaact cattcacatt gattttttca taatgtaagc ctgtatggcc tgattccatt 2047561 cgggctaaat caagcaaatc attaactaaa cggcccattc ggagcgattc gtcataaatg 2047621 atttgggcaa tttctttccg gtcttcttca gagcttgcaa tgtcatcgac aattgcttca 2047681 ctgtatccct gaagcatgga gatcggtgtt ctcagctcat gactgacatt tgcgataaag 2047741 tcctcccgca gcttatcaag gcggcgttct tctgtcatgt cacgcagtac ggcaaccgct 2047801 cctctgacgt gcgattccgc ataaagcggc gacatcaaaa gcacccatga tctgccttga 2047861 agcgtcatct caatcatttg ttctttttca gtgctgacag cgttttgaaa cagctctttt 2047921 gcttcaggcg gaagattgtc gccttctttg atattcatgt tctgttcata ataccaagcc 2047981 tgaagaaaac gttcagccgg cgggttggtc acaagaatcg taccgtcaat attaatggta 2048041 ataaccccgt cagccatact gctcaaaatg ttagaaagct gctctttttc ttgattgagc 2048101 gcattgatat gaaagttaag ctgccggccc atttgattaa aagcggtcgc cagttcaccg 2048161 atttcatcct gagttaaaat cgggattttt gtatcgaact tgcccttcgc caaatcctgc 2048221 gcgccttctc tcatttttcg gagagggtac gtgaccctgc ttgataaaaa gaatgcgaaa 2048281 aatgtggtca gcacaatcgc aattccagcg gcaagaaaaa tatagcgggt cgtatgtttt 2048341 gttgtatctt taacggcaag caaagactgg gataaaaaga ccatgccttt ctttccgtct 2048401 ttttcatacg ggacacctac aatcaggcgt tcattatccg tgtctgtatc gctcagtccc 2048461 gtccgtttgc ttactttttt atggtctttg agagctttat ttaagtcttt gtcatgctgt 2048521 atttgctcaa ccgtaataga cgacaggcga tttttatcat tcggagaata ccagtggttc 2048581 ttctcatcct ggatgatggc aatgcttgtt aagttatcag cgagttccca agtgattgac 2048641 cttgccagtg cctggtcctc gtgattttct aggatgacag caactttatt cgcaagctgt 2048701 gttaaatcat tctcagcttc ttccacatgg tagttttcaa taaactccag caaaagaacc 2048761 gttaaaatga acaatacgat caagacgagt gaaaggatcg taaaccacag cttgcctact 2048821 acgcttttcc aaaatttcat tcagcgccga cctcaaattt ataacctaca ccccatacgg 2048881 tgacaatttt tttcgcagct tccggagata ccttgttcag cttctctctc aagcgtttga 2048941 cgtgagtgtc cactgtccgt aaatcaccaa aaaactcata ttgccacact tctttcagaa 2049001 gcttttcccg atcatacacc ttgtcaggcg ttttcgctaa gaaatataga agctcatact 2049061 cttttggcgt caggctcact tctgttccat cagctgttac gcggtgagca tcatggtcta 2049121 ttgacagatg tgaaaacacg agcacatttt tcgtcggtgt attggcattg aaataagagg 2049181 tttgggatgc tcttctcaaa agggccttta cacgcagcac gacttctctc gggctgaacg 2049241 gcttaacaat ataatcatct gttcccgctt caaacccctg cacccggttt gcttcttctc 2049301 cttttgcggt cagcataata atgggtgtcg cttttttttc acgaatttgc cggcacactt 2049361 caattccatc agtccccggc atcatcagat caagcaaaat taagtcataa ttggcttcaa 2049421 gccctttggc aatggcttca tcaccatttt cagcttcatc tatagcataa ttttcacgtt 2049481 caagatacat tcttaaaagg cggcgaattc tggcttcgtc atcaactact aatatttttg 2049541 tttcgttcgt ttggtccatg ttttccccct gctttccttc tgttactttc attttatcaa 2049601 atcgtgagaa agtttgagaa ctgtgtcgct ttcaaaggac tatgcataag aatgaagtcc 2049661 ggcaagcaca agatttacga atattaaatt aaacataata atagcaaaac cgattacggc 2049721 cagccatgct gacttctcac cgtgccagcc tcttgacagt cttaaatgca agtaagcggc 2049781 atagaacaaa aatgtgatca gcgcccatac ttccttaggg tcccagcccc aaaatctggt 2049841 ccacgcgagc tgagcccaaa tcattgcaaa gatcagcgcg ccgagtgtaa agatcggaaa 2049901 tccgattgat acggccctgt acccaacctc atccaccaga tcaagattga cgtttttcac 2049961 cagcggatgt aatagagcgc tgattctttt tctgatgatc agacggagag ccccatacaa 2050021 cacaagacct gctccaaatg accaaatgac agtgttcact tttctgcctg agaaaagcgc 2050081 gggaagatca acaagcggtt ccattcttcc ttcggtcaaa agctctccct gatgcggacc 2050141 gacaagcgcg ggcatttcgt acaccatcac gcttttttct ttacttttgt ccacccagtt 2050201 aaactccgct tcatagcctg caagacgaaa tgccgatgtg attgcaataa aggcgacggt 2050261 tgtgaccagg ataaacataa tcgcttcaag ccagaaggtc tttttgcttg gctttgtctg 2050321 gtctacatgc ttcaaaagaa agatgacacc agcgacaaag ctgatggcaa gtatagcttg 2050381 cccaagcgcg gccgttgtta cgtgaatata cagccagtta ctttggagcg aaggaattaa 2050441 aggcgagata tctgtcggaa acatgctggc gtaggcaatc agcaataaag caattgacag 2050501 cgtaaacagg cctaatgaag gcaatctata gagaaaataa agaatgataa acgccaaaac 2050561 aagcatcatg ccaaaagcgg tggtgaattc aaacatattg ctgacaggcg catggccgct 2050621 tgcagcccac cttgtgatga aatatcctag gtggcagaaa aaaccgacaa tagaaagggt 2050681 gattccaatg ttggcccatc ggtttggcct gcccttttta tctttattcc cgcgtatggc 2050741 cccgccgaag attgggacag cgattaaata cacaagaaag gccgcataaa gaaaatttcc 2050801 gctcagctct gccatgacat cactcccttt tcgcctattt ctgtgttttg attaattctt 2050861 tttggtccac cggttcagtc agtccggaat cagccaatat aaatgctaaa tccttcttca 2050921 ggccaaacca gtttttattg gtatgccctg ctaccataac tgcaccgtcc tgtgagtgca 2050981 gccaaattct tcgatgctgc cagtacatac cttgaatgac accgatcata aaaatggctc 2051041 cgccgacagc aagcacccag agtgtcagat cctttctgac tgtaagtcca gtaatgtttt 2051101 tcgtttcgac atggtcaaat ttcagcttgt atttattatt gcctgatcct tcgatggttt 2051161 cttggatggc gacaaagctc ttttcgcctt tcggtttgtc cggcgttatg atattaaaga 2051221 caaaagccgg attgttaggg atctttgttt ttgtgctcgg ctctccgtcc tgattaaaat 2051281 agaagtcagg caggtagctg gcgatttcca ccttgtaacc gttaccaaga tcatagactg 2051341 aatctggatc cagaaggttg atcttcaggc tcccaaagga tttttttgtt tttttatcaa 2051401 tcagctggaa caccatttgg tcaagctgat tctctttgta atccacctgg taaacggaaa 2051461 aagaatcaaa acgcagcggc tgattgacac ggatgtcttc ttctgttact ttttccagct 2051521 tcggcttctc gccataaaca atttttcctt ctctcttgta gagtacggca tcagtttgaa 2051581 agttctttgc cactctaccg tccccgactc tgtcaatggc atctgcaaat accttttttt 2051641 ccgttttgct gttataggtc tctacgctga attgattgtt tttcaaataa tattttccgt 2051701 ctgtacccgg aattgctgcg gtttcgcctt ctctgaccca aagcgtctca tcgacgtaca 2051761 tgccaggcac aaatctcagc atcgcaccaa tcagaaagat gatcaatcca atgtggttga 2051821 catacgggcc ccagcgggaa aagcgtcctt tttcagcaag aatgctgccc tctttttctc 2051881 tgattctata atgttttttc tttaatagag taactatctt ttctttcgat tccccgttca 2051941 gtacagtaac tgtttcactg aacaagcgct gccttcttaa aaaggccggg ctccttctga 2052001 caccttggtt ttttaacgct ctatacaacg gaatgacccg atcaaggctg caaatcacga 2052061 gtgaaatgcc gatcgaggca atgagcagca aataccacca agaaccatat aaatgatgaa 2052121 acccgagcaa ataataaagc tggccaaacg tgccgtactg ctccttgtaa taagtatcag 2052181 cctgtgcgcc cggaggcaga taggcttcct ggggaaaaat ggtgccgaac gctgatgcgg 2052241 caagggttat gacgataagc catattccca ccttaaccga ggaaaagaaa ttccaaattt 2052301 tgtcgatgat cgttttgtta taggtttgcg aacgtcttgc gcttccgtca tatctcatat 2052361 cagcgagcgg aggttgagtt tcctgaagag ctcttccgca cgattcgcat aaaacggttc 2052421 cgaccgggtt tatatgtccg cattcacatt tgacttgctt catcccgaag tctctccggg 2052481 ttttatgaga ttcatataat cgtgtatcat gctttctgtc atagtgccgg tcaccacctt 2052541 gacaactttt ccttccggat tgatcaaaaa ggttgtcgga agcggagata cgtcataggc 2052601 atcaagcact tggcgatctg tatccagaac aaccgggaaa ttgactccgt aggatttcat 2052661 aaaattatgt actgctatct ttgactcccc aacatttaca gcgacaattt caacaccttg 2052721 gcttttaaaa tgcttatatt ggtttgccat ataaggaaac tcttttttgc acggttcaca 2052781 ccatgtaccc cagaaattca aaaaaacacc tttccctttt aagtcactga gctcgatacg 2052841 tttcccattc gtatcctcta ggacaaaatt cggtgcgtcg gacccttcgg atatactctc 2052901 tttgccggca aatacagcgt tgtaaatggt atagccgagt gcgcagatta aaacgagaag 2052961 gatgccggtc cgaatgaata aacgcctttt tttcttcatt gtccactgcc cccttccccc 2053021 tattgcagat ccattcaatt atatcattgc acgttcattt cacatttctt actttttgaa 2053081 ggttatgtga aatttagaaa gcgtttttac cgtgatccgc cagtgctctg agccttttta 2053141 cttcgtgagg cgtaagctct ctggcatcgc ccgtgtgcag gcctcgcagg tttaaaaacg 2053201 cgtattcctc acgcttcagc ttgattacct catgtccgat cgcttcaaac atgcggcgca 2053261 cttgtctgtt gcgtccctca tggatcgtca gctgaataat gcttgtctgc tttttcttat 2053321 ccaaagacag cagcttcgct ttagcaggcg ctgttttgcc ttcctccagc ctaattccgc 2053381 gctccagctt tctgagcagc tctttaggcg ggattccttt caccttcgcc acgtatgttt 2053441 tgtctatttc atacttagga tgcattagct tattggcgaa ttcgccgtca ttggttaaaa 2053501 gcaaaagacc gctcgtatca tagtccagac gcccaatcgg ataaatgcgc tgcggaatat 2053561 ttttaaaaaa gtccgtcacc actttgcgtc ctttatcatc ttgcgctgcg gaaataacgc 2053621 ctcttggttt atataagaga aagtaaaccg gctcttcgcg ttcaaccttt aacccgttta 2053681 cctcaatctg atcagaaccg gtgaccttaa cacctagctc tgttactact ttgccattca 2053741 cctttacttt tccttcttta atcagctctt ctgcctttct gcgcgacgca actccggcat 2053801 gagcaatcac tttttgcagt ctttccatgt ctttcacctc aagtattatc ttactttttt 2053861 caaccttaac aaacaagctt tttcaaattc ctatgccaaa tctaaaaaaa acgccgtttt 2053921 caggcgctcc caaataataa cgtaacgatg atgatagatg caactacgcc gattaaatct 2053981 gcaagaagtc ccacctttaa tgcatcaccc atttttttaa tgccgactgc tccgaaatac 2054041 acagtcagta cgtaaagcgt tgtatctgta gatccctgca tgacggaagc cagcctgccg 2054101 ataaaggaat cgggcccgta tactgcaatt aaatcggtcg tcattccaag tgcggccgta 2054161 ccggagatcg ggcggatcag agcaagcggc actacttcag cagggatgcc gatagcggag 2054221 aaagccggtt ttaaaagatc cattataaaa tcaagcgcgc ctgatgatct gaaaacagtt 2054281 atagcgacaa gcattccgac taaatagggg ataatggaaa aggcaatttc tatcccctct 2054341 ttcccgcctt cgacaaacga ttcatatgtc ggaacctttt tgatcgttcc ataaagaaga 2054401 attccggcaa taatgattgg aatcatggct aaagacagcc agttgatgat ttccatccgc 2054461 tcaccttccc ttctttttgc ggcggtaata aaaataccga tcaatgataa tggcaccgat 2054521 tccggaaata agcgttgcca aaatgcttgg cccgacgata tctgtcggcg ttttggagga 2054581 ataagccatt cggacagcga tcaccgttgt cgggatgagt gtgatgcagg acgtattaac 2054641 agctaaaaaa gtaatcatcg accggcttgc ttccgatcgg tttccgttca gctttttcat 2054701 ttgttccatt gctttaatgc caagcggagt tgctgcattt ccgaggccga agaaattcgc 2054761 cataagatta gataaaatat agcccatcgc cgggtgatcc ggcggtatat cagggaacag 2054821 tttagatata aaaggtctgc acatccggct gaaaatatcc aaaagccctg actgctcggc 2054881 gattttcatt aagccaagcc agaaaacaag cacgctcatc aatccaaatg agatcgtaat 2054941 cgcttctttc gcacccttaa acacggcttc atttacatct tgcagagttc cgttgcacat 2055001 cgcaaaaacg agtccgatca cggttaaact gacccaaatt atattgacca ttttgctccg 2055061 cctgccgcat tcagaaagat tgatttaaac gtttcaaaaa attgtttctt cggtttttga 2055121 tgccgctcat tttcataata gatcggcact tttgcgatgg ttgcatcgtt gaacatgatc 2055181 tccatgtgcc ctacgatgtc agggattttc gaggcatctt tttcccatgc ttttttcggc 2055241 ttgagcagtg tggtattaat ttttacattt tctttttcct cttcggtcag caaataggtg 2055301 atatcacgtt tgataaaagc cttcgattca taaaatgtgc ctttcagctt tggaatatcc 2055361 cctttttttg caattaaata ggtttgataa tgctcaaaca catagttaaa catcttcata 2055421 tggtcatccc aatcattagg gtcattaatg gtgacggcta tcaggtcaat gccgtccttt 2055481 gaagccgtag agaccagtgt ccgttttgca agttttgtat agcctgtttt tcctcctgtg 2055541 ctgtacggat aaagcatggt cagcagtttg tttttgtttt tccatacgct ttccatcgtt 2055601 tccgctttgt atatttttgt gcctgaaatc ttttgatagt ctttcagctt catagcatac 2055661 ttagttaaaa tggccatgtc ataggctgtt gaataatgat tttcatggtc gtccaatccg 2055721 tgcgggtttt gaaaacgggt gtttttcata ccaagctgct cggctttttg attcatcata 2055781 taaacaaacc catcgaggct cccaccgaca tgctcagcaa tcgcgacagc ggcatcgttt 2055841 cctgatctta gcatcaggcc atacacaaga tctttcagct tcactttttg accttctgtt 2055901 aaataaatgg cggagccttc tgttctgaca gcatttgccg aaaccgtcac tgtttgatcc 2055961 attttgccgg attcgatggc gaggacggcg gtcataattt ttgtgatgct cgcgatccgc 2056021 cttttttgat gctcatcctt ggcatataac actctgcctg acgcaccgtc aataatgatc 2056081 gcgctttttg cactgacatc tatagcagca tgtgctgtat tcacatttac ggttgcaata 2056141 agaaaagaaa tcatgatcac gaatactgct tttttgaaaa tgcgcatgtt tgctcacgtc 2056201 cttgtggtgg tttgtacaag tttatgcgca tgtccatcag ttatgaataa caattatatt 2056261 tctggaagca aacataaaaa aactctccct gaaaaaggga gagtaaacgt tatctgattg 2056321 gcgccatgct tgatccggac gcttcgtaat gagccagctc ttccctcatc ttcagaaagg 2056381 ccgcgctcaa cggcaataat aattgctcaa gcgacgcagg aacagcatga taaaactcaa 2056441 ttgcgctgac cccggtataa gacgcccggc tattttcaca ccacgtgtct tttttcggca 2056501 taaagaactc ttcaatgcat tggtgataca cattataaag tgttttttcc gctctggctt 2056561 cctgaaaagg ctcctgcatc aggagacgac ggcacgcttc tgcgcctcct tcacaaaata 2056621 ctgccattct tctcagagtg ctaagcacat cacagcagta tcctttttca ataggcaatt 2056681 cagcctgtaa ggactcaagc gtcgtttgat ttaggtaatc gttcacggta ttgacaacca 2056741 ttgataagaa ttcgcctgtt ttttgagtct gcgctcgcac aatcgaatgt cccatttcgt 2056801 ttggtatctt cccctcatgt atttgtctct cacattttgc ttctttcatg atagcttctt 2056861 ccttatatct tatgatgatg aaaaagcgcg attcattaaa cttctatttt atatcttcga 2056921 aggtttggtt aaagttttca aaaaataaat ctgcttcttc ttgaagaacg tcttcttccg 2056981 cattttcagg cagcggcgga agctcgtcca gcgttttcag accgaattgt tcaagaaaag 2057041 tcggcgtagt accgtataaa atggcccgcc ccggaccatc ggcacgccct acttcacaca 2057101 atagcgcctt cgcgacaaga ctgtgtaaaa tccgctctga ttttactcct ctgatttctt 2057161 caatttctgc tctcgtaatt ggctgtttgt atgaaacaat ggccagtact tctaaagatg 2057221 cttgagaaag gccctttgac ggcacttcaa tcagtttttt caagtaaggc gcaaagtctt 2057281 ttttggtaga gagcatgtac gtatctgcat actcaataag ttcaatccct cgtgtatctc 2057341 cgcggtattc gtccgccaca tccgccatga tcgtgttcag ttcaggctct tcgatttcaa 2057401 gcactgttaa cagctgcttt tttgtaagcc cttcatcgcc tgccgcataa agaagggctt 2057461 ccacaatagc tttccaattc acgatatcaa gccccatgaa tggattcact ccccgtaatg 2057521 taaatatctg aaaaattgtg ctcctgttca atgaggacca gctgattttt catcagctca 2057581 agaacagcta gaaaggtcac tactaaatgt tctttttgct catatggaaa cagatccata 2057641 aagttaattc tcgttcctct agatttcaag ctgtgcacga tttcgttcat tctggcttcg 2057701 attggtatgt cctgtcttgt aattgttgtt tccatcggcc tgtttatttt tttgcgtttc 2057761 agcacttttt gaaaagctcc gatcatatca tagaccgtga cagagagctt ttgctcagac 2057821 tgttttactt cttttgcata ttcactcaaa tcactcggcg gtttcgtgaa cgatttttgt 2057881 ctttcttctt cccgttcttt taaatccttc gccgcatctt tatattttcg gtactcaatc 2057941 agcttttcaa tcagttcctc ccgcggatct tcttcttcaa gtaattcatc ttcaaaaagc 2058001 tcctcctctt gcttcgggag cagcattctg cttttaatgc tgagcagcgt ggcagccata 2058061 accaaatact cgctggcaat gtcgagctca agcacgcgca tcgtatgtac atataataaa 2058121 tattgttcag tgatcttcgc cacaggtata tcatatatgt caatttcaag acgattgatt 2058181 aaatgaagca gcaggtccaa tgggccctca aacgtatcaa ttttcacttg atattcttcc 2058241 atcatctcac cattttcaag tatcactctc attgccggaa aaactggcta ccctatagta 2058301 taagccacca aaaagctctc gtccaatact atttcatatc ctgttttgaa ggagtttgta 2058361 cagaatattc aaaacacaag aggtgtttgc tcggagcgca gaagcgggag aaaaagcctt 2058421 tgcttctggt tttcctttct aagaagcact agaggccggg cgttcttttt tccttttatc 2058481 ccttctatgg tacactaaaa gcacattaaa ggaggaagca ccttgtatcc gaaagcttat 2058541 atagattatc tcgttgagtt tcatgcgaca cgggattatt ttgaatgcca tgaaatatta 2058601 gaagaatatt ggaaggaaga tccgccaaag aaacgaaaac gctattgggt gggctttatt 2058661 cagcttgcag tggctttata tcatcacaga aggcagaata cagccggggc aaaaagactg 2058721 atggcgaaca gcatccggat tcttcaagca gaacaccggg cagtcgaaga cttagggctt 2058781 gatcatggcc gtttgctcga acttatgcaa tcggtttacg aacaaatcga aaccgtctct 2058841 gcctataaaa gcattatact gccaatcaaa gatgagaaac tggaggaagc atgcaggatc 2058901 gaatgcagga aaaaaaagta tacatggggg cagcccagtg cactcagcaa catatttctt 2058961 atcgacaaac accgtttgcg ggatcggact gacgtcatcc gtgaacgtga aaaagaaata 2059021 gaacgcagaa aaaaaagcag agactgatca cagcctctgc ttaattattg tatgaaatgt 2059081 cttgatcctg ctgaccttga caacgttcga aaaagctctg cgttaattca tttggaacca 2059141 gtacttgcgt tttgaataaa tgctttaaag catccatcat ctgttttccg attccttgat 2059201 ggcgatgaga aggattcaca ctgatatgcc ggatctcaac ctcagaatcc tttttttcga 2059261 ctccgattgc tccgacgata tcctcgtcct ctttccaaag aaagagctgg cggtctgtat 2059321 ccgtttcgta gtccttaatt gtctgctgaa gctgcttaag gtctttttca ttcggcataa 2059381 acgaaagaag ccccatcgca atcttttcaa acgatttttt ataacgaatt aacataaaaa 2059441 cccctctata tccaaaatgt ccagtctgct attaacggat acgaataggt gatccgtttt 2059501 ctcacattat atcattttcg ccatattttt aaactgtttt cagcaaatta ttcaaatgag 2059561 cggtttaaat ttgccatttc aatggcagaa acagcacaat ctacaccttt gttgcccgct 2059621 tttgtgccgg cacgctcgat agcctgttcg atgttttcag ttgttacaat tccaaagatg 2059681 acaggtacac cagtagtgtt tgctgcttgc gcgatgcctt ttgcagcttc attgcagaca 2059741 taatcgtaat gtgtcgttgc gcctctgatg acagtgccca atgtgataat agcatcatat 2059801 ttttttgttt ccgccatttt tttcgcagca aacggtattt caaatgcgcc tggaacccaa 2059861 gccacatcaa tgtcatttgt gtctacgcca tgtctgagca gcgcatcttc tgctccgctc 2059921 agcagcttgc tcgtaataaa atcattaaat cttcctacta cgattccgat tttaagacct 2059981 gtaccaacta aatttccttg tatgatattc atatgattcc catccttttt tgtgatattt 2060041 gtgattagaa atgaagtaaa tgacctagct tgttcatttt ggtttgcaaa tattttttat 2060101 tgtgttcttt cgcctccatt tgaagcggca ctctttctga aatactgagt ccgtagcctt 2060161 caaggcctgc gatttttcgc ggattattcg tcaaaagctt catattccgg acaccgaggt 2060221 cgcgtaaaat ttgtgctccg atgccatagt tgcgaagatc cggcaagaat ccaagcgcct 2060281 cattggcttc tacggtgtca tagccttgtt cctgaagctt ataagctttt aatttattga 2060341 ttaaaccgat gcctcgtcct tcttggcgca agtacaggag cactccacgg ccttctgcgg 2060401 caatttggtt cagcgcggcg tgcagctgcg gtccgcaatc acagcgatga gagccaaaca 2060461 cgtcacctgt gagacattct gaatgcaccc ggaccaatac cggttcttct ccgaacggca 2060521 catctcccat cacaaatgcg acatgctctt ttccatctac ctcatttgtg tatccataaa 2060581 ccttaaatgt cccaaaatca gtaggcagcg taatgtcaac ttcacgctcg acaagtgttg 2060641 tcagattgta acggtattga atcaaatcct taatggtgat catttttaat tgatgctttt 2060701 tcgcaatttc aatgagctca ggcactctcg ccatcgttcc gtcttcattc ataatttcac 2060761 aaatgacgcc ggctcctgga gatccgcaag cttcagcaag atcaacagca gcttctgtat 2060821 ggcccgctct tttcaggaca cctccttttt tcgcaatcag tggaaaaatg tgccccggac 2060881 gctgaaaatc agatggcacg gatttgctgt ccagcaatgc ttgaacggta aaagatcttt 2060941 cttgagcgct gatacctgtc ttcgtttcac gatggtctat gcttacggta aatgcagtgt 2061001 ggtgagagtc tgtattatgc tcaaccatag ggtgaagatc aagcctgtct gcgatttcct 2061061 cactgagcgg cgtgcagatc agtcctctcc catgtgtcgc cataaagtta atgacttccg 2061121 gcgttgcatg ctcggcaaga gccacaaagt ctccttcatt ttctctgtct tcatcatcta 2061181 caacgatgat gacttcgcct ttttttaaag cgtccagtgc ttcttctatc ggatgaaaca 2061241 tgcaaatctt cctctctaaa agccgttttc gcttaagaag gcttttgtaa tggtttgttg 2061301 ggtcttattt tcattggctt tatgcaaaaa tcgatacata tattttccga tcatatcgca 2061361 ttcgatattc actttagagc cgatcgtttt ttctgaaaag atcgtttcgc tgatcgtatg 2061421 cggtattaag gagatcgtca ctgtgtcttc tgtcaggccg aatatggtta agctcacgcc 2061481 atccacagta attgatccct ttaaaaccaa tgtttttgtt aatgacgggt ccatttttaa 2061541 atcatagtaa actgcgttgc ttttctcttc aattcgtgtg atttccgcag ttccgtcgac 2061601 atggcctgag acgaaatggc ctccgaaacg gccgtttgcc gccatcgctc tttccagatt 2061661 tactttgctt ccttttgtta aatcattcag tgacgtagct ttgactgttt caggcataac 2061721 atccactgtg aattgatttt ttgtaaaatc agtgacagtc agacaaatgc cgttcactgc 2061781 aatgctgtcg ccaagatgaa catcctctaa aatctttgag catttaatag ttaaggccat 2061841 tgcatgccct gcttttttca tggattcgat tgtgcctgtt tcttcgataa ttcctgtaaa 2061901 catggtcacc atcctattcc tttgtcggtt ttgccgtcag tttgatatca cggccgattt 2061961 gggttatatc agtgaattgt aataagggga catctttcat tgattgaaaa ccttcaccgg 2062021 agattaagct gggagcatgc gttcctccga ttagtttagg ggcaaaatag aagatgattt 2062081 cttgaaaaca gccttctttg acaaagcttc cgtgaacagc tgaaccgcct tccacataca 2062141 ccgacatgat gccttcttcc gctaggatct tcaaaacatc aggaatttga atgcgctcgg 2062201 tttcaagtgt aaatatgttc actccgaaag ctgaaagccg ttttttcttt tcctcgtctg 2062261 cgcgtgccgt cgtaaaaatc catgtcggcg ctatttgatc gcaaatcact ttagcgtcct 2062321 caggaatcga gagtacggta tcaagtatga cccgaaccgg ctgttttgtt acattcggca 2062381 gtctgcaggt taagctcgga ttgtcggctt tcactgtgcc aactccgact aaaatgcttt 2062441 ggtgtgtttt cctgtattgc tgagcatcct gtcttgcagc ctctgacgtg atccatttgc 2062501 tgtcacccgt gctggtagct atcttgccgt caaggctggc agccgctttt agcgtgacgt 2062561 acggaaggcc tgtcctcata aagtgcagaa atttttcatt cagcctctcc gcctggtctg 2062621 ccaggatgcc ttcccttacc tcaatgccag cttctttcat catgctgatc cctcttccag 2062681 ccacaagcgg attaggatct ctcatcgcca cgaacactct tttgatacca gagttgataa 2062741 tcaattctgc acatggcggt gtttttccgt aatggctgca cggttcgagt gtaacgtaaa 2062801 tgtcggcacc ctctgcatgt gctccagcca tatggatggc atgaacttct gcatgagctt 2062861 caccatattt taaatgggcg cccattccga caatttgtcc gtcctttacg acaacagcgc 2062921 cgacgagcgg attggattcg gtctgtcctt cgccctgctt cgcaagatct aaggccagct 2062981 tcatataata ctcttccatt tgtttccctc ccctcttttg ttatttaccg tcaaaaaagc 2063041 cccgaattta taaaaaattc ggggctttag gtattttacg caataggaaa taacactatg 2063101 catttttaaa cattttgcat agcggctcat catccttctc ccatccagac tttcactgtc 2063161 ggcttcagct taaactgaat ccaccgcgtg cttatgcaca cgggtcacgg gctctaaagc 2063221 aaatgtgctt tactaccgcc ggtcgggatt tccaccctgc cccgaaggat acaatcttta 2063281 ttcatttgtc cttattggtt attatagcga tcctttttaa agtacgcaat gaaataaact 2063341 tacaatttga gaaaaacaaa acatcaccct tcgatccgaa aggtgatgtt ttttaatcat 2063401 tcacttttgc aaccttgatt aatccgtcga tccgctttga tttgctgaag taagccttaa 2063461 tcttgtcacc ttcttttata tcagataaat cctgatttaa tttttttccg ttgaagatga 2063521 ttttcgttcc gttttctgct actccatgat actctgagcc gtcaattttc gtcactttat 2063581 attcctggat ggtgtattcc tcttcttccg aggacaaggt ttgtccaatt gctgtcggaa 2063641 catccttcag ctcaatatca tttatgtaca tataaccgcc tgcaagtaaa agcaaaagca 2063701 ctaacagaat ggtaatcttg gtttttattc ttcccatttc taaacctcca gccaatatga 2063761 atctattcat tcatatgagt tattcctttt tttcatgaat aaaaaaccgt aaattctcgt 2063821 aaattattaa tataacgatg cataacggga atatgtttca catttctgca aaaatttctt 2063881 ttctatagat atacgaattt atgttctgtt tttaggggat gaccgtaaaa aagatataaa 2063941 aaaagcagcc ccaatgggaa gctgcttgat cctaatttgt tttgcgcatt tcgttaaacg 2064001 ggtagaaaac aaactttgac gtacccgcaa tttgtttttt cgtgaagagg ccaaggccgt 2064061 tacggctgtc catggaattg cgacgattgt cacccatcac aaaatacttg ttatcaggca 2064121 ctttaaccgg gccgaaatca tcggtcaaat ggtcaaaacc gtcctgtttc gctctctttt 2064181 tattagccgc caaataaggt tcgtccacct ttttcccgtt gatatagagc tggtcatttt 2064241 tcatctcaac cgtatcgccg ggaaggccga taatacgttt gacatagtga acatcatctc 2064301 cgtttaacac gacgatgtct cctctatcaa actcgccgat gtatttgact gtcatattaa 2064361 caaaaaccct ttcacggttg tgaagtgtag gatacataga gtcaccatca acgacatacg 2064421 gcgcaaaaat aaagttgcgg atgagcaaag caagaacgac agcaatcaca attgcttttg 2064481 cccattctaa tattgacttt ttcttcgaaa cattttctga tttcaactga tttcctccaa 2064541 taaacaacgg tcttcaattt atgttatcac gaatcgaaaa aaaatcccat taggaccatt 2064601 gaagtgattt tacaaactgt taatcttcat cttctaccca catcatgcct attttttctt 2064661 gtcgatcata actaggcctg aaaatattga aagaaatgaa tcgcataatt cagaagcgat 2064721 ggactcagaa gaaagagagt tctcatatgc aaaatcttta gatcgtatat aaagcatgag 2064781 gttacgggca gtttgttcat ttactgcatt ccattgatct cccagtccat gatacccatg 2064841 gcacttgaca aaacaattaa cgtcatgaag gttactggaa tgtttgcggc aacctatttc 2064901 acaggtgata accgcacccc gttttttgct ttcataatat gtttaaaatc attcaagctc 2064961 gaaaacatgg atcagcctcc aaaaaataaa tccaatatat tcccggcagt tgaagactct 2065021 ttattataaa actctgaata tccgcagttc ttacagtaaa ccactagaaa tcggttatgc 2065081 tgcacgtcaa acagctttga taatcccgtg ccggttgtag ctatttcttt ttgtccggct 2065141 tcagtactac cgcattttat acagcctttg ttgttcatat cgcgatctcc ttttcattac 2065201 atcacgtttg tttgatttat tttactacaa aatatcaatc ccaatgaccc gtactacttt 2065261 aaagtttact taattttgat tacatactaa ttgggttcgt ttctcagctt ggtaaatctt 2065321 ctggagaaac ggaaaagctc catgaccaaa acattcaaac tcagccaaac accgccgaag 2065381 gcgtaacccg cagcaacatc actcggatac tgctcataaa gtacacacgg ctcagcccga 2065441 tgaggaataa aacgataata aacaaaaaaa tgcaacagtt tgcagacgcg tcttgtgaga 2065501 atgacgaaca aaaagataag cacaaaaacc aaaaatgaca aatgccgtta aagtctgttc 2065561 gctcgggaat ggatataata catgactttc caaaggagcg tgaacaggat gaagggaatg 2065621 aaagagccgt ctgattccct cttcataaag ctccccacca atgactagga aaaataagaa 2065681 agagagttcg attttccgat cttgccctct gaataccgtc caaaaaaaag ttagaacaat 2065741 aacggctaac agaacacctc tcgacgcaaa agctttctga attgcagctg ggcccagtct 2065801 atacccgatc caatacgaca tgctcactcc cacagctccc caatccggcc gctaacatgc 2065861 ttagcaccca gtttaacttt tcttgaaaca cgagaacacc ggcaaactct cccggtccaa 2065921 gtaaagctag aagctctaac atcaagacaa taaacaagac ggcatatccg tactgttcga 2065981 gcaaccccgt caaaacttgc atgtgattct ccttaaactt ttttgttctt ttatcattcc 2066041 caatccactt tttgtataat cagcacaatt ttatcttcag tcgtccaaca acattgtcta 2066101 tggcgggatc ttctctcata cattcttttt tgacatagga ggagcaatag catgaaatgg 2066161 gaggaaacaa aagatacgca gggagtttgc caaaattttg ggcagttcgt tctgccaccg 2066221 agtcaggtgt ttgtttgccc acctcatccc ttgtcaattc cccatttttc ccgtttgagg 2066281 ttcgaaatgg taaagtattt cacttagttt cttacatgaa gaggtaaatt ctttgctcac 2066341 cgaactagga tagcggcgta tggcgatttc tacattgcat aaccactggt tatttagtga 2066401 gccgtgagca atgtatatgc actttgagtc agcacaggat gatcctatta cattcgccag 2066461 aaaagcagct gccgcattca gagtagttaa aagaatagac agatatctgg gcttccggaa 2066521 gctttaaagg aggctctttt ttcgagcatt tttataaatc aataaaaaca ggcatctcct 2066581 aaatattttt gccgataagt ttacgctaat caactctagc actaatacat ataaaaaata 2066641 gaatgatatg aaaggagact tgatagtatg attgattatc ctattaatat aaacaacgtt 2066701 tccgggaaca gtgtaattaa cgtaggcggc gcttttatga tcaggccttt aactttgtcc 2066761 aaatctgtgt ttggctccgg aggtttaaac acaggaattg tctttgaaaa taactttgta 2066821 agcaaagcta aaatgattaa tcatcaattt actgatcaaa acgtcaccaa aactttttaa 2066881 tgtattcaat acacgggggt cactaactaa acacctggtt ttgccaaccg ccatcagcat 2066941 tcggcggttt tttattgaac atttttggcc aataaaaaaa gcttcctctc taagaggaag 2067001 ccttttgcct gccgattagc cttctacacg aacttctttc atgacatcgc cattagacat 2067061 gtttttcgcg aattctaatc cgcttgttac tttaccaaat acagtgtgaa caccgttcaa 2067121 atgaggctgt ggctcatgaa cgatgaaaaa ttggctgccg ccagtgtctt ttccggcatg 2067181 tgccatagaa agtgcgcccg cctcatgtgt atgcgggttg ccttctgttt cacatttgat 2067241 tgtgtatccc ggaccgcctg taccagttcc gtgcgggcat ccgccttggc tgacgaagcc 2067301 agggatcact cggtggaatg taagcccgtc ataaaagcct tcgttcgcaa gcttttcaaa 2067361 gtttgcaaca gttccaggtg cagcttcagg ataaagttca aattcaattt tgttcccgtc 2067421 ttctaataaa aagtaacctg ttttcaattg tatgcctact ttctttattt taattttcaa 2067481 aggagattat gtataggtta tagcctgtct ctccttgtcg cggctattat accacacctt 2067541 tcgggggaaa acgaatctcc cgagctttac taaaaaataa aaatgaaacc tgaatctctt 2067601 tatctccgtc taacctaacg gaactgtatt tttcatgatt caggtcctca caaagcagca 2067661 ctatccagct gcttgtgaaa ttgaaggagg tcaaactgct ttgaagaaaa tttggattgg 2067721 aatgctggca gcggccgttt tgctgctgat ggttccgaag gtcagtctcg cggatgccgc 2067781 agttggagat gtcattgtaa cactgggtgc tgatttgtca gaatctgaca aacaaaaagt 2067841 gcttgatgaa atgaatgtcc ctgataatgc cacaacggta accgtgacca ataaggaaga 2067901 acatgaatat ttaggaaaat atatatcgaa cgcgcaaatc ggatcgagag cgatttcttc 2067961 atcgtcaatc accattgcca aaaaaggctc cggattgaat gttgagaccc ataatatcag 2068021 cggcatcaca gatgaaatgt acctgaatgc actgatgaca gccggtgtta aagatgcgaa 2068081 ggtgtatgtt acagcaccgt ttgaagtatc cgggactgcc gctttaactg gattgattaa 2068141 ggcgtatgaa gtttcttctg acgaagcgat ctcggaggat gttaagcagg tcgccaacca 2068201 agagcttgtc acgacatcag agcttggaga caaaatcggt aacgaaaatg cggcagccct 2068261 gattgcaaaa atcaaagaag agtttgctaa aaacggggtg cctgataata aagctgacat 2068321 cgaaaaacaa gtggatgacg cagcttctga tttaaacgtc acacttacag acagccaaaa 2068381 gaatcagctt gtctccctat tcaataagat gaaaaacgct gacattgact ggggacaggt 2068441 cagtgaccag ctagataaag cgaaagataa gattacgaaa ttcatagaat cagatgaagg 2068501 caaaaacttc atccagaaag tcattgattt cttcgtatct atctggaatg cgattgtatc 2068561 tatattcaaa taagaaaagc gccgaaaaat cggcgctttc ttttattgct ttacacccgt 2068621 tttaaatggc agatcaagtt ttacaatatc ttcgtatgtt tctcgcttca cgactaaatg 2068681 agcctcaccg ttttcgacaa atacaacggc gggtctcgga atacggttat aattgttggc 2068741 catgctgtat ccataagcgc ctgtacaaaa aacggcaaga agatcgcctt cttttacttc 2068801 cggcaggtca atatcccaaa tcagcatatc tccgctttca cagcactttc cggcaattga 2068861 taccgttttg tcatgcgctt ctccgatcct gttggctgcc gcagcttcat atttagcttg 2068921 gtaaagcgca ggacgaatat tgtcgttcat gcctccgtct acagccacat attggcggac 2068981 acccggcact tctttttgag agccaaccgt ataaagagtt gtgcctgcgt ctcccacgag 2069041 agaacggccc ggttcgatcc aaatttccgg aatgtcaaaa ccgtaacggg aagcattttc 2069101 tttcacagct tcgataattt tttcaacgta ttcagtggca tgaagcggtt catcatcttc 2069161 cgtataacga atgccgaaac ctcctccaag attcagcacc ttggatacaa atgaatatga 2069221 atctctccat tcgtctagtt ttttgaagat tttttccgct gctaacacaa aaccggccgt 2069281 atcaaagatt tgcgagccga tatggcaatg gacacccagc agctgaatgt gttccgattg 2069341 taatacttgt tcaatggccc gttcagtttg tccgttatga agatcgaaac caaactttga 2069401 atcttcctgg cccgttgtaa tgtagtcatg cgtatgcgct tctactccgg gcgtgatccg 2069461 aagaagaaca tcgatggagt gacccgtttc tttacatagg tcttcaagaa gcgcgatttc 2069521 atagaaatta tccaccacaa tgcagccgat gcggtgctca agcgccatcc gcagttcttc 2069581 cctgctctta ttgtttccat gaaagtggat gcgttctgcc ggaaagcctg ctgcaacagc 2069641 cgtatatagc tctcctccgg atacgacatc taaagaaagt ccctcttcct cagcgagctg 2069701 aatcattgcg actgatgaga atgctttgct cgcatatgcc acctgtgctt tcagccctgc 2069761 agaaataaac gcctgcttaa agcttttagc acgctcacgt attaaagcca catcatatac 2069821 gtaaagaggt gtaccatatt tctccgctaa atagagagca tccacacctc cgatttctaa 2069881 atgaccatgt tgattttgtc tgcttgtgcc gtgtaagaac aatgtcattc cctctttctc 2069941 cgcttatgga tgaaaggaca gttttatgga ctgtcccttc ataattaaga catacattat 2070001 catactcttc agtcagtttc aatgcgatta tgaattggta ggctgcctta agcgattttt 2070061 ggggtgaacg atgctgggtc ttacttttgc gccaggtttc gctgtgcgga caagaacctg 2070121 ccacagcgcc tttccgttaa agggaatcag cggccataag tacggtgtct gaagggattt 2070181 gatgcttgcc atggcaataa ttagcactgt aaatccgatg acgagccctt ttatatgaaa 2070241 taaagcaacg agtatcatga ggacaagacg gctcattttg tttgccaagc ttaattcata 2070301 actaggcgtc gtaaaggttc caatcgccgc aagtgagacg tacagaatca cctcaggaga 2070361 aaaaaggccg acctcaatcg caatctgccc gatcagaaca gcggcaatta aacccattgc 2070421 tgtcgataaa gccgtcggtg tgtgaatggc agccattctg agaaactcga ttcctaagtc 2070481 agctaaaaat atctgcagga tgatcgggat atgcgtatct ttatttaaac cgataaattt 2070541 catgttgtcc gggagcagat caggctgaag cacaaagaga aaccagatcg gaagaaataa 2070601 agtagaagca agaataccga aaaatcttac ccatcttaaa aaggtcccga ctgaaggcgc 2070661 ctgcctatat tcttcagcat gctgcacatg gtgaaataaa gtcgtcgggg taatgatcac 2070721 actcggcgat gtgtccacta taatgataac atggccttct agaacatgat ttgcggccac 2070781 atccggtctt tctgtatagc gcacgagcgg aaaaggatta tagctttgat taacaatgaa 2070841 ttcctcgaca gttttgtctg ccattgttaa tccatcgaca tcaatggatg caatttcttt 2070901 ttctacgatc tcaaccagat ccggatcagc tatatcttct atataacaaa tgcttaaatc 2070961 cgtctttgac cgctcaccaa ctttagtcat cttgactcga aggcgttcgt ctctgatccg 2071021 ccttctgaga agggccgtat tgacgacgat attttcaaca aatccgtctc tggctcccct 2071081 gaccaccttt tccgtatcag gttcttccgg gtttctgccc ggatagcttc tgacatcaat 2071141 tataaatgcg aagcctgcac cttcaacaat gacagcgacg agcccggaca gcacttggtc 2071201 ggtggtttca tccaaggttt ttactttttc gacctgggcg ttaagcagcc tgttttcgac 2071261 gatgtcgacc agctcatcag ggtcttcttt ccgattgtta atggcaacaa gctctctcat 2071321 taaatgaata atataggctg tatcgcataa tccatttaga tagtaaagct ggatctcttt 2071381 atctaaaatc gtgagcttgc gaacacctac atcatagctc gtccccatcc caacacggtt 2071441 tttgaaatac tcttcatttt tagctggatt ccgataaacc cgaattttct cttccttgtg 2071501 gtccggcatg atacccgctc ctttctaaaa taaactcgac cgctttcatg gtgattggcg 2071561 acccttttga gatatcgtct tttctgccca ttttgccgat atccccgata ccgacaataa 2071621 gcgggagatc aagtttatca aggcaataga ctgtatctcc actcattctg tggtcatcaa 2071681 attccctttc cccgacttta tcgacgccgt attcagttat ttctccattg cggtcaatgc 2071741 ttacatcgac cctggtccat tcagcctgat gtgtttttga cgcgaccgca atcacaccga 2071801 gcacttcaat agacggatgg gttgcgacat aggttagagc ggcttctccc gggccctctc 2071861 cttgaaggcc ggagtcgtca aacatgacaa atacaggatc atacggtgct gaggcgatca 2071921 gcttgacaag ctcggcgccg ctgcgggtgg aaggattccc ttttgattgt gaaatacatc 2071981 ggcctcccac tttgcttgcg gcgtattcaa ttgttttagc ggcataaaca tccccgtctg 2072041 ttaccagtat gaccttgcgt tttgtcgtca tgtcggcatt atcctttcgg tttgaaaata 2072101 acagctacga taaaggcgaa aagaatagcg gctgagatac cggccgaggt cagctcaaaa 2072161 atccccatgc cgattccgat aaatccgtgt atatgcgcct gatgcatggc gccgtgcaga 2072221 agactgtgac cgaagctgac gatcggaacg gtggcgcctc ctccggcaaa ttcaataaat 2072281 ttatcgtaaa tgccgaaacc atctaatatt gcaccgatta caacaaatga tgtcatgaca 2072341 tgagctggcg tcaatttaaa aatatccaag agcagctggc cgacgataca gatggccccg 2072401 ccgcagacaa aagccaaaag gtagtccata ttaagatgca cctcctgcac gctcaaatac 2072461 aaccccgtgg gcgatagtcg ggatggtttc tttttgctgg atcatcgtcg ggcttaatag 2072521 cgccccggtc gccacgacaa atacacggtt tagttttcct tctctcagct gcttaaaaat 2072581 atgagagtag gtgacaaccg ctgaacaagc acagccgctc cccccggcaa agacctgctg 2072641 atccggagtg taaatcagaa gcccgcaatc atcatgcttt gtgccgactg gatatccatc 2072701 ttcttttaaa atgtctttta cgattggaga accgacgcct gacaggtcac ctgtcaggat 2072761 tagatcatag tcatccgctg tccggttgag atctttaaag tgctgcttaa tcgtatcagc 2072821 tgcagccgga gccatagccg atcccatatc aaaaggatct gtaattccta aatcagaaac 2072881 cttcccgaca gtcgcacttg tgatttggat atcacccggt gtctgactga tgacaactgc 2072941 accgcttccg gttacagtgg aggtagcagt gtccggtttt tggcctccgt attctgtcgg 2073001 atagcgaaac tgtctttccg cagttgcatt gtgactgctg gtggcagcga gtgccctttt 2073061 ggcaaaccct ccatcaacta aggctgatgc gacagccact gtttccattg atgttgaaca 2073121 ggcgccaaac atacaaagaa atgggatttt caagtgtctt gccacatagt tagccgtcac 2073181 gttttggttc agcaagtcgc ctgccagcaa taggtcaata tcatcttttg tcagattgtt 2073241 tttttgaagt gcaacattaa cagcgtcttc catcagctgc cgttccgcca tttcccagct 2073301 tttttgatta caatgcattt cgtcataggt tttatcaaat aaagagccaa gcggtccgtc 2073361 tttttccttt ggtcctgctg ccgttcccgc tgagttgaca aatatgggat gttcaaatac 2073421 ccaggtttgc tttcctgtta atttcatttt cttctcctcc tatgacatca gtttctcaaa 2073481 agcaaaccga atcattccaa cgatgtatgc agctacaact ccgaaaacaa taacatttcc 2073541 tgccagttta aacatatttg tcgctactcc aagcactaat ccttcgcttt tatattcaag 2073601 agccgcactt gccatactgt tggcaaaacc cgtgacaggt acggctgaac ctgcgcctgc 2073661 gaattgtccg attctgtcat agattccaaa ccctgtaagc agggcagaaa ttaatatcag 2073721 cgttgcagct gttggattcc ccgcagtttt ttcattgaaa tcaaaaaaat ggatataaaa 2073781 attttgcaga ccttgcccga ttgcacaaat cagtccgccc actaaaaagg cttttacaca 2073841 gttccagacg taaggcggct taggctgata tgttttcact tttgatttgt aattttcttt 2073901 tatgtttgtc atcttgaaac ctccttatga atggtcaata aagtacagcc agtgaaataa 2073961 agatcccgcg attttcccaa tcacgatggc cattaacaga ataatgattt tacttctgag 2074021 cccgattcgt ttcgccaaaa tcggcaggac atttaaaacc tctgtaagag cagccgctag 2074081 catcccgacg aacaaacctg ccagaagccc gaccggcaca gctatccatt ttgttagata 2074141 aagatgattc atatgaagcg tctcccatcc cccgcaaacc gcgccaagaa taacagccgc 2074201 ttcataagcc tgaacaaatc tcattgtttt ggtgagctgc atcagccgcg gaatgattcc 2074261 cattacggtt aaaaaagcaa cgaaacccgc ccccaccgtt atgcctccgc cgagcccgac 2074321 aaaaatgatg aacaatacac taacgatcat gcagatcctt tatggtttct tgattctcat 2074381 gcatggccac atattgatcg agatcaagct gatagttaaa catctcaacc tccagcgggc 2074441 tgggctcttc atttaggcgc tttttaaata tgtggttaaa aaacacgatc atccccagtc 2074501 ccaaaccgat gctgtatggg atttgaagca aatatggata gtcattcctc tctccggtta 2074561 tgatttcata tagtgcgata tgaacatctc tcatgcttac atcctcatga aagttcatga 2074621 tggcaagaca cgatccaata aacagaagca gccagacacc gataaataga accgttgata 2074681 aatttcgctt tcgatactga atttcaacaa tggtttctgc tccgcctacg gtttgaacat 2074741 caattgtcgg gtcttgtaaa tgaatggctc tgaggacttg tatgatatcc agaattacga 2074801 tatttttatc tttttcgctc acctgataaa gcggcatagc cgaaagtttc tttttcagct 2074861 gaagctgccc ttctatttgc gcggcatctc caacggtaat aatatcccct ggatgtgcca 2074921 gcactcggtg gcgaagccgg ataaatattc gtcgttccat cattgatcac catctttcgg 2074981 tggttatata tgtagtatgt ggttcgattt tgttctcatt catccgctcg aaaagaccat 2075041 aaattaccac gcttttgcac aaaaaagcta gcctgcactg cagactagcc atccgtatga 2075101 tccatttgaa ccttgatctg ttttaatatt ttcttttcaa gcctggaaac ctgcacctga 2075161 gagatcccga gccgctcagc cacctcggac tgtgtctggt ctttataata tctgagatag 2075221 acgattagtt tttccctttc ctccaaatcg ctgatcgctt ctttcagcgc aattttgtca 2075281 aaccattttt cttctgagtt gtcagcgatt tgatcaagca gggtaatcgg atctccgtca 2075341 ttttcataaa cggtttcgtg aatcgaagat ggagccctta ccgcctcttg ggccagtaca 2075401 acatcctcag cttcaatctc caaatggtca gcgatctcct gcaccgtcgg cactctgccc 2075461 agtgttttcg aaagctcatc cttcgcgcgc cggattttgt ttccaagctc ttttaatgac 2075521 cgtgatacct ttacggttcc gtcatcacgg ataaatcgtt ggatttctcc gataatcatc 2075581 ggcactgcat acgttgaaaa acgcacatca taggttaaat caaatttgtc aacagatttt 2075641 aacagcccga tgcagccgat ctggaagaga tcgtcaggct catatcctct gtttaaaaac 2075701 cgctgtacga cagaccaaac aagacgcatg tttttttcta tgaggaggtc tcttgcctgc 2075761 tggtcgccat tttggctttg tttgattaat tcctttactt catgatcctt cagctgagcg 2075821 tttttgccgt ttttcttaac ctccacatcc ataacaaatc tccttaatta caaagcgctt 2075881 tgctttttga taagtgcttt gttaagcgaa tcgttgttcc catttcaggc gatgaatcga 2075941 tactgacatc atccatgaaa ttttccataa tggtaaagcc cattccagag cgctcaagct 2076001 caggcttagt cgtaaataga ggctgacggg cttcttcaag atctgtaatg cctaagcctt 2076061 catcacgaat agtcatatat acgacatgat cttccagcgt cactgaaatg taaactttcc 2076121 cttcacagtt ctcttcatat ccatggataa tcgcattcgt gacagcctct gacacgactg 2076181 ttttgatttc agtcagttca tccattgtcg ggtccagctg agctataaat gaagcaactg 2076241 tcacacgggc gaacgattca ttctgactga gggcagaaaa ctcaaggtgc atttcatttt 2076301 tcatgatgcc acccccagtg tcaggagtgc ctgctgttca gattgttcaa atcggataat 2076361 tttaaacaga cccgacatat caaacaatcg cttcaccgca ggagagatag cgcaaacaac 2076421 catttctccg ccaatttgct taatttgctt gtatcttcct aaaataacgc caagccccga 2076481 gctgtccata aaggaaaggt cctccaagtt cagcacgata tggcgaatat catccttctc 2076541 caatgattga gtcacttttt gcttcagggt ttcagccgta tggtgatcga gttcgcctgt 2076601 taatcgaata caaagcacag attctttgac attcatgtca attccaaggc tcatgctcat 2076661 tcctccttga tatgatcgga taatgagtgt ttcgatttcg acggaatgaa ttccttcacc 2076721 gtgacaaaac tagtggtcat tcggcataat tacttaaatt ttgtccagtc tcccatcgtc 2076781 cgctttaaga atgtgataaa cccggctttc ttcatatctt cttttgcagc aacaggactt 2076841 tcagcgagta cttctccatc ctttttcaga acaagagtgc caagctcttg gcctttttga 2076901 atcggagcac taatattgtc cttcatcttg atttcttttt tcacatcgtt catatcctcg 2076961 ccttttttcg tcaatattga aatcggctca gatgtagtga gttcgataaa tttttgtttc 2077021 ccttttttga cctttacttt tgctactgtt tgatttcgtt tatataaagg atgcgtttca 2077081 tattggctaa aggcgaagtc aagcattttt gtcacttgcg cgtttctttc tttaggcgtg 2077141 ctcgctccga atacaaccgc tatggcccgc atgtttcctt ttttagccga agcagtcaga 2077201 caatatttcg cttcgcctgt atagcctgtt tttacgccgt ctacaccagg ataaaatttg 2077261 ataaggcgat ttgtatttac aagccaaaac tttttatctg tattttcacg cagataatct 2077321 tcatacgtgc cggtaaactt cgtaattgat tcgtatttca ataattcctt agccatgatt 2077381 gccatgtcat aagcagagct gtagtgtcct tcctcggtca gtcctgttgg gtttttaaag 2077441 gatgtatttt tcaatcccag ctcttttgct tttttattca ttttcttcac aaattcttct 2077501 tcagagccgg aaataaattc agccatggcg acggaagcgt catttcccga agcgattgcg 2077561 atgcctttca gcatttcttt gacagtcatt tcttcgccgg gctcaaggaa tatctgtgag 2077621 ccgcccattg acgccgcatg ctcgcttgta cggaccttat cactcatttt gattttgcct 2077681 ttatctaaag cttccataat caaaagcatc gtcataattt tcgtcatgct tgcaggcgcc 2077741 agtctctcat tgctgttctt gttgtaaagc acttttcccg tgtcacgttc tatcagcacc 2077801 gcagacttcg cttcatgagc aagctccgat gtacgttttc cgtcttgttt tgcaaatgca 2077861 gacggtgcaa atgtaagcag cattatacca atcaacaaag tggataaaag acgtttcatc 2077921 tcaaaagccc tccatttcat aatccttttt attttttcca agcgtgatgg ttttatacgc 2077981 cactgatgga aaatgtttcg aattttgggc ataaaaaaag acagctgtgt gatatcagac 2078041 acagctgtct tttggtcctg cattgattca tatttattcg tactgagcga cgatcgcttt 2078101 aacaagcttt aagaatccag cttttacttt ttcggtcact tccataactt catcgtgact 2078161 taaaggctga tccagaattc cggctgccgc gttagagatg caggaaatgc caagaacccg 2078221 cattcccgca tgattcgcta caatgacttc cggaacagta gacatgccga ctgcatcaga 2078281 gcccatcgtt cttaagaaac ggacttctgc cggtgtttcg taagaaggtc ctgtcacagc 2078341 agtgtacacg cctttttgaa ttgggatatt aaggtctttc gcaatctttt cagccaggct 2078401 ggacagatct ttgtcatagg ctgaagacat atctggaaat ctggcgccga aatctgcttc 2078461 gtttggcccg attaacgggt ttgttcccat aaagttgata tgatcggtaa taatcattaa 2078521 atctcccgca cggaattcag tgttgacacc gcctgcggca tttgtcacga tcaacgcttc 2078581 cacaccgagc gctttcatca cgcgtacagg gaatgtgact ttctccattg agtagccttc 2078641 ataaaaatga aagcggccct gcattgcaat gacggaaact ccttcaagag tgccaagcac 2078701 aagctgtccg gcatgccctt caacagtaga taccgggaat tcaggtatat cttcatattt 2078761 cagcttgacc ggattttcga tttcgtccgc caaaatgcca agacctgagc ctaaaataag 2078821 gccgatcttt ggagattccg gcaggttttg tttaataaaa gcggctgcgc gttcaattct 2078881 gtccttcaag aaacagtccc cctattgtaa taaagataaa aagcttttcc cgtatttcgg 2078941 tttatttgtt tggaaattat cagcgatcgt tgcgccaata tcggcaaatg tatctgcaag 2079001 cggcagcatt tgcgctttct tatgtttttt gctgtaagcg agaatcggca catactcgcg 2079061 tgtatggtca gtcccatgat gaatcggatc attgccgtgg tcggctgtaa taattaacag 2079121 atcgtcttct ctcatttttt caaacacttc cggaagccgc gcatcaaatt cttcaagcgc 2079181 gcgtccgtag ccttcagggt cacggcggtg tccgaataac gcgtcaaaat caacaaggtt 2079241 cgcaaagctc agacccgtaa aatcttctcc cagcgtatcg atcaccttgt ccattccgtc 2079301 catattagaa accgttctgc gtgaagaagt aatgccttct ccgtcgtaaa tatcagagat 2079361 tttaccgatt gaaatcacat ctaagccgca gtctttcaat tcattcatga cagtgcggtc 2079421 aaacggcttc agcgcataat catggcggtt tggcgtccgt ttgaattgac ccggctctcc 2079481 gacgaacggc cgtgcaataa tgcggccaac catatatttc ggatcaagcg tcagctctct 2079541 cgccgtttcg caaatgcgat acagctcctc aagcggcaca acctcttcgt gagcggcaat 2079601 ttgcagaaca gagtcagcag acgtgtaaac aattaaagcc cctgtctcca tgtgctcctg 2079661 gccaagctca tccaaaatcg ctgtgccgga agccggcttg tttccaataa ttttgcggcc 2079721 agatctcttt tccagctctt gaagcaattc atcaggaaag ccttccggga acactttaaa 2079781 cggtttatca atgtataaac ccataatctc ccaatggccg gtcatcgtat ctttgccgtt 2079841 tgacgcttct tgcatttttc cataataggc aagcggatgt tctgtttttt ctacaccttt 2079901 gatatcttcg ataagaccaa ggccgagctt tgccatattc ggcatatgta atccgttcat 2079961 atgctcggca atatgaccga gcgtatgagc gccttcgtca ttaaagtcag cggcatccgg 2080021 cgcttcgccg attccgactg agtccatcac aattaaaaac acacgattat atttgtatgc 2080081 aggcatcttg aaagcctcct ttttttctat acgtctattg tatcgctaag aggtctgaca 2080141 actcaagtat aaaccgtttt cattcccgtt gacaatgtat ttggaaataa tgagaaactt 2080201 caatattttc tgtcgctcta aacaaaaaag ccgcagccac ctgcggctat gctcgcggat 2080261 gaaactgctt gtacacatcc ttcagccttg ttttcgtcac atgcgtataa atttgcgtcg 2080321 tggatatatc cgcatgaccg agcatttcct gcaccgctct taaatctgcc ccgttctcaa 2080381 gcagatgcgt cgcaaaggaa tgcctgagtg tatgcggagt cagctctttc ttaatgccgg 2080441 cttccaatgc gatttttttc aggttcttcc aaaatccctg gcggctgatc tgtttgccgt 2080501 gatgatttaa aaagagggcg tcagatacat tattttttaa cagttttccc ctggcttttg 2080561 tcatatattc ctcaatggcg gaagcagcgg cttcaccgat tggcacaatc cgttcttttc 2080621 ttcctttgcc gaagcatcgg ataaacccca tagataaatg aacatcagcc gttttcaatt 2080681 caatcatttc actgactcgt atgcctgtcg cataaagcag ctccagcatt gctttatccc 2080741 gatatccgaa agggctcgtc agcttaggcg tgtccaataa ccgctcgact tcattgagcg 2080801 cgagcacctt cggaagcgcc cgttccgtct tttgtgtttc gatatgaacg gaagggtcct 2080861 tatccgttac tttttccctg agcagaaatt gatgaaaaga gcgaatggat gccaaatgcc 2080921 gcgccgatgt cttgccggat ttccccgagt ccttcaaatg ctttaagtat tggataatat 2080981 gtatgcgggt aacgtgattc caatctgtaa catgaagggt ttctgttaag tagagagaat 2081041 agcttttcaa gtcacgttca taggatacga tcgtattttg agagagccct ctctctacca 2081101 taacgtagtg gatgaaatcc tttatttgat ctttcactct tgatctactc cccgttttgg 2081161 taaaaaaaga tcaaccggtc gaaccatccg cctttttcat cctgatccat ttcaacaact 2081221 tttacagcgg agccttccgg tttatcatac cgatgatagt tttcatactc ttgattcacc 2081281 catatcatag cataatagaa caaagcggta aaaccggtaa acaggatgaa aactttcaat 2081341 gcatcgacag ctgttttcag gaatcttccc atgtcctaat cgatcctttc cctatggttc 2081401 cagttatata aaccatatgc caaatcagaa aggttttata catagaaaca gcaaaaaacc 2081461 ctttccccat gagaaaaggt tcgcgctcgg caccgtctat tcagtttctt ttccgttaca 2081521 gcggtggcaa atgccgtgaa acgtcaatct atgatcttta atcttaaatt tccaatcacg 2081581 ttcaatgatt tcttccacgt cttcaagcaa atcttcttca atttcatcaa cggctccgca 2081641 ctccatgcac accaagtggt gatgaaagtg agctgcgccc tctttccgaa ggtcgtaacg 2081701 ggacacaccg tctccaaagt taattttatc tacgactttt aattcagtta ataattcaag 2081761 cgtacggtat actgtagcga gaccgatctc aggagatttc tcttttacga ggaggtatac 2081821 atcttctgcg cttaaatggt cttcttcgtt ttcaagcagc actcttactg tcgcttcacg 2081881 ctgtggcgta agtttatagc tggatgagtg cagttgtttc ttaatacgat caatacggtt 2081941 ttccatgtct ttccctccta cgccgcattc catgactcat tataacaaaa tacgcgcaga 2082001 gttccaacta taattattat aaactgataa ataaaatggt tttcttttaa taatgatttt 2082061 aaaaaagtct agatgtaagc ttttccatta aaacaggaga taagtatgct tcaaagagag 2082121 atgaaatcag cgctaaaaac agaatgacca gcagcacaaa ggcataccgc ccgaaccatt 2082181 gaatcggcgc gtcatgcagg cttcgtttca cgaacagctg tctgattaac tttaaagaaa 2082241 acgcaattgc acatgtgccc ataatgagat aagccggaat cagcagcaca ttttgcggca 2082301 aaacggagac aaatgatagg aaaaacccgc ttactcccat ctgattgact aggaacccga 2082361 cagtaaagcc gacgacgatc cctttcagaa agatcataat gaaaataatc ggcatcccaa 2082421 tgacggaaat tcccagtatc cacatcaggc ctaaatactt tgcattatga aagatacttt 2082481 gcccaaacat atcagctgaa cttgcctgtt ttccatccga aagctgtcca aaaaattgac 2082541 ttaagtagta gtataaatct tctttctggc tgatggtcat actgttgaca ataatcgcgc 2082601 caaagatgac acccatgaaa aacagcactg acacaaatat ataaagagag agatgatctt 2082661 tgacatgcct gagaaacatg tccttataag agatttttcg cataccgttt cctcccgccc 2082721 gctctagtga tttgatttaa tagattgtat gaaagaaaca gaaaaacatg ccctttttca 2082781 aaaagaaaca atagagatga atgctaggcg gctttttggg gcacaaaaaa atccttatca 2082841 tcaactgctg tatgatcata aggattctta tgcttccgtt tattcaaaat ctcttttttg 2082901 ctttttgtca ttcttccatg tgtgctgaaa gatggtgtgc tgcctcttga taataagacg 2082961 tcacgtccgc cgtttctcaa tcgatgcccc cgcttctttt tcgcttggct ttttgccatg 2083021 tgatcactcc cttttttatt ttcatagtaa tgataacaaa attgaacaat gataagaaaa 2083081 aaacagcacc tgctacgaca ggtgctgttt agctacattt atttcactgc tgtaagagct 2083141 gcatgctcga cagctgctgc taccgcatga tggacttttg aatcaagcgg ctgagggaca 2083201 acatcacctt gtttagtgca agctgcgatg gcctctgctg ctgcgacaag catatcatga 2083261 ttaatctccg tgctttttgc gttaagcgct cctctaaaaa tccctggaaa accgagtaca 2083321 ttattaacag aacgcccgtc agctgcatat gcggcgccag cctgcagtgc ggcctccggc 2083381 tcaatttccg gcttcggatt cgataaagcc agaatcactt gaccagaacg tacaaatgcc 2083441 ggttttatta aacccggaac gcccgttgta gcaatgacaa tatcacatgt ttccataagc 2083501 tcctcaatac tggaaactgc ctgtccgccg tattgttcga gacggttcat tgctgactct 2083561 gatttgtctg ttccgtatac agcattcaca ccataagcca tgaacatccg gcagatggcc 2083621 acgcctgctg cgccaaggcc gatttgcccc actttcgctt ccttcaggtc aacccccgca 2083681 ctcctgcatg ccgaaatggc agctgccagc gtcactacag ctgtaccatg ctggtcatcg 2083741 tgcataacag ggatgttcag ctcctctttt aggcgatcct cgatttcaaa acaatgcggc 2083801 gaaccgatat cctcaagaag gatgccgcta aagcccggag aaatatgttt tactgttttg 2083861 atgatttctt caggatcact cgtatcaagc agtatcggaa tgccgctaat acccgccagc 2083921 tgatcaaata aagcagcctt tccttccatg acaggcatgc cagccacaga gccgatattc 2083981 ccaaggccta aaattgcggt tccatccgtt acaattgcaa cagaattgct gatcgttgta 2084041 taaatagaag ctttttcagg ttctttttcg atcagtcggc acacgtccgc aacacctggt 2084101 gtgtagacac gtcccagctc tgccagtgaa cggatcggca ttttgctttt catttggatt 2084161 tttccgcctt catgtgcgga caggacttca tcagatacgg tgtgaagcct gatcccttct 2084221 ccgagggcct gtacagccgc gatcacttcc tgaagctgtt cttcattctc cacttgaacg 2084281 gtaatattcc gcattgtgta attgggtccg acttttaccg tctccacttc accaatatcc 2084341 ccgcccagaa ggccgatggc cgtagccacc cttccaagat ttccgggaac cgaaggcgtt 2084401 tcgatcatca gtgtccgaat catgtgtttc gctatcattc agtgatcctc ccctattagc 2084461 ctagtttttc ggctttaact gtattgtttt tcgtatacca tataaatttt cctgtataac 2084521 catagataat tgcaagacct attgctacaa aactgagcca cataaacggc agataagaga 2084581 aggtagaaac acctaaaata ccagccatgt aaatcccatt atcagaccaa ggaaccatcc 2084641 ccgaagtcaa tgttcccccg acctctgagt tacgtgataa cactcttctg tccagatgta 2084701 agcgatcata gctgtcttcc ataattttcg gagtcaaaat aagagataca tacatcgcac 2084761 agccgaagat gtttgctaaa aacgctacga tcagtgtaga caatgtgaca ttgccggctg 2084821 aagttaattt cttttcaaac gttgaaacaa tgacttttaa cacgccgagt ttctcaagca 2084881 gaccgccaaa accaaggcca aagatgatga cgacgagaga atcaagcata ccgacaattc 2084941 caccgcggtt taacaagccg ttcaaaaatt caacatccgt tttaatagag aagccgttgt 2085001 acgcagttgc aatcgcatgg gcaatatcca ttccttggaa aacaacagcc cagattgcac 2085061 cgagtaaagc gccaattacg ataactggca tagatggctt tttcatcgcc aataagacta 2085121 tgacgagaac tgccgggatc agcatccaaa tatgaatgtc aaacgtgttt tgcaaagatg 2085181 attttaagaa ttcaacttta tcaagatcaa tatttttccc gccgtacata aatccaacaa 2085241 ctgtaaagag tatagctgta atgacataag caggtattga taaataaagc attgctctca 2085301 cgtgagccaa tacatcgact tttgatagtg aagaagctag aactgtactg tcagacagcg 2085361 gagacagctt gtccccaaaa taagcacctg aaagaatagc tcccgctact agaggaagcg 2085421 gaatgcctaa cccctctcca attgcgatca tggcaatgcc ggcagttccg actgttcccc 2085481 atgacgttcc tgttgccaca gacataatgg aacaaataat taacgttgcc agtaaaaaga 2085541 tacttgggtg aataaattcc agtccgtaat aaatcaaagt cggcacaacg cctccggcaa 2085601 tccatgttcc gatgagcgcc ccaactgaaa cgagaatcag tacggcttca aggccatttg 2085661 atatcccatg tacaatcgca ttttgtaaat ctttataaga ataaccgagt ctaataccta 2085721 aaagcattgc aataaaccat gaaacaaaaa gcgccagctg tatcggcaag tcgagaaaga 2085781 ctgtaaacga tagaacaagt gctaaaaata ctcctagtac aataataatt tcaaatagtg 2085841 ttggcaatct tacatccttc aaaagaagtc ccccttcatg taaaagctaa aacgctttca 2085901 atatatagtg caacacgtat actatacttc ctcatcccta tgttgtaaac agcttattca 2085961 tccgactatt cggagatgaa taagctgtat tttatacaaa ttttattttt ctaatagttc 2086021 tttccctgcg atacctggtt tggtcatctc atatgggttt aaaataatat ccaattcttc 2086081 ttcagtcagc acatcatgct gcagacaaag atcccggaca gattgccctg tcataattgc 2086141 ttccctggca attctagctg ccgcttcata cccaagatgc ggattgacag ctgtgatcac 2086201 gcctgcgctt ttttctacgt attgcttcat acgcttttcg ttggcttcaa tgccttttaa 2086261 gcagttgtca gtgaacgaac ggaagccgtt gttcatgatg ctgatggatt gaagcaaatt 2086321 aaagacaagc acgggctcca tgacgttcaa ctcaagctgg ccggcttctg aagcaaggca 2086381 gattgtattg tcatttccga taacctggaa cgcaatttgg ttgatcagct ccgccataac 2086441 cggattgact ttccccggca taatagatga acccggctga cgtgcaggca gagaaatttc 2086501 cgcaagtccg gcgcgcggtc ccgacgccat taagcgcagg tcgtttgcga tcttcgacat 2086561 gttcatcatg cagactttta atgaagctga tacctctgta taggcatctg tattttgtgt 2086621 cgcatcaaca agatgatcag cgccgacaag aggaagcccg ctaatatcag caaggtgctt 2086681 tactacctgt ttgatatatt caggatcagc gttcagccct gtaccaacag cagttgcgcc 2086741 catgttgact tcatacaggt gctggcgcga ttgcttgatt cgtttgatat cacgctcgag 2086801 aacacggctg taagcttcga attcctggcc aagacggatc ggaaccgcat cttgaaggtg 2086861 tgtccggccc attttaataa cagagtcaaa ctcctgtgct ttttgcttaa acacactatg 2086921 catatcttcc attgttttca gcagtttttc taagagcttc aatgtggaaa tatggatagc 2086981 agtcgggaac acatcgttcg tagactgtga catgttcaca tgtgtgtttg gacttaaatg 2087041 gatataatct ccctttttat gtcccatgat ttcaagcgcc cggtttccga taacctcatt 2087101 cgcgttcatg ttcatagaag ttccggcacc gccctgaatc ggatcgacga taaactgatc 2087161 gtgccacttg ccttccagaa tctcgtcagc ggcttgtacg atagcttggc caattccttc 2087221 atacagccgt ttcacgtcca tgttggcaag agccgcagct tttttcacaa tcgccagtgc 2087281 gttaatcatt tcctcatgga ttttgtatcc tgtgatcgga aaattttcag aagcacggag 2087341 cgtctgaatt ccgtaataaa catctgcttc aatttgtttt tccccaagga agtctttttc 2087401 cacgcgatat tctttttggc cgtttaacat aatctttaac cttctttctc tttgctggtt 2087461 atcgttttta cattttacag gacaacgtca tcagctatcg gcgtttccat aattctcttg 2087521 acgacaggaa gatccgaaga ctgacctagc gcccacatca attttggcac aattgcttct 2087581 gtgttcatat ttcttgatcg gataattaag tcttggttga ctctgcggcc aacctcgtaa 2087641 atgctcatgt cttcgccttc ttcaagacat tgagtcgtaa tgacgacgac aatgccgctt 2087701 tcgatcagtt cattcacttt tgacaaaatg tctctgcctt caaacggcac tcctccgctg 2087761 ccataactct caatgacaat tcctttgtac atgcttttca gggcatcaaa catttcgggc 2087821 tttaagcctg gatgcagctt cagcagacat acatctgtgc atagtgaagt gtcaactgtg 2087881 aaggtgtcgt tctcaggttc cgttacttgt ttgttgtatt cgatcccgtc ttcattgata 2087941 aaagcgatat atgggtaatt gatgctttca aatgcgtcgt agcttttcgt tcttaatttg 2088001 atcgcacgcg ttccctgaat gactctgccg tcaaacacaa cataaacgcc gcccacgcct 2088061 tcacaggcaa atcgaatggc atctgtaata ttttttttgg catcggtttt ttggaacgtg 2088121 atcggaatct gcgagccggt gatgacaatc ggctttttgg catgctgcag catatacgat 2088181 agtgcggcag atgtataggc cattgtatct gtaccgtgag taataacaaa cccgtcatag 2088241 gcatcataat tttccttaac ggcttctgct atttccaccc agtattcagg ctgcatattg 2088301 gtgctgtcta tattcataag cgactgagtt tccattgtgt aatcgttatc aagttttgat 2088361 acgtaactta ataattcatc agccttgact ccgggagcca gcccattttc cccttcaact 2088421 gaagcaatcg ttcccccagt tgtcaacatc aataattttt tcataccatg cacctcttca 2088481 ctgtatctaa agatgggttg cgagaaggta ttcgcttttc gcatactttt aatgcaatta 2088541 tagacacgga aaataaaata cgcaagacat tattattcaa ttcgcgtaca cttcctaata 2088601 cctatatgat ataatcagct caaggtgaaa aaggagcgga agttcatgaa tctagatcgt 2088661 ttaactgaat tgagaaaaaa gaaaaattgg tcgcttcaat atacagctga ccttctcggt 2088721 atcgcaaaaa gcacatatgc cggctacgag tcaggctacc gacggccttc acttgaagcg 2088781 cttgccatgc tggctgacct ctttgacaca acctgcgatg aacttttagg ccgcgagaaa 2088841 caaaagcaga ctgctcctca ggccatagaa ttggccacgt ggagcagcct cgactttacc 2088901 atttctgttg atggccagcc gctgagtgaa gatgaaatca tccagctgat tacctttata 2088961 cgcacaaaaa gaaaagtaca ggaggaactg agttaatctt tagctcacgg tttaatttta 2089021 ccgtaggttc ctcctcctcc ggctttcaat tccagttttc cggatctcgc ttttacgata 2089081 agcgccgcgg ttttcggcgg gacaacgcga gccaaatctt cttctgcagc ctcatgaaga 2089141 acagccattt ctgttccgaa ggcttttttt agtttgtcca gcgttttcgg gcctacaccc 2089201 ggaacaaatt gcagcgggat ctgatgtaca tatcgcggac gcgggacgcg aacttcaagc 2089261 tgatcactca attcacgcaa tctatcgctg actcccttgg taaatctggc ttttccgcaa 2089321 ttcgcgcacg ctgtttcccc gcttacagca ggctctccgc acgcttcgca agccgtctga 2089381 taatatttcc ccaataacgg gtccaagcca taatttgcga taattttcct gtcatcttgt 2089441 ccctttaatg caagagcaaa ttcagtaaaa tcagctgact gcacatataa ttcattatat 2089501 tctctgccga ttttccccaa cgaatgcgca tcagaatttg ttaaaaaagg atacggattc 2089561 aattgcgata cgtgtgatgc catgtctgta tcacagctta atccaagctc caccgcgtct 2089621 atcatagatg gatcaaaaac ctcagttaag cttgatttaa ccccttttcc atataagctt 2089681 ttatgcggcg taaagatatg ggcggggata aacaggccgc ccatatcctg cacttttttt 2089741 tgcaggttta agcccgtttc ataaatccgc tgcgagctta aatgaatatt tttcagccgg 2089801 gctgacagcc agtttgaaaa ctgtttcata tcagccagcg tcggcataaa tacgagcaca 2089861 tggatcggtc cgctgcaggc ttcatcataa atctccagct cgctccccaa taaaagagtc 2089921 gtgctgcgat aacggattcc tcccccgtca agctcgcgat attttccaga tgaaatgcct 2089981 tcctcaagct ctagaatgac ttccggagaa tgacagtcga taatgccgag gagttcaatt 2090041 cctttatgtt cactggcttc aaccaaaatt ctgtccagcg ttaatgtttt ggcgcctgtt 2090101 attttgacag cccttcctgt aaaggtccgg ccgatatgaa tgtgcaaatc cgcgtaaatc 2090161 tttttcattt ttgtgcttgg agcgcttctt tcagctgaag atactgaatc gcgtaggctg 2090221 ttttagcatc atatacttca cgcgattcaa ccagctttag cgcatcttca agcgtcacct 2090281 ccatcacttc aacaaactcg tcctcatcaa gctcccgttt ttcttcaagc acagaaagct 2090341 cctcagcaag aaaaacgtga acgatttcat ctgcaaatcc gggtgatgta taaaacgcag 2090401 ttatttttgt cagttttttt gctgtataac cggtttcctc ttcaagttcc cgaagtgccg 2090461 tatactccgg ctcctcacct ttttcaagct taccggccgg aatttcaacg atcgtccgct 2090521 caagcggctt acggaattgt ttgaccatga tgattttccc ttcatctgtg acggctagta 2090581 ccgctacagc tccagggtgt ttcacaattt cacgtttact ggctttgccg tttggcagct 2090641 ctacatcctc gacataaaga tcaatgactt tacccgaaaa aatctgttct ttggcaattg 2090701 ttttttcttc taatgatttc atttcttcat ctcccgttct gtctctatat gatgccccat 2090761 acattttatc atactagagc aaaagggggc ttcttcgtga aagtgcaccg catgccaaaa 2090821 ggtgttgtct tagtcggaaa agcatgggaa attcgagcga agttaaaaga gtatggacgc 2090881 acatttcaat atgtgaaaga ttggatctca aagccataaa agttgaaact ttagctcctt 2090941 tatattacgg tcaatacaaa gcctaaaaaa ggagtgtgca catgagaaag cgcaaattgg 2091001 gtacatctga tttagacatt agcgaagtcg gactcggctg tatgtctctt ggaactgaaa 2091061 aaaacaaagc attgtccatt ctggatgaag cgatcgagct tggcatcaac tatttggaca 2091121 cagcggattt gtatgaccgg ggacgcaatg aagaaattgt cggtgatgcg atccaaaaca 2091181 gacgccatga tattattctg gcaacaaaag cgggaaaccg ttgggatgac ggaagcgagg 2091241 gctggtattg ggacccttca aaagcttaca taaaagaggc ggtaaaaaag agccttacac 2091301 gtctgaaaac agattatatc gacctttatc agctccacgg cggcacgata gaggacaaca 2091361 ttgatgaaac gattgaagcg tttgaggaat taaaacaaga aggtgtcatc cgctactacg 2091421 gcatttcttc catccgcccg aatgtgatta aagaatatgt aaaaaaatca aacatcgtca 2091481 gcattatgat gcaattcagc ctgtttgaca gacgccctga ggaatggctc ccgcttttag 2091541 aggaacatca aatcagcgta gtcgccagag gtcctgttgc caaagggctc ttaactgaaa 2091601 aaccgcttga tcaagcttca gaaagtatga aacaaaacgg gtacttgtcc tattcattcg 2091661 aggaactgac aaatgcccgt aaggcaatgg aggaagtggc tcccgatctt tccatgacag 2091721 aaaagtcgct gcagtatctg ctagcacagc cggctgtcgc ttcagtgatt acaggcgcca 2091781 gtaagattga gcagttacgg gaaaatattc aggcagcaaa tgcacggcgt ttaaccgaag 2091841 aggaaatcaa agcgctccaa tctcatacga aacaagacat ttacaaagct catcgctcat 2091901 agcagaaaaa ccagcacctg tacgggtgct ggtttattta tattgatgcc aatccatttg 2091961 gctttcattt aggagttctt caaagctctt atttttttcg atctcttttt tctttctaat 2092021 ctgttctgct ttttctcttt tctgcctctt ttcatcctct tccttcaatt ggctcttcat 2092081 ctccataagc tttgctttga tatcggattg aaggccgtct tttagctggt gtttgtcaat 2092141 ggatttttgt tttttcatgc agacttcccc catgttttgt tttgaagcca gtttatcacg 2092201 gagcatataa actgaacaag cagactctct tctgatcact ttctcagcgt agcagtgttt 2092261 aggtataatg atcttaaaca cgaattgcct atatatttcg ttgaaaggtg ctgtgacttt 2092321 tgaagaaaat ccttttggcc attggcgcgc tcgtaacagc tgtcatcgca atcggaattg 2092381 ttttttcaca tatgattcta ttcatcaaga aaaaaacgga tgaagacatt atcaaaagag 2092441 agacagacaa cggacatgat gtgtttgaat catttgaaca aatggagaaa accgcttttg 2092501 tgataccctc cgcttacggg tacgacataa aaggatacca tgtcgcaccg catgacacac 2092561 caaataccat catcatctgc cacggggtga cgatgaatgt actgaattct cttaagtata 2092621 tgcatttatt tctagatctc ggctggaatg tgctcattta tgaccatcgc cggcatggcc 2092681 aaagcggcgg aaagacgacc agctacgggt tttacgaaaa ggatgatctc aataaggttg 2092741 tcagcttgct caaaaacaaa acaaatcatc gcggattgat cggaattcat ggtgagtcga 2092801 tgggggccgt gaccgccctg ctttatgctg gtgcacactg cagcgatggc gctgattttt 2092861 atattgccga ttgtccgttc gcatgttttg atgaacagct tgcctatcgg ctgagagcgg 2092921 aatacaggct cccgtcttgg cccctgcttc ctatcgccga cttctttttg aagctgaggg 2092981 gaggctatcg cgcacgtgaa gtatctccgc ttgctgtcat tgataaaatt gaaaagccgg 2093041 tcctctttat tcacagtaag gatgatgact acattcctgt ttcttcaacc gagcggcttt 2093101 atgaaaagaa acgcggtccg aaagcgctgt acattgccga gaacggtgaa cacgccatgt 2093161 catataccaa aaatcggcat acgtaccgaa aaacagtgca ggagttttta gacaacatga 2093221 atgattcaac agaataaaaa agcgaaaggc ctcttcggct ctttcgcttt tttatgttac 2093281 agaacgtcgg taatgccatc catattttct ctgatccatt caatcgcaag atctatcgtt 2093341 gtaaactcct gcgtctcgaa ggtcatttca tcctgcaata gccagacatc tttcttgatg 2093401 gactctgctc ctccgattga ccagtgaagc aaggtataag gatggttttg attcaggaag 2093461 gatacccacg ttttattttg tgctgtgttc ttcattgcct tcagcttttg ttccacgttt 2093521 cgcgtctcct actttactaa tatgctcatt ctggggctga gcatttcagc cgggcttttc 2093581 agcgccaatg ttttggcttt ttcattgtaa tcgatcgtca tttgatcgtc aaaaaacact 2093641 ttttgcgacg attggatata cagcggaatg ccgttcgttt ccagctgctc gcactgtccc 2093701 gttaattctt ctgccagcca gattgtcggg acaccgctta ccgcgcagcc gcatccttct 2093761 gcatcgtaac gaagctgggc tttttttccc gggttggcgt caaacgcctg ctgcagtgcc 2093821 tgttttgctg catctgtcac atgtatgttc ataaggtgaa acccccgttt tcatcatttt 2093881 cgctattgta gcatacaata ctgccattcg cattgtttct gccttttttc caccgcttcg 2093941 cattttcttc tgcagtcttg atccactcat ctttcccttg tatatactga ttgatgctgt 2094001 cagggtgctg ggccgccagc tgttttttga gaacggcgta ttctttcgct atgtttggat 2094061 gagctctgag ataatctctg aataacagat gcctttcaat agcagggttt ccctgttcgt 2094121 acatatggac atgatgagtg cgtttatttc cgcccttttg gaaataacgc ctgcccgcta 2094181 taccgttctc accttttggt gtatagccgt tggccttcat ttgttcatca aattggctca 2094241 cggcttcaat gcttctgact tcaattaaca tatcaatgat tggcttcgct gccatgttag 2094301 gtattgatgt gcttccgatg tgatgaatag cgataatctc cggcccgaac acaagtttca 2094361 gccgttcttt ttcttcatcg aaacattctg cccatttttc gttgtagaga atgatctcaa 2094421 cttttctttt cggatacaaa tgaaagaccg acagcaatag accctgcgct gctttgacgg 2094481 tttctgcctt ttggaatccg gcctgtgtat agagtgacac agccggggta ttgttctcgg 2094541 ctgtgactac ttcgattttc tcagcgtctt cattatgatc aatgacaaat tgcagaagcg 2094601 ctcgtccaat tccttttctg aaaccgtcag gatgcacaac aagcctgcaa atggtgagat 2094661 aatgcatgtt tttctcatat gaaatgacac cgatcagctt gccgtttttc cgatatcccg 2094721 caaaccgttc atgggatgct tgaatatcct ttaccttctc ttgtaaagcg ggaataccgt 2094781 caaaaccgat aatctctgtt tcctttatgt aggcggggat ctgtacggct aaaatctcac 2094841 gcgctatagt ggcttcctta tgctggagaa attcaatcat tcgtgttctc ctgaaacagc 2094901 cgctgtctgt cgacttttgc gacgcggact gcatacgact cgtaccaaac gcttcttcct 2094961 ttttcttttg ctgcttgatg ttcagtgtga tgcctccaat ggttaattgc gtccatactg 2095021 tcccaatagg aaactgtgat gccccttcca tccgcttcac gtacgctttc cacgcctaaa 2095081 aatccaggct gatccgccgc aagtgatacc atccgctccg ctgtttctcc atatcctgtg 2095141 tcattttcgc ttttgacaga agaaaaaatg actgcatagt aaggaggctc aggtgttttt 2095201 gataaaaaat ccatcatatt tccccctcat atgtttttga caaatagtac cctgtcttgg 2095261 cccgggccat catagtttgc aaacactgag atgccattta ccgttttggt gcccttttca 2095321 atatcaaacc ccaattttgt gtgatatgcg attgatacct tattcacagg tgaagtgaca 2095381 cacttcaccc gggtgcagcc cctttgtttt actgtttcga taaatacatc atacaattgt 2095441 ttcccaattt gcatttttct gaaatccgga tgcacaccgg aaaaatgaat gtacgccgtt 2095501 tcaggatcgg attgcgattg aaatccgatt aaaaatcccg tcatgctgtt atgttcggat 2095561 gtaataaagc ttgtgtcctg aaaatgctca aaaaatagtc tcggcaattt ttctttcagc 2095621 tgtctgccgc cccaccattc attcagtaca gacgttacca tttcataatc tgaagacgtg 2095681 attgttcgaa tatccattac gatttgatct ccctccgtct ggcaaaacga atgtcagctc 2095741 tttttctcac aatataaaaa ttatattttg cctggctgga attgtaaatg ccttctttcc 2095801 tgtatcatac gtttccagac tgccgaggga acaatgtttg atcattttac gcctatttct 2095861 cccccaaaca ggaggagaga ctttacagca caatatcaag cacttgatca agtttcagct 2095921 tataaagctg atcctcgtct ccttttatcc atactgcttt ttcaaactct tcataccggc 2095981 agattttccc ggtgcagcag acaatctcac cgtcctgaaa gcagctgaca gtgatatcct 2096041 gagcaaactc catcgcggcg caaagcgttt gattcatctc ttccagctta tcggggtcaa 2096101 ggatcggctt ttgcagcttc tgtttaagtc gctttctctc cagcaggctt tgcttatgtt 2096161 ccggcagaaa catcctgctc ccttcccaca gcaggttgcc cctttttaaa tggtcgttca 2096221 tttataatgc ccccctattt tagccgcacg ttcaaatgcc tggcctgccg ctgtcagtga 2096281 cgccgccctg atgattgctg tatcgccgaa tcgattttta atgccatcca tcacatagcc 2096341 taggctcatt ttctttgcat aatcctgaaa taaattgagc tgccatatgt catcagatga 2096401 gagctgagac agattgacac cgaggcggcg gacgggtttc ccgtcccaaa atgtaagaaa 2096461 cagccgtcgt acagcctcat atacatcctg cgtagaatta gtcggctctg ccagcttcac 2096521 ttgccggttg aagcccgtcg gccaatcaaa atcagcaccc cggcagctca ctgacactgt 2096581 ctgccccatg accccggcgt ttcggcttcg cctgcacacc tcttcactca gctcaagcaa 2096641 tacgaccttg atttctttgt caaagtgttc gtagtctctc gggagagtca ttccatgacc 2096701 tatcgccttt tgcccgtcca gagacgaagt tgacacaggg gaatagtcga ttccgtttgc 2096761 cgtcatccac agcacgtggc cgttaatgcc ccatttcttt tttaaaagat cgagcggaaa 2096821 agccgcgagc ccgccgatcg tgctgatgcc cattcgattt aaatgatgct tcatgcggct 2096881 cccgacgcca aacatgctgc ccaccgggag cggccacatt tcggttttca tattttcttt 2096941 cgttaaggta aaaataccgt tcttattctt tttggcaaaa ttgtcacacg caattttggc 2097001 cagcgctttg ttagggccga ttccgacccg tgcataaacg ccgatctccc gcatgattct 2097061 gccctgaatg cttttcgcga tctccatcgg cgtcccaaac agcttctggc tgcctgtaat 2097121 gtccatgaac tgttcatcga tggaatacgg ctccacaagg tctgtatact cctcgagaat 2097181 ggccgtaatt tgcagtgata catcaatata ccgctgcata cgcggccgga gcacaacagc 2097241 ctcaggacac ttttcctgcg cctcccacag ccgtgaagca ttcaccacac ccttttgttt 2097301 cgccagcggg caggcagcca atacgactcc gccccttttt tcagggtcac ccgaaacaat 2097361 gacgggccta tttttcaaat gtggattttc cgctttctct acagatgcat aaaacgattg 2097421 catgtcaacg agaaaaatca ctttttcttt catcatacac acctctaaaa agaacttatg 2097481 ttcgcttttc attatatgcg aaagtatgtt cgttttatac tggtaaatga ttcttgtctg 2097541 acagaaaata tgatccaagg gtttgagaga agaaaaacat ttagtagaat aaaagcgaag 2097601 cataaggata ggagagtcat gatggagaaa tttgtcgaaa aaatgctggg acaggcattg 2097661 cggcaatacg gcagaaacgt tgctatagat ccgttaagcc cgtatgaaaa acaaagcctg 2097721 aaagcggctc tacaagagag acggaatgaa gaaccagatg aggatttgca tgcgcatata 2097781 gaagatatca tttatgacta tgtcacaaac caaggcctgt tctcttaaac gcatgactgt 2097841 cagttctttc agccgctgat gcggcttccc tttgaaaaca ccgcctgaaa caaataaaca 2097901 gtctcaggct tacagaaaaa aagcaggatt ttctcacgct ccatagattc atatggcctg 2097961 gcgtaaaatt cccctcaatg ctcgcgcaaa acggaataag ctgtccatga tcacgcgtat 2098021 acactttttc gaagagatgt gctctcttgt tctgtcatgc ggtccatgcc ggttttcagc 2098081 gtacatcttg atctcatagc cggtttcact gccgatatga tccacgttct ggcggcttaa 2098141 actaacacac cctcactgac caatcgcttt gcttttcatc ggacatcccg tcattttcct 2098201 tctttcaaga tgtaaactcc gtcagccaca cgcatcctca acgcatagta tattgccatc 2098261 catacaatca ggcatactac atgtcaataa cgaaatattt tgaacgatct attggagaag 2098321 gaaatttttt catatatgat agagaaagat catacataca ggagagaata taattcatga 2098381 agaaatggaa agatatccac ccgatcagct ggacaattat aatcggaacc attttcggca 2098441 gaatggcaac atcgatgagc attccttttt tagcgattta tttgacagcc gtccaaggcg 2098501 catcagcttc ctatgcaggg ctggtcatcg ccgcgagctc atcagtcggc atcctcgcaa 2098561 gcttttacgg cggatatatc tcagataaat tcggcagaaa aaacatgatg cttgtatcga 2098621 ttttcggatg gatgctggta tttgcaggct ttgcggcagc atctaatctc tgggtgtttt 2098681 ttgtagtaaa cgcattaaac ggtctttgca aatcactgtt tgagcccgct tcaaaggcct 2098741 tgttgtctga tatgacagaa gaaaaaacga gactgctagt ttttaattta cgctatgcgg 2098801 ctattaatat cggcgttgtc ttcggacctg tgcttggcct atatttcggc tcatcgcaat 2098861 cgactacgcc ctttttggtg cctgcagtca tttacggact atacggaatt gtgcttgccc 2098921 tccaatttaa aaaacatcca tccttatcag caccagccca gtcccgaaat atgagcgtgc 2098981 gggaagcgtt tatggtcacg caaaaggatt atctttttac cattgctttg gtcggcatta 2099041 cgctatgcac cttcggctac tcacaattca gttccacatt ccctcagtat atggcgcaga 2099101 accccttgat cggcaatgga acgaagctgt atgggctgat gctgacatta aacgcaatcg 2099161 ttgtgttggc gacgcaattt cccattgtcc attttgcaaa acggttttcg ccgctttgtt 2099221 ctctgatgct cggtaatgtg atggttagca tcagcatggc cattttcacc gtatcacacg 2099281 gtgttccatc aattgtgatg attgtcatca catttacaat cggcgaagtg cttttattct 2099341 ctatgatgga tttgtatgta gaccagattg caaaaccagg attaaaaggc acttatttcg 2099401 gggcaatcgg tttttcacag ctcggaaacg tcatcggccc ttgggtcggg gggatatgta 2099461 tagacctgtt tggcgctggc cggccgattt atattttttc tgtcctgagc ggcattaccc 2099521 tgctcggcct gccattttta gcgttcgcct atcggcaaat gaaaatggag accacaaaac 2099581 accgttcccg tctggaaaag ccgctttaaa taaaaaacgg aagagaatga atctctcccg 2099641 caaacatgag gtgaagaaca tgaatatagg tgatgtgatg tttcagctgt ttgtatttat 2099701 tatatttgcc gctgtcgtct ttgcggctgt tacaggcttc aagtatgcga aaaaccgaaa 2099761 agcgcagctg gatcgcattg agaaaaagct gaacagcctg tccgaagatc acgattaaca 2099821 gcttggggca acgagctcta ccttaatccg gtctggatcc tcacaaaaga ctgcataatg 2099881 cccgtctcct ccggcaaaag gatgcctgtc tcggtacaac acacgatagc cttttgccgt 2099941 caatttttca gtcatctgat cgacttgaag cttggattca gcatgaaatg cgagatggtt 2100001 cagaccgact cggcatctat ggtattccgg ctctagaaat ggctctttcg cctgcacaat 2100061 cactaggtaa aaacgatctt tcttccagct gatgcctgag ctccattttt gatactcttt 2100121 ataaccaagt tcttttaaga accagcccca aaaccgccta gacgcctcca aatcagagac 2100181 atacagttca atatgatgca catttcatac cctccttacc aacacttcct cgaccttatg 2100241 cccgtctccc ttacgcaaaa tgagatctga cctgaattta gttggcaaaa tattttcata 2100301 taaattcggc cggttgacac tctcccaaat cgaggctgcc atctcgtcag cctcctgatc 2100361 ggacaagtct ttaaatttat gaaaatatga atcaggattt tgaaaagctg tttcccgaag 2100421 caggcgaaaa cgctctaaat accaagtgaa aatccggctt tcctccgcat ccacataaat 2100481 cgaaaaatca aagaaatcgg aaacaaaaat acgcgggttt tcccggtcat cctccaaggt 2100541 gggcgactga agaacattaa tgccttcaat aatcacaata tccgcctgtt ctacaacctc 2100601 gaacacacct tcctcgcggt cataggttag atgggaatac accggggcct ttacgctgtc 2100661 ctttcctgat tttaagtcat tcaaaaattc gagcagcgcc tttacatcat agctttcagg 2100721 aaatcctttt cttgacatca tatttttctt tttcagctcg gcagtaggaa ataaaaaacc 2100781 atctgtcgtg ataaggctca cttttggacg gtcaggcaaa cgcgaaagca gcttctgcaa 2100841 gatccgcgcc gtcgtgcttt ttccgactgc gacactgccg gcaatgccga taataaacgg 2100901 aattttggct gaatgtgggt gcttcaaaaa aacattgaca tgcttattgc gttcagccgc 2100961 agacttgaca tgtaaatgaa gcaagcgaac aagcggaata tagatcgtct ccacttcttc 2101021 aacagataga taatcattca atccttccac agcttttgcc tcttcttcag atacagcaat 2101081 cgacaaatgc cccccaaaac cagaccaaga ctcccgattg tgctgtgtat ataaagtatg 2101141 taggttaagt tctttatttt tcactgttta cacctgactc tctgtaggtt aaaaccctta 2101201 caaagattgt aacggaaaac cttttcactg tctgcttatt tttcatttcg tttttttagc 2101261 aaatcagcac cgattcggtt atacgcagcc atttcatctt ttggaaccat gcttcctccc 2101321 gttccccaga cgacatgtac ggcatgttcc atcttatatt tctgagcata gcgccttccc 2101381 tcttctgtcg aaaaaagctg aaccggcccg aacatgccag caagagcaga gggctctaaa 2101441 tatttatctt cagatacagc cagcatatga agcaaagtat aaagcgtatt gtcctctacc 2101501 gtataacagc cgctcagaag cggttcaatc agcttgccga caaatcctga cggcctccct 2101561 acggcaagtc cgtcagcagc cgtctgatta tccaggccga tatcctggac ggagatcttc 2101621 tcgtgaagtc ctgaataaag ccctaacagc atacaaggtg aatgagttgg ttctgcgaaa 2101681 aacacatgaa catcatctcc gtataaaagc ttcagcccaa atgctacacc gcccggtcct 2101741 ccgccgactc cgcacggcag atacacaaac aagggcgtct caagacttgg ctttatattc 2101801 atacagtcaa gctgtgtttt taatcggctt gcagcaacag catatcctaa gaacagctga 2101861 cgagaatgtt catcatcaat aaaataacag aatggatctt gttccgcctg ccgtctccct 2101921 tcgttcaccg cttcactgta atctgtttcg tactccataa cagtgactcc cttttggcgg 2101981 aggagatcct ttttccactg cttagcatcg gcggacatat gcactgtcac gcgaaacccg 2102041 agtgccgcgc cgatgatgcc gatgcttaaa cctagatttc ctgtcgaacc gacagcaatc 2102101 gaatagcggg agaaaaaccc ggtaaaccgc tcttcctgta agatgcggta atcatcggtt 2102161 tcctgaagca ttccttcttg aagcgcgaga ttttcagcat actttaacac ttcataaatc 2102221 ccgcccctcg ctttaatcga tcctgaaatc ggaagctcat ggtcgcactt taaaagccat 2102281 cttccgggaa atggctgctg atatgccgct tccagctttc ccttcatatg ctgcacctca 2102341 aaaagcggag actcgatgat tcctttagcg cctttcgtct caggaaacac ctcggcaatg 2102401 taaggtgcaa accgctgcat tcttttttcc gcttccgcta tctcggttgc ccactcatct 2102461 gcacggggta atggcccctc tttcttgcct gaatttgccc agaatacagg ctctgcatca 2102521 atcagtttct gaataaacgg atctttaagc agagcatgaa ggacttctga atgaactgac 2102581 attcaacaat ctctcccttc cactatcaaa aactgccccg tgagaaacaa gccactccac 2102641 cacaggcagt tctatcatta ttttttcatg agcgcgcgtc ctgccagctt ttctacaaga 2102701 gctggaaaca gctgatacag cttagtgccg gcattcatta aacgcggaag attgatctcc 2102761 cgctttttcg taaaaattgc agctgtaatt tgagctgcca cgtcatcagg atcaagcatc 2102821 cagcggccga catttttggc gtagtccccg cctttatcag caatggaaaa aaagtccgtc 2102881 tgaatcgggc ccgggttgac tgttgtcaca taaatgccgg ttcccgaaag ctccatccgc 2102941 aaagcgtttg agtaacctaa cacggcatgt ttggtcgcgg aatacaggct agacttcggt 2103001 gtggcgattt tccccgcttg agaggcgata ttgatgatat gtcccttttt ttgctcaagc 2103061 atttgcggaa gcaccgcttt tgtacaggcg atcaggccga agacattcac atcaaacatc 2103121 gctttcatgt catccaatgt agagtctaaa accgtttcaa atataccgaa gcctgcattg 2103181 ttaatcagta catcaatcga gccgatctga tcgcggaccc gggcgatatc ctctaggcgg 2103241 ccgacatcca gaggaaaaat ctcacactgt ccgctccatt cctcggttat tttccttttg 2103301 atttctatca aacgatcctc gcgtctagcc gacagcagga catgggctcc ttcagccgcg 2103361 cataagtatg cgattctttc tccaagccct cctgaagcgc cggttatcca aatccttttt 2103421 cccgctatat gtttcaccca tttcacctct tcattgtttt aaagtatacg gtatttcctt 2103481 cccaatatga cgtgatggct tcttcagcct ccaacacatc aaggtgacct gccgtttctg 2103541 acatcgttaa aaacaattcc ttttcatata cagcaggaaa aagctgctga cagacctgaa 2103601 aagcggtcat cggcttttca tccagcatgc gacgcacatc ctccgtcctg ttcctctgct 2103661 tgtcaaaacg cttctcaatc agcgcttgta cactggtgat aggctcgccg tgaccaggaa 2103721 atacgattgt tggatcaagt tgagacagcc ttcgcaatga ccgctgataa tccactaaag 2103781 gctttgacct gacgtctccc gctttcggcg cttccaaaat cggattagac gagctgtttg 2103841 ccagcagtag atcgccgcca agcatccttc cgcttttttc atggaacaga acaatatgcg 2103901 attcagcatg tccaggcatc tccaacacag accagccctc aagcccatct atgcccatac 2103961 cttctctgat tgattttgtc agagatctcg tacaggaaaa tgcgtacgct gatcgaatca 2104021 gcttttccgc cttccccgta tcaaatggaa cgcctaattc aggcagcagc ttttgaaaaa 2104081 aacgtttttg ccaatccata aaggcttgat tttggctgat ataaggttcg ttgaatgtat 2104141 gcccaatcac ttcgatttca tctgaaaaga catcaagcaa gcctgcatga tcagcatgat 2104201 ggtgagtcag tacaacctgc tcgatatctg acaatttcac atttacagcg gcaagctgct 2104261 cttgtaaggc tctggcagcc tcttttgtat tcggcccggc atcgataagt gtcagcgcat 2104321 caccttttac gaggtaaacg ataacatcgc cgacagcaaa cggtgtcggg acgcggatcg 2104381 caattacatc ttcagttgtc atcctttcgc tccttgtctt cattcattat tcatatttta 2104441 gctttttctc ggtcttgtgt cattattgca gaatgagaac aaaccttttt gaaaaagcta 2104501 ttgacattag cttgtccgcc attgcataat gaacaacaaa ctaaaacgag aaccattgga 2104561 acgctatgac gaggaatagt atacaaggca atggcctaag agagcgatac ccccggctga 2104621 aaggtgttgc ggcccgcttg tttgtagaac ctgccctcaa gtcgcggtta ggaaaaccta 2104681 aacgtttccc gcgttacggg gatttgagct gagcacaatt tgtgctaatg agggtggtac 2104741 cgcgaacctt ttcgtccttt acgtgatgaa aaggtttttt gttgttctaa tagaaggagg 2104801 atatcaatga aaaagatagg atttgtcggc gccgggtcaa tggcagaagc aatgatcaac 2104861 ggcattttgc aaagcggcat cacaaaacca gaacatatct atattacaaa tcgctcaaat 2104921 gacgagcgtc tgattgaatt aaaggaaacg tacagcgtgc gtccatgcag agataaaaat 2104981 gagtttttca ctcacaccga tatcattatc ctcgctttca aaccgaaaga cgcggcggaa 2105041 agcatcgaca gcatccggcc gtatatcaag gaccagcttg tcatttcagt acttgcaggc 2105101 cttaccatcg aaaccattca gcattatttt ggcagaaagc tcgcggtcat tcgcgtcatg 2105161 cctaatacat cagcggcaat cagaaaatca gcaaccggat tttccgtaag cacggaagca 2105221 agcaagaatg atattattgc cgcaaaagct ctattggaaa caatcggtga tgcaacactg 2105281 gttgaggagc ggcatcttga cgctgtcact gcaatcgcag gcagcggccc ggcctatgtg 2105341 tatcgttata ttgaggcgat ggaaaaagca gcacaaaaag taggattaga taaagaaacg 2105401 gcaaaagcac tcattttgca gacaatggca ggggcaacag atatgctcct ccaaagcggc 2105461 aaacagccgg aaaagctgcg taaagaaatc accagtcctg ggggcactac agaggcaggt 2105521 cttcgcgctt tacaggactc ccgctttgaa gaagcaatta ttcactgtat tgaagaaaca 2105581 gctaaacgga gcgcagaaat caaagaacag tttgccggtg ccgccttaga gagacattct 2105641 tagatgtaag gacaaaaaca gaaggcacag tgccttctgt tttttatttt tcccgcagca 2105701 gctggccggc agattctgat tgctttaata gcgcggagat cgtaaatgaa agcaaatcgg 2105761 gaagcacttc aaaggaataa ggcatataca atctttccgt ccatttatgc gggtctttac 2105821 cagccggacc gacatttaaa actgggacat ataaagcctg atttttaccg cttggcaatg 2105881 aataccctct gttaaagagc ggcatattgc ttgtgtatgc atcaacctcc tgtttttcca 2105941 gctgaagata actcaagtcc gaaagtccgg ggaagtactg aacctcccgt aatgcaatgc 2106001 cgtatcgctc agccgcataa tgctttatct gatctgctgt atttctgatc aattgatcat 2106061 cctttgaaga aacagctgga taaagcggcg gactataaaa cagaacgatg agcggcgcat 2106121 cctccttaca aagcgaagca agctcagaaa caattttcgt cgaaaaatcc ctgtctccaa 2106181 gctcccccct gttagcaaag gcataattta gagcccgctc tgtttccgag atccccgcac 2106241 gcttttttgc acgcgagacc agctcatcaa atgtcaaaac agtgacgtcc cgctcaatcg 2106301 gctgaaatgg ctcaaattgt tgaaaatcct gtgttttctt ccgaacgttc gacatgattt 2106361 cctccgccgc ctgttctgct gttttaagca gcatctgatg cagctcacta gctgagcgtt 2106421 tcattgacag cacattaaat aatgtgacgg ctgtatgcgg tgtctggact gaatatgcct 2106481 ctttcaagtc cttttgcatt aagtttaccg gcggcggagt gacctcgcca tcaacctttt 2106541 cgcaataatc agcattcagt tcaagcaaac ggttaatctc agataccatt aaatttgcgt 2106601 ttagacctga aaacggctct ccaacatgtg tctcaatccc cttgcagaaa aaacccgcaa 2106661 gcaccttgcc aatgcttcct gtataaaaat attgctgctg atcgccggga aatttttcaa 2106721 acatcggttc ggcattcagg caagcggtta atgtgatatc atgctttttc tccatctcct 2106781 tcaatgcagg aaccgcttca atcatgcctc ttgaattcac ttcctcgtcc ggaaccgtta 2106841 tcaacagcag attgccctca aaatgcccgt tcattgccct ctccagcatc gacagttgaa 2106901 tacaaagccc cgctttcata tccatcgtcc ctcttccgaa cagccagtct ccgctttcgg 2106961 catctcttct cacacgttcc gggagcagct cttttttctc taaaaaggag ctcaaaagct 2107021 cagcaggctt gcaagccata tgtttaaatt cgccgtaatc ttctatgtca acgacatcaa 2107081 aatgactcag cagaagcact gtctttttga cattcttctt tttgactaga gccgtaagaa 2107141 aagatctgcc atcgtccatc ggatgaagtg ttacatcatc agggtgcttt tgaaaatagg 2107201 gcttgtcctt caaaataaaa taaagatact ctgcaagcgc tacctcgccc tttgaaccgg 2107261 tgatgctttc gtattgcaca agagaagtta aaagtgccag caattcgtcc ttcgtctgcc 2107321 aattcattga ttccgcccct cctatgaata aaaatgcttc tatactgaaa aataaactga 2107381 tttctcgtct attatacaga aatgtttgac aaaagcggtt catttgagca gtttatatga 2107441 cgggaaagaa atgacttgat ataatcaatc tctaaaaacc ttacgggagg cgaaagaaat 2107501 ggccagaaaa ttatttacac ctattacaat taaagatatg acgttaaaaa accgcattgt 2107561 catgtcgcca atgtgcatgt attcttctca tgaaaaggac ggaaaattaa caccgttcca 2107621 catggcacat tacatatcgc gcgcaatcgg ccaggtcgga ctgattattg tagaggcgtc 2107681 agcggttaac cctcaaggac gaatcactga ccaagactta ggcatttgga gcgacgagca 2107741 tattgaaggc tttgcaaaac tgactgagca ggtcaaagaa caaggttcaa aaatcggcat 2107801 tcagcttgcc catgccggac gtaaagctga gcttgaagga gatatcttcg ctccatcggc 2107861 gattgcgttt gacgaacaat cagcaacacc tgtagaaatg tcagcagaaa aagtaaaaga 2107921 aacggtccag gagttcaagc aagcggctgc ccgcgcaaaa gaagccggct ttgatgtgat 2107981 tgaaattcat gcggcgcacg gatatttaat tcatgaattt ttgtctccgc tttccaacca 2108041 tcgaacagat gaatatggcg gctcacctga aaaccgctat cgtttcttga gagagatcat 2108101 tgatgaagtc aaacaagtat gggacggtcc tttatttgtc cgtgtatctg cttctgacta 2108161 cactgataaa ggcttagaca ttgccgatca catcggtttt gcaaaatgga tgaaggagca 2108221 gggtgttgac ttaattgact gcagctcagg cgcccttgtt cacgcagaca ttaacgtatt 2108281 ccctggctat caggtcagct tcgctgagaa aatccgtgaa caggcggaca tggctactgg 2108341 tgccgtcggc atgattacag acggttcaat ggctgaagaa attctgcaaa acggacgtgc 2108401 cgacctcatc tttatcggca gagagctttt gcgggatcca ttttttgcaa gaactgctgc 2108461 gaaacagctc aatacagaga ttccggcccc tgttcaatac gaaagaggct ggtaatgccc 2108521 ataagagata tcctgtagag gatatctctt tttttatttt tagagaaacg atcggctaag 2108581 gttctccgtc tccctagtag aaccaattag aggagatgac tccaatgaaa tcagcttgga 2108641 tggaaaagac atatacaatt gacggatgtg cgtttcatac acagcaccgg aaaggatcaa 2108701 gcggtgtaac gattgtcttt gaggccggct atggtacttc ttctgagacg tggaaaccat 2108761 taatggcgga cattgatgat gaatttggca ttttcacata tgatcgggca ggcataggaa 2108821 aaagcgggca aagcagagct aaacgaacag ctgatcaaca agtgaaagaa ttggagagtt 2108881 tgcttaaagc agctgatgta aaacctcctt atttggctgt ttcacactca tacggagctg 2108941 tcatcaccgg tttatgggcc tgcaaaaaca agcatgatat tatcggcatg gtccttcttg 2109001 acccagcttt aggcgattgc gccagcttta cctttatacc cgaagaaatg cacaaatcac 2109061 atacgagaaa gatgatgctt gagggcacac atgcagagtt ttcaaaaagt ctgcaggagc 2109121 tcaaaaagcg gcaagtccac ttaggaaaca tgcctcttct tgtgttgtca tcaggagaac 2109181 ggactgagaa attcgctgct gaacaggagt ggcaaaactt gcacagcagc atattgtctc 2109241 tatctaacca aagcggctgg attcaagcta aaaacagctc ccacaacatc catcatgatg 2109301 aacctcatat cgttcacttg gctatttatg acgtatggtg cgcagcgtgc cagcaggccg 2109361 ctcctcttta ccaggcagtc aattaacgta aaaaaagacc gggccgtaag ggattcccgg 2109421 tcttttatat tattttgttt cacggtgaag ggtatatttc tttaaacgcg gtgaatattt 2109481 tttcagctcc aaacggtctg gattggtgcg tttatttttt gttgtgatgt aatttcggtc 2109541 tcccgtttca gtgcaaagct aaagtaacat ttactctcat aattaacatc tccttataaa 2109601 acgtaatgat tacgttttat tatacaacgt catcacaaat tgtcaaataa gagctccgcc 2109661 ttcagcctcg cgggacgttt acctctaaga aatcatatgc cgccacgcta ttggggaaaa 2109721 cgtcaaccgc ttctttttga agctccaaag aagcatctcc ctgatatctt gcgctgatat 2109781 gggttaaaat gagctgcttc gctcttgctt ctttcgctgt tacagccgct tgttccgttg 2109841 tactgtgata ataatcataa gcaagtttac ggtcttcctt agcaaaggtt gcttcatgaa 2109901 caagcacatc acaatccctc gcaagctctt ttagtttgtc acttactctc gtatcaccgg 2109961 agaacacaac agatcttccc tttttaggag gctccagaaa atcattccca ttgatgattc 2110021 gtccgtcttc aagcgttacc gtttcgcctt ttttgatttt ctgatataca ggtccgggcg 2110081 ggatgttcat ttcttttaat acgtcagcct tcaaggaacc cggtacgtct ttttcctgca 2110141 cacggtaccc gaaggcttcc actccatgaa taacagatac cgctgtgaca ataaactgat 2110201 cgtcctcaaa cacgattcct tcttcaattt cctggatcgc aagcggatat gtcaaatggg 2110261 ttttcgtgac ggcaaggctt gtttcaataa acgccttgat ccctttaggt ccgtacactg 2110321 tcagctcgtc ctctccgcct tgaaaggaac ggctccccag aagccccgga agtccgtata 2110381 catgatcgcc gtgcatgtgt gtaataaaga ttttctctat tttacgaggt ttaatcgttg 2110441 tatgtaaaat ttgatgctgt gtggcttccc cgcagtcaaa aagccatacc gaacgccttt 2110501 cttcaagcaa ttttaatgcc accgacgtta catttctcgc cttggcgggg atgccggctc 2110561 ccgtccctaa aaaaagtaat tccacgtttc cttcctccta ctagaaccag atacctacaa 2110621 gaatacagga tcaagcggaa aatgtgaatc ttgcctctga aaagaacaat cctttcgtgc 2110681 tagaaacatt ttttcagcat tctgcttaaa aaagggctta aatgtttgct ttcgttgaat 2110741 tttagattta aaatgaagga aatatacggg gtgtactaaa ataaagcttc gaataaagtg 2110801 aggtactttt agtgaaaaca aaccaacaac caaaagcagt aattgtcata ttcggtgcaa 2110861 ctggagattt agcaaaacga aaattgtatc cgtctattca ccgtttatat caaaacggac 2110921 aaatcggaga agagtttgca gtggtaggag ttggaagaag accttggtct aatgaggatc 2110981 ttcgccaaac tgttaaaaca tccatttcct catctgcaga taagcatata gatgatttca 2111041 cgtctcattt ttactatcac ccgtttgacg tgacaaaccc tggttcttat caagagctaa 2111101 acgtattgct taaccagctg gaagatacat atcaaattcc taacaacaga atgttctact 2111161 tggcaatggc tcctgaattc ttcggaacga ttgcaaaaac attaaaatca gagggtgtaa 2111221 cagctacaac cggctggtcc cgccttgtca tcgaaaaacc gttcggccat gatctgccaa 2111281 gcgcacaggc attgaataaa gaaatccgcg aagcatttac ggaagatcaa atttacagaa 2111341 tcgaccatta tctaggcaaa caaatggttc agaacattga agtgattcga tttgccaatg 2111401 cgattttcga accgctttgg acaaaccgct acatttcaaa cattcaaatc acatctagcg 2111461 aatcactagg cgttgaagac cgcgcaagat attacgaaaa atcaggcgcc cttcgcgaca 2111521 tggtgcaaaa ccatattatg cagatggttg cccttcttgc aatggagccg cctatcaaat 2111581 tgaacacaga agaaatccgc agcgagaaag tgaaggtgct gagagcactg cgtcctattg 2111641 caaaagacga agtggatgaa tactttgtgc gcggacaata tcatgctggt gaaattgacg 2111701 gtgtaccggt tcctgcttat acagatgaag ataatgtcgc tcctgactcc aatacagaaa 2111761 cctttgttgc cggcaagctc ttgatcgaca acttcagatg ggctggtgtt ccattctaca 2111821 tcagaaccgg aaaacgaatg aaagaaaagt ccacaaaaat tgtcgttcaa tttaaggaca 2111881 ttccgatgaa cctgtactac ggtaatgaaa acaacatgaa tccgaacttg cttgtcattc 2111941 atattcagcc tgacgaaggc attacgcttt acttaaatgc taaaaagctt ggcggagcag 2112001 cacacgcaca gccaatcaaa ctcgattatt gcagcaattg caatgacgag ttgaacaccc 2112061 ctgaagcata tgaaaaacta attcacgact gtcttcttgg cgatgcaaca aactttgcac 2112121 actgggatga agttgccctt tcttggagct ttgtcgactc tatttctgaa acatgggcag 2112181 caaacaaaac cttatctcct aactacgaat caggctcaat gggaccgaaa gaatctgatg 2112241 atcttttggt gaaagacggc ttacactggt ggaacatata ataagaagaa aaaagccgaa 2112301 aatgtttaca agcattttcg gcttttttac gctgaacaaa ggtataacaa tctccttaat 2112361 aacaaaaccc ccaaagctta agagcttcgg gggtttctat tgattacttc atccattcag 2112421 tatggaagat gccttctttg tcagtacgct cataagtatg agcgccaaag tagtcgcgct 2112481 gtgcttggat taagtttgca ggcagtacgg ctgtgcggta gctgtcatag taggctaatg 2112541 cgcttgagaa tgatggcacc ggcacacctt gggcaactgc aagtgaaatc acttggcgaa 2112601 gcgctccttg atagctttct acaatattct tgaaatagct gtcaagaagc aggttgtcaa 2112661 gctcaggctc gcgatcgtaa gcttctttga tcttctgaag gaatgccgcg cgaatgatgc 2112721 aaccaccgcg gaagatcata gcgatttcac catatttcag atcccagttg tattcttcag 2112781 aagcagcttt catttgggca aatccttgcg cgtatgaaca gattttactc atgaacaacg 2112841 cttttctgac cgcttcaatc agctcttctt tattttctgt aacaggcttc acttctggtc 2112901 ctgaaagaag tccgctcgct tttacacgct cttccttcat agctgagata aagcgtgcga 2112961 atacagattc agtaataatc ggaagcggaa cgcctaagtc aagtgcgctt tggcttgtcc 2113021 attttcctgt tcctttttgg cctgctttat caagaatcac atcaacaagc ggtttgcctg 2113081 tttcttcgtc tttttttgtg aagatgtcag ccgtaatctc aatcaggtag ctatcaagct 2113141 cacctttatt ccattcagcg aaaacttcat gaagctcatc agcagaaagg cccagcacct 2113201 gtttcagaat gaaatatgat tcagagatca gctgcatatc tccgtattca attccgttgt 2113261 gcaccatttt tacgtaatgg ccggcgccgt ccggaccgat atatgtcgta caaggttctc 2113321 cgtcaacttt tgcagaaatg gcttcaagaa tcggttttac aagctcatgt gcttcttttt 2113381 gtccgccagg catgatagaa ggtcctttaa gcgctccttc ttctccgccg gaaacgcctg 2113441 ttccgataaa atgaatgccg ctttcagcga gttctttgtt acggcgctgt gtatctttat 2113501 agtatgtatt accgccgtca attaaaatat catccttctc tagatgagga agaagagatt 2113561 gaattgtcgc atctgttgca gttcccgctt taaccattaa taagattttg cgcggtgttt 2113621 ccaaggattg gacaaattct tcaatgctgt aagtgccaac aacatttttt ccttttgcct 2113681 cctgtaaaaa ctcctcagtt ttactgcttg atctgttgta aacagaaaca gaaaatcccc 2113741 ggctttcgat atttaaagcc agatttttac ccatgaccgc aagtccgata acgccgattt 2113801 gttgttttga catattctaa cgtcccttct gcaaacgttt aatcatttta aaatttaaat 2113861 taaaataaaa tgatatttat aataaagaaa ttaccataca ttcacccttt ttttcaagcg 2113921 attcagcttt tcttttcatc ttgaaaaaaa tctttattaa agcttgttcc ctttgttttg 2113981 ctctcctctt tttttaacgt tgcccctttt ctgatcagtt tggtaccgta ctttttattc 2114041 agcttttcca tcatctgctg aatgggctca tccttcgcat cttcattaaa gctgaacaaa 2114101 tcgagctgtt tataggcctg ctctttttct actaaatccg ttccggtaat gccaagcagc 2114161 ctgacaggat ttttattcca atgtttaaaa aagaggtgct ccgcttcttt caaaatgtca 2114221 tttttttgat caatcgggtt tctcagcgta gtgcttcttg tgatggttct ccaatccgca 2114281 tatctaatca taataaaaag cttcgaagcc atgacttcct tgcgctgtaa acggtcactc 2114341 acagaagcgg caagctttct aaaaacgcct aacagctctt cttcatcact ggaatcatgg 2114401 gaaagtgtcg atgagttgcc gacgctttta aattcgtaaa tgcgctccgg gtcaaccggc 2114461 gcatggtgaa tgccatttgc tttattttta aggcgcggac cgttgatgcc aagcaggcgc 2114521 ttcagcgagt gttcatcagc tgcagctagc tctccgattg tatggatgcc gagtcccttc 2114581 agtttttccg ctgtcttttt gccgactccg tgcatctctc caacaggaag cggccacagg 2114641 atatcgggca cttgcctctt tcttaagatc gtaattccaa gcggtttttt catatcagac 2114701 gccatcttag cgagaaattt attcggtgca atccctatgc ttgacgggag cagcagctct 2114761 ttttgcagcc tgctttggat ttcttttgcc gtctctagag cgcggctgct gtatggtgta 2114821 tcggtcatgt ccatatagcc ttcgtcgatg gagacaggct ccactaggtc agtatattca 2114881 cgaagaatgg taaacatcgc tcgtgaagag tttctatagc ggtcaaagtt cggcggaaga 2114941 acgatgagct caggacaatg gcgcttcgct tgccaaaccg gcatcgttgt tttgacgccg 2115001 cgcgctcttg cttcgtagct gcatgttacc acaatgccct ttcgctcctt tacgtttccg 2115061 gcaactgcga ccggctttcc ccggagagcc ggatcatatg ccatttcaac cgacgcataa 2115121 aagctattca tatcaatatg gaaaataatt cggctctttc ccggcataaa caaatctcct 2115181 tttcggtcat tagacaacag cttgtacata tagtaaaatg aagctattga atggatgtga 2115241 tgacaatgtt tgtggaatcg ataaatgacg ttttattctt agtcgatttt ttcacaatta 2115301 ttcttcctgc tctaacggca atcgggattg cattcctctt acgggagtgc cgtgcgggcg 2115361 agcaatggaa atcaaaacga acagatgaac atcagacggt ctttcacatt aaccgaacag 2115421 actttcttat tattatatat catcgcatta caacttggat acgtaaagtc ttccgcatga 2115481 attcgcctgt gaacgatgag gaagacgccg gttctcttct tttataaacc gcatttataa 2115541 aaaggaggag aacaaaattg ttaaaaacat atcaaaaact tttggctatg ggtatctttt 2115601 tgatcgtatt atgctcgggc aatgctgcat ttgcagcgac taatcaggtg ggaggcctca 2115661 gcaacgtagg ttttttccac gattatttaa tcgaaccgtt ttccgctctg cttaagggtg 2115721 ttgccgggct gtttcacgga gaatacggac tctctattat cctcgtaacc attattgtgc 2115781 gtatagttgt attgcctttg tttgtcaatc agttcaaaaa acagcgcatc ttccaagaga 2115841 aaatggccgt tattaaacct caggttgaca gtatccaggt taagttgaaa aagacgaagg 2115901 acccggaaaa gcaaaaagag ctgcaaatgg aaatgatgaa gctgtatcag gagcataata 2115961 tcaacccgct tgcgatgggc tgtcttccaa tgctgattca gtctccgatt atgattgggc 2116021 tttattacgc gattcgctca acacctgaaa ttgcgtcaca ctcgtttcta tggttcagtt 2116081 tagggcaatc tgatattctc atgtccctta gtgcagggat tatgtatttt gtccaagcct 2116141 atatcgctca aaaactgagc gcgaaatatt ccgctgtccc gcaaaaccct gcagcgcagc 2116201 aatccgcaaa attgatggtg ttcatcttcc ctgtgatgat gacgattttc tcgcttaatg 2116261 tgccggcagc ccttccgctg tactggttta caagcggact gtttttgaca gtgcaaaaca 2116321 tcgtccttca gatgacgcat cataaaagta aaaaaacagc cgctcttact gagtcggtga 2116381 aataaaaaag caaccccgtg caaaaagccg gggttgtttt ttgttacttg caaagtaccg 2116441 cgccaaacag tcttgtttat catggctgaa gcagaaatgg ccatcctaaa aaatagccgt 2116501 atcgtttaaa aagaaggaaa tcgggaatac ctttactcac ctccaaccga aaggagccta 2116561 tacgttgacg gaacgctttc agcaaaaaaa tatttctgta cctgatggaa tctggatcat 2116621 gagacaaacc tggaatgatg tcttatttgc tcactggcct gttgatgttt ctatccttcg 2116681 cgctttggta ccgtccgttt tagaattaga tacatataac gggcaagctt ggatcagcat 2116741 gcttcccttt atgctcacga acctgagggc gcgttatctc cctgtcattc ccggtgcgcg 2116801 tgcatttcct gagcttaacc tccgcaccta tgtcacgtat aaaggcaagc ccggcattta 2116861 tttttttagc ttagatgccg atcatcgtct ggcggtcctt ggcgctcgca cattctttca 2116921 tctgccttat ttttacgcgg atatgaagtc cgaaaaaaac ggtgatgcca ttgactatgt 2116981 cagcaagcgg aaaaatgaca aagaagcagc attccacgcc gcataccggc caatttcagc 2117041 gccttttaca gcagaaaagg attcgctcga ttactggctg acagaacgat acaggctcta 2117101 caccacttat cgcaataagc tctattacga agacatccat catcatccgt ggctgctgca 2117161 aaacgccgaa gcagaaattt cagtcaatac ggtgactgat gctcacggta ttacattgcc 2117221 ggagtcagac cccttgcttc attatgctaa aaaacaggat gtgttatttt ggccgcttag 2117281 gaaatggagc taaaaaaacc cgatgcggga aatcgcactc gggttttctt tttttatttt 2117341 gccgcctctt caataatggc aacaaccatt tctgccgttt taacgagctc ttcgatcggc 2117401 attttttcat tttttgtatg gatttgctca taaccgacag caagattgac cgtcgggatg 2117461 ccatgaccag cgattacgtt cgcgtcgctt ccgccgccgc tcgtttgcag ctcgcttgga 2117521 cgtccgattt tagcagccgc ttttttcgcg atttcaacaa cttggtcgcc gtcttgatat 2117581 ttaaagcccg gatacataac ctcaatttcg acttctgcgc gtccgcccat atcagcagct 2117641 gcctcttcaa aagcagcttt cattttttga acctgagctt ccattttctc aggaactaaa 2117701 gagcgcgctt cagcaagaat atgaacttcg tcgcacacaa tgtttgtttg tgtgccgcct 2117761 tcaaaccggc cgatattagc tgttgtttct tcatcgatac ggcccaatgg catttttgag 2117821 atggctttgc tagcgattgt aatcgctgaa atgccttttt caggttcaac cccggcgtga 2117881 gcggttttcc cgaaaattgc cgctcttacc ttcgcctgtg tcggcgcggc cacaatgata 2117941 tttccgactt ttccgtctga atcaagagca tagccgtagg atgcagtgat catagaacgg 2118001 tcaagcgcct tcgctccgat cagacccgat tcttccccta ctgtgatgat gaattcaatc 2118061 gtgccgtgtt caatattttc ttctttcagc accttaatcg cctcaaacat tgcagccaat 2118121 cccgctttat catcagcacc taaaatcgtc gtgccgtcag ttttgacgta accgttctct 2118181 acaactggtt ttacgccgtt tccgggtaca actgtgtcca tatgagatgt aaaatagatc 2118241 gtatctgttt gttttgtccc ttttagcgtg caaatcaggt taccggctcc gtggcccgtg 2118301 atatccattg tatcgtcttc tttaacgtcc acacctaaat cagaaaattt tcgtttcagc 2118361 actttgcaga tttcagcttc gtgctttgtt tctgagtcaa tttggacaag ctctaaaaat 2118421 tcttccagca ggcgtttttc attcaccatt tgtaagtccc tccatattaa agcggtatgt 2118481 taccgtgctt ttttttcggt ctctcttctg tcttatgtgt aagcatatga aaagcttgaa 2118541 tcagtcttcc ccttgattct tccggcaaaa tgatgtcatc gaccattcca caagcggccg 2118601 ctttgtatgg gccggcgttt tgctttttgt attcagcagt tttttcgcgt ttcgtctttt 2118661 gcgggtcagc tgaagctttg atttcctttt catacaaaat cgatgccgca ccttctggac 2118721 ccatcactgc gatttcagca ttcggccatg caaacacaag gtccgctccg atcgctttgc 2118781 tgttcatggc cacataggcg ccgccgtacg cttttctaat gatgagtgtg acttttggga 2118841 cagtcgcttc agcataagca aacaataatt ttgctccatg cctgatgatt ccgttgtgct 2118901 cttgctgaat acccggcaga aaccccggga catcttcgac agtcaacagc gggatatcaa 2118961 atgcgtcaca aaaacggatg aaccttgctg ctttatcagc agcgtcaatc gtcaggcttc 2119021 ccgccagatg cttcggctgg ctcgccacga tgccgattgc tttttcaccc agccttgcaa 2119081 acccaatgac aatgttcttc gcaaaaaatg gctgaatctc aaaaaaagac tgcgggtcag 2119141 ccagctccct aatcaccttc cgaacatcat aaggctttgt cgtatcagca gggacaagac 2119201 ggtttaataa cggtctggac gcctctttct ctggcttcgg ctctgttgtc cggccattca 2119261 gcggcaaata agacagtagt tttctcaccc ctgtcagaac ctccttctcc gtatgcccgg 2119321 aaaagtgggc gtttccgctg acggcattat gtatccccgc tccgcctaag ctctccgcat 2119381 caacctgttc ccctgtcact ttttcaatca ccttcgggcc ggtaataaac atccggccag 2119441 tctgttcagc cataaatata aaatctgtga gtgccggaga atatacagcg cctccagcgc 2119501 acggccctaa aataaccgat atttgcggaa tgactccgga atataagacg tttcggtaaa 2119561 atatgtgacc gtatccatct aatgataaca caccctcttg aattctcgca ccacctgagt 2119621 cattcagccc gataatcggc gccttatttt ttgctgccag atccatcaaa gcgcagattt 2119681 tcctggcatg ggtttcgcca agcgcccctc cgtacactgt gaagtcttgc gcaaatacat 2119741 aaactgagcg accgtcaatt gtgccgtacc ctgtcacgac cccatcccct aacatgcgct 2119801 gttctcttgt taacacttga ctttccatga aggggtgtaa ttcgataaag ctgtcctgat 2119861 ctagaagaaa tatgatcctt tcccgagcag tgagcttgcc cttttgccgc tgctgagcca 2119921 gcttttcccg tcctccgcct tcttctgcct gcttgcgttt cgtgtaaaaa tgatccatgt 2119981 gctcattcat gctcattgtg ttggtctcct ttcggttcac aaagctctac aagaacaccg 2120041 tttgtttccc gaggggaaat aaacgcgatc tttttcccgt tcgctccctg tcttggaaac 2120101 ctgtcaatca attgaacatg ctgatcagac aatgcttgaa gctgttcaga taggcagttg 2120161 cacaaaaacg caatatgatg cagtccctgc cctttcttct ccaaaaataa atggacgggg 2120221 ctgtcagctg tcaacggctc tatcagctca agtttgacgc taccagcttg aaaaaaagca 2120281 acattcacct tttgctcttc aaccgtttct tgatgaagaa atgcaagccc caatacattt 2120341 tcataaaagc ttcttgcatc ttttatcgaa aaaacggcta tcccgatatg gtcaagcctg 2120401 ttcattttca tccctgcttt cgctaataga tatcgcttgt ccgcccattc aaaacacgct 2120461 aaaatataga cagattgttt aaggagtgaa aatcatgtct caaaaactga tgaaaagcgt 2120521 tttgatcgtg attttgggag tttttattct ttcaactgta ctctcaggaa tcgtcatgtt 2120581 tctataacga taaaaaagca ggcgccttat tcaatgggaa tatcctgctt ttttatcaga 2120641 gctttatgct cgatggcaat ctcctcaaaa gagcggttgt cgtccgtgat cagcactctc 2120701 gttcctactg gtatcgtttg aaacaaatga acaacctcat cgttatgcat acgtatacag 2120761 ccgttagaca caaattttcc tactgattcc tctcggtttg tcccatgaat tccataaatc 2120821 cgcccgtccg ttcctttcgc gtcaaatccg atccatcttg ccccaagcgg gttatcagga 2120881 gatccccctt caatattttt ctttctgtag taaggatttt ccgcttttac cgttaccgaa 2120941 aactctcctt caggcgtcaa atcatctgtt tttccagtcg ccacactata cacgccttct 2121001 actttgttgt cgaggataac agcaagttca tttgttcgct tgttgacaat aacatacgga 2121061 tcacccggca gcggattttc gccgagcggc caaatcggtg aaatcatcat gaaaatcgaa 2121121 cataagaaaa aacgcataag ctcctccttt ttcattaggt tgaccaatga aggaagagct 2121181 catgcgaatc atccgagtga tttttgcgct tttattcctt taaaataact tttaatcact 2121241 aaatattgtt ccatttcgcc gagaagatgg aagagagcgg ccctcgcttc aaattcctct 2121301 ctagtcgcag gaagcggcat ctcctcaaat tcttttctca tgtcagcaag tcttttcaga 2121361 aatttgtatg ctgtattccc agggtgtatc gcctcccgca aatcatgaat aaattcagcg 2121421 atcatttttc cctgatctac cgtgatggag atcgatgtca ctttagggag aaggcgttcg 2121481 ataatttcaa attgcttttc tctcatttta aaataatgat aatgcagatt ttcataacgc 2121541 aaaatgtggt tttgcacatc tcgatatgcc aggtttttag cctccgtaat gagctggtgc 2121601 gtttccggaa tttcttttcc tgaccaatct tgctcaccag ttaacaaata ccgttcgatt 2121661 tctgcaaaaa tgacagcaaa gttatcctct atctttttgc ggtaggcaat cagtttccgg 2121721 tcaagactag gcatatacaa gttcatcaat agagcgacgc cgatgccaac cgtaatcagc 2121781 tgaacttcat tccagatgaa agtaggcgta atgccgccgg acatgtataa atgaaggata 2121841 ataacagaac tggtgacgat accctcgtta atttttaaca gaaccgttat cggaatgaat 2121901 atcaaaagaa gcgctccgat cacaaacggg tggtagccaa taagctcgaa aaagagataa 2121961 gaaaaagcaa ttgccagaca gcatgccgaa aagcgggccc atgaggcctg aagcgaccgt 2122021 ttttgtgtga tttgtatgca caaaatggtg atgattcctg ctgatgcgaa gttttgcaaa 2122081 tgcaataact ggcttatata aatagccaaa gctgttccaa gcgcggtctt tattgtgcgg 2122141 taaccaattt taaacatgtc ggactccatt tctatttgtt tcttcaataa aaaagaagag 2122201 gcggccagcc ttcttctttt ttatattcta taatattttc tctaaaaagt cctgcgctct 2122261 tttggatttt ggcgacataa aaaattcctt cggattgccg tcttcgacaa tcattccttg 2122321 gtccataaac agcacacggt ctgccacttc ttttgcgaag cccatttcat gtgtgacaat 2122381 caccatggtc atgccggttt cgaccagctc tttcatcacc tgtagcactt ctttgaccat 2122441 ctctggatca agggcggagg tcggctcgtc aaacagcatg atgtccggat tcatcgcaag 2122501 agccctggca atcgcgacac gctgtttttg tccgccagac aaacggtttg gatagtcatt 2122561 tcgcttttca aacaaaccga ctttgcggag caggtcctca gctttctcct gtgcagcctg 2122621 ttttgattct ttttttacat tgacaggcgc gtacatgatg ttttcgagaa ccgttttgtg 2122681 cggaaagaga tgaaaatgct gaaaaaccat cccgatgttt tcccggacct ttaatgtgtt 2122741 ggttttcggc ttcgtaatct ctgtgtcttt tattgtaatg gttccgccgt taggcttttc 2122801 caacaggttt aaacagcgta agaacgttga tttgcctgag cctgaaggac cgatcacggc 2122861 aacaacctca ccctcagcga ttgttgttga aatgtttttt aatacttcgt gtttcccaaa 2122921 tgattttgac agcttttcaa ccttaatcat tggatttcag cttcctttct acagccttgc 2122981 cgataaacgt taaaatcagg acaagcacat aataaatcaa tcccgcgata atgagcggct 2123041 caaggtaatt gtaagtggcg gcgccagctt gatatgcgcg tctcatgaca tcaccaagcc 2123101 cgatgacggt gacgatcgcc gattcttttg ttaacgtaat taattcattc acaattgcag 2123161 gtgatatatt tttgaaggcc tgcggcagca gcagatcctt catcattttt ccatacggga 2123221 caccgagtgc aacagcagct tctttttgcc ctttatcaat ggcattgatt ccggctctga 2123281 taatttccga tacataagcg gcggaattca aagacaatgc gacaaccgca gcccaaaact 2123341 ggtcaatttg aaatccgagc agctgaggaa ggccaaaata gacaatcata agctgcagca 2123401 ctaaaggcgt gcctcggaac actgatgtat aaaaatcagc gatccagata aacgggcgga 2123461 atgtgctgat cttgcataag cttagcacaa taccgagtat aagtccgata atagcagata 2123521 caacaacaat ttttaatgta attgccaagc cttctaatat aaaaggaatt tgggggatcg 2123581 ttgctgaaaa atccaaattc atagcctttg tctccttttc ttacaggaaa aaagtttcct 2123641 attcaataaa aaggctcaac gaaaaagttg agccgctttt ttttacttct cgccagtgaa 2123701 ccattttttc ttcaatttct caagctctcc gttatcttcc atttccttga gcgctttatt 2123761 gaatttgtct gtcagttcac tgtcctttct gaaagcaatt gctgaaccgg cttcttccgc 2123821 tttcgcatca ggaatcacaa agccttgcag gtcatcattt gatttgaaat acccttctgc 2123881 aacaatgtct tcaataatcg cggcatcgaa gcggtcagat ttgatttcct gcaccaaatc 2123941 agaaattctg ttgcggtctt ctgttttaaa accatattcc ggagaaagct ctttcccctt 2124001 ctcttcctga atagagccaa gctgaacgcc aactgttttt cctttcaggt ctttcaaaga 2124061 ttgaatgccg ctgtcttttt tgctgacaat catatggttc gctgtgtaat acacatcgga 2124121 aaaatcaact tgttttttac gctcaggcgt tggtgtcatt cctgacagaa cgagatccac 2124181 ctgttttgat ttaagcgctg taattaagct gttgaagtcc atatcctgca cttcaatttc 2124241 atagcctgcc ttctttgcca gagcttttgc cagctctaca tcaaagccga caatattatc 2124301 tccttcttta tattcaaacg gtttgtaatc cgccgaagta cccataatta attttttctt 2124361 tccgctttct gaacctgaat tgcttgagcc gcacgcagtt aatgcaaagg tgatgcaagc 2124421 agccacaagt aataagagcc attttttcat gatccatttc ccccgtattc attacttttg 2124481 gtgtatttga atatttattc gttaatttgt attttaaaca gtttctcatt tttatgcaat 2124541 actattttta aaaattatct ttaggcttat ctttccagtg atctcttctg atattactag 2124601 ataaaaatta aatcgctgta caatccgatt gaataatccc ttaatattta ttcatatatc 2124661 cttggaaatt tatgcacaaa aaaacccggg ctgctttgag catccgggtt gttcgtctta 2124721 tacttcttca caatattctt caaaggcttc ctgcagcttt gccactacag ccatcggctc 2124781 atggccttca atttcatgac gctctaccat tttcatgatc tttccgtctt tcaaaatcgc 2124841 aaaggacgga gaagatggtg gataaccttc aaaatagtca cgcgcacgcg ctgtcgcttc 2124901 tttatcctgt ccggcaaaaa cggtgacgag ctgatcaggt cttttatcat agtgaacgga 2124961 atggtaggct gccggtcttg caattcctcc ggcgcatccg caaacagagt ttaccatgac 2125021 gagcgtcgtt ccttttttcg taagtgcctc atccacctct tcggctgttt taagctcggt 2125081 gtatccggca gctgttattt cttgtctcgc ttggcggaca atatcattca taaataaatt 2125141 aaagtccatg ttcaatgaag acctctcctt tttcatcatc tgttcttatg atagcaagga 2125201 aacgtccata tcggcaaatg actttgcttc gccgtgcact ttttttgctc ttcgtttact 2125261 gcttacagaa aaaggggatt atataaccag aagtaaaata aaggagcagt tgtatatgag 2125321 ccaccggaaa gcgttactga ttcataacgg aaatgccggc aacaaaaata tagaaaaagc 2125381 acttggtgct gtggtgccgg ttttatctca ccatttagat gaggtgatta ttaaacagac 2125441 aaagaaaaag gatgatgcgt atcatttttg ccgatccatt gatgattctg tcgacaccgt 2125501 cttcattctc ggcggcgacg gcacgatcca tcaatgcata aatgctatca gcgctctaga 2125561 aagaaaaccc gctgtcggaa ttttgcccgg cggcacgtgc aacgactttt caagagtgct 2125621 tggcatccct caaaatcttg caaaggccgc ggaagcactt atggcgggaa aaaaaaccag 2125681 cgtagacgta tgtcagatga atgaccgtta ttttttgaat ttctggggga tcggcttaat 2125741 tgcagaaacg tcgaatcaaa tcaacgaaac ggaaaaagca ttattgggaa aaatcagcta 2125801 ttttacaagt gccttgcgaa ccgtctcatc tgctgcatcg tttccgatga cattaaaaat 2125861 tgatggagaa gaaattaaag aagaagccgt tatgctgctt gtgatgaatg gccaatacat 2125921 tggaacgaat cgaattcctc tgcccgatgc cagtattgaa gacggcttac ttgatgttct 2125981 catatgccgc aataccaacc tcaccgcgct gcgggagctg atgagcatgg aacaaggctc 2126041 aattgatcgt tttactggag agttgtccta tgtccaggct tcccgtatcg agattgaaac 2126101 agacactgcc aaaaaggcgg atatggatgg agaagtttat acacatacac ccgcagtcat 2126161 tcaggtcctg ccacagcata tcgacatgct tgttcccgca aatgaataac tgtcataagg 2126221 ctttagaaag attttgcaaa tccgttgact ctcccctagg aggaggtctt acagtataag 2126281 ggatacacac ttgaaaaagg ggaagtcata tggagaagaa aaatattacc ttaactatat 2126341 tattaaccaa tttatttatt gcttttttgg ggatcgggct tgtgattcca gtaacgccga 2126401 ccattatgaa tgaattgcat ttatcgggga ccgcggtcgg ctatatggtt gcctgcttcg 2126461 ctattacaca gctcattgtc tcaccaatag ccggacgatg ggttgatcgc ttcgggcgca 2126521 agatcatgat cgtaatcggc ctgttgttct ttagtgtgtc ggagtttttg ttcggcattg 2126581 gaaaaacagt tgagatgtta tttatctccc gtatgctggg cggtatcagc gcagccttca 2126641 ttatgcccgg ggtcacggct tttattgcag atatcacgac cattaaaaca cggccaaaag 2126701 cgctcggtta tatgtcagcc gctatttcaa caggatttat tatcggcccc ggcatcgggg 2126761 gatttttagc agaagtccat tcccggctgc cttttttctt tgcggcagct tttgcactgt 2126821 tagcagccat tttatcaatc ctcacgctgc gcgagccgga acgaaaccct gaaaatcagg 2126881 aaataaaagg acagaagaca ggctttaaac gaatttttgc ccccatgtat ttcatagctt 2126941 ttctcattat cttaatttcg tcttttggtt tagcatcatt tgaatcttta tttgcattat 2127001 tcgtggatca taaattcgga tttacggcca gcgacattgc cattatgatt acaggaggag 2127061 cgattgttgg cgccattacg caagtcgtct tattcgaccg cttcacaaga tggtttggcg 2127121 aaattcattt aattcggtac agcttaattc tctcgacgag tctggtattc ttgctgacaa 2127181 cggtacattc atatgttgcg attctgctgg tgacagtcac cgtatttgtc ggatttgatc 2127241 tcatgcggcc tgcggtaacg acttacctgt caaagattgc gggaaatgaa caggggtttg 2127301 ccggcggtat gaattcaatg tttacaagta tcggcaatgt attcgggcct attatcggcg 2127361 gaatgctgtt cgatatagat gtaaactatc ctttctactt tgcaacggtc accttagcca 2127421 tagggattgc actgaccatt gcttggaaag cgcctgcaca tcttaaagcc agcacgtgat 2127481 aagaagcgca ttctttgtgt actgcaaaga atgcgcttct tctttatact gatgatagaa 2127541 ggagtgatgg catgaaggaa tcgtattact caattgggga agtatcaaaa ctggcaaacg 2127601 tgtcgataaa agcgctccgt tattacgata aaattgattt atttaaacca gcctacgtcg 2127661 acccggatac cagctaccgc tattatacag attctcagct cattcatctg gatttgatca 2127721 aatcattgaa atatatcggc acacctttag aagagatgaa aaaagcacag gacttagaga 2127781 tggaagaact gtttgctttt tatacagagc aggagaggca aatcagggag aaattagact 2127841 ttttatcagc cctggagcaa accatttcat tggtgaaaaa gcggatgaaa cggcagatgg 2127901 aatatcccgc gctcggtgag gtgtttgttt tagatgaaga agaaatacgg atcattcaga 2127961 cagaggcaga aggaatcggg cctgaaaacg tgctcaacgc ctcctacagc aaattaaaaa 2128021 aatttatcga gtcagcagat ggatttacga acaatagcta cggcgctact ttctcttttc 2128081 agccctacac cagcattgat gaaatgactt accgtcatat tttcacacct gtattgacga 2128141 ataaacagat ttcatcaatt acgccggata tggaaatcac aacgatccct aaagggaggt 2128201 atgcgtgtat cgcgtataat ttttcgcctg aacattattt tctcaactta cagaagctta 2128261 tcaaatatat cgcggaccgc caattaacag ttgtcagtga tgtatacgag ttaatcatac 2128321 cgattcatta ctccccgaaa aaacaagaag aatatcgagt cgaaatgaaa atacggatcg 2128381 ctgaataata aagcatagaa aaagagcatt ttttgaaaca aaacttcaaa aaatgctctt 2128441 tttgcttatt tagtaaacag atgtcttctc gtcaatcgat tctaaaattt gtttcactcg 2128501 tccgaggaat cgtccgcaca cgagaccgtc aagcactctg tgatctaatg acaggcacag 2128561 attaaccatg tctctgacag caatcatgcc attgtccatg acaaccgggc gtttgacgat 2128621 ggattctact tgaagaatcg cagcctgagg gtagttgata atgcccatcg actgaacaga 2128681 cccgaacgaa cctgtgttgt tgacggtaaa cgtgcctccc tgcatgtcat ctgcagtgag 2128741 ttttccgtct cttacttttt tagctaggcc ggtaatgtct ttcgcaatgc ctttaattgt 2128801 tttttcatca gcgtttttaa tcaccggaac aaataaagaa tcctctgtgg caactgcaat 2128861 tgaaatattg atatcctttt tctgaataat tttgtccccc gcccacatgc tattcatttg 2128921 cgggaattct tttaacgcct gagcgaccgc ttttacaaaa aaggcgaaga acgttaaatt 2128981 aaagccttct gtcttcttaa aagaatcttt tatactgttg cgatatgcaa ccatatttgt 2129041 gacgtcgact tccatcatcg tccaagcatg cggaatttct gttttgcttc gcttcatatt 2129101 ggaagcaatt gcttttctta cacctgtgac agggatttct ttatcaccgg ctgcagacgc 2129161 aggatatgac gtctcttctt ttggctcagg ttttgatgca gacttcggtg caggagctgc 2129221 tgttttcagc tcctcaggat tctgttcttg cacgccgcct gtttcaatta agcgctgaat 2129281 atcttttcgt gtgatgcgcc cgccggcacc agttcctgtc acttgatcga ggtcaatgcc 2129341 gtgctctccg gccaaacgga gaacagctgg cgagtagcgc tttttattgg gctgatcggc 2129401 tgctccagca ctttttgcaa cagggttctc agcggcttct gatgctgctg gctgttcttg 2129461 tttttgttca gccggattcg cgccttctgt ttcaattttg caaatcattt ctccgacttg 2129521 cagggtttgg ccttcttctc ccacaagctc tgttatcgta ccagtaaaag aagacggaac 2129581 ctctgcattt accttatctg tcatgacttc cgcgatcgga tcgtatttgt tcactttatc 2129641 accgggggcg acaagccatt tgctgatcgt cccctctgtt acgctttctc caagctgcgg 2129701 catcgtcatt tgttcaattg ccatgattgt atcctccctt acgtctttaa aactccgcta 2129761 attctctcat cgccgcttcc actttatcag ggttgaccat aaagtatttt tccattgtcg 2129821 gcgcataagg catagccgga atatcaggac ctgcaagccg tttgatcggc gcgtctaagt 2129881 cgaacagaca atgctcggat ataattgcgg ctacttcgct catgatgctg ccttcttttg 2129941 tatcttctgt gaccaaaaga acctttccag ttttggacgc agcttcgatg atggcttctt 2130001 tatcaagcgg gtaaactgtt cttaaatcca ccacatgcgc tgaaatgcca tctttttcga 2130061 gacgttctgc agcttgtaag gcgaagtgga cacacaggcc gtatgtgatc actgtgatgt 2130121 cgtcgccttc cctttttacg tccgccttgc cgattggcag gacataatca tcagccggaa 2130181 cctcgccctt tatcagacgg tatgcccgct tgtgctcaaa aaacagcacg gggtcttcgt 2130241 cacgaactgc ggcttttaag agccctttcg cgtcatatgg tgttgatggc atgacaattt 2130301 tcagtccggg ctggttggcg aaaattgctt cgactgattg agaatgatac agggctccgt 2130361 gcacgcctcc gccgtatggc gctctgacga caatcggaca gctccagtca ttgttgctgc 2130421 ggtagcggat tttagccgct tcagaaataa tttggttgac tgccggcata atgaaatcag 2130481 caaactgcat ttcagcaatc ggtctcattc cgtacattgc cgctccgata ccgactcctg 2130541 cgattgcaga ttcagcaagc ggcgtatcca taacgcgctc ttccccaaat tgttcataga 2130601 gtcccgctgt cgctttaaac acaccgcctt ttcttcctac atcttcccca aggacgaaaa 2130661 cgcgagaatc tcgttccatt tcttctttca tcgccaaatt gattgcatca atatatgaca 2130721 ttactgacat ttgttcttcc tccctacttc gcataaacat aatcaagcgc tgactcagga 2130781 gctgcatatg gggcgttctc cgcttcatcc gtcgcttcat ttacgattgc cataatttca 2130841 tccagcatgg tttgttctat ctcatcggac agcaggcctg tttcctttaa gtaagcttga 2130901 taagtaagca ggggatcact ttttttcgct tcctctactt cttcacggcc tctgtagctg 2130961 ctgtcatcgt catcactgga atgtggtgta aggcggtaag aaatcgtttc aattaatgtc 2131021 gggccttctc ctctgcgtgc cctttcgcgt gcttctttaa ccgcttgata aacttccagc 2131081 ggatcatttc cattcacagt tacgccaggc atcccatagc ctatggcacg gtcggaaatg 2131141 ttctcacatg cgacttgctt atcgtaaggc actgagattg cgtatttgtt gttttcacac 2131201 atgaaaataa ccggcagctt atggacagcg gcaaagtttg ccccttcatg gaaatcgcct 2131261 tggtttgaag acccttcccc gaatgtaaca aaggctgcga tatccttttt ctccatacgt 2131321 cccgcaagcg caataccgac tgcgtgcggc acttgcgttg taaccggaga tgatcccgtc 2131381 acaatgcggt ttttcttttg tccgaaatgt cccggcatct ggcggcctcc tgagttcgga 2131441 tctgctgctt ttgcaaaccc ggacatcatt aagtcctttg ctgtcatgcc aaacgcgagc 2131501 acgacaccca tgtctctgta gtacggcaat acataatcca tttcacggtc aagtgcgaaa 2131561 gccgctccta cctgtgctgc ttcctgtcct tgacaagaga ttacaaatgg aattttgcca 2131621 gaacggttta acagccacat tctttcatcg atttttcttg ctaacagcat ggttctatac 2131681 atatcaacgg cttcctgatc agtcagccct agtgcttgat gtcggtttgt actcattcaa 2131741 gcccctcctt tatgctttta aaaatgaatg gctttgccat ctgcggcaag cgcagcttct 2131801 ccaattgctt cagaaagcgt tggatgcggg tgaatcgttt gcccgacctc ccacggtgtt 2131861 gcgtccagca ctttggcaag acccgcttca gaaatcatgt cggtgacatg cgggccaatc 2131921 atatgaacgc cgagaatatc atctgtatct cggtcagcca cgattttgac aaaaccgtcg 2131981 ctttcaccgt atacaagcgc ttttccaatc gccataaatg ggaacttgcc gattttgaca 2132041 ttatgcccgt tcgcctttgc ttcgtcttcg gttaagccga cactggcagc ttcagggctt 2132101 gagtaaatgc acttcggcac aagcgtcgga tcaagcggat gcggattgag acctgcaaaa 2132161 tgctcaacag caataattcc ctcatgtgaa gcaacgtgag ctaactgcag gccaccgatt 2132221 acgtctccga ttgcataaat atgagattcc ttcgtttggc agctttcatt gactgaaatc 2132281 atgccatttt cagtaacaat atcggtgttc tctaggccga tgccttcgat atttgcctgt 2132341 ctgccgatgg aaacaagcat tttctcagca gaataggtaa cggtttctcc gtctttttcc 2132401 gcttgtatgc tgatatcgtc tgatgttttt gtcattgtgt caggcagcac ttttgcccct 2132461 gttatgaact ggatgccttt tttcttaaga agactttcca tttcttttga aatctctaga 2132521 tcttcagtcg gcaatatgcg atccgcgtat tcaataaccg ttaccttaac gccaaaatca 2132581 tgaagcatag acgcccattc gataccgata acccctccgc cgacaatgat gattgactgt 2132641 ggcagctcct ccatttggag cgcctcatct gaagtcagta cagacttacc gtccacttca 2132701 agacccggaa gcattctcgg tcttgatcct gttgcaatga tcacttgttt cgggatcagc 2132761 atgtcatttt cttcgccatt tccccgctca acagaaattg ttcccggcag cggagagaag 2132821 attgacggtc caaggatacg tccatatccg gtgtacacgt caatttttcc ttttttcatt 2132881 aaatgattta cacccgctgc aagcttatca acaacggctt gcttacgctg ctgcactttt 2132941 tcaaagttga gggacacgcc agccgtttcc actccgaatt gatcggcttc acgagctgtc 2133001 cggtatacct ctgcgcttct aagcagcgct ttactcggga tacagccttt atgcagacat 2133061 gttcccccga gtttttcctt ttccacaacg gctgttttta agccgagctg agcggctctg 2133121 atggccgcaa cataaccgcc ggtaccgccg cccagaatga ctacgtcata ctcagttgcc 2133181 atggtgactc actcctgtct gtctattcaa tacgatattg tttggattgc tcttcgccct 2133241 gcaatactct tagcgcccct tgggcaagag actgcagttc attttcaccc ggataaacta 2133301 aaacgtctga aatccaatct atgtatgatc tgatagcaga aacaaagctt tttccgtacg 2133361 caaggcctcc cgtcagcaca atcgcttcaa cttcgccttt taacgccgcg ctggctgccc 2133421 cgatttcctt tgctacctga tatgccatgg catcataaat gaagcgggct ttttcatcgc 2133481 ccccttgaat catctgttcc acttttactg catcatttgt accgagatag cctaaaagtc 2133541 cgccggtgcc aacaagcttt ttcatgattt cttcttttgt atattcccct gaaaaacata 2133601 gatcaacaag atctcccgca ggcactgttc ctgctcgttc aggactgaat ggtccctcgc 2133661 cgtgcaggcc gttattgaca tccaccactc gcccgcggtc atggacgcca attgtaatac 2133721 ctccgcccat atgggtaata atcattttca tgttctcata tcgtttgcca agggaggctg 2133781 ccgctttacg agcgacagct ttttggttta acgcatggaa aatgcttttc ctttcaattt 2133841 caggcatgcc tgaaactttc gcaagcactg acatttcgtc tacgacaaca gggtcgacga 2133901 tatacgaagg gatattcagg ccgtcagcga tttcccgcgc gataatgccg ccgagattag 2133961 aagcatgctg accggcgtag ccgcttttca aatcctcaat catctcatca ttcactacgt 2134021 aggtcccgcc ttcaattggc cggagaaggc cgcctcttgc gcagactgca tcaaactttg 2134081 aaatattgat tccctgttca tgaagcgttt cgagaatatg gtttttacga aattcatact 2134141 gatcaataat tcggtcaaat cgctgcagct cttctatgtt gtgtctcaat gttttttcaa 2134201 aaatgcttct ttcgttatga aaaacaccga ttttcgttga agttgagcct ggattaattg 2134261 tgagaatgcg tttttcgtca tgtagcactt tcataacctc cagatcaatt tcttaacgtc 2134321 tgcttaatac actgtggccg ttttgcaaaa actggcttct tgagcggcgc atgcgttcaa 2134381 tccgttcctc tgctaagcgg tcagccgcta aatatgcagg aatgccgtca cgctgagaaa 2134441 tctcaagtac acgctcgata ttgccgtaaa tgccttcaac ttttttcaat gcacgttctg 2134501 cattatagcc gtaaagctca tctgccacgt tgatgacacc gcccgcgtta atcacgtaat 2134561 ccggtgcata aacgatgccc atttcgtgaa tttgatcacc atggcgtgtc tcttttaatt 2134621 ggttgttagc cgcacctgcg atcactttcg ccttcagctg tttaatggtg tcgtcgttaa 2134681 tagtcgcacc aagggcacac ggcgcataaa tatcgcagtc ttgtgaataa atgtcatcag 2134741 gatctaccgc acgggcgcca aaatcttcaa ctgcacgctg tacagattgt ttgttgatat 2134801 ccgtaacgat taagtttgct ccttcttcat gcaggtggcg gcaaaggtta taggctacgt 2134861 tcccaacacc ctgtacagca atggtttttc cttcaagaga gtcggttccg aaagcagctt 2134921 tagctgctgc cttcattcct ctgtacaccc cgtacgctgt gactggggac ggatttccag 2134981 aagagccgaa agcaggagaa atccctgtga catagtctgt ctcatcatga atgatatcca 2135041 tatcctcgac cgttgtgccc acatcttcag ccgtgatgta tctgccattc agtccttgaa 2135101 tatagcggcc aaacgcgcgg aacatttcct catttttgtc tttgcgcgga tcgccgataa 2135161 tgactgtttt tccgccgcca aggtttaagc ctgccgccgc gttcttatag gtcatgcctc 2135221 ttgccaatct gagcgcatct tcaattgccg cttcttcatt ttcatatgtc cacattctcg 2135281 ttccgccaag cgccggacca agcgttgtat catgaatggc gataatcgct tttaatccag 2135341 attgttcatc ctggcagaat accaattgtt cgtaatcgta tttctccata tatttaaaaa 2135401 gttccatgtt cgttcctcct aatgtgtgta ttcttcagat gcgcatattg ccagcgcaat 2135461 ggaatacagt ttattttcag cagagtccgc tctgcttgtt aaagcaatcg gtgcttttgc 2135521 tcctgtaatg acagccgcca cgctggcctt ggcaaaataa atcagtgatt tatataaaat 2135581 attgccggcc tcaattgttg ggacgagaag gatatctgcg ttgcccgcta cgtctcccga 2135641 aatttttttc tgggccgcgg caatttgtga aactgcgtta tccaaagcaa gcggtccatc 2135701 aacaatgcag cctttgatct ggcccctttt gtacatttga gctagagcag ctgcattcac 2135761 ggtcgcttcc attttagggt tcaccgtttc gaccgctgca agggcagctg cttttggcat 2135821 attgttcccc actgcatggg ccacatgaac ggcattttgc aaaatctgcc ggagctcttc 2135881 cagcgaagga gcaatattca ttgccgaatc tgtcacaaac atcagccggt caaaatccgg 2135941 tatatcgaag acagccacgt gagaaaggac acttgctgac cgaagcccct cctgtctgtt 2136001 caataccgct ttaagcaaaa cagaagtcgg cacattgcct ttcattaaaa cgtccgctgt 2136061 tttatgatgc acagcacgaa ccgctaattt cgccgattcc tcaggagtat tggcatggac 2136121 gatttccact tgatgccctt gcatggatga tgtcagctcg ttcagttttt tgctgtcgcc 2136181 cgttaacaag aaacgggcgg ataggtgctc ggctgccagc tttacagccc ggatcacttc 2136241 ctcatcctca gcatgagcaa ccgcaatggt cttatttttg tgtatcgacg ctttgccgat 2136301 taaatctttc agcttcatct gttaccacct ttcttgtttc gactccgcct tttattatgc 2136361 aagttccatg ccagctctta agggtgctgt cataccaggt ataccgaaac attcgtgcag 2136421 atgtttgcgt ttattctgca aattattgca tgccttcatt tgcaaggcca tatttatcca 2136481 ttttgtaata taaattccga atgctgacac cgagagcttt tgctgttttt gtccggttaa 2136541 aatgatgctt ttcaagcgtt tgctggatca aatgcgcttc aaatttttct actgcgacag 2136601 acagcttttc gccttcaata tccggaaaat caaaacctgt tccctgatct gtgtcatttt 2136661 ctttttgctc aagttcgaat acaggcaagt gatctttttc aatccattcc atatgcggat 2136721 tcagaaaaat catggctcgt ccaaggacat tttcaagctc ccggacattc ccaggccaat 2136781 ggtaggcaga taaggcgcgc aaggcttgct gtgagagccc ttttacattc ctgccgtaat 2136841 cccggttgat cttttggata agtctgacgc tcaatgcttc aatgtcctcc aaccgctgcc 2136901 gcaaaggcgg gatggagatc ggatagcgat tgatccggta atacaggtct tcccggaatg 2136961 ttccgtccgc catcgccttt tcaatattta catttgtcgc cgcgatcact ctgacgttga 2137021 cagggatcgc tttcgtgccg cccactctga cgatttcctt ttcttgaagg acgcgtagca 2137081 atttggcctg catattttgt gtcagctcac cgatttcatc taagaaaata ctgccgttat 2137141 ttgcttcctc aaataaaccc tttttaccgc cgcgcttcgc tcctgaaaac gcaccatcct 2137201 catagccgaa caattctgat tcgagcaggt tttcagaaag ggctgcacaa ttcacgcgaa 2137261 taaatttatt gtatttccgg tcactttcgt tatggatggc atgggcgaac agttcttttc 2137321 ctgttcctga ttccccgcgc agcaagatgg ttgccggtgt tttcgcaccg agcttcgcct 2137381 gctcaagcgc aaccagcatt tgctcgcttt tgccgataat gtcgtcaaac gtgtatttcg 2137441 cttcaagcgt gcgaataatt tgtctggcgc gattaagctc cgctgtcagc attttaattt 2137501 cggaaacatc gtgaatcacg ccgacgctgc ctttcaaaat cccgtccaca atcaccggtg 2137561 ctacattaac gatcacttct ttttcattcg ggccgacctt cattctgaca ccgcggacag 2137621 gacgtcttgt ttcaagcacc tttaaatgca tgctttcgcc ttcggaaata tcagtgtttg 2137681 caggcttgcc gatgacttct ttttcagaaa gccccgtcat tttcgtatac gctttattga 2137741 ttagcaggcc gatgccgttt tcatcaacga cagaaatcgc ctcatcggag gattgaataa 2137801 ttgcctccag catcgtacgg acctgcttta agttggtcac ttcctctgcc agctcgaccg 2137861 catcagtgat atctttaaac acacaaagag ccccgagcag acgtccgcct tcatcaataa 2137921 tcggcagtct tgtggtcaca atttgcaaat gatcgcctaa cagctgcttc tggttgtatt 2137981 caggcactct tgtttttaaa atccgcggca tcttagtgct cggaatcact tcttttattg 2138041 ggcgcccaat gacttcctca cgtttttttc cgaccatttt ttcggccata tggttaaaga 2138101 gaatgatttc ttcattgata tcaataaaaa tcattccatc atgggtggaa ttaaaaattc 2138161 tgtcatattt ataggtttgc tcttttagca tttgaatcag gtgctgcttt tcttccatca 2138221 gctgaaaaac gatgtatgcc atttttcccg gcatgacaat ggtatcttca tgctttcttt 2138281 gaaggagctc gtcaaacacg gcttgatcgc cggtagtatg aatgacgata tccggttttt 2138341 gttgtatgta aggtttccaa tcagatgata cggcaatccc atactgttct gcttctttca 2138401 atcccggcgc ctcggggtct ttgtcaacta cggcaatgat atctatgatg gctgttttaa 2138461 tcagaatatg taataacgcc gttccccttt tgccggcacc tactatcagt accttttgca 2138521 tcccgatacc cctttgtatg aaaaaatttg cacacctatt tattccgttg caataatttg 2138581 cacaacccta tgttaccacg ttttcttctc ttgacaaaat attttttccg ctggacaata 2138641 aaggaaatga aaagataaag gggttttctg aagatgagcc gacttcttgc gcttttaata 2138701 ttagtcatcc ccggggctat ttctgcttta ggcattaaac tgatgagaga tacacttttc 2138761 ggccatacaa tcaagccatt ttcagctctt tggctccaag ggttgtcagg attcatcttt 2138821 tttgcgatcg gcctctatgt gctggccggg ttcattttat acagagacag aaaacgcaat 2138881 caagtcagcc cgcgattcag aaaacgatag ctgaaaaaaa gccggagaat gctccggctt 2138941 tttttgttgc attattcgtc aggcaaaacg gtcttggcaa tcgttttgtc taacgcttca 2139001 tagtcataat aagaaatcgt atcgtacagt tcttttcgtg tctgcatatc atgaagtcct 2139061 tctttttgtg agccgtgctc cttcatcaaa ccaaacatcc gctcacaagc ttttgccgcc 2139121 gctcgaagcg aggtgacagg atatatcacc atgtgaaacc ccatatcttc gaattcatcg 2139181 gcacgataat atggcgtttt cccaaattca gtcatattcg caaggagcgg aacggggata 2139241 cgctcagcaa actggcggaa ttcattctcc gcctgtagcg cttccgggaa aattgcgtcc 2139301 gctcccgcct caatgtaagc ctctgaacgt tttattgcgg catcaagccc ttcctgcgcc 2139361 ctggcatcag tacgggcaac aacaataagg gagggtgccg cttgtttaat ggcttttatt 2139421 ttttgcgcca tttcctttat cggaactagc tgtttgccat ttaaatgtcc gcattttttt 2139481 gggagctgct ggtcttccat ttgaacggct gctaccctgg cttcaagcat ctcccgggct 2139541 gttcgggcgg catttaagac accgccaaat cccgtatcga tatccacaag caaaggcaga 2139601 tcagctgcac gcacaagatc tttggcccgt tcagctatct ctgccgatgt gatgatccct 2139661 aaatcaggca gccccctgct ggctgtatag gcagcaccgg acaaataaat agcagaaaaa 2139721 ccggcttctt tcgcaagcaa agcggccatc ccgtcatggg cgccgggaat ttgaagaatg 2139781 tccggtgctg acatcagctt gcggaaacgc ccggcaagct cctcttgtga cgattgctta 2139841 ttgacgatcc acgacatgaa acaaaatccc ccttttacat gcagaacatg tctacgaatt 2139901 catttacgcg catcgtttgt aatgtctcat agctggtaca gcgctcataa atgtgtttgt 2139961 gctgtttatc aggaaaatgg gttttgagat tgtcagaaaa cttttccagc agtttcggca 2140021 ctgcttcctc tcttcgaaaa cgatggccga ggggaaactc acattccacc atttccgtgc 2140081 tcgttccatc tttaaaatga acctgaacgg catttgagat ggagcgttta tcaggcttca 2140141 aataatcctc ggtatatgtt ttattttcag tcacttccat tttatcacga agtttatcta 2140201 ttctcggatc attcgctgtt tcagcttcat aatgctgtgc ggtgatatca ccaaaaagca 2140261 aaccgattgc tgtaatgtat tggaggcagt gatcacggtc tgccggattg tggagcgggc 2140321 cttttttatc aatgattcgg atagctgatt catgcgttct gatgacaact cggtcaatct 2140381 cgtcaatccg gttctttacc tgcgggtgaa gaatgacggc ggactccgcc gctgtctggg 2140441 cgtgaaattc cgcaggataa gacactttaa ataacacatt ttccatgaca taagcgtcga 2140501 gcggacgggc aagcttgatc tctttcttat tgaataaaac gtcttggaac ccccaacccg 2140561 gtgcactcaa ggctgtcgga taacccattt ccccttttaa cgacatcagc gccaaatgaa 2140621 cacctctgct cgttgcatct cctgccgccc atgatttacg cgagcctgta ttcggtgaat 2140681 ggcggtatgt cctcaatgct gcattgtcaa tccatgcatt cgaaagcgca tttttgattt 2140741 cttctcttcc gccgcccaaa agctttgctg caacagcagt tgtcgcaact ttgacaaaca 2140801 gcacatggtc aaggccaact cgatttaagc tgttttctaa cgccagcaca ccttggatct 2140861 cgtgtgcttt gatcatcatc tcaagtacgt cgcgtaccgt taacggctct tttccttcag 2140921 acagcctcac tcttgataca taatcagcag cggcaaggat tcctcccaag ttatcggatg 2140981 gatgccccca ctccgccgcc agccacgtat cgttgtaatc gagccagcga atcatgcagc 2141041 caatattaaa cgctgccctc acaggatcga gaacatatga cgttcccggc actttgcttc 2141101 cattcggcac agtcgttcct ggaacaatcg ggccaagcag ctttgtgcat tccggatacc 2141161 gtagcgccaa gattccgcag cccagggtat ccagcaatac atgccccgct gttgtatacg 2141221 cttcggcact agtaatctct ttctcaagca catagtctgt gatttcttcg ataacacgat 2141281 ccgttttcgg cattctacca gctcctttca tgattttgtt tgatatcgcg ggcccatgta 2141341 actgacacgg ggacggaaga gccgattatt ggcatgctgt tcgatcacat gggcgcataa 2141401 accggacgtt ctcgcgctga aaaagatcgg cgtatataaa ggaatcggta tgccgagcat 2141461 ccaatacact ggggcagcat agtaatccaa attcgggtaa agcccttttt ccttctccat 2141521 cagccgctca cccgcttcgc acatctcata taaacgatgg tcaccggctt tatcgcataa 2141581 ttgctgcagc gcctctttca tcatgagtgc tctcgggtcc atttttttca tatacacccg 2141641 gtggccgaag cccatgattt tttcttttct tttcagtttt gtttgcaaaa gctgctcaaa 2141701 atcagatgtc gtttttgcct ccaaaagcaa atacatcaca gcttcgtttg ctcctccgtg 2141761 aagattccct ttcagggaag cgacagcccc agtcaaagcc ccataaagat ctgaatgtgt 2141821 agatgcaatg accctggccg caaaggttga attcggcatc tcatgctcac tgtacaggac 2141881 gagcgaccgg tcaaaaatct gttcttccaa tgaagacggc aatttccctg tcatcatgta 2141941 gagaaaattc gcactgtagg atagggtttg aagcggaaga atcggttctt tcttattaat 2142001 gatcctgtag ctggcagcag tgagggcagg cattttccca agaagctgat aggcgcgttc 2142061 tttgtttgcg gaaggagacc gatcatcaat ttgccgatca tagccagcaa gtgccgacag 2142121 gccggtacgc agaccatcca ttggatgagt gtcctcaggg agcagctcaa gcagacggag 2142181 atgatcagca ggcaggcttg aggcactgtt tattttacgt tccagcgttt ccatttcact 2142241 ttcttctggc agcctgccct ccagcaataa atggacaagc tccagatagc tttttgtttc 2142301 agaaagttct attaaatcat agcctcttat caaaatctgg ctggactgcg tgtcaagata 2142361 agaaatatga gtttctgccg caatcacacc gtccaaccct ggagaataat gctgtttctc 2142421 ctccatatcc tcaacctccg tttttgcgtt ttttgtctat caggttccgc caagcaaata 2142481 cttggaaata atcagtcttt gaatctcgtt cgtcccttca taaatttgcg tcacctttgc 2142541 atcgcgaagc aggcgctcaa ctggataatc cttcatatag ccatatcccc cataaatttg 2142601 aacggcgtct aacgccgcct ttacggctgc atcggaagca aattgtttag ccatagacgc 2142661 ttcttttcca cagtttaggc cgcggttatg aaggtctgca gcgtggtaga caagatgtct 2142721 tgccgcctca gctctagtcg ccatatcagc cagcttaaat gatatgcctt gattggctgc 2142781 aatcggcctt ccaaattgca ctcgctgctt cgcataatca acggcatgct caagagccgc 2142841 ctctgcaatt ccgagggcct gtgccgcaat gccgatccgg ccgacattta aattcgccat 2142901 ggcaatgtga aagccatccc cctctttgcc aagcaaattg gcttcaggca cttctgcatt 2142961 atcaaaaatc agttccgtag tattggagcc ataaagcccc agctttcttt ctttttttcc 2143021 aacggtaaaa ccgggtgtgt ttttttcaac aataaaagcc gaaatcccgt gcctgccttg 2143081 atctggagct gttaaagcaa atgtgatata gatatcagct gctccgccat tcgttatgaa 2143141 tattttcgat ccgtttaata ggtatttgcc gttctttttg attgctgttg tgcggaggct 2143201 cccggcatcc gaccccgagt gaggctccgt tagtgcaaat gcgcccaaat ggtctcctga 2143261 cgcgagattt ggtatatatt tcatcttctg ttcttcgttg ccgaaataca gaatcggatt 2143321 cgtgccgact gaggtatgaa cggagagaat cacgccgaca gccgcgctga ttctagaaat 2143381 ctcatgaatt gccaaaatat aagaaacaac gtccgctcca gcaccgccgt attgttccgg 2143441 caccggtatt cccatcagtc cgtgtttacc catttttttg atcagctgaa agggaaattc 2143501 gtccgttttc tccatgattt ccgcagcggg agcaatttct tttcgtgcaa aatcacgcac 2143561 catttttcgc atcatgactt gctcttgggt tacatgcaac tcggccaccc ccggatggaa 2143621 tagacttcag gaagtcttct cctcatagtc ataaaaaccg cgtccgctct ttttgccaag 2143681 ccagcctgct ttgacatact tgcggagcag cgggcaagga cggtatttgg aatcgccaag 2143741 gcctgagtga aggacttcca taattgataa acacgtatcc agtccgataa aatccgctaa 2143801 tgcaagcgga cccatcggat gattcatgcc cagcttcatc acttcatcta ttgcctccgg 2143861 cttcgccact ccctcataca cgcaatagat ggcttcatta atcattggaa gaagcacacg 2143921 gttggaaaca aacccaggaa aatcattgac ttctaccgct gttttcccca tcttttccgc 2143981 taatgccata acatctaagg ccgtttcttc tgatgtagcc aagcctcgaa tcacttctac 2144041 cagcttcatt acagggacgg gattcataaa atgcatgcca ataacccgtt gaggccggtt 2144101 tgttacagca gcgatttctg taataggcaa ggaagatgta ttgctggcca aaatcgtatg 2144161 aggcgggcaa atgcgatcaa gtgttttaaa catctcagtt tttgccgcca tgttttctgc 2144221 gatagcctca atcacaatgt ccgcatgctc tgcctcctca agtgtttgag aaatcgaaat 2144281 gcggttgatt acgctcttca cttccgtctc ggtccttttt cctttctcag catcacgggc 2144341 cagctgtttc ttcagccgtt tcaatcctgc ctccgcggcc tctggattca catcatacat 2144401 ccgcacataa aagcccgcgt cggcggctgt ttgagcaatt ccgctcccca tctgacctgc 2144461 gccagctacc atgatttgtt tgatttccat tcaaatcccc tttttcatca tgttttaatg 2144521 aacctgcact aagacggcgt ctccctgtgc tgccccgctg caaatagcgg caacgcccag 2144581 accccctccc cgtcgcttta attcataaac aagcgtcatg agaattctcg caccgctcgc 2144641 gccgatcggg tggccgagcg cgatcgcacc gccattcaca tttacttttt caagatcgaa 2144701 acctacgatt ttttcacatg tcaaaacaac tgaagcaaaa gcttcattta cttcaaacaa 2144761 gtcaatatct tggacagtta aaccattctt tttcaggagc ttgttaatag caaaccctgg 2144821 cgctgccgcc agctcgtgcg ctggcattcc cgtagttgaa aaaccaagaa ttgtagccag 2144881 aggccgtttg ccaagctcag cagctttttc ctcagacatc agcacgaacg cgccggctcc 2144941 gtcattgact ccaggagcat tgccggctgt gatagaaccg tcacttgcat aaatcggagc 2145001 aagttttgcg agctgatcca gacttgtgtc acggcgaatc gcttcatctt tatcaacaac 2145061 gtttggtttt ccttttcgac cgatccagtt gacgggaaca atttcatcct gaaacttccc 2145121 ttcatcggcg gccttagctg cccttgcatg acttctcaac gcccattcgt cctgctctct 2145181 tcgtgagatt gcatattcct tggcagctgt atttccgtga acagccatgt gcacctcgtc 2145241 aaatgcgcac gttaatccgt catacaccat taagtcccta agctcgccgt cccccatccg 2145301 tgctccccag cgcccggcgg gaacggcata cggaatattg ctcatgcttt ccatcccccc 2145361 cgcaacaagt atgtccgcat cctgcgcccg aatcatttga tcacataaag tgacagcgcg 2145421 aaggccggaa gcacagactt tattcagtgt ttctgacggc acactccaag gcattcccgc 2145481 cagacgggca gcttgacggg aaggtatctg ccctgagccg gcctggacaa ccatgcccat 2145541 gacgtttcct tctacatcat ctccagagac tccagcctgt tgcagcgcct ccttcatcac 2145601 aatgccccca agctcagcag ctttcacctc tttcaaaact ccgccgaatt tgccaaatgg 2145661 agttcttgca gcacttacaa tgactgtttt cctcatggtt tcacctcatt cagaagatag 2145721 acagcgctta caatttctag ttgtcttcta tgaatgtatg ctttgaaacg ggcatgaatg 2145781 aatgaaaaaa gaaggctgcg tcaaacagcc tccttctaac aactattcat ttttcagcaa 2145841 tgccgaagcc ttttctggaa agtcggtaaa catgccgtct gctcccgctt caatgagacg 2145901 cttcatatct tccggacgat tgactgtata cggccttacc ttaatcaaac cgttcctcat 2145961 tttcttcagt acttcatctg tgacccctgg gctgtttatc ttcgggtgat agccggaagc 2146021 cggaatagac gcgatatatc gatctgcctg ataaagcaca tctgaagtta atactgcccg 2146081 ttcgatatgc ggtgcaagcc gggcgcacag cgccaagctg tcatgattaa acgtggatag 2146141 gatgactctg tcctctacat taaatcgctt cactgcctcc agcacttttt cttccattcc 2146201 ctcatagcgg atcacgctgt tttttaattc aatgttgatg agaaaatcct tttttaccgc 2146261 ccacgagagc acatcttcta gcagcggcac ttttatatcg ctgtacgctt gatcgtgacc 2146321 agcggccgca ttcgcagtct ttacctcatc ataggctgta tccttcacga atcctttaag 2146381 tgatgtcgtg cgattaagtc tttcatcatg aattacaaca atgcgtccgt ctttcgtcag 2146441 ctgtacatca agctctatcc catccgctcc ggcttcaatt cctttttcaa atgcaagcat 2146501 tgtattttcg ggaaattgac ctgatgcccc ccggtgggca aaaatctttg tcatcgtttc 2146561 acctcaaacc ctaaagtttt ctccattata cttattttgt cggctccact ctaggattaa 2146621 ggctgtatca atctactgat cataataaga atcaatgcca ttgacaatcg catctgcggc 2146681 cttttgctgg tattcttcac ttcccagctt gtccgcgtca gagctgttcg tgataaaccc 2146741 aagctccgcc aacacacttg gcatttgtga atatgtaatg acgtaaaagt ctgattcttt 2146801 cacgcccctg tctctcgttt gtaaggaaga aacgagctgt gactgaatat cggatgccag 2146861 acgccggctg ttctcccctt cataatcaga ttgaaaatac gtttctgttc ctgaagctga 2146921 agcaacccct gaattcacat gaatgctgac aaaaaggtca gcctgattgg cacttgcctt 2146981 agccactctt tcctccaagg tcagaaaatg atcgtcagac cgggatgcaa caggattggc 2147041 tccctcctct tttagtttgt ctgtcacatg ctctgagaca gccaaattaa tatccttttc 2147101 aaagagcccg tttccgaccg ctccactgtc ttcaccgccg tgtccggcat caatatacac 2147161 tgttttccct tctatcggct ctgctgcctg tgcacaaggc gcgagcgtca aagccaatcc 2147221 gcacagcgcc aagctcctcc ataacattct caacttactc cctccggtca cgagttcttt 2147281 cgcagctgaa tatcttccag ctgtaaagtt ccattatcct tctttgtata tttcaccagg 2147341 acatgtgtct gatctggcag tgattcacat tcatcacgtt tatccttcgg aacttgtatc 2147401 atggtttctt ctccattaag agaaaccgca atcgtatgag gatcagccga gccaatgtat 2147461 tttccctctt cggtaaacct cggcactgag tcatccgcac ttgcaacact gcaccccgaa 2147521 agaaagagcg cagtaaacag caaaagaacc gtttgtttca catgaccacc tcttcctgat 2147581 gtttggcttt tatctttgac cagaatggag aatttgtaaa gacaacgcga atgcaggcga 2147641 gcaagttcca tgattttcaa aagggctata cgacccgatc atttcctgtt gttagaaaga 2147701 taacgagcag atttgtctat gaggatggct ctaattgagg cgccaattag aaaaaattag 2147761 cggaaagaag caacttttta ttcattttaa aaaatttgag aatagggtga gcaaatcgtt 2147821 tgacgggtgg gtcagccaag cgtaaccttt taaaggatat ttactttatt gaaagaagtt 2147881 aaagccatga aaaaattcgt tctgctgctg gcggcagctg tcatcacatg ctccatcggc 2147941 caccaaatca gtggcggcta caaaggcccc gaaaaagagc ggccaaaaca tcactctgca 2148001 ctcaagatat tcagtcggta aagcagatca attgcattaa tttttacata taggctagaa 2148061 tatgtgcgaa tccaaacgaa agaagatgat caaatgaatc ctaagtataa gccacttttt 2148121 gaaccattta cgtttaaaag cggcgttaca atcaacaacc ggatcgcagt agcaccgatg 2148181 actcattacg cttctaatga agacggtaca atatctgaag cggagctcga ctacatcatc 2148241 ccccgttcaa aagagatggg aatggtgatt acagcctgcg caaatgttac accggacgga 2148301 aaagcattcc ccgggcagcc ggccatccat gacgattcca acattccagg tttaaaaaag 2148361 ttagcacaag ccattcaggc acaaggcgct aaagctgttg tacaaattca tcacggcggt 2148421 attgagtgcc cgtctgagct cgttcctcaa caggatgttg tggggccaag tgacgtgttt 2148481 gataacggca aacaaattgc tcgcgcatta acagaagaag aagtggaaaa cattgtgaag 2148541 gcgtttggag aagcgacaag acgcgccatt gaagccggct ttgacggtgt cgaaattcac 2148601 ggtgcaaacg gctacttaat tcagcagttt tattctccga aaaccaacca gcgcacggat 2148661 cgctggggag gaagcgatga aaaacgatta gccttcccgc tcgctattgt cgatgaagtg 2148721 aaaaaagccg cttcagaaca tgcgaagggt gcattcttag tcggctaccg cctgtctccg 2148781 gaagaacctg agacaccggg attgacaatg actgaaactt atacgcttgt tgatgcttta 2148841 ggggataaag aattggatta tcttcatatc tcactgatgg acgtgaactc aaaagcgcgc 2148901 cgcggtgcag atccgactcg cacacgcatg gacttattga atgaacgtgt cggaaacaaa 2148961 gtgccgctga tcgccgtcgg ttccatccat tccgctgatg acgcgcttgc cgtcatcgaa 2149021 aacggtattc cactggtcgc tatgggacgc gaaattctag ttgaccctaa ctggacggta 2149081 aaagtaaaag aaggccgtga aaagcaaatc gaaacagtga tcaaaggcac agataaagaa 2149141 aaatatcatt tgcctgaacc gctatggcaa gcaattgtga acacacaagg ctgggtgcct 2149201 tataaagatt aatgtgcaaa gactgccgaa acgattcggc agtctttttt ccctttatat 2149261 aaatagtttg tgtacacatc taaacagcaa aagaaagagc tccccaccaa cttcgaaaag 2149321 aaaatccagg aaaaacccct cacgctttct tgcttttttc tttttcattc gtacgtctcc 2149381 tttttacatg aatacgcctt acttacgatt ttgcaggaga aaggtttcat tttataacgg 2149441 acacatctag ggtcgatcat gcttcgtgat cctataagat gtatgaatgg accaagagtg 2149501 caggtaatac cgccatttgc tttccttact tttcaaacct atcctttact atatgcggat 2149561 acttaatatt cttctcccat actacaaatg tccccaaaac aaaacgcctc ctatttatca 2149621 gcgcaaacta ataaataaaa gacgtttgat ttaatgacca cttaataagc tcatgtttaa 2149681 gaagccttat gctctaacct cagcttatcc gcaaccattg caatgaattc actgttggta 2149741 ggtttagctt ttgtcatgct gacagtataa ccaaacaacg aggaaatgga atcaatgttt 2149801 cctctgctcc atgccacttc aattgcatgg cggatcgctc tttctacacg gcttgcggtt 2149861 gtgttaaatt ttttggcgat gtccggatag aggacttttg taatgctgcc gagcaattcg 2149921 atgtcattgt ataccattga gattgcttcg cgcagataga gatagccttt aatatgggct 2149981 gggacgccga tttcatggat aatgcttgtg atgctcgcgt cgagattttt cttctttggt 2150041 tcaggctggc tgctgcgtat aatactgctt tgcgatgatg gcgcacgatg cgtcacactg 2150101 ctggcatttc cgctgacctg gcggatatgg ccgacaaggt tttccatatc aaacggtttg 2150161 agaataaagt aggacgcgcc taaatcgacg gcctttttcg tgacatcttc ctgcccaaag 2150221 gctgtcagca taatgacatt cggctgtttt ttcagatctg attccctcag cctctctaaa 2150281 accgcaagtc cgtctagatg cggcataata atatctaata cgagcacatc gggatctttt 2150341 tctttaaaca gcgacaggca ttcctgtccg ttataagcaa cgccgatcac ttccatgtct 2150401 tcctgtcctt ctatatattc acttaacagg cttaccagct ctcgattatc atcagcaaca 2150461 caaactttaa ttttctccac gtttcttcct ccccaaatgt agttaacagg attcaccctt 2150521 gctacatgtt tacattcgac aaaaccgcta tataccctct aaaaaaatca taatcaccaa 2150581 tattagtggc atatctttgt tattctatgt ttttctctgt ttttcgacta aaaatgaaat 2150641 ttgacaaaca aggaaacgtg aatttgtcga aaaatcttct tttgtatatt ttaccgtatg 2150701 tattctgaga agtgaagagg gatcaaaata aaaaaactgc cggaaactcc ggcagtcagc 2150761 ttgctttttc ttttccataa atatcgattc ctgcttctga cagcatccat tcaatatgaa 2150821 caccgtagcc gcttgtcggg tcatttacaa atacatgggt gacagcaccg atcacttttc 2150881 cattttgaat gatcgggctt ccgctcatcc cctgtacgat gcctcctgtt tctttcaaca 2150941 gtcttggatc ggtaattttc aacaccattc cttttgtcgc agggaatttt tgcggcgttg 2151001 tgctgacgat ttcaatatcg aatttttcta ctttgtcatc atcaataacc gttaaaattt 2151061 cagccggccc ttttttgact tcggtagaaa acgcaaccgg caatgcttga tctgatatgt 2151121 tgttttgaat cggctgatgc agtgtgccga aaatcccaaa cgggctgttt ctgttaatat 2151181 ccccgatcgt tttgcgttct gaggaaaatc gcgccagttt ttctcccgga ttaccgcctg 2151241 tccctttttc aattgatgtt acagtggatt taacgatttc tccattctcc actacaattg 2151301 gtttctttgt gtccatatcg gaaatcacgt ggccaagtgc tccgtatttt tttgttttcg 2151361 gttcataaaa ggtcatagtg ccgatgccag cagcagaatc tctgatatat aacccgattc 2151421 tgtatttgcc ttctccttca tccttttctg ggatcagctt cgttttgatt ttctgtttat 2151481 cacgtttgat cagtaagtct aaagattcac cagttttccc agccttttga ataaatgggg 2151541 ctacatcatt cattttttca attttctgtc cattcatctc aataatgatg tcgcccgctt 2151601 caattcctgc cgtttctccc ggagattttt tgccttcact tgtattgatt tgatgaaatc 2151661 cgacgacaag aacaccgacg gaatgaagtt ttacaccgat tgattgtccg ccaggtataa 2151721 cttttaaatc aggaagaaca tgcacttttg tttttttaat tggaaatccg gcaagatcat 2151781 ataccaattc tgactcacct gattttttgc ccgtcacctt gatttcatgc ggatctttct 2151841 ttactgtaaa cgcttctgag gattctgatg tctgagcgtt taccgataaa ctcgtttcaa 2151901 tcgcttgtgt ttgggtttca aatactctca tttgcgttgg aatcagtaaa tattctttta 2151961 gcggtttgca taaacctaca cttaataacg aaacaaggag aattaaacct actgcttttc 2152021 tgatgttatc gggcattcac tacttcactc tcctcgctcc tatcccacac cttctttatg 2152081 acttgctgct acatcattta attttgcctt ctgacggctt atttataact gtcatatgaa 2152141 gaaaaacatt ggatatactg atgaacgaat ggatgtgcac gaaaaaaata agctgcgctt 2152201 ctcgcgcagc ttacccagtt gttttgactt gatccgcttg ttttaaaagt tctttcgcat 2152261 ggcgtttcgt taagtcggtt acttcgacac ctgcaatcat gcgcccgatt tccgctacct 2152321 tttcctgctt agagagcggc ttgacacgtg tcgtcgttct gccgtctttt aactccttcg 2152381 caatataaag atgcgtatcg gccatggcag ccacctgagg caggtgtgta atgcacagca 2152441 cttgtgatcc tattgacacc ttatggatct tctcagcaat tgcctgtgcg accctgccgc 2152501 ttacaccggt atcaacctcg tcaaaaatga tcgatgtcac atcctgttgt gaggaaaaaa 2152561 tgctttttat ggcaagcatc acccgtgaca gctctccacc tgaagcgact ttcgaaaggg 2152621 atttcagcgg ctcgcctgta ttggttgaaa ttaaaaactt caccaggtca atcccttgtt 2152681 cagtcagctg aacgggctgg ccgtttacaa gcggcgcctc ttcattgcgt gacgctgttc 2152741 tgaccttaaa ttccgtatca aaagttgatt tttccatgta caggcttttt aattcccgat 2152801 gaatctcatc agccagcttt ttcgcccatg tttttcggat ttgtgacaca tttgccgctt 2152861 ccactgcgac atctttgccg acggagtcaa gctccttttt caagctttga aggtggctgt 2152921 ccctgttttc aatttggtca atctcttctt caattttaga agcatattcc aaaatgtctt 2152981 caacagtggc accgtatttt cgtttcagct gtttgatttc attaagtcgc gtctcaatat 2153041 agttcaggcg ttccggatca aattcaagct catccagcat atttctcatc tgaaatgtgg 2153101 catcctcaag caaatagtag gagttcgaaa cactttcaga catttttttc agcggttcgt 2153161 ttatatcaga tatatcttca agctgcgctg atgccattcc aacccagtcc aatccgccct 2153221 gctcactgcg aagcgcgtta tatgcatttt gcagcgactc atatatcttc tcaaagtttg 2153281 aaatttgctg gcgctcttct tggagctgtt catcttcgtt aagctcaagc tttgccgatt 2153341 cgatttcttc gagctgaaat tgaataagat caagacgatg ggccatttcc tgttcgcttt 2153401 cagaaagctg cttaagcttt ttgagcagct tcacataccg ctggtaccct tcctgatacg 2153461 ttttgagcgc gctttccact tcggccccgg caaacttgtc caaaagctgg agatgatttt 2153521 cgtcttccat taacagctgg ttatcgtgct gcccgtgaat atctaataaa agcctgccga 2153581 tctctcttag tgaagcaatc gtgacaagct tgccattgac acggcaaacg cttttcccgc 2153641 tcgtgctgat atcccttctc atgacgatca tttcgtctga aacgtcgatt ccctgctcag 2153701 cgcatacgcc taaaacagga tggccgctct ccaacagaaa cagcccttca agttcggctt 2153761 ttgcttcccc atatctaaca aattcagatg atccgcggcc tccgactaaa agagaaatgg 2153821 catctatgat gatggatttg ccggctccgg tttctcctgt taaaaccgta agcccgcgtt 2153881 caaaagaaac cgtcagttcc tcaataatgg caaagttttt aatcgatagt tcagctaaca 2153941 aacagcatta cacctcttat ctttgttaga ttttctgtta cagcagttca aggagcctgt 2154001 tttttacgcc ttctgtatct tcaggagtcc ggcaaataat taaaatcgta tcatctccgc 2154061 aaatggtccc catcatttca tcccagtcca aattgtccat cagcgccccg attgcctggg 2154121 cattgcccgg catcgttttc agcacaatca tatggcttgc tgagtctatt ttcacaaatg 2154181 cgtccatcaa tgcccgcttt agctttgaca gcggattgaa acgctggtcc gccggaagac 2154241 tgtatttgta agaaccatta tttgtaggca cttttacaag gtgaagttct ttaatatccc 2154301 gtgataccgt ggcctgcgtt actttgtatc catcctgctt tagcatgtcg accaattcat 2154361 cctgcgtttc gatttcattg cttgtaatga tctctctgat tttaatatgc ctctggcctt 2154421 tgttcatgta agcacctcta tttccaagct tatctgttct tttatgttat atgattctct 2154481 gcacattgta catgaatgca gaaaaaagga ataatagcgc cctattattc cggtacatct 2154541 gctttttttt cttttaacgt cttatgtgct tcttctacaa cgcgcatgat ctcttcttcc 2154601 ggcagttcct ggccttcctg tccctctccc ggccaatgca aatgaaggag aaactcaata 2154661 tttccgtctc ctcccgtgat tggagaaaat gacaagcctt tacagatata gccttcagcg 2154721 gcagaaaaac tgatcattcg cttgagcaca tcagcatgca ctttaggatc tctaacaatc 2154781 ccttttttgc cgacggattc ccgtcccgct tcaaactgag gcttaactaa agccatgcag 2154841 tcgctgcccg gtacgagcaa agtccttagg acaggcagga tgagccgcag tgaaataaag 2154901 gacacatcaa ttgtggcaaa ctccggcatg ccctttgtaa agtctgccgg tgttgcataa 2154961 cgaaagttcg tccgttccat cacgacgacc cgttcatcct gtctaagctt ccatgcaagc 2155021 tgattatagc ctacatccac agcgtatgac tgtttagctc cattttgcaa agcgcagtcc 2155081 gtaaaaccgc cggtggagga gccaatatca atcataattt tatctttgac agagacggga 2155141 aattccttca acgctttttc gagctttaag ccgcccctgc tcacatacct cagcgggttt 2155201 cctttgacag ttaacggaag gtcgcggtca attttttctc caggcttgtc caagcggttt 2155261 tcgtttgaat agacgatccc cgccataatg gctcttttgg ctttttcacg cgtttccgcc 2155321 agccctcttt ccactaataa tacatctaat cgttctttct ttgacgtcat gatccaattc 2155381 ctttgtgtgt ctttggtggc atcagtaatc taatacgatt tgccacctgc tgttttgtca 2155441 gtccaatttc ctcaagaagc gctgttacac ttccgtgttc aataaaccga tcaggtatac 2155501 ccattctgtc aatcggagta tgatattcac cttgatcatg agcgaattct aaaatcgagc 2155561 ttccgaaacc gccttctaag accgcttctt caattgttaa aattggcaag ccttctttta 2155621 ggatactctt catcatcttt tcatcaatcg gcttaataaa acgcgcattc acaacgcgca 2155681 cggaaaggcc ttctttctgc agctcttcgg ctgcttcaat cgccatttcg attgttgtgc 2155741 cgaatgttaa gatgacagca tcgttccctg gacgcagcac ctcccacgta ccgatcggaa 2155801 tcgttttcaa ctgttcatcc atttttacgc cgagtccgtt tccgcgcgga aaacgcattg 2155861 ctatcgggcc ttcgtcatag ctaagtgctg tatgaaccat gtgctggcct tcattttcgt 2155921 ctttcggcat cattaagacc atgtttggaa tgtggcgcat aaacgcaata tcaaacacgc 2155981 cttgatgtgt ctctccatca gcgccaacga gtccagcacg gtcaattcca ataaacacat 2156041 tagcgttttg gcggcagatg tcatgaacaa cttggtcata tgccctttgc aggaaggttg 2156101 agtaaatcgc caaaaacggc ttcataccct gcattgccat agctgcagcc attgttgcgg 2156161 catgctgttc tgcgattcct acgtcgaaca tccggtcagg gaattccttt gcgaagcctt 2156221 caagctttga accgacaggc atagccggcg taatggctac aatgcgtccg tcctcgcgcg 2156281 ccattcgctg cacagttccg ctgacaagac cgctccacga aggagctgcg gctttcggct 2156341 ttacaaagtc accggtatta attttatatg gtccggtacc atgccatgtc ccaatcgtat 2156401 cggtctcagc cggtttgtac cccttccctt ttttcgtaat gacgtgcaga agaacagggc 2156461 ctttcgtttt tttggcgtat tgaagattct caatcagctc atgataagaa tgtccgtcca 2156521 ctgggcccaa atacgtaaaa ccgagctcct cgaaaaacat tccggagacg agcatgtatt 2156581 tcaggctgtc tttgacccgt tccgccgtgg cggcaagctt gcccccaact gccggaatct 2156641 ttttaaataa gtattcaagc tcatctttga cccactggta tttccccgca gtgcggagcc 2156701 gtccgagcat agagtgaatg gcaccgacgt ttggcgcaat actcatttca ttatcattaa 2156761 ggatgacaat catgtctttt ttctcgtcgc cgatgtggtt aagggcttcg agcgccatac 2156821 cgccggtcag cgcgccgtca ccaatgatcg gaataatata ttcatccgtt cctttaatat 2156881 cacgggcagc tgccattccc atcgcgcctg acagagaagt cgagctgtgc ccggtttccc 2156941 aaacatcgtg ctcgctttca ctccgctttg gaaatccgca aagccctttg tactggcgaa 2157001 gcgtcgcaaa ttcttttccg cgtcctgtca gcagcttatg gacatacgac tgatggccta 2157061 catcccataa aaatttgtct ttcgggctgt taaattcctt atgcagggca acagtaagct 2157121 ctacgacacc taagtttggg ccgatgtggc cgccggaagc ggataaactt gtaattaaaa 2157181 actgacggat ttcatcactt aatttctcta attcatcaat ggacatgttt tttaaaaacg 2157241 acgggtcctg tattgataaa agatccaaag cggatcaact cactttcagc atgaatttct 2157301 gcaatgatac atgtcttttg catgccgagc tgacaataat ctcagacata aaaaaagaca 2157361 aacgcgcttt tccttttcat ttttcatata aactgcttac attttaccat acctcgtgca 2157421 gccgcttcaa attaggatcg ttttagtgat ctcttgccgc aattaaatca caaagctcat 2157481 ataaaaggtc tttttgaaga gagagtccgc cgatcaatcg cttcgcctct tttatatgaa 2157541 catccaattt atgtttggcc ccttccaatg aaagaagcga cgggtatgtc gatttgtcat 2157601 ttgtggtatc cgagccgaca cgtttgccga ttttctcttc actgccttct aaatctaaaa 2157661 tatcgtctct gatttgaaat ccgattccaa tgtggctgct gaaggtacgc agtgtttcaa 2157721 tgtcttcctc aggcgcatca gccaaaatag caccggcgat tacacaaaag ccaaggagct 2157781 tggcagtttt ccgttcatga atggattcga gctcttcaag cgtgacttgt cggttttccg 2157841 cttccatatc agctacttgc ccaccgacca tgccttcggt gcctgccgct gaaatcagtt 2157901 cattcacaag ccgcaggcgc ttttctgctg acacctcgtc tgacacgtgg gaggtaatca 2157961 gcttaaagct ttctgtgagc agcccgtcac ccgctaatac tgccgtcgct tcaccaaaca 2158021 ctttatggtt tgtcggcttc ccgcggcgca aatcgtcatc atccatgcat ggaagatcat 2158081 catgaattaa cgaatacgtg tgaatcattt cgacagcaca gcccaccgga atgccgtctt 2158141 tttcgctttt tccatatgca tttaaaacag ccagtacaat cagaggccgc aaccgctttc 2158201 cgccggcctg tagagaatat agcatagatt tctttaatga gtccggcata tcaagctttt 2158261 ctgtatagac agaaagctga ttttcaattg tttttttccg gtccgccaga aagctcgtta 2158321 atttatttgt caccttcgtc ttcctcctga acactgaaag gtgccagttc gccgtcttct 2158381 tttaaaatga agtccatttg cttttcgact ttttgcagct tttcatggca catttttgac 2158441 agagccatgc cttcttggaa atagttaatg gcttgctcta gaggcacatc tccctcttca 2158501 agctttgata caatgctctc aagccctttc atcgcttctt caaatgtcat gttttcattt 2158561 tttttcacgt ctgtcatttt tcttcccctc tcttttctaa tacttcacag gtcagcacgc 2158621 catccttcag cttgatttca agccggtcct gctcttctat ttgactgaca cttttaatga 2158681 gtttatcttc tttataagcc aagctgtatc ctctttccat cacttgaaga ggacttagtg 2158741 cattcagctt gccaagaacg gtttgaaatt gggaatgcag ctgcttcatt tggatattca 2158801 tattttttct cagctgattt gtttgttcct ggtatcgtgt tctcgcttgt ttcagctgtt 2158861 catgaggatg caatgcctct aatctgtacg tttcacgctc cagctgtctg cttttccgat 2158921 ctaaaagagc ggtcagctgt gcttgaaact gctggtacgc gaggtcaaac tgctgctctt 2158981 tttgcgcata caaacgcttt ggaaaacgaa aggcatagga cgattgcagc gtttgtatcc 2159041 gttctttttt ctggccgaga tgctgctgca ttgctcttgt cattctgact tccgctgttt 2159101 ttgtccgttc gattaaatca gtggtatgag gcacagcaat ctcagctgct cctgtcggcg 2159161 tcgcagctct gatatcggcg acaaaatcac taatcgtaaa atccgtctca tgtccgactg 2159221 ccgatataat cggaatattg gaagcaaaga tggcgcgtgc tacaatttct tcattgaatg 2159281 cccacagttc ttctatcgaa ccgccgcctc tcccgacaat taatacgtcg caaatctctt 2159341 tttcatttgc ctcttcaatg cgcgtaacga tggatctgct cgcattttca ccttgtacga 2159401 gcgctggaag aacaatgact tttacaaggg gatatcttct ttttagagtt gtaataacgt 2159461 ctctgacagc ggcacccgtt ggagatgtca caaccccgat tgtggctgga aatgcgggga 2159521 tttgtttttt gtagcggtcg tcaaataaac cttctccggc aagcttcttt tttaattctt 2159581 cgtacgctaa ataaagcgct ccaaccccgt caggctgcat ttctttggca tataattgat 2159641 agtttccgct cggttcatat acggaaattc cgcctctgac cagcactttc attccgtttt 2159701 caggtttaaa aggcagacgc tcgctttgtc tcgcgaacat caccgactgc attcttgcgt 2159761 tttcgtcttt taaagtgaaa taaatatgcc ctcgtgtgtg tatctttaca ttcgacaatt 2159821 cgcctttaat ccaaatattt tcaaggtgag gatctacatc gaattttcgt tttatatact 2159881 ttgtcagcgc tgagacggtc acatacgctg cttcacccat gtctaaaaac tcctctccta 2159941 agcattcctg caccataact aaagaaaacc cgccctggct ttaggagcct gaagaagcgg 2160001 gtatcgtgct catattcaag gcgggtaaac atttcgcctg tgaatatctc caattatcta 2160061 tgataacgta cgtttcgcag atttaacagt attatgcgca agcatcgtga tggtcatcgg 2160121 acctactccg cccggaaccg gcgttatgaa ggacgctttt tcctttgccc cttcaaattc 2160181 aacgtctccg caaagctttc cgttttccag acggttaacg ccgacgtcaa tgacaacagc 2160241 gccctctttg atctggtctg cactgatgaa gttggctctg ccgactgcca ccaccaggat 2160301 gtccgctttt ttcgtatgtt cagtaatatt ttctgttctt gaatgacagt aagtaaccgt 2160361 cgcgttttca tttaataaaa gctggccgac aggtttgccg acaatgttgc ttcggccgac 2160421 tacaacaacc tctttaccgg aaaggtcaat attggttttc ttcaaaagct caacaattcc 2160481 atgaggcgtg caaggaagaa acgtatcttc gccaagcagc attttcccta cgtttaacgg 2160541 atgaaaaccg tctacatctt tatcagggga gatacgttcg atcaccgctt tttcagaaat 2160601 atggtctggg agcggaagct gaacgagaat gccatgaaac tcagggtctt ggttatattg 2160661 atcaataatg gaaagcagtt cagcttctgt gaggctgctg tcaaattgat cgagcttgaa 2160721 attcattccc attgtttctg ccgctttttt ctttcctcgc acgtaagagt gagaagcagg 2160781 atcatctcca atcaaaataa ccgccagtcc gggagtgacg ccttgctttt taagctcttc 2160841 tacctctttt gccaattgtt cgcgtttttc tctagccgtt tcttttccgt cgatgattgt 2160901 tgcagtcatt ttctttcctc ctatgattgt tcaatatcag atttaatgtt agaaagaacc 2160961 ccgtttacaa actttgtcgc tttgtcatca ccaaaccgtt ttgccagctc aatcgcttcg 2161021 ttcatggaga cattcaccgg aatgtcttcg gcatatgcca tttcatatgc tgccaggcgc 2161081 aaaatcgcac ggtcaacatt ggcaatccga tcgagcttcc aattcaccag atgcttggag 2161141 atcatttcat ccagctggtc ttggtgttcc aataccccgt gtacaagctg ttcaaagaaa 2161201 ggatctgttt tttcttcatc cagtgcgtgt tctatggctt cattcactgc aatatcgctg 2161261 acatcaattt gaaatagtgc ctgcaaagct ttttctcttg ctgttcttct tttcattttc 2161321 tttctccttt gatcctcttt atccgcttgt cgttaagcca caaagagatc ataacatatt 2161381 tttttcgtat ccgcatattg aaatcaaggt ttttttaccc tattaccgaa tattttcaca 2161441 caccttaata tgattattcg gatttcacgt tcatgaagaa actcggctat gtaagccggc 2161501 tttcttcatg ctttgaaata aagggtaacg tgtaaaaaaa ccaaagggcc gccctcccct 2161561 tggtttcgtg ttaagccatt tacatttctt cgtcgatttg gacttcttgg gcttttgtgt 2161621 caaattgaat gccgacgatg tgaatattga tctcgttaat cgaaagagac gtcatattta 2161681 ataaggtttg acgaatgttt tcctgaacgg atgctgcaac tttcggaatc gaaacgccaa 2161741 atgtaacgac acagtataca tcgatcgtaa ttccgtcatc cgccaggtcg actttgacac 2161801 ctttgccatg attcactttg ccaaagcgct caacgacgcc tgtcgcaaag tttccgcgca 2161861 tttcggcaac tccatcaact tctgatgctg caatgccggc aatgacctca atgacctccg 2161921 gtgcaatctc aaccttaccc aaatgcgtat cttcgtgatc cattttaagc aagctgttgt 2161981 ctttcattca attcacctcc gtaaaaatta tgagcccatt acatcatatg tttctaaaaa 2162041 tttcgtatta aactctccgc tcacaaatgt ttcgtgttca agcagtttta aatggaaagg 2162101 gattgttgtc tcaatgcctt cgatgacgaa ttcgctcaat gcgcgcttca tgcgggcaat 2162161 cgcttcatct ctcgtttttc cgtatgtgat tacctttgca atcatgctgt catagtacgg 2162221 tgggatggaa tagccagggt acgcagctga atcgacacgg acaccaagac cgccaggagg 2162281 caggtacatt ttaatttcac caggtgacgg catgaaattt ttgcttgggt tttctgcgtt 2162341 gattcggcat tcgatggccc agccttcaaa ttcaacatct tcttgcttga ggctcagttc 2162401 cattcctgaa gccactttga tttgttcctt gatcaggtca gttcccgtca ccatttctgt 2162461 gactgggtgc tccacctgga ttctcgtgtt catttccatg aagtaatagc gctgttcatt 2162521 gtagtcatag ataaattcaa ctgttccagc acctgtatag ccaaccgctt tggcagcctt 2162581 taccgctgca tctcccattt gctccctgat ttctgaatca agggcaggag atggtgattc 2162641 ttccaaaagc ttttgcaggc gtctttggat cgagcagtcg cgttcgccca aatggatcgt 2162701 atttccgtag ttatcagcaa gcacttggat ctcaacgtgg cgaaaatctt ctatgtattt 2162761 ttcgatgtat acacctggat tcccaaatgc agttgccgct tcctgctgtg taatcttaat 2162821 gccattaatc agttcctctt cagtgcgggc aaccctaatt ccttttccgc ctccgcctgc 2162881 ggtggctttt ataattacag gatacccaat ttcattagca agcgaaaccg cttcttccac 2162941 attttctata attccctgtg aacccggtac gattggcacg ccggcctgtt tcatcgtttc 2163001 ccgcgcaacg tcttttgttc ccatttttga aatggcgtca gcgctcgggc cgacaaacgt 2163061 gacattcact tcttcacata attcagcgaa atcagcattt tcagctaaaa atccgtatcc 2163121 cggatgaatg gcgtccgtgc cagtcagctt tgcaacactc acaatatttg taacgtttaa 2163181 atagctgtct tttgatgctt tcggtccgat acaaaaagct tcatcggcca tttgaacatg 2163241 aagggcatct ttatcagctt ctgaataaac agcgacagtc tcaattccga gctctctgca 2163301 ggctctgatg attctgacag caatttctcc tctgttggcg atcaatagct ttttaatcat 2163361 gttcagtctc cttactccgc ttttacaaga aatagaggtt gtccgtattc gaccagctgg 2163421 ccgttttcta ctaatacttc aacgatttcg cctttcactt ctgcttcgat ttcgttgaaa 2163481 agcttcatcg cttctacaat gcagacaact gtgttttcat ttacttttga accggctgtt 2163541 acatacgggc cagcttccgg tgatgaagaa gcataaaatg ttcctaccat tggtgaagtg 2163601 attttatgca gattctcatc ttgctttggt gcttcttggg caggtgccgc tgcttgctgc 2163661 gcttgcggct gaactgcctg cggagcctgt gcttgtacag gtgctgccgg tgcctgctgc 2163721 atgacttgaa ccgtgcctgc ttcgtgtttt ttcagtttta aggatacacc ttcattttca 2163781 tatacgaatt cgtcaattgt agactcgtca attgctttaa tcagctcgtg gatttctttg 2163841 atatttaaca ttcaatcgca ctcctatgta tgaaatttct ttttttatag gttactacta 2163901 aaagtacata ctatgttcat cttacaggag cggacttttg aattcaactc taatatgaca 2163961 gcaacgcaaa aagcccgctt gtttagcggg cttttttccc tcattcttat ttagagggtt 2164021 caaatgtgac agcgacatct ttcattgttt tgatttcttt tgccacaagg tctataatgg 2164081 ctgtcgcctt cgatttagag tgtttgtctg atttgactgt aatattgatt ttatctcctt 2164141 cagcattaac aagcgcatcc tcgtaacctt gtgttttaat cagcgtttcc agctgttttt 2164201 ctgttccttc cacttcactg agagccgtca ttttatcgta tgcttcgctt ttctccttgg 2164261 ctgttgcatc atcgcttgac acaatggcat tcagctcttc tctttctttg cttctggcat 2164321 cttctaaatc aagacggtac gttgtaaaca aatcatcatc ggctgtttcc gtaacaacag 2164381 ttcctttttc actggcttca gcggatgttt ccttgtctgc tgatgaatct ttcgttccct 2164441 ttgttccatc ttcttttcct ttttcagttt ctgtaccgct tttttccttc gtgtcttgct 2164501 tggcaggcgc tttttcagtt gcgacctctc cgctgtcaga cgcgcttttt tcactttgca 2164561 tctgcacggc gtttttgctt tccggcgaca tgatatagta gacgcttaac accacgacaa 2164621 gactgagcat tgttaatagc caaacggttt gttttttaag catttatgaa tcctccttta 2164681 tttttttagg ggcaaccgca acccggtggc ttggaacatc caggacccgt gtcaccgctt 2164741 cgataatggt ttgttttatt tgaacgttgt ccactccttg agcaacaacg agtacaccgc 2164801 gtatatcagg ttttttcgtt tggacgacga caggtgtttc tttatcgccg tttttgatca 2164861 tgacgatttc ttcctccgat gattggtctg taacgcttct ttttccgcct tctttgtcag 2164921 tttcttcagt ggttgtattt ttgtttgatt tgtttttttc gtatactttc agcgacgttg 2164981 catctacatt cacgacaacc gagacatcgt ccacaccaat gattgtttca agaatttctt 2165041 tcagttgatt ttcgtattct ttttcatagt catcgatcga gtctttaggt ttatcagatt 2165101 ttgaggcttt aaacacttcg gctgttttct ctttgctgtc tgcggaatgt tgtgatgata 2165161 cggccgttat cgttttggcg ttttcagttt tctcaggtga agaaaacagc tggctgacaa 2165221 gcataaagga aactccgaga acaaaaacga atagaaagta atgatatttg gtcagcttcg 2165281 gcttttcgcc gtccttcgtt tgtcccggaa gaaactgctt tttcaataca ttccataatc 2165341 cgtttttatt cattgccgac actctccccg ccttccatat gaaccgtaat tttctcactt 2165401 ccgatttccc aaatgtccgc gagctgcgtt tgtatctgtt tggcttcttt ttgttcggct 2165461 gcttcttttg ttacgtatgc atgatctgta tcaatgtgga ccggcgcgac cgtttggacc 2165521 gttttttcag aagacggggc catatacacg ctgattgttt taatatcctc ttctgaatct 2165581 accttttctc ctgccgtgag tttgatgcgg cctactttat attcatcatg actgaatctc 2165641 tcctccgctt tcttttttag ttggacagcc atttcttcta gaatatatgc gcgctgggaa 2165701 gcttgtattt ctattttttt tgaattgatt tgatttttta tgtcggcaga ctctgactgc 2165761 ccgttttttg tgaggtattc aaagatgact tcggggtctg tcttgaaaag tttaaaaatc 2165821 ggcgtaagca tgacgacaat caagagcagg ctgactacca tttttgcgta cttttgcatg 2165881 ctggagctcg gcagcagcat atcaatcaca attgcaaata ggataaacaa cacgatggtg 2165941 gtaagccatt ccgttaaaaa actcatttgc ctgcctcctt catttcatca tcatcgtgag 2166001 gtttccggct gtgattatga cagtaaggct taaaaaaaac atgagagaca caatggcgag 2166061 agctgcaaaa atataaatga cgcttttgct gatgacgtcg aggcaggtga tgacgggccc 2166121 gcctcctagc ggctgaagaa tcgcggctgc cagcttataa ataaaagcga gggaaagcac 2166181 tttgattgcc ggaaatgccg caatacagat caaaatagcg acaccgagaa tccctaccgt 2166241 atttttcagc agtaaagagg cgctgattac tgtatctgtt gcgtctgtaa acattcggcc 2166301 aagcacagga ataaaatttc cggttataaa tttagccgtc ctgagcgtaa tgccgtctgt 2166361 cactgcagct gacgctccct gaacagagat gacgccgaga aagatggtaa gaaaaacagc 2166421 cagtgctccg atggcgatat ttctgagcag gttagccagc tgcgttactt tgtattgttc 2166481 agtcatcgtg ctgacaatgc tcagaatcgc tgataaaaaa atcagcggca tgacgatatt 2166541 ctgaatcaag agaccgctcg tgttcatcag gaagaggata acaggatgaa agaaggcagc 2166601 agatacagct ccgcctgagg aagccaaaag cgccaagagg agcggaatga gcgccaggat 2166661 aaagctggtc atcgtctgaa tcgcctcagt tgcatagtta attgccacat gaaagctatt 2166721 aagcgcaagg ataatcagca ccatgtacac aattgagtaa gcgaccttac tgacggtgct 2166781 ttgctgaaaa gcattttgca aaagctgcag aatgacgcaa aaaatcgtga gcaaaatcaa 2166841 tgtgcccagc agctttccgt tggcaagcac ttcatgaaac aaataagaaa agagagcttt 2166901 cagccattct tgcggtgaga atgatttatc gccattgata aactccatta agctgccttt 2166961 ttggctttcc ggcagcagtc cgccgtattc tgtcataatg tcattccaaa attccccgat 2167021 cttatctgtt tcaagcgagg ctgctgtcct ttccgctaat tgctcggctg tttcagcatg 2167081 gtcttccgtt tgttctgcat taccagctgc ttgtacaatt tctgcacggc ctgctatgat 2167141 cagcacggcc aaaagcaaaa cccattgaaa gcgcttcaat ctaccgcctc ctttcggtta 2167201 tgacatagaa ggtataagtc cgagaatcgt ttcgataatg acggttaaaa taggcacagc 2167261 cattacgagt attaaaattt tccccgccaa ttctattttc gaggcgatgg ctccttgacc 2167321 ggcatctttt gtgagctgtg ccccgaattc agcaatatag gcgattccga taatctttaa 2167381 aatggtttca acatagacca tgttgacatt tgcattaatc gcaatttttt ctatcattcg 2167441 aataatgtcg tagatttggt ctaccaaata aagaaaaatg gcacatccgg caaaaacgac 2167501 gattaaaaac gcaaaagtcg gcttttgttc ttttacaatt aaagaaagga aggtggcgat 2167561 cagccctaaa cctacaattt gaacaatgtc aatctgcaag cccccctatc cttggaataa 2167621 aaacacagct tttatctttt taaataggtc atctacaatc gtggcgacca taaataaaat 2167681 atagataaaa cctaacagcg tcacccactg agcatattct ttcttgccca tctgatccaa 2167741 tatcgtgtgt aaaaaagcga ccacgattcc cactccggcg atttgaaata tgacattcac 2167801 gtctactccc attttatttt tgctcccctc acgtttacat caatagaaga atgagtaaca 2167861 agcccgctaa aaagcccaaa ctttttatca tcttttcgtt tttcgcttgc gcctgctcag 2167921 catccgcttc tgaggcttcc aaatgtgtca gcgccagctt gatgtgcttt tgctgagaga 2167981 ttcgatcatg aatcccaagc gtctcgccaa actgcttcag cacttcgtat tcgctttttt 2168041 tcaaagacag ggtgtcccat accttcttta agctttgctc ccacgccgtt ttcgcggaat 2168101 cacttccctt gtccagctga tcactgaatg cggaaaaaag agttgaaaca ggctgtgcga 2168161 gctgtttggc aatctgctgt gaagcagtat gaagcggtgt atggccgtac atgatttcag 2168221 cctcgaggga ttgaagcgcc gcacgcagct ggcggatttg ccgcggccgt tctgtataaa 2168281 tcttcgccat ctcaaaacct gtccatgttg tcgctaccac aatgaataca gcgcccagca 2168341 gcttcagcat gttttcacgc ccgtcgtcct agacagcaca tttccgtctt tgtcataaat 2168401 ttggctcact gtgcccggcc cttttgctct tgataattcc aaatagcggt caaaggctct 2168461 ttcttcccac aaacgcttca atgaaggccg cttcatcagg tcggatatac tccagccatg 2168521 cgccgatacg attactgaaa caccggcatg cagcgcctcc agaagtgcat ctgtatcttc 2168581 catacgcccg atttcatcga caatcatcac ctcagggctc atggatcgaa tcatcatcat 2168641 cagcccttca gcttttggac aggcgtctaa cacgtcaatt ctctgaccaa attgatgctg 2168701 cggaataccg cgaagacatc cggcaatctc tgaccgttca tcgacgatcc ctgtctttac 2168761 gggcagcatg ttttttttgc cggtgcttga gagcctcgca aggtcccgga gaagtgttgt 2168821 tttgccggtt tggggcggtc cgataatcag cgtattcagc cagctgtttt gatataagta 2168881 tggaagcagc ggctccgcaa tccccagctt ttgccgggca attcgtatat taaaagatgc 2168941 gatgtcacgg aggcctttca cacctccgtt ttccgtaatg actctgcccg ccagtccgac 2169001 tctgtggccg cctctgatcg tgacataccc tttcttcagc tcttcttcaa gtgtatacat 2169061 actatagttg ctgagccggc tcaggatcag atgggcatcc tcggccgtgc ccgcatagga 2169121 caaataaaca ggttgtcctc ttcgaatcaa ttcaacaggg cggttgatcc gaattctgac 2169181 ttcttcgatt tccagccatt gttgttccgg tatttcagaa agggcgtttt tcatggattc 2169241 agggagaacc tcagcgattt cattcaacag agcctcctcc tttctaccga ttggcttctt 2169301 taaaatgtat gatgtgaggc agactttatg acaagcctct ctttatttat gaacacccgc 2169361 caaaatcaag acaacacccg taaaaatcag aatcagcttt gcatacgaaa gctgcccggc 2169421 aatttggtag attccgacag tcattgtaat gataaaaatc aacggaccga caatagcgag 2169481 aatgctgtta accacaaccg ccttccggac atcgttggtc acaagcatga caattgctgc 2169541 cgtcagctca atcatagagg ataaaactcg taatcccgcc attgttaaaa cagtagaatt 2169601 gatatttcca agtaaaaatt tcatagcact ctcccaacct cccatttttt tatatgatat 2169661 gctctagctt gctgaagtag tcttgtcatt ttcgtataaa agaaagattc tgtttttggg 2169721 cacaaaaaaa gcctgctccc atttgggaac agacttcttt ttttctttct atgctcttga 2169781 aacgtaagaa ccgtctgatg tattgacaac aagtgtgtcg ccttcattca caaagaacgg 2169841 cacgtttaca acaagcccgg tttcagtttt cgcaggtttt gtaccgcctg acgctgtatc 2169901 acctttaata ccaggttcag tttcaacaac tttcagctca actgtgtttg gaagttcgat 2169961 accaagtgtt tcatcctggt acatcatgat atgcacagac atgttttcta gcaggtattt 2170021 taattcttct tcgatttgag ttgcgctcag ttcaagctgc tcataagaag aagtatccat 2170081 aaatacgtgc tgatctccgt ttgcatatag atattgcatt gttttggttt cgatttgcgc 2170141 tttcgctact ttttcaccag cgcggaatgt tttttcctga atcgcgccag tgcgaaggtt 2170201 gcggagttta gagcggacaa atgccgcacc ttttccaggt tttacgtgct ggaagtcaac 2170261 gacgcgccaa atgccgccat ctacttcaat tgttaatcct gtacggaaat cgttaactga 2170321 aatcatgttt aatgtcctcc tatattccaa tcacaaaata ataagttctt ttggggaatg 2170381 ggtgattgtc cggttgccgt tttctgtaat cacgatgtca tcttcaatgc ggacaccgcc 2170441 tgtttctggt atgtaaatgc ccggctccac tgtgaccacc atacccggtt caaggatagc 2170501 tgaagatctg acggataatc ccggcgattc atgaacttcc atgccgagcc cgtgcccggt 2170561 tgaatggccg aaatagtcac cgtagccttt tgcagcaata tgatcccttg tgagggcgtc 2170621 agcctctttt cctgtcattc ccggcttaat atgtgcgacg ccaagcgcct gagcatcaaa 2170681 tacaacctga tagatctcct tcaattgatc actgggctga cctacagcga ccgtccgggt 2170741 aatatcagaa caatatcctt tataataagc gccaaaatca agcgtaacaa ggtctccgct 2170801 ttcaatcagt ttgtcactgg ccacaccgtg cggaaggctt gaacgaaggc ctgaggcgac 2170861 aatcatatca aaagaagagc tgtctgctcc ctggcttctc atataaaact ccagctcatt 2170921 ggcaacagcg atttcagaaa tgccgggttt cataaacgtc aagatatgtc tgaaggcatc 2170981 atctgcaatc ttcgcagctt cctctaatat cttaatctct tcactagact taatcaagcg 2171041 caacttttcc acggattcag ccacaggcac taattcggca tcactgataa cggcgctgta 2171101 tgaagcgtaa gtgccatatg tcatgctgtt ctgttcaaag ccgagacgct tgatgccaaa 2171161 cgattcaaca gtgtcggcag tggtctgaat caagctgccg ccatgttcaa tgatctcaaa 2171221 accctttacc tgaaccttcg cctgctcagt ataacgaaaa tccgtaataa acgctgcttt 2171281 gtcacccgat ataacagcca aacccgccga acctgtaaac cctgtcatat agcgtacatt 2171341 agtgttgctt gtaatcagca tgccgtcaat tcccagctgt ccaaacaggt ttcttaattt 2171401 ctctagcttc atcttgattc tcccccttgc tggcttaata agtagcgaac agcaagcttg 2171461 tagccttcag ctccaagacc gacaatctgc cctttcgcaa caggagcgat aaccgactga 2171521 tgcctgaatt cttccctggc gtataagttt gataaatgca cctctaccac aggaagactg 2171581 atgcttgaaa cagcatccct gatcgcatag ctgtaatgac tcagggcgcc ggggttcaga 2171641 acaatcccgc tgtattgctc ctcagcctca tgtatcgcat ctatcaaatc accttcgtga 2171701 ttagactgga agaaagtgag ctggatatgt aaggcttcag caaactgaaa aagatctgtt 2171761 tcaatatcgg tcagtgtctg gcggccgaat acttcaggct cacgactccc aagccggtta 2171821 acattcggtc cgttcaaaat caaaaaatga ggcacacaat ctctcctttt cgcgagggtt 2171881 tctcatgtaa aaaatgttca cttctcgtga acattttatc atactggaaa aggattatac 2171941 actattctct atgcattccc agcgcacgtg caagcttttc cgaattcagc tcattgtatt 2172001 caaatgaaat agaatacccg acaaacagcc cgtaaagcaa ataaatgcaa atggtcgtaa 2172061 taattgtatc tgatgtcagt tcggtcaccg tgcgcacatc tggaaaaatc ggattaaaaa 2172121 caaaaaacac gagcagccaa agcaccaagc cgtataaaat acccggccac attgttttta 2172181 aacgtttcaa tagaagaaaa taaagaaatg ctgcgccaat tgaaattact ccaatcaaaa 2172241 tgatgctgat taccgttccc agcccatgtt ttttccactc tccgagtaca aacggctgca 2172301 atatcatatt cgggctgatt tcggaaaaat gaaacaaata tgcgatataa gcaacgaaac 2172361 tccaaagtac gcctccgcaa aaacctgttg ccgccaccct gccggccatt gaaacaggcg 2172421 gcttttgctt ctcattcaat tcttcatttt gttctgtatc tttttcgctt gtcatcatgg 2172481 cacctccagt taaagtgtgc ccaaaaaatg aaatgtcaat aaaaaagctc acactttttg 2172541 gcagctgcga gtaaaatttg aaaataacgg gtataatgca tgtagaaaaa gcaaggctat 2172601 ggcaattttt tcagcctgtc aatctagagg tttagcgctg tttcctgtac aatagagtga 2172661 aaggaaatgg ttagcaatcc taaagaaata ggcaggttga taatatgtca aaacataaag 2172721 ttccgcccgc ttacggcggg caggctgttg tggaaggcgt tatgtttggc ggaaagcatc 2172781 attacgttac agccatcaga agaacggatg gaagcattga cttttttaag cttccacgca 2172841 aacacaaccc gaaactgaac atcgtgaaaa agataccgtt tttacggggg atcgcggcca 2172901 ttatcgaagc gagtgcaaac ggcacaaagc atttgaattt ttcaagcgaa cgttacgggc 2172961 tcgatccatc tgaagacgag acacttgagc aggaagaaaa aaaatcctct gggctgtcta 2173021 tgtatctcag cctcgcagtt ataggcgtcc tatcattttt gttcagtaaa ttcgtattta 2173081 cattggttcc agttttctta gcggaactga caaggccgat tttttccttg aacacagcgc 2173141 aaatcgcgat tgaaagcctg tttaagttga ttttgctgct cggttacatc tattttttgt 2173201 ccatgacacc gcttattaaa agagtgtttc aatatcatgg agccgaacat aaagtcataa 2173261 actgttatga acagaatttg ccaattactg tggagaatgt ccaaaaccaa tctcggcttc 2173321 attaccgctg cggatcaagc tttattttat ttacgattat tgtcggcatg tttgtttatt 2173381 tactcgttcc gacagatccg ctttggctgc gtgttataga tcgtgtcgca ctgataccgg 2173441 tcgtgcttgg tatatccttt gaagttctgc agctgacaaa caaagtgcgt gacattcccg 2173501 gtctgaaatt acttgggtac ccgggacttt ggcttcagct gttaaccaca aaggaaccta 2173561 aggatgaaca ggttgaagtt gccatcgaaa gctttaacga acttctcaga ctcgaagcat 2173621 tgtctgagca aaatcagaag ccttctcaca acgtcatcta aaatccgttg ccctgctatt 2173681 actttcggag gtggacagtt atgaatcatc gtgtacaacc tattattgct gtattaattg 2173741 cgctgggagc gttcggtttc ctctatgtgc tggtaaccaa tcccggagaa atggcaaaaa 2173801 tggcggtaac cgtcatcgtg gcaggtatca ttatttattt tattgtgaaa tatgtaatga 2173861 atcgaaatgc gggcagcgaa ggagcagcct tcaaaaaagc ggcgaaacaa tcacggcgcc 2173921 ggatgaaaga acaaaaagca aaacaccgcg ccggacataa gggacgtgtc agccacctgc 2173981 gaagcgttcc gagcgccagc aagcctaagc cgatgattct caagaaaaaa agccagactc 2174041 agctgactgt tatagaaggg aaaaaaaata aaaagaaaaa cagagcgctt ttttaatagg 2174101 tccactgctt taaaaacagc tctgtccgtc ttttacctag ctcaatcagg gctagttttt 2174161 tttgttgtgt taaatgaaaa tcagtggcca ttacgtcatc aacagggaga aaaatgatat 2174221 tttgttcata gcgtgacgca atgtgccttg cgtcatgagc atccttcatc gtttcaaaca 2174281 gggcgccgaa cagttcaaaa gcgttgcgga tatttttttt cggacgctct ctttcacgcg 2174341 gcgcaagcgt gacaccgatc acagggcgct ttctttcctt tgaaaacagc cagattggaa 2174401 aattgcttaa cacgcctccg tcgacaaccg tggcggtgcc tgtgtccgtt tttaatttta 2174461 tcggttcaaa gaaatacgga atgctgcagc tcattctgac cgctctggca accgggaaca 2174521 tatctggatt taacccgtaa cgggccaaat cgtccggcaa aacaatcatg gtgccgtttg 2174581 tcagatcaga agcaataagg cgcagagacc ctttctgcaa atcgccgaaa acccttatgc 2174641 ctttcgctct taacagatca gcaatccatt tttctatcgt atcgcctttg tataagccaa 2174701 gacgccagta gatggacacc cactggagca tctttaaggg gagaaatgag tacctctgat 2174761 ccagcaattt ctctccgtcc acttcttcaa ttaaagcgtg gatttcctta ctggtgtaac 2174821 ctgacgcaat gaaagcggca ataatggcgc cggcgcttgt acccgcaact cttttaaagc 2174881 ggaagccttt ttcctcaagc acttcataag cgcctgcgag cgcaatgcct tttactcctc 2174941 cgccggaaaa cacaccgtca atatacatct cattccctcc ccctccatcc gatcgtttat 2175001 taccatttta agaaaacacg cgaagaaata gaccaacgaa tgacgggtgg cgtcagcgta 2175061 tcaaaaaaga cggcctcctt cgagaccgcc tttttactga ttatgatgtt ctgttttctt 2175121 ttggattgat ttcagatctt ttttacgggc atcatcttct tcaaaatatt gaacaagatc 2175181 cccgatgcga tcaatactgt tccagcttaa atgatgttcg attccttcga catcgttata 2175241 tattttctct tcatcaacac caatgattct taaaaactgc tcaagcaatt catgtctgta 2175301 taccagccgt ttgcctattt ttttcccttt agacgttaac acgagaccgc gatatttttc 2175361 ataaattaaa tattcgtctt tatctagttt ttgaaccatt tttgttacag aggagggatg 2175421 gactgccaat gcttccgcga tatcggaaac tcgtgcatat cctttttctt caatcagcat 2175481 ataaatctgt tcaatataat cttccatact tggtgttgtc atcgaaaccc tcccaaaaag 2175541 caccttaact ttataaacca ttacaagttt acactaatga acttgaaaaa acaaggatgc 2175601 tccgcgggtc aaaagccctg tttaccgctt ataattccat tcatctgaag cgtactttgt 2175661 ttcagccaag tgatgaacaa aatcaagctc ttcctgagaa agttcatatg gctccaaatg 2175721 aatgttaaga cctgtttcaa atccttcttt aaaggcttta cgagcctcat ccatcgtcac 2175781 ccgcttttcg atgagttcat taatggcaac cgctttattt ttgaaattgc gctgcatccg 2175841 ctctcttact ctttcacttg gatataagaa cagatcgaac agcttgtcct catctaaatc 2175901 aagaagaatg gagccatgct gaagaatcac acctttttgt ctcgtttgcg cgcttcccgc 2175961 caccttgcgc ccctcaacca ctagttcata ccacgaaggc gcgtcaaaac aaacagatga 2176021 ccgcggattt tttaagcttt ctttttcttt ttcagttctc gggatggcaa agtaagcgtc 2176081 cagaccgaga tttctaaagc cttgaagtat gccttctgaa ataacccggt aagcctcagt 2176141 aacagtcgcc ggcatctcgg ggtgctcttc cgaaacaatt acgctgtatg tcagttcctg 2176201 atcgtgcagc acacctctcc cgccggtcgg gcgtctgacg aatccgagat tatatttatg 2176261 tactgcttca aaattgattt cctttttaat attttgaaaa taccctacag aaagtgtcgc 2176321 cggattccag ccgtaaaaac ggataaccgg ggggattttc ttttcgctgt gccaatataa 2176381 aagcgcttca tcaagcgcca tattgaatgc aggacttgca ttgcctgagt ctataaaccg 2176441 ccaagtttct ttttgcattt taagaccttc cttaccgttt taatagaatc agtttatcaa 2176501 actgtcggga aaatgaaaaa tattttagtt ccattataga tgacaatcac gctgtgcttt 2176561 actataatag tatttgtcga aaacggctct atgaccttgt tttatgaagc agggttttga 2176621 ttttatatgc taaaggagta gaatcacatt gtctaatatg atcgttttga ttatttttgc 2176681 tgcatttatc atctatatga ttgcttcata tgtctatcag cagcgaatta tgaaaacact 2176741 taccgaagaa gaattccgcg cgggttaccg caaagcgcag cttattgatg ttcgtgagcc 2176801 aaatgagttt gagggcggac atattttagg cgcccgcaac atcccgcttt cccagctgaa 2176861 acagagaaaa aatgagatcc gtacggacaa gcctgtttac ctgtactgcc aaaacagtgt 2176921 ccgcagcgga cgcgcggcac aaaccctgcg caaaaacggc tgcactgaga tttacaacct 2176981 aaaaggcggc tttaaaaaat ggggcggaaa gattaaagcg aagaaataaa gcaaacagct 2177041 gtctggtaga cagctgtttt tatttatctt tcttccgcct cgtatctgag cactgggtgt 2177101 ctcgccgctt ttgtttcatc cattcttttt acaatcgttg tatgcggggc ctcctgaaca 2177161 agctccggat tctcctccgc ttcttttgcg atttgaatca tagcatcaat aaacgcgtcc 2177221 agtgtttcct ttgattcggt ctctgtcggc tcgatcatga tgcattcttc aacattaagc 2177281 gggaaataaa tcgtcggcgg atgatagccg aaatcaagga gccgttttgc aatatcaagc 2177341 gtacgcactc ccagcttttt ctgccgcttc cctgataata caaattcatg cttgcaatgg 2177401 cggtcaaacg gaagatcgta ataaggcgcg agttttctca tcatataatt ggcgtttaac 2177461 actgcgttct cagtaacagc ctttaatccg tcaggcccca tggagcgaat atacgtatac 2177521 gctctcacat taatgccaaa gttgccgtaa tacggcttca cacggccgat cgcatgaggg 2177581 cggtcataat caaacgtaaa gcgcccttct tttttgacta aaactggctt tggcaaataa 2177641 ggaatcagat cttgttttac gccgacaggg cctgagccgg ggcctccgcc gccatgaggg 2177701 cctgtgaatg ttttatgcag gttgaggtgc accacgtcaa atcccatatc accaggtctc 2177761 gccttgctta aaacggcatt taaattagcg ccgtcataat acagtttccc ccccgcttgg 2177821 tgtacaattt ccgccatctc tgtaatctgc tcctcaaaca agccgagcgt gttcggattc 2177881 gtcagcataa gagctgcagt ttcttcattc actgctcttt ttaaatcctc taaatcaaca 2177941 agcccttttt cattcgattt caccgtaacg gtttcaaagc ctgctactgt tgctgatgca 2178001 ggattcgtcc catgcgcgga atcagggaca atgaccttcg tccgcttgaa atccccgcga 2178061 gcttcatgat aggcacggat catcatcagc cccgtccatt cgccgtgcgc tccggcagca 2178121 ggctgaagcg taacctcatc cattcccgtt atttcttcaa ggtgtttgct taaatcatat 2178181 aaaagctcta atgcgccttg caccgtgtct tcatcctgaa gaggatgaat cgcagcaaaa 2178241 ccaggaatac gtgcgatttt ttcattgatt ttcggattat atttcatcgt gcaagaaccg 2178301 agaggataaa aaccggaatc caccccgtga ttgcgtttgg acagcgctgt ataatggcgc 2178361 atgatgtcca gctctgaaac ctccggcagc gctgcgtctt cgtcacgaat ataggtgtct 2178421 gacaagaggt cccccaattc gatttccggt acatcgagct ccggcagact atagccgatt 2178481 cggccttctc ttgaaagttc aaaaataagt gcctggtcct gattactcat ggcgatcccc 2178541 caattcctga atgagtgcgt caatttcttc ttttgttctc agctctgtta cagcaatcag 2178601 catatggcag tccagctctg gatacgtcaa cccaagatca tatccgccaa tcatgccttt 2178661 tgccagcaaa cgcttgttca cagctctcac cggctcatcc agtttgatga caaattcatt 2178721 aaacatcggc ccgtcaaaca taacagtaag gcctgctttt tttgcttctt gctttgcata 2178781 gttggctttt aagagatttt ggcgggctat atcttttacg ccgttttttc cgagagcagt 2178841 catggccact gatgctgcca gcgcatttaa agcttggttc gagcatatat ttgatgttgc 2178901 tttatcccgg cggatatgct gctccctggc ttgcagggta agcacaaagc ctctttttcc 2178961 gttttcgtct tccgtttgtc cgacgagacg gcccggcacc tttctcatta attttttagt 2179021 aacggcaaaa aagccgcaat gcgggccgcc gtatgctgaa ggaatgccga aaggctgcgc 2179081 atcaccgacg acgatatcag actgaaactt gcccggcgga gtgagaagac ctagcgccag 2179141 cgggttggct gaaacaataa acatggattt cccttgatga gcgataggct caatatcctt 2179201 tagcggctcg atcctgccga aaaaattcgg gtactgaacg atcactgcgg ctgtgttctc 2179261 gcaaacggtt tggcgcaatg catcaagatc cgtaacgcca tccgcagcgg gtacttcaac 2179321 aacatcaata tactgacctt ttgcgtaagt tttcagcacc tctcgcgatt caggatgcac 2179381 ggtttttgac acaacaattt ttttcttttt cgtgtggcct gaagcaagca ttgctgcttc 2179441 tgccaaggct gttccgccgt catacatcga ggagttggcg atatccatgc ctgtcagttc 2179501 acagatcatc gtttggaatt caaaaatagc ctggagctct ccttgtgaaa tctctggctg 2179561 ataaggcgta tatgcggtat aaaactcaga gcgcgaaatg acatgatcca caatgacagg 2179621 ctgatagtgg tcatatacac ccgctcctaa gaaagaagcg tattgtacgg tatcacgatt 2179681 tttagaggcc agctttgtca gttctcttgt taattctgtc tctgatttcg cttttttgat 2179741 ttgatgctct tttttatatt tgacgttttc cggtatatca gcaaataaat catcgatgct 2179801 gcttacgccg atagtagcaa gcatctcctg tttatccttt tctgttgcgg gcaaataacg 2179861 gtgcttcatg tgttgtctcc tctctccaag aaaaaatatt agcgtttata aaatggtgtt 2179921 ttgacaacct ttgctttcac taattttttg cgtatctcta catctacaac agtcccgatc 2179981 tcactcgttt ccgaatcaat taaggcaagg ccgacgtttt ttcctaatgt cggtgactgc 2180041 gtgccggttg tcacctttcc gacagacttg ccattttgga aaacctcata tccgtgccgc 2180101 ggtatccctt tttcaatcat ttcgagaccg acaagtttgc gcttcgctcc gttttctttt 2180161 tgttcactca atactgactt accgaaaaag tcagactcct ttttgtgctt tacagcaaag 2180221 cctatacctg cttcaatcgg tgtaatatcc cgggtcagct cctgaccgta gagcgggagc 2180281 ttcgcttcaa accggagtgt atcacgtgca ccgagaccgc atggaatcaa tccgtatgca 2180341 tcccctgcat cgatgatttt tttccaaata tgcatagcat catcactgcg gcagtaaatt 2180401 tcatacccgt cttctcccgt atagccagtg cgtgaaataa gtgctttgcg gccgctgata 2180461 tcggcttcat caataaacgc aaacggcttt aatgcagaca catccgcatc tgtcagattt 2180521 tttaagatcg cttctgcttt cggtccctgt acagccaaga gcgcgatttg atctgactga 2180581 ttgtcaatct gcacatcacc tgctgcatgt tctttcatcc aagccaagtc tttatctata 2180641 ttagaagcat taatgacaag cagatagcgg ttctctcctt tttgatagat aagcaaatca 2180701 tcgacggttc cgccatccgg gtaacacatc gctgtatatt gagcacggcc tggcgttaac 2180761 gcggaaacat catttgtcat caatctttgc aaaaaagaca gactgtcgtt ccctgacact 2180821 tcgacttctc ccatatgaga tacatcaaac aaaccggctg cagttcggac agcctcgtgt 2180881 tcttttttta tagaagaaaa ttgaacagga agctcccagc ctccgaaatc aatcgttttt 2180941 cctccatatt ccttatacag gtcaaataac ggcgttcttt tcagcatcta attcctcccc 2181001 tttatcaacg gcgcagctaa aaaacataca aaaaaggaca gagaaacacc tcatgtaaaa 2181061 tgaaggttct ctgtcctggc acctgaaagt ttactttgca tacgcaaaga cgtccccttt 2181121 ggtggtttgc gcatccgcac aaacactctc cagagttgcg tcgagcaaga gttcttttgc 2181181 ctgagagatt cactccgcag tttgctcctt cggcgcctgt atcccgaggt tttcggtcag 2181241 gtctctcccc ttgctgtcat tcgctcatat tttcatgctg ttatggacat actatagcaa 2181301 tatcttacat caaatacata ctcatatcct accatcatca ctatatgctg ggcaacagca 2181361 atttgggcag atttttctta tattattcat cttaagaatc gaagaataag aaaggcggtt 2181421 tcaaagcaat gaatacagaa atgatctacg atgcaaaatg gcctgaagaa tttgctgaaa 2181481 gactgaaaaa cgatggccct tgggcaaact gggaactgta caagctctct gcagaaatcc 2181541 agaaaacatt agcaattcca gagtttgaag gcttacgggc tcctttatat ctgccttcct 2181601 ttacgccgct cccccaccag cttgaagtgg cgcaaaaagt ggttgaaaaa atgaacggga 2181661 aagcgatttt agcagatgag gttggtctcg gaaaaacggt tgaagctgga ctgattctaa 2181721 aagaatatat gattcgcggg ttagcaaaaa aaattttgat ccttgtgccc gcttcccttg 2181781 tgtcacagtg ggtcaaagag cttcaggaaa aatttttgat tccggctgtt gaacaaaaga 2181841 aaagctatgt gtgggagcaa tgcgatattg tcgtctcatc aatagacacc gcgaagcgct 2181901 cgccccatcg agaaatcgtt ctgtctatcc catatgatct tgtcattatt gatgaggcac 2181961 acaaactgaa aaatagcaaa acgaagaact atgaatttgt ccggaatctc gtaaaaaaat 2182021 attgcctgct tcttaccgcg acgccaatcc agaaccgtat cgaagagatt ttcaatttgg 2182081 tgtccttatt aaaacccggc catttaggca gtcagaatca ctttcaggag gagttcgcca 2182141 agaagaaatc cagtttagaa gcgcatgaac atttaaaaga tcttgtgaat aaagtcatga 2182201 tccgtaacag gcggcatgat acagggctga attggaaaca gcgccatgtt gaaacagtgc 2182261 cgattcaatt ttctccatca gagcaggcgc tttatgatga aatttctcgt ttgaaggaca 2182321 gtatcaataa accagccagc atgttctcga ttatgacctt gcaaagagaa tgctgttcga 2182381 gcagagaagc ggtatatatg acgctgaaaa agatgcttga tcaaaaagag aaacaagcac 2182441 ctgccattga tgaggatacg atttcagttt tgatagatcg catcaatcaa gtgacacaaa 2182501 actctaaagc gcttcaagtt gttgacttga tcaaaaagat cgacgataag gtcatcattt 2182561 ttacagaata ccgcgcaacc cagatttatc tgcagtggtt tcttcagcaa aacggcatca 2182621 gttctgtgcc gtttagaggc ggatttaaac gtggaaaaaa agactggatg aaggatcttt 2182681 tccgcggaaa aatccaagtc cttattgcaa ctgaagcagg cggtgaggga attaacctgc 2182741 aattttgcaa tcacatgatc aactatgacc tgccatggaa cccgatgcgg cttgagcaaa 2182801 gaatcggaag aattcacaga ctcgggcagg agcgtgacgt gcatatttat aacatggcga 2182861 caaaacatac ggtggaagag catattctaa agcttttata tgaaaaaatt catttgtttg 2182921 aaaaagtggt cggtgaactt gatgatattt taacgaaaat tcaagtgaac aattttgaag 2182981 agcaccttca tgacattttg tatcactcag caacagaaga agaaatgaaa ataaaaatgg 2183041 ataacttaac ctcatttttg tcttataaaa aacagctgcc tgctgaaaaa agaggatctt 2183101 agcctgtaag gaggttttat tagtgagaca gcaagaggtt cacgattttc tgctgcgttt 2183161 ttttcaagca aacagctgcc aaatcgtcga tcaaggctta ggctatatga cagtgcagct 2183221 tacagttgaa atggacaaac aaatcatgaa ccgccctttc tactggcatt ggcgcgagaa 2183281 gacaggcggt gatccgaatc caatgaaaat cacttttatt acagataaag aaaatgcgcc 2183341 aaaagaccta gatggtgaat ttatatattt tggggccccg cgtctttttc aaatattcaa 2183401 agctgttaaa caaaatggga gatttaccag aatgtatgag aaaattgaat cagccggagc 2183461 taaagtccca cttcagcctt ggcttggtat aaatgtcacg atttcatacc agtccgacat 2183521 gaaaaaggat aagttattgt cactaggtct tcacctagtc tctggaacga taattgaaga 2183581 ttttcaaagc aagctgaccc agttttcact gacgtctcaa atatgtgact attgcttcac 2183641 catttcacct atgatcaaac cagaaagcgg acttaagcgt atggaaaact atatttccaa 2183701 atccgctatg caggagccgt ccgactgggc ggaacaggcg gttaacaggt ggaagaatga 2183761 tatgacattg cttgataagt tttacgagca tatagaagaa aaaccagaag aataccatct 2183821 agaaaaacag gcgctgaaaa ccttgtatca accaaagata tcagttgaaa ttgaaaatgg 2183881 cggattgttt tatctgcaaa ataatatttc aagctaactt ttttaccatt cgacatcatt 2183941 ctcgtttttt ttgagaaaat acgattataa taaaggtata ttggaaaaaa attctggtga 2184001 tttaatggca aatgacttcc agagactaat gaagcataca ataagtcatg gccggactgg 2184061 ctgaaataca taaacaagta ttttaggagg agaaactgca tgaagaatgc aaaacaagag 2184121 cactttgaat tggatcaaga atgggttgaa ttaatggtgg aagccaaaga ggcaaatatc 2184181 agcccggaag aaatacgaaa atatttactt ttaaacaaaa agtctgctca tcctggtccg 2184241 gcagccagaa gtcataccgt aaatcctttc tgaatgtgct ataatatcac aaggaaggtg 2184301 atgacattga ttggccagcg tattaaacaa taccgtaaag aaaaaggcta ctcactatca 2184361 gaactagctg aaaaagctgg ggtagcgaag tcttatttaa gctcaataga acgaaatcta 2184421 caaacgaacc cctccattca atttctcgaa aaagtctccg ctgttctgga cgtctcggtt 2184481 catactttgc tcgatgagaa acatgaaacc gaatacgatg gtcaattaga tagtgaatgg 2184541 gagaaattgg ttcgcgatgc gatgacatcc ggggtatcga aaaaacaatt tcgtgaattt 2184601 ttagattatc aaaaatggag aaaatcccaa aaagaggagt agtgcctgag cagaggcact 2184661 aactcctctt ttgtcaataa ccatcgagac ggcccagtat atgaatactg ggccgtctct 2184721 tttttttgct gttattaatt tttatcctcg ctatgcgctt tttcattttc tttcacgtaa 2184781 ccatctttat cagtatggtc ctttttgatt gtcaagccgt tccactgtgt agcttcgaat 2184841 gagaattgaa gcttaatgga gttgccttga tatttatttt gaaccataag ccctttttca 2184901 tcttttgttt tatcatcctt gaattggatt tccatttgaa cctgatcgaa gtcagttggt 2184961 gtttttggaa caccatcata ttcaggagcg gttttaccat caattgttgc tacattgact 2185021 ttaccgcttg catttaagaa tttagggtca atttgttttt tgattttttc agcagccgct 2185081 gcatcatttt tagcagacat caaatacaag tctttaaggt tcgcatcatc taaaataatg 2185141 tttttcgggt agccattgcc gccctctttt ccaactgtca acaatgtcac ttcaaactgg 2185201 ctgaggaaat cttctggaga tgtattgctg ccgccgtttg ctttaaaatc tccataatta 2185261 agcgccatta gaacttcttt gatcgcaagt gatccgttat tttcaaattg gaaatccttt 2185321 gtcaacttat ctcccggctt tagatttgat aagttcacac tcgctgaatt ctctttagca 2185381 gataaatcaa gcgtacctga tgcaaaagta gcatcctttg atttaatgtc gttaaatgct 2185441 gcccatgttc ctcctccaac taaagctaat cctagtgctg cagaagcaac tcctaaactc 2185501 aatttctttt tcatacccat ggtaagctcc ccttttattg aatgatttta tatcgaaacc 2185561 tgttgccagg tttacaactg aagttaagta gacatggtgc tgtcctttgt atctgtttcc 2185621 aaggcttttg tctttctttc aatttctcta atggcgctgc tgatcgtcac aaaagcgtaa 2185681 actaacagca tcacgccggg aacaatcaat aatacagccg ttccaatcgg ctggctggca 2185741 aaatgaagca tatagccggc atatggaagc tgaaaacctg tgtattgcgc gcgaacattt 2185801 tcgtccgata caggcgctga atcagctgct gcattattat caccttttgt tttaaataac 2185861 aaatggtctc cttgctttgt tatgtcaaca attctgtggg tgaccgccgt atttgcatcc 2185921 tgcataaatg taataacgtc acctttttgg agctctttca catcagtgat ttctttgacc 2185981 aatattaagg aacctgtatt gaactccggc tccatcgaac ctgacagaac tgatttcagc 2186041 gtatacccaa acactgccgg ctctcccccg gatgaacgtg ttgaaatcac gacaagtgtc 2186101 agcacaataa taagagtaaa gatgatcacg tataaaatat tactgatcag cttcattgct 2186161 tttttcatcc tcttccccgc tttccttctg gtctgattga gtttcttttt ctttggttac 2186221 agcttcttga gatgtttctt ctttcattgt tttttccggt atatcttttt gtgttgtttc 2186281 attctccttt ttgacgtccg actttgtttc ttttttaggg actgtcggtt tttcatcgca 2186341 ttttgcaagc ctcataggct ccgaccactc aaatgtactg ccgtttgccg ggtagcctgc 2186401 cggtttatat actttaaatg cataaatgcc gggtttcatt tttttcttgg tctcaatttt 2186461 ataaagtgaa tcgccgattt gattggagac aaatcctttt tcgatcacgt tcccatcctt 2186521 taacggtttg cgggcatttt caagcttatg aagctcccac ttccactttg atttcttaag 2186581 tttctcacct gtattttcga gcacagcaaa taaggcgaaa ggtgagcata cagtgccttt 2186641 cgtatccgtt tgatctgata tgtgcaaatc actttgatcc cagcgtttat cataatggca 2186701 gtttttatct gtatgctgaa agtctttaca cgtttgaagt gagacatcaa atgtttcaat 2186761 atcatgaaaa gcagcgcttg tatcatcgga aaattgtaag catattgcgg cagtcagact 2186821 gaaaatgact gaaagctgaa agataagcag aactttcagt ttcgtcttcg ccttttgctg 2186881 attgtgaaac aatcgaaaca tatcttacct cctgtaaaac actgtaactt gatatgacaa 2186941 tcgttctctt taaagaactt cacaaataga gtataatcaa cgatttatag atttaaaaac 2187001 accgaaatcg ctcattttgt tcgtttaaaa gaatgttttc atcatattac aaagtcttgc 2187061 tcagtattgc tcattttttc aattttttag aaatttttgg gattgttatg tgagaattta 2187121 aatgcatatc ccattattat ttggtaataa taaacaaaga aagggtgaca gcatgatgat 2187181 caaacaatgt gtgatttgtc tatctcttct cgtctttggc accacagccg ctcacgcaga 2187241 agaaacaccg cttgtaaccg cccgccacat gtccaaatgg gaagagattg ctgtaaaaga 2187301 agcaaaaaaa aggtacccgc tcgcacaggt actgttcaaa caaaaagtat gggaccgtaa 2187361 aagaaaagat gaagcagtga agcaatacca tttaactctg agggaagggt caaaagaatt 2187421 cggcgttttt gtgacgattt catttgatcc ttatagccaa aaggtcaata aaattgccat 2187481 attagaagaa tatcaataag gtcctccatt ttttgaagga ccttattcgt ttatttgcgg 2187541 ttattttttc cgtttcagcc aaagtcggaa gccatagggt aaaataccga accactgctg 2187601 ggaaacaggc gtttttgttt ctttccgcac ctcttttcgt tcttttcgct catctctcgg 2187661 agtatctata tatttgacaa attgctgcgt catatattta acataatcat tcgttttcac 2187721 gtgatcacct catcattcaa ttattatgag tgttgtctca catgactttt tttataccct 2187781 ttacactgtt ttattctgtc catctcagca gttttttctg tttttggtca aacacgatct 2187841 gtgcagttct ttctgttccc gaatccgttg acactcttaa gttgatttct ttttgttctt 2187901 ttatcgatgt atcatgaatg taataagaaa cccgtccata tagaaattgc tgcgtaccct 2187961 cctggccttt ccgttcctct agaacatgcc gaatcgaaag aagcacccca ttttgaagca 2188021 aattctctcc tatgtataac tcttttgttt ccttctcaaa catgcagcgt gaaatatatt 2188081 gagcagcaac aaagttcacg attaacagca caagcgctga cacaaaaaga acagctggat 2188141 aaataaaccc tcttgtacga tacattcacc cccctcctaa atacgaatag actggaaaag 2188201 cagtttgata cactttttgg tcttcactct caattttcag caaaacaaca ccattttcaa 2188261 tatcagcttt catggcagta atatgatcta aaatcggaac atgccctttg ccatccactc 2188321 tttttcttat cattgaatga taaatgtcaa aacggatgtc ttgtccggaa agattggtgc 2188381 agattaacac gctcccatgc tcggctgtct taactgcctg tgattccttg cattcattca 2188441 tcatctgttc tatcgaaatc atccattcct gctgtgtgaa accgtcatgt tcctgctgtc 2188501 gagacaaaaa cagatggata atcgcagcta acgatcctga tatgagcaaa aagactgaga 2188561 gcgaaaataa tacgttaaga agcgtgtagc cattctgtct gcaaaatgct gaggcaaaat 2188621 gatttttctt tataagctgc ggctttgata catacgtttt gatattcgcc ctcctcctcc 2188681 cacttcattg catagatatg attgttcttt gtaatcgttt ttgacgcggc tccttcacca 2188741 ctcatgacat atttgctaat gctctcattc atcatctgat agccaatttc tcgtgattcc 2188801 gccatttttt catcagccat cagcttgtcc cacaagggga cgactgtcag cagcacaaac 2188861 agccacaggc ttagcgcaga cattgtttct attgtagaaa aacctttatt ttctctccac 2188921 attgactctc ccgctcccta gataaactgt tatgtcataa acggcatggc cttttactcg 2188981 tatttttccg cctgcattcg ggtgcccttt ctcattaaat tccaaacggt cttttaatgt 2189041 cagcagttct atagaaagtc ccgttgcata cggacgttca ataaccgtat caccaatgac 2189101 taattgatat tcttttttat gaaagagaat ttttgttctt tgttgacggg aaatagcagt 2189161 ctgctgtgtg agcataatat catttttcag ctgacttgct gcctgtcgga cagctgtatt 2189221 gtcataagca ggaggaagtg tagtgaagac ggccaccagg aggatagagg caaggcttaa 2189281 cacaagcaaa ctttctaaaa gggtaaaccc cttctcctcg tttaatttaa tgttcaacct 2189341 taacttctcc gccggtgatg ataatgcgct taccatttgg acagacagca tcctttttca 2189401 catagccctc tgactgtaaa tcggcaaggc tcggagtttg tccttcatga tcaagctcaa 2189461 atgcagtcat ttgtgcctta accatgtttt gtaagccttc acagcccttt ttttgaatgg 2189521 tttgattatg tttcgtgacg ttcggtatcg taattaaaag caaaatcgaa ataataaaga 2189581 gcacgattaa catttcaaca agtgtaaatc ctttctcatt catcagcctc ttcctttcac 2189641 atttgattca tcatctgata cataggcaca agcatagata aatacacaag taagatcatc 2189701 gctgcaacaa atccataaat cattggctga aggatgcctg tccatttttg cgctttgtgt 2189761 tccagccgct gtaatatgaa ttggctgtat gtgaaaagct cccgatccaa tcggccgctc 2189821 agctggccgt gagatatgac ttttgataaa tcagtttcat aaaaaaggct tccacaaata 2189881 gcggattcaa ttgactcacc ggcttttagc cgttcaatca attgttcagc ctcgcagcgg 2189941 tagaaaggga gaaacgtttg atgtttaaat gcattaaggc tgtcataaat tgagaggcct 2190001 gattttaaaa ggctgcttag ctgcaaagaa aaaaagtagc tgttaaacag ctttacaagc 2190061 tttccaacca aaggaatcct gatacaaatc agcatttgcc gggcaggtga ttttttctta 2190121 aacacaagcc aataataaat cccgatacct gctgtaaaaa gaacaagcaa aatgatcaca 2190181 agatcaatat gctgaaaaaa agcaaaaagc atatcggttg aacgtgaggt ttccatattc 2190241 atcgattgat agataccgga aaactgagga atgatgatgg actgtaacat ataaaacatg 2190301 acagcgaccg taaagatgag gaaaagcgga tagcgcagca ctcttttcag ctggtctgcc 2190361 tgtgcaattt ttcgttccag cagctctccg ctctggatca ttgaagcagg cagttcacca 2190421 tgtgtttcag caaaataaca aatacctacg gcttccttat gaaatgacaa actctttagt 2190481 acttgataaa acggagcccc ttccctcaaa caagtgaccg aatcagtcaa gtcagccgcc 2190541 tgcctcttat tcatctgaag ttccatcagg cgtaatccat ccagaagtgt atatccgccc 2190601 gcagtcattt caccgagcct ctttaataac ctggcttgat cctttaacaa ccagactttt 2190661 ctaatctttt tcatgataaa cccaccggtc atagttgttt gtcgttaaat agccgagcgc 2190721 aattcctttt ctgataattt gacgaagcgt ttgatattgg taatttgcat gatttccttt 2190781 tgcctcctgg atacattgct gaagattttt cccgtataga agctcataaa cgctagctct 2190841 cctagtattt cgtgactgtc ggcaatacac tgatgaacat ccgttttcac aaaacgggca 2190901 agccaaatca accaagcgct gagccgctat tgcaatgaca gtctgttcga tttcattcat 2190961 attgataccg aattcaagca gtctgtaaat tgcgcccttt gcgtctctcg tatgaaggct 2191021 cgttagtacc agatgtcccg tcatcgctgc ccgcaccgca atttcagctg tttccgcgtc 2191081 tctgatctca cctaaaataa tcatatcggg gtcatggcgc aaaattgctt tcagacctgc 2191141 ggaataagtt acaccggctt tttcattcac ctgaacctga agaacatctt cgtcccttgt 2191201 ttcaacaggg tcctctaatg tgacaatatt tcgattaaag tgtttttttg catattgaac 2191261 gagagagtat aatgtggtag tcttccctga accagtcggc ccggtaaaaa tgagcatgcc 2191321 atgggaatgt tttaaaaacg agagtaatgt ggctcctgtc ttcggaaata gcgacaattt 2191381 atcaatcgaa gggatattgt attggggcat cactctgatc acgaggcttt cttcattaat 2191441 tgtgggcagc gttgacattc ttaaatgaac atttccctct ttcaacttta acgtaagcga 2191501 accgttttgc ggctttcgcc tttcacctat atccattgct gaaagaaatt taaaatgtga 2191561 aatcagtctt acgcactctt cttttttcat gtcccttttt ttcagcaagg catgatcgac 2191621 ccgaaaatga atgatagcgt cccgctccct cggcacaatg tgaatatcag aagcctttgt 2191681 tagatatgcc tcttcaatca agtttttgct taccttttct attgaatcca atttgattcc 2191741 ctctcctttc aacgcatatt gtagaaaaag aagaaaaggt aatcaaacag ggaaaacgtg 2191801 attttgtgag atgttatatg ctgaaaaacc aattctttct ggcaagaaaa aagactttca 2191861 actgaatgta cccctgtcat tataattttc cctataaata aaaaagcaga catggtcacc 2191921 atgcctgcta gattccattt tcattatgct gttttcgctt attgaccagt atctttctca 2191981 acggaaagat cgcctaatgc aacaataccg gtcatttggt cattttcaag aatcgataaa 2192041 ctgcggattt aatgctctgt cataagcccc ttgacatcgt atccggtcac cctgatatgt 2192101 ctggtgaaaa agcggggcac gctgcacaaa atatgaaaca tcctatagag tccgcctttt 2192161 tcgaggtttc tttttcttct tccgctcctg cagcatatct cccgtccagc ctttttttct 2192221 caaatagaga tagatcagaa ctgtagatgt gacaatcaat aagagggaaa agagatatcc 2192281 gtatttccaa ttcagttccg gcatcactga aaagttcatc ccccataagg cacccagagc 2192341 tgtaatcgga gtaaaaagcg tcgtgaaaat ggtcagcgct tttacaattt cattccccct 2192401 atgtgaggta atgacttcct ctgaatgcag cagattgtta agctcccctt caaattcgct 2192461 gatgtatgta aatcccctgt caatcttcag ttgtgtccgc tgataatcct ttttcccttc 2192521 attttgaggt aaaaaggttt ctttcaacgc catttcaatt tttttagcgc ttaatatcaa 2192581 atttttccaa atcatcagtt catggcgcag gagatggacg cggtttaaaa tgcttttgct 2192641 attgtcgtct ttaatttgcc atctgagctt tctcagcttg acttcaaatt catcaacacc 2192701 gattaaatac gcattcatta gttcgccgag aagaattaaa aacccctcta tcgcattgtc 2192761 cgctctttcc atttgccgaa caacttcttt gcctttaatc tctctcaaaa ttgaaaagtc 2192821 aaagttgatt gtaaaaaaat attgtctggt gatataaaag tgaaaaacag tatggtcttt 2192881 ttcttcacca agcccctgat cataaacaat cgacccaaat actgcttcat tttccgtttc 2192941 agttgtatct actcgcaaaa aattaacgtg atggttattt tcaaaccact tttcacactg 2193001 aggccagtga gaaaaatgga ttagatctct tgccttactt ctttcttgag gccccatttg 2193061 gtaccaaaac caatcctttc ccgtatgtgc cttcatgtca agctcctcca aacttttgtt 2193121 ctttattctt taattgccca ataaccgcgt cactaaacca gtctgccgct tcaacacatg 2193181 ttttatgagc attttcaggt ggtatggaat gtagaaagac atcggaaaag ggaggtgcat 2193241 gccttccttg gagaaggcag ttgttttgga atttatcaat ttactagcag tcgctattct 2193301 cattttgtta acaggatttt tcgttgccgt agaattttca atcgtaaaag tgcggcgatc 2193361 caaaattgat cagcttgtcg caaaaggaaa gaaaggtgct aaagcggcaa agcatgtcat 2193421 cactcacctt gatgaatatt tatcagcctg tcagctgggc atcacagtcg cagctttagg 2193481 actgggatgg cttggggaac cgactgtgca aactctgctt cgaccgcttt ttcataaagc 2193541 aggcttaaat gaatcgctta cccacctgct ttcactcgtc atcgcatttt tagtggttac 2193601 gtatttaaat gtcgttattg gggagctggc gccaaagagt ttcgccattc aaaaagcaga 2193661 aagcattacc ttgttgttcg ctaaaccgct tatttggttt tataagatca tgtttccatt 2193721 catttggctg ttgaaccact ctgcccgatt gattacagga gtgtttgggc tgaagccggc 2193781 atcagagcat gagctggctt atacagagga agaacttcgg gtcctattgg ctgaaagcta 2193841 taaaagcggc gagatcagaa aaagtgaatt aaagtacatg aataatatct tcacctttga 2193901 taaacgaatg gcaaaggaaa ttatggtgcc gcgaaatgaa atggttagtt tgtcactaga 2193961 tgaagactcc atttcaaatc ttcaggaaac agtcaagcaa acaaaatata cacggtaccc 2194021 ggttgtaaga gaggataaag ataacgtcat tggcgtgatt aatatgaaag aagtgctgtt 2194081 ttccatgctg acgaaagatt tttcaatcaa gaagcatcaa attgaacctt tcgtacagcc 2194141 cgttatccat gtaattgaga cgattcctat ttataaacta ttgctgaaaa tgcaaaagga 2194201 acgcactcat atggcgatcc tcatagatga atatggcggg acgtccggtt tggtcactgt 2194261 cgaggatatt atcgaagaaa ttgtaggaga aatccgtgat gaatttgatg cggatgaagt 2194321 gcctcatatc cgcgaacttg gaaaggatca ttacttgtta aatgcaaaat tattaatcag 2194381 cgatgttaac agcctgcttg gaaccgattt atcagaggct gaagtagaca ccttgggcgg 2194441 ctggtttttg acacaaaaca tagacgctga gcctgaaagt gccatagaat atgatggcta 2194501 ctcttttaag gtaaaagaca tcaacagcca tcacatttta tttatagaag ttaaaaaagc 2194561 tgaatagccc gtgaaaggct gttcagctgc tatctttcaa gataaacatg gcaaaggcat 2194621 caacactctt ttattttaaa ccctttattg gccagggctt tagcaagact ttgctctgtt 2194681 ttcacattcg aaaaatccag acccagcttc acgacagttt gggcaatttc cggcctgatt 2194741 cctgaaataa tagtctcaat gccgagcaat ttggtgctgt caatcacttt aaaaatttga 2194801 taggctacca tggtatcaac gataggaacg cccgaaatat ctaaaaataa atacgagagc 2194861 tttaacgctg agcactgctc cagcacagac tccaaaatcg tcctcgctct gtgcgtatca 2194921 atttcaccga caagcggaag aatcccaatt ccatcagtaa tcggcataat cggcgcactc 2194981 aattcattaa tcatttcttt ttgcgcgttt aattgtatca tggtcacctg gtgatattct 2195041 tccgtaaaca cttcgatgat ctcatcaatg ttttgattca agatccggct ccactcataa 2195101 aattcctgaa tgctgatgtc ttgagaagaa gcttcgctga atttatgaat ccattcaaac 2195161 atgatgtgcc tgaaagtgtt aaactggccg acactttgtg taaccgtcac ttcatgaacg 2195221 gcacggtctc tggcgcattg aagagaccac cggttgagct catcctctac gtcttctttt 2195281 ctaagggatt ttgctacgat ggtcaccaat aattcatgct ggtcttttaa cttttgttct 2195341 agtttttgct gatctttcgc tgaatacagc cagctgccgt ttgacgtaca aacttccagc 2195401 cattgttgcg taatatcttt tttgtgctct gttaagtgct gatcaagagc tatcatctta 2195461 atgagttacc tcctgttttt gaaaaatgta cgctatatat gtataacgcg tctgccttta 2195521 cacatactat gtttagattc aatgggctat agccaagcgg taaggcaatg gactttgact 2195581 ccgtgatcgt tggttcgaat ccagctagcc cagtttctga acaggtgaaa aaccgaagat 2195641 aagctgattc gtataaatca gcggatcttc ggtttttcat catgcagatt gatgaaccgt 2195701 tttcttcttc gataacttca acagttctcc cgggttataa ccaatcacca gctttttgtt 2195761 gtctactaga atcgggcgtc gcaaaagctt cggcttctcg attaaaagtt ccagcacctc 2195821 atttaccgtc atttcttcaa tgtttaaatt taaatttttg aaagtctggc ttcttgtcgc 2195881 caaaatttca tcaattcctt ctgtcgttaa cgataaaatg tactttaatt cttctcttgt 2195941 cggggtttct ctgaataagt gccgttcgtt aaattcaatt tgatgtgctt taagccaatg 2196001 ttttgttttt cggcatgacg tgcagcttgg atatgagtaa aaagttaatt gttgttccat 2196061 tcgttttttc ctcctcagtt aaccatctct ttgtagaata actacccgga tcatttttca 2196121 tttaaaccat ttacagaact tttttcggat tattttttaa aaaacattca tacaatagaa 2196181 aacacaatca aagggacaaa ttccatttgt atattaataa tgaaaatgtt tacatttcta 2196241 ggtgtgatct attataataa cagtcagagg gactctcggg aggggataaa aatgaatcgc 2196301 atgttccggg tgttaggatt ttggacggga atttttgcag tcatgtttta tttaggtgat 2196361 atgaaagatg cttccctttt attttttgga cagacgatct tatttgtgtt tctatcgtat 2196421 ttgaacttaa ccgaacgcat gtatatttat atttttggcg cttatttaac aattttcttc 2196481 gccggcttta catattactc aatttttatt atggtgcccg gcggcggagg ccattaaatg 2196541 cagaaagaga caaaccttat cggtttgtct ctttttttac aatgaaaacc catttaaaaa 2196601 cggattttga tcctgctcag tcagtacgtc tgtttcaggt ccatggccgc ttaacaccag 2196661 cgtgtgttcc ggaagcgtaa gcagtttttc atgaatggac gtcagcagcg tctcttgatt 2196721 gccgcctatt aaatccgtac gtcctatacc gccttggaac aagacatctc cggaaatgac 2196781 caagtctgca tctttcacgt agtaagacac actgcctggt gaatgtcccg gcgtaaataa 2196841 tgtttccaaa tgaaacggcc cgatattcaa ctcaccgtcg ccttcaatta gatgatctgc 2196901 aggcttagct gtgacttcta tccctcgcag catgccggag ccgtttaaag aagcgtccgc 2196961 aagccaattt ttttcatttt gatgcaggta aacagggata tcccattttt ctctcacttc 2197021 atcaagcgcc ccaatatggt caaaatgggc atgtgtaagc aaaatggcta aaggcgtcag 2197081 ccctttttct tttatgtatt gattgatttt atgtccctcg ccgcccggat caaaaatcag 2197141 acattgatca tcactgatga gaaaatatgc gttcgcttga atcggcccta ctggcattcg 2197201 tctccatttc actattatca cctctttctt ttttatgctc ttattatgag ggtttttgaa 2197261 aaaagattca aacaatcgca atgaaaacgc tatcgacaaa cctataaaaa acaggtagaa 2197321 taaaactgga aagaattgca ggtttttcaa tgtaaagggg gctgtgttat gttacttgtc 2197381 gtgattttcg gccttgtcgc tcttttcgct ttatggggag tcttgcgttc tgttagaaat 2197441 aaaaatatac tcgggttttt attagccggt gccaccttat ttgtctttgg atggtttacc 2197501 gtgatgaccg taataaacag cgggtatcca accgcacatt aaaacctgta tccgatcgga 2197561 tacaggttta tttttatggc tgtaaatgtt tattgacact ttctattttg ctctcaagcg 2197621 tcgttttttt gtcacgcctg tcatcgatac ggatattcgt tgccactctg tgcaatcctt 2197681 tttgaaatgg cgcttcgtga attgcctgaa taactgcaaa aaggtcactg agttctccct 2197741 cgatcagcgt attcatcggt gtcagctgat atttgatttt cccttctgct tgatatcctt 2197801 ctaatatctt ttgcacatcg gctacgtaag cactgacact gggtgtttcc gtaccgattg 2197861 ggataatggt tacatctgcg atagccatcg ttattccatc tccttttgat caatgatgag 2197921 ttgcttcgtt tcatgtgatt tcaataaaat aatttgctca aaatgaaagc cgtataacgc 2197981 atatttcccg ttcggagata tttgaatcgg ctccatttcc cgcagagaca caagatcttt 2198041 tgtctctccc gatgctacat tgattgctgc gagcttatat gcatcgccgc tttgtttgaa 2198101 tgtataaaac aggcctcctg cttcatcata gtcatactcc attggagcca aacttgtata 2198161 tttcgcttgg agcggccatt tcgctgtaac aggtgatgtt gattgcggcg ttttaaactg 2198221 atacgtccct tttcctccgg aagctgattt gacagtaaaa ctcatttgat ggaaagaatc 2198281 gaagaataga acgttatcct caagcttctg ttccgtctta gaagctgtat cgaacgtata 2198341 taaaggccct gttttatcgt ctctaccctc ttttacataa tcaaatgtat ttttggatgt 2198401 ccaatgaatg aacggaacct gtactgggct taagaaagat tcgtcttttt tagcattcac 2198461 ctgatatgta tggaaatccc agttttcatt gaattccgtc accatcattt gataaggatc 2198521 atactgattc caagcagctt caagctcata cgtttcgtaa tctttttcgt aaagcgtctc 2198581 tccttctgca ttaagcaaaa ccactgccgt cttttggcta tgtgtgattt gcagcagaat 2198641 catctgctcc ctcgcattga tttgaacatc aacgatttga ccatccgttt gatagagctt 2198701 tttcgctttg cctgtaaaga tgcggtacgc aaaaagctct gttttcgtcg gattagacgc 2198761 agtatataat attgtgctgt tattcagcca gccttccgcc ccatccgctt tttccgcgga 2198821 aagcggtatg atgtcttttt tctcatcttt tgccgccgat gcctgttttt gctgctgatg 2198881 agatggttcg catgccgata aactaaacag caataccgcc agcagaataa aacaaactga 2198941 tctcatcagc attcccctcc gatcatcttt attctctcat atttgcttcg gcagaaaaaa 2199001 gaaaaagttt cagttactca tgaaaaaata acgccctcca caagataccg cttgtggcgt 2199061 tatatatgtg tgaaaactgc tgaaacggca aaggattttg gccttttcca agttccaccg 2199121 tatacccttc cttaaaataa tggtgaataa accaatcacg aaatccagca tagctgtcta 2199181 tatcccttac tcccttataa atgttcccgc ttaactcctc aaactccttt atgacggcag 2199241 cagattcctc aggctcaagg cctttatagc cccaataaat ttcttctcct tgagtatgaa 2199301 gagccagcag tctgtcaggc ggattctccg tgatcagccg gtacatcgca atagattccg 2199361 gctccgtaag cggagagatt cccggaaaat cgcggtagct gggtgctgtc ggttttcggt 2199421 atttttcaat ttcccataat gatggaaatt gtttatttaa atcaaccccg tttatattcg 2199481 ccttccattc attaaaattt ggacgatgtt catttagcct ttcgagttca tctcttctgg 2199541 ctcccatgac ttctgatccg tttaaaacaa gatcaacgcc atccggattg acaagaggaa 2199601 cgagggataa ggatgtgctg ttaaacagct ttatgggaga aaagccaaag aaaggcgaat 2199661 tgcagcataa tgacatacag tattccttaa accattttag caggacagac gttgtaatcc 2199721 actcattcgc atgaaatgac gcgttcatat ggaccttttt tacggcatgc tccccaccag 2199781 ccttcagctc ccagataggc ctgccgagta cagaacggcc aatttcccgg catgagacaa 2199841 acggaaaaac atcaataatc ttctttattt ccttttcaac agctgaatca tcatagattt 2199901 tctcttgctc aatccagcta tctgaaagtt tcagctgccg aggctgtaaa aagcgcttta 2199961 tgtcctgaat ggtttgaagc tctttgccgc tatgctcctc tatcacataa ccagggcaat 2200021 acaattgatg tttttgtgcg gagcgatttg cacttttaag caattcctcg tctatcttca 2200081 gttctttcgc cacattggcc aaattgttct tgatctcagg tttcaccgta ataaacgcca 2200141 tcatcatccc ccttttttgt tactatatga cagcgtattt aaaaaaagaa agcctcccgc 2200201 tcacttcgat gcgggagaca ttgtgattat gatgcctgat caagcatttg tttttctttc 2200261 cgctttgacg aattgtccag ccttttctgg tcataaaatc gcaacaaatc cccataaatg 2200321 atttcatcag aaagtgatag ctcctgtttt gctttatcag caaatgcttc acattgtttt 2200381 gtctcttcta acggttttcc cgtctctttg tcataacacg caccgtctgt ataaacaacc 2200441 tgatctgtga taaagctccc gtcccggagc accgtgaagt ccagtttttc gtctgaaagc 2200501 agatcgttgc cgaattgaat ttgatctttc gtatcaatcc ctaaaagatt catcagcgtc 2200561 ggcctgatat caatctgccc gcctactgtt tcaatggttt gcggcttttt atcagtaata 2200621 cccggaatat gaatgaccag cggcactttt tggagctgta cctcttcaaa tggggttatt 2200681 tcttttccta aaaactgccc catcgcttca ttatggtttt ctgatatacc ataatggtca 2200741 ccatataata caataacaga gttgtcgtat aacccgtctt ccttcagctt ttcgataaac 2200801 cgtttcagcg cctcatcctg ataacgcact gtcggaaaat atttatttag cgtctggctg 2200861 tttgaatcat attcatcaat caattgatcc tcttcatcaa gatcaaacgg gaagtggttc 2200921 gtcagtgtaa tcagcctcga gtaaaacggc tgaggcagat ttttcatcag ctctgaggac 2200981 tgctcaaaaa attctttatc cttaagtccc cagccgactg aattttcgtc agttacatca 2201041 tacgagttaa tatcaaaaaa cgaatcatat ccaaatgagt cgtacattaa atcacgattc 2201101 caaaagctct tattattagc gtggagcacc gctgaatagt atccgctgtt tttcaaaatt 2201161 tcaggagcgg ccatatattg attgcccgca ttcgtaaaaa atacggcacc tcgtccaagc 2201221 ggatacagtg aattgtccac gataaattca gaatccgagg ttttcccctg gcctgtttgg 2201281 tggtaaacat tattaaagtt gtagctctgt tttataaagt cattcagaaa aggcgtgatt 2201341 tcttctccat tcaatttttc attaatcacg aagctttgcg tcgactctaa ggatacgaga 2201401 atgacgttcc ttccttttgc agcgccgaat aagcgtttgt tggcatcctt cgcattagcg 2201461 gttacgtagt tttcaatctc cgtcaggctg ttgctgtctg ccaacgctct ctgtgcggat 2201521 tgctttgact gaagaacgcc atcgtaaata tgaaaattaa acaggctaat gtttttaaca 2201581 agcatttctc tgtcaaatga gcgtgtcaat agctgaggtc tttccgcctc agacaagccc 2201641 aggttgaaga aataaacaga agcaacgaac aaaaaataag ccgcccgttc atttttcgtt 2201701 gagggaatgt ccgattgaaa agctttttgc cggatgtgaa gccatattaa aaccgcaata 2201761 tctacagcta ataggaggtc tgtcggctca agaagtgttc cgatgctgct tccgagatca 2201821 cccatattgc tcgtttgaaa aagaacaggg attgttaaga aatcattgta aaaacggtaa 2201881 aaaaccatat ttgccagcaa tacaaacgtg acaagacagc tcatcgcgat aatgtagcga 2201941 tttctgtttt tgccttttaa aaacaggctg aggccaaaaa taagcaacaa aaaactcaat 2202001 gggttgataa acagaataaa ttcctgtgtt agattgtcga ttttaatatg aaaactggtt 2202061 ttgtaaacag catacgtttt cagccacatc aataaaatgg caatcagcat aaatgaaatc 2202121 ttcgaaaaaa acgtttttcg catttcaacc tcctatgcag cacgctcaaa aaaatcagtc 2202181 tattcccaac attctcatta acacatcaaa ttaaatctta acctgagcac aacaaaaaat 2202241 caatttcatt tacacaattt taacaatttt gatgtttcag ccattcattt ttagcgatcc 2202301 aagcgcctcc gataacgccg gcatcatttc caagtgctgc gattgaaata tcagcagctt 2202361 gggctgcccg cggaaacgcg catttgcgga atgttttctc gacttttgat ctcagcagtt 2202421 ctccggctct cgatacgccg ccgccaagaa cgattttgga tggattaagc gagcttgcca 2202481 aatttccgag caccaaacca agatgcttgg ctacataatc aaccacctca agggcaattt 2202541 catcattttc acccgccgct tcaaacacat ctcgcgctga caattgttcg gttgctttta 2202601 aacgtgtcgt ctttttagca tttgctattt tttcttttgc aattcttaca attccggttg 2202661 ctgacgcaat tgtttcgata cagcccgttt tgccgcagtt gcagggcgct ccgccttcag 2202721 ggatgctgca aatatggccg atttctccgc cggcgccatt tataccatgt acaatttcac 2202781 catttgcaat gatgccgccg ccaactcctg tgccaagcgt cacgagaatg acgtcttttg 2202841 cgccatcacc cgctcccttc cacatttccc cgagcgcagc aatattcgcg tcattttcta 2202901 taacagctgg gatgccggtt tctgtctcca gatggttttt caaagcataa tttttccacc 2202961 ctagatttac tgtttcataa accactcctg ccgccatatc tacagggcct ggtgcaccca 2203021 ttccgatgta tttgatgatg tgcttcggtt tttgcagctc atccagcttg ctgtcgattg 2203081 tttttgcaat tgtgacagta atcgtgtcgc cggttttatc tgtcggaact tcccacttat 2203141 gctgaatttc gccatattga ttaataaaag cgagtttaat cgtcgttcct cccaggtcaa 2203201 tgcccgcaaa ccatatctcg tccattttta tcaccttagc ctttataaaa atctcttccg 2203261 ttttttgttt gttccaattc ttttcgaagg acagctgccg ctctggccca ctgctccttt 2203321 tcaatcatgt ggttcatgta taattccttt aattcatcca gcataaactc aatttcaagc 2203381 tctctgtctc caaaataaac aatgtggcca aacgttttta acagctgctg cacatcataa 2203441 aatgtattca ttttcctcac catttcttga acttaactat cataagcgta ttcataagga 2203501 agcggtcagt caagaagaaa acgctgacaa aaaagccagc ttcctttcca tattccacct 2203561 ctatgattct ttattgtttt caatttgccg ctgcagctcc ttgtagcgct gctccttcgg 2203621 cttcagtttc acagccgtct ggatggcctt ttctgcttgt gcaagctcat ttttttccgc 2203681 atacaataac gctaaattgt aataggaagc atggtcttta ggttcttttt tcactgctcg 2203741 ttccaaaagg gaaaccgcct gatcatattc gccgatttga atatcagaaa cagcaagaat 2203801 tttcaaaaga tcggcagagg catctttttg cgctgcttct ccgttcagca attctgttac 2203861 ttcttcatac tttccttcct gatacagctc gcttgcctgc tgaatcagcg ctgactcctg 2203921 gtgtgaaggc gaatgcaatc cgtaatataa aaatccaaca gccaaagcaa tcagcaaaac 2203981 cgctgacaac aatctttttc caaaggctcc ggctttaggc aaccccagtg ctgctgcagc 2204041 gaaaaagccg ccaatcaagc cgccgatatg tcctgaatta tcaatattcg aaaccgcaaa 2204101 accaaagccc agattgatga taataatgac aataatattg gttcctatag ttcttaaaaa 2204161 catttttcga ttagacaaag caacatacag taatgcacct aagcatccga atatggctcc 2204221 tgatgcccct gccgaaggat acgggctgaa cacaaaactc gcaatcgaac ccgtaatgcc 2204281 agcagccaga taaatcagca aaaatctccc cgatccatac atccgctcaa ccgctgtacc 2204341 aaccgaccat aaagccagcg tattaaaagc taaatgcgct atgccgatgt gaagcacgat 2204401 cggtgtcaga agccgccacc attctccttg tgcaatcagg ctgttttctt ttgctccaaa 2204461 agccaccagt gtctccgtat tagtgctgcc tccgtttatt tcgagcaaga aaaacatcag 2204521 gatctgaagc gcaataaata aatatgtaaa agtcggtttt ccgttttgaa aaaccgccgc 2204581 ttcagttttt ctctgttctt cttgtttcag cactagcgaa aggaagcgtt ctcgcgccat 2204641 ttgcgcgttt tcaaacgaag cgtgttcctc tgaacaatct tctgtacgaa atgatggaaa 2204701 aaccgcttga agatcatctc gaagcatcgt tcctctaacg atcgccggct caactgacac 2204761 agttcccttc tcaaaagttt tttttgcaat ctcttcccag tcatcaactg gggcttccgt 2204821 tgaaaaaaac acgttcagca gcttcatcct tcgtctgccc aattgatgtc tgactcgttc 2204881 tactcgttcg gcctgctctt cgatgtctct aaccatttct tgacggaaat caagatcgtg 2204941 cttataaaga cgaactagat catgagagga cttgtccggc gcttccagcc atatttcatc 2205001 tgactcaccg gcttgtatga cgccataccc gctattcacc aggtgcgccg caattttcca 2205061 atatgtatac tccagcaaaa acatgtttac cgctccaata gttttttttc attataacag 2205121 ctggcgctcc gaaacgccta ctgaaagcaa aaaatcccgt ttttcacggg attttagaaa 2205181 gcttgctgta taaacttatt gcggataaat ggaattctta aaaacaaatg gataaaagac 2205241 cgcctgattc ctggctggct gagtacagta ttcataagac ggtagcgatt ttgataaaac 2205301 atgacggcag aaaccgcgaa aatggcatat atcaaaagtt ttttcatgat atccctcctg 2205361 ccaatagggt ttgttattct accttattta ttctcgaata agggacagga aagttatgaa 2205421 aaacaagaaa taatccgatc ctctgttatc agcttatgta ccgggatgtc atgcggcaga 2205481 cggggtacgt gcgcaaacaa ctggcactcc aaaagcaaag agactgtctt cccttcatat 2205541 tcacttaaat agcgatcata atagccgcct ccaaagccga ccctaaaccc gttaacatca 2205601 aaacaaacac ccggaacgat catcaagtca atttgtgatg ggtttacttc ttttgttttt 2205661 tcaattaccg gctcgagcag tccggcgtac acggtttcga gctgatcatc agtctgatat 2205721 gtgcgaaatt gcattttctt cgtgtccgga tggcattttg ggatgcaaac ttgtttccct 2205781 tcttcccaag cctgctcaat gacaggacgc gtcggtatct ctaatcctct ggaaatagtg 2205841 acggcaatgg tgccggcatt ttgccactcc ggcagagaaa acaagtactt atacatacgt 2205901 tccgtttttt gaagaatatc ttcatttgat aaagcagaca gtgcctccag cgtctttttt 2205961 cttaattgtg atttcatctc tcatccccct cggaatagaa aaaaagccag aacctttttc 2206021 aaagctctgg cttttttctt acacctcaaa cagcaaagct gttattttgt ttcacggtgt 2206081 aacgtagatt ttttatcacg tgggcaatat tttttaaatt caacgcggtc tggattgttg 2206141 cgtttgttct ttttagaaat atagttacgc tcaccacatt cagtgcaagc caaagtaata 2206201 ttaacgcgca ttattttccc tccaaactaa aatcatttac ttattcagac ttatatataa 2206261 taccactata atggacggaa tgctaggctg tttttcaatg aattgctgaa ttattgaaga 2206321 tacgctcata aagctgcaaa tatgatgaca taatgagtcg ggggtggtgg agcttgaaca 2206381 cttgttgtct gccagcttct tttatccggc gggctttttc ccggtctttt aaaaaactgt 2206441 ccagcagatc agcagcttcc tgtacgagcg taaaatcagc gatgattgcc gttttgtcat 2206501 gaaccgcata atcacaaaaa ccacctgact gagaaacgac agtcagcaca ccttgttcca 2206561 tgctttcttg cgcggcaagc ccaaacggtt cataagaact agggaaaaca gccatttcac 2206621 agtgagacag taacgttctg atatctttcc tatttagaaa cggcagaaac atgacgcgat 2206681 ccttcaggtt atatgccgca gccaatttct catagcagga cagagacggc ccctccccag 2206741 ccagcactag atagaggtca ggctgacgct gcttcaagat ggcaaacacc tttaacagct 2206801 gcgataatcc tttttccgga acaaaccttc catatgaaaa gaggaatctt ctattcatgc 2206861 ttctcgggat tttccccttc tcttcctcca tagatgcagg gcttgggata acggttattt 2206921 tcttatgtgc cgccttatca agagaccgct tcataaatgt gcttaatacg atcaatgcat 2206981 cagcggattc tataaggagc cgttcggtca tgagcctgta tgggtgtggg gcttctcggc 2207041 acaccttctt cctttcgctt tcaagaccgt ggattgtcgc agcaagcgga aggccaagcc 2207101 gttgtttcaa atactgggcg gcaggggcag ttgtgtcatc atgggcatga atcagatcaa 2207161 agcgtttatt gtgtgataac acatggcgaa ccattgtaaa gttagcatca gctatgtaat 2207221 cttcaaactt cgcatacgaa aacagctgcc cgctcggagt aaaaaccgta atgttgatat 2207281 gagggtttaa ataggaaatg aggcggttta aatggacacc gagcccgctt ttcggctcat 2207341 cgggatgttc gggtgaaagc atgagaatgt tcaccgttct ttttcccctc tcccataaca 2207401 ggtgtatgca gaaaattgcg cctcccacct ggtgtgcgct tcttcaatct gaaaactgtt 2207461 tatatgacga atcccatttt catcaagata gatgtcgtct gtaccggcaa gcttgagaga 2207521 gacattcatt gaattcacaa ttctgtattc agcccgatat acagcatcac cagccgcctg 2207581 tctaatcgtc cattctcctt tatcatacgt tgtgcgtttt gtcctgacag cttcaatgtc 2207641 ttttcttttg atgacaatgc gcaattcttt tatcatatcc tgcgtttttt cgaaaaggac 2207701 cgcttcagcc agccgcattg tttcttctga gatttcccag cttacggtca aggtgtgagc 2207761 gttttgaatg attatgtcga atgtgtccct aaaaaaggaa agcttatgtc gtatattata 2207821 gggaaatggg tgtttatcca tggactccta acattctcct ttccaatcgt tcacttcgtg 2207881 ttcctattaa accattacat gaagaagaag cgaagaaaga tttctcgaca aaatctcgtt 2207941 tttttcgcga attcctttag aaactattgg ttttatggta taaaaaagaa ggataaaaaa 2208001 agaatagaag gtgatgaaac gtggaaattg ctattattgc gttgtttatc gtcagtatag 2208061 cgctaattgc attctcatat tctcaaagag acccgatgaa agatgtagaa caggagctcg 2208121 aaacactgca gctttctgcg atgcaggaaa tttacaagct caaaaagaaa atgacagtgc 2208181 ttgaggaaga attactggaa acaaaccttg tcattcgcaa atcaaagcag aacgacatca 2208241 atcaaaaaat cgctaaacaa atactttcta aatataataa cggtatgtca gctgaagcga 2208301 ttgctaaagc tgaacatgta tcagtggaag acgtgaatac gattatcaaa gataatgaga 2208361 aggtgctcgt atgacaaaac ggggcattca ggcatttgct ggcggcatca ttttagcgac 2208421 agccgttctt gcagctgttt tttatctgac tgacgaagac caggccgctg ctgtaaaaga 2208481 taataaaaca gtaaccgaac aagacgtgaa caattatctt gattctaaaa aattggtttc 2208541 tgtcaaccgt gatgaatatc aaaaacttct cgattcaaaa gagaaatcct taaacaatga 2208601 cagcggctca gacacgaaat cagacaaagt caaaacctac aagctcacca ttaaagacgg 2208661 catgagcacg gcggatgtat ctgctattct tgaaaaagag ggcattatct cttcggctca 2208721 agactttaat gactatgtca ttgatgccgg ctatcacaaa gaaattcgtg ccggcgagtt 2208781 taaagtaaaa tcagacatga gtttcaaaaa gatcgtaaaa acgttaacac gataaaaaaa 2208841 caggctgact cagcctgttt ttttcatcca aactttcctg aaatgtaatc gagcgttctt 2208901 tggtccttcg ggttagagaa cattttattc gtattgtcgc attcaacaag ctcgcccatg 2208961 tagaaaaagg cggtttgatc agaaaccctt gctgcctgct gcatgttatg cgtgacaatg 2209021 acaattgtat atttatcttt cagctctaga atgagttctt caatttttct cgttgagatt 2209081 ggatctagtg cagatgtcgg ttcatccatc agcaaaatat caggattggt cgcaagtgct 2209141 ctggcgatgc aaagacgctg ctgctggccc cctgacagcg aaagagcgga cgtatgcaat 2209201 cgatccttca cctcatccca taacgccacg tcttttaatg acttttccac aatttcctga 2209261 agcttcttct tatttttggt gccgtggact ctcggtccgt aagccacatt atcaaaaata 2209321 gattgcggaa acggattccc tttttggaat accatgccga tattttttcg caaatccacg 2209381 atgtccactt tatcctttaa aatgttgctg ccattatagt tcagctcacc tgcaagcttt 2209441 acattcggcg tcatttgaat cattaaattc aatgtcttga taaaggtcga tttcccgcat 2209501 ccggatggtc cgataatcgc cgtaacctca ttttcataaa tgctcaaatt gatatttttt 2209561 aaagcatgat gctgcccata ccataagttc attccattga cttgatatac ttcctgtttc 2209621 attacagctt cggtagcaat actcattgcc gccctcctat ccgaatttcc cgttaatata 2209681 atcctctgtc ttttgctttt tcggactcgt gaaaatctgt tcggtctgtc cgtattctac 2209741 aagctcgccg tttaaaaaga atgccgtccg gtcagaaacc cgcagagcct gctgcatatt 2209801 gtgcgtgaca ataataattg agtattctct tttcaatcct gtaattaatt cctctatttt 2209861 tgcatttgaa atcggatcaa gcgctgaagc tggttcatca agcagaagaa cagccggctt 2209921 catcgcaagc gttctcgcga tgcataaacg ctgctgctgg ccgccggata acgagagtgc 2209981 ggatgaatgt aaacgatcct tcacctcatc ccagagcgct gcttttgtta aactttcttc 2210041 cacaatttca tctaaaacag ctttattccg ctctccggca tatttcaatg catgtgtgat 2210101 attcgcatag atcgatttcg gaaatggatt tggtttttgg aaaaccattc cgatttctct 2210161 tctcaagctg acaacgttaa tattgccgcc caatatattt aatccctcat aaaggatttc 2210221 accttccgct cttgcagatg gaattaaatc gttcattcgg ttaatatttc tcaaaaaagt 2210281 agattttccg catcccgacg gcccaattaa agcagtcacc gcattttttt caatatccat 2210341 gtttacatga tgaacggctt gtttatttcc gtaataaatg gacagatctt tgacctcaag 2210401 cacgtggttc tgcttcggaa caataacagc tcgctcaggt ttttctttta ccatttgttc 2210461 agacatgttt ttcgcctctt tccgttctaa tttgccgtaa gctttttgta gatcatcgtg 2210521 ccaagccatc tcgccgcgag attaaacaca agaacagaaa tcaccagcac ggcagaacca 2210581 ccgttggcaa tcgcttcagc atccggaatc attccttgtg tattgacgtt ccaaatgtgg 2210641 accgcaagtg tttcagcggg cctgaaaata ttaagcggtg atgtttccga aaacgggttc 2210701 cactccgtaa aattaagacg cggtgttgtc aggcctgccg taaataataa tgcggccgct 2210761 tccccgaaca cccttcctga cgctaaaatt gctcctgtga tgatagaagg aatcgcactt 2210821 ggaattaaaa ctgtttttac ggtatgccag cgtgatacac ctaaagcgag agaggcttcc 2210881 ttcagatctt tagggactga acggatcgcg tcttctgtca cacgcaccat gacaggaagg 2210941 ttaaaaacag ttaacgcaag cgctccgcct atgatcgtat aaccccagcc tgttaagttg 2211001 acaaacatca ataatccaaa catcccaatg acaatagacg gaagagatga aagcacctct 2211061 atacatgttc taatgaagtc agttactttg ttattaggcg cgtattcagc catgaagact 2211121 ccgccgccca caccgagcgg gattgtaatc agcattgtaa taaacaaaat ataaaaggag 2211181 ttaaacagct gatctcgtat gcctcctcca gctgcaatgg cgctcgactt tgttgtaata 2211241 aattgaaaac tgagctgaga aacaccgttt ataataatat aggaaaacaa acctactaaa 2211301 atggcagcga taatggctgc acacaaacca aacattccgg tcgccagttt atctgttatt 2211361 ttgcggttca ttacactttc ctcctagatg acaagtagcg aataagcagg atgaacaaga 2211421 atgacatcac cagaagcaca agccccattg accacagcgt attgttttca acacttccgt 2211481 atgtggtgtg gcccatattc agcgtgatga tcgttgtcag cgttcccgca gtgtcaaacg 2211541 ggctttccgg caatactctt gtatttccaa tgaccatctg aacagccaaa gcttcaccga 2211601 acgcccgagc catgcctaac acaacagctg tcatcaatgt tggaaaagct gcaggcacaa 2211661 gtacttttct gatcgtctgc catcttgtgg caccaagcgc gtaagaaccc tctcgtaaac 2211721 tcttcggaag agaagccatt gcatcagcag aaatcgatgt gatcgtcggc agaatcatga 2211781 cggaaaggac aatcgttccc gccaataaac tgtgccctgt tccgctcgat ttgaactggg 2211841 cgataaacgg caccaatact gtaagaccta tgaatccata aacaacagat ggaataccga 2211901 ctaaaagctc aatcaccggc tgcagcactt tctttcccca attcggggca atctctgtca 2211961 taaaaatcgc acctgcaatg ccaagcggcg cagcgattag agcagaaaga atcgttactg 2212021 caaatgagcc aaaaataaat ggcagcactc cgtatttcgg atcactatct gtaggattcc 2212081 aatttaagct cgttaagaat tcaattgggc ttacaccatt tacaagaaaa gattgcagcc 2212141 ccttaacgcc gaggaaaatg gtaatcgcaa cagatgccgc aatcataatc agtgcacaag 2212201 ctgtgactat cattcttccc cgaacttcat ccaattgccg attttgccta gagctgatta 2212261 agcgctcgct cacagacata ttttctctat tgtttatcat tgttttacac tcctatgaat 2212321 gtgttaagag gagaaacggt tgtccccgca ctcctctttt tattaagatc agctttgctt 2212381 cccgttggca tcacgtgtca ctttcatatc agtaaccgga atgtagcctt ggtcagtaac 2212441 aatgcttttt tgaatgtctt cactctttag ataatcaaga aattctttag ctaaacctgt 2212501 cgcttcacct tttgtataag aatgttgata agcccagatc ggatactcgc cagttgctac 2212561 atttttcgct tcaggtttaa caccgtcaat agatagagca gttactttgt catctgttaa 2212621 atatgagaat gcaagatatc caatcgctcc cggagtatca gcaatgatct ttttcaccgt 2212681 gttggaggaa tcttcagtaa tgccttctgc aggctccgct ccgtcaagcg catatttcac 2212741 aaatgtagca cgtgtgccgg aagaatcagg gcggtttaca agtgtaatct tttggtcttt 2212801 gccgccgagc tctttccagt ttttgatttt gccagtgaag atttttttca attcatcttt 2212861 tgaaatatcc tttacaccag catcagggtt tacagctgct gccataccaa ctacagcgac 2212921 ttgatgatcg acaagcgctt ttgcatcgat gccttctttt tcttcagcaa aaacgtctga 2212981 attcccgatc tgaacagctc cttcagagac ttgagaaagc cctgttccag aaccgccagc 2213041 ttgtacctgt atatcagcat cagggttttc ttccataaat ttttccgcgg ctgcaagtac 2213101 tagtggctgc attgccgatg aaccagaaat ggttaaagaa cctgatgcct tttcttctcc 2213161 ttttgcagaa tcgctattcg attttttact ttctcctgca tttccgcatg cagctgcaat 2213221 catcataaaa gcagccatca gaagcataag caccaatttg ttttttttca tttcctgaat 2213281 tccccctgcg tataatgtgt aatttgtcct acacgtatag agtaaaggtt ctatgtaaaa 2213341 agggtttgaa ccgaatgtta aggttttgta aatcagtgcg tttttttgta taaaaaaaac 2213401 gcccacatca tgtgagcgtt tttttttagt tatcagaaga cgttgtgttt tctgcatttt 2213461 cttcaatttt gtctttattc ttttgctgag taccttcttt gtcctgcttc gatttcagct 2213521 caaaatattt atccattact tccctgccga tttcgtttgt aattgagtat ctttgattgt 2213581 aatcaatgta agtccaagga actacgacag aaatagcaat ctcaggattg tcagctggtg 2213641 cataagccac aagcgtcgta ttataagtgt ctgttcctgt ttttgattta tccggtccgt 2213701 cgtaaaatga ttgggctgtt cctgtttttg cagctggttt atacgatgct gaagccagtt 2213761 gacctgcagc tgtcccttta gtggcaaccc gtctaaaacc ggcttggacc tcttcaatat 2213821 agctactctt catatcgact ttattcaata cttcaggctg aacagaatca acgactgcgc 2213881 cgatcccttt tttcgcattt gaatctctga cttcctttac aagctgaggc ttcatgcggt 2213941 agccaccatt tgctatggtg gagacatatt gagccaattc cagcggtgta taagtatcat 2214001 actgtccaat ggcgaaatca agcaagaaac cagataatct gcttgtacct ttatatcccg 2214061 tcatttcatt tggtagatca attcctgttt ttactcctaa tccaaattga ctgaaataat 2214121 ttctgaaggt atcaaatgca gaagtatcca aaggcaatgc ttggtgaggt ttatattcac 2214181 ctttaccaac tgcaattgct gttttaaaca taaaaacgtt tgatgacttc tctaatgcag 2214241 tttgaatacc aaccggccct aagttttgcc aagatttttt ccctctttta tcctggccga 2214301 tatacaatgg ttcatcctta aatacagtat tcaaattaat cgctccagtt tgaagaccgg 2214361 tcaaaacggt tgcacctttt acagctgatc ccatagcgta ggatgaagtc atggctccta 2214421 atgcataatc atcaaactta taggctccat tttctcgttt aatctgcttc cctgccattg 2214481 tcagcacttc gccgtttcta gggtccatca tgacaacgaa tgcacgatcc aacaattcgg 2214541 tactaggtct tgctttagca gctttaagtt ttttctcaat aattttttcc actgattttt 2214601 gcaaatcaat atcaattgtt agtacaagat ctttcccggc tttgccttca gataccgttt 2214661 ttgttcccgt gacattgcct tttgaatctg tgatattttc gacttttgct ttttggccct 2214721 gcagaaggct ttcatattgg tattccagat agctttttcc gaccctgtca tttcggctgt 2214781 agccaagcga cagataatgg tcgagcaagt tggacggcaa tccttcatta gagctggaaa 2214841 cacttccgag cactgagcga agaaggtttt tataaggata ttcacgttcc caatcggacg 2214901 tgacatcaac acctggcagt tcgtctaaat gttcacttac cactgccatt tccttcgctg 2214961 atacatcttc gtttttgata tattgagggg tcaatgcata gcccgaatcc atctgtcttt 2215021 tgatagcaag gatctgcata tctttatccg tcaattcatt cagctgctta tcagtaatcc 2215081 gttttagctg aagctggtat aaatcgtcat cggatatttt tttgtcttca acctgctgtc 2215141 tttctttaga gctaatgagc tttttcgctt ctttcggtct agtcaaaatc caataatctt 2215201 ttttatcccg ttctgttact ttttttgtat cgactttgat catgtcagac agcttttttg 2215261 cgatctttaa gcgctgttct tgcgtggtcg atttagatct cgtgtatgtg attgcattta 2215321 aagccttatt tgtcacaatg gcattaaagt ttcgatcata aattttcccg cgtggtaccg 2215381 ctgagctgac ttcactttgt tcctgcttat tcgcttggtt tttgtaatca tcaccttgca 2215441 cgatctgctt gatgcccagt tccacaataa tccaggtaaa tataacaaag gcagctaaaa 2215501 ataaaatatt cagccggatc ggaagcgact tctttttctc tttatgattt tgcttttttg 2215561 gtttatttct cctcataaca tcaccttttc tatttacaga aagaaaagac actcaagtaa 2215621 gagtgccagt tttcatttta aaggtttttt cgactttttt ctacagataa cccctttttg 2215681 gcaaaaaaat tatctctcgc cttttaaaag ggtcggttct gttacccgtt tttggccgtc 2215741 ttcttccatg gtttcatttt ccccttcttt ctccttaaaa cgaatatcct tgacaaagta 2215801 ataaatcaaa ggatgtccta tacccaatat cgcaagtgac aaaggaattc ccacatcctc 2215861 tttcagaagg gccacaatca ggagaaagca caaaatggaa acaattctgc cggcgttcaa 2215921 gaacatttct ctaagcacga tatattcaat tcttgctttt ctggcatgcc tcgcgcgccc 2215981 tatcacatca tatgtaagtg atacatatgg cacaagcaac agaggatagc cgatggcaat 2216041 aaaaacgccg tacgttaata atgtcgaaaa gctcatatgg aacagaatca aaaacagcgc 2216101 gccatacaaa ataagtccgc ccagcaaaat cgattttttt ctcgcctttt tcttaatcag 2216161 cctggatgca aagtagtagg caaagaagga aacagctgaa ttgacaagac cgaatgtacc 2216221 gagagcaagc tcgctgtttg tctcaataaa tacaaacaca ctgattaaaa agacaaaaat 2216281 cccttctctc aaaccctgaa aaaaatgcgc attcgtgatt ctccgccaat tcatattgct 2216341 atggcgctct ccaaatactt tgctcagcat aaaacggccc tttgattctc tccgttttaa 2216401 gaaaaagctc atcacgacag ccagggcaaa taaactgagg gagagactga aaatcactgt 2216461 ataacccgta ttattttcaa gccttgagat cacgaatccg gctacaatcg ggccgatcat 2216521 tcctgcagag gaagacagaa tgcccataaa cccgttgaaa aagtctcgtg tatccggctc 2216581 tgttatttca aaggtcagca cgttaaacgc tagccaataa aagccatagc caactccgag 2216641 caccgcgccg attagcacga ggcggctggc cgccgtttct ccggctaaaa gcacacttaa 2216701 ataaaaggca gctaaaaaaa tgacgccgaa ccttaaaatg aataccctgt ctattttttt 2216761 ggctaaccgt ccagccaaat aaaaggttat cggctgcatt gtcacaatgg ataaattata 2216821 tatcgccaaa tcaataaatt tccctgactg cttccaaaga tacacattaa caaatgtatt 2216881 ggacagtgca attcccagcg agtaaagccc gccaatggtc agcagaaaga gtaagccttt 2216941 gtttacgtct acatcgccta tcactttttt tagtttgctc attactgact cccctttact 2217001 atcccttagt ctgtctcact caaaccgaga tatgtaaaaa gaagacataa aaaaacaagg 2217061 tcccataatg aggaccttgt ttgtgccatt attttgcttc gctgtataga cgagccactt 2217121 cgtcccagtt tacaacattc cagaaagctg aaatgtaatc aggacggcgg ttttgatagt 2217181 taaggtagta agcatgctcc caaacgtcaa gacctaagat aggcgttttg ccttctgaaa 2217241 gcggagaatc ttggtttggc gtgcttgtga tttcaagttt accgttgttc acaacaagcc 2217301 atgcccagcc agaaccgaag cgtccagctg ctgctgctgc gaattgctct ttgaatttgt 2217361 caaagcttcc aaatacactg ttaatctctt cagcaagcgc gccagtcggt tcgcctccgc 2217421 cgtttggaga taaaagtgtc cagaataatt tgtggttcgc gtgtccgccg ccgttgttgc 2217481 ggactgcagt gcggatgttt tcaggaacag aatcaagatc tgcaacaagc tcttcaactg 2217541 atttgttggc aagagcagtg tttccttcaa ccgctttgtt taaatttgtc acgtatgtgt 2217601 tgtggtgttt cgtatggtga atagtcatag tttccttgtc gatatgcggt tctaaagcat 2217661 cgtacgcata aggtaattct ggaagttcgt aagccatgat aattcctcct tagtatatat 2217721 gtactgaaat gccgcttcac agcgagcctt tcttcattca atgtaacaaa agaatgcttt 2217781 gtaatcaatg aaaaagctca cgatttggct catttcagcg gacatatttc actttaaccg 2217841 ataatctgcc ccattaaacc tgccgccagc atttcttata ggaccgtcca taaaaagtaa 2217901 ccgatcatca aaagctgtat gatgcccttt gcaataaccc ctgttaaaaa accaatgagt 2217961 gagccgaggc caattttaaa cgctgacttt aagtccttct gatggacgat aagttctgcg 2218021 caaacagccc cgataaacgg ccccaatatg atccctgcaa ccggaatgac aaaaggcccg 2218081 attaataaac cgatcgtgct tccccatatg gcagctttgc ttcctccgaa cctttttact 2218141 ccaagcagat tcgacacgta atctgctgcg aataatactg cggcaaaaac tgcctcaaca 2218201 agccagaaca tataagaata cggactgaat gaaaataaaa atccgtacaa tacaaatccg 2218261 gcaacaataa atactacgct aggaataaca ggatacacca gcccgataaa ggcaatgata 2218321 aaaaccgctg caatcaacag ccaatacaac atatccatag cttccatcct cccattttac 2218381 tctgtcttct tcatgtcttc cttgtattca cacgcatgca acgatacaat aagcaacata 2218441 tattagttta gctaggaagt gaagatagtg aatgtgtttc agcttttcat taaaagtaca 2218501 tactctcccc gtgatattgc aaaaacaaga tttcaaggaa tcggaaaagc gattctttat 2218561 gtatttttgc tctctgtcct gtttgcaatc cctaccgctt attatgtaag tacagggacc 2218621 gtaaaatcaa tgaacggctt taaaactgtt ttaaacaaag atttccctga tttcacaatt 2218681 tcaaacggca aacttcaaac ggatgagaaa aaagccacgg aatctcaggc aaatggtttc 2218741 gttatcgtgt tcgatccgac agactcctat ggcactgaac aaattgaagc aaagcaaaac 2218801 gcaatcggca tccttcagaa caaatttgtt ttggccattg acggacaagc ccaagaaatg 2218861 tcttactcaa tgatgccgtc agagttacag aaaaaagatg tcattgcagg tttaaaccaa 2218921 aataaagcga tgattgtaac tgttctctca gctcttattt ttctcgtaac agcagcggga 2218981 aaatttattg aagtatcgtt tttagcgctt atcgggttaa tcattaagaa ttcgcagaaa 2219041 aaacatttat cctatcatca gctctggaag ctttctgctt attccatcac actttcaact 2219101 gtattcttta caatcatgcg ggcactagaa gcaaccgtac caagtgaatt tttgctgaac 2219161 tggtttgtca attttgtcat cctgtttctc gttttaaaag agattccgtc caaaaaagta 2219221 attaataaaa gttaaattat atttattttt atcctttaag tagagagtgt gaaagcattt 2219281 gcattaactt tttacttaag ggatatttaa taaaatgtat agagcttaaa cagatacatt 2219341 tataaaaaaa gctctacaat tactcaagaa caagctctgg acaataatat cagaagtagt 2219401 aagatgtaac atgaaagaag ttcttaacag catttgacat atgtttttaa caaaataaga 2219461 ataatgttaa attttaacta atagactagt taaaatcata tggcaaaata ttttgcatcc 2219521 tttcacaaca tatttacata agatagttgc tatttaaaaa gccaggtacc aatagggcac 2219581 ctagctttca gaattaaatc atcaacaagt tagaattatc ttctttcctt ctattctcat 2219641 tattgaactg ttatcttttt tgtgggttta tgtatacaaa tgcagctccc ttagctttcc 2219701 ccttatatac tgataaacct actgcccaag gtgttcctgt cggttttggt aatttactga 2219761 agtaaaactt tttggttgga gttctacttg aaaagtaccc tgaatattgc gggccaatgt 2219821 ccccaccctc aactatagat acaccaaagc tcttataatt tagtttaccg cattttccat 2219881 ttgtttcggc gtaagcatca atagatgttg cactcttagt atatgtataa gcatctgtaa 2219941 taactcttat tttacaacca gaaataccac ttaccggttg ccaaccactg cttgcagcct 2220001 ctgctttttc tttaggtgca actaccaaag ttaacattag tagcaaaatt aaaaacacag 2220061 aaaattttcc ttgcttcatt ttgtagatcc tcctttaaac tattacataa ttatcctaac 2220121 agatccattg ttcattgtaa ataatggaat acgagtttta tattataaaa gcctcttttt 2220181 gatctaattt tgcactattt tctattttct atctgaagtt aatgtttagt cgaagaaatc 2220241 ctgtcaaaaa agcgcctgta taaaaaccga gcattcgcag tctcttttct tttgtcatga 2220301 atcgaaatgg acaagcatac tatggtataa aatttcgtat gcgggaggaa aagcgatgaa 2220361 gcgtctcacc ttagtatgca gcattgtttt tatacttttt attctttttt atgaccttaa 2220421 aattggaacc atacccattc aggacctccc tgtctatgaa gcatcagcaa aaacggctgt 2220481 acaagaaccg gcttataaaa cggtgaaggt aaagccgggt gatacggtta tgtcgatagt 2220541 cggatcagca ggttctccgg atgacattgt aaaggatttt gaagcactga atccaaatgt 2220601 gaaagctaac gccattcaag ccggaacagc gtataaattc ccggtctacc cttaatttaa 2220661 cgttaatttc ttgtcagttc ggcgaagaca ctgttacaat gtaatttgta aaataaattc 2220721 acataaacca tactagaatt gttatatcta gaagcggcaa ctacaattaa ggagcgattg 2220781 caagtgagtg aaatcacaca tcgtacaaaa acgcgtcccg tcaaagtggg acctttaaca 2220841 ataggcggca acaatgaagt tgtcatccaa agcatgacaa caacaaaaac acatgatgta 2220901 gaagcaacgg ttgcggaaat taaccgtttg gctgaagccg gatgccaaat cgttcgggta 2220961 gcatgtccgg atgaacgggc ggcaaacgcc attgcggata ttaaaaagcg catttccatt 2221021 cctctcgttg ttgacataca tttcgattat aaacttgcgt tgaaagccat tgaaggcggc 2221081 gcagataaaa tccgaatcaa ccccggcaat atcggccggc gcgaaaaagt tgaagcggtt 2221141 gttaaagcgg ccaaagacaa aggcattccg atcagaatcg gagtaaacgc cggttcattg 2221201 gaaaaacgga ttttagaaaa atacggttat ccgactgccg atggaatggt agaaagcgca 2221261 cttcatcaca ttaaaattct tgaggatctt gattttcacg atattattgt cagcatgaag 2221321 gcctctgacg tgaaccttgc aatcgaggct tatgaaaaag cagcgaaagc gtttgactac 2221381 ccgcttcacc tcgggatcac cgagtcagga acactgtttg ccggcacagt aaagagcgca 2221441 gcaggactcg gcgccatttt aagcaaaggc atcgggaaca ccatgcgcat ttcactaagc 2221501 gcagaccctg tagaagaggt aaaagtagca agggagcttc tgaaatcttt cggcttagcc 2221561 tccaatgctg ccacgctcat ctcatgcccg acttgcggcc gtattgagat tgatctaatc 2221621 agcattgcca atgaagtgga agagtatatt tctaagataa aagcgccgat taaagttgct 2221681 gttctcggct gcgctgtaaa cggacctggt gaagcgagag aagctgatat cggaatcgcc 2221741 ggcgcacgcg gtgaagggct gctgttccgg aaagggaaaa ttgtccgtaa ggttccagag 2221801 gaaacgatgg tagaagaact caaaaaagaa attgacattc ttgctgagga acactacgca 2221861 aaacttgaag ctgaaaaagc aaaattaaaa gaagaaacac aaaaagcttg acgggaaccc 2221921 gtcaagcttt tttgtgttag aaaaatggaa taataaatat tccaagcact aatgaaacga 2221981 caccgatacc cattgcccag gctccaaggc cttgagcacc tcttcttctt gcgatatagc 2222041 cgacaataat accagcagct cccaataaaa caggcagtac aaacaatgaa atgatggaca 2222101 aggctaaagc gatgtaccct attccccgtc cttcattgac attgccgccg ctgcgatcat 2222161 tgtcttggtc attgctgcgg tcagcagcac gataaggctc tgcgatttca gcagctgttt 2222221 cctcaaaaaa accgtcattg tcgcgggtaa tatttgtccc ttcagatcca tgatcaacat 2222281 agtaactgtt gttatcacgc ttttcgtaat cgtttgccac cttcaattcc cccttctgtt 2222341 ttattaaagg agcttttata gtttgatcca ttttgcctga ttcatgtttg ctaaactttt 2222401 ctgttaatgt caattgttta tgttacactt gaagggatga aactgaagga gtgtgggcat 2222461 gttacgctta ggaatagata ttgacggcac aatcacggct caggatacat tcgtccctta 2222521 tttgaaccgt tcgtttaatc tttccatttc attaaacgat atgacggatt atgatttaac 2222581 aaagctgtta aacattaccc aggaagaatt ttgggattgg atgaatcaaa atgaagcgat 2222641 catatataag gaagcattgc ttgcacagca tgcgaaacag tctctcgatc ttctcaaaga 2222701 ggagcacaag cttatttata ttacagcgag acggactcat ttaactgata ttacttatga 2222761 atggtttgac agacaaaaca ttcattatga ccacatcgaa cttgttgggg gtcatcacaa 2222821 agttgaagcg gtcaagaatc ataacatcga cctgtttttt gaggatcatc acgggaacgc 2222881 catgatgatt gcgaaagaag ccgggatacc ggtgattttg ttcaattccc cttataatca 2222941 gcttccgatt gattcaaaca tcatcagagt aaacaactgg ctagaagccg ttcaatggat 2223001 gaacaacaac aagcatcact taatacgcgt caataactga aaaaggagcc caaaccgggc 2223061 ccctttttca tatatacgca ttttacgcag tagtgttttc ttggttttcc gctgtacaat 2223121 cagggcatgt gccataaatc tcaaatttat gcccgctgac ctgatagcca tccaaatcat 2223181 cacaaagctt gtccatcgga catgattcaa tttcctttgt tttgccgcag gcaagacaaa 2223241 taaaatgatg gtggtgatgg gtgaatgaac acttaaatcg gaagagcttt tcaccggaca 2223301 gctcagttgt ttccaaaatc ccaagttctt catataaaga aagatttctg tagattgtat 2223361 caaagcttaa gcctggataa tcatcattca gtgcagacag tacgttttta gcggtaagat 2223421 atctgtctga atcagcaaaa agctgcagca tatcctcccg tttgtttgta tatttatatc 2223481 cgttttcttt taataggttc agcgcttctt ggacgttcat gaagggtccc ccttttcgct 2223541 ttgcttaaga acgtatcaca tgtatgaaaa agaaaatggc agctgtctgt ccagcaagcc 2223601 attttcttta ctgcagataa aattataccc ataaaatgaa taaaagtaaa tgaaagccta 2223661 gtggattgcg tttttgaatt ttccgcctct cgtttcatga gtattcataa ttgttatgaa 2223721 tgcattttga tcaacttcaa acacgatcga tttgagcttt gtcacttcca gccttgtgac 2223781 aaccgcgtaa attacgtctt tttcttcgtc cgtatacccg cctttcccct tcagcttcgt 2223841 tgtgccccga ccgagacggt gcaaaatcgc gtcggaaatc tcatcatact gctcagacac 2223901 aataatgaca gcttttgttt catcaagccc ttggatcacg gcatcaatcg ttttcatcgc 2223961 aatataataa gtcatgaatg agtacatcgc ttgctcagga ccgaacacaa aaactgccca 2224021 aatgaaaatg aacacattga tgaacataac gaactcacct acagaaaacg ggagtttttt 2224081 ggtcagcaaa ataccgagaa tttctgtacc atccattgaa cctccatttc gaataacaag 2224141 cccgacgcca aagccgagta aaagacctcc gaacacagta gccaaaatag gctgggttgt 2224201 aatggcttct acatggtgaa gtgaggattc aataacggca agcccgacaa tccctataaa 2224261 cgtagagact agaaaggtct taccgatata tttatatccg aagatcataa aaggaatatt 2224321 taatatgaca acgaaaaaag cgaaattcag aaaggggttt gacataaaga ggtggtctaa 2224381 aataagagat acaccgataa tcccgccatc aataaaatca ttggggatta aaaataattc 2224441 aatacttaca gccgcagatg cagctcctac cagaatcata aagaccctga aaataaaatg 2224501 ggtaaatgtt tctttcttat gttgttttgt tggggtcata aaatctcctt tcctgcaata 2224561 actattttaa atacattata aatctatttt accattaaac actgacacat tttactgatt 2224621 tgcccataca ttaagtctgg aggtggaatg accgatgatt ttatttcaaa gaattatttt 2224681 gcagcggctt aatcaggcta ctgctgatga tttgctgaag tactcaaaac aatacggaat 2224741 cagcttaaca agatcgcagg ccgttgaagt agcgaacctg ttatacggga aaaatgtaaa 2224801 catctttaat gagagtgaac gaatgcggct gctgaaacaa gtagagacga ttacatcgaa 2224861 agaaacagct caaacagtta atgaactatt caaacaattt acaagctaaa aaatgggggt 2224921 gttatccccc attttttatt gctgtaaaat cttttcaagc aatgtatcat caaattgttt 2224981 ttctttcagc atttcaatct caaaacggta tggcggtttt ttgttctttt tatcttcacc 2225041 gacgtatggt gtttcaagaa tttttggaat gtcttttaac tgctcatggt gaacaacata 2225101 ttgcagtgcg tcaaaaccta tttcaccaaa gccaatattt tcatggcggt cttttctcgc 2225161 acctttgaca tttttgctgt cattgatatg aagcacttta atacggtcaa tgccaatgat 2225221 tttatcgaac tcatttagca ctccgtcaaa gtcttcgaca atgttatacc cggcatcatg 2225281 tgtatggcac gtgtcaaagc acactgacag ctgctcattg tgtgtaacgc cttcgataat 2225341 ctgcgcaagc tcctcaaagc ttctgccgca ttctgatcct tttccagcca ttgtttctaa 2225401 tgcaatctgg acattttgat tcggatcaat cacttcattt aagccttcaa taattttttt 2225461 gatgccggct tcagctcctg cccctacgtg agcgccagga tgaaggacaa tttgcttcgc 2225521 tccgatggcc gctgtccgtt caatttctga acgaagaaaa tcaacaccca gctcaaaagt 2225581 ggacggattt gtcgtgttgc caatattaat aatataaggc gcgtgtacga taatctcgtc 2225641 aatgccgttt tcttgcatat gtgcccggcc tgcttctata tttaagtctt caattttctt 2225701 tcggcgcgta ttttgcggtg cgcctgtata gatcataaac gtattcgccc cataagagac 2225761 tgcttcctgg cttgcagcca gaagcatatg ttttccgctc atagagacgt gtgagcctat 2225821 tctcagcaac aggttcccct actttctttt cttagattgg tttcttctct gttttttctt 2225881 gattttctcc atctcatagc tcattttctt tttataccca ggcttaacct tcttcggctt 2225941 tttcacgaga cgatgagcaa tttcatccgc ttcattcggc gtttttttac gttttttgcg 2226001 gcgctgacgg tcatcgcctt ttttccattc gcccttttca agctctaagt actcaaattc 2226061 gatgcccatt ttttcaagtc ttactaatgc atcctcatca gtaagctcat aaatggtcat 2226121 cgcttgtcct gatgagccgg cacgagccgt tctgcccaca cggtgaacat agaaatcgag 2226181 atcatccggc agctcatagt tgataacatg gctgacacct ttaatatcaa tacctcttgc 2226241 ggcaaggtca gttgcaatga tatatgtgaa ttccaaatca ttgatctgct tcatgacttt 2226301 tttccgctca cgtggtgtta atccgccgtg cagcaagccg attttcatgc ctttgccagt 2226361 cagatactgg gcaatatggt cagccgtatt tttcgtgttg gcaaacacaa tccccaggta 2226421 tggattcaga tgcgacatga tgtcaaaaag gagcttgtcc ttgtcacgat gtttcgaagg 2226481 aatgaggata tgctcgattt tcgcagcagt cacctgtttt ggctccacat gggcgtattt 2226541 cggattttcc atgtatttct tcaagaatgg tttcagcttt tccggtatgg tcgctgagaa 2226601 cacaagcatt tgcagatcct caggcatgcg ggaaccgatg taatctacat ctgcaaggaa 2226661 tcccatgtcc agcattaaat ccgcttcatc aataacaaga gattccgctt tatgaacact 2226721 taacgcctgt tctttgatta agtcagcaat ccgtccaggt gtaccgacaa caagatgcgg 2226781 ctgtattttc aatttatcaa ttgatttttg tttatcagtg cctccgataa aacatttcga 2226841 gcgaatctga cttccttctt caccctgcgt gattttaagc gcttcctgat aaatctggtt 2226901 ggcaagctct cttgtcggag ccgtaatgac tacctgaacg acatccttag caggatcgat 2226961 tttgtttaat aaaggcagta aataagcgtg agtctttcca gtacccgtct gagactggcc 2227021 gatgacgctt tcttttttta acactgcagg aatcagcctt ttctggatat cagtcggttc 2227081 gtaaaaacca aggcgatgta ctgcatctat aataaatggt ttcaattcat aaagttcaaa 2227141 tttcgtttct ttcatttttc ccagctcctt aaagcggcac attatgtgtc catcatcaca 2227201 ttatacccga ttttgcttaa aaacaccacg tttgcaaggc gtttgtttta ttcagttatg 2227261 taaagcaaat accgcagccc atgcatattc taatagcaga gagagctgaa aggaggtaca 2227321 agtatgtttt caccgcagca gccaatgaga aattacccac agcccggacc gccccgcccc 2227381 atgccaaatc agcgaatgat gggcagaaga ccgcctaata tgcgaggacc ttcatttgga 2227441 gcacagcagc aaggttttca gcaagccgga caatttcttc ctcaggcaaa tgccggagcg 2227501 agaaatggtg caggtgcagg cggaggctta aaaggaatgc tgtcaaggtt cctccccggc 2227561 ggaggaggcg ctggcagcgc cggggttccc ggaattccag gagcaggtgc agcagcgagc 2227621 ggaggtgctg gcctgcaagg cattcaaaat attgccaatc ctgcatcatt atccagtatg 2227681 cttggaaatg tgcaaaaagt actcggcatg gcgcagcaag tcacccctat gatccagcag 2227741 tacggcccat tagtccgcaa tctgccagca atgatgaagc tgtacagcca attaagtaaa 2227801 agtgatgata ctgagacaga ggccaatgag gaaagtgaaa aacaatccgt ttcagaagaa 2227861 tcatcagaaa aagaaaaaga gactgaaaca aaaacctcag atgggaacaa aaaatcaaaa 2227921 ccaaaaagtt cttctctccc aaagaaatct aaaacaactg acaataaaga acaagaatta 2227981 aaaacatctg ccccgaagaa aaaggaagct gcctctcctg ctccgaaaag aacatcaggc 2228041 agttcaaaac cgagattata tatttaacat tctttgatat cttaagtgag attggctata 2228101 atgagatcag aagaatgcaa gaatagagcc gtttgattac ggctttttat attgccttta 2228161 ctcacttcag tattggagga caaccgaaaa tggacgtaat taaaatttca ccgcgcggct 2228221 attgctatgg tgttgttgat gctatggtca ttgccaaaaa tgcgtcgcta gataaaagct 2228281 tgccaagacc catctatata ctcgggatga ttgttcataa taaacacgtc actgatgcgt 2228341 ttgaagagga agggattttt acattggacg gctctaaccg tctggacatc ttaaagcagg 2228401 ttgacaaagg aactgtcatt ttcactgcgc acggtgtttc tcccgaagtc agaagaatcg 2228461 cagaagaaaa agggttagtc gcaattgatg ctacatgtcc ggatgtgaca aaaactcata 2228521 atctaatctt agagatgaaa gaaaaaggat atcacgtgat ctatatcggc aaaaaagggc 2228581 atccagagcc tgagggagcc gttggcgtag cgccggagat cgttcactta gttgaaacag 2228641 aagaagatgt aaagaacctt gatatccaat ctgagaagtt aatcgtgacg aatcaaacaa 2228701 caatgtctca atgggatgtt cacgacatta tggagcttgt caaagaaaaa tatcctcatg 2228761 tcgaatatca ccaagagatt tgcctcgcta ctcaagtgcg gcaggaagct gtatcagagc 2228821 aggcaaaaaa agcggactta acaatcgttg tcggagaccc gaaaagcaac aattcaaata 2228881 ggcttgctca agtgtcagag gaaatagccg ggacaaaagc ataccggatc ggcgacttaa 2228941 gcgaattgaa gctcgaatgg ctgaaaggcg ttaataccgt tgcagttaca gcgggagctt 2229001 caacaccgac gccgatcaca aaagaagtca ttcgcttttt agagcagttt gatcacgaag 2229061 atccatcaac ttggacaact gaacataata taccgctcaa aaaaatactt ccaaaagtaa 2229121 aagcaaaaaa ctgaggctgt aaaagcctca gtttttttat agaaatgtaa atggatttgt 2229181 atctgtttca gaaacaaaga tattcacgcc aaacttttta tcattacaca ttgatgtaag 2229241 ttttctcgtg acgccttctt tcatgatttt ttccgcgtaa tggcccggat caaccacatt 2229301 taggccaagc atcatcgcat catgggccac atggaagtat aaatctcctg tgacgtaaac 2229361 atcggctccc tttcgttttg catgatgaat atacttgttt ccatctccgc caagaacagc 2229421 tacttttttc accatgctgt cagcatcccc aaccattctg acaccattga cgtcaagctt 2229481 gtctttcaca aataaagcga attccttgag cgtcatctca tttttaaggg ttccgacacg 2229541 gccgagccct ttttcggcgg gagtctgttc gacaggatag atatcgtaag cgacttcttc 2229601 atatggatgg ctttttatca ttgcattgat aacagccttt tcgacgcttt taggaaatac 2229661 agtctcaagc cttacttcat gaacaagctc aagctctccc acttcaccga taaaaggctt 2229721 agctccgtcc aatggcttaa agctgccgat tccttcagat gaaaacgcgc aatggctgta 2229781 ttcaccgata tggccggccc ccgcatttcc gagcgcggct ctgacctgct cttcatattc 2229841 cttcggcacg taaactgcca gctttttcag aggatccgta taagtaggtg ccagcacttc 2229901 cgtctcactc agctctaatg cttcagcaag caaatcattc acaccgccgt ccgcaacgtc 2229961 taaatttgta tgagctgcat aaacagcaat atcatgcttc aaacactttt caattaacct 2230021 tccggcaggc tgatctgttg aaatatgctt tagcgaccgg aaaattggtg gatggtgtgc 2230081 aataatcaag tcaacctctt tttcaatcgc ttcatcgata acgctctcta acacatcaag 2230141 tgtaaccatc acatttttaa ttggtttgtt taaggtgccg atttgcaggc cgattttatc 2230201 tccttcaacc gcataggctt tcggggaaaa ttgttcaaac agctggatga tctgctgccc 2230261 atttacactt ttagccatga tcgattacct cctttaacag ctccattcga tcggcgagct 2230321 cctttaattt ttgtttgttt tgctctgtat ccgccgcttg gctgatctgt tcataaatgc 2230381 tttgagtgtg ctgaagctct tgtgtccact ttttcaaaaa gacagcattt ttttcttttg 2230441 ccaagaaagg gccaacgagc atcccggctg ataaagaaat accgtcataa gccgcatccc 2230501 tgtctcccgc ttctgccacc agcacctcat agcactttcc gtcctcttca aggattacct 2230561 catctatcag cgcatatctt tctttataaa gccactccct gatatgaaca gcatgaatat 2230621 tcggctgtaa aatgagccgt tccttccccg ttaatttgtc tttgcccgct tctaaaatgt 2230681 gagcgatcaa agccccgccc attccggcaa tcgtaatggc atcagcttca ccttttttaa 2230741 tcacttccag tccgtctccc tgccttacag aaatgtgcga gtttaagcct gatttttcaa 2230801 cctgccgctt tgcagacaaa aatgggccgt ctgttatttc tccggcaatc gccccgctgg 2230861 ctttatgatt cagcaccgca taacaaggaa ggtaggcgtg gtcagagccg atatcggcca 2230921 tcaccgctcc attcggtatg tactccgcta ctgtttgcaa tcgtttagat aattttaatt 2230981 cgttcacttg tcatcacaac ttttctcaat cattttttcc tttactatca tataaaaaat 2231041 cagcccggaa tccaagctga agcaaatgat tttgaaatta tttcttttga tgcgggtctg 2231101 cacgcagcag tcaaaaataa aaggctgtcg agaacatctc ggcggcctgt gaatgtataa 2231161 agagaaaaat agttctttta tttaattttt gacacccact ctgccatatc atccagctta 2231221 tcggccggaa caagaccgga aggcattcca ttaccgcctt tttcgatctt tgttttaatt 2231281 tcagcgacat ctttcttatc ccctacacct tttaagctag gacccgaaac accttcataa 2231341 ttttcaccgt ggcatgcgat gcagtttgcc ttgtaaattt cttctggtga agcgtttgca 2231401 tctttctttt cagcagattt gctttctcct ccgctcgcaa tctcccgaga gtcatcaagt 2231461 ccttttactg ataaaaagaa agttagacca attcctaaaa cagcgatcag caaaaatgga 2231521 ataagcgggt tccatttcat ttcccttccc cctttttgat ccttccccct atgtaaacac 2231581 ttctaattct aacttatttt tacaaaaagt aaatggattg ctatacaaaa gttttttatt 2231641 cacactttat acaaaattga atagaaacat gcctaaatct ctaatatcct ttttattcta 2231701 ttgtataatg tattgtatac gcttacaata gaaaatatgg aattagattt tgaaattttt 2231761 caccacaatg ttcatttgca aatgacatca tttttcagta aaataaaggc atattatcca 2231821 tatatctttt taaaaaaaga agaacggatc ttcaagaccc gttccatctt attcaaggaa 2231881 atctttcaaa cgtttacttc tgctaggatg tcttagtttc cgcaacgctt tggcttcgat 2231941 ttgtcgaata cgctctctcg ttactccaaa tactttgccg acctcttcta atgttcttgt 2232001 acggccgtca tcaagaccga atcgaagacg caatacattt tcttcacgat cagttaacgt 2232061 atcaagcaca tcttccagct gctctttcaa tagctcgtat gcggcgtggt cagaaggtga 2232121 agttgcttct tggtcttcaa tgaaatcacc aaggtgcgag tcatcctctt caccgatcgg 2232181 tgtttccaga gataccggct cttgagcaat ctttaagatt tcgcgtactt tttcaggcgt 2232241 taaatccata tcttccgcaa tttcttcagg tgttggttct ctgcctaagt cttgcagtaa 2232301 ttgacgctgc acacggatta atttattaat ggtttcaacc atatgaacgg gaatccggat 2232361 cgttctcgcc tgatcggcaa tggcgcgtgt aatcgcctgt ctgatccacc acgtagcata 2232421 cgtactgaat ttataacctt tgcgataatc aaatttttca acggctttca tcaggcccat 2232481 gtttccttcc tggatcagat caaggaacag cataccgcgt ccgacatacc gttttgcgat 2232541 actgacaaca agccgcaggt tcgcttcagc caatctgcgt ttagattctt cgtcaccttc 2232601 ttcaatcttt tgagcgtagg cgatttcttc ttttgcagaa agaaggttaa cccgaccgat 2232661 ttcctttaaa tacatacgaa ctgggtcatt gattttaacg ccaggcggta cacttaggtc 2232721 attaaggtca aattcttctt cggctttggc aagctgctga atattaggat cttctgtttc 2232781 ttcattctca ctaattaatt caacaccttg ttcacctaaa aattcataat actcatccat 2232841 ttggtctgat tcaatttcaa agctggacat acgctcagca atttcttcat atgtcaaaac 2232901 gccacgtttt ttaccagact ctgttaattg ctcttttact tggtcgaatg ttaattctgt 2232961 ctcgtgggtt tgtttatcag ccattatgga tccctccttc caaagcttgc aacgaattct 2233021 ataagcggta tgattcttat tcggtccatt caggcgtttt ctatgtgaac tgcctttaac 2233081 aatgtgcgaa taatgaaatg acaattcatg atgaggttaa gcgatctatt tgctcctccg 2233141 caaggaatca ttgccaataa atgctcctca tcagttctcc agttatttta aagatcggtt 2233201 caatgtaacg atttcttgag ccaaagaagc agctcttaaa aaatcttttt gcctttctgc 2233261 ttcggctctt tccgcctctt tttcttttat cattgaccaa tttctttgat tcaacacttt 2233321 ttttacataa tctgataact cggcttcgct aagctcttga ttaacctgaa gcattaatat 2233381 atcggacaag agctggctta tatgatcatc cgtcaccctg gccatcagat gctgaggcgt 2233441 cagctcggct ccctcttcat aaaaagcata aagataagcg gctaatgccc ggtgctcatc 2233501 aatattaaat tgaaacccta cccggtcaat cacttttttg atgacgctcc gatctcgaag 2233561 catgtgagcg agtaacagcc tttctgcatt ttcatacgcc ggacgcaaac gtttttgcct 2233621 tgcttttgtc gtcagatgcg ctcgccgcgt tttagtttca ccgctattgt cagcaggttt 2233681 gttttgcttg ctgaaaacag acagctgctc agttaaagac tcctgtgaaa gcgaaaactc 2233741 tgaagcaagc tgctttacat agacttcctg ctctagagac cctgaaagcg tgctgatttc 2233801 tttcagtacg tctttaatgt aagctaggcg gtcgccttca tcggacaggt tctttccttt 2233861 tcggaaatat tgcattttga acgccattac ggtgacactt gcgtcaataa tgtcgttttt 2233921 aaatttttcc ccgccgaatt ttttgatgta atcatcaggg tccaatccgt caggaatcat 2233981 tgcaactctg actttgcagc cttttttttg cagaagctcc gaagctttta aggtggcttc 2234041 ataaccggct ttatcagagt catagcaaag aatgatttct tcgacgtttc ttctcaggat 2234101 cttgacatga tcatctgtaa gagacgttcc catcgtggct atgctttcct ttacatccga 2234161 gcttacggcc gatatgacat cagcaaaccc ttcaaataag actgctcttt cctgctttct 2234221 gatatgaagg cgggccttat aaaaattgta aagcagtttg cttttatgaa agagcggggt 2234281 ttcaggactg ttcatatact taggctgctg gctgccaaga gccctgcctg agaaagcaac 2234341 aacagccccg tgatgatcat ggatcggaaa catgacacgg tttctgaagc ggtcgaaata 2234401 tccgcttccg tcttcgcgtc tgatcaggag acccgctttt tccatttgcg cctcactaaa 2234461 tcccctcttt acaaggaatt tcgtgataaa gtcccaagaa tcaagagcat agccaatctg 2234521 aaattcatta atcagctctt tcgtaaagcc cctagaaagc agataatcca gtgcctcttg 2234581 accttctttt gtatttatta acaaatgatg gtaaaatttc ttcaggagct catgtgcctc 2234641 agccattttt tgttctccag aagactctgg ccgggctccg gaatggactg ttatatcatc 2234701 tggaaaatca atttggtatt tgtcagcaag gtgagaaacc gactcggcaa aagaatagcc 2234761 ttccatctgc cttaaaaaag agaaaacatt gccgcccgct ccgcagccaa agcaatgaaa 2234821 aatctgtttg tcgggcgata cggaaaacga aggtgtgctt tctccatgaa aaggacagag 2234881 tccaaagtag tttcggcctt gcttctttaa ttgaacataa tcacctatga cttcaacgat 2234941 atctgccgac ttttgcacct gatccacaat ttcatctggt atccgatttc ccatcttata 2235001 acactccgtc gtacattatt cgatgcttta gtgcaaaatc ccttcatcgt tcgacaggat 2235061 tttttgcagc agtgtaataa atcgttctcg atcttcttta ttcaattttt taggcccttt 2235121 ggcatatacg ccttttcttc tttgtttgcc ggaaaaatga cggccctcta gggcaaaatc 2235181 aatcgtgtct tccttgtaaa gacgacctct ttccgacata acagagacat ttctgttcaa 2235241 cagcagagat gctaatccga tgtcctgcgt cacaacaata tctcccggtt tcacgtgatt 2235301 tgcgatatat aaatcagcag cttctttatg aggatcaaca tacttccatt tttcttcatt 2235361 gcttctggaa agctgataat gttcaaatga agcgacaaaa agaacttgaa cttcatactc 2235421 ggatgctgtt tgtaaaattt catcttttac cggacaagca tcagcatcga caaaaatcgt 2235481 cttttcttgt tcattaagaa gagtaattct ccatccctcc attaaactcc tgcataaaag 2235541 caagcaaaat cgcacatcct ttattattgt ggatgtatat gaatttgtcg aaaaatttcc 2235601 gggagaaatt cttgacatct tacccataat agtttattcg tatcacacga tccttaaacc 2235661 taaaattaat cattttatca caatttttta ttataataca aacttcacaa agatgctatt 2235721 gtttttcatt attccctttt ggcacagcca aaaacccagg atagagcgtc ctgagttata 2235781 tgttttttgt tttgagatga tggataatat ttgctgtttc ctcaaccgct ttatttgaaa 2235841 catcaacaac ctggcagccg atccgatcca caatcttttc gaaatactcg agttcctctt 2235901 tgattctgtt gatatttgca taaatcgctt tatcattaag cccgagtgat tttaaacgtt 2235961 cttttctgat atgattcagt ttatcagggc taatctttaa accgatgcat tttttcggat 2236021 caacgttaaa gagttcttcc ggcggatcaa cctccggtac aatcggaaca ttggcaacct 2236081 tcaggcgttt gtgtgcgaga tattgagaca gcggtgtttt agacgttctt gacacgccga 2236141 tcaaaacgat atcagctttt aaaatccctc ttggatcacg tccatcatcg tatttaactg 2236201 caaactcgat ggcctccact tttttgaaat aatcttcatc aagctggcgc acccgccccg 2236261 gttcgtattt cgctgttaaa ccgtaggctg tttccatttt atcaatcaac gggccgataa 2236321 tatcataata taaaacattt gctttttccg cttcggctat caaatattct ctgatttccg 2236381 gcaccacgag tgtaaaacag ataatgccgc cgtctgcctt tgcaagtgaa atcacttcat 2236441 tgatagtgcc tatatcttca acataaggaa ttcttcttac atgagtatca tccgccgatc 2236501 cgttaaattg gctgagtgct gcttttacta ccaattcagc cgtttcaccg acggaatccg 2236561 atacaacata gatgatgcgg ttattcatat tatccccccg ttagtttgca atcttatagg 2236621 atttcatttt cagataaact gacaagtatt ttggtcatat ttgtttttgt cactctgccg 2236681 atcacttcaa agcctttatc ggtgtctttg atgacaggca gtgcatcaat ttgtttttct 2236741 attaagtgct ttgcaatgtc catcacataa tcctcgcgtc tgcacaccgt aatgttcggc 2236801 atccttgtca tgatgatgtg aacagggacc gatgtaagct cctgctggcc aatgctcgct 2236861 ctgagcaagt cttttcgtga aagcaccccg actaaaacag catcgcggtc caccacaaac 2236921 agagtaccta catcttctaa aaacatggtg caaatcgcat cgtacacaga aacgttttcg 2236981 tgaatcacta cggggataga ttgaaagtct ttcacctgaa gctttttgag tttatccgcc 2237041 aaaagctgtg tgccggtttt tcccgtatag aaataaccga ctctcgggcg cgcctcgagg 2237101 aatcctgaca tggtgagtat ggctaaatcc gggcgcaatg tcgccctggt taggttcagc 2237161 ttttctgcaa tatgctcccc tgtaatcggc ccgttttctt ttacaatctg caaaatatgt 2237221 tcttgccgtt tatttagttc gatcgtactc accacctttt cacttcatag ctatgtaaag 2237281 aaataacaat ccatattata acgtaaatat cttgtaatca aacaaaaaac ttataaatgg 2237341 ggaaaagacg attaccgatc acacagcaac cgccttttct ctctttattt tacaataagg 2237401 gcattcatat tcgcaaagga cttgatctca tccgccaagc ttaccatttg cgctaaacga 2237461 tttgccttta atgactcatt atccgctata accattgtat gatcgaagta agcatcgatc 2237521 ggttctttta aggctgcaag tgaagcaagc gccgcctcat aatctttttt gctgaagttt 2237581 tcctgcagat tttgcttcgc tgtttggtag gcatcaaaca gttttgcttc gtattcattt 2237641 tcaaacagat caggctgaat gtctccgcgg actccttttt tgctgataga gatcactcgg 2237701 cctaacgctt cggctgtttc cttaaagcca ggtgcaccaa gcttttgctc cagtacttgt 2237761 gctttatgca gcgcagagta cggctcaagc tcagagcttt ccagcacggc gtcaatgaca 2237821 tcatgtctga tttgttcagc attcaagaca tatttcaagc gctgagtgaa gaaatccagc 2237881 agttcatttt ctttatcggt ttgaacgaaa gtaagcagct cttcaaatga aattccccag 2237941 ttgcggtcaa gaagaatcgc aacaataccg cttgcttggc ggcgcagtcc gtaagggtcc 2238001 tgggaaccgg tcggaattac gccgatagag aagaatgaag cgattgtgtc aagcttatcc 2238061 gccattgcta caacagctcc ggtgaaagta gaaggcgttt ctccgcccgc tgatctaggc 2238121 atataatgtt cattaactgc cgcagccaca gcttcatctt cgccaagcat tctcgcatac 2238181 ttttcgccca taattccttg aagttcaggg aattcatata tcatatgcgt cacaaggtcg 2238241 aatttagaaa tttcagcagc ccgcttcaca tgttttaatg tatcttcatc agcctgaaga 2238301 cgaacggcaa gtttctctgc gattgatgtg actctcctaa ccttatcagc aagagaacca 2238361 agctcttcat ggaaaacgat attttcaagc ttcttcacat ttgcatcaat gtttagtttc 2238421 tgatcttctt tgtagaagaa tgaagcatca gataaacgtg cgcgcagcac tttttcattg 2238481 cctcgggcca cattttcaat cgcgtggctg ttgccgtttc ggactgtgat aaagtgaggc 2238541 agcaggtcac cgtttttgtc tttgacaggg aagtagcgct gatgctcttt cattgtcgtg 2238601 acaagcactt cttcaggaat tgacagaaac tcggattcaa atgaaccgta aagagctgtc 2238661 gggtattcta ctaaatgatt cacttcatca agaaggtctt cgtcaactgg aatgctccaa 2238721 ttgttttcag cagccattgt ttccagctga gattgaatca tttgctttcg gacgctagga 2238781 tcagcaataa catgctgtcc tttgagctgc tcttcataag ctgaaggtga ttcaattgac 2238841 acttcatgtc cgaggaaacg gtgtccctgt gttgtccgtc cagactcaac gtttgtgatc 2238901 gaaaatggaa tgacatcctg tccaaataat gcgacaatcc atttgatcgg tcggatataa 2238961 cgcaaatctt catttcccca gcgcatgttt ttcgggaaat gcaagcttgt aattaaaccg 2239021 ctcaattctg gcagaagcga cttcgtttct tggccggctt ggaatttttg cacgaataca 2239081 tactctatgc cttttacttc tttgatgtac aggtcttcca catttgcgcc ttggcctttt 2239141 gaaaagccga ttgccgcttt tgtccagttc ccgtccgcat caagggcaat ttttttcgca 2239201 ggcccttttg cttcttcttt tatatcatcc tgcttttctg cgacatcctt aacgaacaca 2239261 gcaagacgtc tcggtgtatt gaagagtttc acttcaccgt gagtaatatt tttttcttta 2239321 agccagcctg tcagcttgtc gccaagctga accatgcttt cattcaaaaa gcgcgccggc 2239381 atttcctcta atccgatctc taaaagtaaa tcctgtttac tcatgagaag aaccctcccc 2239441 tttaagcatt gggaacccta gtttttctcg ttcctcatag taggtttttg ctacttttct 2239501 agctaaattc cgcactcttg cgatatagcc cgtccgctcg gtaacagaga tcgcaccttt 2239561 ggcatcaagc aggttgaaag tgtgcgagca tttcagcaca tagtcatatg ctggatgaac 2239621 aagtccgttg tccatttgct tgatcgcttc tttttcatat gtgctgaaca attggaacag 2239681 catatcgacg tctgatgttt caaacgtata aacagaatgc tcatattcag ccatcatgaa 2239741 taaatctttt actgtaaacc ctgacgtcca ttccaagtca aacacgtttt ctttatcctg 2239801 gatataagac gcgagacgct caattccata cgtaatctct acagaaacgg gtttacactc 2239861 taatcccccg acctgctgga aatacgtaaa ttgtgttatt tccattccgt caagccaaac 2239921 ttcccagcct agacccgcgc agcctaaaga cggattctcc cagttgtctt caacaaagcg 2239981 aatatcgtgc tcaagcggat caattccaag agcacgcaag gaatccaaat acagctcttg 2240041 aatgttatca ggtgacggtt taataatgac ctggaactga tgatgctgat acagtctgtt 2240101 cgggttctcc ccgtagcggc cgtctgccgg acgtctggaa ggctctacat aagccacttt 2240161 ccacggctca ggaccgatac tgcgcaaaaa tgtatacggg ctcatcgtgc cggctccttt 2240221 ttctacatcg taagcctgca taagcacaca gccctgactg gaccaatgct tttgcaaggt 2240281 tagaatcatg tcttgaatat tcatttcaag cacctccact tttctttcat aagttgactg 2240341 cggcagcaac caaaaaactc ccgtctctat gcttgccagc cgcaaacata gggacgagag 2240401 ttctcccgcg gttccaccct agttgctgag aacaaaatcc cagcctcttt tttaaaattg 2240461 ctcaagaatg cctttcgttg cgtgctcatc cttagcttac accgccctaa ggtcgctttc 2240521 atgaggtaaa cgcaagtact tctttctctc actgcaacat attttataat aaatgatcat 2240581 ataaaaagat ggaccaaatg tcaacttttg ttttcaccca taagatgttt catgctttcc 2240641 atttgatcta aaaagcgctt tgattttaaa tacaatcccg aatattcttc gtaatataaa 2240701 tcaatcactt gctttaattc agcttttgtt tcctctttta aggacacatt gccgagtctc 2240761 gacagatcaa aatagtaaaa gagccttaac agccttgccg tttgcggttt aatcggtatc 2240821 ctgtaaggat ctttttcaaa acagcggtgg catataaaac cattatcacg aacagagaaa 2240881 tgaaaggttc cgtcttggct tttacaatgt acacaatgat tcagctcagg atacaggccc 2240941 atgacaccga gcatcttcat ttgaacaatg aaggtgataa catccggatc tgttccttca 2241001 ttcaactgtt ttaatgattc taatatgaat tcaaataaat aaggatttgg ctttttttct 2241061 tctgtgcctc tgtcgactaa ctcagcaaca taggcagcat atgctgttaa aaacaagtct 2241121 tccctgatgc ctctcatgct gaggatcatt tccccctgct gaagcgttcc gaggcccgat 2241181 gttttttgca ttaagaaaga accatacaaa aagggctggc tgactgctga taaacggctg 2241241 ttcggttttt tggcgcctcg tgccataaca cctatttttc cgtgttctct tgtcagtaat 2241301 gttacgattt tattcgtctc tccgtaatca tttgtgcgaa gaacgatccc ttcacatttt 2241361 gtcagcattt ccgcaccttc ctcaagcagg agcggccaag aggtttataa aattggataa 2241421 tcaaatcggg ctagctcatc ttctagttct tcgggtcttt ccatgttctc tttttccagt 2241481 tctttaaaaa gaagatacgt atcaacattt cctgtttgag aaaatacgtt ccaggtaaaa 2241541 ttcaacacaa gaaacccacc tttctgtagt taaactagct tacctaaact ccaaattctt 2241601 acctttatct tgaccagatg tcctccattt catgttaaac aaaatttgct aatgtatccc 2241661 tgttcctgtg agataatgac acacacggga agagattaat attcgtcctc tttaaagcca 2241721 aaatcgcgaa gctgggacat tttattacgc cagtctttct gcactttcac ccacaattca 2241781 aggtagacac gggagcccaa cagtgcttca atatccgctc tcgctctttt tccaacctct 2241841 tttagaaggc ttcctttttt accgatcacg atgcctttct gggaatcccg ctcgaccaca 2241901 atcgttgccg ctacgtgcac agaaccgttg tcctgccctt tgatggattc gatggccacc 2241961 gcaatgctgt gcgggatttc ttctctcgtc aaatgcagca ccttttccct gattaattca 2242021 gaaatgataa atcgttcagg gtggtcagtt acctggtcac tcggatagaa ttgcggccct 2242081 tccggcaaat acgcttcgat ctgcgcgagc aaggtttcga tgttatttcc ttctaaagca 2242141 gaaatcggaa caatttcctt aaaaggataa cgtttgcggt attcgtcaat tagcagaagc 2242201 aattggtcgg gatgaatttt atcaattttg tttacgatta agaatacagg cgtagacatc 2242261 gtctgcaatt tctcaatgat gaattcgtcg cccttcccgt agccttcctc agcattgatc 2242321 ataaacaaga tcaaatcgac ttcttttaat gtattttgcg ccactttcat cataaagtcc 2242381 ccaagtttat gcttaggttt atgaatccct ggtgtgtcaa taaaaatggt ttgtgatgtg 2242441 cctgtcgtca gtactccttg caccttgttt ctcgtcgttt ggggcttatc gctcatgatc 2242501 gcgatttttt gtccaatgac tctgttcaaa aatgtagatt ttcctacgtt tggtcttcca 2242561 ataatggata caaatcctga tttaaagctt tcgttcgtca tgtaaatcct ccgatgaaaa 2242621 tgcgcctggc aataattctt ccacagtcat ttcttttatt tgtccttgta aattagtcag 2242681 tacgacaata acgtcttttg tgcaaagctc agaaatcacc tgtcggcagg ctccgcacgg 2242741 agatactggt ccaggggtgt cagccgcaac ggccagcatc tgaaactctg tatccccttc 2242801 agaaacagct ttaaataaag cggtacgctc ggcgcaattg cacatgctgt atgccgcgtt 2242861 ctcaatattg cagcctctgt acacttttcc atccttggta agaagagcgg ctcctacttg 2242921 gaatttggaa tacggcgcat atgccatatc acgcgctttt aaagcttctg ttattaattc 2242981 ttgtctgttc atgtgtacat tcctctctta cctataatgg taccgctatc actttatatt 2243041 ttacataatc gcgcgctttt tttcacgccc atttctaaaa atgtaaaata aatgtaagaa 2243101 ttttcagcca ttacagcttt ggcaaaaaaa taagtaaacc aatgatacac gaaatcacgg 2243161 caaaaacgca aacagccccg gcggcagcgt ccttggccgc tttagcaaga gggtgatgtt 2243221 tgtcagttat taaatcaacc gtatgttcaa tggctgtatt taaaagttca agcgaaaaca 2243281 taccacctat caaaaggaat ataatcatcc actcaataat gctgagctct acaaggaagc 2243341 cgcaaatgag aacagcgcag gcggctgcgg catgaaattg gaaattccgc tccgtccgcg 2243401 ctgtttccca tatgccccgg cctgcatgca cgaagctttt gaagaatcga ttcagctcat 2243461 ttctatgatc ttttgagtcc ataagcgtcc agcaattcct tttgcttagt aaacatctcc 2243521 tcttcttcct ctttcgtcat atggtcatat cctaaaaggt gcagaaatcc gtgtacagct 2243581 agaaatccga gctctctttt aaaagaatga ttatactcct ctgcctgctc tcttgtgcga 2243641 tcggcactga tgataatatc acctaaaacc ggaggcattt cggcgcccac gatttcgatc 2243701 tcgccttctc cctcttcttc aagagcaaat gagatgacat ctgtcggagc atcctttccc 2243761 cggtattctt tgttaatctg atgtatgtca tcattggaaa caatcgtgac agaaacttca 2243821 gcctgatcct gaacgccttc acgctcagcg gcaaattgaa gcagattttc tacttctttg 2243881 agcatctctt ctgagacgct tcccgtttca tcaacgatat caatcagtaa actcatctat 2243941 ttcaccttct tagtagcctc cggatattca atccgggagt ggaaaattcc ttttaatgtt 2244001 gcacagagcg tttttgcgat tgtatccagc tctttaaatg tcaaatcgca ttcactgaac 2244061 tgtccgtcct gaagcttatc ggatataata ccccggacaa gcttttcaat tcgttcagga 2244121 tttggattgt gcatggatct gacggccgct tcaacactgt cggccactga tataattgcg 2244181 gcttcctttg actgcggctt cggtcccgga taacggaact cttcctctgt aatctggtcg 2244241 cctttttcct tcgctttata gtaaaaaaac tttaaaagcg aggttccatg atgctgctca 2244301 gcaatatcga caagctcttt cggaaattta tagcttctca gcatattcgc accgtctgtc 2244361 gtatgcgaga taataatatt tttgctcaac tgaggtgaca gcttgtcatg cggattgtca 2244421 atattcattt ggttttcaat aaaatattgc gggcgctttg tttttccgag atcgtgataa 2244481 tatgcgccga ctcttgcaag caaaccatta gccccaaccg cttcacaggc tgcctctgat 2244541 aaattggcaa ccattacact gtgatgatat gtacctggtg tttccgtcag tattttgcgc 2244601 aatagcggat ggttaggatt agacagctcg agcagcctca tggtggataa aatgccaaag 2244661 cccgtctcaa aaaacggcat cagaccgatg atcaatacag atgaagcaaa ccccgacaca 2244721 acccccatga gcattaacgt gccgatttca agacccgaca gcgcagtgtt ctggatcaat 2244781 aataaggata gaacgacaac catattaata aacgccacga aaagtccggt ctgcaaaatc 2244841 tttgatcttg cattgtgttt tcctaaaaat aatacacctg aaatgccgct gatcaaataa 2244901 taaatcccta tgacataatt gaatgttcct gtcacaccct gattaaacat catacttccg 2244961 caaatcgcaa gaatgatact tcccaaaatg gcaatgcgtt cattcatcag cagtttgatt 2245021 aagatggcgc cggccgcaat ggggaccaga tagccgatat tattatactc catcttctga 2245081 aacaaactga caacctccat gatcacaagc aaaagtgttg tgattatgga gaataacaga 2245141 atggattggt ttttaaactt cagattttgt ttctgttttt caaaataata tacaagtgtt 2245201 gcaatgaaaa gtccgatcat aatcaatagc ccgctgatcg gtttaaagag atttgagtta 2245261 tttaataacc cggtcagctc aagtttcctg tacacttccc gatcaatgag gtcattttct 2245321 tccacgagca cttgcccctg tttgatttga acctgctgga cattatctga ggcttcctgc 2245381 cgttttgcct ctgttgcttt cggatcgaag acgtaattcg gaataatagc aaaacgcccg 2245441 atttctgtcg cggctcccaa gtatttagac ggaatagaat tgctctttag ctctttttct 2245501 accttatcct ttgcatcaga tagtttatcc gaagggattt cactgctcat gaccgtattt 2245561 accgcggtaa tgaccgtatc tctgacaaaa gaaaagtctt cactgtctgc tttcagcaat 2245621 gtcttgatgg aatcctccga tatagaatca ttcacatctg atgtcaattt gtcctttaca 2245681 gatttgacca ttgatttttc cgatggtgat ttactgcctt cttccgatga ttttttcact 2245741 tcactaatac tgtcgaatat tgatgacaca aggtcaatcc gattgtctgt atattctttt 2245801 tttaatgtat attgatcttc aaccgcgtcc tcagcggctt gctttttttc ctctgtggct 2245861 ttttgatctt ctacggttgc cggagcgtaa atggtcttgt cgctgactga aaacaggtct 2245921 aaatcaagtg tttccggctt aacatgtaca aagagcaaag caaacataat ggcagccagc 2245981 agaagataca gcagtacatg catggagcgg gcatttttaa aactgctcca tttttttgag 2246041 ctgcttttgg tcttagcctt ctttttcaac acaagaacct cctcttgaaa catcaagccc 2246101 ataagcaatc ataaaaatga cccgataacg cgcgatcggg tcattcagca ttaattttgc 2246161 ttatcgtatg cttcaataat tttcgcaaca agcggatgtc tgaccacgtc tgtctggtct 2246221 agctcaatca tagaaatgcc gtctattcct ttcagcatct ccttcgctac tgcaagtccc 2246281 gatttgacgc ctttcggcag atcaatttgg ctaacgtcac ctgtaatgat cattttagag 2246341 ccaaaaccca gtctcgtcaa aaacattttc atttgagcag gcgtggtatt ctgtgcttca 2246401 tcaagtataa cataagcatc atcgagcgtc cgtcccctca tatatgcgag cggagcaatt 2246461 tcaatgatgc ctctttccat cagacgttct gtatgatctg ccccaagcac atcatggaga 2246521 gcgtcataca gcgggcgcaa ataaggatct actttttctt ttaggtcacc tgggagaaaa 2246581 ccaaggcttt caccggcttc cacggcaggt cttgttaaaa tgattttttt gatatgtccg 2246641 ttttttaaag catggactgc ttttacgaca gccaggtacg ttttcccggt tcccgccgga 2246701 ccaatgccga atacaaggtc attccgcttc atagcggcca cgtattcccg ctgtcccatt 2246761 gtttttacac ggattgattt gccttttgcg ttttttgtaa tttcttcttc atacatgctt 2246821 tcaaagtatt caagttcatt cttctttgcc attttgatgg cgtaaatcac atcacgttca 2246881 gagatctcta tccccttgcg aattaaagcg aggagcgatc ccagcagcct gtctgcaatc 2246941 tgaaacgatt catcatcgcc tgaaacataa atcgtctcgc cgcgcgtaat gatatttaaa 2247001 ttcagatctt tctccatcaa tttcaaaaaa gaatcttggt tcccgaagag tgaaagcgcc 2247061 tcgtccgggt ttttcagttt ttgattcatc gcaagtaaat gttctgtcat tcttcagtct 2247121 ccctgacaat aggtgtggtt tgaacgatat cttctataac ttggtagaga ataatcaact 2247181 ttactttacc attctcaaca gtctggtgca aaactttttc acttttcacc tcgccgtttt 2247241 cgcctatttt atcctctaca tcctgtttac ccaatttaat gccttcttga actgcttctt 2247301 cttttgtata ttttcgcaaa gcctcttcac tttctctcgt ttgctctttg acataggata 2247361 cagggagctt aaatccgaga aaatgaagcg aatgcttttc ttgttctgtt tttggatgct 2247421 tcaattcctc ttttttaaac gtcatccccc agatcgggat tgccaaagaa ccaaaagaaa 2247481 gcttgtgctt tgtccttact ttgcccgtat agacgttaaa taatgtttca agcgggactg 2247541 tcacttctga tctataccag gtttctccat aaatttctgc ttttgaggcg acttcctgct 2247601 gatggtcttc gctgccgatc agtcccgaaa caagcagctg tcccttttca acatgatcgt 2247661 gtatggcggc catgggctgt cctttttgca caaacattct cgtaatggtt gctttctttt 2247721 tggcgacaat attgcgcggg ctaacatatt tttctttttc gggctcattt ttctccacaa 2247781 ctttcatatg aatggtcgtc cccttcagat caactccgac ccaagtgata ttgtctattc 2247841 cattggttaa tgatttctgt attttttcgg gcgacatcat taaaaactgc agacggccct 2247901 ttttgacgcc gatttcatta agatgctgcc tcatttgatg ttctgtttca ggcttagcgc 2247961 ctgtcacatc aattttccac accatattgg acagcaaaaa caaaagaatg aaaaaaatcg 2248021 caaaaccgat cgtaaaccct atattcagct ttgatttcag caacaggaag ggaaatccct 2248081 tccgattgat aaatcgggct ttacatttaa atttacttct tacccgccga aaggcatgta 2248141 catcctgaag ctgtatatat aacgatacgg cttctttctt ttttttgaca tgaaagaccg 2248201 gaatcccctg tcttgtgcat tcattaagga gccgctcaat ccctcttccc gtcaattcaa 2248261 gctggacctt acccgaaaaa aaagacagcc atttattttt cacaacattt ccccctcggc 2248321 tttatgactc aacatatcga acgacatcaa tcgtaccctc caaaagtatc tcttccggaa 2248381 gaatcgcctt gatgacaaaa tttttaccag atatgatgca ctggccctgc ttcagcatca 2248441 gccgcacttc attctcactg aaaagcaaaa ggcctctgtg gttttctatg tagatatgaa 2248501 gtctgccaac cattgtaatc ctcggcagat ccatcataac gtccggggga atttccaatg 2248561 ctcttgtcag ccaagctttc atacgattct ttctttgccc catacaaaaa gaaccccctt 2248621 tcatctcata tgtatgattt gaaaggaggt tctaacactt taatttttac gggccgggcg 2248681 catcgtacgg tgaggttttt tcgcccgtgg aggtccgaac acctctccta gaacgatccc 2248741 ctgtacgacg gtgtctttat tcacctgaag cattttttgt tttgtgtata ctgttttttg 2248801 tttggcagca gcaagatctc gttccagccc tttcaggttt cttgctgttt ccctgcgtct 2248861 ttcttccgct tcccgtcttg cctgttccat acggttaggg ataggtgcag gggcatcttc 2248921 ttttgactgc ttcttttgag gagaagcaga ttgcacgtgt tgaggttttt ttcttttttg 2248981 gctgttttgc ttttcttctt tgctcttttt gccgaaaatc gcagaaatga ttccgatgat 2249041 cgctgcaata ataagcggat tggtcagtaa atcttccatc agcgttctcc cttcttagag 2249101 agattatgat ttgcggtctt catccgaagg gtctttcgtc agcttgccga atgaatcacg 2249161 catttctgtg tcagcatcga tgttcttgat attcatgtaa tccatgacgc caatattccc 2249221 ttcacgcaaa gcttctgcca tcgcaagcgg cacttccgcc tcggcttcta ctactttcgc 2249281 gcgcatttct tctacgcggg cacgcatttc ctgttcttga gcgacagcca tcgcacgtcg 2249341 ttcttccgct tttgcctgcg cgatgttttt atcagcctcg gcctgatcgg tttgtaaaat 2249401 tgccccgatg tttttgccga tatctacatc tgcaatatca attgagagaa tttcaaacgc 2249461 agttcctgag tccaatcctt ttccaaggac tgtctgagaa atcatgtcag ggttttcaag 2249521 cactttttta tgattatcag atgaaccgat tgtagaaacg attccctcac ctacacgagc 2249581 tacaatggtt tcttcccctg ctcccccgac gaggcgctcg atattcgctc ttactgtgat 2249641 tctcgctttc gctttcactt caatcccgtc cattgcgacg ccggcaatga acggtgtttc 2249701 aatcacctta ggattaacgc tcatttgaac agcttccaac acgtcccggc ctgcaagatc 2249761 aatggcagca cagcgctcga atgtgagttc aatgttagct cgctgagcgg cgataagcgc 2249821 gttgacgact ctgtcaacat tacctccagc cagatagtgg ctttcaagct ggtttgttcc 2249881 aacattaagt cccgctttat gcgctttaat cagcgggtta acaacccgat tcggaatgac 2249941 gcggcgaagc ctcatcccaa ctagagtgaa aatgctgatt ttcactccgg ctgccaaagc 2250001 tgaaatccaa agcattacag gcacaaatgt aaaaaatact gccaaaacaa tgatcgctac 2250061 tgcgacaatt gccagaatca taagtgttga cggatccata taacttctcc tcgtttctat 2250121 ttaaatttct ctcacgacaa tgcgtgagcc ttctactttt atcactttta cttttttatc 2250181 tttttctgta aacgatccct ccgatacaac gtcaaggcgt tcatcatcaa taatcacggt 2250241 accggaagga cgcagcggtg taaaggttat acccactttt cccattaagt ccgtgcgcgt 2250301 ttgatttgaa acgtagccgc tctccgtgtt tgtagaatca tttaatatca atttcttaaa 2250361 gaatttcata cgctttccca acacccttgt cagtaaaata aaagctgtaa tcgaaacagc 2250421 tgaggcgatc aagagagaaa ccgccatgac agtgaagctc cccgcggcta aaaacaggct 2250481 cgcaataatc gctcccaagc ccagtaatcc aatgattcct ccgggaagaa aaatctcaag 2250541 cagaatgaga atcacccctg ctataaagag gagaaccgtc tcatacccgg caaggccggc 2250601 tgcaagatgc ccgtaaaaga acagcaataa cgcaatgagt ccagccgttc cagggaggcc 2250661 gacacccggg gaaaaaagct ctaccgtcag acctaaaaaa gcgattgtca gcagaatagg 2250721 gacaatgacc ggattcgtca gccatcttgc cgtcttttcc gcaaagctct cctttgcata 2250781 gctgatctgc gccttttcga acccaagctt ctttacgagc gtggacaaat tgtcagcagt 2250841 gccttctgaa tagcctacct caatcgcctt gtctgcgtta agtgtcagca gatctccctt 2250901 aggcgcgcca acttccttgg catctatatc tgggtcagcc attgcgagcg catattttgg 2250961 atcgcggtta tttttcactg cggcatcttc catctctgcc agccaaagtg attgagcttt 2251021 ttggtcagcg gcattgcctt ggccatcaac aatcgcggcg gctcccattt ttccgccagg 2251081 cgccatataa atgtgatctg cttgaagtgc aatatatgca ccagcagaca acgcgcgttt 2251141 gttgacatat gcagttacgg ggatctcgct ttcggttatc aaatcggcca tatcaatagc 2251201 agatttgacc aatccccccg gggtattgat atcaagaata atatggtctg catgtgcatc 2251261 ctttgcgtct tgtaacgaac gggacaaaaa cgaggcgaga ccctgttcga catttttttc 2251321 aaccgggatc acataaacag tttgtttttc tgcttttgcg ttcagctgta cgcctaataa 2251381 agaaagtaaa aatataccca aaagagcagc acggaatcct ttgatttgaa gcaagggcgg 2251441 tgtatccctc cttcctttta taataagtgc cttctcttca tacgtaacaa atgtatcaaa 2251501 ggtttcattt ttttatgtat aaaaaaagac atctctctta gaaagatgtc cttttctttg 2251561 ccatttaaga cagttgactg ctcacaagct tattaattaa acttccgtca gctttacctt 2251621 ttactttagg cataattgcc cccatcactt tgcccatgtc cgcttttgag ctcgcaccga 2251681 cctccgcgat ggtttcattt acgattgtac gcagctcttc ttctgacagc tgctcaggta 2251741 aataaacttc taaaatgtcc agctcttttt gaactttatc tactaaatct aaacgattag 2251801 cgtttgaaaa ttcctggagg gagtctttac gttgcttaag ttcacgagaa aggacagtga 2251861 gttcctcatc ctcggtcaaa ctgtctttct taagcttaat tgcttcattt tgaagtgaag 2251921 ccttaaccat tcgaacgaca gtcagtttgt ctttctcacg gtttttcata tacagcttca 2251981 tatcctggtt gagacgctca agaagactca taaatccacc ctcttttaga atttgcgttt 2252041 tctagcagct tcagactttt tcttgcgctt tacgctaggt ttttcataaa attcacgctt 2252101 tcttgcttct tgcaaagtac ctgtctttga tacactgcgt ttgaagcgac gaagagcatc 2252161 ttcaagcgat tcgttttttc taacgaccgt ttttgacatt ctctttccct ccctccgaat 2252221 acaccaatcg actaccttta agttacacat ataaacatgt actttgacat tataatataa 2252281 gccatcagtc aggtcaacta agtgagttca cttttccgtc atgagtgcga ctgcctgtct 2252341 atataatgaa agaaaggggt tggtgaatag gatgttaatt ctgattagct ttactgctct 2252401 tatattattc tttctcgcag gcatgaacat gcttcgaaag ggcttaattt caatggcgta 2252461 ctcaaaaatt gaagaacgtt tgcttttatt tacagaccat ccgttaaaag cgtttcttat 2252521 cagtattgta tttacgggga tacttcagag cagctcagcc tttatggtca ttgtcatcgg 2252581 ctttgtaagt gcgggcgttc tttcttttaa gcggacgatc ccgatgattc tggggacaaa 2252641 tgttggctct acttttacaa ctgaatttat tgctatcaaa atggatattg tgatttgggt 2252701 tcttttaata ggaggtttat tgttttttct gactggcagg tatcctttga aacagctggg 2252761 aacaagcttc cttggactgg gcatcatctt cttttgcatc agcggattca gccatcttgc 2252821 cgggccgctg acaaagctga aaacgggcgc cgacgttcta taccatgtta acgattcaaa 2252881 ctggtccgct ttgctcatcg gcatggtgtt aactgccatc attcactcca gttctgtctg 2252941 tatcggcatt ttgatgagtt ttatgaatga agggattatc ggactgacac aggcgatgag 2253001 cgtcgtactc ggatcaaata tcgggacatg cattacagct gtcatggctg ctgtatccgg 2253061 cggatatgcg gcgaaacaga cagcatatgc ccatgtggta tttaacgtgc taggggtggc 2253121 tctagtattg ccttttctga ccgcagcgac cggctttgta gagcagttat cacctgatcc 2253181 cgcacaaaag atcgcgcatt tcagcctttt atttaatgtg gtgacagctc ttttatttct 2253241 tccgcttaca aacttgtttt accgattgat tcaccttctt atcccggcta aataaaaaaa 2253301 tcggtacatt ttaatgcacc gattttttag gttaagaaga caaacgcatg tgttcagtta 2253361 tttcatcctc aaccacacgg acaaactgtc cttcgttgta aggataacct gcttttagga 2253421 ttttgacttt tacgattttg ccgatcatat cttccgtacc tttgaaaaca accttcatat 2253481 aattgtctgt gtaaccgaca aacatatttt cttcttctgt ttccttaaac gcttcctcag 2253541 ggataatctc aagcacttca ttttcatact gagaagcgta ttcttttgca agctggtcag 2253601 aaagagcaat caggcggtgc acacgttcgt ttttcacgtt ttcatccact tggtcttcca 2253661 ttcgtgcagc tggtgttcct gtacgcttac tgtaagggaa aacatgcagc tcagagaatt 2253721 tatgttcttt aataaagtta taggtttcca taaattcttc ttctgtttct ccagggaacc 2253781 cgacgatgac atcagaagta acagctaagc ctggcagtgc ttttttcaat ttatttaaac 2253841 ggtctgcaaa gaattccatt gtatatttgc gtctcatccg tttaagcact gtgtttgatc 2253901 cggattggat aggaatatgc aaatgattca ctatcttatc tgagcggtct aagacctcga 2253961 tcacttcgtc agtgatttgg ctggcttcga ttgaagaaat tctgatccgt ttcacgcctt 2254021 ccacacgggt gtctaattcg ctcaaaagct tcgcgaagtt gtaatctttc atatcttcgc 2254081 cgtagccgcc tgtatgaata cccgtaagaa caatttcctt atatccggca tcgacaagct 2254141 gctgcgcttg tttaatgact tcttcagggt cgcgggagcg gagcaggcct ctcgcccacg 2254201 gaatgataca gaatgtgcag aaattattgc agccctcctg tattttcaat gacgctcttg 2254261 tgcggtccgt gaaagcaggc acatcaagct cttcatatac tcttgctttc atgatgttgc 2254321 tgacgccatt aatcggctgg cgttcttctc ggtattggtc aatgtagcca agcatttttt 2254381 cacggtcctg tgttccgact acaatgtcga caccggggat cgccataatc tcagcaggtg 2254441 aggtttgcgc gtagcagcct gtgacacaga tgacaccgtc aggattttga cgaatggcgc 2254501 gtctgatcac ttggcggctt tttttatctc ccgtatttgt aaccgtacat gtattaatga 2254561 catatacatc agctgtttgt tcaaagtctc ttctttcata gcccgcttct ttgaaaagct 2254621 gccagattgc ttctgtttca taatggttga ctttacagcc aagcgtatgg aaagcaacag 2254681 ttgccattac tgatcacctc ttaataactc tgtttgataa gaaatcgcac tcaacgcgta 2254741 tagcggagcg gtttctgtcc ttaaaattct cggtccaagg ccgcacgtca caccgtcttg 2254801 ctctgtgagc cgttcaacct ccgcttctgt taaaccgcct tcgggaccaa atacgatcaa 2254861 tagagatgat cctttcggaa ggctgcttac aatcgcgctg aatgcgctta tttccccttg 2254921 cttcgatgac tcctcgtatg caacgacaca tttatcgaaa tcctgcatcc tttgaagaag 2254981 ctgctgaaaa gaatggacat ccatcactcg cggcacttcg ttacggtacg attgctcagc 2255041 cgcttccttc gcaattttcg tccatctttc ccgctttttc tttgcctttt tgtcatccag 2255101 cttgacaaca gaacgcgcgg cttggaaagg aataaaggca tgagctccga gctcagtccc 2255161 cttttggata atccattcaa gcttatctcc tttcggaagg ccgctcgcaa tatagacctt 2255221 tatcggaagc tctctgtttt cattcgtcca ttctatcaca aggcaggaca ctttatcttt 2255281 ggaaacagat tgaagttcac attttgcctc gaagccgtct tgagagcagc agataatctg 2255341 atctccctca ttcattctca tcacgttcac aatatgatga acttcttcgc cggtaatcga 2255401 aaaagtcggc gcttcctcta tttgctgctt cgtgagctcg ataaaatatc gttgcatacg 2255461 ctgtgacacc tactaactgt tattttttcg caataatgct gacccaatct tccattgaaa 2255521 ggatttctac aatggtaaag ccagcttgtt ccagtgcttc ttttacttct tgttttttat 2255581 gaccgatgat tcctgacgta ataaagtgac cgccttcttt taacaggctg tacgcttgtg 2255641 aagtaaagcg aagaatgact tcagccaaaa tgttggccac aatcacatca tgttcccctt 2255701 caatcccgtc taacaaattg ttttgcttca cttgagcaat atcgctgact ttgttcagct 2255761 tgagattgag gcgtgcactt tctacagcca cgggatcaag atcgtaggca tgaaccgatt 2255821 cagcctcaag cattgcagcc gcaatactta aaattcccga accagtgccg acatcaatca 2255881 ccttatcacc cttttgcaca aagcgttcaa gcgcctgaat gcagagtacg gttgtcggat 2255941 gtgtccctgt gccgaaagcc attcccgggt ccatttcaat aatcagttca tcagtatgga 2256001 ccggcgtata ttcctcccac gtcggcacaa ttgtaaactt ttcagaaatt ttcacaggat 2256061 gataatactt tttccaggca gtcgcccact cttcttcatt tacttcagaa atagtgatgt 2256121 ggtttctgcc caaatcaata ttgtaaagaa ggagattatt aatcgtttct ttgatgccgt 2256181 ctacagtttc gcccagaaaa ctgttaaccg gcagatatgc tttgacaatg acaccctcat 2256241 ctgggtaatc attggggtcg agctggtaga tttccccgta cacattctca cgttctttaa 2256301 ttaaatcaag cgggtcctct atcacaaccc cacttgcacc agcttcatgc aatatatttg 2256361 agataggttc gaccgcttca tgtgttgtgt gaatgcttaa ttcggaccat ttcaaaacta 2256421 ccaactcctc atccaataat taatcgcctt taaacgcgcg ttttaccttg tcaaagaaac 2256481 tcatttcctg ttcgtcaggc aggtttccgc tgacttcggc aaattcgcgg ataatgtctt 2256541 tttgtttatc agtcagattt gtcggcgtaa cgacgcggac gacgatatgc tggtcaccct 2256601 gtccatagcc tctgacattt tgaacgcctt tgcctcttaa tctgaatttc gttcctgttt 2256661 gtgtaccggc cggaattttc aatttcactt ttccatgcag cgtcggcact tctacctcat 2256721 ctccaagagc agcctgagca aacgttaacg gcatttcaca gtaaatatca tcgccgtcac 2256781 gctcgaagaa ctcgtgtgcg cgtacatgga acacgacaaa taaatccccg gcagggccgc 2256841 cgtttattcc tggttcaccc tgtcccgaga gacgaagctg ctgcccgtca tctacaccgg 2256901 ctggaattgt cacattgatt ttcttgcgtt ttttgatttt tcctttgccg ccgcagtccg 2256961 cacatttgtt tttaatgatt ttgcctgtac cttcacagtg gtggcagacc cgtctgttaa 2257021 cgacttttcc aaacggtgta ttttgctcca cgtttaactg gccggagcct ccgcagtggg 2257081 agcatgtttc tggatttgtt ccaggtttcg cacctgagcc tttacatgtt tcgcacgttt 2257141 cctcgcgggg aatttcgatg gttgtttctt taccgaaagc cgcatcctca aacgacaggg 2257201 tcatcgtata ctgtaaatca gcaccctggc gcggagcgtt tggatctctt cgtcttgtgc 2257261 ctccgccgaa tatacttgag aaaatatcat cgaaaccaaa accgccgaaa tcgccgccgc 2257321 caaaacctcc gccgccgaag ccttggttag ggtcagtgtg accaaattga tcgtaatgcg 2257381 cacgtttttg gtcatctgac agcgtttcgt atgcttcttt tacctcttta aatttttcat 2257441 ctgatccggc ttctttgtta atatcaggat gatatttttt tgacagcttc cgataagctt 2257501 ttttaatttc atcctttgaa gcgctcttac ttactcccag cacttcatag taatcacgct 2257561 tactcatctc gcttcactct cccgaatttc tcacataaat tagattgtat cattttgaat 2257621 tatgattttt caattccttt tatcccgggc aagaaaaaaa gtcaaagcca agagatgcct 2257681 gactttgact ttctaatcat tgaatcagat tatgaaatgt gttcttttcg gtcagctccg 2257741 gaagcggggc tgacactaaa aagaacttat tttttgtttt ggtcgtcgtt tacttcttcg 2257801 tattcagcgt cgacaacgtt gtcatccgct ttgccttcag cgtttgctcc gccttgagct 2257861 tgctgtgctt tagcagcttc ttcataaagc ttcatagaaa gctcttgaac gattgtttga 2257921 agctcatctt ttttcgcttt gatctcttca aattcgtttt tctcaatcgc tgcttttaaa 2257981 gcgtctttgg catcgttggc ttttttcact tgttcttcgt ccactttgcc ttcaagatct 2258041 tttaatgttt tctcagtttg gaaaacaagc tgatctgctt cgttgcggac ttcgatttct 2258101 tcttttttct tcgcatcagc gtcagcattt tcttccgctt cttttaccat gcgttcgatc 2258161 tcttcatctg agagacctga agaagatttg attgtaatgt tttgttcttt tcctgtgcct 2258221 aagtcttttg ctcttacgtt tacgataccg tttttgtcaa tatcgaaaga aacttcgatt 2258281 tgaggcacgc cgcgcggtgc tggcgggata tcagtaagct ggaagcggcc gagtgttttg 2258341 ttgtcggcag acattgggcg ctcaccttga agaacatgga tatcaacagc tgtttggtta 2258401 tcagcagcag ttgagaacac ttgagatttg cttgttggga tcgtcgtgtt gcggtcgatc 2258461 agttttgtaa acacaccgcc cattgtttcg ataccgagag aaagcggtgt aacgtcaaga 2258521 agaacaacat cttttacgtc acctgtgata acgccgccct gaatcgcagc accaagcgct 2258581 acaacttcat ccgggtttac gcctttatgc gcttcttttc cagtttcttt tttgattgct 2258641 tcttgtacgg cagggatacg agttgatccg ccgacaagga tgactttgtc gatttcgctt 2258701 gcagaaagtc ctgcatcttg aagcgcttga cggacaggac ccattgtgcg ctctactaaa 2258761 tgagaagaaa gctcttcgaa tttagcgcga gttaatgtaa gttcaaggtg aagcggtcct 2258821 gcttctccag ctgtgataaa cggtaaagaa atttgcgtag aagatacgcc ggaaagatct 2258881 tttttcgctt tttcagctgc gtctttcaaa cgctgaagcg ccattttgtc ttttgacaaa 2258941 tcaatgccgt tttctttttt gaattcagac accagatgat cgatgataac ttggtcaaaa 2259001 tcgtccccac ccagacggtt gtcgccggca gttgaacgaa cttcgaatac accgtcgcca 2259061 agctcaagga tggaaacgtc gaatgtaccg ccgccaaggt cgtatactag gatcgtttga 2259121 tcttcatctg ttttatcaag tccgtatgca agcgctgctg cagtcggctc gttgatgata 2259181 cgttctactt caagacctgc aattttacca gcgtcttttg ttgcttgacg ctcagcatcg 2259241 ttaaagtatg caggaactgt gataactgct tttgatactg tttcgccaag atagctttca 2259301 gcgtatgatt taaggtgttg aaggatgata gcagacactt cttgtggagt gtaatccttt 2259361 ccttcaattt caactttata atcagtaccc atatgacgtt tgatagacat aattgtgtta 2259421 gggtttgtaa tagattggcg tttagccact tcccctactt gacgttcgcc gtttttaaat 2259481 gcaacaactg atggcgttgt gcggtttcct tcagcgttag caataacttt aggctcgccg 2259541 ccttcaagca ctgccacaca tgagtttgtt gttcctaagt cgattccgat aactttactc 2259601 acttgaataa cctcctgcta tgtaattatt gattcacttt gaccatggaa gggcgaatga 2259661 cgcgatcctt cagcttatag cctttttgca tttcctcaac aacaatgttg gagccgtagt 2259721 tttcgtcttc agcctgcata acagcttggt gcagattagg atcaaattcc tgccctacag 2259781 cttcgatggc ttcgacgcct tcttttttca aggcttctac gagctgacgg tggaccattt 2259841 ccattccctg gagcaaactt ttcgtctgtt cattgtcggc ttcaacctga agcgctcgtt 2259901 caaaactgtc aagagccggc agcaaatcag tcacgatatt ttgagaacgg tatttttggg 2259961 acgcttccat ctctaaacgg ctgcgtcgtt tatagttttc aaagtctgct tgaacacgca 2260021 aaagtttgtt ttctttttcc tcaagcaaac cttgcaattc gttaatttgg ttttgaagaa 2260081 gttcgctttc atttgtttct tcctgctgtt catcagcggc agcttgttct tcaatgattt 2260141 cttgctcttc tgtttcgttt tgttcaacgg tttgtttttc ttctgacatt gtgttcacct 2260201 ccctcaaagt gtaaggagaa ggacaggtgc tgcccttcga taaaatttgc caaaattccc 2260261 ttattcatca tacagacttg ttaatgcttt tgacaagtcc gaagtcacat gctgaagcag 2260321 gctgacaacc ctggaataat tcatgcgggt cgggccgata atcgcaattg agccgatctg 2260381 cttctggtct acggaataag aagccgtaat cagactgcaa ttttccatct cttcatagtc 2260441 gttttctttt ccgattttaa tcgaaattcc cgtgtgcggg gattgaacca gctttaaaac 2260501 atcctgttct ttctcaatta atgaaagcag cgaccgaact cgggtgatat catggaactc 2260561 aggctggttc agcatattga ttttcccgcc aaaaaacaac ttttcaacgt gatttgtgga 2260621 atgaaaggtt gaacgaagcg cgtcgagtat attgtcatag tttttaatgt gctgtcttag 2260681 gtacatgaca acttctttaa atatgcgctc attcagttca tccattggaa cgccgcttaa 2260741 acggtcgttc agtatattta ccagtttttc aatatcagac agatccattt tggtcggaaa 2260801 gttaatcgtt ttgttttcca catgccccgt attggtaacg agaatcgcta ccgccatatc 2260861 aggctgaatc ggaatgattt gaatctgttt aaggtaattc tcactcaact tcggcccgag 2260921 tacgatggat gtgtaattcg tcagatcgga caaaatttgc gctgattttt gaactgtctt 2260981 ctccagctcg aaaattttct ctttgaagat cgagtggatt tggtccaggt cgcttttcgt 2261041 caatttgacg ggtgacagca aatggtcaac atagtaccga tacccttttt ctgacggaac 2261101 acgtcctgag gatgaatggg ttttttcaat aaagcccaat tcctccaagt cagccatctc 2261161 gtttcttatt gttgcagagc taaatgtgat ttcatctttt ttcgaaagag ttcttgatcc 2261221 caccggctgt gccgatttaa taaaatcgtt gattataacc tgaaggatca gcagctgacg 2261281 atttgttaac atcatcatca cctctgttag cactctcaat aagcgagtgc taattctata 2261341 acaaaagtat caaaccacaa gaaaaatgtc aattataact cacccaaaaa agcgccaaaa 2261401 acttcattgc ctaataattt cccttgatga gtcaaataaa cggcagactc cgaattgtga 2261461 atcagccctt tttcagcgag gtcttttaac acgcttggga aaagtccatc cagggaacgg 2261521 ccgtattttt ctgcgaatcg ttttttgctg acaccggctg tttttctcaa acctaaaaac 2261581 atttcttcct caatctgttc ttctgttgtc acttcatgtg tatctctgta cggaaaaccc 2261641 ttttcagcta tcaggtcaat gtaatgctta acaggtccga cgttcactgt tcgtgtgccg 2261701 ccaatatatc cgtgagcgcc agctccgaaa ccgaaatatt gttcgttgct ccaatacgtt 2261761 agattgtgct tagattccat gcctgcctta gcaaagttgc tgatttcata ttgatgaatg 2261821 ccgtgagctt ccatcttgct catcactatt tcatacattt cagcttcctg ctcctgcggc 2261881 ggaagatgaa gccgcccttt ttgcatcaaa ttataaaata ccgttttcgg ttctacaata 2261941 agggagtaaa cggaataatg ctcagcgtcc aatgataaag cagtgtttat ggaatgttcc 2262001 agatgcttga gggtttgccc cggaagcccg aacatgagat caagactgat attctcaaaa 2262061 ccgatttccc gcgctctttc aaaagaggtg aatacatctt tttgcttgtg cactcggccg 2262121 attttttcta acagatcgtc ttcgaacgtt tgcacaccaa agctaaggcg atttacgcct 2262181 gcttctttta atatttttaa tttctctgcg gacaaatcgt ccggattcgc ttcaaccgca 2262241 aattccgata agtcgcttga gggctttagc acgcggttga tcatatccat cagcttttta 2262301 agctgttcct cagacaggga ggtcggcgtg cctcctccga taaagattgt tttgagatca 2262361 ggctgcccgg tttttgctat tgtatttatc atttcctgtt cgagtgcgtt taaatactcg 2262421 tcgactggct gactttgaat aaaatattta ttgaaatcgc agtagtggca aatatgctca 2262481 caaaatggga tatggatata agctgatttc aacggattca ccttctttac agaaagaagc 2262541 cgcagtacaa gactgcggcg gcttctattg ttttttcgga ctgtcgtcca ttttcagaac 2262601 tgccataaat gcttcttgcg gcacttcaac tgagccgacc tgcttcatac ggcgctttcc 2262661 ttctttttgt ttttcaagaa gtttccgttt acgcgagatg tcccctccgt aacatttagc 2262721 caatacgttt ttacgcattg cttttatggt ggagcgggcc acgattttct ggccgattgc 2262781 ggcttgtacc ggaacttcaa actgctggcg cggaatgagt tctttcagtt tttcaacgat 2262841 cacttttccc cgttcatatg cgtaatcacg atgcacgata aaggaaaggg catcgatttt 2262901 ttcaccattc agcataatgt ccattttcac aagcttggac ggtttgtagc cgatcagttc 2262961 ataatcaaag gacgcatagc ctttagtgct tgatttcagc tgatcaaaaa actcatatac 2263021 gatttccgct aatggcatat cataaatgat gctgacacgg tttgcgtcta aatactgcat 2263081 atcaatgaaa ttgccgcgtt ttccttggca aagctccatt acagcgccga catagtcatt 2263141 cggcaccatc atcgtcgctt ttacgtatgg ctcctcaacc ctttcgatct tttgaggatc 2263201 cggcatgttg gacgggttgt cgacaacgac cttttcgccg tctgtcatat acacgtcata 2263261 gataacgctt ggcgctgtcg taatcaggtc gatgttgaac tcacgctcaa ttcgctcctg 2263321 aatgatctcc atgtgaagca tgcctaaaaa tccgcagcgg aacccgaatc caagcgcttg 2263381 cgaagtttcc gcttcatatt gaagggagga atcattcagc tcaagctttt caagagcttc 2263441 ccttaaatca ttatacttcg ctgtatcaat cggatacaaa ccacagtaca ccatcgggtt 2263501 tagcttgcgg tatcccggca gcgcttcttc tgcaggattg gcagcgctcg ttattgtatc 2263561 accgacacgt gtgtcaccaa catttttgat tgaggcagtc aggaagccta catcaccgac 2263621 cgtcagttca tttgtcggag ttgctttcgg cgtgaacacg cccacctctg ttacttcgaa 2263681 ttctttgccg gttgccatca ttttgatttt ttgtcccggc tttaccgttc cttcaacgac 2263741 tctgatataa gccacgacac cgcggtaggc gtcataaagc gagtcgaaga tcagcgcttt 2263801 gagcggcgcc tccggatctc cggtcggagc tggcaccttt tctacgattt gttctaaaat 2263861 ctcctcaatc ccgataccgg cttttgctga agcaagcacg gcttctgatg cgtcaaggcc 2263921 gataacgtct tctacctctt ggcgcacacg ttcgggctcg gcgctcggaa ggtcgatttt 2263981 attgatgacc ggaaggattt caagatcgtt gtcaagcgct aagtagacat tggcgagcgt 2264041 ctgcgcttca atcccctggg ctgcatccac gacaagaatc gctccctcgc aggcagcaag 2264101 gcttcgggat acttcatacg tgaagtcgac gtgtcccggc gtatcgatta gatgaaagat 2264161 atattcttct ccgtcttttg ctttatattt aagctgaaca gagtttaatt taatggttat 2264221 gccccgctca cgttcaagat ccatagaatc gagcaattgt tctttcattt ctcgttgagt 2264281 gattgccgac gttttttcta aaatacgatc cgctaaggtc gattttccgt ggtcaatatg 2264341 ggcaatgata gagaaattcc gtattctcga ttgcctctct aaacgctttt ctttatctgt 2264401 cacaatctat cactcctact attaaacgca aaatacacta gcttagatta tatcaatagg 2264461 attgtaaaga ttcaatgtaa aacaagaaag agaaaagttc cctatcatat ctgggttgct 2264521 tttctctttc acgtacttat tgattcatat cccgtatcca ttcatacatt gactgggcag 2264581 tattggttac ggtgtccgaa agcgcttttc cggcttttga aaacatattg aatgtctcca 2264641 ccttttccag ctctttttgt ttttctacta aatcttttgc cgtgactgtt tctcctagga 2264701 ttgaggcttc tttttcatta tcttttccgt cggtgagcgt aaacgccccc ttcagtgaag 2264761 ggtcatgata gcctttcata ctcagcatcc cgtggtttgc ctgctgcatg ccgaacagaa 2264821 cgcctaaaaa catgatcgtg acaagcagta agcactttcc aaagtatgca atcaaatcaa 2264881 ccacctattt cttattgttt tttcgtctcc ccgctcgctg cgttgacctt ttcagcatcc 2264941 cagtacattt cgctgaatac gtccgcggcc gcgttagccg cacgctgcag ctcttcgaga 2265001 ttattatcca ctccgccaaa ctcgagcaaa agcgctctat cggttaaatc ctgattgtaa 2265061 acaccattat cgcctggcga gcctttggaa aagacacctg tgctaagtcc ggggtatttt 2265121 ttctccatca gtttatgaag ctcactcgca attttatagt tttcttcgaa gtttttgctt 2265181 tttttcccga cgacaaaggc taccctggca tagcttttcc ctttaatcgt tgcggttgtg 2265241 tcttttttgc gccgagagtc tctgtggatg tcaatgatat attgcagatt tttgtttgaa 2265301 gcgagggcgt ctttcacgac cggccttgat tcatcatagg acctggcata gtttaagcct 2265361 tttttattca attttgactg tatatcggtt ttattcactg tggctccgat tccctgggat 2265421 tcaagcgctt gtccgaacat atctcctaca agcgtgacat tggctttaga atggcgcgcc 2265481 atgtcaggat cggtctcgcc ttttaataga gggagatatg attccgtatt gtgcgtgtga 2265541 tagataaaca cgaccttttt atcacctgtt gtttgtttcg gcggatcttt ttgcgcatta 2265601 tctgattgcg tttgctgttt ttcaatctct gccaaattcg cttctctttc ttcctccatc 2265661 accttagacg gcggcggcga ttccgcaggc atattcgtat aatccgttcc ttgtccagct 2265721 aacaaaatct cggtatcaaa ttgtgcaaat cctggcagct cccgaccgag aaagctccgc 2265781 ggatcttcga ggttaatgct cgtcgccagc tttaaagaaa gacgagaaag atgaaatgag 2265841 ctgtctgttt gagagaggtc agaagcgaaa taatggtttt ccatctgcag caaatgtgca 2265901 aatacgtcac ccggcaattc ttcagcaatc ccataaaaag agtcagacga cggcctaagt 2265961 tccggccgga gagacgtcag cacaccggat agaacaaaaa tcacgataag gcttacgata 2266021 aatagaaaga tggcttttac cgctttccct ccatttaccg caacaacaat ctgtctgttt 2266081 ctgcgtttat ttctcattga atccctccag cgcttgtcta gtaattactc tatgaacaag 2266141 ctagaggaag tagaactgtt tagtgattgt aggagccttt gttttcttgt gacacttttt 2266201 catgaagcgc tgtgtttaat ccgttcgcta aaacatttgc catatcgtcg ataaatgaat 2266261 cgacttcctt cggtgtaacc attaagttgt gccctaaagg cgaaagcacc tcgtgaatga 2266321 gctgccgttt ttcatcttct tgaagggttc cgacaatacc taggaacgat tggcgctgct 2266381 tttgatcggg aagatcgtct tcagtgagca ctttcttttt cccaaacgtc atgcctgccg 2266441 gaacaagcga tcttgatggc ctgttatcct tcatttctct gccaaaatgt tttaatatgt 2266501 agtccaccgt gtcgctggca attgtcacgg catcaactac tgtcggaaca ccgatagcaa 2266561 tcaccggaac accaagcgtg tctttgctta aatcttttcg tttattcccc actccagacc 2266621 ccgggtgaat gcctgtatcc gatatttgaa tggttgtgtt gaccctttcc accgcccgcg 2266681 ccgccaacgc atcaatggcg atgacaaaat caggcttcga ttgctcaatc acacctttaa 2266741 taatgtcact tgtttcgatt cctgttatcc ccattacacc cggtgcaaaa gcactgacag 2266801 gcctgtaacc ctcctgtacg ttttccggct gaagcttaaa caagtgcctt gttaccaaca 2266861 gattttctac tgccatcggt ccaagcgcat caggtgtcac gttccagttg ccgagcccaa 2266921 cgatcaaaca gctcgcatct tttgagatat taaggttttc aagaaaagct gagaattcct 2266981 ccgcaaagac agcagagacc ttctcctgca tttccgaatc attctccctg attccctgtg 2267041 cttcaagcgt taaatagcgc ccttcttttt ttcccgaaag ctctgcgcct tcctttgtaa 2267101 catcaactgt gcggatttta atgccgccgt gatcacgctc tttttcaata aagcctttaa 2267161 tttcttttgt cggcacagcc tgctgattgg ccattgcttc cttcgtttcc actgccaaat 2267221 cggtccgtat caaatactga ttcacatcca gctcactctt tttcatacag gggcctcctt 2267281 cacattaagt acctatattg ttgccatttg ctgaataaat catgctaaaa agagaacctt 2267341 caatgaaaaa tactttacat ttatattgca atctaaaggt gtgtttgata gaatacaatt 2267401 tgttctattg tgaagaagat ttaaccttaa gacactgtgc tacaggttgt atcttaggag 2267461 gtgaaacaca tgccaaacat taaatcagcg attaaacgta caaaaacaaa caacgaacgc 2267521 cgcgttcata acgcgacaat caaatctgct atgcgtactg caatcaaaca agttgaagct 2267581 tctgttgcca acaacgaagc tgacaaagcg aaaactgctc ttactgaagc agctaaacgt 2267641 attgataaag cagtgaaaac aggtcttgta cacaaaaata ccgcagctcg atacaaatca 2267701 agactagcga aaaaagtgaa cggactttct gcataatata aaaacgatcc tcaataatgg 2267761 ggatcgtttt tttcatttct ttttaacagc tgtaaaagga acagttcgag caggagctgc 2267821 ttgtcctttt tcccggtttt catctcatag tccatgacgg caagctgttc aataattaaa 2267881 cggagctcct cctctgaaaa aagccttgct tgatccatcg ccagctttac ccgaaatggg 2267941 tgaactttta gattagaagc gatttgtttt tgtccgtatc cctgttccgc gaagtacttc 2268001 gtctgcagaa tcagccggaa ctgattcgaa ataagcgcca taattttgat cggttcttca 2268061 ttttgtttta gcaaatcata aaaaatttgc agactctctg ttcgttttcg gttgacgatt 2268121 ttattgatca gctcaaaaat attttgttca aggcttctag caacaagcat ttttacatca 2268181 tccagcgtaa tttcttcacg atctccaata aacgtgcaga gcttttgaat ctcctgaaaa 2268241 atcgatgaca gatgaccgtt cacaagcaga accaaatgct ccgccgcttc cgtgccgatt 2268301 gttttctgct ctgtttttgc aaggttgaca gtaaagtctg tcgtttcctt tgcatttaat 2268361 tccttcgcct ccatcataaa cgcgtgcttc tttaacgctt tcgtcagctt ttttcgctca 2268421 tcaagctttt catacggagc aagcaggaca aagactgtgt aaggcgcagg tgattgtata 2268481 tatgattcaa gcgcactgac gttgtgctca attttttctt ttttcttttc acctgttaaa 2268541 aaatatggat ttttcacaat gacaagacgc cgctccccca taaacggaaa cgtttcagca 2268601 tctgcaatcg cttgatccag cgggtcctct tccagatcaa aaacggacag attgaaatcc 2268661 tttgtctcct gatcaacgac cgtctgtctg atcctgctga cggtttcttg cagcagatat 2268721 gtctcttttc cgtataaaca ataaaccgga tggacctctc cttttttcag gcttttccac 2268781 acatcaaata ccattgttgt acgacttcct ctctttcatc atccccttct atcctaaatt 2268841 gagtttgcaa aatagtaaag aggaagcctg actgctgctt ccccatttat attaaacgcc 2268901 tgttcgcaag cccccgggac agcttgtaaa aaggcgataa tcaccagaac agaaaacgtt 2268961 accttagctt ctagattttt caaaacaatt ccattatact taagtcagtc aggagggata 2269021 aagttgaatg attttgaaaa aaacgttcaa agcaaacgaa atgatgctgt agattcagct 2269081 gttggttttg ttgtgtcctt cggatttttc gccttcttgt ttgtcatggc aacggttatt 2269141 cacctagttg gttcataaca gcgactgccc gggctgctga tttctcggca gtctttttta 2269201 gttcgtctct gttatatctg atgtatcata tggaggatag acagaaaagg ttccaactct 2269261 gtttttgtat ctatattgga tcgttccgtt ttgatctgtt cgcagcacgc ggatagaatg 2269321 tctctgtaat agttgcagaa ctttttgatg aggatgatgg taccgattgt ttttcccggc 2269381 tgagataatg gccgttttcg gctgaagctg ttggatgaat tcttcaccgg tagagccttt 2269441 gctcccatgg tgccccacct ttaacacatc tgcttttata ttcggaaaca cgttcatcac 2269501 ctcttgttcc ccttctttct ccagatcacc cgtcaagatc cagctcatac cgcccgtctc 2269561 catccacaga acgagagatg aattattttt gcttgccgga tcaggtgctt ccggtgacag 2269621 tacatggaac tgcaaatcct ttatttgcaa cacatcgcct cgcttcacct cttcaattgc 2269681 cactccctct tccctggctg cctgcagcac tttctcatct ttaggttcag aaacgaaccc 2269741 tttcggaatc acgaggcgct ttactttatg atgcttcagc agaatctccg cctctccgat 2269801 atgatcttgg tcagcgtgcg tcagaattaa agcgtcaagc tgcttgattc ccttagcagt 2269861 taaaaacgga atcagcacct tttcccccag tgaaaacgga tgctgttttt cgcgccaagg 2269921 ctctgacgag taagacaaag tgccgccggt atcaattaag acacgacccc gctgatgcgg 2269981 agcacctaca aacatgctgt caccctgtcc aatatctatc atatccactt ctccttcgga 2270041 actaagacac ggatatataa agagcagaaa catcaccgtg cagcaaatgc ctccggttac 2270101 catcaactgc gacaaggagc gtttttcaat cgccataagc aataggatga tcgtgactgt 2270161 gaataaaaaa agcaaaacag gtgcaggatg tgcgatcata atcgtgaaca catcaacatc 2270221 tgcaatgttt gtgattaacc tattgatcca gcttatcaat aaatcaaacc agctgaaaaa 2270281 caatctccca aacgaagcgg aaagacttaa tagaagaaca cctgctacag ctcccggcaa 2270341 aatacagaag gtataaaatg gtaccatcaa catattcatc ggtacgctga tgatagaaaa 2270401 ctgatgaaaa tgatatagga gaatcggaag cgagcccagc tgagcgatga gtgatacaat 2270461 tgtcagctgc cccaaggagg ttttaacctg ctgaaaaata gaagaggata gaattaaaga 2270521 aaaactgacg gcgaacgata gctgaaaacc ggcttcaaag agatgataag gattgaagag 2270581 cagaaggacg atgtacgaaa ggcaaattgc agttgcagag cggacacgcc atttgacaag 2270641 acttccagct aagtaaacac ccgacatgag agcggcgcgt agcactgaag gagcagcgcc 2270701 ggtcaacatc acatagagcg gcagaaataa cagcaacaga attgacgcct tttctctagt 2270761 tataccaagg cggatcatga tataaaacaa acctgctgtc aaaatcccca cgtggagtcc 2270821 tgatattgcc aagagatgga caacaccaag cttttgatac gcggtaagca cttcatcctc 2270881 cacgtaaaat ctgtcaccaa ctgtaagtgc ctgtacaatc cctgtcgaat caggaggcag 2270941 aaggctgttt gtgaatgata tgatatgttt tctcaagctg agcaccttgt acttgaaatt 2271001 ttcaggttcg ctgcagtttt ggatagacgt gacagagtag ttccaatgaa tatgctgccg 2271061 ataaagatac tcgttataat caaatgcacc cggcacagtt gcgtgattcg gttcttccaa 2271121 tgtaccagtc aactcacatg acattcctgg ttctatgtat aacagctgtt ctttttcacc 2271181 agcagactga atgcgatacg cagcagccca tttttcctta tcaggtgtct caaccatcat 2271241 agacatacgg tcgccgtcaa ttttgggaat agtgtcaatc actgccttga attgataggt 2271301 tccctgccga taggaagaga cattctgaga atctgtgact gcatacagta caaaaaacaa 2271361 tataaaagag aagaaacaaa caataataag aaaagcgtgc ctcgttttga ttaaaatgat 2271421 gaggagaaag aggatgaaaa gaaaaatagc ggggaaataa gcggcggcag taattccagc 2271481 cgttgccgaa gctgccgcca taggcaataa taagcgcgaa ttacgcattc atcacacgta 2271541 gctcgtgaaa agtgtattcg cctgttcatg tatctttttc aattcttcct ccgctaaacc 2271601 ggcatcagcc aatttcccta ttagacccgc tacaaatgaa agcttttctc tgtttttcag 2271661 atcaacgatc atttcatcga gttcaacctg ttcaacagtt acacccgcct gttcaaataa 2271721 ttcctgcgca tacggatgtg ttttgtaatc ctcagcataa taaaccgttt tgataccagc 2271781 ttgaataata gatttgcagc attgaatgca cggataatgc gtcacataaa tctcggctcc 2271841 atcagtcggc accccaaact tagagcattg aagaatcgca ttcatttcag cgtgaatggt 2271901 tcttgcgcaa tgatcatcta tcattaagca tccttcatct gcacaatgta cgccgcccgc 2271961 gattgaccca ttgtagcctc ctgctatcat gcgtttgtct ctgactatag tagcgccgac 2272021 agataatctc ggacatgtgc tgcgcagcgc caataaatgg ctttgagcca taaagtattg 2272081 attccatgaa attcgttcca cgttgttccc tccaaatgtt gtgttgcctg acctttagtt 2272141 tacctatcat aatgcatgac cgtcaaatca ctttactgta atggaagact ttattttctc 2272201 aaatgacttt tcacctattc ctgaaacctt agtgatatct tcaattgttt ggaaacgacc 2272261 gttttcctcc cggtatgcaa taatagcttc agctttggat ggccccaccc ctgagatgcc 2272321 ttgtaactcc tctaaggttg ctgtattgat attcaccagc gctcccttcc ctccatcgct 2272381 ttggacagac cctccgccac cttgctgcac tgctgtttcc tctccctttt tcgggatgta 2272441 caccactgtc ccgtcctgca gaatctccgc caaatttact tgcgcttcgt ctgcttgttc 2272501 actggtcccg cccgctttct caattgcctg agatactctg tcccctgttc gcatttcata 2272561 aacgccagga tgctgaacag cacctttgat gtctatcaca attgtttcgt ttgactcgtc 2272621 gttgtttgct tcctgcttta ccactgtatt ttctgtctct gttggtacag cttgcttcac 2272681 cggctcttta tttttccctg tggccagaaa gatcataatc gctgtgaaaa cagccgcaga 2272741 agccgctaaa ataattgctt tcttatgctg attcaaccaa ttcatcgtgc atgttccccg 2272801 ctttcgtcat attttatttt cataacacat atggtttaga ggataatagc tcaaaggagg 2272861 ggaaaccatt gaagataggc tttatcggca caggaaatat gggtacgatc cttatcgaat 2272921 catttattga atcaaaagcg gccgatccct caaacatgac aatcacaaac cgcacaattg 2272981 aaaaagcgtt gcacataaaa aaccgctaca acagcataaa cgttaccgaa agtctcgaaa 2273041 agctcgtttc tgaaaacgag atgattttta tttgtgttaa gccgcttgat atatatcctt 2273101 tactggcaag agcgttacct tatttaagaa aagatcatat tctcatttca attacaagcc 2273161 ccgttcaaac cgaacagctc gaacaatatg tgccgtgtca agtggcgcga gtgatcccaa 2273221 gtattacgaa cagagcgctg gcaggtgttt ctctcgtcac tttcggcaca agctgcggcg 2273281 aatctgcaaa agcgaaaatc aatgagctga tgcagcatat ctctcatccg ctgcaaattg 2273341 aaagtgacat cacgagggtt gcatcagaca tcgtaagctg cggccccgct tttatgagct 2273401 atctgattca gcggtttata gatgcagctg tttcggaaac atcagtgtct aaacaggacg 2273461 cgattttgat gtgtaaggaa atgcttgtcg gaatgggaaa actgttagaa accgaattgt 2273521 ataccctgcc tgcattacag gaaaaggttt gcgttaaagg cggtgtaaca ggagaaggca 2273581 ttaaagcgct ggaaagcggt gtgcaggata tgtttcaccg ggtatttcaa aatactcata 2273641 tgaagtacga ggaggatatt tccgcagtga aaaagcagtt tcatgtgtag acgagtatgt 2273701 catacgttcg tctgtactgc aaaagcataa aaaagcattt taaaaaacca tcgttttagg 2273761 aaacgatggt ttttgatttc tgcgccttga aaaagaggcg ttctgattgt gctgatggct 2273821 cggtatccgt aaaatcagct gtcacgcgat ggagctgaaa gccgcagttc ttaagcattt 2273881 cttcgtattc ttccaccggg aacgttcttt gctcgtgtgt ctcatcaaaa cgatcatacg 2273941 cttctccgtt ccacacaaaa aacgacatat catgaatgac agaaagctcg tcacttccgg 2274001 caaagctctg ccaaatatag ctgatatctt cgtcctggtc agcaaatgtg ctatccggaa 2274061 agacttccgc aattttaaaa gatgaatgaa catcaaacag caggatgcct tcaggcttta 2274121 atacccgaaa aacactttta aaggtttcga tcacatcatt ttttgttttt aaataattta 2274181 atgagtcaca gcatatcaca acagcgtcaa attgaccgtc aaagccggta atctctctca 2274241 tatcctgctg aagaaataaa ataggctggc tactcgatac cttttgctgg gcgaaagaaa 2274301 gcatctcttc gctgagatcg atgcctgtaa cctcgaagcc tttttcggca agccggatgg 2274361 agatttcccc cgtgccgcat gccagatcga gaatacggcc tttttccggg agagatgctt 2274421 caatccattt tgtccattga tcgtaaggcg cgtgtgacat tagctcgtca tacacgcttg 2274481 caaagccttg ataaatcatt gattcattcc aaagtcaaga tctgcgagcg gagcgtctcc 2274541 ccacagcttt tcaaggttgt agtagcttct ttcatccttg tggaagacat ggacaactac 2274601 atcgcctaga tcaacgagaa cccatcttgc ttcatcaaag ccttccatct ttttgacttg 2274661 aatgccgttt tcatcagctt gatccttgat ttcacgggca atcgcctgta cctgtttatc 2274721 tgaatttccg tggcagatca gaaaataatc agcaaccaga gaaatacctt ccatatccag 2274781 tgctaaaata tcctctgccc gtttatcatc gcaagccgca gctgcgatct ttaaaatgga 2274841 cttttggttc attcacaaat tcctcctgtt cagctgccag acacaagcca gttatacgtt 2274901 aaaaatgtgt ctggaaaaac cggttgattt tttttcataa gaaaaaccat tgtattttta 2274961 atggactgaa tcagcgcttg attcaaatct gtctcagcaa gcttacgcac ctcatcgaca 2275021 ccgggaaatg cccggtttgg ctcaatgtaa tcggcaacgt aaatgacttt ttctaaaagt 2275081 gtcatgccgg ggcggcctga ggtatgatac ctaatggcgt caagaatgtc ttcatcttga 2275141 acccctgcct ctctttggac caaataagcg ccgaccggag cgtgccagag ctccggatta 2275201 tgatccaata aatgcgcagg cattttttca cgcgcaataa tttgtttcat ttcttctttc 2275261 gggcggaatt tggcgtaatc atgaaagatt gccgctattt ccgctttttt agaatcggct 2275321 ccaaaacgct ccgcaagttc gatcgccgtg ttcatcacgc caaccgtatg gatatatcgg 2275381 tgttcggtca attgctgctt cacgcatgca agtgcctcct cacgattcat ataaaccatt 2275441 ctcctctaca tacttcttca ctttatcagg gattaagtag tcagtgggct tcttgctttt 2275501 aaaccgttcc cttatcatag ttgatgatac ctcaaattcc ggaacgtctg caaagagaag 2275561 cggataaggg gtttcaacat gaaaaccggg gcgctttact ccaataaatt gaatgaggtt 2275621 cagcagctcg tccagcttat accatttcgg caaatattca atcatatcag cgccgataat 2275681 aaagaacagc tgatcatttg gataacgctg cttcagtaaa gaaacggtat caaaggtata 2275741 tgatggccct tctctttcca tttcaacaag ctccagctta aaggacggat tagattgaat 2275801 tgcaagcttt agcatttcca cgcgatgaaa gctgtcggta tagtcttcgt tctgtttatg 2275861 cggcggaatt tgattaggca taaaccaaat ttcatcaagc cccgcctggt acagcacctc 2275921 attcgccatt aagaggtgac cattatgcgg agggtcaaac gtgcctccga aaattccgat 2275981 tttcttcatt tcaaccacct ttaaggaagc tcgatttgtt tattttcctt tgattcctta 2276041 tataacacaa tcgtattgcc gattgtctgc accaattgag agcggcttcc ttttacaaga 2276101 gcttccgcta catcgttttt atcctcttcg caattctgaa gcacgctgac tttaatcagc 2276161 tctctcgctt caagcgcctc agcaatttgt ttaatcatgt tgtcgtttac tccgccttta 2276221 cctacttgaa aaatcggcgt taaatgatgc gcttttgaac gcaaaaaacg tttttgttta 2276281 cctgttaaca ttctgttcct cctaattttc ctattacaat agatctcatt ttttcaatat 2276341 taggctcttg tccagtccac aattggaaag acaatgctgc ctgttcaaca aacatgccca 2276401 caccatcgag tgttttcaag cctttttggc ttgcttcttt taaaagtgcc gtctgtattg 2276461 gattatacac gatatcacat acgacggcac tgctcgcggc acgctgtaat gaaagcggca 2276521 catcgtccac gttcggatac atgcccacag acgttgtatg gatgataaca tcatactgct 2276581 caagacgttc ttctgcttct tttatgctta atacttcttt attgtgaaac gagggagtag 2276641 cttctgtaag ccgctttgct ttttctaacg tccggttgca aatgtcaaat tttttcgggg 2276701 tatttcggac aattgttgta aaaatggctc tcgccgctcc gccagcgccg atcattaaga 2276761 atgacagttc agagatgggc ttgtctaata ccttcattaa tgacttcacg aagccttccc 2276821 catcggtatt gtatccgaca agcttatctc cctctcttct gaccgtgttt acggcaccga 2276881 gcacttttgc actctcatca atatgatcca aataatccat aatggaaacc ttgtgcggaa 2276941 cagtcacatt gattccttgt acgcctagag ctcttattcc ttttaccgca tcctccagat 2277001 cattctcttc taccttgaag gcatgataat gtccgtcaag cccgaggtct ttcaatgatg 2277061 cgttatgaat atcaggtgac atagaatggc caataggatt tccgataacc ccgtacagct 2277121 ttttcataca cctctcccct tttcttaaat taatgaacgc cgaacaaata catgaacgcc 2277181 ttttggcgcg tatgcagtta cctttttatc agcgtcatgg acagtaaccc agcctaaccc 2277241 agagaaaacg atatctgtct ttttgtcttt tatcgtaaac gtatgggcga ccaattcagg 2277301 aaactcatcc atttcatctt tacccggagg tgtgagcaat tcccctgcat gcttttcata 2277361 aagcgcgtct gcattttcaa gttttgttct atgaatcatc agctcattcg gcatatagca 2277421 aataaaagga gatctttccc cagacacata atcaaacctt gcaagtccgc caaaatacag 2277481 tgtttgctga tcattaagct ggaatgtgcg aggcttcagc tcctttttag gagataatat 2277541 tttcaggtcc tttttattga cataatgcgc catttgatgg ttgttgataa ttcccggtgt 2277601 atcataaagc gatgaaccgt catccagcgg gatttcaatc gcatcaaggg ttgtgccagg 2277661 aaattgggat gttgtaataa tatcttcttc acctgacact tctttaataa tccggttaat 2277721 aaaggttgac tttcctacat ttgtacatcc gacaacatag acgtcttttc cgttgcggta 2277781 atgctcaatc gcgtcaatta cttctctgat tccctggccg cgacccgcac tgaccaaaaa 2277841 tacgtcaacc ggttttaagc caagctcttt cgcttcacgc ttcatccatt ggatcagacg 2277901 ctctcttttc agtgacttag gcaaaatatc cgctttattg ccaactaata agatagggtt 2277961 tccccccacc aagcgctgca gcccattaat ccagctgccg ttaaaatcaa aaatatcaac 2278021 aatttttacg accagagagt ccgtttctcc aataccgtga agaatgttca aaaaatcatc 2278081 atcagttaag gagacatctt gtatttcatt atagtttttc agtctgaagc aacgctggca 2278141 aatcacattt tctttcgtaa gcgatgcagg cggcgcgtac cccaaacctg ttttgtcctc 2278201 ggtttggatc gtaactccgc acccgataca aacaaccttt tccatttctt actcctccca 2278261 ctgaatgtgc ccttttcgtt tgagagcact cagtattctg cgttcgacct ggcggttaaa 2278321 gcgcgtaatg aatccgtcag aggaagcgac tggcacgacc aaaatcgtat ggtagccgtt 2278381 tcggtttccc ccgagtacat cggtcagcag ctggtctccg atgacaacgc agtcctcttt 2278441 tttcagctcc atattgcgca ccgctctatt aaaggcttta cccatcggtt ttcttgcttt 2278501 atagatgaat gggattccaa gcggttctga gaaaagtttc actcttcttt cgttattatt 2278561 agagacaatt gtcactttaa tgccgtgttc cttcatttct tcaaaccact cgatcaatcg 2278621 cggcgtcgcg ttcggcctgt cccattcaac aagcgtatta tccaggtcag taataattcc 2278681 ttttacattt cgttccttta atttctcagg tgtaatatga aaaatatttt ttacaaactc 2278741 gtcaggtaaa aaaaactttt ttaacaaaac ccgcaccctt ccctttttct ttctttcaaa 2278801 atgattgtcg aaaaaaatcg aacttgcgcc taaagaaaaa ctgagcaaaa aaatttcgac 2278861 aaaaattggg tttcttcacc aggtgtggat aaatttacac acactatcca ctcttattac 2278921 atcactcttt agacaaatta taaacacgat actcacaagt tatccacttt ttggtgtgga 2278981 taacagaacg attgttctta tatgcatttc atggtagatt aaagataact tcaacctcag 2279041 atgaatgcaa cttatcattg tatgcgttaa aatcatgaat gattccaact tttaaggagg 2279101 tgcctctccc attaattggg ttcctagcat gagaaaactg tctgatgaat tactaataga 2279161 atcttatttc aaagccaccg aaatgaattt aaaccgtgac tttattgagt taattgaaaa 2279221 cgaaataaaa agaagatcgc tcggacatat tatttccgta tcttcttaat aggaatttgt 2279281 ctattttttc cgggcgtatt tccttttttt actcagatga ctgatattat atcactttgg 2279341 ctgcgcgctt tactactatt ttcagcaaaa aacaccccta aaaagaggtg ttttaaaggg 2279401 ccggttatta tgctaaccag tatatgccgc ccacaacaag gagaacaaca actaaaacaa 2279461 caataaaagc gtatccatat gctctgcctg cgccatacat gtgaagcgcc tccttaataa 2279521 ggttttataa cagcctatgt aggagaaata aatcggacta ggcggttgtc cggctcaacg 2279581 ctgcaggatc tgcccatctt gtattccttc atatacgatc cttgcccctt taggtgtcat 2279641 atgatttcca gaaggatcta taagaccaga ttggataagc gcttcatcag ttgcttttcc 2279701 gccgtctgct tctataaaat gcttccagtt atctacaaga gggacatcca ggcgcttcga 2279761 cacatctctt gtaatatcgt tatatgagtt gtgccatttc cttgctccgc cttttggttc 2279821 aaaagcagct gcttgatatc tggaatagta aaacaaatga tgcttcccat taccttctat 2279881 aattgggata cacgtcatta agattggctt gatcccgtgt tttctgcttt cttcaataaa 2279941 ataaaccaga ttttctctaa aacgctgctt cgacactctc ggtttcccct cagtcagtat 2280001 ggcagcgtca ttggttccga acataataaa caaatacttc ggtttttgat ccagcacatc 2280061 tgtctgaaat cggagacggg catcctctgt cgtctgtccg ccgattcccg cattgagtat 2280121 atcaaggtta ccgcgctcag ctgtttttaa tatattgacc cactgctgtg cttttggata 2280181 atcgcgataa tcccaattag agccacgcgt attactgtca ccaaatgcta caacgtcttc 2280241 gtatcccctt ccctcgcatc ctgctgtaac gaacagcaga aggaaaagga tgataaaatg 2280301 tttcatcttt acacccccaa aagcctcact ttaatgttat acctctgttt ctcttcgttc 2280361 aatgaagagt ttttcgctat cactgttttt tcctatagtt aacgtgtccc cctcagtgaa 2280421 tatcattctg ctttcattgc ggcgcagctg atgatttttt aaaattccct tctttccaat 2280481 ctgaaaaaca cacaaaccaa agaaaagaaa ataacctgaa tccgcactgg aaacaggtta 2280541 tccgttaaat cctgcattta ctttaacttc gatttaagct tggcctttgt ttttggccca 2280601 taaatcccgt ctgcagttaa tccgttcatg agttgaaaac gcttgacggc attcgctgtt 2280661 ttcggtccgt aaactccatc tatgccattg tttttggctc ccttatcagg gtaaaagtga 2280721 agtacagcta aagccttttg cagctggaga atgtttgtgc cctttcgata aggcgaagtg 2280781 agctttataa ccccagacgg cagaggatat gatggtgaag tttcttttgg aggtgtatcc 2280841 gaggaagaaa ttccgtttag aaaagagttc cagtggtcca agagtttccg cggacattct 2280901 ttcccggacc actttttgtg gggaacaaca cgatttaacg gaatattgtt ttccttcatc 2280961 agctttctga tcagccactg ggcatttgat gttgcttttt caaaatcgcc gtcagcattt 2281021 tcacagattt caatcccgat cgatttgcgg tttcctgtcc cgtttgtacc gtctcccgca 2281081 tgccagccgt tttcatctat cgggagatgc tgataaatga ctgaatcgtc aactgtaaaa 2281141 tgccagcttt cggatgtgtt cgggtttttc acaaacttgg cgtgcatttt cgcatcagcg 2281201 cctttggctg tattcgctgt attatgcacc gtaatataag caggcgccat cgcatagcca 2281261 ggacgattat catttgatac cggtataaaa tcctttttta tggttaccat ttctatccct 2281321 ccctattaat aagaatgcag aaaacagaga gatggacagc cttttttatg aggtaaaaaa 2281381 gaattgtgtt cttaacctgg ttttcagttg aacagctgaa atggcaccag ttatactaat 2281441 ttagatgacg gaggttttga ctcctgacat cacctaagtt gggagtgacc atagacatgt 2281501 taaaaaaagt aataggtata cttgtgatta tcgctatcat ttcagttggt ttttttcaga 2281561 aagaagcttg gcttgatgca atcaaagcag gagggatgtt ttccgtttta tttagtatgc 2281621 tgctgattgc tgccgatgtt tttttcccaa tagtgccgtt tgctttgatt gctgctttaa 2281681 atggcgcagt gttcgggact gcaaatggaa tttggattac actgaccggc tcaatgcttg 2281741 gtacaatatt gctgtttttt ctcgccaggt acagttttag agattgggcc agaaaaaaag 2281801 ttcaggccta tcctgccata caaagctacg aggcttcctt caacaaaaac gcttttaccg 2281861 ctgttttatt aggaaggctg atacctgtca taccttcact tgtaatgaac gtgatctgcg 2281921 ggctgagcca ggttcgctgg catgtttttt tctttgcgtc tttaataggg aaaatcccca 2281981 atattgttgt tgtcactatt gcaggtgcca atttcaccag caataaatta ttgtctatca 2282041 gcatttacgg tacatatatt ctgatcatca tgctggtcat ttataaaaag ttccctcatc 2282101 ttctgaaggt gccaaaaaaa taaggaggct tgttggcccc cttacttttt ttctgtcgca 2282161 tggcctccaa attcatttcg aagcgcagca accacctttc ctgtaaacgt atcgtctgtt 2282221 aaagaacggt atctcatcat tagtgacatg gcgatgaccg gcgttgccgt ctgcagatca 2282281 agcgcggttt ccaccgtcca ttttccttca cctgaggaat gcataatgcc cttgatctga 2282341 tccagtttcg catccttagc gaaagctcgc tcagtcagtc ccataagcca agaacgaatg 2282401 acagaaccat gattccacac tctggcaacc ttctcgtagt caaaatcaaa ttggctgttt 2282461 tcaagcactt cgaatccttc accaatcgcg gccatcattc catactcaat tccattatgg 2282521 atcattttta aaaaatgtcc gcttcccgct tcaccagcgt atagataacc attttcgacg 2282581 gcagtatcac gaaaaagcgg ttccacaatc tcccatgctt catgatcgcc ccccaccata 2282641 aaacaggctc catgccgtgc gccttccatt ccgcccgacg ttccggcatc gagataatgg 2282701 atacccgctt ctttcatttg attgtagcgg cgaattgatt ctttataatg agagtttcca 2282761 gcttcgataa tcatatcgcc tttacttaat aaaggtgata catcacgcaa aacagcatcg 2282821 acaatgccat gcggtaccat aacccatagg atgcgcggcg ggtgtaataa agaaatgaac 2282881 tctttaagat ttgttgtccc ctcagccccg tatgctttca gttcatcaac agccgcttga 2282941 tttacatcat atccaaccac ttgatgattg cggtcaatga attgctttcc tatgtttatg 2283001 cccattttcc ctaagccgat taatccgatt ttcatatctg ttcctcctga ttgtctaaaa 2283061 agcctttact ctttatgttc cctatggatt gtattgtgat acgcagaaaa caaatggggc 2283121 ttacatcgtc tgcgcatgta aattttattt ttcatgaccg acggcgcctg ccagttctat 2283181 tactgaatct ctttatatcc ataattatcg ctttatcctt gatttaccat cagtttaagt 2283241 taaaatatgg gaaggaattc gattttttca gtaaaaagaa ggtgacatgt tgcagaatca 2283301 atctcatact cttattggag ttacgaaaac cgctgtattc tttttatacg ctgcacttgc 2283361 aatcatcggt tttgcaatcg ggtattttat tccgcagatt gcgaaatggg cattatccct 2283421 cccctggatc cctcttgaag gaccacttcg gctcattacc tcttttcagg gatctacagc 2283481 ttcatttatc actgctcttc tcggtatgtg tgcggggatt tggttcgctc attctgttat 2283541 tgcaatgctg ctgtctgtca aaattacaga tcacacagtg gaattcatca aaggaaaaaa 2283601 agtgcaaaca attcattccg atgacatcgc tcttgtattt atggatcaca aacggcttgt 2283661 cctcctggga acagccggat atgaattggt acgggaagaa attgatgaaa aaccagtaaa 2283721 cgttgagaag gcctttagac agcatcatta cgaatgggca acagatggtg atccgtttaa 2283781 agatcaattt cgccgatgga ttcctgatgc accagaccta tcgcaaggcg cccatgcctt 2283841 attaaaagct cgtcacaaag cactgcagga cgaagaaaaa gacgatattg aagaattccg 2283901 tctcgaactg gcacagctgg gcatcgttgt acgggacgaa ggcacacgcc aatattggcg 2283961 aaaagcagaa acctatcccc cgaaaattca gctcggcgaa ggattgtaac aacagaggct 2284021 caagaaagag cctcttcttt actactgcac aataaacagc actctggtac cgtcaggata 2284081 gctgctcatt tgattcccta cccacgagcc ggcgccgcga ttatcagaag gcgtcacata 2284141 tcggacatca gcccctgcac cgccttcctc gcagaccgcc atcggccact catcccggtc 2284201 atagcccggc ttggtcggga ttccctttaa agattcctcc cgccttttgt ctgctccatc 2284261 tctgtcaatg gtacaaatat ctggatgtcc ctctgcaatc gcatccctaa tatgactgcc 2284321 ggtttccgga taacgagaca gcggaaaata taacactttg tcatacgaag atgcgccttg 2284381 gatctgttgc ggaaccatta aacaaagaag aactgctgca gcaagaaaca ggcctgccat 2284441 ccattttttc atccccatcc ccccatacct ttgttcattt caatgtatgg gcgcttgatg 2284501 aagaatattt ttaacatttg aagttagtat gctgcttacc aaagccggac tcccccgcga 2284561 gaaatttccc ggtacagaca cagacagcct cccggtcaca tacatttaca tataggcttt 2284621 tgcctacata cttttgtgga ggtgacgatg gtgacaggtg ttttcgcagc gctcggcttt 2284681 gttgttaaag agcttgtctt tttagtatct tacgtgaaaa acaatgcctt tccacaaccg 2284741 ctctcaagca gcgaagaaaa aaaatactta gagctcatgg ctaaagggga tgaacatgcc 2284801 agaaacatgc tgattgagca taatcttcgc ttggtcgccc atattgtgaa aaagttcgaa 2284861 aatacaggtg aggatgcaga ggacttaatc tccatcggaa cgatcgggct tattaaagga 2284921 attgaaagct attccgctgg aaaagggaca aagctggcga cgtatgcagc gaggtgtatt 2284981 gaaaatgaga ttgtaattac aaaagggggg tgcatacacc cctctttaat acgtttcaat 2285041 atatatggtg tcagaatcca caatggtaac ttctttcacg ataaagttaa caattgtttt 2285101 tttatcttca agagttaagt tatctgcacc gattgattga aaatagtcga tggctctttt 2285161 tagagcattt tcacttgagc tcgtatcatc taggactttc atttttgact ggatttcgtt 2285221 acacttttca gtaagctgat tttgcttttt ttgcagttca ataatttgtg ctttgatttc 2285281 atctatgtct aaatcatcgt catcgcttag gctgattagc gttaaaagac gcttgcggcc 2285341 tttttttgtt ttctctatct ctttttcaat aagttctaat tcatcagaca ggtgatttga 2285401 ttgttcagcc tctttaaaag aaacatactt ttgaggattt gtgatgaatt taaaaatttc 2285461 accccataca tgccggttca atttattctc agacatttct tttccgcagc cgcggtcctt 2285521 tgcgccagaa taatttttcc ggcaagtata tacatagtag tctttaccat gtgattttct 2285581 tttcttccct gtcatggtat ttccgcattt tccgcatcta accaaacccg ataacaagta 2285641 attgtgaggg ctgatactca agtgttttct tttactttga cctaagagtt cttgagcata 2285701 atcccattgt tcagctggaa caattgctgg aattgtcaca gtgatttgtt cttcttcagg 2285761 ccttatttta attatagatt tgttccctgc ctgctttgaa acataggaac cctctgtatc 2285821 atatttatac tgtctatgtt cacccttata ggaagagttc attaatattt gccgaacaac 2285881 ctgcctgtgc catactttgg cgcctttttt tgttttaacc cccatctgag ttaaatgtag 2285941 agcaatacca tttactctgc cgaaaaaagg gcttttatga tcggtgaaat agttaaaaat 2286001 catccgaatg atttttgctt cctcttctaa tatctcaaga gttcttttct ctttaacaaa 2286061 tttatagcca tatagtttag aatctttaat gatcatgcct tttttcattt tttgaagtcg 2286121 gccgcttgat gtccgttctt tgattttggc tttttcaaat tctgagattg ccccgcgcat 2286181 tgcgaaaaac aattgacctt ctggagaatt ggcgtattca ccatttacaa aaatcaaagg 2286241 tatgtttcgc tttcgcaatt cgtcatcaat gattagctga ttcattaatt tccgagaaag 2286301 acggtcagga tcgtaacaaa tgacttgact tataagtccc ttgcttgcat cctccctcaa 2286361 gcgattcaaa gccggacgtt ctaaaagctc tcctgaaaat ccttcatctg catacttcag 2286421 cacatcttta gtccctgctt tctttataca ggcctcgatt tggctgtcga tgctcgatcc 2286481 cttgatcgct tgttcctcgg tcgataccct tacatatatt gctatcaccc tgaatctcct 2286541 tcctataaag ttttattaaa taatgatagc aatcgttaat gcatttgtca gcttgcggtc 2286601 cctcgatgat tatcactttc ataaaatgca tcaccccttg ggtaatgcta tgtaacagct 2286661 gtttgtccaa atgaggagat tttaaattaa actatagtgt tattaaacgt ttcaatgaat 2286721 atgcaaaaaa tttaaaaaaa gttgttgtga cttttctaca ctcctttagg tcctcaatag 2286781 aaaagatttt attttctatg cctcaacatt cgcttattat agttttcaat gatttattat 2286841 tatttgagag tacaatggag tagtgttttt cattgttaga tagttaatga catttcactg 2286901 gtgtcaagtt cgtatagcta gacattaata aaaaaaggac acatataaat atgcatcctt 2286961 taacaaaaga gtttatttat ttccctgttt cagcaaattc cttcaaccta ttccctattt 2287021 catcacgaac tctttggaaa aacgcccatt tttcttcttc tgtcccttgt gctcttgccg 2287081 gatcatcaaa accccaatgc tcacgtttta catgtggagg cgtcatcggg catttatcag 2287141 cagcatctcc acaaagcgta acaactaaat cagcattgtt cagaatatca gaatcgatta 2287201 tatctgacgt ttgattagag atatctatac caacttcctt catcgcttta acagcattcg 2287261 gatttaatcc atgtgcttct atccccgcgc tatacacttt ccactcatca cctaaatatt 2287321 gtttagccca tccttcagcc atttggctcc ggcaagagtt ccctgtacat aaaaagtaaa 2287381 tgattttatt ctccatatat tccacctcta catcgagtga cttccaaagt attttcgttg 2287441 aaaccataaa gcaaccttaa caagtgctat catgactggc acttctacaa gcggaccaat 2287501 tacggcggca aatgctgcac ccgaatgaat tcgatatcaa gcttcgcact taaacacagc 2287561 ggaatttata atatatgctt ggacagccgt aaaagccgaa ctgaacaatg gtatgatttt 2287621 gctcatgaat tttgccatat atatagacat gaaggcgata aaaaaacaat gcctgcaact 2287681 tggactgatt atttggattg gcagtccaat tattttacat atcacttttg cattccaact 2287741 tgcatgttgc gtaatatcaa ccttccgtac atacaatcac atgcaattga aaatgtagct 2287801 tggttattta aggtatcccc ttcattcgct aagaaacgtt taagcattta ttacaggaaa 2287861 ctgactcaac atttatttag tcaaactgtt acgggaaatt tatgcccccc ctttttgtaa 2287921 tgaataatga aatcctcatg catttgcgcg cattgaaaaa aacaaaaaaa gacgtctccc 2287981 ttcacgatcc gatcgggcag gataaggaag ggaatgaaat aagcctgatt gacgttttga 2288041 aatcagaaaa cgaagacgtg atagatacga tccagctcaa tatggagctt gaaaaagtga 2288101 aacaatacat tgacatttta gatgaccgtg agaaggaagt gattgtcggg cggtttggac 2288161 ttgatttgaa gaaggaaaaa acgcagcgag agattgccaa agaactcggt atctcacgca 2288221 gctatgtatc gcggattgaa aagcgggcgc tgatgaagat gtttcatgag ttttatcggg 2288281 cagagaagga aaagcggaag aaggcgaagg ggaaataatg cagaagaagc cggatctcat 2288341 actccggctt tctctatttg aaagagttat gaaaatcatt tttttcatcg ctgataagct 2288401 ctccgagaaa gacaggcagg atcgtaacaa ataacttgac ttataatcct cccgcaggca 2288461 ttcaaagccg gacgttctaa aagctctcct gagaaaatcc ttagatcggt atacttcagt 2288521 acatctttag tccctgcttt ctttatacag gcctcgatct ggctgtcgat gctcgatccc 2288581 ttgatcgctt gttccacgat atattgctat caccctggat ctcctgccta taaagtttta 2288641 ttaaataatg atagcaatcg ttcatgcatt tgtcagtttg cagtccctcg atgattatta 2288701 ccttcataaa atacatcacc ccttgggtaa tgctgcgtaa tacctgtttg tcctaatgag 2288761 gtgattttca atgagtatga aaacaaataa aaaaaccgat ggtttgtacc atcgatctgt 2288821 tttctatatc actaggccct caatatagta aatctagctc attggttatg aaagcttatt 2288881 ttcattacac actatatatt catttgttat catttctata cgtttatatc aattatggta 2288941 aaaaatggtt acaaaaaccc aataaacgtc caacctaact ttttcatctt atttattaag 2289001 aattttaacc tcttccttgt gaaataaaga agcgattttc atctccaaac agttaatgct 2289061 atttcatcgg gacatgtctg ttaaagtagc caataaatac attcggatat ccacttacaa 2289121 ccacgattca atttgatcca ctacagattt ctgagctgac attaaacaga tagagttata 2289181 aaaatctgta ccagttccct ttcacaatta ggacatttcg gcggcgtttc ggcataatgc 2289241 gaactaattt attaatgttc aacaacagaa tttcgtctat tggcaataaa gaatccacaa 2289301 atcattgcaa gaatggccat cgcccaccag aacgttgaga tcgcctgatc atgatcgatg 2289361 ataatcaaac gaatgacagc tgtgatgcca atataaatga agtagcgaag cggaaaatga 2289421 aagtctgatt tgaagtattt gataatcaaa gcaatgaact caaagtacat gaagaatata 2289481 agcagttctc caagcatctc ataatagctg tccactttgt tgaacagtga cttgtatacg 2289541 aatagcacaa tgtaccaagt ctcgctgatc agaagtgcgc ttaaggctaa cgccagaaag 2289601 aacagacaga cgttgagaag cgcttgtaac aggtaaggca cctttttgaa tttgttagaa 2289661 aatctcatca tgttgtctcc tatttcaata tattcgtggt ttttattctc agcctacatc 2289721 ttggtgttcc aaaatcgtag cacaatgtag tacttagaat tcttttgtat actgtgaaac 2289781 tgtccctgca tgcgggacat cattcgcgca atgcttcttt caccgagtcc gttgctttcc 2289841 ggtgttatat ctgcaagttt aatcgtattg ctaacatgga tctcaaatat ctcttgatcc 2289901 gatacaaacg tgatactgat tttttcttcc ggatctgcgt atttcaataa gtttgacatc 2289961 acattatcaa atacacgacc aagctcctcc aaattcacgt taatataggt ttccggcagc 2290021 tcgcctgaaa tatggacccg aaaatgctcc tgatgaagga tagcaatctg atctgatatt 2290081 agatcgtaga tcacttcttt cactgcaacg gtctccagat cggcctcata ttccttgttc 2290141 agcaggaaat acgcaaacag attgtcagac aagcttttta attgcagtgc tttaccataa 2290201 gcattggcta cataccgatc tttgctggca cccgcttcgc ctccctcttt tttggcaaac 2290261 tccagattca tgatcagcga cgtcagcggt gtgcgcatat cgtgcgacat ttcggtaacc 2290321 aggctgcggc tctcagcttg caattcctcg atagctttaa gtttatccag gaaagctttc 2290381 cgcagatcct caatgctctt tgcaatcatc gctaattcat catgcccttt tatcgtcatc 2290441 tcgtagtcca gttcgccccc ttcaagaata tgaatctctt gatgaatcgt tttaaggtag 2290501 cgaagacttt ggcgaattcc gaagagaaca atgattaaaa agatgagggt tgccccgagc 2290561 aaatccaatg caaaggccag atcataatat cgggaagagt agaaaccgtc gataatgact 2290621 cgtccttcac catcgctaaa cttgacagga tgtgaatgat tttgagcgta ctgagtcagc 2290681 ttttcctttc cataatccga ttcggaataa atagaatcat attgcagctc ctgatccttg 2290741 aatatggtga ggttaatgta attttctttt ttgacccact cgccaaacgc ttttctatct 2290801 gatgtagaca actcattttc tgaaacgtac ttgctgaatt tttgaatgta tcttgctgac 2290861 tcctcgtgat aatactcttc cgaactcaga tatccctcga tcagatcatc tgtgatcttt 2290921 tgcaacgtca gaaagatcac accactcaca atcgcagcaa ccattatcag caaagccagt 2290981 tttttggtta gcgtaaattt aagatgcgcc aaatcgatat cctcttcccc attcagtttt 2291041 tatataaacc ggacgtgccg gatcatcctc aattttggag cgcagcttcc gtatatgcac 2291101 catcaccgta ttgttggaac agtaaaagta aggctgtccc cacacactct catatatatt 2291161 ttgggcagaa aatattttgt tgcgtttgtt catcagaagt ttcaggatac gatactccag 2291221 atctgacaac ttgatttgct tctcctcttt ccacacctca ttaaattctt cgctcactct 2291281 tagtttgccc ccgataagaa atgtttcttc ctgttccttc ttttcctgat agatagtata 2291341 tctgcgtaat tgagcaatca ctctagcgtg aagttcctct tccgagaatg gtttagtcat 2291401 ataatcatcg ccgccggcga gtaatccctc agttttatcg agtgtactcg atctggccgt 2291461 cagaaacaga atcgggacgt tagaggattt cctgatgtgc tgacatgttt caattcccga 2291521 aatgcctggc atcataatat ccaaaataac caaatcaagc gagtcattca caagttgcaa 2291581 tgctcgcttt ccatccttgg ctcttagcac ctcgtaacct gcacgtgtaa gggattcctc 2291641 caaaagatca ccaatatcct catcatcctc tacgactaat attcgatagg ccatgtctct 2291701 ctcacctcat gattcttgtt gttatttctc gtgtgtcctt actatatatc gttcatagta 2291761 ataagtacgt tataagatac tacgtaaatc ttaacaattt atgaaagctg atgctcgcca 2291821 caaatttgtc acattttcta aaaaaaatga tgactcttca taaattgtta agattcggtc 2291881 tttatattta tccattgtaa ggctcaagtt tttcagatcc gcactacaca ttgccgtgat 2291941 aaatgggaaa ggagtattga tatgattgta caaaaagaag gacgcgggca accggtgagt 2292001 ctgcgggaac gggttcattt tctggacatc gtacgaggat ttgccttgct tggcattatt 2292061 attgtcaatt attttctgat cgtagattca gtaaagggat tcgaaatggc ctccgatgac 2292121 gtactgcata agctggtttc ctggtttgcc gaagggaaat tcgttacgtt attctccttc 2292181 ctgttcggag tcgggtttat gatctttatg gatcgagccg cgcagaaggt agagagtccc 2292241 aacaagctgt ttgcccgcag gttatctatc ctgttgggat ttggcatttt gcacatcaca 2292301 tttgtttggg tcggtgacat attggccttt tacgccgtaa gtggcttcct gttactcgcc 2292361 ttctataaac gcacggccaa aacggtgctt agatggatta tcgcacttat cgtgtttcaa 2292421 ttcctgactc ctgttttcac aatgttgtac aatgtcatca atactgcagg gtcaaaaaac 2292481 ccgaattttt cagagtttac tttgtttagc cacagcagcc ttacctacat ggaatccatc 2292541 agcactcggt ggacagatat ggtcacgatg gctgccggct ctttctctat gatctattcc 2292601 atgtttctca tgtttctgct gggcgtgtac tttgttaaga tggaattttt caaagacatg 2292661 gaagcgaaaa agcctatatg gaagcgtatc tggatcatta gcacaatcgc ttttctaata 2292721 acacaaagca gtatattact agacatgttt aatctttctg agaatatgct gtggaaggac 2292781 atttcctctg tcttgggtca aaatggcggc ttaaccggaa gtatgtttta tatgagcact 2292841 tttgcaatgc tgtttctata ccttcctcag ctgcgaggcc ctatgatgat attcaccaaa 2292901 gtcggacgga tgtcattgac ctgttatctg cttcactcta tcattggaac agttctgttc 2292961 ctcaggtacg gattcgggct tgcggatcat attcaatccg ccggcacgtt catgttcagt 2293021 ctggccgtgt acttcgttct tatgagcttt agtacattgt ggttgaaacg gtttaggtac 2293081 ggtccgatgg aattagtatg gcgcaagctg acgtacggca aagtaaacgg gagtcccaaa 2293141 gcaactccgc tgcattcgga aaaatctatt cagaaataac ccccttgcac agattgcatg 2293201 acttcaaatt agtgttgttg aatgaagcgg gcattaaacg gacagatttg atatatggac 2293261 tagttatttt tatatcattt aggcttcttt gggctaataa atccaccaga gtttactcaa 2293321 tgtgcattgc tcatgatcga atctaaattg aatcttttac gcatgttcat agtcaaaggc 2293381 gcctcattcg actatttttg taacttttcg caggaaaaat tcgagaatga tgacaaatcc 2293441 cgcatacgac acttaatacg gtagtgaaca atagtaaatt agggttacat gcagcttgtt 2293501 ttccaatgaa acaaagaaaa agaatcatac aaaaagacag gagaaagctt ttgaagtatt 2293561 ttaacgccaa atttaccgcg gaagaaagag cgatggaatc acttttttgt gaaaaggcct 2293621 cgcagagcag ctcgaatgtt ttactgaacg actgaactct atattttagc aactgaggga 2293681 gtgaacaatc atgaaaacta aaaatgaacc aaaagttatt ctggaactag caaaggaatc 2293741 tgatctgcca gaattccaaa aaaaattaca agaagccttt gcgatcgccg tgattgaaac 2293801 gttcggtgat tgcgaagatg ggccgattcc atcggacaat gatgttcagg agtctttcaa 2293861 tgctcccgga gcagtggtat atcatattct tcaggatggt aagaatgtcg gtggtgcagt 2293921 agtacgtatc aacagccaaa caaatcataa ttcgctagat ttattctatg tatctccaga 2293981 atatcacagc caagggattg gtctttctgc ttggaaagcc attgaagcac agtatccgga 2294041 tactgtgctt tgggaaaccg tgacacctta tttcgaaaag cgaaatatca acttctatgt 2294101 gaataagtgt ggatttcata tcgtagagtt ctacaatgaa catcactcta atccgcatat 2294161 gcatcgcaat ggacgtgaag atgacaagcc cctactgaat gatgatgact ttttcagatt 2294221 tgtaaagatt atgaaaaaaa aggactaaac aattgaacac ggcgagatgc cgcagagagt 2294281 tgctggtaac ttttttatat ttcattatca gaggaaggta ataatgatgt ttaaaaggtg 2294341 ttttgatccc tgtctcataa acaggggtca aaacaccttt gaatcatcgg tttcttttct 2294401 gacatatacc acgcccacta gtccctcaac atagtaaaaa catatcatga gttacaaaag 2294461 cttttattca aagcatatgt ttattttatt tatacttatt ttcatcattt ttcagaattc 2294521 tggacacaaa tcgggtacct attagaggcc aaggaactct acatttcatt aagaaatacg 2294581 tactcattgc cctgctttaa ttaattttaa gccctcgcac tatgcccccc cctgaattaa 2294641 gtatttgatg taactttgaa attaagttta tgaaaatctg tcacaaaccc ttatttcata 2294701 acacatcatt tgtttcagct tccctcgcga ataccggatt aatgctcggc tttaagatag 2294761 tcaaccaatc tctccgcact gttcttaaca tcttcttttg aaagatgaag tgtcccatat 2294821 tgtgtaaacg caggaagaaa acgcattcct atatagttag cagtgacttg aaacggtctg 2294881 ataagctcgc tgatcgtgat attatattct ccgcctgctt gataatcaga ttcctgtgcg 2294941 cctaaggaga tagctaagag tagttctttt ccatgcaatt tagttcctcc agttccataa 2295001 gcccagccat gtgttaacac atcatcttcc cattgtttga gtaacgcggg actgctgtac 2295061 caatacattg ggaactgaaa aacgatacgc tcatgatcta acaggagctg ctgctctttt 2295121 tctacatcaa tgataaaatt agggtattca ccgtacaggt catgaaccgt aatgtctttc 2295181 tcttgcttta aacgattcat ccaggttttg ttgacaacag acgtttccaa attaggatgt 2295241 ataacgataa ctaatgtttt cattagactg attatccttt ctttgccaat tagttattat 2295301 tttttacgat aatgaattga ttctaatttt aaaatagcaa ctttatttac acctatttta 2295361 tcctttttca tgaattcagg gcaactaatt gggcaccaaa atcaatgatg acttaagaca 2295421 ttgttttgta gaaatccgat atacagaata atccattatt tagaaaattt ctaccttttc 2295481 cctcaatcct taccaattta aactcattaa ggagatactt tatcaccaac tttaaataat 2295541 aatggaataa gtgctaataa aataattcct acaaccaacg tagatattat taactccttc 2295601 catacaatca aattctttaa aaacatttga taaataacta atgagtttac tggaatgtta 2295661 agcaataagc ccgtaagaag tccaggtgca tactttttca ttacaacagt tgcgataaga 2295721 tgtggaaaaa tagcgttgat aaccatagaa cctagaaagc caatgaaaat ccattttgca 2295781 atatctgatt ctggcatata taaaaaacca aatgcagata aataagccaa catagttata 2295841 acaatgacag caaaatgaaa ttcatttgaa gttactggct tttgaaactt tgaagattgt 2295901 tgtgaccact caggtaacca aatagcttcc tcaatattat gaagtgtaat agcaaaacaa 2295961 aaaaatgcta cgaaataaac cacctatcat ttcctcctcg gtgccacaac caatatggtt 2296021 tggcaacatt atattacatt tgaggctgat tggatatggt gttaaaagag agaagaatct 2296081 gccttagtag ttgcttctta attatatgtg caataacgtg ttgttacgtg gcatgtcata 2296141 ttcaaatata ataactctaa agcaaacaaa gatacctata tagtttggca tcctcttttt 2296201 tagttcgagt ccctctattt attttgggca caaaatagac ataatttata ttgactcatt 2296261 atacccatca cataccatac cccttaaacc aatcaggatt aaaatgtttt aaaaaaggtg 2296321 atcaaagatt aagttatggt ctcttttatt ttatgtatgc tgtcttaatg caaaacaaca 2296381 ctggacacca ctaagtcaaa tgcatttcat ggtactatag tcaagacttg tccaagtcac 2296441 cattatcaaa atgaatttca tcaaacactt gaaacattta ttgaacgcgg ccaagtgtca 2296501 taacattaat aagaaaccaa cgagtgatga atcttttaat ctttcatttt acccgctggc 2296561 tcatatcaaa ggagctctaa ccaaatttta atagctgtcg cacctattaa ttgcgctaaa 2296621 acccattgca ggaattttgt atttactttt tgcccaactg atgcgccaat aggagaagct 2296681 attaaactag taatcataag aaccagagct ggtacaaaaa gaacctggcc cgtgattact 2296741 tttccaactg ttgcgccaat ggatgaaaga aatgtaatcg caagagatga agcgactgtg 2296801 actctaacag gaatatttaa aatcgataac ataatgggga ctaggataaa ggcgccgcca 2296861 gctcctaaaa tacctgatac gccaccaatg ataaacgcta aggaagaagc caaccattta 2296921 ttaaatatca cttccttatc ttcgctatgt tcttgtcctt tctgtccttt tttaggtata 2296981 aacattaaaa taactgctat aatagccaga attccgtata taaagttaat tcctttttca 2297041 gatatataat gagaaaagta actccccaat acactcccta aaaggatgct gcttcccatg 2297101 taaataatta atgttttatt tataagacca ctcttacgat aagcccaaac accgccgagt 2297161 gtcgcaaaaa aaacttgaat agcccctatc cctgaaactt catgggcagt taatgacatc 2297221 actcccacta aagaaggaat gtacaatagc attggataat taataactgc tccgccaata 2297281 ccaatcattc cggaaataaa ggcaccaata aaccctataa tgaaaagagt tgtgataaag 2297341 gcaatatcca ttttatttgc ctcctttcat aggaaaaggg tatctttcta ttcgataccc 2297401 tttcacattc attagccttt ttgaatccaa aatttcaata tatcgccctc gtccgtttgc 2297461 tctaaaaggt catgtccgcc tgatttagac caggctgtaa gatcattttt ggctccctta 2297521 tctgttgcat gcacttctaa tatttgacct gattccagtt cattcatcgc tttttttgtt 2297581 ctgacaattg gcattgggca tgccaagcct tttgcgtcta atactttatc tgatttcatg 2297641 ttcttctctc ctctttttag cagaaacttg tgttaccgta ttgcacagcg gtttgggcca 2297701 atctccattt cacgctgttt ttcttcatct gggctgattt tccccatgtt tgtttctcga 2297761 atctcttggt atgcatttgg ttgcggaggc aaatgatctg ttactaggtg tctaaattct 2297821 gtttcatccg caatgttcaa accatggttc tcgctaaata atgtacttag ttgtttacca 2297881 acacttccat tctcatttag ctcgtcaatg atcataaagt gtgccggtaa tacaattaaa 2297941 tcctttgata acgctttgta acggctataa agcgtttttc ttaaatctcc tacccaatct 2298001 tctgccatac cggctaagtc tggtctgccg attgaatcaa taaacaagat atcacctgaa 2298061 agaagatact ggtcatcgac aatgaaagaa gtggagccaa tcgtgtgccc cggagaataa 2298121 atcggttgaa ttttaatcgt tgtatttcca ataataatgt catttccttc ttccaacggc 2298181 tgataatcga attccacttc ttcagcatct ttaggcggta accagtaggt tgcttttgtt 2298241 ttttcagcaa tgactctgcc gcctgaaata tggtccgcgt gaagatgtgt atcaaatacg 2298301 tgagtaatcg ttgcaccctt ccccttcgca aaatctataa agaaattcac catacgtgtc 2298361 gcatcaataa ttgctgcttc accattggaa atgaccatgt atgacaagca gcctttaccg 2298421 attcgaacaa actgatacat ctcaccgcca tcttttaaat ccccgacttt taccggctct 2298481 aaatgttcgc tccatgcttt cattccaccc ttaaggtagg atacagaatg acctgcttca 2298541 gaaagcattt cggataccat gacggatgaa ccttcttttg cgcaaacgac cagcacttct 2298601 ttatcagaag gaattttctc caagatatct tctacgccat ctaaaagatc aaaataagga 2298661 acattcaaat ggtcaaagtc atgcccttct atcttccaat cactaaaatc attttcatta 2298721 cgcacatcca aaataaataa aggttctttg ttaaagattt ttttgtcact tcttttgggg 2298781 tcattgcctt tacggtcatg tttcaatacc tcctatatca aatcttttag cgggactaaa 2298841 acgttaagga tacatcagca tctttcgtaa aaccaaaaaa ggtaacagcc ccgcctactt 2298901 cgattccttc cataaaatca tcttttgtta aacccataac gtccatcgtt atttgacaac 2298961 caaatcatgc aactcccatt tcaatcagtt aagaatagaa ggcacatttg cgttcctaca 2299021 accttctgcg acatgctctt ttccttgtcg caatattaca gactttataa gcatcaaaca 2299081 gaccgctatt tgccgcaata atcgctactc ttgtactcat ctgttcatca tgctttttat 2299141 ttattcggtt ttacctgtcc aatcccgcat acccgggaca acattaataa cctttttaaa 2299201 accttgtttt ttcatggtgc gggccgccat ttcactcctt cttcccgaat ggcagataat 2299261 ataaatttca tcattttcgt ttaattcgtt agcgcgcttt tccacttcac caagagggat 2299321 atgcacaact cctgggatat gagctttttc atattcctct atctctcgaa catctaaaat 2299381 gttaagagac tcgtcactat ctactttctg tttgaaagct tctaatgaaa tctcaggaat 2299441 tgaagatgca ttttctgatg aatgctctcc tccttttcga agaaaatgac gaagtatttc 2299501 tccctctgct tcagtaccca gatattcatg gcctgtactt tttgcccatg cttccagatc 2299561 tgctgtagaa cctttatctg tcgcatgaat ttccaatact tcaccagctt ttaaatcctt 2299621 cattctcttc ttcgttttta cgataggcat tggacacgcc aaacctttag cgtctagtac 2299681 aatagttgct ttcatcattt tttcctcctt ttcttatata ggggtggggg tatacaaata 2299741 tacaaaaagt ttctcactgt aagttaacac catgtattca tacccccttt tatatttgtg 2299801 atgtttttaa atccttgttt cttcaatatt tttacttgcc tttaaacttc tcattccgct 2299861 tagcaatgag taaatgagta acattagata aataagttga cactgccttc ctcagcatct 2299921 gccaaataag ctgctacacc agcatagtca atatcatcta atagttcttt ttcctgtaaa 2299981 ccaagaagat ccattgtcat cgtacaagct acgagcttta ccccctgttc ttgagccatc 2300041 tcaatcaact gaggtaaagt aagtacatta tgctttttca tcacattttt aatcatttta 2300101 gggcccatac ctgcaaagtt cattttagat aaacccatct tatcagcacc acgaggcatc 2300161 atctttccaa acattttttc aagaaatcct tttttcactg gaatcagctc ttctttacgt 2300221 aaagcgttaa atccccaaaa agtatggaag atcgtcactt catgatcgta ggcagctgca 2300281 ccatttgcaa taatataggc tgccattgct ttatcataat ccccgctaaa taaaacaatt 2300341 gttgtgcgtt ttgtttgttc tgtcatgttt attctcctaa ctaattaccc ctgcgggtat 2300401 attaaagtca aaaaattttt tcgaaagatc tgcttttatt caactcttta aataccatag 2300461 ggggtataat ataacgcata taaaaattcg tcaaccttag gttgatgaat ttttatcggc 2300521 tctttaccaa taagtcgact gcttctttta ctaaattttg tgtgtcttcg cctttttcta 2300581 aactttcacg aacacaatgt tcaaggtttg tgctcacaat taaacccatc gctcgatcga 2300641 tcgcattacg ggaagctgct aattgggtca caacctctct acaatctttt ccttgttcca 2300701 tcatagtcaa tacaccttta atttgtcctt caatccgtcg taagcggttt ttaatctttt 2300761 gatcatactc catatatcaa tgaaatcctt tctttcattt atttttacat ttacatgttg 2300821 ccagttcata actgtttaca tggatacctt tgcgctttag aaaacgcact cctaaattta 2300881 attccacccg gtcacgagct attatgtgta ttttatcacg tggaatctct aaataaaaac 2300941 gttttagata cgcatatggg atgtttaaaa taatattatc cgaaaaattg gctacatcgt 2301001 tataatgacg aatatctaat attgtgatgt ccatagcctc taatttatct ttatggatac 2301061 aagagattcc ggttatagga taataacgtc tatacgttgc aatgataatc acaaaaataa 2301121 gcaggaatgc aataactaaa taattgatac tatttacacc accttattaa ctctttgttt 2301181 attcacaaaa caataatata cccccatagg tatatagtca agtgtgaaag ttactttctt 2301241 tgagctgata gattcatttc gatatccgcg gattgaaaaa atacttacat tcgataatgc 2301301 caattctgct aaaaggaact cgaataaagc aataagccga tttaatttta aatcggcttt 2301361 atttatcaat tacttaaaat tagcacaaga cacgctgctt ggatattaaa tggggtttca 2301421 ttagcatggt actggttccc catgtttcat gctggatgtg actttaatta ttctagaatt 2301481 ctccagaata tctgtgctaa tcttccgcag ccactgcatc tgctttggtt tcatgaactg 2301541 taccaaatgg atggttagga ggagcataaa tggagtaaag ttttaatggc gtatttcctg 2301601 tattaattac gttgtgccaa gtgccggcag ggacaacaat ggcagaatca tcatagacat 2301661 ttctttgaaa gttcaaatga tctttgctct ttcccatttt gacgatccca cgcccctgct 2301721 caatccgtaa gaactggtca acgttaggat ggatttccaa accaatgtct tctccaatac 2301781 caagactcat caaagtaact tgaaaatgct ttcctgtcca taaagcagta cggaacgtat 2301841 tgttttgttt tgtggctcta ttgatattta caacaaatgg ttttggtcca taatccttca 2301901 aaagaaggtt tctatcttca tatgaagagc gcaaatcggc acctctgtgt actttctcca 2301961 tctcatttgg aatagtccaa taaacagatc ttccatcatt atacatcggc acagtcacat 2302021 aataataaca ttgaggcgaa aaagggttat agtacatttt ttgatccccg caattataaa 2302081 tttttgtgat agtatcctat gcatttatta agggagtgtg ctaaatcaag aaaactcata 2302141 ttaaacacaa aaatgaatgt tcgatcaccg tttgattcat ggatgaataa tttatcaccg 2302201 accttgtaat cgttttctag atgttgaatt tcactagcct ttgttaacaa gacatcgaat 2302261 gacaccttta tatgatggat tatcaaaggt cgacgatcct aaatggcttt tgaacattta 2302321 catagcacaa caacagagta tacggaattc tgttgtttgt cccccctatc ccagctcttt 2302381 tagatttatc tctttggatg cgccttgatg gccagttttt cagcagcata gaatttatcc 2302441 cctcctgaat cgttatagca tatttcaacg ccgatagact tgcggttccc agtgccgttt 2302501 gtaccgtctc ctgtatgtgg gctcgctttt agtaaaccag tttatattct ttttgggcac 2302561 acaacagaaa caattttcca tatgaaaatc tcgtaatttt acacctcttt aacttgaagg 2302621 aggatttttg catatgtatt ttcatacccg tcaactacca tctcatccag catatattcc 2302681 tcatatgcat tttcccctat ttgcattcca tttctttcaa tgaactcaat gattctccgg 2302741 tacgcctctt cagtatttcc gcctatttca tatccaactg catacaggcc ttttggccgt 2302801 acatgataat ttatgttctc tgccccatct tttactttta tataaaagta actgtaattg 2302861 tagaagtctt tttctaagat ttgttcccgt gcaaagattc cgcctatcgg atatccttca 2302921 tctaattcat attgctgaac ttcatgaatg agttctgaaa tggctgccac atattttcgt 2302981 tctggtaagt ttaatgtttt tcggcttaac atgaatgttt cttcatttaa atattcaaaa 2303041 gaaattgagg aaaaatcagt ctcaagtgct tgttctgtaa gcgtcacttt tgtttgtaag 2303101 atcgtttgca actgcttaag ctcatttatt tttttatcaa tctcaataga cttttctttt 2303161 agaacatgca ggatcttgtc tggtgttttt ccttttatta gacactttat ttcttttaat 2303221 ggaaccccaa gctctttaaa tagactgatg acttgaaaag tctcaaattg atgataggaa 2303281 taatatctat acccattttc tttttttatt tccggcgaga aaagaccaat ctcatcataa 2303341 tgaaataaag tttgtttttt tacacggcag agcttcgaaa actcccctgt tgtgaaatac 2303401 ttcttaacat cttcgctcat aaaaacctcc ttgactatac ggtaaccata taccttatga 2303461 tttgattgta cttgaaaaaa gcttcaagcg aaaaggatag gtaaaaaggg ttcaattgag 2303521 taaaagggga attcagatga aaaaatcaat aaatgagcaa aaaacgatat tcattatact 2303581 attaagcaac atcttcgtag catttcttgg tatcggttta atcattccag ttatgccttc 2303641 ttttatgaaa atcatgcatt tatccggcag cacaatgggt tatcttgttg cggcttttgc 2303701 catttctcag ttaattactt caccttttgc aggtaggtgg gttgaccgtt tcgggagaaa 2303761 aaaaatgatt attctcgggt tgcttatatt cagtttatct gagttgattt tcggattagg 2303821 gacccatgtt tcaatatttt atttctcgag gatattgggt ggtgtaagtg cggcttttat 2303881 catgcccgcg gtaacagcat atgtagctga tattacaacc ctaaaggaaa ggtcaaaggc 2303941 tatggggtat gtttctgctg caattagcac cggctttatt attggacctg gtgcgggagg 2304001 atttattgcc ggctttggta tccgcatgcc gtttttcttc gcctccgcca tcgcgttaat 2304061 agcagctgtc acttccgttt ttatactaaa agagtcattg tcgatagaag aacgccatca 2304121 actctcatct catacaaagg aatcaaattt cattaaagac ttgaagagat ccattcatcc 2304181 tgtctatttc attgcattta ttatcgtctt tgtaatggct tttggtttat cagcttatga 2304241 aacggtattc agcttgtttt ctgatcataa atttggcttc acaccaaaag atattgcagc 2304301 cattattacg attagttcca ttgttgcggt agttattcaa gttttactat tcgggaaatt 2304361 ggtcaacaaa cttggagaga aaagaatgat tcagctgtgc ttaataaccg gtgcgatctt 2304421 ggctttcgtg tctactgtta tgtcaggatt tttaactgtt ttgcttgtaa cttgttttat 2304481 ttttctggcg ttcgatttgc tacgtccggc cttaaccgct catttatcca atatggccgg 2304541 taaccagcag ggtttcgtag caggcatgaa ctccacatac accagcctgg gaaatatatt 2304601 tggacctgct ctaggcggta tactatttga tcttaacatt cattatcctt tcctttttgc 2304661 aggtttcgtt atgattgtcg gccttggtct tacaatggtt tggaaagaaa aaaagaatga 2304721 tgctgcagct ttgaattaat tcattttcta taaagttaag tcatttggat gcagggaatg 2304781 cccctggtta ggcacaataa gaaaaggtac ttaatttgat aggctacatg ttgcttgacg 2304841 tgaatatagt ataagctgag ttttagcaat atcaggatac cgggataaga aaaaaggaga 2304901 atgtagtatg agtataaaca taaaagcagt aactgatgat aatcgtgctg caattcttga 2304961 tctacatgtc agccagaatc aattatcata tattgaatct acaaaagtat gtttagaaga 2305021 tgcaaaagaa tgtcactatt ataaacctgt cgggctttac tatgaaggag atctagtcgg 2305081 ttttgcaatg tatggattgt ttcccgagta tgatgaagat aataaaaacg gacgagtctg 2305141 gcttgaccga ttttttattg acgaacgcta tcagggaaaa ggattaggga agaaaatgct 2305201 taaagccctc attcagcacc ttgctgagtt atataaatgc aagagaattt atttaagtat 2305261 atttgaaaat aatattcatg ctatacgcct ttatcaaagg tttggttttc aatttaatgg 2305321 tgaactcgac tttaatggtg agaaggtaat ggtaaaagag ctatagatat ccaagcctcc 2305381 ttgtttgctg agaaacgttt gaacttcgat aatgattacc tacttaaact gcaagatcat 2305441 tgtttaaaaa agcctggatg aaaatttcat ctcaggcttt aagcatctta ttagtcaaaa 2305501 tctcatgtgt tttatccaga tgttattctt ttttccggac aatttctaaa taattaatat 2305561 gccggccaac tgtttcgtgc actttaaaaa tatacccatc ggcttctata acggacccaa 2305621 ctgcagcgtc tatttgttga gtcataaacc agccgcctat tgtatccact tcgtcacttg 2305681 ctaacgtcgt tcccaataaa tcatttacat cttcaatgag cactttcgaa tctaagatat 2305741 agtgattatc atttactttt ctaatattag gcacttcatc tttatcaaat tcatctctga 2305801 tttccccgac aatttcttca agaatatctt cagcagtgac taaacctgaa gtgccgccat 2305861 attcatccac aagaatagcg atatgtgttc gctctttttg catttttacc aatacatcat 2305921 gaattggaac ggattcaata acatggataa cagggttgat atgattttct aacttgaaat 2305981 cctcttttat cttctggtct gtgtcaatat aagctgacaa aaattcttta gcattgataa 2306041 aaccaatgat tgaatcttta tctccattta ggactgggta ccttgtatag ctctctgtct 2306101 taatgatctt aacaatagtt tcataagaat cctcactaga aatcgctacg atctctcttc 2306161 tcggaatcat aatttctttg gcgattcttt catcaaattc aaaaatatta tttacatatt 2306221 tcaactcatt ttgattgatt tcaccgctct tatagctttc agacagtaag atgcgcagtt 2306281 cttcttcaga atgagcaagt tcatgttctg atgcaggttt caaaccgaag agtcctacta 2306341 taaaccgggc tgaaccattt aaaaaccata taaaagggaa caggatgcgg taaaaccaaa 2306401 taattggctt tgcagtcaaa agagtgatgg tttccgcttt ttggatagcg agtgttttag 2306461 gagcaagctc tccaactaca acgtgcaaaa aagtcgccat cacaaaagca atcactaaga 2306521 tcaatacatg tgagactgtt tcacttacat gaaaatgagc aaataagggg tgcaaaatca 2306581 cttcaaaagt cgattctccg acccagccaa ttcccaacgc tgtaaccgtg atccctaatt 2306641 gacaagctga caaatattcg tccaaatgag taatgacctt tttggctgat atggcacctt 2306701 tttttccctc taatatgagt tggtcaattt ttgatgacct gatctttact atcgcaaatt 2306761 cagtcgcaac aaaaaatgct gttaagacaa ttaaaagagt aaagattata aggttaatgg 2306821 ttgtcaatga tttgccttac ctagtaaggc gtacacctcc gatgtaaata tttattgaat 2306881 aaacaaaaaa cagtatatat aacattataa gttcaaaaga acctaaaatc aactctgaat 2306941 gatgtaaata atcatctttt tccgtatgga gagtggttcc catagtcttc aactaacgat 2307001 tagtggcgtt ttaaggctta aaaaagaaag caaaataaaa acacacctga attttctggt 2307061 gtgtttcaat aatacccaac cgtcttgatt tatttaatgt ctttataaag attttctttt 2307121 aaaatttgaa tcaattcggc ctgttgcttt atatttttgc ggccatttct attaattgca 2307181 gcaagttcac agacaattcc agctgaaatg aaaaacaata aaccttcaaa cattttaaat 2307241 cccccactgt ctaagtgata gtcaaatttg ttttttcttt ttgcaatacc tgcttataat 2307301 cttccttacg ctgatatatg ttatttaaaa tgagtccaat aatgacaaac agtgttccta 2307361 ctatatcaaa agcagttatg ttatatcctt tgatcaccat gattaacaat gtagtaatgg 2307421 ggacaaagtt aataaataaa atcccattaa tggatgatag gattttaatg ccatagttcc 2307481 aactaaggag ggctatgata cctggtaaag taatcataaa taaaaaatca tacttaattg 2307541 ctgcaatcac tttaatactc ggtaccgaca cgtaaccttg cgcggtaagt atagctgtca 2307601 tgattcctgt tatagctgtg ccgaataaac atgtcaaagt tgaataacga agtgtggacc 2307661 actctcggaa tatctgtccc cccattgtgt agacaaccca ccctaaaaca ccaatgaata 2307721 taaagagtat cgagaataga tgatccccta atgaaaaaaa gaaacttata ttacctttgg 2307781 ttatgaccat cgaagccccc aaaaaggcaa tcaatatact gatcattgtg tattttttag 2307841 gtttcacatg tttatatccc catagaataa caattgaaag catcggcatg agtgcctcgg 2307901 caatggatgc tgtcataatt ccagacttcc ccatcaacct ttgacctaaa aaaataagaa 2307961 cattgtatat agtaaacgcc atcaccccaa ataaaatgat ccattttgct ttaccctcta 2308021 aatgaaatga tttctttcct tctctcacca ataataaaat cactaacata atcgttacca 2308081 caccgtagcg aataaatgaa aaataaaacg gatcaacaaa ttctaatgca tgatctgcaa 2308141 ctggaaacat cgcgccccaa gacatacttg ctactaaaca tgtaagggca ccaatgaata 2308201 attgaccttt tttcattgaa ttcccctcct tttctttaaa attacaatga gaattataaa 2308261 aagaagtaag catcaagtaa aatgaacaaa agtgatgaaa aacatcattg ataatgatac 2308321 tttaatgaag gggggatctt catggaactg cgagacttac aaattttcaa atgcgtagcc 2308381 catcacaaga gtattaccgg tgctgcaaaa gagttaaatt atgtacaatc taatgtaact 2308441 gcgcggatta agcaattaga gaatgagctc aaaacacctc ttttcaatcg ccataaaaaa 2308501 ggggtttcac taagcccaga gggccgaaaa atgattgaat acgttaacaa aattttgaaa 2308561 gatgttgaag aactggagca agtctttcta gatactgaaa taccgtctgg aatattaaaa 2308621 atcggtacag tggaaacagt gaggatactg ccgaccatca tagcttccta ttataaaaag 2308681 tatcctaatg tggatttatc attgcaggct ggtctaacag aggaacttat taaaaaggtc 2308741 atgaatcacg aattagacgg agcttttatt tcaggcccct tgaaacattc tattctggaa 2308801 cagtatgatg tttatactga aaaacttact cttgtaacca gtaacaaaac gtttaatata 2308861 gaggattttt caacgactcc gattcttgtt tttaaccagg ggtgcgggta tcggtctagg 2308921 cttgaacaat ggctcaaaga tgaaggtgtg ctcccaaaca gaatgatgga atttaacatc 2308981 ctagagacaa tcttaaatag tgttgcactt ggactcggta taacagtggt accggaatct 2309041 gctgttatgc atctagctgt acaaggtaag gtttattgcc acccattgcc tgagaaagac 2309101 agctgtatct caacaatttt tatacgccat aaagatgcgt acctgacaaa ttcaatgcgc 2309161 agcctcctaa agaccattgt tgaacataaa aatatgagta tggcttaaag tgatttttct 2309221 ctttctatat tctaacttct taaataaaag agaaggctca tctccacttc gctaccctta 2309281 ttcacgcaaa aaatagagca gtaaacatgt gagttactgc tctgcttcgt ttattcaccg 2309341 ttcatttgtt ttacaatgta ttcagcatca tttcctacgc cttgaagcaa cgctgaacct 2309401 cgcttatgct gccaaggcaa acctataaag tacaatcctt ctacaggtga aacacctcta 2309461 tgatgtatga ttcgaccttc ttgatccaaa acacctttta tatttatcca acataaggga 2309521 ttcctgaaac cagtagccca aataatattg tttacttcta atgtagatga atctttaaaa 2309581 atgatttcat tttgctttgc ggcaatgact ctttttttta agatgatctc cttctgtttt 2309641 attgcatgtt ttaattcatg cccaaatact ggatcacctt tcttttgaat gaatttgcct 2309701 actattgatg tatgacttgc atgtaaaact cctagtttat caaaccacca aaagatgctt 2309761 ctttttccga tcattaaagg gaaataaaca agtttattac tacaagctaa atatgtaact 2309821 ctttctttgg ataattcaac agctatttga gcaccactat tcccaccacc aactactagt 2309881 acatttccat atgccaattg ttttgaattc ttatattgtg atgagtgtag ttgattaata 2309941 ttatcggata aatcctttga tattgatgga atattagggg tatgaaaagg ccctgtagca 2310001 atgacaagat tcttcgtttg atattcttcc cgatttgttt ttattaagaa ataattcttt 2310061 atttttagga cacttattac ttctgtccgt aattggattg gaatttcaaa ttttttaaca 2310121 tacttcttta gataagcaac aatttcattt tttgaaggaa atccatgttt ttctccttca 2310181 agatgcattc caggcaaaga gctatacatt cgagaagtaa ataaaactaa tgagtcatac 2310241 cgatctttcc agctctcccc cacctcatga cttttatcca aaatgataaa cttttgatcg 2310301 gactgcttaa gataatatcc tattgagatc cctgcttgac cagccccgat tactatagtg 2310361 tcgtacacat tatcaccccg ccaatttcaa attgtcagta gacagaatct gcaaaatcct 2310421 agttgatctc ctcactataa agttagataa aaaatttaat ggtgatggtg gtcacgctgc 2310481 ttctccattt tgggctgaca aaggatcgca ttgtcgtggt tatgcgcttc ggtttccatt 2310541 tgaatggtta cgtgcgtaat gcctttatgc tcaagttcat gttcaatttt gcgtaaaata 2310601 ttttcacttt ctgaaatggt cagttgatcg tcaacaactg cgtggcaaga aagagcattc 2310661 aatccgcttg tgatagacca tatgtgtaaa tcatgaatgt tttgaattcc ctctgtccct 2310721 tcaattgtac gaatgatatc agagacatcg atattttctg gagttccttc cattaagatg 2310781 tgaatggaat ctttagtcac attgtaaccg cttcttagaa caagaatagc cacaatgata 2310841 ctagccaatg gatctgccca gccccatcca aagaagatga taagtatggc agctaaaatg 2310901 gcacctacag agccgagcat atcgcttatt acatgtaaat aagctcctct tatattcaga 2310961 ttattctttg tatctccgcc actcatcata atccaagcga ccaatagatt cacaactaac 2311021 ccgatgatac taattgtaag catgccggtt gttgctactt ttggtggatt agagaagcgt 2311081 tcgattgctt cataaatgat ataaagagaa ataagaatta aggcagcacc gtttatcaca 2311141 gctgcaagaa tctcaaatcg tttatagccg aatgtcttat tgtgatttgc ctttttttca 2311201 gctaatgtaa aagcaatcag ggcaaccatt aatgaaattg aatcactcag catatggcct 2311261 gcatcagata aaagcgccag gctatttgtt aaaaatccac ctatagcttc tataatcata 2311321 taacctgtaa tcatgataaa agagatcaat aaaacctttt tatttgctcc ttcattatga 2311381 ttgtgaccca taaaaaactc ctccttacct aaagttttta atacatatgt atttattatt 2311441 tcaaatctgt tatgaagcat tctaacatga tacaaataat atttatatat gagcatgtgt 2311501 tcatatataa atatatctgc tctttactga aatgtcaaaa tatttttata gaaatccaca 2311561 atacctcctt aattattctt ttataaacat aaaaaagcgg agcaaacaca tggtttgctc 2311621 cgctacccta gtttctctat ccttttcttc aatcaagcat ttgagggtag tattcaacta 2311681 caatttacct gttaaaaatt gggcctcacc aagtccaaaa ctccagtcag cattatcatt 2311741 ttcaacaata gatacaatta aatcagttga tgcgatacca cactcagatt ccagtctttc 2311801 agctaacagc ctgtaaaatt tttgtttctt ctcttccggt cgggatttac ttgtaactga 2311861 aagaacaaca agatttttag ttcggttaaa tcctaaccca gtatcctcaa taatcatatg 2311921 attttctgga tgttcatgaa caatttgata acggtcttgt tgaggcacat caaaagcctc 2311981 tactacaaca ttgtgagcga catctaaaag ttttttcaaa cttgattgat ctcgcccttc 2312041 tattaagtca aaacgaagta atggcataaa atcccctcct tctactacaa cagtcttttt 2312101 aatttcattc gttaatgtgt cagctatttc caagcagctg ctacatttag aaaataaagt 2312161 aatttcccaa taaccccttc attctggtgt tagtcaagcc tatgttatga tgtgtatttc 2312221 cataggcaat atacagaatc aacttcgagt aattaaccat tttttgaaat agctttatca 2312281 cttactttag aaatcattta ttcttctaag ctttagttta catgaagctc tgctatcata 2312341 tataattcaa aattaagatg gaagacatct caaaatcaga tatcaactat ggaggactag 2312401 atgaatattc agttgttaca ggtttttctc actactgctc gtgaaggcag tatttccaag 2312461 gctgctctga ctttaaatta tgcacaatcg aatgtaacga ataagataca acaactagaa 2312521 aacgatttac agacaaaatt attctatcgt catagtcgag gaatcacact tactccccca 2312581 gggcaaattc ttgtttctta ctcagagaaa attctacata ctattgaaga agctagagca 2312641 gccatgggcg aatcatccgc gccttctggg ccactgcgta taggatcaat ggaaacaaca 2312701 gctgcagttt ggcttcctca actccttgca cattataata acctctatcc aaatgttgat 2312761 ttgaacctag taaccggccc tacggaacaa caaatacaag cagttttaca ttatgagtta 2312821 aacggcgctt ttatttcagg gcctattgaa caccctgatt tagttcaaga aaaggtattg 2312881 gatgaagaga tggttcttgt tacaagtgct tcacaccctg tgatttcttc cattcaggat 2312941 gttcaaacac aaacaatgct tgtattccgt aaaggatgct catacagagc aaagctcaat 2313001 catatcctgc aagaagaagg tttattacct ataaaattaa tggaatttgg catacttgaa 2313061 gcgatcattg gctgtgtaag cgccggcttg gggatttcac tgctgcctcg ttcaatcatt 2313121 gcttcgcatg aaaaagaagg ccgcatccgc agccacacta tctctgacaa atattctttt 2313181 gtatcaacta tgtttataag gcggaaagac actttaatta cccctgcttt atctgctttt 2313241 ttaacgcata tgagggatca ttttcagata aagaggccag atcaatcgta aataaatgga 2313301 tggaaggcat gcttcgcctc aaaatacccc tgatcagttg tctgatataa aaatataggc 2313361 gcatctcaat gtttgtatag agcaaaaaag caaacttcgg tatgtagttt gctttttctt 2313421 cgtgattttg cactctgaat cgtgaaacct agtcgatatt aggatgtaga ttttcctcat 2313481 tcaaagaatt ttgaacgaag gtcattgccc tagacacttg gttgcgtctt gaagttaaag 2313541 gctgactatt tcctaaagcg tcaatcgctc tcacaactat taaatattca cctacagatt 2313601 tcgggtgaca acgggaagat tgatattttc ggttggacag gggcagaaca tccaattgta 2313661 acagttgaag tatccactga tggaggagat cctgcagatc tgagtgatat tgctgttgat 2313721 tgatcaactt gtttttgttc ggaatatact cagtatatag ccgcatattc ctcctgcaat 2313781 agctggaatg agccacccca gccctatgtt atacatagga agaatctgag tgaaaatacg 2313841 attcacaact tcaattttta ttccagccgc cttcaaaccg tcaaataggc tgatgatgaa 2313901 tgcgaataat aaactgcctt gatacacttc tgtcttccct ttaaatacag aatgcaaaaa 2313961 cgttaaaaat attaaggaaa tcgcgatagg atacatcgtc agtaagacag gcattgacac 2314021 cttaatgagc tgggttaatc ctatatttgc gacaagcgta ctaaacactg ataaaacgac 2314081 agcaattttt ttataagaaa tgttcggaaa taattcatga aaaaatgaag aacacgctgt 2314141 gatcagcccg acacttgtcg tcagacacgc cactgtaatc attaagccca ataagattga 2314201 accataagat ccaaaataat aggatgaaac cttagccaaa acctctgctc cattttctaa 2314261 aatccccagt tcttcaacgc tggaagcccc catataggaa agggctgtat acataactgc 2314321 taagagtaca gctgcaatcg cggctgcttt tgcacaaaca actatcagct gttttttggt 2314381 agaagctcct tgttctttca atgcattcac gatgataatt ccaaaaacaa atgctacaag 2314441 ggcatccaga gtgaggtatc cttcctgaaa tcctttaaaa aacgcttgtg atgtgtaccc 2314501 ttttgatggt gcttgaatgg ttccaattgg gcgaataaga gctacggcta caagcaatcc 2314561 gataaatgtc agcttaattg gcgtcaaaaa tttaccaact atatcaatga tttttgaagg 2314621 attgagtgat aacaagcatg ccaatgcgaa aaataatatt gtaaatatga tcaatgagac 2314681 agggcttgca tcatttgata aaaaaggttt taccccaatt tcaaacgata cgtttcctga 2314741 tctcgggata gcgaaaaaag gcccgattgc caaatagaga atcgtcgtaa atacaatgcc 2314801 aaacaccggg tgaacacggc tggctaacga ctgtaagttt tgtttacccg aaaaaacaaa 2314861 tgctgttata gccagtaatg gcaatccaac tccggtcact aagaaacctg cattagcgac 2314921 ccatacattt ttcccggcca attgaccaag cataggcgga aaaatgagat ttcctgctcc 2314981 aaaaaacaat gcaaatagca ttaatcctat aatgatgata taggaagcag acactttttt 2315041 tgacattata tatcctccga ttaaagtaga cacttcttga atagccagga aacattacag 2315101 atgctatttg cactggcaca gtgttgattc caaaataagc ttgtgtcagt tttatatatt 2315161 tttatcaagt taaataaaag catgatcatt ttgatcgttt ccgatatcgg ttaaaaaacc 2315221 aattgcacca aaaccatata aacaacggtt ccccccgcta tggaaagaag catatttttc 2315281 ttccacaagt gaagcagtac aacagcagct gctccaacca attcaggaat gccatgactt 2315341 ccagaaagta gactcacatc tttcaaacaa taaatgacta aaagcccgat taccgctgat 2315401 ggcagcactt taccaagata ctgtacatat ttcggtgtcg gtttgccaga cgggaaaatc 2315461 atgaatggaa ggaaccgtgt cagcattgtt ccaagcacga ccattgcgat ggtgatcatt 2315521 tgctgcgtca tagtcatcgt catacggaaa cctcagcttt ctccaatggt tttctcagaa 2315581 cagtcagtac ccctaaaatg gcgagcatag caggaataat aaattggttt ccgccaaaaa 2315641 ggataagact ggctactgaa agtccaagtc ccgtgagagc actgtaatgc tttttctctt 2315701 tcatccattg ttctatgaat atcacaataa acagagcagt catcacaaaa tcaagccctt 2315761 cggtattaaa cttcacgtac gacccaaaaa tacctcctat cgctgccccc gcgacccaat 2315821 ataaatgatt aagcagtgtc acaaaaaaca taaaccagcc cttatcaaca ttcgccggaa 2315881 cattagcggt ataattgata gaaaatgatt catcgcacat tccgaaaatc agataaagct 2315941 ttttctttcc agtccccctg tacttatcca acatggaaat tccataaaac aaatgccggg 2316001 cattgaccat taacgtcaaa aaaagagcat tcatagggtt gaacgcacca agtaaaaaat 2316061 tcgctgcaac aaactccatt gagcccgcaa atatcataaa actcatgatg attggataga 2316121 ttgcgctaaa tcccaaagaa tgcataaaga tcccataagc tatccccaaa aataaaaacc 2316181 ccgcaaaaat cggaatggta tatgggaatg cagaacgaaa tgcagcccat atttgacttc 2316241 tcttattcat atgagtgttt atagcaggag agcttaaatg taacgattct ttatttttat 2316301 tcaaatcaac aacctcctac atttcatcaa ttggcacact gacagttctt ttttctgtac 2316361 tcatgactat gcttgtgtca actccactaa tagcagggtt ctgcattaat gaatcaatga 2316421 taaaattccg ataactctcc atgtccttcg ccacaatctt aagcatatag tcatggcttc 2316481 ctgtaagtgt gtagcattct tgaacctgtg ggaatttgtt tatatcctct aaaaatgaat 2316541 gaattgtctc cctatttaag ggtgataagt tgatgagagc tagtgctgtg acttcgattc 2316601 caagtttttt ctcatcaaca atagtcgtaa actttttaat tatacctgct tctactaggt 2316661 tctttgttct tgcaaggcaa gctgatggtg aaagcccaat tttcttagat aaatttaaat 2316721 ttgatattga agcatcttcc tgcaaatctc ttaagatggc cttatcagtt tcgtcaagca 2316781 taatacccat ttcacaaccc ccaatacaac ttaacagaat tatatttcat acaatttaaa 2316841 taataacgaa tttttattcg ttaatcaaat attatttaaa tttaaatcct tttaaagtat 2316901 tattcacaga ataaaattat cctcgcgatt aactcataat gaaattaact tacatcagaa 2316961 agaagtcatg ggagagttat gtacttgtgt gacttgatac caacatcata agaaacttat 2317021 cagaagccaa aaagttattg cggtctcacc gaaaattgaa tttgcggtgc cctattgcct 2317081 ttttccgcga acgaaaattg ttaaaattcg caaaacagaa agtctactct attattattt 2317141 taaattcgtc ctttagttct tcttgagcct cttgtataac ttctaataca tcgtcagcgt 2317201 atgaacctaa aaatgtattg ctgaactcaa aatttttcaa gactaaagtg agcggcaaat 2317261 ccacccaccc tgtcaggcaa tcccataaag cgtctaaatt tctcccatag tagtctggga 2317321 agtctagttt atcttttaaa tcatcatgta aaacttctat attttcaaag tctcttccat 2317381 ctattattat ttttctcatt agaaactatg ccctccatta ttttatctta acaaacgttt 2317441 actatgtaac agctgtttgt ccaaatgagg ctgaaaacaa ataaaaaaca ccgataggat 2317501 gaaactattg gtgtttgcaa gacatcttca tacccggtag gcataaataa tgctaaactt 2317561 tgtttttaaa aagctatcat atcaaatttt tatgttacag cttttactat cgtttaatct 2317621 aattgaggag taaaacaaga tatgtttgaa aatcacatat cccctaaaaa ttaaaaacta 2317681 atcggcagtt cttcgagtgc tctcatcaga aaattccctt tccatttcat ttgtttcttt 2317741 tcgcctttta actgtatatt tggacagcgg cgtaataagg tggaaatcgc aatctttgct 2317801 tctaagcggg ctagctgtgc accaagacaa aaatgattgc catggccaaa agcaatatgg 2317861 cggttgttct ttctttcaat atcaaatatg tcggcatttg gaaatatctt ttcatcacgg 2317921 tttgctgatg ctaaagaaat gatgatcaca tctttccgtt taatctcctg cccatgcagt 2317981 ataaacggtt cagccgtcca gcgaattgtc gttagctcaa cagggctgtg aaaccgcaat 2318041 gcttcttcta tggctgaatt catcaagtcc ggctgctggc ggagcttttc tagttgatca 2318101 tggtgacaca tcagagcata tgtcatattg gtgattaagt ttacggttgt ttcatgacct 2318161 gcaacgataa gcagcataat catcgagtac aattcttctg tacttaattg tgtgccttca 2318221 ctttccgctt gaattaatgc actgattaaa tctcctgcag gttctctcct ttttttgcga 2318281 actaaggatt ccagatattc aacaaactcc cctaacaagt ggtcattctc ctgaagtctt 2318341 tcaggggcat ctgaaaaatc aataattgct tgcgaccata ctctgaattt ttgacgatct 2318401 tccaagggaa tgccgagcat ttcacttatc acgataatcg gcaatggaaa cgcataatcg 2318461 tctactaggt tcatgaattt gttgggctgc actttatcca ataaagaatc tgcgatatgc 2318521 tggattttgt cttccaactg caaaatcatc cgatgcgtaa atgctttttg aacaagagtt 2318581 cgcaagcggt tgtgatcagg gggatctgaa ttaagcatat gttttgttaa agtctcttca 2318641 ttcttcaata gagcaggacg tttttctttt gcggtaaata cattttcata gtttttcttt 2318701 aatttttcat tctttaataa atgtattgca tcatcatatc tcgatatgag ccagcctttc 2318761 cccagagctc ctaaagataa tgggtagaga gcctgtgatt ttcgcaattc tttataaaat 2318821 tcatacgctt catctttaaa tgctctcgaa gacaattgac tttccgtcaa aatggttaca 2318881 ctcttttttt cttttgaaga cattcattcg acctccatct ttgaaaggtt atgataatct 2318941 ttaaatataa aatcaggacg atttgtaaaa tgatccattg agatcagtat tcatgataag 2319001 ggccaaaatg ccgtccccgc attttgaaat aaaagatatg agacagtcat taatcatttt 2319061 gctgcctaaa ctctttccct gataaaatgg cgaaactcct aatacttcta tgccggctct 2319121 tttaaggatt tggaaaattt tttagcccca ttttgattaa tgttatcccc cctgctgcta 2319181 tataatcgat caagtttaat gtcgggttta tcacgatgtt ttaatagagc ggcaacaacc 2319241 atttcaccat tctgaatgcc aacaaaaaag aaatgctttt taaaatatgc tcttgtcagt 2319301 actttatgca tttcaaaaat aaatgaatga tctttttttc gcgttttacg agtaaatcca 2319361 taaaaggata ttgattgaaa gattgatgga atagctttgc cactttgctt acttcatctg 2319421 ctcttgcttg tcgataaaga aacattgatg cacctcctct gagcagtaaa gcaggaaatc 2319481 gaattaaagc gcccttccta ttggaaaggc gcctgccgtt ttactgtgcc aaaatgtttt 2319541 tcatcagtga gtttttataa aatcatttat taattgatca gttgtcaata ttgtggcaaa 2319601 ttcatcatgc aatgtagcta gagatatatt atgaatagtc gccgcatcat aatatgtatc 2319661 attttggtct ctcattccga aggctgctgt tgcatctgaa atcaggtatg tatcaaaccc 2319721 taaattacca ctcattcttg tggtggttga tacacagtga ggcgtggtta aaccagttat 2319781 gactacagtg gttatttcat ttaattttaa gaattcttct aaattcgtac caataaagct 2319841 gctatttact gtcttggtta taatgacttc ttcatccata ggcttaacta tttcctttat 2319901 tgcaaaccct tcattctttg gatggaataa agaatgaggt ttatcagaag tgtgttgtat 2319961 gtatatgact gtccatcctt tttctctcca taattctagt attttactaa tgttttcttc 2320021 cgcctttacg ttattccgtt ccccccattt tttatcatcg aaggcttttt gtacatccac 2320081 aatgattaaa gctttctttt cttccacaag ataccctcct acgtagaatt tctatttatt 2320141 actacattct aaatacaaat tttacttttg tacaattgtt taatgatgaa tttcaaatga 2320201 gcgccttctt tattggaaaa tgcgttctat actgcaactg tgcccaagcc gttaaccttc 2320261 aaatctaatc tgagaatcac tggctctaca gagaataata aaaaacactc taataacgag 2320321 tgctgaaatg aaaaactatt gatttagaag ccatttgata cgctcagctg aaatgatgta 2320381 gtggagtatt ataagacata aaaagacaat actaactggt tttaaataac taaaataaag 2320441 cgctgcaaca gccattgcaa agatcaataa ttcaataact aaccttgtta ctccgtttac 2320501 agctattaca gtttgtccgc ttcgactagg atcatgaggt actgcaaata cagaccagac 2320561 aatcataact gcaataggta aaaccaaagt taaaacatat ttaaaataac cattaaagct 2320621 tatccaagca tacaccccta aggagattag tgcagcaatt tcaagggtga atcttaaaag 2320681 taaattagtc tgattcagtt tttccaactc ctctataaaa aacacccccg caggagatgc 2320741 tctttctctg ctttatttca gcgtataaaa acttttctgt tcttcctctt tagattctat 2320801 tgtagttttc ggcgagatta cctctacttt tgaagagatg ataccgactg ctgctgttac 2320861 caatgctccg ataatagaac gatgataagt ataatgaaat atgacaactt ttcccctcct 2320921 attcagttaa ttatccaaat aatcaggaag ttgtctacaa tttgcagaat ttgtcgaacg 2320981 aagtaaagat tatacctggg aggctttact cattgtatga attacagtaa ataaattgcc 2321041 ttcccttttg agaagacgtt ccaactcagc tagactcttc caataggctt ccttttggcg 2321101 cagctgcttt tattcaaaaa ttgagcaaca cctgaatgtt tcattggaat ttctgaacca 2321161 tcgatcgctg ctgaatttgt tgcaaatgca tacgtaggag tagtcgaatg gtggttgaaa 2321221 aatgaaatgc cttccccacc tcgagtgatg gcagaaaaag cgggggtttt gttagagagg 2321281 aatctataga tatgtgtatc gaagatttga cagcattaaa aattatactt acatcgttgg 2321341 gaacaggcca acaataaagc ggaagaacgt tgtcatttga agtggtttgg aataaaaatg 2321401 attcgaatat gttcttatca ttgtaaacga acaaaaaaag aacatgtttt gaaaaaagat 2321461 tgatcaaaac atcttcttat atgttgtcat agcgtaactt tttataaaaa ggttaattac 2321521 attttcgggg cttccaaacc aaattttgcc cattcttctt ttgctggacc ataaatacct 2321581 ggaacagtta aacctgcttg tctcataaga acagtcattt gtccccgatg gtggttttga 2321641 tgttgaatta aaaacatcaa aagtgaaccg ttaggcattt gttgtccaat aaagttgata 2321701 cgttcttgaa gtgtatggtc agtccattgg gtttttaatg cctgtacaaa tgcattactg 2321761 gcttgatgat agctgtcagc tataaactga gcagaagttg gaacaggata atcttcagct 2321821 ggggcttgga acgttaagtc tgtgtttgag gtaatgatgc caatggcagc aacagtatgc 2321881 caagcaatac ggcctagagt ccaattttgt gaagttattt cttgtttaag tgattcatca 2321941 gtcagactat ttaatagttt ctgtgtagca tctgcttcga actcccaaga tttcaaaaaa 2322001 tggtctaagg tttgaaacac aaaaatcctc cttttcattc ttttgttttt tcaatgtgct 2322061 tataggttaa ttataatgcc tcctttcgtt aaaaagaaca aaaatttcgg acaagaataa 2322121 tcatagtaaa atgcgtagac attcttaaac gtaacgattt acgcatcttt ttacaaacat 2322181 ctgactactt ggtctccatt gtcagcgaga atcaaatatc atatgaagac aatcctatat 2322241 tcttatcact ttactgagca ataaatacct tccgtatact tagtaatacc ttcatcgtaa 2322301 tcaggatact tatatgcaag accttctgat acagcttttg aatactttct aaataatgca 2322361 tagcaagtaa ataaagactt ccacatttcc tgatacccat tcacagaata tgtagacatg 2322421 agttcctccc attctttatt tgaaaggtac cgcttcataa atttatagtt cttccccata 2322481 ctaaatgaat accctttctg agatgcgata tgccaggcca tcattctcaa taaattagga 2322541 cgtacaattt catttaaatg gtcaatggca aaaaggattt catttcttgc tagtcctttt 2322601 actacgtaag tcgaaaccat ccagaactca ttacagcaat catcaaattc ccttgcagtc 2322661 ggccttttta tccagtattg gcgatcattt ggggtcactt tatagttgat gaacgaatcc 2322721 ttatcaagca ataccttaac caaaccatcg ttattagcaa aataatcttc tgcttcacga 2322781 attggaataa gggttagatc taatttgttg ccatcctcaa aaagaataat gtatgaaaac 2322841 caattaccta attcgggagg aaaaagctcc atatcttctg gtttttgcat cataatgcgc 2322901 ttcccaaaga tttcgagcca ctgatcattt tctttaaaag attctacatc agttacaaaa 2322961 tacgagatgt cataatcttg gaagttgtca ggagggatat ttctgtttgt acgtgaccct 2323021 tccaaagtga ccaatcggat tctctcatcg ttcaaagcaa agtccaaaaa aatgtccatc 2323081 atttcctgct cacttcgcat tacatgttcc tccgtttcag ccttaatatc taactgtaaa 2323141 acgtcttata gattttttta ctcttgaatg tgatgtattc ttctaagctt tattttacat 2323201 gatgttctcc tatatatcat tcaatattaa gatgcaagac atctcaaaat cagatatcaa 2323261 ctatgacgga ctacatgaat attcagtttt ttgtagagcc gccatgggac gacactatct 2323321 ttgacacact ttaatccccc ctgctttatc gacatgttaa ctggtatgag agattgacaa 2323381 aaagaaggaa aacgatatat ttaagcgaat acgagttttt gagtaaattt taaaatgaca 2323441 cttttttcaa aaatcatgtc ttaacgggag gattcggtat gaatgaattt atgaaaaagt 2323501 tttctttaac aaaaccgatt attcaagctc caatggctgg cggtattaca aagccccgac 2323561 ttgcatctgc agtttcgaat caaggtgctc ttggcagctt agcatcgggg tatcttacgc 2323621 cagacctcct agaacaacaa ataaaagaaa tatttgagct gacagacgct ccttttcaaa 2323681 ttaatgtgtt tgttccgcta ggtctagaga tgccaccaaa agatcagatt aaaaagtgga 2323741 aagaaaacat accgttagct aatcaagtaa atcaattcac atctgtacaa gaagagtggg 2323801 atgacttcta tcaaaaaatt gatctaattt taaaatacaa ggttaaggct tgctcattca 2323861 cttttgatct gccgcctgaa gacgcagtaa aggagctaaa aaccgctgga tgctgtttaa 2323921 taggaaccgc ttcaacagta gaagaagcat tgttaatgga agaacgggga atggatatag 2323981 tagtccttca aggaagtgaa gccggtggac atcgcggagc attcttacct tccaaaggtg 2324041 aatctgccgt aggtttaatg gctctgattc cacaagcagc agatgcactg agcgtacctg 2324101 tcatagctgc tgggggaatg atagaccaca gaggagtaaa agcagcttta accctcggag 2324161 cccaaggcgt tcaaatcggt tctgcctttt taatttgtca cgagagtaac gcacatccag 2324221 tgcataaaca gaaaatacta gaagcaaacg aagcagatac aaagcttacg acattatttt 2324281 caggtaaaga ggccagagga atcgtaaata aatggatgga agaaaatgaa cagtttgaga 2324341 cacaaaccct tccgtaccct tatcaaaata cactaacgaa ggcaatgaga cagaaggctt 2324401 cacttcaaaa taaccatgat cagatgtctt tatgggcagg tcaagggata cggtcattga 2324461 ctgaggaaat ttcggttaag cagcttttaa atcagctttg ccaagaggat ataaaaatat 2324521 aggcgcacct cattgataga gcaaaaagca aactttgaca ggcagtttgc tttttttttc 2324581 gtaatttcat ccactgactc tggaaatcta aatactccta cattttcaaa gctaatttga 2324641 atcgggttat caatcatcac attgatacga tgcgatcttg ataatttcac cacaaccaca 2324701 atacattacc aacatttcga tcttatctcc ccttctcaag ttttgctccc tattcgaata 2324761 atcgatagct cccatattaa atttgaatag taaaatggtt ctttttcgtt tgattcagat 2324821 gatataaagt catatgataa aaaaagaatg agacagaaag cgtgagaagt gatgaaaata 2324881 ggattttttg attcaggaat tggtggcatg actgtattgt atgaggccat aaaagttctt 2324941 ccttatgaag attacatttt ttatgcagat acgttaaacg ttccatacgg tgaaaaatca 2325001 aagggtaaag ttaaagaata tattttcaat gcagctgaat ttctggccag tcaaaatatc 2325061 aaagctcttg ttattgcgtg taatacagct actagcattg cgatagagga tcttcggaga 2325121 aacttcgact ttccgataat cggaatcgaa cccgctgtaa agcctgctat aaataaatgt 2325181 acagaggaaa gaaaaagagt tctggtagtt gctactaatt tgacgcttaa agaagagaaa 2325241 tttcataatc tagttaaaga aattgatcac catgaccttg ttgattgctt agctcttcca 2325301 ggactagttg aatttgctga gaactttgat tttagtgaag acaaaatcat taaatatcta 2325361 aagaacgaac tatcttcttt tgatctgaaa caatatggaa cgattgtgtt aggatgcact 2325421 cattttccgt ttttcaaaaa cagttttgaa aaactgtttg ggataaaagt tgatatgatt 2325481 tcaggcagtg tcggtactgc aaaacagttg aaaaaagttc ttgcagatcg taaccagctt 2325541 ggtaaaggat cgggctcaat cacctttttc aattctggcc ataaaattgt ggaccaagaa 2325601 gtcatatcaa agtacaaaag attgtttgaa atattagatg aaactcaaag gagtcatgtt 2325661 ggacattgaa tgtaaatgaa aaagacaatc tcctgaagag aaacatgaac taagaagcgg 2325721 gcttaaaaag cccacttttt ttctaacaaa caattgagtt atacacacat atctgattac 2325781 agtgttttct ctctttcccc tcttatttct cccccctctc tatagctttt ctatttcaat 2325841 aaaacacaag tctcgattga aaagttatcg taacatttac acttcacagg agatttttca 2325901 cgattgcgaa tcgaccgttt gccagatgca caaagtcata atgtgtaaat tctgtatcta 2325961 tgtgcatgtt tattatggaa ttattttcat aatgttttat aatacaagat gatagcgttt 2326021 tctaattata atgatagggg gaaataatga tgatgaaaaa aggtctgctt gcgggtgcgc 2326081 ttacggcaac cgtgcttttt ggcacatgtg cagtagatgt accgggtatt attagtccaa 2326141 aaaccgcaga agctgcatca cagctaactg atggaatcgg cgggagggct tacttgaaca 2326201 gtaatggtgc cattcttgtt acgaaaatcc agcttcctag ctccactcag gtttcaaatg 2326261 ggacagccta catctactct ggttttagcg gaggcacaga atccgatatc gggtttcagt 2326321 acagtgataa atataatgta tggaaaccat atatgaaagt cggttcaaaa ggacaggatc 2326381 aggttcagta cctcgaagga ggaagccaat tcacgaatac gaaaggcttc cgtcccggca 2326441 gcaccgtaca acttaccatc tacaaaaacc ttaacggcaa tacccgcgct acatactggg 2326501 gcacgaacaa tgccggatac aacggccgtc tcatttcaga aatcagcaaa acaaatgtcg 2326561 gctccatctc aaaatggaaa gcgctcgcta cagttgcaac aacagggtca cgccaatcta 2326621 tcaaatcaaa cttttcaaca tcttttacaa acatcaccat cgacaacaaa gcaataacac 2326681 ctgtaattga tacacaagac ttcgctaaag taacagtctc aggcaacagt gtcagtttat 2326741 ccgttgtcaa aaattaaaac atgttaaaca tacaatgcgt taggctattg agaagctctc 2326801 gatagtctta aagggggctt aacatgcccc ttttttcatt tcaatttaac tttcagttag 2326861 cttcggtaca tgccgtctat ccccgtcttt tatctgggtg aagtaagggc agctcgcccc 2326921 ttctgaacct gttccatttg ctcaacgcaa aaggtgtgca tcactgtctt aaaaatgtta 2326981 aaacaaatag cagatggtgc actttatttt tagatgaggc atgcttacgc tcgatatgca 2327041 agtcaaatga ttaagggtct gcaagagaga gaagttttgg gtgtactttc ataaaagagg 2327101 gatggcttca tatagctcga ttgcatcagg aagattagcc aacgattggc cgagaacaac 2327161 acatcacttt gaaacggatt cattccaaaa tcataagtat gatccaataa ctaataaaga 2327221 tcagttagca gtccagcctt aaaaatattt ttacatcaat taaactagca tcactatcga 2327281 ataagctcga tctgcatatc atgtactatc ctcttttaag gaaggtgatg ttatgaggtc 2327341 atttccatta atcgtagttc tattcatcct attaatcatc gttgggacat ctttctttgg 2327401 tggctattaa gaacacacct tacctcatat ccatcagacg ccataagaaa tctttatggc 2327461 gtctgttttt tattagattt aaacaaaacc attaaagtgg gccatgcaaa cacacctatg 2327521 gagattactg ccacgacttc tttgtgaggg aattattctt ccctttatgg actattgtcg 2327581 atcaaaagag aaagttgaaa tgcattttta tggtgagatg aatcgaggct tagacatata 2327641 aaaaaccgca aagctttctt gaagaagctt tgcggttttt gggtctcttc tttgcttcat 2327701 ataagccaat agatttcaag cgtaatccac tgccatacat ccaatgattt tttattttga 2327761 aataggtttc ttctactctt catgtgagat gactcaaggt atgccacgtc acaataatat 2327821 ggcggatact gaatggtctc aatcagtttt ttccccattc tatcaattct ccacagaaaa 2327881 aatggctatg gcagaacaac tttcatagag taatcatcat ttaatgagcc atcatctcat 2327941 gggcaatatc gtgtccatcc atttttgacg ggtagtaagt aggccagttt ttgacttcat 2328001 caagtaaagc ttcacggtcg tccccccaat agagatggta atgactagct ttagtcgggt 2328061 aaatactatg atcactaaac tgaatatact gaggcagccc ttctgctttt ttagctagtt 2328121 tgaatatgta tcttacccct ctattgcccg catcataggt tagaatttcg tatccgtcat 2328181 acgtatactt accagaatat tcttttccat ttttgaagaa cgttacagta tctttctgga 2328241 ttacaatacg gtcaacatct gtttgatagc cttttttata atactcttta tattcttcag 2328301 ctgtcttgcc gccttcgtgt tctgatttat atgaaaacac ttcgtcaaga gtaccatctt 2328361 gcaggtatgg atatacagat tgccaatctc cttcccaatc agaaagtaag cgatccttta 2328421 cttggctgtt tttaaaatag ccttcatata ttttttctgt ttcttcatca tgcgcatgac 2328481 tatgatcgtg agaatgttcg tgtgtatgac tgtcagatgt ttgctcttgc gttttggaag 2328541 agtcttcttc aactgctgag gatgatgttg tttgattaga ctcacctgca gaagaaccgg 2328601 aagtctgaca tcctgccaaa actagtaatg aaccaatcgt taatatgcct agccgttttg 2328661 aaaataaaat gttcattcca acactccttt tttattaaat cgaaaacatt acgatttatt 2328721 atacatacat ctcttgcaaa catcaaagga aaaatgctct tcatgcggat ggcctatttt 2328781 aaaggaataa ctgactatgt tcatcagtta ttcctttaaa atacgaaagt ctacgatatt 2328841 tccatatcga tccgcttcaa tgtgacagca cccctcaagc agctgtttta attttccacg 2328901 tccgcgttgt acccttgatt ttgctccgga gtaagaaatg ccgagctttt cactcaactc 2328961 tttttgtgat aacccctgga aatcagttaa ctcgagcgcc tctcgatact tttcaggcaa 2329021 ccgtttgatg gtcgatcgaa tacacacagt tgcttccttg gtgaaatttt cttcctctgc 2329081 actgtcatta aaatgtagaa catcaggcaa tatttcgctt gttttttttg tacggtaaaa 2329141 atcaataatc gtatttctag tgatccgata aatccagctg tcgatctttt gttcatcgat 2329201 cagatttggg agatgcactt gtattttcat aaatacgatt tgcaagaggt catcaacgat 2329261 agattgatcg ttaaccctat gtgaaatata tgtttttaac ggctgatgaa attgatccca 2329321 tagatcctct atattcattt gaaaaaacct cctataattt tgcgtctgct ttacatttgc 2329381 ttcgtctttt taatcgtaac aaagagcaaa caattgttga atcaattgta ttgcagctgt 2329441 tgccaaaaat aatgataaag gagaggtttg ttgtggagta tacctattta gggagaacag 2329501 gattgcgggt gagccgttta tgtttaggca cgatgaattt tggagttgat acagacgaaa 2329561 agactgcgtt ccgtatcatg gatgaagcac ttgataacgg cattcaattt tttgatactg 2329621 ccaatattta cggctggggc aaaaacgcag gattgacaga gagcatcatt ggaaaatggt 2329681 ttgcacaagg aggacagcgc cgcgagaaag ttgttctggc gacaaaagta tatgaaccga 2329741 tttctgatcc gaatgacgga ccaaatgata tgaggggctt gtctctatac aaaatcagac 2329801 gtcatctgga aggatcactg aagcggcttc agacagatca tatcgaattg taccaaatgc 2329861 atcatatcga taggcggaca ccgtgggatg agatatggga agcttttgag actcaggttc 2329921 gctccggcaa agtagactat attggatcca gtaattttgc aggctggcat ttagttaaag 2329981 cgcaagctga agctgaaaaa cggcgattca tgggactcgt cactgaacag cataagtata 2330041 gtttattaga acgaacagct gaaatggaag tgctgccggc tgcacgggat cttggtttag 2330101 gagtagtggc gtggagtccc cttgcaggag ggcttcttgg cgggaaggca ttgaaaagca 2330161 atgccggaac tcgtacagca aaaagagcag atttaattga aaaacatcgt ttgcaactcg 2330221 agaaattttc agatttatgc aaagaactag gagaaaaaga agcaaatgtg gctttggcat 2330281 gggtgctggc aaatccagtt ttaactgcgc cgatcatcgg accacgaacg gttgagcagc 2330341 tgcgtgatac gataaaagcc gttgaaatca gtctggataa ggagattctc cgcatgttaa 2330401 atgatatctt tcccggacct ggaggagaga cacctgaggc atacgcctgg tgatacattc 2330461 attactcaat actgacattt ttcttaaata tttatactga actatcatat taagaaagac 2330521 aagagcatgt ttgtctcttg tcttttccac atcgtgctga aaatgctggc taaacatcga 2330581 caaaaatgct gccgcttaaa aaagaaccct aaacaataga gtaactggaa agacaactgg 2330641 cttgatcagc ttgggacccc tttcagctgt atttaaatca atcaaactaa tgattcattg 2330701 gcagtctaaa tattattatt gtttctttac aaaatagtaa tagcccctgt aatgattgct 2330761 aacaacgtaa taactaatga tgtaattaca gcccacttaa cggcaaacct ttgaaatgac 2330821 cccaagtcca ttttaagcat gcttactagc aatactgttg acgcaaccaa tggactcatc 2330881 agatgaaccg gctgccccat tatagaagcc cttgcaattt ctactggttc tataccatat 2330941 gctgaggcag cttctgcaaa gataggtacc ataccaaagt aatatgcatc atttgataaa 2331001 acaaaagtaa acggaatact agtgagtgct acaataacgg ggaaaaaccc tcccattgat 2331061 gaggggatga tggatattaa tgatcctgct atggcatcca ccatctttgt cccggataat 2331121 ataccagcaa atactcctgc tgaaaatacc aataatacca cggttatggc attaccagaa 2331181 tgctcggcga ttcgctcctt ctgcattttt acattcggat aatttatagt aagggcaaga 2331241 acaaaaccaa ttaaaaataa aactgacgga tgcttagttc caagcacaat aaacaccatg 2331301 atacttataa cgaggaataa attaagatat attaagcgtg gccttttcaa ttgttcgctc 2331361 tccaaagtag cagccatata agattgagag ctgtcctttg ttatatgtct aggctctaat 2331421 tgaacgatgc ctattcgatt cctctctttc cttcccatta gaaaagccag aaatatcaca 2331481 caagcaatac ctccaagcat ggtcggaagt aatggcacaa agaaatctga aggatccaaa 2331541 cccagcactg aaatcgctct tgtagctggt ccgccccatg gagtcattcc gctaacgata 2331601 ctcaacgaca gcattgctaa tgtcgccata accatgggat tcataccaat tcttttatac 2331661 aaaggtaaca ttgctgagac tgttatcata taggttgttg taccgtcccc atctaaagcg 2331721 ataagcattg ccaagacggc agaccctatc gctattttca cagggtctcc ctttactata 2331781 gataaaattt tttctattag cggatcaaat aaacctgcat caattaaaat tccgaaaaaa 2331841 agaatagcaa acaatagcaa tgccgctgaa cttgcaactg tttgaattcc ttctaaaatc 2331901 atgtcgccaa tacccttacc aaaacctcca ataagagcaa aaacaatggg agtgatggtc 2331961 aaggcaacaa taggcgagac tttctttgtc attattaata ttgtaaaaac agttaccatc 2332021 gaaaaaccta aaatagtaag catattacac ctccaagaat gcgctttcaa atgacttttg 2332081 attaacatat cttatacggt gtaataagtt aaataaatat ttttttactg tgtttcaaaa 2332141 aaaattctat cataacttta aatggttacc atttgttcac cctttaaaaa atcaatgaat 2332201 gctttaacga gtttgattcc taatgatttt tgatcgtaca ttagccaagt atctctcatt 2332261 agaggcttac ccttagcatt atacagttcc attgtgtaca aatgatcaga ttcctgcagg 2332321 caaatttctg gtgctatgga gtaaccaaga ccatgcttta ccatctcttt gcaagtctct 2332381 tgtcgatcca cttccattgc aataatgggg gcttgtttta gattcgtatg catccaatct 2332441 tctataatcg tttttaaaga agcatccgtt ttatatttga taaaaggtaa aaaaggaagt 2332501 tgctctatcg ttattggttt ttttgagatg atatgtaatt tttcccgtgt cagccgttcc 2332561 tccacccctt tccagcgatg gcttcctctc agtataccga cttgtacaat accagcatct 2332621 aataatttca tgacatctgt gctccagcct gtttgtacac tatattggac attaggatac 2332681 atagtggaaa attcccttaa taacttaggg agcttatatt gagcgaaatt gcttgatacc 2332741 cccagcctta gatgtccttg cacctctttg cttagattag agatatgatc tttggtatct 2332801 tgaagttcct gtagcattct tcttgcataa gcaaccaagt gttctccttc cgcagtaaag 2332861 gtaattcctt tatgcctttt ggtgaataat tcaattccga aaatctcctc aatctttttc 2332921 aaccgataag tgatggaagg ctgtgatgta aataatcgtt ctgctgtttt tgttacactt 2332981 tgttcttcgt gaagaatttt caataaaatc caatctttct catccatttt catcttcctt 2333041 tctagtcctt ctttcacaat tataaaagtt tttttatcga atattaagaa aacttatatt 2333101 ttatttttat ttttttacct tctacactaa aaaacataaa aaatactacc tttaagatga 2333161 ggatgatgac gatggtcaag acgaatgtaa caatcatgag aggcggaaca agcaaaggcg 2333221 tttttttcca cgaatcagcc atgcctaaca ataaaaacga atgggagccc tttttgcttg 2333281 atgtcatggg aagtcctgat aaaagacaaa tagatggttt gggtggcggt aattccctta 2333341 ctagtaaagt ggcaataata aagaaagcat atacttcgga tattgatgtt cactatactt 2333401 tcggtcaagt cagcatttcg gaagaaaagg tggactttaa ggggaactgc ggaaatatct 2333461 ccgctgctgt tggtccattt gctattgaag aaggacttgt aaaagcgaaa gaaccaatga 2333521 ctgcggtaag gatcctgaat accaatacga ataaaatgat cattgcggaa gtagaagtgg 2333581 aagacggtca ggtcaaatat gacggagatg ttacgatatc tggagtacct ggatctggat 2333641 ctccaatcta tttaaacttt catgatgccg ctggttcagt taccggtcat ttattgccta 2333701 ctggaaatag ttcggagttt ttagatacaa gtcaaggcca aatagaggtg tctattatcg 2333761 actatgcaaa tccattagtt tttgtggaag cgagcagtat cggcctggat ggaacggaac 2333821 ttgcagaaga atttactgat ctacagttgg ctcaatttga agaattaaga tccattgcgg 2333881 cagagaaatg cggctttgcc agtcgatttt cagctacaaa gttatcgccg gctgtcccca 2333941 aactggctat agtagcaaaa ccagagaaat ataaagatag tacaggtgct tggcattcaa 2334001 gcgttgagat ggacttacac atcaggatga tgtccatgca aaagccacat caagcactgg 2334061 ctgtcactgg agcgatatgt acaacaagag ccctttcagt ggaaggtgca atccctgcaa 2334121 gaatagcaaa aaaccactct acaaaggttc ggctagctca ttcttctggt attattgaaa 2334181 caatggtgga gcccactggt ataaagatcg tccgtaccgc acgacgtatt atggacggaa 2334241 cagtttatac gcatggagac tatcaaatga tgtagatgga ctgtgcaaaa agcctccccc 2334301 ctttccatcg ttaatagatg gattgaatgc gccttcttgc acagatccat tgtaatcttg 2334361 catggcttta aaaaagcctc tatattgttt tttatgaaat cgccaaggtc ctttcatgta 2334421 tctgcctcaa gcatgacata atcattatag agaaaattga atacttttta ctgcaaataa 2334481 aaagatacca acatcattgg tatcttttag attgagttca tctgcagcgg tttcttttcc 2334541 tcactgctta tttgattaca aaattaccgt actcgtttga acgaacatga atcggtccgt 2334601 ttagattata gttgttctcc ttggcgatag agcgaagcac gtccacacgg gcaactgatt 2334661 ctctccattc gtcacgggtg tcatgattgg ccggattcat cagatcgtca tagcgtacgt 2334721 ccaagaattt attcaaccac ttcttctcgt ctattccgtc tttaggtgat ccgcccgctt 2334781 ttttgttcgt acgtttaatc aaggcataaa aagagtcagg gtcatcacca tcgccatgct 2334841 gaataaccgt atcgtacatc acagctcttg ccaatgctgt ttttagtccg gcattatccg 2334901 atcgtttcat ggcaggctga taatacaaat ggtcatttac tttgtcttga gcggcgcgaa 2334961 attccttatc atttgcaagc gacttccagg cagaagcgaa tcccttgaga ttgcttgtat 2335021 catcgctttc ttccttggcc agacggcgca attcaggcag atactttttc agtttgttat 2335081 tcggaactgc ctttgtgtat acttccacta cttccaatgc atccccggta gccgttgtaa 2335141 agcctgcccg tccgcatgta tagcctcgcc cgtcatccaa tcgctctaca tatccatatt 2335201 ggatctccgt tgtgccgttt tcaaagatac ttgtcagctg ttccgcccgg cgcttttgat 2335261 ctttattcag tcccgccgca aaaaccgttt cgctcatcat cagggtaaaa aacatggtga 2335321 aaacaagtaa tgagatcgct gcttttttcc aaaaatctgc tttttgcata ctgattttca 2335381 tttcacttcc cctttctaaa tattgtaaat acagactcag tatacatgaa gaaactgccc 2335441 tattgttgaa aatacatcaa tttgtcaata ttttgaatct aaagtaatat agcttgaatc 2335501 ttactctatt cattgccaat cagccttagc ccctctcact gggaaggtcc cttgattttc 2335561 atactgcttc aactttcatt aacaagatgc cataaggctt tactctattt tataatggaa 2335621 gtgatcatcg aaaatcgtta gggaggtgat gtaatggcaa gcaagatgag aatgccagat 2335681 tccgcaacgt cccatgcaaa gcctactatt gggaaggcga tactttgcat ggggtagact 2335741 ttctaaaaga tcgcccaagt aagcttttct gatatagtgg ctttgcacct tatttgacat 2335801 aaaaaaataa ggagctggca gaaatggcat atgtaaaagc aaccgctatt ttacctgaaa 2335861 agctgatatc ggaaattcaa aagtatgttc aaggaaaaac aatatatatc cctaaacctg 2335921 aatcctctca tcaaaaatgg ggtgcgtgtt caggaacaag aaagctgatc gatgacagaa 2335981 acgcttctat taaaaaagca tttaaaaacg gcaaaaccat tcatcaatta tctgatgaat 2336041 atcacctctc tattgaaaca ataaaaaaaa ttgtctactc taaataaaca aaacggaagc 2336101 actgataaaa aataatcagt gctttttata tggcgagttt gtttcttagt tatttcctgc 2336161 atatgatacc attggccaat tgtgtaaagt taagggagat gagaagaaag gaaggtccta 2336221 caaatgacga taaacaatgg aacgttgcaa gtacccggcg cgaacatcca ctatcaggtg 2336281 cgtggctctg gtccaatcat tcttttggtc cacggaggag gcggtgatgc cgacaagttc 2336341 catcatgttg ccaatcatct ggctaactgg tacacggttg ttacttatga tcgccgcggc 2336401 cattcccgca gcaatctcgc caatcagatt gagggttacc gtgtggaaac acacagtgac 2336461 gatgctcacc gtcttctagc caaaatcacc aataagccgg cctatgtatt tggaagcagc 2336521 tccggggctg ttatcgggct tgatctgtgc atacgccatc ccgaacaagt acatgtcatg 2336581 atcccacacg aaccaatctt attgcagctt ctgcatggaa atgagctgaa acaagccgag 2336641 caattcatgg aagaccttaa gaaaaatcat cgaagtgaag tcattaaatt aatgtcaaga 2336701 ttagagacag acgaacaatc aaaggctgtc ctgacaaagc ggcttctcgg caattcaacg 2336761 tatttcactg agtatgaaat tcaaggaatt ctcagctata cattagattt cgaagcatta 2336821 aaaactgtgt ttacatcttc accgatgaag atactcccag ctggcggaag tgcttctcgg 2336881 gagctttttc cttatcgttg cgcgaacgcc ctagcggaac aattggaaac agaatgggtt 2336941 gaattccccg gaaatcatac ggggtacaca atgtaccata aagaattttc tgagaggtta 2337001 cacgacatgt tagaaaaaga aaagaaacat acgtgttaag gattgattaa aattttcaaa 2337061 ataggacagg tgaaactaac tatggaattg gagaagattt cacgaagcgt aaaaagaact 2337121 tttcactaac gagaacgcaa tgtgagatgt ttaaccaaag tgatattagg gatttcatcg 2337181 aaaaataggt ttgtacatta cgttctccta ttgattattt cctatcttaa ttccgtattt 2337241 tataccatta gatacaactc taaagcggct cgttattttg tcctcaacaa caaccagtgt 2337301 ctaacatcat gaatctcttt tgaaaatcac cacaaatgca ggtatggaag acttcatcgc 2337361 agcaaaaacc ataccaacta ttgttgttgg tatggttcgt cctagatagg cccttaagaa 2337421 gagattctat tgtacggagt atttagctaa ttgcatttgt aaccgacagg gccgtctgaa 2337481 cctgtgtaca catatgtgtc agacacatat ccaatattca cgacaccccg ggaatctttc 2337541 cactggattt ggtcccagat attactcgtt ccatacttcc ctgtaacagt cgttccataa 2337601 gcgtaacaat aataaggaac acgggagcca ctcggaatgg aaagcataat aggataattt 2337661 gtaccaggac cgctgcgcat attgacaggc gcaccgctgc ttgttgagac agtaaagtac 2337721 tgaacggcaa gtgcctgact ggaaaaaatg aataaagatg caatcatcac ggttaacata 2337781 ctcagcattt tcagtttagt caatgtcatc cctctttctt caattccttc attttaagaa 2337841 acgatagaac ataggctacc agctgcattt aggaacaacc ggaccgtctg agcctgtata 2337901 catatatgta tcagagacaa atccaggaac gatctccccg ctggcaagcg tccgctctgt 2337961 gtaattccaa atattgctcg ttccatactt tccagttaca gttgtaccgg ttttgtagca 2338021 atagatcggg atgcgggttc cgctcggaat ggtcgttaca attccccaac ttgtacctgg 2338081 gccgctgcgc atgttgacag gagcaccgct gcttgttgaa accgtataat actgagccgc 2338141 aagtgcatgg ctagaaaaaa tgaacacaga tgcaatcatc accgttagca tacttagcct 2338201 ctttaactta ttcaccttat accctcccct tataaatgcc gtacgtttga ctttcttaca 2338261 tccagttaag gatttacttt cagataccat gccccctccc ctcccatata tttatcaatg 2338321 taccataaac tagatctttc aaaagtggaa ttattcctat gttttcgaca attaaggata 2338381 caaaataaat ggtagtcagg cttgatattg atggtgtgtt acatttggct cttaatcatt 2338441 tgtccagtcg gtaatcacga ttgacaatca ggaaaaagga catggatcaa gcggcttcgt 2338501 ttccaccaat taactcaatc agtgtactgc ttccttgtat ccacgcttct tctcgattca 2338561 tagatactcc acctttttca ccaatcaaaa acggacacca tacaaatcag cgtaaatgct 2338621 gcaagttcag tgtccgcaac ctattatgac tttgctttct tttaccaggg cgtgtaaaaa 2338681 tgattaggta cgttatcaaa cgttattcta tgattttgcg agtcaaaaaa tcataacatt 2338741 ttatatattt caatcagatt atgatctgga tctctgaagt gagcaactcg ggcactccat 2338801 tccttgcgat catgcggttt attctcacat ttaactcctt tttcgtgtaa atcgtcatac 2338861 gttttatcaa catcttctac cttaaactga agcaaaaatt ttgattgagc ttctccttcc 2338921 aaggactttt tttcctctcc aacgatttca gccatcgttt ctcgagataa aagctctatt 2338981 ttcgtttccc cattatcaaa gagtgcatat tccatttcat tctctaacca acttattgga 2339041 agtcctaatg aatctttata aaactcgacg cttttcttaa aatcattcac caacagtcta 2339101 atttgtaaca gcttcatatc gagtgcctcc tataaaacca tacttttact ggtcatccaa 2339161 tttaatgata ccaaagaaac ctgacagcac tatgtcaagt ttccatactt cacccttatt 2339221 tcagatttaa gtgcagttta gtccatgtca taagaacgag caaaaacagc gattcttaaa 2339281 acaaaaaatg ataccgagtg tattttctgt atgcttcaac ttcatttcgg gaaatgtaac 2339341 gttgataaaa ggaggttaca tcaatatgga tcatcaaaca ttggcagctc atgaggctgt 2339401 tgacttacat gaaatcgtga actttaaaac actttgtata gcgaaatcaa agttaatgca 2339461 agggcttgtg tttgaccaag aactgaagga cttgatggaa aaagatgtac agcaatccat 2339521 tcaagacctt actgaattac aagcggttta tgagcgtgcc tcatttcagg cccctgtccc 2339581 tcaaagccgc ccaacgccaa tcatcaattg aaagggaggt aagcctcttt gaataatgat 2339641 catttagacc ccattaattc gctgaatgtg cctgaactag cagacactac attcgcgatg 2339701 gattttctta tacgagctaa ggaaggcgta aggaatactg ctgtagcttt gacagaaacc 2339761 gcttcaccag atgtaagagc actgcttcgg aaacagctga tgcaaggaat tgcgatgcac 2339821 caagagatta cggaactgat gatcagcaaa aagtggttcc atccatatga gctgagcgaa 2339881 cagtataagc tggatcagct ctctgcaaaa aacacgatca tggtcggcaa tatgaacctc 2339941 tttcctgatg aaacaaatcg caaagggatg tttgaccgga cacctgatga acactaacac 2340001 tggaggtttt acagcatgaa ggcagtaacg tatcaaggca ttaaaaatgt tgttgtcaaa 2340061 gatgtccccg atccaaagat tgaaaaatcc gatgacatga ttatcaaagt caccagtaca 2340121 gccatttgcg gatcagattt acatttaatc catggattca ttccgaatat gcaagaagac 2340181 tatgtcatcg gccatgaacc gatgggaatc gtcgaagaag ttggttctgg ggtgactaaa 2340241 ctaaaaaagg gagatcgggt aattattccc tttaatatag catgcgggga atgctttttt 2340301 tgtaaaaacc agctggaaag ccaatgtgat cagtctaatg acaatgggga aatgggtgct 2340361 tatttcggct attcagggca aactggcggt tatccaggcg ggcaagctga atatttaaga 2340421 gtgccgtttg cgaattttac ccattttaaa atccctgaat cttgtgagga acccgatgag 2340481 aaattaagcg tgattgccga tgccatgacc accggctttt ggagtgtgga taatgccggc 2340541 gtaaaaaaag gcgatacagt tatcgttctc ggctgcggac cagtcggcct gtttgctcaa 2340601 aagttttgtt ggctaaaagg cgcaaaacgc gtcatagcag ttgactatgt aaactatcgc 2340661 ttacagcatg cgaaacgtac aaacaaagta gaaatcgtta attttgaaga ccatgagaat 2340721 acagggaatt atttaaagga aatcacgaaa ggcggagcgg atgtagtcat tgacgctgtt 2340781 gggatggatg gtaaaatgag cgatctcgag ttccttgcca gcggcttaaa gcttcatggc 2340841 ggaacgatga gtgcattggt cattgcttcc caagctgttc gcaaaggagg aaccatacaa 2340901 attacaggtg tgtatggagg cagatataac ggttttccgt taggagatat tatgcagcga 2340961 aacgtcaata tacgctctgg acaggctcca gtgatccact atatgccgta catgtttgaa 2341021 ctagtatcga caggcaaaat tgatccggga gatgttgtca gccatgtcct gccgcttagt 2341081 gaagccaagc atggctatga catttttgat tcaaaaatgg atgattgtat caaagttgtg 2341141 ttaaagcctt aaaaaacgga ggttacagaa atggaatacg ccttacacga agtgcttgag 2341201 gttcaggaaa tgactgcatt taagacactt tgtttgacga aatctaaaac aatgaaagca 2341261 ctggtatctg atccgaagct gaaagaaatc atgcagcaag atgttgatat caccacacgc 2341321 cagttgcagg aatttgcctc tattttatct aatgcaaagc aagaatgagg agatgaataa 2341381 atcatgaatc ctatcataga atatctgact ggcatgaatg ttctaacaga ccaaatcatt 2341441 gctatggact tattaatttc agcaaagaac ggagtcagaa attatgcgat ggcagccact 2341501 gaagccggaa cgcctgaagt aaaagaggtc cttatccgcc atttggaaga agcactcgat 2341561 atgcacgaac aactctcaag ctatatgatg gaaaaaggct ggtaccatcc ttggaaccct 2341621 gacgaacaag tcaagctgaa tttaaaaaat attgatacag ccattcaatt gccaaccctt 2341681 taacatacaa tgactgattt gctgaggaac agtattgatt ggccacaact gttcctcagc 2341741 ttcaaaatga gcactgtttg ttcgggtcct atgaccgtaa atagattaac cgcttttctc 2341801 catctgatct ccgataatgt ttgcaaattc tccaatccaa ataaggaatc gtaaccacct 2341861 ctttttatgc gatctcttga tggagaaaac aggccagaaa caaaatcctt cgtttttgac 2341921 ctgccctctt cacacgcaaa gaatgctacc ttctttgctc cactgatccg tgaagacttt 2341981 ccgttttagg cctgcttttg agctttgcct cattttcacg caatttccca tcataatctt 2342041 taatttttgt gtctaatctc ttaattgttt catcaatttc tttccgcttc tctatcagcc 2342101 gctgtcgttc gtcagccagg atattttttc gagcttctac cgtacggtca ccttcggtaa 2342161 ataatgttgt atattcaatt agcgcttcta tcgatagtcc cgcatttcgc atgcatttaa 2342221 tgaattcaat ccatttgata tcttcttcat catagtcgcg aatgccgctg tcttttcgtt 2342281 ttacaggcgg gattaatcct acacgttcgt aatatcggag tgttgcggct gtcaggccaa 2342341 actgctttgc cacctgagca atattcatga tcttcacctc tctatcctgt atgttgtgaa 2342401 ggtaacactt aaagttaact ttaagtcaag ctcaaaacaa gtggttagct gctgaatctg 2342461 ggtttatata ttcgggactt gccttaaagc acactttaaa ctctatactt ctccatgcac 2342521 taaaaacagt gtagttggag ggattgctga atggcaaata aacacactgc cggaagagaa 2342581 caattaggag aatttgcgcc aaagtttgct gaacttcatg atgatgttct attcggtgac 2342641 atttgggcaa gagaagaaga actttcatcc cgggatcgca gcatgattac agtttctgca 2342701 ttaattactg actgtttctc agcttataaa tcaggttcat tttaaatggt ttttttaaaa 2342761 aacccttgcc ttaaagcaga ctttaaggtt tatcgttatg ttgaagacac cataaaacat 2342821 aaataagtgc atgtttttat ttacaacact tatgatgaag aaaggatagg ttcgtatgtg 2342881 taatcaacat caaacccgtg tattaagcgt gtcacatgca aaagccaaat ttgaacaaac 2342941 gacgattgag cgaagaggat tacggccgca cgatgtctta atcgatatta aattcagcgg 2343001 catttgccat tcagacattc atagcgcttt tgatgaatgg ggcggtggca tcttcccaat 2343061 ggtgcctgga catgaaatag ccggtgttgt aacagccgtt ggaacaaaag tcaccaagtt 2343121 ggctgtcggg gaccgcgttg gtgtcggctg ttttgttgac tcttgcggag aatgcgaata 2343181 ctgtctcaac gcagaggaac aattctgcac gaagggtgtt gttcaaacgt ataactcagt 2343241 agactacgac ggaaacccca cttatggcgg gtacagccaa aaaatcgttg tcactgacag 2343301 atttgttgtt cgcataccag atcgtttgga aatggatgtt gccagtccgc tgttgtgtgc 2343361 aggtatcaca acgtattccc cgctgaaaca ctggaatgtt ggccctggta aaaaggttgc 2343421 gattgtaggc gtaggtggcc ttggacattt ggcaattcaa tttgcacatg cgatgggtgc 2343481 agaagtaacc gtcctgagcc gttccatgaa taagaaagag gaagctctgg aactcggtgc 2343541 aaatcattac tttgcaacaa gtgacccagc cacattcact gcattggccg ggcgttttga 2343601 cgtgatctta aatacggtat cggcaaatct cgatgtagat gcctatttat caatgcttcg 2343661 tatagacggg acacttgtaa gcgttggagc tcctgccaag ccggacacat acagtgtgtt 2343721 ttccctaatc atggggcgcc gcagcattgc aggttctcta gtcggcggaa ttcaagaaac 2343781 tcaagagatg ctggatttcg cagctgagca tggcatcgaa cctaaaatcg aagtcatcgg 2343841 agctgaccaa gtggacgagg catacgaacg tatcctccga agcgatgtcc gttatcgatt 2343901 tgtgattgat atttccacat tgtaataggt tagtccttat atgggctgcc gcttttattg 2343961 aaactcacga aaaatgatct ctttaagcaa atattttgaa ggccggtcaa tcttcctgtt 2344021 attctatgaa tagagagtta ttaggagggt tttttatgag caaaaaaatt gcagttcttg 2344081 ttacagacca attcgaagac atcgaatata caagtccggt aaaagcatac gaagaagctg 2344141 gctacagtgt tgtggctatc gatttggaag ccggcaaaga agttaccggt aagcatggcg 2344201 agaaagtaaa gattgacaaa gccatctctg atgtggatgc aagtgacttt gatgcacttt 2344261 taattcctgg gggattctct ccggatttgc ttcgtgcaga tgaccgtccg ggtgaattcg 2344321 caaaagcatt tgtcgaaaac aaaaaacctg ttttcgcaat ttgccacggc ccgcaagtac 2344381 tgattgatac ggatcttcta aaaggcaaag atatcacagg ctaccgcagc atccgcaaag 2344441 atttaatcaa tgccggtgca aactacaaag atgcagaagt agtcgtcagc cacaacattg 2344501 tcacaagcag aacacctgat gatttggaag catttaaccg cgaatcttta aacttgttaa 2344561 aataacaaga aggcacagac tgttcgggtc tgtgcctttt ttaaaattaa gactccttcg 2344621 ttacattctg aaagacagca gtcgcgtccc acacattcaa gccaaattgg ccttctgaaa 2344681 atacggaatc atgtgcatca atcacaagac gatcatctaa atagatttta aagcgatcgc 2344741 cctcggcctc tgttttcaga tgatactttt tattaacgtc tatcggtgtt ttgtattcag 2344801 caatgacaga agcagcaccg ttctcaaatt taaagaattt cactaggtca tgcttcgcat 2344861 ccacattggc aaggtaaccg tttttggcat ctttgtcaga gcgaaacatt agtgctcctg 2344921 cccctcttcc gtttccatcc ttaatggtga tatcagattc ataagtgaag tctgacccgg 2344981 atgctgaaga caagataaag gaatcgccgt ccgacctccc ttgtttcccc tcaattgtgt 2345041 ctgcccacgt gccatttaca gtcgtccagc cagtcatatt ggacataaaa ggtgtcgttc 2345101 cccatacctt ttttaaaggg tgtatcgtta aagattttac ctttacaccg ccatttgcag 2345161 catataattc aagccctttg cttgatcggt ctgggagaat aatatccgtt atgacctgct 2345221 ttccgtcatt cccaaatact tcaaccgagg agcggtcaac aaaaatgcgc aacttaacct 2345281 tcccatttac cggcttcaac ggggctgttt cttttccggt gttaaaggcc ggattaaagg 2345341 tgtcgttgcc tgactcgctc cggtcaacga acaatttggc gttccttcgg tcatagccga 2345401 ccttcgtaaa ttgattttca cctgttcgga ccttaaaacc aaattcagca gctgaaccag 2345461 ggcttacttt aaattctgca tttatttcat aggcatctcc agattgcccc gctaacacat 2345521 tatgacttgc aggcgatatg gtcagattct tccacttctt agaggttccg cgaatggttt 2345581 ccagctcttt caccggtgtt tggaccactc taaccccttc ggtaaacgct ttcaatttta 2345641 actctcttgg aatggacgtt gcacttctcc atggggatgt cggaacatca ttcgcatatt 2345701 gccaattgct catccaccct aaccatagcc ggcggctgtc tgtggatgga atatcagacc 2345761 aggatacagc cgcataaaag tctctgccgt aatccgtcca gagaactttg tttggcgggt 2345821 tttcattttt aaaatgagtt ccatcaaagt cccctacaaa atattgcatg cctgatcctc 2345881 ccgagaccgc tccgtttccg acactgacct gcatgaccca tttcttttga ttcggattgc 2345941 cgtctaccgg aagctcaaat aaatccgggc attcccatac tcccccgtgg cttccttgat 2346001 cctgtccaaa ttcacttgca tacgtccact gcttcagatt ttttgatgta taaatgagga 2346061 ttcggtcacc ggccgcaagc accatcaccc actttttttc tttctcatac caaaagactt 2346121 ttggatcgcg aaaatctttt ttacccgggt ttggaatgac agggttgcca gcgtacttcg 2346181 tccatgttct tcctttgtcg ttgctatagg caatactttg cacttgatgg ccttcccgat 2346241 cctgtgtata aatggccaca agcggcttct ctttgcctgt ttgaaaaccg cttgtgttat 2346301 ttttatctac aactgcgctt ccagaaaaga tcgtgccttt ttcatccgga tacagcgcaa 2346361 caggaaggtg ttcccatgta accaaatctt tgctgacggc atgcccccaa tgcatgggcc 2346421 cccactgaag cccgtatgga tggtattgat agaacaagtg atattcccca gcataatata 2346481 ccattccgtt tgggtcattc atccagtttg cctccggtgt gaagtgatat tgaggacggt 2346541 aatcctcatc atagtagctt gaatcggctg catctgccga aaatgccata gtcaacagca 2346601 gggtgaacat gatcatgact tgaatcagtc tctttttcat ttgttccttc gctcctctct 2346661 tcatgtttga acactttcaa aagagactgc tgcgcaagct ggtccgtttc tggcaattct 2346721 cctctgtttc actgttatcc gaatgattta tatatgaaaa gactgctgca gtttctctct 2346781 ctttccttca cacaccttat gctaagaatc cagcccaata cccgagaatc ccgatgacaa 2346841 agatgccgca aataatgaga agtggattca cccctttgcg aagcatccat gccaccaata 2346901 acgttaatcc gagaggcagc gcccccggca taatgctatc tagcacgttt tgtaccgttt 2346961 gaacatctac ttttccgctt tcatccttaa tcctggatac aacgattgga atgttgatgg 2347021 tggtccattt ggacacgaga gcccccataa caaataaccc gagaatcgaa gcgccctctg 2347081 taagcttttg aatgcgattc cccgctaaat cctgaagaat ctccattcct ttcacatagc 2347141 catactttaa tccgtaatat tttgtgctta atcttatggc attcagcaag aaaaagaata 2347201 gcaaaggacc ggcaatgttt cctcctaaag caagggaggc tcctagcgca gctaagacag 2347261 gacgaatcgt tccccaaaaa attggatcgc ctacgcccgc tattggtccc atcaaaccga 2347321 ttttcattcc gcttatcgct tttccgtcaa ttcctttatt gttcgccatt tcttcttcca 2347381 tggctgccgt cacgccaaat ataggcgctg tcagccacgg atgtgtatta aaccattcca 2347441 aatgccgctg taaggcttcg tttcttttcg ctccgggacc gtacaatttt ttgatcgccg 2347501 gtatcatgac ataacaatat cccattgcct gcacacgttc gaagttaaag gaaccgagta 2347561 aaaaatttga acgaataaac atgctgaaaa tttctttctt cgttaatcgt ttttctttct 2347621 ccattttttc ttccccctca tcgtttaggc atcaagatca tcatcatcgt catcataaac 2347681 agcaacactg ccactgtctg atgcggccgc gactgctccg tgagcgcttt gtttttgcat 2347741 cacctgctgg tataaaagcg ccagacagag accaagggct ccaaatccca ctaagttaaa 2347801 atcggtaaac gccgctaata agaaaccaat atagaaaaat ggctttaaat aaggaatatt 2347861 catcatattg atcaccatgg catacccgac aaccacaata atgcctccgc ctatttgcag 2347921 tccttttgta atgacatcag gaatatttcc caggaacgcc tgaacagcgc tgacactaat 2347981 taaagcaaca atcaatgtag gaatcatgac gcgcaaagct tgaaacacca tcgcggtaat 2348041 atgcataatt tcaattcctt ttatatttcc cgcttttgca tattgatcag cgcggtggat 2348101 gaaaaagaca gtgatcgtcc gaacaaaaat cgtcagcgcc tgacccgcag ctgctaaagc 2348161 aacagcgaca gcaatccctt cgccaattcc ttgatcagcg gtaataacta aaatggttga 2348221 gatgacagag gcgatcgctg tatcaggtgc catggcaagc ccgacgttca tccagccgag 2348281 cgccatcagc tccagtgtgc ctccaagaat aattcccgtt tttaagtccc cgagcaccaa 2348341 gccaaccaac gtacaggcca ctagcggccg gtgtgtctgc ccttcatcca atacacttgc 2348401 gattccggtg attgctgcaa tgattaacaa caaaataatt tgtaatgaag acatattctc 2348461 atccccttga ttattttgtt acgttccgta aaatctgtac aaaatcctca ctggcatctg 2348521 aaggcagctg cctcaattcc agtttcacgc ccttgtcact taatgtttca aatgccttta 2348581 tatcttgttc tgtgacactg actgattttg tgatttgcct gcgatgattt tcaaaacgca 2348641 ttcccccgac gtttacggtt ttgatcggta cacctgcttc tataagagat acaatatcgg 2348701 acggattttc aaacaagagc attgccgtta ccccttcgta gcgcggacta tgaaatgctt 2348761 ttgccatttt agaaaccgag acggcactcg cctttacatt tgaaggcgca acagaaagga 2348821 tcagcgtttt tctcatttcg tcctgagcaa tatcgtcgga gacaacgatg attcggtcgg 2348881 ctgcatggac ttttatccac cttgtcagga tttggccgtg aataaagcgg tcatcaattc 2348941 ttgctaacac aatgttcatc ataattcatc ctctcttgta tcttgattgg ctgtttttac 2349001 tttttctaaa tgttcactgc acacttgaaa gctttgctga ctcattgctt ttaagttgtt 2349061 cagcaaatct ttgagagcca gatgttctct caggcttaat acctccagca gaatcggcag 2349121 gtttacgccg gcagccatat ccattctttg atcctcagca ataaaggaag ctgccgcgtt 2349181 atatggcgtc cctccaaaaa tatcgactaa aaaaagcact tcatgttctt ccgggatatc 2349241 cttgagcgcc tgatgatatt tttcttgcag cgtttgtatt ccttcccctt tgaaaaacgg 2349301 cactgcaatc aggttatttt cttcaccgaa tatcatccct gaagactctt ttaatgctat 2349361 gggaaaatct ccatgaccgc tgataataac tgaaatcata tctattgctc ctttcctgtt 2349421 ttgtacatcc atatataatg caaggatcgt gccaacacag ttgtgttaag cgttttcatt 2349481 gttatttcag ccaatagcaa tttgttgttg aaacacttaa aacgaaaaaa ataaacctgt 2349541 attaaaatgg tgttccattt aatacaggtt catatgaaaa aactgttttt aaaacagctg 2349601 gccatgcact tcttcagcaa atatggcggc tataaataat ttttcatcat cacttatgcg 2349661 aagtccgagc ttttcttcat aaggggctaa tgttcgctct gtcacgtaca ccatttcctt 2349721 cagctgatca ttgatctctt cttcctctga gaaagcgatc ggattctgct taattaccct 2349781 ttcaaaggcg aaagccgtgt gcataatgac tttgatcaaa accgcattat tgaaaatgac 2349841 ccccagctca tcctgaacgg tttgcagcca ctccaataac atgtcgatca catggtgggg 2349901 attcaagaag acaaggtatt ttttcaggct atcctcgcaa agctccctga caataatatt 2349961 tgcttcgttc aatccattgc tcaaggagat gcttcctttt gtaatcgcct gttgaatcag 2350021 cttctctccc tccccttcaa ttaacacttc taaagataca tgcggagcat tgattttagg 2350081 gtctttcgtt ccgactgtcg caaggatttc atactctttt tcgatttctt ttatgctgtt 2350141 ggccagctta atcgatgata cggtcaatat gtgaatgggg gtatcggagg ccttgtttac 2350201 gatcgtggtt agaatgtctt ccagcttttt ggccgttccg ctacccgtcg tgcagatgga 2350261 taccaatgcc ttctttttgc cggatgccgc tggctgacgc tcccacaact cgataaaatc 2350321 cttcgtgacc gattgataga tcgcatgcaa atttaaattc aaatagttga cctttctgac 2350381 agcatccagc accattgaag tcgtaacatt gctgatcgtt ttaatagaaa tgcctgtctt 2350441 ttcctccagc ctgctttcca gcattgcaag cgaccccata tctaccagca ttaaaacacc 2350501 ttcaccttca tcaacctgtt tcattttttc tgctacgcat tcaagaatgt ccgaaggtga 2350561 aacagtaagc ggcatgtcaa ctgctgcaat cggcgtactc cctagcagtt ctgtcgcgac 2350621 ttcaaccatt gaactcgccg tgctgtttcc atgagctgcc acgataatac cgactctttt 2350681 gttctccttt aacgatttga tggaatgaat taacatcgtt aagtagatga cttctatttc 2350741 aggaatagcc actttaaaat attcctgaat tttatcttta aaaatcatcg ccacccgata 2350801 ttctttcaca tgggtatcac gaatttcatc tgtctcctgt gtattcaaaa catcaatttg 2350861 ctttcctcgc tttaaaaatg cgtcaatatg catactcaag aaataaataa acttacggtc 2350921 aaatgtgcaa tccagctcat gttcagctat ttcttttaac tgttttgtca tttgaatcac 2350981 atcgtcttca acgaatgtca gcaggttgtc tttttgaaaa gcttgatgat gaaaaaaact 2351041 tctgacatgc aaatggacat cagtcaagat gtactggtta atatcctttt tggataaacc 2351101 ttctttcata agcgttttca ctttttcctc aatcaaatga tataagttaa atgagaggtc 2351161 ttcgtcaatt tttgttgttt catcttctac aatcggagag ataatcgttg taatattgac 2351221 atattcagaa atggctttgc ttctttgcat gtttttgctg ctggacatcc attcttgctt 2351281 gatttcatca ggcagatcgc gaacagtcag ttcaataact tcatttctgt caaggttatg 2351341 caaaaatccg tgtgcgcaaa ctaactgaac atttgatttc agctgtccga cattcccaaa 2351401 tttcgcagag tgaataagcg cattatagac atcgatatgc acactcagat tcttcttaat 2351461 tcgctctgct tctttcccta ataaaaacgt cgtcagatcc actctttcat taagcgatcg 2351521 ttcttcaagc gaaggaatat gaatggtcat tgggattctt cgcaaaaacg ttttcaatag 2351581 tgcagaactc ggattttctg tagtcgcaca aataaacaat acgttcgatg ttcgtttatg 2351641 ttcagattct ccaagcctgt tataagaacc gctgtcaata aaataaaaca gcatttcttg 2351701 tccctcggga gggagacggt ggatttcatc cataaaaaga atgcccccat tggcctgttc 2351761 gactaaaccc gccttatcct cggcagcacc tgtaaatgaa ccttttttgt gtccgaataa 2351821 ttgagaaagc aataattgag ggttgttgta gtagtctgca cagttaaatg taataaatgg 2351881 tgcgccggcc ttcaatatgt cagagtaaat ggcaaactgg taaattcggt tcgcaaaaag 2351941 ggatttaccg gaaccagtcg gccctaggag gagcatatgc agaccgttcg gcggataaaa 2352001 gacagctgct tttgcctggg agatcgcttt cttcaaactc ccttttgccc ctatcataag 2352061 ctctagggga ttcgtggaaa tgtgttgatg attttgcttt gaatttccgg aaaacgcctg 2352121 aaggtctttc acttccatca tctctgtatc ccatttcttg ttgaataatt tttctgctat 2352181 ctcgactggg atgtatctta caggaaatgt tttaattttg atgacctttt tggaccggac 2352241 gagattgttc aattcaaagc tgacattgga ccgctccatt ttcagctgct cggcaatctc 2352301 ctttgctgaa ttcccttgta tttttaaaag atgatctaag gttgaatcat gaaaattatg 2352361 cttgagctga tggtatattt tatctattct tctcacgtct atcatccttt gtccttatta 2352421 gataagccat taacaagaat atttcgaaac tttatagtcc gcgttgagat ttacacgttt 2352481 aaaaaggtct ctatagcaga ttgacaaagc tggcttttat gcgtatatgt ttacatgttg 2352541 aatcatttgc acctcatatt agtatgatag atgctcagtt ctggagggcc agtccccttc 2352601 aaaagtaata atcagtaaac agtttatcat tctcggggaa tgtaatgatg tcaaaataat 2352661 caatgacaaa aaatgaatct tatagatcat gacaaattac ccaaatataa ccccttaagt 2352721 tcgttcacaa ctaaaaagac ggacactcta tgtgaccgcc acagtattac aatttgcaaa 2352781 acttcgtcat ttttgcaatc cacattggag gttaaggaat ctgtaagctt aaaaacttta 2352841 tctccgatcc tatcgatttg atccccctgc cggcctcaat catagtgggt atgcaattat 2352901 acaaatcgtt accgattaaa actagcctgt cagattgtcc aaatgacttt cctgttttac 2352961 tctgctattc aggtagaatc acgagtgaaa aatagagcca caagacatgt aacagcactt 2353021 aaaatagttt taaaatttaa aaataaaagt atctattctt ttaaatgtta taatatccga 2353081 taaaacttta ctcatctttt tattactgga ggaaaataaa attgataggc aattctagca 2353141 aagacaattt tggccagcaa cagaaattgt ctagaggcct taaaaacagg catatacaat 2353201 taatggcgat tggaggtgca atcggtacag gtttattttt aggttcaggt aaatccatcc 2353261 attttgcagg accatccatt ttatttgctt acttgatcac cggcgtattt tgctttttca 2353321 ttatgcgttc gctcggagaa ctgctcttat caaatgcggg ataccactct tttgttgatt 2353381 ttgtaaggga ctatttagga aacatggcag catttatcac tgggtggacc tactggttct 2353441 gttggatttc cctcgcgatg gctgatttaa cggcggtcgg catttatacg caatattggc 2353501 ttcccgatgt gcctcaatgg ctgccgggtc ttcttgcgct tattatcctg ctgatcatga 2353561 accttgccac cgttaaactt ttcggagaat tagaattttg gtttgcattg atcaaagtca 2353621 ttgccatact ggctctgatc gtaactggta ttctcctgat tgcgaaaggt ttttccgcag 2353681 cttccggccc tgccagcctc aacaaccttt ggagccacgg cggcatgttc ccaaatggat 2353741 ggcatgggtt tatcctatct ttccaaatgg tcgtcttcgc tttcgtgggt attgaacttg 2353801 ttggactgac agcaggtgaa acagaaaatc cccaaaaagt gatccctaaa gccatcaatc 2353861 aaattcctgt ccggatttta cttttttatg ttggcgcact tttcgtgatt atgtgtatct 2353921 atccttggaa tgtgttgaat ccaaacgaaa gcccatttgt tcaggtcttc tctgcagtag 2353981 gcatcgttgt ggctgccagt ttgatcaatt ttgttgtatt aacatcagcc gcatcagctg 2354041 caaatagcgc tttattcagc acaagccgaa tggtctattc acttgcaaag gatcatcacg 2354101 cacctggact attaaagaaa ttaacttctt ctaacgtgcc aagcaatgcg ctgttctttt 2354161 catccatcgc cattctgatt ggcgttagtc tgaattattt aatgcccgag caagtcttca 2354221 cgctgattac aagtgtttca acaatatgct tcatttttat ttggggcatc acggtgattt 2354281 gccatttgaa atatcgaaaa acaaggcagc atgaagcgaa agcaaacaaa tttaaaatgc 2354341 ctttttaccc attatccaac tatttaacac ttgcatttct cgcgttcatt cttgtcatat 2354401 tggcactggc gaatgataca cgtattgctt tgtttgtcac cccggtctgg tttgttttat 2354461 tgattatttt gtataaggtg caaacccgca gaggacataa ggtgaaataa aaaaaagaca 2354521 agggatactc actcccttgt ctttttatat gtgtcaaaca ctaaattaaa ctttggtttc 2354581 aaatttcatt cacttcattt aagtgttaac tcaaaccagt tttgatgccg aaacctacta 2354641 atattattcc ggtaattttt tgaaacactt tctggaactt cgagtttttc atccattttt 2354701 ttgcgtaatc aataatataa acaagaaaca ggaaccacaa caccgctaat aaggttagga 2354761 ttgaagctaa aatgatgagc tgctggttta tatttccgtt caaattgata aattggggca 2354821 tgattgtaac atacaccaaa acagttttag gattgagaat gttactgagt gatccctgca 2354881 taaaggaagt tttataataa cgtttcggag aacttgccat attttttgct tgggattgca 2354941 tgtcatctaa cgaaaacata cttttagcaa aaaaactttt tacacctaaa taaattaagt 2355001 atgccgctcc caaatatttg atcgttgtga aaagaatcac tgactttgcg attaccactg 2355061 ataatcctaa aatggcaatc accgtccaaa aggaaagtcc tgtcgccaat ccgagaatgt 2355121 tataacggcc ggctttcgga ccatacctaa gcgtattttt catcacaagc atcgtatctg 2355181 cccccggtat gataaccatc atggcagcga tcggtatgta tgcgagtaag ctgtgcattg 2355241 ttctctcccc ctttaaaaat cccctcaatc atatagtgac tacaaaagta actacttata 2355301 aaagtgtatc aatgcgtttg gaataaatca atatgatttg ttaaaatagc gattactaag 2355361 gcagcgattg ctctttatat tggaggatat atgaaagaaa atatgttaga cattttaaaa 2355421 aacctcaatt ttacagaata tgaatcgaaa gcgtatttag cattattgca agaatcacct 2355481 ttaacaggct atgccgttgc caaaaaatcc ggagtgcccc gttctaaaat ttatgaagta 2355541 ttggaaagtc ttgtcataag gggagatgtt tttgtcagtc atggaaatac gcctcagtat 2355601 gttccagtcc ccgcaaaaga actgattaaa aaccgccggc tcaaagcgga agagcatttt 2355661 gatcaggctg agaaatattt tgaaaagttc gagcagaccg caaatgaccg ggaaaacatc 2355721 tggaatatca ccggccgcag tgaaattctt gaaaaggtga aggcttgtat cttatctgcc 2355781 aaaaaaagaa tcctcttaga aatatggaaa gaggatttta aggagataga agcagagctc 2355841 aaacaggcgg cagaacaagg cgttattgtc accattattg cgtacggaga catcgtatct 2355901 gattttgcca atgtttacct tcatgatatg agcagtgaaa ttacagaaga gtatgacgga 2355961 cggtggcttg tctatagcgg agatgattca gaagtagtag cgggcattgt ctcacttggc 2356021 aacgacagcc gtgctgcatg gacgatgcat gtagggttag tcatgcctat tactgaagtg 2356081 atcattcatg atctgtacct catggaaatt ctgaaaaagc atagagagct tttagaagag 2356141 agcttcggga aaaatctcat ccagttgcgc cgtaaatttt ctattcactc agatttcaaa 2356201 aaacattatt tggaataatg tttgtcatct cttaccccaa aaacaaggct tgtacaaaac 2356261 aagccttgtt tttttatgca taaacccccc atgctgattt acttctctct tttaaaaaat 2356321 gtgattctgc gcaaactatt tttcagcctg ccgcgtctat cctaggtaac agcctacgat 2356381 atacgtatat tcaaaaagga gccctttatt gcaatgaaga aaaaacaaac aacaaaagcg 2356441 ttgcttgtca catgcataac tgaccataag caagatttct acaggttggc tttcagttat 2356501 gtgaaaaatc aagatgacgc attagatatt gttcaggaat ctataaaaaa agcgctgagc 2356561 tcagttgaaa cggtcaggaa ccctgagacg ataaaaagct ggttttataa aattttagta 2356621 cggacagcca ttgacttttt gcgcaaacaa aaaaagataa gagtgatgga cgacgaaacg 2356681 atagaatttt taagcaaagg aaaggaagac cattacaagg atactgatct ccatgaagcg 2356741 cttgacgaat tgccgtaccg ctataaaacc attattattt tacgtttttt tgaagacctc 2356801 aaattagaag aaattgcgga aattacagga gaaaacacga ataccgtcaa aacgcgccta 2356861 tacagagcat tgaagctgat gcgcattcag ttgacgaagg aggatctttc ttaatggata 2356921 agagattaca gcaattaaga gaagaatata aaaatgttca gattcctaaa gaattggata 2356981 tcattgttga aaaagccctt cagcaagaac caaaaaagaa aagaatcgtt atgtggccga 2357041 catcagcagc aatcgctgca gctattttat tcactgcgct tgttaatatc aacccggacg 2357101 ccgctcaggc tatgtcaaag atccctgtca tcggcaaaat cgtcaaagcg atcaccttta 2357161 ttgaaatcaa agaggaaaaa gaccaatcaa gcattgatgt caaaacacct gctttgtccg 2357221 ggctttctaa taaagagctt gaaaacagca ttaacgagaa atacttgaaa gaaagccagc 2357281 agctgtataa agagtttata cagtccacat ccaaaaacaa aaaagggcat ctcagcatct 2357341 acagtgatta cgagacggtc acagacacgc cagatttact ctctatccgg cgcaatattg 2357401 aaacaacaca agcatcttcc tacacacaaa gccgttatat tacaattgac aaaaagaatg 2357461 atattttact tacattaaaa agcttattca aagatgagcg ctatatcaaa gtcatcagtc 2357521 aaaacatcaa agaacaaatg aaacagcaaa tgaaggaaga tccaaataaa atatattggc 2357581 tcactgacga agatgcagaa ccgttcaaaa cgattcttcc tgatcagacg ttttacatta 2357641 ctgaagacca taaacttgtg atctcatttg acgaatatga agtcgccccc ggctatatgg 2357701 gcgttacaga gtttacaatt ccaaccggcg tcatttcaaa cttgctcgtg ggagaacgtt 2357761 atattcgata aaataaaaac atccatctaa gattatggat gttttctctc ttctctattc 2357821 gaggtcgtaa ccccgctatc aaaaacaacg agaatatttg catactattg gaggaatacc 2357881 catgtatcac aagacacagc atcatcgata cattcctgga cttgatggcc ttcgggcttt 2357941 cgccgtcctg tcagttatca cttatcacct aaatttcaat tgggctaacg gtggttttat 2358001 cggggttgat atcttttttg ttttatccgg atatttgatt acatctattc tattaccggc 2358061 atatggaaat gatatcaatc ttgattttcg ggatttttgg gtgcgccgca ttcggcggct 2358121 tctcccggca gcgtacctta tgatcttttc cactgttgtg tgggtcgtat tgtttgatcg 2358181 agaactattg cacactgtac gtggagatgc gatctcttct ctcttttata tgagcaattg 2358241 gtggtttatt tttcacaagc tatcatattt tgatagtttc ggttccccat cacctctaaa 2358301 aaacctttgg tcgctggcga ttgaagaaca attttatatc atatggccga tgtttttagt 2358361 tgttggaatg tacataatga aaagccgcgc cagattggct gcggtgatat cattgcttgt 2358421 gctttgttca gccgtgatga tgagcgtact gtatgaacct ggcggagatc cgagccgcgt 2358481 ttactatggc acagacactc gttcgtttga acttctcatc ggatgtgcct tggctttggt 2358541 atggccgatg aaaaggctgt cttccaacag gctgccaagc aaactgaagc acactttgca 2358601 cgccactgaa tttttggcat tttgtatttt agtgttgtgt gtctatttca cagatgaata 2358661 cgagcctttt ctttacagag gcggaatgct attcattagc gtgactgccg caatccttat 2358721 tgcatgtgtt tgccatccga gcagcttttt aggcaatctg ctttcatgga ggccgcttcg 2358781 gtggcttgga acgaggtctt acggaattta tctttggcac taccctgtta ttgtgttaag 2358841 cacgccagtt caagaaatcg gaaaccctgt tttttggcat atcgtgctaa aggtcattgt 2358901 gacatgtata cttgccgagc tctcctacca ttttattgag aagccgatac ggacacaggg 2358961 atttaggtca ttttcccgcc gtgtttttat acatagaatc aaggaatgga aaacgacatc 2359021 tgtcatcagc aaaatgtcaa ttggtttcat tattttcgct atacttattt ttgcaggcgg 2359081 gctgtcaggg ctagccggcg agcaaaagca ccctaccaaa tggacctata gctcacaaga 2359141 aacaaatgct gacaccagcc aggcttctgg ggataaaaag aacgctgcag cagataaaaa 2359201 acacaatcct gaacaaaaga caacagattc caatcagggt caaaaggaaa acaaagatag 2359261 tgggcaagag actcataaaa agaaagacac gcaatcccaa cagttgaaaa aaccagcaga 2359321 cactgcgaaa gaagttttag ctataggaga ttccgtcatg cttgatattt cttcacacct 2359381 gcgtcagtca ttttcaaatg tgacgattga tggaaaggta gggagacaaa tgtctcaagc 2359441 tttggaactc gcaagggaat acaagtcttt taatcagccg aacaaggctg tcatcattga 2359501 gcttggaacc aatggctatt ttacaaacag ccaaatcgaa caactgcttc aatctttctc 2359561 aaaagctcat atttatcttg tcaatacacg ggttccccgc caatgggaaa gcaaggtaaa 2359621 tgaatctttg cagcaacagg cccacgcaca tcaaaatgtt acgttagttg actggcatac 2359681 agaagctctt cagcatccgg aatattttac ccctgatggt gttcacttgg ttcctaaagg 2359741 ggcaaaaact ttgactgctc ttattgttca ggcgatgaaa tcgtaaaaaa gagatcctat 2359801 acagatcact tttttacttt agtttctgat cgttgattat gtcttctttc agcaaggcag 2359861 cccttatgtt tacatgccgt ttacgtaagg gtaagccaaa attgaatgga gggatgataa 2359921 tgaaaggaaa tgaagaacat gacatccaaa aagagttgaa acgatatgag ctttttttca 2359981 aaaaacgata taaggttctt tatacagtaa acgattttat catcggtgct atgtttctcg 2360041 ttggaagttt tttctttttt tatgaccggt taatgtcggc agggatatgg ctgtttgcga 2360101 tcggaagttt gctgctgtta atcaggccga ccattcggct gattcatgac tttcattacc 2360161 gtaagcatgt ggaacagcaa ttcaagcatc aatcttcaac agatgactga tcttaaggaa 2360221 taagaaagaa caaaatgcca aaagcctgag tcgaaaatca aaaacaagac tttcagacta 2360281 tttattttta aaaacaaggt aaaaagaact aaacttttgc ctctgcatgc cgatatgaat 2360341 aataaggccg gcgcgatact ccctataaca tccttttcag tagatttcat tatcgtgccg 2360401 gttttctcat atgcaaagca atcccgccaa tcagattggc gggattttat attttacatt 2360461 cctgtccaaa cgtctttcac ataacgtctt tgatcttgca gcttttgcag ccatacagct 2360521 gattcttcct gacttgctgc tttttcagct tcatatgcca atcgcaaagt tctctctaca 2360581 tcaggagcca tttgcgatcc atcaccgcat acgtaaatat gagccccttt ttcaatgagt 2360641 gtcatcaatt tctgcgtatc ttgcttgagc aagtgctgga catatccttt tggttcgttt 2360701 tcgacgcgcg agtagcatcg gcggattgtg accaaaccgt cctgttccgc ttgatccagc 2360761 tcttctctgt aaaggtcgtc atggtccggg cggcggcagc cgaagtataa aagtgcttca 2360821 ccaagggtgc ttccttcctt cttcaaaacc gatcttgcct gaataaagcc tctgaatggc 2360881 gcaattcctg tgcccggccc gaccataatc ataggcgttt caggatcatt cggcatctga 2360941 aatccggact gcggcgtacg aatgaagcaa gctgctgcat cacctgtatt caattctgct 2361001 aaataattag aggcgacacc ccggtattca cctcggccgc tccatgctga ggctttcaca 2361061 actcctaccg tcatgctcac gatatttgca tgaactttcg gtgagcttga aatggaatag 2361121 tatctcggtt ttagtgatgg caaaagtgct aaaaaccgtt caaacggcat ttcgcaagca 2361181 ggataatcct ctaaaaaatc aagcatggta agacgttttg caagtacctg ctctttgtaa 2361241 atgccatcat ctgaaacgag ctgttccagc tctttttgat gcggcggaca aactgtataa 2361301 gaggccagct cccgaagctg aagccttgat gccggttcct gcagctctac ataggacgac 2361361 aataaatcca ctactttgat tggccgatcc atcggcagat gagccatatg agcgcttccg 2361421 cttactttta tcacatgatt ggactgcaaa ccgaatcggc tgagaacccg ctgaacaagc 2361481 tccctgctgt tctttggcag gattccgata tgatcgcctt ctttatatgt tttaccagcc 2361541 ggaatttcca attcaatatg gcgggttgaa cgcgtgctgg cagctgtctg gagttctcga 2361601 ttctctaaca caatcccttc aaacgcgcca tatgctttag caaccggcgt ttccgtcgct 2361661 tcactgagaa aagtaatcga taatgaaggc ctgtcttctt tctgggctat ttcgttaata 2361721 tcaaatgcgt ccatcgtttc cttccagaag cggttttccc aagactcgcg gtggctttca 2361781 aaatcatcgg cggcgtcacc ttccccaatc gctgttaaac gcgatgcccc ctttgctttc 2361841 atcatgtcat caatcaggcg gggaatccgc tgatacgtgc tggcccagct ccggtttccg 2361901 cagccgaata ccgcatagga aacacctttc aattggcctt cctcaagctc tttcagccac 2361961 tctacaaatc cggcagcatt atcaggcggc gccccattat aagaagccgt tacaatgacg 2362021 actgcccctt cttcagggag cttgccgata taatcatcaa gcggagccgt ttcagctgta 2362081 aagcccatct ggcggccttg agcagccagt tcaccggcta ttccctcagc tgtcccaaga 2362141 tttgaaccaa aaagaacaag taaaggtgtg ccgtgtttag gtttggtttc ttttggcttt 2362201 gtttctgctt tgatgtctgc ctgttctttt ctctgtacat tgattgccgc tgtttttcgc 2362261 ggtttcacag taattttaaa atcatccggc ttgatcgtta atgcttcttt gatttttagt 2362321 tcgtagccag tatggtttat caattcaaaa tgctttaata caagaccgag aaccattgtc 2362381 gcttcttgaa gagcaaactg catgccaata caagcgcgct gtccgtttcc aaacggctta 2362441 tacgcatggt gagggatact tgaaggatcc tcaaaccgtt ccggacggaa atcttccgca 2362501 tccggtcccc aagcgttttg atcccggtgc agttttggaa ttaaaacagt gactggctgc 2362561 cctttgctga tcggatattc cccgcctaga acagtatcct ccttcgcata tagagaaaaa 2362621 gccggagctg ttggatacag tctgagggtt tcatttaaaa ccatccgaat gtatttgagc 2362681 tgctggattt gtttatattc aggcgtgtca tccgttaaca cgcgatccgc ttcctcctga 2362741 gcttttttca gtttttccgg atgtgtaagc agacaataaa tcgcaaagga tagcaacccg 2362801 cttgttgtct catgtccagc aattaaaaat gtgatgattt ggtatcgaat gttttcgtca 2362861 tccagcgttt cacccgttac tggatctttg gcataaagca tgagagacaa gagatcctta 2362921 atgttttcat ccggattcgc ctttcgctcc gctatcattc tatcaaccag ggagttcatg 2362981 acttctatat ccttttggaa ctgcagcttc gttttcacca tcattttatc ttgcaggccc 2363041 agtcttttcg attgattcat cgcctctttt aaggcacgga gcatactggt gataaacgga 2363101 tgctgtgaat cacggtaaaa gctgttgaat cgatagttaa acccgcataa cccaatcgta 2363161 tcaagcgtca gacgtgtcat atcgtccgct acatcaattt cttcattagg gtttaaccgg 2363221 ctccactttt gaatcagctg ggttgcgata tccagcatca tagaatgata gcctttcatc 2363281 gctttttgac taaaactcgg cagcaaaatg cggtgggctt tttgccagtt cggttcgtgc 2363341 gtccagcttg taaataagcc atctcccccg aactcacgca ccttttgcaa gcctttgcca 2363401 aggttcttgt caaagcgttt ttcatcacac acttcagcca caagattgtg gccggacaca 2363461 aaaacactgg atactcccgg aaaatcaaaa cggaaaatcg gtcccaattc atcagctatc 2363521 cgccataagg attgagaaag ctgttctttt tccagatgcg gaagattttt taaaggtccg 2363581 tatgttttgg gctgaggtat tgcgcttgcc tgtttcatta acatctccct ttcctatttt 2363641 tgtgatgaat gaagcttaat ggcgtcccag cagcattgtt ccaattcagt aattaaatca 2363701 gtgtccatct ctatatcacc tgtttgaacg agctgatata tcttgagaaa cgcccctaat 2363761 acaatcgcaa ttaacacatt agagggcagg ctgcgaatca cgccttccgc ttttccctta 2363821 ttaaaatagt catcaagcat ttgagtcaga ttttctatca tttttttgct tgtatgattt 2363881 aagtaatgag cgtctttttt ggtttcaaga aaaaaaagcg catagtcgct ctctttcgta 2363941 aactgaacga gacagcaaaa tacgtggtga aagccttctc tgacaggcaa ttctgaaacg 2364001 tcttgcttca gtttttccgt aaatcgctgg atgctttctt gaaacagtac gttaacgagt 2364061 gtttctttgc tgtcaaaata acgatagatc gttcctgtcc ctacatgagc acgttcagct 2364121 atcataggaa tagtggtagc gtcaaaaccc ctttccgtaa aaagtgagac tgacgctttc 2364181 ataatcatgt cgtatttact gctggatgcg gatatcatgt aatctgacaa cctccgattc 2364241 gtttacggaa tgaatattca ttccttttgt tcacaaagaa tgtctgccct gtctgatatc 2364301 acctctttgt tctttcttct gttataagtt tatatgaaaa aaactttttt taatataaag 2364361 tatatgcaaa aaataaaaaa ttaagaaaat atacccaaat cctaatacga ggatcttgga 2364421 tatatttccc gagaaatttt ttatttaaca gccacaatac atagacagga agcacgcctg 2364481 ataacagaaa gatccctgaa atgctggtct ttcagcagtt gaatatacgt tttctctttt 2364541 tcaccggtat ttgtgtcaat actgatataa aaccggccgt caatttgaag caccctgtaa 2364601 atttctctta atgcaagcct aatatcggtg cagctttgaa ccgtatgtaa agaaaagact 2364661 ttattaaagg tacggtcatc aaagggaatg tcctctggat agccatgaaa aacctccccg 2364721 ttccccatgt tctttcgatt cgcacgtgat atctgtctta cctttcgttt tgaaggatca 2364781 atgcttttta ggctaccctt ttttagtttc ttggttatgc ttttaaagac agtgccgttt 2364841 ccaattccaa tttctaaaat tctgtcattt tcttgtatat ctatagagtc aatcatcata 2364901 tgctcaattg ttttggttag cttatatttc cgagaaaata atttccaaaa atccgatcgt 2364961 ttatagagtc tattttctag cattttaaac acctgctttt ggtttcctat gtttatttat 2365021 tatcttaaaa aaataaacat catcttcatt tctaaaagtg aaggaaggta ccaactagac 2365081 ggcaatgtat tgaaaaatgt ttcaatagaa ctaaactttt tcattttttt ccgaaaaaaa 2365141 agcagaaaac ataatgtttt ctgccctctt tctaatgcca atgataaggg aatacataca 2365201 gcctttgctg ctgcattgcc atcagcctct gctgtcggaa tggatttcca taaccatgtt 2365261 tgaaggaatg cggcatggac gcataaccat ggccaatcga cggcagtctt ttttgataat 2365321 cgttcatcat gccatcacct gcctcacaat aacgttgatt tactatatgc aggcgcgcat 2365381 tttcttgaca gctatttcgc taaacttggt ccttctccat tgtataatgc atcaatagtt 2365441 ccattctaag catatgccat tcccccttca gtttttttcg ttgcttttag cgccagtttg 2365501 ttaaataaag atgctttaac tgagactctt tcatttcatc ataaatttgt tcaatctgct 2365561 gttctcgttc gaattcttcc aggcttttaa accgtttttt aatcgttaac gttaaaaaga 2365621 ataggttaat cgtcatatcg ctcaccccct ttcaaagtcc gcatcaagcg aaataacccg 2365681 cggcacaacc cttctgccgc gggcaaataa aaaccgcaga caaaagaaga caccaatgcc 2365741 tctactgcct gcggggagtt gcgtatgtcc gactattccg aatttaatgc gtgcgataag 2365801 catcggttaa ggaaggacac gaactcttcc acaggctgaa taaaccatga acttttacat 2365861 gtgtatcacg tacaggttga cgtcgttgtc tcattgtcat tttggttcag cctcctttgc 2365921 ttttttctta ctttgtaagt atatccacca aattccattt tgtaaacatc tttttctaaa 2365981 aatggacgga aattgtgcaa atcatcgaat ggatttgccc gttggtcatg acacctgctt 2366041 catttctttt ctggagcggt ctttcttatg atatgcaata aaataaatga gaccgacaaa 2366101 tacagctccg ccgatgacat taccgataaa agccggaatg atgtttccga tgaactgccc 2366161 ccacgtgaat gagcctgcaa aaatggcagc aggaatcaca aacatgttgg cgacaacgtg 2366221 ctgaaatccg atagccacaa aagccatgat tgggaaccag atgccaagga tttttcctgc 2366281 tgcgtcttgg gcgccgaaag aaagccacac tgcaagacat acaagccagt tacagccgat 2366341 ggcggaaatg agaaccttgc caaagctcat atcaagcttt ccttgggcaa cggcaatcgt 2366401 tttttctaaa taaggacctg tttcagtcaa tccaaccaaa tgcccgaaaa agtaagcaac 2366461 aaacaatgcg ccgattaagt tcataattgt gacgattccc cagttaatcg ctaactcttt 2366521 tactgatatt tttctcgaaa ataacgccat cgcaactgac atcatattgc ctgtgatcag 2366581 ttcagcgcca gcgagaacga caaggatcag gccgactgga aatactgctg caccaatcaa 2366641 actggacagg ctcccccatt ctttcggaag atcgccaatt accctgatat caagcaaata 2366701 cccaagcgcg ataaatgcac cgcctaaaaa ccccagcaca agcagtgacg gcagcgggag 2366761 ctttattttt ttcatccctg cttcaattgc tgcttccgct atttcatccg gttttcgaaa 2366821 agccataata aaacgcctcc attacttctt cttttctcac agttatgcaa gaaaggcaat 2366881 aaaaaaggca gcactcaaat aacctgtgtc aaaccaggcg tttgaatgct gcctaacttg 2366941 tatgcatacc catacaacaa tatcaagcag tatataagat attgaaagag aatatataca 2367001 gttcgtgcat acattccatt gctttagcct tctataactg tagcaacatc atatcaaatg 2367061 tgacaaattt gtgtcaatga caaatatact agctttgcag agcttctttt tgctcatcta 2367121 tttttcggtc aaaaacaaat acagatacag cgatgttttc ctcaatttta atatcagaaa 2367181 acaaatggac tagcttagct cccataagtt cctccattcc ttccggtgtt tgtttggaat 2367241 aaaggtcttg aattaggctt gtccgggccg catgtaccat ctctcttcct tcaggcgtgc 2367301 gggcaataaa ctgctcgctt gcactcagat ttccgtatag tgttgaaact gccatgtttt 2367361 ctacaaatac agtatgaatt ctctcaggcc cttttccgaa caattctttg cgaagttttc 2367421 gaataatatc attgaattca tgaatttttt tagacatgct gattacccct tccgatattg 2367481 ccttataaag gcttttcccg gttcccctca ggacatttca cttggttaaa attttcctgc 2367541 catattgtat tataataaat atcacattat aataaaagca gtgttgatgg atttgtaata 2367601 ggatcttgtt atgagtctat cgttttataa aaatcaagga ttggtctgtt agtaagactt 2367661 gctagtgaac tattccgcca tgtgtgttta caccttctta gaattaaggg caggtgtatc 2367721 tatacatggc tttttttgac ttcttgaaag aaagatggag gggaatatga atatgatgga 2367781 cgttaagtcg atcagtgtcc gtgtagacgg aacagaaatt caagcacgag caggggccac 2367841 aattttagat attttaaatg aaaacggaat tgagtacccg cagatttgcc acgtaccaga 2367901 ggttgacccg attcaaactt gtgatacttg catagtagag gcaaacggca agctggttcg 2367961 ttcatgcgcg acggttgcag aaaacgggat gtctattgat ctttcaggaa atcgagtgaa 2368021 agaagcgcaa accgaagcga tggaccgcct tcttgaaaat catttgctgt attgtacagt 2368081 ttgcgataac aacaatggaa actgtacgct gcataataca gcggaaatga tggggatcga 2368141 gcatcaaaaa tacccataca cgccaaaaga agatccttct tgcgcggttg atatgtctca 2368201 tcctttttac cgctatgatc caaaccaatg tattgcctgc ggccagtgtg ttgaggtctg 2368261 tcaaaacctt caggtaaatg aaacactctc aatcgactgg gaacgcgaac gccctcgcgt 2368321 catttgggat gagggagttc cgatcaatga atcttcctgt gtcagctgcg gtcagtgtgt 2368381 aacagtatgt ccatgtaatg cactgatgga aaaatcaatg ctcgggcagg ctggttttat 2368441 gacaggcatt aaagaggacg tcatggaacc gatgattgat ctcgtgaaaa atgttgaacc 2368501 ggggtatggc agcatttttg ccatttctga agtcgaagcg gcaatgcgtg aaacgagaac 2368561 gaaaaaaacg aaaactgtat gtacgttctg cggtgtcgga tgttcatttg aagtatggac 2368621 aaaaggacgg gatattttaa agatccagcc tgtttctgat gctccggtta acgcaatttc 2368681 cacatgtgtc aaagggaaat tcggctggga ttttgtcaat tcaaaagagc ggatcacaaa 2368741 gcctttaatc cgtaaaaacg gagcctttgt ggaatcttct tgggaagaag ccctcgatct 2368801 tgtcgcaagc agattaggat caattaaaga gcagtacggt aaaggctctg tagggtttat 2368861 ttcttcttct aaaattacga atgaagaaaa ctacgtcatt caaaaactag cgcgtcaggt 2368921 atttgaaaca aacaacgtcg ataactgctc acgctactgc cagtctcctg ctacagacgg 2368981 attgttccgc actgtcggca tgggcggtga cgccggcacg attaaagata ttgccaaagc 2369041 aggcctggtc atcattgtcg gtgccaatcc ggcggaagga cacccagtgc tcgcaacacg 2369101 cgtcaaacgg gcacacaagc tccacggtca aaaactgatt gttgctgacc tgcgtaaaaa 2369161 tgagatggct gagcgatctg atctgttcat cagccctaaa caaggcacag accaagtttg 2369221 gctgatggct gttacgaaat atatgatcga ccaaggctgg cacgatcagg cgtttattga 2369281 tgagaacgtc aattactttg aagattataa agaaaccctt aaaacgtata cgcttgatta 2369341 tgcagaacgc atcacaggcc tttcaaaaga aaacatcatt caaattgctg aaatgattcg 2369401 tgatgctgac ggcacttgtg tcctttgggg aatgggtgtc acacaaaata caggcggttc 2369461 tgatacatca gcagccattt caaacctgct tctcgctacg ggcaactatc gccgtccagg 2369521 tgccggcgct tatcctctgc gcggacacaa taacgtgcaa ggcgcatgtg atatgggaac 2369581 attgcctggc tggctgccgg gatatcagca tattacagat gacaaagcac gcgctaaatt 2369641 tgaagaggca tatggtgtcg agattgatgg aaagcctggt ttagataata ttcaaatgct 2369701 tcatgccatt gaagaaggaa aaatgaaagc tatgtatctt gtcggtgagg atatggcact 2369761 ggtcgattca aacgcgaacc atgtgcatga tattttatca agccttgatt tcttcgtggt 2369821 acaggacatc ttcctgtcaa gaacagctca atatgctgat gtcgtcttgc cggccactcc 2369881 ttcacttgaa aaagacggaa catttaccaa cacagaacgc cgtgtccagc gattgtatca 2369941 ggcgcttccg acgcttggtg acgcaaaacc ggactggtgg attattcaag aggtggcaaa 2370001 ccgtttagga gcgaattgga attacagcca tccaagtgac attttctctg aaatggcgag 2370061 tctttctcct ctgtttgcca aagcaagcta tgaggtgctt gaaggctgga acagcttcct 2370121 atggggcagc ttcacaggtg aaagcacacc gcttctgtat gaagacggat ttaatttccc 2370181 tgacaaaaaa gcccgctttg ccctttctga ttggaccgag ccagcggcat ttccggagga 2370241 atatgacctt catatcaata acggccggat gctggagcat ttccacgaag gaaacatgac 2370301 aaataaatcg aaaggcatcc aagcgaaagt gccgaatgta ttcgttgaga tctcacctga 2370361 gcttgcacaa gagcgaggtg tttgtgacgg ttcgcttgta cggctcgttt ctccgttcgg 2370421 agcagtcaaa ttgaacgcgc tgatcacaga ccgggtacgg aaaaatgaac tctatttgcc 2370481 aatgaactcg acagacaagg agtcagcgat taacttcttg acgggccctg cagctgataa 2370541 acggacgaac acgcctgctt ataaacagac aaaggtccgc atggaagtgc ttggcggctg 2370601 tgaaacagcg ccgcttccaa aaacaaatcc gcgcaacaaa aaacggcatc cgcaaaacgg 2370661 agtcgaagca gaaagaaaat ggaaccgccc tggctatgta catctgactg attaaacgat 2370721 aggaggaaaa cgaatggcca ctccgattac gacgatcaaa aaagaaacaa aaacagctga 2370781 gcaaattaag cttgaaaaaa tagaagaact gaaagagctg ctggcggaaa atgaggacgc 2370841 cgtctctaaa acgatgacgt taatgaatga actcaatgat cttggaattt ttgatgcggc 2370901 aacaagcatg ctcagagcga aggaagacat tgccaagatt gcgcttggcc aagtttcccg 2370961 cgagcctgtc accaacctca tcaacacgat gatggccgcc ggaggcgcat tgacaaaagc 2371021 cgatcctgag tttacagcaa agcttttaga aagcgtaatg gctgggactg aacaggcaca 2371081 aagcttttta aaagaagaca agaaagtcgg gattctcgac ctgttaaaag caatgaacga 2371141 tcctgacatc aacagagccg tcgggttcgg ccttcagttt ttaaaaggca tgggaaaaga 2371201 acttcgagaa caataacaga aaaacagcca tctctgatga tggctgtttt tttattcgtc 2371261 ggcttcttcc agacgcttct tgtaaataag tgaacggtca gcgcaaaaga aggcaccggc 2371321 taaaaatacg caatccgcta aaaacatcgt cgatttctgg cctaatgtta agccttgatc 2371381 agggagaact gcgcctatat ataaaaaagt gctgactgca agcaatgtaa aagcaaaatg 2371441 cttgtagtct tcttttaaag atttcattct atttttgttc aaaagaatca cctgccagat 2371501 tcatagtata cgactattat aatataatcc ggcggcttac agagaaagta attctatcca 2371561 tttgttatat attttcaagc gcttggccga tatcttccaa caagtcttcc gcatcttcaa 2371621 ttcctacaga aattctgatc aagccgtccg taatgccgag ctcaagccgg cgttctctcg 2371681 gaatagaggc atgtgtcatt cttgcaggaa cagaaattaa gctttcaacc gcccccaggc 2371741 tttcagcaat ggtaaacagt ttcagatttc ctaaaaacgc atcaacccgt tcttcactgc 2371801 caatatcaaa ggagatcatg ccgccgaagc ccgctccttg cgtttttgca agctcatgtc 2371861 cgggatgatt tgaagaacca gggtaatata acgtttggac agcagggtga ttctcaagaa 2371921 agcttgcgat tttccgcgca ttttgatcga tcgcttccat tctgagtccc aacgttttga 2371981 ttcctctcat taacagccag gaatcttgag ggccgagcac gccgcctgtg gagttttgca 2372041 caaaatgcag ctcttctcca agctctttcg aagctgtcac aactaaacct ccgacgacat 2372101 cactgtgtcc gccaagatat tttgtcgcac tgtgcagtac gatatcagcg cctaaagtaa 2372161 gcggctgttg aaaataagga gtattaaagg tattgtctac gataagcaga acacccgctt 2372221 tttttgcgat atcagccatg agcgtcaggt cggtgatttt gagcaacggg tttgtcggtg 2372281 tttcaatata aattgctttt gtattagggc gaatcgcttt ttcaacttct tccctgctgc 2372341 tcgtatcaac aaatgttgat tcaatgccaa gacggttaag cacctttgtc atcacgcgat 2372401 atgttccgcc gtacacatca tcagtcaaca cgacatgatc tccgctgtta aacagcatca 2372461 taaccgctgt aatggcagcc attcctgagc tgaacgcata gcctgcttcc ccgctttcca 2372521 gttctgtcac aagtgcttcg agagcggttc gagtcggatt ggccgttctt gaatactcgt 2372581 agcctgtatg ctgccctgct ttcggctgct tgtacgtgct tacttgataa atcggcacgg 2372641 aaactgcgcc tgttttctca tcacctgtga ttccgccatg tatcatcaat gtttttttct 2372701 tcatatcaga tgcctccttc gtatatttgt ttgctgatat atcgatcgct gctgtcagga 2372761 aatactgtga caatgttagt tccagcggat gcttttttcg cttcctccaa tgccgcataa 2372821 agcgctgcac ctgaagagct tccgatcagc aggccttctt tttctgccgc ttctttcaca 2372881 agtctaaacg cattctcatc tgttacggtg tagatctcgt caaaatggct cttatccata 2372941 taatcgggga taaactccat gccgatgccc tctgttttat gagcgtgggg ctctcctccg 2373001 tttaaaatcg agcccaccgg ttcaacaatc accgttttga ctgctggatt tttttctttt 2373061 aagaaggaag ctgtccctgc gaatgtgcct cctgatcctg cccctgcgac aaatgtatga 2373121 atattcccgt caagcgcttc ccacatttca ggtccaagcg tcttatagta agtcgatgga 2373181 tttactcggt ttttaaattg caaaacgcaa taagaatttt caatttcagt ctccagctga 2373241 atggcttttt gaatggctcc ctgcattccg tcttgacgcg gtgtatgaat gattgatgcg 2373301 ccaagcgctt gcataatttg ctgtttctct ctgctgaaat gttcagggac acagaaaatc 2373361 gctttcagcc catattttct ggcacttaac gcaaggccga tccctgtatt gcctgccgta 2373421 gcttctataa tcactccgcc gggtttcact ttgcctgaat cgagcgcgtc acgaatcagc 2373481 atatctccca gtctgtcttt gatgcttccc cctggattca tcatttcaag cttggcatac 2373541 accgcgactc cttctggaac atcaaagttc ttcaagcgga gaagcggtgt attcccaatc 2373601 agctcggtaa tgtccgtaat cactgtcata tatgtcctcc tccttaatag aggttgtttt 2373661 tagagaaaaa cggaggagaa cgttctcccc gttttaatga attcgtttga tcacctttaa 2373721 cacaagctct gttgaatgaa cagccgcctg ctctaaaaat tggtcaaatg aaacatgtga 2373781 ttctttgcct gcgatatctg ataacgctct gatgacgaca aacggcgttt taaattgatg 2373841 gcatacttga gccactgccg cagcctccat ttcaaccgcg tacagatcag aaaatctcgc 2373901 acgcacctct tcaacccgct tcggatcgtt catgaaagaa tcgcctgttg caatcgttcc 2373961 ttttgcaacc tgaatgccgt cgagttcaga taccgcttct tcagtgatgc tgatcagctt 2374021 ttcatccgcc gcataagcag ccggaagacc cggcacttgg ccgtattcat agtcaaaagc 2374081 cgttacgtct acatcatggt ggcgaacgtc agtggaaatg acgacatccc ctacattcaa 2374141 tgtatgatga aatccgccgg ctgagcctgt gttaatgaca taatcaggct tgtaacggtc 2374201 aagcagaagc gtcgtgctga tagcagcatt tacttttcca attcctgatt ttaaaagaat 2374261 cacttcagtt ccttcatatt cgcctgttgt aaattcacag tgtgcgatcg tttctgtttt 2374321 tgcattttca agtttgtttc ttaagatggt aacttcctct tccattgctc cgatgactgc 2374381 tagtctcatc tattcacatt cccttcactt taccgtttga tcgcctccat tatccacacg 2374441 aagtcgtttt gctgagtgaa tcggactgca aaaccttcag ctgtaaacat ttctttcaac 2374501 gcatccaatg taggataatg ctctgtctct aaatcatttg caagctgata aaagccttga 2374561 gaacgggctt tatcgatagc ctgttgatac gcttgcgcat tttcaaagac ggtatcggca 2374621 aacactattt tatcatgcaa gtgaaggtat ttgccatatt gctttatggc agcccgcttt 2374681 tcttcgtcag tcaaatgatg aaaagcatat gaactgacaa tcgtatcagc ctgaaatggc 2374741 ggctcaggga atgtcaggaa gtctccatca acgatttccg tcctgcctga gagcttgtca 2374801 gaagccagtt tacgcattgc tggagaaggt tcgattccaa atacagtttt gcctgcatcg 2374861 agcagcttag ctgtcaaatt cccggtcccc gggccaaatt ctaacacatg cgttccagat 2374921 tttctgacga tggcatcaag gatatgatcg tagcctctga acgcttcttt atactgaata 2374981 tctaaacctt gtactgtttg atcataagtt gctgcccaat cttcaaagag agggataaat 2375041 tcacggccca tatttgtcac actccatatt taataattcc tataagtata ctatggatta 2375101 atgatggaac agttcctata ataccacata ttctgaaaag caggtactaa aacactttgt 2375161 gtattttatg ccatctcata ttgcgcattg accgcaaaaa agcttatact tcatatgact 2375221 tgtgaaagct ggagggtcaa gacatgaatt ttcaattaga tctgattaaa gacaaagtgg 2375281 aattttttga agcggcttca ttgcaggagc ttgaaaagaa aatcaataca caaattgaaa 2375341 acaataaagc catcatgctc cgggtgaaat ctgtttcaca ccaaactctt gtggcagaag 2375401 gaagaatatt gtacagcgcg gtggttcatt tctcagctga agcctaaaac aaaagcagcc 2375461 ggttttaacc cggctgcttt tgtttatttt agcttttcta cttttgtcgg cttccagcct 2375521 ttttcatcga cccatgtaat cgtgacttga tatttattcc cagtcgcctt gtccaaaatc 2375581 ttgcctttgg catcctgagg gctgccgtta tttccaagcc agagcaccgt catgttatct 2375641 gttgagacac cagttgcgta cgaaatggct ttcagcatct cagcccagtc ttgtgagctt 2375701 gaatcataag tagcggcatg ctcgccagtc tgctcagttc cgactgcttt ccagtcagga 2375761 ttttcatacg ttttttccac atcgctcgat gagccgcctt ctgttacttt tgcatcttta 2375821 agcccgtcac cggctgaatc tgagcttgaa tctgaatcag agtcatcttt tttagaagaa 2375881 gaatcatctt ttttggaatc agagtcagaa gacttctcag aatccttttc gctgtcagat 2375941 gtatctttct tgctgtcttt tatatcctca tccgatttct tttccgtctt tcctgaagcc 2376001 ggagattcct gtttttgcgc cgtttcagaa tccttgctga catctttgct agaaggactg 2376061 ttaatgaaga gattcgctgc tactacgaca attagtatgg atacgattgc gattaaaatg 2376121 ttaagcacta aattggcttt tctgcgttta tcacgatttt cataacgaga ttgattattg 2376181 ctcaataatt ctgcactcct ttatccctct tggctcagca tatattttaa catgtgctga 2376241 gaagttgttc tatttctgat tgatttcaat ttcgtgtact tttttaacaa tatcataaaa 2376301 caccgaattt gtcagagcct tatctcccgg tgtatccatg tgtaaaacaa ctagagcgta 2376361 tttcggctta tccgcgggaa aatatccggc aaaccatttt tcgtagagcg tttccttctc 2376421 ttttgaaagc ttgcctgtct gggctgtgcc cgacttccct gctacagtat acggaagatc 2376481 ttgaaacctt ctgcccgttc cggaaggaga ttctactacc cgccgcagta ttttttgaag 2376541 ctgctgtgac gtatatttgt ctatcgtttc ccctttgagc ttctgatctt taaacgtaac 2376601 gagcgttgtg ccgttcttat actcaatttg ttcggcaatt ttcacctgcc gtttttctcc 2376661 gccgcgggcg attgtcgcca tcatattggc tacctccagc ggcgttacct ttacattttt 2376721 ctgcccgatt gctgtttgcg caatggcttt tttgactgat ttgtcttttt catcccccca 2376781 aatcacgccg cttttttcgt tatacagctg gcggaaatcg gtttcgtggt acagttttcc 2376841 ctcccagcct gcccgatcag tgagagccag cttctcggac atatcttcaa taaccgagct 2376901 gtcttttttc attaattgtt ctgcaagact cgtaaatgtg taattacagc tttgggcaaa 2376961 actttcatca aaagacaagg tgcctttgtc gtcccccggt tccccgtaca ggtttaaatt 2377021 gcaattaaag gtttgactag gcttcaccat attattttcg attgcagctg cggcaatgac 2377081 tgttttaaaa actgatccgg gatagattgg cgtcagcata taattttgaa gtgtgttttg 2377141 ccgggacacg tctgcatctg gtttgcttac aattcccaga acactgctat tttcgatgtc 2377201 cagcagcaca gctcctccct ttttcagccc ctgttcatcc aatacctcct ccatcgcttt 2377261 ttgaatgctt tgatcgatcg ttgttttgat ctggagcgga taaaatgtat tggcttcagc 2377321 tgtatatttg acgtccatgc caaacaaagg gtttcctttt ccgtccacat gatataaaag 2377381 ctttgtgtct tgttccggaa gcaaaaactc gtcaaatgtc cgttctaaac cggttgttcc 2377441 gatttctgtt gtaatcggaa ggctctcctt gtcaggatat ttcttgcgaa gcagcgccgg 2377501 atcttggttc gtgctcccta tcgtatgtga agcaaggctg ggcttgtctt cattctccat 2377561 atatacgccg taaatgccgg gatatttcaa agaattgatt tttgtgatag attgttttga 2377621 aagtgttttg attttctttt gctgcaaaat gaccggtttt tttgcctgac ctagtgtctg 2377681 gcgcaaatca tcttcagaca tgccgaggat gtccgcaact tttttgatcg gccaatcctg 2377741 cgtcagcaga aaagggaaca aaacaaccgc aggctcgctt tgtcctgtca gcgcccgccc 2377801 gtttcgatct aaaaaagagc ctcttccatc tgaaatgagc acttcctccg tccgctgttt 2377861 cacactttct tgaatcaaat taattttctt tttagaaaat gattctgtga aaaacagctg 2377921 gatttctgca agtctcagca gaagcagaaa aaatacaatc aaaaaagcga tgactgccag 2377981 cttcattcgt ttcgatatct tcataaaaaa acacctcacc cacattgtgg acgaggtgtt 2378041 tcgctgctaa acagatatta tgaaattttc acaattttca cgagcatttc tccgcccggt 2378101 gtttgtactg tgacttcttc atctactttt ttgcccaaga ggctttttgc gatcggtgaa 2378161 tcgtttgaga ttttcccttc aaacgggtca gcttccgcgc ttccgacgat cgtatatgat 2378221 tcttcatcac cgtcaggcag ttcgacgaaa gtgacggttt tacccaaacc gacaacgtta 2378281 gagccgccgt catcttcaat gattttcgca ttgcgaatca tattttcaag agtcgtcacg 2378341 cggccctcta caaatgcctg ctcttctttc gctgaatcgt attcagagtt ctcggaaagg 2378401 tctccgaagc ttctcgcaat tttgattcgc tctactactt cttttcgttt aaccgttttc 2378461 aaatattcta attcttgttc aagtttttgt tttccttctg cagtcatagg aaaaactttc 2378521 tcttgtgcca tgtcccttca ctccttctgg ttgtccctca acatcttcga ttatgtatga 2378581 gagcataaac taaaaaatac aagaatgaga acacagggca gtcctcgttc ttctctccca 2378641 tataggtact gtttatctta aactgaatcg tgtcgttctg caaatatttc gcgtttataa 2378701 acagggaaag aagggaattc gcacattccc ttcctgccta tacataatat ggtcagagtt 2378761 atttatgtct atgctatggt attacaaaat cgcgttttgt tcaagaatgg tttgaatttt 2378821 tgtgaccatc agatcaattg cgacgtgatt ctgaccgcct tccgggataa taatatcagc 2378881 gtatcgtttc gtcggctcga cgaattggtt atgcatcgga cggaccactg acacatattg 2378941 ttcaatgaca gaatcaatag agcgtccgcg ctcattaata tctctcataa tccgtctgat 2379001 gatacgcaag tcagcgtccg tatcaacata aagcttgata tccatcagat cacgaagcct 2379061 tttgtcttca agaacaagaa tgccttcaag gataataaca tcctttggct ctacgtgaac 2379121 cgtttcttct gaacgtgtgt gaagcttata gtcataaatc ggcttttcaa tcgggcggta 2379181 attcaataga tcttgaatat gctcgattaa atagtcatta tcaaacgcaa gcggatgatc 2379241 atagtttgtg ttcagccttt cttcaaacgg aagatggctt tggtctttat aataaaggtc 2379301 ctgctggatc attaaaattg agtgtccttt aaactgttca taaatggacc gtgtgacact 2379361 cgtttttcct gaaccggaac ctcctgcgat tccaatgact actggattct tacccatggg 2379421 ctgttacttc ccctttctca tcatgttgct cggataaatc tttttgtcta gtttgaattt 2379481 gacaatttgc aggggatggc gggcagcatc tagctcattt ccgtcttcgt cccaaatggt 2379541 ttcaatcgta tgtgtaaagt tttcgatttc tggaccgaaa aattccactt cgtcgccttt 2379601 tttgaagaaa ttgcgctgct gaagcgtgac catttgtgta tcttcatcat aattcagcac 2379661 taagccgaca aaatcatatg tcgttttctt ggcgtgttcg ccgaacattt gctcttcata 2379721 gcctggcgtt ccttcaaaga aagctgtcgc agtgtccctg ttggcgcact tatcaagctc 2379781 ttcaagccat tctttttgaa tcacaaagtt ttctggatca gcgcaataag catcgattac 2379841 tttgcggtat acgctgacaa cagttgctac atagtgaatg gatttcatgc ggccttcaat 2379901 ctttaagctg tcgatcccca tttcaatcat ttttggaatg gattcaatca gcttcaaatc 2379961 tttcgggctc atcgcaaatg gtgcatcttc ttcaccatac aaagcaacgg cgttggcacc 2380021 gtctgtttgg tagagatcat aatcccagcg gcatgactgg cagcagcctc cgcggttgga 2380081 atcccgcgct gtcatgtgat tgctcagcac gcagcggccg gaatatgcaa tacacattgc 2380141 gccatgaatg aaggattcga tttcgatatc taccttttct ttcatttctc tgatttcaag 2380201 agcgctagtt tcacgtgcca gcacgacgcg gtcgagacct tcttccttcc agaactggac 2380261 agccttccag tttgaaagag actgctgtgt gctcaagtga acctcaacat tcggcgccac 2380321 tctgcggcat gtttcaataa taagcggatc tgccacaata ataccggcaa cgttggcgtc 2380381 tccaagcgct tttaaatagt cttcaagccc gtccatgttt tcattatgag cgaaaatatt 2380441 cgttgttacg tagatcttcg cgccatattt ctttgcgaat tcaacgcctt ctgcaatttc 2380501 ttcgatcgta aagttatcgg cattcgagcg aagcccgtat tcctgtcccc cgataaagac 2380561 cgcgtccgct ccgtaatgaa cagcgatttt cagcttttca agattacccg caggtgcgag 2380621 aagctccggc tttttcgtaa tcacacgctt tccattaacg attgtggata ttttatcatt 2380681 tacggcagtc atagcttaac ctccttttga ttaataaacc gtttccttga agaagaatcc 2380741 ggtatcaatt tttctgttta ctggctggat gctttcaatg cgttcgatcc agtcttcttt 2380801 tttcgcttcg tattcgtcac ggttttccac gcacaaatca attgcttctc tgtacatttt 2380861 ggtgacttct attaggtatt caggcatttt caaaacacca tcgattttga aagaatcaat 2380921 tccggcatct atcaattcct cgagctcatc aatgatgcac acatcgttcg ggctcatgat 2380981 gtgagtgccg ttttcatctt cgaaaatcgg atatttatta tcgcgttctt tatcgtgtaa 2381041 aaacatgcct gattcttttt tctttctttc aatgtccatg actttgccct gatattcaaa 2381101 atagtttcca atcaaagaac gcttcgattg gaacatgcac gtcattccat gcacctggat 2381161 ttcaatttcg acttcagcat tttctttaat ctcaacaatg ctgtccatgt ttaattctct 2381221 ggcaagcaca gaacgcgccg cacccttgcg tccccagtag ttgcatgtat aatagttggt 2381281 gcctgtcgtt tctgtgctcc aatgaagctt cagatcaggc gcagattcac gggcagccat 2381341 cagcacggca ggatcgccga ataccgctgc atcgacaccg gcttctgcta agaaagccag 2381401 atattcgcca agctcaccca ctttatcatt atggaaaatt gcatttacag caacgtatac 2381461 ttttgcccct tctttgtgag caatctctac ggcttttgtt acatcttcac gagaaaattc 2381521 tccggctaat ctcaagccgt atctctgttc cccaactaaa aacgcagttg ccccagcctg 2381581 tatgagcggc aaaatgtccg ctgtactcgt cggcgtcact aagagctctg gttttttcat 2381641 gacgttcacc tcttcttttt actaatcgca agtccgtccc cgacaggaat aatcgcagtt 2381701 tgataatccg gatgattcat cagccaatga ttatattcat caattttggc tacaagcctg 2381761 cgccttctct tcggttctat tttgctgtaa tcctctgcca ccagaccttt aaacagcacg 2381821 ttgtctgtta taatcacccc gtccggtgaa agcatcggtt catataaatg aaaaaagttt 2381881 tgatactgac cttttgcagc gtcaataaaa atgacatcgt aaggcgcggt tacatgaacg 2381941 gcgtcggcta attcaagcgc atctccgtaa aaaacatgaa tccggtcatc aagctgaaat 2382001 tccttgatat tgtttaccgc ttcttcatgc cgtttctcat tgcgttcaat tgtatatatt 2382061 tcagcagacg gcagttccag agccattcga atggctgaat aaccaatggc cgttccgatt 2382121 tctagtattt ttttcggctg tttcacagac aaaatttgaa gcagcacctc catgcccgct 2382181 ttttccataa tcgggacatg atgttcttct gcatatgctt caagtctctt cacgttatcc 2382241 ggccgaggct ttaataatgc ttctatatag tcatttattt gttcataccg gtcagtcact 2382301 acaaacagcc tcccgttcta aaaaggagtg ccccagtctt atgcgcagga cactctctga 2382361 atacatcatg atacatcggt aaacaacccg atatatttta tcataaaacc ttgcggaaag 2382421 cgaacaaaag gagagctttt tgctctcctt ttatttctca ttttttgagg aaatgtattt 2382481 ttcttttgct ttattatgct cttttagcgt ttttgtaaat acgacctcac catttgattt 2382541 ggccaagaaa tacagatagt ccgttttatc cggatgcagc gctgcttccc atgatgacat 2382601 gccggcattg gcaatcggcc ctggcgtcag ccctgtgttt ttatacgtat tgtatggtga 2382661 atcgatttcc agatccttat aaagaacccg atctttatgc ttgcctgccg cgtacaggac 2382721 ggtcggatct gtttggagcg gcattttctt tttcaggcgg ttataaaaga cgctcgcaat 2382781 tttatggcgg tcggcttttt cagtcgcttc ttcttctatc aaagaagcca ttgtcagcag 2382841 cttatgcaca gaaactttgt ttttcttcat ttctgattta tatgtttcca cataagaatt 2382901 tgtctgctta atcattgcct tgataatgtc ttcaagtgat gtgtccggat cgttaaaagg 2382961 gtatgtagcc gggaataggt acccttcaag cgggtgctta atgtttttat tgaaaacatc 2383021 atttgtcaca gtgtccggga attctttctt cagctgattg ataaatgttt catcgtccag 2383081 cttcgctatg acttgttttt tagagtattt tgtttcatca gcaatagcag ccgcgatttg 2383141 ggtcagctgt gctccctcag tcactgtgat ttgaaaagcg taacctgtag ccccgcttgt 2383201 cagcttctga ataatggcat ctaaatccat acctttattc agatggtaga atccggcctg 2383261 aaacccggaa gcacctttat atttcacata gtactgaaac gccttctcgc tttttatgac 2383321 atcatttttc tttaatatcg atgcgatggc tgaaacagac gaaccgctcg gaatgttaat 2383381 attaactgtc gttttactgt ctttttcaac aggttcaagc aatgatttcc catataaaaa 2383441 tgccccgcca atgatgagaa acagcacaac aatggaagac agtatgattc tttttttatt 2383501 aaaaaacgat tttttttgct gattgatata cattaggtct cctcccatca gctcttatac 2383561 tacatgattc attgtatttc ggcaatttat tacaaaaaga ggcctgcata aagcagaaaa 2383621 aagccggagc agtatagctc cggctttggt ttggcgcgat gttttactct tcgtcttcgt 2383681 ccgctaagaa tgtgtttagt gtttcttcga tcatatccca ttcttcgtca gtttcaatcg 2383741 ggaatagctc accgttttca ccgtcttcgt ttggcgtgaa gctggaagca agaatttcta 2383801 cttcttcgtc atcttttgat tcgattggat agtacaagac ataagatttg ccaaactctt 2383861 cattttcaaa tgtaaacagc acttcacaaa gctgttcatt tccttgatcg tcaacaattg 2383921 taatattttt ttcgccgtgt tccattttct tcacctctgg ctttaattta agctgtcaag 2383981 atatccttgt aaaatcataa cagccgccat tttatcaatg actttttttc gtttttgcct 2384041 gctgacgtca gctgcaatca gcattttttc agccgccatt gtggtaagac gctcgtccca 2384101 cagcacaaca ggaacattgt acgttgtttc aagcactttc gcaaatgttt ggctggcttc 2384161 gcctctcggg ccgactgttc cgttcatgtt cttaggaaag ccgagcacga ttttatctat 2384221 agtatagtcc tttatcagtt cagataaacg ggataaacca taatcgcctt ctgcttcatt 2384281 tatctttatg gtctcaatgc cttgagcagt ccagcccatt tcatcgctca gagctacacc 2384341 gagtgttttg gttcctaaat cgagtcctaa tattctcatt ctttatttac gcctctttat 2384401 gctgttctaa ataagacttt accaattcct cgattaattc gtctctttca agtttgcgaa 2384461 ttaaattgcg agcgtcacga tgcctaggaa tataagcggg atcacctgac agcaagtatc 2384521 cgacaatctg gttgattgga ttgtagccct tttcctgaag cgcgtcatac actgtaatca 2384581 gcacctcatt tacgttagtc tcagcagaat catcggagaa attaaatttc atcgttttat 2384641 caaacgagct caccgttttg cacctctttc ccaaattcgc aggcaaagtt cagcctgggg 2384701 tcctaatctt accatcattc tacactacat gggcgaatta taaaacggat ttcacccaat 2384761 cttctacaga agccaaagct tcttctaatt tttccggctg tttaccgcct gcctgcgcca 2384821 tgtccggacg gcctccgccg cctccgccgc aaacttccgc agcttgttta accagcttgc 2384881 cggcgtgaag tcctttctca atgaggtcct ttgtgactcc ggcagagata ttaactttat 2384941 cgttttgtac cgcaccaagc acgatcaccg cagagccaag ctttgctttg agttcatcga 2385001 ccatagtgcg gagatgattc atgtcttttg catttacttt tgccgcaagc acgtttacgc 2385061 cgtcaacttc ttttactttc gacaggattg ctcctgcttc cacgttgcct agttttgcaa 2385121 gaagagattc attttctctt tgtgcatcct tcagttcagc ctgcagagcc gcgacccgtt 2385181 tcggcacttc tttgatattt gttttcagct cgtcagcggt ctgcttcaat acagaaatct 2385241 ggctgttcat ttcgacgtaa gcgccttgtc ccgttacagc ttcaatccgt cttgtgcctg 2385301 ctccgattcc ggattcagaa acgattttaa acaagccgat ttctgctgta tttctgacgt 2385361 ggcagccgcc gcacagctct aagctgtaat ctccaacttg aacgacacgg acaatatcgc 2385421 catatttttc gccgaacagt gccatcgcac ccatttcttt tgcttcagcg atcggtttca 2385481 aatcaatgct gaccgggatg ctcgcccaga tcttttcgtt tacgattctt tcaatttgtt 2385541 cgagctcttc ttttgtcact tggccaaagt gcgagaagtc aaaacgaagg cggttttccg 2385601 ttacaagaga gcccgcctga ttgacatgag ttccaagaac atcttttaga gcctgatgca 2385661 ataaatgcgt tgccgtgtgg tttttaatga cgccgcttct catatggtct tcaacttcag 2385721 ccgtaacatg caggcctttt tgaacagtac cgctctccac aacaccttca tgcacatgct 2385781 ggccgttcgg cgctttttga acatctttaa ttcttacaac tgcctgctcg cttcggagat 2385841 agcctttgtc gccgatttgg ccgccgcttt ctgcatagaa cggtgtttca tcaagaatga 2385901 tttgaacgct ttctccttca tgagcctctt cgattaattg gccgtcctga agaagcacaa 2385961 tgatattggc atcagctttg gtttgagagt agccgacaaa tgtgctttca actgtcacgt 2386021 cgcgcagtgc gccgccctgc acctgcatgc tgccgacatc ctggcgggcg tttcttgccc 2386081 gttcacgctg ctggttcatt tcctcctcaa agccctcatg gtcaaccgtc atgttctcgt 2386141 cttctgcgta ttcttcagtc aattcaaccg ggaatccata cgtatcatac agtttaaaca 2386201 catcagcacc tgagataacg ctgctgccct tgtctttttc ttttttgatc atttctgaca 2386261 ggatcgcaag cccttcatta agggtctcat ggaagcgttc ttcctcggtt ttaatgactt 2386321 ttgcgatgaa atccgctttc tctttcactt caggatagaa atcagccatg atttctgcga 2386381 caaccggcac taaatcaaac atgaacggac gatggatgtt gatcgttttg gcataacgca 2386441 cggcacggcg taataagcgt cttaatacat agccgcggcc ttcatttgac ggcagcgcac 2386501 cgtcactgac agcaaaggca accgttctga tatggtcagc aatcacttta aacgcagtgt 2386561 ctttcacatt gtctttgcca tatgtttcac cagaaatcga ttctgttgct ttaatgatcg 2386621 gaacaaacaa atcggtgtca aagtttgtcg gaacattctg gatgacagac accattcttt 2386681 caagacccat gcctgtatca atatttttct ttggaagcgg tgtgtacgtg ccgtcagggt 2386741 tatggttgaa ctctgagaac acaaggttcc atacttccag gtaacggtcg ttttccccgc 2386801 ctgggtaaag ctccggatct tctggatcat taccgtatgc ttcaccgcgg tcgtaaaaga 2386861 tttccgtatt cggtccgctc ggcccttcac cgatatccca gaagttccct tccagacgga 2386921 taattctttc ttcaggaata ccgatttttt tcgcccaaaa ctcatatgcc tcttcatctt 2386981 caggatgaac cgtaacagag agaagctctt tgtcgaagcc aatccacttg tcgctcgtta 2387041 aaaactccca agcccatgta atggcttctt ctttgaaata atcgccgatg gaaaagtttc 2387101 cgagcatttc aaagaaagtg tgatggcgcg cagttttacc tacattttct atatcgtttg 2387161 ttctgatcgc tttttgagcg tttacgattc ttggattttc cggcacgaca cggccgtcaa 2387221 aatatttttt cagcgtcgca acaccgctgt tgatccaaag cagtgaagga tcctcatgag 2387281 gcactaatga cgcgcttggc tctaccgcat gtcctttttc tttaaagaaa tccaaaaaca 2387341 tttgacgcac ttccgcagaa gttaagtgtt tcattgtatt tcctcctcta taaaaatcga 2387401 aattctcttc agtgacagca aaaaagccct ccccctatgc aaaccaacgt ttacacaggg 2387461 acgagagctg tctcgcggta ccaccctgat tacgggcatt catgcgcccg tcacctttaa 2387521 ccctgtaacg caggataagc ggcagtgatt aactgcactc aggattagct tcctccgatc 2387581 ttctgataaa gctcctttca gcttatggag cttctctctt taacagggct tcggcgtact 2387641 cagatccgtc actcgagatt cgtatgtatt ctacgagaaa ttatagacaa gcggcacgcc 2387701 gatgtcaatg ctccgtcctc atccgcaaaa aatggatcat cattactttt aaaacagccg 2387761 tcgcaggaac agccagaatc atcccgacga tacccgcaag ctcccctccg gcaaggagtg 2387821 caagcatgat aacgaccgga tgcattttaa ggcttctgcc gacaatgaac ggactgagga 2387881 tatttccttc cataaactgc agaataaaca ccgtaatcac cacaacaaga accgccttga 2387941 ctgagatcgt catcgcaatt aacaacgcag gaacagctcc gatgaaaggg ccaaaatacg 2388001 ggatgacatt cgttacccca gagataaggc caagtatcag cggatacgga agcccaaata 2388061 cccagaacga aatgcctgca atcacgccaa gaatcaagca gaccaaaagc tggccgcgga 2388121 tataatcgcc aagcgaatca tccacatccc gcaaaaaggc gctgccccgc tttctccacg 2388181 acttcggagt caagtaccat actgtctttt tcattaactc aatgtccttc accatataaa 2388241 acacgagaaa agggattgtt gcagcaatta agaagtaatc aagcacattg cggatcccgc 2388301 tgatcgcacc ctcgatcgtt cccgcaaaaa acgcctccgt ctggcggatc attttatcta 2388361 tacggtgatg cataccatca ggccagtcat ccgtatggtt atgcacatga agaagaagcc 2388421 cgttatacgt ttcggcaaac atgggtatat tttctgacaa atccgtcagc tgcacgatta 2388481 aaacaggcac ccctttatac aacgcccagc caatcccgcc aaaaaaaaga acataaatga 2388541 ccaagatgct caaagtccta ggcaatcctt tgccatgcag ccattctgtg accggaagca 2388601 ataaataaga tataaaaata gaaatgatca agggaataaa gatcgttttt atgacgagcc 2388661 aaaagggtga ccataacata tcaagcataa aaaagacata gactgttaac agaaccagca 2388721 aacaaatagc cacccacaac aaaagctgca ccggtttttg gagcatctgc tttcacctca 2388781 cctatatctt ttgaggttta caaggaatta ttctttatgt ttctttagtc agtcagaagt 2388841 catggacatt ttttcacttt taattttcag aaaagtttga tcatttactt tttggtcaaa 2388901 ttttctgata ggaggattgc gatgatcaca tttcaaaatg taaacaagca ttacggagat 2388961 tttcacgtgt taaaacaaat taatcttcaa atcgaaaaag gtgaagtcgt tgttatcatc 2389021 ggcccatccg gttccggtaa aagcacattg ctcagatgca tcaacagact tgagtcgatc 2389081 aatgagggag tgcttacagt aaacggcacc gccattaacg acagaaaaac tgatatcaat 2389141 caagtgcggc aaaatatcgg gatggtgttt cagcactttc atttatatcc gcataaaaca 2389201 gtgctgcaga acatcatgct ggctccggta aaagtgctta gacaatcacc tgaacaagca 2389261 aaggaaacgg cgcggtacta tcttgaaaaa gtcggcatcc cagacaaggc tgacgcctat 2389321 ccttcccagc tttccggcgg gcagcagcag cgtgttgcca tcgcaagagg actggcgatg 2389381 aagccggagg tcatgctgtt tgacgagccg acatcagcac ttgatcctga aatgatcggt 2389441 gaggtgctag atgtcatgaa aacactcgcc aaagaaggca tgacaatggt tgtcgtgaca 2389501 cacgaaatgg ggtttgccaa agaagttgcc gaccggattg tcttcattga cgaaggaaaa 2389561 attttagaag aagcagtgcc ggctgaattt tacgcgaacc cgaaggaaga acgggcccgc 2389621 ttattcttaa gccgtatttt aaatcattaa aacagaaatg ggggagcttg tatgaaaaag 2389681 attttttctt tagcattgat ttctttattc gctgtcatct tgcttgccgc ttgcggcagc 2389741 aagggatcaa acggagaagc ctcaaaggag agcaaaaaag atacgctagc cgccattaaa 2389801 gacaatgaca aaattgtctt cggcgtaaaa acggacactc gactgttcgg tcttaaaaat 2389861 ccaagctcag gtgagattga gggttttgat attgatattg ctaaacaaat cgctaaagac 2389921 attttaggtg atgagaaaaa agctcaattt aaagaggtca cctcaaaaac aaggattcct 2389981 atgctgcaaa acggggatat cgacgccatt gtcgccacaa tgacgatcac tgaagaacga 2390041 aaaaaggaag ttgacttttc tgatgtctat ttcgaggccg ggcaatcgct tctcgtgaaa 2390101 aaaggcagca aaatcaagag tgtcgagaat cttggcaaag gctcaaaagt tcttgcagta 2390161 aaaggctcca cctcctctca aaacattcgt gaaaaggcgc ctgaagcatc tgttttagaa 2390221 tttgaaaact acgcagaagc ctttacagcc cttaaatcgg ggcaaggcga tgccctcacc 2390281 acagataatg caattttata tggaatggct gatgaaaata aaaattatca attaacagga 2390341 aagcctttta cagatgagcc ttacgggatc gccgtgaaaa aagggcaatc tgctctcgcg 2390401 aaagaaatca acgcttcact taaaaagatg aagtcggatg gcagatacga tgaaatttat 2390461 aaaaaatgga tcaaagaaga cccagctgaa taacaaccat cccgggatga gcaggcgatg 2390521 ctcatcccaa tttgataagg agtgaatagg cagatgaatg tgtcaattct tttcgataac 2390581 ttcagcatgt atatggacgg tttttaccat accttgctcg caagtgttat cgcgctggcc 2390641 ggcagttttg tcctcggcgt tgctgtagcg gttatgagaa taacagtctt taagccgctg 2390701 caatggctcg ggaccgcata tgtagaattc atccgcaaca tccctcttct tttaattacc 2390761 tttgttttct atttcggact tccaaacgca ggcctgaggc ttgacggttt tcaagcggga 2390821 acggttgctc tcaccattta tacctctgcg tttatcgctg aagccatcag agcaggcatc 2390881 cagtctgttt caaaagggca gatggaagcg gcacgctcgt caggctttac ctacagccaa 2390941 gccatgctcc atatcatttt gccgcaggca atcaaaatcg tcattccgcc tttaggcaat 2391001 caatttttaa acttagtcaa aaactcttcg attcttgggg ttgtggccgg attggatctt 2391061 atgtaccaag ccgatttagt ttcgtcgagc acactcgttg tatttgatgt ttatattttt 2391121 gtggcgcttt tttacttagt gctgacgatt ccgcttagca tcggtgttaa ctatctggaa 2391181 aaacggctgg aaaaaagcta ttgataagga gtgagttaca ttggatttca tcggtgctta 2391241 ttcacaggag catttagcgt ttttatggga tggctttctc gtcaccttgt acgttgcttt 2391301 catctccatc attctgagct ttttcttcgg tttaatcgca ggcaccctgc gttatgcgaa 2391361 agttcccgtt ctttctcaat tgattgcagt tctcgttgaa acgatcagaa acctcccctt 2391421 gctgttaatt attttcttta cgttttttgc ccttccggaa attgggatta agcttgaaat 2391481 tacagctgct gcaattacag cactaacgat ttttgaatcc gctatgctat ctgaaattat 2391541 ccgaagcgga ctgaaatcaa ttgacaaagg acaaattgaa gcggcgcgct cctccgggct 2391601 gagctataca cagaccctgt tctttatcgt tatgccgcaa gcgcttcgcc gcatggttcc 2391661 gcccatcgta agccagttta tttctttatt aaaagataca tcgctcgctg ttgtgatcgc 2391721 cctgcctgaa ctgattcaca acgcgcaaat tattaacggc caaagcgctg acggcagtta 2391781 ttttttcccg atctttttac ttgcggccct tatgtatttc gcagtcaact acagcctttc 2391841 actcgcagca agacgcctcg aggtccggca aacatagaaa aggatactct ttggagagta 2391901 tcctttttgc attaaaacat tttcgtaatt cttcttctca tccgcttcat gcttcgatta 2391961 ttcagcatgt cagattgagt cgccattcgg tacacgagag ctccggctcc cattgccaaa 2392021 agagaagtca tcgtccgatt catcctgcgc atctcctttc atgattaaaa attgatgctg 2392081 cgttcatcct cagaaaacaa atcatccaag ctgcttaacg ttccgtcttc ttccacctga 2392141 tgagttgcaa tcttcccttt cgccactgtc agttcaataa aacagcccca gcaataatat 2392201 tggttcacgc cgattttgcc gatatcctta cttttgcaat tcgggcatat aagcatacct 2392261 cacacctcta tccgttcaga acgatctcgt ctttccgcac ctcgacaagc gaatccgctc 2392321 tttggatctg gcgcttgctt cccgccaggt cagaaaagaa accgtccgag agttcatatg 2392381 ctacgattat gcccctgtcc aaacaaaagt atacatcttc cagcatcccc aatatatccc 2392441 cctcttgcga tttcacaagc ttcatcttca tctgctcgta tgtgaagcat gatttcggaa 2392501 gaggcaaaag ctgttctgaa ctgaccgaag ccaatatgcg gtcatcaaaa atggaagaga 2392561 tatcacacgc ccgtaatagc gcatgatgat gatgcaaaaa gcgtttttgt gcaagaataa 2392621 acccaagaca atctcctttc agagaaaaac aaatatcgga aattgtcccg agataactag 2392681 aagttcgttc tgagtatact gggaatcctt ctacttcatg gcatgttctc aaagtgtgat 2392741 caaccacctt ttgttgaaca ggcttaggtt ttgctttgcg ccttagactc atacgatgaa 2392801 atcaattcca ctgcaaatga aaaaaaactc ccgcttgcac gggagcattt tattgctgtt 2392861 cttctttcat aaaatcgaat ggtgtaatgc cttccatgcc aatgttggcg tcgtgtacgc 2392921 tgaacgggag ctctttttgc aaagcttcaa gctcggcatc catttcctca acctgtacgg 2392981 acagcctgtt tttcaaggag gtctgtctga cagttgcatc attatttttc acgccccact 2393041 ccagcgcctc ctcttccccg cataaaatga gaaatttctt cgctcttgta atcgcggtat 2393101 aaagaaggtt tcttctgagc attctataat agcctttcac aacaggcaaa accacaatcg 2393161 gaaattcact tccctgcgat ttatgaatag aacagcaata cgcatgggta aattgattaa 2393221 aatctttttt cgtaaatgtc atttcattgc cgtcaaaaga aacgacggcc atgtcttctt 2393281 tttctgtatt ttcctttgca taaaatatcg acgtgatttc gccaatatct ccgttgaaca 2393341 cattgttttc cggctgattg acaagctgca aaattttatc tccggttctg tagacaacat 2393401 ccccgaactt caattctctc cgtttttctt taggaggatt taaaatgtcc tgcagcatca 2393461 cattcaattc attaatgccg gcttttcctc tgtacatcgg agcgaggacc tgaatgtcct 2393521 ttgctgtata gccttttttc aatgcattgg cgacaacctt ctcaactact tctttgattt 2393581 gcgacccgcc gcagcgaata aaggaacggt cctttgtcgg ggcagtcaaa ttgttcggca 2393641 gcaatccatt tttcatctgg tgggcaagct cgacgattga tgacccttct gcctggcgat 2393701 agatgtctgt cagtctcaca gtcggaatca cctgggatgc cagcaggtct ctgagcactt 2393761 gtcccggacc gacggaaggc agctggtctt cgtctccgac aatgatgatt tgtatatgat 2393821 cagggatcgc cttgaacaaa tgattcgcca gccatatatc aagcatactg gcttcatcga 2393881 taattaacag cttcccttcg atcggctgat cctctgtatg agtaaagcct tcagcgccgt 2393941 tccagccaag cagcctgtgt atcgtaactg cagggagtcc cgttgattca ctcatccgtt 2394001 ttgctgctct ccctgtcgga gcggccaaaa caatcggaaa agcttcatcc tttttataag 2394061 ctgacgggtc tagtgacaca ccgtgaagct ctccgtagag ctcgacaatc cctctgatta 2394121 ccgtcgtttt tcctgttccc gggccgcctg ttaaaagaag catcggcgag gaaagggctt 2394181 tttgaatcgc ttccttctgg ctgggggcat actgaacgtc catccgttct tccagttctc 2394241 ccaacgcgag caaaaactct gattcgggaa actggttctc atattcggtt tggctagcga 2394301 tatgtttcac acgctttgca acgttttgtt ctgcgtaaaa cagcgaagga aaataacagc 2394361 ggccatcttc tatgacaatg tctttatttt ctccaagggc aataattgcg ttagcggcat 2394421 ccatttctgt aatgcgctgc ccttcccttg ctgactggtt taacagtgat tgagtgtcga 2394481 tgatcagctg ttccgtttct atgtacgtgt gcccctctga cagacaagtc gtttcaagcg 2394541 tgtacaaaat agcagctttt acccgctcag gatgattacc cgaaagaccc attctgctgc 2394601 ccagctcatc cgcttttcca aacccgatgc cttctacatc cttcacaagc tgataaggat 2394661 tttcctgaat cttttcaagc gtctcggatt cataggcttg atagattttc atagacagct 2394721 gcgggccaaa gccaaactga ttcaaggaaa tcatgatttg ctccagtccc tgatgccgct 2394781 gcaatgcgcc agccagcgtg tctgctttct tttttgagag tctgggaaca tcataaagca 2394841 ctgaagcatc agccaatatt ttattaatgg cgctgtcgcc cagctttttc acaatttctt 2394901 cagctgtttt tttgccgatc ccctcgaata aatcactcga taaatattga atgatgcctt 2394961 ccttagtcgt tggaatctcc tttttgaaat gctccgcctg aaattggagc ccgaattttg 2395021 gatgggttac gatctttccg taaaacgtgt aggtctcttc ttcttgaagc gcagggaagt 2395081 agcccgtcac ggatacggct ttatcttcaa tggcttcgga ggtctctgtg actttcactt 2395141 tcagaaccgt atataaattg gtgtcattat gatagatgac tgtgttgact gtccctttta 2395201 aatagggctc ttcctccagt ttaagctgat ccggatgctg ctgcacgagc tgtccctcct 2395261 cctgtgcctg ttatgatgga tcaatcagtt ttttagcatg aagcgcaagc atatgatctg 2395321 gctggatatc gattgccttg tccagcattt ccagcgcttt ttctcggttt tctttataag 2395381 cataagtgac accggcatta taaaatgcat ctgcatgccc cgggtcttgc tctgtcacag 2395441 ctgcgaattg gctgagcgct tcgtccagca tgccctcgtt ggctaagcac atcccgaatt 2395501 gaaaacgcgc ttccgtatcg ttttcattca gttcgactgc tctttgtaaa tatggcagtg 2395561 caagcttagg ctgttcgagc ttgacaagta ccgttccgag catgtaaaac aggtcgccgt 2395621 tttccatccc cgcacgtagc gctttttcaa acatgtcttt cgcttctttg tacatttctt 2395681 ttacaacata gacatttcct gctccataat aagcagtggc tgcgctactg tctaattcaa 2395741 gcgctttatc ataaaacgca agcgcacgtt ccagctcgtt tacggatgaa agaaggttgg 2395801 caaaattgat atacggaatc gcgtcttctt tattttcttc aatcgctttt gtaaatgcct 2395861 ctgccgcttt ctcgtaatcg ccttcctgca tcgcctctat accgagttga ttataatcca 2395921 ccgatcatct tcctttcatt aaaaaacccc aactcagtgt tgaggttttt catcttttat 2395981 acgtaccaca attttgttcc gtctttgtac acatcatcaa ttgtcccgcc gccaaggcat 2396041 tcttcgccgt catagaagac aacggcttgt cccggcgtta cagcgcggac ttgttcatca 2396101 aagatgactt ccgcttcacc ttcgccagtc atgcgcactg ttactttatg atcctcttgg 2396161 cggtaacgga atttagccgt gcaggaaatc tcttcgccct tcatgatatc cgaacgtacc 2396221 cagctgatat ttgttgctgt gattttgtcg gaatataaaa gcgggttatg gaacccttga 2396281 tctacgtaga ggatgttctt ttcaagatct ttgcctaccg caaaccacgg ctcgccgctt 2396341 ccgccgatgc caaggccgtg acgctgtccg atcgtatagt acatcaaccc gtcgtggcgg 2396401 ccttttactt cgccgtccat cgtcatcata tcgcccggct gtgcagggag atattggctg 2396461 agaaacgttt tgaagttgcg ttcgccgata aagcagatgc ctgtactgtc ttttttcgtc 2396521 gctgttgcaa gttctgcttc tttggcaatt tcacgcacac ggcttttttg aagttcgccg 2396581 atcgggaaca tgactttgct cagcgtatct tctgtcagct gattcaggaa gtacgtttga 2396641 tccttgtttt catcaatgcc gcgcagcatt ctgacttttc cgccgcttct gtctactctt 2396701 gcatagtggc cagtcgctaa atagtcggcg ccaagtgaca atgcatgctc caaaaaggcc 2396761 ttgaatttaa tttctttgtt gcacaataca tccgggtttg gtgttctgcc tgctttatat 2396821 tcatcaagga agtattgaaa taccttctca taatattgct tttcaaagtt tacggcataa 2396881 tacggaattc cgatttggtt gcagacgcgg atcacatctt cataatcctc tgtcgccgtg 2396941 caaaaaccgt tttcgtccgt atcatcccag tttttcataa agattccgat tacatcatag 2397001 ccctgttctt ttaacagcag ggccgccaca gatgagtcta ctccgccgga catgccgacg 2397061 acgactcttg tatcctccgg ccgtttttcc atttcattca ctccaattac tacgccgcct 2397121 tattatgtca gccgtttgac aacgtcggcc acatgtttgg cagcagtttt cacttgctca 2397181 gccgtattgc cgaggccgaa gctgattcga atagaggacg tcagccggtc actctcttcg 2397241 ccgaacatag cagtcagaac atgtgacggc aggactgaac cggccgtgca cgctgaaccg 2397301 ctggagacag cgacaccagc catatcaaga ttaaccagca gcgcttccac tgacacaccg 2397361 gggaaataaa gattcagaac atgcggcaga ctatgctctt tgtccccgtt gacctcgaat 2397421 gccacacctg catctctaag cgtgtcggca aagattgctt taaacgattg atacttctcg 2397481 tttttttcgt cacgttcttc acttgacagc ttgatcgctt ctttcagccc gacaatgcct 2397541 ggaacatttt ccgttccggc acggcgtttt ctttcttgct ctcctccgaa taaaaggggt 2397601 gaaagcttca catctttact agcatataaa aagcctgtcc cttttggccc gttgagcttg 2397661 tgcccggaaa cagacagaag gtcaatatgg ctgtttttca catcaattgg cagcaacccg 2397721 aatgcctgaa cagcatcggt atgaaaataa gctttgtgtt cctttaacag ctcaccgatt 2397781 tcttcgatcg gctgcactgt tccgacttca ttatttccat acatcactgt cacaaggatt 2397841 gtatcatcac gcagtgcttc tttcacctgt tttgcactga ctcttccatt ttggtcaacg 2397901 tccagatacg ttatgtcaaa tccgtctccc tcaagttttt cacatgtgtg aagcacggcg 2397961 tgatgctcaa tttttgttgt gatgatatgt ctgccaagat cttttcttgc aagtgcggtt 2398021 cccatgatcg ccaagttatc agcttccgtt cccccgcttg taaaaatgat ctcctgctct 2398081 gccgctccga tttctgctgc gatctgcgct cttgcttcat ccacccattt tcgagattct 2398141 ctgccaaatg aatgaatact ggagggatta ccgaaactgc cggagaagtg cggtatcatt 2398201 tgttccagca cgcgctcatc catcggagac gttgcggcat gatctaaata aatccgttcc 2398261 attatgttta cacctctgat ctaaatatag aacatataag cttcttgctc tccgtctgta 2398321 tagctggcaa gatcctctaa tgttgtactg tctaaaacct cttttacagc atcccggatg 2398381 cgaatccaga gctcacgctt ggcaggctcc tcatcttcca gcacttcaac agggctgatc 2398441 ggcccctcaa gcacacggat aatatctccc gcagtaatgg catccggctc actgcctaat 2398501 acatatccgc catatgcgcc tctgatgctt ttcactaaac cggcatttct gagcggcgat 2398561 accagctgct ccaaataatg ctcggacaaa ttattcgtct gtgcgatgct ttttaatgaa 2398621 gtcgggcctt caccgtgctt ttttgcaagc tcgatcataa tggtgagccc gtatcttccc 2398681 ttagttgata ttttcaacat gaacacctct gttatttcat gattttccac atttataatg 2398741 gtaatttcta tatgtttcgt ccgtttatta tcttatagac caactgttat tataacatac 2398801 cttcagcgaa ttttcattga ggcagaagga aaggggcctt tacccttttc taatgtacgg 2398861 ttttccgtta ccctgtaatt aagtaaggag agatgataga tgaagccatt ggcatatcgg 2398921 atgcgtccga caaaaataga ggatattatc ggccagcagc atctggtggc tgaagataaa 2398981 attattggca gaatggtcca ggcaaaacat ttgtcatcca tgattttgta cgggccgccc 2399041 ggaattggaa aaacatcaat cgcaacagca atcgccggtt caacaagtat tgcttttcga 2399101 aagctgaatg ctgtcattaa caataaaaaa gatatggaaa tcgtagctca ggaagccaag 2399161 atgtccggcc aagtgatttt gattctggat gaagtccaca ggctggataa aggaaaacag 2399221 gattttctat taccctattt agaaaacgga atgatcattt tgatcggagc aacgacggct 2399281 aacccgtatc atgccattaa tccggcgatc agaagccgga cccagatttt tgagcttgaa 2399341 ccgttaacac ctgaactgat taaacaggca ctggaacgtg cgctccatga tgagcatcgg 2399401 ggccttggca cctattctgt atccattgat gatcaggcga tggagcattt tgcccacgga 2399461 tgcggaggag atgtccgctc cgctttaaat gcgcttgagc ttgccgtgtt gtcaacgaag 2399521 gagtcagcag acggtgaaat tcacattaca ttagaaaccg cggaagaatg cttgcagaaa 2399581 aaaagctttt ctcacgataa agatggtgac gcgcattatg atgtactgtc cgcttttcaa 2399641 aaatcaatcc gcggctctga tgccaacgct gctcttcact atttggctag attaattgaa 2399701 gccggtgatc tggagagcat cgcaagacga ttgcttgtta tcgcctatga ggatatcggt 2399761 ttagcaagcc cgcaagccgg ccctagagtg ctgaacgcta ttcagaccgc tgagcgagtc 2399821 gggtttcctg aagcgcgaat cccgctggcc aacgcagtta ttgagctttg cctctcaccg 2399881 aaatcaaact ctgccattct ggcaatcgat gaggccctgg cagatatcag agccggaaaa 2399941 attggggatg tcccgaagca tttaaaagac gcgcattata aaggagctca ggaattagga 2400001 agaggaatcg actataaata cccgcacaat tacgacaacg gttgggtcga acaacaatac 2400061 ctccctgatc ctctgaaaaa taagcaatac tataagccga aacagactgg aaagttcgaa 2400121 tctgccttaa agcaggtgta cgataaatta atgaaaagaa aataaaacaa aaaaacagcc 2400181 ttgatcatca aggctgtttt tatgcattat ttatccttca cacgtttgat ttcaatgtct 2400241 ttcaaaagat ccatgacaac atgtccgccc ataatcaaac ctgcaactga cggcacaaaa 2400301 gcattagagg aaggcggcat ttttgcttta cgtattttcg cttcgtcatt ccccacttct 2400361 tttctgacat cttcccgaat aacaatcggg ctttcatcag agaaaatcac ttgaacgcct 2400421 tttttgatac cctccttgcg taatttcgta cgaacgacct tcgcaattgg atcagtgtgc 2400481 gtttttgaga tatcagcgat ttggaagcgt gtcggatccg ttttatttgc agcacccatg 2400541 ctggagatga gcggaatatc ccgttttaga cattctttca ttaaatgaat tttataacaa 2400601 atggtgtctg acgcatcaat gacatagtca agaccatagt caaaaaactg ctcatacgtt 2400661 tcctccgtat agaacatttt taacgcgatc acttcacact ccgggttaat gtctgcgatc 2400721 cgcgccttca ttaaatcaac tttcggctgt ccgacagttg aaagcagcgc gtgaagctga 2400781 cgatttacat ttgtaatgtc gacatcatct ttgtcgacaa gcagaatgcg gccgacgcct 2400841 gaccgcgcga gagcttccgc cgcgaacgac ccgactcccc cgactccaag cacagcaact 2400901 gtgctgtttt tcagcgtttc aaggccttct tttccgatag ctaattcatt gcgtgaaaac 2400961 tggtgtaaca agaacctcac tccacattcg tattctggtt tcatctataa aatggctgat 2401021 ccatgagcag ccgttttttc tgcgcacaaa aaataaagtc ccaatagtgc cgttgcagct 2401081 ttcctttgtt ttgaacccgc tctcagcagg tgggtgccct cttttaaatc ttgtaagtcc 2401141 tctttaccga atgaaaagag gcatgtacgc catttaaaaa tgcgggctcc caaatcaaaa 2401201 aaatgttcgg tcaaaactag gtgtacaact aacacatcag gactttattt aacttgtcaa 2401261 aatcatatca cagacgattt tgattttcaa gaatcgaact gcaaattcag ttcttaactt 2401321 ttttcttgat agaaagatga agctcgtcaa gctgggcgtc gcttacttcg cctggcgctt 2401381 ctgtcatcag gcagcttgca cttgccgttt tcgggaatgc aatcgtatct ctcaggttcg 2401441 tacgtccagc gagaagcata acgagacggt ctaagccgag tgcgattccg ccgtgcggag 2401501 gagcgccgta ttcaaatgct tccagcagga atccgaactg ttcagccgct tcttctggtg 2401561 agaagccgag aagcgcaaac attttttcct gaatatcctt ttcgaaaata cggattgaac 2401621 cgccgccaag ctcatagccg tttaagacga ggtcataagc ttgcgctttc atgtcttcag 2401681 gcgctgtttc aatcagctca aggtcttctc ggacaggcat tgtgaacgga tggtgcgctg 2401741 cgtaaaaacg gccttcttcc ggatcatgct ctaatagcgg ccagtcgatg acccataaga 2401801 aattgaacaa tttttcgtca atcagtccgc gttctttccc aagctttaag cgcagggcgc 2401861 cgagtgatgc ggccacaact tcgaattgat ccgctccgaa cagcagcaaa tcaccttcag 2401921 cagcatcaag tgcttcaatc agcttagact gcttttcttc atcaaagaat ttagcgatcg 2401981 ggcctttcac tccgtctgcc tcaaccttca cccaggcaag cccttttgcc ccgtagtttg 2402041 cagcaaaagc gccaagagcg tcgatgtctt ttctggagta atcgccggca ccgcctttta 2402101 cattgatggc tttgaccacg ccgccgtttg ctacagctga tgagaacact ttaaattccg 2402161 tatcctttac aatgtcagac acatccgtca aaagcatgtc aaaacgcgta tccggtttat 2402221 cagacccgta cttgttcatt gcttcgtcat acgtcattcg aggaagagga agctgaagtt 2402281 cctcaccttt tgtttcacgc ataacctttg ccatcatctc ctcagccaat gacataatgt 2402341 cttcctggct cataaaggac atttcaatat caatttgcgt aaactcaggc tgacggtccg 2402401 cacgcaagtc ttcatcgcgg aaacagcggg caatttgata atatcgttca atgcctgata 2402461 ccatcagaag ctgtttaaat agctgcggag actgcggcag cgcgtagaac tcaccttcgt 2402521 gcacacggct cggcaccaag tagtcacgtg cgccttcagg cgtgcttcct gttaaaatcg 2402581 gcgtttcaat atcaagaaac ccattttcat ctaaaaagct gcgaacagct ttcgtcacgt 2402641 tatggcgcag ctgcatcgtc tggaacatag ccggtctgcg caaatctaag taacggtgtt 2402701 ttaaacgaac gtcctctgac acttcttcag cttgatcaga aatcgcaaat ggaggtgtct 2402761 ttgcagcatt taatacgttc actccatcag catgtatttc gatcgcgcct gttttcaaat 2402821 tcggattaac tgttccctct tcacgcgcca ccacttttcc ttgaatatca agcacgtatt 2402881 catttctgat gccttccgca atagcaagcg cttcttttga cacatcaggg ttaaaaacga 2402941 cttgaacaat gcccgtacgg tcacgcaagt caataaaaat caatccgccg aggtctcgtc 2403001 ttttttggac ccagcctttc agcgttacag attcgccaat tgctttttca gttatatcac 2403061 cgcaataata tgttcttcca aacaatgcgt ttcactcctt atcccttttg gtttgccttc 2403121 atcacatgta taaattcatc aagtgccact tcaatctgtt cgcccgtctg tgcatccttt 2403181 acattgattt tgttttgggc aagctcatct tcacccaaaa tcgcaataaa tctggccttt 2403241 aagcgatcag ctgttttaaa ctggcctttc attttcttat tttcataatc gatttcactg 2403301 gaaatgcctg cttctctcag tttgtacacc aatgaaacag aataatcctt tgctttttcg 2403361 ccgagtgtga cgatatagca gtcgattccc ttatcaacag gcagctctct tttttcagca 2403421 tcaattgcgg caagcaagcg ttcgatgctc atcgcaaatc cgatgcccgg tgcttcaggt 2403481 ccgccgatct gttcgacaag cccgtcgtag cgtccgccgc cggcaagtgt cgtaatcgcg 2403541 ccaaagccct ccgcattgct cataatttca aatgcggtgt ggttgtaata atccagccct 2403601 ctcacaaggt tcggatcgat ttcatacgaa atgccaagat catttaagta ttgtttcact 2403661 ttttcaaaat aagcggctga ttcttcattt aaatatgtca aaatcgaagg tgccgatttc 2403721 atcagctcat gatcacggtc ttttttgcag tccaaaattc taagcgggtt cgtgtgcagc 2403781 cgggactggc agtctgaaca aaattcttcg atgcgaggct cgaagtgttt cacgagcgct 2403841 tctctgtagc ttttgcggct atcttgatcg ccgagactgt ttatgacaag cttaacgttt 2403901 tctaaacctg ctttttcata aatactcatc gcaagcgcca ttacttcagc gtcgattgca 2403961 gggtctttcg aaccaatcgc ttcaattcca aactgataaa actggcggta acggcccgtc 2404021 tgaggacgtt cataacggaa catcggcccg acataataaa gctttgtcgg ctgtacagga 2404081 tttgcgaaca gcttgttttc attaaaagcg cgaaccgcag cagctgttcc ctccggacga 2404141 agcgtcaggc ttctgccttt gcggtcctcg aaggtataca tttctttttg tacgatatcc 2404201 gttgattctc cgacgcctct ggcaaacagt tctgtatgct caaaaatcgg tgtgcggatt 2404261 tctttatatt gataagtgcg gcaagtgtct ctcataattt gttcaacaaa ctgccagcga 2404321 tctgattctc caggcagaat atcctgtgtt cctctcggaa tgttatatcc cataggtaga 2404381 cctccttatg tattccttat aaaatatcca atgatcgtta atgatgaaaa tgaaaaaaac 2404441 tcccgcccct actatacatg atagtaggga cgagagttat acccgtggtg ccaccctagt 2404501 tggaatacgt tcatattccc gctcgatcct ttaacgcagg ttcacgttca ctgcctaatg 2404561 gcgttattca cgcgttcagc aggaaacctc cggagtgttg tttcgagaaa gacgcaatgg 2404621 gatccgcttt cagcctgggg cgggttcctc tctaatcatg caatctgacc tactcttctc 2404681 cattattggt tcaaatcttt catcatttgc tatgtactca atttctatta taataatggg 2404741 attggggttc tctgtcaagc tttattccgg ttgtttttcc tcagcgctgc ttctttggac 2404801 ataagaccaa attcagatgc tgtttccgta agataaccag tcgtatcggg atctgcgtga 2404861 tcgctgtaat gcagattcgc ttcaccgtcg tgaaatgcac gtcccatttt tggatgatat 2404921 ttcatgattt gcacaccttt ttgattgtat ttacgcttag tataaacaaa tcattttatt 2404981 tttatttaaa aatcagaaag gactttacga tattaaacaa gaatgctttt ttaatgatca 2405041 tcagaaagga ggacacaatg aacaagaaat actttgtcct tattgtatgt attattttca 2405101 cctcagcgct attcccgacc ttttcatccg ttacagctgc tcaaggagaa gcggtcatcg 2405161 caacagatga aatgaacgtc agaagcggcc cagggcttag ctacggcatt acagcggaag 2405221 taaaaaaggg agaacgctat ccaattttaa aggaagatgg agactgggtg cagatacagc 2405281 ttggttctgg agaaaagggc tgggtagtct cctggcttat tacaaaggaa gaccaggcca 2405341 gcacaagctc ctcaggaagc agtgacactg tgacatcaac agaccccgat ctgcggatga 2405401 gaagcggccc gggcacttcc tacgaagtca tcggcaaatt cccgcaaggc agccaagcat 2405461 ctgtcattga taaagattcg ggctggatca agatatccta tcacagtgcc accggatggg 2405521 tatcatctga atatgtcaca tcaggaggca gcagttcagc gtctgatgag agtgaccaaa 2405581 ccgaggattc cggtgcgtca acgacgggca cagtcggtgt ttcttcgcta aatgtaagag 2405641 cctccgcctc acatgacgcg gcaattataa caaaacttga tcgcggaacg aaactgacgg 2405701 ttctcaacga gaaaaatggc tgggctcaca ttgaggtgaa cgggctaaaa ggctgggttg 2405761 caagccatta ccttttgact agttctgttc cagctgatga ttcagcaaat gccggcagtt 2405821 catcctccgc taaaaaagcc tatatcatgt acggaggaac gaatctaaga agtgatgcgt 2405881 caacatcagc ttcgatcgtt gagcgcgctg ccaaaggaga ttcatacacc attaccggtt 2405941 caaagggaag ctggtatgaa ataaagcttg ataacgggca gactgcttat gtagccaatt 2406001 gggtggtcca aacgtctaaa agcgcagaag aagcaggtga accgccagtc tctgattccc 2406061 cgtctggaaa cggctctcta aacaataaaa cgattattgt tgacccggga catggaggaa 2406121 aagacagcgg aacgatcggg tattcgggga aattcgagaa aaacctgacg atcaaaacgg 2406181 caaaactgct cgccagcaaa cttagatcgg ctggagcgga tgtatatgtg acacgccagg 2406241 atgatacctt tgtcagcctg cagtcacggg tctctacctc tcactaccgt aacgctgacg 2406301 cctttatcag cattcattat gacagctatg cggatacctc tacaagaggc agtacagcat 2406361 attactacag tcctgccaaa gatcaggaac tcgcatcaga tgtccactca gaagtggtga 2406421 agcgttcttc cattccagac cgcggcgtat tattcggaga ttattatgtg ctccgggaaa 2406481 acagacagcc cgctatgctg tacgagctgg gatatgtaag ccatccgcag gaagaagcca 2406541 ttgtacatag caattcatac caagaaaaag taacagatgg gatcgaaagc ggattagaga 2406601 aatacttcca ataaaaaaag ctgccttttg gcagcttttt ttattttgaa tccataatga 2406661 gcgtgaccgg tccggagttt gtaagctgaa catccatcat tgctccaaac gttccggtct 2406721 ccactttgat tcctttttca cgaagcaggt cattccattt ttcataaaga cctaaagctt 2406781 tatcaggttt ggccgcgttc atgtagttcg gccggcgccc ttttttcgta tctccataaa 2406841 gcgtaaactg tgagacggat aaaatctctc ctcctatatc tacaagagac agattcattt 2406901 tcccttcact gtcatcgaaa atacggagat tgacaacttt atcggctaaa taagctgcat 2406961 catcttctgt atcatcgtga gtgatgccga ccagcaccat aaggccttgt ccaatttggc 2407021 cgacgacctc ttcgtccact gtaacgcttg cttctgttac tcgctgaaca actaatctct 2407081 tttctaaccc ctttagttca tgacgcggcg cacagaatag atatctctaa tctgtttaat 2407141 acgctcgacg actttatgca agtgattgat attctggata aaaatcgcca tatggatggt 2407201 tgccacttta ttgcgatccg atttgccaga gacagatgaa atattggttt tcgtttcatt 2407261 cactgcctgg agtacctcgt tcagcaatcc gcggcggtca tacccaagaa tctctatctc 2407321 aacattgtat tccttgcgct tttgaacttg tgactcatgt tcccactcta ccgggatcag 2407381 ccgctcttgg gcttcattcg ttttgacatt cggacagtct tcgcgatgga ccgaaacccc 2407441 tctgcctttt gtgataaagc cgacaatatc atcacctggc acaggattgc agcattttga 2407501 taaacggaca aggaggttgt caatgccctt gacacgaacg ccagcttccc gttttcttcc 2407561 ttgcgggtat ggcttaggtt ccccagtgac ttcctgaacg atcttttcct gttcttcctg 2407621 gtcgcgctgc tttctctctt tttctgttag gcggttcgcc acctgcagag ctgtgatgcc 2407681 gttgtaaccg accgccgcgt acatatcctc ttcatttgag aaattaaatt tgtcagcaac 2407741 cttttgaata ttctccggcg ttaaaacatc cttcaattca aaatccaagt ttttaatttc 2407801 tttttcgacc agctcacggc ctttttcgac attttcttca cgccgctgtt tcttaaagaa 2407861 ttgacggatt ttatgcttcg cttgggatgt ttgggcaagc ttcacccaat cctggctcgg 2407921 accgtaggaa tgcttagagg tgagaatttc aacgatatca cctgtccgaa gcttatggtc 2407981 aagcgtaacc atttttccgt ttactttggc accgattgtt ttattgccga tttcagagtg 2408041 aatccggtaa gaaaagtcaa tcggaacaga accggacgga agctcgatta catctccttt 2408101 tggcgtaaag acatacacca tgtcagagaa caaatcaatt ttgagcgatt ccataaattc 2408161 ttctgcatct gtcgattcat tttgaaattc taaaatttca cggaaccaag aaagcttttt 2408221 ctcaaaggtt gcaccttcat tggctgcttt cccttcttta taagcccagt gagccgcaac 2408281 cccgtattcc gctatttcat gcatttcaaa ggtgcggatc tgcacttcaa gcggatcgcc 2408341 tttaggccca ataaccgttg tatgaagcga ttgatacata ttcggcttcg gcattgcgat 2408401 ataatctttg aatctgcctg gcatcggttt ccagcatgtg tgaatgatgc caagcaccgc 2408461 gtagcagtcc tttatgctat tcacaagaat acggacagcc aacaaatcgt aaatttcatt 2408521 gaattgctta ttttgcagca ccatttttcg ataaatgctg taaatatgtt tcgggcgtcc 2408581 cgagaagtca gccttgatat ttacttcttc gacacgtttc ttcacttcat tgacaacctc 2408641 atcgacataa agctctcgtt ctgcacgttt cttcttcatg aggttgacaa ttctgtaata 2408701 ttgctgaggg ttcaaataac ggagcgccgt atcttccaat tcccacttaa tttttgaaat 2408761 cccgagacga tgcgccaaag gagcaaaaat ttccagcgtt tcattggaga ttctccgctg 2408821 tttttcctga ggcagatgtt tcagtgtccg catattgtga agacgatccg ccagcttgat 2408881 caatatgacc ctgatatctt gagccatagc gacaaacatt ttgcgatgat tttccgcctg 2408941 ctgttcctct tgagatttat atttaatttt gccgagtttc gttacgccgt ctacaagcat 2409001 tgccacttct tcggaaaatg cttctttcag gtcatcgagc gtcacatctg tatcttccac 2409061 gacatcgtgc aaaaatccgc ccgcgattgt ggaagggtcc atttcaagat caacgagtat 2409121 ccccgcaacc tgaatcggat gaataatata tggctcgccc gatttgcggt attgctcgcg 2409181 atgagcatct tcagcgtaca gatatgcttt ttcgacaaat gcgatatgct catcagatag 2409241 atagctgcgt gctttatcta taacttgctc ggcagtcaat acttgttcgt tcgccatgga 2409301 atcacctttt ttaaaatgta aactgtattg tagtttatta tcaagaaaaa aacgaaagat 2409361 gtaaagagca gaagttcaaa tagccaaata ttatataaaa taaatgcaaa acaataggaa 2409421 aaaagcaccc tgacatggag tgctttttcg ttatgcggtt atccttagta tttcatcaat 2409481 gttaagatgt cgtaatcttc gagcttattt ctgccgtcaa ggtaagaaag ctcgattaag 2409541 aaagcgatac cagcaacaac gccgccaagt tcttcaacaa gtttgattgt cgcttcaatt 2409601 gtgccgcctg tcgcaagcag gtcatctgta ataagcacac gctgaccagg cttaatcgca 2409661 tctttgtgga tcgttaatac gtcttttccg tattccaagc cataatccac tttgattact 2409721 tcacgaggca acttgccttc tttgcggacc ggcgcaaaac ctacgccaag cgcgtaagca 2409781 acgggacagc cgataataaa gccgcgcgct tcagggccaa cgaccaaatc aatttgcttt 2409841 tctttcgcat attcaacaat ttgatctgtg gcatagcggt atacatcgcc tttatccatc 2409901 agtgtcgtaa tatctttaaa ttgcacgccc tctttcgggt aatccggtac aattgttacg 2409961 tattgtttta aatccatctg ttttatgtcc tcctcgtact ttcataagcc tctgaatctt 2410021 gtttcatcag cttattcagc cattccttca gctcttcagc agaagaataa ttcagctttt 2410081 gatccagttc catcagctgc tgtttcgcct gatatgtttg tgagtctgtt aagtcgcgtt 2410141 tctttgctcc gctcacaaca gacagcacac cattctctat tttaacaaaa ccgagatcaa 2410201 aaaacacctt tgtcatgaaa ttgattgttt caacggacca gcctttatgt tttgcaagct 2410261 ctgaaccgtg ttttttcacg tcaaaagcgc ctcttttcag caagaacgca taataccatt 2410321 taaagtggtc tcttgcggga aaagttgata aaaagtggtc ctcatgattg agaaaaataa 2410381 aatatatccg ctcgggcgcc tttccttcca gcaaacgtgc gagcatgtcc agcgaaggcg 2410441 gcggatccag taatacaata tatgcaccat cgaggtcaaa cgcctttgct tgatctttag 2410501 aactgatgac gtgcacttct cggcgaaggt cttcagtttg aagtaatgtt gttgagtctt 2410561 ctttgaaaga gacaatggcc cgtttagcag atggaagggc ggaaactgtg tcttcccacg 2410621 tccgttttcc ccttaaatca aacagctgcc attcagaaac agcggcatcc tttatcataa 2410681 gctgcggctt ttttcgattg ttccattcgt tgattgacat ctcaccgaca atggaaattc 2410741 ttgaacccgg tacgatgcct tcttgaagct cgcctttatt aaaaccgacg caatcaagct 2410801 gggacgactc gtttctgatc gtcattttga catgagtttt atttgcccct atcttgcgga 2410861 catcttccag tactgcattt tctacgagaa cgtgcggttt cgggttcagc atgccaaaag 2410921 gagacagcat gttcatttct gcgatgcttt caactgtaat gtcttcgacg ccgcagacaa 2410981 ggtcgacttc ctgtacggga ataaaatcct cttccgtaag cgtattgtcc gctatttcat 2411041 tcagcctgct tcgcaaatcc ggcacatctt cggctttcag cgtcatcccc gcagccattg 2411101 gatggccgcc gaaatgagga agaatatctc tgcattcaga aaggctctca aataaattaa 2411161 atcctctgat gcttcgggcc gaacctttag cgattccctt ttcttcatca ataccaagaa 2411221 caatggccgg tcggtagaaa cggtccacaa gctttgaagc cacaatcccg acgactcccg 2411281 ggttccatcc ggctttggcc acgacaattg cagtttgatc gagcccttgc tgttcaacca 2411341 tttcaatcgc ttcatccgtc attttgctga ccattttttg gcgctctttg ttcagctggt 2411401 caatttctgc ggcaagctct tccgcttcaa acgaatcctc tgacataagc aaatgaacag 2411461 cgggatccgc ctgttcgatt cttccgacgg cattcagcct tggtgcgagc tgaaatccga 2411521 ctgtttcttc gttcgcttct ccgatgtctc cgcctgacag cttaatcagc tcttttaagc 2411581 cgagccgatt tgtccgtcga agcctttcaa gtcctagtgt tgctattaat ctgttttcgt 2411641 catgcagcgg gactagatcg gcaatggtgc cgatagccgc caggtcaagc agttcatcag 2411701 gaagttcacc caataaagcg tgggcaagct taaacgcgac tccaaccccg gcaagctctt 2411761 taaacgggta agtgcagcca ggctgcttcg ggtggacgat cgcacggaca tccggaagct 2411821 ccggtcccgg ttcatgatga tcggtaatga tgacatccag tccgagttcc tttgccacct 2411881 tcgcttcatg cacagcggca attcctgtat caaccgtaat gatcaaagag aagccccgtt 2411941 ctttaatcga acgaaacgcc tgttcattag gtccatatcc ttctttaaaa cggtcaggta 2412001 tataaaaatc aacttgagcc gacagttttt gcagcgtgtg aagcatcact gacgtacttg 2412061 taaccccatc ggcgtcataa tcgccatata tcataatctt ttcttgttgt gaaatcgcct 2412121 gttttattcg atctgccgct tctttcatgc ctttcatttc aaaaggatca taaaaatcgg 2412181 catcctttgt atgtaaaaac agcctagcgc tttctgccgt atcaaagcct ctttttacaa 2412241 gcagggacgc aacaagaggt gttatatgca attgttctgt gagtgatttg accttatcct 2412301 gatctggtcg ctggatttcc catcgcattt ttgacgctaa cataaattca cccctcaacc 2412361 accctattat actagagcag gctgaggggt ttcaaataat attcgaaaac tagtcttttt 2412421 tctcaatcat ggctgatgca tcctgtgtgt cagtctgatc agcaagatga gtatcctctt 2412481 gtttatgtat tgctgttcta ttttctttcc gcaaggtttt tatttcccgc ttcaatttca 2412541 ttacctgaaa aatgccgaca gaaaatacga tcagtgctcc cattaaaact gagcccaaaa 2412601 taacaagaat gagcggccat tctgatcttc caaacaggta atcaacttct acggatcgaa 2412661 cattaatgac tgcgaaaata gcgacaatta aggtgaaaat aagtgcgaaa ataatggtcc 2412721 attgtttatt cattctcttt tcccccaaac ttcttattga ggtaactttc ccaatcaaga 2412781 ctggttttaa acatggctta acactaggtt aagctccctt tgctgttaat ttttcccgga 2412841 tcagcctctt cagtccggtt ccctcaccgg aaatcacaag tgtatcgcct tcgtcaatga 2412901 ctgtttcaga gctcggattc agttgtttat cctgattctt tttaacaatt gcaatgaccg 2412961 tcacatgata ttcctgaccc acattcaaat caccaatcgt ctgatgaatg gcaggcgctc 2413021 ccgcctctgc tttacaccac tctataatca aatcatcaag ggctgactcg acctgttcta 2413081 atgctttcgg tttatatgcc attccgccaa gaattgcaga catttgcctt gcttcagcgt 2413141 catcaaactg cacggaggca acacattcct catggtcgtt ttcgtcaaaa tagtaaagct 2413201 ctctccgtcc gtcatgatga atgataattg aaattttatc acggtttcta gtaatcattt 2413261 caactttttg tcctatgccc ggcagctctg attcgcgaac cctcatatat aaaccctcct 2413321 acatatctga aaaccagcca taaacacttt taacaccata tatatgttta aatgtaagcg 2413381 tatgtcatta tagcaaatgt ctattttaag ttcaatgaaa cttcaaaaaa caggctgccc 2413441 tgcagaggac agcctgatat tttttattgc gccgaatctt ttttcagttc tcttcctttc 2413501 catgcaagcc aaatttgtgc ggcaatgtat agagaagaat aaacgcctgt taacagcccg 2413561 accaataaag caattgagaa gttagtaata gaagatgctc caaagatcag caatgtcaca 2413621 acaacaatca caacggttaa tacagtgtta attgaacgtg taaaggtttg ctgcaggctc 2413681 aggtttacaa tatggttcag atcggcaaag gttttcggct tacgcttttt catatgctcg 2413741 cggaccctgt caaatgtaac gattgtatcg ttaatggaat acccgattat cgtcaagatg 2413801 gccgcgatga atgtaacatc tacctcaagc cttgtaatac tgaagaacgt gacgataaag 2413861 aatgcgtcat atagcaatga ggcgatggca gcaatcgcca ttttgtattc gaatcggatt 2413921 gaaacgtaaa taatgatgcc aatagaagct atagcaactg cgtacagcgc atttctcgcc 2413981 agctccttac cgactgtcgg tgaaactgtg ctgacatttg gatcagatcc gtatttgtct 2414041 ttaaaatacg tttttacttt tgcaatggtt tctttatctg gcaccccgac aaaacgggca 2414101 acaccgatat tgctcttttc gcctgacaga actacagtat cagggtccat acccagagat 2414161 tcaaaatcct tctcaacttg ctctgtcgtc agcttatggt cgctttgcac ttcaatccgt 2414221 gcaccgcttg caaagtcaat gccaagattc agcctgaaca caagcaggat aataatcccg 2414281 gcaaccgtga ccgcactgga gaaaataaag aagtatttgc gtttgctcgt gaaatcccat 2414341 ttttggaatg gcgtatgcgg ctctgtattt tcatccgtat cctgaatatc catgatatgt 2414401 ttcttattga caccaaacca gccttttttc cgatcaagcc atctgctttc cacaaggaga 2414461 gcgaggagaa atctcgataa gaaaacggca gtgataaagc ttgtcaaaat cgataggatc 2414521 agcattgtcg caaacccttt aacagagctt gtcccaaaga taaagagcac aaccgctgca 2414581 ataatggttg taatattcgc gtcaaaaatc gtcgcaaatg accgtctgtt tcctgaacgg 2414641 aaggcagagc ggactgactt tcctagcttg agctcttctt taatccgctc ataggtaata 2414701 atgttggcgt caacagccat cccgacacct aaaatgagag cggcaattcc cggaagcgtg 2414761 agtacggcat tcatccagtc aaagatctgg agtgtaatgt agatataaac agacagcgta 2414821 atcaccgcga ttaatcccgg cagacggtaa tagaaaagca taaataagaa aataattgcg 2414881 ataccgacaa taccggcaaa caccgtatca tggagagcct gctggccgaa ttgcgcgcct 2414941 actgatgtcg aatacttttc agtcagtttc acaggaagtg cgcctgcgtt taaaatgctg 2415001 gctaaatctt tcgcttcttg agctgtgaaa tgaccttcaa tttttacatc agttgtattt 2415061 agttcctgac ttacatttgg agcggataca aatttaggat gctctttttg aacttctttc 2415121 ttaaaggaat cacctttatc ataatccaac caaatgacaa gctggttgtt tggcgccatt 2415181 ttcatgacct tcttggtcac ttcaccaaat ttatcagcgt ctttcagctt aatcgtgaca 2415241 attggctcat ttgttgtgct atcataagtt tgtttagcgc cgttttcgac tagatcagca 2415301 ccgtttaaca gttccttatc atttgcatct ctgaaagaaa gctgcgcttc agtcgccaaa 2415361 atttcacgcg ctctgttttg gtttgtcacg ccagcgagct gaacgcgaat ccggttattc 2415421 ccttcaattt ggatgttcgg ttcgctgaca ccgagaacat tggcccggcg gttcagtgcc 2415481 tctactgtgc tgaccagaac gtcttttgtg attttgtcac ctttttttac aggctgtaca 2415541 tcatacagca cctcaaatcc gccttgcaaa tccaatccta acgtaatatt gttagcggca 2415601 ggcttcgtaa agtagcccaa gcccgtgccg atcaatagaa cgaaaaggaa aaacgcaatc 2415661 aagcgtcctt ttttcattat gtatatcctc ccttaaacct gtgcgaatca acctgctatc 2415721 tcagcagttc ttccaatgct tcctggccct cttcactgcc cagccaatta gacgttttaa 2415781 atgactcaac ggttgcatag ttcataaatt cgccaatttt cactgataaa atatcactcg 2415841 ccagttcata aatgctcagt tccgttttct ttttccactt cttatctgtt aagtatgacc 2415901 acaaactttc gagttcaaca tcatcatacc cgagaatctt aaactcttcc agtttgctgt 2415961 aaagaaacgg cctgacgtgg tctttatata gatcggctgg atgcttctcc acgaattcca 2416021 cgctcctttt ttattgtttt tcaagaagac ttgtcatgct tggacgacat atacgcatat 2416081 ctttattgta tatgattcca ggtagtttga gaaggcaggg ggtaaaaatg gcgaaacaga 2416141 cgtttttaaa gggcactctt atccttatcg cagcaggaat ggttacaaga atgctcgggt 2416201 ttgtcaaccg ggtggttatc gcccgtttta tcggtgaaga aggagtcggg ctttacatga 2416261 tggcagcgcc tactttcttc ttggccacta cattaactca attcggtctg ccggtcgcga 2416321 tcagcaagct agtcgctgaa gccagtgcgc gcggagatca tcaaaaaacg aaaaatattt 2416381 tagtcatgtc tctgaccatt acgggagtgc tcagcctcat ctttacaccg ctgtttctgt 2416441 ttttcgcccc tgttatggct gaaacgatgc tgacagataa gcgaacactg tatccgctct 2416501 tggccattac gcctgttgtg ccgattattg ctatatcgag tgtgctgagg ggatactttc 2416561 aaggaaaaca gaatatgaac ccgcttgcta tgtcacaagt ccttgaacag gttgtccgca 2416621 tttcactcgt ggctgtctgc acaacgattt ttctccctta cggaattgaa tatgctgcag 2416681 cgggggcaat gctatcctca gtggcagggg agctggcatc acttctttat ttattcgttt 2416741 gctttaagta taaaaagaca attaaaatca gaaagcattt tttacagtca attaaaaacg 2416801 gaaaacaaac ctttacccaa ttaatgagcg tgtcccttcc aacaaccggg agccgcttta 2416861 tcggaaacct ctcttggttt ttcgagccaa tcgtcgtcgc tcaaagcctt gccatcgccg 2416921 gtgtggcaac agttgccgca acaaagcaat acggggaact aaccggcttt gccatgacgc 2416981 tgctgactct gcccagcttt attacatatt ctttgtcgac cgcgcttgtt cctgcgatca 2417041 gtgaaggaat ggagcagaaa aaattgcagg tggtggaata ccgcttagaa caggcgatgc 2417101 gtctctgtct gctcagcgga ggcatttcag ttgttatttt atttgtattt gcggatgagc 2417161 tgatgagagt gatgtacggt tcctcaggcg cagctgtatt tataaaagtg atggccccgt 2417221 tttttctgct ttattatttc caaggcccgc ttcaagctgt gctgcaggcg cttaatttgg 2417281 caggagctgc gatgatgaac agcttaatcg gagcgcttgt caaaacaggc cttatttttg 2417341 tccttgccac aaggccttct cttggcatta tgggcgcggc attagccatt gtgacaggca 2417401 tggtgctcgt cacgctattg cacgcagcaa ccgtaagcaa agtgctgccg atcagcatca 2417461 aaatcaagga gtacgcgctc agcttcgctg ttattgtaat ttgcggattc atcagctccg 2417521 ccatcaaaca atatataagc tttggagcat ctgaggctgt caatctagcc ggatggattg 2417581 cggcgagcgc cgccatttat atgatcctcc tgctcgtttt ccgtttaatt aaaaaagatg 2417641 agcttcgccg cattcccatt atcggacggt tgatcatccg ataatggtca cgtgcggtgc 2417701 ccatcttttt catcaatata tatttctccg tctgtaaacg agcaaaatga aatatctgaa 2417761 gggtttgtgt atccgtgttt ttgcaaactt tcaagcagcc attttctatc tttactgatt 2417821 ctggacaggt tttctgtttg aatgaagccg tctataatga gcggcatttc gagctgccga 2417881 tgctctccgc tgttttcttt cttaacaata gtcagtttgc ccgacggctc taaaatagca 2417941 aatgatacgt cagctactct gtcgatgcta ttttctctga gctgaaccat taaatcatca 2418001 aaattataac gctgtgattt catggcttct tcgtcaattt ttccatattt gataattatg 2418061 gtcggcttac cgtcaagaag ctggcggact tttcggtttt ttaaagaaaa gtatgccaaa 2418121 gtcacttgaa tgatcattaa tacaagcatt ggcaaaatgg tatgaaatag atgatcgtct 2418181 acgttttcta tggctaaaac ggcaatttca gccatcatga taaagacaac gagatctaaa 2418241 atactaagct ctccgatctc ccgtttgccc atgaaacgaa aaatgaccaa tatcacaaaa 2418301 tacaatacga ctgtgcgaaa cgcaatagtg agaagctctt ccattatgca cctccaactc 2418361 attataggtt gcaacaaaat gatcaattta tgtaagaaaa accgattgca tttcacaaag 2418421 cttttacgtc taattcatgg gataagggaa tacattttta caaagacgag ccatcagcat 2418481 gtctgacggt tttgaacaaa aagaacagaa gccttttaat acaggcagag aggagacaat 2418541 catggaggaa acgaaacaag ttggaaaagg cattctttac ggcttaatcg ccatattttc 2418601 agccatgctc ctgacaagtt tagcggtttc acttttattg accgcaacct cgctggaaga 2418661 atcatcattt aactggctga tcaccgctat ctcatttctc tctttattta tcggcgggtt 2418721 catttcaggc gggaaaggca aggaaagagg ctggatgatt ggcgcattga ccgccttaag 2418781 tttttctctg attatcttat tgtttcagta tttaggattc ggaaagacat ttacagcaga 2418841 acagctgatc ttccatctgg gatttttagg ggtgtgcatg ctgggcggga ttttcggcgt 2418901 gaacatgagg ggaaacaggt cttccacata aaaaagagcg ggctcacttg cccgctcttt 2418961 tttgtttgct atgtatagct cctgctgtta ttcagcagca gaaacttctc tgatcgcgcg 2419021 gcggtcgaac gtaagacgtg tgttatcacc agtcttaatt acgactttgc tttcgtcgat 2419081 agagtcaaca gtaccgtgca atcccccgat tgtcactact gaatcgcctt ttttcagttc 2419141 ctcttgcatt tggcgtacag ccttttgctg cttttgctga ggacgaatca gcaagaagta 2419201 aaggaccgca aacattaaaa taataggaac caatgtacct aaagtgccag tcatcatttt 2419261 cacccctttc tgtaagcctg ttatgtttat ttagaagctt ttcgcatttg gcttgttata 2419321 gccgtaacgc tcaaagaact cttctctgaa atcacccaga cgatcctcgc gaatagcctg 2419381 tcttacctgc tccattaagt gtaacagaaa atgaaggtta tggtaagttg ttaatcgaag 2419441 gccgaatgtt tcattgcagc gaatcaagtg cctaatgtac gcgcgagtgt agtttttaca 2419501 tgtatagcaa tcacactctt catcaatcgg acggaagtct ctttcaaatt tcgcattttt 2419561 catattgagt cgtccttcag cagtaaacac tgtgccgttt cttgcaatcc gtgtaggcag 2419621 cacacagtca aacatatcga ccccgcggat cgctccgtcg atcagtgcgt ccggagaacc 2419681 tactcccatc agatatctcg gtttatcctt cggcaagagc ggtgttgtga attcgagtac 2419741 acggttcatg acatccttcg gttcacctac agacaatccg cctatagcat atcccggaaa 2419801 atcaagcgaa atcaagtcct tcgcactttg tgtccgcaga tcttcatatt ctccgccttg 2419861 tacaatacca aacagccctt gttcatcctg acgattgtgg gcattcaggc agcgttccgc 2419921 ccagcggctt gtccgttcaa ctgacctctt catgtagtcg tactccgccg ggtatggcgg 2419981 gcattcgtca aacgccatca taatatcaga gccgagtgcg ttttggatct ccatcgcttt 2420041 ttccggagat aaaaacagct tgtctccatt tagatgattg cggaaatgga caccctcttc 2420101 ctctatatta cgaaacttgc ttaaagaaaa gacctgaaaa ccgcctgaat ctgttaaaat 2420161 tgcgcggtcc cagttcataa atttatggag cccgcccgct tctttgacaa tgtcttggcc 2420221 cggacgaagc catagatgat aagtgttgct caaaatgatg cctgcatcca ttgctttcag 2420281 ctcttcaggc gacattgttt tgactgtcgc cagtgtgccg accggcataa aaaccggcgt 2420341 ttcgaaggag ccgtgaggcg tatgcacttt gcccagccgc gctcctgttt gtttgcattc 2420401 ttttataaat tcatagcgta ttggttgttc agccactttt gatgaggcct cctgttctca 2420461 aattatataa tcagcatcgc gtctccgaag ctgaagaaac ggtattcctc ttccactgca 2420521 tggttatagg cacgcagaat gttttctctt ccagcaagcg cgctgaccag cataatcaat 2420581 gacgatttcg gcaaatggaa gtttgtaatc attccgtcaa tggctttaaa ttcatagccc 2420641 ggataaataa aaatagatgt ccagccgctt gatgctttaa attgcccgtc atgttctccg 2420701 gcaatcgtct caagcgtgcg tgtcgaggtc gtgccgacag aaatgatccg accgccattt 2420761 tctcttactt tgtttaaggc tgcagccgtt tcttctgaca tttgataaaa ctctgcatgc 2420821 atattatgct cttccacttc atcggcactc acagggcgaa acgttccaag gcctacgtgc 2420881 agtgtgatga actcaatttg cacgcctttg tctttcagct gctgtaagat ttcttccgtg 2420941 aagtgaaggc cagctgtagg cgcagcagca gagccaattt cttttgaata cactgtctgg 2421001 tagcgctctt tgtcatcaag ctgttctttg atatatggag ggagcggcat ctctccaagg 2421061 gattcaagca cctcgtagaa aataccgtca tattgaaatt ccatctttct gccgccgtgc 2421121 tcaagctctt ccgtgcagat tgccttcaat cttccgtctc caaatgtgac aacagttcct 2421181 tttttcaccc gtttcgccgg tttggcaagt gtttcccatt tatcaccggt ttcctgtttc 2421241 aacaaaagaa gttccacttt cgcgccggta tcctcttttg tgccgaataa ccgcgcaggc 2421301 agtacccggg tattgttcag gactagacaa tcgccttcgt taaagaagct gataatgtgt 2421361 ttaaacgagc tgtcagtaag ctctcctgta tgtttatcga gcaccatcag ccttgaagca 2421421 tcacgctgct ccaacggtac ttgtgcaatt aaacgttctg gtagttcaaa atcaaataaa 2421481 tcgactttca tgatgatttc acctttattc tagtcttttg ttatttcatt ctgccaaaaa 2421541 gattaagcaa aattgataat accacactta taataataca agtgacaacc gggaagaaaa 2421601 acgtaacatt tccttttttt acaaaaatat ctcccggcat cttgccgaca aaatgcaaaa 2421661 ctgctccgat aataagcaaa acagcaccaa gaatcataat gatcttagga aattcagtca 2421721 tatcggggag cctccatttg gaaatgatga taaacggccg gtgtcacgat ccttccacgc 2421781 ggcgttcttt gtataaatcc aatttgcagc agatatggtt catatacgtc ttcaatcgta 2421841 tgcgattcct cgccgatggt agctgaaatc gtatcaaggc ctactgggcc gccgttgaat 2421901 ttttcgatca tgcccatcag cagcttatga tcaatatgat ccaaaccgag gcggtcaacc 2421961 tgaagccgct ccagcgcatt ctgagaaatg tcttccgtaa tcctgctgtc acccagcact 2422021 tgggcgaaat cgcgcaccct tctcagcagg cggttcgcca cgcggggcgt ccctctcgat 2422081 cttcttgcaa tttcaagagc cgacggttta tcaatctcaa cctcgaatac atcagcggtt 2422141 cttgtgacaa tatccgccag ttcttcttgt gtatagtact caaggcgaga cattacgccg 2422201 aatctgtctc ttaaaggagc cgtcaaaagc cccaccctcg tcgtggctcc caccagcgta 2422261 aaaggcggaa ggtcgaggcg aaccgagcgg gcagatgggc ctttgccaat cacaatgtcc 2422321 aggcaaaagt cttccattgc aggataaagc acctcttcga tcgatctgtg cagcctatgt 2422381 atttcatcaa taaataatac atctcccggt tccagcgccg ttaatatagc agccaaatca 2422441 ccaggccttt caatcgcagg ccctgatgtc gtccgcaatt ccactcccat ttcattagca 2422501 acaatcgaag caagcgttgt ttttccgagt ccgggcggcc cgtacagaag aacatgatcc 2422561 agcgtctcct gtctcatttt cgccgcatct ataaacacgc gcaaattttc ttttacctta 2422621 tgctgcccga tatactgtgc cagattttgc ggcctcaggc tttgctctat cactgattca 2422681 tggttgtctg cttcacttga gacgagccgt tcatccatga acatcacctt actttaatag 2422741 tttttgtaat gcttttttca catattggtc tgttgtcagc ccaatttctt ctttaaggtg 2422801 aggaagcacc tttttgattt ctttttcagc atatccgaga accctgaggg cttcaagtgc 2422861 ttcttcaaga gccgtttccg ctgtttgctt ttcaagcctt tcttcatgat taaacagatt 2422921 ttcaatcatt tcaggcacaa catctgccag ctttcctttt aaatctagaa taatctggcg 2422981 tgcggttttc tttcctactc caggaaactt gaccaaaaaa gcttcatctt cattttcaat 2423041 tgcttggatg accgctccgg gatcacccga gcccaagatg gcaagtgctc ctttcgggcc 2423101 aattccggtc acgtttaaca gctttgtaaa gagcgccttc tcctctcttg ttgaaaaacc 2423161 ataaagcgaa aaagcatcct ctctgatatg atggtatgta aaaatcgttt cttggcttct 2423221 ctccttatat ataaacggat tcggcgtgaa aatctgatag ccgatgccgc cgttctctat 2423281 gacaatatat tggggagata cataatcaat cgtcccttta acaaattcaa tcacgcaaat 2423341 tcacctcttt gactgttctt cattgtacca taaaaacagc caaagtctta tagaaaagtt 2423401 aacatatgtt cgcttctctc tcattctttc acgaaaaaaa agacatgaat acatgtcttc 2423461 aatcagcgga cgctacccgc tgtatgtctt catatgttcg atgacatcct caaactccgc 2423521 ttttgtccga aatggaatgc ctttcagcag atttttttgc atatggcttt ccagcctttc 2423581 taaatcaatt tgaaaaaaag actgaattgg ttcggaagct ggctcaggcc gcccatgaaa 2423641 agtggaaatc actccattat ccgatacacc gatatacccg ttgaccttgc tgagcggaga 2423701 aatatcgtcc atttgcttcc ggaagagcac atatcccttt ttttgttcca ctagcgtcca 2423761 tccggcataa gctgcccaaa aatcatccat agaaaacact ttttcatgct tatgctcaat 2423821 gctgacatcg ccgtccaaat acaccttttc aagctgcaca tgcacctgca gcggctcata 2423881 gtgctccact tccgcgccaa gtgcgcggga aggagctcct attaaaaata ctgccgctga 2423941 gcaaagaatg cccagcaaaa gatacgccgt gctgaatcgt ttcaccctct acacctcttt 2424001 gcacacgttt atgattagtt tgaccaaaga ggctactgct taaccgtttt atcaaaattt 2424061 gtctgcacat tttccctgac aaaccgttcc tccgtataca catctgtgct ttgctcagaa 2424121 attgtcaaga atcgcgtcag aaaggcactg aaaaaataca atgccgcaaa gatccaaatc 2424181 acgccacctg caccgagcgg cccaatgaaa agactcacga tgcccggcgc gataaacgca 2424241 cataaaccag atcccaaatt caacactgac atggcagcac ctttattatc aggtgcaagc 2424301 gtcggcaaaa gcgcgcttaa tgggacgtac cctgctaaag ccgcgccgta gcagcaggcg 2424361 ataatcatga gcacccaata ctgatgcccg atcagctgag gcgtgtaata cagcgccagc 2424421 gtaaaaatac cgcatccgac accgccaaac cacatgaccg tattgcgcca gcctagttta 2424481 tctccgactg caccgaaaat gatattaaac acaatattca caaaaaacag cgtcccccat 2424541 atttgcagcc attccgaaac cgaatacccg tatcgtgcta aataagtagg aagaaagatg 2424601 gcaaatccaa attgtcctat cgcattaatc gtcttgacca ctccgccgat gcctacctta 2424661 gggttttcaa acataatcgt aaatgccttc gacagttctt tccatttcgg ctgatcttgt 2424721 ttttgtatcg gagtaaattt atctttgtta aaaaataagg caagaattcc gcctgccgcc 2424781 acaaacagta aagcgctcca aagcgtattg atttctccaa aggccggaac tgcatagctg 2424841 gaatagaacg gaccgagcac gttaaggccg cacgtaaaca taaaccaaaa ccagccgacg 2424901 gcttttccaa gaatattttg agaggtgctg tatgacaccc atacgagaaa agagtatgca 2424961 aacagcggat atcccaagcc tctaagagca tagctgccca agagagccgg ataatacata 2425021 tgaggaatcg cccagccgat aaaagcggcc gaaccgagga taaatgcaag caatccgaca 2425081 gtcatcgttt ttctcggccc ccaagtttgg acaaacgttc ctgaaagcca agctgagatg 2425141 gtgacagcaa tgccgtacat ggtaaataac gatgcggatt gctgcatact gagaccatga 2425201 tcaacgagaa aaggagacag ccagccttgt tcgaggccgt ctccaaccat aaagatgaca 2425261 acgccaatat aaccccaaac catgtgagaa ggaattccga ttttgttcaa aacatttcct 2425321 ttagcatgta ctgtattcat tttctccacc gcctacttaa agtatcaatg gagtatatac 2425381 ccaagcttgc tgaattgtaa tcctgttaga ttaaaaagcg attttttcag tgtgctcaat 2425441 gctaacaggc atgccaaaag caagcgattg ctgtgctgct ctggcgatcc tcccggcctg 2425501 taaaccgtca ttgccggtgc agggagtctc ctggtttgtg ccgatcgctt ctgcaaaacg 2425561 gagaatctcc tcctcatatg aatccttata gcgttcaagg aaaaagaaat gcggtttatc 2425621 cttcatcaca aaatcagctg ttgacacctc aaccgttgtc ggcctgctat tgtcagccgc 2425681 tgcagagcct ttcgtcccga aaacctcaac ccgctggtca tatccgtaca cagcttggcg 2425741 gctgttatca atcacagcca tggcaccgtt ttcaaaagtc agtgtaataa cagctgtatc 2425801 aatatcaccc agctccgcaa aagaaggatt caccaaagcc gcccctttgg catacacttc 2425861 cgtcacttcg cttcccataa tatatctggc catatcaaaa tcatggatcg acatatccat 2425921 aaacaatccg cctgacgtac ggacataatc tatattcggg ggttctgggt cccgggacgt 2425981 gatttttaat aaatgaggtg taccgatttc accattttca acaatcgttt tgattttctt 2426041 aaaatgagga tcaaagcggc ggttaaatcc gacttgaagt gttaccccgt gtttccggac 2426101 agccgcaagc gcttcactcg tttcgtccag agagaaacta acgggcttct cacaaaatat 2426161 atgctttttc gcctcggctg cttctttgat catctgtgca tgtacggctg taggagagca 2426221 aataaaaata gcatcaatat caggatcatg taataaatca cgataatcag aggttatgta 2426281 ttcaatctga tgactgtcgg cccagctttt tatacggctc gcctgaatgt cagagattgc 2426341 ttttattttc atgtgaggaa tccggcttat attttgaaca tgaagtttgc cgatgcggcc 2426401 tgcaccgata atccctgtca caatctgttt tgtcatggct tcttccccct tgatcattca 2426461 cgaaagcgct ttatttaaaa ttaatactat cccatttgta agcgcttttc aagaatggaa 2426521 attaaacgtt ctatgtctct tttatcacaa ttcatgctta taagtagcct tcttcttcaa 2426581 gaccagatac actagaatta ggctcttttt cctgaacagt ttatgatttt cctataaaca 2426641 gctgcataaa atagagcaaa gaaggtgaat gaaatgctga caaaagcaga ggcactggcc 2426701 cataccgtca tataccgcaa gaacagcaga tttgataaag tcaaagagaa atccgaggaa 2426761 ttaacactaa tcggcaaggg aagaagcgcc tatgtgtttg ccttaacaga aggcggtcga 2426821 aaaatggcgc tgaaagtatt ttttccggaa tatcaagcga cagcagtcaa agaagcagcg 2426881 atctatgaaa aattagccgg gtccgcattc tatcctgaca tttacgaaac tggcgattca 2426941 tttattctca tggaatatat taaaggtgaa accttttata actgtctgaa gaaaggcatt 2427001 gcaatcagtg atgacatgat tcagcaggtt gaagaagcgc tttctgacgc ccgggcagcc 2427061 ggactgaacc cgtcagatat tcatttgcgg aatctgatat tgacagaaac cggggcggtg 2427121 cgggtgattg atgttgcgag atttgagcag acaaaaacat gcacgcagtg ggacgactta 2427181 aaatccgcat atcatgcact ctacaaaaaa ccgatattcc ccaaaaagat tccgggtttt 2427241 tggctggaga tcatcgcatt tttatataag aaagattggt ttcaaaagca tttcgcacag 2427301 cggaaaagaa aatattctta aatcaaaaag gcagccgcac aagcggctgc ctttatcatg 2427361 tattttttac tttctgacgg cagaaatcag tttcatttgt tcaggcgaca gcttaattcg 2427421 atagcctctc acagttaagt agaccgcttc tgggtccttc tcgccggaat gacaatacgt 2427481 tttttccatt tctgtctccc ctcacccttt attggcttta tttcatctta tcattgcttt 2427541 attgaggtaa ttttaaagaa atgtaaagat tatatgaatc cgatatatag taaaatgaga 2427601 gaaaaaaagg gagagagtca cattaagacc gaaaacacct tgagcttaga tgcagccaga 2427661 ggtgaacttg taaatgaaaa aacacttgtc aagagaacaa tctactggaa ttacccggac 2427721 agccgcccag cagtgacgtg gatcaatcac aatacagtga aaatcggcaa tcagacttta 2427781 catcttgata ctgatgaaac gtatgattgg cgaaaagatg atcattggat ccgtgaagaa 2427841 ccgccgcagg cgtcagtgag gtgatgaaac atgaataaga tgaacggaac aaatgatgaa 2427901 aagcatttca atcattttgt gattgcttta tcctttatat acggtttgac tgaactaggc 2427961 tatttgttgc tgaaggattt tataacaatt gccataagtt tgcctctgta gaaaaacgca 2428021 gcgtagtcga tacgccgcgt tttttctttt tcccttcctc ttcttattga taattacagg 2428081 tcatataatg tgacaaatcg attgtagaaa tagttcgatt agaccaaaat cctttttata 2428141 catgtattcg aatttgaagt gagggggaag cttgatggca gattttgttg ctagtttgaa 2428201 tgcggtctta tggagtacgc ccgtcattta tattttattg ggaattggat tcgccttttc 2428261 aattatgacc cgttttttac aagtccgaca tttaaaagaa atgattgttc agatgttcaa 2428321 aggcaagagc tctgaagccg gcgtttcatc tttccaagcg ttatcgattg cgctgtccgg 2428381 ccgtgtgggc acaggaaaca tcgcgggagt ggcgacagca attgcattcg gcggacccgg 2428441 tgcagtgttc tggatgtggg cgattgcctt tatcggggcg gcgagtgcct ttgtagaatc 2428501 aacgcttgct caaatttaca aagtgaaaca agacggtcaa tatcggggcg gccctgctta 2428561 ttatatagaa aaaggcttag gcattaagtg gtttgccgtc ttatttgccg ctgctgccct 2428621 tattgcaatg gcctttctaa tgccgggcgt acagtccaac tccattgcgg ctgggatcca 2428681 aaatgcattc ggcatctctc ctttcgtcac agggtgcggt ctggttttat tattagggtt 2428741 cattattttt ggcggcgtca aacgaattgc caatgcggcg caaatgattg ttccatttat 2428801 ggccattgga tatatcctgc tgtctttgat tattattgtc atgaatgtgt ctgaattgcc 2428861 tgctgtgatc tcattaatat tcaaaagcgc cttcgcattg gattccgctt ttggcggctt 2428921 gatcggtatg gcgatttcct ggggcgttaa acgtggcatt tactcaaacg aagccggcca 2428981 gggaacaggc ccgcatccgg cagctgctgc agaggtttct catccggtca agcagggact 2429041 ggttcaggca ttttctgttt atattgacac cttgtttgta tgttccgcta cagctttcat 2429101 gatcttgttt accggcatgt acaataccca ggctgcagat ggttccttta tcgttcacca 2429161 gcttaaaggc gtagaagcag gacctggttt cacacaagcg gcaattgaca gtgttcttcc 2429221 cggattcggt gcaggctttg ttgccatcgc tttattcttc ttcgctttta caacaattat 2429281 ggcgtattac tacatcgcag aaacaaatat cgcctattta gcacgaggca gagaaagcaa 2429341 atgggcgatg cttggcttaa aactgattat tttagccgcc acgttctatg gtactgtgaa 2429401 aacagcttca cttgcttggg cattagggga tgcagggctt ggcattatgg tatggctgaa 2429461 cgtcattgcc attgtgctgc ttgccaagcc ggcgctcctt gctttaaagg attatgagcg 2429521 ccaaaagaag cagggcttag acccgatctt tgatccaaaa gcgctgggta tcaaaaacgc 2429581 tgatttctgg gagaaagaat acactcatga aagtgaacgt gtctcctgaa catactaaaa 2429641 ccggcccgat atgacctcgt gccggttttt tatgaacgat agtttgtata cacttcttga 2429701 acatcatcgt catcttcaag gacgtctatt aatgtttcca gcttctcaac agcctgatca 2429761 tcggcttctg cataggtatt gggaagcatg gtcacctccg ccgaagaaat tagatatttc 2429821 gattcgaggg ctgttttcac ctcttcaaaa tgctcaggct ctgtgaaaac ctcatatagg 2429881 tcttcttcaa ttcgcagctc ttctcctcct gcttcaagca catcaagcat gagctcatct 2429941 tcttctattt gccgttcagt acggtctatc gtaatgaacc cctttcgttc aaataaaaag 2430001 gctacacatc cgctttctcc cagacttccg ccatttttat taaaggctgt ccgcacattt 2430061 gacgccgttc ggtttttatt atctgttacg cattcaacca tgacggcaat ccctgaaggg 2430121 ccgtagcctt cataggtgat ttcttcatag ctgcttccgt cttggcctcc cgcagctttt 2430181 ttaatggccc gatctatatt ttcattcggc atattggcgc cttttgcttt ttcgatgaca 2430241 agacgcaatg ctgaatttgc ttctggatcc gctccgcctt ctttcgctgc cacatagatt 2430301 tcttttgcca gcttcataaa tattttcccg cgctttgcat cctgtgcatt ttttcttttt 2430361 tgaatgtttt tccacttgga atggcctgcc atgttttcac cttcttttac attttctatg 2430421 tacactttaa tgggaaatgt tcgctgatgc aaagaaaaag gctgccgaat atcacttccg 2430481 gcagcccttc cttcctagcg gttgttcatt ttatgaagtt ttctgaacag ccctttatct 2430541 gttgatactt ggacgtcacg gccatttgca tagttgcgcg ctgcttttac aacattatct 2430601 ctgtcagact ttgtgaactc tctgtggctt ttgactgcga taactactcg gtcatccgat 2430661 accataactt gtgtgtcatt gacgtttttc acttgtttca cacggttggc aatttttgca 2430721 gccagtcttc tgttttcttg gttgtcatac ccgttgttcg ctgcattccg attcatgttt 2430781 cggttattcg tgttgttata tgttccgtca gttgccaaag gaacacgatc gtcagcagta 2430841 acacggtcac ggttatttac attcgtggtg tttcggttac cgtcgttctg atcctccatt 2430901 aattcagaaa caggaccatc gtggtcgatt ccgtctccct gtctatcggc gtcattttca 2430961 tttgtataat atccgattgg acgggtattg ccgttattgc gcgtatcatt catagcatta 2431021 tcgtttgctc cgcatgctgt taagccggct gtcattagaa tcaggctagc gatcgtcatt 2431081 tttttaccca atggaaaaac cccccgtgga cgaattgagc atgtttgctc gcttttatca 2431141 tgtgcgtatg gggggcatgt taagcgtgtc agttctctcc atttggcagt gatctgcttg 2431201 aaaacaaaaa aaggaacgat ttacatcgtt ccgaacgatc actcattttc ttcttccgga 2431261 cggccaaaca tttggtttac agaaggctgg ttcgtcattg gcatagaaac tcctgccgaa 2431321 tatgggtttg gatttgggtt agctgtgcca tatggcatat tagggcttcc ataagctccc 2431381 attcccgaat ggccaggtgc agagaaatat ggctgatgat caccgtcaca gccgcagtcg 2431441 tcatgatctt tgtatggcat gtaaccatga gccgcagcag gctggtatgc tcccattact 2431501 tggggagtgc cgtaataagg gccatacggc atatgtccat acggagatcc ataagccgga 2431561 gatgcgtatt gcggcgcacc gtatgaaccg taatgtccgt gatggctgtt ttcatgatgc 2431621 tggttttcat aacccgggtc atactgaggc gatacaaagc ctggctggta tccatgcatc 2431681 ggatgcattg gataagcttg tgccggatag tacggatagc ataatcctga tcctggaaga 2431741 attggcgaaa caggcaccgg acacggtacg aaatgagccg gataatgata ataaggctga 2431801 acagccggca tcggcatatt cggaactgtg tgatgaacgt tttcctcttc tataccgcct 2431861 acctctggcg cctttggcat attaggcata ttcggataat ttgcattttc catattactc 2431921 atagcctcct gttgtggaaa ttggtcttgc atatgataca tatgatccat atttccgtca 2431981 tgatgttttt tcggctcctc cggtttagga ggcgaccaag gctggaaaag ctgtttcata 2432041 tcataataat cgttcacatc agcttcaggg tacacatttt cctgcaaatt aggcatcggc 2432101 gggacatacg gcatggactt cttttctttc ggctttgtgt cttctacatc gacaacggat 2432161 ttaggcttct ctttcgcata tggatgttct tgcttcacac tcccggccgc aggacttttg 2432221 cccgcttttg gctcttttct gaccgggact ccttctgacg gcacttttat tttcattcca 2432281 ggcatgatta agtctggatt gctaagctgt gtattgagtt ttttcacttc ctcaacatcg 2432341 actccgtact tttcagctat tttccagagc gaatcgcctt tttgaacgat atggattttc 2432401 aacgttttcc cctcctatgc aaaacgtgaa cagttcagct gtgattacaa tatgtttctt 2432461 cacaacatat gcctgaacaa aagaagttat gagtaaagga agggaaaata tttctgatct 2432521 acgtgatcga aagcattcga ttcagggcaa ggagtgcatc ttcctgaatg gcttttggca 2432581 ccttgatgac gcctgaaggt tctccttttt caatttgttc cagcgaccac aacaaatgcg 2432641 gcaaatcaat tcggttcatt gtcaggcaag ggcacatgtc agggttgagt gattcgattt 2432701 gtttatctgg atgctcgtga atgatccgct gaacaagatt catttctgtc ccgattgccc 2432761 acttgcttcc cgccggagcc tggttgattg tgtcgataat atatttcgtt gatccgttat 2432821 catcgcttag tgtcacgact tcgtgtgaac attccgggtg cacaatgatc tgaatgtcgg 2432881 ggtctcgctc tctcatatca tggatatttt tagtggtgaa tttctcgtga acagagcaat 2432941 gccctttcca caaaatcact ttcacattcg tatgcccgga ttcagctact aattcatctt 2433001 tcatcggatc ccacacagcc atatcttcaa gcgcaatgcc cagatcataa gccgtatttc 2433061 tccctaaatg ctgatcaggc aaaaataaaa ttcttttttt ctgtgtaaac gcccattcaa 2433121 gcactttttt cgcattcgaa gaagttacag ttgctccgcc atgctttccg acgaatgcct 2433181 tgatctccgc agtggagttc acataagtta aaggtatgat cgtatctcca aatatatgct 2433241 gaagcttctt ccatgcccta ttggtctgct gcatgtcagc catgtcagcc atagaacatc 2433301 cagctctcat atctggcagg acgaccgttt gctgctcgct tgtcagcata tcggcggttt 2433361 ctgccataaa gtgaacgccg caaaatacga tataatccgc ttctttgttt ttttccgcta 2433421 cttgggccaa ttgcagggag tcgcctgttt ggtcagcaaa ttgtatcact tcatcctttt 2433481 gataatgatg gcctggtata aagagcctgc tgccgaactt tttcttaatg gcggcaacgc 2433541 gcgtttccat atcctttctc gatagttctt tataactttc gggcatcata tcattcgatt 2433601 gtttgatcac atcaagaatt gacataacag cattcctcca cagattcatt tgataacgta 2433661 acatccatgc tgatatctaa acttttgacg gaatgagtca gaaatcctaa tgaaatataa 2433721 ttcacacccg tccctttaaa agcaggcaaa gattctaacg taatcccgcc agaggcttca 2433781 gtttttatat tagccggtgt gagctttgca aaatgacgga ccgtatcagg cggacagttg 2433841 tcaaacataa taacatccgc tccagctgca attgcttccc gcagctgttc ctccgtttca 2433901 atttccacct cgatatttac catgtgccct gcggcctgac gggctttttt gcacgcctct 2433961 aaaatagagc cgcatgctgc gatatgatta tctttaatca tgatgccgtc atacaaaccg 2434021 aatcgatgat tatacccgcc gccggctctg acagcatatt tctccagcat tctgagcccc 2434081 ggtgttgttt ttctcgtgtc acaaatttta atctgttcat catccagaca ccgaacagcc 2434141 tctcttgtca ttgtcgcaat tcctgacagc ctctgaataa gatttaatac gacccgctct 2434201 cctgaaagga gcgcagctgc gggaccgtgt aactcggcaa tcacttcacc tttatgcaac 2434261 atgtccccat cttttttgtg taaaatgctt tgaacatttt cgtccaataa cgaaaagcct 2434321 tcttttatga tcgctgctcc tgcaaaaata ccctctgact ttgcaacaat ctccgcttca 2434381 cagctctgtt ctccaaaaat agactgcgat gtaagatccc ctgtcccaat atcctcaaga 2434441 aaaaagtgat tcagtaattt tttcagctgt aaatgattca ttgttccaaa tcccctcgtt 2434501 ttttctgatc ttcgttcctt tttttgtatg gacaatttgt cttccttgcc agctcacctc 2434561 agcatgagga aaatcggtgc ggaagtgagc ccctctgctt tcctcccgca aaagcgcaga 2434621 aaacgtcatc agctttgcag tttgccatag atgagaaagt tccatctgcc gaattgtgat 2434681 atccttcaca tttacttcct gaaaaggcag cgtatgaagc cagatgctaa gctcaatcaa 2434741 actgctttgt tcccgcagaa tagacatgtg gcttgtcatt ttgctttgca gttcatgccc 2434801 ctctatatcc ggcacctcgt agaagacact ggtttctagc cctgattgat attgcctgtt 2434861 ataaaccggt ttttggataa tatgctctgc tgcccttttt ccaaatacca gcgcttccaa 2434921 taaagaattg cttgcaagcc ggtttgctcc atgtaaaccg gagcatgctg tctcgccaat 2434981 cgcataaagc cccggcactg tcgtttctcc ccagcgatta actgaaacac ctcccattaa 2435041 gaaatgcatt cccggagcaa caggaatttt tccgctgtgg atatcaatcc ctgctttttc 2435101 acaaatagcg gtgatggtag ggaaacgcgt ttcaaaatca gaaatcgcac tgaagtctat 2435161 ataaacgcga tttccttttg ccatttcttc gtgaataacc cgtgagacaa tatctcttgg 2435221 agccaggtca cctaaaggat gccgttcagc cataatcctg cggccgtttt cgtctactaa 2435281 acatccgcct tcccctctga cagcttctga aacaagcccg taggaaacac catttttcac 2435341 aagcagtgtc gggtgaaact gagtaaactc caaatccgtt aattccgccc cggcccggta 2435401 agccagagaa agaccgtcac ctgtgacagt gagatcattc gtatggtgaa gaaacaggtt 2435461 tccacagccg ccggcagcca gcacaacttc gtctgcgtgc cttaccttga gccgcccttt 2435521 gctgtctttt gtcatgacgc cgatacatcg tccgtcctct ataagcaaat ctgctgccgt 2435581 ttcattctcg attaacttga ttttgctgtt gatccgtttg agcaaataat cgataagcag 2435641 cctgcctgtt gcgtctccgc ctgcatgaaa tatgcggttg tatgagtggg ccccttctct 2435701 tccaagacaa acaccgcctc gttcattgcg gtcgaatgga aatccacgct ccaataggct 2435761 ttgaaccatc atttttccat catgtaatac gtctgctaca atagctagat tattatggcc 2435821 gcaccctgcg tataacgtat cctccagatg ggcttcaatc gagtcatctt ttgcataggc 2435881 cgcagcaatc ccgccttgtg catagacaga attgctgttt ttgacgcttt tttttgtgat 2435941 aacagtcact tcgtatgagg gcgggaaagc tgcagctaag gaaagtgccg ccgcccctga 2436001 accgatgact gcaatcgtct ttttagacat atgccatcct cctgttgttt acacctgtct 2436061 tgacacctat atttacacaa ggataaaata aactcaagag ttttttatgg agaacggatg 2436121 gaggaagacc ggatgattta tttagattat gcagcgacaa cgcctatttg tgaggaagcc 2436181 cttactgtat atcagaagct tagtatggat atgtacggaa atgccagcag cctgcatgat 2436241 gcaggaggaa aagcaaagca catactggag tactgccgtg aaaaaatcgc caacatcatt 2436301 ggcggagaag caagcggcat ctattttaca agcggcggca ctgaatccaa ttttctggcc 2436361 attcaatcat tgttaaacgg cctgccaaaa acgaaaagac attttattac gactgccatg 2436421 gagcatcagt ccattcataa ttgcgctgct tttttggaac agcagggata tgatgtaaca 2436481 gtcattgaac cgaatgaata cgggcttatt accgaggaaa tattactaac ccatatccgg 2436541 ccggaaacag gccttgtatc tattcagcat gcaaattctg aaaccgggat cattcagccc 2436601 attcaacacc tgtcttcata cctgcacaat aaggggattc ttcttcattg cgacgctgtt 2436661 caaacgtttg gaaagatccc gatcaataca aaaaatctgg gagtagatgc actctcaatg 2436721 tccagccata aaatccacgg tcctaaagga gtaggggcgg tctatatccg gccggatgtc 2436781 ccttggaaac ccgtttatcc tctgactact cacgaatacg gattcagagc cggcaccgta 2436841 aatgttcccg ggatcggtgc cttcactgcc gctgcagaat tgatcgtaag cgaaatggaa 2436901 aaacagatat cccgcaatga ggcattaaga acatactttc tagaccaaat ccgtattcgg 2436961 tctctccctg taacccttgc agcagacact tcgaaagcag aatgtcttcc gcatattata 2437021 gggtgttttt ttcactcatt tgaaggacaa tatgttatgt tagaatgtaa tcggagtaat 2437081 atttgcattt caaccggcag cgcttgttct gcaggttacc acggtccgtc tgaaacaatg 2437141 aaagcattaa gaaaaaccga acaagaagct ctgcaattta tccgcatctc ttttggcagg 2437201 catacaacag ctgaacagct ggaacagtta ttacatacgt ttacagtgct ttgggaacaa 2437261 aagaaaggag aatttgatat tgaccgaaga attaaagcta atgggcgcca acaggcgtga 2437321 ccagcttctt ctgtggctga aggaatctaa atcaccgctg acaggaggag aactcgcaaa 2437381 aaaagcgaac gtctcaagac aggttattgt acaggatata tcgctcttga aagcgaaaaa 2437441 tgtaccgatt atcgccacaa gccaaggata tgtatacatg gatgcagccg ctcagcagca 2437501 ccagcaggca gaaagaatca tagcatgtct gcacggtcct gaacggacag aagaggaact 2437561 gcagctcatc gtcgacgaag gcgttacagt aaaagacgta aaaatcgagc atcccgtata 2437621 cggagattta actgcagcca tccaagtagg cacccggaaa gaagttagcc atttcatcaa 2437681 aaaaatcaat tctacgaatg ctgcctactt atcacagctg accgacggcg tgcacctgca 2437741 tacactgaca gcacctgatg aacatcgcat cgatcaagcc tgccaagccc tcgaagaagc 2437801 cggcatttta attaaagact aaaaaaagcc ctctagtggg ctttttttat aattggtaag 2437861 actggtatgc acccagaagc ctcactttgc agccgagtgc ttcaagctcc tgcatggccc 2437921 ctggaatcaa tacatcatca aacgctttct caatatcaat aataaagaaa taatggccta 2437981 atccggtttt agtcggacgt gactcaattt ttgacaggtt taaatttctc caagaaaatg 2438041 cagacagcac tctatgcagc gccccggact gatcatcctg cggcagcatg accattaagg 2438101 tcgttttggg cctagagctc aattttgaat tcacttcaaa agatatgttt tcatcgggag 2438161 acaggataac aaatcttgta tgattgtccc tataatcctg tatatcccgt ttcacgattt 2438221 ttaattcgta tgtagaagct gccatatcat tggcaatgac cccgatattc agctcgggat 2438281 ggtcactgac aaactttgct gccgccccgg tagaattggc gtattcatat ggaacggaag 2438341 gaaaatgtcg atgaagaaat ttatggcatt gcgcaatcgc gtgtgaatgt gagtaaattt 2438401 tgtcgagctc tttccatgca ttctctcttg agggatggac gagcaagtgc tggtgaatcg 2438461 gcaacgtcat ttcacccacg attggcaaag gctgttcatg tattaaatag tctattgtta 2438521 gattaacaga tccttctaaa gcattttcca aaggaacaaa agcaaaatca acttcgcctg 2438581 caacggctgc atctatacac tccggaatgg tgcggtaagc aacatgttcg gcgccgtttt 2438641 gaaaacaaga actgactgct agatgtgtaa atgtagctgc tggacctaaa taaccgactt 2438701 tcatgacgat tttctctccc ttatgcacct gaacctaata tttcaacctt ttctacaaaa 2438761 tcaaacttcc tgagcttatt cattaatgta tgaatgtctt cttccattgc cgacgtactg 2438821 atagacagtg tcacatttgc tctgccttga agcggaatgg tctggtgaat ggaaagaacg 2438881 ttgcttccag aatcagctac cgcctgaaga agctgagata acgcacctga cctatcctcc 2438941 aaatgaaaga aaagtgtgat aatttgttct tttaccatgg tgtagaatgg aaaaacagca 2439001 tccctgtatt tataaaacgc acttctactt aaatcgacct tttgaacggc atctgctact 2439061 gaatctgctt tttttcgatc aagcagcttt ttgacttcta atgtttttct cattgcatcg 2439121 ggcaatacat cttcacggac aagataaaat gtctcctctt tcatttgcat ccccccttta 2439181 aaatagagag cctggcacca ggctctcttt tcagccaaca ttgattaatc aataaattca 2439241 aattcaaatt ccagaagcct gattatatct ccatccttgg ctccgcgttc tctgagtgct 2439301 tcatcaacac ccattccgcg catctgtctt gcaaaccgtt taaccgattc atcacgtgag 2439361 aaatcagtca tcttgaataa ccgctcaagg ctgtctcctg aaagcacaaa tacaccgtct 2439421 ggatcgcgtg taatgttaaa tggcacttct tcattttcca tcgtgtacat gacacggttt 2439481 tgtgtaagct cttcctcgtc atacagcggg aattccggtg tgttctcaag ctgattggca 2439541 acctcaaaca gaagctcacg cagaccttct cttgtcaccg cactgatcgg gaataccgga 2439601 taatcatccg tcagcttttc tttaaaggct tcgagatttt ccgcagcctc cggcatgtcc 2439661 attttatttg caacgataat ttgcggacgc tcagtgagac gcagattgta ctcgctcagc 2439721 tcctggttaa tcgtaagata atcatcatat ggatcacggc cttctaagcc tgacatgtca 2439781 atgacatgaa caataaccct cgtccgttca atatggcgca aaaactggtg gcccagtccg 2439841 acgccttggt gtgcgccttc aatcagccct ggcaaatcag ccatgacaaa gctgcgtccg 2439901 tcatccgttt caaccatgcc gagattcggg acaagcgttg taaagtgata gtccgcaatt 2439961 ttcggttttg cagatgagac aacagacagc aaagtagatt ttcccacact cgggaacccg 2440021 acaagtccga catctgcaag cacttttaat tcaagaacaa tgtagcgttc ttttcccggc 2440081 tcgccgtttt ctgaaagctg aggcgcggga ttagccggtg tagcaaagcg gctatttcct 2440141 cttccgcctc ttccgcctct tgcaatgaca gcccgctgtc cgtgctctgt taaatcagcg 2440201 atgacctgtt ttgtatcatc gtctgtcaca acggtgcccg gcggaacttt aatgaccata 2440261 tcatcagcat ttcgcccgtg ctggtttttg gacatgccat gctcgccgcg aatcgcttta 2440321 aagtgttttt tgtatctaaa atccatcagg gtgcggagac cttcatctac ttcaaaaacg 2440381 acgtctcctc cctttcctcc gtcaccgccg gcagggccgc ctttcggcac atatttttca 2440441 cggcgaaacg caaccatacc gttgccgccg tcgccgcctt ttacatatac tttgacctga 2440501 tctacaaaca taatgtcctc cgttctaaac cgttaaaaac tccgctagtc caacccaatt 2440561 tcaatcagac attcgtgact cgtgatttca aaacgcatga tatcaacgtc ctcatatcca 2440621 ttctgccgaa tatcatcaaa agcagatgga tcggcaaagg cgccgtgaaa atcaaggtac 2440681 agaatcagct gtctgtcagg atgatccgtt tgaagcgaaa ccgttaaatg attttcactc 2440741 tctctgctga ctgcttgatc aaacagatga aacagctttc tcatcagttt cgccagcttt 2440801 tgatcataag ccgacaaatc cttaatttct ccgagaactt catattcaag cgtcatataa 2440861 tgggttttcc aattaaacgt aagaaaatca aacgccaaat gcggtgtttt caggtttgag 2440921 agctttgatt cgtgctttgc gtctataacc atttcttcaa tcatttcaaa gacacggtca 2440981 tacttctgta agcttaagtt tcctttaatc agctgcagct tattcatcca atcatgccgg 2441041 gaatggccaa gcagatgaat cagttcgttt gttaatgccg tgtcgcttat attttcttct 2441101 tgattttttg aaacatcctt cattttcgca ctcccaatca tttaatttct tatttaggag 2441161 tctgtataag tgtgtattat gaattataac agagaaggct ttgttagaaa aacaattgtt 2441221 tttcccagaa atatcatgtt ccttttttct ggctttggtt gatttgcagc caggcagaac 2441281 attttatgta ttactgcttg gggaacatat ccagtgggtt tgagatgttt attctcattc 2441341 ttggcggggt ctgctcgcac atactctgca tttcattcta ggtgtttact ccgcatattg 2441401 caaaaaaaac tccagtcatc atcgaccgga gttttttgaa tcattattga gctacaggat 2441461 atacgctcac ttttttgcgg tcacggccga aacgttcgaa tttaacagtt ccgtcgattt 2441521 tcgcaaatag agtgtcatct ccgccgcggc ccacgttttc acctgggtaa atttttgttc 2441581 cgcgttgacg gtaaaggata gaaccgcctg ttacgaattg accgtcagca cgtttagcac 2441641 ctaaacgttt agcctcagag tcacgtccgt tctttgtaga acctactcct tttttagaag 2441701 cgaaaaactg aagatctaat ctaagcatgt agctcacctc ctatattatg tttgtggtca 2441761 cacgcaagtt gtctttgtaa tcccgttcga ttgtctccag cgaaacaatc atgccttcaa 2441821 tcagcagctg agctttttgg cgtgcctctg gatcaagaga ttcagggaat tcaaaataaa 2441881 aataaccccc gtcctctcct atatcaagaa gcggctcgaa gcccgcgagc acaatgaccg 2441941 cgttaacggc cccaaacaca acggctgtca ctccggcaca aacaagatct tgtccatgtt 2442001 cagcaaaatt cgcatggccc gtcatttcaa aagacaatat gcctttatca tgagaccttc 2442061 tgattgttgc ctgaatcatg cttacgcgtt gattttttcg atcgtcactt tagtgtaagg 2442121 ctgacgatga ccttgttttt tatgaacgtt tttctttggt ttgtatctga aaacagtgat 2442181 ttttttcgcg cggccttgtt tttcaacttt agccgttact gttgcgcctt caactgtagg 2442241 gttgccgact ttcacgttgt ctccgccaac aaacaaaacg tcttcaaaag taactgtttc 2442301 acctgcttca gcagcaagtt tttcgatgta aacagtttgg ccttcttcaa ctttgatttg 2442361 tttaccgcct gttttaatga ttgcgtacat tctctgcacc tcctattaga ctaagactcg 2442421 ccagatacca gggggctgta aaagctctta acacctgtac tgagcggttg tagcaatggt 2442481 gctacatcca taacattaaa aaatatacca aaatacaagg cgtttgtcaa tcagttttag 2442541 tagggcagaa gcagttcctc catggaagaa ttcgtccgct tatcggcaaa gtaagcgtgc 2442601 agcacttcat tctcgtcaag ctggctgagc ttttggcctg atttttctat aataatcgga 2442661 tgcttacagc cacgtttgaa ctcggccatc acatgataga ctttatcctc cgcctttact 2442721 gtcagcggca gaagtttctc aagctccctg ttttttccgt aatacctttc gaggagaaat 2442781 ctcacatgga tatagtgcct ttgccgatat tcctcaaaca aggaaacagc cagaaagaca 2442841 aacaaaaccc atgcgctgat ttgcagagga atcacgaata aaacccagca cccgagcagc 2442901 aggcagaagc agagcgacgt ttttagatta agccggtgag ccttttgaaa aggcagctgt 2442961 ttggaaaaca acaaaaataa cagttttcct ccatccagcg gccagatcgg cagtaaattg 2443021 acaaataaga tagaaagatt ataaaaggtg aagagttcaa aggtatgctg atgaatcact 2443081 gagacttctg caagcatcca ggcggcaaac tgaagccaga tgtgctgaag aggtccggca 2443141 ataatgaccg caaactcttc ctttaacggc cgattcccgt gctcttccac ttcgaccgtt 2443201 ccgccaaacg gcagcaaaaa aacacgcttg attctccaag aaaaaaacac agccagagca 2443261 gcatgcccca gctcatgaat caatacaatc aggagcagac ataataatgc tttcatatgg 2443321 cctgtgagca agcccagcgc cgcaataatc caaagaaaag gatgcacatg gatctttaag 2443381 ataaggtcga gccatttatt caaatgaaat cacctgaatc ggatcaataa atttatcgcc 2443441 gtctttcatg gcaaaataat agaccccttt attatgatca tcaagcttaa tcgaaccgag 2443501 ctttttgcct ttatccacaa aatcatataa agcaacatcc acatctttga gctcgccata 2443561 gatactatag gtgttgtcag catgctgcac cttaaccgtc agtcccgttt ggctgtcttt 2443621 gctgacttca accacatagc cttcttttac gctatcaatc ttatcactgc ttgtttcgac 2443681 tttaattcct tccccattgt cctgaaaatc ctgctgtact ttcccggatg caggcgcgat 2443741 cagatctttg cctacttcaa tctgctgttc cttatttttg tgttcaggag ccaggaaagc 2443801 aagcggattt ccgaatttgg tttcgaacca atggcttgct gaagcaaatt gaaattcagt 2443861 ttcaaaggtt ttggctacgg cgggtttaat ctgactgacg ggtccaatgt ttgttttata 2443921 ggctatagct gaaacgagaa caaggcaggc cgacagaaga catttcagga taattgaatc 2443981 tgttttcacc aatgggtgtt ttccgttgaa tgttggcatg ttatcttcgt agaccggaag 2444041 tgttccatgc ttttcctgat ccgttaccat cacccaggac gggggtttct gcttttcaga 2444101 aactgtctga gtagagaaac gttttgagcc ggaaagctgc tttcttcttt tctctaatcg 2444161 ttttctgatt tcatctgctc tgtgactcat tgccatcatc ctttgcattc gttgggtttg 2444221 tacatcatat gtcttgtcca tggcaaatat tcggtttagt caagaacaaa gcaggcaaaa 2444281 acaaaaaaaa cctgacacag catatgcttt gtcagattct tctctttgat tctatcacat 2444341 taagatctta ctccgaaaaa tgacttaatc ttagccatca ttcctttgtt ttgctcttca 2444401 agcacctgta aaggaacaga ttcacctaag atgcggcggg caatattgcg atatgcaatg 2444461 gaagcgcggt ttttagggtc catcgcaatc ggttcgccat gattggaagc tttaatgact 2444521 tcatcatcat cagccacgat tccgagcaaa tcgatcgaca gatgctgtac gatttcgtcg 2444581 atatccatcg tgtcaccgtt tttcatcagg tgatttctga ttctgttaac aacgagccgc 2444641 ggcggttcaa tattttcctc ttgctccagc agtcctataa tacggtcagc atcacgaaca 2444701 gctgagattt caggcgtagt gaccacaatc gctttatcag ctccggaaac ggcatttttg 2444761 tacccttgct cgattccggc aggacagtct atgatgacat agtcaaattc ctgtttgagc 2444821 tcttggacca tgtttttaat ttgttcagga gcaacagctg tcttatcgct cgtttgagca 2444881 gcgggcatta aatagagcag atcatcgaaa cgtttgtctt ttacgagcgc ctgatgcatt 2444941 ttgcatctgc cctctacaac gtctaccaga tcgtaaataa ttctattttc aagacccatt 2445001 acaacatcaa ggttgcgcag tcctatatca gtatctacta agcatacgcg cttccctaaa 2445061 atggctaagg cggtaccgag gttcgcagat gttgttgtct tacctactcc gccttttccc 2445121 gaagttatta cgatagcctc acccaattca cattcctccc tcaagccttg ttagatcagg 2445181 tcttaaatga gccaaatgtt gaaggcgttc aatgaccata tttccgtctg tatctaaata 2445241 agcacattcc atttcgttcc ctttttgaat gtggtctggg gagcgattta acacatgatt 2445301 gattcttaat tgtgtcggaa gcatttcaga ggcggcgatg accgcttgat tatttccatt 2445361 gaatccagca tgcgcaattc ctttcagtga gcccagaaca aaaatgttcc ctccggccct 2445421 gactgttccg ccgggattca cgtcaccgat caggagcaag tcgcctttta cctgcagcac 2445481 ttggcctgaa cggacaattt ttgaaacaga aataatttcg gcttcctctc ttatctgctg 2445541 tgcttctttt ttagtaatga cttcactgtc aatagaatga acaaacaaat ctttctttga 2445601 cgcaatcaat tcggttagct gttcctcttg ctccttatat aaaaagcgat ttcccagctt 2445661 aacatgaacg ctgattttct ggccttttcc atcggtatat tgttcaattg acagcatatt 2445721 ctgaagacca tcgagaagct catcaaaaga acacgcatca tccagatgca atgttagtcc 2445781 attctttgtt ccttttattg ttacatattg ctgctttttg gtcttcacaa tattcacctc 2445841 aacaacatac tcatttcgtc aaaaaaagat aaaatccttt ttactcatct ctcaattctt 2445901 tctttagact cataaaaaac aatctaaatg gcagaacaag aataagagct gctgcaatat 2445961 ttaataaaat tgtcggtata aaccggtcaa gcacaaatcc gttaaacgtc ataatgtctt 2446021 tatgaatcaa agactgaatg ccgaatacgt aaaattcgag cagacagaca gccagaactg 2446081 ctatcaatat cactacaaat gcgtttgtat gcaacacttt aaacgctttt gaagccaaat 2446141 agcatagccc tgcaaaacca aacatgtaaa cgcctaatag acttgtatag ttcatgtcat 2446201 atagaaagcc aaaaataaat ccgtaaatca tcgcgtgttt ttggttgata aaagccgaca 2446261 tgaatatcaa tacaagcatc aaaaaacgcg gggcgagcac ttggtcatct gtaacgaaag 2446321 gaaaatgcac caaatctgta aaaatgcttt ccgcagaaaa aacaagcatc ataacgaaag 2446381 ggagaaggaa acgtttcacg atccttcctc ctctgtatcg acagtcggca cgtcacggtt 2446441 aacaacgatc acattattta aatctgtaag gtcagccgca ggttttacat aagcaacctt 2446501 cgttaatcca taggaatctg actcgatatc agtcacttca ccgattgtca gcccttctgg 2446561 gaaaacaccg cctgtccctg atgtttcaat aagatcgcct tttttcacgt cttgtttatc 2446621 cttacgctca ataattgtca tcttaagacg ttttttctct ttgtcatatc cttcgatcaa 2446681 gccgtagcct ttgctgcctt tttttccgga aatttttgtc gcgactctgt tattgcggtc 2446741 agtatcgctt aaaagctgaa cagcagacgt aaaattgtta agtccggagc ttttgatctt 2446801 gccgattaat gcgccttttt cgtttgtaac ggccatatct ttcgctacgt tttgctgagt 2446861 ccccttgtta atggtgacct gtttcgccca attatcaggg cttctggcga tgaccgttgc 2446921 taaaatcggc ttgtaatctt taatcgattt gacatggcca agctcgtcac gcaaggattt 2446981 gttttcttct tcaagctctt gaagcttggc ttcatattgt gtctgtccgt caagtttttc 2447041 tcttagacgc tcgttttctt tgtatgtgtt ttttaaatca ttgatgttct caaatattcc 2447101 tgcaaaaaat tcggcaggcg tatgaaaaat attttgaaat actcccgtcg tatcgccgat 2447161 cactttctca ggccaggtgg tattgcggcc gcccttcagc gaaaatccaa tcatagccac 2447221 caatatgata atacacagaa gtaatagcat taaccgctta ttcggcatcg tgttacacct 2447281 cttctattga actcccgatt atctagtttt ccctttgaaa agatggatgt gctccagtgc 2447341 tttccctgtt ccgatcgcta cacaatcaag cggatcttcg gcgataagga ccggcatttt 2447401 tgtttcttcg ctgatgactt tgtccaaatt gcgcaaaagc gctccgccgc cggttaacac 2447461 tatacctctg tccatgatat ctgctgcaag ctcaggcggt gttttttcga gtgtgctctt 2447521 cactgcttcg acaattgtag atacagtgtc gcgtagagcg ttagaaatct cttttcctgt 2447581 aatttcaatt gttttcggca aacctgtgag caaatcgcgg ccgcggattt ccatgttgtc 2447641 ggattcttca ggagcttctg cagatccgat ttccatttta atcgcttcag ccgtacggtc 2447701 accgatcatc agattgtacg tttttctgat gtagttgata atcgcgtcat ccatctcatc 2447761 accggctaca cggattgact gagacgttac gatgcctccg agggaaataa tcgcaacttc 2447821 tgtcgtaccg cccccgatat caacaaccat gcttccagtc ggttcccaaa ctggcagatt 2447881 ggctccgatt gctgcggcaa aaggctcttc aatcggatac gcgtcacgcg ctcccgcctg 2447941 tcttgtcgca tcgataacag cgcgttcttc aacagctgta atgcctgatg ggacacatac 2448001 cattacatat ggttttctgg caaacatgcc tttatttttt atggcctgat tgatgtaata 2448061 tttcatcatc gtcgccgttg tttcataatc agcgataacg ccgtctttca tcgggcgaag 2448121 agccaccacg ttgcccggtg tccgtccaat catatttttc gcatcatttc cgacagcgac 2448181 aatcgatttc gtatccgtct gcaaagcgac aactgacggc tctctcacaa caattccttt 2448241 tccttttaca aaaacaagcg tattcgcagt tccaagatct ataccaaggt ctctagcacc 2448301 aattccaaac atatgtatgt atcttccttt cttaaagcaa aaatacccta aagggaaaaa 2448361 ctcataaact ctattatagc ttaattcgac gaaaaaaaaa gtgttacaaa tatccttttt 2448421 cctttaaact cacaaatttt ttatccccga tcaccaaatg gtcaagcagc tcgatgccaa 2448481 tcaggtttcc gcattcaaac agccgtcttg tcacttcaat atcttccctg ctcggcgtcg 2448541 gatctccaga aggatgatta tgaacacaga taaaggaagc ggcagatcgt ttaaacgctt 2448601 ctttaaacac ctctcgcggg tggacaatag atgaattcag gcttccgata aatacggtgc 2448661 gtttatggat gacttgattt tttgtattta agtataaaca gacaaaatgc tcctgggtta 2448721 aaaagcgcat atcctccatg acaagattag cgccgtcttc cggggagcga ataacgaaat 2448781 gttcttcgtt ggctaattta tgaatccggc ttccaagctc aactgctgcc agtatttgaa 2448841 tcgcttttac cataccgatt cccgggatgc ttgacagctc ttcaaccgat gcttccttga 2448901 gcaggcgcag cccgtcaaat gagcgcagca gccggtttga caggtccaaa acagattcgt 2448961 gtttagtccc tgtccgcaat aatatagcca aaagttcatg attcgctaag ttctcggctc 2449021 cgactttcag gagccgttcc cttggctttt ctttcattgg gaaatctttg agttttaatg 2449081 gcagatcgtg tatgaccaag cactcctttt ctttcccttc ccgtttatag aaccgtcatg 2449141 cccttatatc aaaatggcga agagctctca ttgtttttga tataggaagg cccatgactg 2449201 aataataatc tccgtctatt ttctttacaa aaagcgcgcc tcttccttgg atgccgtatg 2449261 cacctgcttt atccatcggc tcttttgttt caatatatgt ccaaatctct tcttcactga 2449321 gggaccaaaa cgcaacttct gtcttatcat aaaaagtctc gctgtgattt tcagcttgaa 2449381 tgctgaccgc ggttattact gagtgacttc ggcctgaaag cctccgcagc atagaagcag 2449441 cttcttcttg atcctgcggt ttgccaagac attcgccgtc aaggcatacc attgtatcag 2449501 caccgataac gattgcatgc gggtggagat cagctacagc cttagctttt tgttttgcca 2449561 accattggac gttttcttct ggtgaaaagt ttcgatttaa tttttcttct acttcactga 2449621 caataatgga gtagggcagc tggagaagat cgaggagttc tttcctgcgc ggagattgtg 2449681 atgcaagtat tagcggtttt gtcatgttcg tcatcctttc agggtttgct taagaaaaaa 2449741 agatactcgt ttatcctacc aaatcacgag gcttgtcaca atttcagaaa aataactttt 2449801 tcatgacaaa ataaaaaaag cctgtcacta aaggacgaag gctcagggca ctatctctta 2449861 ttttacgacg gctaacagct cctgctgagc cttccacccg gcttcagcac ttggatcctc 2449921 taattccttt aaagcctgca aaatcgcttt tttctctcct gtttctgacg cttttgtttc 2449981 accaagcgac ttttctattt tctctacact cgcttttgta atgtcttcgt cgagaatcgc 2450041 ctttgctgca agctccgctg tttccttaaa agaatctgtc atatctgact ctattgataa 2450101 ggaaagctcc ttgcctcccc aggcttcaaa atcactgtcg attaaaacct gtcctaactg 2450161 ctgtgagacc tccttttcac ttgctaagcc tgcaataaca tacgtatacc cgtcatcctt 2450221 tgacagtgac acggcggaat atcctttttc ggtcaattgt tctgttaacg tttcggcgcc 2450281 cttttcattt gaaaattttc cggcttgcac agcgtatgtt ttgtatgtac cttcagtttg 2450341 tgccgcttgt ttttctgcgc ctgaggtttg tttatcagca gaagtatccc ctgcttttgc 2450401 cgtttggctg cctaaagaat cctctaaaga ggccggtgct gacgcttctt tattccccga 2450461 tatgtttaac gcgaataacc ctaatccagt gccaatgaca gccgcgaagg caatcgtcgc 2450521 ggccactctt tttaccggtt tggcagcccc ggtctttcct tttgcgtaaa gctttgtttt 2450581 tttcttttga aaaggaggaa caactttagg gtcctcttta aacaccttgt cctcctcgga 2450641 atcccaattg aattcatctt catcagggtg ttcctgggat gccgcaacct cttgttctgc 2450701 ctgtcttttt tcctcccaat ttgaaaatgt catgctttta ttcgcctctg tctcaggcgt 2450761 ctcttgttcg taaaccgtct cttcttttcc attaatcgtc accttgaggg ctttttctgc 2450821 ggctttactg ttttttttat tctttctttt tttcaattcc gcttcctccc ttcatttgct 2450881 tgaccgttct tgtcggcttt tcatgctaca cactttagca caggcaaaga aaaaaagaac 2450941 aagacttttg tcgccttgtc caaaaaacgt tcgtcaaatt tttcagcagt cagcccaatg 2451001 ccattttgat ataaaaagaa atgatagagt caccgtataa ataggctaaa atgctccctg 2451061 cggctatagc gggggcgaag ggaagcggct gccttttagc gagtctacca gtcagaacag 2451121 ctgccgctcc atataatgca cctatcaaaa ctgaaaagaa aaaggcagct gccagcattt 2451181 tcacaccaag cacaaagcca atcaccgcaa ataatttaat atctcctccc cctactcccc 2451241 catgggtgat tgcggcaatt acagccagaa acaaaaatcc ggctgccgca cctaacaggc 2451301 ctgcatacca ggaatcaagc ggagaaatca atctcgcggc cgccaaaaag ggaagaaaga 2451361 aaatcaatat tcgatttgga atcagcataa aatgaatatc tgtcactgca acaataatga 2451421 gaagagagat aaacaccaca gcgggaaaca gttccagcga tatgccaaag cgtattcctg 2451481 cggcggcaaa taaacacgct gtcacaagct ctgctgcggg atacataaaa gaaatcctat 2451541 gcccgcagct tttacattta cctttttgaa ataggaatga caggatggga attaattctg 2451601 caggagttaa tgttcgccgg caaaacgggc atgatgaacg gggcgcaata atagatagat 2451661 gtaaggggat acggcacccg gccgtatagt aaaaagaacc aaggataagc ccgaagataa 2451721 aaagaatgga tagcatagac aacacacctt tactcattga gttctggtat ggattgtagc 2451781 aaaatggaca tcctgagctc caattgggaa tattcaattt tacacatgaa aaaaacggca 2451841 gaatcttttt ttgattctgc cggagccgga tgcttttatt tcaacctttt tcgaatgtca 2451901 gaaataaagt aaagagatcc ggtaatcagc acaatttcat ttgagccctt tttactttct 2451961 atgaatttga ttacatcgtc tggatcttca ctccagcttt tattgctgat ttcacttgca 2452021 tcatagagat cttttgcaag ggaagcacgc gggaaatcaa aagaagcaaa atgaatcgca 2452081 tgagcaatgg tttccagtct tttaatcatg ttctgatacg gtttgtcctt taacgcgcta 2452141 aacaccacag aaatgcgtga attggcgaaa cgctgcttca tcgtttccgc cagcttttca 2452201 acaccttctt cgttatgcgc accgtctaaa tataccggag gatgttcctg aacaagctct 2452261 aaccgtcccg gccaagcagc cttcacaagc ccgctcctta acgcttcgtc actgatatgg 2452321 gcgatattct ccttattgag ccactccgca gccaaaatgg acaaagcagc attttgtctt 2452381 tgatgggtgc caatcagaga tgtccgaata tcttcatagc atttctcttc cgttttgaat 2452441 gaaaactgtt ctcctgcagg cagagcctct tcattgaaaa taacacatgc atcatgcaat 2452501 gactggaacg gcgcagcatg ccgttcggct tcatggcgga tgacctgtaa agcttccggc 2452561 tgggtaactg ctgtaacgat tggaatacct tctttaataa tgccggcctt ttctcctgca 2452621 atttcttcaa tggtgtttcc caaaatgttc atatgatcgt gtccgatgct tgtaatcaca 2452681 gttaagagcg gttcaaccac attagtagaa tcgaatctac cgcccagacc tgtttcaaaa 2452741 ataacaaaat cgaccttatg aaactctgca aaatataaaa atgcacaagc tgtcataatt 2452801 tcaaattctg tcggctgtcc gtattccgtt tgatcaaggg cttcaacgtg cggtttcatt 2452861 tgattgacga gtgctgtcca ttcctcatct gaaatcggta tcccgtttac gctgatccgt 2452921 tcattaaacg taataatata aggcgatgta aatgttccaa ccgtatatcc ggcttcctgc 2452981 agcatagaac ggataaaagc gacagttgat cctttaccgt ttgttcctgc gacgtggaac 2453041 gctcggattt ttttttcagg atgtcctaac cgcgccatca gctgtttcat tcgaccaagt 2453101 ccgggcttca ccccgaattt cagcctcccg tgaatccagc tgcgcgcatc ttgatatgca 2453161 gtaaacaatg ataatcccct cttttataag acaaggcggt ttctctagaa accgccccgg 2453221 cttttcatta acccttcagc tcagccattc gtttttgaac agcgtcacgc ttcgccacat 2453281 aatctttttc tttttcacgt tcttcatcaa ttacgtgtgc aggcgctttt ttcataaatc 2453341 cttcatttcc aagtttcttt tggacacgct caacttcttt tgtcagttta tcaaattctt 2453401 tttgcagacg ggcaatttct tcatcaatat tgattaagcc ttcaagcgga agaataacct 2453461 ctgctcctga gacaacggcc gtcatcgcct tatcaacagc ctcaatatcg gtgccgattt 2453521 taagcacgct cggattcgta aagcgttcaa catatgaacg gttcgcttcg aggcgggacg 2453581 ctatttcgtc tgtgcttgtt ttaatgtaca gttcaacctg cttgctcatt ggcgtattga 2453641 cttcactgcg gatattgcgc acagaacgga tcagctcaac aagaagcttc atgtcagctg 2453701 ccgcttcagt atcggtatgc tccggcacta ctgcaggcca ttgacttact gtaatcgatt 2453761 ccccttggtg aggaaggtgc tgccaaattt cctccgttaa gaatggcata aacggatgga 2453821 gcagacgcat cgtttgatca agtacgtaag caaggatgga acgggtagtt ttcttagccg 2453881 cttcgtcttc tccataaagc ggaagcttcg ccatttcaat ataccaatca cagaaatcat 2453941 cccaaataaa gttatataaa tggcgtccta cttcaccaaa ttcatatcgg tcagcaagct 2454001 gggtcacgtg ctcgatcgtt tcatttaatc gcgttaaaat ccacttgtca gcgactgact 2454061 tttcacctga cagatcaagc tcatcgtacg tcatgccatc catattcatt aatgcaaaac 2454121 gggaggcgtt ccaaatttta ttggcaaaat tccaggtcga ttccactttt tcatagctga 2454181 agcgcagatc ctggccagga gagcttccag tcgcaaggaa ataacgcaga gaatcggctc 2454241 cgtacttgtc aatcacatcc atcgggtcga caccgttgcc aagagattta ctcattttcc 2454301 ggccttgctc gtcacggatt aagccgtgga ttaaaacatc tttgaacggg cgctcgcctg 2454361 taaattcaat gccttggaaa atcatgcgtg atacccagaa gaaaatgata tcgtaccctg 2454421 tcacgagaac atctgtcgga tagtagcgtt taaagtcttc agccgttaca tcaggccagc 2454481 ccattgtgga gaaaggccat agcgcagaac tgaaccatgt atccagtacg tctgtatcct 2454541 gttcccaatt ttcgctgtct tccggcgctt caagtccgac atatagctcg cctgtttctt 2454601 tatgatacca ggcaggaata cgatggcccc accacaattg acgggagata caccagtcgc 2454661 ggatattttc catccagtgt aaatacgttt tttcgaaacg gtcaggcaca aagttgacct 2454721 tttcttcttt tttttgcagc tcaatcgctg catcagcaag cggctgcatg cgcacaaacc 2454781 attgtgtaga aagataaggc tccacaacag ccccgcttcg ttcactatgg ccgacagagt 2454841 gcatatgatc ctcgatcttg aagagaactc ccgcctcctg taaatctttc acgagctttt 2454901 tgcggcattc aaaacgatcc ataccttgat attggagcgc attttcattc atcgtgccat 2454961 cttcattcat gacaaggatg cgttctaaat tgtggcggtt gccaagctcg aagtcgttcg 2455021 gatcatgagc aggcgtaatt ttcacggcac ctgaaccaaa ttccatatca acatagtcat 2455081 caccgacaat cggaatttca cgatttacaa tcggcaggat caccgttttt ccgataaggt 2455141 gtttatagcg ctcgtcttca gggtgaacgg caacagctgt atcaccgagc attgtttcag 2455201 gacgtgtcgt cgcaatttca attgagcctg aaccgtcagc aagcggatag ctcatatgat 2455261 agaatgcgcc ttgaacatcc ttgtaaatca cctcaatgtc ggatagggct gtttttgtcg 2455321 ctgggtccca gttaataata tattcgcctc tgtagatcag gcctttttca taaagcttaa 2455381 cgaatacttc ccttaccgct ttgctcaagc cttcatccag cgtaaaacgt tcacgggaat 2455441 aatctaggcc aagacctaat ttcgcccact ggctgcgaat aaagtcagca tattcttcct 2455501 tccacttcca cgtttcttcg aggaattttt cacggcctaa atcgtagcgg gatttgcctt 2455561 cttcacgaag tttcgcctcc actttagcct gtgtcgcgat gccggcgtgg tccatgccag 2455621 gaagccacag cacatcatag ccctgcatgc gtttcattct tgttacaatg tcttgcagcg 2455681 ttgtgtccca tgcgtggcca aggtgaagtc tccctgttac gtttggcggc gggatgacaa 2455741 cagagtatgg ctcttttgtc tggtcactgc ccgcttcaaa aaatttgcct tttagccaaa 2455801 aatcatatcg gtctttttca accgctgccg gatcatattt cgtcggcatt gtttgttcat 2455861 tcgtttccat cataaccctc cagcatgttt aaaaatggct gagaacgaaa aaagagctct 2455921 tcatccctgt aaaaggacga aaagctcttt cgcggtacca ccttttttca tgaactcaat 2455981 cagttcatgc acttataacg gataacgggt gtttcccgaa tttctctact cttctttcaa 2456041 gaaattatgc tcccgggcga ccttccaatc agacaacata agaagccttt cagcaaacgg 2456101 cttctctctc tgcatgcgcc ttttttgtac tcttcccgtt ctaagcaggt gtatttatca 2456161 gctcattgta tacattattt atgttcttta ttatagtaaa agtgtttttg attcgtcaat 2456221 catcttttcc aaaaacaccg ctttctatac agatgggcag gcacctattg cccaagttta 2456281 catatgatgc ttgtaaatgc gtagaggagg atgcaccgtg aagaaacgtt tcagctctta 2456341 ttcgctgccg ccatgggtaa ggcaaattcg gcttgtatcc gcacaagtga ttattcccat 2456401 tacgattttt caaggaatca gaaccatttt ctttccgaca acctttgatg ttttgctgct 2456461 cgcaatccta atctttttag cttgcgccct tcatttagaa tggatataaa caaacaagtc 2456521 cgcgccatta agacgtggac tcgttttcag cctgaaattt tttctcttgt tcaatctgat 2456581 gaattttcat cacaaacggc tctatgtttt tcatttgcca ataagccttt aataattgtg 2456641 tacattcctc tttttcatgc tgtcttttcc cagtttgata accgttcagc accttgtaca 2456701 tggctgccgg atatgccata tagctgagaa aaaggctgac ttccgcttca cgcaaaggga 2456761 atgatttcgt atatccataa aaccattcga cgcattccgg acaagctttc ggaaagcctc 2456821 tgaacatttt tgtataaaag ccgagcaggt cgttttgcgg cggaccgaca gatgctcttt 2456881 cgaagtttgt aaaatatccg gtcccggcat cattatacag aaaatggtgt atagacaggc 2456941 tgccgtggtt cattacaacc cttgaaacgt ccttttcctt tgcggactca taccagtcct 2457001 ccagccgttc cagcgcaaag ttcaccgcgg aaatggtttc agaaaaatag gttatggcct 2457061 ggagttcaaa gggagaaagg taccattcct tctccgctct atccacaaac tgctcataga 2457121 aaattttatc ttgttcccac ttttttttcg tttgcccgta ataacgttca atctcatcac 2457181 gtctaacctt tagttcctgc gcggttctct cgtgaagacg ggctgtttct ctaaataaat 2457241 aagcatgttt ttgatcccgt tcttcctctt ggtcaaattg gagccaaggc attaaatagt 2457301 agatatctcc gtattgtatg cctgctgaga aaaactcacc gctatttgtt ctgtaaacgg 2457361 gaacgaatga acgaaagcct ttttcctcaa tcgccaccat atgatctgta aaatgcttgc 2457421 cgcgaccttc tttcaatttt ttcagggcaa atatgccgta gtctgtatac actttccaaa 2457481 caagaggact gacaggctca ataaattgag cagtcagtcc gtattcctga agaaccgatt 2457541 gggtatcttc catttcattc accacatttt ccgatcactt acggtttacg catggctatt 2457601 tttatattga ggaatataga gaatctgtcc tgcttttaat tcatcatcca aggctaaaga 2457661 attcatcctg atcagctgct gggatgtaat ttcataccgt tcgcataaac gctcgatcgt 2457721 atcttcctgc tgcacaatac aaattttcat tctcgaaaac tcatccgctt cttttgtaaa 2457781 gagttttgtt aaataaagag aattatcact ttcctttgtt tgaggttcct tcgtttcagc 2457841 agcaggagca accctaggaa cagcatccgt ttccttcctt tcagtctcag aagattcagg 2457901 cagctggaag gattgaaaag gtgtttcttc cttaggctct tcagctgatg gtgtttttct 2457961 cacttcaatt tcgaagctct cttcctcttg ttcttcctcc tccagcagct taggcgctga 2458021 ataaaaagaa tcctcctctt cttgttcagg caggaaggta cggtatgccg gttcaggcaa 2458081 ttcttcttga gatgcctcct ccgagcttgt tttttgattg aaatggaaat gtaaatcggc 2458141 attgtcattc tccatatata cagctgaagc tgtttctctg ctatcttcta tggagagagc 2458201 ggcctctgat acactctcca aagcttcatc cggttccgcc tcttcttggc aaagcgcagg 2458261 atcagcctga tccgattgag ctgcttcttc attttgagcc tcttggcgca gcgcatattc 2458321 atgattagga gacactgttg tttcctcttt ttcctttgca atcacagtct ctgaatgaag 2458381 ctcagcttcc aaagcaggcg attcttctgc tccaacgtgt tcacgaagct cagtctccgc 2458441 tggagagtct gcttcttcac gaacatccgc tattgcagct gccggctctg ccgtttcttt 2458501 ttttgcttta acgatctctt gaatctctat ttctgaagga tcaggttctg gctcagattc 2458561 ttctgtttcc gattcagcac gaacctccgt ttccggcaca gcaagctctt ctgactcttc 2458621 ttcctctttc acatcttctc tggcctctgg ttctgaagca accgattcag gcggctcaga 2458681 ttctgctttt tctgtctcca gttcttcacg gagccccgct ttcgagataa aaagttctgg 2458741 cggttcggct ggcggttcat gctgaagaac tgcttcctct gccgatgatg cacccggttc 2458801 ttctactaca ctatgtgccg gcggctctga aagctcttcc tccctgaatg ccgcaggagc 2458861 ttcatataaa ggtatctccg gctctttgtc ttgcgtatcg tccaaaagcc cttcgatcgc 2458921 taaatcagct tgaattgtta aaatgcgcga atccgtcaat tgatagtcaa atgcgtcaat 2458981 aaagacgaag acatcctgta aatggctcac tttatttttc ggaatggtaa tatccacagg 2459041 aaaacagtga gtcagttccg cacttccatc ctctctcttt ctgacttgtt caacaaaccg 2459101 cttatctgta taaatctctt cggtatgttt gttttgatct atgttgtact cacctgtaag 2459161 ttcaagcgat cctatgattg atacataatc atttacttcc tgaaccctaa tatcaggatc 2459221 taatgaaata gaaagcagtt cagaaacttc ctgtcctttt tggaaacaga tcgattcttc 2459281 tacagaaaat tgcaatcgat gattttgcgg caagttcata tcctcctttc atctaatcct 2459341 taaaattaga tgtcactaaa ggtgtatgta tgaactggag aaaatatgag tgggagagca 2459401 cgaaaaaacc ggcacaagga gtccttgata ccggttttca ctcttatctg cggctgatct 2459461 cagcaaatac tttctcagct gcctggattg tgttttcaat atcttcatca gtatgggccg 2459521 ttgagaggaa aagaccttcg aattgtgatg gcggaaggaa taccccttca tttgccatcc 2459581 ctttataata gcttgcgaac agcttcaaat cagatgattt cgctgtttca taattgatga 2459641 ctggttcgtt tgtaaagaag aaaccgatca tcgaacctgc acggttaaag gtatgcggaa 2459701 tgccatgagc cccggcggtt tttgaaattc cttcttccag tctgtcgcct tttttgatga 2459761 aattcttgta ggattcaggt gtcagctgtt tcaatgtctc taagccagcc gtcatcgcaa 2459821 gcgggttgcc tgacaatgta ccagcttgat agatcggacc gcttggagcg atctgctcca 2459881 tgatttctgc ctttccgcca taagcgccga caggaagtcc gcccccgatt acttttccta 2459941 aacaagtcag atcaggcgtt acgccgaagt agccttgagc gcagttataa tcgacccgga 2460001 agccagtcat cacttcatca aaaatcagca gggagccgta ctgctcagtg atatcacgca 2460061 gaccctgaag gaaaccttct tgcggcggaa caacacccat atttccggca actggctcta 2460121 caatgactcc cgcaatgtct tcaccgaatt gctggaaagc aagctttaca ctttctaaat 2460181 cattgtacgg aacggtgatg gtgtttttcg caatgccttc aggcaccccc gggctgtcag 2460241 gcagaccgag agtggcaaca cctgaaccag ctttaatcaa gagagaatcg ccgtgtccgt 2460301 ggtagcagcc ctcaaatttt aaaatcttgt tgcggcccgt atagcccctt gccaaacgga 2460361 gggcactcat tgtagcctct gttccggagc ttaccattcg tacaatttct acagatggca 2460421 cacgatcaat gacgagctta gccagttcat tttctacttc agtcggagca ccaaagcttg 2460481 tcccgtattc agccactttt ttgaggcttt ctacgacgcg gtcatttgta tgccctaaaa 2460541 ttaaaggccc ccatgacaag acgtagtcaa tatattcatt cccgtcaata tcaaagattt 2460601 tcgagccttt tccgcgctcc ataaaaatcg ggtccatgtc taccgattta aatgcgcgaa 2460661 cgggactgtt cacaccgccc ggcatgagtt tttgcgcttc tttaaaagcc gtttttgatt 2460721 tttcatagct tctcatctgc ctcaactcct gtcaactgaa taaaattact ccgcaagcca 2460781 tttcgctgcg tctttcgcat gatacgtaat aatcaggtcg gcacccgcgc gcttcatgct 2460841 tgtcaaaatt tccaacacaa tttctttttc tttgatccag ccgttctgcg ctgcagcctt 2460901 caccattgaa tactctccgc ttacattata agcgacgagc ggcaaagtaa actcattttt 2460961 tacgtcacgc atgatatcca tataagaaag cgaaggtttg acaatcaaaa agtccgcgcc 2461021 ttcctcaaca tctgattgtg cttcgcggag tgcctccata cggttggcag ggtccatctg 2461081 atatgttttg cggtctccga attgcggtgt gctgtttgct gcatcacgga acggaccgta 2461141 aaactcactt gaatatttaa cagcgtaaga catgatggga atattgacga atccttcttt 2461201 atcaagtgct tctctgatca ctgtaacaaa tccgtccatc atgtttgatg gcgcaatgat 2461261 atccgcacct gctttcgctt ggctgacagc tgtctgcgcc aaaagctcca gcgattcatc 2461321 attgagaatg actccgtctt tgacaagtcc gcaatggccg tggtctgtat attcgcacag 2461381 gcacgtgtca gcgacaacaa ccatttcagg gaagtgttct ttaatttctg tgatggcttt 2461441 ttggacaatt ccgtgatcat ggtacgcttg tgttccgcaa tcatcttttt cttccgggat 2461501 gccgaacacg ataacagatt gaatgcccag tttgaccagc tccgctactt catccttcaa 2461561 taaatctaat gatacatggt gaacatcagg cattgacgga acagcttttt tgccttccag 2461621 cccttcaacg acaaaaatcg gatatataaa atctgatgga tgcaaacgtg tttcctttac 2461681 catttctctc attgcttttg atgtccgcag gcggcggtgt ctattaaatg attgactcat 2461741 attctctctt cctctcttga catgctgcac attaactcaa gcatgccatc tattgtaaat 2461801 gtatcaggcg tatgcgatgt gatgccgtac gtcagaaggg catcatttgt taaaggccca 2461861 atgctgatac aggccgtccc attcgccttc cactttttta attcttctcc caagacatgc 2461921 ataaacgtat gtacggttga tgaactcgta aatgttacat agtcaaagga atattgaccc 2461981 gcagcgtctt tcaatgcctc aatgccttct tcatccggaa tcgtttcgta gagaacccat 2462041 tcctttactt caaaaccgag cgggacaagc tcttgtttta tcacatcacg tgacaaattc 2462101 cctttcatca cggtaatggt ctcccccggt tcagcatgct gcttaagagc gtcagccaat 2462161 tgttcagcaa tatactcctg tggcatcaca tcaaccgata cgttatgcat ttttaaacgg 2462221 cgcgcggttt tttcaccgac ggctgcaatt tttttatgcg cagggagaat aagctgattt 2462281 tccttcagat aagaaaaaaa gaagtctgcc ccgttcacac ttgtaaaaac aagccagcct 2462341 ggcgcggcaa gatcctctct tacctgttcc gcaacatcat tcggcaaagc gcggcgaaac 2462401 gtaatcaaag aggttaaaac cgctttaccg ccaagcgcct ccactttttg ctgaaatgat 2462461 gctgcctgtg ccttattccg ggtgacaagc actgtttttc ctttcaacgg aaaatcattt 2462521 tccatcctcg tcaagctccc gttttacacg atcaattaaa tcttttgctc ctttgtcagc 2462581 cataagagcg gcacagcgct ttcctacttc ctccggatcg tttccggtga cggtttcttt 2462641 aaaaatgatt ttgccgtcag gtgaagcgac aagacctgtc atttcaattt catcctgtcc 2462701 atttaacacg gagtagcccg cgatcggaac ctggcagccg ccctccatcg cgtttaaaaa 2462761 agcacgttcc gctaagacag tccgttttgt atattcatct gtaaactgag aaaacaacgc 2462821 caacagctct tcatccgatt ctcggcactc aatcgccagg gctccctgcc ccacagcagg 2462881 caaacagcgc tcaggctcaa ggaattcggt tacgacatct tgcttccaac ccattctgga 2462941 aaggccggca gccgctaaaa taattgcgtc ataatcctct gtttccagct tttgaagtct 2463001 tgtatctata ttacctctaa tccatttaat tgtaaggtca gggcgctcaa tcaaaagctg 2463061 cgcgcttctt cttaaactgc ttgtgccaat gacagcacct ttcttcattt ctgaaagctt 2463121 tacgcgattc tttgaaataa gggcatcacg cgggtcctcc cgttcaggaa tacagccgat 2463181 cacaaggcct tcaggcaaaa cagcaggcat gtccttcatg ctgtgcactg ccatatcaat 2463241 ctcttcgttt aaaagcgcct gttcaatttc tttgacaaaa agcccttttc cacccacttt 2463301 tgagagtgta acatcgacaa tccggtcgcc ctttgtcacg atctctttaa tttcaaaagc 2463361 aaacgaagga ttgatttcct tcagtttttg aataacccat tttgtttgag tcatagcgag 2463421 tttgctccgt ctggaaccta ctttaatcgt tctcatcatt tctttcctcc cgaatctgct 2463481 tgggacatcg tttaactgaa ccaatggaat tgcgacaggc ttccaagcag gaaataattg 2463541 atcatcagca ccagaaaaca agccgtattc cacagtgcag cgacctttcc ttgcagctcc 2463601 ttaatcagcc tgatataaag ataatagctg tacagcagca ggacgacaaa cgaaccaagc 2463661 actttggcgt caaaccaata cagcgtttct agtgagacat acgcccaaat gacgccgaga 2463721 atcaaactca gcagcagcat cggaacccca atgacattta aaacatacgc catataatca 2463781 agcttagata aatcttctat tctcaacagc cattttcccc actttttctt tttcagcaga 2463841 tgatattgaa acatatatag cacagaaaaa acgaaagaaa gggaaaaagc gccgtatgaa 2463901 agaatcgcca ttgtaatatg aatcaccaaa agctcggata caagctgccc ggaaaaagca 2463961 gctgactgct gctctgtcgg tgaaaatgtg tgaatggcga tcatagaaaa tcctataaca 2464021 tttgtaaaaa acacgataaa gtcaacacgt aaaagctttg tcagtacaag tgacagcgtg 2464081 acaagcaccc aggcataaaa ataaagtgcc tctgtcacat ttaataccgg aaaccgcccc 2464141 gtcacccaca taaaataggc caaatacacg gtttgcagag tccagacaat agaaagcaac 2464201 cagaaggcca tttttccagc cttccggttg tgttgaagaa aatctataaa ataaaagagt 2464261 acacttaacg cgtaaatgac gattgtcccc tcattaagtc ttgccattgc agtatcaatc 2464321 attcagcttt cactcactta caagtgggct aaagcccgct tttgattcag ccttcttaaa 2464381 agagtggacc ttctggctgc tttcaacggt tttcatcatt tgacggcccg cagcttcttc 2464441 aatatcaaaa atctgcataa acaacgcgag cttttcttca gaatcagcat ctgccgcaag 2464501 ctctttcacc tttaaaatcg gatcacgaag catttggtta ataatacttt tggtgtgttt 2464561 gttcaacagt tttttctctc ttgtgcttaa gtgaggcagc ttacgctcaa tgctgtccat 2464621 cgtttctgac tggatggcaa gcgccttttc gcgcaatgca gaaataacag gcacaacacc 2464681 aagtgtattc atccattgtt taaattccac aatggtttct tcaattaaca gttcaacttt 2464741 ttcagctgtt tctctccgct ctttcatgtt cgcttctaca atgccttcca gatcgtcgat 2464801 atcataaaga aaaacacctt caagatcatt cagcgccgga tcaagatctc taggcacggc 2464861 aatgtcgacc ataaacagcg gacgtccctt gcgaagctta ttcgcgtttt ccatcatctc 2464921 tttggacacg acaaattcac ttgcaccggt tgaactgatt aaaatatcag cctccgcaag 2464981 cgcgctttca agctgattca agcttctcgc ttcacctgaa aaacggtctg caagctcctt 2465041 cgctttcaag tatgttcggt taatgacagt gaccttgccg attccctgtc cgtgcaggtt 2465101 ttccgcagca agctcgccca tttttcccgc accgagaatc aatatgtgct tgcttgaaag 2465161 atttccgaag atttttttgg caagttcaac tgcagcatag cttactgaca ccgcatttga 2465221 gccaatgtct gtttcggcgt gagtccgttt gcccactgta actgcctgct taaacagctc 2465281 attaaaaata gtcccgatcg ttttttcttg ctgagctgtt ttaaagctgt cgcgtacctg 2465341 tccgagaatc tgcgtttcgc caatcaccat agaatcaagt ccgcaggcta cacggaataa 2465401 atgctcaaca gcggcatcgc tctcataaaa cgttaagaac ggtgacagct cttctttgct 2465461 taattgaaac caatcagcta aaaacttttt tatataataa cggccggtat gaagctggtc 2465521 gactaccgca taaatttcag tgcggttgca ggttgagaca atgatgtttt caagaatgct 2465581 tttctcttct ttcagctgca ccattgcttc tgccagctca ttcggctgaa aacttacttt 2465641 ttcacgtatc tcaatagggg cggatttata atctactccc acaacaagta tatgcatcgc 2465701 tctaattaca cccccaacac ccaatcttaa tttataatca ttctaacata gaactcatta 2465761 tttataataa ttataacata gtttctttca caaaatgtga acagatttta aaattcttat 2465821 gctatattag aaaaagcttc agggaaaaga agcattccta ttgacaatac caaaaacagc 2465881 agaaatttac tacacatcag ctctaaaaaa caagaaggtg atatgcatga aacaaaaatc 2465941 aattttattc ccttgtctgc tgcttgccgc ttctgtatat gcatggctag aaagcggcca 2466001 agccgaactg ttttcagggc aggatcaatg gcctgttctc ctcatgctgt taggcgcagc 2466061 ctttgtatat caaggaaaaa aagaagccgt cacaccccat ttttttatcg gtttgcttct 2466121 cttcgggatc ggtttacact tttttgccaa gccgaaatgg gtatggtggc cggatgattt 2466181 tgaaatgctc ctctttatga tcggcttctc acttctcgtt tcaaccgttc aaaaaaaaga 2466241 atatgtatat gaagctgtgt cgatgatttg tttttccctg tttttgtact ttttcaaaca 2466301 aattatggca tggcttgagt ctgcgcatat tccaacagcg cttctgaagg agtattggcc 2466361 gtttgtcttt attggaatca gtttattgtt attattgata aaacgaaaaa aatctatacg 2466421 ataaataaaa ccggtagagg atcctctacc ggtttatcat ttttttgatc gctccccaag 2466481 cttcgtcttt tccctttttc gtttctgaag aaaagaggat cagctcgtct tccggatcaa 2466541 tatttaatgt ttgtcggaca accttcgcgt gtttgtccca tttacctttc gggatcttat 2466601 ccgcctttgt agcgataaca ataacaggaa tgccgtaata ctttaaaaat tcatacatct 2466661 gtacatcatc attagatggc gcatgccgca aatcaacgat ctgcaccaca gcttttaatt 2466721 cctcgcgtgt cgtgatatag gtttcaatca ttctgcccca tgcttcacgc tcagactttg 2466781 acactttggc aaaaccgtag cccggcacat ccacaaaatg cagctcatca ttgataatgt 2466841 agaaattaag cgtttgtgtt tttcccggct ttgatgacgt tctcgcaaga tttttgcgat 2466901 tgattaatga attgataaaa gacgattttc ctacgttcga tcttccggcc aatgcgattt 2466961 ccggaagccc cccttcaggg tactgttccg gttttactgc actgatcacg atttctgact 2467021 ttgtgacttt catttcttct ctcctactaa ggcatgttcc aaaacctcgt ctaagtggga 2467081 cgccaatata aatgtcagcc cctccctgac gctttccgga atatcctcta tatctttttc 2467141 attatcttta ggcgcaataa tggtcgttaa tcccgctcta tgtgcgccaa gcgctttttc 2467201 ctttaagccg ccgatcggca gcacgcgccc gcgaagcgtg atttccccag tcatgccgac 2467261 ttcacgcgaa accgcccgtc ccgttaaagc agaaacaagc gctgttgcca tcgtaatacc 2467321 ggctgacgga ccatcttttg gcaccgcacc ctctggtaca tgtatatgaa tatcatactt 2467381 ctcatgaaag tcaggttcaa tgccaagttc ttctgttttg gatcgcacat agctgaatgc 2467441 agcctgagca gactctctca taacatctcc gagctttcct gtcaggatta atttcccttt 2467501 tcccggtgaa agcgatactt caatcgaaag cgtatctccg ccaacggttg tatacgcaag 2467561 ccctgtcact acaccaactt gatcctctgt ttcagcttgt ccatatctga aaatgcgttt 2467621 tccgataaaa tcttgaaggt tcttctcagt aaccgtaatt cgttttcgct cttcagcaac 2467681 aatggctttt gcagctttac ggcaaattgc ggcaagctgg cgttcaaggc ttcttacacc 2467741 cgcttctctc gtatagtaac gaataatatc aagaatcgcc tgatcacgca gctgaagatt 2467801 gcttttcttc agcccgtgtt ctttgatttg ctttggaagc aagtgatcct ttacaatttc 2467861 aagtttttct atttctgtgt agcctgcgat attaataatt tccattctgt ctctgagcgg 2467921 gcccgggatt gtggccaaat tgttcgccgt tgcgataaac agcactttgg ataaatcaaa 2467981 ggtttcttca atatagtgat cactgaagct gctgttttgc tctggatcaa gcacttcaag 2468041 catagcggat gatgggtctc ctctaaaatc agatgacatt ttgtcaattt cgtctaataa 2468101 gaagaccgga ttcagcttgc ccgctttttt catcccttga ataatacgtc caggcattgc 2468161 tccgacatag gtccgtctgt gtccgcgtat ctctgattca tcccgaactc ctccgagtga 2468221 gattctgacg aatttgcgtc ccaagctttt tgcaattgat ttggctaaag acgtttttcc 2468281 gacacctgga ggtcctgcca aacagagaat cgggcctttc agggattttg tcagcttctg 2468341 gacagccaaa tattctaaaa tacgttcttt tactttttca agcccgtggt gctcttcgtc 2468401 caagagacgt cctgcttctt tcaaatcaag cttatcatct gtttcatccg tccacggaag 2468461 agcaaccagc cagtcgatat agttgcggat cacagagctt tccgcagaac ttgacggaat 2468521 tttttcatat ctgttcaatt ctttaagcgc tgtttctttc acatgatcag gcatgcctgc 2468581 ttcttcgatt ttttccgtca gcgtctgaac ttcgccagtt ttgccttctt tatcgccaag 2468641 ctctttttgg atcgccttca tttgttcacg caagtagtat tccttctgcg tacgctccat 2468701 cgaacgtttg acgcgctggc cgattttttt ctcaatctcc agcacttctt tttcattatt 2468761 aataaaatca atgaccttgt tcagcctgtc tttgacatca gccgtttcta aaatatcctg 2468821 cttatccttt agtttaaggg gcagatgaga agcaacgatg tctgccattc tccccggctc 2468881 ttcgatatca gtaaccgcag cgtacgtttc ggccgagatt tttttagaaa tttttatgta 2468941 ctgatcaaag tggtctagca aagtccgcat caatgcttcg tcttctgtat cttttgaatc 2469001 atcttcatga ataagttgaa tgtcaaccga cgtgtaatcc tcgtgttcat tgtatttgac 2469061 gatatgggcg cgcttgaggc cctccaccaa cacacgaatc gtaccgttcg gaagcttcag 2469121 catttgctta atttttgtat aggtgccgac agtgaaaatc tcgtcttcac caggttcgtc 2469181 tatcgaaata tcctgctgag tggctaaaaa tatcatatga tcatgcatca ttgcctgttc 2469241 aagagcctga accgacttgt cacgtcctac atctaaatgc aaaaccatcg tcgggtacac 2469301 taataaacct cttaaaggga ggagcgggat gctgcgtttt aattcttctg ccatgtgact 2469361 gacacctccg tgactttagt atgaaccatt ataatacaac tttttcatcc ttgtacaata 2469421 aacggcatgg ttccattttc tataaaacag tctcctcgta gtataccctt tctttctgat 2469481 atgaaaaagg aaaagatgtc cttcatgaaa aaaaccctat tatcaaaata gggtttaaac 2469541 ggattcttta ttgatttcga tatgaaacgg tttttgttcc gttggcggat tcaccaaaat 2469601 ttcatcaagc acttcttgga acgtcttcac tgcaataatc tcgatcccgt caatctgctt 2469661 taagatggcc tgctgatttt catatgggat aatcaccttt ttcgcaccgg actgcttggc 2469721 cgcttttatt ttcggaatga cgcctccgat gggtttcaca agaccgttca ggctgatttc 2469781 gcccgtcatc gcaacggtat tgtcaatagg aattttgtgt atcgccgaga aaatccccgc 2469841 cgccatcgca atgcctgctg acggcccatc aatcggaatc cctcctggga aattgatgtg 2469901 aatatcataa tcagaaggct tcattcccat tgtccggagc acggttaata cattttcaac 2469961 cgaacccttc gccatgcttt ttcgcctgat cgattttgat tggctgccga tgctttcttc 2470021 ttcagctatt cctgtgatgt taattgatcc tttatcttga gccgcggtta cacttacttc 2470081 gatttccaga agcgatccgc tgttaggccc atagactgca agcccattta caatgccaac 2470141 ctgtggttca acaccgattt tttgctcgtg ctttggagta agctgactgg agtgaatgac 2470201 ccattcaata tcctcaatcg taatgtcctt tcgattctcc gttacagcca tccccgctgc 2470261 gatttgaatc atattgacgg cttcccgccc gttccgcgtg tagctggtca aaagatccag 2470321 tccttcttcg gagatatttt tttcaatttt atccgctgct gttttggcaa ccgttttcag 2470381 ctcgtccttt tcaagctcgc ggaaaaaaac ctccaaacag cgggaccgga tagctggcgg 2470441 aatttcgttt ggcattctcg tggtcgcgcc aatcaagcga aaatcagccg gcagcccatt 2470501 ttgaaaaata tcatgaatat gattcggaat ttgtgtattt tcctcactgt aatacgcact 2470561 gtctaaaaag acttttctgt cctcaagcac cttcagcatt ttattcattt gaataggatg 2470621 cagctcccct atttcatcaa taaacagcac accgccatgg gcatgggtga cagctccctg 2470681 cttcggctgc ggaatcccag cctgtcccat cgctccggcc ccttggtata tcgggtcatg 2470741 gacagagccg atgagcggat cggcaattcc tctttcatca aaacgggctg ttgtcgcatc 2470801 gagttccaca aagacagcct gctctttaaa cggtgattgt ttatgttttt ttgcttcttc 2470861 caacacaagc cgcgcagcag ccgttttccc aactcccggt ggcccataga caatcacatg 2470921 ctgaggattt ggcccgcata aagccgcctt taatgcttta atgccgtctt cctgtccgac 2470981 gatatcttta aagcttttgg ggcggacctt ctcagataat ggctcggaca agctgatagc 2471041 gcgcattttc cgaagctgct ccatttcctt ctttgattct ttatctatcg tgaccttttg 2471101 tgtcctttga tttttaagca aattccaaaa atacaaaccg atgatgatcc caaaaaacag 2471161 ctgaataaat aacgcgatcc ctgtccaact catggtggtc cctcctgaaa aacaatttat 2471221 gtatccaatt cattcctctg attgctagta tctcccatag aagacgggaa taaacgtttt 2471281 tccggaagag ttgcatgcaa aaaaacctcc tgagtgttac cactcaggag gtttgtgctt 2471341 atctttatgc agatgtttta tcttggctta cctcagtgcc gtcttttaat aagaggcgag 2471401 gaggctctcc gtgtgtcaca gttgccccgg tgattacaca tttttcaatg tcatcacgag 2471461 aaggcagctc aaacatcaca tcaagcatga tgccttcaat gatagaacgg agtccgcgtg 2471521 ctccagtctt gcgttcaatt gcttttttag caatttcaga aagcgcttct tcttcaaact 2471581 caagctcaac gttgtcaagc tcaagcattt tcttgaattg cttaacaaga gcgtttttcg 2471641 gttttgttaa gatcgcaacc aatgcttctt cgtcaagctt ttcaaggctt gcaataaccg 2471701 gaagacgtcc gataaattca ggaattaacc cgaaacggag caaatcttct ggaagcactt 2471761 ttgaaagaag atcttctttc tcaagatcag cagctttatt gtcggcaccg aatccaatca 2471821 ctttttggcc taaacggcgt ttgatgattt gttcgatacc atcgaaagct ccgccgcaaa 2471881 tgaacaaaat atttgttgtg tcaatttgaa tgaattcttg atgaggatgc ttacgtccac 2471941 cttgaggcgg tacgcttgcc actgtaccct caagaatttt aagcaatgcc tgctgtacac 2472001 cctcacctga cacatcacgt gtgatagacg ggttttcaga ttttctagcc actttatcga 2472061 tttcatcaat atagataatg cctttttcgg ctttttccac atcataatca gcagcttgga 2472121 tgagcttcaa gagaatattc tctacatctt cacccacgta tccagcttca gtcaaagatg 2472181 tagcgtccgc aatcgcaaac ggcacattta aaatgcgagc caatgtttgc gccagaaggg 2472241 ttttaccgct tcccgtaggg ccgattaatg aaatattact ttttgaaagc tcaacatcat 2472301 caactttgct gttggagtta atgcgcttat agtggttata cacagcaaca gcaagtgatt 2472361 tcttcgcttg atcttggccg atgacatatt cattcaaaat ttcgcgaatt tcctgaggct 2472421 ttggtacgtc tttaaattct acttcttctt ctgttccgag ttcttcctct acaatttcag 2472481 tgcagagttc gatacattcg tcacatatat atacaccagg tccagctaca agcttacgaa 2472541 cctgatcttg tgtttttcca cagaacgagc attttaattg tcctttttcc tcgttaaatt 2472601 taaacattct ttcacccctt aatcttgtct cactttttct tttaccggca gagcaaaaga 2472661 aaatgattct tgaaacgaac gagtatgtat tgcattttac catactttcc aaaaagacgg 2472721 taacaatgtg tttctgactt gcacattcta tatgtatgac aaaaaacagc cctgcattaa 2472781 ctatattgcc ccaagaaaaa gagataactc ataattgtac aaaacaaggc acgaatgatt 2472841 cgcgccctgt tttattagta ctattattat gcaccatatt aacggttttc tacaagaaaa 2472901 tcaattgctt tgcgaacttt taaatcttct ttcatcgcgt cagtagaacc gatggcttgt 2472961 ttaatatttt caacaggcat gttgtatgct tcagccattt ttgtaagctc agcatcaact 2473021 tcctcatctg atacttcaag gttttccgct ttcgcaatcg cctcaagagt caggttagat 2473081 tttacgcgtt tttcagcatc ttctttcatt tgctctttaa gcgcagcttc atcttggcct 2473141 gagaattgag tgtaaagctc aaggttcatg ccttgcattt gcagacgctg ttcgaattct 2473201 ttcagcatgc ggtcaagctc agtgtcgacc attgcttgag gcacatcgat ttcagcattt 2473261 tcagaagctt tcagaacaag ctcttcacgc aatttagcgt cagcttcgtt ttcttttgct 2473321 tcttctaaac gtttctttgt tttttcagtt aattcagcaa gtgtttccac ttcttcatcg 2473381 atatcttttg cgaattcatc gtcaagctca ggaagctctt tcgctttgat ttcgtgaatt 2473441 ttcactttaa acacagctgg tttgcctgca agatcttcag cgtggtactc ctcagggaat 2473501 gtcacttcaa catccttctc agcacctgct tcaaggccaa ctaattgatc ttcgaagcca 2473561 gggatgaatg aaccagaacc tacttctaga gagtagtttt cagcttttcc gccttcgaaa 2473621 gcttcgccgt caacgaatcc ttcgaaatca agaacaactg tgtttccttc ttcaacggcg 2473681 ccttcttctt ttacaacaag ctcagcttga cgctcttgaa gggcttttag ttcgttttga 2473741 acatcttcgt cagttacagt tgtgtcgtct ttttcaatgc ccaggccttt gtattcgcca 2473801 agcttcactt caggttttac tgttactttc gcagtgaaga ttaagctttc gcctttttcg 2473861 attttttcaa catcgatttc aggacggtct acaggctcga ttccagcttc ttcaaccgct 2473921 ttagggtatt ctacaggaag aagaatatcc aaagcatctt ggtaaagagc ttctacgcca 2473981 aagcgctgtt cgaataatcc gcgaggaatt ttacctttac ggaatccagg aattgaaact 2474041 tgttttacta cttttttaaa tgcatcatca agtgctgttt taaacgtttc agcatcaact 2474101 tcaaccgtta aaacgccttc gttgccttct tgtttttccc attttacaga catgtgtttc 2474161 cctccaaaaa tctattcagg ttgtgtcggt cttccattct aaagcaatca ttcggcttcg 2474221 tccaacaaaa acaaagctgc caaagatcag aatcattatg tatagatgtt aataatgaac 2474281 tgcaaagcct gtccaaccgt atttcttata acccgttata cacaaataca accactatat 2474341 tataacataa cacatagcgc tttcaactat atggcgcgat ttacaaataa gaaatttctt 2474401 caatatcttt taacattgtg caagcttcat cgagttctct gtctgtaaat tcatacatca 2474461 tatgaagttc ttcgctttca atttcaatcc cgtgcatctc gtaaccgact ttatgaaggg 2474521 cagccgccca aaggtcagcc gacagcaatt tcggctggaa cggatataaa acgtacaaat 2474581 gtcttctcca caattcttct actgctgcat ataaggttgg attttcattt ccaagtgtct 2474641 catctagcac cctgagaaca cggtgaagaa tcggcgcggc atcaggcgga acaatctctg 2474701 acggttcaat tgtcaacgac tcgccaaatt tactaatgtg tacaggttta ctgtactcat 2474761 gctcagccaa cagcatgaca atcatcgttt tgataatcgg atgggctgag gggtcttgga 2474821 ggattgtttt gagcaatcct gtatactttg ctacgttacg gtcttttaag gaatgaatga 2474881 gattcatttg ctcctcaggg cttgccagca ctttctcggt gtcaattgta tcctcatatt 2474941 cttcggccca agcctcgtcc tcacgatccg gatcggtcat tttccggctg aaatccagca 2475001 gcttataaaa ttgctcggca ctttctgccg gcagctgatt ttcttccaaa acggcttcaa 2475061 tggtgctttt gacttcttcg tactttttga gctgaattaa gatggtcatg tacacctgca 2475121 aaaccgtaaa ataatggcca taaccttctt tgagcatctt ctcgcacacg ctttctgcct 2475181 cttccagctc gcccagctct aaaaagcaga tggccatccc taagtgaaga tcggattcag 2475241 tatcatcata tttcatcgct tctgaaaaca gttcaagcgc ttcttgatac tttttttcct 2475301 tgagtgatga catccctttt tccacaaggc ggtctttcag atgaggaaaa ggaataattt 2475361 ttgcgttttt cttgtcatgc gtcataccta tattcctttc aggcatttat tttgttcaag 2475421 tgtatcaaca cctgtgaaca aaaacaagaa atgaaaggtt tcaccaggca aaaaaagccg 2475481 ccggacaaat accggccgct ttttcaggct tgaagccaag agcttctttg tgattcaaat 2475541 tgcttgattt catcttccag cagcagcgtt aatgaaattt catcatatcc gttgatcagc 2475601 atctctttcc aatgcggatc aacttcaaat gaaatttgat tgccttcact gtcatgaatc 2475661 agctgatttt caaggtcaac agtcatttgc aatgactggt tttcatactg gccgacaagc 2475721 tgtttccaat tgtcatatgg catgcggatc ggaagcatgc cgtttttaaa gcagttctga 2475781 tggaaaatat cagcgaatga cggcgcaatg ataattttaa acccataatc atcaagtgcc 2475841 cacggagcgt gttcacgcga tgacccgcag ccgaagtttt ctcctgctat taaaatggaa 2475901 gctccttgat aaacaggctg gtttaattca aattcagggt tcggttcacc attcgcatca 2475961 tatctccagt caaagaatgc aaaacgtccg tagcctgttc tttcaatcct cttcaaaaat 2476021 tgcttaggaa taatctggtc tgtatccaca ttgatccgat ttaatacggc tgctttcccc 2476081 gtatgtgatt tcaaaggttc catctcgcgc actccttaca caactgtttt ttcctgataa 2476141 aactttctga catcaacgaa gtgtccgtga atggcagcca tcgcagccat tgccgggctg 2476201 acgagatgtg ttcttgcacc ttttccttgt ctgccctcga agttgcggtt agaggttgat 2476261 gcacagcgct ctccctcagg aacaacatca ttattcatac tcaaacacat gctgcagcct 2476321 gactctctcc attcaaatcc agcttccaag aaaatctggt caagcccttc tttttcagcc 2476381 tgaagcttca cgctttggga tccgggcacg acgatggccc ttacgctgtc agctaccttc 2476441 ttccctttga tcatgtcagc agcctgtcga aggtcagtca tgcgggaatt tgtgcaggaa 2476501 ccgataaata cgtgctccac tttaatgtct tcaatttttt ggtgaggagt caatcccata 2476561 tattcataag cacgaatcgc ttctttttta tcgtcttctg cagaaaagct ttccggcgca 2476621 ggaacttcag aatcgacagg aagaaccatt cccgggttaa tgccccatgt caccataggg 2476681 gaaattttgt tgccgtcaag gacgatagat ttatcgtaaa cagcgcccgg gtctgtgcgc 2476741 agcgccttcc attcctctac ggccttgtca aattcttcgc cttttggcgt gtacttgcga 2476801 tttttgcaat attcaaacgt cacctcgtca ggtgcaatca aacctgctct tgctcctgct 2476861 tcaattgaca tgttacaaac agtcattcgt tcatccatcg tcatatttct gaatacttcc 2476921 ccagtgtatt caatgacgta gcctgtgccg aatttcacac cgtatttgcc gatgacagca 2476981 aggatgacat cctttgccgt tacccctttt tgaagcgttc catctacgcg cacttcaagt 2477041 gtttttggac gctgctgcca aagtgtctgt gtggaaagga catgttcaac ttcactcgtc 2477101 ccgattccaa atgcaagagc gccgaaagcg ccatgtgttg atgtatgact gtcaccgcac 2477161 acaatcgttt tccctggaag cgttaagcct agttcaggtc cgacgacatg gacaatccct 2477221 tgatccacac tgtgaagatc ggcaaggcgc acgccaaatt cctcacagtt tctttcaagc 2477281 gccgttacct ggcgtttcgc aacttcatcc tttatctcaa aacgattgac agtcgggatg 2477341 ttgtggtcca ttgtcgcaaa tgtgttttgg ggtcttctga cctttcttcc cttttgtctc 2477401 aagccttcaa atgcctgagg agacgtcacc tcatgaatga ggtgcaaatc aatatagaga 2477461 agatccggct ttccctcacc atgttttaca atatgctgat cccaaatctt ttcgatgatt 2477521 gttcgaggca tcatctttta tttcctccct ctacctagag ctaagaccgc ttaacgtaag 2477581 ctgtcacaca ttagaaattg tattttcact catgattgct gccttaactt cctctgtaat 2477641 ggcctgagtg ctgctgaact cttcactccg tgccaagtct cttgttcttt ttccagaagc 2477701 caagactttg tttaccgcat cttctacagc tttcgcttcc tcttcaagcc cgaaagatgt 2477761 tctcaaaagc attgccgctg acaatatggc tgcgaacgga tttgccatcc ctttaccggc 2477821 aatatcaggc gcggagccat gaacaggttc aaacagatga aggccagagc ttgataggct 2477881 ggctgacggg agcattccga gcgagcctgt aagcatggac gcttcatcgc ttaaaatatc 2477941 accgaacata ttttcagtca ccacgacatc aaattgattc ggtgcataaa ttagctgcat 2478001 ggccgcgtta tccacaagca tgtgctcaag cttcacatca ggaaattctt gtgcaacgtc 2478061 ctcagccact tcacgccaca gccggcttga ttcaagaaca ttcgctttat ctacagaggt 2478121 cactttgcct tttctggctg ccgccatttt gaagccctct ctgatcactc gttcaatttc 2478181 cgttcgctta taaaacagtg tatctactgc ttcctgctca ccttcagtgt ttacataacg 2478241 tttgctcggc tggccgaaat acaagccgcc tgtgagctca cgaacgataa cgaaatcaac 2478301 attatctata tattcttttt tcaaaggcga agcgtcagaa aggctttcaa ataccttcac 2478361 aggccgcaaa ttcgcaaaca aatcaagctg ttttctgatg ctgagcagcc ctttttccgg 2478421 tctcagttcc gaaggatttt gatcccattt cggtccgccg acagcaccaa gcaatatcgc 2478481 gtctgcattt ttacaagcag caacggtttc ctccgggagg gggttatgat gttcatcaat 2478541 agccgcccct ccaatcaggc catattcaaa ttcaaattca tggttaaagc gttcggcaac 2478601 acttttcagt acgtctgtcg ctgattctaa tacttcaggg ccgatcccgt ctccgggcaa 2478661 tagagcaata cgtttcttca agttaaccgt tctcctttct tttatgatcc gacagctgtg 2478721 tggtttttca atccgctcat attcgactgg aaaaccaatt gacggtttac tgcgttcaaa 2478781 taggctttcg ctgatgcttc taatacgtct tgcgctatgc cccgccctgc tgattctttt 2478841 ccgttcacca aaactcttac atacacctgg gcaaatgcat cttcgccttt tctattagac 2478901 tgaatgcggt agtctaagag ctccacatcc ttatcgatgc agcgctcaag cgtattgtag 2478961 attgcttcca cgcttccagc tccagttgca gcttcctgaa taagctgtgc gttttcttga 2479021 tttttcaaag atagagtagc cgtagggacc tgacttgttc cgtaatgtac ttgcagagaa 2479081 agaaattcat acccaatctt gcgatctgtt actttttctt ctaaaataag agaaacaaga 2479141 tcctcatcag tgatttcttt tttcttctca gtcaactctt tgaacatcgt aaagaattta 2479201 ttaatctctt cactgtcaaa ttggaatcct aaagcagtca gccggtcttt aaatgcgtgg 2479261 cgtccggaat gtttacctag gacaagcgca tctgcggtta cgccgacaag ctccggtgaa 2479321 ataatttcat aagtcgattt ttcctttaaa aagccgtcct gatggatgcc tgattcatga 2479381 gcaaatgcat tatctccaac aaccgctttg ttgcgcggga cagccatgcc tgtcagtttg 2479441 cttactaaat cacttgttct cttaatctcg ttcagcgtaa tacctgtttc gacttggtag 2479501 aaatcttttc tggtatggag ggctacggca atttcctcta atgccgcgtt tccggctctt 2479561 tcaccgatcc cgttcacagc gcattcgatt tgatcagcgc cattttcaat cgcagcaaga 2479621 gagtttgcga ctgccattcc caaatcatca tgacagtggg ctgaaagctt tgctttgtga 2479681 atgttcggaa cgttttcttt catatattta aagatatttc cgtattccgc cggggccagg 2479741 tagccgacag tgtccggaag attgataaca ctggcgcctg cgtcaatcac tttctcgacg 2479801 atttctgcta gaaacggcag ttcagtgcgg caggcatctt cagctgacca ttgcacaatc 2479861 ggaaaacgtt cttttgcgta tttcaccatt ccaactgctc tttcaatgac ttgttcacgt 2479921 gtcattttca gcttgtgctt caaatgaatg tccgatgtcg cgataaatac atgaattctt 2479981 ggttgagcgc catcctttaa cgcttcccaa gcagcatcaa tatcaccttt tacacaacgg 2480041 gccagaccag ttactgaaca atttttaatg gttcttgcga tttcctgaac agctaaaaag 2480101 tcacctcggg acgaagcggg aaatcccgct tcaatgatgt ctgccccgag tctttcgagc 2480161 tgcttagcta tggcaagttt ctcctgtgta ttcaagttca ctccagggga ctgttcacca 2480221 tcacgaagcg tcgtatcgaa aaaattaatt ttgcgcaacg gagaccaccg cttccttctt 2480281 cttgccttgt ttcacaaacg gcatcatttc acgaagcttt cttcccacta cttcgatttg 2480341 atgttcgttc tcgcttgcat tgatagcgtt gaaacgagga cggtttactt ggttttcgac 2480401 gatccactct tttgcgaatg taccgttttg gatatctttt aatacttctt tcatagattc 2480461 ttttactttg gcgtccacaa cgcgagggcc tgatacgaaa tctccccact gtgctgtgtc 2480521 agagattgaa tatctcattc ctgcaagtcc ttcttcgtac ataaggtcta cgattaattt 2480581 cagctcatga agacactcga agtatgcaag ttcaggctga taacctgctt cagttaaggt 2480641 ttcaaatccg gctttgacaa gcgcgcttaa tccgccgcaa agaactgctt gctcaccgaa 2480701 caaatctgtt tctgtttctt ctttaaatgt cgtttctaat acgcccgctc ttgcgccgcc 2480761 gattccttta gcataagcga gggctttgtc tcttgcttct ccagtcacat cttgatagat 2480821 tgcgaacaat gcaggtacgc cagctccttg ctcatatgtt cttcttacca agtgtcccgg 2480881 gcctttaggg gccactaaga atacatctac atccgccgga ggaacaattt gatggaaatg 2480941 cacgttaaat ccatgagcga atactaatga ttttcctgct gtcaattcat ctttgatttc 2481001 agcttcgtat actttttgct gctgctcatc cggaagcaga accatgatga tttcggcttg 2481061 ggctgccgct tcttttactg aaaatacttt atgtccgtct tcttgggctt gagtgaaaga 2481121 ttttccttgt ctaacaccga cgatcacgtc tactccgctt tctttaaggt tcagggcatg 2481181 tgcgtggcct tgcgaaccgt acccgataac cgctactgtt tttccagcca atacgttctc 2481241 tttgatatca ccgttataat atacttttac catttcaatc tctcccttgt tatgttttat 2481301 acaatagata ttgttttatt ggatgacgcc ttttgctggg ttcccctcgc aaaagccgtt 2481361 gtacctgttc tcgcgatttc tttaatgcca taaggtttta ataactcaat aagcgcttca 2481421 attttgttag attcacctgt cacctgaaca acgatgctgt ctctgctgac atcaacgaca 2481481 gaggctctaa acggttctat gattccatta atctctgttc ttgttgaagg tgcggagaca 2481541 accttgatta aggccagctc cctctggaca atcgattgat ttgtgatgtc tgtgactttc 2481601 agcacatcaa tctgtttgtt gagctgtttc gttaactgtt caacatcatt ttcaccttca 2481661 acatgaacga cgaaggtgat tctggaaacg ccggctgttt ctgtgtgtcc aactgtaatg 2481721 ctttcaatgt tgtaatgcct ttttgtgaat agaccggtga tccggtttaa caccccggag 2481781 cggttcacca cagtcaatgt gataattctt ttcaaggttt cacccccacc atttcatgca 2481841 gccctttccc cggagccacc atcgggaata ctttttcttc gctggcaacc cgcacgtcaa 2481901 tgacaacagg ttctcttgat gttaatgcct cttccagctt ttcctttgct tccgcttctg 2481961 atgaaattct gatgccttta atgccgtatg cttcggacaa tttgacgaag tcaggctgag 2482021 aagcgaattt agattctgaa taacgttctt catagaaaat ttcctgccac tgtctgacca 2482081 ttccgagaca agcgttattt aaaatcacta ccttgaccgg aagatttaat tcgcgaataa 2482141 catcgagttc ttgaagcgtc atttggaatc cgccgtctcc gacaaccgcg acaacagtag 2482201 catctttttc ggccagctgt gcgccgatcg ccgccggaag accgaatccc atcgttccaa 2482261 gtccgcctga cgtgacccat ttatctgctt tttggaacgg ataaaattgc gctgaccaca 2482321 tttgatgctg gcctacatcc gttgcgacaa tggcctctcc ttttgtaaat tgatgaatat 2482381 attcaatcaa tttctgaggt ttaaaacctt cttcttcatt atctacatac cagagcggat 2482441 actcttcttt ccattctgcg agctgttttt tccattcgct tgaatcgctt tgtttgccgt 2482501 cttgtttgat cagctcctgc aggacaattt tgctgtctcc gactacagga atctgtgttt 2482561 tcatgatttt tccgatttca gctggatcaa tatcgatgtg ggctatcttt gcgtttctgg 2482621 caaagtgttt caggtttcct gtgacacggt catcaaaacg ggcgccgata ctgattaata 2482681 gatcacattc atgaagggcc atattggctg tataagtacc gtgcattccc gccatcccta 2482741 ggaaaagcgg atggtcagcc gggaagcctc cgagccccaa aagggtgtgt gccacaggga 2482801 tttgctgctg ttcagcataa ttttttaatt cttctgacgc ttttccgtgc agtacgcccg 2482861 cacccgccag gatcaccggt tttttcgcac tgctcacggc ttccacaagc ttgcggatct 2482921 gcaaataatt cggctctgtt gtcggctggt atcccgggag attcatctca tgatcgtagc 2482981 tgaattctcc ttcaattgtt gctacatctt tcggaatatc aatcaataca ggtccgggtc 2483041 ttccagttgt tgcaatatgg aacgcttctt taatgatgcg cggcagatct tccggctggc 2483101 gaacctggta gctgtgtttt gttactggca tcgtaatccc taaaatgtct gcttcctgaa 2483161 atgcatcgct cccgattaca gaggttgcta cctgccctgt aaagacgact aacggcaatg 2483221 aatcaatcat ggcatcagca aggcctgtaa caaggtttgt cgctcccggc cctgacgtgg 2483281 caatgacgac acccggtttt ccggagaccc ttgcgtatcc ctccgctgca tgaattgctc 2483341 cttgttcgtg acggggaagg atatgtacca accctgaatt gtatagctta tcgtaaatcg 2483401 gaagcacagc cccgcccgga taaccgaaga tcatttctac tttctctttt tttaatgatt 2483461 caatcagcat taatgctccg ctcatcgtct gtgtacattc ggcagatgct gaatccacct 2483521 gtacattagt ccccatttta gttcctcctt ttggattttc atcctttaaa gatcatcttt 2483581 tcattagcta gatagctgat tattcaataa aaaaagccct tccgcccaca atcagccgcg 2483641 cagtaactgc gatagctaaa aggggcgaaa aggcttttct ttccgcggta ccacccttgt 2483701 ttacggcctg ttaatcggcc gtctcatgga tatttctatc cgctttagta acgagtgaat 2483761 caagttcacc cggccaagtc ctactgtcat ttcagactgg cactctgagg cgagttcacc 2483821 ttgtaaagct tcgccggttc tcagctaacc cggttctctg tggaaaactt tatcaaggct 2483881 acttatcctc atctgcgctt ttcatattca gccttcggaa cggctttcca gctgttcaag 2483941 aaggtcgttt gtttttcatt tttttagaat catactgcga tgattttcgc ttgtgaagct 2484001 tgcatttatc ttttgttgaa ctcatattac gccgctttgg acgcagtgtc aacagcattt 2484061 tttaaaatta ttagacaatt ttgattaatc aatctatatt gtatacgctt tcattattgg 2484121 tacaaaagga attgcaaatg ttaaaagttt ttataatttt tttattaatc tatcaagaat 2484181 acaccagaat tatttaattt tatataaaca tggaagattt tataacacga tatggttcgt 2484241 atatggattg agtctgacag atcatcttgc aatccatttc aatttcggat aggcacttct 2484301 cttgttccct cggcatacat taatgatatc ttgcaaagaa aaggtgatac gatgaataaa 2484361 tcatttgcag acatgcaagg atttcctgcg ggctttccaa gcttccccaa ctttccgcag 2484421 cagtactatc ctgctgtccc tcccttttac cagcaaagcc agcagccatt tggaggctac 2484481 ggatacggac agccgttcag tcaggcatac agcccgttaa ccactccctc tggaatgtac 2484541 tcctcattcc catacgcttc aggattttac ggacagcaat tttcaggtgc aggctttagc 2484601 ggccatggcg gcagcttaag tgctccagcg atacatgccg gcggattcag cggggcgcca 2484661 ggcgtacacg gaggctttag atattaaaga ataccacaag ggccgaacat ctattgcggt 2484721 ccttttattg ttttaaaacg acttcacaag tacagtcaca ttttctgtct ttatatttgg 2484781 aaacaggatg gaatatgatt aagatgaatt gaacgatatt ctgcacaatc cgtaagtttt 2484841 cgaggaggaa taaaattgca tataaaaata gacgatttaa ctggacgtca ggtggtttca 2484901 ctggtgaatg agcatttaca tagcatgacg cttatgtccc cgccagaaag cattcatgcc 2484961 ttaggtctag aaaaactaag agggcctgaa ataacatttt ggagcgcatg ggaaggtgat 2485021 gaactagctg gctgcggagc gctaaaagaa ctggacaccc ggcatggaga aatcaaatca 2485081 atgcgaacat ctgcatcaca tttaagaaaa ggcgttgcca aacaagttct ccagcacatc 2485141 attgaagaag ccgagaagcg aggctatgag cggttaagct tagaaacggg ttcaatggct 2485201 tcatttgagc cggcaagaaa attgtatgaa agcttcggtt tccagtattg tgaaccgttt 2485261 gcagactacg gtgaagatcc aaacagtgtg tttatgacga agaaattgtg agacggcttt 2485321 ataaggatag ataagtgcag gggaaggtct gtcttatcta tcttttttta tattcacaca 2485381 tttttcacct ttatgataca cgccaatgtt ttcaattttg tttaattcaa agaacagcgg 2485441 gaattacaaa cgacatgaac gatatcatgc aaattcataa aggaggagat tgatatgaaa 2485501 agcatagttg gtgtatatga aactccgcag gaaaccatcg cagcgattga aggcttactt 2485561 acaaaaggct atgattctga tgacatttct gttgtgacaa gccggcgaga tacagattat 2485621 ttggagtcac gtacaggaac agaagtcaat caagctatcg atgcacatca ggacgaatct 2485681 gaatcttttt tcgataaact gaaagattat ttcacaatgg atgatactgc tacacacagc 2485741 aaagcattat ccgacttgga tattaaaact gatgaaatag acaagtatca agaagatttg 2485801 gatgacggaa aacttctggt agccgtcgat acagatgcag atgtaattgc tcctattgat 2485861 aacggcaatg ccctttcagg cggcttttca agcacaaatg aattggatta tacaacgaaa 2485921 gaagaaaaaa cgatgccgct ccgggaagaa cagctgaagg tcgataagga agacgttcaa 2485981 accggcgaag tagaaatagg aaaagaagtg aaaacagaaa aaagagatat ggacattccg 2486041 gtgagacatg atgaaattta tgtcgaacgc cgtccagtgg atgaaaataa aacggacgct 2486101 gctcccgtca acgattcgga agagatcaga gttccaatcg ttgaggaaaa gctggaagtg 2486161 actaaaaaac cggttgtcac tgatgaagtg gttgtcggca aacgcactgt tgaagaaaat 2486221 gaacatattt ctgaaactgt gaaaaaagaa gaacctcgtc tgaataaaga aggaaaagtt 2486281 gacggcttgg atgatgatcc gttaaataac aaatgaaaat catagaccga caacaaaaaa 2486341 cctcaaatcc taaatggatt tgaggttttt cttttggtac gtcccaggag agattcgaac 2486401 tcccgaccga cggcttagaa ggccgttgct ctatccagct gagctactgg gacacgtttt 2486461 gtttttttgt ttttcgcttt aactatcagc gacaagattt attatatatg ggatgcaata 2486521 ataagtcaac ggttttttag aatttttttc atgaggaaga aaattttctt cctcatgaca 2486581 ttttcatagt gtgactcgat tttgcagatc ctcaatttca ttgcctgctt ggtcgtaaaa 2486641 acggactgtc gcagcatcat tttctaatgt cagtatagca tagctttctg tcctgcgcac 2486701 cctcggaagc cggatgctgc ctgggttaat catcagtttt ccgcgcagca cttcgcttcc 2486761 cgcgatgtgc gaatgcccga agcagataac atccgccccg agctcctctg cacgatagta 2486821 tacgtttaac aaggtctgtt ttataccgtg aaggtggccg tgtgtgacta gtatttttct 2486881 tgagccggca gtcagaagaa gctcgtcctt aaaatcgccg gcaaaatcgc aattgccttt 2486941 tacaaccgca taaggctcca atgcaggatg cctcgtctca agctcagagt ccccgcaatg 2487001 aatcatgaga tcaacttctg cctcatgccg tttcgcaatg gtttggagtt cttcttcaag 2487061 cccatggctg tcactgataa tcagcacgtt catgtacaag cttcctcctt atgcctccaa 2487121 aagcttagac agctttttaa gcgcgtcagc cctatggctg attttatttt tttcatcact 2487181 tgtcagttca gccatcgtct tatctttatc tttcacgata aaaattgggt catagccaaa 2487241 gccatattct cctctcggtt cttcagcaat atacccttca acatggcctt cgactgtttt 2487301 tgtttcctct ccgggaatac tcacggccag tgcgcagcgg aaacgggcgg tgcgctgttc 2487361 tttttcgata cctttcagct cgctgagcac tttttcgata tttgcctggt cgtctttctg 2487421 ttcccctgca tagcgggctg aataaacccc gggtctgccg ccaagattat cgatggatag 2487481 tccggagtca tccgcaatca ccattttgtt cactgctttg gcaacagctt ccgctttcat 2487541 aatggcattt tcttcaaatg tatggcctgt ttcttcaatt tcctctgtga atccaatttc 2487601 agctaaagat ttgacatcat agcctcttgg ctcaagaatt tctttgaatt ccttcacttt 2487661 tcccggatta tgtgttgcaa taattgcttc tttcatgatg atcaagcctt tctgtcttta 2487721 tttcagttct ggcagagaat cacccagcac ttctttttgc ttgtcaatca gctcttggat 2487781 tcctttttcc gcaagaccca gaagaccgtt cagatcctct ctagaaaaag ttgcctcttc 2487841 cccggttccc tgcaattcca caaaacggcc gctgcctgtc atgatgacat tcatgtcaac 2487901 ttcagcagag gaatcttctt cataatttaa atctaacaaa attccctgtt ccttatcaat 2487961 tccaacagag attgcagcaa gaaaatcagt gatcggattt gtcttgattg ttcctgcttt 2488021 gatcagcttg ccaatcgcaa tcgccatagc aagaaatgcg cctgtaatgg aagctgttct 2488081 agttcctcca tcagcttgaa tgacatcaca gtcaatccaa atcgtccgtt caccgagctt 2488141 ttccagatct acaacagctc gaagcgcgcg gccgatcagg cgttggatct ccattgttct 2488201 gccggaaatt ttccccttag aagattctct gattgttctt tggtttgttg cccgcggcag 2488261 catgctgtac tctgctgtaa tccagccttt ccctccgccc cgcaaaaacg gcggtacgcg 2488321 gtcctcaaca gacgcgttgc agattacctt tgtatttccc gctgttatta gaacagaacc 2488381 ttccggatgg ctgataaaat ccaaatcgaa tgtgattgga cgcagctcat cgtgttgtct 2488441 tccgtcatgt ctcatgtttt acctccgatt gtatgtacat aaaccatttt tgtcccggaa 2488501 ttgaataaag aaagaggcag ccggaacgct aacctctttc ttcctagtat atcaaaaatc 2488561 ccaatttaaa aactacccgt attcacttga gatggtctgg agaccggttc tgtgagcttt 2488621 tcgccttttt catttaccag ctctgatttt ccgttcactt taacagagac gctttttaca 2488681 tccggctgct ccgttaacgt cagcacaatg ctgttcagca cttctgaaga aatcattttc 2488741 gtcttctcat cggcgctgcc gaatatagat tgattgaaat ccaacgtcac gcgcccgtct 2488801 ttgattttcg gtttgctgac cagctttaca tcttcactga agtctgttaa cagcccgctc 2488861 accttgctcg gccctttagc caattcatta atggctgctg tgatgtcgtc tttttccgaa 2488921 ttgtcgattc gtttggtcac cggcacgtag tattcactgt cttcattttc cgccaaatag 2488981 tagactgtca gcggatgggt agcagtgaga tcatttacac cggctgtttc caaattaatg 2489041 ccgtctttgc ggcttaaatc atctgagatc ggcgtccctc ctacaggcat ctccttcagt 2489101 tcatgcccgt ttattctcag cttcacttta tctatcgaac taaattgcgt cagcgtccac 2489161 gtcacagatt gaacgatttt ctgttcgtct tctttcttat aatttttgaa ctcattagag 2489221 aaatcagcta tcgccgttcc atcttttttg atgtcaacgt taacggtggt gtcagccggc 2489281 aatacagctc tgaagccatt cggaagaatt tcagacacag gcccgccctg tacgaggtat 2489341 tcaagcgcct gcttagccgt gctctcactt ttaggaagag gcagcgtttg cgcaacaaca 2489401 tacccgtttt tatcaatgag ataaagctcc ctcataacag tagatgaggc ttgatccgct 2489461 tttgcggtat cgcttttttc actttctgtt tttttggctg ctgttgtatt tgaattggca 2489521 cccgcttcat cgttcacgaa tgtaacgtct tgaggcggat caatttcctc ggctgcctta 2489581 tcagattgaa acaaaccgca tccggataaa agcaaggcag aggtgagaca agtggcacca 2489641 atgactgcag gtcctttttt cagcatactt ttccctccta aggatgtttg tactattatg 2489701 tatacgagcc tctttaggaa atagaccgaa gaattccggc aaaacagaaa aaaacccgca 2489761 acataccgtt gcggggaaaa ctatctttta atcggttctt gcagtgagat acattccaca 2489821 tgcccgactt catggccaaa ccaatcgtct gcgatttttg caaactgatc acgcgcccct 2489881 gttgtcagga actgatgatc cggggcaatc ggagactggt tcagcagccc tttataagag 2489941 agaattgtgc tgacttcccg ggctgtttca tcgccggacg aaataatgtt tacgtgctct 2490001 cccatatatc tttgaatggc ttcttttaaa atagggtaat gggtgcagcc taaaatcagc 2490061 gaatcaattg atgtgtcttt taacggatac agcgaggttt taacaatctc gtctgctgtt 2490121 ttgtcgagaa acttcccgct ttccacaaaa ggcacaagca gcgggcaggc aaggttttca 2490181 accttcaaat cagggtttaa tgccaaaagc gcttcttcgt atgcattgct cttaatcgta 2490241 ttctctgtgc cgatgacacc gatatgctga ttatccgtca cttttatcgc tgctctcgca 2490301 ccaggctgga tgactccgac caccggtata ccgacgctgc gctggatgtc atccaaagcg 2490361 atcgctgttg ctgtattaca ggcgatcacg agcattttga tgtggtggtt ttcgagtaaa 2490421 taattcgtca gctcccacgt atattgaagc acctcttctt cagggcgcgg cccgtaagga 2490481 caccgtttcg tatccccgac gtagataata ttttctttag gtagctgtct catgatttcc 2490541 ttcgcaacgg ttaaaccgcc aaccccggaa tcaatgactc ctattggttg ttccaacaaa 2490601 atcgcctcat tttctcttca tttcatgctg cagtttcatc aaagattttt cgaagatggc 2490661 tatttcttca tctgtaaacg attcgaacat atcacgcaga tattcctgtc tttttgtaat 2490721 gacctcttgg ataatccgtt ctccttcagg cagcagatgt atcctgacaa cacgtctgtc 2490781 cgccgggtcc ttgacccgct caacaagctc atttttttgc atgcggtcga ttaagtccgt 2490841 tgtcgtgctg catgccagat acattttgcc cgataattca ccgattgtca tatctcctaa 2490901 ttcataaagc cattgcaagc cgacaaattg cggcggcgta atcgcatatt ggttaaggat 2490961 ttctcgtcct ttttgcttaa tgatcgcggc aatgtggcgg agtgactttt caatatccgc 2491021 aacatgctcc aaaggttttg atgtcatttg tccatccctc actcaaggat ctcttacgca 2491081 caaaagcgtt ccgtgtctat tttccttctt ttttgaagaa aatgcaagac tcgcaggaga 2491141 gaaatagagg actttagtca aacaacatca agaaataaaa tttaatttat gacttgccta 2491201 cgttttgcac agcattccaa atatggtttc gaatgttcca aacaaacagc aataaccggc 2491261 tccttccaaa agaaggaata ccggcaagga ttaaagctct agctcaccca ttctaagaag 2491321 ctcaacaacg gcttgcgaac gccctttcac acccaatttc tgcatggcat ttgaaatatg 2491381 gtttcgaacg gttttctcac tgataaatag ctcgcttgca atctcctttg ttgtcttatc 2491441 ttgaacgagc aattcgaaca cttctctttc tcttttcgtt agcagcggct tcgattgaaa 2491501 ttctttctcc ttcaagtatt gtaaccctcc ttgctaaggt gagagcgaat cagaaacgaa 2491561 tgggttttga tatagtcgag atatcatatg taagaagggc gcaggaggtg acgtttacaa 2491621 gataattagt ttatcgtgta tgaagaagcg tttctttctc ctcatccgtc cagctgacag 2491681 ccttgccgct ttcctttgag acttgaacca tcacgactgc cccggtgaag cagggttcgc 2491741 cttcgaggtt ctctccgaga tagtgcaagg taagagatga actgccgact gcgcttgttt 2491801 tcacatagat gcgcaactct tcataaggca tgacttggcg caaataatcg cattgctggc 2491861 ttgccacgac tgtcatggtc tgtttgtttt cactcatcat attcagcttt ttaaaataag 2491921 aaatccgcac ctcctcaaaa tatataaaag gggttacatt attcatatgc ccaaacatgt 2491981 ctgtctcgga aaatcttacg gataccttat tgaaaaaaga aaaggatgtt ttccattctt 2492041 gaaacggcat atcaatataa gcgggaagct tcatcttttt tcatctcctt attgtttaaa 2492101 aaaacctctc ccatgcggaa gaggtttttt cttcttatac tctgtcgctt ccgaagaaat 2492161 tgcggaacgc ttgtaagttt gtatctctat tcaaggctgc aatcgaagtg gtaagcggaa 2492221 tccccttcgg acaggattga acacagtttt gcgagttgcc gcaatctgca aggccgcctt 2492281 catccattaa tgcttctaat cgttcagatt tattcatggc gcctgtcgga tgcgcgttaa 2492341 acaggcggac ttgcgacatc ggtgcaggcc ccatgaactt cgatttgctg ttcacattcg 2492401 ggcaagcttc gaggcagacg ccgcatgtca tgcattttga taattcatat gcccattgac 2492461 gacgtttttc cggcattctc ggccccggtc ctaaatcgta cgtaccgtca atcggtatcc 2492521 acgcttttac ttttttcaat gaatcaaaca ttctgctgcg atcaacctgc aaatcacgaa 2492581 cgactgggaa tgttttcatt ggttttaaac ggattggctg ttcaagctgg tcaataagcg 2492641 ccgtacaaga ctggcggggt tttccgttta taaccattga acatgcgccg catacttcct 2492701 caagacagtt catatcccat gtgacagggg ttgtcttctc acctttgaca ttaaccggat 2492761 tccggcggat ttccatcaga gcggaaatga cgttcagatt cgggcggtat ggaatctcaa 2492821 attcttcatc ataaggcgtg ctgtcagctg tatcttgacg tgtgataata aatcgtatgg 2492881 ttttttgttc actcatgatt atttcgccac cttcttcttc gagtaatccc gtttccgagg 2492941 cgttatcagt gatacatcga catcctgata ctcaaattcc ggcgcttcat acgggcttac 2493001 atgtttagcc attgttgttt tgagccattc atcatcatta cgttcaggat aatccggttt 2493061 ataatgggcg ccccggcttt cattacggtt gtatgcgcca agggtaatca ccctcgcaag 2493121 ctgaagcatg ttcgagaact ggcgtgtgaa catcgctccc tggttgctcc attttgtcgt 2493181 gtcattgatg ttgatctttt tgaagcgctc cattaactcc tgaattttgt catccgtttt 2493241 caaaagcttg tcattatggc ggacaaccgt tacgttcgcc gtcatccact caccgagctc 2493301 tttgtgaaga acataggcat tttcggttcc gtccatactc ataatatcag cccatttttc 2493361 ttcttctttc ttaacgtgag cgtcgaataa agatgaagac atgtcttccg ctgaagattc 2493421 taagccgttt acatatttca ccgcattcgg accggccacc atgcctccgt aaatcgcaga 2493481 cagcagggag ttcgctccca agcggttgcc gccgtgcata gaataatcac attccccagc 2493541 cgcaaacagt ccagggatat ttgtcatttg atcgtaatcc acccataaac cgcccataga 2493601 ataatggacc gccgggaaga ttttcattgg aagcttacgc gggtcgtctc ccatgaattt 2493661 ctcataaatc tcaatgatgc cgccaagctt aatatcaagc tctttcggat ctttatgaga 2493721 cagatcgaga tataccatgt tttcaccgtt aataccgagc ttctggttca cacacacatc 2493781 aaatatttcg cgtgtcgcaa tatcacgcgg caccaggttt ccgtatgccg gatatttttc 2493841 ctccaggaaa taccatggtt tgccgtcttt atatgtccac acgcgcccgc cttcaccacg 2493901 cgctgattca ctcatcagtc ttagtttgtc atcgcccggt atggctgtcg ggtggatttg 2493961 aatgaattct ccgtttgcat aatacgctcc ctgctgataa acgattgacg cagcagatcc 2494021 tgtattaatc atggagttcg ttgattttcc aaagatgatt cccggtccgc ccgtcgccat 2494081 aatgacagcg tctgaacgga aggattcaat ttgcatgttt gtcaggtttt gtgcaacaat 2494141 tccgcggcag gttctgtcat catctaaaac agcgccaagg aattcccagc cttcgtattt 2494201 tgtgaccaga cccgcaactt cgtatctgcg cacttgctcg tccagtgcgt aaagcagctg 2494261 ctgtcccgtc gtcgcaccag cataagcagt tctgtggtgc tgtgtacccc cgaatcggcg 2494321 gaaatcaagc aggccttcag gcgtccggtt aaacatgacg cccatccggt ctaataagtg 2494381 gatgatcgaa ggcgccgctt cacacatcgc cttgaccggc ggctggttgg caagaaagtc 2494441 tcccccgtat accgtgtcat caaaatgttc ccacggagag tcaccttccc cttttgtatt 2494501 gaccgctccg tttatgccgc cttgcgcaca aactgaatga gaacgtttga caggaacgat 2494561 ggaaaacaat ttaaccgcca ttcctgattc cgctgcttta attgtcgcca tgaggccggc 2494621 aagacccccg ccgactacga taatgcttga ttgactcatg atagcccctc tccctctagt 2494681 aatctagtac tcttaaacaa atgcaaaaat cgcttttaag cctacgtatg acagtgcaac 2494741 aaaaataatc agcgtaacgt atgtcgaaat tctttgagaa cgaggcgtta ccgtgatgcc 2494801 ccatgtaaca gcgaaagacc ataaaccgtt cgagaagtgg aaaattgttg ataaaacacc 2494861 gacaatgtaa aaaccaagca tagccggaga gctcaaaata ttcgccatca tgtcgaaatt 2494921 gacctcagca cccatttgtg cggcaatgcg ggtttcccac acgtgccagc tgacgaaaat 2494981 gagggtgatg ataccggtta cacgctgcag gacgaatagc cagtttctca tgtagctgta 2495041 ttgaccggcg ttatttttcg cagtaaacgc tatgtacaca ccataaactg catgataaat 2495101 taatggtaag aagataataa aaatttccaa ggcatacctg aaaggcaggc tatccataaa 2495161 atgagcagcg ctattgaatg cttcagcgcc ccttgcggca aactggttga cgactaaatg 2495221 ctgaataaga aagatgccga ccggtatgac gccaagcaag gaatgcaatc ttcgaaaata 2495281 aaactctctg ttcccagaca ttactttacc ccctgtttga taagtgcgaa atgtgctaaa 2495341 tctcttcccc cacttctttc aattgtaagc actttattaa gatttattga caatttcatt 2495401 ttactcctcc ctcaaaaggg cgtcaagaaa acgcgtacat aaattataat tttccgaatt 2495461 gattagttga ttgaaaaatt ttattttatc aatatatatt tcttgcttaa tttttcataa 2495521 gaattacagg atcattctgt aatcctcccc cctgtttgag ctataatata cgcaggagag 2495581 aggggagaca gatatgaagt ctaaatttga agcatctatt gacaacctaa aagaaattga 2495641 aatgaacgct tatgcctacg aactaatacg agagatcgtt ctcccagata tgcttggcca 2495701 agattactct tccatgatgt attgggcagg aaaacatctc gcccgtaagt ttcctcttga 2495761 atcatgggag gaatttccgg ccttctttga agaagcgggc tggggaaccc tcaccaacgt 2495821 aagcgctaaa aaacaggagc ttgaatttga acttgaaggg ccgatcattt ccaaccggct 2495881 taagcatcag aaagaacctt gctttcagct ggaggctggt tttatcgctg aacaaattca 2495941 attgatgaat gatcagattg ccgaatcata tgaacaagtg aaaaagagag ccgataaagt 2496001 ggttctgact gtgaaatggg atatgaaaga cccagtgtaa tcaaaaaggc ggtgactgca 2496061 tagtcccgcc tttttgattg tcattacaca gctgaagggt gttttgaaag ctcaaatgca 2496121 tcgtgaagcg actcgactgc tttcaccatg tcattttcgc ttacgactgt tgacactttg 2496181 atttcagatg tgctgaccat tttgattaaa atgttttttt gcgccagtac agcaaacatt 2496241 tcagccgcta caccgggatt tgagaccatg ccggatccaa caatagatac tttagccaat 2496301 ttgctttctg tctcgatttt ctcaaattcc agcgcgtctt tatactcttc aagcaccgca 2496361 acggtttggt ctgcatcttc tgttttgaca gagaaggaaa ttccagtctt gtcctcggcc 2496421 tgcgtttgga taatgatatc cacgtttatg tttcttttgg caagtgttgt aaaaatagta 2496481 gacaaagttg tcaggccgct agtcagcccg taaatggtta ctcttgtgat ttgatcttca 2496541 aatgcaatgc ctctgacaat taaattctgt tccatggatg attcctcctc aattaatgtt 2496601 cccgcttcgg tttctgtact tgaacgcact tctaacggca cttggtaatt tttcgcgaac 2496661 tcaactgctc tcggatgaag aacaccggcg cctaaattgg caagctcaag catttcatcg 2496721 tatgagatgc cctcaagttt tctcgctgat ttcacatagc gcggatcggt tgtaaacacg 2496781 cctggcacgt ctgtgtatat gtcacattta tcagctttta aagcggcagc caaagcaact 2496841 gctgttgtat ctgaaccgcc ccggcccaat gtcgtaattt cacaatcctc tgtcatgcct 2496901 tggaatcctg caacaatgac aatttttcct ttttcaagct ggtctgctaa aaccgaagtg 2496961 tcgatatctg taattctggc gtttccgtga atggcctccg tacggattcc cgcctgccag 2497021 ccagtataag acacagcgtc atagcctttt tcctgcaatg ccattgaaag gagtgaaatc 2497081 gtgacctgct cgcctgtcgc cagcagcata tccatttcgc gtttgctcgg ctggtcagaa 2497141 atagcttttg caaggctgac caattcgtca gtggattttc ccattgctga aacgacgaca 2497201 acgacttgat ggcctttctg tttttctgca attgcgcggt ttgccgcatt ttgaattttt 2497261 tcgactgagc cgacggaagt gcctccgaat ttttgtacaa taagacccat gtattaccac 2497321 cctttacatt ttggttcgtg cgggtgagga gaaagagcgc tttgtccaca ataaaaaaag 2497381 caatgagagg aatactctca ttgcttatca attaatcatc ataaatgatt atgaacaacg 2497441 agatagccct ccaagaaaat gatttcttga cagccttaca tttattcaat gcacggccag 2497501 caaataatac cgatggggtt ttatttgctt cggcgacgct cccctttcag cctttttcac 2497561 agaatccatc tttctccaaa ggcatactct tgaagttcgc acctctatct tcaccatata 2497621 acacgatcta actatgaaat tagttcacat tttatcagat cttatttaaa aggacaacat 2497681 tatttttgca atttgtcgta aaggagctga gccgccgctg cgggaacacc ggcttttttg 2497741 atgtcctcaa ggcttgcttc cttcattttt ttaacggaac cgaaatgctt taacagcatt 2497801 ttctttcttt tctctccgat acccgggatg tcgtccaaaa cggattgaaa cgcgcttttt 2497861 ccccggattt gcctgtgaaa actgattgca aaacggtgca cctcgtcctg aatgcgctgc 2497921 aggaggtaaa attcctggct gtttcgttcc agatacgcca cctccagcgg atcaccgatc 2497981 agtaaatttg aggttctgtg tttttcatct ttcgctaaac cggcgatcgg gatatccaag 2498041 ccgagttcat tttcaatgac atcccttgct gcgttgatct gcccttttcc tccgtcaatg 2498101 ataatcagat cgggcagcgg cagattctca cgaagcactc tcgtatagcg tcttctgaca 2498161 acctctctca tagaaccgta atcatccggc cctgtaacag ttttgatttt atatttgcgg 2498221 tattcctttt tgtatggttt gccatcgata aacacaatca tcgcggaaac cgggtttgtc 2498281 ccctgtatat ttgagttatc aaacgcttca attctgtgcg gcgtataaat atttaatgcc 2498341 tcacctagtt tctgcactgc cccgattgaa cgctcctcgt cccgttcgat taaagagaat 2498401 ttttctttca atgcgatttt cgcattttta tgggcaagca tgagcagttc ttttttcggg 2498461 ccttttttcg gctggtgaac gtttgtttcc agtagctgct cgatcataga ttgatctatg 2498521 ctgtccggaa ctaaaatctc cttcggaagg aagtggttgt tttttgaata gaactgcccg 2498581 atgaacgtga ggaactcttc atctgcttcc tgataaagcg ggaacatgct gacatcgcgt 2498641 tcaatgagct ttccttggcg gatgaaaaag acctgcacgc acatccagcc cttatcgtac 2498701 gcgtacgcga acacatcacg gtcgactaga tcgttcatcg tcattttttg tttttccatc 2498761 gttgattcaa tatgggcaat ttggtcacga agctcttttg ctcgttcaaa ctcaagattc 2498821 tcagcagctt catgcatttt ctcttcaagc tcttttttga cctcattata gccgcccctt 2498881 aagaaacgtg taatgctttc aaccagctct ctgttcgtct cttcggaaat atcctttaca 2498941 cacggagcaa ggcattggcc cagatgatag taaaggcaca ctctgtccgg gagcttggag 2499001 cattttctga gaggatacag acggtcgagc agtttttttg tttcccttgc tgcctgtaca 2499061 ttcggatacg gcccgaaata gcgccctttg tcttttttga cattgcgggt gacaatcagc 2499121 cttgggtggc gttcatgggt gagttttatg aaaggatagg ttttgtcgtc tttgagcatg 2499181 acgttgtatt tcggatcatg ctttttgatc agattcattt ctaaaataag cgcttcaaga 2499241 ttggaggacg tcacaatata ttcaaaatcc tcgatttccg tcacaagcct ttgggttttc 2499301 gcgtcgtgag aaccggtgaa gtaggagcgc actctgtttt tcagcacttt tgctttccct 2499361 acgtagatca cagtctgctg ccggtccttc atgagataac aacccggttg atcaggaagg 2499421 agggcgagtt tttctttcag ttgtttgttc atatgttacc cttccttatg tttaatcctt 2499481 tatttccagt ttaacacgaa cgtttgtttt tctctatggt tcacaattgg cgaataaaaa 2499541 aagcgatccc tcaatcggaa tcgctctggc atgtaagcag cggaaaatta aagatgtttg 2499601 tttacaagct cttgaagcgc ttcttttggt ttgaagccga ctgaagtttc aactacttcg 2499661 ccgtctttta acacaagaag agtcgggatg ctcataacgc cgtattttcc ggcagtttct 2499721 tggttttcgt ctacatcgat ttttacgatt ttcagtttgt ctcccatttc ttgatccaat 2499781 tcttcaagaa caggtgcaat cattttacaa ggtccgcacc aaggagccca gaagtctgcc 2499841 agtacgacgc cttcgcttgt ttcagctgag aaagattgat cagttgcttt tacgatagcc 2499901 attattgaat tcctccaatg tgaaatgatg atttttagta tagcatctcc cattcgttca 2499961 cgctatttta atgcttacaa attatttttt cctgatcaca gccggtttac tcatttttat 2500021 atggttgaat gggatatgct ctttttttaa aacacaaatc tgataatggc cccgatcact 2500081 acaattgccc caataatcat taaaatggta cgaagcataa gatcacatct cctcttcact 2500141 gtcatgtact ttaccatgcc ctgccggagc tgttttaaaa cctgaaaaag agcgccggca 2500201 tgaagctccg gcgctcttgc gcgattaaga atcagcacgc agcgtaagta agacgactga 2500261 cattggcggg agttttactt tcagtttgtt tttgctgagc gtgtattgtc tgaaggattc 2500321 cggtttgaca tgatgaggat cgtcaaacgt gttatgcgca ttcatttttt ctgccgtaag 2500381 aatgactccg gaatggtccg ctgccttgtg taggcccctc agctcgattt ccgcctctgc 2500441 tttgttttgg tgatcgatgt tgcaaattgt gatattgata tcgccttcag cttgtttcga 2500501 cgctgaaatg ctgatttgcg gaagcgtttc accgttccat tcatagtcgg cagacattgt 2500561 ctctgtggct aaaagagaag cgtcctggtg caccttaaac atattgaata catggtacgt 2500621 cggtgtcaaa agcatccgct ctccctcagt caaaatcatc gcttgaagaa catttactgt 2500681 ttgggcgatg ttggccattt gcacccggcg gcaatgctga tggaaaatgt ggaaatgaga 2500741 agccgccacc agtgcatcac gaatggtgtt ttgctgatat aagaaaccgg gattcgtgcc 2500801 tggctcggga tcaaaccacg tgccccattc atcaataatc agcccgaccc gctgctccgg 2500861 atcgtaccgg tccataatcg tgccgtgttt ttgaatcaat tcatcgatgt atttggcttt 2500921 tttcatcgta ataaaccatt catcttccgt gaattctgtg gctgatcctt tgcccttcca 2500981 gaaatccccc ggaatcgtgt aataatgaag actcaacccg tccatcaggc cagcggcttt 2501041 tttcataagc acgtccgtcc aattaaaatc atccacattt gcgccgcctg caattttata 2501101 aatgtcattc ccgctgtaat tgcggacata agtctgaaaa cgccggtaca gatctgcgta 2501161 gtattcggga tgcatgttgc cgccgcagcc ccagttttca ttgcccacgc cgaaatattt 2501221 cagcttccaa ggctcttctc ttccattttg ctttctccag tctgacatcg gcgtgccttc 2501281 ttcaaatgtc atatactcaa tccactccga catttcctga acggttccgc ttccgacatt 2501341 gccgcaaata tatggctcgc attcaagcag ctcgcaaagc atcataaatt catgcgttcc 2501401 gaattcattt gattcaattg taccgcccca gtgagtgttc agcattgtct tacggtcacc 2501461 gacaccgttt gcccaatggt attcgtccgc aaaacacccg cccggccacc taaggacagg 2501521 aatgtgcagc tgtttgagcg cctccagcac gtcctttcgt atcccgttga tattggggat 2501581 gtctgagtcc gttccgaccc agatcccctc ataaatccct cttcctaaat gctcagcaaa 2501641 atgaccgtat atatttttgt taatggttcc ttttgcgata tctgtttgaa tcactgcttg 2501701 atgttcagac atgcctctga tcattccttt catacggata tgaaaagcac cacagtcaaa 2501761 tatgtgatct gtcgtttgcc tgaggagtca gcatgaatgt aagcgctttt aaagtaacca 2501821 tattatatat gttcgtacat gtcaacgaca ttttctattg tttttatatt tgtacgtatg 2501881 tatttataaa tatgaaaaaa cccggacttt taaagtccgg gatttccttt atgagtgtat 2501941 attcagctgt ttgaattcct cagttaataa cgggacaact tcaaataaat caccgacgat 2502001 gccgtaatcc gctattttaa agatatcggc ttcggggtct ttattgatgg cgacgatcac 2502061 cttgctgttt gacatgccgg ccaaatgctg gatggcgccg gaaatgccgc atgcaatgta 2502121 caaatccgga gtaacgactt tcccggtctg cccgatttgg agagcataat cgcaataatc 2502181 agcgtcacat gccccgcgag aagccccgac tgcggcccct agcacctctg caagctcctg 2502241 cagcggctga aatccttcct tgcttttgac tcctcggccg cccgcaacga taattttcgc 2502301 ttcggagaga tcaacaccgt ccgccgtttt tttcacgacc tcttggataa cagtgcggag 2502361 gtcagtaaga gaaacatcaa tgctttcgat gctccccgat ctgctggtgt ctttttctga 2502421 agcttgaatg ttattggggc gaattgttgc aaagatcatc ggatcggttg aaatgacgcg 2502481 ttcaaaagct ttccccgagt aaatcggccg tgtgaacaca acattccctc cggtaacgct 2502541 tacatctata gcatcagaaa ttaagcctgt ttgcagacgg gcagcaagct tcggtgaaag 2502601 atccttgccc attgccgtat gcccgaagat gactgaatca ggattttctt gctcgataac 2502661 acctctcatg acctggctgt acccgtctgc cgtgtatgtt ttcagcttcg ggtcctcagc 2502721 ggtaagaact ttatctgctc cgtaatgaat aagctcttgt gcaatgcttt gtacattttc 2502781 accgatgaga acaccgatga cttccccatc tcctgaaatg gttcttcctg cagctattgc 2502841 ttcaaaggtg acatttcgca attccccatc gcgtatttct ccaagcacga tcactttttt 2502901 tcccattcta acatccccct gtttctttga atgtccaagt tttaaatgac tttagcttcg 2502961 ctgcggagca atgaaacaag ctcttttgcc tgttcagcag gctcaccttg gagaagcttc 2503021 ccggcttctt ttttcggcgg cagaaaacgt tcaatggttt tcagctttgg ttcagcatcc 2503081 tcttcgtcca gatcaagatc atcaagttca agctcttcaa gcggcttttt cttagccttc 2503141 ataattcccg gaagcgatgg atagcgcggc tcgtttaagc cctgctgagc tgtgacaagc 2503201 aatgggagcg tcgttttgat tttttcaaca tccccttcga cgtccctttc tgcttctgca 2503261 tcagtgccgt tgatttcgag tttggtgatc gtagtgatac acggaatgtc cagtagctcg 2503321 gcaagccgag gcgccacttg tcctgatcct ccgtcaatgg caacatttcc gccgagaatc 2503381 aaatcaaact cctgatcctt catatagtgg tataaaactt gagaaatgga atattggtcg 2503441 ggttcatcaa gatcatcttc tatgttgatt aaaacagctt ggtcacaacc catggcaagc 2503501 gccgtacgca attctttctc cgcttcttca ccgccgaccg tgacagcggt gatcgtgccg 2503561 ccatgctttt ccttcagctg gatggcttct tctatcgcgt actcatcata tggattaatg 2503621 atccattccg ctccgtcatc ctgaatcttt cctgtttcaa tgacgatttt ttcttctgtg 2503681 tcaaacgtcc gtttcatcag tacaaataga ttcatgatca tatccccttt tattcgcctt 2503741 tgaactgagg ctttcttttt tcgagaaatg cctggatgcc ttccttggcg tcctctgact 2503801 caaatgcttc cccaaatcgc tttgcttcaa gctttaagct gccttcatag gaatacacct 2503861 tgttggaata aagaagttca agcaaagatg ccagcgtttg cgggcttttc tctgcaaact 2503921 tagcggcaag tgcttttgct ttttcaatca cttctgcctc atctttcgct ccaattgaga 2503981 caagtccgag atcaagcgct tcttttccgg atatcggttc tcctgatccg atgagctcca 2504041 gtgctttggc tgtaccgaca tatctcggaa ggcgctgtgt ccccgcaaaa cctggaatga 2504101 taccgagatt aagctccggg agccccagct tagcatcttc tgccgcgatt ctgatgtgac 2504161 aggccattgc aagctccagc ccgcctccga gagcagcgcc gtgaatcgct gcgataatcg 2504221 gttttggaaa actttcgatt ctctccatta actgctggcc gcgctcagcg agcaatgagg 2504281 aatcctcatt gcctttaagc gatgtaaatt ctttaatatc agcgccggct gagaaaaatc 2504341 ttccctcgcc gtgaatgata atgcttcgta cgcctgcatc tgtctcacat tgatcaagac 2504401 aggaagacag ctcttctaat atccggcttg aaagcgcgtt tgccggcgga ttgtgaatcg 2504461 tcaagactgc cacaaattga tcaaccgcaa gtgaaattgc attcatagga cagaactcct 2504521 ttacttattg tgaattccgg ataccaataa ttctaaaacg ctgtttgaaa gcgcaacgag 2504581 atcgtacttt tggtcattca tcacccaagt tgtcacagtt tcgtcaatcg ttccaaaaat 2504641 catctgccgg gcgaggcgga catcgaggcc ttcttttatt tcgcctgatt gtataccttc 2504701 cgtcaaaatg ccatccaaaa tatttaagta gccttttaat atttcgttga ttttttggcg 2504761 cagctccaag ttggattggc ggagctcaag ctgcgtgaca atggcgagat tatggtcacc 2504821 cgctaaaagg gaaaaatgct ttgaaatcac aagcgccaat ttctctttcg ctgttgcttt 2504881 ttctttaatg tcctcttcca tccgctcaat aaattgaccc attttttctt tgaaaagaga 2504941 aattaaaata tcttctttgt ttttaaaata gagatagatg gtgccgtccg ctaccccggc 2505001 ttgtttggca attttggata cctgtgactg gtggtagccg ttttctgcaa tgacttctac 2505061 tgctgcatca ataatctgca tatactttgg ccgtttttgc ttcaatgttc atcgttcctt 2505121 cctatagaaa tgaatgacta ttcattcata atttcatgat aagaaggatt ttcaggtttg 2505181 tcaagtttat tcataggcgt tctctttttt tatttgatat gatgattttc ggtttcttct 2505241 tcaagtaaac gccttcttaa aatttttccc accgccgttt tcggcagctc ctttctgaac 2505301 tcataggctt tgggcacctt atagggagct agacgtgatc tcgcaaaagc gtccagttct 2505361 tctgtatcgg cttttgcgcc tttctttaat acgacaaatg cttttactgt ttctcccctg 2505421 taggaatcgg gaacgcctgc gacaacaatt tcctggatgg cttcatgttc ataaagcgct 2505481 tcttctacct cacgcgggta aatattgtaa ccgccggcaa tgatgatatc cttcttcctg 2505541 tcagcaatat agaaaaagcc ttcttcatcc atatagccca tgtccccggt gaacagccag 2505601 ccatctctca gcactgcggc ggtttcctct ggtttattcc agtatccttt catgacttgc 2505661 ggacctttta caatgatttc tccatgctca tacggagcgg caagctcacc cgtctcttca 2505721 gaatagatcg cagcgtccgt actcggccaa ggacagccga tactgcccgg cttgtttttt 2505781 ccccagataa agttggcgtg cgtcactggg gatgcctcag acaaaccata gccttccaca 2505841 agctttccac cagtcacctt ttcaaatttc tgctttacct ccacggggag cgcggctgat 2505901 ccgctaagac agcttttaat ggatgacaga tcataatgct gcaattcagg gtgatgcaaa 2505961 aggccaatgt aaattgtcgg tgcgccagga aagagcgtcg gtttgtgttt gtcgatgatt 2506021 ttaagtgttt cgagcggatc aaacttagga agaagaatca tttcgaagcc tagtttaatc 2506081 gaatagttca tgactgccgt cagtccgtag acatgaaaaa atggaacgat gcccagcact 2506141 ttttcagcgc cttctttcac gtcatacatc caagcggcgc acatttcagt atttgccaaa 2506201 atattttggt gcgtgagcat gacccctttt ggagctccgg ttgttcctcc ggtatactgg 2506261 aggacagcga tatcatgctc aggatcgatc ttcgggattg tcaggagttc agttttttcc 2506321 tgcttcatac aggaagcgaa cgtgtgaatg ttagctgttt tgtcaaagtc gatatgcact 2506381 ttttgttttt gcgtcagcgg gtaaagaata tttttcggaa aaggcaaata gtcttttaca 2506441 ctggttatca aaatctggtc gactattgat aacgttttca tttttattgc cttcgggaaa 2506501 agcaaatcta aggtgatgat tacacttacc tgagcatctc taagctggta ttcaagctca 2506561 tgctcggtat aaagcggatt cgtctgcacc acgatgccac cggcaaacaa gacgccataa 2506621 taagaaatca ctgtttgcgg gcaattgggc agcataacag ccactctgtc tcctttttgc 2506681 aggccattgc actgcaaaaa agctgcaagt ttaagagcat ccgtcagaat gtcatgaaag 2506741 gtgagttttt ttccataaaa cgatattgcg gttttatcag ggaatcgtgc ggcggagtct 2506801 gtcaggatgg attgcagggt tttattcggc aacggaagct catgcgggat atcgttggga 2506861 tactcggcaa gccacggctt ttgagactgc ataaaacctc ccctttcgat tttagagatc 2506921 caccttatca ttatagcaga tggacggcaa aaaaaagaaa aagaaaggta aatctttctt 2506981 tttctcataa tatgaacaga tatataagac caattaacaa aaagattccc gctgcggcga 2507041 gcagtatttt cgcaagcttt tccatctatt ctccgtcccc ttatattccg gctgccacca 2507101 caaaagaaag cccgacagaa atgacaaatg aaataaagcc gacagcccgg ttatcatttt 2507161 cgatttcctg atcaatttta aaccgcggag tcaaaaactc aaaaataaag tagctgatca 2507221 gaagcataac aaacccgtaa acgccccagc cgatcatttg cagcagcgaa ttatgctggg 2507281 agatggaatg ctgaaatacg tttgcgattc ccaaaatttt tccgccggtc gccattgcca 2507341 ccgcaagatt tcctttttga atctcttccc agtttttata agccgtcacc agctcaaaca 2507401 cagtcaaaaa gaggacgagg cagagaaccg cgacactgta atatgccgcg atttccacaa 2507461 gctcgttttc ccaaaaatca ctcatggcca tactcccttt tattttagtt caacaaccgt 2507521 aacgcctgat cctccctcac ctgcttcacc gaaacgggaa cttttgacgc tgcggtggtt 2507581 tttcagaaga tcctgtacgc cttttcttaa agcgccggtt ccttttccgt ggatgattga 2507641 cactcttgga tatccggcta acaccgcatc atccaagtat ttttcaaccc ggctgagggc 2507701 attttcatag cgttcgccgc gaagatcaag ttcaagcgat acgtgatagt cctttccttt 2507761 gaccgctgta atcatttttt ctttttttgg ctccggagct gatttgataa actccagatc 2507821 tttttctttt actttcatct ttaaaatacc gatttgaacg ttccattcat tgccgcctgt 2507881 tttttcgagc aatgttcctt tttgcccgaa agtgaggact ttcacctcgt cgccaggctt 2507941 aaagtcgcgt ttttgcgttt tcggcttttc cggtttcttg gacttttcaa aagcaggcat 2508001 agcgccttct aaccgtttct tcgcgttaat cagctcgtga tccttgaagg atttgtgttc 2508061 ttcttttatg gtgcgcaatt catgaataat gtcctcggct tctttcattg ccgcttttac 2508121 tttttcagca gcctgctgtt ctgcctcttc aagcattttg tcttttttgc tgttaagctc 2508181 gatgatttgc tgctgcagct ctttatgcag tttttccgct tcttttctga ttgattctgt 2508241 ctcagaaagc tcttcttccg cacgtttttt gctttgttcc agcgacgcaa tcatcgtatc 2508301 gacttcgtta tgctcggccg tcatttctga cttcgcctgc ccgatgatat ggtccgggag 2508361 cccgaggcgt tttgaaattt cgaaagcatt gcttcgaccc ggcacaccaa ttaaaagttt 2508421 ataggtcggt gacagcgttt cgatgtcaaa ttcaacgctg gcattcatga cgccttctct 2508481 gttatagccg tacgccttca attccggata atgcgtcgta gctaacactc gtgcattggt 2508541 gcgatgcacg tcatccaaga tgctcatggc gagggccgcc ccctcctgcg gatctgtccc 2508601 tgcaccaagt tcatcgaaaa gcacaaggct gttttcattg acctgttcta aaatgccgac 2508661 aatattcacc atatgggatg agaacgtact taaactttgc tcaatcgact gttcatcacc 2508721 gatatcagcg aatacgtgct caaatactgc cgcttctgac ccttcatctg ccgggatatg 2508781 aagacctgac tgcgccatta aggttagcag gcctaacgtt ttaagggtga ctgttttccc 2508841 cccggtgttt ggccctgtga tgacaatggt tgaaaaatcg cggccaagct cgatgtcatt 2508901 ggcaacaacc tgatcaggcg gaagcaatgg atggcgggct tttttcaaac ggataaagcc 2508961 ggtgtcgttc ataatcggtt ttgtcgcttt aaccgctttt gcatatctag cttttgcaaa 2509021 aataaagtca agcgtctgca gcacttgcaa atctagaaat agctcctctg tatactctgc 2509081 cgttttctct gtcagcacac gcaaaatccg ttcaatttct tgcttttctt tcactttcgc 2509141 ctgctgaagg gaattgttca tatctacaat cgcctgcggt tcaatgaata gtgtcgcacc 2509201 agaggatgag gtgtcgtgca caattcctcc atagctggat ctgtactcct gtttgaccgg 2509261 gatcacaaag cggtcattcc gaatcgtaac aatcgtatca gacagcattt tcgatgcgga 2509321 agaggaacgc agcatcgact ctaaccggtc tctgactctt gattcgagtg ttctgagctg 2509381 tgtgcggatt cctcttaatg tttccgatgc atgatcaagc acttctccgt gatcatcaat 2509441 gcaggaatta atgtcccgct ctaaatcgga cagcgtgata agctgttcag catgctgatg 2509501 gatcagcgga atgtcgacac cgtcttcagc catttgcgtg ataaaatgtt tcatttgttt 2509561 aactgcataa agcaggcctg agatttcagt gaattcagaa ggactgagaa cgctgccgat 2509621 ttccgcccgt cttaacgctc ctctgatatc tacaaggccg ccaaatggcg cttggcctct 2509681 cagccggata atgtcagaag cttcgtctac ttcatccagc tgttttttga tttcgtctat 2509741 agaagcagaa ggcttaagct cgagaagcat ttcttttccg agcgatgaag cggcatgccc 2509801 aataacctgt tctttcactt tatgaaattc aagagctgat aatacttttt gctgcacgat 2509861 tgtgtgagcc tccttactta atcgttgcgc ttcagaaatg cctctacgtc tttaagcgac 2509921 cgggcattca gaacgttttt cgtttccgtc catcctttgc gcgcggcagt aacgccagtt 2509981 ttcatatcgt ctaacatctc aatattatgg gcatcagtat taatcaccaa tgtaacccct 2510041 tgttcgtttg ctttcattaa atgctctgtg cgcagatcaa ggcgcgcagg gttggcattg 2510101 agttcaagcg ccgtatttgt tttcctcgca agctcaatca gctgatcaat atcgatttcg 2510161 taaccggccc gtctgccgat aaggcgcccg gtcgggtgtg cgataatgtc aacatgcttg 2510221 tttgtcagtg ccgtctcaag ccgtttcata atcacgtgtt ccggctgatt aaaactggaa 2510281 tgaatcgatg caataacgat atccatttcc gcaagcacat cgtcatcata atcgagcgta 2510341 ccgtcaggca ggatatccat ctcaacgcct ttcaaaatac ggaagttttc aaactctgca 2510401 ttcagcgcgt caatttcttt tgcctgctgc ttaagtcttt ctgcagtaag cccgttggcg 2510461 acctttaaat attgtgagtg atcggtgatc gccatgtatt gatagccttt tttgatgcag 2510521 gcttcagcca tctctctgat cgaaaatgcg ccatcgctcc acgttgagtg catgtggaga 2510581 tcacctttga tttgcccgag ctctatcagt tcaatgctgt cgctgtaggt ttccacttcc 2510641 tgtccgcttt cacgaatttc cggcggaatc agcggcaggc cgaagtgcgc ataaaattca 2510701 cgttcactcg gaaatgtttt gatctctccg gtttcaactg tctcaacgcc gtattcactg 2510761 atccgctcgc cgcgttcttt ggcgatttgg cgcatcttaa tattgtgatc ctttgatccc 2510821 gtaaaatgat ggagtgttgt cggaaactgc tcttccgtca caagacggaa atcgacgctt 2510881 gtttcatatt caaaggaaag gatgacggac accttcgtat ctccgcttgc gatcacgctt 2510941 ttgatgtttg gcagctcaag aagctgctct cttacttcag ccggatgatc tgtagcaatg 2511001 atataatcca gatccttcac cgtttcccgc gctctgcgga gacttccggc acgagaaaat 2511061 ttgatgatat gcgtaaattg agaaagatgc tcctcaattt cccgcgcgat ccggagggcg 2511121 tagccgatcg ggaaccgttc aggctgtttt ccggcttccc cgagcgcctg taatattttt 2511181 tcttccgatt ttttgccgaa gcccgcaaga ccctggacct tttgctgctc acaggcttcc 2511241 ttcagagatt ctgcatcgtg tacgccgagc tctttataca gctttgcgat ttttttgccg 2511301 ccgagccccg gcagcttcaa taaaggcacg agtccttccg gcacttcttt ctgaagcgat 2511361 tcgagcgtgc ttgactttcc ttcatctata tactctttaa tgacgctgta cgttcctttt 2511421 ccaatgccgg acagcgacat catatcgtcc atttctgata agcttcggtc gtcctgttcc 2511481 agagctgccg ccgcttttcg gaaggcggat actttaaacg ggttgtcccc tttgagttcc 2511541 atatagactg caatggtttc aagcagccgg ataatatctt ttttatgcat atcataaccc 2511601 ccagacgttc acatatgttt ccatcatact tgaaaaaaac ttctccggac aagagaagtt 2511661 tttttatgcc ccgtactgtg tccacagctc ttgtaaaagc cctgacaagt acggtgtatg 2511721 gttaatgatc acatttgcga gagacgattg ccccatcatt tgctgcaacg cgtctaccgg 2511781 cagaacggat gcgacataca gcagcacaaa tgtaaataaa tagacttcta gaaaaccgag 2511841 aacggctccc agcatctggt tgatttgttt aatcaccgga atgccggcta caatactcag 2511901 gaacgagccg atgattctca gtaagatttt agcaatgata aataaaacga taaacgcaat 2511961 cgcattatag tacgctgctt ccaaattccc cgtaaaaaaa gaaagagccg gctgtcccgc 2512021 tgaaaaatcg ggtgcgggaa tccaatgtaa atgcggtgcc acgtttttat agaataaagc 2512081 cgcaaaggca attgataaaa taaagctcgt caagcggata aactgcagga taaaaccgcg 2512141 ttttaacccc agtaaagtcc ccatcaggag caagattaag atgatgatat ctagcatagt 2512201 tgttcaatcc ttttctttaa gctgacgctc cagtttttca catttctctt gtaatttgac 2512261 ataatcgtgc accacattta ccgctgtcag cactgcaagt ttatttatat caaggtatgg 2512321 atttttttca ttgatttctc tcattttatc atcaacaatt ccggcgacat acctcatatg 2512381 ggctctgctt tcttcaccga caatcgtgaa gtgctggccg taaatgtcaa cggttgtttt 2512441 tgtttttttg ccgtcagaca acgtttctcc tccattccgc gagaatccta gttcttatca 2512501 taacacgttt attaaatgaa tggaaagacg agcctcccgc tgttatgata cactggtata 2512561 tacagcgaaa agtgtaaaaa aaggagatta ttacgtgtcc cattcagtga taaaagtatc 2512621 gttgtctgct attgaccaaa tgaaaatgac gtacagcggt tcacttacag cctctgttcc 2512681 gcagggagcc gtttttcagg caaaaccgcc cggctgtacc attacagcat atcaatcagg 2512741 taaggtcttg tttcaaggaa aaaacgctgc ggcagaatcc gcgcgctggg gaacagcaga 2512801 gcctcaggaa aagaagaaaa cggccaaaaa gccggctgat ccccgctatg cccctccggc 2512861 agatatcgcc ggaatgtctg ttatcggttc tgacgaagtc ggaaccggag attactttgg 2512921 cccaatgacg gttgtatgcg cgtacgtcga caaaaccatg cttcctttaa tgaaggaact 2512981 cggtgttaag gattctaaag atttaaaaga tccgcaaatc atcgagattg cccgaaacct 2513041 gattaaaacc attccgtaca gcctgctggt gttaaagaat gaaaagtata acagcatgca 2513101 ggaaaaaggc atgagccaag ggaaaatgaa agctttgctg cacaatcagg cgatcacaca 2513161 tttattaaga aaattggatg gagtaaagcc tgaagccatt ttgattgacc aattcgctga 2513221 gccaggcgtc tacttcaatc atttaaaggg cagagacatt gtgaaggagc ggacctattt 2513281 tagcacaaaa gctgaaggta ttcacctggc tgtcgccgct gcttcaatca ttgcaagata 2513341 ttcattttta atggaaatgg ataaactatc acgcgcggca ggaatgacgc ttccaaaagg 2513401 ggccggtccg cacgtcgatg aagcggccgc caagctgatc ctcaaaaaag gggcatctgc 2513461 actcagaacc tttacaaaac tccatttcgc caatacgcaa aaagcgcagc gccttgctga 2513521 taaaaaacgt tcatagaaaa aagcttgcag atttctctgc aagctttttt atcagcctct 2513581 taaaacagct tgatatgtgt cttctaacgc tttcagcact ttgctgtgcg cctttgtcac 2513641 ttcttcttca gtcagtgttt gttcaggatt gacatactgg agtgagaaag cgactgactt 2513701 cttgccttcc tccatatgct ctccttcgta tacgtcaaat acggttacct ctttcagaag 2513761 cttgcccccg gcctctttaa tgacgctctc gagctgtccg cttgtgacgg ttttatctgt 2513821 tacaagagcg atatcacgtg tcacagacgg atattttgga atcgccgtgt aaacaagcgg 2513881 tgctgtttct gctgcgagca acgcatgaag atcgagctca aatacgtatg tttcctttat 2513941 atccagttct ttttccaatg aaggatggac ttggccgatg aagccgatca gagaaccatt 2514001 caataaaatg ttcgctgttc tgcccggatg cagctgtttg cgttcagact gtacaaattc 2514061 aatgctgtct aggacgttga gtttgtctaa cagcccttcc acaattcctt tgacaacaaa 2514121 gaaatcaact ggtttctttt caccctgcca tagctgcttg cgccataatc cggtaacagc 2514181 tcctgctacg cgttctgttt caacaggttt tgtgtcctct tccttcgtta ggaaaacgga 2514241 gccaacttcg tacagtgcaa ctgagtcagt ctgcctcgca agattgtaag aaacagaatc 2514301 aagcagattt ggaacaagac tgtgtctgag aatgcttctt tcttcactca ttggaagcgc 2514361 aagcacagta ttcagtgatt tttcaatcgc aaacgctgtc gctttcttct cgtttgtcag 2514421 tgagtaagtg atggcttgtg ataagcctgc gccttcaagg aagcgtctga ctttacggcg 2514481 ttttgcctga tatggcgtta atccgcctgt agttcccgct gtctcaggaa gcgtagacgg 2514541 aatgttatcg tagccgtaca gtcttgccgc ttcttcgatt aaatcctctt ctattgtaat 2514601 gtcaccgcgc cgtgatggga cagtcacaac gagaagatca tccgcttcac cgaccgtaaa 2514661 accgagacgt ttataaatgc tgatcagttc ttctttactg atcgtcaggc ctagaacgct 2514721 gctcactttg tcagcagata cgtgaatgtt atttgcttcg attgtcaggt gatcttcctc 2514781 aaccgttcca gcaagcacct caccgccggc atacagatgg atcagctgcg cagcccgttc 2514841 tgctgcaaga cgtacgcgtg ccggatcaat tcctttttca aatcttacgc ttgattcact 2514901 tctcaaacca aggtctttgg aagccttgcg aaccttctgc ccgttgaaat acgcagcctc 2514961 aagcaaaatg gttttcgtat cttcctgaac ctctgactct gctcctccca tgacaccggc 2515021 aacggcctgc gctttcgttc cgtttgtaat gacaaggtga tcggcagaca gcttacgttc 2515081 ttgatcatca agtgttacga tcatttcatt ctcagctgct tttcttacta cgacttcctt 2515141 agagccaaat ctgtcataat caaacgcatg aagcggctgt ccgtattcca acaggacaaa 2515201 atttgtgatg tcaacgacgt tgttgtgcgg acgaatgcct gcattcatca gctttgtctg 2515261 catccaaagc ggtgacggag caatcgtgac atttttaatg atttttgcag tgtacagcgg 2515321 gttcgcttct tgatcttcaa ttttgactga aatgtaatca gacgcttgtt ctgaagcagc 2515381 cgggtaatcc gtttgcggaa gctttacctc agtgtctaaa atcgccgcaa cctcgtaagc 2515441 aacaccaagc atgttcatgg catccgcgcg gtttggcgtt aaacccagct caagaatcgc 2515501 atcgtcaagc tgtaaagccg ctaaggcatc gcttcctgtt tcagcgtcat tcgggaatac 2515561 gaaaatgcct tctgcatact ccttcgccac aagtttgctt tcgataccaa gctcctgtaa 2515621 ggaacagatc atgccgtttg attcttcacc gcgaagcttg gcttttttga ttttgaaatt 2515681 gcccggcagc accgctccga ctgttgcaac tgcgactttt tgtcccttat ccacattcgg 2515741 cgcgccgcaa atgatttgta caggggcttc agctccgata tccacaaggc acttattcag 2515801 cttatcagca ttcgggtgct gctcgcgctc cagcacatgg ccgatgacaa cgcctttgat 2515861 gccttctcct ttgtattcaa ttccttcaac ctcaataccg gctcttgtaa ttttttcagc 2515921 aagaacagcc gggtccatgc cttttaaatc aacataatcc tctaaccatt tataagaaac 2515981 aaacatcctt gcatcctcct cttacgcctg tttaaactgc gaaataaatc tgacatcgtt 2516041 tgtatagaag tggcggatat catcaatgcc atatttcagc atcgcgatgc gctcaacacc 2516101 cattccgaat gcgaagccct gatattcctt cggatcaaag ccagccattt taagcacgtt 2516161 cgggtgaacc attccggcac cgaggatttc aatccagcct gttcctttac atactgagca 2516221 gccgttccca ccgcatttaa agcatgtcac atccacttct actgaaggct cagtaaacgg 2516281 gaagaagctt gggcggagtc tgatttcacg gtcttgcccg aacatttttt tcgcaacaag 2516341 ttcaagcgtt ccttttaaat cactcatgct gatgtttttg tcaacgacaa gcccttcaat 2516401 ttgcataaat tggtgagagt gcgtcgcatc atcgttatca cggcgatata ctttacccgg 2516461 gcaaatgatt ttaacgggac ctttgccttc atgcttttcc atcgtacgtg tttggacagg 2516521 agaagtttgc gttctcatca aagtttcctc tgtgatgtaa aagctgtcct gcatatcgcg 2516581 cgctgggtgt tctttcggaa gattgagcga ttcgaagttg tagtaatccg tttcaacctc 2516641 tggcccttcc tcgactgtgt agcccatacc gataaataaa tcttcaattt cttcaatgac 2516701 aacagtgagc ggatggcggc cgccgactgc aacagggttc cccggcagcg tgacgtcaat 2516761 tgtctgtcct gcaagcttct gtttcatttc ctcttcttca agcttctcgt ttttgtcagc 2516821 aatcgcattg gcaatacgct cccttacttc gttcgcgagc gcccccattt ttggacgttc 2516881 ctcagcagaa agcttgccca ttccgcgcag cacttctgta atcggccctt tttttccgag 2516941 atattgcacc cgaatatcat tgacaacctt caatgagctt gccgcttcta cttgttctaa 2517001 agcttcttgt tccagctgtt ttagcttttc ttccattttg catcctcctt ttatgtaaac 2517061 aaaccgtcat atgtctttgg aaaataaaaa aaacccgtcc cttgtacaag ggacgagttg 2517121 tggccgcggt accaccctta tttcagacag actgatgctg tcgtcagctt cattgacata 2517181 acggaatcag attccggttc acctttacgc gcagtgtacg cggtcccggc gacaactcaa 2517241 gaggtgaagc caatttccgg ctgcgttaaa aatgctctca gtcagcggca ttttctccct 2517301 ggaaagcagt tgatcagaaa ttgaggtcct ctgtcacggt ttttgaaata ttatgttcta 2517361 ttatagagaa atccaacgct tggcgcaaca ctatcctcgc aagtgataca cgaggatggc 2517421 agccgcaacc gcaacgttta gtgattcagc ctgtccgtaa agcggcacgt acaggttcaa 2517481 atccgttttt tccagcaatg cagcatctac ccctgcacct tcatttccta caatgagcgc 2517541 aaaggattca gactgaggaa tctcctggta aggcgctccg ttttgcagcg ccgtgccgta 2517601 tacttttacg ccctctgcct tcaattcgtc cacatatgaa ggcaggtttc ttctcacaac 2517661 aggaatatgg aagtgagatc cttgagcaga tcgcagtgtt tttccgttaa aggcgtccgc 2517721 cgtgccgtca ccgagtacaa ccgcatccaa accggccgca tcagccgttc gaatcattgt 2517781 gccaaggttt cccggatctt gaacagcgtc aatcagcagc accttgcgtg ccgttgccag 2517841 cttttcttca ggcatatggc acacagcggc aatctgctgc ggcgtttcgg tttcagtcac 2517901 agctgaaaac gcatcttcac tcagcatata gcactggata ccagtctcaa gatctgaagg 2517961 aatcctcgtt tcatccttta caaggatttc tttcacaatg cccgggcttt tcaacgcctc 2518021 ttcaacgagg tgttctccct ctatcagaaa tgtatttgtt tttgttcgtt ctttttttgt 2518081 gtgaagcttt ttccaatcct tcactttttg gttttttgcc gattctattt gtttcactgt 2518141 ctatgtggcg ctcctttttt taacatgatg ttattatatc gcaagaacag cacataataa 2518201 accaggtgca gggttagaat atacgtatta cattttagaa aaaggagcgt tttacatgga 2518261 tcttaattta cgtcatgccg tcattgccaa tgtcaccggc aataatcagg agcagcttga 2518321 gcatacaatc gtagatgcga ttcaaagcgg tgaagaaaaa atgcttccag ggctcggcgt 2518381 tttattcgaa gtcatttggc agcacgcatc cgaaagtgag aaaaacgaaa tgctgaaaac 2518441 gcttgaaggc ggattaaaac ccgccgaata agacatgaaa ccgggtgaca gcgcccggtt 2518501 tttttcttat ataataaaaa catgatgagg gggaacgcca tgtttttaca gccgttatta 2518561 gcgaaaaaaa ttattgctga agttaaaaaa atgtacgaac gtgaagtcat tattgtaaac 2518621 acggacggtc ttattatggc aggcacaaac gatgagcgtg tcggacaatt tcatgaggga 2518681 gcgcttatct gcgcaaaaga aagacgcagc gtgattatta caaaagaaga tgaaacaagg 2518741 ttaaaaggag tgaaagcagg cataaacctc cctgtatttt ttgaccatga tgtgattgcc 2518801 gtcttcgggc tgacaggtga gcctgcagag attcagccat tcggagaact gcttcgaaaa 2518861 atgacagaac tgttcattaa ggaatcgcgg cacttagagc aatcccagtg gcgtgagaga 2518921 atgctggagt cctttatgat cgattggctg caattaaagg agtggtctcc cagttttctt 2518981 gagaaagctc agcttcttgg tgttgacctt tcttcccggc gccaaatgat tcttattcag 2519041 gggtatgagt ggtcacctca tgatattgaa caaatggcac gcagctggaa atcctcgtac 2519101 cctgcggatt tgttcatcag gtggggaaat gaacggattt tgattaatca tgaagtgccg 2519161 cagcatgaac aaagggatcg gcttttgcgg aaaatccttc acatttgttc gtttgccaat 2519221 accgcaagca gccaatatac agcagctggc gccggaaggg ctgtcgcaag ctccagcctg 2519281 acagattcat acgagcaagc ggaaaaagcg ctggctgtca gccttaagcg aaaaacgccc 2519341 atatttgaag aggatctgaa gcttgatatg tgtctgacgg agatcagccc gggaacccga 2519401 aacgaatttc cgcaaagagt attaggaaag gcgctagagc atcaggaact tatgaatacg 2519461 atacggactt tctttcatca cgatttgtct ttgaaacaaa ccgctgaaga catgcatata 2519521 cacatcaata cattgcgtta tcgtctggct aaggctgaac agctgacggg attacgtttt 2519581 gaccgtaccg aggacgtcgt cacgatgtac gtcgcactct attttttaga tcaagataca 2519641 aaatagagag agtttcagtt tcattttttg tatgtttctc catggaaggc tttgcttttt 2519701 ttcttttaca atagattgaa agcgtttttt gacaggggga tgggtgaaat gatcaccaag 2519761 gatgtaaagg agcagctgat tcaggtctcc ggaccagaaa actttgatga ctcgaatgcc 2519821 ggccgtctcg tctattcata tgatgcgacg cctcagtatc agtctatgcc tgatgccgtg 2519881 attgctccga ggaatactga tgaaatatca cgcattttaa caatttgcag cgaacatcga 2519941 gtgccgatcg ttccaagagg atcagggaca aacctgtgcg gcggcacgtg cccgactgaa 2520001 ggcggacttg tgcttctctt taagcacatg aaccagattc ttgaaattga tgaagaaaat 2520061 ttaactgcca cagttcagcc gggcgtcatt acgttggata tgatccgggc agttgaaagc 2520121 aaaggtttat tttatccgcc tgacccgagt tctatgaaaa tatcaactat cgggggcaac 2520181 atcaatgaaa attccggcgg gctacgcgga ttaaaatacg gtgtcacccg cgactatgtt 2520241 attggactgg aggttgttct cgcaaatggt gacatcatcc gcaccggcgg aaaactcgca 2520301 aaggatgtgg ccggatacga tctcacacgt ctttttgtcg gctcagaagg aacactcggc 2520361 attgtgacag aggcaatcgt caaactcgtt ccaaagccgg aaacaaagaa gacgctgctt 2520421 gccctttatg aaaacatcga tgccgctgct caaacggtat cggacattat tgccgcaaaa 2520481 attatacccg ctacgcttga atttctcgat cagcctacac tattggtgat tgaggattat 2520541 gccaaaatcg gacttccgac aagcgcaaaa gcagttctgt taattgaaca agacgggcca 2520601 tttgaaactg ttgaacggga tatggaaaag attgaggcga tctgcaaaaa aggcgacgcc 2520661 gtatccgttc agaccgcaca aacagaggag gaagcgtttg ccctgactga agcccggcgt 2520721 tctgcacttt ctgccctagc ccgcctcaaa ccgacgacga ttttagagga tgcgaccgtt 2520781 cctcgctcag aaatcgccaa tatggttaaa gcgattaatg atattgctgc taaatatgat 2520841 atttccatct gcacctttgg tcatgcggga gacgggaacc ttcacccgac atgcacgaca 2520901 gacataagaa ataaggatga aatggaacgt gtcgaacagg cttttgccga gatttttgag 2520961 aaagcgattg aacttggcgg gacgataacc ggagagcacg gagtcgggga aatgaaagcg 2521021 ccttacttgg aaatgaagct gaaaaaagaa ggcattgatg cgatgaaagc gttgaaagcg 2521081 gcatttgacc cccggaacat attaaatccc ggcaaaatgt ttgcgaaaga tgccagaaaa 2521141 cgtgtggtgg cggaaagatg acaacagaaa aagaaatgaa acagatccaa aatgaattta 2521201 aagagcgtat ggatgaagga gagttattaa attgtatgcg ctgcggcttc tgtcttcctt 2521261 cctgtccgac ctatatcgaa tcgggatttc aggaaacaca ctctccgcgt gggcgcatcg 2521321 ccttaatgaa agccgtagcc gacggtatga ttgaaccgga tgaagatgtc gaacggtcgc 2521381 tgtcactttg cctcggctgc cgcgcctgtg agcctgtatg cccgtctggc gtgaaatacg 2521441 ggcagctgct tgaggaagcc agagatatta tccaccaaaa taaaaaacac tctcttggtg 2521501 aacgtgtcat gcgaaagacg gcttttcacg agctgtttcc gcatcaaaac cgcatgcgct 2521561 cagctgtaag ccttatcggt ttgtatcagc gttcaggact gcaaaccgct gtgcgaaaat 2521621 caggcatgct tcgggtcctg cctgagcatt tgcggacgat ggaagctgtt cttcctgatg 2521681 ttccaaaaag caaagacatg aaacatcggc cgcgtttcct gccttccatt ggccccatga 2521741 aaaaacgggt cgcctttttt tcgggctgct taatggatac aatgttttta ccgaccaata 2521801 acgccacatt gaagctttta cagctggcag gctgcgacat tgtcattccg cctgaacagg 2521861 cttgctgcgg ggcgcttcat ggacacagcg gtgaaaaaaa cacagggaaa gagctcgcga 2521921 aacaaaatat cgctgctttc gaagcattag acgtggatgc agtcattaca aacgcaggag 2521981 gatgcggagc ctttctcact gaatatgatc atttgctgaa ggatgaccct gagtggtcgg 2522041 aacgggctgc cgcttttgtt caaaagctga aggatttttc ttctgttttg gttgaactcg 2522101 atttccatca aatggatcta gcactcgaga cgcctcaggt cgttacctac caagattcat 2522161 gtcatctaag aaatgtgatg catacgtcac ttgagccccg ccagcttctt aaaagcatca 2522221 aaggggcgga attcaaagaa atggagaaag cagacagctg ctgcgggtca gcgggaattt 2522281 acaacatcgt cgaagttgaa atgtctatga aaatactgga cagcaaaatg gctgccgtca 2522341 aagcaaccga agcgatcctc attgtaacag caaatcctgg ctgcctgctg cagatgaagc 2522401 tcggcattga acgcgaagga ctaagcggta aagtcagagc cgttcacctg gctgatttgc 2522461 tattagaagc agccgggcac aaaacatcat gagaaagccc aaaacagaca ttgttttggg 2522521 cttttgtgcg ttattccatc ggactgcaaa tttcgatata atgtccatcc ggatcagcga 2522581 tataggcgac cgtctgcccc catggtttca ctttcggctc cccgataatc gatacgcctt 2522641 gttctctcat ccttttgatg accgcttcta cattttcagt aacaaacccg atttcaaatg 2522701 tgtttgaagc agatgtatcc ggaatgtcca gcgccgtgat gtctctggcg ctttcccggg 2522761 tattaagcgc caatatcgta gaccctgtat caaattcgac atacgtgccg tgttcagcac 2522821 gaatcggcag tcctaaaata tcccggtaaa aaatgaatag cccgcttgct gtccgatacg 2522881 tatagaataa gatatttcat tgatagattc attgccaacc cctctcagca ttttcaatag 2522941 tccttctagc ccggtataga tgcttccatc cttaagctcg gatctttcca catctgcgcc 2523001 cattttttca cagccgccac gataatgatg aagcctaaca ccagcatgat gatagataat 2523061 acgccattca atacactata tcctgctgct tcaggattga gatacacatt gcgcaccatc 2523121 caatagcccg cataattgac agtgacatat aaataggcaa gcgggataag gcaagtcaga 2523181 atgtaccggc gtttatcggc gattttcagc acgatcgtcg ctccgataat cagccccact 2523241 gaagccatca gctgattaga aacgccgaag agcgcccaaa tggaaccgat atctcctgaa 2523301 tacagcaagt acccccacat caaacaggca agcgcgctgg caaatacaga gcccggaatc 2523361 cagtctgttt tcttcagcgg cttatacacc tccccgaaga agtcctggat caaataacgg 2523421 gcgacacgtg tgccggcgtc aatcgctgtt aaaataaaga ccgcttcaaa cataatgaca 2523481 aattggaaaa agtatgaggc caaatggctg aaaaacggca ttccggtaaa aatataagtc 2523541 atccctaccg caagcgtgac ggctccccct gttcttcctt ctaagtccaa accgatttcc 2523601 ccgctcaatt caggcaaatg tacgacattc atgccaagcg tacggaaaac ctcaggcgtg 2523661 ctgttaatcg caaagtaatc agcaggctgt aaagcggtcg ctgcaatcag cgccatgata 2523721 ccgacaagac actcaacaag cattgcgcca aacgcaaccg gcttcatatc actccattta 2523781 ttcagcattt tcggtgtcgt tcctgagccg acaaaggcat ggaacccaga gatcgccccg 2523841 caggcgatgg ttattgagat gaacggccag acaggtcctg ccagcaccgg ccctccgcct 2523901 tttacgaatt ctgtaaacgc agggaacgga atggacggat tgacgacaaa cacaccaaca 2523961 atcaaagcga taaaaacacc gattttcata aagctgctta aataatcacg cggagccaga 2524021 agcagccaaa cgggaagcgc agccgcaaaa aacgcataaa caggaagcgc gattgcaagc 2524081 gttttcgtat ctagcgttaa aaagtcaccg agcgcggtag tctgtaccca tggaccgata 2524141 aagactcctg ccattaaaaa gagaaagccg accgttgaag cgagctttaa atttcccgtt 2524201 ttcttataaa ataagcccac acccatcgca atcggaatcg taatccccac cgcaaatgtt 2524261 ccccatggat tacgttcaag cgcatgcaag acaaccatcg acaggcccgc cattgtgatc 2524321 gtgatgataa acagcatgga cagtcctgta caaaatcctg caacagggcc aagctcatcc 2524381 ttcgccactt ccgacagcga ttttccgttt ttgcgcatcg atgcaaacaa caccacaata 2524441 tcatggacgg ctcccccaat taccgccccg attaacagcc acaataatcc cggcaaatag 2524501 ccaaactgcg ccgccagaat tggtccgacc agcggcccgg ccgctgcgat cgcggcaaag 2524561 tggtggccga acgaaaccca tttatttgta ggcacatagt ctttcccatc ctcaagcgca 2524621 tgagcaggtg ttggcttgtc atcattcact ttgagaacct tcaccatcat aaatgttccg 2524681 tataaacgat aggcaatagc caaaatacac attgatgcta tcacaattgt aaccgcattc 2524741 attttctccc atcccctttt ctgtttttca taaatatatc ataatttcat ggtgaaaagc 2524801 ggtcattttt tcctatacaa aaagccggct ggaatgggcc ggctcgtggc agttgaaaga 2524861 caagccggag agaaatctcc ggctttgcta ttcttatgac tgttttttca ggcggatcac 2524921 attccaggaa agcggcgtga aatgagcagt taagccgttt tcgctgacag acgatgatcc 2524981 gttggaatgc ggaacgacat tttttctgtt atgctggttt gttgctttga tatcctgatg 2525041 ctcaagtacg atgtgctctg cgatttggta ggattcaaag cctctgagcg aaatctccgt 2525101 ctccatctga tcctcagcct tgtttaccgc aaaaatagtg agtgtttctt cctcttcaga 2525161 gtacacaaca gcagcatcaa catatggcac atcagtgaaa tcagaacaat cgtacttagg 2525221 agaagaaata agcggtttca gtgactcgcc ccttccgtaa acagaagcat gcatgtatgg 2525281 atagaaaatc ggctgtctcc atgcttctcc gcctttttcc gtcatgatcg gcgcgatgac 2525341 attaacaagc tgtgcaagac acgcaatttt cacacggtct gcgtgctgca gcatcgtaat 2525401 gagcagagag ccgactaata aggcatcttc aaaattgtaa atatcctcta aaatcggacg 2525461 cgcagtgatc cacggctcga cttttttatc agcctcattt gagtggtacc agacgttcca 2525521 ttcatccaga gagagattga tagttttctt gctgcgtgtt tttgctttta catagtcaca 2525581 ggtcgcagcg actgatttga taaaatgatc caaatccata gaacgtgcca agtagtttgg 2525641 cagattgtta tcccggtttc cgtagtaagt gtgaagagag atatagtcga catgctcata 2525701 cgtatgctca agcaccttcg cttcccaatc gataaaggtc ggcataccgc tgtttgagct 2525761 gccgcaggca acgagttcaa ttgatgggtc aacccacttc atgacctttg ctgtctctgc 2525821 ggcaagccgt ccgtattcat cagctgtttt gtggccgatc tgccatggtc catccatttc 2525881 gtttcctaag caccatgttt tgatgccata cggctgttca tagccatgcg atcttcttaa 2525941 atcactccag taagagcctt tcggatggtt gcaatattca acgagattac gggcggcatc 2526001 tatgcctctt gtgccaaggt tgacggccat attgacctca gtgttcacct tttttgccca 2526061 agataaaaat tcatttgttc ccacttcatt ggtttctgtc gtttgccatg ccaagtcaag 2526121 ccgtctcggg cggttttcga ctggtccgac accgtcctcc cagttgtatc cggataaaaa 2526181 gtttccgccc ggatagcgga tgatgggaac ctgtaattct ttgatcagcg actggacatc 2526241 ttttctaaat ccatcttcat ccgcttcagg gtgatcaggc tcgtatatgc cttcatatac 2526301 cgcacgaccc atatgttcga taaacgagcc ataaatccgt ttatctactt caccgatttt 2526361 atattctttg tctacaatca ttcgcgcttt tttcatcaca cgtttcctcc ttcattaacc 2526421 tttgactccc cctaccgtca ggccggagat aaagtacttt tggaaaaaca agaaaatgat 2526481 aatcaccggc aaaatcgcaa atactgagcc ggatataagc atgtcgtaat tatttccata 2526541 agggctcagc aagctggaca gccctattgg aagcgtaaac atttctttcg accgaagcac 2526601 aatcagcggc cacaagaagt tgttccagct gtttaaggac tgaaggataa tcatcgcacc 2526661 gaaagccggt ttcatcagcg gtgccataat cctgaaaaag atgccgaatt ccgtacagcc 2526721 gtccatcctt gcagagtcca gcagatctct tggaaggcca agagcatatt gcctgaaaaa 2526781 gaaaacagca acaggtgaaa cgataaacgg caatatgaca cccgtatatg aatcgatcaa 2526841 gtgcagtccg acagtaagtt taaacagagg aagcatcatc acttccagcg gaaccatcat 2526901 aataatcagc acaagaacaa agatgatatt tctgccctta aaatcataaa ccgcaagccc 2526961 gtacccgatc atcgaagaaa aaaacagagt gagcacagtc gtaaaaagtc cgagtacaag 2527021 actgttaaaa aaccatttga aataaatgct gccgccatta aacagaaatg tgtagttatc 2527081 aaaactcatc acttttggat caatatcaag attcagcccc acacgcaaaa gctcagatga 2527141 cggctttaat gatcctaaaa gcaaacagaa aatcggaaaa agatacaata ggctcagcat 2527201 cataaaaaac agggtcagcg caattctata aacgctaaac tgaggactgt gccgcaacat 2527261 ttatccctcc cccttaaacg agcctgacag ctttaatgaa atcaggctga caacaaggat 2527321 cacaatcaaa agcacaatgc cgatggccgc tccgtatccc atttcattgt aggcaagtcc 2527381 ctgctgatac aaatatccga caagcgtcag accaatatta cccggggaat tattctgcca 2527441 aaggacgtag ctttcctcaa acatcctgaa gccgccgatg atgctgatgg tcagcacata 2527501 tacggttaca ggcttgagaa acggcagcgt gatgtgcaga aattttttca ttgtattcgc 2527561 gccgtctata tcagcggctt cgtacagctc tttcggcaca ttttgcaaac ctgctaaaaa 2527621 gtaaaggatg ttgattccca tccatctcca tgaagcaagc agcaccatca aaaacatgcc 2527681 ggtatgttca ttgttcatcc agttctgagg tgaaaagccg agtttaagta ggatggaatt 2527741 ggccagagac gtttccattt ctccgaagat cagccgaaaa atgatccccg cgacaatggt 2527801 tgaggtcaat gccgggataa ataatgctga tttaaatata tttctaaatt tgaccagctt 2527861 tgaattcagg aatatggcca gaagcaatgg aacaggaatc agcacgatca gcgtccaaaa 2527921 ggtgtattcc agcgtattcc aaagggcggt atagaacgtc gggttgttta gcgctgtata 2527981 attagacaat ccgacaaagg acacctctcc cggcaaaatt ctttggaagc tcatgatgaa 2528041 gacactaatg atggggtata gaaaaaatac gagaaaggat aaaacgaatg gcgctgtaaa 2528101 cagatagggc gccgcttttt ttgaataaaa cagatctcgc cagcctgatt gtttcgcagc 2528161 tgaaggaacg ggatgaaccg ttcccgtttt cacaggtttc atgagaacct ccccgctttc 2528221 actttttgaa tgggattcta tttctgtttc agttcacctg ccgctctgtc caaggcttgt 2528281 ttaggcgttt tttgctgaga tttaagcgcg tcgaacaata cgcttctgtt gacaaggtct 2528341 gaagccttgg caaaatcctc atgtaaataa attggattga tttcatcctt gatatcgagc 2528401 agcacagaaa aaatgcctgt tccgttttgg aagtaatccg tgtatttgtt tttctctttc 2528461 aattccttgg agctccaaac atcccagcga agcgggtcaa agccgagtac gctccagagt 2528521 tttttatttc cttcttcaga gcccttcgca aaggccaaaa actcttttgc taactcaaca 2528581 tgcttggatt gcttcggtac aacagttgcc gtaccgccca aacctgccga gcggtcgccc 2528641 ccctctttcc atgccgggag cggtctgatg gcaatcttcc ctttcagatc aggcatataa 2528701 tcgataaatc ttcccatata ccaaatcggc atgagaactg aagcagctcc tccttggttc 2528761 ataaagccgt agtattcttc actgtgatgc ccgccgcccg gcgcaggaat catcgtttta 2528821 tcattgatca tgtcttttaa atattgaagt gtttttacgt tggtgtcatt attgaggatc 2528881 agcttgccgt ttttatcaaa atagcctgag ttttgctgtg aaatcataga taagaacgtt 2528941 gcggaatcat ttgtttccac cgttcccatc ggcttcccgg tcactttgcg cactttctgt 2529001 ccggctttat ggtaatcatc ccatgtttta atatcgtcag gattgacgcc ggcttttttc 2529061 atcacatcca tgttataaaa catgaccgtt gtccctacat gtgtatcgag tccgtaaagc 2529121 tttccgtttt tgctgtacaa tgtcagccgc gcctcaacga atttatcgcg atccttttca 2529181 atcagcggag tcaagtcggc aagcggtatg tcagagccct tcaaaaagtt tgaaaaacgg 2529241 gccaattcga catctgcaat atcaggaacg ccttctcccg ctattaggga gatagataag 2529301 ttatcgtgca tttgtccata tggataaacg accgtattca gcttaatttt gcggtcagga 2529361 tattttttgt tccattcctt caccatttcc acatagaact gctcatgaag cccgttaaat 2529421 gtccaaaagg tcagctcagt ttcacccgat ttgccggatg atttttctgc tgaacacccg 2529481 gcaatgacta atgtcagcaa catcatgagc acaagaaaac agacagtcat ttttttcatc 2529541 tgcgttaccc cttccattcg aggtgcgggc tattcatata gaccatggtt gatcagcgtt 2529601 ttgttttcat tgatgattct taatccggtg catcggtctc ttaaggtgtg cgcgtgtctg 2529661 aaggcatttt tgacggaatc ctgcccgaca ccgatttcgt caaaatacgc agggcctccg 2529721 gctgatctca gccaatcagc cagcacttct cctctcggga gtgtttgata agccgattgg 2529781 atggcttccc ggcggcttgg tgaaaattcg ttcagcccgt catcctgagc gagctttctg 2529841 tatgtgtcag ttaataaaac agcggcacag cccacctttg ccccatgaag aatctgaggc 2529901 cgttttttct ccattaactc catttcaatc caatgtgaaa tatgatgctc gccgcctgat 2529961 gccggtcggg aatgatctaa tgccagcatg acaagccccg atacaagtaa agactccatc 2530021 aaaacccgta tgccagtttc cgttttcatc gcaatgtctt ctgtgtgttc aatgcaggca 2530081 gcaagcgcct cctgaacgat cttagctcct gcaggcgaat aaggctcacc ggcaagatgc 2530141 cgggatattt cccaatctgc taaagacgtg attttaccga gcatgtcacc aaagccagcc 2530201 gccaccattg actgcggtgc cgcttttaat agatccagat cagcgaacag cgcagatggg 2530261 gccttcgttt gaatggttgt tttcgtgccg tataaaataa tcggcgcacc ggctgatgta 2530321 aaaccgtcta cagatggagc agtcggataa gaaataaacg gcaaatctct ttgaaacgcc 2530381 gcaaagcgga cgatatcatg aatcgtgccc gaaccgactg cgatcatgac atccgttggt 2530441 tgtttcgtat ggatcagcac atgaatgagc gatcgttcat cagctgtcac atctccggct 2530501 tcattttctg gaatgatcag gcactcggcc tgaaatcctt cttgattcag tcggttttct 2530561 aaatcaattc ctgcaatgcg gtgtgtattc gcgtcgcaga caaggacaat atgttgattg 2530621 ttttttcgtt ttacataatc caaaagcgaa tcagctgctt gcttaccgag aacaatttct 2530681 tcaactttta taggcaacgt cttttctccg gcgttttcaa aagcacgctg aacgtcagct 2530741 gcgatacgat tcatatcaga atcccctcct cagccaattt ggttacatcc ttaatagaat 2530801 ccagcacata atccggcgtg tacaaacgct gttcaccctg tttcgcagaa ccagttagca 2530861 ctaaggcgct tttcatgcca taaagcttcc ccatcgcaat gtcagattca atgctgtctc 2530921 ctataatcat gcattcatgt gcggacagcc ccattgctgt acaggcagcc tccgccatca 2530981 gccatgacgg ttttccgaca acaagttcag tcttcgcttg tgcagaagtc tcaattgccc 2531041 cgatcattcc ggccacatca atggcatttc cgtcttcgtt cggaaaagag cggtctttgt 2531101 ttgtagcgat aatacgagcg ccgccggcag ccgcttgaaa ggcttgattt aaatcgtcgt 2531161 acgtgagcgt ttcatgaagg gagatcacga gccaatccgc ttccttcggt tcgctcgcgt 2531221 tctgcacacc ggccagcctc agctcgtcaa ccaagccttg ctccccaagc acccatacct 2531281 ttgaaaaacg ataatgtttt ttcagaaaag ccgctgtcac gcttgatgac agaacaatgt 2531341 cgtttacgtc cgtttcaatc cccgcgccaa gaagtttttt tctgcacatg gcacgggaga 2531401 tattcccccg gttgcttaaa aagacgattt tctttcccat tctcctaagc gttttgatcg 2531461 cttctcttgc tccttcgatc aactcatttc ctctgaatac agtaccgtcc aagtcaatca 2531521 gaatgccagc cggtgacaca ggcgtatcat gactggccat aatacgcatt tgctccgtgt 2531581 tttcgataaa aatgcttttc atgcaggact gtattgattg gggttacatc cttgttcagc 2531641 ataatggagt gataggccat ttcggcaacc gtttctaata caactgcgtt atgaatggca 2531701 tttaaggcgt cagtgcccca gcagaacggt ccgtgattat tcacgagcac acccggcacc 2531761 tgttcgtaat tatgatgctg aaaggtttcc gctatgactt ttcctgtatt cagttcgtag 2531821 tcatgaatga tttcttcatc gtacatttct cgagtacatg gaatcgcact gtcaaaataa 2531881 tcagcatggg tcgtgcctaa cggagggatg tctctgcccg attgcgccca gcttgtcgcc 2531941 cattgagaat gggtatggac aattcccccg atattcggaa aggctttata tagataaaca 2532001 tgggtaggtg tatctgaaga aggtttaagc gagccttcga cgacctctcc atcaaggttc 2532061 aaaacaacca agtcatcggc tgtcaggtcg ctgtattcga ctccgctagg tttgatgaca 2532121 attctttctt tttcacggtc aatgccgctg acatttcccc acgtaaaggt taccagctga 2532181 tgctcttgaa gcttcaggtt ggcagccagc acttcttttt ttaatgtttc aagcatgctc 2532241 catcaccctt tatcaattct ttttggcggc agatgaaaat tgaagatttt tgatcgtttt 2532301 cagacgcttc atgacatggt tttcttttcc gaaataatga accagctctt tatattcagc 2532361 gtacaatttt tcataaaccg cggcgttttc ggcatttggc gtataagtta tatctttcag 2532421 ttttcccatg ttcgccgctg cctttttgat atcatcgtag ccgccttttt ctttgcctgc 2532481 tgcaagcgcg ccgaaaatgg cagatcctaa ggctggggct tgcggtgaac cagagatttt 2532541 aatgtccatg tttgtcacat ccgcataaat ctgcatgaca aacgggtttt tctcagctat 2532601 tccgccggct gcgaacagtt cctcaatcgg aacaccgctt tctttgaatg tttcgataat 2532661 catccgggtt ccgtaagctg tcgcttcaac taacgctcta taaatctctt caggcttcgt 2532721 cagcagtgtc atgccaagca gcatccctgt taaatctgca tcaacaagag ttgaacggtt 2532781 tccattccac caatctaaag caagcaagcc gctttcacca ggcgcttgat ggtttgcttt 2532841 ctcactcagc agctcatgaa cgccaatgtt tttttccttt gcttcctctt gataagctgg 2532901 cgggacacat gttttcacaa accagtcaaa atgatcgccg acacaggact gcccggcttc 2532961 atatcccgca tagcccggga gaattccgtt gtccacaacg ccgcacattc ctggaacgat 2533021 atgcacctct tcaccaagta gaacatggca cgtcgaggtt cccataatca tcagcatttt 2533081 ccctggctct gtaatgccga ccgccggtac cgaaacatga gcgtccacat tggcaaccgc 2533141 aacagccgtt cccgggagaa gccctgtcag ctttgccatt ttttcagtca gactgccggc 2533201 tttttctcct actgaatgaa tagaacctga caatttgtcc tttgtaatcg ttttcattga 2533261 aggatttaat ttctcaaaga aatcatctga cggatacccc gctttttcac tccacatcgc 2533321 tttataccct gcggtacaat tgcttcgctt gagcgagccg cacagctggt acacgatcca 2533381 gtccgcagcc tcgatgatcc ggtcagccgc ttcataaatg tgaggcgctt cctcggcaat 2533441 ttgcatgacc tttggaatca tccattctga tgaaattttt cctccgtacc gctgtaaaaa 2533501 agcctctcct tcttcttccg cgatttgatt gagccgatca gcatgttttt gggccgcatg 2533561 atgcttccag agcttcacat agctgtgcgg ctcctcttca tattcaggca gcatgcataa 2533621 cggctgcccg ctgctgtcaa taggaaggat cgtacatgcc gtgaaatcaa ttccaatccc 2533681 gataatgtct ttcgggtcaa cgcccgtctg ttcgagtaaa gacggaatgg ttgtttccaa 2533741 gacttcgagg taatcagcag ggtgctgcag cgcccagtca cgcggcagct tttgacccgt 2533801 ttttggaagg acggtatcaa tgacagcatg cctgtattct tttacagcag ccgcaagttc 2533861 ctcccctgtt tggacatgaa cgagcactgc tcttcctgat aaagttccaa aatcaacccc 2533921 tattgtgtaa gccatgtgac atccccctct acttttgaag ccggtaaagc gcctcgttcc 2533981 attttaactc gtgtttcagt ttatgaattg tcgtatcacg ggaaatgaga acactttcga 2534041 ttcccgccat ttccgcccaa tcaagcattt gctccgctgt cagttcataa gacaggcagg 2534101 tatggtgtgc accgccggct aaaatccatg cctccgctgc tgttttcaat gacggctccg 2534161 gcttccagag aacacgggca accggtaaat tcggcatgtc tttttcaatt tcctggccgt 2534221 tgacttcatt cagcacaagg cggaaacgcc cgccaatatc aacaatgcta gcttgaatgg 2534281 cagaaccgct gatgccgtta aataccaaac gcgcagggtc ctctttgccg ccaatcgaaa 2534341 gcgaatgaac ctcgattttc ggctgatcca aagcgacagt cggacacact tcaagcatgt 2534401 gagagcccag aatcatttca tttcccggtt caaaatggta cgtgtaatct tccatgaagg 2534461 aagttctttt tcctttagcc atgattttca tcatccgtac aagggccgct gtcttccaat 2534521 ctccttcacc ggcaaaccca tagcctttct ccatcaggcg ctgaacggca agtcccggca 2534581 gctgtttcat tccgtgcagc acttcaaacg atgtcgtaaa cgctgtgtat ccgccttgct 2534641 caagaaaagc ggttaatcca agttcaattt tcgcctgttc tttaatggac gctacctttg 2534701 cttcgtcacg ttttgtttcc tcactgatca catatagtct gtcatactcg gcataaagcg 2534761 tgtcaacctc gtcgtccgta atgcgatcca tcacttcaac gagatccccg atgccatatc 2534821 cgtcaacctg ccagccaaat tgaatatgcg ctcccacctt gtctccgtcc gttaccgcga 2534881 catgacgcat gttatctcca aatctggcaa ccttaatatg tctgctttca tttaatgcag 2534941 ccgccgtatc catccactgg gacatttctt ttttcacttc ttcatcatcc caatagccgg 2535001 caatgacttt tcggctaagc cccattctcg agttgatgta accgtactct cgatcgccat 2535061 gcgcggattg gttgctgttc ataaaatcca tgtcaatcgt accccacggg atatcgcgat 2535121 tatattgggt atgcaaatgc ataagcggtt tttgataaga ggaaaggcct tctatccaca 2535181 tttttgcagg ggaaaatgtg tgcatccatg taatgatgcc agcacatgtc tcactgtact 2535241 ccgcttctct taacagctct ctaatggttt ccggtgaagt gacgacgggc ttatgagtga 2535301 ttttatatct ggaagaaatc ccgctgagcc cctcacaaat gcttttagca tgctgatcta 2535361 cgagttccag cgtctcttcc ccgtataggt gctggcttcc tgtcacaaac cagaattcat 2535421 aatcctttgt ctgaagcatg taaactgccc ctttctcata aaataaaacg ctttcaaata 2535481 caaaagatac gtactaatga tagaaaataa acctataaat aaatatttgt acgaacaatt 2535541 ttattatagt aattgactat tatactgtca atcttttctt ttaaaaaaag ccgggggcag 2535601 agcccggctt tttaattcaa taggacggcc agcccgagct ccaattcaaa tcattgatga 2535661 gaagctttgg aatgccgttg tcattggcat cataggcatg gcgaacaaga atgtttccgt 2535721 tcacaatatc ctggcctcca ggtcctttcc attggtcatt gcccgaatcc aaaatggtgc 2535781 ctccgccttc aagcatgctt tttccgcttt tatcaagata agggcctgta atgcttttgg 2535841 atcttccgta agcaattttg tacgtactgt ttaccccgtc acagcattta tcaaatgaaa 2535901 ccattaaata gtaatatcca ttttgatacg taagagtagg agcttctaag gcacctccat 2535961 tattcggtct agctgcaatc gaatagagcg agcctgtagg cttcattgta ctcttatcga 2536021 gcttagtcag cttaatgccg ctccaaaacg agccgaatgc aagccacggg ttgccatcct 2536081 tatcgaatgt cagctccgga tcaatggcgt tataattatt tgagcttgtc gaacggatca 2536141 ccaagccctc gtccttccag ccccccgaac tgatgcttgt tgaagatgcc aggccaatgg 2536201 cagatgtatt gcttccaaaa gaagaaacgg aataatatag ccagtacttg ccgttatagt 2536261 attggatgtc cggcgcccac tggttttggc cataattcgg cacataattg gaccaccacg 2536321 atagcggtgt agtgaaaatg gatttttgta cggtccaatt tttagcgtct gaagacttca 2536381 aaacccgcag tccccgttct tcagtaagcc ctgttccgag cgcataccat gagctcccct 2536441 ctttaatcat agtcgggtca tgaagcagct cattggatgc accccaaaac gctgcctctg 2536501 cgggagcagc agaagtgaat atcaaacctg cagccagagc tgcactcgaa aagtgtaaga 2536561 agcgtttcca tgtttttttc tttttcaatt ttgttcaacc tcctttattt tagaaagcgc 2536621 ttacaaatta gattatttat cctcccttcc tgtcaaatcg actgcgtatc gtatatcgtc 2536681 atgttcagga aattttcggt atccccttta ttgtagtcac tatgctgtaa tttgtacaga 2536741 caaaaaaata gaatccacct caataggcgg attcttccgt atctttattg gtacgtaatt 2536801 tcgtcaaccg tttttcggtc taacttctta atgacttctg taattaactt taccgcgttt 2536861 tcataatcat cacgatgcag catggccgcg tgcgtatgaa tgtagcgggt tgcaatggta 2536921 atggacagcg caggaacgcc atttgccgtc aaatggatgg cacccgaatc agttccgccg 2536981 ccggcaatgg catcaaattg gtacggaatg ccggcttcct ccgcagtggc tacaactgca 2537041 tcgcgcaaac ctttgtgaga gaccatggat gcatcgtaaa cgataatctg cgggcctttg 2537101 cccattttgc tctgcgcttc cttctcggaa atgccaggcg tgtctcctgc tatccctaca 2537161 tcaacaccaa acgcaatatc aggctgaatg gtgtgtgcag ccgttttcgc tcccctcagc 2537221 ccgacttcct cctgcacggt tccgacgcca tacactatat ttggatgatc tgtgttttgt 2537281 aagtttctta acacatcaat agcaatcgca cagccgatgc ggttgtccca ggcctttgcg 2537341 agtaggaatt tttcattgtt catgaccgta aattcaaaat gcggaacgat catatctccc 2537401 ggaagtacac cccactccaa ggcttcttcc cggcttgaag ctccaatatc aataaacatg 2537461 tcttttattt ccactgattt ttttcttgct tcaggagaca aaatatgagg cggcttagat 2537521 ccgataaccc ctgtgatttc tccttttttt gtgacaatgg tgacgcgctg agcaagcata 2537581 acctgagccc accagccgcc aacggtttga aaacggataa agcctttatc tgtgatttgt 2537641 gtcaccataa agccgacttc atccaaatgt ccggcgatca taattttcgg gccgttttct 2537701 gcaccagttt tttttgcaat taaactgccc aggcgatctg ttgtcacctc atcagcaaat 2537761 ggttctatgt atgatttcat cacttgcctt acttctcttt cattgcccgg tatgcctttt 2537821 gcatctgtta aatctttcag catggtcaat gtttcatcta attttgccat gttccaaacc 2537881 ctccttcatc agtcctgcat tcttattata caaaacatgg cgctaaccat acgactattt 2537941 cacttgaaaa tcgggtatat gtttttacag ctttctttta gaaaaagtga aacctttttc 2538001 tatgcttttc gtattacatc agatcatcac cataagggag gtgccttcac acaatgtttg 2538061 tcatggttct aaggattatt ttgcttgcac tttttgctta ttgtatttat gccgtggtca 2538121 aatatgtcgc gaatcctaag agaaggctta agctggccca atcaaaagaa catttttata 2538181 ttattgatga acaaaacaat acccggaaga attttcagct gacgtataaa ggcgtgcttt 2538241 ttgagggaga aaagcatatt ccttccaagg atcatccgct gtttattcac acgatctttg 2538301 tctggacaga atctcctgag aagctgaaac atttctctgc aaaagatttt gagaacattg 2538361 aagaaaaagt gctggaacga tatccaaatt gtaagattga ctgggaccag cccattaaac 2538421 tcgcaaaaaa agcagaagag cgttaaacgc ttttctgctt tttataaatc aaacgggctg 2538481 tagtaaatag cgatgagaat cgcttctatt accagaagaa gcggtactcc gtacttaaaa 2538541 gaagcgtgtt tcgttttatg tctgaaggtt tgcatgccaa gccagacacc gagcgctcca 2538601 aacacgatgg ctatcagcca cagccggtct tcagaaattc tccacttgtg ctgctgcgct 2538661 ttgcgtttgt caatgcccat cacccaaaaa ccgcacagat taatcaacac caaataagca 2538721 gcaataatca tgttgcctca tcctttatat agaaaaagcc gctctgctgg agagcggctc 2538781 tatatgatta cttgtttaat tgagctttag cagcatcagc aagctgattg aatgcagtaa 2538841 gatcgtttac agcaagatca gcaagcattt tacggtttac ttcgatacca gaaagcttaa 2538901 gaccgtgcat taaacggctg taagaaaggc cgttcatgcg agcagctgcg ttgatacgag 2538961 tgatccaaag tttacggaaa tcacgttttt tctgacgacg gtcacggaaa gcatagtttc 2539021 cagatttcat gacctgctgg ttagctactt tgtataatgt atgttttgaa ccgaaataac 2539081 cttttgctaa tttaagaacc tttttacgac gcttacgtgt aacagttccg ccttttactc 2539141 ttggcattga atttccctcc taattgttcc ttatccgatt acttgatgtt agcaagcatt 2539201 tgtttgatac gtttgaagtc tcctgcgctt acaacagcac tcttgcgaag cttacgcttt 2539261 tgcttttgag atttgttggc gaataagtga cttgtgtacg cgtgagaacg ttttaacttc 2539321 ccagaacctg tctttttaaa acgtttagca gatccgcggt gagttttcat ttttggcatg 2539381 ggatttcctc cttattgctt ttcgtttttc ggtgcgagca ttaagaacat gctgcggccg 2539441 tccatttttg gttttgtttc gactgtcgca acctcagcac atgcttcgga gaaacggtct 2539501 aatacacgct gaccgatttc tttatgagtg attgcgcgtc ctttaaagcg gatagaagct 2539561 ttcactttat cgcctttttc aaggaattta atcgcattgc gcaatttcgt gttaaagtca 2539621 tgctcatcga ttgtcggact taaccgaact tcttttaagt taatgatttt ttgattcttg 2539681 cgtgcttctt tttccttttt ctgctgctca aatcggaact taccgtagtc catgattcgg 2539741 cagacaggcg gttttgcatt cgctgcaact aacacaaggt caagatttgc gcggccggcg 2539801 atttcaagtg cttcctgacg ggacttgatt ccaagctggt cgccattttg tccgattaaa 2539861 cggacctcac gtgcacggat accctcatta accaattgat ctttgctaat aatgagccac 2539921 ctccatagtt tcttcgaatt gattcacaac tcattttgaa tgcattttgc aggcaaacaa 2539981 aaagtgtggg cattataaaa cacccacact acgaacatct gtatcaataa aaatgtacgg 2540041 tcaacctgcc aactacatgc atgtgtcaat caggtgagaa gcgggtgctt ctgcttgtga 2540101 tttatattca attcaataac tattctacac aataccggat ctttagtcaa ggacgactta 2540161 tccggaacaa cttttacatt gtaacatggg ttttctatga gcgcaagaga gaaaaagaaa 2540221 atctttcatc cccacccaga atacaaagaa ccaacaattc ccccttatta cgcaatttac 2540281 aacaaaacca ccgacaggaa gaaatgtaaa acaaagttaa tctctgaccg atataaggag 2540341 cagaagggag cctgacacat gaacaaactg atacagcttg ctttattttt cacattgatg 2540401 ttaaccggtt gctcgaatag cagcacatct tccgaatcaa aagtcgaaac cactgttaag 2540461 acaacggcag catttcctca aaaggagctg gagaaagagc taaaaaaact aaaacccgtt 2540521 tcattggaca tgaagttcga gagtccactc gctaccgagt taggaaagcg gaaggcaaaa 2540581 gaggaagctg aaaagcaaag acaaatcgcc gctgagaaaa agcttgaaaa agagcgggag 2540641 gcgaaacgaa agaaacagca ggaggaaaaa gcggagagac agcgattagc agagcagcag 2540701 gctgcagaga gacagcgatt agccgaagcg gaaagacaag ctgaacttga aagacagcgg 2540761 caggcagcaa tccaaaaaga gcagaaagcg aacgctgaga aaaagcggca atcgcaggca 2540821 caacggcagc agactgaggc accctcatct aatagtcaag atccaccatc ttcctcgagt 2540881 cagacagata aaaccattca acagccagct tcagagcttc ctgatgacga tggttatggt 2540941 tatgaagaac gaaaaaagtg gcatgacgat caagtagaat ggggcattaa acaagggtat 2541001 atcgatcccg aagacgcacc ataaaataaa aaaagccaag gcattcagcc ttggcttatc 2541061 ctccgatcag ctgcacgaac acagggatga ccagaaccgt taccactcct actacgacaa 2541121 cagcaatact tgccatcgca gcttcaactt ctcccatctc aatcccgacc gctacaccaa 2541181 gtgcatgtcc ggatgttcca agagccaatc ctttagaaat cggatttttc actttaaaca 2541241 ccttcaagaa caatgctccg agcgcatata cgatgacagc gttaaagatg accgcaaagg 2541301 ctgtgatgtc gctgatgccc ccgatgcctt ttgataaagg aagcgcaatt gccgttgtag 2541361 ccgcctgcgg aagcatgctt ttcattacgg ccgaatcgag atgaatgcct ttagcgagca 2541421 gataaacaat cgtgacagag cagatagagc cggcaataat ggaggccatg atttgccacc 2541481 agtacttttt aagcttatct ctttgtttgt acaaaggaat tgcaaatgcg atcgttgccg 2541541 gttcaagaaa aaacttaatg atctctcccc cgttattata atccgcgtag gaaaaaccgc 2541601 cgatttttaa aaatgcgatc cccagcacca tggcaacaaa caaaggagtg aaaaggaaga 2541661 agcctttcgt tttcttaaat aaaaaggtgc cgatgccgaa tgcagcaagt gatacgacaa 2541721 tcccaaaata aggactcatt gtgctttcca tgtgaagaac ctcctgtttc ccttaatggt 2541781 gaacgagttc gttattgttc tgcgggcttt gcactgtttt tgttttcatg tccgcttcgg 2541841 ttttgcgttt tccgctcagc gacagaatca gctgagaaaa caatcccgta gcccccagca 2541901 aaataatcgt tgcgagcaga atgacaagaa caatttgcag gccgtattgc tgcatcacac 2541961 caagcgaatt cataacagat atacctgatg gaacaaataa aaatccgatc agagaggtta 2542021 aagacgttcc gagcgtctcc acttgttcca gtttaatgac tttcaaacat aataggagaa 2542081 ataataagac caaccctaca accgatgccg ggataggtat tgggacaata gcggcaatca 2542141 tatttgaaac cagcataatg acggcaaaaa taaatgcttg tgttaaaaac ccgtacactt 2542201 ttttagcact cattttcttc acctctttct ctttggtacc ctcattataa ataagaattc 2542261 cctgttataa agcgcttaca agataacatg ccgtatagcg ggtctgagtt gcagaatcaa 2542321 atggctgaaa tgcaaaaagc cgcccatcaa atatggagca gctttttcaa ttccttcgca 2542381 tatgtccggc tgaccggtat tttcgatccg tctttcatga tcagattata cgttgaatta 2542441 aaccatggct gaatttcttt aatatattca gtattcacga caaagctccg atggacgcgg 2542501 ataaaatcag aatccggcag ctttttctca atcacaacga gtgtatcgct gaccgtataa 2542561 gaatgatcga aggtttttac attgacatga ccatcttctg ttccggcata gataatgtcc 2542621 ttcgtatcca caatcacaat cgattccccc acagatagcg cgagcttgtg ctggccggca 2542681 tggctgtttt gctctgtttc tacaatatcc cgattgactt ttttatattt tttcagcgtt 2542741 tgctgaattc tttcttcatc gaaaggcttg gttaaataat caagagcgtc cacctcaaac 2542801 gctttgagcg catactggtc atacgctgtc gcaaacacaa tagcaggagg atgcttcatt 2542861 ttcttcaatc gctttgcgat atcaaaaccg ttttctccgg ataaatcaac gtctaaaaac 2542921 agcaaatcag gtttttgatc catcatttgg tcaaaagcgg attcgatatt ttccgcttca 2542981 ttgatttcca tttcatcatt ggtccgctta agcaagtaag ccagttcatc ccttgccagc 2543041 atctcatcat caactattaa caccctgagc atgttcttct ccctctttca tctgttgcat 2543101 tggcacttga aaggaaacct ctgtcccttt atgaacctca ctgctgatat gcagtgcagc 2543161 ctgctgtccg aataaaccga tcagccgctg atttaggtta taaagcgctg taccggttcc 2543221 ctccttagac ggaaacggtt tcttccccag ttccggcaag acgtccggcg gaattccgcg 2543281 tccgttatcc gccaccttca tatagacgga tgcatcatca gataagacac agactgtaac 2543341 cttgcatatg tcttgttttt tcggaaacgc gtgccgaagc gcgttctcga caagcacctg 2543401 caaaacaaac ggagggattt caatctgctc cagtctgctg tcgatattaa gctcaatttt 2543461 atatttcccg ggaaaacgcg cctgttctaa tgacaaatag gcgttaagat ggttcagctc 2543521 ctttgagagc ggaatcagca gctgtctcgc tccttgaagg tttgaacgaa aataaacact 2543581 gagctgcaat aggagcttac gggttttttc aacatctgta cggcataacg cagaaatcgt 2543641 gttgatcgca ttaaataaaa aatgcggatt cacctgtgct tgaagcgctt taatttcagc 2543701 atccttgaga agtttgcttt gcagctctgc ttccccaagc tcaagctgtg tcgaaaacag 2543761 catggccagc ccctcggcaa gttcctcctc tacctgactc aggcctgccg ggcttttaaa 2543821 gtacattttt aaggtgccga ttgtattgcc gttcgatgtc agcggtagga caattgcagc 2543881 gtgcaaaggg cattcagcat gcgtgcattc aatctcttcc tgcgaaatcg ccttcataat 2543941 atgccctgtt ttaatcacct ttttggacag gccggtgatc aagcttttcg atgggatgtg 2544001 gtgatccatt cccgcaccga catgcgcaag gatcttttct ttgtcagtga gagacaccgc 2544061 atctgttcct gtcagcttat ggataatagc cgctacactt ttacaggagt tttcatttaa 2544121 tccttggcgg aaaaatggaa gtgtctgatc agcaatcgta agcactcgat gcgtttcgag 2544181 agcccttgcc tgttcttcct tgcgaatgat cgcttgaata atagacagaa aaataaaact 2544241 gcctgttcca ttgatgagta tcatcggaat tccgatcatg ctgacaagct cccaagcgtc 2544301 actgaacggc tttgccatca gcaaaataat gatcatttgc agtgactcca tgccgattcc 2544361 cacaagagcg gcgatgcgcg gtgtcggcat tcgatatcgc ttcgtaaaat acctgccgat 2544421 caagcctgca agaacacccg ctaaaataga tgagacggca cagcttaagg ccgtgctgcc 2544481 accgagtgaa aaacgatgca ggcccgcaag tatgccgatc ccagccccta caaaaggacc 2544541 tccgagaagg cccccgattt ccacgcccaa aatacgggta ttcgcgatag agcccgatgg 2544601 atctatcgta aacacccagt cattgtttac aatcatattt ctttgaattt cgatgcctgt 2544661 ataattgctg atgatgctga aaagagaaaa aatagaaatt aaaatcgctt ttcctttata 2544721 gccgtcctga ttctgaagag cttgtctgaa aagtttcgta tgggcgagaa tgaaccctaa 2544781 tataacaata atccccactc tctccagcat cataatcatt aaatgaatca ttcatgtcac 2544841 ctgttctttc cgttttcatt ctagcatgtt ttcgttttgc ggctgactgt ttttttaaaa 2544901 tcgtctgaaa acatatttca caaggctttt atctattgta aaataaaaca tgagcctttt 2544961 ggcagaaaga tttgaatctg aagcagagga gaagatcatg aaagccgtat tttttgattt 2545021 agatgataca ctactttggg acgaaaaaag cgtcagaaca acatttgcag aaacttgctt 2545081 acaggcggag aaaaaatatg gccttgcccc tgaggaattc gaagcagctg ttcgcgaagc 2545141 ggcgagagaa ttgtacatgt catatgagac gtatccatat acagtgatga tcggcattaa 2545201 cccgtttgaa ggactgtggt ccaatttctc agagccaatc agtgaaggct ttcaaaagct 2545261 gaacaagatt gtgccggagt acagaagaaa tgcatggacc aacggactga aagcgcttgg 2545321 gatcgatgat cctgcatatg gcgaatactt gggagagttt tttgcggcag agcgcagaaa 2545381 gcgcccgttt gtatatgatg aaacttttgc tgtactcgat caattaaaag gcaagtatga 2545441 attattgctt ttgacaaatg gcgatcctag tctgcaaaag gagaagcttg ccggcgtgcc 2545501 tgagctcgct ccttacttca atgaaatcgt catctcgggc gcattcggca agggcaagcc 2545561 ggatgtttca atttttgaac actgccttaa gctgatgaat attgaaaaag acgatgccat 2545621 catggtcggc gataatttga atactgatat tttaggcgct tcaagagccg gaatcaaaac 2545681 cgtttggatc aaccggactg ataagaaaaa cgaaactgac gtaaagcctg attacatcat 2545741 cagcagcctt catgatttgt ttcctatatt agagaaataa aaaaagcatg atctcttcaa 2545801 tgagatcatg cttttttatt ttattttttc gcttcagcta ctgccttttt cacaaactca 2545861 tcaagtgaaa tggtttcaga gttctgttct ccgtatttac gcacgtttac cgctccgttt 2545921 tctgcttctt ggtcaccgac caccagcatg tacgggattt tttgcatttg cgcttcacgg 2545981 attttgtagc cgattttttc atcgcggctg tcgacttcaa cacgcaggcc ttcacattgc 2546041 aggcgttcct gcactttttt cgcgtagtct aaatgcacag ccggagaaac cgggatgact 2546101 tggaactgaa ccggtgcaag ccatgtcggc agcgcgcctt tgtgttcttc gattaagaaa 2546161 gcaacaaagc gttccattgt tgaaacgaca cctctgtgaa tgacaaccgg acggtgctgc 2546221 ttgccgtcct caccgatgta tgtcaggtcg aaacgttccg gcaataagaa atcaagctga 2546281 accgtagaca gtgtttcttc ttttccgatc gcagttttca cctgaacatc aagtttaggt 2546341 ccgtagaatg ccgcttcacc ttctgcttcg taatagtcgt ggccgatttc atccattgcc 2546401 tctttcagca tggattgcgc tttgttccac atttcatcgt catcaaaata tttctctgta 2546461 tcttccggat cgcggtaaga cagacggaat gtgtaatcac ttaaaccgaa gtcttcataa 2546521 acatcctgga ttaaacggac tgtacggata aactcatcct taatttgatc cgggcgcaca 2546581 aagatgtgtg catcatttaa cgtcattccg cgtacccgtt gaagtcctga cagcgcacct 2546641 gacatttcat agcggtgcat cgttccaagc tctgcaatac gaatcggaag ctcgcggtaa 2546701 ctgtgaatgt cttgtttgta aatcatcata tggtgcggac agttcatcgg acgcaataca 2546761 agtgtttcat tgtccatttc catcggaggg aacatgcctt cctgataatg atcccagtgt 2546821 cctgatgttt catacagctc tttgctgcct agcacaggtg tgtatacgtg ctcatagccg 2546881 aggctgattt ctttatcgac aatgtagcgc tcgatgacgc ggcggattgt tgcgcctttt 2546941 ggcagccaaa gcggcaggcc ttgtccgact ttttgagagt tcgcgaacag ctttaattct 2547001 ttgccaagct ttctgtggtc gcgttctttc gcttcttcta gcatacgaag atgctcttca 2547061 agatcagctt ttttgaagaa agctgtacca tatacgcgct gaagcatttg gtttttgctg 2547121 tcaccgcgcc agtatgcgcc tgcaaggctt aacagcttaa attctttgat ttttccggtt 2547181 gaaggaacat ggacgccgcg gcacaggtca aagaattcgc cttgctcata gatcgaaacg 2547241 gtttctcctt caggaatcgc atccaatagt tcaagcttca ggtcgtcgcc gatttccgca 2547301 aaacgggctt tcgcttcttc acggctgact tcttttcgaa cgatcggaag gttcgcatta 2547361 acgatttttt tcatttcttt ctcgattttc ggcagatcct ccggtgtaat cgcttcgtcc 2547421 atttctacat cgtagtaaaa accgttttcg ataaccggac cgacgccgaa tttaacatcc 2547481 ttgtagatgc gtttaatcgc ttgagccagc aagtgagccg cactgtggcg cataatttga 2547541 agaccttctt ctgagccttc tgtaatgatt tccactgtac cgtcttcatt gatcggcgtt 2547601 ctcaaatcga tttcttttcc gttcagtttt ccggctaatg actttttctt taatcccgga 2547661 ctgatggatg ccgcgatatc ttctgttgtt gttcctttcg caaactcctt gactgctcca 2547721 tcaggaaatg tgatttttac catatctgac atctttgtca ctcctttttt tgcatataaa 2547781 aaccccgccc cctatgaaag ggacgaggtt gaataaacgg aatcgtggtt ccaccctttt 2547841 ttccgcaaag ccaatacacg gcacctgcgg ctctaagctc tgtaacggga gttcccgtca 2547901 gccattactg ttccttttca agaggttcac agctgaagtt caaaggcggt aaagcgaatg 2547961 gtccttagct gggaagcttg cagccagggc ttccctctct ttgagccggt atcattcctt 2548021 cgtgtcctta tcaatacgtg tgtctttctt aatctcctat gtattataaa ttgttcaatc 2548081 caaaaaatca acacgatcgc gtttcctttt ttttaaaccg acagccttaa atagacaggc 2548141 tgccggccct catccttccg agtgcttcac cggtatttct gcatctgtaa aagcatgcag 2548201 cgggagcatt tccactctct cttgaaatac gttttgaatg gtccttgcca tcatgtgctc 2548261 gggctggtcg gtataaagca cgacttcatc aggcgcaatg gaaatcagcg gcgcgagcaa 2548321 atgagaatca atatacatag gatgatcccg gacaaatctt ctgtctatgt atttcatttt 2548381 ttcccgttcc ggcacatagc gcagctccca taatgtaaag gaaccatcat ggacaatatg 2548441 cacttttttg attcgcggct gtttggcgtc cacatagtct ctgagtgttt gaataaagtt 2548501 ttgatattcc tgttccatct tatattcatc aatcgctgct tctgtaatat ctctcagctg 2548561 cttatagtat gatccaagtc ggaaggtctg aaaggagcga atgtaaaata ctccttcctc 2548621 taaacagatc gtttggagtt catccaaaat tgattgtttc cgtgaaagct tcagcggctc 2548681 aaacggaaga tcgtctgctt caccttcaat aatactgtgt gcgagctgaa ggatttgctg 2548741 ctgttcatcc tggtccgtga aacaatacgt ttcctcaatc aatgacagca tatgctcgtc 2548801 ttctttgcat tccaaaaaaa atttgaccag aatcggctcc ataaaacgct gaataggaaa 2548861 agccggattc gctttttcaa tcccgatttt tcgtatgcct tcacggacaa tgatattgtt 2548921 ccgatcgtcc gaatgctgaa tgagatgtaa aaaagcggct gcatcatggt catcttcaaa 2548981 gattatttca agcatgtttg tcccccctta cggcatctgt tacaagtata tgggggatgt 2549041 ttttaaaata gacgtaaagg tcattggcaa atcttaattt gattcttgga acaagttttg 2549101 cattttcttt ctgaagatga acggcaatga gataaacacg atatacaaag cgagcaccat 2549161 aaagaaagcg ggcagattgc cagccaaaaa gctcgcaccc agcacattaa gcgcaatcgt 2549221 cccagggatg attcccacag ccgttgcggc aaaatacggc agcgctttga cattggaaag 2549281 gcctgccgca tagctgacga aatcaaaatt gatcggcagg attctcaaaa gaaagatata 2549341 gaaaaatccg ttatcctcca tttgcttctg tatggcttca agcctttcgt aatgcccgtt 2549401 ctttttcgcc gaaaacaaac cagccgcaaa aaacgaaaca gctgaagcgc acatcgaacc 2549461 gaataacgta taaagcgtgc cgagaagcgg gccaaacgca agtccgccag ctattgaaat 2549521 aacagacacc ggaaataaaa caagtggcct gacgatggat atcccgataa acatcagagg 2549581 tgcaaagact ccgaacgaca atacccatac cctgatttct ttcggcgata cattcaaata 2549641 cgttttattt ccccaataga gtaaaccagc acctgcaagc actgccagcc atttgacagc 2549701 cgtttttcgt ttcataccct cagttccttc ccctttgaac cacagcaatt atggatgtcg 2549761 gcggttttct ccgtcaaggc ggatcggagc agccaaatat aatatccgct ccattaatct 2549821 tgcagctttt acttcttctt tttctcccct ctgcgaatac gtaaaatgat gcttcagctc 2549881 gtcaggtgag aaattagaag aaaagaacgt tggcagctgc tgggacattc tgtgctgaag 2549941 caccgttccg atgacctcat cccttaccca gcttgtcatt gattctgctc cgatgtcatc 2550001 aagcattaat acgggtgtgg tctttaccat attgagcttc tcttccaatg tctggtcttg 2550061 cagcgaattc ttaagctctc tcacaaattc aggcacataa acaatcatgg aggaatactc 2550121 tttttccgcc agctcattgg caattgcagc gagcataaac gtttttccta ccccaaattt 2550181 cccgtataaa tataatcctt tcccttttcc cgtctcatta tagcttttca ggaagtctgt 2550241 aacatgctga aacatcgcga gtctgcttgg gtcactgata tcaacttgct ggaacgtcgc 2550301 tccaagaaga tcctgctgga tatacatgct tttcataaga gactgttgtt tcttctgctg 2550361 gtcgagcttc cgtttgactg gacattcgta atactcgata tcaatagacc tcccattgac 2550421 aacaagcttc ggatggtagc cctccaacaa attgttgcag ttttcatctt ccgaacaata 2550481 ggagcaattc ttgctttgtt cgatatattc ataaagctta tttaagctct tttcgatcat 2550541 tttttggtca atcacttctt cgttttcctt caaaaatgct tgaacatctt gatctttcat 2550601 gactttttcc ttcatttgtt caagacgttt ttggaaatcc ggcctgccgg ttacgccctg 2550661 cagggaacgg ccgattggtt ccatctattc cttcaccccg catctctgtc tttaataggc 2550721 agagtatttt ttcagttttt gcatttcttc catcatcttt ttcttctgtt cttccaaatc 2550781 ctgcggatgc agcttctgct gtccggattc tgaatcggac gctgtttcct tttctgtcat 2550841 ccaatcagga agcttttctt cacgaatcac tttttggttt cgtttcgaag actttgtttt 2550901 tccctcagcc cattcaagat actggcggtt ttcttctatt gcgagcttca tcgcttccct 2550961 gaccgttttc acctttttgc gtgcccaatg cgaagcgatt ttttggatat agtttttcga 2551021 cagcttcatg tcggttttca gcatgacata ataaattaac acatttgtga cgcctggctc 2551081 gagcttctgt tcgaacataa tttcttctat gatcttcaga tcagcttttg acggctctgt 2551141 tccgtcagca atgtcctgca gaagcttctt cggggaaatc gcctccagca atgcaatcag 2551201 cttcccatcc agagaatcct cttctgccgg ttgttcgcct tcacgcagat gcaccggctg 2551261 tgttttttcc accaaatcgg gcagctgtcc gtttctttca atttgatacc agtcgctcgc 2551321 cgcttttctt aatgcctccg tcgtaatgac gtcacgctca tcaattgcgc tcatcacaac 2551381 attttgcatt tgcaaagggt caattccgta cagataagaa agctttttga ttgtgtcccg 2551441 cacctgctgg gtcatcgctt ttctcggtat catcgtctca gaaagtcccg ctaaaaacaa 2551501 atcaaaatca aacacatcct ccgttatggt gtaggacgga gactgtccga cagaagtata 2551561 ctcggacccc tcggcaagcc ttaccgtttc ctccatatcg gatgtgagct tccattcact 2551621 cggctgcagc gattcaaacg catgattaaa cggacgcgta atgtccttcg catcttctga 2551681 aatggccggg tgcgtaaaaa attgttttaa ttgctgatat ttcgtttttc cgaccctatt 2551741 atacagaaaa acattcagca ttccgtcttc aaaaaattca tttggtctga gcggcggaag 2551801 gagttcatat ataaagaggc gctcctgccg ctcggattct ttcatatata ctttcagcaa 2551861 tccgatgccc tcgagcttcc cctgttcctg atggatcgtt tttaagttgg actgtgtcat 2551921 ccccatcagc tgtctatgtg tggactctcc gccccacaga cggttttgtt caagctctcc 2551981 ccacaatgtc atataaagag agaatgcaac agggccgatt aagggctggt acagttgtgt 2552041 aataatttgt ctgtcaatat cctgcagcat cgatctgctt ttaaccacat acgggtctac 2552101 aggcagtaca tctttccaat agtcagccat acattctcaa accttccgaa tttgtttcta 2552161 cctttcattt tacaccgttt cttatatcta tcaaatgcca attttgcaca tgagaaaaga 2552221 gctagaagaa tcctcttagc tcttttaacg ctctttcttt attaagtctt ttaattcatc 2552281 gataaagacg tttatatctt taaactgccg atagacggac gcgaaccgca catatgcgac 2552341 ttcgtcaatc ttagccagcc ggtccatgac catttctccg acgagctcac tcttcacctc 2552401 ggagcagcct tgattgcgaa gttctttttc aatatcaaag cacatgtctt caagcgtttt 2552461 gagtgaaaca ggcctttttt cacatgcttt tatgaggccg cgcagcattt tttctctgct 2552521 gaattcctca cgcacacctt cttttttcac aacgatgagc ggggtttcct ccactttctc 2552581 aaaggtcgta aaccggtagt ggcaggattc gcactcgcgt cttcggcgaa tcgactttcc 2552641 gtcatccaca ggccgtgaat caaggactcg tgttccgtta tgctggcatg aaggacattt 2552701 caataaaatc agctcccaac tatatcgttc cctgcaatgt attttcggca gcctccgcct 2552761 tttaaaaata gatgtgacag catctgtcgg gagagccgtt gttaaatttg tttctatagc 2552821 attaggtggt ttgtgaaaat ctccttctta ttttacaaaa aaaatgaaaa aagaaaaagc 2552881 tgacactctc gtttctttat aaaaataaaa ggagcataag ctaaaaagcg cataatggct 2552941 ttctagcttc agctcccttt gtgttcgcaa tttactttat agtactttcg cttgcgcctg 2553001 tttaatttgc acaggcccca ttcctcttgg tatttcaatg ttttctcttg tatcagcatg 2553061 taatgcctct gcaatgtaat cagcagcgac attaggatct aagtctccac aagtataaac 2553121 atcaatgctc gcatatccgt gctcaggaaa actgtgaatc gttaagtgtg attcagaaat 2553181 aatcacaact ccgcttacgc cttgcggtgc aaatttgtga aatgcaacct cgcgcacctc 2553241 agcacctgat tttagagcag catttacaaa cgttttttca ataaaatcca tgtcattcag 2553301 cttatcaaaa tcgcatcccc atagctcgga gataacgtga cgccccattg tttccatagt 2553361 catggacccc ccttaacaag aattaaaaag tgaaattcca acaactgggt cggccattta 2553421 ccacggggga aagttagtcc ggagaggtcc taacccttta agtaattccg aaacagtctc 2553481 aagcaagaag ttcacgaaaa atagtatact gtgtttaagt ctaatttgca aggtgcgttt 2553541 tttcagaaat atgctgttaa gggttttttc tttaaaatgt gtccatgacc ttattttata 2553601 cagcagacgg atgtttcatt cgtgccgcta catggcggat tagatcaaca actctgcagg 2553661 agtagcccca ttcgttgtca taccacgcca gcacctttac tttcctgtct tccattacca 2553721 ttgttgtaag cccgtcaatg accgctgaat gcggattcgt attataatca gtcgaaacga 2553781 gcggttcatc tgagtaatca agtacaccgt acatcgacgt tttggcagcg cgtttaaatg 2553841 cctcgtttac ttcttcagcc gtaacatccg ttttcagatc aacaacgaga tcaaccaatg 2553901 agacgttcgg aacagggaca cgcaaggcga ggccgtgaag ttttcctttc agatgcggca 2553961 gcacaagcga aagcgccttt gccgctcctg ttgttgttgg aatgatggat tcaccgcaag 2554021 cccgcgcccg gcgcaaatct ttgtgcgggt tatcaatatt tttttggtca ttcgtatacg 2554081 catgaactgt agtcatcaga ccgctctcaa tgccaaactc ttcatccagc acttttacaa 2554141 caggcgcaag gcaatttgtc gtgcatgacg catttgaaat aatgacatgg cgctcagcgt 2554201 cgaattggtc ctcatttacg cccatcacaa tggtaacgtc ttcatttttt cccggagcgg 2554261 tcaaaatcac tttttttgca cctgcttcta tatggcccat cgctttatct ttagcattaa 2554321 acttccctgt tgcttcgacg actatgtcaa tatcatattc ccgccaaggc agctgttttg 2554381 gatcacggct gtttaacaaa agcactttct ttccatttac gatcaggcta tcttcaccag 2554441 ccacaacctc tttgtcgtat ctgccgtgaa ttgtgtcata ctttattaaa tgagccagcg 2554501 tttctgcgga atagctggcg ttaatggcca ctacttgaat ttgatcgtct aacatcgctt 2554561 ttctaaaaac cattcttccg attcttccaa acccgttgat cgctactttt accttcatgt 2554621 tggacacccc ttatcaatta tgccatccta atttgttact atctaaaatt agtataacac 2554681 attaaaacaa attcgccagt acatattgat aaaaatcaac gattataacg ctaatttatg 2554741 atgcatctta tgttttcttg cacagaatat caggcgtaag aaccaaaaag cagccagcgc 2554801 tccgcactga ctgccctcat gctttatgat tcctgtttta acttatcatt gagcacactt 2554861 tcttctagca cagaaaatgt atccccgtac actctgttaa tatgattcgc tccccaagca 2554921 cacagcatat ctaaaatccc ttctaagctg cggccgtatt cgctgagctc gtattccact 2554981 ttgggaggaa cttgattata tacgattcgg ttaatgacac cgtccgcttc cagctcgcgc 2555041 agctgctgag tcagcatttt ttgcgtgata ttgggcatta ggcgttttaa ttcacttgtg 2555101 cgtttttttc cgtgcgtcag atggcataaa atgacgcatt tccatttccc accgatcact 2555161 tcaagagtcg cttcaacaga aatgttatat tttttcttct ccatacaatc cattctcctc 2555221 acaggcacca aaaagtgact atagcacttc aaagtacgta cttttatttc ttaacgatat 2555281 gtttcataat cacatttgcc ggctgatttg aatctgctct tttttattta tatagcttac 2555341 tcggcagaat ttcaatcata caacacatct tacaaaggag gaacatcatg acttcagcca 2555401 ataaaagcaa tattcctgca ctactggctt tggccgtaag tgcattcgca atagggacaa 2555461 ctgaatttat cagtgtcggc cttttgccgc tcattgctga tgacctggat attcccgtca 2555521 cgacagcagg attgaccgtt tccctttatg cgctcggcgt tacatttggg gcacctatat 2555581 taacttcatt gacctcaagc atgtcacgta agacactatt gctttggatc atgtttattt 2555641 ttattgccgg taatacgatg gcagcaaccg cttcaagcat cgggatttta ctagcagcac 2555701 gtgtgatatc ggcattttcg cacggtgtgt ttatgtcgat cggttcgaca atcgcagcgg 2555761 atattgtccc ggaggataaa agggctagcg cgatttcaat tatgtttact ggcctcactg 2555821 tggcaactgt aaccggagtt ccttttggga catttatcgg ccagcagttc ggctggcgtt 2555881 tcgcctttat ggtcattatc gccgtcggaa tcattgcttt cattacaaat ggcattcttg 2555941 taccgtccaa attacgaaaa gggacgaaaa caacgatgcg ggatcaattg aagcttgtga 2556001 caaacagccg gttattgctt ttatttgtca ttacagcgct tggatacgga ggaacattcg 2556061 ttgtgttcac gtatctgtct cccctgcttc aggaagtaac aggcttcaaa gccgggactg 2556121 ttgcagtgat tctgctcgga tacggaatag ctattgctat cggcaatatg attggcggaa 2556181 agctgtcaaa ccgaaatccg attgccgctt tattctatat gtttatcgta caggcaatcg 2556241 ttctattcgt actgacattt acagccccgt atcaagcagc agggctcatt accattctct 2556301 gtatgggatt gctggccttt atgaacgtgc ccggccttca ggtgtatgtc gtcatgctgg 2556361 ctgagcgttt tgtcccgagt gcagttgacg tcgcatccgc gatgaatatc gctgccttta 2556421 atgcagggat cgcgcttggg tcataccttg gcggtgtgat caccgattca atcggattga 2556481 ttcataccgc ttggataggc ggattaatgg tggtcggtgc agtcatttta acaggctgga 2556541 gccgcttgat ggaaaaacga gatcggcagg aagcctgaca attttaaagg aggaaataaa 2556601 catgacaaca catttacaag caaaagcaac acttcataat ggggtagaaa tgccttggtt 2556661 cggcctcggc gtgttccaag tggaagaagg atctgaactg gtaaacgcag ttaaaactgc 2556721 cattgttcac gggtaccgca gtattgatac tgcagcaatc tatggaaatg aagctggagt 2556781 cggagaaggg attcgggaag gcattgaaga agcaggcatt tcaagagagg atctgtttat 2556841 cacatcgaaa gtatggaatg cggatttagg ctacgaagaa acactcgccg cgtttgaaac 2556901 aagtctgtcc aaactcggtc tggattattt ggatctatac ctcatccact ggcctgtaga 2556961 aggaaagtat aaagaagctt ggagagcgct tgaaacgctg tataaagaag gccgtatcaa 2557021 agcgattggc gtaagcaact tccaaattca ccatcttgaa gatctgatga cggcagctga 2557081 aattaagcct atgattaacc aagtggaatt tcacccgcgc ctcacacaaa aagagttgat 2557141 aagatactgc caaaatcagg gcatccagat ggaggcttgg tcacctttaa tgcagggaca 2557201 gctgctggat caccctgtat tggctgacat cgctcaaaca tataataaat ctgtcgcaca 2557261 aattattttg cgctgggatc tgcagcatgg cattataacg attcctaaat caacgaagga 2557321 acaccgcatt aaagaaaatg caagcgtatt tgactttgaa ttaacgcagg atgacatgaa 2557381 ccgaatcgat gcactgaatg aaaacttgcg cgtcggtcct gatccggaca actttgattt 2557441 ttaatggcca aaaaacaccg ttcaatatga acggtgtttt ttgtattatg cccagctgtt 2557501 catgatttca tcaagctgcc ttttggtctc ttcaagcgtg ccgctgttat caatgacttg 2557561 atctgctctt gctgtttttt cctctaaggg catttgagag cggatacggc tgactgcttc 2557621 ttcttctgtc agctgattgc gcttcatcag acgttccagt tgaagctctt ttgtcacact 2557681 gaccacaata attttatcaa ccaatgattc caatttgctt tcgaacaata gcgggatatc 2557741 caatacaaca aatgcctccc gatttgcaac ggcttcatca cggcgattga gcatttcctg 2557801 cctgactgcg ggatgaacaa ttgcatttaa agcgagacgt ttttgttcat ttgtaaatac 2557861 cagcgctcca agcttttttc tatctatatc gccatttgag agcagtatgt cttcaccgaa 2557921 ttcgtcaatg atttgccggt aggccggcat ccctttttct accgcttgtt ttgcaatgat 2557981 atctgcatct ataactgtta ttcctttttc aatcagcata ttggctaccg tgcttttgcc 2558041 gctagctatt cctcccgtta aaccaatgac taaggtcaag agatccactc ctttttacaa 2558101 tttccagagc ccaatcgtga ttaatagaag ccccggcaaa aacgccattt tatcgatcca 2558161 tttccactta gacagaaaat ggccggcatt gattccaatt gatacaaaca gcgagctcat 2558221 gattgccacg gcgatgctca tcacaatcgg cgaaaaaccg agaatggctg cgcctatacc 2558281 tgctccaaag gcatcaatcg ataaggcaaa tcccaataag accgcctcaa ttccgttgat 2558341 cacacccgat ttgtcgatat ccgcactcat gggttttctc aaaatatgaa tcacaattcc 2558401 taatgaccga acctctagat taagcagtgt tttttcatgc aataggtatt ctttatcttt 2558461 tgccggtttg aaaaattgat acagaaccca cgcaccgatt ccaaccaata tcaaaccgcc 2558521 aagcttctcc gtcacatata caggaaaaaa cttcgtgaga aagcttccga tcagcatgga 2558581 tataaacatg acagcaccgg aacagcaggc gataaccaaa atcgctttaa acggtatttt 2558641 catttttctc aatccgtacg taaatccgac tgaaaaactg tccaagctga cagccaacgc 2558701 cagcagcagt atagaaacca tttgcatatc cgtttcttcc tttctgttgg tgctcttgta 2558761 tcagatgtga aatgcccggg attcatcaca atcatatata tgggaaagtg aaaaatccgt 2558821 gtttcgaaaa tggcatcctt aatccagagt tactgatata tgcaccgaca gcttggacaa 2558881 tgaagcatta tgctactttt ttgtctggca ctttgcgcaa aaatgcgtgc ctcttcctcc 2558941 aacgacaatt ttcgaaatca tcgttccgca atttttgcat ggctcgtctt tttttccgta 2559001 cacaaaatgc tgcagctgga acattccgat ttccccttgg gagttgatat atgaacggac 2559061 tgtgcttccg cccgcatcaa tcgcctcctg cagagtgttt ttgatttcag cgtgaagggt 2559121 tttgattgtt ttatctgata attgatttgc ttttgtctcg ggatggacac ccgctctgaa 2559181 aagagcctca tccacataaa tgttcccgag tccaactacc gttttttgat ccagtagggc 2559241 agttttgaca gcgcggtttg ttttcgcaag ccggtctttt aaatacgcac ttgtaaattc 2559301 ttctgcatcc ggctccggcc ctaactgaga aagcgggagc tcgcccgctt cttctcccgg 2559361 tttaaataag tgcatggttc caaatttccg cacatccctg taccggagct gggttccatc 2559421 cgtcatcgtg aatatgacat gcacgtgttt atcgtcaggc tcctcggctt gatgaagacc 2559481 gtattttcct tccattcgaa ggtgagaaac cataacataa tgatctaaat gaaacagtaa 2559541 aaactttccc cgtcttccga tggactgtat cgtttctcct gctagttttc gcgcaaattc 2559601 ctccggttcg gcaggccgtt tgatgatatt cggccatctg atctctaccg atttgattgt 2559661 ttttcccttt acaagcccgg tcagagtgcg ccggaccgtc tcaacctctg gtaattccgg 2559721 cacatccatc acttcctatc tctgtttatt tcgcatcgta ccaagatggg cctgatgcaa 2559781 agtccacctt taacggcaca tctaatgcaa gcgcatgctc catcacttca ggaacaagct 2559841 tttcaagaat ttcaatttct tcctttggcg cctcaaaaat caattcatcg tgtacttgaa 2559901 gcagaagcct tgctttcaac tgtttttctt tcagcttggc agccatgtca atcatggctt 2559961 ttttgataat atcagcggcg cttccttgaa tcggcgtatt catggccgtc cgctccgcaa 2560021 aacttcggat attaaagttc cggctcgtca gctcagggat gtagcggcgg cgatgcataa 2560081 gcgttgttac gtatcctttt tgtttcgctt cctgtactga atcttccatg tacgctttta 2560141 cgccttggaa gctttccaga tagcggtcga taaatgctcc cgcttccttc cgggtaatgc 2560201 cgaggttctg tgacagaccg taatcgctga tcccgtaaac aatgccaaag ttgaccgctt 2560261 tcgcctggcg tctcatcgca gatgtcactt catccttagc gacatggaac acatccattg 2560321 ccgttttcgt gtgaatatcc atatcattag taaaagcttc gatcagattt tcatcctttg 2560381 aaatatgggc aagcacccgc agctcgattt gtgaataatc ggctgcaaaa atgagccagt 2560441 ctttttcaga cggcacaaaa gcttggcgaa ttttccgccc ttcctcaagc ctgatcggaa 2560501 tgttttgcag gttcggatca gtcgagctga gacggccagt ttgcgttaag gcctggttaa 2560561 atcgcgtgtg cactttatgc gaatccggtc tcgtcacctt taaaagccct tcgatatatg 2560621 ttgattgaag cttgccaatt tgtctgtact gtaaaatata gtcgacaata tcatgcttgt 2560681 cagccagctt ttcaagcaca tcggcagacg tagaatagcc tgttttcgtt ttctttacga 2560741 caggaaggcc gatcttttca aataagatga cgcctagctg tttcggagaa ttgatgttaa 2560801 acggctctcc cgcaatctca tggatttttt cttcatattc cttcagcttc gcacccagtt 2560861 cttcacccat ccgttttaaa cggtcaacat cgaccttgac gccagttgat tccatttcgc 2560921 caagaataag cgcaagaggc atttccagct cttcaaacag ttcaagctgg tcgttgtttt 2560981 ccagctcttg aacgagcttt tcccgaaggc tttgaatcgc taacgctttt cggccaaggt 2561041 gctcagacag tacgtcttct gacggcactg cccgttttgc tccttttcca taaactgatt 2561101 catcacttga aacgatatgc aggccgtaat ccttagccac actcgcaacg tcgtcatatg 2561161 aattgcccgg gttgatgata taagccgcaa ggagcgtatc aaactcggct cctttcagct 2561221 caatgccctg ccagcgcaaa gcgacaacgg cccgcttgct gtcgaagacc catttcttct 2561281 gctcgtcatt ttccacccat tctttaaaca cctcagactc aacggcaatg tctttcggaa 2561341 tgaaataagc tcccgtttca tttacgatcg aaaatccgag gatcggctct tcatgataat 2561401 tatcgccaat ctgttcaacg acaaatgcgg atggagaaac caatatatcg cttgtcacgt 2561461 ctgtgactgt tttgacatta atgtcttcca acgattgatc ctgttctgct tctgcactgt 2561521 cttctccaag ccgttcaaga agcgtgttga agccaagatc tttaaagatg gcaatgacct 2561581 gttcacgatt aaagccttga tattccaggc cggaaacaga tacctcaatc ggagcatccg 2561641 tcataattgt cgcaagctcc ttgctcatca atgcctgatc cttaaactcc tcaagctttt 2561701 ccttcaattt ctttccgctc acctcgtcaa tggactccag cagcttttca acggaatcaa 2561761 attgttttaa aagcttaatc gcagtctttt ctccgacgcc gggcacaccc ggaatattat 2561821 ctgaggaatc gcccatcaga cccttcatgt caatgatttg ttcaggcgta agcccatatt 2561881 tctctttgac atgctccggt gtgtaaaatt caacatcggt aattcccttt ctcgtaatgg 2561941 caactgtcgt tttgtccgtt gccagctggg ttaaatcctt atctcctgag aaaaccttaa 2562001 cttcaaatcc gtctttttca gccgatttgg ccagtgtgcc gataatatca tccgcttcat 2562061 attgttccag ttcatagcgg ctgatctggt aggcatccag cagctcgcgg ataaacggca 2562121 tttgttcgga aagctcaggc ggggttttct gtctgccgcc tttatattct ttaaatgtgc 2562181 cgtgacgaaa tgttgttttc ccggcatcaa acgcaaccag catgtgcgtc ggtttttcat 2562241 cctcaagcat tttcatcaaa atcatcgcaa agccgtatac agcattcgta tgaacacctt 2562301 tatcattgct taacagcggc aatgcaaaaa acgcccggta agccagactg tttccgtcta 2562361 caagcactaa tttttttcgt tccgtcattc aatttcctcc taagaagcct caggcttcca 2562421 ttcatctctt acatagtcat tagctcctct tattttaaca aagttcaatt tgaaaggaaa 2562481 atacgtgaac tataagagaa gacacaaaaa aggacgggaa cacaaatagg ttcccgccgt 2562541 caaaattggc tccttggatg aaggggttct actacatcct accagcatag gtttaacagt 2562601 gcatgaagat attgttaaac ctttgtaaac attaggcgga cttttcagcg gcccgtttca 2562661 gcgtcacggt aaagacagtt ccccgtccaa gctcgcttgt gacatcaatt ttcccttcat 2562721 gagcctctat taaatgcttg acaatcgcta ggcccagccc ggttccgccc gaatttctgc 2562781 ttctgtcttt atctacacgg taaaagcgtt caaagatgcg cggaatttct tctttctgaa 2562841 ttccgattcc agaatcggca acctcaatct gaatgtcttt ttctctgggc tttacattga 2562901 tagccacgga gcccccctca ggcgtgtagg ttaatgcatt gtttacgaga ttaagaaata 2562961 cctgtttcag cctgtacggg tcaccagata catattgagg gtctttcggg acattcaggt 2563021 gcaaggagat gcctttctca tccgccttat gcttcagaag cgtttcaatc tcaccaagca 2563081 ttttggccgg ctcaaacgtt tcgatactga gcgtgaaatt ttgctgctcg atttttgaga 2563141 gatcgagcaa atcctgaacc aaagactgaa gcctttcgct ttccttaaga ataatagaga 2563201 gaaattcaga aagcgcctct ttgtcttcca tcgccccgtc caataacgtc tccgtaaacc 2563261 cttttatgga cgtaatcggt gttttcagct catgagaaac attggccaca aaatccttcc 2563321 tcatctgctc taatttcttc gtttccgtca tgtcatggaa aacgagcaca attcctttcc 2563381 attcatcgtc cggccccata atcggaacgc cgtccacttc aaaataacgc cgttctattt 2563441 tgatcggcag tcttaacagc ttgcatttct ttgtctccgt cataaaaatg tcttcgacaa 2563501 gctggatcac ttcttcatgt tcaaatgcat cgtgataaag acggcgcagc atatgattcg 2563561 gattgatatg aaactgcttg gcgtaagacc tgtttacgag attaataaag cctcttccgt 2563621 cgatcataat cagcccggag ccaatgtttt caatgactgt cagcagccga tcccgctgca 2563681 tttcctgcgt tcgcgtcatt tccatcagat caatggcaag gctgttcatc gcatgtccta 2563741 gcttatcaga acgcctaata tagccgccgt acgtccgtgc atcgtagttg cccttagaga 2563801 gttctgtggc tacatttgtc gctgactcaa ttgacctttt ataacgtgag gtcatgctgg 2563861 aataaaaata aacaatgacg ataaatgcgg tacaaagact ggccgtcagc atcccccaca 2563921 attcgccttt taagccgtcg cttttttcag aggcggaaag cagcacatat cctgtttttt 2563981 caccttcgct tctaagtgaa agtccgtaat aaagcttgtt atctgttgtt gacagaatac 2564041 cctcatggcc agaaacaagc gcctgcacct tttgggaatc agccgatcta ccgtttgacc 2564101 catacagcac cttaccgtct gtatcgataa cggatgcgct cacatcaagc gcgccgcctg 2564161 catctttaat gattttctca tttgcttgat tattcagatt gccggcatca agaagcgaag 2564221 ccaagtattt tgcttctttt tcaatgtgtt cctctgcttt cctttgatca gatgtttcaa 2564281 aaagctgctg taaaaacagc ccgaggacac aaaacaccag aatcatacag acaacgaata 2564341 cagaaaaaag gcgcacacgg tatttattca ttcatttttg gctcctccag tttatacccc 2564401 aatcccctaa tcgttttaat gtagatcggt tttttggtat tgttttcaat tttgtcgcga 2564461 agatggctga tgtgcacatc aacaattctc gtatctccgg caaaatcata attccagact 2564521 gcgctcagca gcaggtctct tgtcagaact ctgcctttat gtctgcctaa atagagcagc 2564581 agttcgaatt ctttcggtgt cagttcaagc tgactttctt taaagtacgc ttcataatga 2564641 tcaggcagga ttttcagatc gccgattacg atctggcctt ccatttcatc gttcttcatc 2564701 tcactagagg gcgcagctat ttccgaacgc cttaaaatcg ctttgactct cgcatttact 2564761 tcccttggac tgaacggctt ggtcatataa tcatcagcac cgagctccag ccctaatact 2564821 ttgtcgaatt cctcatcctt cgctgtcagc attaaaatgg gaaacatcag tttttgctgt 2564881 ctcagctgct tgcatacttc gattccgtcc aattttggaa gcatcacatc aagcacaatc 2564941 aaatcaggtt tctctgtttc cgcttttttg agtgcttctt ccccatccga ggcggtaatg 2565001 acatcatagc ctgaccgttc caaattgtac tgtaaaagag taacaataga ttcttcatca 2565061 tccacaacta aaattttctt gttcatgctg tgcctccagt attataattc cccgacatcc 2565121 tatttctcta ttttatgtca tcttaacatg tttcatgatt ttattttagc gaaagcagga 2565181 cattccgaca attcgccttt tacatcattt ttaaaagaaa taaagacgtt tatgatagcg 2565241 ctttcattta tagtaaaaag agaaaggctg tattaagcaa gcctttctct ctttttatta 2565301 ggataatact ttcatgacat ttttgacaga ttcaactgat ttattcagct gcgctctttc 2565361 atagtctgtc agttcaagtt caatgatttg ctcaagaccg ttgccgccta caattgtagg 2565421 aacaccaagg tagatgcctt catagccgta ttccccttca agataagcaa ttgtaggaag 2565481 gacgcggcgc tgatctttca agatcgcttc gaccatttct gtcagagaag ccgcaggcgc 2565541 ataatacgcg cttccgtttc caagaagatt cacgatttcg cctccgcctt ttctagtgcg 2565601 ctccacaatt gcgtcaatcc gttctttcgg aataagagtt tcaagcggga taccgccagc 2565661 ataagaataa cgcacaagcg gaaccatatc gtcaccgtgt ccgccgagta cgaaaccagt 2565721 cacatctttc actgacaggt ttaattcctc tgccacaaat gttctgaatc ttgccgtatc 2565781 aagcacacct gactggccga ttacacgctc tttagggaag cctgattctt tgtacaccgc 2565841 gtatgtcatt gcatcaacag gatttgtcag caccacaata atagagtcag gagaatattt 2565901 cacgatttcc tgcgtaacgc ttctcataat cttttcgttt gtagagacca gatcatctct 2565961 gctcatacca ggttttcttg cgataccggc tgtaatgaca acaatgtcag agccggctgt 2566021 atcctcgtaa ttggatgttc ccgtaatttt tgcgtcaaag ccttgaaccg ggcttgcttc 2566081 aagcatatca agcgcttttc cctttgtcgg gttctccaat tgcggaatgt caacaagaac 2566141 aacgtctgcc agctcttttt gagcgattaa aaatgcagtt gtagctccgg taaaacctgc 2566201 tccgataaca gaaacttttt tacgagtatt tcccatgtct ctcttctcct ttatggctag 2566261 ttttaggctt tttccttgct tagtccatgt ttttgatcag ttcttctccg aactctgaac 2566321 atttcacttc agtcgccccg tccattaatc tggcaaaatc gtaagttacg actttagaag 2566381 cgattgtttt ttccatagat ttgataacca aatcagccgc ttcgttccat cctaaatgct 2566441 caagaagcag aacgcctgaa agaataactg aagatgggtt tactttatca aggcctgcat 2566501 atttaggagc cgttccgtgc gtcgcctcga aaatcgcatg tcctgtttcg tagttgatgt 2566561 tcgctccagg agcaatgccg attccgccga cttgcgcagc aagagcatca gaaatgtaat 2566621 ctccgttcaa gttcattgtc gcaacgacat caaactcgtt tggacgcgtt aagatctgct 2566681 gaaggaaaat gtcagcaatg ctgtctttga taatgatttt tcctgctgct tccgcttcgc 2566741 tttgcgcttt gttggcagcg tcttttcctt gttcttcagc aatgcggtca tattgagccc 2566801 atgtgaagac tttatctccg tattcttttt cagcaagttc atagccccag tttttgaagg 2566861 cgccttctgt gaacttcatg atgtttcctt tgtgaacaag tgttacagat ttgcggccat 2566921 gctcgatcgc ataatcaatg gcagctctga ccaagcggct tgttccttct tctgaaacag 2566981 gcttaatgcc gatacctgat gtctcaggga aacggatttt attgacgttt aactcatttt 2567041 gaaggaagct gataagcttt tgcacttctt cagagccttt tgcatactcg atgcctgcgt 2567101 aaatatcttc tgtattttca cggaagatga ccatatcagt atcttcaggg cgttttaccg 2567161 gtgacggcac tccagtaaag tatcttacag gtcttaagca gacgaatagg tcaagctctt 2567221 gtctgagcgc tacgttcaaa gaacggatac cgccgccgac aggtgtcgtt aacgggcctt 2567281 taatcgcgat gaaatattcg cggatcacat ctaatgtttc agcagggagc cactcacctg 2567341 ttttattata agccttttct ccggcgtaaa cttctttcca tgtaattttc ttttcgcctt 2567401 tgtatgcttt ttctactgct gcttccaaaa ccttcgaagc cgcgttccaa atatcaggac 2567461 cggttccgtc tccttcgata aatgggataa tcgggttgtt tggtacgttt aatactccgt 2567521 tagagactgt aattttttca ccttgtgcca caataaaaac ctcccagtat gtaattcata 2567581 tttagaaaac attttatttt tcttatatag aaaataaaat gatttttcct aacattcaat 2567641 ttaaagtgta acccaatttt gatgtctgaa caagaggcta acctcattga cgcaagccag 2567701 cctccaatgg ttctttaggc tctttcttca atcggaacga atttttgttt gtcagggcct 2567761 gtgtaatctg cccgcgggcg gatcagacgg ttgttgtcat actgctcaag aatatgagcg 2567821 agccagccgg acattctgct tacagcaaaa atcggtgtaa acaaatcatg gtcaataccg 2567881 aggctgtgat atacagaagc cgaatagaaa tcaacgttag gcggaagctt tttctctgat 2567941 gtgacgatgt cttctatacg aatcgacatc tcataccatt tgctttcgcc tgtcaggttg 2568001 gtcaggcgct tgctcatttc tttcagatgc ttcgcgcgcg gatcaccatg cttatacaca 2568061 cggtggccga atcccatgat tttttctttc ttttcaagtt tagcgcggat gtacggctca 2568121 gcgttttcca cttcaccgat ttctgtcagc attttcataa cgccttcatt cgctccgccg 2568181 tgaagaggcc ctttcagcgc gccgattgct gcagtaatgc ctgaatagat gtcagaaagt 2568241 gttgcgacgc agaccctcgc tgtgaacgtt gacgcgttca gctcatggtc agcatgtaaa 2568301 atcaatgctt tgttgaaggc ttcaacttca attggtgaag gctcttcacc gtttaatgtg 2568361 taaagaaaat tctccgcaat accgtaatct tctctcggtt caacaggctc aagacccttg 2568421 cgaattctgg aaaacgctgc aaccaggcca ggcacctttg cctgaaggcg gatcgccttt 2568481 ctgtagttgg cttccgggtt catggtatca gcctcgctgt caagcaggcc tagtaatgaa 2568541 attgctgtcc gaagagcagc catgggatga acattttcga gggaataaga tttgaagtgc 2568601 tcaataattt cttgcggaac ggcagcttcc tttgcaagct gctgctttaa ctcttcaagc 2568661 tcttttttgt ttggcagcct tagatgccaa agcaagtaga tgatttcttc aaaacttgca 2568721 ttctctgtca aatcatcgat atcatacccc acatatgtaa gggtatcatc aataatagaa 2568781 ctaacagatg atgttgttgc tacaacccct tcaagaccgc gtgtcgctgt catatataac 2568841 atctcctttt caataaattt cccctttaag agtgttgtaa aaacatgagg cttacttaaa 2568901 aagcacgatg caagtatttc tctcccccaa aaagaaaatg cttacatttt actggctgct 2568961 ggaactaaaa ccctttgctt ttgaaagaac ataacaaatt tttataagct tatttaagtt 2569021 taagcctatt ctcattataa acaataatca gacatttgtt aaatgtttac ctataatttt 2569081 ttttttccat tctgtgattt ccccgaaaaa acgcctttat ttgcgggttt ttgcataaaa 2569141 aaaagcggct ttaaggccgc ttttttttat gaagtgaaca gttttacgat ctgcatggct 2569201 aaataagcaa tccccgctcc gatcagcggc cccaccgcaa ctcctccaaa aagcgcgact 2569261 gcaagaatgg tcccgatcac gagagcagtt gtaatatgcg gatcattttc aagcagggtc 2569321 aggccgtttt ttgcaatcag cgccactgcg atccccgctc caagggcgat ccatgcgtag 2569381 gaagaccgca ttgcttctcc aagctgctta aatccgattt ctcccgtggc aatcgggaca 2569441 agaacggcga tggtaataat ggtcacaccc cagttaatgc cttttgactg gatggtcgga 2569501 aataatttct gatcaagccc aacgattttg atgatcaaaa ggacggatac agcaaagagc 2569561 aatgattggt tttttgcgat aagtgcgata gccaagagta aaattaaaaa taaattcgct 2569621 tgtgtaaaca catgccatcc ctcctttaag atgaatgtat tcatattcag ccgcagcgtg 2569681 aatacatata aaaaatagga catgctgacg agaggaggac cgtttttgtg aatcaatctt 2569741 atatcactat ttttttcaga accctctttg tcatatcaat gaccgcaggg tcgatagctg 2569801 cggcctatta ttcgtttccg ttaacttatc cgttcctgat cgcccttatt ctatcttcag 2569861 tgattcatcc tgttgtcgat tatttggaca aagtgacagg attcccccga acgataaatg 2569921 ttctgggcgt tcttgctttt tttctgctcg cagccttcgg cgtgctcacc attctggtag 2569981 ccgaaatcgt aacgggaaca gcctatctag caaaaacgct gcctccgcat atcagcacgt 2570041 ttatttcata ttgcgaaaaa ttgtttacca ctcatattca gccgctctat aacgagttaa 2570101 ctcttttgtt tcaagaattg gaaacgaacc agcaggcttc catcgtcact catatccaga 2570161 cactcggtga ttctgccgct aaaaatgccg ggctcctgct gtcccacatt ctagagatga 2570221 tcccgagatt tttcgctctt cttcccaata cggcggcggt tctgattttt tctcttctgg 2570281 caaccttttt tatgacaaag gattggcata agctgaaagc catgcttgtt ttaattctgc 2570341 cggatcgtgt gacagctaac agcaaagcaa tcagcagcga attaaaaaaa gcaatgactg 2570401 gttttatcaa agcacaagcc gtcctcgttt tcatcacgat ggtgattgta tttatcggcc 2570461 tttctctctt aaaggttgaa cacgccgcaa caattgcttt tttaatcggg cttgtagatc 2570521 ttctccctta cttaggtgcc ggctccgtat ttgtgccctg gattttgtat ttatcgatta 2570581 cgggccagct gccccaagca atcggaattg gtatcctgta cctcgtcgtt cttattcagc 2570641 ggcagctgac agagcccaag atactaagta aatctatcgg gatcgatccg ctggcaacac 2570701 tcatcgccct gtttgccggc tttaaattat tcgggttttt aggactgatt gcgggaccgg 2570761 ctgtactcgt catcatccaa gctttcatca caacaggcgc attaaaagaa atatggtcct 2570821 atatcaccgt tcagcaaaaa taaaacggca gccgtttttt catggctgcc gttttttatt 2570881 tgatgatgat ccgcttattc ttcgacattc ctctcagcca tttgaacaga atcggcttac 2570941 accagccgcg ggtaaacggg ataagaagac aggcgccggc caaatctgat aaaaagcccg 2571001 gaagcatcag caatagaccg ccaatgaaaa tgcacagacc gtcagcaatc gcttctcccg 2571061 gcattttgcc atattgaaga tcacgctgaa ccttataata cacttcggtt ccttgttttt 2571121 ttgcagctgc tgcgccgata atgccagtca gaatcatgaa tagaactgtc ggcaaaatac 2571181 caatcagatt tcctaaaaat aggaatatac cgatttctat tgccggaaac acaataaaaa 2571241 gcaaaaacaa aaatctcata tccaagcccc ccacacgtgt aacacgttct gttcaacaaa 2571301 aggcatgata aagagaaaag gaagggattc cccttccatt ttcacctgta attaaagaac 2571361 gctcgcacgg ccttgataga ctgcgcctct ggaagcgtca actgtaatat cctggccatc 2571421 tgtcaaaata gatgtcgcat tttccagacc cacgataacc gggatgccaa ggcttaatcc 2571481 gactaccgca gcatggctag tcaaaccgcc ttcttctgta ataagagcag acgctttttc 2571541 aagggatgca atcatatcac ggtcagtgct tttggtaaca agtaccgcac cgtcagtcat 2571601 tttttgctca gcttcttttg cattttgtgc aacgacaacc ggaccgtaag ctgatttgcg 2571661 tccaatgcct tggcctttag cgatgatatc gccgacagta tgaaccttca ttaagttcgt 2571721 agtgccggac tcaccgacag tgccagctgt aataacgata agatcgccgt gttttacaat 2571781 tccgctgttc aatgattttt ggacagcatc ctcaagcatc tcatctgttg agctcgcatt 2571841 ttggccgctt tccgcgaata cgccagatac gagggcaagc tttctggaaa tagagtcatt 2571901 tacagtaacc gcaacaatcg gagcctgcgg acggtatttt gcaatcatac gtgctgtatg 2571961 gccgctttct gtcggcgtta cgatcgcagc agcattcagg ttaatcgccg tatgtgcgac 2572021 agattgtcca attgcgtctg taattgtcat gcccacttgg tctctgcgtt ttgagagaat 2572081 ttctttataa tttaatgctt cttcagaacg ggacgcgatg ttatgcattg tttgaactgc 2572141 ttcaaccggg taacttccgg cagcagtttc accagaaagc atgatcgcat ctgttccgtc 2572201 gaagatcgcg tttgcaacgt cacttgcttc cgcacgagtc ggacgcgggt tgcgctgcat 2572261 gctgtcaagc atttgtgtcg ctgtaataac aggtttgccc agcgcgttgc attttttgat 2572321 cagttctttt tgcacaagcg gcacttcttc agctggaatt tccacaccta agtctccgcg 2572381 tgcaaccatt aagccgtcag acacttcgag aatcgcatcg atgttgtcaa cgccctcttg 2572441 gttttcgatt ttagggatga tttgaatatc ctgagcgttg tgctcttcaa gaagctcacg 2572501 gatttcgagc acatccgtag aacgtcgaat gaaagatggt gcgatgaagt ctactccttg 2572561 ctcaataccg aaaacgatgt ctcgcgcatc cttttcagta atccccggaa gattgacact 2572621 tacgcccggt acgttaacac cttttttatt tttgagtgtt ccgttgttta atacttttgt 2572681 tttgatttcg cgtttagcgg catctacatc aagtacctca agaccgataa ggccgtcatc 2572741 taacagaatc gttgaacctt gttcaacgtc atggactaaa ccttcatatg tcactgaaat 2572801 tttatctgtt gttcctacaa cctcgtccat tgaaataatg agctctttgc ctgtttcaag 2572861 ctcaataccg ccgttttcca ttgtatgtgt gcggatttca ggaccttttg tatcaagcag 2572921 aattccaacg ttcttgccaa gttttttact tgcttcgcgg atatttttaa ttcttgcacc 2572981 gtgctcctca aaatctccgt gagaaaagtt taatcgagcc acgttcattc ctgactccat 2573041 taatttcgta agcatttcaa tactttcact tgccggaccg atggtacaaa caattttagt 2573101 ttttctcatt tggttcactt ccttctgaaa tcttcagcct tcagctgtac attagataga 2573161 cagttctttt gaaagctgat acatgttttg ctcaactgtg tgttttgtct caagtatttc 2573221 tataatatca tggtctacaa gcttattgtt ttgtatacct acacagcgtc cgccttttcc 2573281 ttcaagcagc agttcaactg catatgcgcc gagacggctt gccaacacac ggtcagcagc 2573341 actcggagaa cctccgcgct ggatatggcc caatacagat accctagttt caagatttgt 2573401 ttcttcttca atgcgtttcc cgaattcaac accgctgcct acaccttcgg caacaataat 2573461 aatactgtgc ttcttgccgc gttcgtggcc gcgttttaag cgggcaatga tttcgtgcat 2573521 gtcatagtct gcctcaggga ttaagatcga ttctgcgccc cctgcaagac cggcccacaa 2573581 tgcgatatcg ccggcatgac ggcccattac ttcgattaca tatgtacgtt catgagaagt 2573641 cgctgtatcg cgaatcttat caattgcgtc aattactgta tttaaagctg tatcgaaacc 2573701 gattgtaaaa tcagtgcccg gaatgtcatt atcaattgta cccggtacac ctacacatgg 2573761 aaacccgtgt tccgttaatt ttttcgcacc catataggaa ccgtctccac cgataacaac 2573821 aaggccttca ataccaagct tcttcaagtt tgctatccct ttttcacggc cttcaactgt 2573881 tttgaattca ggacatctcg ccgtataaag cttagtccct ccacgatgta taatatcgcc 2573941 tactgatccg agttcaagct tttcaatctt tccgctgatc aatcccgcgt atccgttgta 2574001 aataccgtaa acttcaacgt catgatagat cgcttttctg actactgcgc gaactgctgc 2574061 gttcattccc ggggaatccc cgccgctcgt taatacccct attcgtttca ttctccattc 2574121 acctcagcaa catatatgat taaacataac atgatcattg ccctaaaaac aatgaaaagg 2574181 gatctccatc ctccctatga aaccttacct attatacaat taaataaatt gtttttaaat 2574241 aaaatttaag gaatgtcaca aaaaataaac gtgagccaaa ggcttcacgt ttatttagtt 2574301 taccccgata tattgatctt caaccgagac tttgccaatt gctttatatt tttcataacg 2574361 ctgctgaact aattcttctt cgctcagctt cagtaaagtt tttaacgatt gtttaagggt 2574421 ttcgtccata tagcttgcct gcagcttcac atcatggtgc gctccgcctt ttacttcttt 2574481 aatcatatga tctataatac ctaattcttt taaatccggc gcagtgattt tcattgtttc 2574541 tgctgctttt ttagcaagac tggagtcctt ccataaaagt gccgcggcac cttccggaga 2574601 aataacagaa taagtagagt tttccagcat atgcaagtga ttgcctacac ccagaccaag 2574661 ggctccgccg cttccgcctt caccaatgac gatgcagata acaggcactc gaaggccggc 2574721 catctcaaac aggtttttgg caatagcttc actttgtcct ctttcttcag ctgctcgtcc 2574781 agggtatgcc cccttcgtat caataaaaca gataattggt ctgttaaatt tgtcagcctg 2574841 tttcatcaga cgaagcgctt ttctgtagcc ttctggatgc ggcatcccaa aattgcggac 2574901 taggttttcc ttcgtgtctt tgccgcgctg atgcccgatt accgttacag ggaggccgtg 2574961 gaacttcgca atcccgccga caatggcttc atcgtccccg tacgctctgt ctccgtgaca 2575021 ttcaaaaaag tcggtaaaca ggtgttcgat ataatcaaga gttgtcggac ggtccgccag 2575081 acgcgcgatt tgaacccggt cccacggctt caaatttttg taaatatcat cctgaagctt 2575141 agcgagacgg tcttcgagcc gttcgatttc cgcacttaga tccatatcgg aatcttgggt 2575201 gaattttttt agttcggcga ttttggtttg cagttcaatc accggttttt caaattctaa 2575261 tcttggagcc actcaatgtc acctcctgtt tgatgcatat ccagcagatt ttctaacgtt 2575321 tttttcatat cgtcgcgatg aataaccgca tcaagctgtc catgttttaa taaaaactca 2575381 gccgtttgga agtcctcagg cagtttttct cctattgtct gttcaataat ccgtcttccg 2575441 gcaaaaccga tcagcgcgcc aggctcagcg aaattgtaat cgccaaggga tgcaaagctt 2575501 gctgatacgc ccccggtagt cggatgcgtc attactgaaa taataagacc ctgttcttca 2575561 ctgaacagtt ttaacgcaga gcttgtcttt gccatctgca tcaaacttaa tacgccttcc 2575621 tgcattctag caccgcctga agccgtaaaa ataataaacg gaactttatc agcttttgct 2575681 ttttcaatcg caagcgtgat tttttcaccg acgactgaac ccatgctgcc cattctgaat 2575741 gaagagtcca tgacggcgac aacagccggg tgtccgccga tggtgccctt gcctgtcaca 2575801 acagcctcgt ttaaggatgt tttctcgcga tctttttcaa gcttttccag atatcccggg 2575861 aaaccaagcg gattttccga gagcattccc tgattaaatt cctcaaagga ttgttcatcc 2575921 atcaagcttt cgatacgctg ttttgcgttc attgggaaat gataatcgca gttcatgcat 2575981 acccgcatat ttttatccaa ctctttagtg agcatgattt ttttacactt aggacatttt 2576041 gtcataatgc cttccggaac atcgtgcttc gcttgatcag acggtacgga agcatacttt 2576101 ttctttttcg tgaatatatc ctttaacaaa tgattacctc ccttttgtga agggttctct 2576161 tcaccgcatg tcatcaaaca gatagacttg ctaataactt taccgaaact attgtacttt 2576221 ttttgtcaaa cgctgtcatc ctcaattcga caacttttta ttcgatgacg tgctcggaaa 2576281 ggcttgtatg aaatcagata aggtgttgaa acgacaaggt tgacagcgca ttcaaaaata 2576341 atgttaaacc cggctgaaat ttttttaagg ctaaccccct aaaaaaattt cagccgtcag 2576401 tttaacttga gaacagcgcg ccggtctccg ccaacgcgct gccatttttg gaatgaatta 2576461 aaattattca ccaataatcg taagttttct tgttttttct gcgacttcct cagggtcaac 2576521 agtgattctt gcaacacctg tttccatcgc agcttttgcc acagccttcg caacagcagg 2576581 cgcaacacgt ttatcaaacg gtgcagggat gacatagtct gcgctaagct catcttctga 2576641 aaccagtgaa gcaatggctt caaccgctgc gattttcatt tcctcgttaa tatgagtggc 2576701 acgcacatca agcgctccgc ggaaaatacc agggaatgca agaacattgt ttacttggtt 2576761 cgggaagtca gaacggccag ttccgacaac gcttgctccg gcttcacgcg catcttccgg 2576821 catgatttcc ggatttggat ttgccattgc aaagataatc ggatcttttg ccatgctttg 2576881 aaccatttct tttgttaacg cgcctgctac agagacaccg ataaatacgt cagcatcaac 2576941 gataacatct ttcagagaac cgtctttgcg atcttggttc gtgaacttcg ccacttcatt 2577001 tttgacatcg ttcatgccgt tcgggcgccc ttcataaatg gcccctttgg aatcgcacat 2577061 cacaatgtcg cgaacgccat aatgatgaag aagcttgata atcgcaatgc cagccgcacc 2577121 cgcgccgttt gcgacaactt taatggatga catggatttt ccagacagtt tcagcgcgtt 2577181 cacaagacct gctacggtta caatggcagt accgtgctga tcatcatgga aaaccgggat 2577241 gtttgtttct tttttgaggc gctcttcaat gataaagcag tttggcgctg caatatcttc 2577301 aaggttgacg ccgccaaatg tcggttccag caattttaca gtttcaacga ttttatcaac 2577361 atcgtttgtg tttaaagcaa tcgggaacgc atctacgccc gcaaagcttt tgaaaagaac 2577421 tgctttccct tccataacag gaagcgccgc ttcagggccg atgtttccaa ggccaagcac 2577481 agctgtaccg tcagttacaa ctgctaccat gttccccttc attgtataat catatacttt 2577541 gttaatgtct tcatgaatat ccttacacgg ttctgcaaca cccggagaat acgcgaggct 2577601 taaatctttc gcatttctga cctctacttt tgatttagac tccagtttcc cctggttgac 2577661 tttatgcagg tgtaatgctt cttctcttaa tgacattctc ctaaacactc cttatggata 2577721 ttttttgatt cgtatactgc tgcgttgatt gctgcattct gcggagtaaa tctatctgaa 2577781 tatttaaaca ggatcacata attgctccaa ttgtataaca aaaagcgaat cgttaccact 2577841 gttttaaaac gacgtttttt tgacccaaca gctcttttaa gcgatataac acctggtgat 2577901 ctgcattgat atggaacgac tcaggtagct taatcgtctg tttttgcctt tcataataga 2577961 gataaacgcc tgtttcccct ttatgctcca gcaaaatgcg cttaatcttt gccaggatct 2578021 cctggctgtg ctgactgctt tctattttta tataaaccga tggcgctttt tctgcatcca 2578081 tatcttctaa taattctgcc cgggacatga tgaattggat cttatcttgt ctaacttcac 2578141 atttccccgc agtgaacaaa agagcgcctt ctcttaaaac gggagaaagc tgtctgaatt 2578201 gttcagggaa gactacggct tccatctcgc cggtttcatc actgagcgtt aaaaacgcca 2578261 tgttttgacc tgttttcgtc cgaatcgttt tgatcttcga cagcagaacg cctagtgaaa 2578321 gctgcctttt gactgcccgc tgagcctgca gaatggagac tgctccttgc gcagtgagct 2578381 gttttcggaa ggcggagagg ggatgatttg aaaaataaat gccaagcgtt tccttttcaa 2578441 acgcaagtaa atccaccaga ggaagctcct ccgtctccac atacttcggc ttaattgaaa 2578501 acgattcatc taaaaacaat cccatttggt catcgtccgc ggcgaatagc tcagcatgtt 2578561 ccaaagcaac atcaatggat gcgagcagcg tggcccggtt ttggccgaat tcgtccatcg 2578621 caccagaaaa gataagtgct tcaagcattt tgcgatttac gctttttgac ggcacgcgaa 2578681 agcagaaatc gaaaagatct tcaaatggtt tctcttttct tgctttatat atatctttga 2578741 ctgctgagac gcctacactt tttatcgcgc ggaggctgta tctgacagat ccgttttcaa 2578801 ctgtaaacgg aaaactgctt ttattcactg acggaggaag gatacgaatc ccgctcccct 2578861 ttgcttcgta aagatattga gagattttat cctcattgcc aatgacgctt gtcagcaatc 2578921 cgcacataaa atataacgga taatgagctt tcaaatacgc aagctggcac ccgatcatgc 2578981 tgtatgccac cgcatggctt ctgttaaagc catagtttgc gaatttgacg attaaatcgt 2579041 agacctcatt tgcagtgtct acagaatact ccttttttaa gcacccttca acaaaatggc 2579101 ttcgctctct gtccaggatt tcttttttct ttttgctgac cgcccttctc aataggtccg 2579161 cttcgcctaa agaaaacccc gccatacggg aagcaatcat cataatttgt tcctgataca 2579221 caatgacgcc atatgtatct tccaaaatgc tccttaaatc ttcatgagga tagtgaacag 2579281 gcgcccgacc gtgtttacgg tcgataaata acggaatatt ttccatcgga cccggccggt 2579341 acagtgcatt gaccgccaca atatcttcta ggcccgaagg tttcagccgt ttcaagacgc 2579401 ttctcatccc tgcagattca agctggaaaa tgcctgtcgt atcccctttt gacagcaagg 2579461 agaacgtttt gtcatcgctg taggaaatac ttgaaaggtc tattttaata ttttcttctt 2579521 tttcaatcat tgaagtgatg gattcaataa gtgtcagatt cctcaaacct aagaaatcca 2579581 tttttaaaag gcccaagtct tcaagatggt ccatcgcgta ttgcgttaaa tagatccctt 2579641 catgcccttc ttgaagcgga acaacatctg ttaacggttc ttcactcagg acaacgcccg 2579701 ctgcgtgggt tgatgcatgc cttggcagcc cttctatttt ccgggcaatt gaatagactt 2579761 gctgaagcag gcttgactcc cgaagccgct tatccagctg cggtgactgc tgtctcgctt 2579821 catccagcgt cattcccggt cttgaaggaa tgagttttgc aagctgatct gcctccttcg 2579881 ggctgacgcc gaatactctg ccgacgtccc ggagcgccgc ctttgccgca agtgttccaa 2579941 aggtgataat ctgtgcgacg tgcattgcac cgtatttctg ctgaacatat tgaatgactt 2580001 catcccttct agtatcggga aagtcaatat caatatccgg catgctgacg cgttcgggat 2580061 ttaaaaatct ttcaaacaga aggtgatgct taatcgggtc aacatctgtg atatacagca 2580121 catatgccac aagagaaccc gccgcagaac cccttcccgg tcctgtaaca atcccttttt 2580181 catgggcgtg cttcataaaa tcccacacga tcagaaagta atcgctgaac ttcatccgct 2580241 tgatgacatc aagctcatat tgaagacggc gaaggtatcg ttcatcaggc ttgccgaaac 2580301 ggctgcggag tccctccata cagatatccg ttaaataatc atcagcggac gttccgtctg 2580361 gggtcggaaa agacggtaga cgggtctgcc cgagactgac gtcaacccgg cattgttccg 2580421 cgatctctac agaagcttgc agtgcctcgg gatgctctcg ataaatgttt tgcatttctt 2580481 cgagtggttt caaatcgaga tcaggcaaat cttcagcggg tgcatccgtc agtttttccc 2580541 ccgctttaat cgctttcaaa caacggtagg cagccttatc ttccttcctt atgtaatgca 2580601 catcgcctgt ggccgtaaca gggatacccg tttcttctga cagctttaga atctgctcag 2580661 acaagacttg attcccttta aaaggctgat aggagaaata aaaagctccc tttccgaata 2580721 tagactgaaa ttccagcgag gcttgagcag cctgttcgaa cagccctcct tcaagaagcg 2580781 tttcaatata tcctttttcg ccgggcgtta ttgcgataat cccttctcga taactgtgaa 2580841 gccatttcgg cttcagtccg ccttttgatt tagattgcag aacgctgctg attttcagca 2580901 ggttttgata gcctgtattc gattttgcca gcaggacgag cgggtatgct tcaagctcgc 2580961 tgtcatctgt aaaaacagaa gccgtcaaac cgattattgg gttgatccct ctcgccttgc 2581021 aagctttata aaattgaata gctccgtaca tgacatgatc atctgtcagc gccaaagacg 2581081 catatccgag cctgtcagct tcactgacga gttcttccac agccgcggcg ctgtttagca 2581141 ggctataccc gctatgcact tgcaggtgaa caaaagacat gctatcacct ctttctcatt 2581201 acgatccatt tcttccttca ttataaggcc ggtttccaaa agaaacaaat gttctttttt 2581261 gactcatcat catacttgtc ctgaaagctc aatatgatat aaaaggtgag gtgataaaga 2581321 tggatcagga agcaggattt atggtgaatt ttatcaatag ctacttcatt gcgttagggg 2581381 tgctgatcgg gggcgcactc atcggagggc tcggagcata cttggcaggc gaacccccgc 2581441 ttacagccat tacaaagctt gccaaccggt taaaaatatg ggcgcttgtc gcagctatcg 2581501 gaggcacctt tgatgcggta tacagctttg aacgcggcat actcgaaggc aatacgagag 2581561 atatctttaa acagcttctt ttaattattt cggccatggg gggcgcgcaa agcggctggc 2581621 ttattatatc atggctgacc caggagcatc tttcttcatg agggtccccc agcattacaa 2581681 aaaaccggga tggcagcgtt ttttcgcggg aatgatgtgc ggagccgtaa tcagctggtt 2581741 ctttttcctg tttacttacg gaacattcca agaggagcag gtcagcctca tcgaaaagca 2581801 aaaagagcat gtaaaagact tgaacaatca aatttcgatc tatcaggaag acctccataa 2581861 actgaatgaa gataataaaa gaaaactgct gattcaaagc gtcagcgtca aattgctgaa 2581921 tggggataaa tataaaatat cacagccgga taaaacgaaa ttcgaggagc atgtaaagga 2581981 tgatatttca gaggtgatta caaaagacat agagagcgtc tatcaaacaa aggatctctt 2582041 gaagcggaca attgaaaata aagtctatat gatcaatgaa aaaaaatacg aggcaaccgt 2582101 cagagaattg attatttata cgaggctgac agtggaactt gaaatttctt tcgccacata 2582161 attatggatt ttttttaaat tctccaaact tctgtcgctt tttcccattc ttttttataa 2582221 actatatgtg aggcttaatg gcgaaaggaa ggaggaaggg aaatggaggt ttacagtgac 2582281 cgtcagttag caaaagatca agcagcccgt ctcagacaag gtttttctgc atatgccgaa 2582341 acaaactcac tcgcttccct catcaaaaaa gaacttcaat cacacaatct ccaagtctac 2582401 gaggacctta ctgatttcgg ctgctggttc atccccgtca cagatgaaca ctaagagaga 2582461 gggtctcccc tctactcgtg ttctttacat aatgtttcca gatcagctaa aatacgatca 2582521 gcttcatccc agctgtaaat agaggcgcct gaagctaacg gatgccctcc gccgttatat 2582581 ttccgggcaa gtccgttaat gacaggcccc ttcgaacgga atctgactct gatttgatcg 2582641 tcttcttcta cgaaaaacac ccaggcgcga atacctgaga tattgccaag cgtcccgaca 2582701 agctgcgacg cttcagaagc cgttgtgccg aatttttcaa gcgtatcctt tttgatgaaa 2582761 acagaagccg ccccgttttc ggacaaagac acattttgaa agataaagcc gttaagcttc 2582821 accacattca gttttgtttc atacaattga ttaaataact ctgaggaaga gaatggatac 2582881 tgaatgagct cgcctgcata ttttagtgtt ttttccgtgg tattcggaaa taaaaagcgt 2582941 ccggtatctc caacaatgcc ggcgtagatc agctctgccg ctttcgtatt cagcttccag 2583001 ccgtgctctt ttccttctaa atacagctcg taaatcattt cacttactga gctggcgctt 2583061 gtatcgaccc agagaaggtc accgtatgga tcttcgttcg gatggtggtc gattttcatt 2583121 agtttggcgc ctgaaggata acgctgatcg tcgattcttt cctgatttgc cgtatcgcag 2583181 acaatgacaa gtgcgccttc atatgtttca ttgtccacct catcaaggga atataagaaa 2583241 gagagggacg gttcaggcgt gccgaccgca aaaatatttt tttcaggata tgtttcacgc 2583301 aggatttccg taagcccaca ctgtgatccg taggcatccg gatcaggacg cacatgtcta 2583361 tgtaagataa tcgtgtcata taatgatatg gttctgatca attctgtttt catttgatac 2583421 tcctttattg tttttattca ttaaatcaca ttctctgccg acggaaaaga aaaataacgt 2583481 caaaaccaag cccgtttttg tataaaatgg ggttgtaaac ttttacgatg gaggatttca 2583541 tttatgctgg ttcttgtttt tttgattggg ctttcagcct gcttttatgt gtactataaa 2583601 gtaaaaggcg tacgggcaaa gccatctttg gcaaaagaaa tatgttcagc aaaatcaagc 2583661 atggccttag ggtcactagt cctgttctac gggcttaacc aaatgatatt attccattca 2583721 gtattaacgt tagtaatcgg cggtatcttt atcgtcatag gagcaggaag cgcttgggca 2583781 ggttataaag ccttcaggca ttacaatccc cttcacgcca aagaagctga aagagatcac 2583841 gcgtaagggg cgcctgaacg tcccttagct tctttccatc agctgaacca tcagcatcgc 2583901 tttagacacg atatgacctt ggctgtgcac ttccacttcc attttcccaa actttctgcc 2583961 ggcctccaag atgcgaggtt tgacttcgat gactgattcc atctgcacag gcttcaaaaa 2584021 gaagatggtg atgctctcta tgacgagttc gccgcgtttt ttcgagcgca aaaatcggtt 2584081 tgccgcttgc gtcaaaatgg tcgtaaatac gccataagaa atggttccaa gctgatttgt 2584141 catttgcggc gtgacttcat actcgtaaac cgtttgatct tctttatcat caccctcatc 2584201 tttaaacccc cttgaaacga tatcatcaag cttctccccg acctgcggct gcttttgaat 2584261 catttgaaga gctttcaata cgtcttggcg gctgatcatg ccgatgagtt tttggtggcc 2584321 gtcagtgacg ggaagcactt cgatcccttc ccataccatc atttgcgcag ctgaagcgac 2584381 agatgttttc ccaataaccg tgacgggatt tttggtcatg actttttcta tagatgcatt 2584441 tcggtcatgg ccagcaatat cttttgatgt cagaatgcca tggattttca tttgatcgtc 2584501 gacaaccggg aagcggccgt gccccgtttc aaaatttttc tcataccatt tttcaagttt 2584561 atccttaggc gaaagatata ccgtgcggtc agcaggtgtt aggatgtcct ccaccaaaac 2584621 aatttctttt ttgatcagct ggtcatatat tgcccggtta atcatcgcgg caactgtaaa 2584681 ggtgtcatag ctcgtggata aaatcggcag ttcaagctca tctgccagct gcacaatgct 2584741 gtcatccgtg ttaaagcccc cggtcaccaa tacggccgcg cccgcttcaa gcgcctgcct 2584801 gtgtgcattg attctgtttc cgacaatcaa aagattcccc gctgcggtgt aacgcatcat 2584861 cgcgtcaagc tccatcgcgc cgatgacgaa tttattcaat gtcttatgga gccctgccct 2584921 gcctccgagc acttgtccgt ctataacatt tacaacctct gcataggtaa gcttttcaat 2584981 gttctctttt ttcttttgtt caattctgat tgtgcccaca cgttcaatcg tgctgacaaa 2585041 ccctttattc tctgcttcct tgatcgctct gtacgcggtt ccttcgctta ctttcatttc 2585101 ctttgcaatt cttcggacag aaattttttc accgacaggc agtgaatcga tatacgttaa 2585161 aatttgttca tgcttcgttg ccaagccttt cacctctaag gacagtcttc ttgtttttat 2585221 tataaggttt caaaggattt atacgcaatg aggctggaaa ataaaaaaga agcccgaccg 2585281 gcttcttaca gcgttgattt cgttccagtc aaacgcaagg accacgtgat tccttttaca 2585341 tcgtaaagcg gaaaaacctt tatttttctt ttaaatggac atcaaccgct gtcttaacaa 2585401 tatttcgatt ccctatttta gataaaacaa ataaaactgc ggatagccat atcgccccta 2585461 tggccgtata gatcaatgga tgaacagctg tgtttgcgat ccattcattt attaatgttc 2585521 tggcatttac cagaataata aatcctccta caagcacacc catcaattgc ggatgaaact 2585581 tctgcaccag ccatgctgcg ataggggcag cgataattcc gccggccatt agtgaaaaca 2585641 cccataacca attgacgtcc tcccatccta atgaaataag aaaaccggcg gttgcagata 2585701 cggcgatggc aaattcactt gtgtctacag tcccgacaac tttcctcggg ctcaagcctt 2585761 tgcgggataa taaaatcgga gtggtcaccg gtccccagcc gcctccgcct gtggcatctg 2585821 caaaaccagc gatcactccc aatgggatgg attgttttcg gtttaacggc acatgcttct 2585881 tctcaagagc cggcttatat tgaaataaaa acctgatcaa tacatatccg cccagaagga 2585941 gcaaaaacaa agaaatatag ggtttcgcca catctccagg taattggctg aggaatgccg 2586001 cgcctaaaaa agcgcctata gagccgggaa tgacaagctg ataaacggtt tgtttgtcaa 2586061 cattgccaaa tttaatatgc gacactcccg atgcggcagt cgttacgact tccgctaaat 2586121 ggacagaagc cgaagccaca gcaggtgtga tgccaaacgc caataacaaa gaagttgagg 2586181 taaccccata agccatacct aacgaaccgt ctattaactg cgacaataaa ccaataaatg 2586241 caaaaacgat taatttcttc atcagaacac cccatctata tcaatcagat atttttgact 2586301 cttcattcga atctaacaat ctcttggcgc tttcatataa aaaataagag gctttgataa 2586361 ttgcagtttc atctattgta aatgcagggt ggtgccaatc atgatcaccg tctgttccaa 2586421 aaaacgcaaa ggatcccgga atatgctcaa gataataagc aaaatcttcc cccgcggttg 2586481 atggggcggg atcaatgact tgaagtttcg ctttatgtgc agcgtctcgc accagccccg 2586541 taattgcctc atcattacaa agcggcggcg gtccggaatg ccacttcaca tttgccttta 2586601 acgagaaagc ggcagaaatc tgctctgtga ctgcaaaaaa acgctgtttc acttgattac 2586661 gaacctctga atcaaatgta cgaacagtgc cctcaatgac cactgtatcc ggaatgacat 2586721 tccaagtgct gccgccgttg attttcccta cggttaaaat cgcgctttgc agcgggttta 2586781 catttctgct tacaatcgtt tgcagggcga caataagctg agaggcgccg ataattggat 2586841 caaaaccatt atgcggcaat gctgcatgag cacctttccc ttctatctct actttaaatc 2586901 ggtcaacagc agccataagc gggcctgttt ttaaccctac agtcccaacc gcgatatccg 2586961 gtttattgtg aaggccaata accgcatcaa tgccatccag ttggccgtcc tctatcactt 2587021 ttgtagcgcc tgcacccgct tcctctgctg gctgaaataa taaacgaatc tttcctttca 2587081 gactgtcttg attttccttc aataaaaagg ccgcaccaag aagcgctgcc gtatgaaaat 2587141 catgaccgca cgcatgcatg atccctttat gtttagacgc ataaggcaat cctgtttttt 2587201 cttcaattgg caaggcgtca atatcagccc tcaaagcaat cgccggacct tctgactccc 2587261 ctgctatgtc tgcgaacaca cccgttttta gagcagtagg gcgaatctgt atcccctttt 2587321 ctttaaggca tttttttata aaagcagttg tttcaaattc ttcttttgac agttcaggat 2587381 attggtgcag gtgccggcga atgccgatga gctgcttttc tagcgttgag agatttacgg 2587441 gattagactc ctctttcaac gtcaggatgt catttcctgt agtctgatat ggataggagc 2587501 cttctatatt tctccaataa tccaaagaca tatgttccgc tcctttccct atcccaatat 2587561 attttcttca gactcttcaa cataagatga aataaatcgg ttcaatttat cagcaagacc 2587621 gcccgcccca aatcttatat acttgctgga aactttcgga ttatcttctt tcaaaaagct 2587681 taaaaaagat aaaatataaa tgcgcctgta agctacttgt gtaattccgt actcaaaaaa 2587741 ccagttatca atgacattgt atacgcctcg gttgacgcca tataggttat tacatttctt 2587801 gtaaaagcag agatccggaa gatttaactc ctgatgggaa agaaggcttt cttttttgtt 2587861 tggtgccata atcccaatca gctcaaagcg ttttgcaacg cacgaaatat cctttttaat 2587921 ttgctttgtt aaagactcca aagaatcaaa ccttctttct tctctaattt taaagagaat 2587981 gctgcattcg attttttctc cataaatgtc tctatgaaag tcaaacaaaa aaatctccaa 2588041 tgtcttttca aggttagagc ccaccgtcgg tttcacaccg atattcataa cccctaaatg 2588101 aaattgatga ttgactgtcg ccagaacccc ataaactcca ttacgcagcc catgtatttt 2588161 tgcatctaca tttgccgtgg ggaatccaag ctttctgcct aattgttttc ctttcacaac 2588221 cgtaccggca atgatcgtca aaaaagtcag cctcctctct cagcttccgc attcgatcag 2588281 acgaaaccta atgatgtgat gaatgtaaaa cggattgatg ctgcggaatg ccaagaccga 2588341 gattttcccg caatgtcccg ccgcgataat cttgacgata aagccctctt tcttgaagaa 2588401 tcggaatcac cttttctaca aaagcatcaa gtgttcccgg tatatccgac ccaacgataa 2588461 acccatccgc cgcctcagcg ttgaaccaag tttcaattaa ggatgcgaca cgctctggtg 2588521 ttccgatgaa tagagtccgt ggaaaagcca tttcctgtgc tacctcccgc aatgtcagat 2588581 ttctggcttt tgcttctctc ttaatccggt ctgttgtgct ttgaaacgca ttctttccca 2588641 catcgccaat atcgggaaat ggctcatcca acgggtaaac actcagatca taatcatcaa 2588701 aaaaacgggc caaataagta acagcatttt caatcggtat caattctgca aattcacgat 2588761 acttcttttc cgcctcttct tccgtatctg ccacaatcgg gctgatccct ggaaaaatcc 2588821 gcacacttga aggatcacgc ccttcatcag cagctcggct tttcacatcc gcataaaacg 2588881 cttttgtctc ttctaatgaa ttggaatggg taaaaatcgc atccgcattt ttagcagcaa 2588941 actgccggcc tgtttctgat gaacccgctt gaaacactac aggctctccc tgcttagagc 2589001 gcccgatatt caagggcccc tctacttgaa aatactttcc tttatgattc aggcgatgaa 2589061 gcttcgcctg atcgaaaaac tgccctgttt tcttattgtg tataaatgcg tcatgctccc 2589121 aggaattcca cagcccgcgc acaacatcca aatgctcttg tgcgatctcg taacgttcag 2589181 tgtgttctgg caaattagac ttactatggt tgcgcgccgc tccttcctgc ggcgaagtaa 2589241 ccagattcca gccggccctg cccccgctga tatggtccag cgacatcaat tgtctggaga 2589301 tagtgaatgg ctcagtaaaa gatgtagaga acgtccctac taaaccaata tttttggtaa 2589361 ccgatgccag cgcagataaa atggtgatcg gttcaaaacg gtttaaaaaa tgaggaatcg 2589421 atttttcaga aataaataag ccgtctgcaa tgaaaataaa actaaacaaa cctttttcag 2589481 ctgtttgcgc ctttttcatg taaaattcaa tattcgtgct ggccgaggga tcaacatcgg 2589541 gatgacgcca gccgtcagtt gttcccccga caccgtgaat catggctcca aactgaataa 2589601 aatctgcacg tgtcatcttt ttgcctcctt tatctgtgca tgattagcaa gtgcaagatc 2589661 aaggtgttca atgccgattt cagttatccc ttgatactga ttgccgcgcc cgatttcgac 2589721 cacaggcaca tggcgcaccc catatttcac ctgtaaaata tcccgaagct tttctttctc 2589781 tgaaacatcg atattttgga acgggaaccc tttttcattc aaataattct tgacttcctc 2589841 acaatacgaa cagccttttt tactccaaac cacaatgttc acaacatcac tcattcttct 2589901 gtccctcctt aacgttttgc agctaaaact gcatcgctca gcagctgata agacagctgt 2589961 ttttctacag catttttgat cggtgtaaaa ataacaaaat cattgatttt gtatgtgcct 2590021 gataaacgtg ttaattcttc tgccacttct tcctttgttc cggcaataat cccggttttt 2590081 tgcacgatga tgtcataggg ctctgtgacg ttttccagat aggcctcagc ctgttcgcgg 2590141 gaaccgacgt tgaccttacg cccgtctttc aaaaccactt ttatcgattc acgcgacaca 2590201 atatgttttt ccgcttcttc ttttgtatgt gccgcaaaaa cagcgggggc aagatgaaat 2590261 tcagcctcag atcctggcgg gagatgcgcg tcaaatgctc ggcgggcttc cttcagcact 2590321 tcctcttcac cgttaataaa gtaagcaaag acaaaagaga ttcccagttt tgcagcagaa 2590381 atggcactct ctgtgcttcc tcccaataga aaaatacccg gcttccgatc aacctgcggc 2590441 ctaggacgca atgcggcata gcggtgggta tcaggaaaat catcccgaac gaaatgagta 2590501 agctcctcca gtttttcatc aaactgacgc accggttttt tatattcggc ctgcagcgcg 2590561 tctgtggaca gctgaaaccc gccgggcgct ttgcccactc caagatctat acggccggga 2590621 gctaacgctg atagaagatg gaattgctcc gctactttat aagagctgta atgctgcagc 2590681 atcactccgc ctgatgctaa acgaattttt cttgtgcttg cagcaagata gcctaaaaga 2590741 acctcgggtg cagaccctgc aatctcatca ttgttgtgat gttcggccac ccaaaatcgg 2590801 tgatatccac attcttcagc catttgtgcc aatttcactg tatgctgtaa tgtatcagct 2590861 gctgtctccc cttcaccaat caagctttgg tctaaaatac ttaagcggat catatcaccg 2590921 gctcctttat gtgttctttt ggttcaaata aatattccgg cgaaacacgg cggagaaact 2590981 gcctcgttct gtcttttttg gtatggcgga agacttcctc cggggttcct tgttcaacaa 2591041 tgactccttc atccataaaa acaacttgat cagagaccct tcttgcaaac tccatttcat 2591101 gtgtaacaac aatcatggtg gctccggttt tcacgatttc cagcattacc tcaagcactt 2591161 caccgaccag ctccgggtca agcgctgccg tcggctcatc gaacagcagc acatcaggat 2591221 gaatggcaag cgcccttgct atccctaccc tctgcttttg tcctcccgat aactgactcg 2591281 gataagcgtt caatttatct tgaagcccga cctttctcag ttcattttcc gctacggcat 2591341 acgcgtcttg ttttctcatt ttccgggcaa tcgtcaagcc ctccatgaca ttttcaatca 2591401 ccgttttgtg agcaaacagg tggtattgct gaaataccat tgccgtctgt tttctgagcc 2591461 agtgaacctc ttttttggac ggaaagcggc aattaatcac tttgtcatgt atagaaatga 2591521 tcccttcgtc tggacgttct aataaattca ggcaccgtaa aaaggtggtt ttccctgatc 2591581 cgctcggccc gataatcgtc acaacttctc ccttgcgtac cgtgagattt atccctttta 2591641 atacatggtg gatgccaaac tgtttatgga tatttttaat ctcaatcata aagtgcctcc 2591701 ttgaaatctg gctgcctttc tctctaatac tccatttgcg gattctagga ttagagtcag 2591761 cacccaatag ataatcgctg ctccgataaa cgcttctaaa aatgcataat tatcagaagc 2591821 aacgatagtc gccgtccctg taatctctgg gacagccact atagccgcga tagaggtggt 2591881 atgcaaaaag ccgataccca aatttgtgaa gtttgggatg gaaaccttca gcgcctgcgg 2591941 caatattaca cgccgaaagg tttggctgta tgtcaagccg attgaataag ccgcttcgac 2592001 ctgtccggta tccatcgcca gaatgcccga ccggatgatt tctgtgagat aagctccggc 2592061 agttaaagac aaggccatga tgacaaacat ggagaccggt atctcattag cggaccagcc 2592121 gagatgaaaa aaactgctga cttgatctgc aacaggcggt atccctaaat aaatcaacat 2592181 aatgtgaaga attgcaggtg tacttcgaaa gaaagacaca taaaaccttg agcaagccac 2592241 caagccctta attctaaaaa ttctaacaat tatatttcca agagccacga gaaatccaaa 2592301 cacaatcggc aaaacagcca tcatcaatgt cagaggaatg gtctttacca tttctttcat 2592361 ggcggaaacg ataaatggaa agtcaaattg caatcttctc ccccctcatc cgaagaaata 2592421 tatcaatgta tgttcatgtc aaaaacagta acaatccttg tttgattctt cttgattcgt 2592481 ttttctgcca ctcgaaagaa ccattcgaat aaaaccgcta cagcataata aacaatcgat 2592541 agcgcaatgt aaacttcaag agaatggttg cttgaggtaa tcagtgtttg gccccttccg 2592601 gacatatcca taacacctat tgaaaaggct agagacgtat cttttaaaga actgatcacc 2592661 atgtttccca tattcggaaa cgcctggaca agtgcctggg gcagaacgat tcgcctgaag 2592721 gcctgactac cgcttaagcc aatactgtac gccgcttccg tttggccttt atctacactg 2592781 cccacccccg ctcgaatgat ttctgcggct gccgctgcat tgcttaacgc gtaggttgcg 2592841 acagcagcat aaaacgggtc catttttgat gtatcaatcc cgataagccc cgtaagcgcc 2592901 gggatcccgt aaaacacgat gaaaagctgc accatgatag gcgttcccct gaaaaacgag 2592961 atatacactt ttgccaattg atttacaatt ggaatattat agatgcgggg cagtgccaga 2593021 aagagtccta atacaaaacc gaaaagcaag gacagtgtta aaatgtataa tgtaaccggt 2593081 aaataagcgg ttaacgtcgg cacaaaatct ccaatcatgt tcatatcaaa cgctttttcc 2593141 atcactgctc cctctctttt tacctaatac tgctctttgg aatagtcgtc accaagccat 2593201 ttcaaactga gccttttcaa cgttccgtca tcaatgattt cctgtaaggc tttatcaata 2593261 tcgtcactta acgtttgttc atttttgtta aacataaaat acactttggc atttgaaagc 2593321 acattaccga cggttttttc tttaatagtg ctcgtcttgt tttgaaagtc tactgcaaaa 2593381 ggcgttgaga tcgttgcgtc cgcacgcccc gatttcagct gattcgcagt ctcatttgcg 2593441 ccttggccct cataggcaat ctcaaacggc cgtccattat cctcattcca ttttttcagt 2593501 acaagcgctc cgttggaggt tgcactcgta atcacccgtt ttccttttaa gtcttcaatt 2593561 ccacggatcg tatcgttatt ttgaagcaca gtaattttta aaggaaaatg gttgtaagca 2593621 accttgttaa acagaaattt tttctcacgc tctttgcttt tctccatttg atgtgccacg 2593681 atatcgactt tatgctgtcc gaggctgaca agcaggttgg aaaattccat cgttttaaat 2593741 gtgaatttat aatgtggcag gcgcttatca agctctttga tcagttcgac atcataaccg 2593801 gttaaatcgc ctttttcatc gataaagcaa atattcggaa attgggttcc agttccgacc 2593861 gtgatcgtct gtaccttctt ttgcccggct cccgtcgttt gactgcctgc accgcaagct 2593921 gacagaactg ttataagcga aaataatatt gccatgaatg ctgttttcgt tttcatctca 2593981 tcgccccatt tatttttcaa aacttgattt tgaataatct gccccgagcc attttcggct 2594041 tagttttttt agcgttccgt ttttctccag ctttttaatc gcttgatccg tgtcatccgc 2594101 caaggtttgg ctgcctttat taaacataaa gtacacctcg gtatctaata acacgtcacc 2594161 gactgtcttt tggcggaagg cgtgcgtttt attctgaaaa tcgacggcaa acggtgtagc 2594221 tatcgttgca tctgcgcgcc cggtttcaat ttgattggcg gtatcattgc ttccctgtcc 2594281 cgcatatttc aaatgaattg ggctgccgtg cgttttgttg tactttgtaa tataatctgc 2594341 cgcatttgac gtggcgccaa ctatgactgt ttttccgtgt aagtctttta atgtatgaat 2594401 cttgtgatta tcctctttca ccgtgatgta catcggcgag tagttatatg ggactttatg 2594461 atacaaaaaa cgcttttctc gttctttatt tttggccata ttgtgcgcaa tcacatcaat 2594521 ttttttattt ccgagactcg tcagcaaatt tgagaaatcc atcgttttaa attcaaatgt 2594581 atattgaggc aactccttat cgatggcttt catcacttca atgtcatacc cggtcaattc 2594641 acctttttca tttaaaaacg caatattcgg aaaatctgtt ccagtgccga ctatgaccgt 2594701 ttgagcctga cgatctgttt tgttatttgt ttgcgaacat cccccgccaa gtaatgcaaa 2594761 cactgacagc agcaaaacca atcctttacg cttattcata ggctgcctca catcatgccc 2594821 agctgggcgc acctaaaagc gttgggttaa atcgttccgg aatcagaacc ttgtgcatca 2594881 tcacacctat gtccccgtct ttttcctgct caaaatacac ttcataccct ctccttctgt 2594941 acatgtcagc aagccaagga tgcttgcgcg ccgatgtgcc gagtgtcagc gcaggagcct 2595001 tcagcatatc tcgaagcact ttttcttcaa catacgtaag cagcttactt ccggcgcctt 2595061 gccctttata ttccggcagt gtcgcaaacc accacacaaa tggatatttt gaaggaggcg 2595121 tctcactctc ccacgggaac ctgattgtaa tcgttgaaat cagcttccca tcccgctcca 2595181 gcacaatcgc tgaatgatgt tcaatatttt ctgataccat ttggatatca gctctcgtgg 2595241 atggccaatc aatatccagc tgccgaatgg gctgaaatgc gctgttaacc agtttcaaca 2595301 gctccgatgc atcttcaaca gttgccagtc gaaaaatatc atcactcatt tttgtcactc 2595361 ctcttcacaa aatatataat tcctatttgt ttactaagct tttattgttt atactataaa 2595421 gcatactctg atctttgact aatcaaaaaa agtaaacctt cacttcagta attttaatga 2595481 tgaaaaacag gagggagcac attggagtta cgctcaatca aaacgtttca tacgattgta 2595541 aaatttggaa gcttctataa agctgcagaa atactcaact actcgcagcc gacgatatcg 2595601 atgcgtatga agcaattgga gcaggattta ggcgtactgc tgtttgaaag aggaaaaagc 2595661 ctgcagttga caaaagcagg gaagcttttt tatgaacgaa caggagatct tttgatgcaa 2595721 tacgaggcgc ttaaacacaa cctctccgac ttaaaggaag aagaggcagg cattatcaac 2595781 ataggggttt cagagccaac cgccagtctg atattccccg agattttaaa ggatttctta 2595841 atggattacc caaagataac ggttaatatc aaggttgatg acgccaatac ctgcagtcaa 2595901 aagctcttag acgggacgat tgattttgca gtctgcggcg agccggagct gattcttgaa 2595961 aattactacc atccattttt ttatgacaca ttaaatgtga ttgtatctga tcaacatccg 2596021 ctcgctgaga agaaggctgt ccatttgtct gatttagcag aagagcgctt catatttacg 2596081 cccgccaatt gccccattcg cttacaaatt gaacagcatt tacatagaga actcgggaat 2596141 cgctacaaaa aaatggagct cacaagcagc atgtcacatg aatattacgt acgtgaaaac 2596201 atcggaattt caatctttac cagcaccgca cattctaaac cgttcaacgg cactaaagtc 2596261 attccaattc tgaacctgga tatcaccccg cccatagggc tgttgacaaa tcaaaaagaa 2596321 gttcattttg accgcgccac gaaggacttg atcgcccgga taaccaaacg ttttcagcag 2596381 cgcagcaaag aattggaagg aacctctgat aagaccatta caggataact gaaaaaataa 2596441 aaaccacctc ctgattcatc aggagatggt ttcacggttt aaagctcgat cgtctcaccg 2596501 accgacatga ctttgccgac tccgcccggc aggctgtcag cgaatgcttc tgggtcttgt 2596561 tcgatgaccg ggaatgtatt gtaatgcacc ggcacgacct gttttgcgcg cagccattca 2596621 gcagcaagct tggcgtcttc aggccccatt gtaaagttat cgccaatcgg aaggaaagca 2596681 aggtcgatat gattcaattc gccaatgagt ttcatatcag agaaaagtgc cgtatcgccc 2596741 gcgtggaaaa tcgttttatc ttctacagtc agcaaaatac cggcaggcat gcctgtgtaa 2596801 gtgatcgttt tgttttcttc atctgtgatg gctgatccat gaaaggcctg tgtgagcttc 2596861 acttttccaa aatcgaactg gcgggagccg ccaatatgca ttggatgaac attcaagcct 2596921 ttccagccta agtacacagc gagctcgttc ggggctataa ccagcgcgtt attttgcttg 2596981 gcgatttgtt cagtatcacc gacatggtca ttgtggccgt gcgttagtaa gatgacatcc 2597041 gcttttacat cctccggctt tatatccgtt aatgaattcc ctgttaaaaa cggatcaaaa 2597101 ataatatgat ggtccttcgt ttccactgtg attacagaat gtccgtgata tgtcactttc 2597161 atttctttca cctcgtcaca tgattttgtt ttttttattt tcccttttta aaaagctgaa 2597221 aaacttatgt tgtttgattc ttgttaatga cattgaggcc tccggtggct tcaatgacag 2597281 tccctgtcac aaggtctgag ttctcctcac acaagaaagc gataatcctg gcaatatcct 2597341 cgcctgtacc ggatcttcct atcggcgttt tttctttgcc gattcgcatt ctggcttcct 2597401 ctatcgatgc ttctttcatg tcgccgacaa tgtctcctgg gcaaaccatg ttggcggtta 2597461 tgccgaattc ggcttcttca atggcaattg tcttcgtcaa agaagccaag cccactttcg 2597521 cagcgccaaa tgccgatcgg tgaagccagc cgggcgcgtg agccgcacct tggaatccgt 2597581 acgtaataat gcgtccaaat tgctgttttc tcataatagg aataaccgct ttgaataaat 2597641 gaaagacggc gcttaaattt ccttccagca tgccatacca ttcatcatca gtataatcgg 2597701 ctaacttttt acgttcaaat atgtatggtc cagcgttgtt aatcaaaaag tcgatccttc 2597761 cgaagcggtt taaggcagcc tctgcaatac gcagcagatc ttcttttttg gtgacatcac 2597821 cttttacaaa ttgcagccgg tcaagacaat cgggacaggc ttccttcagg cggctgactg 2597881 cctcctcatc ctgtctgtaa ttgactgtta ctgaataccc ctttgcaagc aacgtttcag 2597941 tcactttgcg gcctaaaccc ttcgaaccgg cagtaattaa agcatgtcgc acatgaatac 2598001 ctcccaaagc aacgtcgccg ctttcaataa agtgtttctt cttctacttt actataaaag 2598061 gcttgcaata tcacttttta cactttggca tacaaaaaaa gctgcctgta cagacagctt 2598121 attctgcagg agatgaagac tcctgatcag gcatatcgac ataaccgctt tgatatgctt 2598181 ctgaaatgag ccttgttgtc tcctggcttt cttgttcatc ataaatatag cgttccggtt 2598241 cttttttcat cattctgcct cccatcatta tagaggtagg ttggctataa tgacgggatt 2598301 ttatgaagga aattttaaca aactcctgct gccacgcaag ctttcgcttt ttcaagcgcc 2598361 tgttccacct gtttgaatcc ggtgcccccg gcgctcattc ttttttcaac tgcgtagtaa 2598421 gggtctaaca cagtgtaaat atcttcttca aatagtgtgc tcgcctgctg aaactcgcca 2598481 aacggcatat cgcttaaata gatccctctt tcgatgcatg tgtacacaag tttcccgacc 2598541 acttcatgcg cttctctgaa cggcattcct tttttagcta aataatcggc cagttccgtc 2598601 gcgtttgaaa agtcttgttt tgttgcttgc ttcatgacgt ctttgtttac agtcattgtt 2598661 tggatcatgc ctgtgaagat ttgcaggctg ccctccaccg ttttcaccgt gtcaaacatg 2598721 ccctctttgt cttcctgcag atctttgttg taagcgagcg gaagtccttt catgatcgta 2598781 aacagcccca tcatatcgcc gtatacgcgt cctgttttgc cgcggatcag ctccgccata 2598841 tcagggtttt tcttttgcgg catcatgctg cttcctgttg cgtacgtatc gtcaagctcg 2598901 atgaatttaa actcctgcga gcaccataaa atgatttctt cagagaaacg ggataggtgc 2598961 atcatcagca tactgctgtt gcttaaaaac tccaaaatga agtctctgtc gctgacgccg 2599021 tccaagctgt tttcataaat ggcatcaaag ccgagcagtt ccgctgaata atcacggtca 2599081 attgggaagg ttgttcccgc gagcgccccg cagccgagcg gagatttgtt aatccgcttc 2599141 attgaatcct gaaaacgctc cttgtcgcgc tcaagcatcc agaaatacgc aagcagatgg 2599201 tgagcgaatg aaatcggctg ggcgcgctgc aaatgtgtgt agcccggcag aatcgtttca 2599261 acgttcgctt ccgccttttc aatcagcgca ctttggaatg cctcaatcag ctcgatgatg 2599321 tggccgacat gattcttcaa gtataaatgc atgtcagtcg ccacctggtc attccggctt 2599381 ctgccggtat gcagcttgcc gccaagagga ccgatttcgt caatgagcat tttctcaatg 2599441 ttcaaatgaa tatcctcata atcgactgag aattccaatg ctccctcctc tgctttttgc 2599501 aaaagggtat tcaggccctc tcggattttc aactcttctt ctgctgtcag aataccgcat 2599561 tttttcagca tggcagcatg tgcgagagac cctgtaatgt cttcagcaac taaattttgg 2599621 tcaaatgata tggacgcgcc gaactcgtcg acccattttt ccggtgtttt ttgaaatcgg 2599681 cctccccaaa gcttcttcat gctttaatct gctccttctt tttcacgatg ctgttcactt 2599741 ttgtcggaag tccccaaagc tcgataaatc cgattgctgc atggtgatca aatgcatcgt 2599801 cttttgtata tgttgcaagt ttttcatcat atagagagta ttccgattta cgtccttcta 2599861 caattgcatg gcctttaaac agcttcacgc ggacaatgcc tgtgacatgc ttttgcgttt 2599921 cttttaagaa agcgtgcagc gcgtctttta acggtgagaa ccataagccg ttgtaaatga 2599981 tttctgacat tttttgctcg atgatcggtt taaagtgggc tacctctttc accagtgtca 2600041 aatcttctaa ttctttatgc gctttgatca gtgtcatcgc accagggcat tcgtatactt 2600101 cccgggattt aatgccgacg aggcggtttt ccacgtggtc gatacgtccg acaccgtgcg 2600161 cgcccgccat ttcattcagc ttcaagatca gctcagaaag cgagtaggaa acaccgtcaa 2600221 tggagacagg cacgccctgt tcaaatgcaa tttcaatcac ttccggcgtg tccggcgttt 2600281 tttccagcgg agctgttaaa tcgtatgcac cttctggcgg cgccgcccat ggatcttcta 2600341 aaatgccgca ctcattggcg cgtccccaga ggttttggtc gatagaatac gggctgtcaa 2600401 gattgatcgg aatcggaatg ccgcggctag ccgcatattc aatttcttct tcacgtgacc 2600461 actgccattc gcgaaccggc gcgatgactt ctaggtcagg gtttaatgat ttaatggaga 2600521 cttcgaaacg aacctggtca tttcctttcc ctgtgcatcc gtgggcaatc gcctgtgcat 2600581 cttctttttc cgcaatttca accagttttt tcgcgatcag cggtcgagat aatgccgaaa 2600641 caagcgggta ttttccttca tacattgtgt gggcctgcaa agagataagc gcgtaatcct 2600701 gtgcaaattc ttcttttgca tcgatcacgt aggagtttgt cgcgccgact tcaagcgctt 2600761 tctgctgaac aaatgccaaa tctttgccct caccgacatc caggcagcag gcgattacat 2600821 tatatccttg ctcctgaagc cattttattg cgacggaagt atcaagacct cctgagtatg 2600881 ctaatacgac ttttttctgt tctgacatga taaaaatccc ctctcaaccg tgtttctatt 2600941 ttgtataaaa ataaattata tttaataaaa atacattttg tatgtataca ctttaacaag 2601001 tacgtttcgt tttttcaagc cttttataaa aaaaacttca cctaaatttc aggtgaagtt 2601061 tcatagtatt tattcattta cttgtctttt ctgatttctc tgaccacatg cgcaagttcg 2601121 ggaataatca gcttattcat tgccagcttt actgcgccgc ttgagcctgg cgttgagaaa 2601181 acagcggtat gctgaatgac gccggcagtt gctctcgaca tgattgcggc agagccgata 2601241 tcctctgtat aactcagcat cctgaatatt tctccaaagc cgggcagttc tttcgaaaac 2601301 agcggcgtta tggcttcaat tgtgacatcc cgatctgcta tgcctgtccc tccgtttaag 2601361 agtaccgcgt ctgtctgttc atccatgcag cccgcaagca ctgaccgttg caaagcatcc 2601421 ttttcgtctt ttacaatttc atatgcggca atatgatgac cggcttcttc taaaaatgag 2601481 atcatcagct tgccgctttt atcggtttca tctgtcctcg tgtcactgac agtaatcact 2601541 ttgcaccgaa cgatatcggg agcttcttgt ttatgctctt gaacgctcat tggcccacct 2601601 cttttatgtt ttctgtctgt cactatcatg catcaacaaa aaagcacatt caagagaatg 2601661 tgctttcatg cgatttattt tgctaaacga acaacgtcgc gcgcaatcat gacttcttca 2601721 tcagtcggga tgatcatgac ttttactgga gaatgcggat agctgatgaa agcttcctcg 2601781 ccgcgcacgt tattaagcgc agggtcccag tatacgccca tgaattctaa accgcgaaga 2601841 acgcgttctc tgacttccac actgttttca ccgataccgg cagtaaagat gatcgcatct 2601901 acaccgctca ttcttgcagc gtaagaaccg atgtatttgt ggattctgct tgcgaatact 2601961 tcaagagccg tttccgcgcg ctcatttcct tctttcgtag cttcaacgat gtcacgaaga 2602021 tcgcttgaga aaccggaaat gccgagcagt ccgctttttt tgtttaatgt attcagtact 2602081 tcgtcagccg tttggcctgt tttctccatg atgtatggga tcagggcagg gtcgatgttt 2602141 ccagagcgtg tgcccattgc tacaccggca agcggcgtaa agcccatgga tgtgtcaata 2602201 gattttccgc cttcaacagc ggcaatactt gctccgtttc caaggtggca ggaaatcagg 2602261 cgcaagtctt ttaacggacg gccgagaagc tctgccgcac gctcagttac atatttatgt 2602321 gaagtgccgt ggaagccgta tttacggatg ccgaattttt catagtattc atacggcaag 2602381 ctgtaaaggt aagactgctc aggcattgtt tggtggaatg ctgtatcaaa tacagctacc 2602441 gcaggaacat ttggaagcac ttctttgaac gctttaattc caacgatatt tgccggattg 2602501 tgaagcggtg ccaattcaga aatatcttcg atttccttaa tggtttcatc cgttaataaa 2602561 acagaatcgc tgaatttttc tccgccgtga acgacacgat ggccaattcc gtcaatttca 2602621 ttcaagtctt taataatgcc gaattccgtt aacttattca gcagcatttt aacagctacc 2602681 gcatgatctg gaatatcagt tacttctgta tttttttcgc cgttcacaga aattgtgaat 2602741 acgctgtcgg cgataccgat tcgttcaact aaacccttcg ttaaaacggt ttctgaaggc 2602801 atttcgaaaa gctgaaattt caaagacgag cttcctgcgt taattgcaat aattttggac 2602861 atgattgacg ctcctttata ctctgtatca acaacttcgt ttttcgtact tttttcccgg 2602921 tgaatatcaa catcttctcc gaaaaatatc tgacttttcc atttaaacat tgtcatgtcg 2602981 gcttttcaag tcaacttgcg tattgataac gcttacaata agaagtcgtt attttcagac 2603041 acattcacta taggttttgt attgatgaac gcttacaatt tgcggttttt ccctctgtat 2603101 tttgtgtttc aaagctggat tcaattcgtc aagtccggtc ttcaaaagca taaataaaag 2603161 cagcttaggc atcgacctca tacggctgtc taagctgctt ttaaaacact tacttttctt 2603221 ttttaaacca ttcatcaaat tgagccatca tatcaagcat cgccttttga ttggagaaag 2603281 acggaagatt cgcaagcaga atttgccccg gcgctttcgt attctctcct tgtttctgaa 2603341 gcacaaggat gcttttggca tgagcttcgt ctttaaaaat agattttggc agctgcaaca 2603401 gtgcgttgat atgaacctta tctttgaaaa actgtttcag cttgccgctt tgggagctct 2603461 caaacaaatg attcggaatc ataaaaaata agtagccgcc cggtttggta tgcttgacgc 2603521 tctgttcaat aaacagatga tgagcgaagg aatggccttc gtcagctttg agctcaaacg 2603581 cttctgctcc ttcgtcattc ggataatagc cgactggcag atcacaaatg accgtgtcaa 2603641 ctggatcgat aaacaacggc tcaaggctgt cctggtggaa aagctcaagc tcttttttca 2603701 gaaggttcgc ttgggcatag gcgatcttca agagcacatc atcaatttca atgccaaagc 2603761 tgtttgccgt tttttcagac agctggttca gcacggtaaa cagaaggttc ccagttccca 2603821 gggctggatc aagaatggtc agttcctttt tgtccgccat aaatttattc accaaatagc 2603881 tgatgaaaag cccgatcgta tccggcgtca tttgtctgtt tggatgcgag atatctttca 2603941 ttcctttaag gacggcaagc tgaaaagcct tgcgtaccca ctcatgctca tacgtgccga 2604001 attccgcttt ttcaagcaga gcctgaagtt gtttggtttt ctgatcagca ggcagtttca 2604061 gctgatccgt tttttcaaga aaatacattt ctcctgcttc ggccagcgcc tctatatatg 2604121 aaatctgcaa ttcattcttt atcataatcg cggcttcgtt taacagctca tacaccgcac 2604181 ctacatggtc tttttgcata ttgtgttcct ccttgccatg aaaaaagctc cggcggcagc 2604241 ctggagcttt tttccctgct tactttacta atgccttagc agcctcaatt ggcttttcat 2604301 agttcgggtg gtttgttgct tcgcttacat attcagcgta aacgactttt ccgttctcat 2604361 caaggacaaa tacggaacgc gcaagcagac gaagttcttt aatatacaca ccgaacgctt 2604421 cgccaaatga catatctctg tggtcagaca gtgtttccac tttgtcaatt ccgttagcgc 2604481 cgcaccagcg cgcttgcgcg aatggaaggt ctgcactgat tgtgtagacg ttgacatctc 2604541 caagctttgc agcttcttcg ttaaaacggc gtgtttgtgc atcacaaaca cctgtatcaa 2604601 ttgaagggat aacagaaata atcgttacct ttcctttcat gtcagctaac gatttttctt 2604661 caaggctgtt agtcagcact gtgaaatcag gagcttgatc tcctaccttc acttcttgtc 2604721 cgacaagtgt aaccggaccg cctttgaatg taatttcagc cattataatt cctccctttt 2604781 gtatgtatgt ctctatcata gtaaagtttc ctgcaaactg caaagtttat gccaaaaaaa 2604841 agttaactgc ggccagcgca gttaaccttt ttttaataat tcatattgtt catttggttt 2604901 tgattttggc cttggctttg gtttttgtta tttttcttga acatttgctg gatgcgctcg 2604961 agtgtttgag gggctgcgtc taaaattttc tctattaaat gggtattttc atctaaatga 2605021 agcattctga tgcctgtcga tccgacaatt aaaaacgcga tcggcgtaat ggacacaccg 2605081 cccccgcttc cgcctccgaa aggaagtttc tgttctcttg tctcatcgtc ttccgatttc 2605141 ttttcggccg gctttccgcc aaactcgctt ccgcctgcgg cgaatccgaa tccaacttta 2605201 gaaacagtta aaatcacact tccatcaggc gtttccactg gatctccgat gatggtgtta 2605261 acatcaatca tttccttcaa gttttccatt gcggttttca ttaaaccttg gatgggatgg 2605321 tctgccatat acgcttcctc cttaaactga tgaatcattc tttgaagtca ttctagccga 2605381 cggattcttc tttaatacgg atagctcccg tccgtatttg acgaatttga aagctgcaag 2605441 catagcatgt ccaaagcgaa aaaagaatat acactgaaaa tgggtcttgg aaacagggac 2605501 ttgaaacgac gggatcacct catagacagg tttattcaca aagtccaggt ggtcgtagag 2605561 cattgctgcg ataccgccct tcacgcccca tacagcaccg gttaacacac ctgtcactgc 2605621 cgcgtcctga attccgatta ctgtaaccca ttctagtttt gtgatatgta aatgcgcgag 2605681 aaaagacgcg ctgattttcc gcagtctggt gacctgatgc aaaagcattt cgattttatt 2605741 aatgctttgc tgcacatcgt tttgtgtaat ttttttcttt ccgctgcttt ttttcatttt 2605801 ggattcagtt ttttgtttga tatccactgt tccgtcttct ttgttcacct taatcgccgg 2605861 gattgttttt ttgatcctta taaggccaaa cagcgccgta atcttcaagg tcaatttgtc 2605921 attatcatcg gcatgaagat actccagcgc gacatggatt ttcattctga gaagcagtac 2605981 gatccctatg agaataagaa tggctgtcag tacatacacc atattcttca cttcctctag 2606041 gagcattatc gccaattcct aaaaaaataa acccggacgg aagtccgggt tatcggttat 2606101 ttgcggtata atttttcatg caccacggtg gtatccgcga tgtaatcatg aatcccttgt 2606161 tttgtaggtg aaaaggcaac aacgatatat aaaatccaaa tcttatcaat ataccgtcca 2606221 accacttcac gaaaaatcac tgtactccat gtcagcttgc tatcttgctt cacagaaacc 2606281 actttgaggc cgaacaccat tttaccaagc gtctgcctga agtattttgt catgagtgcg 2606341 aaataggcaa gatacacaat aagcgttgtc acactgtagg ccgagaaggt aaacatgccg 2606401 gatgttttcg gcagatccaa tacggtaaag aggggagaaa cgagcaaatg gtttaatccc 2606461 catatcacga gccaatcaag caggaaagcc cagaaacgaa cccaaaagcc agcataggca 2606521 tgtgtcagca gctccgcttc ttgcgggcct ttgatgtcat tgcgctctaa ctcttcatat 2606581 gtcgcgtcca ttattgttcc ctcctacttc gcatagagat acatcattct cggcgaaccg 2606641 gattgcgata gaatttctct catattcaaa aaatcaattt cacttttaaa cattttgttc 2606701 gcgcccatgg aaaacagtga gcctaatccg aagctttcct cataagaaat gacagaggcg 2606761 tttttcaaat ccttgtgatc ctttttcatg gccgtaatgg tatcgtcata aaaaccaagc 2606821 tcatcaacga ggttcagttt tttcgcctgc cgtccgtcat acacgcggcc gtccgcaatt 2606881 ttctttacct ctgctttcgg catgccgcgc ccttttgaaa tgacatcaac aaagccttca 2606941 tacgaattat caaccatcga ttgcatgatg tttttttctt ctttcgtcat ctcacgggaa 2607001 ggagacataa tgtccttatg ggccccgctc ttaatcgttt caaaagaaat gccaagcttg 2607061 tcggcaagct ttgaataatt gacgctttcc ataatgacgc cgagtgaccc ggtcagggtt 2607121 tccggtgtcg caaaaatctt atcagccgct gttgagatgt aatagcctcc tgatgctgcc 2607181 atcgaaccca ttgacacgta aatcggtttt ttcgtttctt tcttgatttc ttccagtttc 2607241 ttatgtattt cagcactttc atacactccg ccacccggag aattcacctt cagaacgata 2607301 cctttgaccg tcttgtcatc ttttgcgcgc tcaaggtttt ttaagaacgt tctgtggtta 2607361 tatccgtctg caccaagcag actgcttgag tccccattat cctgaatggt gccgctgacc 2607421 tctaatacgg caattttact tgagggactg ccgttttcca gcgtcttctc ctgcgattca 2607481 tccgtcagtg atgtgagatc cgtttgagcg cctttgacgc tttcaaagaa actcatagag 2607541 atgctgacga taatagacac gccgaaaatc cccagagcaa tcactaatgc aatccatctt 2607601 tttgcattca ttttttctcc tcctttttcc taaactctct cattatacga ttcaatatga 2607661 aaaatgtttc acttcatgag aaagctccgg cttaacgggc tgccggcaaa cgtggtacac 2607721 ttatggccaa aggtatttta tcacaaatac tggatggcag aaaaacttaa atatgacagc 2607781 aaaggggaaa tgggatatga ccgatcaacg ccgtaatgtt tatttttttc acaaacagga 2607841 tcaggaaacg aacgaacaag cccgctcgtt aacacaatta gcggaagagc atggatttac 2607901 cgttgtgaac cagcactcag acgccaatat tatcgctagc attggcgggg acggcacatt 2607961 tttgcaggca gtcagaaaga cgaattttcg tgacgactgc ttgtacgtcg gcattaccaa 2608021 aaaggggaaa gctcatttat attgcgactt tcatagtgat gagcgagaaa aaatggtcga 2608081 tgcaatgacg tttgaacaaa ttgaagtgag aaaatacccg ctgattgaag tgacagtgga 2608141 tcaagccagt ccttttcact gcttaaacga ggtatccatc cgctcaagca tcatcaaaac 2608201 ctttgtgatg gacgtgctga ttgacgatct gcactttgaa acgtttagag gtgacggaat 2608261 gattatctca acgcctacag ggagcaccgc ctataacaag tctgttgcag gagctgttgt 2608321 tgatccattg cttccatgca tgcaggtatc agagcttgca tcccttaaca ataataccta 2608381 ccggacactc ggctcgccat ttgtcctcag ctctgaccga aagctgaccc ttcgtgtggt 2608441 gcaggacggc aacgaacacc caatcatcgg cttggacaat gaagcactca gcacgagaaa 2608501 tgtgaaaacg atcgaaatca aactgtctaa taagaaaatc aaaacagtca aactaaagga 2608561 caattcattt tgggaaaaag tgaagcgtac ttttttatag aaaataaaag gacaggctgc 2608621 tgcctgtcct tttatgattt ctcatataca atctggccgt taatcacggt ttttttaatc 2608681 tctaaaagat gaagctgtgc ggggtcaatg gcaaacggat caccactgag aactgtaaaa 2608741 tccgcgtcat agccttccgc aatttttccg cgtgacttct ctttataaat gataccggcg 2608801 ctaccttctg tataaagctt tatcgcttca tatacaggta aacattcact ttcattatag 2608861 cttggcccgt tttgctcatg actgcttttc cggaggaccg cggactggat ccctagaagc 2608921 gggtcaacag gctcaatcgg ggcgtctgaa ccgcccgcgc ataaaatgcc tttagatatg 2608981 agggttttcc aggcaaatgc agtcttcatc cggtcttttc cgagacggtc aatgacccac 2609041 ggaaagtcgc ttgcaacgaa gtgcggctga aggtcaagtg cgatcggcat gcgtgctgct 2609101 ctctcgatta attcgttatc aagcacttga gcatgaataa gccgatcatg ccggccgttt 2609161 ttgggcggat gcttttctat tgcgttcagc actttttcaa aagcaagatc gccgattgca 2609221 tgaacagcaa cctccatccc tttttctctc gctttgcgaa tgagccggcc aagggtttcg 2609281 tcatcgtgaa cctgaacacc atttgttgat ggatcatcct gatatggttc tttcaataaa 2609341 gccgttctcc cgccaagcgc cccgtccgca aagattttca tagcaccgaa ctccacatac 2609401 gggccggaca gcttctccag ctgctcccat cgatcgacag cttcatgatg aacgagcaaa 2609461 tggcagcgaa acggatactt tccgccagcg gcagctttct cataagcttt catcggcacc 2609521 gaaacatcac cataatagga caagtcttcc gaatgaccgc ccgtcaggcc ttttgtccag 2609581 caatccttta ttgcagccgt taatgcctca tcaacatagt gctgggagac tggcgggaca 2609641 gccttcagaa tcaaatcctg cgccttatca aacaggagtc cggtcggctc gccatttgca 2609701 tcttttacga tgactccgcc gtcaggatca ggagtatttc ttgaaattcc cgctgcttga 2609761 agagccgcag aattgacagc tattgcatgc cggcatatac gcttgagcaa gacgggcctg 2609821 tcaggaaaca ggcgatcaag atcatgctta gtcaagtagt caggtgtctc aaactgattt 2609881 tcattccagc cttctccaat gagccaatcg tttttaggaa gctgccgctc tctttccttc 2609941 gcagcctgta aaattgaatc tttcgacgtc agtgcggaca gatcgagctg aagctgtttc 2610001 tcaccgtggc cgatcaaatg tagatggctg tcaacaaaac cggggaacat cactgctccg 2610061 ttcaggctga tttcttctgt ttccggcgac ccgtactttt ccttcaaacg ttcatagctg 2610121 ccggtgcctt ttataacacc atcctcaaca taaactgcct cagtccgatc gccttcttcg 2610181 agcatcgtat aaatgaaacc gccgtgccat atcgccttca ttcacgttca ctctctttct 2610241 ttacgccttt ttattggctt tgagctgttc ttcacgtttt cttaattcca ctcgtctgat 2610301 ttttgcagaa gccgttttcg gcaggctttc cacaaattca atttctctag gatatttgta 2610361 tggagcggta atcgtcttca catggttttg cagcattttg acaagctcat cactgcgttt 2610421 ttcatgattt tgcaggacaa catatgcctt tacgatggag cctctgattt catcagggct 2610481 tgcgacaaca gcacattctt ttacttctgg gtgcttaaca agcgcgtctt ccacctcgaa 2610541 aggcccgatc gtatagccgg agctgataat aatatcgtca tttcggcttt caaaccagaa 2610601 gtaaccttcc tcatcttttc ttgctctgtc tcccgttagg aaataatcgc cgcgaatttg 2610661 tgttttcatt ctttccggat ctttaaaata ctctttaaag agcgcaggcg tactgaggtg 2610721 aacagcgata tcgccaacct caccaggttt gcagatttca ccgtcttcat ttatgatctc 2610781 cacctgattt cccggtgtcg gttttcccat gcttcccggt ttaataggcg tatctttcaa 2610841 aacaccaacc aaaagcgtgc tttctgtttg gccatatccg tcccgtacct taatgccaaa 2610901 gtgcttttgg aaaacatcaa tgacttcacg gttgagcggc tcacctgcgg aaacagcgct 2610961 gtgcagggca gaaagatcaa agcgtttcaa gccttcaacc ttcgccatta agcggtattc 2611021 tgtcggagtg cagcagaaaa cattgatttt gtagcgattt aaaagctcta gatatttttc 2611081 tgctttgaat ctgccgtggt acacaaaacc ggttgctccg ctgccaagca ccgctaaaaa 2611141 cggactccat acccactttt gccagccagg ggcagcagtt gcccagacga tatccttttc 2611201 agaaatgtca agccaagcgc cggcagaagt ttttaaatga gcaaatgccc atccatgtgt 2611261 atgtacaaca cctttcggct gacctgttgt cccggatgta taagataaga aagccatatc 2611321 atctcttgtt gtgtcagctg ttttaaattg gcttccgtcc gcttcaattg ataagaggtt 2611381 tttccagccg gcatcatttt caccaataga cagtgtaatc agtttgtcag ccgtactgac 2611441 atcccggaaa gcgccaataa attcggagta gacgatagcg ccttttacct ctgcatgttc 2611501 aatccggtat tcaagatctt tcgcgcgaag catttcggag cacggaatga caaccattcc 2611561 tgatttcagg atagccaaat aaacagcata ggcttcaagc acccgcggaa ccattacaat 2611621 cagcttgtct ccctttttaa atccaagatc agctaaggcc gctccgattt tatttgtttc 2611681 ttccatcagc ttttcatacg accaagattc ttgcttgccc gactcgtcct cccaaagaag 2611741 agcggttttt tgtccagcag cactgaactt ttccatttca ttcactaaat tatattgcac 2611801 aggggcaatt aaatcttcac gttttaacac gaacaactcc tcactttctc cacccattat 2611861 acataaatac aggctctttc cgtaaggata tgcctaaaag caacctctgt aaacatagat 2611921 tttataggcc gctggtcctt ttttatatgt aaaaaatgaa aaagagtggg gataccccca 2611981 ctcctaagcc attatgtgaa attgtaaatt agaattgtcc tccgcccatg ttttgttgag 2612041 caaaagatac aagacgtttt gtgatctctc ctccaacaga accgttagcg cgagaagttg 2612101 tgtctgctcc aaggtttaca ccgaattcag aagcgatttc taatttcatt tggtcgatcg 2612161 cttgagcagc tcctggtact aaaaggttgt tgctgttacc tgagttattg ttagccatgt 2612221 gtctcacctc cttgtgagta tagaatgtgt caaaacacat ggcttcattc agaaaaactt 2612281 tggtaattgt atacaggagc tgaaaattga tttaaaagag ttcagcgaat ttatcgttag 2612341 cttcttgttc gctataaagg gtcattgtct caatgttatc taccgcttct tgaatatacg 2612401 gctcgaaatc aacaaagctt tcaaagtgtt caattttctc ttttttaggg cgtgttttcg 2612461 ggcttggcgg tgtaaagatc gtgcagcagt cttcaaacgg ctgaatactt gtctcatatg 2612521 tgccaatttc ccgtgatttt tcgatgattt ctgttttgtc catggcgatt agcggacgca 2612581 aaatcggtgt tgacgtcacc gcattaattg catacatgct ttcaagcgtt tggctcgcta 2612641 cctgaccgag gctttctccc gtaataatgg caagcccgtt tctcttttct ctgattctgt 2612701 cggctatctg aagcatgagg cggcgggttg ccgtcattgt gtaattttca ggaatttgtt 2612761 tttggatgag ctcttgcgtt tttgtaaatg gaacaatatg aagtgtcatg cttcccccaa 2612821 aacgggacag acatttcgcc agatccatta ccttttgctt tgcgcgctcg cttgtgtatg 2612881 gcgggctgaa gaaatgaaca gcttctaccg acaatccccg tttcatcgca taaaaaccgg 2612941 ccacagggct gtcaaaaccg ccagaaagca tcagcatcgc ttttcctgct gaaccaactg 2613001 gcagcccgcc tgcacctttt tcatcacgaa ttgtcaaaaa tgttgcttct tccctgattt 2613061 cgattctgag cgggatgtct gggttgcgaa catcgaccgt caatccttct gtatttcgca 2613121 aaatatggcc gccgatttca gcgttcatct ggtttgtatc taattcaaat tgcttatacg 2613181 ctctctttgt cgcgacttta aacgtatcac ctggtttata ctgatctttg atagccttta 2613241 gtgcggttgc cttaatatca tcaaggcggc tgtcacactt aattgccagg ctgaagcttt 2613301 gaatcccaaa cacttgcttt aaatgaggaa aaagagcctc aggatcctct ccatttaatg 2613361 taatcgtcat acgatccctg ttggaaaagt attttaaatt cggatagtct ttcaaaacga 2613421 gtctgatgtt ttgttttaag cgctcaataa agctttttct gtttttgcct ttggtcgaaa 2613481 tttccccaaa acgaattaat atatgatcgt aattcatgtt ctacctcatc atttccctta 2613541 attttttgat gccaggacga agcgcgttca taaacggttc tgccacatcg cttgtctggc 2613601 tgtaatttaa actgattctg atgctgcttc cggcaatctg ctctcctttg cccatctcta 2613661 agagaacctt gctgggctta tgttcttttg ccgagcaagc cgatgttgtg gagacgaata 2613721 tatcctgttc ctcaagcatg tgtaaaagca cttccgcttt aatccccggt acagagaaat 2613781 taataatgtg cggcgcgcta ttcatttgag gcgtgttgat aacgacgccc tcaatttcac 2613841 tcagcctatt cataaacaat tcctttacgg cagtcatcgt gtcaagccgt gtgtcaaaat 2613901 cagcagaggc cagattaatg gccttggcaa gcgaaaccgc accagcagta tgttctgttc 2613961 cggcccgtat gcctttttgc tgagagcctc ccgttatgag cggaataagg cgtgttcctt 2614021 cttttacaat aagtgcgcct gtccccttta ggccgtgaaa tttatgcccc gaaattgaac 2614081 atagatcaat gccggccttt tcaattgcca agggcacttt atagatgccc tgcacataat 2614141 cgacgtgaaa caaaatgttc gaatgctctt tcagcacttc tcctgccgct tcaatcggct 2614201 gcacggaacc gacttcattg ttcacatgca tcatgctgac aagcacggta tcgggacgga 2614261 tggctgcttt tagatcttca atagaaacaa atccgtcttc attcacagaa agataagtga 2614321 tatcaaaccc gaacaactct ttcagctgtt ctaacgattc cgtaacggat ggatgttcaa 2614381 tagaagtggc aatgatatgt ttgcctgttt ttatctttga caaagccgct ccttttaaag 2614441 ccgcattatt ggcttctgtg gcgcctgacg taaatacaat atcatatttt tttaggccta 2614501 aggacctttt gatttgattt ttggctgctt gaagcagctg ttccgtttcg gctccatatc 2614561 ggtgcaaaga tgaaggattg ccaaagtatc ggctgctcgt ctgttcatat acgttcaaga 2614621 cttcatcgta aggcttcgtc gttgaactat tatctaaata tatcatcttt tttactcctt 2614681 tatgaaagcg gtacaaggta tgatatttat gttaccataa caaaatttaa tagaaaatta 2614741 cgaaaaacta gtattgactt ctaatttttt taccatataa taagatttgt tcgtttcgtc 2614801 atattatctg acaattaatt gacagaatat tttaacataa ttattaggag gatttttttc 2614861 atgaaacact cactgcctgt caaagatacc attattattg gtttcatgct atttgcgtta 2614921 ttctttggag caggaaatat gatttatccg ccggaacttg gacaagcagc cggacacaac 2614981 gtctggaagg ccatcggcgg atttttactg acaggggtag gcctgccgct tctcggcatt 2615041 atcgccatcg cattaaccgg taaggacgct aaaggccttg ctgacaaagc gcaccctgtt 2615101 ttcggcacaa tctttactgt cgtgctttat ttatcaatcg gaccattatt cgccatcccg 2615161 agaacaggaa ctgtttcata tgaaattggc gctgttccgt ttttgactgg tgtaccagaa 2615221 agactttctt tattaatatt tacacttatc tttttcggcg ttacgtacta tttagcgtta 2615281 aacccatcta aggttgtgga tcgagtcgga aaaattctga ctcccatcaa attcacaatt 2615341 attttaatca ttgttctcaa agccatcttc acgccgatgg gcggattggg cgccgtgaca 2615401 gaagcatata aaggaacacc ggtttttaaa ggatttttag aaggctataa aacaatggac 2615461 gcacttgctt caattgtatt tggcgttgtc gttgtaaatg ctgtaaaaag caaaggcgtt 2615521 acacagtcta aagctcttgc tgcagcctgc attaaagcag gtgtgattgc cgctttaggc 2615581 ctgactttca tttatgtatc ccttgcttat ttaggtgcaa caagcacaaa tgccattggt 2615641 cctgttggtg aaggagctaa aattttatct gcgtcttccc attatttatt cggttcattg 2615701 ggcaacatcg tactcggagc agcgattaca gtcgcatgtt taacaacaag catcggcctt 2615761 gtcacatctt gcggccaata tttttcaaaa cttattccgg cattatcata taaaattgtc 2615821 gttacgattg tcacgttatt cagcttgatc attgcgaatt tcggactcgc gcaaattatc 2615881 gcgttttctg ttcctatttt atcagctatc tatccgcttg ccattgtcat tatcgttctt 2615941 tccttcatcg ataagatctt taaagaaaga cgcgaagtgt acatcgcatg cttgatcggt 2616001 acaggacttt tcagtatttt agacggtatc aaagcagccg gtttttcact tggatcttta 2616061 gatgtgtttc taaatgcgaa tcttcctctt tacagcctcg gcatcggctg ggtgcttcca 2616121 ggaatcgtcg gagcggttat cggctatgtg ctgaccttat tcatcggacc atccaaacag 2616181 cttaatgaaa taagttaatg tcacagaacg cctgcgttat tgcgcaggcg ttttgtaata 2616241 aaaaaagagc ctgctcatta cactgcgggc tctttttcat ggtcgtgatt atctaagcgg 2616301 atatgtcagc tttgattttt tcaactgcac ctggcgcagc cttttctaca gcggcagcgg 2616361 caatttcata agagtcgtca taatcaaaag cataaaaacg tctttccgct tctttcagct 2616421 gttcagataa aatatgattc tggcttctga accggtttcc gaactgaatg attttttcaa 2616481 tgaggatgac ctgctcgaca agttcctctg attcccggct tgccctgttg acgatatctt 2616541 ctgcttgttt caaatgggct ccggcttctt ccatatttaa tggaagttcg tttagttgat 2616601 tgaccgtttc ttgaatatga tgatgcgcgt tctccagcat ctcttgaata tggctcggaa 2616661 tgcctggaat gttgctagtc ttcagcagtc ttgctgtctc agaaattgtt tttttcaaat 2616721 tgctgagcgt ctccctcgcc tgaagctctt cttttctcag cgcttgcaga ttttcacgat 2616781 actcggcatg ctcttttttc acttcttcaa tttgcttctc tattgaagca acttcttcta 2616841 ctaaaagtga gtaggcgaca tgctctgcat caagcttatc tttaacggat gatagcagct 2616901 ttccaatttc atcaaggcgc ttttcaaaag cctgctgttt gccgagctca ccggctgtca 2616961 gcctgtagct ttccttcacc agctcagttt ccgctttcgt atgctctttc tcttctttaa 2617021 gcttgtcgta agcaataatc aattcaggca ttttgcttag tacggattga ccggcttcaa 2617081 cttcgccctc cagctgctga taaacagatt gaatattttc gtcaatgagc tgcaggattg 2617141 cggacgcttc atcaatatcc agttcagtca tcaggacatg ttccgctcgt ttcagctggt 2617201 ttgacagatt ttctaattcc ttatcaagct ggatatgctc aagcttgtac cctttttctt 2617261 tcatttcgcc atagccatcc ttgagctttg caatctgtcc gggcaccgtc tgtttacagt 2617321 cagctaacag cttcggcaca tcatctatgt atgactgaag ccgttcaaga ttgcggtcct 2617381 gctcaagcag tacttttcgt gcagtaatat agtttccgcc ttctgtttct tcttcaaatt 2617441 gtttgatgcc gctccaaatt tcgtccagat ccttttcaag gctgtcataa agctccccgt 2617501 aaaggtggct gtaagccagc aggttttttc gagatttcga atagcgctcc ctcacctgtt 2617561 caatctcttc acggctcttt tcctcacttg tgacaagatc gctgatttcc cgaagaatct 2617621 tttcaatgct tgattcagcc gctgtcagca ggtcgtcgat atgaacgagc acttgattgg 2617681 cctttttaaa ccggtatttg tctgcatttt cctcggcatc ataaaggagc tcttcaactt 2617741 tcggcatgtg ggctgtgaca atctcatccc attcttcacg ccacttctca aagaactctt 2617801 ctgtctgacc cgtcattttt aaatgtttta ttttagacat ttcttccacg atcgaccgat 2617861 tcagaatttc aatcttccac gattccagcc ggtcgatttc ggcgtagatt tttttcctga 2617921 aaaagtagcc tgccgcaaac agcgcaagca gtacaattaa taatccaatg acaaactcca 2617981 taatgagccc ccttgctgtt taccttaatc tgtcagggtg ttttatttat tcagaaagat 2618041 ttcaggatat gtattgagaa aaactgtcgt tttcattgtt attatgatac catgtaacaa 2618101 acattttttg accagaaatc aaaaactttt tgtgcaaaat cggcaggatt tgactatttt 2618161 ttcatggggt gacatcaatg caaaagcgag acggacatat tcacacacca ttttgccctc 2618221 acggctccaa tgacacactc agacaatatg cagaagaagc cttaaaaaaa gggttcgaat 2618281 cgattacttt taccgaacac gccccattgc cgccatcttt taccgatccc acgccgctga 2618341 aagacagcgc gatggcgcaa gcttctttgg aacgctatat tcatgaaatt tccggattaa 2618401 aaaaagaata tcgcggacag cttagcatac ggacagggct tgaagtcgat tatatcgctg 2618461 aatttgaaga cgaaattaca ttattcctag acacatacgg gccatattta gatgacagca 2618521 tcttatccgt tcattttttg cgcacagact cttcctatct atgccttgat tatgacgagc 2618581 ataccttcaa agagctgatt tcagcctgcg gaagcattga agcggtatat gaacaatatt 2618641 accggagtat ctattcttcc attgtagcat ctctcggcgt ttataagcca aaaagagtcg 2618701 gtcacatcac actcgtccaa aaattcatca agctgtttcc atacagcatg tcagagcata 2618761 ttcgcggcct cgtttctctg tgcctgaatg ccattgaaga aaacggaatg gagctcgact 2618821 tcaatacttc cggcttaaga aaaacttacg ctggcggtat ttatatcgag gattggatgc 2618881 tgaatgaagc gaagcaaaag aagatcccgc ttgtgtttgg gtctgatgcc catcaagcgg 2618941 gagatgtcgg atatgcgtat gaggcgtttt tggaacggtg ctagttggtg agcgccacgt 2619001 ctcctgtccg gaagacgctt ctgatccaaa tcttgatttc ttcaaaatac attttataaa 2619061 aatacggctc gtgcggctgc atgtagagta cttctgaaat atattgaggc tggagatagg 2619121 gcatcatcaa gagagatttt aattggagaa taaaatgagg cagcggcagc gttaaatatt 2619181 cacgctgttt ttctccttcc tcaatgatca gctggaagat atacttttcc ttcattagat 2619241 atgtcgacat aatttccctg attaatgtgg agtcaattgt gacttcccgg tagacaaaac 2619301 gagttaattg acgatgatta tgctgatagg ataaaatatc gaaaaccaat tgaagaagct 2619361 gttcctgcgt gctttgagta gagatattgc ttgccgctgt ttcaagcgtt ttgctgtagc 2619421 cttcgtaaaa ctctgaaact aagtgttcca tcaagcctcc tttgccttta aaatagtagg 2619481 agatgtgcgc aacatttaca tcagctgact ttgcgatttc acggacagac gtgccagaaa 2619541 atcctttttg gttaaaaagc atgacagcag attcaataat tttgtctttg gtgcttactt 2619601 tcatacggct cactccttcc tcttgatact attcaagcag aaagccgctg ttcctgtaag 2619661 aacttatcga caaatgccgg cagaaaagcc ggaactttgt tttatattat agaaaaagtg 2619721 agggttttcc atgttccatg tcgaaaaaca atctggagat aaagaaaaag actatcagct 2619781 tctgctaaaa cagctcgaag ccatgaccga agacgaaaca gaccaaatag ctaactatgc 2619841 aaatgcctca gcactgctgt atcattcgct gcctgaagtc aactgggcgg gtttctattt 2619901 tgccaaagaa gaggatggac agcttgtgtt aggtccgttc caaggcctgc cggcatgtgt 2619961 tcggattcct ttcggcagag gggtttgcgg cacagcgtac gcaaacggaa aagtggaacg 2620021 tattgaggat gtaaacgcgt ttccgggaca tatcgcctgc gatgcagcgt ctcaatcaga 2620081 aattgtgctt ccgattcgtg tagacggaaa aattgtcggc gtcttggaca tcgacagccc 2620141 agtgaaaaac cgtttcgacg aaattgatga aaaatactta actcaatttg ccgaaacgct 2620201 agaaaaagcg ttagcgcagt aatataaaag cccaaaactg atatcgtttt gggctttttt 2620261 tattttattg agtcatgaat catcaagcgg tttttcccgc tccgtttcgc gctgtagagc 2620321 gcttcatctg cctcatgcac aagctctttc agcgactttt ttgtttctgt cgtccagcag 2620381 gagataccgc aggaaatggt tacctcgggt ttcgtatttt ttctgaccgc gtaaaccagt 2620441 cgctcggtaa tccgtttccc cactgcaacc ggcacatttg gcaaataaat cgccagctcc 2620501 tctcctcccc agcgggcacc gacatcatgc tttcggatgt tgcttttaat cactgaagcg 2620561 acttgaatta aaatctcgtc cccagtctga tggccgtacg tatcatttac atttttaaaa 2620621 ttatcaatat caacaagaat aaaaacaccc ttttgatgga ttttcatgct gtattgaatt 2620681 ttttcatcta aatacgctcg tgaatacagt tcagtcagct gatctgtttt cacgagatgc 2620741 tcaaggcggt cgcgaagcat tgaattggtt acagccagtg tcgcgtgatg aatcagcgcc 2620801 tgaaacagct tgtacatttc aaatgtaaaa gcgtacagct cctgtttcaa taaaaccgca 2620861 aagcctaaaa gccggtcgtt ttgaatcatc ggagcagcca tcagcgagcc gtaccccgcc 2620921 ttcccaaaaa cagactggcc attcccgatg aaaacccctt tttcaccttc atacagcttt 2620981 tctttcagct cattataaaa atctgacggc ttcgcttctt taaaaaatgc tgtgctgcct 2621041 gggagcaatg ttaggttttc aaaatggtct atatgaaaaa atcccacttc ttctgcctga 2621101 aacgattctg ccattctcac agccagatca ttcattgtat cagtcaatgt cagccgctga 2621161 ttcaggcgtc gtgatgtttc attaatcaat tccaaatttg cgatgcttgc tttggattgt 2621221 tcgtagagct gggcattttc aaacgctttt cccgcggcgt ttgctaacag cgacatttca 2621281 tcaaggcagg catcagtaag aaagctgtca cccgttcctt cagccttcaa caccccgtat 2621341 gtgccctgct gtcctttgat cggaatatag gcgacagatt catttttccg caaaatgtct 2621401 ccggacaaat acactttgag cgcaaaggaa tcggattttt ccccttccat atacagctct 2621461 tttgcaggaa tccctaaaca ttggtcttga tcgtgcgata taaataaaga aaactcaaaa 2621521 agagaaaatg tgcttgtcaa gctttctaaa agctgcttca gcacatctgt ctgatcaagc 2621581 agtgaatgga acagctctgt cattttgtat atcttttttt ggtagatcgt tttgttatag 2621641 agtctttcct gtttcatcga ctggtttaaa aatgaagcaa ccacgtccgg aagcccttca 2621701 ggaatctctt catcctgcct gcacgcaaga tggaaacgcc tgccggagcc gtcctcaatc 2621761 agataacatg aagcgtttat ttttgaagcg gaaaaacgcg cttcaccatc tgccagtttt 2621821 gtcacaaagt ctgatggtga cggtgtaagc gaaacacaaa gggttgaaaa ataggtttga 2621881 atagccgaag tcagccatat gaaagagtcg gtgaatgtga ctttttcaga tttggttaat 2621941 aaaaaatcga gcatatgata atgaaaggcg gataattgat ctttagtttg ttctaccatg 2622001 tttttatcac ctaaaagttt accactaatt tttgtttatt atatcataaa cggtgaagca 2622061 ataatggagg aatggttgac ttcaaaacaa ataaattata taatgacctt tgtgtgaaat 2622121 attgcagcct ttttgttcag cttctatgtt ttcattttgt tccttatcaa taaggtgtat 2622181 cgtgtaactc tctgctgctg gagcgaggat acatgaaaac aaaatgtgca tggtcgaata 2622241 gagcagacgg tttttatttt ccacaaaaat aaaaccaaag gaggagtcac attatggctc 2622301 gctatacagg tccatcttgg aaactgtccc gccgtctagg aatctctctt agcggtacag 2622361 gaaaagaatt agaaaaacgc ccttacgctc caggtccaca cggcccagga caacgtaaaa 2622421 aattatcaga atacggtttg caattgcaag aaaagcaaaa gcttcgtcac atgtacggtg 2622481 taaacgaacg tcaattccgc actttgtttg acaaagctgg caaactagct ggtaaacacg 2622541 gtgaaaactt catgattctt ttagattctc gtcttgataa cgttgtgtac aagctaggtt 2622601 tagcacgtac tcgccgtcaa gctcgccaat tggttaacca cggtcacatt cttgtagacg 2622661 gaagccgcgt tgacatcccg tcttacctag tgaaacctgg tcaaacaatc ggtgttcgcg 2622721 aaaaatcaag aaacctttct atcatcaaag aatctgttga agtgaacaac ttcgttcctg 2622781 aataccttac tttcgacgct gaaaagcttg aaggtacttt cactcgtctt cctgagcgtt 2622841 ctgaacttgc tccggaaatt aacgaagcgc ttatcgttga gttctactct cgttaatcgt 2622901 tttaaaaacc cctgccgcta tgcggtcggg gtttttttat cggctttcgc ctcttgctgg 2622961 ccaacactat cttgcgcctg ctgctcccaa tgatcccgct gcagccgttc ttttgcaatc 2623021 gtacacatga gattcacgct ttagcgctcc tttcatttaa aaggtggtga ttggtcgtgt 2623081 ttgccctatc taatatactc ttttcctttc attcctatgc ggtaaacaaa aagatccttt 2623141 gccttcagtg gcaaaggatc tttttcttat ttatacgtca caaggaagta ttttttcttc 2623201 ccgcggcgca gaacagtaaa ttggttttcg atgcggtctt cacctgatag ggtataattt 2623261 atttccgtct ggcgttcacc gttaatgtaa acagctccgt tttggatgtc ttcacgcgct 2623321 tggcgtttag aaggagataa tttagattgc accaacacat ctacaagtga aagctcttgg 2623381 gtgctgtcaa cttccataga aggaacatct ttaaagccta cttttacgtc ttgagcagaa 2623441 agctctttaa tattgccgct gaacagcgct tgggagatgt tgatggcttg ctccagcgcc 2623501 tcgcgtccgt gaacaagtga tgtcacttct tctgccaggc gtttttgcgc ttcacgtttt 2623561 tctggcgccg tttctgtttt ttcagcgtat gcttcaattt cctcttttga aaggaacgtg 2623621 aagtatttca agtatttgac aacgtcacgg tcgtctgtgt tgatccagaa ttgatagaat 2623681 tcatatggcg atgttttttc tttatcaagc cagatcgcgc cgccttccgt ttttccgaac 2623741 ttcgtgccgt ctgcttttgt gacaagcgga atcgttaggc caaacgcttt tgctccttct 2623801 tcttctgatt ttctgatcag ttcaagaccc gctgtgatgt tgccccactg atcgcttccg 2623861 ccgatttgca gtttacagtt tttgtctctg taaagattta agaaatcata agattgaaga 2623921 atcatgtagc tgaattccgt gtacgagatg ccggattcaa ttcttgagct gaccgtatct 2623981 tttgccagca tgtaattgat gccgaaattt ttaccaacgt cacgaaggaa atcgatcaca 2624041 ttcattttgc cgatccagtc aaagttgttc gcgatgacag ctgggttttc tgctgcttca 2624101 aaatctagaa atctggacag ctggtttttg attttttggg accattcgga tacgatgtca 2624161 gcagtgttta atgtacgctc tgcttttttt ccgcttggat caccgatgag gcccgtcgcg 2624221 ccgcccacaa gcgcaatcgg atgatgccct gcaagctgaa aacggcgaag tgttaaaata 2624281 ggcagcaggt gtccgatatg caagctgtct gctgtagggt caaagcctga gtacaagcgg 2624341 attttttctt cattcagctg tttatttaac ccttcttcat ctgtcatttg ctgaatcaat 2624401 ccgcggaagg ataagtcttc aagtaagtta gtcataagat aaagctcctt ttttaattaa 2624461 aataaaaaac gccccttcgt ttacacgaag ggacgattga ttatcgcggt accaccctac 2624521 taataagaga atgcaaacat tcgtcttatc actttgcctg ataacggatc aggtccgttc 2624581 tttcactact gaaagcctgg ccggctttgt ttgcaaaagc ggttcatgag tgtattcgat 2624641 atatccgtct gtgctgattt tcaccggcca tcagctctct ggaacgtaag gatattctac 2624701 ttgtctcaat ctttaccttt tcatatgaag ctatatcatt tttaacataa ataaaatcct 2624761 gtgtcaacgc cgccttttaa tcctccattg ttgacagatc tccagccggc agattaagct 2624821 cccatgcctt cagcacgcgc ctcatgatct ttccgcttct ggttttcgga agcttatctt 2624881 taaattcgat ctcacgcgga gccgcatggg ctgcaagacc ctgctttaca aataggcgga 2624941 tctcttcttt cagtttatca gacggctcaa atccttccct gagtgcaata aaggctttaa 2625001 tgatttctcc acgcaccggg tcaggctttc cgataacgcc tgcttctgca atagccggat 2625061 gttcgacaag cttgctttcc acttcaaatg ggccgacgcg ctcaccggag gtcatgatga 2625121 cgtcatcaac tctgccttgg aaccaaaagt atccctcttc atccatgtaa gcagaatccc 2625181 cagacacata ccagccgccc ggcatgaaat acgattcata cttttcaggg ttattccaaa 2625241 tggtatgcat catggaaggc cagccctttt tgatggcgag attgcccatt cggtacggcg 2625301 gtagctcgtt gccttgattg tcaacgatcg ctgcctccac tcctggaatc ggcttaccca 2625361 ttgaacccgg tttaatatcc atgcaaggat agttgcagat gagctgactg cccgtttcgg 2625421 tcatccacca ggtatcatgg attcgtttgt taaaaacttt atgtccccat ctgatgactt 2625481 ccggatttag cggctcaccg acactgagca catgccggag tgaagttaga tcatatttcg 2625541 cagccatttc atctcccgct cccatcagca tccgaaaagc tgtcggcgcg ctgtaccaga 2625601 cattgacgcc aagctgttca atcgttccat accagctttc cgggctgaaa cgtccgccga 2625661 cgatgacatt tgtcgctccg ttcagccacg gtgcaaaaat gccgtatacc gtacctgtca 2625721 cccagcctgg atcagccgtg caccaataaa tgtcttcttc ctttaaatca aggacccact 2625781 ttcctgtttg atattgctga atcatcgctt catggacatg caacacgccc tttggcgtac 2625841 cagtggaacc tgatgtatag tgaagcagaa agccgtcttt tttatccatc cattcgatat 2625901 ccaatcttgt gctttcctgt ttcgctgctt catcataatt gatgatattc gtgccgctct 2625961 cagcctctcc cccgactacg aagacatgct gcaagtgagg cagtttgtct accggtattc 2626021 tctccagcag ctcaggcgtt gtgacaacaa cctttgcctc actgttttca agccggtctt 2626081 tcaccgctcc ctccataaat gcttcgaaca gcggcccggc gatggcgcca attttgattg 2626141 cgccaagcat aataaaataa agctcgggtg atctcggcat aaaaataaaa acgcggtccc 2626201 ctttttccac atttccatac cgtctcagca cattcccggc tctgtttgat tcttccttca 2626261 tttctttaaa tgtgtatttt tcatcccttt ttgcgtcttt ataataaagc gctactttgt 2626321 tttttcgaaa cgattcggca tggcggtcaa tcgcttcata cgccgcattc agtttccctg 2626381 tctcatgcca agagaaatgt ttctctgcct cggcccaatc aaaatgccgg tacgtttctt 2626441 catagttttt taagttatga tccccctcta ttgctggtaa cgctttcaag ttcatgccca 2626501 aacatccccc tttgctgaag ttgtcacaat tattatagta tatattcata ttcttctcaa 2626561 tttttaaaat ataaaccatg ttgaaaacgc tttataattt ggtattctta aagaaggcat 2626621 gtatttttga taagaattga tgggacggtg aattagtgga acatcataaa acataccatt 2626681 cagcaaacat caaaacagca accggctctt tactgataga agggcctgtc tctccagagg 2626741 atttggcagg ttatgagttt cataaagatt taaccgcatt tcgcccgcct cgcgagcagc 2626801 atgaagcgct agtcgacatt gcaggccttc ccgaagggcg cattattatt gccagagacg 2626861 gccgaaccat tgtcggctat gtcacgtatt tatatcctga cccgctcgaa agatggtctg 2626921 aaggaaatat ggaggatttg attgagctcg gagccatcga agtagcgccg gactatcggg 2626981 gatgcgctgt cggaaagacg ctcctgaccg tcagcatgat ggatgaacaa atggaaaact 2627041 acattgtgat gacgacagaa tattactggc attgggattt aaaagggatg aaaaaagatg 2627101 tgtgggaata cagaaagatc atggaaaaga tgatgaatgc aggcggattg gtctggtttg 2627161 caacggatga gccggagatc agctcccacc ctgcaaactg tctgatggcc cgcattggaa 2627221 aaaacgtcag ccaagaatca attgagcaat ttgacaggct ccgtttttat catcgttata 2627281 tgtattaact gacactgaca aaggggaaaa aataatgatt gttgagcaaa tcatgaaaag 2627341 agatgtcatt acattaacga agacggatac gcttgaaaca gcaatatgca aactgaagga 2627401 attccatatc aggcatctgc ctgttgtaga tgaagaacga cacgtgatcg gcatgattac 2627461 agacagggac atgaaacagg ccagcccgag tatttttgaa gaaaacaaac gaagcctatt 2627521 tctcacacga agcgtagatt caattatgaa aaaggatgtt gtctgcgccc acccgttaga 2627581 ttttgtcgaa gaaatatcag ccgtgttcta cgagcatggc atcggctgcc taccagtggt 2627641 acaccatcaa aaattaatag gcattttaac aaaaaccgat ttgctgcgga cgtttgtcaa 2627701 attgacaggc gctgaccagc cgggctcgca aattgagata aaagtaaacg acatcaccaa 2627761 aagcctcgct gagatcagca gtctttgcca agaccttcaa gtgaaaatat taagcgtgct 2627821 tgtttatccg catgacgatc ccggtgtaaa agtgcttgtc ttccgtgtaa aaacgatgaa 2627881 tccgctgccg tttttgcagg cattacaaag aaatggacac cacgtcgtat ggccgtcaga 2627941 gcaaagggat ctgctatgag agacagtgta tttatctatt ctccatccta ccaaacctat 2628001 atgtttcatc aggagcatcc ctttaatcag cagcgggttc tgttaacata tgatttgctt 2628061 aagacgatca atgcctttga tgatggagac attgtcaccc ccagactcgc ttcagaagag 2628121 gagctttccc ttgtccacac ggacgattac attcaggccg taaagcttgc gggcgccgga 2628181 aagctccccg ctgaagaagg agaaagctac gggctcggca ctgaagacac acccgtcttt 2628241 gccggcatgc acgaagcggc atcactcttg gtcggcggca ctttaacggc cgcagactgg 2628301 gtcatgtcag gacaagccct gcatgcggca aaccttggcg gagggcttca tcacggcttt 2628361 cgcgggagag catcaggatt ctgcatatac aacgacagcg ctgtggctat tcaatatatc 2628421 cagaaaaaat atagcgccag agtgctttat attgatacgg acgcccacca cggggacggt 2628481 gtgcaattta cattttacga taatcctgac gtatgcacgc tgtccattca tgaaacagga 2628541 aggtatttat tccctggaac cggtcagatc caagaaaaag gaagcggaaa aggatatggc 2628601 tattccttta atattccgct tgacgctttt acagaggatg attcttttct tgaggcttac 2628661 cggacagcag cttcagaagt cgccgcgtat ttcgagcccg atgtcattat cagccaaaac 2628721 ggcgccgatg cccattacta cgacccgctg acgcatttat cagcaacaat caatatatac 2628781 gaagaaatcc cccgtcttgc acacactttg gctcatcaat attgcggagg gaaatggatt 2628841 gcagtcggag gcggcggata tgatatttgg cgtgtcgtgc cccgcgcctg ggccagaata 2628901 tggcttgaaa tgaagggaat tgacccgggt cacgagatcc cgccggaatg gattgttaaa 2628961 tggcaaaaac aatgccccgt ggcccttccg tcgagctgga gcgatccggc tgatttatat 2629021 cctccgattc cccgcaagcc tgaaattaca gaaaaaaatg cccaaactgt cagcaaagca 2629081 ttatatgcga tacgttctga acagcaaaga acaaagtaaa aaacgacctt tacgaagagg 2629141 tcgtttttga ttttttaatc actatttcca cacgccgatt ttccttcatg tgttcatttg 2629201 tcttgttatc ctttactggc tttgtatccg cataaccgac agcaataaag cgcttggagg 2629261 gaagcttctc tttagacgtg aagtattgaa tcactccact tgcccgtgct gctgatagct 2629321 cccagttcga cgggtatcgg tatgtcgaaa tgtttcggct gtctgtatgt ccctcaacct 2629381 gaatgtcatt tggaattgtt tgaagaagaa cggcaatttg gtgaagaagt gtttcggcat 2629441 ttttcagcac ctttgcctca cctgtatcaa acagcacagc ctcctgaaga acgagcacga 2629501 caccgcgttc atcccgtttg gctgtcattt gggccttcaa atgattgtct tttatatatg 2629561 tatttacttt cttgagaagc tgatcctgct gatcctcttg cttcttcgta tcagatgggg 2629621 atgtattctt tttttctatg gatgtttggt ccggctgaag cccgttgcct tccttctgga 2629681 tcgagtccac tgccgctttg aatttttgca gatcgatttg ggacatcgaa aagagtaaaa 2629741 taaagaacac aaggatcaag gtgatcagat ctgtaaaggt taccatccag ctggatgaag 2629801 attgactgtt ttttccgctt ccattccttc tttcaaaacg ttctcttcta agcttcatgt 2629861 acagatccct tttttgtttt tacttgtttt ggctgcttct gccattcttc ccgtgagctg 2629921 aaaacgacca gctggctttc aaggttgcgc gggttttttc cggattgaac accgataatc 2629981 ccttccacca ttacctgctt gatgaaaatt tcactttctg ttttctcttc aagcttagcc 2630041 gcgatcgggt tgaagaccat atttgccagt aatgaaccat ataaagtcgt cagaagcgca 2630101 atggccatgt ttggtccgag catatgcggg tcgtttaagt ttttgagcat cagcacaagc 2630161 ccgacgagtg ttccgatcat tccccatgcc ggagcgaatt ctcccgcttt ttcaaaaact 2630221 cgccgccctt ttcggtgccg ttcctccatt gctgcgattt ctgaatccat gacgagccga 2630281 atcgtttctt catcccagcc gtcaatcgct aaaagcagcc cttttttcaa gaatggatct 2630341 ttgatttccc gagcctgatc atccaatgat aaaagcccgt gttttcgcgc gtgatcggaa 2630401 agggaaacaa aggttttcac aagatctttc acattgtctt cctggcggat gaatgcctgc 2630461 tttaacacag agggcgcttt tttcagctca cttggcggaa aactgataaa aacagcggcg 2630521 caaagtcccc ctgttacgat gaagaaagag gtcagatcaa gaaaagagcg gaaaccgctt 2630581 actcccgatc ctgaaataat cccgataaca ataataatcg ttcctaacac aaatccaaca 2630641 ggtgtaagat aatcaaaacg tttcatcatt tctccccatg aaaaaagcaa gaattcacca 2630701 taaaggtgaa gcttgctctt tgtttttctt atgacttggt tgactttcta agctctatac 2630761 ggtgcggcag ttcgacgata tgctcttcaa ccggctcttt attcatgagc ttcgtcagca 2630821 gtctcatcgc aacggcgccg atatcatatg tcggctgaac aactgttgaa agctgaggac 2630881 gaaccatgag gcttaatctt gtattatcaa aaccgataat gtcgagatcc tccggaatgg 2630941 ataagccctg atcctgagcg gcatggataa tgccgagtgc catttcatca gttgcagaaa 2631001 gaatggctgt cggtttttta tccaggctca tcagatgctg cagtgcttcg agtccggaat 2631061 catatgtgta atccccttca gctacaaatt gttcattaaa cggaaggttc gcttcttcaa 2631121 gcgcacgttt gtagccttgg agttttttcg aacggttgat cggttctgcc attggtccgg 2631181 aaacgaacgc gatgtctgta tgtcctttat caaccaaaag cttcacggca tcataaatcg 2631241 cctgttcgta atcgatagcg actgacggtg tttcctcctg ctcttctaca gaagcggcaa 2631301 gtacaatcgg cactggagaa cgcttaaatt ccgccacatg ctcgtccgta atgtttccgc 2631361 ccataaacac gatgccgtcc acttgtttgc cgagcattgt gtttaacaag tgcagctctt 2631421 tctccatgtt ttggtcagag ttgctcaaaa taatattgta tttatacatt gtcgcgatat 2631481 cttcaattcc gcgcgcaagc tctgaataga aaatgcttga gatatcggga atgatgacac 2631541 ctacagttgt tgttttttta cttgccagcc ctcttgccac cgcgtttgga cggtaaccga 2631601 gacgttcaat ggcttccaag acttttttcc tcgttgtcgg ttttacattc gggttgccgt 2631661 tcacgacacg ggaaacggtt gccatgctta cattagcttc tctcgctaca tcgtagatcg 2631721 taatattgct catcctaaaa ccactccttt tactggatac acttatcctt atctatagca 2631781 taaacacttt atgtagagaa atgtcataat gtccgaattt atgtcgttta tgatttgtaa 2631841 gcgtaagtca gtagtgtaca ttatttttca ttattcatca aatttaatta cttctcatga 2631901 aattatacac gtttttatag atgatgaaaa cgtatacttg gtttttataa ctaaataaac 2631961 gagaaagcat aaaaaaaggc cgcaggcgcg gccttttgga ttgttcaatt aagcgttgac 2632021 tttcaccatt ggcttcagtt cattcagcca tttttcgaat tcaggaatcg ccatttgctg 2632081 agcagagtca gaaagtgcga ctgacggatc agggtgaacc tcagccatta cgccatcagc 2632141 accgatcgct aaagcggctt tagctgtcgg aagcaagagg tcacggcggc ctgttgaatg 2632201 cgtaacatca acaaagactg gcaaatgcgt ttcttgtttc aaaatcggca cagctgaaat 2632261 atccagcgtg tttctcgttg ctgtttcata tgttctgatt ccgcgctcac aaaggataat 2632321 ttggtcattt ccttgtgaca tgatgtattc agcagcattg atgaattcag agatcgttgc 2632381 agcaagaccg cgcttcagaa gcactggctt tttcacggcg ccggccgctt tcagcaattc 2632441 gaagttttgc atgttgcgcg ctccgatttg aatgacatca atgtagtcca gcgcttcttc 2632501 gatatgagcc ggagttacga tttcactgat aaccgccaga tcaaattcat ccgctacacg 2632561 ttttaaaatt tgaaggcctt caacaccaag cccttggaaa tcgtatgggc tcgtacgagg 2632621 cttaaaggct ccaccgcgca aaattttaat cccttgtttt ttcgcagctg cagcgacttc 2632681 agctacctgc tcatagctct ctaccgcaca tgggccgaca atgaatcttt gctggccgtc 2632741 tccgattttt tcgcctttga tatcaacaat tgtatcttca ggttttttct tgcgggagac 2632801 aagcagcgct ttgctgtgat cttcttcctg aagctctaaa ccggctttga atatctcttt 2632861 aaaaatgtgc tggatggttg aattttcgaa cggcccgtca ttgttttcaa tgatattgtt 2632921 taacattgtg cgttctctga cagggtcaaa tcggttgaca ccctgtgctt ccttcgcttt 2632981 accgatctct tttacaacat tgccgcgttc gttgattaat tttaaaattt gtaggtttaa 2633041 ttcgtctgct ttctgcctta aaagctctaa ctctgtgttg ctcatttttt tcatcctttc 2633101 cctgcacatt cattttttat tttgtagtta tcatgcatct tactataagt aattccaaat 2633161 ggaaatactg aaatacaaaa aattttataa aaactctact ttattaccca aacgctttta 2633221 agtgataaag taatctatga agctatccta catgatgtga gggcaatgtt caagggtttt 2633281 ttacaaaaaa aagcgccaga tgatatctgg acgctttttt ctatgacaaa tgctgctcaa 2633341 tagcggcttc tgtaatttgt gaatgtgagg tatgccattt cacttcaccg ttctggatga 2633401 tgaatatctg agggctttca tgcttgaccc catatgtttc tgcaatgaaa ttggacagcg 2633461 gccgggcttc ttgtacttga agatagtaag ccggcacatc ctcatgctga tttgcaaagg 2633521 catcaaactc atgaaatgct gcctggctga tcgggcatgt ggtgctgtgt ttcaagaaga 2633581 cgaaaacgcc ttcctgttct gcaatccgtt taaattcttc ctcagattga ataagctgtt 2633641 tagccatgac tcaagctctt ccttccctgc tcagcgattc aactgctcag cctgtttttg 2633701 tgcatctttc agttcgtctt ttacatcttc tttcgtctgg aggacttgat cttttgtttc 2633761 atcagctgcc tgcatcgctt cttccctcat atcttgcatt gcagtcgatg aatccgtttt 2633821 gtcagatttg gaacggtctc tcaaatcctt taccttgttc atgatctgtc cagactgatc 2633881 cgctacaagc tgtgtgatgt tggaagtttt gtcttttgcg atgctgacat attgcgtgcc 2633941 tttttccttc gcatctgccg tcattttatc agttttgtcc cgtaaggcaa cagcctggct 2634001 gccgagatcg tcgcgaagtt ctttgcctga tttaggcgct agaaaaagag ctgtagtggc 2634061 accgatgatt cccccgatta aagttccgat taaaaaatct ttactattaa ttccatcttt 2634121 gctcatcatt attcctcctc ttagtatttt tttctcttac agggctgatt ttttcttttg 2634181 cttccatttc tcccaaattt ccattgctgc ttgactccaa gtgacaactt gattgatctt 2634241 atcttgattc tctctaactg atgccgatac agaccctgcc gcttgtttca tggatgtatt 2634301 gaactgctgt acagaagctc ccactccttg aacagcatga acgaccgtgt tcagcttttc 2634361 tgatttttcc tgaatatctt cagccaggcg gttggtctta tgtaaaagct cggctgtttc 2634421 agttgtgatg cccttcattt gtccctccag cccttcaaga gtggatgcga cgttttttag 2634481 tgtcagctgc agtgacttca atgttttaga caagtagatc actaatacga gaaatgcaac 2634541 tgcgatgagt gcaacgctca aataaagaat aataatcatc tcaaacctcc ttgctgcagg 2634601 atatactgct gtttacccgt tttcttcaat cataaacatg tgtactgggc tgtatacata 2634661 ctattctccg ttatgtaaga aaatccttta ataagctttc ccatcagata aataaaaagc 2634721 agtgagatca ctgcttttta ttatgccatg acgttttcgt aggctctcat atatttttgg 2634781 atatctcctg ctcccatgaa gatgagaacg gctttatcat gagcttttaa aacagatgtg 2634841 tcatcttctt caatcagctt ggcattatga atttttccct ggagatcacc gatcgtcagc 2634901 tttccggcat tctcacgggc tgagccgaaa atatcgcata aatacacaca gtcggcgccg 2634961 ctcaggcttt ctgcaaattc gtcaaggaac tgctgcgtcc gggtaaatgt atgaggctgg 2635021 aataccgcga caatttcccg atcaggatac ttctgtcttg ccgcctcgat tgtcactttt 2635081 atttctgtcg gatgatgggc atagtcatca atcagcactt gatccccaag ctgcttctca 2635141 ttgaatctgc gtttgacgcc cccaaaggat ttgagagcat gcttaatgat gctggaatca 2635201 atttcttcat aatggcataa cgcaatgacc gccaatgagt ttaatacatt gtggtggccg 2635261 tacgcaggaa tataaaacgt atcatagaac gtattgcgga caaagacatc aaaagttgtc 2635321 ccttccgtgc tttttacgat gtttctggct tgaaaatcat tttcttcccc cgtgccataa 2635381 tacacaaccg ggacgttcgc atggattttc ggcagatgct catcgtctcc gcaggcaata 2635441 atgcctttgt tgacttgaag agccatctct tggaaagcgt caaatacatc gtcaatgctt 2635501 gagaagtaat cagggtgatc aaaatcaata ttcgtcataa tcgcataatc tggctgatag 2635561 cttaagaaat ggcggcggta ttcgcacgct tcaaacacaa agtattcgct gttttcattt 2635621 ccctggcctg ttccgtctcc gattaagaaa gacgtcggtt ttgcgttttg gatcacgtga 2635681 gccagcagac ccgtagtcga cgttttgccg tgtgcgcccg taacggcaac actcgtgaat 2635741 tttttcatgt agtcgcctaa aaacttatga taacgtatca ccggaattcc ctcagacatc 2635801 gctttttcta tttcaggatg cgtgtctggg aatgcgtttc cggcgatgac tgtcatgccg 2635861 ggtttaatat tttccgcgct aaaaggaaga atcgtaatat ttcttttttc aagcgctgtt 2635921 tgcgtaaaaa taaatttttc gatatccgat ccttggacag tatatccatt atcatgaagt 2635981 atttgggcaa gcggactcat accggtccct tttattccaa caaaatgata aacagtcata 2636041 attgtacctc caacaaacgt ctatctgttc cccagtatat gacgctcatt tcaatttgcg 2636101 accgcggcgg ctgaaaagcc tcccttagcg gcgtatttta tatgttttgt tatgtttagt 2636161 atcaggttat ttctttccga ttaaacccag atatcaagat ttgtctatgc acagctgctg 2636221 taaagcggca tagctgttaa atgctctaaa cactatcata ccatgtttgg tgtgaaaatg 2636281 aacccatatt attcgtttat taaatcactt gctgtgatca gcacctctcg aggcttgctt 2636341 ccttttgcct cagagatcat gccttccgct tccatcatgt cgatcagcct tgccgcacga 2636401 ttgtaaccga ttctgaatct tctttgcagg cttgaagtgc tcgcactgtt ttgctctaca 2636461 acaaactcac acgcttcgta aaacagttcg tcctcttctt tcagggcaga tccttgtctt 2636521 acgagctctt cttgttcaaa taaataggtc ggcggcattt ggcttctgac gtgggaaacg 2636581 acgcggtcga tttcccggtc tgacacaaag ttaccttgca gacgaaccgg ttttcccgag 2636641 ccgttttcca aaaagagcat atcccctttt ccgagaagct tttctgcacc ggctatatca 2636701 ataattgttc gggaatcaac ctggcttgag acagaaaagg cgattctcgt tgggatattc 2636761 gccttaatca gacctgtaat gacatcgact gacggacgct gagttgcgac gagaagatgg 2636821 ataccgcacg ctctggcttt ttgggcgatc cgcgcaatgc tttcttccac atcgtttgga 2636881 gccaccatca tcaaatctgc aagctcatca ataatgacaa ctaaatacgg cagcttttca 2636941 cccatttggt gttcagcggt taattgatta aagcggtcaa tgtcgcggac acctgaatgg 2637001 gcaaaaagct catagcggcg ctccatttcc tcaacgaccc atttcaaagc agccgtagcc 2637061 gctttagcat cagtaatgac cgggctgacg aggtgaggaa ttttattgta aggggccagc 2637121 tctaccattt tcggatcaat cagcagcacc tttacctcac tcgggtcagc tttataaagc 2637181 aggcttacta atattgtatt gatgcatacg ctttttccgg agcctgtagc gccggcaatc 2637241 aagccatgcg gcattttctt caagtcgata acaacaggat ttcccgaaat atctaatccc 2637301 agcgcagctg tgagcggtga cttgcttgtc ctgaaagctg agctgcgaat catttggcgc 2637361 aaatcaacca ccttgctcgt gcggttcggc acttcaattc cgatcgtgtt tttccccgga 2637421 atcggcgctt caatccgaat atctttagct gagagactga gtttaatatc atcggacaag 2637481 ttggtgattt tattcacctt tacacccggt tcaggatgca cttcaaatct cgtgacagac 2637541 ggaccctggg ttacatggac cacattggcg cggacattga aatttttcaa ggtcaaatca 2637601 agaagctgac gctgttcttc gatccacgca gtatcatctt gaacctgcgc tggcgggaca 2637661 tcaagcagtg caacattcgg aaatacatag ctgccgcggc gctcctctgc tttttgctgt 2637721 ttatgcgtat ctcttttcag catcatcaca ttaaaaggaa cggatggccc tttttgagaa 2637781 gatgcgcttt gttcagtcct tttctcctgt acaccaggcc tttttttcgg ctcttctgaa 2637841 gcttcgcgag gtttgtctgc gcgaatttcc tgccggtttt caagagttgc agtagacgat 2637901 ttggaaccct gctccatgtg ttcagttttc tcaagctctg tatggctgtc tggctgaaca 2637961 tctatcttcg tttcctgagc ctctcccagg gtgtcataat gattatttat tatgctttct 2638021 gatggctctt ctgattcttt tgccacagtt tctgcttgag ccagagcctc tgatgaatac 2638081 tcatgatcag taaataaagg ctcttcctga cgaatgtcca tttgttcttc ttgaacgaac 2638141 ggggactcag caccttctgc cgcgttttca tgatgattgt atactgggct gtctgacggc 2638201 tcttttgctt tttcatcctc agatactgcc tctgtctgag attcaggagc tgtttgctct 2638261 tcatcaagtt cagcggagaa aacaggctct tcaaatttct ctggctgctg ctccctttgt 2638321 tcttcctcag ccgttgcagg ctcttcgcgg cctacttcac tgtctgaaag cccttcagcc 2638381 gccgtatctg tgagcatctc aggcggtgtt tgctcttcgg cttgttcagc tgggaagaaa 2638441 ggctcctctt tttccggctg ttgaacgcct gactcaaatg gcactttgtt acctgacggc 2638501 tcggctggcc gtttcgccag cgcctcatca tgctccgtat cctttctgtt taaaacgcca 2638561 gaaggctgtt tttcaaattg ggtatccggg aagaaaggac tttctatttt ggaatgcgcc 2638621 tgtgtgtctg aagcaggata gccgcgttca cgttcgatct cttctgacag cagtgttacc 2638681 ttctctttta ccgatttatc cggttcgttc aatgtttcag aaggcttttt cggcacatcc 2638741 tttttaacag atggtttttg attgaatcca tagacaggcg aagggatatt tgtcggttta 2638801 aacggtttct tcgccggctc tgctgcttga tatgtatgct gctcttcttc atttctggga 2638861 cgctctctgt aaggtgcagc acttggacga ggcgcggatt tcggttcgtc cgatggtgtg 2638921 cggcgccttc tcaggtcatg atttttgtat ccgtcaggca cgactggaaa acggaatttg 2638981 ccttttggat attcataata tattttagga tcttccaatc tttttaattg tccttcagga 2639041 tgatgtactt cttgttgctg cggaatttga gcgggttttg tctcccgttc agcatcctct 2639101 tcgctttcgc ctaaaaacaa atcaaaaaat ttatgaagcc aactcataat ttatctctaa 2639161 ctcccttata gttttctggg acggttttta gtataccact gctggtcggc ccagaaaaga 2639221 ttaagctatc agcagaaaca aagccgctaa acaagggctt agcggctttt cacatgattc 2639281 gttttttttg gcggatttat gggagtctaa aactgaaatg cgtctcccgc ctcatagtct 2639341 ccttctaaca caaggattcc tttttcagca ggggcatccg gcaaatcaag ctctttcgct 2639401 gagcagatca tcccgcttga cggaacgcca cgaagctctg catccttaat gacaagtccg 2639461 ctaggcatca cagcaccgac tttggcaacg acaacttttt ggccttggtc aacgttaggc 2639521 gcgccgcaga cgatctgaag cgtttcttct cctacgttga ctttacatac gcttaattta 2639581 tccgcattcg gatgtttttc ttttgattct acataaccca caacaaactt cggagataaa 2639641 tcaacgacta atgtttcttc aacgccgttt ctgtttaaaa tctcattcac atcttgcacg 2639701 aatgtttctg agagcgcaac agggccgttt tcatcaatgg tcaagtaaga agacgcattg 2639761 aaaatgttga agcccgttgt ttcttttgtt tcgttattga aaattttgac gacgtcgccg 2639821 tgtttttcat agcctaattg ttcgcgtgtc acatcttgaa gagagatcag gagcgtgtct 2639881 cccacacctt ctttattata aaaagcgttc ataagtaaaa atcctttcta atcctttttc 2639941 ggacggcttt tcgccaggat aaacaccggt tccagctttc cttcattgta caaaaatgat 2640001 agggcggtaa tcgggacggt gccgcctgca aagaagctca tcgacatttg tcctagaata 2640061 tcataccccg attcattccg gatgtcagca agaatcaaaa cgtcctgatg aggaacagag 2640121 atcgccagct caccttctgc atgctgctta tactcattta agatcgcttc gttcaaaatc 2640181 cggcttgcgt cgtatccgtc gtttgccctg aagaaataaa agtaattgcc ggcaaccgta 2640241 tcctctttga caaccgtcgg cagggaacgg agattaaatg cggccgtctc tctgatccgc 2640301 tcttttgtcc agttttcttt ctcaagcatg cgctggtcaa ttaaacggta ggttttcccg 2640361 agatctagcg cgtaataaat tcttgtctct gcggtatgat cgtcataaat gagcgggata 2640421 tcttcgctgg acttgtccgg gaaggaagtc gagcggatga ccggataaat gcgagtttct 2640481 ttcccggtca tttcctgagc cttcccttcc attgccgtca tcgcttcgga gacatagtac 2640541 acgatctcat caatggcttc gtcttttttc agttcccatt ttgcaataat cggcggcaaa 2640601 tcgagtgtaa tccctttttt agtcgtttga tcctcaacac ggagggtgtc tttttctctg 2640661 tcaaacagaa aggagcgatt ctcgtgctga aggcgctgct tcagtatatc tgacagcttc 2640721 cttgaggtca ttttcaaacc gatgtcctcc tttacgcttt agcgagagag tctgttaaaa 2640781 actgttcaat ttcttctttt gttttgcggt ctttgctcac aaaacgattt acttcttttc 2640841 cttcattaaa caccacaaag cttgggattc cgtaaatttc ccactctgca catgtatcaa 2640901 tgaatttgtc acggtctacg tagtagtagg tgaattcagg gaaattcgct tccagttcag 2640961 gcaggaaagg ctctacaaaa cggcaatccg ggcaccaatc ggccgaaaac ataaatacag 2641021 accaatcatc ctttaccgct ttttccagct cttgagttga ttcaattttt ttcatttcat 2641081 atccctccag ttgtttatgt tcttacatgt tttttatcga tactcgtcca tttggatcat 2641141 accaaactgc ttgaggcaaa accacttata tgcaacgaat gaatatgtaa gattggcttt 2641201 cccattatca ttatcatatt ttatttgcat tatcaagctc gtttcgttta acatcgtgta 2641261 catgagggtg aaatttacag atggatatac ataaggaggg atttttatta tggagtttat 2641321 cgtctattta gcaggagaaa tccacagcaa ttggcgcgag gaaattaaag aaaaaacaaa 2641381 atcactgaag ctcccgatta cgtttgttgg cccgatggag aatcatgacc gctcagacaa 2641441 tattggtgaa gaaattatgg gcgtacagcc aaatgccgtt ttaaaggatg acaaagcctc 2641501 tgacatcaac aacttcagaa ccgccgtcct gatgaataaa gcagactttg tgatcgccct 2641561 gtttggcgaa aagtacaaac agtggaacac ggcaatggat gcatcatatg cgatcgcaaa 2641621 aggaaaaccc ctgattatca tccggccgga atcgctccac catcctttaa aagagctttc 2641681 caataaagcg aatattacgg ttgaaaccgt taaccaagcc attaaggccc tttcctatct 2641741 atttgaaaca gaataagaaa aaagcttgtc gatccgggct tactgctcgt tcaacaagct 2641801 tttatgaaac ctacatattt tctttaatcg catccactgt ctgcttatcg caggctgtta 2641861 caagtttgat gagcatttct ttagcagcag cataatcatc aatatgaatg atagtagcgt 2641921 ttgtatgaat atagcgggaa catattccga taaccgctga cggcacaccg ctgttcgaaa 2641981 tatgaacctt gcctgcgtct gttcccccgc cggatacaaa atattgatat ggaatatcat 2642041 gcgtttcagc catatcaaga acgaattccc tcattccgcg atgcatgact gtcgttctgt 2642101 caagaatgcg cagcaaaaag ccttttccaa gctggccgaa ttcatttttg tctccgctca 2642161 tatcgtttgc cgggctggcg tcaagggcga aaaacaagtc cggtttaatc atatgagaag 2642221 ccgtctgcgc gccccttagc cctacttctt cctgaaccgt tgcacccgca tagagtgtat 2642281 tcggaagctc tttaccgtgt aattccttca gaagttcaat gcttaagccg catccatatc 2642341 tgttatccca tgcttttgat aaaattttct tttcattcgc catcgtcgta aacggacaaa 2642401 caggcacgat ctgctgtccc ggtctaatgc cgattttgat ggcgtcttcc ttatcatccg 2642461 ctccaatgtc gatcatcatg tttttgatat ccatcggtcg gtttcgctgc gcatctgtca 2642521 ataaatgcgg cggtatgctt gaaatcacac ccggaaccgg cccgttatct gtttgaattt 2642581 caacccgctg cgcaagcaaa acttggctcc accagcctcc gagcgtctgg aatctgagca 2642641 gcccgttgtc tgtaatggat gtcaccatga agccgacttc gtccatgtgc ccggctacca 2642701 taattctcgg tgcgtcctct gcgcctcgtc tgactccgaa aacacttccc agtctgtcct 2642761 gaacgatgtc atctgcatat ttggctagct cctgcttcat aaaagcacga acctgatgct 2642821 cattgcccgg cgcgccggga agctgcgtca gtgtttggaa aagcgctttc gtttcttgat 2642881 tcatgttttc ccctcatttc tatgtagtcc ttttatttta ttagaaacaa tgaagttttc 2642941 caagcactct gacccaatct gctcgatcag ccgcgtattg cttaacagga tttggctgtt 2643001 tctgtataat gaaaagtacg atcaaccagg aggtgcttta ttttgaaatt gcgtcatctt 2643061 cttttaggag caggacttgg aatttgtacg gctgtcgttg tgagacaata tgtgatgaag 2643121 ccttatattt cttcagaaaa agcgcttcga attgtaaaat ctgcttttaa gcagcggggc 2643181 ccgattgacg gatcatggat ttacacccag ccggagccct acaatattaa cggagaaacg 2643241 gtacaggtat acaaaaccgg cattacacga tcagctttcg gagaattaga acagtatgaa 2643301 gtcatggtgg atgcgaaaac gggagaaatt gttgatgtca ttgatacaat cgcctcttaa 2643361 caccggacaa gcaaaaaata gaagccgctg cctatgcagc ggctcttttt tattatatcg 2643421 cgcgaatcgg tttgtatacc ggataccaca tcgcatcctg cactgcctgt ataatgtctt 2643481 caggctcttc cgtagcgacg ccttccttca ttgcggtttt tgcaacttca acagcaacgg 2643541 ttgccgaaac agtgcgcaaa tcttcaactt ttggaagcat cggcgcccca ggcaccccga 2643601 cattgaccat acctgcgatt gcccgggcac atgcttcaaa catgccgtcg gtaattaatt 2643661 ttgattttgt aacaatcgtt ccaagaccga gaccagggaa gacaagcgcg ttgtttgcct 2643721 gcccgatatg atacgtaact ccgttatatt caactggcgg gaacgggctt cctgtcgtga 2643781 tcagcgcacg gccttctgtc cattcgatta aatcctccgg ctttgcttca gaaagagttg 2643841 tcggatttga cattggcaaa atcgccggcc gtttcacatg tgacgccatt tcttttacaa 2643901 tttcttcagt gaaagcgccg gaaaccgtag atgtgccgat caggatcgtc ggtttcgcct 2643961 gccgaaccac ttcaagaaga tcaatgcctc cgccgtctcc gttccgctga taatccttca 2644021 cttcatcagc cgaacgggca tacggctttt ggaaatcaag aagctgatcc atatcatctg 2644081 ttaacagccc gttcctgtct atgcaccaga agcgcttgta tgattcttct tcactcagtc 2644141 cctcgcgcac caatgcttcc cgcagctgtt cggcaattcc gattcctgcc gttcccgctc 2644201 cgaatataac aactctgtga tctctcagcg gaactttaga cgcttttgca caggataaga 2644261 ctgcggccaa agaaacagcg ccagttcctt ggatatcatc attgaaggta cacactttat 2644321 ctttatagcg tttcaaaatg cttcgcgcgt ttttcgcccc gaaatcctcc caatgcagca 2644381 atgcattcgg aaatgtttct ctcgccagcg caacgtagtc gtcaataaat tggtcataac 2644441 gttccccgcg cactctggaa tgctggttgc cgacataaag cgggtcgttc aagaggctct 2644501 cctgatttgt ccccgcatct aaaacaacag ccagcactct gctcggatca atgcccgcag 2644561 ccgctgtata aaccgccagc ttgccaatag aaattgcgat tcctccgacg ccccagtcac 2644621 cgattcctaa aattccttcc gcatcagttg caacaattaa atcgatcgta tcgctttgat 2644681 ctttatactg tttaaaagct tctttcatac cgtccgggtc atcgattgac agatagagcc 2644741 ctcgtggttt tctgtattca tggctgtatc tctgaattgc cgttccgact gtcggtgtgt 2644801 agacaatcgg gagcatttcc cctaaatggt catttaacag gcggtaaaac agcgtttcat 2644861 tccgatcgtg cagcgccgtt aaatagacat ttttgctcaa atcgtcaggc tgtgcggaat 2644921 attgttcata cgctcttttc gcctgatcat caattgttaa taccttgggc ggcagaaagc 2644981 cttttaaacc aagttctttt ctttcttcct cagtaaaagc aacacctttg ttcaaaaaag 2645041 gaacagagag cacttcaagg cctcttaatg ttgtttgaat gtctccttcg tttgttactc 2645101 tgaattgttt caccctgcct cttcctttct gagcataata gtactaggtt tgcattatta 2645161 gccggaaaac atgcagggta aacataaaaa tatgctatcg cttcattcgc ttaactgact 2645221 ttttgatgct tccgtcctcc tcccattgaa gggcgcgata ctcggcatca tggtaaaaaa 2645281 taaaccaagc atctttttct gctgcgaacg cctgccattt ctgcttttgc gggatagagg 2645341 tcatcggata atcatcgtaa gccagcaccc atagcggatt gcggtgggca tgtgtcggca 2645401 tcagatctgc catatgtacg gcagtttcac ccgcatcctc gcatatcagg acactgtgtc 2645461 cgtcgctatg gcctccggtg tgatgcattg taataccctc tgtgatcgtt aaggtgtctt 2645521 caaaggtttt gacttggcca gctacagcct cccaattttc tttccaatac gtatttttcg 2645581 acctgatatt cggatggcgc atttcgtccc attcaacagc tgatgtataa atcactgcat 2645641 tcggaaagac agagacgagc cgttcacctt catattccgt taaaccgcat gcatgatcaa 2645701 aatgaaggtg tgtcattgcg atcacatcta tatcggcaac cgttaatccg agtgcagcta 2645761 atgagggttt cacattcgac tcttgtgtca cgccatagtt tcgtttttgt ttatcagtca 2645821 gcttgccgta cccaattccg gcgtcaatga tgatattgag cccatccttt tgaatcaaaa 2645881 tagggtctgt tcttagttca atctggtttt tttcattgac tggatatttt ttagaccaaa 2645941 gcggctttgg cacaacgccg aacatggcgc ctccgtccat atgcgtcacg cctccgtcaa 2646001 gccaggtcaa cgtgatgttt ccaattttca ttgtttccat tttcaccccc ccctatcatc 2646061 atggtagcaa acggcccata aaaaaaacag actcctgtca gagtctgtct ttacgttctc 2646121 cattcaacct cagcccgata gatcggctgg ccgagtgcag agaatttttc ttcatattct 2646181 gtcataatat tgccttccag attgctgtta tgcaaatcga gactgacgta tgtcagcagg 2646241 aggccgtact cagagaagct cttcaaagag tactcaaata aacctcggtt gtccgtttta 2646301 aaatgaatcg atccgccttt gcccattact tcttcatatt ttttgaggaa gtgggaatat 2646361 gtcaggcggc gtttttcatg ccgtttcttc ggccaaggat cagaaaagtt caagtagacc 2646421 cgtttcactt cccccggctc aaacacatcc gtcagcgtgt ccgcatctat attcagaagc 2646481 tttacattct gcgcttcgct gtcttttact ttttggacgg ctgtcacgat gacgctttta 2646541 aataactcaa taccaatata attgatgtcg ggattttgtt tggccatacc agaaataaat 2646601 tggccttttc ctgtaccaac ctcgatatgg atcggattgt cgttgccaaa cactgtgttc 2646661 catttccctt tataatcagc aggattgctg atggcaatat ctgcgttttc agccaaaaag 2646721 tcatcagccc aaggcttgtg gcgcattctc atatgattga cacctctatc tattatttcg 2646781 actaacaaca taccatgaat taaaaagacc cgcaagctcg tttttccagt gtatctctct 2646841 taaggccgag cgcataaaaa aagagggtcc cgtctgctgg aacactcctt tcccatgtat 2646901 aaaaacgctc tgttttgaac aatttaaccc gtatgatact gaagggatgt gtaccgttat 2646961 gggtttacat tatgagcatc aagttcattt attgaaggat atattgactg accatcaatt 2647021 ggactgctgc ggaacagtcg cagagtacga gcagcttgag cgtgtgatta aatcactgat 2647081 ggcaaacacc gagcttgatt caaatttcaa aaacgtgctt gaagatgttt accgctacag 2647141 ccaatcagga atatcgtcca aatccatcga ctcacacata caagagcatc agaacagcct 2647201 gtctcaatgg gtagagcaaa tggattcgta ttcctgatta atcaacaatt cgtttcatga 2647261 ggatatgcag ctcttccatt gcatcatgaa attccttatc attgcctttt gctttatgcc 2647321 aggcaatgaa agtaattgtt tcagataaca cataccaagc cattcgcaac cgaaggcttt 2647381 ctgtcagctc tatgccgtac atgctcagcc agctctccca agctggcttt tcgacgtagt 2647441 ggtacagcaa aggcccgagg tccatcgccg gatcagcgat catggcgccg tcccagtcaa 2647501 ttaaatacag ctggttgtct tcagacaata gccagttatt atgattgaca tcacaatggc 2647561 aaacgacttt ctcaccgaaa tgcacttcat gcaggtgttc ttccaaatac ttgatccctt 2647621 cttgaatcag cggcgaagat tgctgcacag caaatacagc ctgcttcagc tgagacaaaa 2647681 gagcccccgg gttcagcggt tcttttccaa gtctcttcag catgtccagc aaggcttttg 2647741 atgtgtgtat tttacgaagc aattcagcaa cgggccgtcc gctcatgtct ttaggcttca 2647801 gctctctgcc ggtcatccag tgctgggccg taatgacgtc cccattttcc atccgttttg 2647861 tccaaaccag cttcggaaca atgccttcgg cggataaaac agctaaaaaa ggtgagctat 2647921 tacgttttaa aaaaagctgc tgcccgttat gtttcgcata atatgcatct cctgtagctc 2647981 ctccggcggg gaagatctcc caatcgctac ctagtaattg tcccaaccag ttcatatcaa 2648041 tgttcaaccc atcatttctt aaaatatttt agaattaagg ctaatcgttt ctagtctatc 2648101 cagcgaatgc ctttttcgta cgaatcgtat aaaaataaaa aagacagcta ttgagagtct 2648161 catatgctaa tcaatagccg tcctttaaat tttagcgcta tagcacaaac ttcgtcaagc 2648221 aaaactctta agatctgatg ctaaatataa gataaccgtt ccgatgccgt ttactgcaac 2648281 cgttttcttg atttctgttg ggtcttcctg aaatcctgat ggatcacata aaagccgata 2648341 aggtatgtcg tttggcagcc tccactcgac ggagtctgga ctcgcgtgat ggataacaat 2648401 gatatctttc cattcgtcaa cctcgtcaag atcataaagc ctgtatgcga taaggtgttc 2648461 ttttagcgtc aagcattcaa gatggcgctg gatgtctgca gcggacctaa gacggaatgc 2648521 aggatgcgct tttctcagcg agatcagcct gcggatatag tgaacatctt ctttgaatgt 2648581 ttcacggcga tcccagtcga gctggttgat gctgtcactg gattgatagc tgttttccac 2648641 tccctgcttc gtccggaaaa attcctggcc gctgtgaata aacggcaccc cttgggcaag 2648701 caaaataatc gcggctgcaa gcctttgcct gcttcgcttt cggctgtcat tttcttgagg 2648761 aagcgcaaag ctcattttat cccaaaaggt gtgattgtcg tgtgattcga cataattgat 2648821 ggactggctt ggttccggaa caatcggtgc taatgccttc catccggaag acccggcaat 2648881 tccatgcatc acagcttgtg ctgattcacc gttgccgagc gcaaaccctg ttgccttaag 2648941 gtgaaaggtg ttccctttta cagcgtcacg aaacatatca ttaaaaaagc cgatgcccgg 2649001 cattcttggc gcgttcgcca aagcagcttt ctgttcatgc ggcagcggtg tagccaggtc 2649061 ccacccttct ccaaaaagca ggattccggg ctttgcctta gttgctttct ctttcatata 2649121 aagcacggtg tcaatatcta aaatcccgag gagatcaaag cggaagccgt caacattgta 2649181 ttcttcaagc caatagacca cgcaatccgc aatgaatttt cttgccatcc ttctttctga 2649241 tgcaatatca ttgccaacgc cggtgccgtt tgatggcatc ccacattcgt cgtgccggaa 2649301 aaaataaccg ggcactgtct tttcaaaggg ggaattctcc ctcttataca catggttaaa 2649361 aacaacatcc agaatgactc gcagaccgtg ctgatgcagg gtattgatca tttgtttcag 2649421 ctctgttttt ctcgtttgag gatcatgagg atttgaggca tagcttccct ccggggcaaa 2649481 gaaatgaagc gggttatatc cccaattgta tgcatcaagc ggcttctctt catcaactcc 2649541 ggcaaaatca ttcaccggca gaagctccac atgtgtcaca ccaagctctt ttacatacgc 2649601 taatcccgaa gaactgccat ttgcggtttg tgtatcagtt tccgtcagcg ctaagtattt 2649661 tcccttgttt atcatgccgc tgttttcatg gatggagaag tcgcgaagat gcgtctcata 2649721 gatgacggca tccacagggt gtgagaatgg tttaagagga gcagtccatt tcatttgatc 2649781 cgggcgcaag acgacgccct tctctccatt tacagtcaca gccttggcat actggtcaac 2649841 tgtttccatc cattctgaat tgttgcagat gcaaaacaaa tactcatatc cgtgaaggtc 2649901 acctgtgacc gtgacggcat agacgccttt ttccaagcga gtcatttgga atgtgcgccc 2649961 gcttttattg gggtgtgaaa gcttgacagc agctgaggtt gcagcaggcg cccatacttt 2650021 aaatacggta tgatccgcgg tataaacggc gcccagctct ccgtcataat aaaattcgtc 2650081 atcaaacgct gccgtccgga tgaccgcgcc aatttggaga tccgttttgt ggccgctgga 2650141 tgctctgacg caatggattt ttccaaatgt cacaggatgg tcggatacgc agacgtactt 2650201 gtattttgct tcaagggagt attcctccct gacagccaga ggaaaatctg ttatttctgt 2650261 ctcaagccga aacggcggtg tcatgatttc cttttgttca gcaggaatca gaacagtaat 2650321 gatattcatg tcatcgacat acgcttcgaa gctgcggcgg atgctgacca tcggaagctc 2650381 tctcctccaa acacgtttat gttttgattc ttaggggtga aggactagat gccagacgaa 2650441 acggggtagt gcccatgatt tctccgtcag catggaacgg gattttgtcc ttcgtgtaaa 2650501 atgtaatgtc cttcgcttta aacatcgtaa cgccatccat ctttgtatgt tttccaaatg 2650561 ccatgagaca taaaagccaa tattttttca aaaacggctg gttttcaacg attacgatat 2650621 caaatgtctt ctcgcgcgga tttgctaggg gcgccgcctt catgcctccc ccgtaaaacg 2650681 gatggttgga tacaacggca aaccagacat catgaaattc gcgcgtctcg tcttccgtcg 2650741 tacaagctaa tgtaaacggc ttaaaggttg ccgaagcgtg caaatgagaa agcggataca 2650801 caagaaatcg aaggcggaga aaaagaaaaa cccgtctcaa cggaaattcc atcgcctttt 2650861 tattgacata tgcgtcaaac ccgatcccga tatgattcat aaaataaaga atctgtgatt 2650921 tatcctgaag gaaattgacg ctccctaaat gaaaggttct tgttaacggg cgctttacct 2650981 tcttgatttc ctgtatcaga tcgatttttt taatagagaa ccctcgcgaa aaatcattat 2651041 acgcgcccgc cggcacaaag ctcagctcaa tatcgtcaac atctttcagc ccgttgacaa 2651101 cttcatgcat ggttccgtct ccgccaatga cgatcaggcg cttcagctta tattcctgta 2651161 tcgttgaaat ctgtctggcg agcacctcgg cgtgtcccgg atgttcagtt aaaaatgaac 2651221 ggtgctcaac ctttcgtttg atcaattctt tttgaatgga cttccaaaca cgcaggccgt 2651281 ttcgatgtcc tgctgtcgga ttaataataa aaaaccaatg gctcatcttt ctcacctgct 2651341 tatgttatga gaaaaccgct caaatcgttc tcttttactc cagccactcc tgtctgcgat 2651401 aggagtcaga catgcagtaa gacaatagag cctttgcagc ctttacctga tgatgtttga 2651461 tcggagcagt gtttttcttc tgccgctcaa tccattcttc cgcgctccgc ttatccgcta 2651521 tttctaagcc gtatggcggc tccgggtaat cgatgtacga cgttctgctc agaagcaatt 2651581 ttcgaaccgg aatctcagcc tgtttttcct ttacgatctt tgacacaacc gagtccgtac 2651641 gaaacaggct aagccctgga tttaacactg atgcagtctg agaggctgtt ttcttgtccc 2651701 aaaaacgatt tttagaccct atgtagacac tgtcttcctc agcctctaaa aaagaaacgc 2651761 aataaatttc cagaggagaa ataatcacaa tgcttaattc aaccgccgcc tgctgaattt 2651821 tcagcacagg cttatacata ataaaataag aatcaggcag ctgctgggtc agataacgca 2651881 aaatgcggtc ctgcttcact tggtttgaga gttgagatat ttctgaaaga gtagagcttg 2651941 cccatttgag ctgaaaatca tataaatgcc ttttataaaa agaagcaagc gccaccctgc 2652001 tcttcgggag ccttacatga atatcttctt cgtcctcaaa ccattggtgt ctctcttctt 2652061 gtatatcggc ttttatctct tcttttcttc ttttcaatga aaattttttt cgtttctgca 2652121 ccggttccgg ttcttcagca ctggcttgcc tttcttcatg ctggcgctcc gctgcttcta 2652181 ctagtgaaag ccagcgctct tttttcaaac gtacaaactg gttgatataa tggtacggat 2652241 caagctcata tctcgatata taatcatgaa ttttgatgat ttgtgccatg tttgtttctc 2652301 cactccgcaa tgaattaaga taattgaaat ttgaatattt cctcgtattt tggtgattgg 2652361 ttcaagtgta tttgaaagag cgaaaatcgt tcagccatca tcgaaacctc gccgctttca 2652421 aacggaacat gagctggaaa tccatcttcg cctgtccatt ttcttgccag cgtcatatga 2652481 ggatgatacg gtcttttttc cacttgaaag ccggcctgaa gtacagcctg cttcgtatgt 2652541 tcccgcagtc tatcaagcgt tttgtttttc tttggctcca gatgtaaaac gcgcggcttt 2652601 ctgcggtcgc cgaatacatc tatcttgcca aacttaattg aaaatggatc aatttctgaa 2652661 gcaatctctg ctagcgaacc ttcaagcttc tttatttgtg tctcatccgc cgctccgaga 2652721 aaaattaacg tgatatgata gtcaagcggg tgcacccatt tttgaaacgt caatatcggt 2652781 tcgtttttcg cagcctggta gatcggattt gcaattccct caggtatggg aacgccgatg 2652841 aaataatgag gccgtatatc tggcatccgt ctgacactcc cttctttgac agctattatt 2652901 ttatcaataa agaggctgtg cggatagagg aacagtgtat gaaaacactc tcgcacaaac 2652961 gtttattatg ttaggatatt atatgacact tgttttattc agaaaggaat gacaatgttg 2653021 aaaatcgttg caaacacagc tgatctgata ggagatacac cgctagtgag attgaatcgg 2653081 cttcagccgg aaaatgcggc acaagtctat ttaaagcttg aatttttcaa tccgagcggc 2653141 agtgtgaaag acagagccgc ttatcaaatg atcatagaag ctgaacaaaa cggtttactc 2653201 aagccgggat cagttattat agagccgaca agcggaaata ccggcatcgg gctcgccatg 2653261 aatgcggcag cacgcggata taaagcaatc ttagttatgc ctgatacgat gacgaaggaa 2653321 cggatcaacc tacttaaagc ttacggtgca gaggttgtat taactcccgg agaggaaaga 2653381 atgccgggca gcatcaaaaa agcgaaggag cttgccgaac aaattccgaa cagctatatt 2653441 ccaatgcagt tcgataacac tgctaatcct gatgcgcacc gaaaaacaac agcgcctgaa 2653501 atcgcccggg caatagagga aatcggaaaa ccgctcggcg cttttgtagc ctcctctgga 2653561 acgggcggaa ccattaccgg aacaggtgag gcgctcaaag agctttttcc ggatatcacg 2653621 gttcatgttg ttgagccagc gggttcgcct gtattatccg gcggaaaacc tggcgcgcat 2653681 aaacttgtag gaacgagccc aggctttata ccgccgattt taaatgaaga cgtttatgat 2653741 gaaattatca aaatctctga tgaagacgcg tatacgacga caagacggct tgctgctgaa 2653801 gaaggaattc ttgtcggtcc ttcatcaggc gctgcctgct tcgcggcaat cgaaacagcg 2653861 aaacgcctct ctcctgacaa agttgtggtc tgcatgacag ctgatacagg agaacggtac 2653921 ttatcaactg atttatggtc atttatttaa aaaaaggact ggcttcagca gaagccggtc 2653981 cttttatttt gcaagctcgt aaatggcctg agcatataac gctgtcgatc tcagcaggtc 2654041 atcaatttcg atatattcat ccttttggtg tgcgctgtca gggcgtccgg ggaacagcgg 2654101 gccgaacgcg acaccggctt ttaaggatct cgcataagtc cccccgccga ttgagattaa 2654161 atcagctttt ttacccagct ggccttcata aaccttttgc agggttttga ctaacggatg 2654221 atctgcggac acgtgatgcg gcttgctgtc tttgaattct cccagctcaa attcagatgc 2654281 gctttcgaat gtatcgcgga tcactttgct ttctgctgtc acaggatagc ggatattgat 2654341 cccgagctcg cctccttgcc cttctttata gcgcagtgtt ccgacattta atgtcagctc 2654401 tccgctgatt tcatcctcac agtcgatgtc cagttttttt cctcttgtat cacctgagaa 2654461 cttatctgtc acaacttgca caaaccgctt tcctgcatcg tcaagctcag tctgctggag 2654521 aaattcgcac aataaaatgc cggcattgat cccattgttc ggttccatcg catggcagga 2654581 aagaccgtac atacgcaaaa tgagctgtcc gttctctatt gcagcttccc ctttttggtc 2654641 cgtcgtgcgg agcatgtctt taaatgaaga cagaatctct tcatttttcg gcccttcaat 2654701 gacagcttcc gcagcgtcgg gcaccatgtt taagcgaagg cctgattgaa acgagacaag 2654761 cactgccttt ggttcagctt gatttgggcg gtgcggaata agtaaagaag catcgatgat 2654821 ccctttttcc gcattaatga tcggaaaatc ggcgtcaggc gcaaagccca ttgttggcat 2654881 ttcttcatgc ttgaaataat gctctacgca tctccaatca ctttcttcat ctgttccgat 2654941 aatcattctg actcgcttgg acaggggcaa attcatgtct ttcacgattt tcagcgcgta 2655001 gaatgccgcc attgtcgggc ctttgtcatc aatggcgccc cttgcataaa tccgtccgtt 2655061 gcggatttca gctgaaaatg gatcactcgt ccacccatct cccggcggca cgacgtcaac 2655121 atggcaaagt acgccgataa tgtcatcgcc ctccccccat tcaatatgac ctgcgaagcc 2655181 gtcaagattt tttgttgtaa agccttcttt ttctccaagc tccagcaatg aagtcaggct 2655241 ggcatttacc ccttctccaa acggtttacc gggtccggcg gttgtttcgt ccatgacact 2655301 gttgattctc aaaaattcct gtgtatcacg aattaaatcc tctttttttc tgatcacttc 2655361 aacttcccag ttcataatga tcccctttcc gcaagaaatg acttgcaaaa accaaataaa 2655421 acgaataata ttaatggtgt tttgttaaaa cgttcgtaat tggaggatac tatgtttcat 2655481 ctaaaagagc agcaaacatc cataaagcaa gaaatcatag cagggctgac gacctttttc 2655541 acaatggtct atatcgtcgt ggtcaatccg gtcattctgg ctaacgccgg ggttcctttc 2655601 gaccaggttt tcaccgcaac gattattgcc tccattgtcg gaacgctgtg gatggccctg 2655661 gcagcaaatt atccgattgc tattgcgccc ggcatgggct tgaacgctta tttagccttt 2655721 catgtcgtaa gcgcaagcga tggcggcatc acgtacgcaa cagctttcag cgcagtattt 2655781 acagcagggg ttctcttcat tattctatcg ttaacgcctt taagaaaaca acttatagaa 2655841 gcgattccaa acaatttaaa atacgggatc acaacaggga tcgggctgtt tattgctttt 2655901 atcggtttgc gtcaagcggg aattgtggca gctgatgagt caaacctggt cactctcggc 2655961 aatctgcatt cacctggtgt tatcttaacg ctggtcggcc ttttgatcag cgtggtcctg 2656021 atggtgctga atgtaagcgg cgctttattt atcggaatgg cagctaccgc tttgatcgcc 2656081 tttttcaccg gtcagctcca tttttcaaag ggatttatgt cgcttcctca tttgccggaa 2656141 ggattgatga tctcaaatcc atttaccgct tttggcgatg tcattcatca cggcctgtac 2656201 gctgtcgtct tttcttttct attagtcacc atttttgata cgacaggcac gatgatcgga 2656261 gttgccgagc aagccgggct gatgaaaaac aacaagctgc cgaacgtgcg aaaagcgctg 2656321 cttgctgatt caaccgcgac gacagtagga gctgttttcg gcacaagtcc gacgactgca 2656381 tttatcgagt cttccgccgg tgtcgcagcc gggggaagaa cggggcttac ggctttgact 2656441 gtcgcggtga tgtttgcggc ttcaatgttt ttcagtccgc ttgtcagcgc cttgtcaggt 2656501 atagccgcca tcacctcgcc tgctttgatt atcgtcggca gcctgatgat gggctcagtt 2656561 tccaatatga actggaaaga gatggacgag gcatttcctg cgtttctcgt cattctagcc 2656621 atgcctttga cctcgagcat ttctacagga atcgcgcttg gctttatttc gtacccaatt 2656681 gtaaaagcgg cgcggggaaa atggagagag attcatccgc tcgtcatcgt tttcgccatt 2656741 ctgtttttca tccagctgtt tattttataa ggatagacca aaaaacccaa acgtcgccgt 2656801 ttgggttttt tatgtaaaca ataaagagac agcggccgct aaaaaacaac aggcggcaaa 2656861 cgcatagtgc aggatgttga tacagctttt tctggcccga taatattcat cactttcctt 2656921 atcggtgcca attaaaaaag gggcatccat gaccttgtca aaaataagcg tcaggatata 2656981 acggcaaacc cctgtgtata ccagcagcgc aatcaccttc agccaaattg gggaaacaaa 2657041 tatgagaaca gtgaaagctg acagtagcat gtacatctgc cttgcatact cgccattcct 2657101 cagcataact ttaaaaaaca actccttata gcctgtgcag atcgttcgtc ttttaaatat 2657161 cctttttgaa tttcggtata ataatggttt tcttctcatc ctgtctttta cttttggcat 2657221 tcccgcctcc tgactcatca tcatcacaag tcctgcaagg gcaagcctgc tttttttctc 2657281 ttcagtcacc tcagcttcaa aagccgtgaa cgaggctgtc tttttcaaac tgcggataac 2657341 tgagaaaaac aaaaataaaa tgccaaaaag cgcaagcaag tgccgctcag taaaaacaat 2657401 caggatagca gaaccagcaa aaagaatagc tctgacaagg gtatcgccaa tccatctcga 2657461 aatggagcgc ggctttctga tcctgtcttg ctttaaggat aaaaagaata tatgaaggcc 2657521 aaacaaataa cacaatagag cagtgctttc tgcgaatgtg atgagaacag aatgactgat 2657581 caagggaagg acaatgaaaa agagaagcag ccatttagcc agcgtggcca gaaaagaata 2657641 caaaagcgca taccgtttga gctgatagat gatttccttc ttttgcagca aaaacacttt 2657701 gtccgcttcc attaaaaatg tacgaatcga acctgtaaac atgatcagca cacacacagc 2657761 atacagccat ctccattccg ccacttcaga ccactcataa agaaggcctc ttccgttcat 2657821 caaatcaata tactgataga tgacaaaagc aatcgccggc aaaacgatat agagagcgac 2657881 tgtccagtca atgaccgcat gcaacacttt aaactgatac ttataatagt caaacagcct 2657941 tcgaaaaaag agcgtacgcc cgttcatagc cgatcacctt gaactgcctt ataaaaacag 2658001 tcaagcaatg actgcccctc taatccggtc ttgtcctgaa catcttttaa cgtgccttgg 2658061 agaaataatg aacctttctc aatcatataa aaccggtcac agattttttc cgcggtatcg 2658121 agtacatgcg tgcacataag aattccggct ccacgttctt tttcagcctt aagcatgtcc 2658181 acaaagcgtt tcgtcgatat cggatcaagg ccgataaacg gttcatcaat cacatacata 2658241 tccggcttag agagaaaggc ctggataagc attagttttt gctgcatgcc cttcgaaaag 2658301 gtgacaggca gctcatgttt gacatgatct agcgaaaacg tctgcagcag gctttgggcc 2658361 cgatgcgcaa attcactctc ttcaatgccg tgaagtgtgc tgatcagatc caaatgctcc 2658421 cacagcgtca gttcttcgta gaaggacgga tgctccggaa tatatgcaaa tgaacagtcg 2658481 ttccaggcaa tatgcccttt aaaatcttct gaaaggccga gtatcgcctt gattgcggtg 2658541 ctttttcctg cgccgttagc tccgatcagt ccaaccagtt ccccttttct gacttccaga 2658601 aaaacatcgg tgagcacttt ttttcggctt gtatacccgg cctgttctat tgaagcttca 2658661 agcaaatttg tcaaaactca ctcacctcca aaatttacta cgaaatagaa taaaaaaagt 2658721 ttctttaacc ataataatat tgagccgaaa tacatagtaa tccaacaagg atggctgccc 2658781 aacgcgaaat tggaaaaaat taataggagt tatccctaga ttcatcactg caatatcgtg 2658841 tataatgagg gcgaattatt ttaacaatta cagatgtctg cctttgttgc tatttcgtac 2658901 gcagttgata gtcgtgagtt gtggttagtc aagtccatcc gatcttatga tagggagtgg 2658961 ttttttgaaa ccttcaacaa accgtatgct aactcgaatc aaatcagttt acatgtttat 2659021 tcaagaaaaa ggtcttgtga caacacagga actggttgac gaattcggca ttacacctag 2659081 aacgattcaa agagacttaa atgtgttggc atataatgat cttgttcata gtccaagccg 2659141 tggcaagtgg gagacaacga gaaagaaagt aaagattacc tcataaattg aaaattacat 2659201 agggccgcct gagagcggtc cgatagataa cagggcgaag aaactactga gccttgtttt 2659261 tgtgtgctta taaataaaac cccgcattcg gtatgcgggg tttttgtcat gcttgcggct 2659321 catttagcaa atgaagctct tcctctgtca gctcacggta ttctccgggt gccagagcgg 2659381 gatctaggga aacgcgtccc atcgaaagcc gcttcagata aaccacttca ttgccgactg 2659441 cctttgccat ttgcttgacc tgatggtatt ttccttctgt aattgtcaga tatataacgg 2659501 tattgccact gtcgtttgtt ttgatttccg cttttgccgg ctttgtttta tagccgccct 2659561 ctatgtagac acccgtttcc aaatcggaaa tgtcttcccg agaaatctgt gattttaaat 2659621 ggacttcata cgtttttgga acatgctttt taggagaaag gagccgatgt gcgagctggc 2659681 cgtcatttgt gagcagcaaa aagccctctg tatctttatc aagcctgccg gctggaaatg 2659741 gctcaaatct catctcctcc ggcgtcagca gatcgaccac tgtttgctgc cggctgtcct 2659801 cagtcgccga cagcacgccc tgcggtttat tcatcataag ataaatgaac tctcgataat 2659861 caaccggttc cccgtatacg gtcacctcct gcgtatcagg atcaacgtgc tcctttacat 2659921 ctttggcagg tttgccgtcg atcatcacgg ctccagcctt cacaacggct ttgacttctt 2659981 ttctggaacc atacccgctg ttggcaagca gcttatcaag tctcattccc aatctctcct 2660041 ttataaaaga aagcccgcag catgcgagcc ctcagtttca tcatatctag ttcatcagcc 2660101 tgcatgtctg cctttcctaa agaaacctgg caaacggcgg cctaaaattt tctgcaaaaa 2660161 tcctaatcgg tagccgcaat acaggtagac agctccgcca acagcggccg cgatcaccac 2660221 aacaatcgca gcttgcatct ggccatcctg ataggaaata aagaagccta atacccactg 2660281 cacgattttc acggcaatac ccataatggc tgataagacc agcatcaaaa cagttcgttt 2660341 aacaagtatc ttatacgaat agcctgcatg gcgcttaatc atgataaacc catataaaag 2660401 ggaagcgata tatccaagcg ccgtcgctaa aatcgctccg tcagcctgca tcagcttgat 2660461 cagcggaaca ttcagcacaa gcttgatcac gacaccgatc acaaggctga caaccgcaaa 2660521 tttttgctta ttgatgccct gcagaatagc tgcgttgact gtaaacaaag agaacagaat 2660581 tgcgacaggc gaataccaaa gcaaaatgtt tgcccccagt tcaggatgaa ggctctctga 2660641 cccgtaaaag aacgtatacg tcggtcctga caatagagag atcccgacaa cagccggaat 2660701 aattaaaaac aggatcgtct gcatcgtttg attaatctgc tgatttaaca gcttatagtt 2660761 tccgcttgta aacgattcag taatcgttgg aattaatgtc agtccaaaag cagttgctag 2660821 ggaaaccggg atcatcacga gcttctgaac atacagggtt agaatcgcaa gcatgtcctg 2660881 gctgatggct tgatgaccgg cttcaatcat cgctttgtta aacgtatttg tatcaatata 2660941 gttatacaaa gggatggcta gtccgacaaa aacgtacgga gcagcatagc tgaacagctc 2661001 gaaaaacatt ttcttgtagc ttaggtttgc tgtcggaccc gtattcggca tcatcgccag 2661061 caggctgccc ttccgtttgt tccaataaat ataaagcacg accagccctc cgaaggcacc 2661121 gatcagcgct gcgaaggttg catagcccac agcgatgaca aggccgccgt tgaaaacctt 2661181 caaaatcaag aatgtcgcac tcaatagaaa gatgatgcgg acaatctgtt caacgacttg 2661241 ggaaacagct gtcggaccca tcatttggtg cccttgaaag aatccgcgga caaggctcat 2661301 aatcggtacg accaaaagcg ctaagctgac catgcggatg acataaacga catgatcaat 2661361 tgtcaggccg ttattatcct tgcctcccag cgatatttcc gcaaacatcg gagccgatag 2661421 atacagaatg aaaaaggcta tcattcctgt gactagcata accgacatgc ccgccttgag 2661481 cattttcctg cttgtctcat aatccccttt tgaattatat ttggaaacaa atttagaaac 2661541 agcggccgga aagcccatcg tagcaatatt caaaaataaa gtgtattggt tgtatccgta 2661601 ttgaaataat gcaccgcctg tcgccccgac cataatgctg aagggaatta aatagaccat 2661661 ccccagaatc cgcgatatat atgtaccgag cgttaataca aacgtgcctc ttaacagttt 2661721 gcttgacatg tttcttcatc accattttct acgaagattc aacttttcta ttttaccaca 2661781 actgggcatt tagacggtaa taaatacaaa agcaatcctg tgaacattca tgtccgcggc 2661841 aaaagacgtt taaggagcgg ctttctttcg ctataatagt actgcggacg ggtgtccgca 2661901 cacgaaatga aaagaaagtt gatgataaag atgaaacaat atgacgtaat cgtaatcggc 2661961 ggaggccctt caggcttgat ggctgcgatt gcagcaggag aacagggcgc tggcgtgttg 2662021 ctgatagata aaggaaataa attaggacgg aaactcgcga tttccggggg cggccgctgc 2662081 aatgtgacga accgccttcc tgtggaagaa attatcaagc acatccccgg caacgggcgt 2662141 tttttataca gcgcgttttc tgaatttaat aatgaggaca ttatcaagtt ttttgaaaac 2662201 ctcggcattc aattgaagga agaggatcac ggccggatgt ttcctgtgac cgacaaagcc 2662261 caaagtgtcg ttgacgcgct gttaaacagg ctaaagcagc tccgcgtaac aatcagaacg 2662321 aacgagaaaa ttaaatctgt tttatatgaa gatggacagg cagcagggat tgtgacgaat 2662381 aatggcgaaa tgatccatag ccaggcagtc attattgctg tcggcggtaa aagcgtgcct 2662441 cataccggaa gcacgggaga cggctatgaa tgggctgaag ccgcgggcca taccataaca 2662501 gagctgtttc cgacagaggt tcccgtcact tctggcgaac cgttcattaa gcaaaaaaca 2662561 cttcagggct tatcactaag agatgtagcc gtcagtgtgt taaataaaaa aggcaaaccg 2662621 attatcacac ataaaatgga catgctgttt acccatttcg gcctctcagg acctgccatt 2662681 ctcagatgca gccaatttgt cgtaaaagag ctgaaaaaac agcctcaagt gccgatcaga 2662741 atcgacttgt atccggatat caatgaagaa acgcttttcc aaaagatgta taaagaactg 2662801 aaggaagcac cgaaaaaaac cattaaaaac gtgctgaagc cttggatgca ggagcgctat 2662861 ctcctattcc tgctcgaaaa aaacggcatc tctccgaacg tatcgttttc tgagctgccg 2662921 aaggatcctt tcagacaatt tgtaagggac tgcaagcagt ttactgtcct cgcaaatggc 2662981 acactgtcgc ttgataaggc atttgtcacg ggaggcgggg tatctgtaaa agaaattgac 2663041 ccgaaaaaga tggcttctaa aaaaatggag gggctttatt tttgcggtga aattctggat 2663101 atccacggct acacaggcgg atacaatatt acctccgccc ttgtcacagg caggcttgca 2663161 gggctaaatg ccgggcaata cgcccgttct taatcattac tctttaaatc tcttgccgcc 2663221 aaactcacat ttgaacattc cccgcattca tgttagggtg agacttgttt tgtttcacct 2663281 gattgcgggg taattttaag agaggaatga gctgccatcg tacgaccata ctaagcctgc 2663341 gagcaagata taggcgtaca caaaaaatta gagggtgaga aatgttgaaa catatatcta 2663401 gtgtattttg gattgtgatt gcaatcacag ctgcagctgt attatggggt gttatttctc 2663461 ctgacagcct gcaaaatgtg tctcaatcgg cacaagcatt tattaccgat tcatttggtt 2663521 ggtattatct tttagttgtc tctttgtttg tcgggttttg tctctttttg attttcagcc 2663581 cgatcggaaa aatcaaactc ggaaagcctg atgaaaaacc ggaattcggg ttattatcat 2663641 ggtttgccat gctgttcagc gcaggcatgg gaatcggctt agtattctac ggtgcggctg 2663701 aaccgatcag ccattacgca attagctctc catcaggtga aacagaaacc ccccaagcct 2663761 tcagagatgc actccgctat acgtttttcc actggggttt gcacgcttgg gccatttatg 2663821 ccattgtggc attatgcatt gcctatttcc aattccgcaa aggcgcaccc gggttaatca 2663881 gcagcacact gtcaccgatt ctcggggata aagtaaacgg accgatcgga aaggccattg 2663941 actgtattgc agttttcgcc actgttgtcg gggtgtcaac aagtcttggt cttggcgcaa 2664001 cccaaattaa cggcggtttg aattacctgt tcggcattcc gaatgcgttt atcgtccaat 2664061 tggttttaat cattattgtg acagtgctct ttttactttc tgcgtggagc ggactcggaa 2664121 aaggaattaa gtatttaagc aacacaaaca tggtattggc cggattgtta atgttgttta 2664181 tgctcgttgt cgggcctaca gtgctgataa tgaactcatt tacagattct atcggacaat 2664241 acattcaaaa tatcgttcaa atgagcttca gactgacacc gaacgatcct gaaaaacgcg 2664301 aatggattaa cagctggacg attttctatt gggcatggtg gatttcctgg tctccatttg 2664361 tcggcatttt catcgcccgt gtatccagag gccggacgat ccgcgaattt ttaatcggcg 2664421 tcttggtgac accttgtatt ttgacatttc tatggttctc cattttcggc gtatcagcca 2664481 tggatctcca gcaaaaaggc gcgttcaatg tagcaaagct gtccactgaa acgatgctgt 2664541 tcggaacact tgatcactat ccgctgacaa tggtgacatc gatccttgca ttgattctga 2664601 tcgcagtatt ctttatcacg tcagctgatt cagctacatt cgtgctgggc atgcagacgt 2664661 cgtacggttc tttaaatccg gcgaattctg tgaaactcag ctggggtatc attcagtccg 2664721 ccatggcggc tgtgctccta tattccggag ggcttgccgc tttgcagaac acagcgattc 2664781 tggcagcgct gccgttttct atcgttatcc tgctgatgat tgcctctctc tatcaatcgc 2664841 tctcaaaaga aagaagagag atcaaaaaag cggagaaact cgataaacca agaagtccaa 2664901 gagtgaaaaa agcatattaa caaaaaagat ctttccgcgc ctgcggaaag atctttttat 2664961 ttgcgatata aaataagggc ggaaaaacag taaagctgct cgccgtctgg gtcgcacgcc 2665021 gccgaaaccg tatatttgat atctatcagc tgctcctccg atatcccttt taaaaatgaa 2665081 ttgatttccg tttgtaagtc tttttcatgc tcttcatcaa ataccgctac cttcagcatt 2665141 ttatccgctc tcctttctct atcaatctat tccgtttgga acagcgttat gatagagaaa 2665201 tgatgattat ctcgtttccg gataaaaagc tttccgtata tgggatttcc tctgtggctc 2665261 gccgccgtgc tgctccactt tcagcagcac ggcataaaca atgcgcatat ggcagtagct 2665321 gataaggctg acgctgaaaa aagggacaat gcccggcagg tacgcaagca agaaaaagag 2665381 agcaacagtc agcgcaagca tagtaagcgt atattgcaaa tacgccacac tgagcaagag 2665441 cgaaaatttc acatacagac gttttttcca gtcaaaatgg acaagcagcg gaaacacata 2665501 aaaaagcatg gatacgaaca aaaagccaaa tatcataatg gcgaagcgca ggatgtgcag 2665561 aaggaaatga cttggataaa ttaaggccaa atcaatataa atgatcactc cgatgagcgc 2665621 cagtacagcg ccgagcagat ttgaacgaaa aaattcaccc ttgtattcct gccaaaacgt 2665681 tttgagcacc ggaacgttgt cctgcccctg gatccacttc cgcatgacag cgaataaagc 2665741 cgcggtcgcg ggcatgatgc caaacacgcc gagaccgagc aacgtaaaaa acagccacag 2665801 caagtttgta tacgcaaatc tcataatcca ttcgcaaaaa cgcagcatcc gtcccagtga 2665861 gccatcatgt tccatggcgc cccctccttt tttgcattat acattctgca tctgaaaaag 2665921 ctctttcatg ccgatcggct tcttttcggc aaccgagcgc cacattccct caccaaccgc 2665981 gatggagtag gctccagctt cagccccggc taaaatatca tagcggcgca gcgggtcttt 2666041 ccctaaaaaa agatcctcaa gcaaaagcgg atcacctccg ccatgccccc cttcattttt 2666101 gaccacttgt atcgtctgct ttgattcaaa aagcggatag tattcgattg tctgctcagg 2666161 aaaagcaaac ggaattctgg aaggttcgtg aaattcattt gattcaatac gtccttttgt 2666221 gccgttgatc gtcagccggt agccttcata cggggccgaa aaaataatcg agtagcttaa 2666281 cagtgcgccg ccatcatatt tgactgccgc cacgtacgta tcctcgatgt caatttcctc 2666341 gtcaaaaata cacgcgtcag gcctgtatgc agtatataag ctggactggt ctcctgcttc 2666401 aagatgatca tcctttatag aagctttaga ggaacgggga tgccaccttg aatagtagtg 2666461 gcatttttct ttaacacggc acgtcccgca aaaacgcccg tcttcttccg gcaaggggtt 2666521 ccactcactg tccggcccat agtaattcaa ggcgccataa gcaaatacct cttccggatt 2666581 ttgcccgagc caccaattga cgagatcgaa gtgatgtgtt gatttatgga cagaaagacc 2666641 gccggaaaac tgtctcgacc tgttccagcg tttaaaatag ctggcgccat gatacgtatc 2666701 aatataccaa tttaaatcaa cagaagtgac cctgcctatt tttccgtcca gaatcatttc 2666761 ttttattttc cgatgaaacg ggctgtagcg atagttaaac gcgacggtga cttttccttc 2666821 gcttttggcc tccgcttcaa gcacccgatt cgcatcctgc actgttgtca ccattggttt 2666881 ttcagtaatc acatctgtat tccactgaag gctttttaca atatatgcga catgcgtatc 2666941 gtccctgcct gccacaatga cgatatcagg ctttgagacg cgcatcatct cgtcaaaagc 2667001 atcttcgcta aactcaggca cgtgggccag ctcgggaaat ttcttcttgc aaacggcaaa 2667061 acgtttcgga tcggcatcca gcaatcccgt aatctcataa tgagttgaaa accgctccat 2667121 cagtggtttg ataaacatac tgaatgctct gctgctcaat ccgcaaaaga cgatgttctt 2667181 caatatcctc acctctatcg ggcttcagtt agttgagaaa tcagctgcag cgcttcctct 2667241 gttttttcag catacacagg gataaacgcc gccatatcgc gattcaattg aaaagaatag 2667301 ccgttcagct gttttttccc tttttcgatc tgaacggcat agatcgtttt ttctcctgtt 2667361 tttttattaa cagttgtata aggagatgtt ttttcaggag gcaatccgtt taacggctga 2667421 aaattttccg gatcatcgta agcttgaaac atgtcttcag gcacgatgaa aacatctccc 2667481 tcatgggcgg taatttcagt cagcagtttt tcctgaaaag ctggaaagat atcgaccttc 2667541 ccggcattct gctcggcggc cttttttatt ttttcctgta cgccagcctg catatcagaa 2667601 aagagaatga catgcattcc gtccggcctg cttgagcatg atgccaaaaa gagcactgag 2667661 acgatcacac acaaagccgt acgtatcctt tttgtcattt ccccgctgac ctaaaaagag 2667721 gctccagctc tgtcatagct aaaataaacg cgccggctcc gtgcagatcg tttgtgcttc 2667781 tttcgcggct gacataatag tcatagaaac cggctgacgt tccgacacat atgtctttga 2667841 cgagaaacgc tccgtcttct gatgtttcgg ttttatgctg aatcaagcct tgatacgctt 2667901 ttagcagtgt tgtttcgtaa gctctgtcta gatagccttt attgattcct tttgcgattg 2667961 cgtacatgta cagacaggat cctgagcttt ccagccagtt atcagacctg tctcccttat 2668021 caacgatctg gtaccataac cccgtctctt tgtcttgata gcgacagatg cttttaatca 2668081 tgtcctgcag cgtgtttttc cacacatgac ggttcggatg cttcttcggc agctcttcaa 2668141 tcatgtcagc aagagacatg acgtaccagc cgatggaacg tgcccaaaat tccggtgaac 2668201 agcctgtctc ttcattggcc caaggcattt ttttcgcttc atcccaggcg tgataaaaaa 2668261 gtccggtttt tgcatccttc gtatgctttc tcatcaatga ctcctgaagc acaacctgat 2668321 caaacagctc cgtctcctgc ttcagattgg catatttcag tgcaaacggc ccccccatgt 2668381 ataagccgtc aagccacatt tggtaaggat aaccgtcttt gtgccaaaaa ccgccctcag 2668441 acgtccggtt cagtgttcca tataagctgc gcagcctttt tgccgctttg acataccgtt 2668501 catccttcgt ctgctcgtat aatggaaaaa gaatgagacc tgcttgaatg gcgtccagtt 2668561 catctcttct aaataataga ttgccattat catcgattaa gagatctgca taagccttcg 2668621 catactcaaa ataccgcttt tccccggttg cttcccacag ccgcaataca ccgcataaga 2668681 aaacaccctg atggtagtgc cagcggtttg caggtggcag ctcctcgact gtgtacgtgt 2668741 tcataatggt gtttgccaat gcctccgcgt acgtaagagg cgattttaca gcgattgatt 2668801 gatccattga tcccatccct ttcctaataa attccttcct cgccaaattt cttcgccaaa 2668861 cgattcgcta gcatgaccaa aatcagcccg accgccgctt taaatacgcc gactgctgta 2668921 ctgtagctga attggccctg tttcagccct gcagtataaa catacgtatc aaaaatttcc 2668981 gccacttccc tgttagtcgc atttaacagc aaatacacat gctcgaagcc aagctccagc 2669041 gtgtctccga ttttcaaaat cagcaaaacg acgataacgc ttttaatggc gggcagcgta 2669101 atatgccaca tttgccgcag ccgtcccgct ccgtccattt tcgccgcttc atacagctgg 2669161 gggtcaaccg ctgtaatggc cgccagataa atgatcgtcg accagcccgc ttccctccag 2669221 ataacctgca gaatatacag gggccggaac cattcttcgt tcagcagaaa attgattttt 2669281 tcaccgccaa aaaacacaat cagttcatta atcaagcctc cgtctaccgt taaaagcaca 2669341 aacgaaagcg atacaacaat gacccaagac ataaaatgcg ggatataaat cagcgtctga 2669401 acaaattttt taaagagagc aatccgcact tcgttcaata gaagcgccag cagtatcggc 2669461 accgggaaaa atatggccag gttcaaagca aataacacga gcgtgttttt taacaagaga 2669521 aaaaatgtag gctcagtaaa cagcctgata aaatgcttca gccccaccca ctcactgccc 2669581 aaaatgccga ggaacggctg ataatcctga aacgcaatca caattcccca catcgggaca 2669641 tacttaaaaa gcaaaaaata aatacacccc ggcaaaatca tcaagtacaa atatttttgt 2669701 tgaatcagct tgattagtaa gcgctttctt ttttcttttt taaaaatgac tgcatcaaca 2669761 gccggcgctt gcgcttctgc tgttttcatt ttttcctagc ctcctttcac ggattcttgc 2669821 attcactgta gcgcagcagg caaaagtccg tctacaatca tatgatcaca tcctgtttta 2669881 tccctttata atcaagggtt cagccggtcc acctgaaaaa aagacaccga tattagaaaa 2669941 tgattattga caatatctat caatctttgg attaattgta ttaaggtgaa gtggatgtta 2670001 tgaaatgggg ggttttatga aaagaagcca atacaagttt tactacaaac tgatcacgtt 2670061 tttctgcctg ctcagcacca ttccggttat tttggtcgga ttattttcgt acgagcactc 2670121 tcagaaaacg gctatttcca acgtttcgga ggaaaaattc gacacactcc agcagaccca 2670181 gcaaagcatc gagcatatat tgaaaaccgt cgatcactct ttaacccact atgtgagttc 2670241 gccgcctctc cttcgcacat tgtccgagcc tttgcactca gaccaatttc aaatctataa 2670301 ccaagtgaac caagagctca attatctgca aagctttgat accgatctgt ccaacatgac 2670361 gttagtcagt tatacgaaaa aatggtacat gaacaattcc ggtttgtacc gtttgaatac 2670421 agacactctt catgaagcag cctcagcgta cacgaaacaa aaagcgagcc gctcctattg 2670481 gacgcttgag gaaaacaatc atttgatttc aaccaaagaa ggcacagcag aaaactgccg 2670541 ctacaatatc aatttaatta agcagcttcc tttgaacagc acaaatacaa agggattggc 2670601 cgccgcaagc atcccgagct gttcgcttgt caaaaatatg cccggctatt caaacgccaa 2670661 caacctgttt atcatcgatg aaaaaggcct catcatcctt cataacaata tgtctgacgt 2670721 tggtgaatct cttcataacg acggctttgt ccaaaaagtg ctggcgcaaa cggccaatag 2670781 cggacagttt gaaacagtga ttgaccggat tcattataaa gtcacctatc aaaaatctga 2670841 ctataatgca tggacttatt tttctctcgt ttccctgcct gagttaaaaa aagaagccaa 2670901 atcaatcggc tggatcactt ttgcagtatg cctcattttg ttaacgcttt cattgctgtt 2670961 ctcttggctt ggctcccgcc atttttacaa gccgatcagg gtgctttacg aatcattcgc 2671021 aagacatgga gccatacaag agaaacaaca gcctcctcaa aatgaatttg agttaattga 2671081 acagagcttt aagcagctga aggacagaaa tgacgacctt gaagaaacga tgaagcagca 2671141 ggccactcat ctgcagcaat attttatggt caggcttatg cttggaaaac tgacggatga 2671201 ggaggttgat aaccgttttg aaagcctcgg cttaaagcaa aattggcggc accttgccct 2671261 gcttgtgctc caaattgaca cactgaatca tacgccttat gagaaaaaag atatggatct 2671321 gcttttgttt gccgtcaaca gcctgattga gcgcaacatc ccgacggaca aacatcttgc 2671381 ccccgccgta gttgacaaac agcaggcgac gattttgatc aatcaaagcg ggacaaagga 2671441 agaattcatg gctgagctga atgagactgc aaggatgatt caggaaaaag cggaagctga 2671501 gctgcagctg tctgtcagca tcggcatcag ccagccgttt gatgtgctga caaaagcgaa 2671561 aacagcctat gcggaaggct cagaagcgtt gaaatatcgg ctgaaagcgg aaaacaagtc 2671621 gatcatcttt tacgaagacc ttgaccagaa aaaaaccttc aaaacccatt ttccaaagca 2671681 gcttcagcat gagctgttcg atgctgtcaa agcaggagac aaggagaaag cggataaatg 2671741 cctgcacgcg attttacaag ccattttcac ccagaacacc aacccgtatc aatttcaaat 2671801 cgccatcgcc cgttttttga accatgtgat tgagctgatg catgtgcttg ggatcgaatt 2671861 gtttgagctt gaagaaaaca aaatgctgta tgaccaaatt tttgagctga aaacgttcga 2671921 ggataccgaa aactggctaa agaatgagtt tattgatccg atgacagaca aagtgaacgc 2671981 ccgcgcggat gcccagtaca aaaatatttc cgacaacatc attcatatca tccatcatga 2672041 gtttgaatcc gaattgacac tggacgaaat cgcacgcagg ctgcattaca acccaaatta 2672101 tttaagcagt attttcaaaa aagaaatggg aatttcattc agcgagtatg tctcaagcta 2672161 ccgacaccat atggcgaaaa gctggcttgc cgaaaccgac atggcggtca aggacattgc 2672221 cgaaaagctg aaatataaaa actcccaaaa cttcatcaga tcatttaaga agctggaagg 2672281 gattacaccg ggaaactacc gccagcaaaa aagaagcatg taaaaaaccc aaaaccgctt 2672341 gcgcgttttg ggtttttcca atgttatttt gcttgtttaa acgcttcttc gtattcctga 2672401 ataatttgtt ttcctccgct tgactcccat ttttccactt ctttatcgaa ctggctttct 2672461 gtgatgtctc caatcatata tttgtaggtc gcgtcatcaa tgattttctt cagttcgtca 2672521 ccccgttccg actccgatgc ggaatacagg ctttcagccg ggtttgagac gataatcttt 2672581 tcattgtcct cggtcagctc ctcgtacgcc gtccgaagcg gatctccagt gttttttaag 2672641 taggctttat caatggcaat taaagcggac agcggctgaa tatcagtctg ccagtctttt 2672701 acctggcttt ctttgcgtgt aaacgttttg tcctcacctt tgttgtaatg aacgccgtca 2672761 atgccataag tcatcaggct atagacatct tcttcggcaa ttcggtcaaa aaacgccaag 2672821 atccgtttaa gctcagcttc cgttttcaca ctcgttttcg ggaaagcaaa cacgccgtta 2672881 tggcctcctg atgcccatac ccgctctttc ccatctgggc cttttatgcg gttgatgatc 2672941 tcgagcttca tcgatttatc agaggcatgg tcgcgcagat tgaccgcatc taccatattg 2673001 ccaatataaa ttccggcttt tccttgagaa aacagctctt gctgctgggt tttgcttgtg 2673061 acgggaaaat ccttattcat atacccgtta tcacgcagct ttttcatata gttcatcgtg 2673121 tctttgtatt cctgtgtcat gaaatcaggc gtgaatttgc cgcccgattc cttccaatct 2673181 gtcggcatgc cttcatacga gccaatcgtt ttaaacgcgc cgtaaatcaa gtcattacgg 2673241 tctgccagcc cgaatgtatc atctttccca tccttgtccg ggtcgtcctc cgtaaatgct 2673301 ttggccactt cataaagctc atccaacgtt ttcggggttt tcaaatttaa attgtccagc 2673361 cagtccttcc gaatgacgat cccctgtctg gaaagcgggc gctctctgta tatcccgtag 2673421 agcttgccgt caattgtcac atttttatta atgagtttgt tcattttgtt taagttggga 2673481 taatccttga tataatcgcc gatttcccaa aacattcctg accgaaaggc attcatgact 2673541 gacgaatttt taatatcctg gatggtcacg atttgcggaa gattgccggc tgcaagcgct 2673601 gcattcagcc tgtcttcttt caccgcgtct ggaacccagg tgatgtcgag ttctgtattt 2673661 gtcagctttt caatttcttt aatcgccctg tctttcggcg gctgctggtg atacaaaatc 2673721 gccatccaag acagctttac ctttgaatct gggccagctt tgccttcagc cgaagactga 2673781 tcagttcctt tacagcccgc cagcactccg ccgagtgcca gtacaagcac aatcaaaagc 2673841 accctccatt tgtttcccat cgtacccctc cgtttcatat ttctttatcc tttgacagat 2673901 cccagcaaag ctccttttgc aaaatgcttt tgtataaacg gatagacaag cagaacaggg 2673961 atggtcgcca ccactatgac cgccatttta atggtttgct caggcggcgg gctgcccgac 2674021 cccatttcag acatatcccc ctgcataccg cttgatacaa tgacgatttg gcgcagaagc 2674081 acctgaattg gccattttgc tgaatcattt aagtacaaga tcgctgtcat atacgtgttc 2674141 caatacgtga ccgcataaaa tagtgaaatc gttgcgatcg caggaagaga cagcggcagc 2674201 acaattttaa agaatatgcc cagatcattg cacccgtcaa ttttcgcgga ctcttccagg 2674261 cttgacggga tattttgaaa gaagtttttc agaatgatca ggttaaaggc attaatggct 2674321 gtcggcaaaa taagcgccca gtaagaatcg agcaatccaa gcgatttgac cacaaggaaa 2674381 gtcggaatca tgccgccgct aaacagcatc gtaaatacga cgagaaacat gagcggctgc 2674441 cggccgatta aatcacggcg ggataacccg taagccatca gtgacgaaag aaacatgctg 2674501 accgcagtgc ctatcactgt cacaaacaca gaaacaagca aactcttata aataatatct 2674561 gttgaaaaaa tgtagcgata agcatctagc gaaaaagtgg tcggtattaa aataaatttt 2674621 ttcgacacga cttcttctac tgtggcaaag gatgctgcga taacatgaat gaacggaagt 2674681 acgcatatta aagcgaacat cagcaagaaa ccataaatca acatatcaaa cagacggttt 2674741 ttcagtgaat gtgcgatagc tcccacctcc ctttgtaagc gttatcatat ttttggaaac 2674801 cgagctcagc atgtgacgat atcgtgtcta aaatgtagca aatctgtgat tgccatgtct 2674861 ataatcattt gaacagtgtc cccggccggg cgggggctgc cgcgaattga gaccgataac 2674921 aaaagaaaaa gagcataatc ttagaaaatg attatgctcc gttctcctcc tcgttcagaa 2674981 gttcagccgt attgatttgt ggcgaaaacc caagttcatt cacggcagat tcaatggacc 2675041 atggccggcc cggattatca gagacggcgt aataagtgcc ataccggatg ttggtctcaa 2675101 tggcggcttt gaaaatcgac agcagatcgg ggtgagaaag cagtgtcttt ttcgtccgtt 2675161 ctttttcatg cagcgtatcc atttcatctg tcacgactgt tccgattcga aggttgatta 2675221 ctgatagctt attttccaaa taaaacaaat ggccgatctg ttcagaggtc agctttaata 2675281 caccgtacaa gttttttgac agcggataat cgcttgttgt gatttcccgt cctaagagcg 2675341 agcgcccgtc tttttcatat acatctgtga catgattgct gctggcgaac acgagctttt 2675401 gaatgccgag ctccgctgcc gcacggcaca gataatagct tgccctatag aaaacatccg 2675461 tcattttttc aaactcagcg atgtccataa tatcgtattt gattttcaca gcgagtaaat 2675521 tcaagatggc atcggtatct tttggaatct tcttcaacag ctcctcataa tttgccgcgt 2675581 cagcctgaat ggaagaggct ttgccatcga aatgatcttt atcaagcaca gtcacttcat 2675641 agtctgaaat aagcccttca gcaagcagtc tcccaatcac accatttccg ccggcgatca 2675701 gcactttttt cacgatgttc actccccttt tttatagatt gcccattttc ggcggggctg 2675761 acactttttt ggcactcaca ttcttaggct tattcaaaag tcaccggcag ctcctcaagc 2675821 gcccgaaatc caaaaagcgg ccgataccgc cattcaaaat ccgcaagatt aaggctgggc 2675881 attcgctgca gaagagtgtt aatcgcaatt tgcgcttcta atcgtgccag cgaggaccct 2675941 aagcaaacat gatggccatg cccgaatgaa agatgcggat taggacttct cgtaatatcg 2676001 aagacatcgg ggttcgtgaa tatgctaggg tctcgattag ccgctcctaa caaaagatag 2676061 acttgttctc cttgacggat cgtcaccccg cagatgtcaa tatcctctga cgcaactctg 2676121 gctgtcattt gcgtggggct ttcatagcgt aaacattcct cgactgcggt accaataaga 2676181 tctggatttt ctctcagttt caaaagctgt tctggatgct gcagcagaca aaggactgaa 2676241 ttgctgatga gattgaccgt tgtctcatgt ccggcgatcg ccagcaatat gcacgtagat 2676301 gccgcctcct cttccgtcag cttatccttt tctctcccct tcaagagcat gctgatcata 2676361 tcctgttgag ggtggcgttt tctcttttga atcagctctt tgaaatatgc catagcctgc 2676421 acagccataa tattgccctc tgttaatgcc tttcttgagc gggtaaaatc aatcgtttga 2676481 atgagactcg cagcccactc ctttaattgc tccctatctt cctccggtac acctataatg 2676541 ttagctatga caaaacttgc taaaggaaaa gcaaagtccg aaatgacctc catctttttt 2676601 ttaccttgca cttgatcaag caaatgatgg acagtttcaa tgatatacgg ctgataactc 2676661 tctgtcgttc tcggcgtaaa cgctccgctg gcaagcgtcc gcaatcgtct atgatcaggc 2676721 tggttctgaa acagcatcat ttgattttgc acatgtgaaa ggtcctgata tttggttgag 2676781 ctctcaggca gcggggtgcg gactttgaat ctcgcatctt tcaaaatagc agccgtttct 2676841 tcatatcctg tgacatacca gcccgggtat tttaagaaac tccctttata gataggatga 2676901 acagctcgca atgtgtcgta aaaagaatat gggtttttca aaaactcaga agatgcagtt 2676961 gacgatgcaa ttgtcacgtg attttctcct ttctgttcaa aaataaaaac aatcgacatc 2677021 ataccgattg cttttattga ttctttcagc ttttcgcact taaactagcc ttcatttctt 2677081 cgactgattc aacttcaaag cctaaatcac tcagcatttt atgatcctcc gtctcctctt 2677141 gcccggcagt tgttaagtag tctccgacaa aaatggagtt tgcggcgtaa agccctaatg 2677201 gctgcaatgt gcggagattg acctctcttc ctccggaaat gcgaatttct tttgatggat 2677261 tgataaaacg gaacagcgcc agcactttta aacaatacag cgggtttaat tcgttgacgc 2677321 cttctaacgg cgtgccatca attgcatgca aaaaattcac aggaatggaa tccgcgtcaa 2677381 gagccttcaa gcttttggcg atgtcaatga catcctgttt cgtctccttc atcccgataa 2677441 tggcgcctga acacggagac agccccgatt cttttgcgat ttcaaccgta ttgactctgt 2677501 catcgtatgt atgtgaggtt gtgatgtttg aatggtttct ctgtgacgta ttcaaattat 2677561 gattatagcg gtctactcct gcatctttga gccgcttcgc ctgctctggc ttcaacagtc 2677621 caagacatgc acaaatcttc agtccatacg tctctttaat ttcctgaacc gcatctacga 2677681 cctgatccac ttctctgtta gacggacctc tgccgcttgc cacgatacaa tatgtgccga 2677741 tattcagatc gtgcgcccgc ttcgcgcctt caagcagcgt ttccttattc accatccggt 2677801 aagactcaat cggcgctttc gaaatcgcag actgtgaaca atagccgcag ttttccgggc 2677861 agagcccgga tttcgcattc ataatcatat tgagctttac tttttttccg taaaagtgtt 2677921 ttctgatgtg aaaagccccg tgcattaata gcaaaatatc ttcatcagga caatgtaata 2677981 ttgaaagcgc ctcttcgtca gtcacttctg ctccagccag cacccggtct gcgagttcca 2678041 tccattgatt cattctcata cccccacttg attcatcagt aatgatagat tgatatggtc 2678101 ttttaccata tgtagaaccg tttctttcgt cacgttggca agctttggcg taacccctaa 2678161 aatcggcaca ccgcataagc gctcaatcat ctcaggattg gttttttcat cttcatcagg 2678221 agagtcactg attccattga tgataattcc ggcgattgga agccccatgc tttctgcata 2678281 tttgacagtt aaaaaggtat gattaatggt tccaaggcga ggacgcgcca caataatcat 2678341 gggaagctgc aacgctttta tgacatgact gaccaaatag tcctctccca atggcacaga 2678401 aataccgcct gcaccttcta cgatgaagca ttcatgtttt tctctaatcc gcccccaatg 2678461 gcttaaaacc tcttccatgg tgacagtctt tccctcaagt ttccctgcaa cgtatggtgc 2678521 aagcggcgcc ttgaaggcaa aaggcgtaat gtcttcatga gaaagactgg tctgcgacat 2678581 atctttcagc aaacttgtat cactatctgg atgatggcgc gatatcccgc ttaaaaatgg 2678641 tttatacacc ccgacatgtc tattattgtc tttcaataag gcagcaagac cgctggatat 2678701 aaccgttttc cctacttctg tatcagttcc cgtcacaaaa aaacccctca aatgatgtgc 2678761 agctcctttc cgattgaatg aaatgtttgc agcaaatgat caatatcacc catactgtgg 2678821 tcagacgtga ttgtaattcg aatccggctt tcacccggcg caacggttgg cggccgaatg 2678881 gcaggagcat aaattccctt gccctgcagt ttttcagcaa ataggaccgt tttatgggca 2678941 tcgccaatga ctacaggaat aatcggtgtg tgatctcctt tcaccacata acccatattc 2679001 ttcagactgg ttctgatcat gctgatataa gaaaataaaa gctgtcgttt ttccctgctg 2679061 gcttcaatga tgttgaaagc ctcgtgagca gccgcacagc tggctggcgg aatagcggtt 2679121 tgaaagataa atgttctggc atggttcagc aaaaagtcga tgaagaccgc tgatcctgcc 2679181 gcaaaacctc cttccgcgcc aacagctttg cttaaggtgc cgataacaat gtcgggacaa 2679241 acaccaaagt attcactcgt tccttgtccc gaatcgccca aaactcctgt tgcgtgggca 2679301 tcatcaacga ccacgaaggc atgatagcgt ttcgcaagtg agatgatctg atcaagaggg 2679361 gcgattgtgc catccatgct gaatactccg tctgttacga taaaacggcg ctgataacgc 2679421 tgtgtttcat tcagcttgtt ttcaagatca ttcatatcaa tatgccgata aacaactgta 2679481 tcagccttag aaagtcggca gccgtcgatc atacttgcat gattgagctg gtcacttaaa 2679541 atgacatctt ccttttctgg caaggatgaa aggacaccga cattggccaa gtaaccgctc 2679601 gaaaacagca gggccgcttc tgtcagttta aagctggcaa tcttcttttc tagcttttca 2679661 tgccagaccg aattgcctgt cgttaaacgt gaaccgctgc ttcctgtccc aaattgctgc 2679721 aatgctgttt gggctgcatc gatcaaacgt ctatcgcttg cgagccctaa ataattgttt 2679781 gaggaccaga ccgtttgatt ttcgccatca atattcctct ctggaaccgg cgctccatcc 2679841 attgaccgca ggttacgatg tacgccggct tctttcattc tgtctaaccg ctcgtttaac 2679901 caggaatcaa tcttcaaggc tcgtaacctc gtggatcgct tgtttcataa tggcaaccat 2679961 ttccgagagc tcttcagctg tgctggcaag aggaggaaga aatgcaatca cgtccccaag 2680021 cggtcttgtc agcattccta actctctcat ttttaaggaa actttgtatc caatccgccg 2680081 atcagccggg taaggttctt tagtttcctt tgatcgtaca agctctgcac cgcacataaa 2680141 gccaagctgc cgaatatccc caacatgagg aagagcgtgc agatcttgaa gaagaaaatg 2680201 gagcttttta cttttttccg ctacttgttc cacaatgttt tcagattcaa ataatgccag 2680261 attttcaagc gcaaccgcac agccaagctg attgcctgta taggaatggc catggaaaaa 2680321 ggtttttagg ttttcataat catcatagaa tgccttatag atgtcttcag tggcaaacgt 2680381 aacggcaatt ggcaaatagc ctcctgtaat gcctttaccg gcagccatca gatcaggctg 2680441 gacattctcg tgctcgcacg caaacatttt tcctgtacgg ccaaagcctg tagcgacttc 2680501 atcaacgatc attaagacat cgtatgttgt acatagctcg cgcacgcctg ccaaatatcc 2680561 ttccggcatc acgatcatac cggacgcgcc ttgtaccatt gattcaatgg aaagcgcggc 2680621 aatttcctca tgatgttcct caagcagctg tgcaagctct cggaggcact gatcacggca 2680681 ctcatcagga tcaccgcttt cagaacgata cacataagga atcggggcct tgtaactctc 2680741 gaacatcaac gggccgtata cgtggtgaaa aagctcaatt gaaccgacac tgacggcgcc 2680801 aatcgtatca ccgtgatacc cgtttttcat tgcgatgaat ttttgtttct cgggcttccc 2680861 gatgttcttc caatactgaa acgccatttt tagggctatt tccatcgcct ctgcgccgct 2680921 gtctgaataa aagacccgcg tgagcttttt tgggctgatg tcgattaatg tttcggcaag 2680981 ctgggttgct ggaacattgg tcatgcccaa taacgtggag tgcgcaattt ttccgagctg 2681041 tttttttatg gcgtcatcta gttctttttt gcggtgtccg tggacattaa gccaaaccga 2681101 tgaaaaaccg tcatagtatt ccttgccgtt tatgtctttg actttgattc cagtcccgct 2681161 ttcgatgatt aaggggtttt catcataatc tttcatttgg gtaaatggca gccagaggtg 2681221 ctttttactt ttttctatca aatcatgagt catgatcttc ctcccactct attaaaatag 2681281 gctgcttctc caggtcatgt atgtacgtgt ttacatcatt ggatccatca ataaaaaaga 2681341 ctcggcagcc ctcttcagtc ccgtattctt tcattgctgt aatacgctga tagcccattt 2681401 tcttacccgc aacatagcct gttatgtaat ccggatcgtc cgaccagcat aattctgcaa 2681461 cgactgccgg gtgccggctt acctttgaag cgagcgcaag ggcctctttt attcttgaat 2681521 gagctggcac gtgactgtga agcgcccatt tttcaaaatt agcgtccggc caatccattc 2681581 tggagacccg cacccctttt tcttttgttt gatccattcg cttgcctgta tgaatatcaa 2681641 acaacaccgc acccctgaca tctgaccatt cagggatttg ttcatatgct ttttcaatca 2681701 cgtctcgtga aacgccttct ttttccaata acaatcgggc aagcttttgt ccttcttccg 2681761 ggcagctcac ttcattcgta tgcacaggca atggctgaat ggtttttatc gattcatgta 2681821 cctcttcaaa ttgaatttgc ataaaatcag gttttcctct tgaatgggat aacccttttt 2681881 ctaataaagc attgactgta tgcttcatct catggaaagg aataagccgt tctccgccgg 2681941 atatatgctt tccgccgtct tcatgagatc cattcattga agccctcatt ctgacactat 2682001 aaaaagtttc ttcttgcatc atttctcgcc ctttcactga taactgaaga acgtgtagcg 2682061 cttctcacct aaattgttaa ccaattatat tcaaaggtta acaattagaa tatattattc 2682121 tctcctgttt ctgtcaatag aagaaaggat cgatttatgg cagttggtta aaaggaaaca 2682181 aaaagaccgt tttcacacaa aacggtcttt ttcgatttct ttttacagtc acagccactt 2682241 ttgcaaaaac cggacagctt catgccttat aactgctgtt tcgaaatgtc ccgaagcaga 2682301 acggaccact cggtagcaat cagcagctcc ctgtccagca tagacagctg tcaattcttt 2682361 ttcgattttg tccacgccct cagccggcgt taaccgatcg tgtacaccaa caagactaag 2682421 gtgcgggcgc ggcgcgatca ggctttggat ctccgatgcg gaaaaatgct ttgcaagcga 2682481 tgggacgtaa taataaaagc cgtgcctgtc aagattctgt gttttgatca gcacgtgatg 2682541 atccacctgg ctgcacaaat ccacacacac cttaatccgg tcatcgagcg ccgctgtcca 2682601 ccacgccatc aaacctccca tagacatgcc gatggttccg atcctgtcag gctgaacatc 2682661 agagcgtgac tgcatatagt ctaacgcact taaactgtca taaatcatca tcccccacat 2682721 cacttttccg gtgagaagca tttctttaaa tatctcgctt tccgcttttc cccgccgatc 2682781 tccaaacccc caatgatcaa tcgcaagaac gccgtatccg agtgaagtaa gctcatcaga 2682841 aaaagaaggc gttttcaaat aatccgctcc ctcaatcagc tcactttttc ccctatcata 2682901 ctggcctcca tgcgaatgct gaaacaatac ggctgggcac ggtccttctg ttttcttcgg 2682961 cttcacaaaa taagcgggcg ccttttcatg tccatttaaa tcgagcagga gcgtttcaac 2683021 gatattttct tctctttctt caatacgtaa tgtctcaaca ctgattggcc tccgatcagg 2683081 caaatcacca agcaatcgaa acagttgctt tcttctttcg gctctcatcc catcaccctt 2683141 ccttattcgc ttacttcaca tttacgagac agatctgggt tcccctttat ttttccaaca 2683201 taaatcacat catttactaa atatttagta aatattatgg aatatttcga aaacaattat 2683261 tgtaaccgct tacttttata tgataatatc aatttatcaa aaacagatga gttaatattt 2683321 tactaaatag atgagaggga tacccatggt tcgtattaaa gatatcgcct tgaaagctaa 2683381 agtttccagc gcaactgtgt ccagaatttt aaatgaagat gagtcgcttt ctgttgcggg 2683441 cgaaacgaga caaagagtca tcaacatcgc tgaagagctt ggttatcaaa ccgttgccaa 2683501 acgccgaaaa tcccgcgggc aaaaacagcg ggctcagccg ctgatcggtg tgctgagctg 2683561 tctgtcccct gatcaggaaa ggcaggaccc ttatttttct tccattcgga aagggattga 2683621 aaaggaatgc tttgaacagg aaattttcat tacaaattcg attcatctcg gctcctttca 2683681 ggaacatatc tttcgggaat tggatggtgt cattgtcatc ggccgtgttc atgatgaagc 2683741 ggttaagcat atcagcggga ggctggagca tgccgtattt atcaatcatt caccagatcc 2683801 gcaagcatac gattcgattg gcatcgattt tgaatcggct tcacgccagg cgattgatca 2683861 ccttttcgac ttaggctaca aacggttagg ctacattggc ggacaagaaa aagagcatac 2683921 gctgaaggac ggccaaagca ttcgcagaac gattgaagat aaacgcctga ccgctttttt 2683981 ggagtcagcc gccccccagc ctgagcatgt gctgatcgga gaatacagca tgcgtgaggg 2684041 ctatcgcctg atgaagaaag caatcgatca aggccatctg ccggaagcat tctttattgc 2684101 cagcgattct atggcgatcg gcgcattaaa agcgctgcag gaagccggac tgcaagtgcc 2684161 gcgggatacc gcaatcgtca gctttaacgg cattgaggaa gctgaatttg ccagcacgcc 2684221 tttaacgacg gtgaaggtat acacagagga aatgggccgg acaggcgtaa aactgctgct 2684281 tgaccgtctc aatggccgaa cgcttcctca acatgtcacc ctgcctacaa cattaatcgt 2684341 aagacaaagc tgcggatgta cagcaaagga ggtgacataa gcaaagattc atcacgatga 2684401 taaggaggaa aagatgaaac acacttttgt tttatttctc tctcttattc tgcttgttct 2684461 gcccgggtgt tcagcagaga aaagctcagc agataccgca aaaaagacgt taaccattta 2684521 ttctacaatg tcaaccgaca gtgaaagaga tacgttcaga aaactagcgg cagcattcga 2684581 aaaggaacac agtgacattc atgtcagcct tcatttccca ggcaatgact atgaaaatat 2684641 gatgcgtgtc agaatggcgg ccaatgattt gccagatcta ttcgatacac atggctgggg 2684701 gaaaatcagg tacggagaat atacagcgga tctccgggat atgaaatgga ctcaagatct 2684761 tgatcccaat ttaaacagca tcctcaaaaa taaaagcgga aaggtgtatg cctatccaat 2684821 caatcaggca aaagacggtc tggcgtataa tcgcaatatt ttagaccgtt acggcattgc 2684881 tccgccggaa accatggatg actttatcaa agcactgaga acgattaaag aaaagagcaa 2684941 gggaagcatt gttcccttct ggtttgccgg atatgacaaa agctcattcg cccaatatta 2685001 cgaccaattc gctacacctc ttctcatcac agaccctgcc cataatgaaa aaaaacagct 2685061 catcaacggc acttttcaat ggagtaaatt cacttattta tcagaaatcc tcaaacaaat 2685121 gcagaaagaa aaattgatca atatcgacgc cgtcacggca aaaaaatcac agctcattga 2685181 attaatggcc caaaacaaaa tcgcctttac aatgcaaggc ggcacactcg gccaagacgt 2685241 tgcccagatc aacccgaacg tcaaggtcgg cattatcccg acacctgcca tccatcccgg 2685301 tgatgacccg atatggatcg gcggtgaacg ctacaccctt gcagcatgga aagattcgcc 2685361 tcaattaaaa gaggcaaaag attttatcgc atttatggcc cgcccggcca atgccaaaca 2685421 aatggctgaa gccacatcgc ttccttcagg gctgaccaat gtgaaagctg atattttcta 2685481 cgcaaacgat tatgagtatt atcaagatgt caaagtcgag ccttacttcg accggttata 2685541 cttgccaaac ggaatgtggg atgtcctggg cacggttggg caggagctcg cggctgacat 2685601 tttggcgcct caagacattt cgcagaagct gggaagagaa tataaacgac tccgggagca 2685661 atccgaaaca cagggagctg aaaacaatga gtgagatcgc aagggacgtt catgtgaaac 2685721 aggttaagcc aaaaaagcag tcctcacttt ggtggatgta cattcctgct ttgctctccg 2685781 ttctggtctt tatgatttac ccgtttgtga aaggcacatt gattaccttt acaaactgga 2685841 acggattttc acaagtctac caatgggttg gattcgcgca atatgaaagg ctgttttctg 2685901 atcctgatac ttggcatatc ttaaaaaaca cgctgcatta cgggcttggc agcacctttt 2685961 ttcaaaatgt ggtcgggctt ctgtacgctc tcctcttaaa tcaaagcatt aaaacgaaag 2686021 cggtaacaag aacaattgtg tatttgccgg tgatgatcag cccgctcatt atgggctaca 2686081 tttggtactt tttcttctcc tatgacggag gcgcgctcaa cgatttgctc ggggtcttcg 2686141 gcatcagccc tattaatgcg ctcgccagtc cctcgctcaa tccatggatc attgtcatga 2686201 ttaacaccta tcaatatgtc gggatcgcta tggttgtcta cttagccggt ctgcaaagca 2686261 ttccgaaaga ctactatgaa gcggcgcaaa tggatggcgc gaaacaaggc cagcagtttt 2686321 ttaccatcac gctgccgctg ttaatgccct ccattaccat taatatagtc atcaacatta 2686381 tcggaggctt aaagctgttt gacgtcatca ttgcactcac cgcaggcggc cccggaaatg 2686441 cgtcacaatc catgtccacg tttatgtatg atttgtattt caaacggcag gatgccggct 2686501 atgccgcaac gcaaggcata tttatggcat ttgtcatttt gatcatcagc ttttgcgcgc 2686561 ttgcgtactt taaaagaaag gagacggaaa tgtcatgaga gccgcccgta caaaaagcat 2686621 gcggatcatt acgcttcttg cagccattgt ggcctgtgcg cattttattc ctttttatat 2686681 cctgctgacc acttcattga aagcaaaagg agactacagt tcgaaatgga tatttccagc 2686741 cgacatctcc tttcataatt tttcagaggc gtgggagcgc gcttcgctag gaaactcttt 2686801 tataaacacc atgatcatca caggtttttc tgccttgtta ttaattatat tcggctcact 2686861 tgccgcctac ccgcttgccc ggcgggaaac gaaactgaat aaagccgttt ttgccttgct 2686921 gatttccatt atgatcatcc ctccgttaac gtccatggtt cctttgtacc gaatggtcgt 2686981 ggacgccgga atggtcaata cacacgcaat cgccattttc atcaatacag cggcttacat 2687041 gccgttaacc gtattcttat attcaggctt tatccgatcg accattccaa aagagcttgt 2687101 agaagccgca agaattgacg gtgcaggcat gctgaaaatc ttttttacga ttgtgtttcc 2687161 tctgctgaag ccgatcactg cgaccatctg tatcatttct tgtgtcttta tttggaacga 2687221 ctatcaattt gccattttct ttttacaaga tcaaaaggtt cagacattaa cagtagccat 2687281 ggcaggtttt ttcggagaaa acgcaaacaa ccttcattta gttgccgcag cggcacttat 2687341 ggcaatgctg ccgatggttg ttctgttttt ggcgctgcaa aaatacttta ttgccggcct 2687401 gtcttccgga gcggtaaagg gttaacatta aagggggaag caatatgaaa aagattacat 2687461 ttatcggtgc agggagcacg attttcgcca aaaatgtttt gggagactgc ctgttaacag 2687521 aggcactgaa tggatttgag ttcgctcttt acgacattga tcccaaacgc ctgcaggaat 2687581 cccagctcat gctcgaaaat ctaagagacc gttataaccc aagtgtggcc atcaacagct 2687641 atgatgacag aaaactcgcc ttgcaaaacg caggctatgt catcaatgcg attcaggttg 2687701 gaggatacaa accgagcaca gtcatcgatt tcgagattcc taaacggtat gggctgcgcc 2687761 agacgatcgc cgatacagta ggcatcggcg ggatattcag atctctcaga acaatcccgg 2687821 tcttatttga tatcgcaaaa gatatggagg aaatgtgccc tgacgcatgg ttcttaaact 2687881 atacaaatcc aatggccact cttacaggcg ccatgctccg ctataccaat atcaaaacaa 2687941 tcgggctctg ccacagtgtt caagtgtgca cgaaggattt atttaaagct ctcggaatgg 2688001 agcatgacgg aattgaggaa cgcattgcgg gcattaatca tatggcttgg cttttggaag 2688061 tcaaaaaaga cggcacagat ttatatccag aaatcaaaag gagagcgaaa gaaaaacaaa 2688121 aaacaaagca tcatgatatg gtgcggtttg aattaatgga taagttcggc tattatgtca 2688181 cggaatcgtc cgaacataac gcagagtatc acccgtactt tattaaacgg aattaccctg 2688241 aactgatcag cgagctgcaa atcccgctcg acgaatatcc gagaaggtgc gtcaagcaga 2688301 ttgaaaattg ggagaaaatg cgggatgata tcgtcaataa taaaaacctt acgcacgaac 2688361 gctcaaagga atatggttca agaattatag aagcaatgga aacaaacgaa ccattcacct 2688421 tcggaggaaa cgtcttgaat acagggctga tcaccaacct tccttcaaaa gcggttgtgg 2688481 aagtgacatg cgtcgccgac agaaaaaaaa ttacaccgtg cttcgccgga gaactgcctg 2688541 agcagcttgc agccttaaac cggacgaata ttaatacaca gctgatgaca atcgaagcgg 2688601 ctgtcacacg aaaaaaagaa gcggtttacc aagctgcaat gcttgatccg catacaagcg 2688661 cggagctttc catgaaggac atcatctcca tgtgcgacga tttatttgca gcacacggcg 2688721 attggcttcc ggaatacaaa taaaaactag gggaccgctc tcccctagtt ttttggtttt 2688781 gtttcgcctt cccaggccat catgccgcct tcaacattga ctgttttaaa gccttgctca 2688841 tccaggtact tgcagacgtt catgctgcgc attcctgagc ggcagataaa tacgtactct 2688901 ttgtctttat caagggtttc cattttttca ggaatatccc ccatgcgaat atgaacggct 2688961 tgcgggatca tgccttccgc tacctcttca tcttctctga catcaattaa atataattct 2689021 tcgtccgcct caattttttc tttcaaagcg gctgtgctga tttcttttat ttccaaagaa 2689081 aacactccta ttcacagtga tcatgttcag tatatcaaag tcagccgaac gattgctatt 2689141 ctgagactga tgaaaaaaaa tccccttttg gcaaagggga ttttttctag gcttagtttg 2689201 ccacaatatt gacaagcttc ccaggcaccg cgatgatttt ccgaatcgtt ttgccttcaa 2689261 gctgctcttt gaccttttca tctgcttgag caagctgttc cagctgttct ttcgttgcat 2689321 cggcaggaac ctgtaatttc gcttttactt ttccgttcag ctgaacaacg atttcaactt 2689381 catcatccac aagttttgtt tcatcatata caggccaagc ttcgtaggca attgtgccgg 2689441 aatggccaag cttctcccat agctcttccg ctaagtgtgg cgcgacagga gaaagaagct 2689501 tcacgaagcc ttccatatat tctttcggca gttctgttgc tttataagct tcattaataa 2689561 agaccatcag ctgggaaata cccgtgttga aacgaaggcc ttcataatgg tctgtgactt 2689621 tcatgaccgt ttcatgatag acgcgctcca atgtttcacc cgcgccttca acgatttttc 2689681 cattaagctc accgctgtct tcaataaata ggcgccatac acggtcaagg aaacggcgcg 2689741 caccgtctaa tcctgattca gaccaggcga ttgaagcatc aagaggtccc atgaacattt 2689801 cgtacaatct cagcgtatca gcaccgtgag aggccacgat ttcgtcagga ttgacaacgt 2689861 tccctttaga tttactcatt ttttcgttgt tttcgccgag aatcattcct tggttgtaca 2689921 gcttttggaa cggttctttc gtcggcacta cgccgatatc ataaaggaac ttatgccaga 2689981 agcgggcata cagaaggtga agcacggcat gttctgcacc gccgatatac atatcgaccg 2690041 gaagccattt ttccaatttt tctggtgatg ccagctgatc cggattgtgc ggatcaatat 2690101 agcgcaagaa ataccagcag cttcccgccc attgcggcat tgtattcgtt tctcttcttc 2690161 cttttttccc tgtctcaggg tctgtgactt ccacccactc tttaatgttc gcaagcggtg 2690221 attcgcccgt tccgctcggt ttgatttcat ccgtttttgg caaaatcagc ggcagctcct 2690281 cttccgggac agctgttgac gttccgtctt cccaatgaat gaccggaatc ggctcgcccc 2690341 aataacgctg gcggctgaag agccagtcac gaagacggta cgtcactttc ttctcaccgt 2690401 ttttcgtttc ttccagccaa gcgatcactt tttcaatcgc ttcctgtttg tgaaggccgt 2690461 tcaggaaatc agagttcacg tgctcgccgt cgccagtata ggctgcttcc tcaacgttcc 2690521 cgccttttac gacttccttc accggaaggc cgaatgtttt ggcgaattca aaatcacgct 2690581 catcgtgtcc tggaactgcc atgacagcac ctgttccgta tgatgcaaga acataatccg 2690641 caatccaaat cggcagtttt tctccgttta caggattgat cgcatacgct cctgtaaata 2690701 cgcctgtctt tgttttcgca agatctgtgc gttctaggtc actctttgat tgaatttctt 2690761 tgatataagc ttcaacagct tctttttgct ctgccgttgt gatgttttcc accaatgcgt 2690821 gttccggggc aaggacagtg tatgtagcgc caaacagcgt atctggtctt gttgtaaaca 2690881 ctgtaaagga atcatcatgt ccatctatag caaaatgaac gtgagcgcct tccgaacggc 2690941 cgatccagtt gcgctgcata tctttaatgc tttccggcca atcaagctct tccaagtcct 2691001 caaggagcct gtccgcataa gcggtgattt tcagcatcca ctgcttcatt gggcgtctct 2691061 ctaccggatg gccgccgcgt tcgctcttgc cgtcaatgac ttcttcgttg gcaagaacag 2691121 taccgagcgc agggcaccag tttacaggca cttcgtcaac gtaagcaagg cctttttcgt 2691181 atagctttaa gaaaatccat tgcgtccatt tatagtattc agggtcagtc gtattgattt 2691241 cgcgatccca gtcatatgag aagccaagcg cttgaatttg gcggcggaag ttatcaatat 2691301 tctgcttcgt aaacacagcg gggtcgttcc ctgtgtcaag cgcgtactgt tcagctggca 2691361 ggccgaatgc gtcccagccc attggatgaa ggacatcata gccctgcatg cgcttcatgc 2691421 gggacagaat atccgtagct gtgtatcctt caggatggcc gacgtgcaac ccagctccag 2691481 acggataagg aaacatgtcc agcgcgtaaa atttttgttt ttcattatta tcaagagtgg 2691541 caaatgtttt gttttcaagc caatatgtct gccatttctt ttctatctct ttgtgctgaa 2691601 aactcaaagt aaaaacctcc ttctgattga atacggcgtg tatggttcaa gtattgacgg 2691661 gaaggagagg attatattca gaatattccc aaactaaaaa aaactccctc atcccaaaaa 2691721 gggacgagag actttcgttt tcccgcggta ccaccctcgt tagcgcggca tacgccgcac 2691781 tcacttgata cttttaacgc agttatgcgt cagcggcttt tcaccgctgc aactctgagg 2691841 tgagttcgga aacaaacttg attgactttc accagccgtc aactctctgc aacaatatct 2691901 gtttcttact gctcctcttc attgttctta tcgcaaccgt aatctaactg tattttatag 2691961 aattctgttc ataagtgcaa gcaggtttgt atacaatggg aatgtaccct gaacgggcgg 2692021 agattgagga caattattcg ggtggagttt tggtttgacg tttggactcg gccggttcgc 2692081 cgccgctgtt cagttctctc acaaagtcaa aacttctgag aacagcttca ccgccgtagc 2692141 ctgagataat ggataagatg acaagttgaa ttcctgaatc ggggtcagcg gataatacaa 2692201 gtaaaatgga agccgtcatg ccgataaacc aatcttccaa aaatccaagg tagataaacc 2692261 gcttcgtcat tctgggcttc tccagcctgc ctctcttttt cacatgaccg agaatcccca 2692321 tgattcctcc aattacacaa gcaatgagta cctgatgcag catcttcatc atcaccttcc 2692381 taaagccctt atttcgtaaa gcgacttcag gccatccagc ccccttaaac gattccgatg 2692441 attttcgata tctacatacc ggcaaatctg taaaaagctt gtttcttcca ttatatgtga 2692501 acacatgatc ggtaagcttg atgcattgga ttcatttttc acccagtgac attgacctag 2692561 tcacctattt agcatgtaga aaacctttcc gttcatatgt tcaaattctg ttcttatttt 2692621 tagtgtatac gaggacaagc cctaatgaca aacaacaaac tgcacttgct tgaatcagaa 2692681 catgtgttgt gctacggtta ctgtagaatt catttttaaa aaggggaata tcaggctttc 2692741 gcatagcaag ctgacggcct aagggggatt tatatggcta gttttcaatc atttgggata 2692801 ccaggacagc tggaagtcat caaaaaagca cttgatcacg tgcgagtcgg tgtggtaatt 2692861 acagatcccg cacttgaaga taatcctatt gtctacgtaa atcaaggctt tgttcaaatg 2692921 accggctacg agaccgagga aattttagga aagaactgtc gcttcttaca ggggaaacac 2692981 acagatcctg cagaagtgga caacatcaga accgctttac aaaataaaga accggtcacc 2693041 gttcagatcc aaaactacaa aaaagacgga acgatgttct ggaatgaatt aaatattgat 2693101 ccaatggaaa tagaggataa aacgtatttt gtcggaattc agaatgatat caccaagcaa 2693161 aaagaatatg aaaagcttct cgaggattcc ctcacggaaa ttactgcact ttcaactcct 2693221 attgtcccga ttcgcaatgg catttcggct cttccgctag tcggaaacct gacagaggag 2693281 cgatttaatt ccatcgtttg cacattgacg aatatcttat caacatccaa agatgattat 2693341 ttgatcattg atttatccgg attggcccaa gtgaacgaac aaacggccga ccaaattttc 2693401 aagctgagcc atttgctgaa attgaccgga actgagttaa tcattactgg cattaagcct 2693461 gaattggcta tgaaaatgaa taaactggat gccaattttt cgtcgctgaa aacatattca 2693521 aatgtaaagg atgccgttaa agtgcttccg attatgtaaa aagatcccgc tcacccagct 2693581 ggatctttca gattgttgac aaaatcctaa aatggttttc attttaggat tttgtcatct 2693641 tttcagcgtg attgaaaacc cttgaagtct aggaaggacg agcataggag cggagcgaat 2693701 gttctaattc gtgagcaccg aagcgcaggc ctgacaacga atgcgagggt ttgtcgacac 2693761 gctgaaagat cccgctcatt cggcgggatc ttttattatg aagagattga tgcctgctta 2693821 tttgtttctt tagctgattt tatccgtttg tcatatagaa gcgttgtggc aatactgatc 2693881 agcagcaata ccaacagaga taaaacaaga gccctaatgc cgtaatgatc gacaagcact 2693941 cctccgaaca ggggaccaat cattctgccg cctgtcgccg cactgttgac aaagccttga 2694001 taaaagcctt ctttcccttt aggggcaagc tgattggcaa tagtcggcac agcaggccaa 2694061 acaagcattt ctccgatagt caggatcacc atcgcagcga gaaacatcgg aaattgcttt 2694121 gcagtcagca gcatgctgaa agacacaata aaaatgataa agccgatgac catttgcgct 2694181 tttagcgact cggcccattt tttcaccaca aaactgacga gcggctggcc gagcacaatg 2694241 agaattccgt taaccgtcca cagcacgctg tataaggaaa gagatattcc aatgctttgt 2694301 gtgtacgaag caattgtggt tgaccactga gaataagcca gccatccgag tacatagcct 2694361 ccgcttaaaa tgatcagtgc ggcaaatttt gctttgctgt tcacagcatc ataatcaagc 2694421 acggatgttt gggatgcatc gcccgtttga atatttcgaa atccgaaata tacaataaag 2694481 aaaaagatca gatacaatac ggcatttgcc aaaaatacat atgaaaacga gaaagatgcc 2694541 acgacaccgc caagcgctga accaacggcc acgcccgcgt tttgcgcgac atatatcgca 2694601 ttaaatgcct tccttccccc ttcaggccat accgatcccg ccattgcgta gcttgccgga 2694661 aaaacaacac cggagccaaa gcccacaatc gtcagcagca caatataggc tggccaatca 2694721 tgaaaaaaga caagacccat caggcttgct aacgtaatgg ctatcccaag cataatcgat 2694781 ttaaaaccgc cgattttatc aaacaaaaaa cctccgcata aattgccagc cacactggcg 2694841 ccggaattca gcatcaggac aagtccggct actgttaacg actttcctaa atgattatgg 2694901 atataaatcg tattcagcgg ccataaaaaa gaagcacccg tcacattgat aaacattcca 2694961 atgactaaaa ttttaagagc acgcggcata ctcatccccc tttcttacct aaaaaagctc 2695021 atgaaaaaaa cgaaacctaa aacggctccg tacgaatcca gttatcatag cacattcatt 2695081 ctatctgtct ctctcacatt tttcaactga tgagcgtgaa aaaatctaac aaatattgtt 2695141 tgaaaaatgt aaaataaata gaaaaagggg tcatattatg gaaatggtat tagcattctt 2695201 aggttttctg gcatgtctca ttgcactggg ctatggatta tatcaccttg tcagatatgt 2695261 actgaaaaag gaaaaacgtt tctcaaagag acttttttgg ccgcttttca ttggaggcct 2695321 tgtgctgctc tttaccgggg cagcattggc agaacctgac actgccgcag caaatgccga 2695381 gaaaaaatat tcagcgctaa acgccgaata taaaaacctc acaaaagagc acgaagaact 2695441 tgagaaagaa tataaatctg tcagctctga agcaaagaaa ttaaaagaca acaaagaaga 2695501 tcaagacaag cttgagaagc ttaaaaacga aaatagcgat ctaaaaaaga ctcagaaatc 2695561 attaaaagct gagattaaag agcttcaaga aaatcaaaag cagctcaaag aagatgcaaa 2695621 aacggcaaag gctgaaaatg aaacacttcg acaagataaa acaaagcttg aaaatcaatt 2695681 aaaagagacg gaaagccaaa ccgccagctc tcatgaagac actggaagtt cttcaaacaa 2695741 tacgagtaaa agtgatgaaa ccaaaacagc tgacaaagca gaaggctgta atatcaaagg 2695801 aagcagaaac ggcatctacc acacgccagg cagtacatac tacgaccgga caaccgatcc 2695861 ggctgaaatg ttttgctcag ttgaagaagc tgaagccgcc ggttatcggg cgccaaaacg 2695921 ataaacaaaa agctccagaa tgtctggagc tttttctgtt tcacaacgac gatttaatga 2695981 ccttcttata ataaagaact gacagaaaac caaaaatgga gtagagcgca gtatataaca 2696041 ccatcaccat aatcataggc gcccatacct ctgatccgaa taagaaccag ccggattgga 2696101 cggcaaagta actgtggaag aggccgacaa cgagcggaat gccgaagttg tacatttgtt 2696161 tgatgcgtat cccctttatc aggtcgccct gcgtaaagcc gagttttctt aaaattgtat 2696221 agctcggttt ttcatcttca ctttcaccca tttgtttaaa ataaaggata caacctgatg 2696281 taatcaggaa cgttaaccct aagaagccga cgatgaacat caccatacca aacagtgatt 2696341 tttgcgcagc gcttgtatct agtcttgata aatgctcgtt tttcttgttc acctgttgaa 2696401 aaagctcatt tgctttttcc atttgatcgt catgtttcac attgacgccg ataaatgtag 2696461 attgcgccag ctgaatgcgg gggtctttat ccttgtccag ctgtttaaac aggctgtcat 2696521 ccacaatgac agcgggcatg cccccgcttg taaacgtgta ggacacaaga aactcttctc 2696581 ttaatccttt atattttaat ggctgcgtct cgtgcttgct ttttacttta ataacaccag 2696641 agtccttgaa aaccattatt ttttgcagca agtcggtgta tcctgagaaa acggcttctc 2696701 cagccgccac atcgactcct tttacatctt tgtcgctaac aacagcaagc tgcatattgc 2696761 cgggatcgcc ctgcatctct ttcggagttc catccataat atttgcaatg tcaacatttg 2696821 cttgcaggac aggtgttgcc ttttttacaa acgagatgtt gctttccctc aatttgtttt 2696881 caaataactt ggcatctttc tcattcatga atgaaaaatc agccgctaca ttttgttcag 2696941 cggtcttttc cgacgagtaa tacgagatgt aagcaagaga taacagcccg atggcgagcg 2697001 ctgaaacggt tgtaataatc gtcagcagca gcgcattcga tttcattctg aacatgatcg 2697061 aagacagtga cagaacctca gaaatattta agtagccgcc cttgcttttt cgaatgatat 2697121 tcgagataaa cgtaactgat cctttataaa acaaaaacgt cccgataatg acgctcccca 2697181 gaatgaagct catcgcaaca aacagttcat taatggtctt aaattttccg ccaaacagct 2697241 cagaagacac atagtatcct gtcaaaatca acacgatgcc taaagcgccg atcagcattt 2697301 ggaaaaatga tattttcttc actttgtctt cagtggagga cgttacttta aacaaagata 2697361 aaatactctg ttttttgata aacgtataat tcatgatcat gatcaaaagg taaatgccgc 2697421 agaacacaat gaccgtttgg accaaggcct gctcagaaaa atgcagtttc gcatccgctt 2697481 tgacatcgac aattttgaac agaatcatca agacaagctt cgatatcgaa aacccggccg 2697541 ctaccccgat cgctaatgaa ccgaaataca gcatgacatt ttctgcactt aagatgcgaa 2697601 aaattttatg cttcgtcatt ccaattaatt gaaacagccc gatttcttta ctccgtctct 2697661 taataaaaat cgtattggca tataaaatga agatcgccac tacagccaca agcaaaatcg 2697721 aagcggtttt aatagccgcg gctcccttga ttgaagcctt cacttcgtta attgctggat 2697781 catactgcag cgtgacaaag gcgaaataaa gcgccacgct aaagatgagc gcaaacacat 2697841 acaaatagta attccggaga ttctttttca aatttcgcag gatgagctga ttaatgttca 2697901 tgctgcaccc cgcctaacac gccttgcgtt ttcataatat cctggaaaaa cgtttgcctg 2697961 tcctggcccc ctttattcag ctgtgtatac atttgcccgt ccttaataaa aatgactctg 2698021 ccgcagtagc tggcagcgac gggatcatgg gtaaccataa taatcgtcgc gttgcgtttt 2698081 tgattgagct ggctcagctt atttaataga tcggaggccg atttcgaatc gagcgcgccg 2698141 gtcggttcat cagcgaaaat aatgctcggg tcatgaataa acgctcttcc agcggatgtt 2698201 ctctgcttct ggccgccgga aatttcattc gggtatttat cccgcaattc atatattccc 2698261 agttccttgg caacttcctc aaacttgcga ttggcttcct tttttgatag tttcgtgatc 2698321 gataaaggca gaaggatatt ctctttcact gtcaatgtgt ctaacaaatt gtaatcctga 2698381 aagataaagc ctaaatgctg ttttctaaat tcagccagct gcttttcctt catagccgtc 2698441 atgtcatttc cattaatatg aatggttccg tgactgacct gatcgattga ggacagaacg 2698501 ttgagcaaag tggtttttcc cgacccggaa gcacccataa tactgacgaa ttcgcccttt 2698561 tcaatgtgaa tatcgatgcc cttcagcact tcctgtttat tcagcttgtt tccataactt 2698621 tttcgaattt tattcgcttc taaaatcacc atttacgcag tctcctttat attggataat 2698681 ctcattataa aaaggaatgc cgggcttttc cttcgatacg gcgaacaaaa aagaaaagca 2698741 tgtgacattt tcgtcacacg cttatgacat gttcaaattg attccgtatt ggaaaggtta 2698801 atgtaaaaac tgttcccgca ccaaactccg actcaacatc aatatggatc aataacggcg 2698861 ccgctgcttt ttttgccaag tacagcccca tgccagttga cgcttgatca tggtgatccg 2698921 ttgtggatgt aaacccttta tcaaaaatac gcggtacatc ttttggatca atgcccctgc 2698981 cacaatcttt cacttggagc tgcgtctgtt cccctttttg aaagcttttg atctcgattt 2699041 cagaggcttc gctgtatttc accgcgtttg tcagcagctg cctgatgata aacgccagcc 2699101 attttgcatc gctcagcact tctttggcct cgagctgtat gtcaaaaccg atcccttttt 2699161 ggatacacca cgattgtaaa tctttgattt ctttaaagat caaaggctga agctgaatga 2699221 attctactga caggtcgttt tcaataaatg aaatgcgttt ttgatgaagc tgctgatcaa 2699281 gaagcaggtg aatacgcagc cattcatatg acagctggga tttcagtgct ttttcttcca 2699341 ttctatcaat gattaaatgc atcgctgtta atggagtttt gacctcatgg atccatgcca 2699401 tcagctcatc tttttcattt tccaatgcta agcgatgccg tgctgcggtc tgcttcaagt 2699461 gttctgtttg cccggcaatg cttctttcaa ccattgcttc aaacggcgtt tccggttcat 2699521 ttatggctgt cacatcgaga ttgttctccc atgttttcaa gcttttataa aacgctgttt 2699581 ctttccgata gcggaaccaa aggaatatga taaaaaacaa gatgcacaaa tacaccatat 2699641 aaagtacatt cccaaatgat atggaaggat cgacaaaagc aatgaacagc atcaaagcct 2699701 gctgaaacaa aaacgcggca atccagctcc gcctttcgat aaggaatgct ttaatcatag 2699761 aacttgtcct cttccttcgc gatgtagccc tggcccacct ttgtctcgat atatgcacca 2699821 agctgcaggg cgtccagttt ttttcgcagg cgattgacat tgacggtcag cgtattatca 2699881 ctaacaaaac gctcatcgtt ccacaagctt ctgatcagct cttcccggct gacgatcttg 2699941 tttttttgct ctattaattg ttttagaatg aacatttcat ttttggtcag ttcaacagat 2700001 cctttgtcat tgctgacgag gttctgctcc gcgtctacag cagcgccgca ccacgtttta 2700061 atcgtactcg gctccgtatt ataatggtgc acacgccgga acatcgcttg gattttcgcg 2700121 atcagcacat caaaatgaaa tggcttttga ataaagtcat ctgccccgag ctgcatggac 2700181 atcaccatat cagcaggatg atcccgggag gataaaaaga gaatcggaac atttgaccgg 2700241 gagcggatca gacggcacca atgaaagccg tcaaatttag gcagctgcac atcaataatg 2700301 acacaatcag gattaaccgc cgcaaattcc tgcagcacct gactgaaatc ctgaatgccg 2700361 tatacatcat aggaccatcc cgttaaacga tccttgattt catgaaacag cgattcatca 2700421 tcttcaatca gcaaaagttt aaacaatcga ctcaccgcac tttttccttt tttatcaagt 2700481 gtatagcaaa acgccagcat gcgctataga aaaagccggc tgtctcagcc ggctcgttcg 2700541 cattataatt ctcttctcaa cgctgtcagc acgttggttt tggtagcttt tctcgccggg 2700601 ttcattccgg aaatgactgc gacccctccg caaatcacaa cggcaatgat cacaaggctc 2700661 gccgggatgt aggagaatgt gtaattcaaa tcgcccgcat cgccaccgct tgtggccgca 2700721 agaatcatcg gaacggccag gttgacaagg tagctcacgc cgtaagaaat gataatccca 2700781 atcacacagc ctaaaattcc gatatacgcg ctttccatca agaacattcg gcgaatgatt 2700841 gacgggctcg ccccaatcgc tttcataatg ccgatctctt gcgttctctc tgtcaccgcc 2700901 atcgtcatcg tgttaaaaat gccgatcgct gaaatgataa ctgcgataca tccgacaaag 2700961 atcagtccga ttttgaagac catgaagaag gtattggctc cctcaagttc agtagtcact 2701021 gatgtgacat agtacccgtc atctgttaga tcatttgtca gctgttccac attctcaaac 2701081 ttatcagcaa aaacaccaat gttcgtttca acatttccgc ctttgaaatc taagaattcc 2701141 gaaaaatctt ttttgaattg atcactgata aaaatatttg agtcctccat ccagtcttga 2701201 gatggttttt ttgtaatacc gacaatttta aagtcatatg tttttgtttt tgtaacatcc 2701261 cctgttttag aatctgtctt cgatacactt agttcaattg ttttatttag aatatctttc 2701321 gtatagccct ttggttcttt tatatcttct ggatttcctt ttgcttcctc gatttttttg 2701381 ttatattctt ccgattcttt tttcgttaat aatctctttg cgaagtcgta tcctactacg 2701441 atttcatttt ccgactttgc gactcttccc ttttccaatt ccatattggc ctttaattca 2701501 tcattcatat tagtaaaaat gagatttgag ctttcatttg tacgattgcc taaagtagct 2701561 ttgtttggtt catacacttg cgttctttct acaactgacc ttacgtgatc atacttctct 2701621 aaatcagctt ttttaatcgg cttgtctcct tccttgccca ttacgctgac tttcgttaca 2701681 atctgctggc tcattgtcat atctgtaatc gtcttttgaa tcccaaatcc aacggacgac 2701741 aacacaacca aaaacgcaca cgccattgtt gtcgccagaa tcgtcataaa gacgcgaagc 2701801 ctgtttttct tcatatttct tctgataaaa tgaacctgat ccttaaacct caacggtaat 2701861 tcctcctttt agcacaccat catgaagctg aaattttgaa tgtccgatag aagcgacttc 2701921 atcatcgtga gtaatgatca caaatgtaat gccacgctca cgattcagct gctggatcaa 2701981 ttccagcact tcatgttccg tttctgaatc aaggcttccc gtcggctcat ccgctaagat 2702041 aatcgaagga tttaaaatca atgctcgagc aatactgaca cgctgctgct ggccgcctga 2702101 cagttcattc ggataatgag cggcgtggtt ttccagaccg acgcgtttca gcatgtcctg 2702161 caccttttgc ttccgctcag atggcttgat tccttttaac gccagcggca tttccacatt 2702221 ctcatacgtc gttaaacccg ggatgagctg aaagctctga aaaataaacc cgaaatggtc 2702281 aagccgaaat tgcgcccatt ccttttcatt aaaccccgta acatcagtgc cattaatgac 2702341 aatccgccct tttgtcggcg atatgtagcc ggaaattaaa ttcaaaagcg ttgatttccc 2702401 tgagccgctt cgtccgacaa tgcaggcgat ttcccctttc gccacgctca atgaaacatc 2702461 cttcaatact ggaacttcat tctcacggcc cttttttccg atcgtgaaag aatggtcgat 2702521 atgctgaaca tcaatcatat gttctctctc ccttacaaaa gtttcatttt tttataaatc 2702581 gcaaaataac taatcaagaa accgattacc gcacctgtac ccatgccaat gagataaccg 2702641 gcaaagctct cgcttgcagt aaatccaaaa tagccgaagc ccatgattcc tatgataata 2702701 acgatgatct gcaccgggcg gttaagcggc ttccataaga agaaatatcc gtttctttca 2702761 ttagacattt taacaaagct aatatagccg atgatgtaaa aaatgatagt catgatagcc 2702821 ggaatgacta aataatatgg tgaattctca gcccatttcg agtctacata aattatcgga 2702881 atgaaatact gcacccattt aggtactgga ccatggataa aatctattga tccgccaaaa 2702941 aggatctcga ggttgatcac aggcaggctg atgagtaaaa acggcgaaat ggccacggta 2703001 aatgagacta gaagctgtgc gaaactattg cctgtcaaag ctcctccggc cataaccaaa 2703061 gaataagcca gcatgctaac aataatcatt cccaagctgt aattgtgaaa ataaacggcc 2703121 tgatctggct tcaaaagcat gatcagcaaa acagacaaaa cataacctat gagctgcggc 2703181 accacaatca ccattccgcc ggtaaggaac ttcgcatgaa atatctgccc tcgtgtatat 2703241 ggaaggctta atgtaaaatc aaagaagctc ttgctacgtt caatcccaag ctggctgacc 2703301 gccaaaacga ctccccaaat ccaaaacaat gagataaatg agctatttaa ataatcaacg 2703361 ctgaatacgc aggggccgac ccaattttct tttccagtga cacagccttg atagatgaga 2703421 tacatattta aaattgataa tggattacct aatataaaaa ccaaaatggt gataactaag 2703481 gcgactttat tctgccgcca ctctttgtaa agcagtccgg aatccggcaa ctcacttccc 2703541 tccaaaccta aggcatttct tacacttttg ttttcttata aatagagaag tagctcacaa 2703601 agaatccagc cactgctcca atgatcatac ccaaaatata accaataatg gaatgtccgg 2703661 tatagtatcc aaataaacca aatccaagga tgccgaaagc cataaccaga atttgcaccg 2703721 ggcgatctaa tctgttccat aagaaaaagt gtccgttccg ttcacttgga agcttcttga 2703781 agcttataaa gccaatcaag taaaatagca tgctcattac ggctggaatc aataaaagat 2703841 atttactgtt aatcagccat tcatttacaa cgtaactaat cggtactagg ttcgataaat 2703901 tgcttgccag agagaaataa ctctcagggg aagggaatat ttcccatata ttcgcaccaa 2703961 aaacaacttc taggtttcca accggcaatg caataattaa atacggcaat atagctgctg 2704021 aaaacgccgt taacagttgg gcaaaagcat ttccagttaa cgctccggcg gccatcacca 2704081 gtgaaaaagc cataaaactt atcacgatta ctccaatgct gctgtgctca aaaaagtaga 2704141 cgtgttcagg gttatagaca agaatcagca gccatgcaag taaaaagcca atcaattgtg 2704201 acagcacaat cacaaaaccg cctaaccaaa attttgtctg aaaaatttgg cttctgttat 2704261 acgggaggct taatataaaa tccatcgtgc ctttcgaacg ctccattccg aggaagcaga 2704321 ccgccaaaat gacacccggc acccagttga tatctatcag attgcttatg gaataattca 2704381 caataaaatc acaatattgc gggtcttggc gatcaagaca cccttgataa gacaaatacg 2704441 tattaacgat agaaagcgga tttgccaata ctaaaaacgc gatacttaac aaaatcacca 2704501 cttgattctg cttccactct cgatagagga gacctcggtc taccatctcc gcttccctcc 2704561 aaacttcgca atgaacactt cttccaggtt gacaggaagc tcattccaca cttttggctt 2704621 cagctctctc aaaaagctct ttttctcctc atcgcttttc ggaatcagca ctgtgtaaaa 2704681 cacgccggcc tgatcgagca tcggaatgtt ttgctctctg atggccaaat tgacatctgt 2704741 atcgaaggcc atttgaattt taatgtattc ttcttttaac tcatcaagat ccatgacgtt 2704801 ggtcaggctg ttatcttcaa gaaaaccaat tcggttgcac atccgctcta tgtcttcaag 2704861 ccggtgggac gtaatcagga tgctcgtatc acgctctgcc acttcatcga ccatcagctg 2704921 cagcacatca tgccttgtca ccgcatcaat accatccgtc ggctcatcaa ggaggatcag 2704981 cgccggtctc gccgcaaacg acagaacgag cgatagctgc ttttttaagc ctgtcgacag 2705041 ctcacggtat tttttcgttt ccggaatttc gtatctgttc atcagctcat tcgcgtacgt 2705101 gacatcaaat ttcggatata ttcttctcaa aatatcgact aactgcttgt atgtatactt 2705161 atcgtaaaac ggattttgaa caggcatgta gatgatattt tgtttgactt tcgggtgctt 2705221 tttgatttct acgccgtcaa ataaaatcgt tccgctgtca gcgaaaatga tttgctggat 2705281 taagcgaagc atcgtcgttt tgcccgatcc attgcgtcca agcaatccaa agatttctcc 2705341 tttttcgatt gttaatgaaa catcttttaa tacttgattg ccgtcaatcg cttttgacag 2705401 ctgccgcagt tcaatcattt tttttgcctc ccttcacatc agcgctgatt tcctttatcc 2705461 attcgtgcag tttttccagc tcaacccctg catagtgtgc atcgatgatg agctgtttga 2705521 gttgctcttt aatcatcgtc atcttccctt caaccagtgt cgtttttgca ttctccgata 2705581 tataggtccc tctgccccgc agcgtttcaa taatcccctc tcgctcaagt tctttatacg 2705641 ctttgctgac agtgttcgga ttcgcaataa tgatcgttgc caattctctg acagaaggaa 2705701 gcttatcacc aggcttcatg atccctttca aacaaagctc tttcatttgc tgaataattt 2705761 gttcgtaaat gggtgttgag cttcttggat cgatttgaat catttacttc cctactttct 2705821 atacgatctg aaccttttat agataaaaat gatcaattat acttttttgc cattcaaaac 2705881 cgatcatcac aagaacaaga aaaaaagaac aagcgatcac agatgccgca atcagcattg 2705941 gcacgttacg tttgtttcgt tttttatgtt tcataactgc ctcccttaat gtcaatatat 2706001 aaatgatttt atattagtgt ctatagtgta ttacttcaat tagtacactt aatacaataa 2706061 atactttgac tcacaaagtc aatccttttt ttacaaaaaa acggaccctt ttaaaagggt 2706121 ccgttttcct acacatcaag agggtgctgc aggatcatat tattttgcaa agattgaagc 2706181 tgaagtctca ttctgtacag ctgttctctc tgctgatcat ttgacgacag ccatagttta 2706241 ttcaaggcat ttaccgcatc ttctagctgc atttgtgcat cactatattc ttgatcgtta 2706301 taatgctctt gtttagaagc gattttcagc tgttcttcag cataatcata ggcctgcata 2706361 cattgctgga gatgttcatc tactgattgt cttgttgcca cagtaacccc tcctcttggt 2706421 aatggaaatc atccatcatt catattgtag cctcatctga ctttattcaa taaagtaatt 2706481 tatggtcgat attcatttgt tctcttgtga aatgcgtgct acaattttag gatgcaatcg 2706541 tacgcaagga ggcacatgaa ttgtgatgca gaacaatcct tttccttatt caaatacgga 2706601 aaaacgctat catacattga attatcatct cagagaacat ttcggccata aggtgtttaa 2706661 agtagcgctt gacggcggtt ttgactgtcc aaatcgggat ggcaccgtag cccacggagg 2706721 ctgtacgttt tgcagcgcag caggctccgg agattttgct ggaaaccgga ccgatgattt 2706781 aattacgcaa ttccatgaca tcaaaaaccg catgcacgaa aaatggaagg acggcaagta 2706841 catcgcttat tttcaggctt tcacaaacac tcacgccccg gttgaggtgc ttcgtgagaa 2706901 attcgaatcc gtcctcgcct tagatgatgt ggtcggcatt tcgatcgcca cacgcccgga 2706961 ctgtctgcct gatgatgtcg ttgattactt ggcagagctg aatgaacgta cgtatttgtg 2707021 ggtggagctt gggcttcaaa cagttcatga acggactgca cttttgatca accgcgcaca 2707081 tgattttaac tgctatgtgg aaggcgtcaa taaattaaga aaacacggca tacgtgtctg 2707141 ctcgcatatt atcaacgggc tgcctttgga agaccgggac atgatgatgg aaacggcaaa 2707201 ggccgtcgca gatttggatg tccagggcat taaaatccat ctgcttcacc tactgaaagg 2707261 cacgccgatg gtcaaacaat atgaaaaggg caagctggaa tttctttctc aagatgatta 2707321 tgtgcagctc gtctgcgatc agcttgagat cattccgcct gaaatgatcg tccaccgcat 2707381 tacaggtgac ggaccgattg agttgatgat cgggccaatg tggagcgtca acaaatggga 2707441 agtgcttggc gccattaata aagagctaga aaatcgaggc agctatcaag gaaagttctt 2707501 tcaacggctt gaggaggaat cagcgctatg attttgaaga aaattcttcc ttacagcaaa 2707561 gaactgctga aaatggccgc gggagaggga gatattgtcg tagatgcgac aatgggcaac 2707621 ggacatgata cacagttttt agcggagctt gtcggtgaaa acggccatgt atacgcattc 2707681 gacatccaag aatcagccgt ggccaataca aaggaacggc tcggtgacat gtatcaagcg 2707741 cgaacaacgt tatttcacaa aagccatgat aaaatcgctg aatccctccc gcctgaaaca 2707801 catggcaaag tggcggccgc ggtatttaac ctcggctatt tgccgggcgg ggacaaatca 2707861 attacgacaa acggcagttc tacgatcaaa gccattgaac agcttctcag catcatgaaa 2707921 gacgaaggtc tgattgttct cgtcgtctat catggccacc cggaaggcaa agctgaaaaa 2707981 aacgacgtgc tcgagttttg ccgggacttg gaccagcaaa cagcccgtgt attaacatac 2708041 gggtttatca atcagcaaaa tgacccgcca tttattgtcg ccatcgaaaa aaaagctcag 2708101 atcagcaaat gatttgagct tttttctttg aatttttcat ccaggacatt ttttgaaatt 2708161 tccggtaggc tctgccgttg atataaaaga aaagggaggt ttttccgctg gctttgatca 2708221 gcttctttgc gagccggccc atttcctttt ggcctgccac tttatcatct gacaaataaa 2708281 cgccaagcaa gccgcgattg attaaacgat ggaagttttc atgcggaatg ccttgtaaat 2708341 gctcgtcggc tttatggata aagtgttcaa gccggtccat catctcttca tgagactgat 2708401 aatacgagca gaaattcaag tctccttcca gcaagtcctc ctcttgatca atcaaataat 2708461 caagaagaat atgaagaccc tgtatgtaag gaaaataact gtctcggatt tttttagcgg 2708521 tgctttctgt gaaatcaggc tggaacgaat acgcaaccag acagaaaatg cctaacgttg 2708581 agcctgcaca ggctgaaaat tcataccatt ccatctcagg cagctctgat tcatattgag 2708641 taaaccactt ttcaagccgc ggaacacgct catgctcaat aacgtgctta tgcacctgca 2708701 aatcgcaata atagccgcac agttcaagca gataaggttt aatcatgtca tagtgctcaa 2708761 tggagccgag aacacgctgg cacgttttaa ccagttcatg caaatatccg ctgtcatcct 2708821 gttcttccct gaattgataa tagttttgca gttccgcccc aactgtcagt gcgtcctgca 2708881 ttgaggcatg gagcatccga aaatcctgcg ggtccagcga ggtgctgcgg tcacacagat 2708941 tgtccaaata atcactaatc gtttgatacg cgatgataaa ctcgacacat ttctgctttt 2709001 ggctgcctga caataaggcc agtatgccgc cgccttcaca gtgaaacgtt ttgtcccgaa 2709061 tacttgcggt tgcctgtgct ttcaattcac tgttatgaat cgattctgat ttttgcttcc 2709121 atatgtccag ctcttgatga acgagcggaa aaatatctcg atataccttt gccatcaatc 2709181 caaaaggatg ttccggtact gtcaacacat gcacccccta ctagttcaaa tatattgatc 2709241 agtaaacgct cttgctgctt taaaaacatc ttctctctcg ggttcattga agatctcatg 2709301 gtaaagccct tcccactctc tgtatgcttt attatgagaa gcaacaccat taaaccactt 2709361 gatgaccatc gttttgtcaa caagcttgtc atcaccggct tgcatcacaa gaagcggaac 2709421 tttcaaaaat gcctctgtcg gcaccattgc cgattcaatt gtctttaaaa gctctctgta 2709481 ccatctgaca gaaactttcc tgacgtataa cgaatcattt tggtcagctt cgatgacgtc 2709541 ctcattgcgc gtcgccatat caattgataa tcccgaatca accttaagtg acggagcgat 2709601 gacattcagg ccttttgatg caagatcaag cgctttattc actttaattt gcagtccgag 2709661 acacggtgat gataaaataa ttcccgtaat ccggggattt ctttgctgtt taacccattc 2709721 aatcgcgacc agaccgccca tgctgtgacc tagaagaaaa accggaagat caaaggttcg 2709781 cgctttatct atccaagcat ctacttcatc aatgtattct tgaaacgagc gaatatgccc 2709841 tctcgctctt gtcgttgttc cctgtccagg caaatcgccc atgacaacgt gataacccga 2709901 agaccgccac atttcaatca gccatttata tcgtccgtga tattcacttg ccccgtgaat 2709961 gattacaatc acggcaacag gtctgtctgc tttccaggtc cacatgatct tcacctcata 2710021 cgaaatttaa atagagaaag aaggatgaat cttatgatct acccttataa ggaacacaag 2710081 ccagatatcc acccaacagc ctttatagct gataatgcaa caattaccgg tgatgtcgtg 2710141 atcggagaac agtccagcat ttggttttct gttgtcataa ggggagatgt tgcgccgacc 2710201 agaatcggaa acagagtcaa tatccaagat ttaagctgcc tccatcaaag cccgaacaag 2710261 acgctactca ttgaagatga cgccacgata ggccatcagg ttacacttca tagcgctgtt 2710321 atccgcaaga acgccttaat cgggatgggc tcaatcattt tagacggagc cgaaattggc 2710381 gaaggcgctt ttattggtgc cggcagtctt gtcccgcccg gaaaaatcat tccgcctggc 2710441 catctcgcct ttggccgccc tgcaaaagtc atccgccctt tgacggaaga agaccgaaaa 2710501 gatatgcaaa gaatacggtc agaatatgta gaaaagggcc aatattataa atttcttcaa 2710561 caaacataag acctgcttcg tcttacttta ccatttttca aattatattt gaaagcaata 2710621 accatcgtta acccggacgt catacagttc gggtttcgat ttttccataa aacgttcaca 2710681 tatagcatga aacgtatgac ttttatctta tcacaaaact ataaacagcc tctgcaaaaa 2710741 cacataccta ttctttcctg ttctctattt tctatgagca cacacaaaaa gagcccactg 2710801 ggagctcttt ttgtcagctg atatttcgtt cgctggcagc agccgcattt tttttatgaa 2710861 acccttttcc atagtacaca gccagcaaga tgagaaacca tatcggcccg ataatcacgg 2710921 ctactcttgt atcagggctg taagccataa gaatgacgac gaatgctaga aatgccaatg 2710981 acacataaga cgtaaacgga aataaaggca ttttgtactt taattgtttc ttttcttccg 2711041 gcttcaaact tttcctgtat tttatttgag aaagcaaaat gattgcccac gtccaaatcg 2711101 ctccgaacgt cgcaatactt gtaacccaag taaatacctt cgcagggaca acatagttta 2711161 acagcactcc gactaataaa gcgcccgctg aagccagaac agctttaccc gggatgccgc 2711221 ctttcgtcag ctgaccatat gcttgtggcg cctctttctg ttccgccaag ttaaacagca 2711281 tccgccctgt gctgaaaata ccactgttgc atgaagacag cgcggctgtc aacacgacaa 2711341 agttaatgat acctgcggcc gatggaatgc ccactttttg aaatgtgaga acaaatggac 2711401 ttccttgaga gccaatttcc tgccacggat aaatagacat aatgacaaat aaagcgccta 2711461 cataaaaaat caaaatccgc caaaatactg tatcgattgc tttggctaac gatttttgcg 2711521 ggttttttac ttcgccagcc gtcaccccga tcatttcaat ccctaaatag gcgaacatga 2711581 ccatttgaag agacaataaa acccctttta atccatgagg gaaaaatcct ccgttgttcc 2711641 acaaattgct gattccggtt gcaatgcccc cattgccgac tcctgcaata atcatcaata 2711701 aaccgacagc aatcatggat aagattgcaa caattttaat caatgcgaac caaaattcca 2711761 gctcgccgta agctttgaca gccaggaaat taacacccgt cataatgacc agtgccgata 2711821 acgcccaaat ccagtttggc acgtccggaa accagaaccc catatagatg ccgacagcag 2711881 tgatttcggc catacaggtg acaacccata aaaaccagta gttccaacct gttaaatagc 2711941 ctgcaagcgg tcccaaataa tcacgcgcat acctgctgaa ggagcctgcg accggttttt 2712001 gaatggccat ttccccaagc gctctcataa taaaaaacat gaccaggccg cttgcggcat 2712061 acgctaccaa aataccaggc cctgctaatt gaatagctga tgcggagccg aggaacaacc 2712121 ctactcctat agcagctcct aaagacatta aagaaatatg cctttcttcg agtccgcggt 2712181 gcagctcttg tttttgtttt tgcatgcttc ttctccccta gaaaaaaata tcattatatc 2712241 atttttctga atattccgta cggattgggt aaatcaatga tgatggagaa ataaaaggat 2712301 aacaacaagg ctttcgacta ctcgaaagcc ttgttgtctg ttacacaaag atgacttctt 2712361 taggctgatg gctcagctct tcaggcatat accgtttttc aatattgatg ctgtgccaga 2712421 tcataaagat tagcacagtc caaattttac ggctgttatc agccttgtcc gcacaatggt 2712481 cttcaagaag ctgaaggaca taatccttat ggatataagc atccgtttgg ctttcttgaa 2712541 taatattccg cacccattcg ttcatttcgt ttttcagcca atgacggatc ggtacaggga 2712601 aaccaagctt tttgcggttt aatacgtgct caggcacaat tccttcagcg gctttgcgaa 2712661 gaagatactt cgtcgtgccg ttcttcgttt tcagctcatc aggaattttt gaagcgacgt 2712721 cgaatacgac tttatccaag aacggcacac gcagttccaa agaattcgcc atcgtcattt 2712781 tatccgcctt taacaaaatg tcgccgcgca tccaagtgtg gatatcgaca tactgcattt 2712841 tgttgatatc gctgtacgag ctgctttctg taaagtaagt cttcgtcaca tcgcgatatg 2712901 aaaggttcgg attataatgc ttcaacagct gctttttgac agactcttca aagattttcg 2712961 cgttaccgat ataacgatcc tgaagcggag tgcagccgcg ctcaagcagg ctcttccctc 2713021 tcataccttc aggcataacg gcagcaacgt gcagaagcat ctttttcaag ccggacggaa 2713081 tccgttcaaa cggtttaagc gaaagcggtt cacggtaaat gttatatccg ccgaagagct 2713141 catccgctcc ttcacctgat aaagcaaccg taacatgttt ttttgcttct tttgcaacaa 2713201 agtacaacgg aatcgctgcc ggatcagcaa gcgggtcatc aaaatgccat acgatcttcg 2713261 gaagctcatt catgtattcc tcaggcgaaa tgactttgct gatattttca atgcccagcg 2713321 ccgctgccgt ttctttcgct acatcaacct cactgaagcc ctgctgttca aagccgacag 2713381 agaatgtttt taagcttgga tgaaattcct tcgcaacaga cacaataaag gaagaatcaa 2713441 tcccgccaga caggaacgaa ccgacaggaa cgtcacttct catatgaacg tttacagagt 2713501 catagatcgc gtctcggact tctttcacaa gcttgtcttc ttcagtctga accggcttga 2713561 agttcgcttt gaaatacgtt ttgaatgtga tatcgccgtc cgggcggatt gtgaattgtg 2713621 aacccggctc tacttttttc acatgggcat caagcgtgct tggttcagga acaaattgga 2713681 aagacatgta ctgctgcaat gcctctttat ctatttcaat atcattctga gcaaccatta 2713741 aactttttct ctctgaggca aaataaacct gatcattgat cgttgtgtag tacaacggtt 2713801 taatgccgaa tggatctctt gccccataaa gcacatgatc gtttttattc caaatcagaa 2713861 aggcaaacat accgcgcagt ttggacgccg cttcttcttt atagtgacgg taagtcgcaa 2713921 gaagaacctc tgtgtccgaa tccgtgttga atgtgtaccc ctttgcttca agttcttctc 2713981 tcagttcgat atagttatag atttctccgt taaagataat ccaatatgtt tcatcttcat 2714041 atgataaagg ctgtccacca ttttctacat caataatgct gagccgtctg aatccgaagc 2714101 cgacgtgctc atcatggaaa tatccatcac tgtcaggacc gcggtgaacg atcatttggt 2714161 tcatttgttt gattagttct tcttgatcag cggtttgagc taacggatgc ttgttaaaaa 2714221 ccccgacaaa tccacacata gtattgcctc cataattaaa attgtcatca ttgaacccct 2714281 atttatagac gctgtgaata gtatttggtt tcacagttat gtaaaaaaat aaacatgaat 2714341 acaacgataa aaaagggaaa gccgcttaac cagtaagcgg ctataaaatt attctcctaa 2714401 cgcttcttta cgcagctgct ccgctttgtc tgtgcgctcc catggaaggt caacatcgtg 2714461 acgtccaaag tggccgtacg cagcagtttg tttatagatc ggacggcgca aatcaagcat 2714521 tttgataatg ccggcaggtc gtaaatcaaa gttattgcga acaacttcaa tcagtttttc 2714581 ctcagaagct tttcctgaac cgaatgtgtt gattgagatt gacacaggct gtgcaacacc 2714641 gatcgcgtaa gcaagctgta cttcgcaaga atcagcaagc tcagccgcaa cgatgttttt 2714701 cgcaacgtat cttgccgcat aagctgcaga acggtctacc ttcgtcgcgt ccttacctga 2714761 gaacgcgcct ccgccgtggc gtgcatagcc gccgtacgta tcaacgatga ttttgcgtcc 2714821 tgtaagtccc gcatcccctt gagggcctcc gattacgaaa cgtcctgtag ggttgatgaa 2714881 atattttgtt tcttcatcaa tcagctcttc aggaacaacc ggattgatta catgttcttt 2714941 aatgttgcgc tgaatttgct caagtgtaat ttcagggtga tgctgagttg aaataacaat 2715001 cgcgtcaatg cggactggtt tgttattttc atcgtactca accgttacct gtgttttgcc 2715061 gtcagggcga aggtacggaa gaatatcttc tttacggact tcacttaggc ggcgggctaa 2715121 tttatgggca agtgaaattg gaagaggcat aagctctttc gtttcgttgc acgcataacc 2715181 gaacattaat ccttggtcac ccgcaccaat cgcttcaatt tcttcgtcgc tcattgtgcc 2715241 ttcacgggct tcaagcgctt ggtctacgcc catcgcgata tcagcagact gctcatcaat 2715301 tgatgttaaa accgcacaag tttccgcatc aaatccgtat tttgcacgtg tgtatccgat 2715361 ttctttaatg gtttggcgaa ccgttttcgg aatgtcaaca tacgtagaag ttgtgatctc 2715421 tccgcttaca agaaccaaac ctgttgtcac agatgtttca caagcaacac gcgcgttagg 2715481 gtctttcttt aaaatttcat ctaaaatgct gtcagaaatc tggtcacaga ttttatccgg 2715541 atgcccctcc gtaacagatt ctgatgtaaa taaacgacga tttttactca tgatttgctt 2715601 cctcctgcac aaggcctccc gaaagacctt gtatatatga tacggaactc gctccctctt 2715661 atacaatgta cagttatatt agagaatgtt aattggcata tttatgaaat aaaaaaacct 2715721 tttccatcga ggaaagggtt tggtctttgt gcctttcact cttatcgctc aaggaatcat 2715781 acaaccttgc aacaggttag caccttggtt gtctcactca gttgaacata ataaataaca 2715841 gagaaaccgg ttgctgggct tcatagggcc tgtccctccg ccagctcggg ataagagtat 2715901 ccgctcaatg aaatatctta tcgtaaaagg gtttgcaatg tcaatatgat tcagaagaaa 2715961 taggcaccta tattgaggga aaacaatgga aatgcacaca caaaaaacaa taaatagtat 2716021 agactatttg aaaatatatg ttatactaat tcacaattag caaaacacaa aaaacgataa 2716081 aggaaggttt catatgaact cagttgattt gaccgctgat ttacaagcct tattaacatg 2716141 tccaaatgtg cgtcataatt tatcagcagc acagctaaca gaaaaagtcc tctcccgaaa 2716201 cgaaggcatt ttaacatcca caggtgctgt tcgcgcgaca acaggcgctt acacaggacg 2716261 ctcacctaaa gataaattca tcgtggagga agaaagcacg aaaaataaga tcgattgggg 2716321 cccggtgaat cagccgattt cagaagaagc gtttgagcgg ctgtacacga aagttgtcag 2716381 ctatttaaag gagcgagatg aactgtttgt tttcgaagga tttgccggag cagacgagaa 2716441 atacaggctg ccgatcactg tcgtaaatga gttcgcatgg cacaatttat ttgcgcggca 2716501 gctgtttatc cgtccggaag gaaatgataa gaaaacagtt gagcagccgt tcaccattct 2716561 ttctgctccg catttcaaag cggatccaaa aacagacggc actcattccg aaacgtttat 2716621 tattgtctct ttcgaaaagc ggacaatttt aatcggcgga actgagtatg ccggtgaaat 2716681 gaagaagtcc attttctcca ttatgaattt cctgctgcct gaaagagata ttttatctat 2716741 gcactgctcc gccaatgtcg gtgaaaaagg cgatgtcgcc cttttcttcg gactgtcagg 2716801 aacaggaaag accaccctgt cggcagatgc tgaccgcaag ctgatcggtg acgatgaaca 2716861 tggctggtct gatacaggcg tctttaatat tgaaggcgga tgctacgcta agtgtattca 2716921 tttaagcgag gaaaaggagc cgcaaatctt taacgcgatc cgcttcgggt ctgttctcga 2716981 aaatgtcgtt gtggatgaag atacacgcga agccaattat gatgattcct tctatactga 2717041 aaacacgcgg gcagcttacc cgattcatat gattaataac atcgtgactc caagcatggc 2717101 cggccatccg tcagccattg tatttttgac ggctgatgcc ttcggagtcc tgccgccgat 2717161 cagcaaacta acgaaggagc aggcgatgta ccattttttg agcggttaca cgagtaagct 2717221 tgccggaacc gaacgtggtg tcacgtctcc tgaaacgacg ttttctacat gcttcggctc 2717281 accgttcctg ccgcttcctg ctcacgtcta tgctgaaatg ctcggcaaaa agatcgatga 2717341 acacggcgca gacgttttct tagtcaatac cggatggacc gggggcggct acggcacagg 2717401 cgaacgaatg aagctttctt acactagagc aatggtcaaa gcagcgattg aaggcaaatt 2717461 agaggatgct gaaatgataa ctgacgatat tttcggcctg cacattccgg cccatgttcc 2717521 tggcgttcct gatcatatcc ttcagcctga aaacacgtgg accaacaagg aagaatacaa 2717581 agaaaaagca gtctaccttg caaatgaatt caaagagaac tttaaaaagt tcgcacatac 2717641 cgatgccatc gcccaggcag gcggccctct cgtataaaaa acaaaagcca agagcaatta 2717701 tgctcttggc ttgttttaat tgacggaatg caaagaagtc agcttgtatg taatgatggt 2717761 ccggccttct tcccattgaa gcttctgcac ttcagctgtg cctgactttt cgccaaactt 2717821 tgttttgcgt acatccattg gaatctccat cggatatact cggtatccgt ccttctctaa 2717881 cgtgaatata ttttcatcta tgcgaacttc ttttcctttt gtcacaatca gtgtattaaa 2717941 ttcaacaggc attcccaaag tgaaatcccc tttcgttctc ttttttcttt atcataacat 2718001 atttcactgt cagcggtttt tcatccattg tgtgagctgc cgcacgatac gccggttttc 2718061 ttttggcggg aaataatgtg tgaatgtact gtagtaccat gtttccaccg gcttatgcag 2718121 ttgttttagc ttctcttcta ataaatagga atgctgaatc gaaacatttt ggtctttttc 2718181 tccatggatt aacagcacgg gagcctgaat tttgtttact tggtcaaacg gtgtcctcca 2718241 ttgatattcc tcaggcacct ttttcggtgt tccgccgatg actcttttca tcattcgccg 2718301 caaatcctgc cgctcctcgt atgtaagaat catatcactg acgcctcccc aggaaacaaa 2718361 tgaagctgcc tgcccgccca tttcgatcgc agtgagcatt cccataattc cgccgcggga 2718421 aaaaccgaag atatggattc tatccttctt gacatttggg tgctgctgaa gcaggcgaaa 2718481 agcagaaaat gcatcctccc tgtcttctcc ggcaaaatcc tcattgcctt ctcctccttg 2718541 attgcctctg taaaaaggag caaacaccac aaacccttgg gatgcaaact ggataatccg 2718601 gcccggccga accatgccca cgcttttaat cccgccgcgc aaatataaaa atccgtcata 2718661 ttgtcccggt tccgccggct cagccagaag ccccttaacc cgtaatccat ttgacagata 2718721 gcagatcgta tacaaacgca catgctggct tggcgacgga aatcttcttt tctctacaat 2718781 caaaacagcc gcctcctttt ttctatatgc tttccttact ccaaaattac atccggagaa 2718841 cctggttagg cattcacaca tttttatacc catcatacga tatgtaaagc aaaaaaggat 2718901 attaacttga tgcgaaataa ggaggttgtc tatgtgaaca gatggttaag gctgggcttc 2718961 gcctgtgtcg gcagtatctt tctgatgttc gccctggcgg cttgcaagca ggaagaaacg 2719021 ctcaccaaag tcaaagtagc tgaagtgacc cattcaattt tttacgcacc tttatatgtt 2719081 gctgagtcta aaggtttttt taaggaagaa gggcttgatg tcgatgtgaa tacgacctgg 2719141 ggcggagata aaacgatgac atcgcttctt tccaacggct ccgacatcgc gcttgtcggg 2719201 tcagaaacat ctatttatgt cgaagcgcaa ggggctaaag atcccgtcat taatttcgcc 2719261 cagctgactc agacagacgg aacgtttctt gtcgcgagag aagatgttga acacttcgac 2719321 tgggatcagc tgaaaggaaa aacgtttctc ggtcagcgaa aaggcggcat gccgcaaatg 2719381 gtcggcgagt atgtactgaa caaacataag attgacccgc ataaggatat agacctcatc 2719441 cagaacatag acttcgccaa tattgccaat gcgtttgctt ctggaaccgg tgagtatgta 2719501 cagctctttg aaccgcaggc ttctctcttt gagaaaaaag gcatcggcca tatcgtggct 2719561 tcattcggag aagaatcagg agaggttcct tatacgactt ttatggcgaa acaaagctat 2719621 ttgaagaaaa atgaagacac agccgtcaag tttacaaaag ccatttataa ggcgcagcag 2719681 tgggttgaaa atcattctgc gaaggacatc acagatgcca ttaaagatga atttgatgat 2719741 accgacccag acgtcatcga aacatccatt gaacgctata aaaaacagca ttcatattca 2719801 ccagaccctc tgcttaacga aaaagaatgg gagcttctcc aaaccattat ggataaatcg 2719861 ggagaactgc cgaagcacat tccatacaat cagcttgtaa ataaagaaat tgctgaaaaa 2719921 gtcacctcgg agaaatagga ggcgccatct atgtctttct tacatgtcga ccatgtaacc 2719981 catacttatt tttctattaa agaaaaaaca acggctgtgc gggatattca tttcgatgcc 2720041 gaaaaaggcg atttcatctc atttctcggc ccaagcggct gcggaaaaac aacattgctt 2720101 tccattattg ccggtttgat tgagccatca gaaggcagag ttctgattga aggccgtgag 2720161 ccgaatcaaa aagaacataa tattggctat atgcttcagc aggattactt atttccctgg 2720221 aaatctatcg aggaaaatgt gcttctcggt ttaaaaatcg ccgacacgct gacagaagaa 2720281 agcaaagccg ctgcactcgg tctattgccg gagttcggcc tcatagatgt ggagaaaaaa 2720341 tatccgaaag aactgtcagg cgggatgcgc cagcgggctg cgcttgcaag aacacttgcg 2720401 cctaacccta gtctgctttt gctggatgag ccattttccg cgcttgattt tcagacaaag 2720461 ctgtctttgg aaaacctggt attccgcaca ttaaaggaat atcaaaaaac agcagtgctt 2720521 gtcactcatg atatagggga agcgatagcg atgagcgata cgatcttttt attttcaaat 2720581 cagccgggca ccatccatca gatttttacc attcctaagg aattggccgc gatgttgcct 2720641 tttgacgccc gtcaggaacc ttccttccag acactgtttc aaacgatatg gaaggagctg 2720701 aattctcttg agaaacagca aagaaaccat tgatctgctt cacgagcagt atcaattcaa 2720761 acagaaaaag gaaaagtgga aggtccattc ctttcagctt gccatattta ttctcttttt 2720821 ctcgggctgg gaaatctcca gcaggcaggg ctggatcgat ccgctgatct tcagctctcc 2720881 atcagctgtg tggcgattat tgctggagaa acttggtgac ggttctttac tgtcacacat 2720941 cggcgtcact ttatttgaaa cggtgcttgg ctttttgctc gggacgttta tgggcacgtg 2721001 cctagccgct ttgttatggt ggtctaaccg acttgccaga attttagatc cgtatcttgt 2721061 gattttgaac gcaatgccga aagtggccct gggcccgatc ctgattgtcg cgctcggtcc 2721121 cagttttatc agcatcattg cgatgggagc catcatcagc gtcattatca caaccatcgt 2721181 tgtctacacc gccttccaag aggtcgacga aaactatacg aaagtcatga aaacattcgg 2721241 cgcaaaaaag tgggttattt ttaaagaagt catactgcct gcatcctccc ccgcgattat 2721301 ttcaacacta aaagtgaacg tcggtttatc atgggttggc gttattgtag gggaattcct 2721361 cgtttcgaag gtcggattag gatatatgat tatttacgga ttccaagtct tcaattttac 2721421 actcgtcttc ttaagcctgc tgatcatcgc catcttcgcc actctgatgt atcagggcgt 2721481 cgagctgctg gaaaagaaat ggacgaaggg gaggacataa aaaacccggc acatgtgccg 2721541 ggttttttat tcaatccatc cagattcttt cagttttttc aagctgatcg gaagaacgga 2721601 atccttcata ataaagctga attttttatt gcgggaaagg ttctccggca gctcgtgaaa 2721661 caaaaccggg cctttcgttt caaagtaatc agcctgcttt tcaagctttt ctatatctgc 2721721 aaaatatata ttttttacaa tcactttttc ttttccgaga actttatact gtccgagata 2721781 cttgaggctt ttgactctcg cgcccgtctc ttcctttact tcccggagcg cagcctcttc 2721841 tgcgcactcc atcggctcta ctttcccgcc tggaaactca tagcctctgt cctcatgttc 2721901 tgttaaaagc catttgccgc caaaacggca aatcacccag acatgcttcg ggctgtccga 2721961 gaaaggctga tcgtcaaagg aaagctgaac agtattctga taataatctt taaactcgta 2722021 catgtttatc cctcaaatcc gttcctagct atcttccata catcatacca cagttacgtt 2722081 tcttcggaag ccttttatca aaaaataagg gaaacccagc acgccgtcag gttctgcatg 2722141 cagactagct cgtacagttt ttttgcgata cttttgccgg aaagtgcgac cgacgctctg 2722201 ggctttatta tgacccgcga acagggaaaa gttacggttt gcgcttaaat ttatttttta 2722261 acgtttctaa aagatcgaca agcatctgag gaaccggtat gccaagagag ctggctgtca 2722321 caacaatttg cacagattca taaagaatat aaaacataat agccaagtca cgaattgatc 2722381 cctgtgtatt cagcagctga tcaaaaaagt ggcatacaga gatcagagcc agcgtgacta 2722441 attttttgac aagccgggca aatacctttt taaatgacag tttgtgaata atggtttcct 2722501 tcaaagtcgt actgataaat tcaattgcca taagagagag caaaatcaga aatgaatact 2722561 gaaaacctcc aaagaaaaaa cccgctgctg aaacgctgac tgctaaaaac gaaaagatgc 2722621 caaagtctct atccatttat cccaacatcc tttcacagaa acggccttac gatattctat 2722681 ggtaaacaag ccgaacggat tggatttttc agaaaaatgg actggttgtc gcctattttt 2722741 cagatacaaa aagaaaagcc ggacgtcttt tttaagacat ccggccgttc tatttttgaa 2722801 cttaacctag gtaagctttt agcatccagt tatgtttttc aatattttga tggatcgcaa 2722861 gaagcatgtc ccctgttgtt tcgtcaccga cttcatcagc taaatccatg ccgtttttca 2722921 gctcttccgc gatgactgtg aaatcatcat atacgctttg aaccatttgt tcagctgttt 2722981 catttccagc agcttctttg acagaagccg tttctaagga ttccttcatt gttgcaatcg 2723041 gttttccgtt cagcgccaaa agacgttctg ctaagtcatc aatataagtt gctgtttcgt 2723101 tgtacagctc ctcaaacttt tcatgaagag tgaagaaatc tttccctttc acataccagt 2723161 gataattatg tagtttcaca tacatgaccg tccagttggc tacttgtttg ttcactgctt 2723221 gaatcaattg ttctgacatg gtatctcctc cttgttatat gactatgtat acccttaata 2723281 tcgtacgcta aaacctcttt tttaccctta tctgtcacga tttcttctat tatgctacaa 2723341 ttgttaaaaa acgggaggtg gaatgtcatg acgcttctca ttacgataag tattttgatt 2723401 gtgctggctg ttttgcttgt aaccatttgg acgactgtaa aagcctataa tgtaaagcat 2723461 accattgatc caccacaaga aaatcactct gattcacaca atcaatgatg atgtgaatgc 2723521 tcctcttctg actgattgct ggcagcatcg gcgtctccga cttggacttt taaggtcggc 2723581 atgctatgct gtttttttgc tgtgacatga gattggacag tgtatacacc atcttcctta 2723641 aacgtcgttt ccaatcggta tacgcctttt tcttgtttca ccttaaacat ttggcttgcg 2723701 tctttttccc cttctttcca tacttcaaac tctacttcat cggcatccgt cacagcttca 2723761 tcaccatatg atacagctgc ttcataagca gcgctttctc cgggatttac tttttcaggc 2723821 ccggtcagct tgacatccaa aacctcgggc gtctcagctg tatttgcttt actttcacca 2723881 gatccgcatc cattaagcaa taaagcagaa aaaagcagaa caaccaacat ctttttcatg 2723941 ccatcaccct ttcatcgttt acctaaatag tagcaaacgc ttacagcaaa tggtacacaa 2724001 aatatgagac gtcacaaaaa agaccttttt gcttaagcgc aaaaaggtcc tttctatttt 2724061 agccaaatac ttttagcaat tcttctttat cctgtgaaag ccagaaacgc attaaacgtt 2724121 tagcgccttc cagatcatga agcttcgctt ggccgcactg cttttcattc gcagcaggta 2724181 tttctgtaat ctctaccgct tccttcattg tgtcttcaag cagatcaacg atttccgctg 2724241 atgtcggctc tccgctcaca actagataat agcctgtctg gcagcccatt ggagaaatat 2724301 caatgatatc aaaatgatcg tatttctcag cgtgagaacg aatcgtaaac gcgagcaaat 2724361 gctcgagtgt gtgaatggtg tcaggcttca tcgcctgttt atttggctgg caaaaacgaa 2724421 tgtcaaattt atttacaacg ccgtctgttc ccactttatg cacgccgcaa tgtcttacat 2724481 atggagcaac aaccgcatta tgatcaagct caaaactttc tactgaaggc ataatggcac 2724541 tctccccttt tttaaaaatg taatttcatt ataacatact tttccgataa gaattattga 2724601 ttaacttttc aatctgtgtt ttttttctta tacttgcatc agaaaggttg ctgaagaaac 2724661 atgaaaaccc tattcatcgc tctgatcaga ggatatcaaa aattcatctc gcccctgaca 2724721 ccgccaacgt gccgctttta tccgacctgt tcccaatatg gaatcgaagc gattaaaaca 2724781 catggcgctt taaaaggcgg atggctgaca atcaaacgga ttttgaaatg ccacccgttc 2724841 catccgggag gagtcgatcc cgttcctgaa aagaaacaaa aacattaatt gttataaccg 2724901 tttacgataa gatccagttt tccggtttta ggatcaatga ctaagccatg gaccggaacg 2724961 ttttcaggga acagcgggtg atgtttaata acatctacgc tgtctttcac actcgcttcc 2725021 actgaatcaa agcttttaaa ccattgatca aagtctacac cggagtactt tattgtttcg 2725081 atgcgttctt ccggaatccc tcttgctttg attttttcaa gcatgctttt gctgctgatt 2725141 ttgctcatgc cgcaatcgtg atgcccgatc acacacacct catctgcatt cagctcgtac 2725201 actgcgacga gtatacttct catgatgctt ccgaatgggt gtgtcacaag cgcaccggca 2725261 cttttaatga ttttcacatc accgtttcgc aaattcatcg catgcggcag cagttcaacc 2725321 agacgagtat ccatgcaaga aagaatcgcc atttttttat ctggaaattt tgatgtttga 2725381 tacttttcat actctctttg ttcagtaaat gtcttgttaa attcgagaat atcatttaga 2725441 agactcatgt tcgttgtccc tttctattct ttttactctt caatatatca caacccttgt 2725501 ttattcgtca taataaaaaa agacaaaccc tcaggcctgc cttatttccc catgttatag 2725561 cgttttttga actgctcaac tcgtccgcct ttttcattga atttctggcg gcctgtataa 2725621 aacggatgcg tgtcagagct tacctctact ttaatgacag gatatgtgtt tccgtcctcc 2725681 cactctgctg tttcattaga tgttttcgta gaggtgctta gaaaacggta gccgctgttg 2725741 acatcctgaa atatcacttt gtggttcttt ggatgaattc cttctttcat gggtatctcc 2725801 tttcaataaa tcgtaataat tacgttttat tttataacct tacaaacgtt ttgtcaatct 2725861 tcttatatcc ttccctctgt ttcacatcgt aaacctcatg gcatttaaga ataggaagaa 2725921 taatctaacc gaggaagcaa ataataaacc caaaatacat acagaacgtc tttttggaaa 2725981 ggtggtttac gattgtggat gatttagttt tggccagaag cctttttggc acgacgatgg 2726041 gctttcatat cattttcgca acacttggag tcggtctgcc gctcatgatt ttagtggcgg 2726101 aattgatcta tcaaaaaacg aaagatgacc attatgcgat catggcgaaa agatggacga 2726161 aagcacaagc cgttttgctg ggggtcgcca taccgaccgg aacgatcgcg ggcactcagc 2726221 tcgcgctttt atggccggga tttatggaag tcatcggccg ggtgatgtcc ctgccatttc 2726281 aaattgaaat ctatgctttt tttgttgaag ccctattcat gtcgatttat gtatacgctg 2726341 cagaccgttt gtcacctgca atgaggattg ttgctgtttt ctttgtgtta gtcggggcag 2726401 cagcatccgc tgttctgatc acgaatgttc acgcttttga aggtacgccc gccggtttta 2726461 aaattttaaa cggaaaaatt acagatgttg acccgtgggc tgcgtttttt aatcctagct 2726521 tttttatcac tgccggccat gtcgtgctgt ccgcgtttat gactggtgcg tttatcgtgg 2726581 cttctgttgc ggcgtataaa atgatccgaa cgaggaaaaa ggaaagggtc tatcgctttc 2726641 accggaaagc ccttttgctc gcactgacga tcggcggtat tttttcattg ctgaccgctt 2726701 tgaacggaca cgaatctgca cagatgctgt acgaatacca gcccgaaaaa ttagccggtg 2726761 cggaaggcct atttgaaaca agatcccacg ccccgctcgc tatcggcggt tttaccgacc 2726821 cgaatgaaga aaaagtaaaa tgggcaatcg agattccatg ggctttaagc tttttggcag 2726881 cgaaccgttt tgacactgtt gtaaaaggat taaatgcatt tccgagagat gaatggccgc 2726941 cgcttttcat tcacacgctg tttaatgcga tggttggtgt aggcatgctg ctaattcttt 2727001 attccattat cggtgtggtc tggagaaagg tgctcaagaa agaccgtttc ccaacgtggc 2727061 ttttgatcat tttcatgaca gcaggccctt ttagtctcat cggcattgaa ttcggctgga 2727121 ttttcgcatg tacggggagg cagccttggg tcatctatca tctgctgaaa acgtcagatg 2727181 tcgtaacaac gactggctcg atcggggtgc tgttcttatt tttcacattt gtttatgccg 2727241 tgttaggcgc agctgtcgtc tacgtgctgc tgtattattt ccgcaagcac ccggttgacg 2727301 aagatttaaa tacagcggag tcgtaatggc tccgcaaaca ggaaaccaaa tggaaggaag 2727361 atcgtacaaa tggagatttc aactgacgct ctgatcgcca tctcaattat ctggggcttt 2727421 gtgtttattt acgccgtcat ggcgacaatg gattttggag cgggattttg gtctatgatc 2727481 tatttaaaca aggagcatat gaaggccacc gatattgcga atcgcttttt gtccccgact 2727541 tgggaggtca caaacgtctt tattgtggcc atcgtcgtgg cgcttttcag ttttttcccc 2727601 ggcgcgacat ttgtgctcgg caccgtttta ttaattcccg gaagcatgat tttgctgctt 2727661 ttagcaattc gaagcggatt tctcgtgttt tcaaatacag caaaggagcg gaaaacgcta 2727721 agatatattt ccggcatctc cggctttatc attcctgcta ttttaatttt ggtgcttcct 2727781 gtgacacacg gagggtttat agaaaaaacg gatggaatct ataacttaaa tatgtctaaa 2727841 atcttttcaa gccccaacgc ctattcattt atcgggtttg cgattttaag caccttattt 2727901 ttgtcctcgc tgttgcttgc agatttttca aatgtggcag aggaacagga tgcgtaccga 2727961 gcctacagaa aaagcgccct gattaccggc ccgatttcac tgttgtttgc tgtatgcatt 2728021 atggtaacta tgcggaatga agcaaactgg ctgtacagcg gaatgatgaa tgatttttct 2728081 tggattattg catcgttcat tacatttgtc attgctggaa tcgctctttt tctgcctaac 2728141 aaaagctttg gtcaaaacat cggaaaaccg cgtctcgcac ttgttgcgat tgggatacag 2728201 tattttctcg caagctacgc gtacgggcgg gcgcatcttc cgtatatgat ttatcccgat 2728261 gtgacagtca tgtcaggctt cacagagcca gcaacgttca gagcgctgtt tgcaacgtat 2728321 atcgttgcat ttatcattct atttccgggc ttctttttct tctggaaaat gtttatgcga 2728381 gataaacgct atatccgcca ggaggaatag agggcaagcc agccggctat actaatccag 2728441 aacctttata aggaggggat ggcatggagc agaaaattct atgtgaggtc aacaactgtt 2728501 cttattgggg caaaggtaac aaatgcaccg ctgatgccat ttatgttgtc agccatactg 2728561 gtgaaacggc tgaaaacagc cgggaaacag actgcaaaac gtttaagccg catgatttat 2728621 aattaaaaga aagagctgca tcagccagct ctttcttttt gcatgttgag tgttctcagc 2728681 tttttagtta tgaccccgtt tgcaggtgaa aacaaaaagg cgcttgcata acatacacct 2728741 gtcatggccg ccatcgctcc tgaaatcgaa acattaagcc acgttgcgaa gaaatagccc 2728801 atgaccgccg acagcccgcc aatcaacgcg ctgagaatca gcatataaag aagccggtct 2728861 gtcagcaaat gtgccgcagc cggcggaaca atcagcatgg ccacaaccaa tacggcaccc 2728921 accgaatcaa aggaagcaac agtcgtcaag gacagcatgc ccatttgcac gtaatgaatg 2728981 agcaaaaccg gtattcccaa ggctaaagcc atttgaggat caaacgaagc gattttaaac 2729041 tccttatagc acacactgat caacactacg tttaaaacca gaacagatgc cagcatccaa 2729101 aacgctttcg gcccaatatc aaccccgaat accgtcaccg tattccacgg cacaaaagcg 2729161 atttctccca ttaacgagtg ctcaatatcg agatggacat tcgctccata cacagaaagc 2729221 aaaataaccc cgattgcaaa taaggatgta aacacaactc ctatggcagc atctgattga 2729281 acccccttgc tatgaagaag ctgaaccaag aaagccgtta acagaccggt tgcggctgcg 2729341 ccaataaaca tataaatccc atcgagactt cccgtcacta gaaaagcgcc gacaatgcca 2729401 agcaacactg tgtgactgat tgcgtcggcc agcatcgcca tgcttctcag cacaagaaat 2729461 gtgccgatca atccgcagct tacaccgact aatacaccgg tagctataat ccatgcttca 2729521 aaactcattt gcgatctgtc ccttctcggc atcatgagac gcttttcgac gctcaggcat 2729581 ccgtccatac agctttaaga gtgaataaag ccgctctctc gtttctctcg gtaaacggtc 2729641 cgggtcaaag tagtcctgat cggattctat attggcaagt tccatttcat gcatgagata 2729701 cacttcatac atccgctgct tcaaagctgt gtgatagcct ttttctatcc ctttgcttgt 2729761 gatttgccaa atcccatttt cgatacgctc aatgcacctc tcttgttcca agtcatttaa 2729821 tgccttaagg cataatgaag gggataggcg tcttttcttt cttacacttt caacagttac 2729881 acaaagatta ttcttttcat actgttcata aatcgccaaa agcacttgct ccctgcttgt 2729941 tctgcgccgc agcctcatca gccttatggc tttagcagcc aatccccgct taggcgcgca 2730001 aatcattgaa aaaagaaaga gcagcgttgc agataagatc attaatggcc ctgtcgccat 2730061 tcccttcatc gtggtgctaa gcagggttcc ggccactccg ctgaccccgc ctgtaatccc 2730121 ggcaatgatg atcatcccgg ttaatcgttc ggtccaatat ctcgcggtta tggcaggtgt 2730181 aatcagcata gccgccatta atatcacacc aacagtctga agcccaatga cgacagcaca 2730241 gacaatcaga caagccaaaa gcccgtttaa aaaacgcacc gggattccta atccctttgc 2730301 aaacgcgaga tcaaaagtaa tcaatgtaaa ttccttaaag aaaacaatac ataggagcag 2730361 tagaacagcg gatatccctg caataaggat gatatcctgc ctgaccaatg aagcagcctg 2730421 gccgaataaa aaagaatcaa gcccgctttg gcttcccgcc ccctgttgct gaatatatgt 2730481 cagcagaatg atcccgacgc caaaaaacac agaaagaaca atcccgatcg ccgagtcctc 2730541 ctttgttttt gaaagccgag gaatcagctg aatacaaaac gttccgagca gtccggcgag 2730601 cgctgccccc agcaaaaaga aaggcagtga tttttgcccg gtgaacagaa aagcgagaca 2730661 cactcccggc agagctgaat gggccatcgc atcgccgatt aaactttgct ttctcagcag 2730721 cacaaagctg cccaaaacac cgcttgccgt cccgagcaaa agcgtaccgg ccagcaccca 2730781 ctgtgtattc ggatgctgaa gctgcagcca caaactttca aacattgcgc tcactcctta 2730841 tgtccttctg ccagcacttt atcttttaaa aacgtaagcc ttcctccata tgttttttgc 2730901 aggttttcga tcgtaaaaac gttttccgtc ggtccgaaag cgattttcct taaatgaagc 2730961 agtaagatcc aatcgaaata atcctcggcg gtctgcagat catgatggac gacaagcacg 2731021 gtttttcctt tttctttgag ttctgccaac agcgtcataa tcgcgcgctc cgtcgctgca 2731081 tcaacacctg caaacggttc atccataaaa taaatgtcag cgttctggca gagtgcccgg 2731141 gcaagaaaca cccgctgctg ctgtccgcct gacagctggc tgatttgcct tttcgcataa 2731201 tcatgcatcc cgacttttgt taatgcggcc ttcgccatct ccacatccgc tttctttggc 2731261 ctctttaata aaccgattct cccgtatctt cccattagga cgacatcgag cgggcttgtg 2731321 gggaaatccc agtcaaccga gccgcgctgc ggaacatatc cgattctggt ccgctgatcc 2731381 ttatagtctt tgccgtaaat agagatgtct ccggaagctc tgggcacaag accgagaatc 2731441 gttttgatca aggttgattt tcccgcgccg tttgggccga taatgccaat aagttttcct 2731501 tcaggcacct gcagcgaaat gtcctgcagt acaggctttt tatgataagc aaccgtcaca 2731561 ttatcaagct caacagggaa catatcctcc acctcttttc tttatttaag cgctttagta 2731621 atcgtgttga tattgtggcg gaacattcct tcgtatgtgc cttcttttgt gcccttttca 2731681 cccatggcat ccgaataaag ctgaccgccg attgtgactg tatggccttt ttctttagcg 2731741 ccttccacca ctgcattgat tgatttttca gatacactgc tttctacgaa cacagctttt 2731801 atttgttttt ctgtcagaag atcaaccagc tcctgaacat cccttaatcc atagtccgaa 2731861 tctgtgctga gtccctgcag gccttttacc ttaaatccat actcattccc aaagtacgca 2731921 aacgcatcat gagcagtcac aagcacacgg cttttctccg gaatatgtgc gatctcctta 2731981 cgcgaccact tatctaaata ttgcaaatct tctttgtact ctttggcatt tttccgaaag 2732041 gcatctgcgt gctgaggcat tgctttgctg aattgcgctt caatttcatc caccgcatag 2732101 atccataacg gaatgctgaa ccagacgtgg ggatcaaacg tcttgccttc ccccgcggga 2732161 ataagcttat ttttcggaat ggcctcagct actgccgccg attgtttttg ttcgccgatt 2732221 ttttggagga catcctccat tttcccttcc aaatgcaacc cgctgtacag aacaacatcg 2732281 gcagacatta attttttcgt gtcaccttgg gaagctttgt aaaggtgcgg atcaaccccc 2732341 ggtcccatta aagaggtgac ttttacgtgc ttacctccga tgttttctgc tgcatcggca 2732401 atttgagatg ttgtcgctgt cacttgtaat tgctgatcag cgctttttcc ggctgaatcc 2732461 gttccgcatc ccgttaaagc aaaggtcgca aaaagtactg ctgccatcag cccttgtctc 2732521 atatttctcc tcctctttgc catcaatgtc cgattgtttt atcttatgtt gtcagttctt 2732581 agacatgtga cattaaatta gccaaaagca tgttttattt acacaggaca aaaagtttcc 2732641 ctcatgcaaa attatcgcgt ttggccattt ttgtcaagct gatttacata aaaaaaccgg 2732701 ctgggtcagc agccggtcca aacgagaagg gatgtattca acgaacactt ttactgtaac 2732761 agcacagtgt catttattca aaatagcaaa atgctttttt cttaaccatg ctgtgtgaaa 2732821 acatccattt tggtcacata ttttcgcata atatcttggt ttacctcaac ccctaaacca 2732881 ggctgttttg acacagaaat aaatccatta tcaatacgaa tatcaggagt tacaatatct 2732941 tcatcccaat agcgtgagga tgaagatata tcgccaggta ttgtgaattg aggcagtgaa 2733001 gcaagcgcca cgttctgcgc tcttgatatg cctgtttcca gcattcctcc gcaccaaacc 2733061 tgcatatgat gctctttgca taaatcatga atttttaagg cttctgttaa gccgccgaca 2733121 cgagaaggtt ttatattaat aattttgcag cttcctagct caatcgcccg tctcgcatca 2733181 tcaactgaac aaatgctctc atcaaggcaa atggccgttt tcaaatgttt ctgcaagtgg 2733241 cggtggtcaa cgatatcgtc agcttggagc ggctgctcaa tcatcattaa atgatagtca 2733301 tcaagctcct ttaaacggct gatatccttc agttcgtaag aggaattggc atcggccata 2733361 agcgggatgg ttgggaatcg gctgcggatg gccttgacca attccacatc ctgcccaggc 2733421 tgaattttaa tttttattct ttgataacct tctttttgat agctctcaat ttccttcagc 2733481 atatcgtcaa gaggcgccag gccgactacc accccggcag ggactttatc tcttgttccg 2733541 cccaatgcct cagcaaggga tacgcccttc tttttggcat aaatatccca tacagccgat 2733601 tcaagtcccg cttttgccat ccggtttcct ttataccgcg ccaggctgtc cggcacttct 2733661 gaagggtgat tgaattcacg gccgacgaca tttgggataa aaaaatcttt tagcatatgc 2733721 aaacatgttc caatggtttc ctcggtgtac caaggcgaag agaaagcgga aacttctccc 2733781 cagcctgtga cacctgatgt atcaatggct tccacgatca gaaatttacg ctcttgaagc 2733841 gtttcgatac tgtttttaaa cggtttcttt aagttcatgc tcaaatggta aagcgtgatt 2733901 ttttctattt cgatcatagc agttctcctt tacgcgcatc cttcagctga tttcgcaaga 2733961 gcttattaga cgcattgcgc ggcaggcggt caagcacaaa gaattttgcc ggaattttat 2734021 acttcgccaa gcgttctttg cagtagtcag tcaattctcc tgcgctcaca ggcttgtgaa 2734081 ggacaagata ggcgtgaggc actttccccc attttttgtc ctcagcccct gaaaccccgg 2734141 cttcggccac agcggggtgt gaaagcagca ctgactccac ttcggccgga taaatgtttt 2734201 ctccgccgga tatgatcaga tctgaacgtc tgtctaatac atataaaaag ccttcattgt 2734261 ccaaataacc aagatcacct gttttcagcc agccattttg aaaggaggct tcgtttgcgc 2734321 tctcccggtt aaaatagctt ttcatgacat tcgggccttt gaccatgatt tcaccgtgtt 2734381 catacggttc acatacctgt ccgtcccgct ctattttgat ttcacacgaa aacagcggtt 2734441 tccccgcaga tccgagcttt tccatgctga attccggcga cagggtaaca atttgcgagc 2734501 atgtttctgt cattccatat gactgaaaga cagggaatcc tttctcacgg cattcctcaa 2734561 gcaatggcag cggtgcagga ccgccgccga gaagaatgca tctgatggat tcagggcagc 2734621 ggtttgtttc ttccaaaaga ctggccagca tagtctgcac cgcagatatc attgtcactt 2734681 catgcctgtt gatagaatgc agcacatcgc ttacggaaaa acgctggtga agcacgacag 2734741 tcattccata gatcacagat ttaaataatg cggacaatcc gctgatatga aagagcggca 2734801 atgcgataag ccagcggtct tgttctgtta tacccaaatt aagagcggac gacaccgcac 2734861 tgaaataatg gtttccgaac gtttgctgaa ctcccttggg ctttcctgtc gtacccgacg 2734921 tatacatcag cgttgccgtt gcatccattt gcatataagc ctcgatctca atttcctctg 2734981 ctgcttcttt catcagttca tccacatcaa tcgtttgaac gatgtgttca tattctttct 2735041 tctcaaagct tgaatctgtc aataaaaagc cggatcccga atcctccagc tgaaacagcc 2735101 tttcatgtgt tgacagcttc gtattcaaaa gcaccgcctt aacaccaagc aaaaaacaag 2735161 cgtgaacagc gtataccatt tctgcacggt tttggagcaa aatagctgca gtatcccctt 2735221 tccgaaccga atgagcggca agctgttccg ccattcgttt agacgcggca aacaattctg 2735281 caaatgtcac ggtttggtct tcatagatga gagcgattct ctcaggtgtc agctgtgccc 2735341 gctgcatgag ccagttgggc tgttctgtca gcatgtcatc atctccgagg taaaatgtct 2735401 gtattgaaaa gaaaacagct tggaccgcaa agtctcaagc tgttggttta ctagatattg 2735461 ctgatcacgg aaaacgaggg aactgtccga aatcaggttt gcgtttttcc ttaaaggaat 2735521 cacggccttc ttttgcttca tctgttgtgt agtaaagaag ggtagcatcc cctgcaaact 2735581 gctgaattcc agcaagtccg tctgtgtccg cgttaaacgc agctttaaga aagcgcagtg 2735641 cggtcgggct tttttcaagc atttcttcac accatttaat cgtttcttct tcaagctgtt 2735701 ccaaaggaac gactgtgttg acaagaccca tgtccagtgc ttcctgtgcg ttgtactgac 2735761 ggcataggta ccagatttca cgtgcttttt tatgtcctac aattcgagcc aggtagccag 2735821 aaccgtaacc tgcatcgaag cttcccactt tagggcctgt ttgtccaaaa attgcgttgt 2735881 ccgcagcaat tgtcaagtca catacgatgt gaagcacatg gcctccgccg atcgcatatc 2735941 cggacaccat cgcaacaacc ggtttcggga tgacgcggat taaacgctga agatccaata 2736001 cgttaagacg agggatctgg tcgtctccta catatccacc gtggccgcgc actttttggt 2736061 ctccgccaga acaaaatgct ttgtcccctg caccggcaag cacgataacc ccaacgtttt 2736121 ggtcgtctct tgcgtcagca aacgcatcaa tcatttcagc aaccgtttta ggggtaaacg 2736181 cattatgtac ctcaggtcgg ttgattgtta tttttgcaat gccattatac gtttcataca 2736241 atatctcatc gtatgtccgt tttgttttcc attcagccat atgatgacct ccttttattc 2736301 tctatgtgaa tgagtcagat gcttgtcaaa aactcactca ctattttacc aaacaatcgc 2736361 ggctgctcca catggaccgt atgtcctgct tttggaacaa tctctattct actagaagga 2736421 agcatcttat gcacctcttg attgatggcg caaaattttt cgtcccactc cccgcagatc 2736481 agaagcacag gaacatctat ttcctctaca cggctccaca aggaaggctg tgaaccggtg 2736541 cccatgccgg ttaaactgtt cgcaagccca atcttattgt tccgcagacg gcccgatcgt 2736601 atcctgtacc gaatatcttc agccagcctc tgctgagatg aaaacaaagg gatattctcc 2736661 caatacgcaa caaacgcttc gagcccgtct cgtaaaataa aatcagcaag cttccggtcc 2736721 cgcatgattc gttcccgccg ttccccaagt gttttgagcc ccggcgtcgt gctttcaagc 2736781 acaagtgccg atacccgctc gggatatgtc atcgcaaaag agtaagcaag ccttcctccc 2736841 atagaatacc caatcaattt cactttgtga agttttaatt gatcaaaaat ctcggcaagg 2736901 tcagaaactt gccgggttgt gctgtatctt ttcccattca gcggggcatc ggtttcccca 2736961 tgccctaaac aatcaatttt gatcaaacgg gaatcaggca gcatttcatc aagaaaagtc 2737021 catgattgtt tgctgccggt aaacccatgc agacagacga cggcttcgga agcattcggt 2737081 ccctcgtctg ccactgcata tcggacacca tctgataccg ttatgtttac agttcccatt 2737141 gttttttcac ttcccgcaca gcctcattca gcatatcgcg atgaagctgg actcttgatt 2737201 ggcgatccgt tttgatttca atcaaatgga gtccgggctt gtctgcctgc ggcgcgtaag 2737261 ctgttttgaa ttcatcccaa gaagccgggc atgaatacgt tccgccgtaa agtgcagccg 2737321 catgcttgaa atcgagccct gtcggtgtgc cgaacaaatc ttcaaagtgt gtcttctcag 2737381 aagcctgcgg caaaaaggag aaaatccctc ctccgtcatt attgacaaga atcacagtaa 2737441 gaggaatacc cagctttttg gccgccagca ggccgtttaa atcatgataa aaagataaat 2737501 ctccaatcac aagggtaaca ggcgcttttg ttccttcaca tacccccatg gcagaggaga 2737561 cgacaccgtc tatcccgttt gctccccggt ttgaataaat ccggaaaggg cggtcctgct 2737621 tttcaaaaaa cgtatcaaca tccctgatcg gcatgctgtt tcccacaaac agcgagctgt 2737681 tttcaggcac aagatgctga aggattcgat agagattgcc ttcaaacgaa acatcttcac 2737741 tgctgattgt ttgcagatgc tcgcggaacc gcccattgac aaactgccac ttttccagcc 2737801 actctgagga tctggtggca gcagtaaggc ctgccatgat ctcctcagca aaaacagacg 2737861 cattacaatg aatcatatgc gcgcttgcct gtgtcgggtc tctccaccct ccatcctcgt 2737921 caatcacgat ttgctgaatc gtcggatcat ccttaagcca taagaaaacc ggttttgaaa 2737981 caggcatcgg tccaaaccga atgacaacat caggacggag tttccgcttc agctcatcat 2738041 cttttaaaaa cgaatcatac gcatcaataa cagtgctttt atcatgaaca ccattccgca 2738101 gattagacag cggatctgct aaaattggat actgaagcgc ttttgacagc gcaataatgt 2738161 tttccttgtc cgcatcacta tggagctctc cgcagacgat cattcctttt tcagcctctg 2738221 cgagcatctc agccacatca gacagggact ctcggtcaac agactgcgta cccgttttca 2738281 cagacacatg acggcctgtt ctcattcttc caaacggctc atctgaaaga tccggcatca 2738341 gcggttcgcg cagcggcaca ttcacatgga caggccccat cgggcgcttt tgtgcttctc 2738401 cggcagcgcg gcttgccagc gttcggatgt atctcagcat ttgcggagac tcttcaggaa 2738461 gagcagagtc tgtgaaaaac ttaacaaagt taccgaataa gaagtgctga ttaatagcct 2738521 gcggtgcgcc tacttcgcgc agctcatgag gccgatcagc agttaacaca ataataggca 2738581 cccttgaata atgggcttca accacagccg gataaaagtt ggccgcggct gttccagatg 2738641 tacagatcaa tagtacggga cgctgcttcg cttttgccaa acctaatgca aaaaatccgg 2738701 cagacctttc atcaatttgg acatggacgc tgatatcggg atgcgcagca caaagaacag 2738761 ccagcggtgt agatcttgag cccggacaaa cgacggcgtc cgtaattccg gaaagggcga 2738821 attcatcaat aaaacttccg atgtaatgag taatcgggtt gactgtcaac gcctctcacc 2738881 tcctaatgca gagatcatcg gcttcaattt aatctgtgtt tcttcatatt ccgagattgg 2738941 ttccgagtct tccacaatac cgcacccggc aaacagcctt gctgtgcttc cttcgatgag 2739001 ccctgaacga atggcgaccg cgaattcccc gttatcctgg ctgtcaatcc agccgatagg 2739061 ggccgcatac cagccgcggg acatcggttc aatctccctg atcacgtcaa cagctttttc 2739121 ctgaggtgat cccccaagcg cgggagtggg gtgcagcttc tcaattaagt caaaaatcga 2739181 agcagactcg cgcagctgtc cgacaatcgg cgtaaacagg tgctgaacgc tttttgtttt 2739241 gtacaaaaca ggtccatcag gcttttcaac ctctgaacag cttgatacaa aagcattatg 2739301 aatcatacct accacaatat catgctcaag caggtttttc tcatcgttta ataattcaag 2739361 gcctatccgg cggtcgtctt cttcattcac gcctcgttta atggagcctg ccagacagga 2739421 agacatgaca gtgccgccgt ctcttttgat cagtctttcc ggagacgcgc cgacaaaggt 2739481 tttgccttct tgttcaattg caaaaacata gcttgtctgc tgatcgtcca gaagcgtttt 2739541 aagcaccggt tcaatttgga ttggaccgtc aaacgtgagc agcagctctc gggcaagaac 2739601 aaccttatca tattgtttct ctttaatttg gcttgtggcc gtttcgattg ctttcagcca 2739661 atcatcctta tccagctctt cggctgctgc aatcacagcc tgatcttctt gcttgaaatc 2739721 gggaaccata aattccgccg caaaagcttt taagccttct aaaacagctt ctgcgtcttc 2739781 tcctccgctt acccatctgt taactgttaa gaacgggcct tcagcagtca tcgtcagcat 2739841 aagcgcaggc acaaagaaat ccccttccga gaaatggtcc cattgtgaac ctctttcttc 2739901 gcaagggtca aaagaaaatc ctccgaataa cacaggtccc actgcagaat gctgcagctt 2739961 ttcttcttca taaatatgaa aagccgtctt tttaaagcgc tcccattgtt caaaaacctc 2740021 acgataccgc tcgctgtttt tttgatttgt ctggaaaacc gcttctttgc caagaccgac 2740081 tattgtcaat tcactttcag gatctgacca aaaaaatcga ttgcctgtat atttttttgc 2740141 tccgtaattg aaaaatgata gagggtcaag agactcgatt tgtctcgaat agcttattaa 2740201 gacagcatgg ttgacttctt tggctttatg taatgcatgt agaacttcct ttcggaacgt 2740261 acgctgcacc gttgtcacca tgagacattc ctccataatc cttaaaatgc ttttaatacc 2740321 atacacctgt gtctcctttg tgtcaaacac agatcatgca gtccaaatgg cctgccttac 2740381 ctattataaa cctaatttca gaaatgaaaa agaaacaaag cttaaatttc tttctccact 2740441 gatagcaaag gttgtatccg cttaccataa aaggaaaacc tcctatattc ctccacccgc 2740501 catttatgaa agttctcagg cgatctgttc atactaaagg tatgcatcac agagaaacga 2740561 ggcgatcaca ttgcttacga aagaacagct tcagcattta aaaaatgaac tggaacaaac 2740621 gaaaaaagat atcttaaacc gtttcaaaga caatgatcat tttcagctta actcagcctt 2740681 tccttatgat tcgtggggtg agctttcggc atacgacaac catcccggcg atcaggcgac 2740741 agaactttac gagcgtgaga aagacatcgc tctagacttg catgagagag agcaccttcg 2740801 ggacattgag cattcattga aggcgataga aaacggtacg tatggcattt gtgaagtcag 2740861 cggaaaggaa atccctttcg aacgacttga agcgcttccg actgccacaa ccctcgcgga 2740921 gtattcgtca caggacgtgg tttccaaaga ccgtccgatt gaagaagaaa caccattcgg 2740981 gcaatttgaa tttgatgatg atgaagaaat cagagcgcca tatgacagtg aggattccta 2741041 tcaggatgtc gaaaaatatg ggaactcaca aacgccgcag gatatggaaa accctccgct 2741101 cagctatgat gatatgacga tgaatgccga agagaatatc ggcaatacgg agtcttacga 2741161 aaatttcatc gctacagata tcactgggaa agaaattacc gtttatcaaa gcagagccca 2741221 tgagcgctat gaagaagaac ttgacgaaga gggaatcatg accacattcg gcgatctcca 2741281 cgctgattga acccccaatt attgggggtt cttttccgtt ttcagcatat cgtaaatcag 2741341 cttcagataa tccttttgca ggccgatgtc ataccgctcg ccctctagca atttcccgta 2741401 tacggtacat gccccgagcg aagcttttat cgcatccgtt acctgcactt ctcctccgct 2741461 atcagcttct aatgcctcca gctcattaaa aatatccggt gtgaaaatat aacgccctgc 2741521 tgcggcaaaa tgagacggag ggttttgttt aggcttttcc acaatatcct gtatgcgata 2741581 aagccctttt tcaacaggct ccccttttat caccccgtaa tgatgtaaat cctccgtttt 2741641 tgtttctttt aagccgatca cactggactg atatttcgta tacgcttcaa tcagctgccc 2741701 caaagccggc tgattggcgg aaaaaatcag atcatctggc aaaacgacgg caaaaggctc 2741761 tcctcctgca aattgctttc cgaaagaaat ggcgtcgcca agaccctttg cataaggctg 2741821 ccgcacatag tgaatccgta tatccggaat gggatgctct ctaagtaaat gcagtttatt 2741881 cttagaggcc aaaaaagcct caagtgccaa agaggaatca aaatagtcga caatcagatt 2741941 tttatggctc gatacaacca tcaaaatgtc ctcaatgcct gactccttta attcttcaac 2742001 aagataatga atcacaggct tagatcctac cggaaacatt tctttcggaa tcaccttcgt 2742061 caccggcaga tttctcgtgc cgaatccgcc tgcaggaatg atcgcttttt ttatcatggt 2742121 attttcccct cagctcatgt ttattacatg atattccaag agcgcatccc gatgtttgta 2742181 catctgaaat taggcggaag caactgggca gaaagcggaa tcacgaacca gccctttttt 2742241 aataggatat tgatatatga ccagtaatct tgtaaaggag ctcaggtgat gaaaatttgt 2742301 gtggttggcg ccgggtatgt cggtttaacc ctatcagcgg cactggcatc catcggacat 2742361 gacatgatat gcacagacaa agacgtcaaa aaaatcgggc agctgaaaaa aggagtcatt 2742421 cccttttacg agcctgggct ttcagatgca atacttcgtt gcggcaatct ctcgttttct 2742481 tctgaagtga aatcgagcat ggaggaatgt cccgttattt ttatcgcagt cggaactccg 2742541 ccgcgttcgg acggatcagc tgatacgaaa gccctgcagt ccgtcatcgg tgatttaagc 2742601 gaggcgatcc gatcgtataa aaccattatt acgaaaagca ctgttccgcc cgggacaaat 2742661 gaaaacatag caaaacagct gattgcctcc ggagtgtcta aaaacctctt taatatcgta 2742721 tccaatccgg agtttctgcg ggaaggcaat gccttatatg acatgctgca tcctgacaaa 2742781 acagtcatcg gtgttcagga agaagatcac gtatcggcag ccatcgtcaa atccatttac 2742841 aaacacattg ataccccttt tatcgttaca agcttagcgg gagcagagct gatcaaatat 2742901 gccaacaatt tctttttagc ggccaaaatt tcgttcatta acgaaatggc ccgcatatgt 2742961 gaagcctatc aatcagatat ctcagatatt tcccgcgcta tcggtctaga cccaaggatc 2743021 gggaagcact ttttgcaggc aggcatcgga tacggaggct cttgttttcc aaaggatctg 2743081 caggcgctgc aatttgctgc ccaggaaaaa aacacggaga ccttcctgct ccgggccgtg 2743141 cagcacatta atgacaccca gcttggcctg tatatcaaaa aaatacagtc attcttcgaa 2743201 acacttcaag gcaagaaagc ggctgtactc ggcatttcct tcaaaccgaa tactgatgac 2743261 atccggaatt ctcaggctgt cagactgatg gaaaggctgg cggagctggg atgtgatgtt 2743321 catgcatatg atcctgaagc tgtacttcca gaacatttgc ggcaacatgt aactcagcat 2743381 tctcaagctt ttgatgcgat cgaagagagt gactttttat ttttggcgac agaatggtct 2743441 gagtttttag cgtttgattg gaaaaaggct gcagatatca tgaaagggcg tcttgtgatt 2743501 gacggacgca acgtactaaa aaaagaactg atcgaggctt gcggcctgat ctgtacggga 2743561 gttggccgtc catgaaaata ctcgtcacag gagcagcggg ctttatcggc tcccacctct 2743621 gcgaagaatt actaaaagat aagaaacata acgttatcgg aatcgatgac tttatcggtc 2743681 ctactccatt ttccttgaaa ttaaaaaacc ttaaaaacct gctgccggaa aagcgattta 2743741 cgttcataaa ggaaaatctg ctgacagccg atcttgcttc cttactggaa ggagtggacg 2743801 tcatctttca tttggcggcc ataccgggtg tccgctcaag ctggggcaat cattttcacc 2743861 catatgccgc acataatatc caagcgctcc aaaggctcct cgaggcgtgc cgggaacatt 2743921 ctattcaaac gttcgtcttt gcatccacct cttccgtcta tggcgaaaaa caaggaaaag 2743981 tcagcgaaaa cacgtcgctt tctcctttat ctccgtacgg ggtaacaaag cttacgggag 2744041 aaaagctttg ccatgtgtat aaacagagct ttggcattcc aattgtgatt ctccgttttt 2744101 ttaccgtata cgggccaaga cagcggccgg atatggcttt tcaccggctc attaagcagc 2744161 accttcagca aaagccgctt accatcttcg gtgatgggca gcagtcaaga gatttcactt 2744221 atatcagcga ctgtgtcaaa ggcatcaccg ctgttcttgg gaaaccccac cttattggtg 2744281 aaacagtaaa tatcggcggc gcagagcgtg cctcagtctt aaaagttgtc tccctcattg 2744341 aggatatttc cgggagaaaa gcaacactgc acttttcgga caaaatagca ggggaaccga 2744401 gcaacacgtg ggcggatatt tcaaaagcaa aacagctctt gcattatgat cccgccacat 2744461 ccttaaagga tggcttgacc aacgaaatcg cctatttatc gtcgctgtat cagggggaat 2744521 aaaaatgaag cttgccttta tctgtacaga aaagctgccg gcgcccgcag tacgcggcgg 2744581 cgctattcaa atgatgattg acggtgtcac gccctatttc agcagcaggt acgacctgac 2744641 cattttttca atagaagatc catcgctccc aaaaagagaa acaaaagacg gcgtacatta 2744701 tatccatctg ccaaaagaac attaccgcga ggcggtagcc gaagagctgc gagcctcttc 2744761 ctttgacctc attcatgtgt tcaacaggcc tttaaatgtc tctttatata aaaaagcctc 2744821 accaaacagc aagatcgttc tgagcctgca taacgaaatg ttttctgaaa aaaagatgac 2744881 cttcgcgcaa ggaaaagaag tactcgacaa tgtctccatg atcacaacag tgagcgaatt 2744941 tattaaacaa accgtcattg aacgtttccc tgaagccgag gacatcacaa aagttgtgta 2745001 ttccggcgtt gatttaaact cttatccgcc cgtctggacg atgaaaggct cggctgtcag 2745061 aaaaacatac cggaaaaaat acggtattga agataaaaaa gttattttat tcgccggccg 2745121 cttaagcccg acaaaagggc ctcaccttct cattcacagc atgagacgga ttttgcagca 2745181 gcaccctgat gctgtactgg tcatagcagg cgggaagtgg ttcagcgatg acagcgaaaa 2745241 ccaatatgtc acctatctgc gcacgctggc gctgccatac agagaccaca taatctttac 2745301 aaaattcatt cccgcagacg atatcccaaa cctttttctg atggcagatg tatttgtgtg 2745361 cagctctcag tggaacgaac ccctcgcccg tgtgaattat gaagcaatgg cggccggcac 2745421 gcccttaatt accacaaacc ggggcggaaa cggtgaagtc gtaaaacacg aagtcaccgg 2745481 ccttgtcatc gatagctaca acaaaccttc ttcatttgca aaagcaattg acagagcctt 2745541 tacagatcaa gaattaatga acaaaatgac aaaaaacgcc cgaaagcatg tagaagcttt 2745601 atttaccttt acccatgctg ccaaaaggct caatactgtt taccaatccg ttctgacccc 2745661 gaaaaacaaa caatttccgc cgccttttct gacgcaaaat tttgatttat catctatcaa 2745721 tcagcttttt gtgaaagcaa aaacataaaa cctacagctc gtgttgcaaa acgggctgtt 2745781 ttttcgctac agagaactta aaaaaaggca taaatgtgac tttatgcctt gcgctttaca 2745841 gtttgagaaa accatggagc tggtttagat tcacttggaa gaatgatgat ttccacttta 2745901 gcttcttccg ctaagtctgg ttcttcatct tcatcctctt cttcatatgg gggcgctgag 2745961 cgtttcgaat cacgctcctc ctcaggctcc agagtggttt cgaattttgt ttcttcttca 2746021 tcatcgacga ttttgcgatc tgtttccttt tccttcgttt ctttttgata ttctttcggt 2746081 gcattgatgt gagggagctc tcgaatgctg cccacatcta aatgcttctc ctcttcttcc 2746141 ttctcagctg agattgagtc atgagcctgc catcccatcg gtccaggcgg tgtaaatacg 2746201 aattggtcga gatccagttt agaaatagag gctttttgtc tcgatgacct catgtcaatt 2746261 cgcctcccga tacgctttta tctttttata cagttccggc agtttatcca aaaacgaatc 2746321 tttagattct tcaacagaaa tcatgttttg cagcgcccag ttatacttct catctgacca 2746381 cgttttcttt tgcttcaaat aatatttgtg cccgattgca cagaacaaat gcggaaacgc 2746441 gagatcaatc caaagtacct cgtactgttt ttctgtgagc ggatacactg cgtcgtaggc 2746501 cgcaagcagt gcaaccatga aatcagtatc ccatacagaa agcttaacca tcactttatt 2746561 cagcagaata cgaaggtctc ttgacggcaa atcgtaggta atcgagtgaa gctcctttaa 2746621 aaaaggctcc ccttcgatct cagtcaaacg tgccaatgta aaatcctgaa aacagaatcc 2746681 gccatgctcg agtgtctctt ttgtccaggt ttcgtattct gagtcatcaa gcgctctgag 2746741 agcttctttt cctcttgcca gcattttatc agcatgtttt aagaaagttt gcgaaaatac 2746801 gtcatcagga taggatgctg cgatctgcat attcccttca agttcctgca gcttccaacg 2746861 gtacaatttg tgccattttc ccagcctgct tctcttcttg ctttcatctg tgcaaacata 2746921 tccttttgag gcatgatgaa aatggccggc aaatgacatg acttttttca tttgctctgc 2746981 atcatagtaa atcatttctt ttcctgtcac tttgtcatat aaactgtaag aaacctgatc 2747041 cgtgcccaag cagctaccgc cattttttgt ttgatgaatc ggcgctatcg gcagcccttt 2747101 ctcttgtaaa tgggcgtgtg cctgagtgat aaaaagcatc cgctccggtt tcatttgcgc 2747161 ttcttttagc agctttgggc catgatcagt ttcgacttcc cagattttgc gcccgctttt 2747221 gttcgatttc agcgccacat ggtcgatatg aaacggataa taactgagaa tttcggacac 2747281 aatctgttct tcatgctctt tttggtacac tctgttcacc ccttctatct gttcttttca 2747341 tagacgctga gcagattttc agccaccctc tgccagccaa aattgctttc tgcctcacgg 2747401 cggctgtatt tcccaagccg ttcccgcttt tccgagctgc tcagcaaatc attgatacgt 2747461 tcggcatatt gtttaggatt ttcaaagtca tgaatgatgt agccgttttt cccttcctct 2747521 atgacctctg gattgcctcc ccgattgctt gtaataatag gaagtcccgc agccatcgct 2747581 tcataatgca cccttgctaa aggctcctgc cattgcgaag agcatacaaa tacatctgac 2747641 atggtataaa ggcgcggaat gtcctttggc ttcacaaatt gaataaatgt gacatgatcc 2747701 ttttgcatcg caccaagggt atgaagatgt ttgacatagt tatttaattc attatctccg 2747761 aaccattttg acccgataaa caccatcatg acatcggggt gctcctcaat gatgtccggc 2747821 aaagcctgca ataatatgtg cgggcctttg actttgctaa gccggccgac aaacaagacg 2747881 atttttttgc cgtgaagccc cagctcgctt cgcatctctt cgcgagctcg ctgcccttca 2747941 ttcgtccagc gagggtggta cgtttttaaa tccacaccag aatacaccgt ttttgttttt 2748001 gatcgtgctg acggaaaacg gcttgtgatc gtctgtccga tataatcgct gaccgtaaca 2748061 atctgcgcta cggagtcgat gcaaatctcg ccttccgcct ggctgatttt atcgtaagcg 2748121 aacatttcat tgtgaacgct taaaataaaa acagcatccg gcgcctgttt cttcaatttc 2748181 ggaacccagc ttgggcgatt acaaacatgc acaagatcaa aacggctctt tttcagctct 2748241 gctccaacgg cttcttcata acggtcttca tccaaatgca cataatggac accgtctacc 2748301 ttctctctat cagcgagatt cggatcttta atagaaaaca cagtcacctc atgttttttt 2748361 gcaattaaag gggcaaccgc ttcgaggtag atttgaatgg cgcctcctcg aaccgatggg 2748421 acaggaagct tctctgtggc gatcagtgct attttcatac atagcctcca ttcctgcatg 2748481 atttttaact agttagaatc atgatacggc tgaacaacca acttgtgcgg aatgggactg 2748541 ccctaaaaac aaaacgggta aacaaccaga ttcatctatt aaatatagtc aaataactca 2748601 atcatttttt ccttttgatt cataaggtag gagtaaaaca ggtaaggatg tgtcctttaa 2748661 tggcagaaaa ccatgaagtc attgaggagg ggaattcatc agagcttcct ttatcagcag 2748721 aagatgcaaa aaaattaacg gagctggctg aaaatgtgct tcaaggatgg gatgtgcagg 2748781 ctgaaaaaat agacgtcatt cagggaaacc agatggcgct tgtctggaag gtccacacag 2748841 actccggcgc ggtttgtcta aaacgaatac acaggccaga aaagaaagcg ttgttttcca 2748901 ttttcgcgca ggactattta gcaaaaaaag gcatgaatgt tcctggcata ctcccaaaca 2748961 aaaaaggcag cctatattct aagcacggct catttctatt tgtcgtatat gactggatcg 2749021 aaggaagacc gtttgagctg actgtaaagc aggacttgga gtttatcatg aaaggccttg 2749081 ctgattttca tacagcttcc gtcggatatc agccgccaaa tggcgttccc atatttacca 2749141 aattaggtcg ctggccgaat cactacacga aacgatgcaa acagatggaa acgtggaagc 2749201 tgatggcgga ggcggaaaaa gaagatcctt tctcacagct ttatcttcag gagatagatg 2749261 gctttattga agacgggctg cgcatcaaag accggctttt gcaatcgacc tatgttccat 2749321 ggactgaaca gctgaaaaaa agccctaacc tttgccacca ggattacgga accgggaata 2749381 cactcttagg agaaaatgaa cagatttggg tcatcgactt agataccgta tcatttgatc 2749441 tgcctattcg cgatttgcgc aaaatgatta ttccgctttt ggatacgacg ggtgtttggg 2749501 atgacgaaac atttaatgtc atgctgaacg catacgaatc cagagcccca ttaactgaag 2749561 aacaaaaaca agtcatgttt attgatatgc tgtttcctta cgagctttac gatgtcattc 2749621 gcgaaaaata cgtccgcaag tctgctttac cgaaggaaga attagaatca gcttttgaat 2749681 atgaacgcat taaagcaaac gcattgcggc agcttattta agaccatcat ttcccccgca 2749741 tatcgggggt ttgatattta taagataaag ggtaattaaa tacatgcgga ggttgcaaat 2749801 atgaaaaaga ttgtcggcgc tttagccgtt tttgtgatta catatgcgct gttttcagcc 2749861 gcaggctacc tgtttcctgt ggaccaagaa tggtacaatt cattgaaaaa accggactgg 2749921 acgccaagcg gaactgcgat cggcatcatt tgggccatcc tgtttgccct gatctccctt 2749981 tcagcagcca ttgtatatgc tgcgttttca tttaaaggtg cgaaaagctt ttggtttaca 2750041 cttttgataa attacgtgct caatcaagcc ttcagctatt tccagtttac gcaaaaaaat 2750101 ctgctggctg catcgcttga ctgcctgctt gtcgccatca cagcaatcgt attactgatc 2750161 attgccaaaa aatacagcag agccgcaagc tatcttcttt tgccttattt tttatggagt 2750221 gcatttgcga cgttcttatc ctttacaatc aattcaatga atctgtgaac aaaaaaagcc 2750281 gcttatacag cggctttttc acatcatcgg cttgatgccc caaatgtcct tcgcatattc 2750341 ccggatcgtg cggtcgctgg agaaatatcc agaatgagca atgtttacaa tcgaatgctc 2750401 agaccatttc cttcgctctc gataatcagc ttgaattcgc tcctgtgcat ctgcatatga 2750461 gctgaaatcc ttcagcacaa aatactcatc attatgcgga agcagcgagt caaagatcga 2750521 ttcaaattca tctgcctctc cttcaaaaaa accattgatc aactgatccg ctacctgcct 2750581 gattctcctg tcatgctgat aatattccct cgacctatag ccgccgtttt cctgatacga 2750641 tagaacctca tccgccttta agccgaacgt gtaaatacag tcagggccca cccgctcaag 2750701 gatctcgata tttgcgccgt catgcgtgcc gatcgtcaaa gccccgttca tcataaactt 2750761 catattccct gtaccagacg cttccttgct tgcggttgaa atttgctcac ttacgtctga 2750821 tgccggaaaa attcgctcag ccatagaaac tctataattt tctaaaaaaa caactttgat 2750881 cagctgtttg accgccggat cataattgac tttttctgcg acagaatgga tcagcttaat 2750941 gattttcttg gcataataat agcttggtga agcctttgcc ccgaaaataa aggtttgcgg 2751001 gtagattgaa aaccccgaat cctccttgag gcggttatac aaatacataa tgtgaagaac 2751061 attcagcagc tgccgtttat atgcatgaag ccgtttcacc tgtacgtcga atatgctctc 2751121 agggttcaca accaccccgg ccgtgcaaaa aatcaaatcg gcaagctctt gttttttctt 2751181 gcttttgttg ttttgaaact gttcaataaa tgcaggatca gtggcgtacg gttctaaacg 2751241 gatcagtgat tccggctgct tgacccattc atcgccgatc gcctctgtaa tgatggcaga 2751301 caagcctgga ttcgctttta acagccagcg cctgtgggca attccattcg tcttattgtt 2751361 aaaacgattc ggaaacagca agtgaaagtc gcgcatctcc ctttccttta atatatcgga 2751421 atgtattttt gcaacgccat ttacactgta gctgcctact atggccagat gagccatttt 2751481 gacaacacca tgcgctgtaa tcgccatgtt ctctatcctt ttccagtctc caggatactt 2751541 ttcccaaact gcacggcaaa acctctcatt gatctcttca ataatcatgt acattcgcgg 2751601 gagcagcggc ttaaacaaat gaatcggcca tttctcgagc gcttctgaca atgttgtatg 2751661 atttgtataa gaaatcgtat gtacagtgat atgccaagct tcttcccagc tcatgttctc 2751721 ttcatcgagc aaaatccgca ttagctcagg caccgcaagc gcagggtgag tgtcattaat 2751781 atgaatgctc acttttttat gcaggccgga taaagattta tgtgttttac ggtaattgtt 2751841 cacaatgctt tttaagcttg cgcatactaa aaaatactgc tgcttcagcc gtaaaatttt 2751901 cccctcatca tgggtgtcat cgggatataa gaattcagaa accgcttctg tttctcgctt 2751961 ataagacaaa atattaccgc cgtgataatg ggcatagggc tcggcgttcc aaagccttaa 2752021 cgtgttgaca gtgcccgttt catagccgat gatcgggata tcataaggaa cagcggtaac 2752081 aattgtcgct tgttcatggc gaaaatgcag gcgcccgctt ttttctgtca tatggacttc 2752141 gccccaaaac ggcacgtcca ctgcttgatc cgcattcctt acttcccata cgttcccgtt 2752201 tttcagccat tgctcaggca gctccacctg atgtccgtct acaatttttt gctcaaacaa 2752261 accatgctta taacgtatgc ccatgccgtg cccaggcagg ttcaacgaag caagcgaatc 2752321 taaaaagcaa gcggccaagc gcccaagtcc gccattgccg agacctgcat cgttctctat 2752381 ctgaaggatc tcctctaaat tgatgccgat ttcctttaaa ccagcttcta caacatcacg 2752441 aacaccaaga ttcattaagt tttgctcaag gagctgaccg agcagaaatt cgattgataa 2752501 ataatatgtc tgcttcccgg aatttgatct gcttttttca ttcgtttcga tccaatcagc 2752561 gctgatatac tctctgacca tattgcccaa cgttttatat tgatccagct tggcagaatc 2752621 tttaaagctt tttccgcacg tcatttccag acgctttaaa aataagtctg caaagcgttc 2752681 tttactcgag aacatcccgt ccactccttg tcacctgctc gaaaatacgc tgatactctt 2752741 tagccgactt cccccagctg taatctgcat tcatagcggt cttcacgatg ctcttccata 2752801 catcctgttg gcaataaaac gacagcgccc tttctatcgt aaatttcaga tcatgcgcat 2752861 taaaggcgga aaacgtaaag ccattgcccg ttccctcttc ctcctgatag gcacggacag 2752921 tgtcgtaaag accgcccgtt tccctgacaa tcggaatggc gccatattga agagcaatga 2752981 gctgccccaa accgcacggc tcaaatttcg acggcatcaa aaacatatca gagcccgcat 2753041 aaatttgatg ggctagcggc tcatcaaacc cgatataagc ccggcacttc tcatgaaaag 2753101 caaattctgc ataccggaaa taatcttcaa attcacgttc tcctgtgcct agcacaacca 2753161 gctgtatgtc ttgctcctca agaagttcgt gcataattct gcggacaaga tcaagcccct 2753221 tttgtttagt gagccttgtc accatactga tcagcggaat atcgtttttc tctggaagcc 2753281 ccatccgctg ctgaagcttc gttttgtttt ccagcttgca tgcaagatcc cctgaatcgt 2753341 attgcgcctc tatataaggg tcgcttttcg gctgatagaa cgtatcatca atgccattta 2753401 atatgccggt tacatcatct tccctatatt gcaaaacctg ttccaactgc tcaccataat 2753461 acggcgtcat gatttcattt ctgtaagtgg ggctcacagt tgtcacatga tcagccgcaa 2753521 tgatgcccgc tttcataaaa ttaacaaatc cgttgcattc taacctttca taatgaaaat 2753581 gatccatctc aagacccagc aagtcatgtg tgacatcagg agggaatatg ccttgaaact 2753641 gcaggttgtg gatcgtgagc acgcttttca tccgttcata aaaaggatgt tttctgtact 2753701 cctctttcag caaataattg accatcgctg tatgccaatc gtgagtatga acaatatcgg 2753761 cttgaacatt cacaactttg gcagcctcca gcacagctct tgaaaaaaag gcaaaccgct 2753821 caccgtcatc ataatgcccg tacaacgaat ccctgttgaa atagtactca ttgtcgatga 2753881 agtaataatt cacatcattc tctgccatat gttcaattcc gcaatattgc tgccgccagc 2753941 cgacagctac ggtacactca gcctgttttt tcatacgctt tttccacggt tcaggtattt 2754001 ggctgtactt cggcagcatc acagctacct cattgcctaa tcgcgcaagc gcctttggca 2754061 gagcacctgc tacatcggca agacctcctg atttcacaaa tggggtgcat tctgacacag 2754121 caaataatat cttcaagaat tcatcagctc tccttgcacc aaaccttttc ttaatacaag 2754181 cggctgctca gctgttcctg cagcttccgt cgccttgccg attttaacat ccttatccga 2754241 aatgacctgc tcaagaagac aatcctctcc aatctgcgtt ttttgcataa taatgcagtt 2754301 tttcagcttc gtaccctttc cgacatggac cgccctgaac aaaatgcagt tttcaacctc 2754361 tccttcaagc acacagccgt ttgccaccaa agaatttttg acagtgctgt gctttccgta 2754421 tttcgtaggc ggctcatcct tcacttttgt atagatcggc tgctgcggca aaaacacctg 2754481 ctgccaaaaa cgaggctgaa tgagctccat actgtgggta taatattttt ccaccgaatc 2754541 aatgacagcg gcataacctg aatattcata agggcaaatg gtcagggcgg aagattcctt 2754601 ttcaacagcc tcctgaatgg ttttatagcc tttttcgcta tgtccgtaga tcagatcctt 2754661 taaaagcgtt gttgacatga tatagatttg cagcgactgg ccgtcctgaa atacctcggt 2754721 gacgtcgcag ccaacctcct gatggcgttt cagcacatat tgaaattgaa tgttgcatac 2754781 ggtatggctg ttggagatta cagcatattg ctgagtgctt ctgtggaagt aatctagatg 2754841 gtccgaaaac tggcgaaagg aaccgaattc atcgtattcg tgatgaagat ggggagacgg 2754901 gaaaaaaaag aggccgtcct ttttccggtg caaatcccat tccttacccg ccccaaggtg 2754961 atccatgagc gaacggtaac gatacttcgg aaaaattgca acactcctaa tatccgcatt 2755021 caccatgttg gaaagcataa aatcaatcag tcggtacctg ccggcaaaag ggatcgcccc 2755081 gagcgaccgc tgtgctgtta aatcctgaag agaatgctta tatgtggttt catctataac 2755141 acctaacatt tgattattga acactgactc tgccccctct tcagtaatta aatcaattct 2755201 ttttctacaa attcctctga aacgagcagc acctcttcaa tgtctttttc ggagcgaatc 2755261 actgcgccat ccggcagcac catcccatta ggaacgatgg cattttcaat gactacatgc 2755321 tccccaatcg tcacatccgg cattatgacg gatgatgtaa cagtcgtatg cttaccaaca 2755381 gtcacacctt gaaaaagaac ggagtgagac acatttccat atacaacaca accttcgttc 2755441 acaagcgaat cttgaacctg cgcatcagat gaaataaatt gcggaggctg atttggattg 2755501 acggagtaaa ttttccattt gcgttcaaac agcttcagct ccgagtcctc ttttaacaaa 2755561 tccatattgg cttcccacaa gctctgcacc gttccgacat ccttccaata tcccttgaac 2755621 ggataagcag aaagcttctt tttctcttcc aaaagcagtg gaataatgtc tttgccgaag 2755681 tcgtggctag aataagggtt ttgatcgtcc atctcaagat actgtttcaa aagcggccaa 2755741 ttgaatatat aaattcccat tgaggcaaga ttgctcttag ggaatttggg cttttcatca 2755801 aaatgtgtga tcgtcccatc tggattggcc ttcatgatgc cgaaccggct tgcttcctcc 2755861 cagcccactt cgatgacaga gatggtcaca tctgctttct tttcaatgtg ataatcaagc 2755921 attttgccgt agtccatttt gtatatgtga tctcctgata aaatcagtac atactcagga 2755981 tcatactgat tcaaataatt gagattttca taaatggagc ttgccgtccc tttataccat 2756041 ttgacttctg atgactcggc ataagggggt aaaaccgtca cgccgccatt atatctatcc 2756101 aggtcccatg cactgccgat cccaatatag gaattcagct cgagcggctg atattgcgtt 2756161 aaaatcccga ctgtgtctat gcctgaatta gaacagttgc ttagggtaaa atcaataatc 2756221 ctgtattttc ccccgaaaga tacagccggt ttggccatat tttttgttaa tccgctgaga 2756281 cggctgccct tcccgccggc aaggagcatg gctacacatt gttttttcat ctttttatct 2756341 ctcctctttt tttaaccgcc cgtaaaatcg agatgccgta aggggggatg gtcatcgtga 2756401 tataacacgg tttatgatga agtgctccct ttttagccga taacggcttt ttgttgattt 2756461 gccctgagcc tccatatgtt tcactgtcac tgttaagcac ttcaatgtat tgagtaaaaa 2756521 aaggaactcc aacatcatat tgatgataga ccacgggtgt aaaattacaa atgatgacaa 2756581 gcgcctcacc gtgcttttgg ccataacgaa taaaagaaaa gattgattgt tcgtcattat 2756641 ggacatcaat ccattcaaac gattgtgcac gatggtcatg ctcataaagg attttgcttt 2756701 tttggtaaaa gcggagaaga tcttgcgtaa aaacgctggc tttctgatgc atggggaagg 2756761 agtccaaaaa ccaatcaagc tgttctgtat ctttccattc atcaaattga gcaaactctg 2756821 atcccataaa gatcaatttc tttccgggat gcactgtcat atagcccagc aaaagccgat 2756881 actgggcaaa tttctgccag tagtcgccag gcattttatt gagaagtgat ttttttccgt 2756941 atacgacttc atcatgagaa aacggcaata caaaatgttc actaaacgca tatagtaatg 2757001 aaaaagagat aagctgatga caatgccgcc tttcttcggg cggcgtctcc atgtatttca 2757061 gtacgtcatt catccatccc atattccatt tataatgaaa accaagcccc ccttcctcaa 2757121 cggcacctgt cacttgaggc cattctgtag aatcttctgc aatcatcatc acatggggat 2757181 atgcctctct catggtttga ttgagttttt ttaaaaaatc aacagcatat ggattcgtgt 2757241 ggcgttcatc ctgatttggc caatacaaga tattagccac tgcatcaacc ctaaatccat 2757301 ctatatgata gaattccgcc cagtacaacg cattcgaaat taaaaaacta tgaacttccg 2757361 gtttccccag gtcaaagttt gccgtgcccc ataaccagtt ctcccgatca cgttcttctt 2757421 tgtattcata aagcggttct ccatcaaaca tataaaggcc atgtgcatct ttacaaaaat 2757481 gtccggggac ccaatccaaa atgactccga tattttgttg atgacattca tccacaaact 2757541 tcatcagatc atgcggcggg ccaaacctgc ttgtcgggct gtaatacccc gttccttggt 2757601 acccccatga acgatcatat ggatgctcat acacgggaag cagttcaata tgggtaaacc 2757661 catgcttctt gatataaggg ataagcgtct gacttaattc tttataggaa taatgcctgc 2757721 catcagaatg cttcttccaa gacccaagat gcagttcata aatgaaaaca ggtttttcat 2757781 acagcgtctt agccttctgt ttcttttgcc atttttgatc ttgccagctg tatccttcca 2757841 aatcgtaagt aagtgacgct gtgtttggtc tgacttctga ataaatagcg tatggatctg 2757901 ccttcagcct gatctcaccg ttattcgtca caatttcgta tttatatcgt tccttttctc 2757961 ctatacctgg aataaataac gtccaaatgc cattatcatt cactctgtgc atcacatgct 2758021 cttctccaga ccagctgtta aaatctccag ccactcgtac ttccgacgca tgaggcgccc 2758081 acacacagaa ttcatatccg cttttgccat tcagctcgcg gtaatgcgag ccaaacagct 2758141 gatagctttt aaacagactg ccttcgtgaa aaagataaac atcatgtgct gtcgggctgg 2758201 cagcggccat gtaatcatcc tttctgacat catagttttc atttatagta tttattcgaa 2758261 gaaataaaaa aaagcccttt cctgaaagcg cttatactta tagacaatta acttcatttt 2758321 ctgaagaaaa acgaaatata tggagatttt tgtagtctgt ttttaaaata aagaacaaaa 2758381 tctaagacat atcatgattt ataaaaacaa aaaaaccttg caggatatgc aaggcttctg 2758441 gatgacccgt acgggattcg aacccgtgtt accgccgtga aagggcggtg tcttaaccgc 2758501 ttgaccaacg ggccgataat tatgatatct gtaatcatat ggcggagaag gagggatttg 2758561 aaccctcgcg ccgcttacac gacctacacc cttagcaggg gcgcctcttc agccacttga 2758621 gtacttctcc atttggctcc acaggcagga ttcgaacctg cgaccgatcg gttaacagcc 2758681 gatagctcta ccactgagct actgtggaac aaaagtcatg gtgggcctga atggactcga 2758741 accatcgacc tcacgcttat caggcgtgcg ctctaaccag ctgagctaca ggcccatgac 2758801 gatatagaaa tggagcgggt gatgggaatc gaacccacga catcagcttg gaaggctgag 2758861 gttttaccac taaactacac ccgcaatttt tatttggggc gattgatggg aatcgaaccc 2758921 acgaatgcca gagccacaat ctggtgcgtt aaccacttcg ccacaaccgc caaagcatat 2758981 tgataaatgg tggctcggga cggaatcgaa ccgccgacac acggattttc agtccgttgc 2759041 tctaccaact gagctaccga gcctaagtat ttaaatggcg gtccggacgg gactcgaacc 2759101 cgcgacctcc tgcgtgacag gcaggcattc taaccaactg aactaccgga ccattttaaa 2759161 atttggttgc gggggcagga tttgaacctg cgaccttcgg gttatgagcc cgacgagcta 2759221 ccgaactgct ccaccccgcg atgattagga atatgtatgg cggaggaaga gggattcgaa 2759281 cccccgcggg ctttgacacc cctgtcggtt ttcaagaccg atcccttcag ccagacttgg 2759341 gtattcctcc gtatagtggt ggaccttgta ggactcgaac ctacgaccgg acggttatga 2759401 gccgtctgct ctaaccaact gagctaaagg tccattggta gcggcggagg ggatcgaacc 2759461 cccgacctca cgggtatgaa ccgtacgctc tagccagctg agctacaccg ccaaatattt 2759521 ttgaaatcaa gtggagccta gcgggatcga accgctgacc tcctgcgtgc aaagcaggcg 2759581 ctctcccagc tgagctaagg ccccaagaat ggtcgggaag acaggattcg aacctgcgac 2759641 cccatggtcc caaaccatgt gctctaccaa gctgagctac ttcccgattt catatagatc 2759701 atggcgcgcc cgagaggagt cgaaccccta accttttgat ccgtagtcaa acgctctatc 2759761 caattgagct acgggcgcaa aacttaatgc cgagggccgg acttgaaccg gcacggtagt 2759821 cacctaccgc aggattttaa gtcctgtgtg tctgccaatt ccaccacccc ggcgtggatg 2759881 gtatagttgg agcggaagac gggattcgaa cccgcgaccc ccaccttggc aaggtggtgt 2759941 tctaccactg aactacttcc gcagaaatgg tgcggatgaa gggacttgaa cccccacgtc 2760001 tgtaaagaca ctagagcctg attctagcgc gtctgccaat tccgccacat ccgcaacatg 2760061 taaatggtga gccatgaagg actcgaacct tcgaccctct gattaaaagt cagatgctct 2760121 accaactgag ctaatggctc ttcttacaat agacttgaat attatatcat ataaaagtgg 2760181 tgccggcaag aggacttgaa cccccaacct actgattaca agtcagttgc tctaccaatt 2760241 gagctacacc ggcatatatg taaaaccgat atgtataatg aaaaatggtg gaggatgacg 2760301 ggctcgaacc gccgaccctc tgcttgtaag gcagatgctc tcccagctga gctaatcctc 2760361 catacttgca ctaacgtgca attgcttggc ggcgtcctac tctcacaggg ggaaaccccc 2760421 gactaccatc ggcgctgaag agcttaactt ccgtgttcgg tatgggaacg ggtgtgacct 2760481 cttcgctatc gccaccaaac aaattgagag tgttctctca aaactagata acaggtgtga 2760541 catcattcaa aaatatggtt aagtcctcga tcgattagta tctgtcagct ccatgtgttg 2760601 ccacacttcc acctcagacc tatcaacctg atcatctttc agggatctta cttccttgcg 2760661 gaatgggaaa tctcatcttg aggggggctt catgcttaga tgctttcagc acttatcccg 2760721 tccgcacata gctacccagc gatgcccttg gcagaacaac tggtacacca gcggtgcgtc 2760781 catcccggtc ctctcgtact aaggacagct cctctcaaat ttcctgcgcc cgcgacggat 2760841 agggaccgaa ctgtctcacg acgttctgaa cccagctcgc gtaccgcttt aatgggcgaa 2760901 cagcccaacc cttgggaccg actacagccc caggatgcga tgagccgaca tcgaggtgcc 2760961 aaacctcccc gtcgatgtgg actcttgggg gagataagcc tgttatcccc ggggtagctt 2761021 ttatccgttg agcgatggcc cttccatgcg gaaccaccgg atcactaagc ccgactttcg 2761081 tccctgctcg acttgtaggt ctcgcagtca agctcccttg tgcctttaca ctctgcgaat 2761141 gatttccaac cattctgagg gaacctttgg gcgcctccgt taccttttag gaggcgaccg 2761201 ccccagtcaa actgcccacc tgacactgtc tccccgcccg ataagggcgg cgggttagaa 2761261 ggtcaataca gccagggtag tatcccaccg atgcctccac cgaagctggc gctccggttt 2761321 ccaaggctcc tacctatcct gtacaagctg taccaacatt caatatcagg ctgcagtaaa 2761381 gctccacggg gtctttccgt cctgtcgcgg gtaacctgca tcttcacagg tactataatt 2761441 tcaccgagtc tctcgttgag acagtgccca gatcgttgcg cctttcgtgc gggtcggaac 2761501 ttacccgaca aggaatttcg ctaccttagg accgttatag ttacggccgc cgtttactgg 2761561 ggcttcaatt cgcaccttcg cttacgctaa gcgctcctct taaccttcca gcaccgggca 2761621 ggcgtcagcc cctatacttc gccttacggc ttcgcagaga cctgtgtttt tgctaaacag 2761681 tcgcctgggc ctattcactg cggctctctc gggcttgcac cctaacagag caccccttct 2761741 cccgaagtta cggggtcatt ttgccgagtt ccttaacgag agttctctcg atcaccttag 2761801 gattctctcc tcgcctacct gtgtcggttt gcggtacggg cacctctcac ctcgctagag 2761861 gcttttcttg gcagtgtgga atcaggaact tcgctactat atttcgctcg ccatcacagc 2761921 tcagccttat gggaaacgga tttgcctatt tcccagccta actgcttgga cgcggatatc 2761981 caataccgcg cttaccctat cctcctgcgt ccccccattg ctcaaatggt gaggaggtgg 2762041 tacaggaata tcaacctgtt gtccatcgcc tacgcctttc ggcctcggct taggtcccga 2762101 ctaaccctga gcggacgagc cttcctcagg aaaccttagg cattcggtgg aggggattct 2762161 cacccctctt tcgctactca taccggcatt ctcacttcta agcgctccac cagtccttcc 2762221 ggtctggctt cacagccctt agaacgctct cctaccactg ttcgaagaac agtccgcagc 2762281 ttcggtgata cgtttagccc cggtacattt tcggcgcaga gtcactcgac cagtgagcta 2762341 ttacgcactc tttaaatggt ggctgcttct aagccaacat cctggttgtc taagcaactc 2762401 cacatccttt tccacttaac gtatactttg ggaccttagc tggcggtctg ggctgtttcc 2762461 ctttcgacta cggatcttat cactcgcagt ctgactccca aggataagtc attggcattc 2762521 ggagtttgac tgaattcggt aacccggtag gggcccctag tccaatcagt gctctacctc 2762581 caagactctt accttgaggc tagccctaaa gctatttcgg agagaaccag ctatctccag 2762641 gttcgattgg catttcaccc ctacccacac ctcatccccg cacttttcaa cgtgcgtggg 2762701 ttcgggcctc cattcagtgt tacctgaact tcaccctgga catgggtaga tcacctggtt 2762761 tcgggtctac gaccacgtac tcatgcgccc tattcagact cgctttcgct gcggctccgc 2762821 atcttctgct taaccttgca cgggatcgta actcgccggt tcattctaca aaaggcacgc 2762881 catcacccgt taacgggctc tgactacttg taggcacacg gtttcaggat ctctttcact 2762941 ccccttccgg ggtgcttttc acctttccct cacggtactg gttcactatc ggtcactagg 2763001 gagtatttag ccttgggaga tggtcctccc ggattccgac ggaatttcac gtgttccgcc 2763061 gtactcagga tccactcagg agagaacgaa gttttgacta cagggctgtt acctcctatg 2763121 gcgggccttt ccagacctct tcatctacct cgttcttttg taactccgta cagagtgtcc 2763181 tacaacccca agaggcaagc ctcttggttt gggctgatcc cgtttcgctc gccgctactc 2763241 agggaatcgc atttgctttc tcttcctccg ggtacttaga tgtttcagtt ccccgggtct 2763301 gccttctcat atcctatgaa ttcagatatg gataccactc cattacgagt ggtgggtttc 2763361 cccattcgga aatctccgga tcaaagcttg cttacagctc cccgaagcat atcggtgttc 2763421 gtcccgtcct tcatcggctc ctagtgccaa ggcatccacc gtgcgccctt tctaacttaa 2763481 ccgttaaaaa gaatcactat gtgatatctt gtgttactaa ttgaatgtga tgtctactgt 2763541 tatctagttt tcaaagaaca cgtttcgaag gaatgatcct tcaaaactaa acaagacagg 2763601 gaacgttctg tttataagac cttgggtctt atattccgta taatatcctt agaaaggagg 2763661 tgatccagcc gcaccttccg atacggctac cttgttacga cttcacccca atcatctgtc 2763721 ccaccttcgg cggctggctc ctaaaaggtt acctcaccga cttcgggtgt tacaaactct 2763781 cgtggtgtga cgggcggtgt gtacaaggcc cgggaacgta ttcaccgcgg catgctgatc 2763841 cgcgattact agcgattcca gcttcacgca gtcgagttgc agactgcgat ccgaactgag 2763901 aacagatttg tgggattggc ttaacctcgc ggtttcgctg ccctttgttc tgtccattgt 2763961 agcacgtgtg tagcccaggt cataaggggc atgatgattt gacgtcatcc ccaccttcct 2764021 ccggtttgtc accggcagtc accttagagt gcccaactga atgctggcaa ctaagatcaa 2764081 gggttgcgct cgttgcggga cttaacccaa catctcacga cacgagctga cgacaaccat 2764141 gcaccacctg tcactctgcc cccgaagggg acgtcctatc tctaggattg tcagaggatg 2764201 tcaagacctg gtaaggttct tcgcgttgct tcgaattaaa ccacatgctc caccgcttgt 2764261 gcgggccccc gtcaattcct ttgagtttca gtcttgcgac cgtactcccc aggcggagtg 2764321 cttaatgcgt tagctgcagc actaaggggc ggaaaccccc taacacttag cactcatcgt 2764381 ttacggcgtg gactaccagg gtatctaatc ctgttcgctc cccacgcttt cgctcctcag 2764441 cgtcagttac agaccagaga gtcgccttcg ccactggtgt tcctccacat ctctacgcat 2764501 ttcaccgcta cacgtggaat tccactctcc tcttctgcac tcaagttccc cagtttccaa 2764561 tgaccctccc cggttgagcc gggggctttc acatcagact taagaaaccg cctgcgagcc 2764621 ctttacgccc aataattccg gaaaacgctt gccacctacg tattaccgcg gctgctggca 2764681 cgtagttagc cgtggctttc tggttaggta ccgtcaaggt accgccctgt tcgaacggta 2764741 cttgttcttc cctaacaaca gagctttacg atccgaaaac cttcatcact cacgcggcgt 2764801 tgctccgtca gactttcgtc cattgcggaa gattccctac tgctgcctcc cgtaggagtc 2764861 tgggccgtgt ctcagtccca gtgtggccga tcaccctctc aggtcggcta cgcatcgttg 2764921 ccttggtgag ccgttacctc accaactagc taatgcgccg cgggtccatc tgtaagtggt 2764981 agccgaagcc accttttatg tttgaaccat gcggttcaaa caaccatccg gtattagccc 2765041 cggtttcccg gagttatccc agtcttacag gcaggttacc cacgtgttac tcacccgtcc 2765101 gccgctaaca tcagggagca agctcccacc tgtccgctcg acttgcatgt attaggcacg 2765161 ccgccagcgt tcgtcctgag ccaggatcaa actctccgat aaatggatca caggttaagt 2765221 tcaccgcatc ctgcggcgac acctgtgtga cctgcgtcgt gcaggcccta gtttgactga 2765281 ctacgcacat cgcagtgcga tttttaaaaa ctgaattaac aggtacgttt tgtcttgttt 2765341 agttttcaaa gatcatttcg ttacttctca atgaagcagc tttactaata taacattcag 2765401 cttctttttt gtcaacaact tttttcaagt tgttttgaag catctagttt gtgtccgctg 2765461 tgcatcagcg acgtttaata atataacacc tgtatttatt tattgcaata gttttttaaa 2765521 aaaaatctat aaaacaaata aactataatc ctcgccatga tttctaaagc gtgtgtatca 2765581 tataagtttc ttaaaagaac atatacatca gtcatgtgat cttgttgttt ttttcgtttt 2765641 cttgtatagt agaaacgaac taaatactga tgaccacaag gggagcatta aagctgagag 2765701 tgagcggttt cgttctgacc ctttgaacct gttagttaac gctggcgtag ggatgtggca 2765761 aagtcaaatg aattgcagat cgtaaagcag tgcgtggaac ttttctcatc cttccgcgtg 2765821 ctgctttttt gttgtccttt tggttgtctg tcaatggaag gagatagata tgaatcaatc 2765881 taagcaactg gttcgcctta ttgaaattgc cattatgaca gcggcagccg ttattttaga 2765941 cattgtctca ggaatgtttc ttagcatgcc tcaaggaggc tcggtctcca tcatgatgat 2766001 tccgatcttt ttaatttcgt ttcgctgggg tgtcaaagca ggtcttacta caggtttgtt 2766061 gacaggtcta gtacaaatag caatcggaaa cttgtttgct caacatcctg tacagctatt 2766121 gttagattac attgtcgctt tcgcagcaat cggcataagc ggctgtttcg cttcttctgt 2766181 ccgtaaagcc gctgtatcaa aaacaaaagg gaaattgatt gtttcagtgg tcagcgcagt 2766241 ttttatcggc agtttgctgc gctatgccgc gcatgtcatt tcaggagctg tgtttttcgg 2766301 cagctttgct ccaaaaggaa caccggtatg gatttattct ttaacttata atgcgactta 2766361 catggttcct tcattcatta tttgtgcaat tgtcctatgt ttattattta tgacagcacc 2766421 ccgtctgctt aaaagtgaca aagcgtaaaa gtaacaatcc cccagcgaat tccgctgggg 2766481 gatttttcgt tatctgttaa gaagtgtttt taaagctgaa agatccggcc agccaagacc 2766541 tacttctttc agccttactc cggcaatttc aaagttgtcc tccgctactc tttcaggtga 2766601 ataggcctga taaaatataa tcgagggatt ctgctcaata acccaaacaa acatacttga 2766661 aaaaccatgt tgaagcaaaa actccgctcc ttttgctaag agcgccctgc ctgcaccttg 2766721 ccgctggcgc tcttccagaa gataaatagc gtataactcg ccgtcatagc cttcttgttc 2766781 agagcgaata ggtccaaatg aagcaaagcc gaatactgaa cccttttcgt cctgagcaac 2766841 aaatactccc tttaacgagc gacttttcca tttgtcttca aattccttat agttcaggct 2766901 gtttaaataa tcaatcggga taatttcgtg gtatgttgtc ctccagctgt ctacatgcac 2766961 ttttgcaatg tcctttatat cctctaactt cgcttcacgt acagttacca tacggttctg 2767021 ccctttcctt actctgattt ttggatcgtt ttggcttctt tgatttcatt tgttaattca 2767081 ttaatgcttt gttttacgtt tccttttcct gaaaagttct caagcatttc ttttacatca 2767141 attcctgagg atgcttttaa actttcttgc agacttgaca ttaagttcgt cgcatagctg 2767201 gttactttgt ttgctccgct tgattcaccg cttcctcctg tatcgacaac ggtgatttta 2767261 tcaatatttg aaagaggtgc cgctgcttgt ttcgcgtatt ccggaagcat tttgacaatc 2767321 atatcgaaaa tcgccgcctg cccgtactgt tcaaaggcgg ccgcaatttt ctcttttgct 2767381 tccgcttctg caagaccttt caggcggata acctctgctt ctgtctctcc tttcgctttt 2767441 tccgcttctg cttttgctag cccgtcaatt cttacttttt ccgcctcagc ctttgccatt 2767501 gcttcaatac tgtacttctt ggcatcggct tccgcgagct gtttggcttt ctcagctgct 2767561 gcggactgct caacagaata acggtctgca tcggcttttt tctttacctc tgagtcgtat 2767621 tgacgttcac ggcgaagaat ttctttttct tctagttcta tttgtttttg gcgttcgata 2767681 attttaacct gcatttcctg ctctgtgact tgctggcgcg ctcgggcagt ctctaaatca 2767741 tatgcttggt cggcattcgc ttttgccgta tcttgttctc tgcggaattc agccattttg 2767801 agctgattga ttttttcagc ttcagcgatt tccgtcgccc gttcaagttc tgattttttt 2767861 gcgtctttat cggcttctgc ccgcttaatt cgggtttctt tatcagcctc tgctgttgcg 2767921 atatcagcat cgcgttttac ttgggcaatt ctcggtttcc ctaatgattc aagataaccg 2767981 tttttatcac gaacatcttt aatggtaaac gagacgatta caagtcccat tttcgcgaga 2768041 tcctgtgaag cgacacgctg cacctcttga gagaattttt ctctgttttt atagatttct 2768101 tctactgtca ttgagccgag aatggaacga aggtggcctt ctaaaacctc ccgcgcttcc 2768161 tgctcacggt cgtcttttga tttccctaaa aattgttcgg ccgctgtagc gatttctcct 2768221 atagaaccgc cgattttaat aatcgcagtt ccatcggcca ttactggcac tccttgttct 2768281 gtatagactt caggtgtcga aacatcgagt ttgcttgata ataggcttag cggctctgcc 2768341 tgctggaaga cgggaaggac aaaggttcct ccgccgcgga cgattttaat acggttgccg 2768401 ccttcatcga catgaacatt tttattaccc agatagctcc ctgttacaat taacgcttca 2768461 tcaggccctg ctgtacgata cttcgtaata aacacagcta ttagtgcaat taataaaaag 2768521 aatacaactc cgatgatcat tataatcggc attgtcatat caaattcctc cttttatgtt 2768581 aaatgggttc atgcggagta accgaaagaa ctccgttgtt aatatctacg actaacaccg 2768641 ttgtcccgta actgatctgc tgattatcaa aactgaccgc tgactttgaa atggtcccgc 2768701 ctatcccttc tatgaccact tcaccaaacc cgtcaaccgg cacagctgta atcactttac 2768761 cgagtcttcc tctgagatca tcttctctat atgccaatga ttcttctgca gatgataatg 2768821 gcaccagtac aaagatgtga agcaatacca ccagcatgat cgaaaggatg caagataaaa 2768881 gcgcaatcag caagcttgac agaggcaata caagttcacc tatatatccg cccgctgaaa 2768941 aacatgtaaa aaatgagagc actaatgtcg gattaagaaa cggaatgcct tctgacagcc 2769001 ctgaaaatac atctccgaaa aacaggaata acagcgtaag gctgcccgca ataataagcg 2769061 tataaagata cattgtttgt ataggtactc caaataactc caacttcctc atcctttctt 2769121 catcaatgca ttgatgaacg gctgccgtta ccatttatac gagacacctc gggaaaagtt 2769181 tcaaaatttt aagacaaata acccatttga agtgctttat aaatgataat tgcttatata 2769241 tatggtaatg tcattttagg aggagatatg atgagtatct ttaatgaagc cagattagaa 2769301 acgtggaacg aattgaaagg actttctgac gaaaagctga atcaaaagcc ttctgctgaa 2769361 gaatggagca tacgggaagt tcttgaccat ttgaaaaaaa tcgatatgac cgcacaaaaa 2769421 atgttgaagg aacgtgtaaa ggacgctccg attaaagaaa ttgaagaaaa accgcttgaa 2769481 gtagcacagg acagaaataa taaacggaaa gccccgagtc atcttgagcc tgcgcatgat 2769541 tttatttcag gcagccaaat gaaacgtgag cttgatgtgg taagagagca gctgactgct 2769601 gcgattgcct ctctgaaaga agaagatttt gaaagagtgc ttccgcatcc tgtgtttcaa 2769661 gagctgactg tcagacagtg gatcgatttt atcggccatc atgaaaaacg gcacctcagc 2769721 caaatgaaag aaattaaaga aaagatagaa agggcctgat ttaatcagac cctttctgct 2769781 tttcgtttga cttttcgctg ataggaatga acttctattt catcacctgt gtaaacagca 2769841 ccaggtctct ccacaataca gacaatccct ctaatgccca gtgcgtggcg gacgaaagcc 2769901 gacgccagct tcggttggtc cggataataa gactgaatga cttctcccgg ctggatacac 2769961 ggatcatttt cgccctcaca cagcagagcc gctccgctcg gaaaaataat ccggcttcct 2770021 tcttttaatg aagtaagatc tggcataccg ctgactgcca cattcgcccc gagccattcc 2770081 ggcaaaattc tcggcactcc catttttaaa gcgatttcgt tgcattcctc tattgaaaca 2770141 attgaaattt gtctgcggtt gaaaatttca gtccctcttg aaaacattgg ttctctggct 2770201 cccgcttttt tggtcaggcc aaaatgcaag tcgccgggga tgccgccata atcaaaatca 2770261 agcttgtcca tttgctttgt tacgaagctt tttgtatctg cgatatataa gccttccgct 2770321 tttgcagtca tacgcttcca catcagctgg caccttcctt cttatctaaa atttccacct 2770381 atgcttcatt atcccaaaaa atcccgctct gtaaaggagc gggattttga ttataccgtt 2770441 ttaggcgtaa ggttaaagca gcgtttgtag atccagttgt atgctttttc atttaaatct 2770501 ctagggtttc cgaaggtttg cggatctttc attgcttctt tagacaagcg ttcgatcata 2770561 tcaggtgata ctccctgctc ttctaaagtc ggcacttcta aatcttcgac cagatcatac 2770621 atccaattga cagatgcttt cgcagcttct tctgttgtca tcttgcttgt atcaataccg 2770681 aacgctttcg caatacgcgc aaacttctca ggatagccct tccagttgta ttccatgaca 2770741 gggcccatca tcgccgctac acattggccg tgagcgactg ggataatacc gccaagcgtt 2770801 tggctcatcg catgagcagc gcccgctgat tcacttccgt aagaaagacc ggcaagcatc 2770861 gcagcctgcg ccattccgta ccttgcttcc agatcctctc catcagcaaa tgccctcttg 2770921 atgtaatgag cggcatactc aatcgccatt aaggcaaccg catccgtgat tggctgtgca 2770981 aatttcattg tatagcactc aatggcatgg gcgagcgcat caattcccgt catagctgtt 2771041 acatgcggag gcattgaaac atgaagctca ggatcaatga ttgtcaagtg cgctgcaatc 2771101 agcggaccgc ccgtgttgaa tttgaattct ctttcttcat ctgtgataac cgcccattgg 2771161 gttacttctg atccggttcc agctgtagtg ggaattgtcg tcagcggagg aatgcggttt 2771221 tccagcggtt ttttcccatc tgccgcttca taatcaagca cgcttccttc gtgagtcgct 2771281 tctactccga ttgcttttgc tgtatccatg gagcttccgc ctccgactgc caccaaacca 2771341 ttacagttct cttttttgta aagctcagat ccttcattca ccagacggac aggcgggttt 2771401 ggctcaactt tattaaagag taccacttca atgcctgctt ctttaagtga ttcgattacg 2771461 ggatcagcaa caccggcttt ataaatccca gggtctgtga caaggagcgc ttttgaaacg 2771521 cccagtgcag ctacttcctc acccgtatgc ttgatggctc cgattccatg cttaatcaca 2771581 gtcggaattt caaatgtgtg gaatttctgc atgctttcta ccttcatatt taatgtcatc 2771641 atcaatctcc ccctcttatg aattaaacca gttaaccgct gccggttttg tattgcggta 2771701 tacatgtttg acttctgtgt attcttcaag gcctattttt ccaagctcgc gtccgaaccc 2771761 ggattgctta tatccgcccc atggcgcttg tgcaaagtac ggatgaaaat cgttgatcca 2771821 aacggttccc attctcaagc gggctgctac ccgttcgcac ttttcaatgt cttttgacca 2771881 taccgctcca gccaagccat agatggtatc attcgcaagc tcgattacct cttcttcaga 2771941 gctgaaggtt tcgactgtca atacaggacc gaaaacctct tcctgaacga ttctcatgtc 2772001 agaattacag tttgagaaaa tagtaggttc atagaaaaag ccgttttgaa gctcaggatc 2772061 ttccgggcgt ttgcctcctg tctccagctt cgcgccttcc tctattccga tctctacata 2772121 tttttctacc tttgccctgt gctccgccga aataagcgga ccgctttctg tctcagcatg 2772181 aaaaccgttt ccgagtttta tgcgttttgc ccgtttgacc agctccgcca aaaattgatc 2772241 atgaatggca tcctcaacaa gcaagcggga acctgcagag catacttggc cggcgtggaa 2772301 aaatacagcg tttaaggcct gatcaaccgc aacttctaaa tccgcgtcct tgaaaacaat 2772361 atttgggttt ttcccgccaa gttcaagggc gatttttttg acgtttccgc ttgccgcccg 2772421 catgattttt ttgcctgttt caattccgcc cgtaaatgaa atcaaatcga cgtctttgtt 2772481 tacggcaagc tcgtcgccca ctgtggctcc cggtccaaga acaagatttg cgacaccttt 2772541 tggaacaccg gcttcttcca tcagcttaaa gactttgatt gtcgtcagcg gcgtaatctc 2772601 actcggcttc atgacgattg tgtttcctgc ggccagtgca ggggcgattt tccagctcgc 2772661 ttgaaggagc ggataattcc atggagtgat ctggccgcaa accccgattg gctccctaat 2772721 aattttgctt tctgaatcag gaatcggaga tgaaatgatc tctccgccat ctttgtctgc 2772781 caagccggcg taatattgaa aaacattggc gatatcgtcc atatcggcct tgctttcttc 2772841 gagtgttttt cctgtatcaa gagattcaag ctcagccagc tcctcaagat cgcgtctgat 2772901 taattccgca attttcagaa caatttttcc gcgttcaagc ccggatagcg atgaccattc 2772961 tcctttgtca aatgctctac gtgcggctgc gattgctttg atggcgtcct ctcgccctcc 2773021 ctcgcttaca gttgcaattt cttcttgatt aaatgggttg ataatactgc ggatctgttc 2773081 tttttcggca ctgatccatt ctccgtcaat gaataatgtt tgactcatat aagcctcctt 2773141 gacgtaaata aagtttgtta aataaaaatt taatgttttt aacaacctta atctaacata 2773201 tggtttttaa actgtcaaag tcccattttg atttttcttt ttgacttttc ctcatgtttc 2773261 gttaagataa agaacataaa gaaataactt aacgaattta attttctaaa ggaaaagagg 2773321 gtcagtatgg atgaaaatcc agaatttgca gctatagaac aggctcggga tcttgttatt 2773381 gactccattg ctgaaacgat ggatctttac ggaattaccc gcagtgtcgg gattttatat 2773441 gggacgatgt atatgaggga tgagatgacg cttgacgaaa tgcgtgagga gttgcaaatg 2773501 agcaaaccaa gcatgagcac tggcgtcaaa aagcttcaag acttaaatgt agtgaaaaaa 2773561 acatttcacc ggggcatccg caagcataca tttgtggctg agaaggattt ctttaaattt 2773621 ttcacaaatt tctttccacc taaatgggag cgggaggttc aagtgaatgt aacagcgatc 2773681 gaggaagctc aagctgattt acaaaaggtt ttatgcaagg aagatctcga tgaggatatc 2773741 aaaaatgaag cactgcagtt atatgatcag ctggaaagct ctaaagctta ctatgactgg 2773801 ctgaaacggc ttgctgaatc ggtgcagacc ggagaaattt ttaaatttat accggtcgaa 2773861 acaaagtaaa gcagaaaacg cctgggaaac taggcgtttt tttgatgtaa ctactacaaa 2773921 tttgaaaaat acgggaaaaa caccccattt acttccaaaa tatttgatgg taattttatg 2773981 taggtaaaat ttgtatttgg cctttcagag gaggtgaaaa gcgggcaggc ctgtttaatt 2774041 tatcattttt tagggggaat tttgttatga aacgcaaatt attatcttct ttggcaatta 2774101 gtgcattaag tctcgggtta ctcgtttctg cacctacagc ttctttcgcg gctgaatcta 2774161 catcaactaa agctcatact gaatccacta tgagaacaca gtctacagct tcattgttcg 2774221 caacaatcac tggcgccagc aaaacggaat ggtctttctc agatatcgaa ttgacttacc 2774281 gtccaaacac gcttctcagc cttggcgtta tggagtttac attgccaagc ggatttactg 2774341 caaacacgaa agacacattg aacggaaatg ccttgcgtac aacacagatc ctcaataacg 2774401 ggaaaacagt aagagttcct ttggcacttg atttgttagg agctggcgaa ttcaaattaa 2774461 aactgaataa caaaacactt cctgccgctg gtacatatac tttccgtgcg gagaataaat 2774521 cattaagcat cggaaataaa ttttacgcag aagccagcat tgacgtggct aagcgcagca 2774581 ctcctccgac tcagccttgc ggttgcaact aatgtaaaag accggttaac gccggtcttt 2774641 tttgcgtttt accctcccct ttttctctaa tccccgttat cttttttctg gtttaaaatt 2774701 taaattgaca aacactagaa acaggagtaa attcttgagt gttcaatttc atacagtctc 2774761 ttttaccgct taatcaaaca cgaacggggg aaccaacgat tggctgtttt attaacagcc 2774821 ttggggtgaa tcttactaag taagaggggg tactctgaat ccctaatccg acagctaacc 2774881 tcgtaggcgt atacagagag gaggtctatt atcggccatt ctttgcaatg gtcttttttg 2774941 tttcaaaaac gttaattcac taagggagat atgaacattg ggaagaatta aaaataagca 2775001 atttgccgtg atcgggctgg gccggtttgg cggcagcatt tgtaaagaac ttcatagaat 2775061 ggggcatgag gtccttgcgg ttgatatcaa cgaagaaaag gtcaatgcat atgcttctta 2775121 cgccactcat gcggtaattg ccaacgccac cgaagaaaac gaattgcttt cattaggaat 2775181 acgcaatttt gaatatgtga ttgttgccat cggagcaaat attcaagcga gtacgctgac 2775241 caccctatta ttaaaggagc ttgatattcc aaatatttgg gtgaaggctc aaaactatta 2775301 tcatcacaag gtgcttgaaa aaataggcgc tgaccgcatt attcatcctg aaaaagatat 2775361 gggggttaaa atcgcacaaa gcctttcaga cgaaaatgtt ttgaattaca ttgatctatc 2775421 tgatgaatac agtattgtcg agctgctggc tacgcgcaag cttgattcaa aatcgattat 2775481 tgacctgaat gtaagagcaa agtacggctg cacgatcctg gccattaaac atcatggaga 2775541 tatctgtctt tcccccgcgc ctgaagacat cattcgcgag caagattgcc tggtgatcat 2775601 gggccacaaa aaggatatta aacgttttga aaacgaaggg atgtagacaa aggtgacact 2775661 tcaaaaggat aaagtgatca aatgggttcg gtttacaccg cctcaagtgc ttgccattgg 2775721 ttttttcctt accattatca tcggggctgt cctattaatg cttccgattt ccactacgaa 2775781 gccattgtca tggatagatg ccctttttac tgcggcttcc gctacaactg ttacagggct 2775841 tgctgttgtc gataccggca ctcaatttac ggtattcggg caaacagtaa ttatggggct 2775901 gattcagatt ggcgggcttg gatttatgac atttgcggtc ttgatcgtca tgatattagg 2775961 aaaaaaaatc ggcttaaaag aacgaatgct cgtccaggaa gccttaaacc agccgacaat 2776021 cggcggtgtc attggccttg tcaaagtcct gtttctgttt tcgatcagta ttgaattgat 2776081 agcagcactc attttatcca tccggcttgt acctcaatac ggctggtcat ccggcttgtt 2776141 tgcaagtttg tttcacgcaa tatctgcttt taacaatgcc gggttttcgt tgtggcctga 2776201 taatttgatg agctacgttg gcgatcctac agtgaacctc gtgattactt tcttatttat 2776261 tacaggaggg atcggattta cggttctgtt tgatgtgatg aaaaatcggc gttttaaaac 2776321 tttttcttta catacaaagc tcatgcttac aggaacgctg atgttgaatg cgatcgctat 2776381 gcttacggtc tttattttag aatacagcaa ccccggcacg ctcggccacc tgcatatagt 2776441 ggataaactg tgggcctcct attttcaggc agtgacgccg agaaccgcag ggttcaattc 2776501 tctagatttt ggaagcatga gagaaggaac aattgtattt actttattat tgatgtttat 2776561 cggagcagga agcgcatcaa cggcgagcgg cattaagctg actacgttca tcgtgatttt 2776621 aacatctgtt attgcttact tgagaggtaa aaaagaaacg gttattttcc gccgttccat 2776681 caaatatccg attatcatta aagctttagc tgtgagcgtc accagtttgt tcatcgtgtt 2776741 tttagggatt ttcgccctga cgatcacaga acaagcgcca tttcttcaaa ttgtgtttga 2776801 aaccttttcc gcattcggaa ctgtcggcct tacgatgggg cttactcctg aactgacaac 2776861 agctggcaag tgtatcatca ttgtcatcat gtttatcgga agaattggtc ctttaacgtt 2776921 cgtgttttca ttcgcaaaaa cagagcaatc aaatatccgt tatcctgatg gcgaagtgtt 2776981 tacagggtga tatcaaaaaa atccggcgtg cagtcgccgg attttttatg attcgatatg 2777041 agattgattt tgtctttttt cctgttccgc gatgatttcg ttatcctccg cgttatcacg 2777101 ggtcactttt tgcgtaagaa tcgcaccaac tgctacaagt atcataacag cgatgtaata 2777161 acctttttca ttgagttcca gattatcagc attatagagt ccgatactaa acaaaaatac 2777221 tcccgcaaaa aaagtaaaat aagctagtac tgtaaaggca accgtgtttc tgcgtctata 2777281 tttctgcacc tttgttccct cccgaaagca tagttaaaaa gtgataactt ccgtggaata 2777341 ttatacctca aattccccgg aatggaacaa agaattaaaa ataccagtaa aaagggctta 2777401 ggttgcctcc tttatttcaa cagctgaatc atcaatccag ccgataagtt tatcattgat 2777461 ttggaattgg taccatacag actggccttt ctgtttttta gacacaacct ttatgtcttt 2777521 gccgacgtaa gattgggcag aggtaagcct tatggaccga tcatcagtag aaggcttgga 2777581 ccatacgtct tgaacggcac tgtctttaat agaggcgttt aaatccacag atttgaggga 2777641 tggatttacc tcatcgtact catctaaatc gtatttttcc acaatagcgc tgattttgtc 2777701 agcgtagtca gggtctgtag catatcctga tgtttgcagg gcggttgccg cttccttata 2777761 attccctgcc tcaagcaccg gtttatactt ctttttattc cacgatgtgc cacggacgaa 2777821 caattgggcg tgatcatcca tagattcaaa aaacgtgctg tattttcgaa acttcgcgcg 2777881 aatggttttt cttttccctt tttcaacttc gtccgtttcc atcgtgacat gatggccttt 2777941 ataattccct tttacgccaa aaaggttgtt ggccttagca gccagttcac tgttccccca 2778001 gtccgattcg agaatggcct gagcaattgt gatgctgggg agaacatggt atttttcata 2778061 caaaatttgg gcatgtccgg acagactgtc tataaatact tgctgttcat cgatttcttc 2778121 agtttctttg gatatttcaa tcggttttga taaagttgtc gctaaaacaa acagagctag 2778181 cggaatcgat acaaggaaaa atagtgaaat caagagttta cgttttttaa gttttttacg 2778241 ggccatgaaa accttccttc gaattaaaag attacgaatg taaaagaatc taccttttag 2778301 aattttactt gcacttctaa tatttttcaa ttctttaggg ataaagttgg gaaaagattg 2778361 caaaataaaa accttttcgc tcaatgaaaa ggtttttacc atgtttctat ttttgtaaat 2778421 ttctgagtgc attccgatat tccgtatcat ttattacttt atatgatttg acagttgcct 2778481 tcgacaaacc ttgtgctgag acggccggtt tttccggagc tgttttcgct ttatcatgtg 2778541 gtttatgtgc cagcttgtgc cccattccag tggcattcat acaaaatgac aggcagacga 2778601 gcagcacgct aaggataaaa gaaatgaaga agagatcatg ataagcagtc atcatagaat 2778661 cctgtaccga accgctttgt ctggcagcat cttttttcgt gaaaaagccg atgagaatgg 2778721 gaactcccat atagacaaac aatcttaaaa actgaacagc tgtcattctc ttgaccaaat 2778781 caggcagcgg gcctcccatg gcagctccca tcagccctgc ggcgactgtc aggcctgttc 2778841 ccgctgcaag catgataaac agtgccgcga acatataaag agatgatcga tcctgtatat 2778901 gcagccattg aaaattcaca aaaacgagaa tgagtccgcc gataataccg agcatccctg 2778961 gtccgacttt atcgtataac agagcgctca aaatggccgc gatcgccact ccgattaaaa 2779021 gagtcaagct taaaagaatg agatgctcct gagaaatatc atacatttga cggagcaagc 2779081 cttgaaaagc agaaaggctg acagctaccg ttatcgtccc tgcagctatg atcaataagc 2779141 cgagcaccgg ttttggcagc agcatcagtt taatagatat gaaggggttt ttcactttat 2779201 attccacaat caatagacca atgagcaaac ataacgtcac cccgaaacca atccatacat 2779261 aacccgatga cagcccccat ttttgcagaa aaatgaatga aaccgctgag gctgcggcaa 2779321 ggaagacaga taaaagaatt cccgcacgat caagcggctg ttcttgatcc gccgctccgt 2779381 gatgctcatc atgaagaaag aaatagctca ccgcgacacc gatcagggac aaggtgccaa 2779441 agatgaaaaa cagccatctc caatgcccgc agcttgttgc aatggttccc aggattgtac 2779501 cgatgataac agaaccatag aatcccccga tcagcacaag cagtgcatag ttcctgcgtt 2779561 caatcgggaa tgacagtaca agcattggaa tcataatcat cagcatgacg cctgttgccg 2779621 ccccttgtaa aaagcgccct gccgccatca atgcaatatc gcctgaacat gcgatgagca 2779681 gtgagcctag tataaagaca ggtaatgaag ccagatagac gggacgagca ccgaattttt 2779741 tcctcagcag cggtcctgcc ggaactaaca aggcaaaggc catattgccg atcaatatcg 2779801 gatttactga tgtaaagaca cttgttccaa ccgttttctg aacaaggcct tgaactgacg 2779861 acaatgccgt gttagacatc aatcccggcc cgaccgctaa gacggcgagc aaagaaatca 2779921 cccaatagtg ttttgtcttc atgttgtcat cccttcctat atgaatacat gcgaaacaca 2779981 tcattttttg aaaacaaaag aagctaatag attttgcata ccattagctt tcattctaat 2780041 attctccctt tcaggggaaa tgatattatt ttattataat tatgtgaatg aatgagcata 2780101 taatcaaata ttatttcaaa tcgattgtgt tttgtcaatg gagtaaattt caagcacaac 2780161 atagaaagct tgaaagcttt tccccgatat tgtgtctaga actgcactta tgaatccctg 2780221 ctcgttccct caagcgaatt aaagcaggcc gttttaatcc tttcaatcca ctattccaac 2780281 taataaactc aaataagttg gtgataagac aacattttac ccccacattt ttttgtgttc 2780341 actgggcgtt tgccgcctct aaattgtata tgggtaaata ccatgaatta acctatgaaa 2780401 taccaatgta agggaggcaa aaacgaatgg aactgtatga gtgtatccaa gacatttttg 2780461 gcggcttgaa aaatccatcg gttaaagatt tagcaacgtc tttaaaacaa attccaaacg 2780521 cagcaaaatt gagtcaaccg tatattaagg aaccagacca gtacgcttac ggccgaaatg 2780581 ccatctatcg aaataatgaa ttggaaatta tcgtgattaa cattccgcca aacaaggaga 2780641 caacagtaca cgatcatggt caatccattg gttgtgcaat ggtgttagaa ggaaagcttc 2780701 ttaattctat ttatcgttca accggcgaac acgcagaact ctccaattca tactttgtcc 2780761 acgaaggaga atgccttatt tcaaccaaag gtttaattca caaaatgtcc aatccaacat 2780821 ctgaacgaat ggtgtctctt catgtctact cccctccttt ggaagacatg acggtctttg 2780881 aggaacaaaa ggaggtattg gaaaattcat gattgacaga taaactgctc actttgactt 2780941 cactcaactg gaggattcag agaatgaaac cttttcctca aaacaaaaaa acccttatcg 2781001 aataagggtt taaaggtatg gagccaaggg ggctcgaacc cctgacctct acgctgccag 2781061 cgtagcgctc tcccagctga gctatggccc cgtatgtaac gtcatgttta ttatagatga 2781121 ttttattttg aaaaacaagc tgtttcctct tgaattgaca gaaaaaataa ggctcggaaa 2781181 agagccttat ttttcgactt acatcatgat caaaagtaaa atcacaccga gaataattcg 2781241 atagattgca aatgggacaa gtttgatttt gttaatcagc cttaagaaga aacggacgac 2781301 aaacagtgcg accacaaagg cacagataaa gccgacgatg aaaaacggca tcagatccga 2781361 acttaagctg tcccaatgct tcacgaggct tagaaagctg gctcccatca tgatcggcat 2781421 cgccataata aacgtaaagt cggctgcagc tcggtggttt aatccgagaa taacaccgcc 2781481 ggaaatggtt gaacccgaac gcgagaaacc aggccaaagg gaaagacatt ggaataagcc 2781541 gacggctatc gcctgtttat aggaaatgcg gtcgagtgtg tctgtcgctg ttttccgttt 2781601 attgacccag tcagcaaaaa gcatgaggat tgccccggca attaaaccga tggccacagt 2781661 tttaacggaa aataaatatt catcaatgta atcttcaaac aaaaagccga gaacagctgc 2781721 aggcacgagt ccgacggcaa tttgggcaat gcttaattta tgtccctgct cctggtcgct 2781781 tgtaatattt tttttcaagc ccagtaaatt taaaattcgg tctttaaaca cgatagctac 2781841 tgctaaaatg gagcctagct gaataaccac cttgaatgag ttagcagctt cttctgacat 2781901 cagattactt gattttagcc agatgtcgtc tactatgatc atatgtcctg tcgaagaaac 2781961 cggcgcgtac tctgttaatc cttctacgat tcctaaaatg gcggctacaa acaattccca 2782021 tagagtcatg attttgattc tccccattag acatttattt ttttacataa cgggagcttc 2782081 ccataaatgg aaagcccgtc ttatataact ataaacgaaa atcacacttt atgccccggc 2782141 gtattttcat ttttttcttc atcgtataaa tgtgactgca ttttaaacca gtcaaataaa 2782201 tgtgtcgtaa tgactttggc aaccgcatag ccgggaatcg caagaatgat tccaacaacg 2782261 ccaaacagct tgccggctgt taacagcaga aaaataatcg taatcggatg gatgtgaagg 2782321 ttttttccca taatttgcgg agagatcagc ttcccttcaa tcagctgaac aatcgtccaa 2782381 acgatcacca gcttaagcag catgagcggc gatgtcacta tggcaatgat aatcgcaggc 2782441 gtaatggcaa tcgttggccc taaatatgga acgatgcttg tgcaagccgc aatgactgca 2782501 agcaatgaag cataatccag cccgataatc aaataaccga taaacagcaa aaacccgata 2782561 cagaagctga caatgatctg gcctctgata taagagctta accgatgatt catttcgctt 2782621 aagactgtat atgtctgttc tttcaatcga gtcggcacaa acttcagtat gtagaccggt 2782681 aattttcttc cgtcttttag caaataaaat agaataaacg gaaccgtgac gatcgaaatg 2782741 ataatctcag tcagtgcgcc gataaaattc ccaacaccgg taaaggtgct gttcacgatc 2782801 gtcgctgcct gatccgaaac ctttgtagca agatcagata tattaatgtt catcgtttgc 2782861 tgggcctgat tgacgaagtt gctgccaatc agctgtttcg tctgattttc tacgacgtcc 2782921 acatatctcg ggatattgtc aatcaaactc ataatttgtt cttttaagaa gggaatgatc 2782981 gacacgatcg tgatcgtgat cagcccgata accaataggt atagcagcaa tatagaatag 2783041 attcttctta ttcttcttct ctccagaaaa tcgacgactg ggtttaacag ataaaaaaca 2783101 atgcctgtca aaataatcgg aagtgatatc gttttgagca gaacaataat cggggtgaaa 2783161 ataaatgatg tttttgtaaa tactagaata tttaaaccaa tcagcagcag cacaagcaaa 2783221 aataaaacaa acttattatc caagaagaat cgcttgaatc tgccgctcca tgtttgcaac 2783281 gtctccacta tcgttcctcc gtcatacata gtttaattaa attgtacact atcgtcccta 2783341 taatgaaaaa taaaaaccgt taattgctgg aaaagctttc tcggttttaa cattctattt 2783401 atatctatca tgtgattttg ttctttttaa gctataattt agctatatca tgcaaaagga 2783461 gcgatacgag tgatacgttt tgcaataata ggaaccaact ggattacaga ccgctttctt 2783521 gagtcagcag cggatatcga agattttcag ctgactgctg tttattcaag atcggctgaa 2783581 cgcgctggcg agtttgctgc taaacacaac gctgcgcatg ccttctcaga ccttcaggaa 2783641 atggcggcga gcgattgctt tgatgccgta tacatagcga gcccgaacgc tcttcacaag 2783701 gaacaagccg ttctctttat gaaccatggc aagcatgtgc tttgtgagaa gccgtttgct 2783761 tcgaatacaa aagaaacaga agagatgatc tcagcggcta aggcaaacgg cgttgttctc 2783821 atggaagcaa tgaagaccac tttcctgccg aatttcaaag aactgaaaaa acacctgcat 2783881 aaaatcggca ctgtccgcag atttaccgca agctactgcc agtattcctc acgatatgac 2783941 gcgttcagaa gcggaactgt tttgaatgcg tttcagcctg agctttccaa tgggtcatta 2784001 atggatattg gcgtctattg tatttatccg gctgttgtgt tgtttggcgc gccgaaggat 2784061 gtaaaagcaa acggatatgc tttatcctcc ggagtggacg gagaaggaac tgtcattctg 2784121 tcttacgacg ggttcgaagc tgttctgatg cattccaaaa tctctacttc ctatgccccg 2784181 gctgaaatcc agggtgaaga cgggacgatt gtaatcgata cgattcaccg gcctgaacgt 2784241 gttgaaatcc gctaccggga cggccgcctt gaaaacatcg cgatccctga tcctaaaccg 2784301 gcgatgttct atgaagcaga agaatttgtc acgcttataa aagagaataa gctggaatct 2784361 gaagaaaata catttgaacg gtctttgacc accgcaaaaa ttatggaaga agcaagaaag 2784421 caaatgggga ttgtataccc tgctgatcaa gcttaaaaaa atccgcccgc gtgcaaatgc 2784481 cgcggcggat tttttattag acaatcggag aagatgcctt cctttttaaa agcacctgtt 2784541 gctcatattc tttgatgtca taaagccatg cctcttttac cggaacgccc atttgctcac 2784601 agtaggaatc ccagatggct ccgaaaggat atgttttgaa ttcctccatc agggccagcc 2784661 tttctgtata gcggccctct tcctgcaatt gttttaaata tccgttcggg agaagcaggg 2784721 catacaataa agctttgatc atatttctcg ttccgatggt ccaggcggct acacggttaa 2784781 tgctggcatc gaaaaaatcc agaccgatgg ctaccttctc aagagcatga tttcgtacaa 2784841 tttcaagagc gatttctctc aattcatcat ccaaaaccac tacatggtcg ctatcccaac 2784901 gaacaggccg cgatacgtgc aaggcaagct tgtctgtgta aagcagcatg gacgagatct 2784961 tgtttgatac cgtctcagtc ggatggaaat ggcctgtatc aagtaaacaa agcttatgat 2785021 tcgtcaaagc ataagctaaa taaaattcat gagatccgac aacatatgat tcggagccaa 2785081 gcccgaacag cttgctctcg attgaatcaa gattatgttg ttcactgatc tcctctgaga 2785141 agatccgatc cagtgattct tttagtcttt tacgcggtgt cagcctatca ctcgggatat 2785201 ccttatagcc gtcgggaatc caaatattcg tcaagcaagg tgttcctaat tctttcccga 2785261 agtattcccc gatacggcgg caagcgatgc aatgcctgat ccaaaattct ctgatgtccg 2785321 gatcagggtg tgaaagggtg agtccgtcag ccgctttctc atgcgaaaac aaggttggat 2785381 taaaatctaa accgagacca aggttttttg cccatttcac ccagttttca aaatgctgcg 2785441 gcttcaattc gtcacgttct accgcttccc tgtttgtttc tgcgtatatc gcatgcaggt 2785501 ttacgcggtg ctttccagga atgagagaaa gagccttctc caaatctctt cttaattctt 2785561 caggagtttg cgcttttccg ggataattgc cggtcacgtc aattccgcct gaaagctcgc 2785621 ccttatttac ttcaaagcct tcaatgtcgt caccctgcca gcagtggatc gaaatgggca 2785681 cttgctctaa ttgccgaagc gcctcttcaa catcaattcc ccatttttca tatgcctgtt 2785741 ttgcactgtc ataattggct tttatggtca tacggctctc tccctttatc agtttttcaa 2785801 tccaaataaa aaacttcctt tagatctatc gcaacaggac tgaaatccga atttgttttc 2785861 attaatggcg ccatcgattt ccaccatctt tggcaaactt ccgtgtccgc catctttctc 2785921 catttctctt catcctctat ttctaaatat gcaaaaagcc tgcctgtttc ctcgtctaga 2785981 aaaatggaat aatggtgtgc tccatgagct ttgagtgctt ctgccatctc aggccaaatg 2786041 tcatcatgcc gctgtttgta ttcttcgtac ttgtcttgat ggacaaacat gatactggct 2786101 tttcttttca aaccttttca cctcttcatc atttagatag cgctttcaaa acagtttgct 2786161 gaaatgactg aatgatcgtg cttctatcaa tgtctttagg tgtaaacact ttgatcggaa 2786221 aggaatttct gacgacttgc cgggcttctt ttatgtcttt gacttctttg gcagcaatca 2786281 tttgcatcaa aagatttccg gtggcagttg cctctatcgg ccctgcatat accgcttttc 2786341 cactcatgtc tgccgttaat tgatttaaga aatcattccg ggctccgccg ccgatgatat 2786401 gaaattgctc gatcggtttt tctgtgattg tttcgagctc tttgatggct atcgcataga 2786461 tgatggctaa attgctgtag atgcagcagg caagttcgcc tgcagtacgg ggaatctttt 2786521 ggcgggtttg tctgcaataa tgttgtattt cctttatcat gttttctgga ttcaggaaac 2786581 gtttatcatt taagtttata aattgctgga atggttctgt ttttttggct tcttctgcaa 2786641 gctgctgaaa agaataatct gcttgtagct gctgtttgac ttcttgtatc acccacatgc 2786701 cgataatgtt tttgagaaag cgaatggtgt tgtttgcgcc gcgttcattt gtatagttgt 2786761 tttctaaagc aagatcagtt attatcggtg ttttgttttc aaccccgatt aacgaccatg 2786821 ttccgctgct gatatacgcc cagccatcat ttacgcctgg cgccgcaatg acggccgagg 2786881 ccgtatcatg tgttgcgact gtcatcacct tgcacgccgg gagatcataa tccgggaacc 2786941 actcatttct tagcttcccg agttcacacc ccggttcagt gagcggcgca aattgctgtt 2787001 ccagaacaga cacggcttca agcaattcag gatcaagatt tcccgttgag acgtttaaaa 2787061 gctgtgttgt ggacacgttt gtgatttccg ttacagcttt tccggttaaa caatagccta 2787121 aataatcagg aatcatcata attttgtctg tctttttcag cagctcacgg tcttcttcaa 2787181 acaattgata gatcgtgttg aaaggctgaa attgtattcc tgttttttga taaattgcgg 2787241 cttttgagag ggtatgttcc agtttgtcta ttgtgtgatc tgttcttcta tcacggtagg 2787301 agattgcttc ccgcaaccga tcgccttttt cgtccagtaa gacataatcg actgcccatg 2787361 tatcaatgcc tacggtgcag tgttcatacc caagcgtctt tactttttgc agtccttgca 2787421 ggatttgttt tagcaaatga tcaatatccc ataagcaatg cccgtctctt tgactgaaac 2787481 cgttagcgaa cctgtgaatc tcttgtatgt caagcttccc ttcattcagt tcacctacca 2787541 tgattctccc gcttgatgcg cctacatcaa tggcagtata aatcatcctt tcaccctctc 2787601 ttcgaaagag gaacagctgt caccttcacc tttttgtcct caagagcttt taccgatgcc 2787661 ggatcaagtc cagaatccgt aataaggcgg ctgacatctt gcagcgaggc gatatgtgaa 2787721 aactcgcggt tcccccattt gcttgaatcg gccatcaaaa tggtctggtc cgacctttcg 2787781 atcatccgtt ttttgagcag cgcctgccac tcatttgaat cactcatccc gttgtgtacg 2787841 tcaaatccct tacatgacag aaaggtttta ttgacatgat aggtctcaag tgaacgctct 2787901 gctaacgggc cggcaaatga taatgatttt tccagcaaaa tgccgcctgt tgaaatgact 2787961 gatatgtttt ctttattgct gagttcaata gctgctttca ttgagtttgt aatcacggtg 2788021 agctcaatgt cagggagtat ttttgccatg taccaagcgg ttgtgcttgc atcgagaatg 2788081 attcggtctc cgctttttac atatttggcc gcttcgtgag cgatggcttt tttttcgatg 2788141 acattcgtga tttcccgttc agaaaaatga atttctgatt ccttctgctg aatactgacc 2788201 gctcctccgt ggctccggct cagtttatgt tctttttcaa gcttttcaag atcacgccga 2788261 atggtttcct ctgtgactga aaaaatgtca cttaattcgg aaacgcggat gcttgaacgc 2788321 atatttacta tttccactat tttttgctgc cgttctgcta ctagcatcgg taacgccctt 2788381 cctcatatcg tagtccgtct tatattttta tcatagcata tatctaacgc gtaaaagcag 2788441 cagggacgcc gccgtctacc gtgatcatgc agcccgttgt tttttcggct ttggaagaag 2788501 cgaagaatgc aatggcttcg gcaatatcct ccgggtaaat attgacgagc aatgctgtcc 2788561 gtttccggta atgttcctcc agctgatccg gttcaatccc gtacgccgcg gctcgttcct 2788621 cacgccagct tgaaccccag attgccgatc cttgaagaac tgcatcaggc aaaacggagt 2788681 tgaccctaat gccgaattct ccgccttctg ctgcgatgca tcttgctaaa tgggtttcaa 2788741 gcgccttaac agagctgtag gcagaggcgt tttttcccgc ataaactgaa tttttcgatc 2788801 cgacaaatac catgcttccg cctctatttt gatgtttcat ctgtttaaac gcttcacggg 2788861 ctacaaggaa atagcctgtt cctaaaacat tcatattaag attccattct tttagacttg 2788921 tttcgtcaaa tgggcttgat gtggccagcc cggcattatt gacgacgata tcaatgccgc 2788981 cgtaagcaag cgccgctcgt tcaaaagctg actgtacgtc ttcctccttt gtcacatcca 2789041 ttttgacagc cattgcccgt ccttttccgt atgcatcgtt tatttccccg gcaattttct 2789101 gtgcgccttc tatattcaga tcagctacga tcacgtgccc tccctcagct gcaaatcggc 2789161 ggcatgccgc actgccgatt ccgccggctc ctccagttat cagcgctact tttcgggaaa 2789221 attctgcttc cggcggggcc agcgtgagtt tatatagttc gagcggccaa tattcgacat 2789281 ggtaggactc attttcatgt aaagaaacaa attgccccag agcggttgct cctttcatta 2789341 cggcgatggc cctccgatat aaagccccgc ttactttaga catcgcataa ctttttcctg 2789401 tattcaccat tccgattcca ggaatcaata tcacccgcgg ggcggattca aagatttgat 2789461 ccccatcctg ctgattgcgt gtaaagtaag cctgatactc tgatgtaaag gtctcgactc 2789521 ctgacttgat cagatctgca agcttgtgca catcttgagt ttccggattc caatcaatgt 2789581 acagcggaac ccgttttgtg tgaacaaggt gatccgggca tgccgcaccg atttgcgaaa 2789641 gtgctggcgc ttggacactg tttacaaatt ccaagacatc gtcatgatca tcataggaaa 2789701 ggatcatttt cttttcttca cttactgctc ctctgatcac aggcatgatg cctgccaaga 2789761 tttgttttct tttatcctcc ggcagcggct gatacctttt gcctccgaat acctcatgct 2789821 gattgatacg atcgttaata tactgctcgg cttcttgaat gatggatatc gttttttgat 2789881 aacatgtttc agacgtctct ccccaagtga ctaagccgtg tttctccatt aatacaagct 2789941 cggcgtgggg gttgtttgct acgccttcag cgatcatttt agacaaagta aatccaggac 2790001 ggacgtatgg cacccataca aaccgatttc cgtaaatgtc ttcagcgatt tgttttccat 2790061 tatccgcaca gcatatgctg ataatcgcat ctggatgggt atggtcaaca tgtttgtatg 2790121 gcagaaaagc gtgtaatagc gtttcaattg aagggcgggg atgtttgctg tctatcatac 2790181 aatgagacag gtagtctacc atttcttcat cgggcatttg gtccctttta atcagcgggc 2790241 ggatatcatc taatttcaaa ccggaaaagt tatgcgcttt cattgttgcc aaatccgatc 2790301 cgcttccttt tacccacatg acttctattt cacggcctct aaaatccttt tccgttgttt 2790361 tcatagatgt attccccccg ccccagttgc agacagtgcg gtctgacccg atcagattgg 2790421 acctgtacac caattcctct acacctttag gtagctgtgc agctcgctct gaatcccata 2790481 tatgtttcac catatttgat attcctccat acccttttat ttgtatccgt tttcattata 2790541 tatgatttct gtttgttttt gaatcgtttt tgtttatttt tgctttttaa caaaaaaaga 2790601 aagcagcaga tatgccgctt tctcgtttca ttatgattct attttaaatt tcttcgtaat 2790661 gtcctgaagt tcttccgcca tgtttgccaa cgtttccgct gaagagctga tttcttccat 2790721 ggacgcaagc tgttcttccg ccgaagctgc gatatcctga atgcctgctg agctttcttt 2790781 cgccactgca gaaatatctt caacagcact tgacacttcc tgtgatccgg ctgacagttg 2790841 ttcaaccgtc gcgttcaagt tttgcaattc gccggaaatt tgggttgtca tctcatagat 2790901 ttgtttaaag ctttccgctg tttgatccgt aatctgcaag ccttctttca cttcatgatt 2790961 cacggattgg aacattgaaa gtgaggtgct gatttccctg acaatctctt gaattaatcc 2791021 ttcaatttcc ttggcggagt ctgctgattg tacagcaagt tttctaacct cttccgcaac 2791081 tactgagaaa cctcttccgt attctcccgc tcttgccgcc tcaatcgcag catttaatgc 2791141 aagcaggttg gtttgatcag caatgccgtt aatcacattc aagatgcttg tgatgtcttg 2791201 cgattttgtt tcaaggccct tcacaaccgc ttccgctttt tgaacggatt ggtcaattgt 2791261 tttcatctgg ccgactgtat gctccaccag cttttctccg ctgcccgctg cctcagagga 2791321 ctgaatcgat gatttcgtaa tggttgaaga ggcttgagcc acttttgaaa tcccctcgtt 2791381 catttgagaa agatgatttg agcttgtttc cagtttctcg ctttgtgcct cgttgccatc 2791441 tgagaactgt tcgatggcaa gtgtaatatg ttcagttgcc ttgcttgttt gggctgcgct 2791501 tgctgtcagc tcctcagaag atgaagcgac gttttctaca gacgtttgaa taacgcctat 2791561 tacagaacgc aatgatgcag acatttcatt aaagctttcg ccaagctggc caaactcgtt 2791621 tttcgagtga atgtcaatga cttctgtgag atctccgctg ctgatttttg cagacgttga 2791681 gacaagtttt cttaacggct tggtgatggc acggataata tagagtatga gtatgccgcc 2791741 gattactatt gacacgcata gaatgataac cgcagtgttc agcaccgggc ttgaagcatc 2791801 ttgcaattca ctgacaaaat atgtgcccgc gattttccag ccagtcagtt tatttgtcgt 2791861 aaaggccatt ttcttttctt tgccttcgaa tgtatattca aatgagcctt cttttttgga 2791921 atatacttgg tttgtccaat cgccggaacc ggttgtcccc ggcttaatgg tcggatgggc 2791981 gatatatttt ttgttgcctg tcgtaataaa tgcaaagcct tcttttccga ttttgattct 2792041 ttttgatgca gtaagcactt catccaggtt taaatctagc gctataaccc ctgaaccgtc 2792101 ttttaattgt tttgaaattg tgacaacgat atctcctgtc gcttcatcgg tatacggttc 2792161 tgagaaaaca gcttgtcctt tttccgcaac cgcctgtttg taccagtcac gtcctgtcgg 2792221 atcgaaacct ttcggaacac cgctatccgg atatttataa agcttcttat cttctgaggc 2792281 agcatagatt gcgcctacat cgtcgttaag tgtcgtgtac tgcttaaatt tctctttcag 2792341 taatgttttg tttttgccta acaatatgtc tttatcgact gtctcactat aataatctat 2792401 tgcttttact ttatcttcta atttattttg cagcgtactg tttagttctt caacatttcc 2792461 cttcgcactg cttatgagct ctctgtctaa cgcgttccaa gctgattgat aactgaaata 2792521 tgctaaaacc ccaaccggca aaataagcac tgccagaaac gcagcgatta gcggtttgct 2792581 gatcgatggc tgtttgatcc attgtatgaa ttttcccatt ctcgttgact cctcctttaa 2792641 gataaatcta atatcgtcaa actaggataa aaggtttaat aaaaaaacta aaaaaaacac 2792701 ccaagcgcaa caagcttggg tgttaaggct tattattcaa ttttaaatcg tttggtcata 2792761 tcccgaagct cttccgccat agaggaaagg gtctctgcag acgagctgat ttcttccatg 2792821 gaagctagct gctcttcagc tgacgccgcg atatcttgta tatgcgctga gctttctttt 2792881 gaaatcgatg caatgtgctc agacgctccc gaaacttctt cggagctggc agaaagctgc 2792941 tgaaccgtcg cactcatatt ttgcagttcg ccggcgattt ggttcgtcat ttcagaaatg 2793001 cgtttgaagc tcatttctgt tttatctgtg atgtcaagtc ctgtctgcac ctcttgattg 2793061 acagattgga acatgccgag tgatgtattg atttccttca caatttcgat gattaatcct 2793121 tcaatctctt ttgctgaatc tgctgactgt actgccagtt ttcttacttc ttccgctaca 2793181 acggagaagc cgcggccgta ctcgcctgcg cgcgctgctt caattgctgc gtttaaggca 2793241 agcaggttcg tctggtctgc gatgccgttg atcacacgca aaatgtttgt aatatctttc 2793301 gatttcgttt ccaatccgcg tacgacttgc tccgcttctt taacggactt gtcaatgaca 2793361 ttcatttggc cgacggtttg atgaacaagc ttgccgcctt cacttgcaat ttctgtcgat 2793421 tgaacagatg aatcagtgat cacttcagaa gcttgagcca tattcgtcaa cccgtcattc 2793481 atttgataaa tgtgctctgc tgccgtttca atgttttcgt tttgtttttc attgccgtta 2793541 gaaaattgtt caatcgccaa tgtaatgtgc tctgttgcct tgctcgtttg cgcagctgat 2793601 gcagtcagct cctcagagga agcggcaaca ttgtctaccg aatcctggat ggcgtgtatg 2793661 agagaacgaa gtgacgacgc catattgtta aagcttttgc cgagctcgcc caattcatct 2793721 tttgaacgga tatcaatggt ttccgtcaaa tctccctcgc tgatccgctt agaggaaccg 2793781 acaagctgtt tcagcggtgt tgtaatcgac cgaatgatca atgtcatgac gataatccct 2793841 atgataatag ctgcggccaa gacaattaaa gcaaggtgaa ggacaggctg ggctgcctca 2793901 tggatttcat ccaaatacat ggtgccgccg atcttccatc ccgtcaactt gtttgtgtca 2793961 aaggccattt ttttcttatc gccatccatg gtgtattgaa aatcgccttt atcagcactc 2794021 aacatcttat cgagccagtc gccttttaat tcagttcctg attgttcatt agggtgtgcg 2794081 acaacttttt tgtccttcgt catgataaat gcgtagcctt gtgtgccgat gttgactttt 2794141 ttggttgttt tcagcagatt ttcaatcgtc atgttgattg cgataacgcc tgaaccatct 2794201 tttgtctgct gggcgattgt cacaaccatc gtatttgtcg acgcggtttt ataagggtct 2794261 gtgatcacga ctttcccttt atttgcaacc gcttttttgt accagtcgcg ttcaaccgga 2794321 ttatagccgc ttggcatcgg aagatccgga tagcgggtaa agtgcccttt tgtgtcactt 2794381 gtataaatgg attctacatc cttgttaatg ctgatatatt gtgagaattt ctctgcaatg 2794441 cttgcattgc tttttgcatt gtatttctct tttgtcagcc attcgctgaa ataatcagca 2794501 ctgttttctt tttcgccgat gctggtgtta atgatttcgt ttaattgctg tacattttcc 2794561 aatgcgctcc ccatcatctg tctgtcgagt gagctgctag ccgattgata cgcaaagatc 2794621 gccaatatga caaccggtat gatgaggatc gacagaaagg aaacgagaag cttccgtgta 2794681 attgatcttt gttttatgag ttggagtatt tttttcatca ttcatttctc cttttttatg 2794741 ctacccttca tatcggctgg aaatgggtaa atatatacag caaaaaagaa gaaatttaac 2794801 aaaagtaact aatttcccat aaataaatag tattttagac ctattatttg tctactttaa 2794861 attgttttgt cagatcacgg agttcttcag acattctttc aagcgtcagt gcagatgaac 2794921 taatctcctc catggatgcc agctgttcct cagctgaagc ggcgatatct tggatgccat 2794981 ccgagctttc cttagaaatg gcagtgatat catttgaagc tgcggaaatt tcttgagctc 2795041 ccgctgacag ctcctcaacc gtcgcattca tgttttgcag ctcggaagca atttgattgg 2795101 tcatttgcga tatatgtttg aagctctgtt tagtttcatc cgtcatgaca agccctgttt 2795161 caacttcttt gtttacggac tgaagcacgt tcagtgatgt gtgaatttct tttactattt 2795221 cactgatcag cgattcaatt tcttttgctg agtcagccga ctgtaccgcg agctttctca 2795281 cttcctcagc gacgactgag aagccccggc cgtattcacc cgctctggca gcttcaatgg 2795341 cggcatttaa agccaaaaga ttggtttgat ccgcaatgcc gttgatgaca cgcaaaatat 2795401 tcgtgatatc ctttgatttg atctccagcc ctttcaccac ttgttccgct gcttttacgg 2795461 aatggtcaat tgtgttcatt tggccggctg ttttctggac gagtgtctcc cctttgcttg 2795521 acacttcggt tgaatctgcg gatgtttctg taatcactgc tgcagcccgc gccagctctg 2795581 ccaatccgtc attcatttca ttaatttgtt cggttgtcgt ttctattttc tcgctttggc 2795641 tttcactgcc gtttgaaaat tgctcgatag ccatcgtaat gtgctcagtg gctctgcttg 2795701 tctggtctgc cgatgcagtc agctcttcag acgaggaggc aacgtgttct actgagtctt 2795761 tgatcccgtg aatgagcgag cgaagcgagt gtgccatatg attgaagctc tcactcagaa 2795821 cgccgagttc atcttttgaa ttgatttcaa tcgtttcggt tagatcgcct tcactaattt 2795881 tttcagcgga tgcgacaatg cgtctcaatg gctttgtgat ggatcgaatc acaaaataaa 2795941 tcgccgtcat tccagctccg atggcaatcg ccagaacgat tgaagccatg atcagaaccc 2796001 tgcttgcagc atcgtgaatc tcgtttgcat acatcgtgcc gctgattttc cagcctgttg 2796061 tttggcttgt tgcaaatgcc atttttttct ttttgccttt gtacgtatat tcaaagtccc 2796121 cgcttttatc cttgtagagc ttatcaaccc agtccccttt tagctctgtt cccgcttttt 2796181 ctccggagta ggcgatgact ttcttgtttt ggctcaaaat aaaagcatag ccttcttttc 2796241 cgatattgat tcctttcgcg gtagtgacta agtcatcaat tttcatatca atggcgacaa 2796301 cgcctgaccc atccaccgtt tgacgggcga tggtgacgac catttttcct gatgaaatcg 2796361 attcataagg ctcagtgaca attgttttgc ctttattggc cattgcttct ttgtaccaat 2796421 ctcgttccaa agcattaaag tcgcttggca tgtcagcgta cggataacgt gtgaagtccc 2796481 cgtctttgcc gcttgaaaat accgcagcga cattatcatt catttggata aattgtttaa 2796541 attcctgttt cagctctgtt ttctttttat cctgaaattt ttctgctgta gcccaatcgc 2796601 tgaaatatgc gaggcttttt tcagtagtgc tgattttatc atcaatgatg tgatctaata 2796661 tctgaacatt ttcctttgcg ctttgcgtca tctgtacatc aagtgaggca actgctgatt 2796721 gataagcgct aaccgaaagg gcggttatcg gaacaattaa gatcagcagg aaagaaataa 2796781 taagtctcct tgcaattgat gatctgcgaa tagtggtgag tgtttttttc atttcctttt 2796841 gaaccttctt tcaataattt acaaattata tcggcggatc ttcctttaaa ttacattgaa 2796901 aatggaggaa aaaatgaaaa atagttctaa attcacctgt taaactagga ctttattatt 2796961 gtttaccata taaaaaaaca gcgctttgat agcgctgttt ttcggttttt actcgatttt 2797021 aaattgtttc gtcagatcgc gaagctcttc tgccatctgc gcaagagtcg tcgctgagga 2797081 actgatttct tccatggaag caagctgttc ttcagctgat gcggcaatgt cctggatgct 2797141 tgccgagctt tctttcgaca cgtctgcaat gccgctgact gctgctgaaa catgctgtga 2797201 acggtctgac agctgctcga cggtggaatt catcgtctgc agcttgcccg cgatttcgtt 2797261 tgtcatgctg aaaatgctct ggaagctttc ttttgtattg tctgtgacaa caagtccgga 2797321 ctgtacttcc tgattgacct ctttaaacat gtgaagagag gtgtcgattt ctgcgacgat 2797381 ttcttggatc agcttttcga tttctttcgc tgaatcggct gattggacag ccagcttgcg 2797441 cacctcctcc gctacgacag agaagccgcg tcctgactct ccggcacgcg ccgcttcaat 2797501 ggctgcattt agtgcaagca gatttgtttg gtcagcgatt ccgttgatga ctctcaaaat 2797561 gcttgtgatg tcttttgatt ttccttctaa gcctttgaca acagcttcag cctgctgaac 2797621 agattgatta atcgagttca tttgtccgac tgtctgctgc acaaacttct cacccgttcc 2797681 ggcgatttcc gttgattgga tagatgcctt tgtaatatct gacgatgttt gtgagacttg 2797741 ctggagtcct tcattcatta agttcagctg atgagagctg gattcaacct tttcgctttg 2797801 ctcctcgttt ccgtttgaga actgctcaat cgccatcgta atatgctcgg tggctttact 2797861 cgtctgcccg gcagatgcgg taagctgttc ggaagatgcg gccacattgt tcaccgagtc 2797921 ctgaatagcg ctgatcagag agcggagaga ttgtcccatt tcattgaagc tttccccaag 2797981 ctctccaagc tcatcctttg aatggatttc gatcgtttcg gtcagatccc ccctgctgat 2798041 cgttttcgat gattgaacaa gacgttttaa cggttttgta atcgaacgaa cgataaacag 2798101 aattaaaatt ccgcctgcca caatggaagc aatcagcaca atcattcctg ttgtcagcac 2798161 agactttgag gcatccttaa tttcatccat atacattgtg ccggctattt tccaaccagt 2798221 cagttcgttt gtagtatagg tcatcttttt atcttcgtta ttaagagtat actggagttc 2798281 accgctgtca ttcgcataca ttttggctac ccagtcgcct gaaagctttt ctccagcctt 2798341 atggttcttg tgggcgacat aggttttgtt ttttgttgca atgaaagcat aaccttcttt 2798401 tccgaccttg atttgtttca tttgttctaa caatttatca atggtaatat ccatggcgac 2798461 aacgccagat ccgtccttca gctcctgtgc aatggtaatg accatgcttc cgtcactcgc 2798521 agccacgtaa ggatctgtca cgacaatttc accgccggcc ttcatcgcat cctggtacca 2798581 aggccgttgt ctcgggtcgt atccttccgg caatttttct tttggcgctt gtacataagt 2798641 gccgttatct gcgcccccat aaattctggc tactccttga ttaatagata catattgtga 2798701 aaatttagct ttgatctctt cttgatttga tttccctttg aatgcggatc ttttaagaga 2798761 ttcactgaaa aaggtgactg ctttcgcttt ttctcccaga tcatttgtaa cagttgtatt 2798821 aaatgtatcg acactgtttt tcgcatttcc cataatttcc tgatccagct ttccgctggc 2798881 gcttcggtaa gagctaaatt ctaatataag aatagggata atgagaatcg caataaatga 2798941 gacgattaat ttctttgaaa tagacggttt cttcagccaa ttgataaaag tcttcatgtc 2799001 acttgctcct tcaggtttga tacagtatat atcggctgct taaaaaagtt ttaaaataaa 2799061 aaatggaaga agttcttttt ggctgtcttc tgccttttta actttcattg cccaagctct 2799121 ttgcatatct tataaaaaac aaggggggct aaacatgatt attgtatcag gacaattgct 2799181 ccgtccccag gatattgaaa attggcagat tgatcaagat ctgaatccgc tcttaaaaga 2799241 gatgattgag acgcctgttc agtttgatta tcattcaatt gctgaactga tgtttgagct 2799301 taaactgcgg atgaatattg tagcagcggc aaagacgctg cacaaaagcg gggcgaagtt 2799361 tgccactttt ttaaaaacat acgggaatac aacgtattgg agggtttcac cggagggcgc 2799421 cttggagctg aaatacagaa tgccgccttc aaaagcgatt cgggacattg cagagaacgg 2799481 cccgttttat gcgtttgaat gcgcaaccgc aatcgttatc atttattact tggccttaat 2799541 cgatacaatc ggagaagata aattcaatgc cagctttgac agaattattt tatatgactg 2799601 gcattatgag aaattgccga tatatacgga aacaggacac cactttttcc ttggagattg 2799661 tttgtatttt aagaatcctg aatttgatcc gcaaaaggcg caatggagag gcgaaaatgt 2799721 gatactactg ggggaagata aatattttgc ccatggtctt ggaatcttaa acggaaagca 2799781 aattattgat aagctgaatt cttttaggaa aaaaggagcc ttacagtcag cctaccttct 2799841 gtctcaggcg accagactgg atgttccgtc tcttttccgc atcgtccgct aaaaagcccc 2799901 atcgcctatt ttccggacga tggggtttca aatgcctttc gttttcgata gaagggggct 2799961 gtgccaaaat attggttcgc agcccactcc attttttcaa ggtcatttct tgtcacgatt 2800021 ggatcctggc tgctccattt gataaagcgg acaaaatagt agcctttgat aggaaccatt 2800081 gtaacttttg agtgaggcca gccttcaaat acaaactcaa ttttccctct ttttttataa 2800141 gaatattgaa gaatgttcat atctgtcacc tcagtttatc aagttacgtt cggcaaagct 2800201 cggtacgttt acatccattg attaactatc cctcatgcag gctttccgga aaacaaaggg 2800261 tgaggcgcgt gtctctttcc ctcgcttttt atttcgcata tggacgaatg ccaagcacgc 2800321 cttcattcga taaagccgca gcgtgggcgg gtgtgacaag ccctccggct atcggcgctt 2800381 gttcagcgat catgcttttg tcataaaaaa cagcctatta tcccatcatt ttgatatagc 2800441 atgtccgggt gcgaggcccg tcaaattcgc agaaataaat gccctgccac gttccaagaa 2800501 taagccggcc gttttccaca atgacatgct gtgaagctcc gaccgtactc gacttcatgt 2800561 gtgcagctgt attgccctcc atatggcggt ccagctcatg ttcccacgga tatacctcat 2800621 caaaccttct gagcatatct tttttgacgt ccggatcggc attttcatta attgtaatgc 2800681 ccgcagtcgt atgcggacag taaatcagcg ctgcgccgct cgttatacct gtttcttgaa 2800741 gaaacgcttc cacctcccgg gtgatatcta tcatttcatc tcgtttggtt gttttgattt 2800801 gcagtgtttt cagcatttgt ttctcctttc gtttgtccgc tctcatcgct taattcgttc 2800861 tgtgttcttt tttttcctgt taaaccgctc tcataaaccc gataaaacaa aaaaactcca 2800921 gtctaaggct ggagtttagc accatagata tattcttgct tcatacggct ttaagagtac 2800981 tgatgtcata tgcttgtgcg gctctgtttc aatatttgac aagacgagtg catctgatga 2801041 caatggcaat ccagagtgcc tgaacaacgc cggtgttcct gtcagattgg ccgcaatcag 2801101 tgcagtatgg ctctcgtttt tccgaagata tgcaaagatt tgctgatctt ccggtaaaat 2801161 gagctcgtat gtcccgttaa taaaaacatc atatgtttgg cgcagcttga tcaagctttt 2801221 gtaaaaatgg taaacggatg ttttatcgtt tttttgcgcc tcggcattca gccatttgta 2801281 attctcattg attccgatcc acggtttggc ctcagaaaat ccggcgtatg gaccagcatt 2801341 ccattgcatc ggcgttcgcg aattgtctct tccctttttc cagacaatct tcatcacatc 2801401 ctcgtgtgat gtgcctttcg ctgtttttgt ttcatacagg cgtttcaatg cgacatcatc 2801461 atagtcctca atagatggaa aagccacgtt cgtcatcccg agttcctgtc cctgataaat 2801521 aaacggtgtg cctttcatga gaaaataaac agcggaaagc gcttttgcac tttctttcag 2801581 gtacactccg tcgtctcccc acacagaaac tgaacggggc tggtcgtgat tctccataaa 2801641 caaagcattc cagccgatcc cttccagact gtcctgccag tcagttaaaa ttcgtttaaa 2801701 tgcaacgata tcaatacttt cattgatctc tacatcccac aggccgagat gctcaaattg 2801761 aaaaatcatg ctgaatatgc cgtttttttc tccagcccaa tcagctgctt cttttgcagc 2801821 gacgccgttt gcttcaccaa ctgtcataat cggatagcgg gaaaatgtgt tttccttcag 2801881 ctctgttaac aaatccataa tgccgtcagc attcatatga taaggaaagg aagggacata 2801941 gtccagtccc tttggattcg gcatgtcagg aaacccttct tttttcttaa tatgcgtaat 2802001 ggcatccacc cgaaatccgt caattccttt atcaagccac caattgatca tgtcataaac 2802061 ggcattcctc accttttcat tttcccaatt caaatcaggc tgttttttat caaaaaggtg 2802121 cagataatac tggcttgtct tttgatcata ctcccaagcc ggcccgccga aaatgctttc 2802181 ccaattgttg ggcgtttttc cgtttttgcc gtctttccaa atataccagt cgcgcttttc 2802241 cgagtgtatg gatgaacggg attctatgaa ccatggatgt tcgtcgcttg tgtggttcac 2802301 aacgagatcc ataatcagct tcatatccag atcatgaatg tcaccaagca gctcatcaaa 2802361 atcttccatc gtgccaaact cgcttaatat gttttgataa tccctgatat catagccatt 2802421 atcggcattc ggtgaatcat acagcgggca aatccatatg acgtcagcgc ccagctcttt 2802481 tatgtaagaa agcttggttc tgattccttg aatatccccg attccgtcgc catttgaatc 2802541 tttaaaactg cgggggtaaa tttggtaaac tacggcttcc ttccaccaag cctttttcat 2802601 acagccactc cttcccagtg taccgttctt atatatccta tgtagaaaaa ggtctttaca 2802661 gcattgcttt ttaagaaatg acttgatgac acaaaaaaca gccgtttgtt ccccggctgt 2802721 tttttatcaa aaatcagttt tttttatttc tacaaaacgg atgtggtgat cttcggcgtc 2802781 gaggatttta aattcacagc cctccgcgtg tatcacatcc cctgctttca gctccatttt 2802841 ttgcgttaga agccagcctg caatcgtatc aatttcttca ttttcaatcg caatgtcgag 2802901 aaggtcattc acttcgtcta ttagcgcttt tccatccatc acataatggt gctcgccctt 2802961 tttcaggatg tgcggtgttt catcctgatc atactcatcg cggatttccc cgacgatttc 2803021 ctcgataata tcctctacag tgacaagccc cgccgttccc ccgtattcat cgacaagaat 2803081 cgccatgtga atccgctcct tctgcatgcg gattaaaagc tgctgaacag gaatgctttc 2803141 aatgactctg ataacgggcc tcatgatttg attcagcttt atcggctggc cgagaaaata 2803201 agctttaaac atatctttgc tgttgatgat ccctaaaata tgatccttgt catctttgat 2803261 gacagggtag cgtgtatacc gttcattaat gatgtgatga attgcctctt caagcgactg 2803321 ctccagagag ataaccgcaa tttctgtccg cggaatcata atctctctcg ctacccggtt 2803381 gtcaaattca aaaatcttat ttacatagcg gaattcagac tgattgattt ctcccttttc 2803441 atagctttca gaaaggatca gccttagttc ctcttcgctg atgacaacct gatgctcctt 2803501 taccgaatga aagccaaaca atttcacaag aaaacttgca gagccgttta atgctttaat 2803561 aaacgggtac gtgattttat aaaaccagat cagcggcttt gcaatccata agcttacagc 2803621 ttcagctttt tgaatagaaa ccgttttcgg ggcaagctcc cccatcacca catgcaaaaa 2803681 agtgacgatg ataaatgcaa ctacaaatgt gacaatgtgg ttaaacggtt ccggtatgcc 2803741 tgtcattgta aataagggat gaagaaaacg ttcaaatgta ggttcaccaa gccacccaag 2803801 gccgagggct gtaatcgtaa tcccgagctg gcaggctgat aaatactcgt caagattgga 2803861 gatgatttta tgtgcggcta gtgctcggct gtcaccgctt tcgatgagct gattgatttt 2803921 tgaacctctg attttgacga tcgcaaattc cgctgcaacg aaaacagccg taatgccaat 2803981 caaaacaaaa atggcgatca attgtaaaat aagcaaaaaa agcccttacc ataaatggta 2804041 aggggccacc tccttaacgt taattctcat cacgaccgtt taagaaaatc atcacaaaac 2804101 gaagtagttc aaacagggaa accagggcgg cggccacata cgttaaggca gcagcactca 2804161 gcactttatt taccccattt tcttcattgt ttcggatgaa tccttctgac acaataatct 2804221 gcttcgcacg tgaacttgca ttgaattcga caggcaatgt aatcagctgg aaaaagacag 2804281 ccgctgaaaa cagtatgatg ccaagcccga tcaaattcag gctgccgaga agcatgcctc 2804341 ctaagaaaag caaaggagct acaccggatg caaaattcac gactgggaag attttatgtc 2804401 tcagcacaag cgcaccatat gactcctgat gctgcaaggc atgtccgact tcatgggaag 2804461 ctacggatat ggcggaaatt gagcggccgt aatagaccgg ctcagataaa cgcaccaccc 2804521 gtcttgtcgg gtcgtaatgg tctgttaaag tgcctcttac cggttcgacc ggcacgtcgt 2804581 aaagaccgtt tatatctaaa atccgtcttg ccgtttctgc ccctgtacgt ccgcttgagg 2804641 cttccacttt tgaatatttt tcaaagttgc tctttacttt aaattgtgcc caaaacgaca 2804701 atcccaatgc ggctattgtt aaaaatataa acagcatttt ttcatcatcc tttgttcatg 2804761 atcatttctc tattacgatt attttaatga gttttctttc tcgtgtacag aaatgcgctt 2804821 tttcttccgg cttggagcac acaatccaat cagcaaaaag aacaggcctg ctgaaaacaa 2804881 ataaaaggcg aaactgccgg ccagttcttt cagaaaatga agccaggaga agcttccgga 2804941 aaagtgatta tatgaattca aatcgaaaat aaacaaaatc accgcggatg ccgccagctg 2805001 cgtaccgatt aaaaccacga tcgttctttg aaagatcgtc atctttttca tcctttttgt 2805061 tttagtttat ggagaaatcc ggttttatat gttttgtaca ttttttgaaa aacatcaccg 2805121 gaagtgggac atactgttag aaaaaagcac gggtgtgatg gaagctatga aagtgacgag 2805181 tgaggaaaag gaacagctga gcacagcaat cgaccgaatg aatgaaggac tggacgcgtt 2805241 tatccagctg tataatgaat cggaaattga tgaaccgctt attcagcttg atgatgatac 2805301 agccgagtta atgaagcagg cccgagatat gtacggccag gaaaagctaa atgagaaatt 2805361 aaatacaatt attaaacaga ttttatccat ctcagtatct gaagaaggag aaaaagaatg 2805421 aaatcaaatc ggatatttat ttcatggctc aggtggccgt tatttatccg aatcggggtt 2805481 attattttat gtctgattct tttgttcggc caaatcattt atatacttga gcctaagcag 2805541 ttcacttcgg tattcgaagg tatttggtgg gctgtcgtta cggtttctac agtcggttat 2805601 ggagactatg tgccgcacac tccgctggga caggcagccg gaatactgct gattttgagc 2805661 ggagcaagct ttgtcacagc gtatttcgct acgttatcag cggccgcatt cagcagacag 2805721 catcgctaca ttgaaggaaa agttgcttac aaaggccggg accacatcat tctgatcggg 2805781 tggaatgaaa aaacaaaccg gcttttgaag gaccttcagc ttgccgcccc ttccaaaaca 2805841 gtcgtactaa tcgatgaatc cttaacagaa ggcccgctta ttgaaaacgt tcatttcata 2805901 cgcgggcacg ctgccgatga tgggacactg aaacgggcca atattactga agcggaatca 2805961 gtgatgatta ctgccgatca gtataaaagt gaaactgatg ctgatatgct gtcagtgctg 2806021 actcttttat ctgttaaagg tcttaatccc cttgcttact gcatcgtcga gattttaact 2806081 gaccgttttg tcaccaatgc ggaacgggca ggcgcaaacc aaatcatcgg aacttcagaa 2806141 tttatcagcc gggcgatgct gcagcattac caagtcaagt tacggccgtc taaacagcag 2806201 aacggaatca agctgacact tgatcagcat gtggagcttc ttgctgttcc tgacgaacta 2806261 aagggagcgg cttacaaaac ctgtgttctc tatttccttg atcacaacac aacaattata 2806321 ggcatacaaa aaaaggaggg gccgatgctt tcccctcctc ttacatacaa ggtgctcgaa 2806381 acagatcaat tccttgccat ctagtgtaac agaacatcct ccaattcttt cacgagagag 2806441 gcgccgatat ccaaaaatgc cggatcaatt tccgcgtccc gcctttccgg ttcggaaaat 2806501 tgattaaaca gtgattggaa aggccctccc tcggcgtgat cgtcaacatc cgcctgaaac 2806561 acctgtctca gcataaatgg cgttccgatc cggacggccg cccctcgttc atcgagactg 2806621 ccctgtaccg cattgacggg aattcttaaa aataaatagc cgtctctatc atcaatttta 2806681 taatcaaagt agccatgatc gtattcccag ccgccgttta tcacataacc gagcggcttc 2806741 atcacttgtt ccagttcttg aagcagaaaa gactgcccat ctatcgcgga aggtattggt 2806801 atcatcagaa tgcccctttt ttcacttatc ctgtcccgcc gaacaagact tcattcagag 2806861 gcgcctacat ggaaatcgtt gtttctttcg cgcggccaac aggaaagaaa gcgcattcaa 2806921 ttaagaagta aacagccatt gccgctgcaa gccatacagc tgaatcccaa gacacataaa 2806981 caaccgttgc atagagtcct aatttagtga aaagagtatg ggttcgtttt aaatgcaaaa 2807041 tccgatgtac cgcatcggta aaaagggcaa gcggcaaacc aatgagaaga aaggagtgga 2807101 tgaaaaaatg tgacagcgtg ccgccaaagc ttgaagaaaa ccctgtatac acggcatcaa 2807161 aggagataag gaaacttaaa atagctgcag aaaaaccggc aatgatgaga tgtttaacca 2807221 attgtttcat gaacatcagc acctttctga ttttataaaa agccgaccgg caaatgccag 2807281 tcagctttct cacattaatc ttccagacgt ttttcaagct ctgctttttt ctcttcaaag 2807341 ccaggtttgc cgagtaacgc aaacatattg actttatacg cttctacacc aggctggtca 2807401 aacggattga cgccaaggag gtaaccgctc atcgcgcagg ctttttcgaa gaaatataca 2807461 aggtatccaa aagtatatgc attcagctca ggaatgttaa cgattaagtt cggaacattt 2807521 ccgtctgtat gggcaagcat tgtaccttgg aatgcttttt tgttaacgaa atcaacagtt 2807581 ttaccggcta aatagttcaa gccgtcaaga tcgttatccg cttcctcaat tgtcagttca 2807641 tgtttaggct tctctacgtt caggaccgtt tcgaataaat ctctgcggcc ttcttgtaca 2807701 tactggccta aagaatgaag gtctgttgaa tagttcgctg aagaaggata aatgcccttc 2807761 tcatctttcc cttcgctttc tccgaacagc tgcttccacc attccgcaaa gtattgaagc 2807821 gccggttcgt agttgatgag catttcaatt gttttgccct tattataaag gacattgcga 2807881 acaaccgcat attggtatgc tgggttatct tccagttcag atgttgcaaa atctttgctc 2807941 gcatccaggg cgcctttcat catgtcgtca atgttgacgc cgctgacagc aatcggcaag 2808001 agacctacag ctgttaaaac tgaataacgg ccgccgacat cgtcaggaat tacgaatgat 2808061 tcaaagcctt cttcgttaga aagcgttttt aatgcgccgc gctctttatc agttgttgca 2808121 taaatccgcg ctttcgcttc ttctttaccg tatttctctt caagaagctt gcggaaaata 2808181 cggaaagcga ttgcaggttc agttgtcgta cctgatttag aaatcacatt aatagagaag 2808241 tcaacatctt caagaagatc catgacgtct ctcatataag atgaactgat gttgttcccg 2808301 ataaaaatga cttgcggatt gccgcgtttt gcttttggca aagtgttata aaacgcgtga 2808361 ttcagcgctt caatcgctgc ccgcgctcca agataagaac cgccgatgcc gacaacaagc 2808421 aagacatcag agtcagattt gattttttcc gcgctttttt tgatgcgcgc gaattcttct 2808481 ttatcataat gttcagggag gtccacccag cctagaaaat cgctgcccgc gcctgttttc 2808541 tcatggatat tatggtgtgc tgtttttaca aagtcccgca ggtatgtaag ttcatgttcg 2808601 ttgaagaaag tcaacgcttt tgagtagtca aagcgtacat gcgtcattgc ttgtccctcc 2808661 ataacggtat aatgttttca tctttcactt tatatgaact tatctgtgaa atcaagtcaa 2808721 gaagaaaggg cggaatgact ggattccgcc ctttgggttt atagagacgc gcgaaggatg 2808781 gcaagcacgt catctttgtt cagtttttgg aagttgccga agccgccgtg ttccatttcc 2808841 ttggctgcga tatcagcaat cagctcaagc ttttcttctc caatattgta atcagcaaga 2808901 cgagaaggtg caccgaggct tgtccagaac gcagacagtt tatcgattcc ttcaagcgca 2808961 atttctttat ctgttttgcc ttcagtatca atgtcaaaca tgttgagcat aaggttttta 2809021 aaacggccta catttgtatc aagcgtgtat ctcatccaat ttgggaacag tattgccaaa 2809081 ccgcccgcgt gcggaatatc atatacagct gaaacagcgt gttccattgt atgagaagcc 2809141 cagtcaccga agtatcccat ttggagcgtg ccgtttaaag caatagtacc agcatacaaa 2809201 atcgtttcac gaagttcgta gttttccaga tcttcaagaa gcttaggagc tgtttcgatg 2809261 accgtctgca aaacagcaaa gcacattcta tcctgaagcg gcgtgttttc aacattatgg 2809321 aagtattgtt cgaatacgtg gctcatcatg tcaaccatgc cgtatactgt ttgattttct 2809381 ggaacggtga acgtattttc agggtctaaa atagagaaac gcggatgagt gacattgctg 2809441 ccccatacaa atttctcgtt tgtttcccag tttgtaatca cggaatcagg gttcatttca 2809501 gaccctgttg cagcaagagt taaaacagtg ccaaacggca gcgcatcctc cgctgttact 2809561 tttttgctga aaatatccca agcgtcaccg tcatatttga cgccagctgc gattgccttt 2809621 gtacagtcaa tcacactgcc tccgccgaca gcaagcagaa aatcaatgtc atgctctctg 2809681 caaagtccta tgcctttttc cactgtcgca agacgcgggt ttggctctac acctgacagc 2809741 tcatgaacaa cagcgccctc ttcttttaaa atgcctgtga cttgatcata aaggccgttg 2809801 cgtttaatgc tgccgccccc gtaaacaagc agtacattct tgccgtatcg tttgaattct 2809861 tttcttaatt gttcaagctg accttttcca aaaatcagct ttgtcggatt ataataagtg 2809921 aaattttcca tagtaaaacc tccaaatgat gctggtaaaa aacagatttt ccattgtaac 2809981 ataagttgac aaaaaagaaa aagggaagca gccaaacggc tatttcccct ttttttatag 2810041 tgatgctttc aaaattgaca gcacatcttc tttgttgagt gatttaaatt ggccgaatgt 2810101 accgttagcc attgccttgt cagcgattgt gtcaagctgc tcatcattaa tatcataatc 2810161 agcaagacgg ttcggagcgc caagacttgt ccagaatgcg gacagcttat cgataccttc 2810221 aagggcaatt tcttcatccg ttttacctgc ttcttcaaca tcaaacacgc gaactgcaag 2810281 ctgtttcatg cgggcagggt tttcagacaa tgtgtgtctc atccaattcg ggaacagaat 2810341 cgccagtccg ccggcatgcg gaatatcata aacggctgat actgcatgtt caatattatg 2810401 agtagcccaa tcccctcttg cccccataga aagcatgccg tttaatgcga ttgttcctgt 2810461 gtacaggatc gtctcacgca attcgtaatt ttcgagatca ttgatcagct taggcgctgt 2810521 ttcaatgact gtacgcaaaa gtgattcaca catgcggtcc tgatacggcg tgtttgatac 2810581 atgatggaag tattgttcga atacgtggct catcatgtca accatcccgt agatcgtgtg 2810641 gtttttaggt acggtgaatg tattcaccgg atcaagaatc gagaatttag ggaatacgag 2810701 cgggctgccc cagccgtatt tttcttttgt ttcccagttt gtaataacag atcctgagtt 2810761 catttctgaa ccagttgcag cgagagtcaa taccgttccg aatggcaaag catcttttgg 2810821 ctgatgcttt ttcgtaacga tatcccacgc atcaccatca tacttcgctc ctgcggcaat 2810881 cgcttttgta cagtcgatta cgcttccgcc tccgacagcc agcaagaaat caatgttttg 2810941 ttctttacag atggcaacac ctttattaac agtcgacaca cgaggattcg gttccacacc 2811001 tgctaattca tgcacggtcg ctccggcttt attcagctgt tcaatcactt gatcatacag 2811061 gccgctgcgt ttaatgctgc cgcctccgta cacaagcaat acgttttttc cgtaaggttt 2811121 gagttcctcc ggaagtcttt ccacttcgcc gcgcccgaaa attaatttgg tcggattcca 2811181 gtatgtaaag ttttgcatga catctcctcc ttagattttt tattatgcag aatgtcctca 2811241 ccacatgtaa agcaatcagc tctcaccgat cagcatacca gatggtttta ttttgcaagg 2811301 tgctgggaaa gaagctgata taagcgaggg caggccagct tccctcatat ggagaatgca 2811361 tgtatagatt ctccaatatg tcacaatcta taactgtttt aataattcat ggaggaggtt 2811421 gcaaaacatg agtaccattc aaagaatttg tcttgtatta accatcattg gcgccattaa 2811481 ctggggactg atcggatttt tccaatttga cttagtagcg gctatcttcg gcggccaagg 2811541 gtcagctctt tcccgaatca tttacggact tgtcggaatc gccggcttaa tcaacctcgg 2811601 tctgctattt aagccaaacg aggaaagatc acgtgaagaa gcagcaaatc ctgaaatgcg 2811661 ataggatatc aatcacgctg aaataggatt ttgcatgaaa tcaaaagcac cgaacattcc 2811721 tgtccggtgc ttttttcatg cttatttttt gataaggtct ttgcggttgg acatttcgat 2811781 ccactcttca agcttatctt ttaatgtgtt gaaaccttgt ggtgtagaag cttcttcgct 2811841 tacttgagca gctttaggtt ttcttggttt gctttctttt ttctcaggcg cagcttgtgt 2811901 cgcacgaatt gaaaggctga ttttgccttt ttcttcatca acagcaagta cttttacttg 2811961 tacttcgtcg ccaactgaaa ggtgctcgtt gatatctttt acgaaaccgt gagtcacttc 2812021 agaaatgtgt actaaacctt gagtttcttc atctaatgca acaaacgcac catacgcttg 2812081 taatcctgta actttaccag tgtaaacact gcccacttca aattttgctg ccattcataa 2812141 caactcctaa gttaaattaa atatctgttt atacgcaatt taaaattata tcacacatgt 2812201 cttatttccg caaagaaaac ttttttataa aaaatcaggt ttatgcacag caaaaagggg 2812261 gtaaactgaa aataccaaag gctttctagt attcccccct tttattggat gcgaacaaaa 2812321 ggttcgtatc tttttttatg ttgttttgtg caggaagcgt ttcattctga ctaacgcttc 2812381 ttgaagctgt tcaatcgagg ttgcgtatga acaacggata tatccctcac cgctcggacc 2812441 aaacacactt ccaggaacaa ctgccacttt ttcctgcgtc agtagctcct cggcaaactg 2812501 ttctgaactc attcccatgc ttttgataga tggaaaagca tagaaagcgc cgcccggatg 2812561 atgacagctg agaccgattt cattgagcga ttctacaaac agattccgtc ttcttcgata 2812621 gctttttttc attttttcta cgtcttccat gccgttcttc aggccttcaa gggcggcaaa 2812681 ctgcgccatt gcgggcgcgc acatcatcgc atactgatga attttaagca tggcatcccg 2812741 aagcaaggat ggtgccgcgg caaaaccgag cctccagccc gtcattgcaa atgcttttga 2812801 aaagcctgag atgactaccg tccgttcctt cattcccggt aatgccgcta tacttgtaaa 2812861 ttcctcatca tatgtcagct ccgcgtagat ctcgtcggct aagacgatga catcatgttt 2812921 tttggcaaac tcagcaatct cattcagctc ttccttcgaa taaaccgaac ctgtcggatt 2812981 cgatggtgag cagatgagaa tggcctttgt tttttcagtg actgccgctt caaaatcagc 2813041 agccgttgct ttaaatcctt tgtctgccgt tgtatgaacg tgaaccggga taccgcctgc 2813101 caaagaaaca agcgcatcgt acgcaacaaa acacggctca ggaatgatga cttcctcacc 2813161 tggattcaca atggcgcgga tcgcaatatc caaagcctga cttgccccca ctgtcacaat 2813221 cagctcatta tctggcgagt agctaaggtc aaacctgttg ctcaaataac ggctgatttc 2813281 ctcccgcaat gagtataaac ccgcattggc cgtgtatgac gtatatcctt gttcaagaga 2813341 gagaatgctt gcttcgcgga cattccatgc ggtaacaaaa tcaggctcgc cgacgcctaa 2813401 agaaatgacg ccttccatcg ttgccgccaa atcaaagaat ttgcggatgc cggatggttt 2813461 tatttgttgt acatagtctg ataaatacga agtcatttac ggtgacacca cgattctttt 2813521 gtcgtcgtct cctgtttcaa acactttgcc gtcatgcttg tattttttca ggataaaatg 2813581 ggttgtcgta gatacaactg aatcaagcgt tgagagttta tccgaaacaa aacgcgctac 2813641 gtcagacatc gaattgccgc gaatcacgac agacaaatcg tatacgcctg acatcaggta 2813701 aactgattca acctcttgga atcggtaaat ccgttccgcc acttcatcaa aaccgacgcc 2813761 ccgcttcggc gttactttga cgtcaatcat ggccgtaacg ccctcatgtc cgtcgacttt 2813821 tcgccagtca atcatagcgg aataatcgat aataaccttt tctttctcca gtttgtcaat 2813881 aattgttttc acttcattta cagggatgcc cgccatcttt gcgattgttt ctaaatcggc 2813941 gcggctgttt tcgtctaaaa tttctaatat ttctgtttct ttttctgtca atttcatttg 2814001 attcacacct ttgcaatgtc aagaaatctc atgacattat atcacgtttt ttgacgaatg 2814061 ctaagaaaaa acgaggagaa acttccgcta gaattgacaa tttcagggca taatacaacc 2814121 atcaaaaaaa gggagtgaca cagaatggag gcggtttcac caataaggcg gtttacggtc 2814181 gatggagtca atgtatacta cgaacattat caaaatcccg gcaggcaaac gctggtctgc 2814241 gtacacggtt ttttatcatc tgcattcagc ttcagaaaag taattcctct ccttcgggac 2814301 aagtacgaca tcatcgcgct tgatttgcct cctttcggcc aatctgaaaa atcaagaacg 2814361 tttatctata cctatcaaaa ccttgctaag cttgtcattg ggattttgga gcacttgcaa 2814421 gtgaaacagg ctgtgcttgt cgggcattct atgggcgggc agatatcgct gtctgctgct 2814481 ctccaaaaac ctgagctttt ttcaaaggtt gtgctgcttt gcagttcagg gtatttaaaa 2814541 cgttcacacc cgacgattat tttcgggacc catatcccgt attttcatct ttacatcaaa 2814601 cgctggctct cgaaagaagg cgtgatgaaa aatttattaa atgtggtgca tgacaaatcg 2814661 ctgattgatg aggagatgat tgacggctat ggcagaccgt ttcaggacga gcagattttc 2814721 aaagccatga caaggtttat ccgccacaga gaaggagatt tagaacccga gcaattgaag 2814781 aaaatgaaca agcctgctct attgatttgg ggcgaggagg atcgaattgt cccaatggag 2814841 atcggtaaac ggctgcacgc agatttgcct aattccgtgc tgtactcact tggccagacc 2814901 ggacatctgg tgcctgaaga acggcctgaa cttatttctg aacacattgc tgattttatc 2814961 aaataacaaa aaaaccggtg ctgaaccggt ttttttaagg cgtgcaggag ctgctgtttt 2815021 taatgaataa aagctggcca gccacttccc ggcagctggc gatcggcagc gtttgttcaa 2815081 aagaagtttc aaatatttgc tgaatgcttt tcgccagcaa gtcgggatcg ttttcatcat 2815141 agactgcctg cacgacatca acagcctccg tttcgtaaaa ctcttctcca tatttaaacg 2815201 ggtcccattt ggcaatgatc ttaatcattt ccctgaccgc atgactttct tccatattca 2815261 tcaccgctta taataaaatt tgcagttcta tcttatcata gtgaagctta gaagaataaa 2815321 catacatgag ggggtaacag aatgaacttt gataaacgag aagaacgcct tggcacccaa 2815381 tcggtcaaat gggataaaac aggcgaatta tttggcgtga cagacgccct cccgatgtgg 2815441 gtggcagata tggattttcg cgccccggaa gcgataactg aagcgttaaa agagcgtctt 2815501 gaccacggta tttttggtta tacaactcca gatcaaaaaa cgaaggatgc tgtgtgcgga 2815561 tggatgcaaa acaggcacgg ctggaaggta aatccggaaa gcatcacatt cagccccggc 2815621 gttgtaacag ctttgagcat ggcggtacaa gcttttacgg agccgggcga tcaagtagtt 2815681 gttcagcctc cagtttatac gcctttttac catatggtgg agaaaaacgg ccggcacatt 2815741 ttacataatc cgctgctaga aaaagacggc gcatatgcaa tcgattttga agatttggag 2815801 acaaagctta gtgacccaag cgttacattg tttattttat gcaatcctca taacccttct 2815861 gggcgttcat ggagccggga agatttactg aagctaggcg aattgtgcct tgagcatggc 2815921 gtcacagttg tatcggatga aatccattcc gatttaatgc tgtacggaca taaacacacg 2815981 ccgttcgctt cgctctctga cgatttcgct gatatttccg tgacatgtgc tgctccaagc 2816041 aaaacattta atatcgccgg attgcaggct tcagcgatca ttattccgga tcgcctgaag 2816101 cgcgccaagt tttccgcaag ccttcagcga aatggtttag gcggactgaa cgcgtttgcc 2816161 gtcactgcaa tcgaagccgc gtattcaaaa ggcggaccgt ggcttgatga attgatcact 2816221 tacattgaga aaaacatgaa cgaagcggaa gcctttttga gcaccgagct gccaaaggtc 2816281 aaaatgatga agccggatgc atcatacttg atttggctcg acttcagcgc ttacggcttg 2816341 tccgatgcag agcttcagca aagaatgcta aaaaaaggaa aagttatttt agagcccggg 2816401 acgaaatacg ggcctggcgg agaaggattt atgcgcctga acgccggatg ctctcttgca 2816461 accctgcagg acggcctgcg ccgcatcaaa gccgcattat cgtaaatata gctgtaaacg 2816521 cctttacgtc ttcatttgta aaggcgttct taataaagga attttatatt ttacttctaa 2816581 tatttagtgt tataatagat tcatatttta tacgaaagga tttcacacga atggaaattc 2816641 taaaagacta tcttctgcac atctgcttta ttttgtttcc tattcttctt taccaagtgt 2816701 tttggcttgg aaaacctgcg attcttgtgc caaaaataaa cagcggtttg gtcacgctct 2816761 tcgcctgcgg cgcctccgtt ttatgcatta ttttcccgat tcatgaaatg gactacatac 2816821 aatacggcct tcagatgatt cccgttatca tttgtttatt ttacattagt accgcttccg 2816881 gacttacagt cgccgcatct gtcctatgtt ttgaactgct tttttacgaa ccttccgcaa 2816941 tgtttgtttt cactttgctg ccttttctta tcattatccc aatcttattt cagaaaaaat 2817001 ggccattcat gtccaaagcg aaaaaactgc tgctgtcttt attgatcagc tgcgtggaga 2817061 ttttcctatt tttcgcctca agctggattc tttccgcctt gaatatttta aattttcaaa 2817121 aatcaggaat tttcgtttac gaggcggcag tctcagggct tttccgctcc agtgttcttc 2817181 tattaagcat ctatattatc gaaagcatcg ccgaaaatat cgccctgcgt tcacagctta 2817241 tccattctga aaaaatgacg attgtgagtg aactggcagc gagcgtcgcc catgaggtca 2817301 ggaatccgct gacagttgtc cgcgggtttg tccagctgct ttttaatgac gaaaccctac 2817361 aaaacaagtc gagtgcggat tacaaaaagc ttgtactgtc agagcttgac cgggcgcaag 2817421 gcattatcac aaactatctc gatatggcca aacagcaatt atacgaaaaa gaggtttttg 2817481 acctatctgc ccttatcaaa gagacaagct cccttatggt gtcgtacgcc aattacaagt 2817541 cagtaaccgt cgaggctgaa acagaaccgg accttttgat atacggagac gcaacaaagc 2817601 tgaagcaggc tgtcatcaac ctgatgaaaa acagtattga agcggttcct cacgggaagg 2817661 ggatgatcca catatcagcc aaaagaaacg gccatacgat catgattaac atcacagaca 2817721 atggggtcgg gatgacagac catcaaatgc aaaaactcgg cgaaccttat tattccttaa 2817781 aaacgaacgg aacgggactc ggcctcaccg taaccttttc cattattgaa catcatcacg 2817841 ggaccatttc atttaacagc agcttccaaa aaggcactac ggtgaccatt aagcttcccg 2817901 ctgatcttcc tcactagcaa atcgattgga actttaatag aataaatgcg aggtgatgac 2817961 agatgagcac gtttgagaca ggctctatcg ttaaaggatt ttacaaaaca ggtgtataca 2818021 taggagaaat cacggcttgc aggccgcagc attatttagt gaaagtgaaa gcggttctta 2818081 cccatcccgc tcagggagac cttcatcatc caaaacaggc ggatgtgcca ttttttcatg 2818141 agagaaaagc gctcgcatat ggtgaacaga ccaatatccc ccaccatatg gtgaagcctt 2818201 atgacggtga agtgccggat tataccgaat ctctgcggga ggcgacagca cagatgagag 2818261 ccaaattgaa tgaggatggt tcggagtggg caaagcgctc ccttcataat ctggacattt 2818321 tagaaaaaga atattttaac cggccataac ccagtctgac aaaagattgg gttttttacg 2818381 tcgcgcgctt caacagttcg gttaaatcga ttctctcgcc gattgtgggc ggttttggct 2818441 tttcgagata ctgcttatcc tgctcaacaa gcttaaaaag tttatatgct gtgagagcat 2818501 catcaagcgc tttatgatgg gtgccggttc cggaatctcc atactcttcg gcagctttcc 2818561 ataaacccgt caatgtccgg tctccaaaaa agtttttgta ttcaagcgat aaatctctca 2818621 tttctccctt aaacgggaaa gggatatggt taaacataca gttttgcttc agcactttca 2818681 tatccatgtt tccccacgta ataattgtgc tgtttttctc aggatccagc tcgtttagtt 2818741 tacggatgaa atcctcgaat ctcattcctt cgtctacctg tttttgggtt atttttaaaa 2818801 atgatttgca gcgtttcgta agcttcggga actttttcgg tctaacatag ctagaaaacg 2818861 tctcaaccac ttcatcatca atcgacttta caattccggc ttcaatgatt tccgggaaga 2818921 agttttgagg actgtacttt ccatcaggca ttgtaaattc gaaatcaata atgagtaagc 2818981 tgtttgtcgt caccttttac acctgccttt cctccgatca gaaaatgcta tctttatagt 2819041 atatcaattc cccttctcga catttcttca ttttctaaaa ataatgaatt ttcccagccg 2819101 cttcgtttct tttaaattgt gaatcgtttc tttataatta gtaaggaacc cgaaataata 2819161 agaaggtgat gttatttcta tccgtaagaa aaactttgtc attgtgtggc tggcgaactt 2819221 ttttgtctcc gctagcacaa cgatgatcgt tccttttctc tccttataca ttgagacgct 2819281 cagctctttt tcaaacggct ttgtgcaaag gtggagcggc tatgtgttcg gcattacatt 2819341 tctcatggcg tttttggtat ccccgttttg gggacggttc ggagacaaac gcggatacaa 2819401 gaaaatcctt atggcaaccg gaacaggcat tgccctcagc attttcttca tgggctttgt 2819461 tacatcggtg taccaattgt tttttctgcg tatggcaatg ggtcttgtaa ccggattcat 2819521 cccgacatct cttgcgatga tttcggcaca gactccgaag agctcagctg gcaaaacact 2819581 cggcacgctg caaatggggc aagtgtccgg aagcttgttc ggcccgcttt tgggaggcat 2819641 gcttgctgat cgtttcggct ttacgtatac cttttttatc acatcctttg tgattttctc 2819701 gtctgttctt ctcgtgttat ttggtgtcaa agaaaagcat cttgcagaga aaacagccaa 2819761 acgtacgtct tactcgagaa aagaagtgct ctcctatatt tttcaccatc cggcgctgtg 2819821 ggtcatgatg ctgttaacca tgctgattca aacaggcaat ttcagtatcc agcccctgct 2819881 cgctttatat gtaaatgagc tgcacggacc tgtcaatctt gcctttttct ccggcatggc 2819941 attttcagca acggggctcg gaagtttgct gctggctaga aaatggggtg atctgggcga 2820001 ccgctacggc caccgccgca ttttaatcgg acttttgctc gccgcctctt tcttttttat 2820061 tccgcaggcg ctcgcgtcct cactcagcgt gctccttgtt ttcagatttt tattcggaat 2820121 ggcgatgggc ggtttgctgc catgcattac ggcagcgatc cgcgttcagg ctcccggcag 2820181 cattcaaggt gaagttctcg gctacaatgt cagctttcgc tttttaggaa acgtgctcgg 2820241 gcctctgctc ggcggaatca tatcgagcca ttttaccatt tcggccacct tttacgtcac 2820301 ggcgtttctc tttttcgccg gcgcctgcat gctttggatc atgcagaaac ttcggaaaga 2820361 ttcttatgcc aaagcaagct gattccgaga aaaaactaag gaatcttcta aatttaacct 2820421 tctcgtaatc tcaaaagaat ggtacgatat ggctagaatt taggagaaaa gagagtgacc 2820481 atgttacgaa aaataatcgg atggattttg ctcctttgca taatcccatt gtttgcattt 2820541 acagttatcg cttccggaaa agaagtaaaa caaatgaagt ccctggatca ggtgcttgat 2820601 aaaaatattg atctgaaaga tatcagcctt gttcagaaca gctacatgta tgacagggac 2820661 ggctcccttg tctcggaaat cgtcagcgac cacgaaaacc gtgtgctcgt tccatttaac 2820721 aagattcccg aggaagtcaa acagattttc ttaacatctg aggaccgcca tttttacgag 2820781 cataaaggct ttgactttat gggaatggtg cgggctactg cttctaacgt aaaagacaag 2820841 aaaattgacc agggtgccag caccatcaca cagcagcttt caagaaactt gtatttgagc 2820901 cacgaacgct ccttcagccg caagctgaca gagctcgcgt attcctatca gctggagaaa 2820961 aaatatacga aaaatgaaat tcttgaagct tacttaaata ccatttattt caacaacggt 2821021 gtttacggcg tcggttcagc agctcaattc tatttcagca aaccgctgaa atctctcaca 2821081 gtgggagaaa tggcttttat ctgtgctata cctaataacc ctacattata tgatcctctc 2821141 aagcattttg actacacgaa aagccgtcaa gaacgtttac ttaaagggct aaaagatgcc 2821201 ggggtcatta cggacaaaga gctgaaaaaa gccgtaaaac aaaaaatcaa actggatgtt 2821261 gaaaaaagag aagacaaata tcctgactac gtttcctacg tcaatgatga attcactcag 2821321 ctggtgtctg aatcagaagg ctttgataaa cgccttcaaa aagcatcagg aaaacaaaaa 2821381 gaaaagatcg agaacgagct gtccgcaaga gtcagcacgc tgatgaaaga cggagtgaaa 2821441 atttatactg cacttgatcc gtacatgcaa aatcaagttg tggcacaaat gaattccaag 2821501 ctcccgtatg cggacgtaca gggcggagcg gctgtgatta atcaccagac gcatcaaatc 2821561 attgctctat ccggcgggaa aaactatcaa aaatatgact ttaaccgcgc ctaccaggcg 2821621 tacaggcagc cgggttcatc cattaagccg cttcttgatt acggccctta tattgaacag 2821681 accggcgcga caacaagcag caccattgat gccagcaagt tttgcagcaa agactactgt 2821741 ccgcaaaact acaataaccg cacttacggc acagtgacgc ttgatacggc gtttaaaaat 2821801 tcatataata ccccggctat tagaatgctc gaccgcgtcg gcatccaaaa ggcattcagt 2821861 tatattgagc cgtatcattt tgccaaactt gtcgacagtg actatcttct tccggcggcg 2821921 cttggcggat ttacaaacgg catgacgcct cttgagatga caaaggctta tacgacattc 2821981 ggaaacagcg gaagctatac gccgagccat gcgattacaa aggtgacaga ccttaaagga 2822041 aaaacacttt ataaatggaa tgataaagcg actcaaatat tcagcgtccg cacgaacatg 2822101 cagctgaaaa aactgatgtc ttccgttgtg aaaagcggaa cagggaaaaa agcatatttc 2822161 aatgcgcctt acatcggcgg taaaaccgga acatcaaatg attatcacga tatgtggttt 2822221 gtcggcctga ctgatacgta tacaatgggt gtctgggtcg gaaaggatac accgaccagc 2822281 gttgaatatc ttcacagcat cagccctcag ctttccatct ggaaaggaac gctgcaagcg 2822341 gcttattaaa ggatcggagg ggatatggag tgacttcaga acaaattcca aatcgcgttt 2822401 tgctgtttga cggtgtctgc aatttatgca atggcgccgt gcagtttatc attaaacgtg 2822461 atccggacgg attgatttct ttcacatcgc tgcagtcgga aacaggacag agcctgctga 2822521 aaaaaagcgg gcttccgact gatcggtttg acagctttgt ctttattgaa gacggccaag 2822581 tgtacacaaa gtcaactgca gccattaagg ttttcaggca tctgcgaggc ccatggcggc 2822641 tcttcgtcct ttttttcgca gtgccgaagc ctgtcagaga tatggtctat tctttcattg 2822701 ccaaaaaccg ctataagtgg tttggcaaaa aaaatgaatg tatgctcccc tccccttcca 2822761 ttaaaaaaag atttttaccg taaataaaaa atggctagga agctagccat cacagattgt 2822821 tgacaaaatc ctaaaacggc ttcgttttag gattttgtca tctattcagc gtgattgaaa 2822881 acttttgaag ttgtgaaacg gcggaaacct gagaatctag ccgccgtttc attgcgtaca 2822941 gagcacgaag cgcaaatctg accaccaaac gctgaaatgg ctagcttaca caggtaagct 2823001 agccattatg ctattataaa gcttgataaa tatgaacaga ataccgataa caaaggtaaa 2823061 ccaaaacagc agttccaata gaatgaatcc aactaatgac atgagagaaa gcgtcgaata 2823121 aatccggtat acggtaaaca caaagtaagc gagcgtgacg accgcaaacc agatcacaat 2823181 ccaaatgaca ttttgcaaga gcacaaagga taaaatcccg ccgcccaaat aaatcatgga 2823241 acccattctg agttttttca ggttgttccc ttccggatca ttagcaaaaa acagcaatga 2823301 cagctcggtc acggtatttg caattaattt cagagcggac agaaccataa aatataaaag 2823361 tgcaaaggca gcaaataacg caagcctgat tcctttctct gaaaaataat cgagcattcc 2823421 atcatacatt ccaaatgaag acagcatctt caacgcataa agtgaagttg agatggataa 2823481 ggacgaacta aaaagcagga tcgcaatcag cggaaaatat cctgtcaaat aagtattttt 2823541 catataaaaa agtccctttc tataatctac ctcatttatt atggaggact taaaacacat 2823601 tgacaagata aattattcca ttttttctcc tttttacgaa ttacgggccc aaatcttcac 2823661 aaagcagcat tttgagagta aagtagtacg caggaatcat aaaacgtaag gaagttttat 2823721 atgaaaaaaa cattaaaact gcaaaccaga ctcaccatat ttgtttgtat cgttgtatta 2823781 atcgcattgc tcattacgtt ttttacagtc ggtgcccaaa ccaccaaacg aattagagat 2823841 caggaaaagg ccactgcgct gcagactgct gaaatggtag ctgaagcgcc gatgacagcc 2823901 gctgctttag aaagcggaaa aaaacaaaag gaactgcaga gctacacaaa gcgggttcag 2823961 aaaattaccg gcacggaatt tgttgtcgtc atggatatga acggtatccg caaaactcat 2824021 cctgacccga gcaaaatcgg aaaaaaattc agaggcggtg atgagtccga ggtattaaaa 2824081 gggcatgtcc atatcagcac agcctctggc acgctcggga aatcgcagag agcgttcgtc 2824141 cctgtctacg cggagaatgg aaaacaggtc ggtgcagtcg cggtcggcat caccgtaaat 2824201 gaaattgatg aagtgatcag ccatagctta cggccgcttt actttattat ttgcgtcagc 2824261 atcttcgtcg gtgtgatcgg agccgttatc gtcgcccgta cagtgaaaaa tatcatgtac 2824321 ggacttgaac cttatgaaat tgcgactctg cttgaagaac ggagcgcgat gctggaatcg 2824381 acgaaggaag gaatactcgc tgtcgatgaa catggcaaaa ttaaacttgc caacgcggaa 2824441 gcaaaacgcc tattcgtcaa aatgggcatc aacacaaatc ccattgatca ggatgtagat 2824501 gacatcttgc cgaaaagccg cttgaaaaag gtcattgaga caaaaaaacc tcttcaagac 2824561 agagacgtcc gcattaacgg gctggagctt gtgtttaatg aagttcctat ccagctgaaa 2824621 ggacaaactg tcggagcgat tgcaacattc cgcgacaaga ccgaggtaaa acatttagct 2824681 gaacagcttt ccggtgttaa aatgtatgca aacgcactga gagcgcagtc tcatgaattt 2824741 atgaacaaac tgcatgtgat attaggtctc gtccagctga aagagtatga tgatcttgga 2824801 gattatatta aagatatagc catacagcaa aaatcagaaa caagtgaaat tataaatgat 2824861 gtcaaaagct ccgtactggc cggttttctg cttggaaagc aaagctttat acgtgagcag 2824921 ggcgcaaatc ttgatattga atgcaacggt gtcatcccga acgcggcaga cccttctgtc 2824981 atccatgaac ttattacaat catcggaaat ctcatcaaca atggcttaga tgccgttgcc 2825041 gatatgccga aaaaacaaat caccatgtcc atgcgcttcc ataacagcat acttgatatt 2825101 gaaattaccg atactggagc aggcatgtct gaagaagacc aagccaaagt atttgaacaa 2825161 ggctattcaa caaagggcaa aaaccgggga ttcggccttt atttcacaca gcaaagcatc 2825221 gaaaatttaa aaggccaaat gatcctcaca agcgaaaaga atgaaggaac gacattcagt 2825281 attcgcatcc cgtacgaacc gaaggaggaa aatcatgatt aatgtactaa tagttgaaga 2825341 tgaccccatg gtgggtgaat taaataaacg atacttaagc caaatagatg gctttcagct 2825401 gaaaggcatc gcttcttcct ttcaaagcgc tctgcatatt ttaggggagc accatattga 2825461 cctcattttg cttgatattt atatgccggg aaaaaacggg ctggaactgc tgacggaatt 2825521 gagagcccaa aatgaagcgg ttgacgtgat tgtcatctca gcggccagcg agcttgacgt 2825581 gatcaagaaa acacttcggt acggagctgt tgattattta atcaaaccgt ttgaatttga 2825641 acgattccaa acggctctgt ctgattacag acgaaaacaa aaggtgtatt caacccatcg 2825701 caacatgagc caaaaagaac tggacgccga gctttttcaa aagaaagaag caacagaaaa 2825761 agtgcagctt cctaaaggcc tgacaaaaag cacgctgaag ctgatctggt ccagtatcca 2825821 gtcatttgaa aatgaatctt ttacgacaga agacttggca aagcacacag aaatctctca 2825881 agtatccata cgaaaatact taaagtttct tgaagatata caggttctga atgtagaaat 2825941 ggcgtacgga acgatcggaa gacctgtgtt tcagtacaac gtcaacaaca gtaacattaa 2826001 cggaataaag caatatctat aagaaaacgc actgcttgct ttgagcagtg cgtttttctg 2826061 tcatatctct tgccaagatg cttgattcta ttgttgataa gttatacaag aataacaaag 2826121 ggctttcaca tttttaagca aataattcta aaaatagata atttttaaaa aattatgcga 2826181 aattctattt atttcttatt agttaaatga taaattatga ttggttagtt gatcccgaaa 2826241 aactaagtca taagtcttac ttcagaaaac gatgtcacgg ttttccgccc ggaacgcctt 2826301 ccgcatcctt ctcttccccg cctttcgaag gaaatactca caccacgctt attcagggaa 2826361 gaatagaact gtctcagcgc attccatttg ttattatcag aaaattttat cgattctaag 2826421 aaattgttca ggacagccca tcacatgact ggccggatca gctttgaacc aaatttttct 2826481 ggggggttat atcttgaata aacgaaaaat cggattggcg atgtcacttg tgatcgcagc 2826541 aggcaccata ttaggagcat gcggaaacag cgaaaaaagc agcggctcag gcgaaggcaa 2826601 aaacaaattc agtgtggcga tggttactga cgtaggcgga gtggatgaca aatccttcaa 2826661 ccaatcagcc tgggaaggca tccaagcctt tgggaaagag aatgggctga aaaaaggcaa 2826721 aaacggttac gactatcttc aatccaaatc tgatgcagac tatacaacga acttaaataa 2826781 attggcgcgt gagaattttg acttaattta cggcgtcggc tacttaatgg aggattcaat 2826841 cagcgaaatt gctgaccagc gtaaaaatac aaactttgcg attatagatg ctgttgtcga 2826901 taaagacaac gtcgcaagta ttacgtttaa agagcaggaa ggctcatttc tcgtcggagt 2826961 ggccgcagcc ctatcaagca aatcaggaaa aatcggcttt gtaggcggca tggaatcaga 2827021 gttgatcaaa aaattcgagg tcggcttccg tgccggcgtg caagcagtta accctaaagc 2827081 cgttgtagaa gtgaaatacg cagggggttt cgataaagcc gatgtcggta aagcaaccgc 2827141 cgaaagcatg tataaatcag gcgtagatgt tatttatcac tctgcgggcg ccactggcac 2827201 aggcgtcttt actgaagcga aaaacctgaa aaaagaagat ccaaaacgcg atgtctgggt 2827261 catcggtgtc gataaagacc aatacgcaga aggccaggta gaaggaacag atgataacgt 2827321 caccctcact tccatggtga aaaaagtaga tacagtcgtt gaagatgtaa cgaaaaaagc 2827381 gagtgacgga aagttcccgg gcggcgaaac acttacctac gggcttgatc aagacggagt 2827441 cggcatttct ccatctaaac aaaatctatc ggatgatgtg atcaaagcgg tcgataaatg 2827501 gaagaaaaaa atcatcgacg gattggaaat cccggcaact gagaaagagc tgaaaacctt 2827561 caaagctgaa taagaatcgc agggataagg aggtcgagcc cttatccctt gtttttcttt 2827621 tattttgaaa taaaggagcg gtcaatcaat ggaatatgtc attgaaatgc tcaatatccg 2827681 caaggcgttt ccaggtatcg tcgccaatga caatatcaat cttcaagtca aaaaaggcga 2827741 aatacacgcg ttgctcggtg aaaacggagc ggggaaatca acattgatga atgtcctttt 2827801 cgggctgtat cagccggagc ggggtgaaat tcgggtgcgc ggcgagaagg tgcacatcaa 2827861 cagcccgaac aaagcgaatg accttggaat tggaatggtg caccagcact ttatgcttgt 2827921 tgacaccttt acagttgctg aaaatattat tctcgggaag gagccaaaga agtttggcag 2827981 aattgaccgg aagcgtgctg gccaagaggt gcaggacatt tccgatcgat acggcctgca 2828041 gatccatcct gaagcaaaag cagctgacat atcagtcggt atgcagcagc gcgcagaaat 2828101 attaaaaacc ctctaccgcg gtgccgacat tctgattttt gatgaaccga cggctgtttt 2828161 gacgcctcat gaaattaagg aactgatgca aattatgaag aacctggtca aagaagggaa 2828221 gtccatcatc ttaatcaccc ataagctgaa agagattatg gagatttgtg accgcgttac 2828281 ggttatccgt aaaggaaaag gcatcaaaac ccttgatgtc cgtgatacaa accaagacga 2828341 actcgccagt ctaatggtcg gccgtgaggt atcgttcaaa actgaaaaga gagctgctca 2828401 gccgggagcg gaagtgcttg cgattgacgg cataactgta aaggataccc gcggaataga 2828461 gacagtcaga gatttgtctc tttctgtcaa agcgggagaa atagtcggca tagcaggcgt 2828521 cgacggaaac gggcaatctg agctgatcga agcggtgaca ggactccgca aaacagattc 2828581 aggaacaatc accttaaacg gaaaacagat ccaaaacctg acgccaagaa aaatcactga 2828641 atccgggatc gggcatattc ctcaggatcg ccataaacac ggtctcgtcc ttgattttcc 2828701 aatcggagag aatatcctgc tgcaaagcta ttacaaaaag ccgtattcag cattgggcgt 2828761 tttacataaa ggcgaaatgt acaaaaaagc acgcagcctg atcactgagt acgatgtcag 2828821 aacgccggat gaatatacac acgctcgggc attgtcaggc ggaaaccagc aaaaagcgat 2828881 tatcgggcgg gaaatagacc gaaatcctga tttattaatt gccgcccagc cgactcgcgg 2828941 ccttgatgtc ggagcgattg aatttgtcca taaaaagctc attgagcagc gtgatgccgg 2829001 gaaagccgtt cttctcctct cgtttgagct tgaagaaatt atgaatctca gtgacagaat 2829061 cgccgttatt tttgaaggac gcattatcgc cagcgttaat ccgcaggaaa ccactgaaca 2829121 ggagcttggt ctcttgatgg caggaagcac gcaaaaggaa gcggggaaag caaatggtta 2829181 aacgactctc tcatttactc gtgccgctca tcgcaatcat acttggtctt gcggccggcg 2829241 cgttgattat gcttgtgagc ggctacagtg tggctagcgg atattcggct ttgtggaatg 2829301 ggatattcgg agaaatctat tatgtcggag aaacaatccg gcaaattacg ccttatattt 2829361 tatccggatt ggctgtcgcc tttgcattcc gaaccggact ctttaatatc ggcgtcgagg 2829421 gacagctgct cgtcggctgg acagcagcgg tttgggtcgg tacggcgttt gacggaccgg 2829481 catatattca cttgccgctc gcattgatta cagcggcagc tgcaggagga ttatgggggt 2829541 ttattcccgg cattttgaaa gcgcgatttt acgttcatga agtcattgtc accattatga 2829601 tgaattatat cgcgctgcac atgaccaatt acatcatttc aaacgtcttg acagatcatc 2829661 aggacaagac ggggaaaatt cacgaatccg cctccctccg ctctcctttt cttgaacaga 2829721 tcaccgatta ctcacggctg catttgggaa tcatcgttgc ccttctcgca gcagttatca 2829781 tgtggtttat catcaacaaa tctacaaaag gatttgagct ccgggcggtc gggtttaacc 2829841 agcacgcttc ccagtatgcc ggcatgagcg tgcggaagaa tatcatgacc tccatgctta 2829901 tctccggcgc ttttgcaggt cttgccggag ccatggaggg cctagggaca ttcgaatacg 2829961 cagcagtgaa aggcgcattt accggcgtag gctttgacgg tatcgctgtc gctcttctcg 2830021 ggggaaacac agccgtaggc gttgtactgg cagcatgcct gcttggcggg ctgaaaatcg 2830081 gcgcattaaa tatgccgatt gaatcaggcg ttccatcaga ggtcgttgat attgtgattg 2830141 ccattattat tctatttgtg gcttcaagct atgcgattcg tttcgtcatg ggcaaattga 2830201 agaaaaaggg ggcgaactaa gtggacattg tgcagatttt atctatcatt gtccctgcca 2830261 cactcgtcta tgcggccccg cttattttaa ctgctctcgg cggcgtgttt tccgagagat 2830321 caggtgtggt gaatatcggc ctagaaggcc tcatgattat cggggcgttc accagcgtgt 2830381 tatttaattt attttttggt caggaattag gtgccgccgc accttggctt tcgctccttg 2830441 ccgccatggc agcaggcgcc ctgttttcac tgattcacgc ggcagcggcg atttcgtttc 2830501 gcgccgacca gacagtcagc ggtgtcgcca ttaacatgct ggcgcttggg gcaactttat 2830561 ttatcgtcaa actgatctac ggcaaagcgc agacagacaa aattccagag cctttttata 2830621 agacgaaaat ccccggtttg ggcgatattc ccgtcttggg aaagatcttc ttttcggatg 2830681 tctattatac gtctattctt gcaatagcac ttgcctttat ttcctggttt atcttgttca 2830741 aaacgccgtt cggccttcgt atccgttctg tcggcgagca tccgatggcg gccgatacga 2830801 tgggaatcaa cgtatataaa atgcgctaca tcggcgtgat gatcagcgga ttgttcggcg 2830861 gtctcggcgg cggcgtatat gcctccacaa ttgcgcttga tttcacgcac tctaccatct 2830921 ccgggcaagg ttttatcgcc ctggcagcgc ttgtattcgg aaaatggcat ccgatcggag 2830981 cactgggggc cgccctgttt ttcggattcg cccaaagctt aagcatcatt ggatcgctgc 2831041 tccctctttt taaagacata ccaaatgtgt atatgctgat ggctccttat atcttaacga 2831101 ttctcgcttt aaccggcttt atcgggcggg cagatgcgcc aaaagccaat ggcgtgcctt 2831161 atattaaagg aaaaagataa acattctccc ctgggaagac gattctcagg gatttttttc 2831221 taatccaaaa gaccccctta atttaattgt ttattagttt tttaacttaa aaaaatatga 2831281 agtgttaacg ctttcttgta gactgtaaca aacaatacat gggggtgtat gacatgggag 2831341 caattccaaa aacggggaca atttcacctg agcaaaaaga ctcacaggag aaaaacctgt 2831401 ttcaaaaaat ttggtcttgg gaaatcggtg tgattccttt gccattatac acagtattag 2831461 ctgttattat tattcttgca gcatattaca atgagctgcc ggcaaatatg cttggcgggt 2831521 ttgccatcat tatgattctt ggtgtgtttc tcggagacat aggccaacgc ataccgatat 2831581 tgaaggatat tggcggccct gctattttat ctttgtttgt tccttcattt ttagtctttt 2831641 acaatgtact gaattcaaca tctttagacg ctgtaaccaa cttgatgaaa acgtctaact 2831701 tcctttattt ctatatcgct tgccttgttg tgggaagtat cctcggtatg aacagaattg 2831761 ttttaataca ggggtttatc agaatgttcg ttccactggt tgcaggaacg atcgcggccg 2831821 ttgcagccgg catccttgtc ggatttattt ttggctatag tgcctatgat tcctttttct 2831881 ttgttgttgt cccgattatt gccgggggaa taggtgaagg gattttgccg ctttcaatcg 2831941 cctattcaca aatactgggc tcatccgccg atgtatttgt gtctcagctg gtgccagccg 2832001 caattatagg aaacgttttt gctatcatat gtgcagcctt aatgaaaaag cttggcgaca 2832061 agcgtccaga tctaaatggg aacggacgtc tcgtaaaatc taaaaaagca aatgagattt 2832121 tcaatcaaaa agaagccgaa gcaaaaattg attttaaact aatgggagca ggagttctgc 2832181 tcgcgtgtac attctttatt tttggcgggt tattggagaa attcatcttc atcccgggcg 2832241 cgatcttaat gattatttca gctgcggctg tcaagtatgc aaatattctt ccgaaaaaaa 2832301 tggaagaagg cgcttaccag ctttataagt ttatttcttc aagctttaca tggccgctga 2832361 tggtcggtct cggcatcctc tttattccgt tggatgacgt agcgtctgtg atttctatac 2832421 cgtttgtcat catctgtatt tcagttgtta tcgcgatgat tggttctgga tatttcgtag 2832481 gcaagctgat gaacatgtat ccggttgaat ccgcaatcgt tacctgctgc cacagcggtc 2832541 tcggcggaac gggtgatgtt gccattttat cggcatcagg aagaatgggc cttatgccgt 2832601 ttgcccaaat ttcaacccgt ctcggcggtg caggcacagt tatttgcgcg acagtgctgc 2832661 ttcgtttttt cacttcataa acagaaagag ttccgtttta tgcggaactc tttttttatt 2832721 tattcacaat ccgaatatac tctcggggac caaacggcag atcctttgat tccgtctcac 2832781 tcattctggc tgacaggtgg tgctccagta aatacagctc ccactcatca caagccgcca 2832841 caccgctgcg cccgtcatat tgattcaaca tgaatgcccc tgcaaatact gagcagaata 2832901 aacctgagca catcacgact tttgttttca catgaccagc tcctttcctt cagcttgatc 2832961 aggattgatt ttaaatatac aaataacctc ttttttgtta gacttatttt gaggtcaaaa 2833021 gaactcataa aaatccatta cagcagttcg aagcgtggca gcttgcagaa aagtgcgata 2833081 taatttggac taggtcgttt gaccgtatat tttatacata gcgcattttt caattgagaa 2833141 cgagaaaagg aggtcttatc tttgcagctc ttacatcttg ctattttatc gcctttttta 2833201 tttgctttta tcattccctt cttggcaaaa tacgcaaaaa gagtgcatac gggctggttt 2833261 gtgttgatcc tgcccgtctt gctgtttata tactttctcc caatgatcag gatgacgcaa 2833321 tctggagaaa cacttcgatc ggtattagag tggattccgt cactcggcat taactttacc 2833381 gtttatatag acggcctcgg gttattattc gctttactga tcacaggcat tggctctttg 2833441 gtcactcttt acagcatttt ttatttatcg aaagaaaaag aacagcttgg gcccttttat 2833501 gtctacttat tgatgttcat gggcgccatg ctcggcgtcg ttctagtaga caatgtcatg 2833561 gttctctaca tgttctggga gcttacaagc ctttcatcct ttttgctgat cggctattgg 2833621 tataagcggg aaaagtcgcg ctatggcgca gccaaatcac ttttgattac ggtcagcggc 2833681 gggctgtgca tgctcggcgg atttattctc ctttatttga taacggattc cttcagtatt 2833741 cgagagatgg ttcaccaggt tcaattaatt gccggccacg aattgtttat cccggctatg 2833801 attctcattt tattaggggc ttttacgaaa tcggcgcaat ttccttttta catctggctc 2833861 cctgacgcga tggaagctcc gacgcctgtc agcgcttatc tccattcagc tactatggta 2833921 aaagccggca tttatgtgat tgcgagattc agtcctattt tcgccttttc agctcagtgg 2833981 ttttggatcg tgtccctcgt cggcctcttt acgatggttt ggggttcatt ccatgccgtg 2834041 aaacaaactg atttaaaatc gattttggcg ttttcaaccg tcagccagct cggcatgatc 2834101 atctccatgc tcggagtcag tgctgcggcc cttcattacg gacatacaga atattataca 2834161 gttgccgcta tggctgccat tttccatttg atcaaccacg caacctttaa aggaagcttg 2834221 tttatggcag tcgggattat cgatcacgaa acaggcacac gggatatccg gaagctaggc 2834281 ggcctgatgg cgattatgcc gattactttt accatttcct taatcgggac attttcaatg 2834341 gccggcctac cgccgtttaa cggatttttg agtaaagaaa tgtttttcac aagcatgctt 2834401 cgcgtgacac attttgacct gttcaacgtg cagacatggg gcgttctgtt ccctcttttc 2834461 gcctggatcg gaagtgtatt tacgtttatc tacagcatga aattgctgtt taaaacattc 2834521 agaggaaatt accagcctga acagcttgaa aaacaggctc acgaagcgcc tgtcggtatg 2834581 ctcgttccac cggtcattct tgtcgctttg gctgtcagtc tcttcttttt cccgaatata 2834641 ttgtcgtaca gcctgataga gcctgcgatg aactcaatct atccgacact gcttgacggc 2834701 catgagaaat tccacgttca catttcacag tggcatgggg ttacaacgga attgctcatg 2834761 actgcgggta ttgttgtgat cggaacaatt ggttatttgt cgctgaataa gtggaaagga 2834821 atctataaac tgtttccttc gaaactcaca ctcaaccggt tatacgataa gcttttgact 2834881 atgatggaga aaggctctta ccgggtcaca aaacaatata tgaccgggtt tttaagagat 2834941 tatttgctgt atatcttcgc tggtttcatc attctgatag gcggagcttt tgccattaaa 2835001 ggcggatttt catttaaaac ggaaggcatg gctaaaatcg gtgtatacga aatcattttg 2835061 acgcttgtca tgatcagcgc cacagtggcg actgtttttg ctaggtcaag actgacggcg 2835121 atcattgcac tcggtgttgt cggttatacg cttgcattgt tttttgtcat tttcagagcg 2835181 ccggacttgg cattgactca gctcgtcatt gaaacgattt ctgtggcact gtttctgctt 2835241 tgcttctacc atttgccgaa actgaggctg aaaacaaaaa cgagaacgtt ccggatgacg 2835301 aattttatca tttctttagg cgtcggtgtt atcgttacac tgctcggcat cgcatcctca 2835361 agccagcgga caaaagacag cattgcgtcc ttctttgtca aacacagcca cgatctcggc 2835421 ggaggggata atgtcgtcaa tgtcattctc gttgatttca ggggatttga tacaatgttt 2835481 gaaattacgg tattaacgat agccgctctc ggcatttaca gcatgattaa aacaaaagta 2835541 aaagaggagg ggaaaagcgg tgaatgaaca aaaaacaaat gacttgattc ttcaaaccgc 2835601 gacaaagctt gtatccttta tcattttgct tttctctttc tatttatttt tatcagggca 2835661 taacgcgccc ggaggaggct ttgtcggcgg actgatcacg tcctcttcca tcgttctctt 2835721 gctcttggca tatgatttaa aaaccgtgcg ttcccttttg cctgtcaatt tcatttatgt 2835781 cgcgggagcc ggccttctgc tcgctgtatt aacaggcgtt ggctcctttg tcttcggggc 2835841 tcctttttta acccacacat tcggatactt tcagctgccg atccttggga aaacggagct 2835901 cgccacagcg acgatatttg atttaggcgt ttatcttgtt gtcgtaggca taacgatgac 2835961 cattattcaa acgattggag aggaagaata atggaaatct taatggctgt attagccggt 2836021 attattttta tggctgctac gtatttgctg ctgtctaaaa gcctgcttcg cgtcattatc 2836081 ggaacagcac tgttaagcca tggcgttcat ttaatgcttt tgactatggg aggattaaag 2836141 aaaggcgccg ctccgatttt gagcgagcat gccaaatcat ttgtcgatcc gcttccgcaa 2836201 gccctgattt tgaccgcaat tgtcatttct tttggcgtta cgtcattcat cctcgtcatg 2836261 gcctttcgcg cttatcagga attgaaatcg gacgatatgg atcaaatgag gggaaatgat 2836321 caacatgaat aattttgtta ttttgccaat cctgatcccg cttttgtcgg ctattcttct 2836381 gattttcatg acgaagaatc ttatgctcat gagaatcttc agcacggcgg catcggccat 2836441 cgggattgtg attagcggca tacttgtaca gactgtcttc acaaaaggca tccagacact 2836501 cagcctaggc ggatggaaag cgccgtacgg cattgtgctt gccgcagacc aattcgccag 2836561 ccttctcgtt ctcacaacag cgatcatcgg tttattggtt gggctttatt ccttccgttc 2836621 tgtcggtgaa aaacgggagc gctcctttta ctactccggc gttcagttct tgcttgccgg 2836681 cgtcagcgga gcgtttttaa caggcgattt atttaatatg tacgtatttt ttgagcttct 2836741 gcttattgct tcctatatgc tgattgtatt aggcggcaca aaaattcagc tgcgggaatc 2836801 ccttaaatat attgtgttta atattgtatc gtctgccctg tttgtcatag gggtcggctt 2836861 tttatacgct gtaaccggta cgttaaacat ggcggatctt agcgtgaaaa tcagcgaatc 2836921 aggacaaacc gggctgatca ctgtgattgg tgtcctgctg cttttggtat ttggcatgaa 2836981 gggcggaatc ttccccctct acttttggct tccaggctct tattacgcgc caccggcggc 2837041 aatctccgcg ttgttcggcg ctttgctgac aaaagtcggg ttatatgcga ttacgagggt 2837101 tttcacattg atttttattc acgatacagc ctttacccat cagttgatga tttggctggc 2837161 ggcgctgact gtgatttttg gtgtgatcgg ttcactcgct tattcgaatg tcatgaaaat 2837221 tgtgatctat aacattatta ccgctgtcgg cgtgattttg ttcggtgtgg cagtacacac 2837281 ccccgcatcc attcagggcg cgatctacta tctgattcac gatatgctga ttaagggcgc 2837341 tttgttcatg ctggcaggta cgctgatcgc attgactgga accgcgagcc tgcataaaat 2837401 gggcgggctg atcaaacgct atcctgttct tggatggatg tttttcattt ccgctatttc 2837461 tcttgcaggc attccgccac tgagcggatt tgtcggcaaa tttaaaattg cagagggcgg 2837521 cttcgcagaa ggtgaattta cgatatccat gctgattctg ctttcgagtc tgcttgtact 2837581 gtactctgtg ctgaggatct ttatacatgc gttttggggc gaagaaaaag aaacgccaaa 2837641 accaaatcat cgaacagcta aaggacttct ttatccggca gctatttttc tcttgctgtc 2837701 ccttctcttc ggattgggta cagaatgggt gtcgccttac gttgatcaag cggccgagac 2837761 gctgctgaat ccggaaaaat atatcgaagc tgttctgaag gagtagatcg catggcattt 2837821 caaattttat taaatgtgtt tctcgctttt tgctggatgt tcttaagcaa cagtccaagc 2837881 gccgcaggat tcattacagg ctatattctg ggaatgctct ctctcttttt cttccggcgc 2837941 tttttcactc gccagtttta tctatggaaa ttgatttcta ttatcaagct ctgtttcatt 2838001 tttataaagg aactgtacct tgccaatgtc agtgtgatga aatcagtctt atctccaaaa 2838061 ctgaatatca gaccgggtat ttttgctttt aaaactgaac tgacgaagga ctgggaaatc 2838121 accatgcttt ctctgctcat tacattaacg ccgggaacct tggtgatgga tatttcagat 2838181 gacagaacaa tactttatat tcatgcaatg gatatcgagg atgcggaaaa agcgattttt 2838241 gacattcggg agtcatttga aaaagccata caggaggtga gccggtgatg tttacgctga 2838301 tcctgcaaat cgcgctcggc attatggcag tgtctacctt tttgtatgtc attcgtgtca 2838361 ttaaaggtcc gactgtgcct gaccgggtcg tggctctgga tgcaatcggc atcaatctga 2838421 tcgcaatcac ggcgcttgtc tccattttgc tgaaaacaag tgcgtttttg gatattattt 2838481 tgttgctggg gattttatcg tttatcggaa cgatcgcatt ttccaagttc ctggagaaag 2838541 gagagattat cgaaaatgat cgaaaccgct aaggtcgttg tggctgtatt cattttgctg 2838601 ggtgctctta tatgcctcat tgcttcattt ggcgtacttc gccttcccga tgtgtttaca 2838661 cgcgctcatg ctgcttctaa aggctcaaca ttaggtgtca atatgattct gctcggtgtc 2838721 ttcttctatt tgtggtttgt gacgggggag ctctccgcta aaatcctgct tgggattctc 2838781 tttatcttta ttacgtcgcc tatcggcggg cacttgatct gccgtgctgc gtataactcc 2838841 ggcgtcaagc ttgatgagag aagtgtgcaa gatgactata acggaatcag aaactttgtg 2838901 attaaacgaa aagaggattc ttatttataa aaataagcag ccggacaggc agagttccgg 2838961 ctgttttttt atttcttgat gacagccagc gtgcatctgg atatacagat cagcctctct 2839021 tgctcgtcat atatgtgaat atgatagaca atcgtcgttc tgcctatatg aacgggctcg 2839081 gctatcgcct ttaccgttcc ttcctttaca gattttaaat ggttggcgtt aatctccaaa 2839141 ccaacacaag cttgcgttgt atgatcaatc aggttctgtg cacctgcgct cgccgcggtt 2839201 tccgccaggg ccactgaagc gcctccatgc aaatatccga acggctgtac cgtccgatga 2839261 tccaccggca tgaccgcaac gcatcgttcc gctgtgtttt caacaatctc aataccaagc 2839321 gcttcaagca atgtgtgctt catatccatc tctacacccc ccaacattta aagtacaccg 2839381 tctgatttcg caatcaaaac cgcttccgtc cgtgaaccga cattcagctt attgaaaatc 2839441 gatgtcaagc tgtattcaat ggaccgcttg cttaaatgaa gggcatctgc gatttcttgg 2839501 tttgtaaatc ccttttcaac ttcttgaaga atcaggcatt ctctaggtgt gagcacatct 2839561 tgttcttttt gagaggaagg agccggcttt gttttttgct gagtcatcag ctgtttaaag 2839621 taagcaaaat cgactaaaat ttctccgttg agtacgtggt atatgtattg ggtgatcttt 2839681 tctttagatt ccgttttgct gatggcaccg tgcagacccg cacgaatcgc ttcctcgaaa 2839741 taatcctcga cctcataacc ggtatacacg ataattttac aatgaggatt ctcttgtaaa 2839801 atctgtttag aaagctccat cccattgacc tcgccgccta gattcagatc cattaaaatg 2839861 agatcatatg acgagaaatc atgctgcttg ataaactgtt cgctcggttc aggactgaga 2839921 caatcaacag acaaattcga atccgtttcc aaaattgtct tggtgccttc catgacagcc 2839981 ggatggtcat caatcactag tatctttttc atgttttcct cccttttact cactcttttc 2840041 cattttataa aaaagacttg gcctgtgcca agtcgtttcc gttataaatc cattacaatt 2840101 cgatttcaat atcagcctta aagccctttc cttcacttgt ttcaatccga aggcgcccat 2840161 ctaaagccct gactctctcc ttaatgccag aaagccccat gctcatggaa tgctcagtat 2840221 ttttttcttg atcaaaccca acgccatcgt cctcataatg aagaacgatt ttgttttgaa 2840281 tactgatgag cataatcagc acatccgtcg cctgagagtg cttgaccgca ttagacagaa 2840341 actcttgaat gatccggtac aaattcagct gcgaatccag atcaagggaa gccgtaaatc 2840401 tcccggtatt taaacggata tgaaacggaa cccgctcctg ctgctgcgcc accagcttcg 2840461 acagcgcctt caccaatcca agatcataca gaagctgcgg ccgcagctca tgacacgtct 2840521 ccctcgtcat cgaaatcaca tcagacatct gctcattcat ctgtacaagc ttgtcctgca 2840581 cctcttcacg gcacggatta tcatccttct tgaaatcacc caaaaacagc tcacactggc 2840641 gttttaagga aatcaaatcc tgaagaaccg aatcgtggag atcgcgggcg agtcctgaac 2840701 gctgtttttc ttcgattgca aacattagct ttttcagcca gatggggttg gttccctctt 2840761 gttttaagtc cttcaaatgt tccatgagct cctcaatatg caggacattt tccatggaca 2840821 cacttgtata aaaagacagt gttttcagcc acgatatttc atcacgtgtt agccggggag 2840881 tgttaatatt agataaacaa agcagaacat aagaactacc gcctcgttca ccaactttca 2840941 taagaaagcc ttgattgact tctataattt tcccaatttc tgaagttacg ttttcaaatt 2841001 cctcttgata aaaattccag tccggtccaa cttcatgctt atctaaaaat atcactttgt 2841061 gatcaggagt aacctcaaag gtataagctt tgcttacaag caaaacatcc agtatagtat 2841121 ttttcagttc tttaaaaact tgttgaagag aagttacacc cctcattagc tgagtatatt 2841181 taaaaatact gtcctgatag ttgaattttt cggagaaacg ttttaaccga aatttaaaat 2841241 ccatgacctc tttaaaataa aagacagcga acatgacaac gaaaaaaaat acagtttgac 2841301 gcacagggtt catctggatg tccattacat caaacagaac taatgcacca actattagaa 2841361 gagttggtat catggcaagt agagcatagt atctcattct tcctaagata aactctatat 2841421 caaacatctt attggctaca aattggtata ctaacccgaa cggaattagt actagtaatg 2841481 acgccgaagc taatgccggg aaaatataat tacctgtaaa tattattgga agaacaaaaa 2841541 atatcaaaaa aggcgcaaat gaaagagtgt ttgttaaaat tagtaattta agaataaacg 2841601 aatgctcagc atatttatat ttattaagat gtaagtatat cgctgaaaaa gaaaatagag 2841661 tcaaagttgc aaaagaaacc aaattaagag ttgctaaaaa atcaatatct acttgtaaat 2841721 agtcttgaaa aaactcaata ccaagattaa atattggtat gatataaaga aaagaaattc 2841781 tattcaaaaa agttttacct atttctccaa ggtatctttg tataaattga agataaagaa 2841841 taggagaaga tataaaagta aacaagttaa tataccgatt gattatatgt cctctaaatg 2841901 gtccgcctgc acttatatat gctatcgaaa tgtctaataa caatagaata agaatatagg 2841961 cagcaaatga tctccttttt ttatttactt taagtatata aaaaatacat attatgctta 2842021 aaaaataaaa aaacaaagga agtacgaaca gaaaaaaact ataaggtcta tttagagtaa 2842081 ctaaatcaaa atctttgaga tgaatctttt ttccacttct caaaatatcc agactgttaa 2842141 tatgactcaa atatccccat ttcaaatgtt tgtctgaagg tttttcttta ttaattttta 2842201 atatgatgtc tccctgtctc agaccaacaa attgtccata tgaagattcc gatatttctt 2842261 ctatcataaa ttgactttta tcatttttat gaatcttagt cccaataata attccattca 2842321 tactgatata agttgtatag cttatataaa ggatactcaa aacaattaca gctattgtga 2842381 atttttttat taagttcttc aatattaatc cacctattaa tcaccccatt gacgggttat 2842441 tggatcagcc agataataat cattataagc tttaattatt gtttcagttt cttgcacatc 2842501 aaaacctata aggcaggctt ctttattttt caattttttt aaagcctcag gataatttaa 2842561 aaagtagtta attaggtctt gcatcttgta tccccctttg tataacttaa taagcattcc 2842621 tttattagct ctttttttct ttatctaaat ttaattgttc tatagcagaa atacatttct 2842681 gtttatatat ttccaataat accgaaatgt attgagtaac tcccgcttta attaattttt 2842741 cttggaattt ctctttatca agtaacgatt tataatataa gtctttatgt gaaattaagt 2842801 ataataaatc ttccgaagca tcattaaaaa ggcgcttaag atataagtaa atcagtgtat 2842861 gtttgttttt ttcaatatca ctgcgatttc cggataaaag aacataataa tctccagaaa 2842921 tttgagctat aatcccttta tagtaggaat atctttcaac tgtttcatta tattctcctg 2842981 tagccaataa aacacctgct acatttgcta gtgcaatcag acttccacat tttaatctaa 2843041 ttacttctaa actttcatct tctgttttag atttattagt gatatcgtca tgttgacctt 2843101 gcatggcctc gtttacgtat tttaaaacat atttaaaaat tagaggattg ttatttaatg 2843161 aataaatact cgttaatcct actgtataca aggaaagtgc tgcatttaac gactccgagc 2843221 gattaatttt catccataat gcatggtgat tatcttcatc ttcaagatca tccataatat 2843281 ctgatgaaag aataagaatt tctattcccg cgccaagcct tgttgcaaca tctaaattct 2843341 cccctccaaa aacaacataa tgtaagattg tggattcagc aaaggagaat gtttctttag 2843401 aatcaataaa tgagtaaaga agttgtgaca aatcctcgtt aaatatgttt tgctccacaa 2843461 tctccttcat tttctccttg atccggacag aatctaaaca tatctgctca ataacgactt 2843521 cccccctccc attccatttt actaaatggg acatttaaag gacagcaggt ttttcgtttt 2843581 ttaacaatca tataatactt tatccattta ttgtatcggt agaacgaaaa aaaagacttg 2843641 tttccaagtc tttttcacga aattttcatt gcataattgt atttatcgag ttgatcaatg 2843701 cttttgttaa tgtttcgtaa tgaatctgtc gtttctttaa tatcaagttc gagtcggaat 2843761 aacaattgtt ttacttcttc aagtttcttt tccatcgttt ccacactcct ttttttgaaa 2843821 gatcaatgaa ttgtgtatgg tgaacgagtc ctaggtattt gatctgttac taatagtgtg 2843881 tctgctttcg gctcattttt caccgaaaag tatgcaaaaa agtcctgcgt gacaccgcaa 2843941 atctcaatag gtccttatac tcaaaggaat cacaacaaga acgggactat ctttctatgc 2844001 gaaagagcgt ttatatgtgc tgaaattgag aaagattctt aatctccttg attttaacgg 2844061 gtttcgcatt ttcactaagc aagactatag tccttcatac cgtattttca aaattgaata 2844121 tgcgattctt ggcgtttcct gaccgacaaa caccgaaaaa gaccgcaacg ctaaagttgt 2844181 ggccttttcg ctttgtcata ttcggcaatt agggatctat acatatagaa acatcctttt 2844241 ttgcgaggtg ctcccatgag atatcgttat ccctggtttt acgtgtatcc gtatgaggta 2844301 cgccgtccgc ccgctcctgc caacaatatt gataccttta tccgttcagc gaagcaggcc 2844361 gcagggatat ttgcggatgc ccagctcgtt ctcagccgca ttgcgggctc gcgggagctt 2844421 tcgcgccgca ttctgaccgc agccgaacag tctgataaac aaactataag gcgcctgatc 2844481 aaacaaatgg gcgtccggca tgaagtggat acggtcttta atcccgacgg catctatatc 2844541 agccttatcg gaacgcaaag ccgaatgatt cttgctttgc ggtggtcaga ggaccgcaat 2844601 cattttgcgt ccataagatt atgacaccat tccagagcct ctaaataaca ttcatacgct 2844661 tcttctttgt ccagttgatt gcctaattct gagcaagtgt cccagttgtt gctttcaatt 2844721 aatttcacaa gctcaagcat ttggtagtag tcgttttgat ggcctaataa tgcttgcccg 2844781 acttcatctt ttaaaggcaa ttcttgaaca atttcctcta tttctctatg caggagggtg 2844841 tctatgagag aaaacattcc gatcagcata taagaagcag gctgcggccg ggatgtcttt 2844901 ctcgccagca gttcgcaaag ctttgctctt atcagagaaa tcttaatgat ttcgtgcttg 2844961 ctggaatgcc ctttcctgct taaatcctta aaggaaagaa tatatatcca ccgtttgatt 2845021 tcattaaatc ccagcagcat aatggcctgt tgaatgcttt caattttctg gctcaaacgg 2845081 ctgtgggatg agtttaaaaa ttttaaaatt tgataggaca gtgataaatc ccgctctatg 2845141 tactctgtca cacgctttat gttaggctgc tctttactca gttcgttaag cagttcatag 2845201 taagaataga aatgagtcga taggtcatgc ccgctgatga tgcgcggctc gctgaaaaag 2845261 tagccttgga ataattgaaa gccgtcttgg accgcctgtt tatattcttt tcgggtctct 2845321 actttttccg ctaaaaaaat caggccgcgg cagccgtagg tttgcaaaat tgttctgcgt 2845381 tccattcgtg ttgttttgag aaaatcaatt ttcaatatat caatatagct catgagtttt 2845441 tccagtaagt cctcatcttg cggatttatt gcataaaaat catcaagcgc cagcatatac 2845501 cccatttttt tcaattcttt gcatctagaa atgagggccg gcgtgatcgg tatatcttca 2845561 aggatttcaa tgacaagctg tttcggattg aaggaggtgg gaagattcga aaacatcagg 2845621 ctttccgtaa aattaacaaa acagcgtttc ccttccgtca gcttctcaat tccgatgttt 2845681 aaaaagctgt tgatcaccaa atctgttgtt gcctgatcgc cgtctttagc gctatacacg 2845741 ttctcttcgc tttctctata cagcagttca taagcaacaa cctgttcttt tctattaaaa 2845801 ataggctgtc ttgcaacaaa caccctcatt gatttatccc ccttacaata cgcgcggctt 2845861 tcacccctaa gtatatcaaa taatttgacg aaaattgtct aaacatgaaa aataatatat 2845921 acataaagaa aactggccct tcgcgaatga aaggccagtt tttctttatt cttcctcaag 2845981 ctcttcttca attctgcttt tcacttcgtg gatccgctgc attttattgc tccagcagtc 2846041 ctcgcttaaa tcaaccgggt attcctccgg cttgctgatt ctcttatatt cctcccaaag 2846101 caggctgagg ttatcctgca catactgctg tatgtctgaa atctcagggt tttggtagca 2846161 aagaataccc ttctcaaaaa tcagttcatg aagatccttc gcataaaaat tcgtgacaaa 2846221 tttgctgatg aatgtatgaa ccgggtggaa cattctgagc cgcttctgat cattcacctg 2846281 ctcatcataa agcgcaatat agtcgccttc agaatgatgg ttggactgat taataatgcg 2846341 gtagactttc tttctgcccg gtgtcgtcac tttttcagga ttggacgaaa ttttgatcgt 2846401 gtcgaccatt ttcccgtctt cttcaatggc aacgagttta taaactgcgc cgagagccgg 2846461 ctggtcatag gcagtgatca gcttcgtacc gacaccccag acatcaatgc gcgctccctg 2846521 agcctttaaa ttcataatgg tgtgctcatc caaatcgctt gaagcaatca ccttcgcatc 2846581 tgtaaatcct gcttcatcaa gcattttccg ggcttttttt gacaggtacg ccaaatcgcc 2846641 gctgtccaga cggatgccaa tgaaattaat gcggtcgccg aattccttgg caaccctaat 2846701 cgcgttcggc atgcctgaac gaagcgtgtc atacgtgtca actaagaaga cgcaatcctt 2846761 atgtgtttcc gcgtattttt tgaaagctgt atattcatcg cggtaagcct gcacaagcgc 2846821 atgcgcatgt gtgccggaaa ccgggatatt aaagcgcttt ccggctctta cattgcttgt 2846881 cgcgctaaag ccgccgatta aggctgctct cgctccccac atggccgcat ccatttcgtg 2846941 cgcccgtctt gttccgaatt caagcgcaac ttcatcaccg atgacgcctt taatccgggc 2847001 agcctttgtt gcgattaatg tttgatagtt cacaatgttg agcaaagctg tttcaatcag 2847061 ctgcgcttct accaggggtg cctccaccct cataatcggc tcattgttaa aaacgagttc 2847121 tccttctttc atggagtaaa gtgaacctgt aaaagataag ccgcgcaaat attcaataaa 2847181 atcttcatga tacccgagtt catcctgtaa ataactcaaa tcgctatccg taaacttgaa 2847241 attttccaag tattcaatgg ctttttccaa gcccgcaaat acggcatagc cattttcaaa 2847301 cggaagcctt ctgaaaaaca gctcaaaaat cgctttcttt tcatgaatgc cgtctctcca 2847361 gtacgtttcc gccatattga tctgataaag gtctgtatgt aatgacaggc tgtcatcttt 2847421 aaatccgtac tctaacactg tttttcccct tccttactct gccacttgcg ctccgatgct 2847481 gtttgcaaaa tgggaaagag cccatgcgtg cccctcctga ttaaagctgg caacagcttg 2847541 tttatgcaca acaatccgaa aacctttgtt gtatgcgtca acagctgtat gcaacacaca 2847601 aatatctgtg cagacaccgg caagatgcag ttcgccaatc tgccgctctc tgagtttgag 2847661 ctctaaatca gttcccgcaa aagcagaata tctcgttttt tccatgtagt aaacattagg 2847721 ttcatgttca tgtttctgat atagaggcaa aagctttccg tacagatctt ttccttccgt 2847781 gccttttata ttatgcggag gaaaaagacg ggtttcaggg tgatattgat ccccttcatc 2847841 atgagaatct actgctaata cgacgtaatc accgtttgtg atgaattctt tagttaaatt 2847901 gacgatcgcc tcttcaatca ttctgccggg ctccccgcag gtcaattttc cgtcactcgc 2847961 cacaaaatca ttcgtataat caatacaaat aagtgctttt ttcatagccg gcctccccgc 2848021 catcagtatg agaacattat atcttatctc cagttgtaag tgaattgcca tgaacaaaaa 2848081 gacaaacggt ccgtttgtct cttacgattt cagtactgac cgattataaa tgtcgtcctg 2848141 aatatatatc aattcacgat tcacagcgat atcagccgca atgacgatgc ctaagggcgt 2848201 atgaaactgg agatcagata caatcttgaa aggcactccg taccggctcg ccatttggat 2848261 ataagaagag taagactgat actgaagctc tccattaatc aaaagggtga cgttatggct 2848321 gtttttcagc tcgtgctctg cctctttata cggtttgctt ctaagcacct gtcctttcgt 2848381 cagtgccaaa acgactcttt ctcttaaaga gcctaaaaac aaatggcgct cgtcaggctt 2848441 tgtctccaaa ggcccataca ttccttgctg caaatagaga tccattttat cttcactcaa 2848501 aagcctgtcc tcccgtcttg tttgtcttca ttatcacctg atcaggcagg agctaaactt 2848561 tcaagcgccg tttacatttc tgttacccaa tgaatgattt ttttggccag ctcaccagca 2848621 ggggtttcct ctgtatgccg gcgcaacgac gcttccagcc gttcaggcag agttgcttta 2848681 tcttcttcat aggaaatgat cgtgctccac tccagctgcg gtaccgctac aagcgtgcgc 2848741 agttcttttc tgttttcatg cagatacacg tccgtgatca ttccggtttg cgtattgata 2848801 tttgcttttc tgattttcat aacatgacct ctctattcaa agactaccca tattatacaa 2848861 taaaaaagca acagcctctt gtgaaaaggc tgttacccgt taaacgaaac tgtttcatca 2848921 gtgatatcgg catctttgaa gagagtttta ctcgtttggt tgttaatctt cacaaaatca 2848981 ccaagctgaa atgtgcctga ccccgcccct gaatgagcga cgcttttggg cgaaatcgca 2849041 aatacgtctc caaagcttgc cgcggcatta tccgtaactg acatgatata aatcggcccc 2849101 acaattgcag gcatttcccc acctccgcat tgatttacag catcatatgc aaggagccga 2849161 taatggtgcc cgcctattca gctggctttg cgttttcctc gagtcgtgac cgctggcgca 2849221 gcttgatcaa gcggacaata ttcaggaaga acgccttcac taccgcataa accggcaccg 2849281 ctaaaatcat gccgagaatt ccgccgaagc ttcccgctcc gattaatagc aaaataatcg 2849341 taagcggatg ggtattcagc cgctttccga tcacaagagg agacagcagg tttccgtcca 2849401 gctgctgaac gatgacgacc acaataatcg caaacagcgc tttggccggc gagtccataa 2849461 aaccgacaat gacagccggc gcggcaccga gaaaaggccc gacataggga atgatattgg 2849521 taatcgccat gacaatccca agaatcaggg catacggcag tccggcaatt aaatagccga 2849581 taaaacacgc tgttccgaca aaaagacaga ttaacagctg cccctggaaa tatgccgcaa 2849641 gcgtatcgga taaatcttta aaaatcttta agccttctgt ccgataagaa gccggtagaa 2849701 tttttactgc caaatgcgga aagcggtgtc cgtctttcag catgtaaaaa aggataaatg 2849761 gaacagtaat aataacaagc gtgatgtttg tcacgacacc aaacaccgca gataaactgg 2849821 acgtgatatt ttgcggcagg ttttggagaa aacttgtcaa tgactgttca atttttgata 2849881 tcgatacata atcctggttc atcatccagg taaaccattg agaatgggac aaatcctttg 2849941 tcagcgcctg aatctgtttt atataatcag gaaggttgtt aaacagccct gtcacctgtg 2850001 cggtgatgat aggtccgact gacgctgaaa taaaggcaag caaaccgata aacagtaaat 2850061 agatcaatag aatggataat gtccgcggaa tttttttctc aagcaggcgg acgaccggat 2850121 taaatatgaa atacaaaatt cccgcaatta gcatcgggaa aaacaatgtc gagataaaaa 2850181 caataaacgg ctgaaataca aatgaaactt ttgttgctac aaaaataatc agcaaaacaa 2850241 ataaaatctg caatgtccaa aaatggactt ttgatttcaa caagctttgt tcctcctagt 2850301 ttttctttgt ctgtcagata aaagaactta taccccatca ttgtaacaaa aatgaactca 2850361 tatcagaact cttaatataa tgaaaggagt gttggtgatg aaggccgtga catacgatac 2850421 agattcagaa ctggcttata tctatgttct tcctccgaaa aagaacagga atgtacggac 2850481 tgaggagctc agagtcaatg attgtctcct gctggatatc agccaagatg gcaaaatcgc 2850541 cggattcgaa tgttttggtg aggcagcaca cctctgtgcc ccatttgccg ggaaatcccg 2850601 gctgtatgta aaagattcag acggttatca ttttcgggtc tgccagcatg cttcagtccg 2850661 ttcctgctat acggtgtacc gtgtcacttt ctgtttttca gatggtgact atcaggaatt 2850721 tgccggcttt gaccttgatg gaacaatgta tcatagtgcg tttttacagc gcttaactga 2850781 aaaataggac gtcctgttgt acgcctattt ttcatgcgca agcactgtta gacccgctca 2850841 ctgtaatctg gggtgacgga aatcatgtgc tggattctga tcaaacaaac agaatttcgg 2850901 gctccttcaa ttgtgatatg gtcaggtttt acatcgatca gtctgcctct gaccgtatct 2850961 cgtactgtct gtataacgaa ccttgagccg atgagctttt taatggtctg atagacataa 2851021 ggatcgacta aagagaccag ttgcggacta ccttggttga ccatactttt atcccctttg 2851081 tgtgttttat ctcagcttat gccgcgctta tggataatga cacaggctta cctgataaaa 2851141 caaaggggtg cggagatttt aggagaatac gtttggaggc gggtgtaaag gaagtatcga 2851201 tgaagcggag acagcgaaga aagctggcgc tgttccgtac ttatacaggc tttatcacgg 2851261 atgcctgggc ttggtcgatt aattggtcca gcttttctat tttttttcgt gcggttgaag 2851321 gatcaatttg gcggtaatga tggtggccgc ccggctcttc atccagttcg tccgcttttt 2851381 tgacaatctg ctgcagtgtg tttttatcta attcgccttc aggcaaatag gaatctgtat 2851441 gaagcaaaat ggctagtgca atctcttttg ctgctttcgg ttcctcgcca agccgaatca 2851501 gaagtttatg cgcccgttcc gcccctttaa tggcatgaat gtcatttctt ttgtatttct 2851561 cataatccca ctttccgtct gtataccatt cataatggcc aatgtcatga agcagtgccg 2851621 cttttgctgc taaatcagga ttaatgtcag ccttcacaga cagcctgtat gcatgataag 2851681 cgcaggcaat cgcatgtgcc acgccggaac gctgaagata tttttgtgca attggatggg 2851741 tgaaaacatc cattaatgta acctttctca tggaaacccc tcctttagat atttttagaa 2851801 tcctaacata atttgcagag aaactcaatt cttatgtcac atcattttga tcttcttatc 2851861 atcattgtta taccctaaaa gcaacgtttc agtcagtata tgcggctgtt caataaaatg 2851921 cgctggctgc agccttttgt ataaaaaaaa gagcagaaaa tatctgctct acaaaaactc 2851981 tttaatatca taaatgcggc cgttttccgt ccctttttct agtaaagaaa gcagcgtgcc 2852041 ggcaataaag tccggactgc gaaggcttcc tgtttcattt aatttccgga atcgttcaat 2852101 gtggtggaaa tcctttttcg atgaagaacg gatgacggcc tgcatctcag tgtccatcac 2852161 tccaggtgag aacgaaatca tgttcaccgg cagctcttca tcctcctgtt caaatccgaa 2852221 tgtcctcgta aacatgtcga gcccggcttt tgaactgcaa tacgcgctcc atcccttata 2852281 tggatttttg gcggctcctg aagtaatgtt gacaaccgtc tttttgccgc tgtatgaagc 2852341 aaaccgtttt gtaaacagct gactcaaaag cacgggcgca gtcaggttca gctgataatg 2852401 gcgctgaagc tcgtcaagag acgcttcgcc ggcacgtttg atcggcgtta ccattccggc 2852461 gttattaata agggtaatac cagaataacg atctgaatcg atggatgaga gcaatgtttc 2852521 aaattgctgt tcagcttctt cgagattgat gaggtctatt tgatgctgcg ttagtttttt 2852581 gtgagagaca tctgttttcg ttctggataa ggcatggact tcatgcccct tttctaaagc 2852641 ctgtaatgca atggcttgac ccagcccttt tgacgctccg gtgatgatat aaagttccat 2852701 tggaaacctc cttttccgtt attattgtac ggcacctctt ttacacaaca caagcacgcg 2852761 gcctacgcct tcttgttttc ctgcgctgtg acttttggga tgaggaacac gatgcctgca 2852821 attccgagca ggatcagtac gacatagatc atcggcagca gcaatgatga tgtttcttgt 2852881 tcatcttctg tttccgttga tgatgtcttt gtcattggtt tttcagcaaa agtaattcca 2852941 agctgtttcg actgggccgc aatcgtgttg gaatcctcgg catttgttga tgtaaacaaa 2853001 tcttttatca gctcggcgtc cttgtccttc ggtttatcaa aagtgatatc cttttgttcc 2853061 tcaggcagtt ctgttttttc ttcatagtag gtatcttcat gcaaataatt cgtatcgatt 2853121 tcgatgtctt ttttctcata ctggtttggc gcgacatctg tattttcttc agtttgggca 2853181 gccgctgcag agggtatgaa aagggaaaag gagagcatac aaatcatgat ccccttttcc 2853241 atgctgcgat cacgcttcat acgtttcatc gctttctgct gtgtgttcag ccatcaaccg 2853301 gataatcagc ggcagagcca cggcaatcac cgtaatgatc agcagaactg ttattcccat 2853361 tgtaaacaag tgcccagtac cgtactggat gtcgatatat actttcgaaa ccggatcttc 2853421 aaatgtaaag ttcggcatga tcaaatcaat aagcggtgcg acatagaata ggatcattgc 2853481 tgctgaagca acccagccag ggattgatcc gaatctgaat gccgtccgga tgaaggcaga 2853541 gcttgcgacc agcaatagaa tcgtaaacac cgaccactta atcgtctgat cgtccggcag 2853601 tgaataaata ttcaagccga acaagctgat cataagtccg acaaggatat tcagaattcc 2853661 gaataacgct cctttgacga gaagcggtgc gttttggtaa tacgagctga aatagccgat 2853721 taacagactg ctgatcaaca caatgacaag gatgacaacc ggaggtaccg tctgaatttt 2853781 ttcttccgga acctctccgc tgattttaag cggattcgct aagtaatcat atacatagcc 2853841 attgttttgc ccgtctacta atgtatttcc gagtatgccg tatacgtcat ttcgcacgag 2853901 tttcgtggag gcgacatttt tcccccagtt gttgtttaag gtgtcggctt tcgcttgaac 2853961 atcattaacg ctttgctgca tgttggttgt gtaatcaatg atgccggact ggcgatcaga 2854021 caatgaaccc atcatgtctg acatttgcag cacttcctgg ccgaccgtat cttggacact 2854081 cagtgccatg gtaccagaca gcccatcgtt gctgaacgtc gcagattcct gtgttgcgcc 2854141 cgttacaagc tgttctgacg cttttgcggc actttcagag attttcgtca gttcgtcgag 2854201 aacacctgct tgagagtcac ggatatagcc gctgtagtcg tccgcaaatt tggtcatgcc 2854261 gtcgatgaag ctgttaatat cctcatctgt ttgcatcgtg ttgtttttga gagcttccca 2854321 gctggctgat tcttcaggtg tgagagccag gactgattgg acgttgccat cttgctcttg 2854381 gatgacttca cctttaataa tagtcaaaga gcctagatcc agattatcat ttagcgtaga 2854441 cttatataaa tttaaagagt tgtaatactt catcaagtta gaaatattat cagtttcaat 2854501 tctacttgaa aaaattgaac ttagtttttc tttctgatct atatagcctc tactctgcaa 2854561 agtttgtatt atttcgtctt ccaaattgta tattaaccta taagcatcat tgacattatt 2854621 atcaaaatca accaactttt ttgttaagtc accaatttga tcatttaatt ttgaaactgt 2854681 tttatttaac tctttaattt cttgatttaa ctcatcaata tgtttctcta gtttgttgtt 2854741 atgttcctct tgtttttctt gaagtgcatt ttctatttcc tctaatttta tcgctgcttc 2854801 gttcagacgt ttttttgcac ctgaaatatc agtttcaccg tcagctccgt caccctgtag 2854861 cccatcactt tgatttgagc catcgttttc atctgcgagt tcaatcaaag agaaatctgt 2854921 tttagaggtt cctgtattct ccgtgtttgt atcttgttca ggaacgtttt ttgaagattc 2854981 ttgatgtttt tgtcccgttt caatgttagt ttgaacatca ttttgtgatc cattatcttg 2855041 agtaccctct tctgatgagc cagtatcttc atttgttggc tgatcatcgg atgttggaat 2855101 atcattcgac ggttcttcag tattaggaga atcatcggtt gatggttctt cagcatcggg 2855161 tgttgttggt ttttcttgtt caggttcttt taacccttca gagatatctt taatttcagt 2855221 tgcaacattt ttgagctcat cccgctgctt ctctaaatcc aattttatat cttcaatatc 2855281 ttccttatct gtgtcatctt tattatcaga tgtgtcttct ccatcttcct tttcgtcgct 2855341 ttccttaggt ttaagtaaac taaggcggtt cttcccgata ttctcttgca attgatttaa 2855401 attttgatat ttaatagctt catattgact tttatatcga gatagaaatg cattaaacat 2855461 gtcattctca atttttttca tacccatttc ttgcaatggc acttgatttt gccttaactt 2855521 ttcagcattg ttcaacgcaa ggtttgtcag tcctatttgt gtcttcgctt ggccgatccc 2855581 ggttgccaat ccgctcatgc gttcgctgaa ctgattcgcc ttttgctgtg cctggatggc 2855641 atccagacct gtccggattt gctgctgtgt tgaatcctgg gctgccaaaa gcagcttttt 2855701 ctgattctct tgatattctt tgtacctttc aactgtatca atgaattctt tcagcgtgtt 2855761 tttggcttcc tccgccgtag aagctttttc ttttgtcgtg ccttgcgctt cattcattga 2855821 tttcttcagc tcatcgatta agtctttttg ctgtttgatt tcacctgcta aatcattaga 2855881 gcttggtttg taaaagttgt acatgacatt ctggaattca gattctttat tgacgatctt 2855941 gtcaaattct cctctgatgt tgtccacttt ttgcgaaaca aaattccagt ataaggccga 2856001 catttttttg ttcattgtct tttgggcatc ctcaagctca cgctgaactt tttctttgtt 2856061 aaccgcattc aggttatctt gaatgctgaa ttcgagcgtt gccttttgag gatggtcttt 2856121 gtcatagctc aaaatgtttt ttgagaagtc tgagggaatg tagacaatcg catcgtattt 2856181 ctttgaagcg agaccggtct cggccgcgct tcggtttacg accgtccacg aataatcagg 2856241 acgttcaccc agaacggccg ctacttcctt gccgaactgg gcggatttgt cctcttcatc 2856301 agactttacc tcatcactca atacgcctgt gtcttcattc accaccgcga tttgccgggt 2856361 agaattgact gcttttttcg ttgggtcgtc tccgataaat cggaaaaaca acaccggcag 2856421 cagcaaaatg atgatgacgg cggatattaa cttgatcaag ctttttcgtt gttctgtcat 2856481 ctagcactct ccctttcagc agaacataaa ggaatttgaa ctttttgctc cttcccgttt 2856541 tccacaacat atccgaagcc cggctgaatc tcaggctcct gtctttggta cgggagagga 2856601 atgacatttt gctcagactt tttcatcagc agaatcgcgt ggcggatttg cttcatctca 2856661 gtcgtcaagg agtcatagcc ttttgagaat tcgctgtggt ttccgcccgg gataaagctg 2856721 aacccaagat gagcgtatga tttcatgaag ttagcgagac gatcttgtat tctcgtatca 2856781 atcgtctgct ggaatctcgt tatcccgtca atcatcagca cgacttgtga gaatcgcaga 2856841 ttttgtgcgt ctccttggcg gacggcttct acatacatgg cttctcttgt tttgaaaatg 2856901 tcttctgctg tttcaatcca ctgctcaata tcttctttcg tttccaaata tgaaacatct 2856961 gattccttcg cataatgaga taagccgcgg tcaatcgagt caaacaggcc gatcatttcg 2857021 gtttcatcat caatcagatg ttcaagcatg acttttagga cgtttgtttt cccgcgctga 2857081 gtttggccta aaatcaggca gtgcttatgc ttgcccaaat caaaatagac tgggctgact 2857141 gtttcttcat gaagcccgat cggtacagat aaaggcttgc gttccagctt gaagcggata 2857201 gacaattctc tcgtcgacaa gctctcaggc agcatcggaa tcggtgccgg ctgctccatt 2857261 gaagcaaatc gcccttgaag tttctgtacg tctgatttca gctcgttgaa catgccgata 2857321 tcatcatcgg cgtcaacagg caggaacatt tgcgcgaaat aaagctcttc cttttgaatg 2857381 atgacgcgtc ccggaatcgg ctcaagattg aatttcggac ggccgtaaat ggaatatcct 2857441 tctgattgat ccatgagata atggacaatc tttgttttca agttatttaa caatgactgg 2857501 cggacagcat tcacccgcgt tgctgtcagc ataaagtaga tacccaagct ttgtccgtct 2857561 ctggaaagct ggacaaattc cgattcaagc tcatgcatct catccttgac aatgtcaaag 2857621 ttgtcaatgg tgataaaaat gaatggaagc tcttcttcgc tcagcgcatt gtacattttg 2857681 atgtggctga tttctttttc ccggaacaaa cgtttacggc ggtcaatttc ttctttgatg 2857741 cgaatcatga acttttcaat tttccttgac tggtccatca ggaagtaatc cgcggtatgc 2857801 gggagcttcg ctaatggcag cagcgttccg tttccgaaat caaagatata gacatgaagc 2857861 tcttcaggtg tgtatacgtc cgcaaaactc atcaggaacg ttgcggctgc aatcgatttt 2857921 ccgtagcccg aagagccgaa gatgccgata tttccatctt ccatcatctt ataagcaatt 2857981 ggcgcctgtc tttgcagatc aggttcatcg acatacgcaa agtggaaatg gtctttttcg 2858041 tttgaaggga aaagagtgcg cggaatacgt tccgcaagcg gcggcagcca agggcttggc 2858101 agcttctcga ttcccatttc atcttggatg cgttcaattt cgtcaactac agcttcgatt 2858161 tcggtttgaa cgtctttttt cgcgttatct tcggtatcaa cctcagaaag cgggatcaga 2858221 cccgtatctg tgacgatcgc gatttcatcc tcggtaccgt agacttcctc taagtaaggc 2858281 gccccgctcc atgcagattg gaacagctca tacacttcat tgtttccgac ctgcaaatag 2858341 ccgcggcctg ttacggtaat gtttgcggca tcgctgtttt tcaaaatttc tttactgtcg 2858401 gtggcatcct ggaccttgag cgctacttta aagcgcgagt tactccagat ctggtcgtcg 2858461 atgatgccgc ctggcttctg tgtcgccaaa atcaaatgaa cgccgaggct tcgtccgata 2858521 cgcgcggcac tgacaagctc cctgataaaa tcaggctcct cgcttttcag ctcggcaaac 2858581 tcatcagaaa ttaagaacaa gtgaggcatc gccacttctg ctttcccttg cttgtatagc 2858641 tttgtatagt cattgatgtg attgacttga tactggtcaa acaggcgctg cctttttttt 2858701 agctcgcttt taatggaagc aagcgcacgc atactgaagt ttttgcttcc ttcaatattt 2858761 gtgatcgtgc cgaggaggtg gggaatgtta cggaacggct gcgccattcc tccgccttta 2858821 tagtcaatta gtaagaaagc cgcttcatgc ggatgaaaat gcactgcaag tgacaagatg 2858881 taggtctgga gaaattcact tttccctgat cccgttgtcc ccgcaagcaa gccgtgcgga 2858941 ccgtgtgctt tttcgtgaag gttcagatac acaatgtcat ctttcccttt atagccgatc 2859001 ggcactgaca gcgacttcga cgattcactt gtcagccatc tttgctgaat gccgatttct 2859061 tttacttcct tcgcatgaaa aagctccagg aacgataccg tttccggaat ggaattcgta 2859121 atgccgacct ggtggttcag cgtccgcagt gtgcgtgaaa accgttcgtt atcctcacgc 2859181 tgatgatgat cgagacggaa cggaattctt accgcttttt tcttttgtat taaaatgtcg 2859241 ccttcatgct cattaatgta gcggacaaga gttgtaatgt tttccgacaa gctttccttt 2859301 gtttctgcag cgacaattgt cgagatgccc agatgctcat gctgcccttc taaatattcg 2859361 agaatgacat gctcagagat cagctgctga ttcgtgatga caaatacaaa atgcggtttg 2859421 aactgcagtt tttctttgtc atcttcgaga tcacgctctc tgatcaattc gtaaagtgaa 2859481 gacaggagct gatctcgggt ttgctcatta taaataaatc cttttgcata aatatggggc 2859541 atttgaaatt gcggaagcca cttcatccac tcccagtctt tatactcttc ttcatgaaaa 2859601 ataaatacga aacgcaaatc gtgatagctg ttaaagaacg acagctgtcc gattagctgg 2859661 tgaatctcat ttttcacaat ttgtgattta ccgacaagcc ccatcggacc ttctgccaaa 2859721 tcgaccgtca ccggcgcatt acggatatct ttatagacgc gttgcatgtg ctgcgatttc 2859781 tccatgaggt catcgatatc acgattcgcc aagtctccgc cactcatatt gatttcatag 2859841 cttgacggaa ctgttcccgt cccaagccgc agctggagat aatccttgct ttcaagtgat 2859901 ttttcccaga tccggtcact gatttcactt gttaagtatt tcatttgttc aaatgaagga 2859961 aagtgaaatt caagaacctg cttttgcttt tcagcaagtg cctgaagctc tttccgctta 2860021 ttgtctaagt aaagcttata tacacgctcc cgtttttcct cgcgtttttt ccgctggttt 2860081 ttatcacgga aatattgcac tgtcgaggta atgagagtca tcataaacat cgccaaagaa 2860141 acgagtataa atatgccgcg cggctggatg atggcaacta cgcccatcac gatcagcatc 2860201 acaagcggag gcaggatgac gagccacagc cctctgttgg tttgatcgct ctcctgagag 2860261 ggaaaactga aagaaacgcg gtcatccggc agatcgtata ccatccgcgg cgttcttctg 2860321 tactgcggat attttttctg catctctgta ctcggtttga ccgtttctgt taacgctgtt 2860381 tcaaactggg cataatgaac aatttctaaa aggtcttgtt ccgtcaccct catttgcgtg 2860441 aagttccaga atatttcatc ccccggcttg agcggcgtat tggcgttgat tttctctccg 2860501 ttcaagaaga tcgttccgct ttcagggcgg accgaccagc tgccgcctgc acggagcaaa 2860561 gaaaacgtgc tttgttctgc aaatgcaaaa tcttgcggat tcagataaat atctgcattc 2860621 gttttttctg aggaacatac aatttcatcc cgatttcccg taaaataaac ggatttctca 2860681 ggttcactgc ccgtcaatat caagcgtata tcctgctgat ccgtttggag agtaaatgat 2860741 atatccgtct caatcgtgcc gagacaatca tttcccagga aaacttcgta ttggccgccg 2860801 gattcctttc ttttaagaga aatcactccg ctattaaatg gaatggtgct gatcgtaaca 2860861 gaatccttca catcaggccc tatggtcacc ggatgagacg acgggaggtt agacagattt 2860921 aatttttgaa cgttattttg gtaaaaaacc cataatagac tcaaatggcg aaccccctta 2860981 cggccgaatg gcagcatgcg atgacctgcg cttcatgtct cacgttattt gtcatctttt 2861041 ttctcatctt tcttttctgt ttcttttttc tcgtcttctt tttccttctg ttcttctttt 2861101 ttcgcttttt cctcggctgc ggctttttct tctgccgctt tctcttctgc ttgtttttct 2861161 tcgtctgttt gtgtctgttc ttcgcttgta tcgactaacg atgtttcaga attagactgt 2861221 ttattttctt gacgttcttt ttgggctttt tcaagctcac tatttactga atcaagttct 2861281 ttttgtatgt cttcatcatt tgtatcctca gataaaagct gctgtttata tttagctagg 2861341 gcaaagtaaa tataatcatt gtattccagc ttacggccga tactgatcgc ttctttgtat 2861401 tctcctcgac cataatcaat ccaatataag aaatgctgag ggtctgattg aagggtgact 2861461 aaattatttt ctatattttt ggtttttgca ctccccaggt tttcgacctc aacataggac 2861521 gtcgccagct gatactgcac cgattcaggc aggctttccg catcgtactt ggacagtgtg 2861581 ctgatgactt cactgtactg cttgtttaag aacgcacggt tgctgtccac tatcgcctgg 2861641 tgctttggct gcgcgaaaaa taaggcgtac atcgaataaa taagtgccgg tacaagcaaa 2861701 acaatgagcc ccaggccgat atatcgctgg atgttccact tctttctcgg gatatgtatg 2861761 tatgtttttg ctttggcttc gagctcatca atatgggttt gaatcagctc gagcaaatca 2861821 tcataggatt cagcatctaa tatcgccttt gcctctgcgg agaacgtcag cgtttcattg 2861881 aatttcaggt agtcttcaaa cgcaaaagcg ccgtcaactg ccaaagccgc tgccgctttc 2861941 agctcctgcc atactctttc ctcatcacgc tcgtaaggag gaatgctttc ttttactcca 2862001 taatggagaa aataaggcgt aagcccttta tcgaatacaa tgttttcagg agcgacaatc 2862061 aaattcagcc tcgacagatt gtgctgctgt acggcttgaa caagctgata ggcaaactgc 2862121 catttacttt ttttatcctt agctttcatg aagcggaatg ctttatagga ggagggaggt 2862181 tggattgtga tgattacttc atcatccgtc acatcgattt ctttatgaaa aaatggattt 2862241 atatctttga tcacgttagc ttcaagaccg tcgagaagct ttattttttc ccgttgaaag 2862301 gtaaatgtat agccggcatc tgttttctcg gcaacagctt ctaattggtt ttctaaatat 2862361 gatttttgtt cacctgacat tcaaccagat cctttcataa tatttcaagc cggtctccgt 2862421 ttgtaatgcc gcaatcagac agcttgcatt ctccggaaaa caccttatcc ttgttcacca 2862481 ctctgatcca gtgcccttcg cgcggaggca tagatacgct ttgggcctgc caagcaatat 2862541 caattacttt tttcaccggg tggtaatctg acaatctgag atcaaagaca ctgccgttat 2862601 aatgtttcaa atctattgta atatcaatat acatttagga tcacccttac atagaaagag 2862661 cgccgtcttc ttttgaatca ggcgctcctt ccctttcata ctgttatccg cggatttgat 2862721 ttgcgatgtc ttggtcagta gactcaagtg tatttgctgt ttgatcaagc tgctgattca 2862781 catcttgaag caaatctgac attttgataa atgaaggttt gagctgctcg tattgatctg 2862841 cgaacgcttc gcttgaagca ccttcccaca tgcttttcaa atcagagatc attcggttta 2862901 aacgatcaac ctgatttaat acttcttggc tttcaacgcc gtattgcttc gccatcgctc 2862961 ttagctcttc gggtgtgaca cgaattaatc ctgccatatt cctcattacc tcctgtgcca 2863021 tcagcctaaa tatgggctaa ttcacttatt tttagaacgt cattattata aaaacagttt 2863081 ttcggcatag tcaaacaaat atgttttaat tttacaaaat gagtccaatg gtttaccccg 2863141 aatcactcaa aaatgacata tactgtaaag taaataggtt tattttctta atcttctctt 2863201 cattctccga ataatccaaa agacccaaat aactctccaa ctcccaaaaa aaacctttca 2863261 gaaaatttga tgctacagca ccatttctga aaggttcagt tttttctttc cttaattagt 2863321 cttgcctccg atgactttct tagaagatta ataggataag ctgtcgtatt atatgagaca 2863381 tacactgtcc tgcaaaaagg cgattacacc gccaaatgta tatagaacgt ttctctcatg 2863441 aaattgtttt tttgcttctg ttctttgttg ttgattttca caaacaacaa caatcataat 2863501 aaaaggaagg ggatgagatg tcaaagagaa atcaagcacg aaaagtaggg agatttatga 2863561 ccatgccgaa tgatccgttt aaatatagtt ttgacagact tgaagatgtg gctgatcata 2863621 tcagcgacgt tctgcggtgc ccgatcacca tagaggatgt taaccacaag ctgcttgcct 2863681 acagtacaca cagcgactgc acagaccctg cccggacgtc taccattatt ggcagaaggg 2863741 taccggagaa ggtgattaac aagctgtgga aagacgggac aattcctgct ctcttaaaaa 2863801 cggaccagcc gatcagagtc aagcaaatcg atgaagtcgg gctgagcaat cgcgtcgcta 2863861 tttcgatttg gaaaaacaag caagtacttg gcttcatatg ggcgcttgag atccaaaaaa 2863921 cattgtccga tgaagatctg ctgacattgc aaatggcagc aaaagcagtg aaaaacaagc 2863981 ttctcaaact tcaaatcaga aaaacgaaaa atgaagaacg cagccaagaa tttttctgga 2864041 aaatgctgac cggacacatc catcaggagg atgatatggc ggatgggttc cataagcttg 2864101 gaatggccgc tccttcagag ttttccgtta tgatcatccg cataaatggc gagctgactg 2864161 aaaaaatcga acagcagctg caatatttac aggaaacgac ccagcaggtt tacgtgctgc 2864221 tggcgaccgt agattccaat gaacttatta tattaacctc acccaaaaca gatcatcctt 2864281 ttcaagattt aaaacagttt gctttaagta cgcaaaaaca gctgaaggag cggtataaaa 2864341 tagaagacgt ttctatcgct tttggcggaa tatacaactc tatttctttt gtctcccgct 2864401 cctatcagga agcattgtcc gtcttaaaaa cgaaggaacg gttcgctgaa gagaccaaac 2864461 atcttttcag cttttctgag ttaggcattt atcaatactt agatgtctta aatgaaaaac 2864521 ggaaacaggc gggccattat aattactcgc tttccaaact ggaacaatat gaccgggatc 2864581 accagtcaaa tatggtagag acgctagagc gctttattga agcggacagc aacgtgaata 2864641 ccgcttccaa gctgttaaat atacacgtta atacgttgaa ttaccgactc aagcggatca 2864701 gccagatcgc tgaaattgat ttgaaaaatg tgaatcaaaa attcaccatc tatttagata 2864761 tcaaacttcg gcacatggat ttgtgaaatt tcacaaatcc atgttttttt attttcttaa 2864821 tcaaacaaag aattttccaa aatatcaagc tacactaaaa atatcacata tacaggagga 2864881 gacagatatg atcatagggg ttcctaaaga gataaaaaac aatgaaaacc gtgtcgcatt 2864941 aacacccggg ggcgtttctc agctcatttc aaacggccac cgggtgctgg ttgaaacagg 2865001 cgcgggcctt ggaagcggat ttgaaaatga agcctatgag tcagcaggag cggaaatcat 2865061 tgctgatccg aagcaggtct gggacgccga aatggtcatg aaagtaaaag aaccgctgcc 2865121 ggaagaatat gtttattttc gcaaaggact tgtgctgttt acgtaccttc atttagcagc 2865181 tgagcctgag cttgcacagg ccttgaagga taaaggagta actgccatcg catatgaaac 2865241 ggtcagtgaa ggccggacat tgcctcttct gacgccaatg tcagaggttg cgggcagaat 2865301 ggcagcgcaa atcggcgctc aattcttaga aaagcctaaa ggcggaaaag gcattctgct 2865361 tgccggggtg cctggcgttt cccgcggaaa agtaacaatt atcggaggag gcgttgtcgg 2865421 gacaaacgcg gcgaaaatgg ctgtcggcct cggtgcagat gtgacgatca ttgacttaaa 2865481 cgcagaccgc ttgcgccagc ttgatgacat cttcggccat cagattaaaa cgttaatttc 2865541 taatccggtc aatattgctg atgctgtggc ggaagcggat ctcctcattt gcgcggtatt 2865601 aattccgggt gctaaagctc cgactcttgt cactgaggaa atggtaaaac aaatgaaacc 2865661 cggttcagtt attgttgatg tagcgatcga ccaaggcggc atcgtcgaaa ctgtcgacca 2865721 tatcacaaca catgatcagc caacatatga aaaacacggg gttgtgcatt atgctgtagc 2865781 gaacatgcca ggcgcagtcc ctcgtacatc aacaatcgcc ctgactaacg ttactgttcc 2865841 atacgcgctg caaatcgcga acaaaggggc agtaaaagcg ctcgcagaca atacggcact 2865901 gagagcgggt ttaaacaccg caaacggaca cgtgacctat gaagctgtag caagagatct 2865961 aggctatgag tatgttcctg ccgagaaagc tttacaggat gaatcatctg tggcgggtgc 2866021 ttaattcaca ataagcttgc agaaagattt ctgcaggctt ttttattttt taaaaggaaa 2866081 aaagagacca tttcacgaat tatgactatg aagttgatca taaaggagga ttcatatggc 2866141 tgttcagcaa tatggcgtgt taaaaggcat agtattagac atgaagcggg aaacagatga 2866201 tgacagtcct catttccaag tcaaaatgct cggtgaagag aatacgtatt acaggtgcgc 2866261 catcaatgtg atgtccagtt ctgaggaatc tgaagtattg tatttggctg acgatcagtt 2866321 tgattcgggc tcaattacca tccttccgaa catgccgtat ggatatacaa ggatcaatga 2866381 agcaaaccgt gaagtggcac tggattatgt gcggggcaat ttgtttgacc cgcgggaaat 2866441 gaagcctttg cctcatgaaa tcacgggacc tgataatgat ttaaatgatt ttattgaaac 2866501 ctatatgaag aaagcacaag atgagaaaac gccggtttat atattcggtt caaaattcgg 2866561 ccctgaacag gctgcagata aaatattcgg ctttaccccg actaacggaa tgcacaatat 2866621 ccatatgaat caagggaatg caatggatac ccgctggaaa aaagacaacg gctcttggca 2866681 tgacgggggt attctgattc agtttgcaga tcagtgggcc gctgtgtttt tagcgttttt 2866741 atcccaatct tggtgtaccg atgaaaacgg aaaccctgtc agagattgtg atcataccca 2866801 aacgtctgcg taagatagaa aaagagactg cggcaagcag tctctttttg ataagattac 2866861 acattttcaa cagtctttag gctgtttggc ctcatatcgc tccaatgcga ttggatatag 2866921 tccaaacaag cttcacgccc tttttgctca tgaacgactg tccagccgct cggcacatct 2866981 ataaaacccg gccataggga atattggcct tcttcattga ccagcaccaa atatgtgcca 2867041 tccgcatttt caaaaggatt tgccattcta tttctcctcc cttatttatt caactcttcc 2867101 aatttgacag cgagaacctt gccgatttga gccagaggtt caggctgaca taaatcttta 2867161 tgacggcagt cgatgtcgat ttgttcaatc tgtccgttaa tataaggctt ccacgagtca 2867221 ggttcaatcg ggtcaaacca ttcaggaatg attgttgatc tgaaaaacaa aacatttccg 2867281 cggaaggttt tcggcttata ggaacctaaa atgccgacag aatttacata cgtattcttc 2867341 aaatttaaaa tgaccgtttc atccaggctc gcaagcgcac tgccgtcacg gcgaagaatc 2867401 tcaatcgccg cttcaaaatc tagcggtttt tcccctaagc tgtctggatc atacccgcct 2867461 aacgccagaa gggcaataag cgcttcctca tcatccggtg cctcttttat aggaaggaag 2867521 tggttcggat aggcgtccag catcaccaac agggatactt cttctccttg attttgcagc 2867581 tgggtagcca tcgcttgaac gacattcccg cccagggacc agcccagcag atggtacggg 2867641 ccttttggct ggaccgttcg gatttgttta atgtaatcgg cagccatgtc atcaagtgtt 2867701 ttcggaagct cctcgcgctg cccgattccc cgtgcctgca agccgtagat cggataatct 2867761 gttcctatat tggtcatcaa accggcataa caccagctga gcccccctgc cggatgaaca 2867821 cagaataaag gaggcttgtc tccgcttgtt cggagcggca gcagaacgtc aagagcgctt 2867881 tggcttgatc ccatttcaag tctttcagcg agcccggcta cagtaggtgc ttcgaacaag 2867941 ttgccgatgc tgagttcaac gccgagcgct tcacgaatgc ggctcatgag ctgtacagca 2868001 agcaaggaat gtccgcctaa atcaaagaaa cggtcatcaa tgccgacacg cggcaagtga 2868061 agcacctcca taaagaggtc acagagaatt tcttcctgcg gcgttctcgg tcctcgtcct 2868121 gtcactgccg ctgcgaaatc cggagcgggc agcgctttac gatcaagctt tccattcggt 2868181 gtcagcggca attctttcat cgtcacaaag gcagcaggca ccatgtaatc cggcagtctc 2868241 tcagcagcat atctgcgcag ttccgccgta tcaaatgttt cttccgaagg gatgacataa 2868301 gctgctaacc gtttatctcc cggctgatcc tcacgaacga tcactgccgc atcttcaagc 2868361 tgcggatgct gaacaagcgc ggcttcaatt tctcccaatt caatccggaa tccccgaatt 2868421 ttcacttgat ggtctgcacg gccgacatag tcgagagaac cgtcagcgcg gaggcgggcc 2868481 acatccccag tgcggtacat ccgggtgcct ggaggaccga acggatcagc tatgaagcgt 2868541 tcagatgtta aaccaggccg gcctagataa cctcgtgcta accccgctcc tgatacatac 2868601 agctctccgg caacacccgg cgggaccggc tgcaggcgtt catccagcac gtatacacca 2868661 agatcgggaa tgccgcagcc gatcaagctg tttgcccgta aagctgccat gcttcggtct 2868721 aattcgatat agctcacatg caccgtcgtt tctgtaatac catacatatt gataagctgc 2868781 ggtctatttt cagggtggcg gttgtaccaa tcctctaaac ggctgagttc aagcgcttct 2868841 ccgccaaaaa tgacatagcg cagactgagt gcctgtccga gatccggctg ttcccgttcc 2868901 gcctgcataa actgatagaa agcagacggt gtctggttca gaacagtcac cccctctttg 2868961 acaagcaggc gcagaaacgc ttctggcgat ctgctgacgt ggtgaggcac gattacaaga 2869021 cgtccgccat gcagcagagg accccagatc tcccacaccg aaaaatcaaa cgcataggaa 2869081 tggaacatgg tccagatatc acctgagctg aaacggaacc agtgctcggt cgctgcaaat 2869141 aaacgtgtta cattttggtg aggaatcatc acaccttttg gaacacctgt tgagccggat 2869201 gtataaatga catatgccgt attcaaaggg gaaagcggct gagtcctatc cttatttttt 2869261 ggattacctg cagggtacgt gtttagtttc tctgccagct cgggatcatc cagcacgatt 2869321 ttcggcacgt tttcaactgg cggaatgtga tttgcagctt tagtgttcgt catgataaac 2869381 gcaggctgtg catcttttag cataaaagca attcgatcag ccggataatc cggatcaaga 2869441 gggagataag ctgccccggc ctttagcacc gccaataggc cgacagccat ttccaacgat 2869501 cggggcagtg ccaatgccac aaattgctcc ggcccgacac cttcactaat catcattcgg 2869561 gcaagccggt ttgctctttc attcagctct gcatagctca gttcctgatt ttcatataca 2869621 acggcaatgg catcaggacg taaagcagcc tgcttctcaa attgctctgg caaacatgcg 2869681 tgcggaatct tttcagatac actttgccaa tcagtcacca tgctgctgtg ttcctctggc 2869741 gcaagaatat ccagatttcc gatttgctcg tcaggatcag actcggcagc ctccaacagg 2869801 cgcatcaatc ggtcagcaag agcctgagca gtttcccgtt tgaaaagatc agtgctgtat 2869861 tcaagcagtc cttccattcc gtttggtgtc ccgtcagcaa ggcgatcttc actaatttcc 2869921 agcgtcaaat caaacttggc agaaccgaca ctgttgattc gcaggctgct ctccatatca 2869981 ggaagatgca gttcagcgtc cggtgtgttt tggaacgcaa gcatgatttg gaataaagga 2870041 tgcgtcgcac gcgaacgagc cggattgagc acctctacaa gtctctcaaa cggcagatcc 2870101 tgattgtcat aggcggccag attcacttcc cgtactctgt ctagaagctc acgaaagctt 2870161 gggtcaccgg acgtatcagt tctgagcacc aatgtattaa tgaacagccc tacaagatcg 2870221 cccagcgcat catcattccg tcccgcgatc ggactgccga tcggaatgtc ggtgcccgcc 2870281 ccgagccttg tcaataaagc ggcgagaccg gattgaagca ccataaacag gctcacccta 2870341 tttgcgcgag ccagctcctg caatcgcttg tgaaactcgg gctcaatacg aaaatgaatc 2870401 gtatctccat catgactcgg ctcagccgga cgtgaataat cggttggcag ttcaagctga 2870461 tcaggcaggt ttttcaaggt ttctttccag aaagcaagct gtccggcaat caagctattt 2870521 ggatcatcct cgtttccaag cagttcttgc tgccaaagcg catagtctgc atactgcaca 2870581 gcaagaggcg cccattcggg agatcgtccg tggcagcgag ccgcataagc tgtcccaagg 2870641 tctctggtca gcggtgttaa ggaccagccg tccccgacaa tatgatggac gagaagaagc 2870701 agcacgtact cgtcaggacc gatcacaaaa agctcggcac gaaaagcagg ttcagctgca 2870761 agatcaaagc tgtagcgtac agcttcggca agccgatcag aaagctcctt ctcagcaatt 2870821 tcagtaacat gtaactcggg acaggctcga tcggcatcta aaatatgctg ataggatgtc 2870881 ccctgtgatt cagggaagat cgtccgaaga ctttcatgac ggcagacgag gtcataaagt 2870941 gccgctttca gcaatccttg atccaactca cctgacaaac ggacagcaac cggaatatta 2871001 taagtaggac tcggtccttc cagacaatgc aggaaccata gccggcgctg ggcaaatgag 2871061 agcgggatct tttcaggccg ctcagctctc tgcaaagcgg gacatgcact ctgcgccaaa 2871121 tcaagatggg cagcgagtcc ggctactgtc ggttcgtcaa agagcttggc gataccaagt 2871181 tcggctccca ttacctcgcg aatgcggctc atcagacggg ctgcaagaag agaatggccc 2871241 ccaagctcga agaaactgtc atcgataccg acgcgtgcca aaccgagaac ctctgcaaac 2871301 aagtcacaca atatctcttc ctgaggagtc cgcggggccc gatcactgac agatgtgctg 2871361 aagtctggtg ccggcagtgc tttccggtca agcttgccat taggtgttaa cggcagctcg 2871421 tccatctcca caaacgccga cggtaccata taatcaggaa gactagcccc catataacga 2871481 cgaagctctg cagtatcaat agcagcatca gcgactacat aagccgccaa tcgtttgtct 2871541 cccggctgat cttcccgtac gacaaccgcg gcctgttcaa tgtgcgggtg attggcaagc 2871601 acggcatcaa tttctccaag ttcaattcgg aatccgcgaa ttttgatttg atgatccgcc 2871661 cgcccgatat aatccaaaga cccatcggcg cgccagcggg cctggtctcc ggtccgatac 2871721 atccgagttc ccggcggtcc gtatggatct gcaacgaagc gctccgccgt taaatcagga 2871781 cgatggaaat aacctctggc caagccggtt cctgcaatat aaagctctcc gacaacgccc 2871841 ggcggcaccg gctgcaatcc attatcaagc acatacacct gcgtgttcca aatcggtttc 2871901 ccaatcggag gaacgccctt cagcccttct tcaagaaaag ctgcggcaga ccaaatcgtt 2871961 gtttcagtgg gaccgtataa gttcgtgact gaacaatgaa ggtcttgaag ttcctgcaaa 2872021 agaccgctcg gcagcgcctc gcctcctaca agcactctaa gcccccgaag tttctcaggt 2872081 tcactcgtta ccaaagcgtg ccacagtgtc ggtgtcgcct gcataatgtt aatatcgaaa 2872141 ttttcaatca tttgagctaa tgcctgcggc tcacggatcg tttctttctt tgcgatcacg 2872201 atttgcgctc cgctaatcag cggaagatat aactccaatg ctgaaatatc aaaagcgaca 2872261 gtcgtcacag ccaacagcct gtcttcttct cctagagaaa atgcctcctg catagacagc 2872321 agaaaattgc ttaagctttt ctgtgtcaca acgactccct tcggtcttcc tgttgatcct 2872381 gaggtataga tgatatacgc aggatggtca agcgaaaccg atacatcctg attttccggc 2872441 gaatagcgtt ttataatctc ctgtgtaaca gcctgatcaa gcacaagctc aggtacagcc 2872501 aggtcatcag gcagactggc tgctatttcc tcagtcgtta tgatgcatga aggtttcgca 2872561 tcctccagca tgtaagaaat gcggtcggct ggaaactccg gatcaagggg gagatacgcc 2872621 gcaccagtct tgagcacacc aagcattgaa gccaccatct caggggaacg cggcagcgcc 2872681 aaagcgacaa attgctccgg accaatccct ttttcgatca acagacgcgc gaggcggttt 2872741 gcctcttcat tgagctttcg atagttgact tgaatgtcat cacacatgag agcgatacgt 2872801 tctggcgtaa gaactgcctg cttttcgaac atgtcctgaa ggctgaccag cttctcggat 2872861 tttgccgtct cattccattt agaaatgact ttttctttct cctctggcaa cagaagctcc 2872921 atttgcccaa tcagcatgtc ctctccggca gaagccgttt gcagcagctg caaaatacgc 2872981 tgctgatgaa gcttaatatc agactcactg tatacctcgg gattcgcatc aacatcaatt 2873041 cgcagcccgc tgccgtctgt tctgtcatat acattgattg atagatcatc aacaggaccg 2873101 gctgaaagat tatgcgttgt gccccggacg ccggcaaagt cgagaccgta atcaaacggc 2873161 ataagattga tttgagggcc aaataatcta tgattttctc ctatcaattt cagatcgcgc 2873221 ctaagctctt catggcgata cttatgatgt cgccgaatac tgcggatttc ccgggaaatt 2873281 tgctgaatca gttcagaaaa gctcatcgaa gagcttaccg tcagccggag cgggagaagg 2873341 ttcatcacca tagccggtac attcagtgac gcggacccta tccgacccat catgggcagg 2873401 ccgagcacaa catcctcaga gccggtcata cggtgcacat aaacagctga caccgcaatc 2873461 atgacttcat gccagcttcc tgagaaatag cgcgccgctt cttttaacgc gtttacatca 2873521 gacggaggca gatatgccgt atgacgaaga aaactgttag atgttcttgg cgcccgatca 2873581 gccaagctca caacttcagg tgcatctgca aaacggtcca gccagaattg acgatccttc 2873641 tcatactgct ctgatccgcg ataatctgta tcctcctcca aaatggcctg gagagaccca 2873701 aaggaacggc ttttagctgt ttgtcctttt ataagggcag tatatgtact tgccacacgc 2873761 tgggctatca gggaaaaacc gaagccgtcg atcgctatat ggtgaatgcg ctgataccaa 2873821 aagaaacgat caggcccggc aataaacaga gcttcattga acaaaggggc ataccctaaa 2873881 tcaaccggct ttgctaaatc agctttcatc cagtttaatg ctgttttttc cggatcaggc 2873941 tcagagctga cgtcaatgac gtgcagctgt acatccggag acgggtttat catctgccaa 2874001 ggcccgtcca tattttcacc gaagcggaca tgcagcgatt ccgcttcctt gatcacgtgc 2874061 cgcaaagctt cttcaaaaag agcaatattg actggtccat tgatttctat atattccgct 2874121 gtattgtaga ttggattgtc cggatcaagc tgctgagcaa accatatgcc agtttgcgcc 2874181 ccggtcaaag aatattgaag atcttttgta tcaggcatcc gtttgtttac cctcctttta 2874241 taaataatcc gcgtttggca gcacttgctg gctgcgagtt gtgagcaatt tctgccattc 2874301 ttcgatcgtt gggcgttcag ccaattccac gaaagtcacc tctgcccctt cacggcgcca 2874361 ttgttccacc aatgtcatga tccttaccga atcaagacca cgatcgagca aatcctcttg 2874421 atctgtgatg tcttccggtg tttcttgtag aagctcagca atttgtttac ggatattctc 2874481 acatgtaaac acgttctttt tgccagtgtt tgctgacgtt ttttgaacgt ctgccggcgc 2874541 attctgcagc tgatcaagaa gactgtcagt catcacggta aacgcacagc gtccagccgc 2874601 atattccagc gccatttgat gtttttctaa tgaaaaatca gcaactgcat ctcccacaaa 2874661 aaaggcttta atatcctcca taaatgcttc acatgctgta acaagacagc cgatatgggc 2874721 gtaaattcct gtaatgatca gctgatcgcg tccctctttg cgcatcattt caagcagatt 2874781 cgttctctta aacgcgctgt atctccattt tgtcagcaca agatcatcat cctctggtgc 2874841 cagctcggtt ataattttct cctcataagg accgctgttt aatcccgggc cccaaaagtc 2874901 tgtcagcagc gcacggtcat ccggattttg gcttcccggc tgtgcggtat agacaacagg 2874961 aatcccaagc tgaacacatt gattcttcag ctttcgtata ttcgctgaaa gctctgttac 2875021 cggagacgct cccgctgtga aagcatcaac aaaatagttt tgcatatcgt gtattaacaa 2875081 gacagcccga ttcggatcag gcacccatga tactttgttt tgcggcatat cagatgctgt 2875141 cggcatttga tacggctgaa tggcaggtat agccatatga acacttcctc tcaaattgtt 2875201 gttttatttt ttaaatcctg caagaagctt ctcggaaatg gcttcacgga gcgctttttt 2875261 gctgactttt cctactcctg tctgcgggaa ggattcgaca aattcaactc gatcagggat 2875321 tttatatgcc gccagtccgc gctctctcaa aaatgcttta agctctgcgg cttttggggc 2875381 ttcatcccgg ggaataatga acacacaaga tctttcgcca agaaattgat caggcatgga 2875441 gaccattgcc gcatcatgga cagccggatg cgccagcaga tgattttcta cctcttcagc 2875501 cgcaaccttt tctcctccac ggttaatttg atccttcgcc cggccttcaa cgacaatata 2875561 gccgtctcgt gtcagcctga cgatatcacc cgtacggtaa aaaccgtcct cagtaaatga 2875621 agcggcgtta tgctcttctg ccttatagta acctcgaatt gtatacggcc cccgcgtcag 2875681 cagatggcct gtttcaccag gttttacgtc gcgatcatga tcatcccaaa cacgcatttc 2875741 atcatatgga gacatcggtt ttccttgggt gttgacaatg atctcctcag gatcatccaa 2875801 tctcgtataa ttgacgagac cctctgccat tccgaacacc tgctgcagcg tgcagccgaa 2875861 aacagctttt accctgcgcg cggcttcagc actaaacttg gcaccgccga cctgcagcac 2875921 ttgaaggctg gataaatcat cacggcgtga ggatgccgca tccatccata ccatcgcaag 2875981 aggcggaaca agagcggtta tcgtgacctt ttcccgttca attaaaggaa atgcgtcatc 2876041 tggacttgga gaaggagata ataccactct tcctccagcg tataatacgc cgagaacgcc 2876101 gggtgagctc agcggataat tgtgtgccat cggcagcgcg gccaagtaca ccgtgctgtg 2876161 gtcgagccag cagacctcca cactccgctt caggctgtat atgtagtcat cgtgggtcct 2876221 cggaatcagt ttcgatagcc cggtgctccc gccagaaagc tggaggaacg ccacatccga 2876281 tgatttgact tcaggcagtt ttacaggttc tgcatgcaaa tcctccagcg gtaaaaattc 2876341 ctctgcctca cctgcgacaa tgatgttttt caaagtcggc agcttgcttt gaacctgtct 2876401 ggcaagcgaa cggtagtcaa aaccggaata agcgtcggga atgatatatg cagccgcttc 2876461 agcaaactcg caaaaatatg taatttcact gcttcgatga gaaggcagtg cgaagactgg 2876521 aagcgccccc agacggaaaa gcgcgaaaat gacttcaaaa aactctttga tatttggcaa 2876581 ctgcaccaca acacgatcca tctgttgaat gccgagcttt tgaaatccgg cagccaggcg 2876641 atcagccctt gtgtcaagct ctcgatagct ccaatgggtg tttccgcatg taatggcaat 2876701 gcgatcacca tatttggctg cccggtccct taacaaatct ccaaacgtct caccggccca 2876761 gcagccgttc tttcgatagg tctcagctaa ctcatcaggc caaggcgtaa atcctttcag 2876821 catgttgtat ccctccagca attcattctg ttcatatgtg atccacgccc attgcccgca 2876881 gcattgtccg aaactttgcg gacgtctcct gaagctcgtc ctcaggcttt gaaccggcca 2876941 caacaccagc tccagcatac aggcggagtg agcgttcttc tgcttctgca caacggatgg 2877001 tcacgatcca ttctccgtca ccggcatcgt cacaccatcc gaccatgccg gtaaagaaac 2877061 cgcggtcaaa tggttcaatg ctgagaatcg cttctcttgc aagatcagtc ggtgttccgc 2877121 agacggctgg cgtcgggtgg agcgccgccg ccaattcaag tgcggttaca gacgggtcgg 2877181 aaagctctcc cttaatcacg ctggacaggt gccacatcgt ttccgttttg atcagtgaag 2877241 gcttctccgg aacctccagc gtccggcaga aaggtctcag cgctgccgca accgcgtcag 2877301 cgacaaccgc gtgctcatga agatcctttg cggaagaaag caattcagct gcccggcgct 2877361 ggtcttcaac aggatcatta ctgcgcggtc ttgagccggc taatgggttg gaaacgacct 2877421 gtgttcccat ccttgaaacg agaagctccg gacttgctcc gagcaatgtt ctgcggggag 2877481 acgtttcctc ctgactggac acgtctgcgg caaacgtgta gccatgcgag ttatgctgag 2877541 ccagatggcg aagcaattca tccgtctgaa tcggttcagg cgatgtcaaa tgcagcgatc 2877601 tggacaggac gattttgctg agtgttccat cggcaatgcg tgccagccct tgttcaacac 2877661 catttttata atcctcaggt tcaggaacag gctttatgtg gtatgtatgc ccagcctgct 2877721 gttccttttc ctcatgatca aattgaagcg gtcctgacca gcgcacttct tcaggtacaa 2877781 cgagccgcgc tgcttttact tgatcaaaag gaacggcccc gacaacaagc ggccggcttt 2877841 gccctgattg ttttgcctga cgtaacgcct ctgcaattcg gccagaaagg gtttccattt 2877901 ggttttgccc gtctgcctcc ggtacaattt cacatatgcc tttcgctaac agtacacgat 2877961 gaggagacgc taagaaaaag gcgcccggct gatattcatg aagcaaatgc tccgcttttg 2878021 tttctgttat aacgttttga tccaacattc tcatgaacct cctttaaatt cagttacacg 2878081 cctaaggtcg cgccgccatc tacgcataaa ttatgcatcg taatatgccc tgcctggcca 2878141 gaaaccaaaa agagcaccgc atccgcaata tccgaaggct tggctagttt tttgagcggg 2878201 atccctgttt taaatgtctc aagtgatcct tttatgactt gctccgctcc attctcgtcg 2878261 gcccataatg accactgcat gtctgtttcc gttgatccgg gagatacaat gttgcagcga 2878321 atattgtatt ctgcaagctc aaggccaagg catttcgtaa acatcacagc cgcagccttt 2878381 gaagacgcat atgccgccat agatgttctt ggtacaccgg cagcattcga tccgactgtt 2878441 acaatcgaac ccgatcttcg gtccatcata tatttgctga ctgaacgcga ggcgttaaat 2878501 acgccagtcg aattcactga gaacgtcgcc tcccattcct catcgctaag cgaatggatc 2878561 agtcccgggc gaaggacacc cgctacattc actaaaatat caatcggccc catttcacgt 2878621 tcgatgcgcg ccgtgatctc gtcaatcgcc gcgctgtctc tcacatccgc aggaaaagct 2878681 tctgcatggc ggccttctgc tttgaggctg ctcacaacct tttccagctt ttcaggatta 2878741 taatcaactg ccgcaatatg tgcgccttga ctggcaagcg tccgcgcaac agcttcgcct 2878801 attccttggg cagcccctgt tataaaagca atttttccct ctataccctt tgcattcata 2878861 tcatcaattc ctttcttcgc tctaaatgcc aaacagacat ccagcgaaaa agactgctgc 2878921 gccttgaaaa acgcaatcta ttgataatga ttatcattat caattataaa aataatcata 2878981 tccaaatgtc atgtgacagt caaatataat ttcagtgaca aatatttttt taaaggcaag 2879041 gctgagtatg tctcagccca ttgatagatg cggtccgtca gggtgaagcg caaaacgcag 2879101 cgccctgctg accaaaacag gaagaactga aatatgtcct tctcctgaaa actcgcaaaa 2879161 ttctgcccgt ataccttgtt cagataaaac ggccagccgc tcataaagct cccttgcatt 2879221 atcattcatc cggcttttat gatgctgctc taattctcct gcggcaagca ggatattgat 2879281 aggctgattg tttttcttgg tgagagagac gaaatggtcc gttttcttga gaataaacgg 2879341 tttattccaa tgaatggacg gacttcccgc gatatacgtt tgaaacgcat cgggctttgt 2879401 tagcagcacc tgcagcacga aaagccctcc gagcgaatgg ccaaagattg tttgtctttt 2879461 tttatcaatc tggtaatctc gttctatctc cggttttaaa tcctcttcaa taaatctgaa 2879521 aaagccctcc gctccgccat gctccggcca ttctctgccg tcgggccttt ccggcagctt 2879581 cgattgggct gttggcattg taaaatcccg gtggcgtgct gaggagaacg gctccgctgt 2879641 ctcatagcca atgccgacga tcactgcagg gatcaccccg gttttttcgg gtcggcgtcc 2879701 ctgtattcga acggcttccg tcatcgttcc gaagacagaa ttggcatcca gcagataaat 2879761 cacaggataa ccagcgggtg gcggcggcgt actaggtttc gagataaaaa tgtgataggt 2879821 acggttttca ttgcgtgaag acatcatacg cacttccgta ccaggaatcg taaatgcgtt 2879881 tgatgtcccg ccatttgtcc ggtctgttgt ttgttctttc atgcagtacg acattcctct 2879941 ccttaaacta aaccgcaatg tatgataatg attttcacta tcaactagac acctcaaata 2880001 ataggttttc ttccaaagaa agtcaacttt ttcccgaata aaaaaggcac cttgatcaaa 2880061 taaggtacct gcagactatc aatatggaag taaaaaccta ataaagatgc gtattgtcct 2880121 atttgaaata gaaccttaat cccatgtaaa cctttgattt tgccaagggt cgcctctcat 2880181 gtgatagcca ttccgctccc aaaagccagg gtgattttct ttcgtaaatt ggatgccgcg 2880241 cagccacttg gcgcttttcc aaaaatacag atgcggaaat acaccccgca gcggaaagcc 2880301 gtgttcaggg gttaaaggtt cgccattatg cgcataagcc agaagggaag tttccgctaa 2880361 gaaatcatca agcggcagat tggtcgtcca gccctcttca gcatgtaaaa tgacgtagcc 2880421 cgcttcttct tttacacccg ctttttccgc tatatcacaa gcccgcacgc cttgccacac 2880481 attatcaagc cttgaccatc ccgtgacgca atgaatgtcg tttttcgatt cataccgtgg 2880541 aaaggctttg acatcttcaa agcttagcag catcggatgg tcaaccaaac cgtatacttg 2880601 aagattccat ttcgtcatat cttcgtaata tgggacatct ccggtatgaa gcacaggaaa 2880661 tgaagtggtg acgttttgat ttggcggcac tcttccagat tgatcggact gtcttgtttt 2880721 tccgaaatac atatgggcct cctttttgtt aacctaattt aaaatcatgt tgacaatctt 2880781 tttgttcttt attactctat gattgtgtat gtcaacctaa gggggaacaa cgatgaaaca 2880841 acgtaaactt cgtgcgggag atatggcgct gattggcatg ttcgccgcac ttatggctgt 2880901 cggggccaac attacatcag tagcaccctt tttacaagta gccggcattc cgctttcgat 2880961 gcagccgttt ttctgtctct tggcagcttt gcttcttggc agcaaacggg cagcgattgc 2881021 catgattgta tatgcacttg tgggattggc cggagcgcct gtgtttgctc aattttcagc 2881081 aggcttcgca ccgtttgcag ggaaaagcgg cgggtttatt atctcataca ttccggcagc 2881141 atttgcagcg ggatggtttt tagaacgaaa cattcagcca agtaaaattc gatttctcat 2881201 tgcttcactt atcggaacgg cgatcatgta tctcatcggc actacctata tgtatcttgc 2881261 actgaagctg tggattcata cgccagtgag ctacggcacg gcttggggct ttatgatttg 2881321 gtttatggta aaagatacag cgctggctgt gatactgtcg tttatcgcac cagcaatcta 2881381 ccgctctatt cataaagcaa ccggctttaa cagaaatcac atatcatcta cgtaaaaacc 2881441 gttctattgg acggtttttt tatcataacg agaaaaggct ccccagtaaa ggggagcctt 2881501 tttcctataa aacaagcgct gcaatccagc caaagatgac aagcggaata ttataaaata 2881561 taaatgtcgg cacacaagta tcccaaatgt ggtgatgctg gccgtccgca ctcaaacctg 2881621 aagtcggccc aagcgtactg tcactggcag gtgaaccggc atcgccaagc gcagcagcag 2881681 ccccgataat cgcaatcgtt gccatcgggc tgaatccaag ctgcatgcat agaggcacga 2881741 aaatggttgt gataacagga atggtcgcaa aagaagatcc gatccccatt gtaattaata 2881801 agccgacaat gagcatcagc aatgcgccca aggactgact gtgtccgata aaaccagctg 2881861 acgttttgac cagtgactcg acatctccgg ttttcgtcaa tacgtttgaa aatccggctg 2881921 caacaagcat gacaaagccg ataaaggcca ttaaaaccat tccatcagta atcagtgagt 2881981 ccgcttcatc acgcttcatc acaccgctga caaacagaac aatcagacca gcgagcgccc 2882041 ccataatcat tccttctact cccaaagtct gagataagta aagctggacg ccgagtgaca 2882101 caacaatggc tagaaccgcg ataccaatac tttttctcgt atatggcgat gcttctgcac 2882161 ctgaaatgtc ttttgtttca tattgtttcg gtttacggta tacgatcact gataaaataa 2882221 ggccgacaac catacctgca actggaataa tcagtgcgta cggaatatca gcaagcggaa 2882281 cgtttaaccc ggcatccgcc atattgtcct tcagcatgcc ttggaagatt tggccgaaac 2882341 cgaccggaag caaaatataa ggagccgtta agccaaatgt aattacacac gcgatcagac 2882401 ggcggtccat ttcaagttca ttaaagattt tcaaaagcgg cggaatcagc accgggataa 2882461 acgcgatgtg aaccggaacg acgttttgcg aaaaacaaga tacaattaaa ataatcagca 2882521 caatcagcac cttagacagt gctttttttc gagaatcttc tttatttccg attaatttaa 2882581 cggaggcttc caccattgcg tccggaagac ccgttttcgt caaagcggcg gcaaacgcgc 2882641 caagcatggc atagctaact gcaacggtgg catttccgcc gagaccgtct gtgaaagctt 2882701 taaccgtttc gccaagaccg agcccgcctg ttaacccgcc ggccaaggcg cctataatta 2882761 atgcgataac aatattgaca cgcagcaggc ttaatacaag cataagcagg actgcgatga 2882821 cgactgcatt catgatgata cccctccaaa aatcctttag tttgctaatg tagtagataa 2882881 ataaagtacg aacgtatcgt atcataaccg atccacttta gtcaactaaa gatttcggaa 2882941 gaaaaaatcc ctgccgcatc atacagcagg gatttttcat tactcgtttt tatcttcttc 2883001 caatgtaaat cgctccgcaa gtgtagccag tgttcttgcc ataacgccag tagccccggc 2883061 cggtccgaag caggttgctt tattggcagt cgctgtgcct gcaatatcaa ggtgaaccca 2883121 aggtgttgac tcagcgaatt caccaagaaa cgttcctgcc ataatcgcat gtccctcgcg 2883181 tcccggtgaa ttgctgagat ccgccatttg gctgcttttc acgcgttttt tatccttctc 2883241 tgttatcggc agctgccaga tcgcctcgcc gcactcttgt gcagcatcag ctacctgctg 2883301 gtaaaagctt tgatcatttg tcattgcacc ggttgtttct gttcctaatg ccacaacgac 2883361 gccgccggta agcgtagcta catcgacaag aactgatgcg ccatgctgtt tcgcgtatgt 2883421 aatgccatct gcaagcacta gccttccttc agcatccgta ttaaggattt ctattgtttt 2883481 tccgcttaaa gatacgatca cgtcatccgg cttcatggcc ccgccggaga tcatattatc 2883541 ggttgatgga ataacgcaca gcacgttttg ttcaggacga agctctccga tcgtttccat 2883601 agccccgaga accgcagctg ctcctcccat atctgatttc atgccaacaa ttccagattt 2883661 cgttttaatg gagtagccgc ctgtgtcaaa ggtaattcct ttcccgacta gtccgacgac 2883721 gtcttcccat tcctttttgc cctgatattt caacacaatc attttcggcg gttcggtgga 2883781 gccttggttt accgcaagta ttccgcccat accgagctct tccatctctg atttctccaa 2883841 tatctcacac tcaaaatcat atttcgccgc aagctcttca gcatacgaag cgaggtcagt 2883901 cgctgtcagc atgtttcccg gcatattcac aagcgttcta gccgaatttg tcccttgtcc 2883961 gtatgcctgg ccgacgcgaa gccctgcctg cacttcctgt gtatcttcat ctgttacaac 2884021 atacacggct tcaatttgtt tgtcaggctc atttgattta tgcttataat cctgcacctc 2884081 ataggaagca agcaggcagc tctcagctaa agcatgagcg gcatcggctg gaggcacgtc 2884141 ttccgaaata aacgtatcaa gcagaacagc agtttcttgt tttcgatctt tatgaatggc 2884201 ttgaaaaaca tgagcaaaac gttccttcgc ctgttcaaac gaataatttg cttctctccc 2884261 caggccaacg aaataaatcc gtttcatacc cgcagaagat ggagggaata cttttgatac 2884321 ttgattcggt ttcgcagaga catcaccctc ttttaaaagc tgtgtcagat ggccttcgag 2884381 catttcatca atttccaacg cttttcctgt cagctggctt ttttgaaaaa gcccgacaac 2884441 aagggtttct gtatgctctg attgttgaac cgcataaaac atgaggctta cactcctaac 2884501 gtaatgggta tttgtaatga acaatggtat aataggaaaa acattctttc cactatactt 2884561 attttaacaa acaacagtct aagacttgct tttttctttt gaaacacgaa ggatttttca 2884621 aatagaaagg atgtcgccga tggaactttt aacgaatttt cctttattat caagcctggc 2884681 cgcaattatt tttgctcagg tcatcaaagt gcccatacag tttatcgtgt ccagaaaact 2884741 ggactggtcg ctggtcacaa gcacaggcgg catgcctagc tctcactccg cagcggtcac 2884801 tgcgctttct acaggcgtag ccttggagca tggattagac tcctcactct ttgcggtttc 2884861 cgccattttc gccgtcataa ccatgtttga cgcaactggc gtcagacgtc acgccggtga 2884921 gcaggcaaca gtcattaata agcttgttat tgattttaac cgtttcgtaa atgaagcgaa 2884981 ggacttccct aaggctgcag agaaagaaaa gcaaaaaaag ctgaaagagc ttctcggaca 2885041 tcagccgatc gaagtctttt tcggaggatt aacaggtatt ttactgacat tggtactcgc 2885101 ttactttttc atgtaaaaaa aacgctcctg ctttcgctgg agcgttttat tctttcaccg 2885161 ttttatattg atttctgaac acttgcaaag attttgtttc attgagcttc tcaagctcat 2885221 cctcggtaat ctttcccgtt ccctttttaa tcacatatac atcaagggtt tttttgcccc 2885281 attcattgta tacatctttg actgtctcaa agtacagatc aaggcggttt cccttaatag 2885341 ctgatcctgt gtcggccaca actccgagac cgtagttcgg aatgaataaa attgttccga 2885401 tcgggaaaac ggacgggtca gcagcaaccg tggaatataa atcccgtttc actttcacac 2885461 ctgaatatgt aagcccgtat aatggatcac cgggattttt gcccgtcgac tcagctcctg 2885521 ctgtgtagcc tgttgctgtt actctttgga ctggatattc atcccaatca aatgcctctt 2885581 ctaacggttt tgttttatcc tcagccgcgg acgtggtttg tgtttgtttc tgctgcaatg 2885641 cttttaatct cagtcctgca tgcttcaagt gcttttcctg atgttcctgc acccattttg 2885701 acaagtcctt cgcttcaatt cctgacactg ataaaaatgt cgtgccaaat gcaagcagaa 2885761 ataaacaggt catcagcaaa cgtctgatca tattcaacat cattcacctc tcctccgaat 2885821 cattgttccc aagtggagag agcattattc aaaatggtga atgagctgaa cgcataaaaa 2885881 aagctttctt tagaagaaag cggcatttaa aacatttgat atcctctttt tctaagcatg 2885941 ttgatcgcta taccggacac gatggcgccg gccaaaccgc tgactaaaat cagcacatca 2886001 gcagccgcta atgataagac acgatgaaac aggctggcaa aggattctcc cggcgactgg 2886061 acatagctga tcagcttttc tttgctgata atgaaaaggc atacaattgg ataaatcaca 2886121 gccataatcc aagacattct cagcagcatg tttaataaga aaccgattcc aaaaaacaag 2886181 acaaaaaaca aaacaattga gatgattacg actggcagac taatcaacct attccacccc 2886241 cctgcgttgt ttttagtgta acgcgggggc tgaaataaag tcaacggctg gaaaaagaat 2886301 gactgtcttt tcctgtcccc tggcaagacg gacaagtctc tgaaccgccg agaatcaatt 2886361 gaaaatatcc tttccctgaa caaaatgggc atgcatgtga agcggttgtc gttgcagttt 2886421 tcatctaatc atcacccttt ttcttaattt tctgataata taccatatca agctgtcaac 2886481 aataaagtca gatcatgtga caaatctttt gatgtaagcg gaaacatact tgttttcctc 2886541 tcgttctctt tttattttgg cgttttttaa taaagaaaac ccgcttccgc gggtttttag 2886601 aaaaacttga acttgccttt tttcaatgtc agtccgagtc cgccaatcat aaacagtgag 2886661 cggttatcaa tgactttttt cataaacgaa gcgggcgtgc ctttcagctt tctgccataa 2886721 acaaccccaa ccgcgttatg ctcgccaaga gaagccactg ttcccttaat gtccggcttg 2886781 aattcctcaa gctctccgcc tttaataagc ctgccaaggt ttttagcgac cgttatgccc 2886841 tgctgcattg caatttgcgc agtcggcgga tacgggcgct ctgtatcttc attcataaac 2886901 agcgagctgt cgccgagaat aaagacattg tcatgtcccg gggcgcggag atcagggttg 2886961 actttgactc ggccgcgcat attctcaaaa ccggcttcct ccacaatcgg atggccgcgg 2887021 acacctgccg cccatacaac ggtttgcgat ttgatctgct ctggttcttc atcttttttg 2887081 ccgactctga ctccttctgg tgtacattct tgtacagccg ttccgatctt gaactcaact 2887141 ccgttttcct caagataatg tacggcgtaa tcaacaagtt ccggatcaaa gcccggcaaa 2887201 acggtcggcg ctgcttccac acaaatgatg cggacaaggc ttctgtcaac gtcatattcc 2887261 ttacagagct ccggcacgcg agcagccagt tcgccaagaa attcaattcc cgtaaatccg 2887321 gcaccgccaa caacgatcgt taacctgtcc ggccgttttt ccgcttccgt attgtaagtc 2887381 gcaaactgca gctcaatatg ttcccgcagc aggcgcgacg tgttgatgtt ggcaatcgga 2887441 aacgcatatt cttttaagcc tttaatgccg aacgtttcag gcacggcgcc gagcccgatg 2887501 actaaataat cgtactgcaa ttctccattc gcaagcacaa cttttttctc atcaattttg 2887561 attgccttta cggtatcctg tacaaaattc acccgtgact ggttgattac atcttttatc 2887621 tgataacggc agcggtcatg atggagcgta cccgcgctcg cttcatgcat ccatgtcgtt 2887681 tcataatgat aattgtgttt atttacaagc gtaatgtcag catcattcgg cccgacatac 2887741 ttcgtcagcc ttgtcaccgt catcaatccg ccatatcctg cacctaaaat cacgattttg 2887801 ggcttattca atgccatcac atccaccttc tctttttttg cttttgttag acccataata 2887861 aaatcatcat ttgtgttagc ttcagcttat tggcgggatt ttatgaaata tattgaaaag 2887921 ttttttgtga agtccttacc cgtagcacta ttatcatgtt tatccggctg gcccaagaaa 2887981 cattcagaaa aagatcattt catttggtta ttatcgtagc ggcctgcgga aatattttca 2888041 agaacggatg ggcacgttag atccttacga ttttttctgc tgactcgtca atttgaacgg 2888101 caatatggta taattaataa caattttcat ttaggaggca attttcgtat gcgagaggat 2888161 acaaaggttt atgatattac aattataggc gggggaccgg tcggcttatt caccgctttt 2888221 tacggcggga tgagacaggc aagcgtcaaa attatcgaaa gcctgcctca gctcggcgga 2888281 cagcttagcg ccctataccc tgagaagtat atatatgatg tagcgggatt cccgaaaatc 2888341 cgcgcgcaag agcttatcaa taacctaaaa gagcaaatgg cgaaattcga ccaaaccatt 2888401 tgtctggagc aagcggttga atctgttgag aaacaagcgg acggcgtgtt taagcttgta 2888461 acaaatgaag aaacccacta ctctaaaacg gtcatcataa ctgcaggaaa cggcgcattc 2888521 aaaccgagaa agctggaact tgaaaatgcc gagcagtatg aaggcaaaaa cctccattac 2888581 ttcgttgatg atctgcaaaa attcgccggc agacgcgttg cgatccttgg cggtggagat 2888641 tccgcggttg actgggcgct tatgcttgag ccaatcgcaa aagaagtatc gatcattcac 2888701 cgccgcgaca agttccgagc gcacgagcac agtgtggaaa accttcatgc gtcgaaggtt 2888761 aatgtcctga caccattcgt ccctgcggag ctgatcggcg aagacaaaat cgaacagcta 2888821 gtgcttgaag aagtgaaagg cgaccgcaaa gagattttag aaattgatga cttaatcgtc 2888881 aactacggtt tcgtttcatc tcttggaccg atcaaaaact ggggcctgga catcgagaaa 2888941 aattccattg tcgtgaaatc aacaatggaa acaaatatcg aaggcttctt tgcagcaggt 2889001 gacatttgta catacgaagg aaaagtcaac ctgattgcca gcggcttcgg cgaggcaccg 2889061 acagcagtga acaacgccaa ggcttacatg gacccgaaag cccgcgtaca gcctcttcac 2889121 tcaacaagtc tttttgaaaa taaataataa aaaaaggagc ttgtgtctgc gacacagctc 2889181 cttttttatt tgaagatatt tatataattc aatgcagttc ctacaaccag cgcaatcaca 2889241 agggctgcga ctacccagat cattgccata ataatgcggt cctgaatctt ttgggacttc 2889301 ggtgtttttt cttcgttttg ggccatctta ttcgctcctt tcccatgtcc atgccataaa 2889361 gaaagcctgg tgctgaacga ccaagctttg ctgaacgtat atcattcgcg ttttgatccg 2889421 ctctctaaga ccattcgtta aaactatgat acctaaactc accctgcatg acaagcttcg 2889481 gcacttgcac cacacctgcc agcaaatcat aatgtttgac atcctaaata aaacagagta 2889541 cattatataa ggcgaacatt tcatatatta tacttttaaa tattcgtttt taggagtgaa 2889601 aaccatggaa aacgtatttg attacgaaga tattcagcta attcctgcaa aatgcattgt 2889661 gaatagccgt tcagaatgtg atacatccgt acgtttaggc ggacatacat ttaaattgcc 2889721 cgtcgtccct gccaatatgc agacgattat agatgaaaaa ctagcgattt cattagccga 2889781 aaatggctac ttttatgtga tgcaccgatt tgagcctgag acacgaattg attttattaa 2889841 agatatgaac gcacgcgggt tattctcttc tatcagcgtg ggcgtcaaag atgaggagta 2889901 tgaatttgtc cgccagctgg cagaagaaaa tctgactcct gaatacgtga caattgacat 2889961 tgctcacggg cactcaaatg ctgtcattga aatgatccag caccttaaaa aacatttgcc 2890021 ggacagcttt gttattgctg gcaatgtcgg aacgccggaa gcggtcagag agcttgaaaa 2890081 tgcgggagcg gatgccacta aagtcggcat cggaccggga aaagtatgta ttacgaaaat 2890141 caaaacaggc ttcggcacag gcggctggca attagcagcg ctgcgctggt gtgccaaggc 2890201 tgccagcaaa ccgattatcg cggatggcgg catccgcacc catggcgaca tcgcaaaatc 2890261 aatccgattc ggcgcaacga tggtcatgat cggttcacta tttgccggac acgaagaatc 2890321 gccaggccaa acgatcgaaa aagacggaaa gctttacaag gagtacttcg gctcagcctc 2890381 tgaattccaa aaaggcgaaa agaaaaatgt cgaaggcaaa aaaatgcacg tggcgcataa 2890441 aggctcaatc aaggatacac tgattgaaat ggagcaggat cttcaatctt ctatttctta 2890501 tgcaggcgga acaaagctta acgccatccg caatgtggat tatgtgattg tgaagaattc 2890561 catttttaat ggggataaat attaatcata aaaaaacgcc aagtcagcgg ttctccgctt 2890621 gagttggcgt tttctgctac ttcttcagca aagtaagctt atatttgctt tttgagttta 2890681 tcttccatca gttctgccat ttgttttgca tttggatttt cttcattttg caactgttca 2890741 atgacgttca tataatccgt ttcatttcgg ttctggctta atttatatgc cgcttgaatg 2890801 tcttccacct taatcttaaa tccaacaata cctttcaatt cactttctaa gagttttgga 2890861 gaaagcttat cccataacac aggattgtca cgatgttttt cgtatttctc caacatgatt 2890921 gttaattctt ctgctaattc atctttctct aacatacttg cttttccata catgtggaca 2890981 gcctgataat tccacgtcgg aacattttcg cgcgaatacc aggaagaaga aatataagcg 2891041 tgcggtccct gaaacatcac aagcacatct tcacaggctt caaacgttct ccactgagga 2891101 tttccataag cgaaatgccc cgtaatatag taatgatcgt cttttttatt gaatcctaac 2891161 ggcaaatgtg tggcaattgg ttttccttgt tctgttgtga caaccgtacc aaaggagttt 2891221 tcttgtacaa aattccaaat ttcttcagca tttgtgactt taaaatattt tggaatatac 2891281 atcatcatcc acccttcgaa aaatattata tgagtgtttt agccatgatt aaatccgttt 2891341 gttcttcatc acccatataa aatgagtggg cgccggtctg aacaaacccc attttcttat 2891401 aaaaggcaat ggcattttca tttttttccc acacacctag ccaaatgttc tttttattac 2891461 gttccagcgc aatttctatc gctttattca gcagatgttt gccaagccca tgtttttgaa 2891521 agctgttctt tatataaatt ctctcgattt caagtgattc agcacccatt tcttcagact 2891581 gagcatcatc gatattgacc tttacatatc cagcgatttc atgatcaaag taaataaaaa 2891641 agaattgcga agacatatta gataactctt tttccagctg ctcagtgtta aatgcgcttt 2891701 ctaaataggc tttcatattt tcaggtgagt tctgttcttt aaaagtgtca ttgaatgttt 2891761 caatactcaa ttgttgaagt gtttgtaaat cttcccggct gcattttttc atttttacac 2891821 tcattgttcg gattcagccc ctttatttaa aattcaattg tcttgtgtcc cttttatata 2891881 tttaaacacg gaacacatac tgaccttgtt accattccaa aaatcttctt catcaccaac 2891941 tccctatcgt gattttgttg taaatgcaat aaaatatact ccgcattaaa tatatcgtaa 2892001 ctttgctgta tttacaacaa aaatcaaaca acaaagcagc gtttctcttg ccgaagttcc 2892061 cggaactctc tgcatcattt ccccataata aaaacgcctc ccttaacgat gatttatcgc 2892121 taagaaaagc gtcagtaata gttgctatcc gtttttagtg cttagcactc ttcaggcttg 2892181 cctgcattcg ttgctgttct gaacgaagaa ccgcagccgc atgaagcgat ggcgtttgga 2892241 ttgtcgatgg tgaagccgcc gccgagcatg gattgtttat aatcaatcac ggtgccgttc 2892301 atgatgtcaa ggctttcttt gtcaactaga acagtgatgc cgtgctgatc aaacacactg 2892361 tctgattcac tcttttcatg ctcaaagccc atgccgtaag aaagtccgct gcagccgccg 2892421 cctttgacgc ctacacgcag aaacgcgttt tcttcttcat gctctttcat catatctttt 2892481 atatgcaaag ctgctgcttc tgtaattgtt accgggttgc tcatcattat gaacctcctt 2892541 ttaaaaaccg gttgctgtct tttattataa acatgatcgt tccaattctc aaacaaggtg 2892601 ttttacaaga aatagacacc ctcacaaacg gtttcagccg gccctgtcat cattacatgg 2892661 ccgttatctt tccagtttat caccaaatcc ccgcctgcta aatgcaccgt gatgtcttga 2892721 tttcgctttg atacgccgtt taatacagat gcgactgccg ctgcacatgc tcctgtcccg 2892781 catgcctgag taatccctga tccccgttcc cagacgcgga aatgcaattc ttgttcattc 2892841 acggtttcaa cgaattccac attgatgcct tccggaaatc tcggatcttt ctcaatcacc 2892901 ggccccagtg tcgttaaggg tgcctgttca atgtctgcga tcggaaaaac gatatgcgga 2892961 tttcccattg aaacggcagt gcctgttagt tctacttcac caaatgccat cgtttcattg 2893021 attgtgtgct cttccccgcc gtcaagcata ggaagctcgg attttgtcaa gcgcggttcg 2893081 cccatatcga cagtgaccac attcactttt ccgttttcga cttgaacctc cgctttcaca 2893141 agcccggaga gagtttcaat cagaaaagat gtttcctcaa ccagcttatg ctcatatgcg 2893201 tattttgcga cgcagcgcag gccgttgccg cagtttttcc cttcagaccc gtcattatta 2893261 aaaatccgca ttttaacagg cgcttggtct gatgggcata tcaggatcat tccgtcggat 2893321 ccgatccctg tataaacaga agaaacctga attgcaatct ctgacagttt ttcttctgga 2893381 agctgttctt caaattgatt cacataaata taactgtttc ccaggccgtg cattttggta 2893441 aatcgaaatg agttcatagg tgcctccaac tttttttctt tttcttagta taaaagctat 2893501 tataagcgga cacaatacaa ttatcccccg tttttcatac ataaaagctc cttgcactga 2893561 cgcaaggagc ttttatcgtt tatataaaca tgccggcaat ggctgcgctg agcagattgg 2893621 ctaatgttcc tgcaagaaca gccttcaggc cgagacgtgc gatatctgaa cggcggctgg 2893681 gcgctaaacc gccaagcgta ccaagcataa tcgcaattga tgaaaaattg gcgaatccgc 2893741 ataacgcgaa actgataatg gtagcagttt tcttagaaaa ctcgccgatg tgcgaaccga 2893801 agttagaata agcgacaaac tcattcagca ccaatttctg gccgatatag cttcccgcct 2893861 gcaatgcttc atgccaaggc acgccaatca aaaaggcgat aggagaaaac acatagccga 2893921 gaatggattc taatgttacg ccttttaaac cgaacaagcc gaaagccccg ccgagaatac 2893981 cgtttactac agcgattaac gcaacaaacg caagcagcat cgccccaaca tttaacgcaa 2894041 tttgcagtcc tgttgacgct ccctttgcag ctgcgtcaat gacattggct gcgccttcgc 2894101 cttcatccat tttgaaatcg ctttttacgg tttgcgtttt ttccgtttcg ggtataatca 2894161 atttaccaaa gactagtcca gctggagcag ccataaagct ggccgccagc aagtactcaa 2894221 tcggaatacc gagaagcgcg tacccaaaca aggtagatcc cgcaactgcc gatagaccgc 2894281 tcgtcataat cgtaaacaac tcagagcgcg tcagcccggc aatcaggggt ttgatcacta 2894341 acggagattc tgattgtcct acaaaaatat tggcagcagc cgccagagat tccgttttgc 2894401 ttgttccaag gagcttcgac aatccgccgc caatgacacg gaaaacgagc tgcatgattt 2894461 tcaaatgata taaaactgca atcagtgctg agaagaaaat gataacgggc agtacactta 2894521 atgcaaatgc cggactgtct ccgaccttta gaagcggtcc aaaaataaaa ctgatgcctt 2894581 cattcgcata gtcaatcaga agctgtacac ggcttgaaaa ccataaaaaa acagcgcgtc 2894641 ccgcttccca tttcaacacg atgtatccaa acgccacctg tgtgcataaa ccaacgatga 2894701 cggttcttat cttaatattg cttttctttt ctgaaaataa aaacgcgata gcaatgatcg 2894761 caactgcgcc cagcagcccc cacagaacat tcatgaatac tcgtacacct cttaaatttt 2894821 atttaaaaaa atatctttta tacgataaca ataatatttt ttgatgtcta cacatttttt 2894881 tagttctttt gtacggcaaa ataaaaaagg gcctgtccag gcccttttct ttaaaacatt 2894941 ggattttctt caataaaggt atatatattc tcaacaagct cagcaggcgt ttcacccatg 2895001 acgacttctc cgtttaccag agcgaaaagc gattccatac atgtcccgca gtagcttaag 2895061 cagccatatt caaggacatc aaggttggga tccttctcca aaatcgcccg ggcttcctga 2895121 gagccgtgag ccagattgct gacacaaaat tcaatcattg gattcatgcg gtttcacctc 2895181 acatatgtcc attatcgcga atttttcact attcgtcaaa gacaacggat gattcaaaat 2895241 ttattatcgt aacatattat ttctcaaata acgttttact aatttgtgtt ttcaggctaa 2895301 attgtaggtt attttgaaac tattattgtg attttagatc aaattcgata taattctaga 2895361 tgttatttta catagttcgt attttcttca atgtatctat catactcttc ggattaaagg 2895421 ggaattcaaa tgaaaaaatt ggtcttgatc ggcggaggtt acgggaacat gcgcgttctt 2895481 catcgcttat tgccaaacca gctgcctgat gatgtttcaa tcacgttaat tgacagaaat 2895541 ccttatcact gcttgaaaac agaatattat gcccttgccg caggcacaat ttctgaccat 2895601 catatcagag tgtcattccc agagcaccct cgcctggatg tccaatacgg tgatatcaca 2895661 tcaattgata ttgtacaaaa acaagtgctg ttccaagatc gtgaaccgat ttcttacgat 2895721 gacgccataa tcgggctcgg ctgtgaggat aaatatcaca acgtgccggg agcgcctgaa 2895781 ttcacctaca gtattcaaac catcgatcag tcccgcgaaa cctaccaaaa gctgaataat 2895841 ctgagcgcta atgccaccgt cgccattgtc ggagcgggct taagcggcgt tgagcttgca 2895901 agtgaattga gagaaagccg tgatgacctg aacattattt tgttcgaccg cggtaatctc 2895961 attttatcaa gctttcccga gcgtttaagc aaatatgtgc aaaaatggtt cgaagagcac 2896021 ggtgtccgca ttattaacag ggcaaatatc acaaaagtag aagaaggcgt tgtgtataac 2896081 cacgatgatc cgatttctgc agacgccatc gtgtggacag ccggcatcca gccaaacaaa 2896141 gtcgtcagag acttagatgt ggagaaggac gcacaagggc gtattgtatt aacgcctcat 2896201 cataatcttc caggtgatga acatctgtac gttgtcggcg attgcgccag tcttcctcat 2896261 gcaccgagcg cccagctggc agaggctcaa gcagagcaga ttgtccaaat cttgcaaaaa 2896321 cgctggaatg gagaagccct gcctgaatca atgccgcagt ttaagctgaa aggcgtcctc 2896381 ggttcactcg gaaaaaaagc cggcttcggg cttgttgctg accgtccgct gatcggccgt 2896441 gttccgcgta tgctgaaatc cggcttgctg tggatgtata aacaccataa cggttaatga 2896501 tagagaagaa ccgctgatca agtcagcggt tttctgtata cccatgcttc tccatttcct 2896561 cataaacgtc ttttaatttt ggattgcctt caccgacaat tttgtcttct acaagcacaa 2896621 gcggataaaa atactcgtca tttctgattt tttccgcaag ctctttcgca tgttcattgt 2896681 caggcggctc atgaatatcg atgtactgca tctcaaaagg ctgatttgga tattttcttt 2896741 tcagcgcagc ctcaagccac tcgtatgtat ccttggctgt cggcatattt acacagctcg 2896801 cacaaacgtt ttctgccccg tacacgctta gcatgactgg tttcatcact tgtagacgcc 2896861 cccttctcct atgtaagtcc tttcttttaa gtatacagag cctaagggcg tttttataga 2896921 aaaaaaccgt ttttgtgttg aagtctgaat gtgctataat agggaaagca actttgcaaa 2896981 ccaaacaata gatttttatt gttacactga atataatggt tttatgacga cgaaaggagc 2897041 gaatgtcatg actgaagttg aaatgaaaga acaggtgcag gaagtactgg acaaacttcg 2897101 tccgttttta cttcgtgacg gcggtgactg tgagcttgta gacgtagatg aaggtatcgt 2897161 taagcttcgt cttctaggcg catgcggcag ctgcccaagt tcaacaatta cgttgaaagc 2897221 cggaattgag cgcgctcttc ttgaagaagt gccgggtgtc gttgaagtag aacaagtctt 2897281 ttaataaagc agccaggctg atatttgatc agcctggctt ttttattaga gatgttgatc 2897341 aaaccatgag ctgatataat tcaggcgctt gatccgctgt cttgggtgtc cggtgcgtga 2897401 taaattgtgc gatgcattcg gaaaacggac aagcttggtt tccttgccca tttttttcag 2897461 agcgataaac agctgctccg cctgctcgat cgggcatcgg tcatcccgct cgccatgcag 2897521 tatcaaaagc ggtgtctcca cgtttgctgc gtattttaaa ggagaccggt cccagagctt 2897581 ttctgtgtcc tcaaacatgt catgctcaag ctgccagtct gtaaagaaat agccgatatc 2897641 actgacgccg tgaaagctga tccaatttga tatcgagcgc tgggtaacgg cagctttaaa 2897701 gcggttcgtc tgcccgacga tccagttggt cataaaacct ccgtagcttc cgcccgtgac 2897761 accgagccgc ttaggatcaa tatgcggatc tcgtttgata gcctcatcca cagcctgcat 2897821 cacatcgtca taatcctttc ccccataatc tcctctgacc gcattcacaa attcctgccc 2897881 gtagccgtgg cttcctctcg gattgatata aacgaccgcg tatcctttcg ccgccagcac 2897941 ctgaaactca tgaaaatatg tatgtccgta catcatatgc ggaccgccgt gtatgttaag 2898001 aataagtgga tatgttgtct caccttccat ttgtgcaggc ctcatcagcc agccgttcac 2898061 catcacgccg tcttctgtag catattgaat ctcttcaggt attgatatcg tatgctccct 2898121 gacaaacttg tcattcgcgc cagtcagctg tttctcttcc tgtccaagcg ggatactgta 2898181 aagctcactc ggtctgtccg gctttgtcac actggcaata aagtgctgtt catcaggtga 2898241 aagagaaaag ctattgatgt actctttttc cagacgaatc ggatacacaa ggccttcaat 2898301 cgaaatataa tagatgcccg tactgccttg atctgtgccg atgacataaa acccttggct 2898361 gtcctttgtc caaatcgggc gctgttcagc accaccgatc aatgaatctc caatcagcgc 2898421 atccgctaaa tgaacgtcca gcatctcagt aagacatgtg aggcggcctt gttcgatatc 2898481 atagagccac gcctttgaga gcgtagcatt cttatattcc ttttcatttc caagcaaagc 2898541 aagatacctt ccgtctggtg aaaatgagct tgatccgaat gagccgcgat gaggtgtaac 2898601 ctgcttaaga tctccagact ccagtgacat tatgtaaaca tcatgcggct tgctggcatc 2898661 atctgtttca gttaaattag ctgagaaaac aagccatttg ccgtcaggag aaaaagcagg 2898721 atcaccatga tcagctttgt gacttgtcag ctctttcatc tcacccgact ttacgctgac 2898781 aagcacaagc tgggcatacg cacctctcgt cagccctttg ccgtcccgtt tgtaggagag 2898841 gccttgcact tcaacaggtt catagctgtc ctgctctgtt ttttctcggt catcaatgct 2898901 ttccccctct cccaaactga cagtgaccag aatcgattca ccgtccgggg accatagcgg 2898961 ctttgacacg ccatatggga tatcagtcag ttttcttgct tctccgcctt cagtgctcat 2899021 gatataaagc tgtgccgcat cgccttctcg atcagaaata aaggcaagcg tgcgcccgtc 2899081 cggagaccat cttgggtcgg tgcttcgctt ttctccatgt gtccaaggaa cagatcctcc 2899141 cgttttcgtt tcatagatcc atatatttga tgtatacgaa tctttctctt gatttacttg 2899201 tgattttaca tatgcggcac gggtaccgtc tggggcgtat tgaggatcgg tcacagagac 2899261 aatcgctgtg atgtcgtctg cggttatcag ctttttcata ttcatctcct cctttttaca 2899321 tgtatttcgt ttttctaaat aaaaactcct ttatctccag caaaaaaaag cgccctccgc 2899381 tgacgctgag gaacgcttgg catgatctat acacttttta cttgatataa aggatttcgc 2899441 tctattatac ttccctcttt cggaacggtc aaagcgtcta cttcacaatg agggaaatga 2899501 agcgcgagct gttcttttag ctcttctccc tttccttttt cggtcatgac gagaatcgtt 2899561 gggcctgctc cgctgagagc cgttccatat gcgcccttca tctcggcgac gtgctctact 2899621 tttgacagct caggcacaag catcgcccgg tacggctgat ggaacatatc cttcttcatg 2899681 attttcccga caagcggcca atccttggac atgatcgcag caatgaggat attgctgaca 2899741 gcacttgctt ttacggcatc ggcatatgga aactccttcg gaagcacgtc tctcgcgtct 2899801 cttgtcagca cttcataaaa aggaatgaca acgactacgt caatgtcagc attcgggacg 2899861 cggatcattt gggtctcgtc atcctcatgc aggccgatca caagtccgcc gacgagagaa 2899921 gcgccagcat tgtccgggtg tccttcttct agactcgcta aatgcagctt gtccgcttca 2899981 gacagcttta agccgcataa ttcatcagcc agttcaatgg ccgctacaat cgctgcggcg 2900041 ctgctgccaa ggccgcgtgc aagcgggatg tcgctccaca ccttcacatg gacaggaggc 2900101 atttcttttc cgtacaaatc tgcggtccgt ttagccactt ggtagatcag gttatctgta 2900161 cccgccggaa ttccggcgac tgtttctgtt tcagcctcaa aagaccattt gtcgctttca 2900221 aagacggtca gcttcaaata tctgctgagc gccattccga ctgaatcaaa gccggggcct 2900281 aggttagctg tgcttccggg aacagtgaca gagaacagca tgtcggcttc gttcatacac 2900341 gggccgctcc ttttacatat tcaaggatgc tgtcttcatc agtcggcaat gtgacaggct 2900401 tgatttctga aatgtcgacc gctgtgttcg gatctttcag tccgtttcct gttaacacag 2900461 ctacgacctt gctgcctttc ggaatttctc cggatttcac ctgtttcagc actcctgcga 2900521 tagacgcgca agaacctggt tctgcaaaca cgccttctac acgggcgatc agctgatatg 2900581 cgtgaaggat ttcatcatca gtgacttcgt caattttccc attggattcc tcggctgcct 2900641 ttacagcttt gtcccagctt gccgggtttc cgatacgaat ggctgtcgct attgtttccg 2900701 gattttcaat cacttcattg cgcacgattg ccgccgcacc ctcagcttca aagccgcgca 2900761 ttttcggaag gcctgtgccg tttttctcat gatattcctt gaagcccttc cagtacgcag 2900821 tgatgtttcc agcatttccg accgggatcg ctaaaacatc aggcgcttcc cccagctgtt 2900881 cgcacacttc gaaggcagca gttttttggc cttcaatgcg gtaagggttg actgagttga 2900941 caagggcaat cggtgatttc tcacagatgg aacggacaat tttaagcgca tcgtcaaagt 2901001 ttccgtcaat tgcgataatc tcggctccgt acatgacagc ttgagcgagt tttccaaatg 2901061 caatttttcc gttcgggatg atgacaatgc atttcatgtt agcacgggct gcatatgctg 2901121 ccgcagcagc ggaagtgtta cctgttgacg cgcacataat cgtgtcattg ccttcttctt 2901181 ttgcctttgc cacagccata accattccgc gatctttaaa tgatcccgta ggattgacgc 2901241 cttccgtttt gacatgaagc tcaattccga gctgctcaga cagcttcggc aggtgaataa 2901301 gaggtgtgtt tccttcatgt aaagttagcg ccggtgtttg atctgttaca ggtaaaaatt 2901361 ctttatattg atggataagt cctttccaca ttagctccaa ccgttccctt ctacacgata 2901421 tgtgcttttg acttcttgaa cgacttccaa atcatttagg ttttgcagga tatcactgaa 2901481 atcagcttct gatgtatgat gtgtgacaat tacgatttca gctaactcat catggccttt 2901541 aattggcagc tgaaggattt tttcaaagct cacgccccgc tctgagaaca cagatgtaat 2901601 tttcgagaat gaaccaacct catcttttac atgaattctt aaaaactgct gtgcataaat 2901661 gtcagacggc gatttcatgt ttttctcata ttgcggtccg acaaagctgt tgccggttac 2901721 acctaggcgc atatttttca tgacagcgac gaggtcagaa acaacggatg tcgctgtcgg 2901781 catgcttccg gctcccggcc cgtagaacat cgtctcaccg acagcctcgc cgtatacata 2901841 aacagcgtta aactcattat gaacagcaga aagcggatga tggtcaggaa gcagtgtcgg 2901901 ctgtacgctg acctcgattt tgctgccgtc acgctgagca atcccgatca gcttcattgt 2901961 atagccgagg cgtttgctga agctgatgtc ctcgtctgta atttgggaga tcccctttac 2902021 tttgacgtct tccagatcca cgttcatcga gaagccgagg cgcgccaata tcgccatttt 2902081 ccgtgcggcg tcaagccctt ccacgtcaga agtcggatca gcttcggcaa aaccgagatc 2902141 ctgcgcttcc ttgagcactt cctcgtatgg gcttttctct ttgatcattt tggttaagat 2902201 aaagtttgtt gtgccgttca caattcccat catttttgta attcgatctg atgagaggcc 2902261 ttcctctaac gtgcgcagaa tcggaatccc gccggcaaca ctggcttcaa agtagatatc 2902321 gcatccattt tccttcgctt cggcaagcag ctcggagccg tacacagcca ttaagtcctt 2902381 gtttgctgtg acaacatgct ttttcgatct cagcgcgtcg accaaatatt gttttgtctg 2902441 ttcaacgccg ccgatcacct cgatgacgac atcaacatct ggatcatcaa tgacatcata 2902501 cacttctgtc gtgagcactt ccttcggcaa atctacttct ctctttttct ctaaatcttt 2902561 tacaagcact ttttttatcg taaccggaca gccgacctga tgcataagct tatcctgatg 2902621 gtcttgaata attttaacga caccgcttcc gacggtacct aaacctaaaa gccctacacg 2902681 aatcgctttc aaaaaaactc cacctttctt ttgattgtcc tcttggaaaa gacaattgtt 2902741 aactcaacac agacatataa gttacaaaca ttatataagc ccgctcctgt tttgacaaga 2902801 catcattagg ctgaattttg cgaatgtaaa cgcttaacgc attgatatga caagattctt 2902861 tattttctaa ttatttttgt cagattttct cctcaccttg agctgccttt gccgagccag 2902921 ctgacgcgtg gaacaaacag cttctgcgcc cgcatattca tgaattcctg cgctgtattg 2902981 agaaattgtt cataacgccc acagtcatta agaatgaagt caagctgttc ttcaaaataa 2903041 tgcttttctg attctgatga catgtaatag ctttctacga tttcaaaata atgaagcggg 2903101 aaaagcagac ggctgtataa aaggcgtttc gaaaatgaag acagcggtgt gacttgctcg 2903161 tattcctgta aaaagagaaa gccctgctga ttaaaatctt gtctgtgatg caaaaacgta 2903221 tgcctcatat attcagccaa atcacgggaa gcgtggtcaa acacccaatc cgccggaatc 2903281 ctgatcaatg attccggtga ccatgtatgc ctttccatcc gctgatggca tatcgttcct 2903341 gaatcagcgg cttggggctt gtcatccagc tcagtgtcca ctaaatattg tatcgcgttt 2903401 tctgacagtc ctaaataata tggaaatgat tcgatcattt ttttatcgaa tggctcatgc 2903461 ggaggggtct gaacctttct ctgccaaaat gcttccagct gatcaattcg ttttccccac 2903521 agatccttcc actggccgat tcttccggcc gccttcacct catatggata tcctcggcct 2903581 tttcggtgaa attccgcaag ctccgctcca atggagaacg ccctgtttga ataagggggg 2903641 gccgccttca gcagagcgta cgtttttccc tcatgttcaa atgtcagttc accttctttt 2903701 gtaaagataa aaaccgaaac gtatgggtca ctttgttctt gtaaatactg actcatgtaa 2903761 taaagctccg ccagctctgt ttctgagaat tgggaaacgg ggacaatcag aaagtatgaa 2903821 ttaggcgtct gaaagcattg atatgtgtgc tggtacatgg aaagctgcct gatgtgaatg 2903881 ccgtattttt cttttattgt acctttcacc atgatcacct gcctgttgaa ttagggctca 2903941 tcacatcgta gtcatacaca gccggaatta tgaatacata ttttaatccg aagaaggcgc 2904001 aagaaaaagt cgtaaacttc tcaagcattt tgtataaact agtaaaaaag attgggtgaa 2904061 gctgatgtca gaaaacgaac aattcagtca gatggaagct aaagcaagag cacggatgaa 2904121 ggagcgcggc gttgaggtat cagacattgc cgagcttgtc ttttttctgc agaaaaaata 2904181 tcatccggat ttaaccattg atgaatgcac gctgaacgtc aatcgtgttc tcgcaaaacg 2904241 cgaggtgcaa aacgcgattt taacgggcat tgaattggat gttcttgctg agcagaaaaa 2904301 attgtctgaa ccgctgcaaa cgatgctgga aatagatgaa agcctatatg gagtagatga 2904361 agttctggca ttttccattg tgaacattta cggatcgatc gggtttacga actacggtta 2904421 catcgacaaa gaaaaacccg gaatccttaa acgattgaat gataaatcaa ccggtgaatg 2904481 ccataccttt ttagatgaca tcgtcggagc gatttccgcc gcggcttcaa gcagacttgc 2904541 tcaccgcgcg cggcatacag aataagggca cccttttagg gcgccctttt ttcaaatgta 2904601 tggaatccat tcagtcagag agtcaatggc gtgagtcggt ttttccatat cgtctgtcat 2904661 atgttctctt ttcgttacgc ctgtgtgaac gagcagcgta tccatacccg cgttaatgcc 2904721 ggccataata tcagtggcgt agttgtcgcc gaccatgagt gtttcagaca catctgtgcc 2904781 gagaacgcgc atcgcctgct ccataataat tgattccggc ttgccgataa atacaggctg 2904841 tacacctgta gatacggtta acaccgatgt cagtgagccg tttcccggca ggagccctct 2904901 ttcagtcgga atcgcaatat ctccgttagt ggaaataaag cgggcgccat ttctgattgc 2904961 caggcagcca acagcaaatt tttcgtatgt aatggaacgg tcgatgccaa caacgacaaa 2905021 atccgcgttt tctccgccaa atgtcaggcc gttttcttca atcgcctggc ggattccttc 2905081 ctccccaatc acatacacag acgcgtcttt tttctgctgt gcaatgtgct gggcagttgc 2905141 catgctggtc gtgaagacct gctcttctgt tgccggaata tcaaaagaca cgagcttgtc 2905201 cgctacctgc ttcggtgtgc gcgaagagtt gtttgtcacg aaaagataag gaacgccgcg 2905261 atctttcagc gttctgacaa attcacacgc ctcctcgatt ttttccgtgc cattgtacat 2905321 cgttccgtct aaatcaatta aatacccttt atatgttttc atatccaaca ctcctgtggc 2905381 tttccagttg ttatttaaac gcggaaacag gtcctagctc tgtttccaaa tagcttctga 2905441 tccgtttcgg gaagtcctga agagctgttt gatgcgcctt gatcagcctg taaagctcgc 2905501 cgctgtcagc gagcagatac tgttgaacca acgttttgcg gtaggcgatc aattttttga 2905561 gctcatcacc ctctttttcc gtgacaactt tctcatcaac aagtatatcc ataatgtcgt 2905621 catagctgcc cgggtcccgc ataataaagc cgtcaatcat gtcattgcct gtatccaaaa 2905681 tgcattcgat taacagatgg cctatacgct gaagtgccaa ttccccgatt tcagactgcc 2905741 agtctgtttg tgagtcaaat agcgccagct ggtgctcgaa gaaccctagt gttttttcga 2905801 ttttgcttct gtcaacaaaa tacatgacag catccccttt gtgtatattt attttctgat 2905861 ccgtttcaag acaaaatacg cacagccgaa attgcagtat tcgtaaatat attcatctaa 2905921 tgtgctgatt ttcgtttcga aggttgcctt ttgattctgg tcgtcaaaga agcccttgag 2905981 ccttaactga ccgtatcccc agtctcccac aatataatcg tatttattta atatatcgga 2906041 gtagcgggct ttaaaagcct cttcgttgaa gccgtctttg aaattgtgca ccaattcaaa 2906101 ttcggcattt tgaataagaa tcatgatctc acctcttttt tcactcattc ctatcataat 2906161 tcattgcccc gtccccatca attgctaaag aataaatcat gcgatttggc taccctacac 2906221 atgaggaggg attgataaat gaaacgaacc gctgtcagcc tctgcctgct gaccggacta 2906281 ttatccgggt gcggaggcgc aggattggat aatgcccaaa atgtccggaa tcagacgcag 2906341 aatcaaacca aacccattca tgtgtcggac cgcaacgagg cttttaacag gcataatgag 2906401 aacgaacaat ttggctatgt ccgctatcaa aaagaacaat ttgacggaga acagcagaaa 2906461 acgccggtga tgaaccggga agaaaccgct cacatgatat caagtttaac ggttcagctc 2906521 ccccatattc aagatgctgc gacattggtg actgaccgag aagcgcttgt cgtatacaaa 2906581 accgattcta aaaaccggga gctgaccgcc gatcaggtga aaaaaacagc ggcttctgtg 2906641 ataccgcgat actatcacgt gtatatttcc gataatccaa accatatgca atccgtcgaa 2906701 aattacagca atctcggctc tggttcaagg gatattagag agatcatgtc ggggacgatt 2906761 caagaaatga aaacctcccc gcaaggaagc cctgtctcag agaatgaaaa tgccaatgga 2906821 gaaacgcgtc aggacatgaa aatcgatagg aatgacaaaa acgccagatg atctggcgtt 2906881 ttggcattat gcttgtgctt gacgcttttt agatgcttcg tttacttgtt catccgcatg 2906941 gtaagaggaa cggacaagcg gaccggcttc acaatggctg aagccttttt gcatcgcgat 2907001 ttcttttaat tctgcaaatt catcaggatg gtagtatttt tggactttca agtgtttctt 2907061 cgtcggctgc agatattggc cgattgccat aatatccacg ttgttcgcca agaggtcgtc 2907121 cattacttca ataatctctt cttttgtttc gccgagtccg atcatgatac ttgattttgt 2907181 cggaatgtca ggctgcattt ccttcgcacg gcgcaaaaat tccaatgaac ggtcgtacgt 2907241 cgcacgcgcg cggactcttg gcgtcaggcg gcgaaccgtt tcgatattgt gattcaggat 2907301 gtctgggcgt gtatccatca aggtttttag gttatcgtag tttccgccca tatcagacgg 2907361 cagcacctca attgttgtga acgggctttt tctgcggatc gcacggacag tttccgcgaa 2907421 aatgcctgcc ccgccatctt tctgatcgtc acgcgcaaca gccgtaatga ccgcgtgttt 2907481 caaattcata agcgcgactg aatccgctac gcgttccggc tcttgcagat caagctcagt 2907541 tggaaggcct gttttgacag cacagaaacg gcatgctctt gtacaaacag aacctaaaat 2907601 cataaatgtc gctgtacgtc tgaccgccca gcattcatga atattcggac actttgcttc 2907661 ttcgcatacg gtatgcaggt tgttttcccg catgagtttt ttgagccctg tatagttttc 2907721 atttgtattt aatttaattt taagccattc gggctttctg aggtgttcgt ctttctttgc 2907781 caattcccat catctccaat atccaatata ctcaatttct gacacgaaac attctgaaaa 2907841 cgagaaaggt gcaggtttta gttctgcaac aaaaataatg tttttctaac taaagaaagt 2907901 cttttcttta gacactttaa cataggaaaa atttctcgac aagggaagat gattactgac 2907961 atttttaagc cgggttgccg caaactatgt gtattcaata tgaaaggaga ttattttgtg 2908021 aaagttttgt tatccgctct tcttctcctt ttgtttgcat ttgagccttc tgcgtctgga 2908081 aaaaaacttt cagatccagt gctgtcgaaa cggatggaat tatatcataa aatcgaagct 2908141 gtgacgcaga tcccttggta tgcgctcgcc gctgttgatc aatacgaaga aaacgtgcgg 2908201 agcaaccgga aagatctgcc tgaaaaggcg ggaatcatca gcatctatat acccgatgat 2908261 atctggagcg ggcctgaaaa cccgaatccg aaagacgatg cgccgttaag cattaaagtg 2908321 tttgacggaa tcggaatgga tggcgatgga gacgggaaag ccgaggtcag caacgatgaa 2908381 gatatcttgt atacgttcag ccaatactta ctgtcgtatg gcacagatga agacaacatc 2908441 cggatcgggc tttggaatta ttaccggcgt gatcagacag tggggattat atctgaattc 2908501 atgaagctgt ttaaagccta cggccatatt gatctgggcg agcatgcatt cccgcttccg 2908561 atcagaaccg attacagcta ccgaagcacg tggggagatg cccgcggctt cggtggaagg 2908621 cggattcatg aaggtacgga tatctttgcc cattacggcc ttcctgtcaa atccacatgt 2908681 tacggcgtag ttgaaatgaa gggctggaac cgcttcggag gatggagaat cggcatcagg 2908741 gacattaaca atacgtatca ttattttgcc catctcaatg ggtttgccaa agggattaaa 2908801 acaggacaaa tcgttgagcc tggccaagtg atcggatcag tcggcagctc cggatacggc 2908861 ccgccgggaa ccgccgggaa gttcccgccg catctgcact atggcatgta caaagataac 2908921 ggaagaaccg aatggtcatt tgatccatac ccgcatttga gggcgtggga gcgatatgaa 2908981 taccaaaaaa agaagtaaca aaaagccgcc tcttcaacag gcggcttatt tgctgctttt 2909041 ttcttttttt gaatcggcac cgttttcttt gctgctcgga agctggacag aaggcgtgac 2909101 acccgagccg ccgcttccat tataaaactg cggcacttcg ccctgcactg ctttaatcga 2909161 tacaggaaca ttatttgtga cgacagcggt tttgctggca aatggaatga tgaccttcac 2909221 tttaatttcg acaaagatgc tgatatcaat aagtgcgtta tttatgccat acggcttgat 2909281 tttggttttg acatctgtaa aagcgtcacc gattaaattg aaccggaccg ggattttcgg 2909341 cccgaggttt ccaagaaggc tgttgccggt tacctgtccc agcggaatgt tgatcataat 2909401 gttttcactg gcgccgctgt gtccggtatg ggtttccatc tctttcaaat gagcctgaag 2909461 ctgctttgtc acttttgttt tcacactgtt tacaacctgt gtattaaaat cgattgtcgt 2909521 taagtttccg ttttcatcag aattcatttg aaacatatct ttcatatttt cactgtcaga 2909581 catatagtcc tcaatcgaat cctggatcac ctctgtcgct atacgcttcg tttccatctc 2909641 gccgatgtcc attaaaacag gtttgatcga gccattgatc atccaaaggc tgaccgttgt 2909701 tgacaggata aaaaagacaa cggacaggag catcacgtaa cggaaaggca aaggtcctct 2909761 cttgcgaaaa gggccgcgat atcttggcaa gaaaatcccc ccttacatat cacaatgtat 2909821 gcttgtaaga ggggacatag taatagccgg ggccaattta ttttatttca tcatttttaa 2909881 aagcgcttct ctgccgctca tgccgacttt gatgccaaga tcttccgcag cgtacgtgac 2909941 ggattctaaa ggtgcgtcta acagctggtc aatggtgcgg acaccaactg cgcgtcccgc 2910001 cacgatgccg cgctccttta atttttcatt cagcagcgcc acatcaagcg cgccgcacat 2910061 aatgtatccg tgatcattgg cgacggccat aaaattcgtt ttgggaagct ttactgtcac 2910121 agctgtaaaa ggctgtcctt ctatcatgat cggtgtcagg tttaccacgt caaccactcc 2910181 cttcattcat cactttatga tgaagggcac agcttgttgt gggctgactg ccttattgtg 2910241 caagcttcca agcaagcaga tcccgcaaaa attccggcat aaaatattct ttttctgcag 2910301 cgtcgcgaat caacggaaac agtttgccga gcgtaaacat atcaagcacc gcaacggagt 2910361 attgtttatg tttttcaata tcttccccgt tcagtgtgat ccgagtgacg tgggtgatcc 2910421 cgtcatcgag ccgtttcgtt tctacctcaa cgccggcata caccattttc cccatcactt 2910481 ctccgcggaa gccgagtcct ttgatccgga gctgctccat ttgttcggaa gcggcatgga 2910541 caatggtttc cttcagttct tctcccgtca ggcggacagc caccgggttg atcggatgcg 2910601 gacagatgcg gtgcagatcc agctttgtca caggacctgc ttttagcgga ccgagaatga 2910661 cacctgaatt gaccatactg atgtccgtct cgcaccattc ctttaaggcg tatgccaaaa 2910721 gcaaaggcag ctctgattct tcaaaccact tcacctcagc atcttgtgca agctctgcaa 2910781 cggcatcgga cagtttctcc tcggcttcac gttctttttc attgagaaac gctttagttt 2910841 ctgcggattc tcctgtccat tccgccatgt tctgcacaga agccgttttg ctgttgatgc 2910901 ttcgctgtac gctgtccacc gtgatttcta cacagccgac ataatgcccg tatttctcgg 2910961 cgctggccag cagtacccca ttaaccactt gtccatcttc gagcaaatga tgggtatgtg 2911021 attcgaggat tacatcaatc tcaggcaccg cttcagccac tgcttgatca tcaagaatgc 2911081 ctaaatgtga cagcagaacg ataatatcag cctgcccttt cacttccaga atggtttcct 2911141 ttatgctttc aagggcatcc gtaactgtcc atcccagctt gtcatataca ggataatacg 2911201 gcacagttac acctaagaaa gcaatggaca taccgttttt caatgatttg atatggtaag 2911261 gcaccgccca ggacggacgg tttccatttt tatcaaacag gttagagacg atgacaggaa 2911321 attcagcatg atcatataag gcagcaagct cttcatgcgg aagcgtaatc ccttcgttat 2911381 tgccgatcgc cgctccatca atgtgaaggc ggtttaagag atcgacattc gcttttccga 2911441 atgtcgcctc tgtcacgaat tgaaaacgat caagatgatc gccaatatca aaaacgagcg 2911501 tctcttcgcc gtctgactga tgctcttttc ttttctgctc gatataatct acaattttcg 2911561 gccagttttc aaaatggctg tgcaaatcat ttgtatgata taagcggagc ttctccttca 2911621 taatatctct ccctaatcgt tcagctgaaa atgccttcat aaatgagctg gcagccgatc 2911681 aaaatcaata cgatccgcat gatcataacg atcgttttcg tctgcatttt tctgttgatg 2911741 gcggcgccaa gctttccgcc gaaccaagcg ccgggcacaa gcgcgagggc gtacagccaa 2911801 ttgacgtgcc cggaaatcat atgtgaaaca gaccctgtca tagaagacag gaaaataata 2911861 aacatggacg ttgccaccgc aaccttcggc ggaaacagaa ataacagcat catcgccgga 2911921 accatcagtg atccgccgcc tataccgaaa agtccgccta aaaaaccgac aacaaaggca 2911981 atggcaatac cgacagaggc ctgatatgag tacgtataag gctcaccggc atcatcctga 2912041 aatgtccgga taattccttt gtgcgctttg ttgattggcc gggctttcgc tttcagcatt 2912101 aaggataatg aaatcagaat cataaaaatg ccaaaccaaa cggaaaacga gtttgaattg 2912161 aacagctttg acacgtaagc cccgatcatg ctgccgggac ccgaaccgat aaagaaaatg 2912221 agtccgctct tataatcaac tgttttatat ttaatataag ccaaagttga agaaaggccc 2912281 gtaaaaataa tgaccaaaag cgaagttcca atcgcaacct gcggcgtcac atcctgaaac 2912341 agctgcgtca ctgtgcttaa aaacatcaga gatggcacaa tgacaattcc gccgccaagc 2912401 ccgatcagac ttcctaccgt acctgcgatt aatcccagta cgaccaaaat cacaaacgac 2912461 atcaatcaaa acctcttttc taaaataaat cgagctgtct cggagcaagt ccgctgtact 2912521 cgatatcaag cagttcaagc atctgcttgc cattatccgc agcgtcaccg ccggaattgt 2912581 tgttgaacag gacaaaaaca tccttacatt gctgctgcaa ttcattcagg tgctttttcc 2912641 aatcctccag ctcctgttgg ttgtagcggt ataagtacct gacctcccgc cagtttttcc 2912701 cgccatcagg cttcatccag ccctgcttgt tgcgtccgtg aaacctgacg agcgttttgt 2912761 tttcatcggt cgcgcgcaac acggtcggaa cgctgccttc tccgatttgc ggttcatcac 2912821 agacactgtg aatccagcct tccgctttca taaatgaaag cgtctgctca taaaatggcg 2912881 gcgagaacca ggaacggttt ctgaattcaa gcgcgcaagg aatatctccc atttggtgct 2912941 tacaccatct caaataggcg acattctcct tcttgcagtc aaaccacggc ggaaattgaa 2913001 acagcaccat ggcgagctta ttgctatgta aatatggcgt taaagacacc ttaaacgcat 2913061 caaacatctc ctcttttgag tcaaagggaa tttcgccgcg ctgatgccct gtcatgccct 2913121 gatatgcttt cacgataaat tggaaggttt cgggcgtttc cttcacccac ttttcattat 2913181 tgcgcgccgg ctgaatcgcg taaaagctcg cgtctaattc cacgatcgga aaatgggagg 2913241 aataggcctg caattttttc tggctggccg ttttcggcgg atagatgctg tcatgatccc 2913301 cccatcccgt cagtccgata taaatcacac tcattcacct ctcttccagt ttatcacacg 2913361 tgttttcagg tttcctcgga aatgctgttc atatggcggg aaaatgcctc acgcaaatgc 2913421 tgatattgtt cctcattcgt atctaaaaac gcctcttctc ttgaggaagg aatgtgctga 2913481 tattcaatag gcgcctgaaa ctgctcactc gtaaaatcgt acaccacacc attgatgctg 2913541 ttataaaaat gccagctctc atcgactctt gttttgaaaa tcgtgccgcc gaaatggtct 2913601 tgaatcacca atgccgtcac gccgcattgg ccgcatgacg ggcattcttc cgtccattta 2913661 gagctcgaat ggcgcgacca ggattgctta agtatgtatt tgacatgctc cattgcctcc 2913721 gcctccttta aaaaaagata ccacgttgat gagattttaa aaactagaac ggaggaaatc 2913781 aaaaaacccg gcggtaaaat ccgccgggct tacgaaggaa cgaccagagc tccgtcaatt 2913841 tcagtgactt tttccccatc attgtacacg caccggcctt tgctgtaagt ggccgaaatg 2913901 ctgcagggaa atgtatgtcc ttcgtaaatg ctttttttat gctttgcaaa catcgattct 2913961 cttgtaacag tgtacggctc catgctgacg agcacgaaat ctgcatcaca ccccgcctca 2914021 agccgccctt ttttctgaag gccgaatcgt tttgcagggg ccgccgctgt ccattctgcg 2914081 atggtttcaa atggaatctg atgctcaagc gccagttcca gcattcctaa taaagtgaac 2914141 tgcccgccgc tgattccgcc ccatgataaa aacatgttat cctcccgctt caaggatgga 2914201 cggcaagggg aatggtctga ggaaaccatg tcaatgtccc cggcaatgag cgtctcgatc 2914261 agcgtctctt ttgattgccg tgaccggagc ggaggcgcgc attttgcgac agagcccctt 2914321 tgccgtaaat cgtcatggct gaacaagaca taatgcggac atgtttcaac cgaaacatca 2914381 agaccttcct gtttcgcctc tctgatcagc cggaccgctt tcgccgtgct gatatggaca 2914441 aaatgaaccg gacagcctgt caccttcgca tactgaatcg tgcgatacac cgcttcaact 2914501 tctgcttcct ccgggcggga ggcggcgtac gcatccgcat ccacctttcc tttattggcc 2914561 aaaaccatct gcaagtagct tgtgatcgcg tcgctttccg cgtggagagc gaggattttt 2914621 cctgcagccg cgatttctgc catgcctttg agcaatgtcc gttcatcaac agagcggaac 2914681 tcatcagtgc ctgactttga taaaaacgct ttaaacccga tcgctcccgc ttcagccatc 2914741 ggacggatgt cctcgatatg gcctggcaca aggccgcccc atagcgcaaa atccacggca 2914801 gatttttgcc tgcctagctc agcttttgcg agaagatgct ctgccgtcac ggttgatgga 2914861 atacagttga gcggcatatc aaaataggta gtgcaaccgc ctgcggccat catttgagaa 2914921 cctgtttcaa acccctccca atcctccctg cccggttcat taaaatgaac atggcaatct 2914981 atcacaccag gaaacacgta tttcccgtct gcctggatga tttccgtccc gcttgcttca 2915041 atgtcagaac ctatctcggc aatgacaccg ttttgaacta caatatcagc ttctataacg 2915101 ccatctggcg taactgcctt cgcacctttt atcaccatat cgtaagccat attgatcccc 2915161 ccatgtcagg atgacgattt tccatgtcag tttatgtaac acaaccagtt ctattttcaa 2915221 cagtttactg ctactatgat cgtattacat cagcaaaacc gctagaattc ctattgaaaa 2915281 ttattcacct taaccaatgt ttttatagaa aaggagaatg cgctatgaat attcttgatg 2915341 tgatgaaaat accggctttt gaaaacgcca atttaatcgc tggaaaagca ggaggggaaa 2915401 gagaggttca gcatgtcaat atgatggacg ctccggatat cgtagacttt ttgcataaga 2915461 atgaattgct cgtcaccacc gcctatcacc tgaaggatca cccgcatcaa ttatctgaac 2915521 tgattcggca aatggcaaaa cgcggctgcg cgggcctcgg cattaaaaca aagcgctatc 2915581 tggaagatat cccgaaggaa atcatcgaac tggccgattc atatgcgttt ccgatcattg 2915641 agcttccgga acacatccga ctcggcgata ttgtgaatgc cacactcagc catattctcg 2915701 atatgcgttc taacgagctg cagcaagcca tttacgcgca caaaaaattc acaaaccaca 2915761 ttatgagcgg caaggggctg caatccctcc tcaaaaaggt gtcagacatc cttcagcttc 2915821 ccgtgctgct gcttgaccag catgccaaaa tgctgtctgc gtctcatcag atttcagttg 2915881 agaccgaaaa gctgaaaggc accctgaata ccgtatccgg gccatttttc acttgtttct 2915941 ctacaatctc agatcagaaa acatattctg tcctgcctat ttataatcac gaaaaaaact 2916001 gcggctacct gctgataccc gacatggtgc aggcaggcga caaaggattg atcctcacga 2916061 ttgaacaagc ggccaacgtc atttcctttg aactgctgaa ggaaaatgcg ctgaagcagt 2916121 tcagccggcg ggcccgcaat gagtttttca acaattttat tgagcggacc ttttcttcag 2916181 atgacgaaat caaaaaccgg gcgaaagaat tcaagctgcg ctgggatcaa aaatacatgt 2916241 gcatcgccgg caaactcgat cgcaatgacg aatcaatcag ctttacagaa aatcagctcg 2916301 cttccgacag cgtattcgaa tttcttgaag gtgaattatc agccttcccg tttccacctc 2916361 acttctttat gaaaggaaat gtcggcatta ttctaatcga ggcgacagac agctggagtg 2916421 aaatgcacgc ctcggtgatc agctttttag aacagtttca aacacaggtc agcgctcaat 2916481 ttaaacgaac cgtgtccttt ggcatcagca atatctgcca aaagctcatt gatgttcccg 2916541 acgctttcac agaagcttct gatgctctgc aatcggggca tttgtcaaga agcaccgcat 2916601 ttatccaggt gtatcacgcc aaagatgtgc ctgagcttct gcgcttgctc ccagttgagg 2916661 atttgaagaa attttacaac tccacgcttc agagcctcgc tgaaaaacag caggaggatc 2916721 aaagcctgct tcatacgctt tccgtctatt tagagacaca ctgccaaatt tcagagacgg 2916781 caaagcgtct gtacgttcat cgcaatacgg tcatataccg ccttgaaaaa tgcgaagagc 2916841 ttctggggaa aagcttaaaa gatcctgaaa caacgatgcg tttgcggctt gcattacgta 2916901 tgcagcggct gatcagctaa agtttgttac attttcttac aaaacgaatc gtttttcgtc 2916961 actttcagca atcacacctg tctttttcag ctactgtatc caatgacacc cctcgaccgg 2917021 aacgatatta tgttactaaa gttcacatac agggagggac tatagtgaaa aaaagatcgt 2917081 ttaaggtgtt tacacttagc ctgcagcatg tgctcgccat gtatgcaggt gcgattttgg 2917141 tgcccctgct tgtcggcagg gcgctgaatg taacaactga acagctgtcc tacctattgg 2917201 cgattgacct gttaacatgc ggcgtcgcta cgcttttgca aaccttgcgc ggaacataca 2917261 tcggcatcgg gcttcccgtc atgcttggca gttcatttgt ggccgtcacc ccaatgattg 2917321 caatcggcag caattacggc attcacgcga tttatggttc catcattgcg gccggtgtgt 2917381 tcatcttttt gtttgcgcgt tttttcggca agctgactgt gttatttcct cctgtcgtaa 2917441 caggtaccgt tgtgaccttg atcggccttt cacttgttcc gacaggtgtg aaaaatatgg 2917501 ctggcggcga aaaaataaac ggcagcgcca accccgaata cggttcgctc gaaaaccttc 2917561 ttctctctgt cggtgtcctt gttctgatct tagtcctcaa ccgctttctc aaaggatttg 2917621 cccgaacact gtccgttctg atcggcatcg ccgccggaac agcggcagca gcgatcatgg 2917681 gcaaagtcag cttttcttct gttacagaag caccgttctt ccaaatcccg aagccttttt 2917741 acttcggagc ccctgcgttt gaaatcggtc cgatcttaac gatgctgatc gtcggaatcg 2917801 tcattattgt ggaatcaacc ggcgtttttt acgcaatcgg aaagatatgc ggcagacctt 2917861 taactgacaa agatctcgtc aaaggctatc gagcggaagg aatcgccatt ctcatcggcg 2917921 ggctgttcaa tgcctttcct tataatacct ttgcgcaaaa cgccggctta ttgcagctga 2917981 ccaaagtgaa aacaagaaac atcgtcgtta ccgcaggctg tatccttgtc tgtctcggac 2918041 tgattccgaa gattgccgcc cttgcatctg ccgttcctgc tgctgtactt ggcggcgcga 2918101 ccgtcgtcat gttcggcatg gtgattgcct ccggcgtcaa aatgctcagc acagcggatc 2918161 tcaaaaatca ataccacctc ctgaccatcg catgctcaat cgcactcggc atcggcgcca 2918221 gcacggcccc cgggattttt gctgaattcc ccgctccgat ccggattctg gtcagtgacg 2918281 gcaccatcac cggaagccta accgccatct ttttgaatct atttttcagc ttgcgcgaca 2918341 aaaaagaatt aacagcacag caaacagaac ttccggtatt agaacataca ctcgcattag 2918401 aaaaagaggt gtaaaaaaga tgaaggaaca gcacaatgcc ttacagctaa tgatgctggg 2918461 gcttcagcac atgcttgcca tgtatgcggg agccattctc gttccgttga tcgtcggagc 2918521 agcgatcggg ctgaatgcgg ggcagctgac gtatttaatc gcgattgatt tgtttatgtg 2918581 cggggcggca actcttttgc agctctggag aaaccgatat ttcggcatcg gccttcccgt 2918641 tgtgctcgga tgcacgttta ccgcagtcgg cccgatgatt tccatcggaa gcacttacgg 2918701 tgtcccagcg atatatggtg ccattatcgc cgcaggactg attgtcgtct tagccgcggg 2918761 cttcttcggg aagcttgtcc gtttttttcc gcctgtcgta accggatcag tcgtcatgat 2918821 catcggcatc agcctgattc caacggcaat gaataacctg gccggaggtg aaggaagcaa 2918881 agaattcggc tcactcgaca acgtgctcct cgggtttggc gtcacagctt ttatcttatt 2918941 gctgttttat ttctttaaag gctttatccg ctccatagcg attttactcg gtcttatcgc 2919001 aggaacagcg gctgcatatt tcatgggaaa ggtcgatttt tctgaggttt tggaggcgtc 2919061 ttggcttcat gttccgtctc tgttttattt cggaccgcca acctttgagc tgccggctgt 2919121 tgtcacgatg cttctcgttg caattgtcag cctcgttgaa tcgacaggcg tttattttgc 2919181 cctcgctgat atcacaaacc gcaggctgtc ggagaaggat ctggaaaaag gctaccgggc 2919241 agaaggcctt gcgattttgc tgggcggctt atttaacgcg tttccctata cagctttctc 2919301 gcagaatgtc ggcatcgttc agctctcaaa gatgaaaagt gtcaacgtca tcgccatcac 2919361 aggaatcata ctggtcgcga tcgggctggt tccaaaagca gcggccctga caacagtgat 2919421 ccccacccca gttctcggcg gcgcaatgat cgtcatgttc ggcatggtca tttcttacgg 2919481 gatcaaaatg ctatccagcg ttgaccttga ttcgcaaggc aacctgctga ttatcgcctc 2919541 ttccgtcagc ttggggcttg gcgctacaac agttcccgcg ttgttttcat ctctttcggg 2919601 cgcggcctct gtcttggcag gaagcggaat tgtgatcggc agtttgacgg ccattgcact 2919661 gcacgctttt tttcaaacca aacagccgaa tagcgcagac ataaaaacgt aaaggaagat 2919721 gccaatgttc acaatggatg acctgaacca aatggacaca caaacactga cagacacact 2919781 tggctctatt tttgaacact cttcatggat tgcggagaga tccgcagcac tacggccgtt 2919841 ttcgtccctt tctgatcttc accgcaaaat gactggcatt gtaaaagctg cggatcgcga 2919901 gacacagctt gatttaatca aaaagcatcc ccggctcgga acaaagaaaa caatgagcga 2919961 tgactcggta cgagagcagc agaacgcagg gctcggcaaa ttagaacagc aggaatacga 2920021 ggagtttctc atgctgaatg aacactatta tgatcgcttc ggctttcctt ttattttagc 2920081 ggtgaaggga aagacgaaac aggacattca ccaagccctg ctggcaaggc ttgagagcga 2920141 acgagaaacg gagttccagc aggcccttat agaaatttac cgaatcgccc gctttcgtct 2920201 ggctgacatc atcactgaaa aaggagagac gcaaatgaaa agaaccatgt cttatggcaa 2920261 aggaaatgta tttgcatacc gaacgtattt aaaaccgctc actggagtga agcaaatccc 2920321 ggaatcatct tttgccggaa gagataatac cgttgtcggc gttgatgtga catgcgaaat 2920381 tggcggagaa gccttcctgc catcatttac agacggagac aacactctcg tcgtggcaac 2920441 ggattcaatg aaaaacttta tccagcgcca tctcgcatcc tatgaaggaa cgacaaccga 2920501 ggggttccta cactatgtag ctcaccgatt tttagatacc tattctcata tggacacgat 2920561 cactctgact ggcgaagaca ttccgtttga agcaatgcct gcatacgagg agaaagagct 2920621 cagcacaagc cgcctcgtct tcagaagatc gcgtaatgaa cgaagccgct ctgtgctgaa 2920681 agcagaacga agcgggaata ccataacgat tacagagcaa tacagcgaaa tcatggatct 2920741 tcagctcgtc aaggtgagcg gcaactcctt cgtcggcttc atccgggacg aatatacgac 2920801 tctcccggaa gacggcaacc gcccgctgtt tgtctattta aacatcagct ggcaatatga 2920861 aaatacaaat gactcatacg cttctgatcc agcacgctac gttgcggctg aacaagtccg 2920921 cgacttagcg agcaccgttt ttcacgagct cgaaacccct tcaatccaaa acctaatcta 2920981 tcatatcggc tgcagaatat tagcgaggtt cccgcagctc actgatgtca gcttccaatc 2921041 tcaaaatcac acgtgggata cggttgtcga agaaatcccg ggctcaaaag gaaaagtcta 2921101 caccgaaccg cgcccgccat acggtttcca acattttacc gtgacaagag aagacgccga 2921161 gaaagaaaaa cagaaagccg ctgaaaaatg tcggagcctg aaagcctgat gggaaaactg 2921221 acaacccata ttttagattt aacctgcggc aaaccagcgg cgaacgtaaa aattggattg 2921281 aagcggctgg gcgaaagtat tatgaaagag gtatacacta acaatgacgg cagggtcgat 2921341 gtccctctgc tggctggtga agagctgatg tcaggagagt atgtgatgga atttcatgca 2921401 ggagactatt ttgcgagtaa aaacatgaac gcagccgatc agccgttttt aaccatcgtc 2921461 accgtccgtt ttcagctagc agatccagat gcacattatc atatcccgct cttgctgtcg 2921521 ccgtttggtt atcaggtgta tagggggagt taagaaggaa gcccgcctca ccggcgggct 2921581 tctttttgca cttcaattaa cttttgatcc taggacagta cttgaagtga tccccacact 2921641 tagtgaaaca acagctagaa taaacattca cctatatttt tcaggataat tgcctacgag 2921701 aaaaataccc tgtagtcctt tcatttataa atcgaggttt caaactaata agtcagctct 2921761 tagcagccga gctcccttct ccaatcctat aaacagaccg cgttttttct cgaaaaaata 2921821 ctctgaagac aattgctgcg tttttaatag ttttgataac gcgttctctc ttacaccttt 2921881 agacaaaata ttcatttttt cttttttaga cttaaatcta tgtcgaaaat aatcgttggc 2921941 atatcttatc ctatctccac taaaggaggt gacattatgg gattctacaa ttctggtgga 2922001 tacagtggaa actctggtta ctcaaacggt ttcgggagct ccttcgcttt gatcgtggtg 2922061 ctattcattt tgttgatcat tgttggagca gctatcttta attattaagt ttaactttcc 2922121 ttgcctccgc cgtatccaac acctccctgt ccgacagacg ccataagaag tttttatggc 2922181 gtctttgcta tgtgttcact aatctttttg taatccagaa gctgtcaagt tctacgagat 2922241 ttatcgtgtg ttttcccaca acgcttctgc gtcttgatcg cgctgtctga ctgaggctaa 2922301 aaaagtccgg cttttaaaag ccggactccc gtctaccccc gttcaactct cttctaatcc 2922361 tgcaagctga ccgcataatc ccgccatacc cggtacaccg gcacaaattc cccgccagcc 2922421 cttcttctat atctttgtca gaaggttgag gggtttcccg aaacaatgct ttaagcgcaa 2922481 tgatcattcc cggcgtacag tagccgcatt ggaagccgcc ttcttccagg aaagcggttt 2922541 gacacatatc cagctcttct ttttgaagcc cctcgatggt tgtgatggaa tggccgtctg 2922601 cttgataggc catcgtcatg cacgcattgg ccagttttcc gtcgattaaa atagagcagg 2922661 ctccgcagcg gccgattccg caggacacct ttgtcccggt cagctgaaat tcctttctaa 2922721 gcaggtcact cagatgtgtc gtaggaacgg cagcaacctc ccacgcctga ccattcacgg 2922781 tcatccggaa ctgttccttt tttacaggaa atggcccggc ctcttttatg tccattgctt 2922841 cagccccttt ctgtcgatcg cttcaagcaa ctcttctctt gaaattggca gcttgtttat 2922901 ccagcatccg accgcatcat gtactgcctt tacaatcgcc ggagtgatgg cgattgttcc 2922961 gatttcacca acaccgcgcg gtccatatac gtctcccttc attaagtctt ctattgcaat 2923021 cagcttcatg tcaggaacat ctttgattcc gggaatcaaa tagtgatcga gattttccgc 2923081 agcataacgg ccatccgtca ttttcgcttc ctccatcagt gtgtagccga gtgccatggc 2923141 agcgccgcct tcaatttgac ctcgatatcc ctgcggactg acaaccggac ctgccgcaat 2923201 agcgtgctca caatctatca atttgacatc gcctgttaac agatctacct ccacctcaac 2923261 ggcagccgct ccaaatgagt agaggaaatg gccgcccacc acaggatcag gcgttgttgg 2923321 aaagtcaaag gccgtttcct ctgccaaagg gcctttttca gccagctcct tatacgtcac 2923381 cacgagcgcc tttgtgtttt tgtcacgcaa gcctgcagcg ccgggaataa gattttccgc 2923441 tgaacagccg ctccattctg ccgcccgttt tttcaactga gctagaaacg gcttcttcaa 2923501 acgctggatc gcgtgccaca ccatgcttgt gccgcgggat gctgtggagg agcctgactt 2923561 cggcactttt gcggtatccc caataacaat ggaaatatcc tctgcggcac aacccagctc 2923621 ctccatgaca atctgttcaa tcgctgctag aatcccctgt ccgcattctt caaatccaaa 2923681 cgaagcagtg attttgcctt cactcgaaag agacaaacgg cctcctgccg catccattcg 2923741 gccaaacccc agcccgccgc cgtgcattgt aattgccgct cccgtgcctc tttgcagata 2923801 cccgcagttc cggcttgttt ttttaagaat gggagattta gatatggcat tcaacacctg 2923861 tgccgctccg tcagttggtg caattcgatg ctcaagcggc cccaagtcat gcggttttct 2923921 gatatttttt cttctcagct cgagcgggtc gatgccaagc atgccgctga gacgatcgag 2923981 atgggtttcg agtgcaaatg tgatttggtt gccgccaaag ccccgaaatt cccccgccac 2924041 cccgttgttc gtaaatactg atattccttc agtccggata ttcggaatac ggtacggccc 2924101 cgcggcatgc tcgacagaaa aatcaagaac agccggtccg agcgtagcgt aagcgcctgt 2924161 gtccgccaca attttcacgt cgtgcgccaa tagatttccc gaatgatctg cacccgtttt 2924221 tatcgtaatc ttcatcggat ggcgcttaat gccagaacgt acagattcct ttcgtgtctg 2924281 atgaattttg acagggcgtc cgcttttcag ggccaaaagc gcagcatacg gctgaatatt 2924341 cagctcatcc ttccctccga acgagccgcc catcggactt gacacaattc tgatcttctc 2924401 ttcaggaata tcaaaaatac gggcaagctg gaaacggtct ttatagccgt gctgggttcc 2924461 tgcatacatc gtaaaacccc cgtcgtcttc cggaacggct acacctccct ccgtttccat 2924521 atacgtatgc atctgccgcg gcagctcata ggtttcttca aagactgtgt cagatgcttg 2924581 aaacccttct tccacatcac cgtttgaaaa aaatgcgcgg tgcaggatat tcccgtcctc 2924641 atgcagtctt tgcgcattcg gccgaagcgc tttttctggt gaatccatga cttccagctc 2924701 tttatactca acttgaatca gctccagcgc cgcttccgcg atttcttccg tttccgcagc 2924761 aactgcggcg atcgcatccc cgacataccg caccctgtcc tcacataaaa ccggctgatc 2924821 agggatgaca atgccaaatc ggtttaagcc gggaacgtct ttatgtgtga cgacggcctg 2924881 cacgccttcc attttctcag cttttatggt gcaaaccgac acaatctctg catgaggata 2924941 agcacttctc agcaccttgc catacagcat tcctggaaag ctgagatcgg tcatatattt 2925001 caattcccct gtgaccttac cccttccatc cggcctgact cttgacggtt tgttgatgat 2925061 catttattcc cctccctcag ccatcagctc tgccatgatg acgttggcag cggctttttt 2925121 tctgtatgcc gctgacataa aaacatctga ggaaaacggc agctcatgga taagtgtttt 2925181 gtacagctca tgcgggtccc accctggtgc catccatttc gcttcgctgt ccaataatct 2925241 cctaggagtg atatcggcat ggccagcggc gaggcgaatg ctgccgtctt tcaaaaaacg 2925301 tccagctgca acagcagccg ctccggtaaa agcctggcgc cttccaagct tgtgataaaa 2925361 tacacgctct ccctccgccc gcgggatgat gacacgcgtg acgatagccg ttctaaagtc 2925421 ttcctcactg agccaagcgc caagcggcag cctgattagc tccttttgat atacgataag 2925481 ctcagcacca agcacaagca gaagcggaat gaaatcaccg attttactcg ctatgttgcc 2925541 gccaatcgtg gcacggctgc gaatccccgg tgcagcgaca gcggaagcag cgtcactgaa 2925601 acagctaagc gctctcttaa tcaaagggtt ctttctgcat tcattcagtg atgtgagccc 2925661 cccgatcgac acgtgggtgt cactggtgct gatccctcgc atttcgtcaa tcccttcaag 2925721 gctgacaagg tgctgtttcg gtagagttcc tttgtcccac tgaagctgaa ggagcgtgct 2925781 tcccgatgcg gcacacacat ccggagcaag cttctctaaa agcgaatagg cctcatcaag 2925841 cgctgccggt ctccataatt gaatattcat ccttgctttt gtcacttggc cgttcaagac 2925901 atcgccctcc ttaccatgtc atattcctcg ggtgtatcaa tatcgtccaa ctcaccgcta 2925961 tcctttgcct ccaaaaccgc tcctgctcca agctgtccgc ttttcaggag cctgcgagcc 2926021 ccttcatctc cctttaatcc ctttacataa ggaaaacatg tcgacgagaa gtagattggc 2926081 ggggtgaacg cccctaaaaa cgatgacacg gcaaatgact caggagccag agccacaagg 2926141 gcattgagat gatcgacgga aagctgaggc tggtcggcta acaaaatgac aatgccgtcc 2926201 gcccccatgc tttctgcttt tctcaccccg ctgctgactg aatgcccctg acccttttct 2926261 gcgtcttggc aaacgtgcag gctccagcgt ttttgaaaag gcggagcgtg atacggcgct 2926321 cctatccact caagggaggc atgttctgtc cgctcgacga ccagcacgtg atcaaggcgg 2926381 gacgacagag cagttttcaa ggaaagtgag cctatgtttt ctccttttag cggcaaagcc 2926441 agcttgtttt gtcccattct tctgcttttg ccggcagcga gaaacacgcc gatcagatag 2926501 gggcttctca tacaaccgcc acccgttttc ttgtttgaat gatttctgca actacactta 2926561 ccgcaatttc ctcgggacct tccgcaccga ttttcagccc gaccggactg taaaagtgag 2926621 acggaggatg ttttccgctc agcagccgtt tcgtgcggtt tgccgaaccc aacagtccaa 2926681 tataatggag gttttgagaa aataagaagt tgatgatcgt ttgatcgtgc tgataatgat 2926741 gggttgccac aacagctgca tcatgcggaa aaaattgaaa ttcgctaagc atttgttccg 2926801 gaaaagcggt gatcagctga tccgcttttg gaaaaagaga ggatgtacaa taagcgggcc 2926861 gccaatccgt cacgataaca gaaaaccctg tgtcagccgc caaattggcc agcggtacat 2926921 tatccggtcc cgccccaaac agaatgagac gcggcttcgg ttcaattcgc tgaataaaca 2926981 tgttagtggt ttgatcgaaa tgcggtaaat gaagcgttga aacagtacgt tgaatatctt 2927041 gcagaggcgc gtccggccag ttcccaaaat gtccgttctc cgtcagaaat aaataatggg 2927101 aggattcaat ctttataacg gaagtgacag ctttgcctga atgaaggcag tccctcactt 2927161 tctcatagtg ccgccttttt tcctgagtga ttcgctctgc atgaacatga ataatgccat 2927221 tgcacccggc tcccatgccc caagaaagat cgtcctccga ccgcatgtcg tagggaatca 2927281 gcgttgatgt gagctgatcg cccagcgcac tgattctttg gaatacatct tcttccacac 2927341 acccgccgct cagcaagcca atccgtctgc cttttttctt aaagagcata gaggcgcctg 2927401 cttttcgata cgcggagcct tcaacttgaa caattgtcgc cagtacagcc tcctcctggt 2927461 cttccaggag cgcatctaac atcgtgtgaa aattccccaa tgccgcatcc tcctctcgaa 2927521 aattgccgtg agaaacaact agttcagcgt gattttatag gtaacttgta taaagaatag 2927581 acgatggaag aaaaaatgac tcatgatttg tcagaaaatg aaacacatag aaagaggatt 2927641 tgtaaaaaga gtcaaacgaa gaaaatcaga ttggagaaaa cacgaaatca tatcgttaaa 2927701 aagcttgcgg agttccgcaa gcttttcttt acaccgctgc ctggcggcca gcgttttcat 2927761 acacatccag cgctgcttgg agcgcttttc ctgcttcgat tcctgcgtta tgtctgagaa 2927821 gcacagcctc taacccggca agcacgaata gcacgttttc ttttctgcag ctgtacccca 2927881 tcgtgccgat cctccagatc ttccctgcaa gcgggccgaa tgagctggcg atttcaatgc 2927941 cgaattgtgc cagcagcatg tcacggacag actcgccgtc aatgccgccg ggaatttcga 2928001 cacaggtgac aacaggcatt ttgcagctgt catctccaaa caatcttagc cccattgcct 2928061 ttatccctgc tgctaatgcg gcttcatggt gccgatgccg ctcgaaacgc gtctcaagac 2928121 cttcttcaag caccagtctg actccctcac gtaaggcgta cagcatcgtc gtcgcttctg 2928181 tatgatgatt gagccgtctt tcgctccaat aatcctcaag ctggctcaaa tcaaagtagt 2928241 tgcttgtaat tggccgattt cccgaaagtg ctgccctgtc agcttgtgtc gcaatcccgc 2928301 gttccacctt tttgcgagct gcaatcacgt ccgccacccg ctcattatat gtaatcggcg 2928361 ccattcctga aggcacagac aaacattttt gcgttccgcc gatggcagcg tcaatcttcc 2928421 attcatcgac tttaacctcg cagcccccaa tcgttgcgac tgcatcgacg ataaacaatg 2928481 catcctcggt gcggcaggct tcgccgatgg ctttcagcgg gtgaatccgt cctgtcgatg 2928541 tttctccatg caccatggcc acaattttcg gcttcacttt ttttatctcc cgtatgatgt 2928601 cctccgggtc aaaaaccgtt ccccattcgc actccagcat atgaacattt gccccatatc 2928661 gctcggcgat ttcagtcagc aaataaccga aacggccgta aatgggaatg agcacatcat 2928721 cttccggctc tatcacacta gccagcactg cttcaattcc cgcccgtgaa gtgccgtcaa 2928781 tcgggtatgc ccagcggttt tttgtttgga acagctcccg aagcatctcc atcgtttcat 2928841 tcataatacc tgtaaacgcc ggatcaaatt ggccgacaac cggggtgctc attactctta 2928901 atacacgcgg atcaacctca acaggccccg gtgtcataat cgttcttaac ggggtgcata 2928961 attctcttct gcctgacaca gccattcctc ctttatcagt aagccagttt gtataataaa 2929021 tcagtcagtg cgcggacgcc gatctcaagc tgtctggctg acgtatattc cttcggtgag 2929081 tggctgacgc cgcctcggct cggcacaaac agcatacaag caggatagcg ccttccgatc 2929141 atttgcgcgt catgccctgc tccgctcacc atttcctcac agctgaagcc gttttctaat 2929201 gctgtttcaa aagccgcagc cttcagcctt tcgtccatcg gcacaggctc tatccgcata 2929261 tattcatcaa tcacagcgcg aattcctttt tgtaggcaaa tgccgttgat caaagcaacc 2929321 atgtcttgat gaaactgttc cagcacatgc tgatgctgat ggcgaatatc gattgaaaac 2929381 tggacgcggc ccggtatgac attggctaca ttgggctctg ccgttatttt tccgcatgtc 2929441 agacggagct catccggcag ctcatccgac cgcagcagca gctcatgaat gatacggctg 2929501 ctggctgcga gcgggtcctt gcgccatttc atggaggtgg ttcctgcgtg attgcattct 2929561 ccttcgagcg tgacgagata tcgtctctgc cccgcaatac ttgtcacgat gccgagatcc 2929621 cggcctgaca tttccaacgt cttcccctgt tcaatatgca gctcaacaaa cgcgctgata 2929681 tctgtcctat atgctgactg aaacacacct ttgccaaaac cgctctcatg catcgctgtt 2929741 tggagggaga ctcccgactc gtctcttggc tcttttgcat cttgttctga aaaaacaccc 2929801 gtcatattcc ccgaccccca ataggtcatt ggaaaacggc tgccttcctc ctcacataag 2929861 gagaccgcct cgagcgtttt ttttggcgct ccgtatgttt ccttgagctg ctttaacgcg 2929921 agcattgccg ccagaacgcc ataggcgccg tcgtattttc ctccattgat gacagtatcg 2929981 atatgtgaac cggttacaat gacttcatcc ggagactggg tgcccgaaag ccttccaaac 2930041 acattgccga catcgtcgaa tcttgtttca agcccgaaag aagacatttc cgttttcaca 2930101 gcaagctgtg cgtccatcca ctcttttgtg tataaaagcc tcgttacgcc gccatccgca 2930161 gacgcaccgt attgggcgag ccattcaata taatctgtga tgctgttttt tactgaaagc 2930221 ttctgctttt ccatgtactc ccccctctgg ccgctatggt gacttcatta tagaaggagc 2930281 aacatgatag ttcattgaca gattaaccaa aaaaacgttt attttttagc cacagtatcc 2930341 atccagcaac cagatacacc ctacatgtca caactatttt gatgtaaagg tcaaaagaaa 2930401 acacggtaag gaagagagcc agcaagagcg aaagagaggg tcaaaatgcc tttcatatga 2930461 acaagctaag ctggagaggc gatgttcgcg gaacggatga aaacagaaat gccggcagcc 2930521 cgcaaaaaca ggacctaaag atatggaaac aggagatttc cgcctcctcc aaagggacta 2930581 atttacaatt ttaatgaaaa atatacaaaa tgacacttct atcctttatt tcaattttag 2930641 ataatagata tgatctgata aaaggagggc aagtgatgac aaaaaaagca tggtttctgc 2930701 cgctcgtctg tgtattactg atttccggat ggcttgcgcc agcagcttca gcaagcgcgc 2930761 aaaccacatt aagccttaat gaccgattgg cgtcttcccc ttcaggaacg ggaagccttc 2930821 tctcattagc cgcccccgct gcaccctatg ctgacacaga tacctattat gaaggggctg 2930881 aaggtaaaac aggagactcg ctaaaaagca ccctgcaccg tattatcagc ggacacacga 2930941 tgctgtccta cagcgaagtg tggaacgcgc tgaaagaaac ggatgaagac ccaagaaatc 2931001 cgaataacgt catcctgctc tatacgaatg aatcgcgttc caaaaacctg aacggcggca 2931061 atgtcggcga ttggaaccgc gagcatgtct gggcgaaatc ccatggcgat tttggtacga 2931121 gcaagggacc tggtactgat attcatcatt tgcgcccggc tgatgttcaa gttaacagcg 2931181 ccagaggaaa tatggatttt gacaatggcg gcactgaata tgcgaaggca cccggaaatt 2931241 attatgacgg cgattcatgg gagccccgcg atgatgtgaa aggcgatgtt gcccgcatgc 2931301 tgttttacat ggctgtccgt tacgagggtg atgacggcta tcctgatctt gagcttaatg 2931361 ataagacagg caacggctca gctccttatc atggcaaaca atctgtcctg ctcgaatgga 2931421 ataagcagga tccggttgac gaccgcgagc ggaaaagaaa tgaaatcatt tatgaaaaat 2931481 atcagcacaa ccgcaatcca tttatcgacc accctgaatg ggcggatgag atttggccgt 2931541 aagaaaaagg tgctcctttt gaggagcacc tttttctaat acacagcctc ttccgtttcc 2931601 gcatcgaaaa agacgacgtg gtccattttc actgagagct ggattgaatc gcctgcatcg 2931661 attcgcgtgt ttccgtccag gcggaccttg agccgctcgt ccccagccat gacatgcact 2931721 atgagctccg agcccagatt ttcattcact tccacgttcg cttgaaacac tgaatcaaac 2931781 aactggtcat ttcctgtcat ttgtgtgatg tgctccggcc gtacaccggc aatcatctgt 2931841 tctccggcat atcccttttc cttcagccgc tttgcttttt cttcaggaat atgaagccgg 2931901 atcgaagaat ttgtgaaaaa cagctcgcca tgctgctgtt ctatgatgcc tttcaaaaag 2931961 ttcattccgg gagagccaat gaagcctgcg acaaacaaat tggccgggta atgataaatg 2932021 tcatgaggtt tcgccacttg ctgaatttcc ccttcattca tgacgacaat ccgatctccc 2932081 attgtcattg cttcggtctg gtcatgcgtg acataaatga tcgttgcctc taatcgctgg 2932141 tgcagcttgc tgatttctgt ccgcatcgtc actcttagtt ttgcatccag attagaaagc 2932201 ggctcgtcca ttaaaaagac cttcggctcc ctcacaatcg acctgccaag cgccaccctt 2932261 tgccgctgcc cgccggagag cgccttcggt tttctcttca gcaaatgttc aatttctaaa 2932321 attctggctg ccgcatgaac ccgctcggca atttcctgtt tcgccatctt tctgagcttt 2932381 aatccaaacg ccatattatc aaaaaccgtc atatgcggat aaagcgcata gttctggaat 2932441 accatcgcaa tatcacgttc tttcggcgga agatcattga cccgctcccc atcaataaga 2932501 agatttcctt cagaaatgct ttctaatcca gccaccatcc gcagcgttgt tgattttccg 2932561 catcctgacg gccccaccag caccaaaagc tccttatcct ttacatctaa atcaaagtcc 2932621 ttcacggtta attgtgagtg atatgatttt ttgacgtgtt caaatgttaa tgaagccatc 2932681 agaaaagtcc ccctatcttt tgacccgtta tttcgtcact ggaaacaact tggtctttct 2932741 gttattttta gagtaatcga ttcccatttt tgctatattt ctaaaataaa aaatgtaaat 2932801 ttgtattata acgtcataat acattataat ataaataata ggttaaaagg aggctaccct 2932861 ttgttaaaca acggaagttc tacaccttta tacattcagc taaaacaaat catcactgat 2932921 gacatcaaaa agggcgtgta ttccccaacc gccaagctgc ctaccgaaaa cgagctttgc 2932981 accaagtata acgtcagccg catcaccgtc aggaaagcca ttctcgattt agtcgaagaa 2933041 ggctatctga tcaggcagca gggaaaggga acgttcgtta aaagccctaa attaaaacga 2933101 gagctgatcg ctgtaaacgg ctactcggaa tttatggaat caaccggcaa aaaaccgaag 2933161 catcatgtgc tgtcccatga catcattcca gcgtcaaaac ccatcgccga aaagcttcaa 2933221 atccaacccg agagccctgt ggttgaatta aaacggattt tatataatga tgatcagcct 2933281 ctcacctttg aagtgacgca ttatccgctt gatttgtttc ccggcattga tacctttatt 2933341 gctgacggcg tctccatgca tgatattttg aaacagcaat acaaagttgt acccacgcac 2933401 aatacgaagc tattaaacgt tgtatatgcc caacaggagg aaagcaaata cctggattgt 2933461 gatatcgggg atgcgctgtt tgaaattgat aaaacggctt ttacatcaaa cgaccagcca 2933521 atctattgct cattgttttt gatgcacaca aaccgtgtca cttttaccat caacagcccc 2933581 tacacataac aggcataaaa aacgagacac tgcttatagt attctcgttt tttcactgct 2933641 tcccccgtcc tccaagcgat aaggatagcc atagccgaaa gctccgtaca caccgcaagt 2933701 tttcgcagcc gtttcagcag cctggcgcaa agcatacgtt atatcctgct tcacgcaaaa 2933761 ggcagtcaaa aagcctgcta taaaagaatc tcccgctcca agtgtatcta ttatatcagc 2933821 ttccacaatc ggctgatgat agactcgatc acccgcagac aggattgctc cttggccccc 2933881 tcgggtcata caaaccattt tggctccgta cccatgagct gttttggcaa gctcaccgca 2933941 ttccgactca ctcaaatcgc ttcctgaaaa aaacgcatac gtcacataag gacagaccct 2934001 cctcaaataa tcatcctccc gattggttga aaaatcaaat gagaccggga ccagcccgca 2934061 cagctgcgga agatcgttct caagcctgct gtacacgctc gtatgcagca gatcatgccc 2934121 gctgataaaa gatacatctt tctcctgaaa cgcgaggcga agccgggact gaatgccgcc 2934181 tttatttgat ctgacaaaaa tgcggtcccc ctgttcatca agggtgacaa tcgccatccc 2934241 gttttctccg tgcgcctggc ggatataatc tgcattgacc tgctccagct tgagaacgtt 2934301 caacagatgc gccgcggctt cgtcattgcc gacgattccg atataggaag actcatgccc 2934361 gagccgcttg gcaagcacag caacgtttaa ggcatttcct cccgggtaaa atgtttcttg 2934421 atcctggtag taatctacaa cattatctcc aaccgcaatc aatttcatag cgcttcctcc 2934481 tttatccttt tacactgccg cttgcaatcc cgcggacaaa atatttctgc atcaataaaa 2934541 atagaataat aatcggcgcg gctgaaatcg ttaaccccgc cagcaggacg ccccagtctg 2934601 tctgcagcgc gtctctgaac tgcatcagcc cggctggaat ggtccgtaaa ttctcatcat 2934661 ctatgaaaat aatcgcaaac ataaactcat tccatgtatg gtaagccgtc aaaatgccgg 2934721 atgtcaccaa aatcggcacg ctcattggta agaaaattct gaaaaatact ccaaaacttg 2934781 tacacccatc caaataggcc gcctcctcca attcttttga aatagaaaga aaataagagc 2934841 ggatcaaaat gatggtgaat gggatccgat aagccgcata cggcaagatt aacgcccaat 2934901 acgtattgta caggcccagc gactgaataa tagaataaag cggcacaaga ctgacctgcg 2934961 gcgtcagcat caatccgcca agacatagca ccaaaaagaa tccttttcct ttaaactcaa 2935021 accgggaaag gccatacgct gcccatgcac tgataaagac agtgatcaca cacgtcagcg 2935081 ccgtaacgat gacactgttc ataaaataag aagaaatccc ctgattccag gcggaaacaa 2935141 aattttccgg atgccacgaa gacggcagcg accagctgtg ctcaaaaata tcgtcagagt 2935201 ttttaaaggc gctcatcacc atccagagaa gcggataggc aatcgcaatc agataaagaa 2935261 acagaaaaac ccacacagac gtttctccga tataccattt tcgtctaggc ttatctttca 2935321 cctcaatgtg ctggtcaggc accggctcca atctgaacga atctgtcttc ttctgaggca 2935381 gcatcagtta ctcctccttt ccggttttaa agaacttcat ttgcatgagc gataatgcaa 2935441 gcgtaatgat taacacgaca gtggcaatcg ctgaggcgta gcccatcata tcctttgtaa 2935501 aggcgctttt atataaaaac gtgctcaaga cttctgacgc ttttcccggc ccgccgcctg 2935561 tcaaaatgta cggctcatta aagaccgtaa aggctccggt cagcgtcatg accaccgcaa 2935621 caaaagacat ctctttcgtc tggggaacag taatatgaaa aaactgctga attttacccg 2935681 cgccgtcaag ccgggccgct tcatacagtt catccggtat tttttgaatc gacacgatgt 2935741 acagcatcgc aatataaccg acagattgcc actgggacac aaaaatgaca gaaagcatag 2935801 ctgtgctgtc atccccgagc caggccctcg tcagctgatc aagaccgatg gcctgaagca 2935861 gctgattcaa aagccctgtc tccggattgt aaataaaatc aaacaaaagc gcgatcaccg 2935921 tcattgagat gacaaccggc aaaaagaaaa cggtacgaaa aaacggcgac cattttctga 2935981 ccagcttatc ctcaagcacc gccgccaaaa tcaaaccgcc aaatacctgg catacaattg 2936041 agatcactgc ataaagcaca ttattggtaa gtgcctgata gaagacagga tcatgaaata 2936101 attcaacata gttttttaag ccgataaacg ttttttccgg agaaaatgag ctccactgaa 2936161 acaggctgag gaatacattc tcaaaaatcg ggatataaac gaaaagtaaa aaaacgagag 2936221 cgggcaccaa aaacaaatag gggattattt tattctgatt gaccaagggt atctcatctc 2936281 ctttataaaa agaaaaggtg cgaagcttca ccttttcttt gatttattca gctgacgccc 2936341 tcacctgctt tgctgccttt tgaacggctt tcatcacctg ctgcggtgtc atgtcgccgc 2936401 caagcatttg ctggacgccc gttaggtacg catctgcgac ttcaacatcg acatccatat 2936461 caaaccatgg aaccattgat ttggcatcaa caatatgctg aacggcttca cgctgaatgg 2936521 ctgttgcatt ttcttcagta gccgtacctt gcactgcact gtatttcccg acatctttca 2936581 cgagcttttc gcccattctt ttcgacgtca agaactgcaa aaattccatc gcttccttcg 2936641 gatgttttgt tcttgaggag atcatgaatc cttccggcgc tcccgttaac gcttctgaag 2936701 atcctttctg cccgctgatt tcaggaaatg ggaacatccc gagattaacc ggttcaacca 2936761 gcttgatttc cgctgtttcc gcatatatca tcgccgactt tccgctctta aattgctgtc 2936821 tcacatattc gtggtcgacg gagtttacat gtttattaaa gtaaggcatc agctcttgaa 2936881 gcttttcaag tgcttttacg tagccttcat cagtaaattc acccgttttg gcgttatagt 2936941 ccttttcccg tgttttttca tcgaccatcc gctgattaag cgtgccgata tagtgcgaga 2937001 ttgtccaagt cgcctttgtt ccaaagctga tcggtgtgta gccatgttct ttcagctttt 2937061 ttgacacatc gattaattca tcccacgtct tcgggggatc aagattcagc ttttggaaaa 2937121 tgtctttatt atagaagaat gatttagcgt ccatttgcca cggtacgcca tattgcttgt 2937181 tttcataagt aaatggtgta atttgcgatt gaacgagctg tgatgaccaa tcggtgtcat 2937241 ttttgtagta ggacgagaga tcaagtgctt tattgcctct gataaattta aaagcaaact 2937301 catcgctcca agagaagtaa atgtcaggag ggctggtggt tcccagcatg accttaattt 2937361 tatctttata ggagtcattt aaaacggctt caatttgaat gtcgatatct gggtgatctt 2937421 tttcaaattc cttaacaacc tcttcaaaat aacttttttc cggctccttt ggccatctgt 2937481 ggaaaaattt caatgtcacc tttccgtccg ctgaactgct ttggctcgaa cagcctgcga 2937541 tggtgagcat actgacagct gcaatgatca agaacaacaa cattttcttc aaagggttgg 2937601 cctcctctgg acattagact ataatgttat ataacattat agtctaatgc ataatggttc 2937661 ttcattttca gatcaatact caactttcca catgtatctt ctatgagata aaggatgatt 2937721 tctctcctct gccagctcgt ctgcatagct tctcagcaca cgattgagaa cgagcggagc 2937781 aagatagcct ttaactgaat cgtcaattgc agtgaagtcg taagatgcag catcaagcac 2937841 agtgagcttt ttgccatact ttttcgagaa ggtaagcgcc cgctcttcaa gaggtcttgt 2937901 ttcatctaaa ccgagcagga tgataaacgg cacggattca tcaataattt caaacggtcc 2937961 gtgaaaatat tctccggcat gaatggcgtg ggaatgaatc cattgcattt ccatgagaat 2938021 gcagatgctg taggagtaag cgacaccgta gtttgcaccg cttgccatgg tataaataat 2938081 gctttctttt tcatgggctt ttgcaaattg cttggcgttg tcagcttcct gcttaagggc 2938141 tttttcatat acagcctgca attgatctaa gccttcaatt gcttgctcaa atttcgtatt 2938201 gttttctaat acttgcaggg ttccaaaaac gatttgatac aaaacgccat agtttgtatt 2938261 gatcgcaagc gcctcatcac cccaatcgta ctgggcaaca tattgcgctt cctgcgctaa 2938321 aggagactcc ggtttaaacg tcatcgcaat cgtaagtgcg cccttgcccc ttgcaaacgc 2938381 agcagctttg actgtctccg gggtatttcc cgaatgcgag cacaaaataa caagagactt 2938441 ttcaccaagc tgaacagggt tgcgctgaat aaattcgttg gcgctgtaga gatcggagtt 2938501 tattgatttt gactctctgt caaacacata cttactcgga tacataatgg cagaagaccc 2938561 tccgcatgcg acaaagaata catgatcaat ggttttccct ttcaaatcct gcaagaaagc 2938621 ttgaacctca cgatttactt ttgctgtggc ctgactcaaa tccttcactc ctcgttttta 2938681 ttatataacg ttatataaca ttatatattg ttatattaaa gtccgcgggt aggattgtca 2938741 atattatttt ctgaaatttc tcaataattt attcggatga cagacaaagg gtctatatgc 2938801 gaaaaaatgc ccaaatcaaa agccagaact tgacttaagc tctggcttcg ctgttcaatc 2938861 cgcagactga cgtcttattt aaaaaatacc ttgtctatat tgtacttcga gtgctgtgta 2938921 ttgatgatat atgtttcgta aatctctctt tccattggat catcaactac acatacctca 2938981 attttataaa cttcatctct gtgatgtttg atcggtgaaa cagtgtcttc gaaatgcttc 2939041 ttaattctct gtcttaactt tctggcttta ccgacaaaca gcagctcgtc atgaatgttg 2939101 taaaacataa aaatgccgcc tttgtccctt gggatctggt gaaagtcgat gaatccgtga 2939161 atcggtttta tcttcggctc gttatcatta gctgactgct gtcgttcagt gatggtgaca 2939221 ttcggtgcgg gtatatcaat ttttatcaaa atcagttcac gtcctctttt tcattaaaga 2939281 taaatgctaa cacatacaga aaagaaaagc tagaacagct ttattatatt tgtttgtcat 2939341 gctcttactt attatgcaag tgctccggct ggatcataag gactaaggtc taattctgtc 2939401 tgctttccga gaactagctt tgcgagctct gcacccaaaa acggccccat cgtcagtcca 2939461 gaagcaccca aaccgtttgc agcgtacagg ccttgaacat tcggcacggc ccctacgacc 2939521 ggcagaaatc ccggtgtaaa cggcctgaag cccactcttg tttcaacagc agccgcatca 2939581 gcaagacccg gtgcaacggc taacgctttg ctcaatactt cgtgctggcc tccggctgtc 2939641 acacgaagat catcaagacc ggcatcgttt tcgtgtgtgg cgccggctac aattctgccg 2939701 ttatcaaacg acagaatgta ctgatcactc ggcggcatta caaccggcca cgatcctgta 2939761 tctgcatctg tcatttcaaa atgcataatc tgcgcttttt gaaatgacac ttgaaaatga 2939821 atgccaagag gcttcaatat ctcattggcc catgctcccg ccgtcacaat gaccgcgtca 2939881 gccgcaaact gctttgtatc tgtttgcacg ccggtgactg ttccgttttc aaaaagcaag 2939941 gacgcatttc ctttgatgac cgttgcgccg cgtttctctg cagcgcttaa aagcgaccgg 2940001 cacagcgctc ttccgttcac acgggcggca ccgctgatat gaaccgattc atagccgtca 2940061 gctaaaatcg gaaacagctt tttcgtttca cttgcagaca agcgggtaat gtcgccgatt 2940121 tccggcgcat cctcccgtct cttatacgcc ctttcctcca ttttatcgag tttagacgcg 2940181 tcagtatgaa tgctgatggc accgacacgt ttgtatcctg tatccgattc accgtctttt 2940241 tccaattgat ggattaaatc cttatagtac cgcgctcccc ccttagcaag ctggtaccaa 2940301 tcctgattac ggcgctgcga gagccaagga cagacgatcc ccgccgccgc atcagtcgct 2940361 tgtcccggct ctttccgatc aatgacagta acgcgagcgc ctgtttttgc gagatgataa 2940421 gccgtcgacg cgcccagaat ccctgcgccg acgatgatgt acgatttcat atgcaaacac 2940481 cttttctatt ataatgtcta ttcattttac caaatcaaat gctttccttc gaccttttgc 2940541 cctaatgtgg aaaaaccgcg aagttcgtcc aatctcttta ctctcctatc gaatatcctg 2940601 tcactatcaa tagagaaagg atgataccat gagcgaaaat cgtcatgaaa atgaagaaaa 2940661 cagacgcgat gcggcagtgg caaaagtcca aaacagcggt aatgcaaaag tcgtggtcag 2940721 cgtgaacaca gatcaggatc aggcacaggc gcagtcacaa gacggagaag actaatgaac 2940781 gaaaacatca ttcctcttaa cagacatact caagagatac ccactactga atctgttatc 2940841 aaaaacagcg gcaactcaga ggtccatatc gacattcaca ttgatacaat gccaattgct 2940901 tttgctatat tatgctctgc attagccgca aagcagatga caaaagagga attcgatatg 2940961 gcttatactc aattgcgaga gatgaacaga gaaaataaca gcagatcatc tgtaaagcaa 2941021 attatcaatc aagagacaga agaagagtaa aaaaccgcgg cccctcggcc agcggttttt 2941081 cttctgcata caaaaaggac gcgactgaat cggttacttc tgtacaattt gaataaggtt 2941141 accgcatgta tcgtcgaaga cagctattgt gacttcgccc atttttgtcg gttccgtcgt 2941201 aaacgtcacg cctttttcct ttaatcggtt gtactctttt tgaatatctg caacgccaaa 2941261 cattgtggcc gggaggcctt cggagaatat cttcttttga tactccttgg cggcaggatg 2941321 ttcattcggt tcgagtaaaa gctcggttcc gtcttgatca tctggagaaa caagcgttat 2941381 ccacctgaat ttccccatgg gaacgtcttc cttttttata aacccaagtt tttctgtata 2941441 aaactccagt gccatgtctt gatcttgtac aaatatactg gtaacaacga ttttcatact 2941501 gtttttccct ccttcgatat gaatgaagca tggtactatg ctaacaatct ggctacaagc 2941561 aaaacaaccc acacatttat cagaggccct gttctgattt tataaaatta ttctatccat 2941621 cctttcagca aatttttaag cggttcgttg ttgaatataa gtactcgata ttttcccttt 2941681 cgttttgatg ttacgagtcc tgcatcctcc agtacagaaa ggtgtttagc tatcgcctgt 2941741 cgcgtaatag aaaggtcgta ctttgtaata agacgtatcg taagttcata caacgtcagc 2941801 tcgttgcgtt cagataattc gtctaatata agccgccgag tcgaatcgcc gagtgctttg 2941861 aatatagcgt ctttgttccc attcatatat tgagtataag caacccatta gttgcatgtc 2941921 aagtataagc aactgtatgg ttgcgtgata tagaaactga acctatccgg cgcaggtctg 2941981 aaatattcta atcgataagg aattaaaacc attaaaataa cagtggatat gtctctgaaa 2942041 aataaaagaa gacgaacttc aaaagttcgt cttctacaat caaattcggc acgccggcca 2942101 ttttaaagtt gataactatc tctaaacccc ttgataaaca aaggagtttt catcattaac 2942161 cgatagaacc ttccatttcg aacttaatca aacggttcat ttcaactgcg tattccatcg 2942221 gaagctcttt tgtgaatggc tcgataaagc ccattacgat catttcagtt gcttcttctt 2942281 cagaaatacc gcggctcatc aagtagaaga gctgctcttc agatacttta gacactttcg 2942341 cttcgtgctc caatgaaatg ttatcattta agatttcatt gtaaggaatt gtgtcagaag 2942401 ttgatttgtt atccataatg agcgtatcac actcgatgtt agagcgggcg ccttccgctt 2942461 tgcgtccgaa gtggacgatt ccgcggtacg ttacttttcc gccctgtttt gaaatcgatt 2942521 ttgatacgat tgtagatgat gtgtttggtg caaggtgaat cattttcgca cctgcatcct 2942581 gatgctggcc tttacccgca agagcgatag aaagcgtcat accgcgcgcg ccttcgcctt 2942641 ttaggataca agccggatat ttcattgtca gcttagaacc gatgttgccg tcgatccatt 2942701 ccattgttgc gttttcttca cagactgtac gctttgttac aaggttgtaa acgttgttcg 2942761 cccagttttg gatcgttgta taacggcagt agccgccttt tttcacgatg atctcaacga 2942821 ccgcactgtg aagtgagttt gttgtgtaaa caggcgcagt acagccttca acataatgaa 2942881 cgcttgcttc ttcgtcaaca atgatcagtg tacgttcgaa ctgacccatg ttctcagagt 2942941 tgatacggaa gtaagcttgt agcggtgttt caaccttcac gcctttaggc acgtagatga 2943001 aagaaccgcc ggaccaaaca gctgagttaa gcgccgcaaa cttgttatca gtcggcggga 2943061 ttacttttgc ccagtgctca cggaaaatat cttcattctc tttcagcgcg ctgtcagtgt 2943121 ctttaaagac gatgccttgt gcttcaagat cttctttcat gttgtggtat acaacctcag 2943181 attcgtactg agcagaaaca cccgcaaggt atttttgttc agcttcagga ataccgagct 2943241 tgtcgaatgt ttgtttaatt tcttcaggaa cttcatccca agaacgctct gaacgctcag 2943301 acggttttac gtagtacgta atttcgtcaa agttcagtga gtttaaatct ccgccccatt 2943361 gaggcatcgg catattgtag aaatgctcaa gtgatttcaa gcggaagtca agcatccatt 2943421 gaggctcttc tttcatgcga gaaatttctt ctacgatttc ttttgtcaat ccgcgctctg 2943481 aacggaaaat ggaaacgtcc ttgtcgtgaa aaccatactt gtattcacca atatcaggca 2943541 tttttttagc catccatttt cactccaatc cttttaattg ccgccttctt ctttcgcgac 2943601 tcctttttca agtgctttcc atgacagggt tgcacatttg atacgggcag ggaattttga 2943661 aacgccttga agggcttcaa tatccccgag atctatagaa tcatcatact ctttcccttg 2943721 catcatatcc gagaaaatct tagacatgga aagggcagtt tcaatatctt tccctttaat 2943781 cgcctgagtc atcatcgaag cggatgccat tgaaatggaa cagccttccc cttcaaactt 2943841 cgcatcttcc acgatgtctc cgtcaagctt cattgtcagt ctgatgcggt cgccgcatgt 2943901 cggattgttc atatccacga caatgctgtc atttaaaacc cctttatttc gcgggttttt 2943961 gtaatgatcc ataatcacct gtctgtacaa tgtatctaag tttgcattaa aagacatttg 2944021 taaaatactc ctttgtcttt tgaagagctt ccacaagctt atcaatctct tcctctgtat 2944081 tatacagata aaagcttgct cttgcagtag cagttacatc cagccatttc atcagcggct 2944141 gcgcacaatg gtggccggct ctgactgcga ttccctccgc atcaagcaca gtcgccacat 2944201 cgtgcggatg aacatcatca aggttaaatg tgacaagccc ggcacgctct tccggcccgt 2944261 aaaccgttac gccgtcaagc tggcggaagc gttcaagcgc ataagctgca agcttgtgct 2944321 catggcggga aatctcatca agaccgattt cttcgagaaa atcaatggcg gcaccgaggc 2944381 cgattgctcc tgcaataatc ggcgtacccg cttcgaattt ccacggaagc tctttccaag 2944441 ttgattcata aagcccgaca aagtcgatca tttcaccgcc gaattcggca ggctccatgt 2944501 tttccagcag ggctttcttt ccgtacagca caccaacacc ggtaggtccg cacattttat 2944561 gggaagaaag cgcaaagaag tcgcaatcga gatcctgcac gtcaattttc atgtgaggcg 2944621 tgctttgtgc accgtccacc acaatgacag ccccattgtc atgagcgatt ttcgccattt 2944681 ctttaatcgg gttgaccgtg ccgagaacat tagatacatg agacaccgca acaatttttg 2944741 tgttgcttgt gaccgtttct ctgacgtctt ctaaagaaat cgttccgtct tcctgcaacg 2944801 gaatatattt taatgtggcg ccagttgctt ttacagcctg ctgccacgga atgatattcg 2944861 catgatgctc catgtaggtg atgaccactt catcaccagg tttcaggttg gcgcgcgcat 2944921 agcttaacgc caccatattc agtgatgtgg tcgtgccttt tgtgaaaata atctcagcca 2944981 ttgacttcgc gttaataaac ttgcggactt tttcacgcgc tccttcataa ccatctgtcg 2945041 ctctggttcc aagtgtatgg acgccccggt gaacattgga attgtattgg ttataatact 2945101 tatccagtgt ttcaatgaca gcacgcggct tctgggaagt cgccgcgctg tcgagataaa 2945161 cgagatcatg tccgttcact tgctgatgaa ggatcgggaa ctgttcacga atatctgtga 2945221 tattcattac ttcactttcc tttcgataac agaaactaat tgtttcttaa cgccttcaat 2945281 cggaagttca tttactaccg gtgcaaggaa tccgtaaatg actaagcgtt ctgcttcttc 2945341 tttcggaatt ccgcggctca tcaggtagta aagctgaata gggtccacac ggccgacaga 2945401 tgccgcatgt cctgcagtta catcgtcttc gtcaattaaa agaatagggt ttgcgtctcc 2945461 gcgtgctttt tcgctaagca tcagcacgcg tgattcttgc tccgcattcg ctttagaagc 2945521 gccatgttcg attttgccga ttccgttaaa gatagaagaa gcggaatcct tcatcacacc 2945581 gtgcttcaag atatagcctt cagaagcttt accgaaatgg atgatttgtg ttgtgaagtt 2945641 ttctgtttgc tctcctcttc cgacaacaac cgttttcgta tcgccgtatg tgccgtcacc 2945701 gtaaaggttt gttgtgtttt cggaaatcgt gtcgccatcg ttcatcaggc cgagagccca 2945761 ctcgattttg ctgtcgcgtc cgcgcgcagc accgcggcgg ttcacataag ttgtcacacc 2945821 gcttgacaga ttatccaccg caccgtatgt cacgctggca ttatcacctg tgatgacctc 2945881 actgataata ttgaagacag cgtctttcgg gtttacagtg ctgatgtagt tttctacata 2945941 tgttacagag ctgtggtctt cagccacaat cagcacgtgg ttgaatagag ctgtatcatt 2946001 gctttcgtgg acataaacag cctgaaccgg cgtctccacc tgaacatttt tcggaacata 2946061 aaggaatgct cctccgttaa caagagccgc gtgaagtgca gttaacttat gttcgtcaac 2946121 cttcacgccg tccttcataa agtatttctc caccaagtcg ctgtgctcgc gtgcagcagt 2946181 cagaatatca gtgaagatga cgcctttgtc tttcaattct tgagaaagag aaagatgtgc 2946241 cggcgtctgg tcacgctgta cgtataatgt tttatcttcg ttttcaatgt cgatcagcgc 2946301 ttttacttca tcagtcaaat cttctaatga agaaagcggt tcgttatcca ctgtatgctt 2946361 cgcgaaattc gtgaagttcc agtttgtgat ttttgttttg tcaggtttcg gcatcggcag 2946421 atcctcagct tgttcaagag cctgtaagcg caggttcttc agccaggcag gttcttggtg 2946481 cttttcggaa aagcttttga gatactcctg atctacggat agttttgtac ctagtgtcat 2946541 attaatcccc ctaacgctta cgcttcttgg ccaacagttt cgtcttcaat gccaagttct 2946601 tgtttgatcc agtcataacc ttctgcttca agacgctgtg caagctctgc accgccggat 2946661 tttacaacgc ggccttgcat cataacgtga acaacatccg gagtgatgta gtttaacagg 2946721 cgctgatagt gagtgatcat caggcagccg aagttttcgc tgcgcatttt gttgatccct 2946781 tttgatacaa ctttcaaagc gtcaatatca aggcctgagt caatttcatc aaggatggcg 2946841 attttcggtt caatcatcat taattgaagg atttcgttgc gttttttctc cccgcctgag 2946901 aagccttcgt taagatagcg ctgagccatt tcagggtcca tttcaaggaa ctccatgttt 2946961 tcgtccattt tgcggatgaa tttcatgaga gaaatttcat cgccttcttc tctgcgcgcg 2947021 ttgattgctg agcgaaggaa gtcggcattt gtcacaccgc tgatttcact tgggtactgc 2947081 attgcaagga ataagcctgc ctgcgcacgc tcgtccactt ccatctccag tacatctttg 2947141 ccgtcaagcg tgatgctgcc ttttgttact tcatatttag gatgccccat aatagcagct 2947201 gataaagtgg atttaccagt tccgttcggg cccattactg cgtggaattc tccacctttt 2947261 atttcaaggt ttacaccctt taagatctct ttcccttcga tttcaacgtg aagatctttg 2947321 atcgttaatg ttgaagcagc catatctata cctccaaaaa tatataatca ttattctcat 2947381 tttattctca ttctaatttt ataacaaatg aaaagtaaat acaacttttt atcgtgcctt 2947441 gcacattcct caagtttaac aaagatcagc actttattaa agcgattgaa aaagaaaaag 2947501 agtggattcc cacccttttt taaaagattg attttctcaa taagctcccg cagaaatccg 2947561 cttgcttttt tcataatcaa gctctctctg ccgctctact ttcattcttg tttccagccg 2947621 gcgtccatat tcctcgtatc caattccgtg tgacagctgc atcgcttttt ccatttctga 2947681 cgtataatcg aggttcagtc tgtcctggct gctgcaaata atgaatcaat cccttcatat 2947741 atttgctttt tattgtacca gtgctgcgtt ggatgccgca aaaacgattt ggcgtgaaat 2947801 agcggcagat gagacgaaag catcctttca gaacaaatga gaatggtttt tcggaatatt 2947861 ccttctctta atgcgtggtg tttccgaatt cctcaatgca ctgttgaacg actgtcacgc 2947921 cttggctgaa agctgcgccg cctccaaatg ccgctgccac actgacggct tcgagaatgt 2947981 tttcttctga cgctccctga tcaagacagc cttttgtatg atagatcatg caatattcgt 2948041 cctgagcatt gatggcaatt ccgagggcga tcagctgttt ttctctttca gtcagagaat 2948101 tcccggcaaa gcactgttca gtaaattcgt taaattttct tcccatcagc ggcatctttt 2948161 gttcaaatgt gcctaaacca tgtttatatt gttttaacgc gtcctgcatg cttcctctgt 2948221 cttgattcaa agaaaatccc tccatctgtt taacattcct ttttattatg aacagctttt 2948281 aggaaaatac gcgaaaaaaa ccccggaatt ctcatccggg gtttcagtct tattcagata 2948341 caggaagcac agctccgtcg tattttttct cgatgaagtc tttgatcttt ttagagtgaa 2948401 gaacttccat cagcgctttg atttttgcag aatcttcttc gccttttctt actgcgatga 2948461 tgttagcgta tgggttgttt ttcgttgatt ctacttcaat tgcgtctttt ttaggattta 2948521 atttattttg gatcgcatag tttacattga tgaagaccgc gtctccttct ttgttttcat 2948581 atgcttttgc cgttaattca ggcgctactt ttttgaattc aaggtttttc gggtttttct 2948641 taatgtcttt caatgttgcg tcaactgttt ccactttaga atcaagagtg attaatccag 2948701 cgttttcaag cattgcaagc atacggcctt gttcagcaac gttgtttgtc agaatgattg 2948761 tcgcaccgtc tggaaggtct ttcagtgatt tgtatgtttt agagtaaata ccgaatggct 2948821 ctaagtgaac agcgccggca ttcacaagtt tgtaatctgt gttttctttc atttcttgct 2948881 caaggtaagg aatgtgctgg aagtagttcg cgtccacttc tttatcagct aaagctttat 2948941 tgtacatttt gtaatcacta agcactttca ctttcagcgt atagcctttt tctttcagca 2949001 atggttcagc ttcttttaaa atttccgcat gcggtgtttt tgttgccgca acgacaattt 2949061 ctttcttgcc ggattcagcg ccgttattcg aaccgcaggc agccataact cctgcaaata 2949121 caagcagtaa tgcacccaaa aatagctttt tcaatgtaaa tcctccctta tcgtttgtct 2949181 ataatatttg ttattagatc accgatgatt tgaataataa acacgatgat taaaataaac 2949241 acagtagcaa cgaaggtaac atcagcgtta ttagactgat atccttctac gtacgcaagg 2949301 tttccaaggc ctcctgaacc aatggctccg gcaattgccg ttgaaccgat taaagcgatg 2949361 gctgtaaccg taatgccaga aataagagca ggcattgatt ccggaatcag cactttgaaa 2949421 ataatcgtag acgttttcgc gcccattgat ttagctgctt caatcacacc tttatccacc 2949481 tcacgcagcg cgatttcaac aaggcgcgcg taaaatggtg ccgagccgat taccagcgcc 2949541 ggcaatgcgg cgtttggccc taagatcgtg ccgactaaaa atttcgtaaa acctaatagt 2949601 aaaataatta aaataaggaa cggaatcgat ctgaatatgt taacaacggc tgcaatcact 2949661 gagttgaccg ctttattctg ccagaggctt cctttgctcg tcagaaagag cagcaagccg 2949721 aggatgaccc cgatgacaaa agcaaacagt aaagaaatca gcgtcatata aagtgtttca 2949781 tatgtcgcgt tccataattc agttaaatca acgttcggga agtatttttc aaacattcgt 2949841 gatcacctct gctttcacct gtttgtcatt aatgaatcgg atcacgtttt gcacttcttc 2949901 ctcgtccccg tcaatgtgga tgaacagtga accgtaagcc ccatccttcg tctgcgaaat 2949961 tttcccttgc agaatattga cgctgacatt gaagtttctg atcatctctg taatcagagg 2950021 ctgttcagct gactcaccga caaatgtgag ctgaaccatt tttcctgatg ctgtatcatc 2950081 aagaaggtgc tgaagcgtct ctttcgtttc ttccggctct gtcacctgtt gaacaaatcg 2950141 ttttgtcatt tgttcctttg gatttttgaa gacatcgaga acctcgcctt cttcgaccac 2950201 cttgccgttt tccatgacgg cgactctgtt gcagattttg cgtatgacat gcatttcgtg 2950261 cgtaatcagc acaatcgtca aaccgagtct ttcattaata tcggacaata gatccagaat 2950321 tgaatctgtc gtttgcggat ctaatgctga tgtcgcttcg tcacaaagaa gaaccttcgg 2950381 attgtttgca agcgctctgg caattccgac acgctgcttc tgaccgccgc tcagctggga 2950441 cggataagat ttttcttttc cttctaaacc taccagttta atcagttcat tggcgcgctt 2950501 gatccgctcg ctctttttca ccccggcaat ttctaaagga aacatgatat tatctctgac 2950561 agtccgcgac caaagcaaat tgaaatgctg gaaaatcata ctgatctcat ggcgtgcttt 2950621 tcttaaaccg cgtccattta cttcattaat cttggttccc gccacttcca cggttcctga 2950681 ggttggtttc tcaaggccgt tcagcagacg gattaaggaa ctcttaccag ctccgctata 2950741 tcctataatt ccaaaaatct cacctttttt aatggaaagc gagacgtttt ggacagcatt 2950801 gacatctcca tgtttcgact tgtaaacttt tgaaacatcc tgaagattga tcaaagcaat 2950861 cacctgcctt aacactattc taagaaatct tccggttttt tctgcaaaag aaaagccttt 2950921 ctgcacactt gagcagaaag gcttatataa aatgcctttc tctcatcttt caaagctgaa 2950981 cgcttcgtgt gaattggcac catttcaaca gtgttgatgg ttgccgggct tcatagggca 2951041 cttccctcca cctctcttga taagagaaat atatagtctt tttcgtccgg aaattcttaa 2951101 tgtagaatag cacggcgaat gattaaatgt caataaaata aatgatgtca acttttacta 2951161 ttataataat ttattatttt ttaatttttt aaaatcctct gaaaaaatcc atttgtcagc 2951221 cagagaatgg cttccagctt taacagggcc ctgaatgacc cctttacttt gaggcttccg 2951281 ctctgaataa ggtgctgaag ggaaatgtct ccgtgcaata aatcaataat ttccgtttgg 2951341 tttccgtaaa aggtcaggtt ggacgtttgg ggcggagaaa cttttttcat ttctccctgt 2951401 tcgtttattg agacggttaa ggcttctgct tctccttgga aggtaatgag caatgttgag 2951461 gcattcaaaa ggggttttaa aaacagatgc tgatactcat cttctaaaac ttccgctttc 2951521 tccatatgta caacctccta tttgttggtc atacatacac atttctctct ttgtcgcaag 2951581 aaccccttta taaaacgaac gacaatttca ttggatatgc tgagaaatat gtcataaatg 2951641 ggatgcggaa gatgattttt gtttgatcag ctcatataaa taagaaacgg aatgaaatgc 2951701 atatcctctt tcgaccatct ttccgccttt aaacagcaga aaacaaggga cgctttcaat 2951761 ttgatacgct tttgcgaatg tcggagagta attgacattg ttttgataga aggcgacatc 2951821 cggcagcatt tctttcacca ctgtcagcat tttgcttgca agctggcagg tgccgcaaaa 2951881 cggagtatat aaatatagaa ggtacacatc atcttcaatg tgatcaagtt cgtgttcttg 2951941 gagttctttc atgctataca cctcgggact ttctttcaag aaaaatagta tggacattca 2952001 gattcgcacg cagcaataca gaagcgatat ggtgcctggg cgcagccgct acttccttat 2952061 aggctctgtc gacatggaga tggcaggctt cattaaattc acgcttcagc tgttttctca 2952121 atttctcacc tgattcatca gcatcaacta atatatagac gtctttatca taaagctcgt 2952181 cagccaattc ctcgagcctc agctggctga ttgttccgtt tgtgcagata atgcgcatcg 2952241 gttcattcag gacgctttcg attttctctt tatctgattt cccctcgaca atcataacct 2952301 tttccagctc atccatcttc atcttgttca cctgccgcgt caaatttgaa atgttcagat 2952361 tgtaaaagaa ggcagtgaaa ttcaccgcca acattaacac cagccgtttt cgtagtcaca 2952421 atctacatat tttgcgtcgt ctccagagac cacatcggct gtcttataaa atttctcatt 2952481 ttcaaaggaa taaccggact taagctcata ttcattcatg cttgtcattt ggccgatcat 2952541 ctcattatca tgatataacg agagccggcc attttgaaag cggcctgtca cgtcattggt 2952601 gacatcgagc ttttgtttgt cgaaagccat attggacacc tcccataacg ttagcgtgtc 2952661 caattgcttt tacggctatc ctgttttagt cttcttgtgt catctcttcg tattgctctg 2952721 ctgtcatcag tttttcaatt tcagaagcgt cagatggctc aacgacgatc atccatgctt 2952781 tttcgtacgg agattcgttg acgaattccg gactgtcatc aagatcttcg tttacttcca 2952841 caaccgttcc gttaatcggt gcataaagct cagataccgt tttaacggat tcaacactgc 2952901 cgaatggctc gtccgctttg atttcagcgc ccacttcagg aagttcgaca aacacgatgt 2952961 cgcctagttc ggactgggca aaatgcgtaa ttccgattct ggctttttct ccttcaactt 2953021 ttacccactc gtgttctcct gagtaacgca aatcttttgg tatgctcaat tgaatccctc 2953081 cattttttac agcactacaa taagaagata ccacactttt caaaaaaaat ttacattaag 2953141 cccagttttc ttcaaattgg tcttctttaa atccgacagt cactttttcg ccgtctgttg 2953201 taagcgggcg tttaattagc ataccatctg aagccagcag ttcgagctgt tcgtcctctg 2953261 acatatgata cagcttttcc ttgagattga gctcgcggta tttcatgccg ctcgtgttga 2953321 aaaatttctt gagatccagc ccgctttttt cataaagcgc ttttaattct tctttgcttg 2953381 gcggctgctc agcaatatgt atttcgttta tttctttccc atgctcttca agccacttct 2953441 ttgctttgcg gcacgttccg catttagggt accagtaaaa agttaacgac atcttcttcc 2953501 ccctcaataa aataatcgag gttattttaa cacagtttgt tttaaaaacc taaaacagtg 2953561 cttcttaaaa aagagctccg cgcatgcgga gctcatggcc aatcagacag tatatttctc 2953621 agcctcaaaa atgcctgccg ccgcctcgcg ttttttctga atcacgtttt taggcgttac 2953681 gcgtgtcagc ttgcgcagag cggaaagcat catgcggagt gaatctcctt cttccattgc 2953741 gataagggat tcctttgcat gcgcttcgat ttcgttaaag gcctcttgaa cgaaaatttc 2953801 tgtgtacagc accttttgcg ctgctttttc agcgccttgt gcggcaatgg ccttttccgt 2953861 tctgagcacg gctgattcca ttgcgtatac attgctgacg atatccgcta cgttcacgag 2953921 aatttcttgc tcacgatcga tcgcttttcc gtatttttgc gcggctaggc cggcagcaaa 2953981 caacgcaatt tttttggctt gcttgacgat atatttctcc tgctctaaga cgccgcttcc 2954041 aggctcttca ggcataagca tcatgagttc ttcctgcagc gactgcgctt tttcgaataa 2954101 aggcagctcg cctttaagcg cttttttcag gaaggtgctt ggcacgatta accggttgat 2954161 ttcgtttgtg ccttcaaaaa tccgattgat ccttgaatcc ctataggccc tttctacttc 2954221 gtattcctgc ataaagccgt agcctccatg aatctgcacg ccttcatcaa cgatataatc 2954281 aagcgtttca gagccgaata ccttattcag agagcattcg atggcgtatt ccgcaatcga 2954341 tttggcgatt tgccggccgt ccttgagatc ttcggccgtg aactggctca tattgtcttc 2954401 aaacagcccg acggttctgt atacagagct ttccatcgca tacagccttg aggccattgt 2954461 cccgattttt tcctgtgtca atgaaaaacc agcaatcggc gttttaaatt ggcggcgctg 2954521 atttgcgtat gccgcagaca gctcgatgac gcgtttagat gcgccgattg tgccaaccgc 2954581 cagtttgtaa cggccgatgt ttaaaatatt aaaggcgatg acatgccctt tgccgatttc 2954641 tccgagcagg ttttcctttg gcacttcagc ttgatccaga atgagggttc ttgtcgatga 2954701 tcccttgatt cccattttct tttcttccgg tcccgtggag acacccggga actctttttc 2954761 tacaataaag gctgaaaact tgtcgccgtc taccttagcg taaactacaa atacatcggc 2954821 aaaagcagag ttggtaatcc actgtttttc ccctgttaat acataatggg ttcctgcttc 2954881 attcagcaca gctgttgttt ttgctccaag tgcatcagac ccagagccag gctcagtcag 2954941 agcataagcg gcgatctttt cgcctgaagc gagtccaggc aaatattttt tcttttgttc 2955001 ttctgacccg aaaaagacga tcggcaagga accgataccg acatgcgcgc cataagaaag 2955061 agaaaagctt cccgcacgcg aaaatttctc agtgatgagt gccgagctga ttttatcaag 2955121 gccgagcccg ccgtattctt ccggcacatc ggcgccaagc agccctagtt cgcccgcttt 2955181 cttcaacagt ctgacagaat gctcgaattg atggttttcg atatcatcta tatgagggag 2955241 aacatcttgc tcgatgtaat cctctgttgt tttcgcaatc attttatgct cgtcagtgaa 2955301 atcctccggt gtatacattt gatcgtatgt gacatcctcg attaaaaatc cgccgccttt 2955361 ttgtacgtca gccgcttttt ttgccatttg tttttccccc tttagcataa ttcaaataca 2955421 ccggccgctc ccattccgcc gccgatacac atggtcacga ctccaaattg ctcgtttctc 2955481 cgtttcattt catggatgag tgagagtgta agctttgtgc ccgtacagcc aagcgggtgt 2955541 ccaagcgcga ttgcgccccc gttgacattc actttttctt catcaattcc caattccctg 2955601 attacttgaa tggcctgtga ggcaaaagct tcattcagtt caaacaagcc gatgtcctgc 2955661 agctgaagtc cggcaagctt caaagcgcgc ggaatcgctt ccaccggtcc gattcccatc 2955721 acttccggcg gcacgccgcc taccgcaaag gagcggaatt tcacaagcgg cgccaggcca 2955781 agagcatcgg ctttttcccg gtccatcagc atgacagccg ccgctccgtc actcgtttgt 2955841 gaggaattgc ccgcagtcac cgtcccgtca acggaaaagg ccgggcgcaa tgtcgataag 2955901 atgtctgcag tcgtttgcgg gcgaacacct tcatcctgag aaaacacaaa ctgtttttcc 2955961 ataggcttat ggtcttctcc gatttctgtc accgtcactt cgacgggtac aatttcatct 2956021 ttaaattttc cttctgcaag ggctttagcg gcgttttgat ggctgcgaac ggcaaacgcg 2956081 tcttgatcct cacgggagac gccgtatttt ttcgcgactt gctcggctgt gtgccccatg 2956141 ctcatataat attccggtgc cttttctgcc aaagcaaggt tcggacgggt aacatgcccc 2956201 atcatcggaa cttgcgacat ggattctgct ccgccggcga tcgctgtatc gtaggcgccc 2956261 agcataattt tttctgctgc atacgcaata gactgaaggc ctgaagagca atagcggtta 2956321 actgtaatcg ccggaaccgt gtacggcagg cccgcgagcg caccgatatt tctcgccata 2956381 ttaagcccct gctccgcttc aggtgttgca cagccgataa tcaagtcatc aatattgcct 2956441 tcgtagccgc ctgcccgttt cagcgtttct tttacacaaa tcgctcccaa atcatccggg 2956501 cgaacggtgg ccaacgatcc tttttttgct tttccaaccg gtgttcttgc acctgacaca 2956561 atgactgcct ctttcataag ctccctccta attccgtaaa ggtttacctt tcacaagcat 2956621 atgctgcatt ctcgcttgag attttgcctc tcctgacaaa ctcaaaaacg cttctctttc 2956681 gatctccaat aaatactctt catcaacctc tgtaccaaac ggcacttttc cgcccgcaat 2956741 gacataagcg agttttttcg cgatcttaaa atcatgctca gatatatagc cggacagctt 2956801 catctgctca gcgccaagca agagtgccgc ataaccggtt tctcccggca ccttgacctt 2956861 ttcttttaca ggcggccgcc agccggtatc gtataaagat gcggccagct gcttcgcatc 2956921 gtataacagg tggtcttgat tcacgctgat ctgatccgtt tcttttaaga tgttcatctc 2956981 acgagcctct tgagcggaag cggacacttt cgccatcgcg attgtttcaa atgttttcat 2957041 tgccgcattc atcggatcat ggccgcggcg aagatggttg atgtacagct ctttgttacc 2957101 tcctccgcca gggatgaggc cgacaccgga ttccacaagt cccatatagg cttcgcttgc 2957161 cgcttgaatg cgcgccgccg gcaggcatgc ttccgttcct ccgccgagcg tcatgccaaa 2957221 tggcgcggcg acgaccggtt tcgcactgta tttgatcttc atcatcgtct cctgaaaacg 2957281 gcggatcaca aaatcaactt ccaaaaagtt gtcatcttgg acttccatta agatcatggc 2957341 gagattcgcg ccgacgcaga aatttttccc ttgattgccg atgacaagcc ccttgtaatt 2957401 ccgttctgtt tcctctaatc ctttgtggat catttgaatg atatcgaggc cgatcgcatt 2957461 gcttttcgaa tgaaattcaa gaagggccac atcatctcca aggtcaatta agcttgctcc 2957521 gctgtttttc gcaatcacgc cttttgtttc tttaagtgct tgtaaatgaa ttcgtttttt 2957581 gttttctttc acggctctgt attcgccgcg gtcataataa aataccgttc cgttctcttt 2957641 gatgtagaag gtttcatttc ctttgtccag catctctttt atccagccag gcatatctgc 2957701 tccaagctgc tcaagctttt ccgctgactg cttgaggccg atggcgtccc acatctcaaa 2957761 aggtcccagt tcccagccga atccccactt catggcttgg tcaatcgcat gaatatcatc 2957821 ggcaatctcg ccaagcagct cggctgagta aagcagggtt tgagaagtga tattccacag 2957881 caaacggccg gccctgtcat ccgaataaat aagcgctttc attttggctt ttgtcccttt 2957941 tgcctgtttt gccgcttcaa gtgccggtga tttcattttt gtccgctcgc cgtaagtaag 2958001 cgtcactggg tcaagctcat aaatcgtttt tccttctttt ttataaaagc cttggccggc 2958061 cttgcttccg atccaccctt tttccagcat atcgttcatg aagcttggaa tgcgaaacac 2958121 ttctttttca tcgccatcag ctttgtcata cacatttcgg gcaacgtggg cgaatgtatc 2958181 gaggccgacc acatcaagcg ttctaaaggt ggcgcttttc ggcctgccga tcagcggtcc 2958241 tgtgatcgaa tcaacctccc cgacctgata accgcctttc agcatttctt ggactgtcac 2958301 gagaagcccg taagtcccga tgcggtttgc gataaagttc ggtgtgtcct ttgctgtaac 2958361 aacgcctttc ccgaggacat tttctccgaa agctgtcata aactttaaaa tatcaggatc 2958421 cgtttcctta atcggaatga tctctagcag ctttaaatat cgtgcgggat taaaaaaatg 2958481 cgttccaaga aaatgggctt taaaatcatc cgaccggcct tcagccattt cctgcactga 2958541 tatgccggat gtgttgcttg agacgatgct tccagtcttt cgatgttcat ccacaagagc 2958601 gaaaattttc tttttgactt caaggttttc gacaacgacc tcaataatcc aatctgcttc 2958661 tttcagtttt tctgcatcat cctccagatt gccaggtgta atataggagg tatttttcgc 2958721 tgatgtgagg ggagcgggct tttgtttcag cagttttttc atcgcctgcc ggctcagcct 2958781 gctgcgcacc tccgaactgt ccttcgtcag cccctttttt tcctcttcct ttgtcaaatc 2958841 gttcggcaca atatctagca gcaggacagg aattccgatg ttagccaaat gcgccgctat 2958901 cccggaaccc attacccccg atcctaaaac ggctgccttc cgaatgtgtt tgtgcatgag 2958961 atatccccct tgaacattga atgaatagtc attcattttt tgactaaaaa aaatgaaacc 2959021 cgtttcttct ttcatcttaa aagatttccg gttcgacttc aatagctaat ttgttatttt 2959081 tttgtatgaa gcctataaaa gtcgggcaac ttaagcccgg aggtgaaggg aatggtacga 2959141 gagaaaaaaa atccgtcttc agcggcagtc agcgcggcga gcgtaaaggg agatgccggt 2959201 ccgactcagc attacggcgg cggaaaacgg acaagtcaaa atcagcagta taaaaaacat 2959261 aacatgggac aatcataatg cagctgcttc ccacggctgc tttcactttt tcaaaattcc 2959321 ttttaacaca aacgctgcat tggcaggccg ttcggcaatt cttctcataa agtagctgaa 2959381 ccagtccgtt ccatatggga catacacacg cattctgtag ccttccttgg cgagttcctt 2959441 ctgacgctcc ggcctgatgc cgtatagcat ttgaaactca aattgcgatg cggggatttg 2959501 atgttcggcg acgagctgtt tcgtaaatgc aatgatgtca tcgtcatgtg tggcgacagc 2959561 cgtgtagttc ccgcttaaca actgcagctt tattaagctc tgaaaatgaa ggtccgtgcc 2959621 tcttttgtcg ggaaacgcta cagccgcaga ttctttataa gcgcctttta caagtctgag 2959681 attcggcttt aagtcccgca tctttctgat atcttctgcc gcccggtaca aatacgcctg 2959741 aatgaccgtg ccgagcttct caaattcctg tttgcattgc ctgtaaatag aaagtgtctg 2959801 ttcataatga gaatagtctt ccatatcaat ggtcacagca acatcatatt gcttcgcaac 2959861 ggaaagaatg gcgcgcaaat gagtaagagc aagttcttct gaaagatcga gcccgattga 2959921 ggtcagctta agtgaaagct ctgaattcaa ttgatgttcg gcaatggctt gaatggcttt 2959981 cttgcattcc tctgcgactt ggtttgcttc tttttccgaa gctgcatact cgcctaaata 2960041 atcaattgtt gcacacaaac cggatctgtt tagccttttg acggtcttaa ccgccgattc 2960101 aatcgtatcc cctgcgacaa accttcgtgc tccaagccgc gttccgtatg cttttgcgaa 2960161 cttggtaagt gttttatttt gagataagaa taaaaacaca tgtctcaaca tccgactccc 2960221 tcccgccgtc atcttcaaaa cacctgtata taactcccag tctgaaggaa actataaaat 2960281 gaacagaaac caaaggagga tcacaatgga taatcagcag caatctcaaa tgccgccttc 2960341 cgttatttcg acaaaggatc atttgtatct caatgacatg ctgaactgga atttgctcgc 2960401 gatgaaaaaa gcgcatttca tggcgcagca gtgccaggat caaacgttaa agcaagaact 2960461 cgaccgcgtc ggacacatgc atcatgatca ctatcaaaga atattaaagc acctgcagcc 2960521 aggccagcag cagtccggct acatccaata aggaggcgcc agaatgaatc agcaaaatca 2960581 aaaaatcagc aacccgcaga cacctgtacc gacaacatcg gaaatgaatg acagagattt 2960641 cgtcaacgaa ttgctgacaa ccgaaaaata catgacaaca gcttattgca ctgccttgca 2960701 cgaattcagc cacgagtctc tttatcagga tattcaatcc atttttgatg agtcacaaaa 2960761 agcgcaaaga aaactatatg atctcatgtt ccaatatgga tggtattctg ttgaagcgga 2960821 ggattcacaa aagctgcagc agtcctatca aaaattccag cagaccattc agcagcagtc 2960881 tccttatcag caataacaac attagtaaaa aggatacgat gttctttcgg gcatctatcc 2960941 tttttttgtg taaaatcagt tgacttttca tttacgctta tttatattta ataagcatta 2961001 actattttgt cattaaaata tatatacagt gtatgtaaca gaggggaaat gaatatgaag 2961061 agtgcggatc agttaatgtc cgatattcaa ttatcgcttc aggcgctctt tcaaaagata 2961121 cagcctgaaa tgctggaaag catggagaaa caaggtgtca ccccagcgca gctgtttgtg 2961181 ctggccagcc taaagaaaca cggcagcctc aaagtttctg aaattgccga gcgtatggag 2961241 gtgaagccaa gcgcggtgac gctgatggca gatcgccttg aacaaaaaaa tcttatcgcc 2961301 agaacacaca acacaaaaga caggcgagtg attgatctca gtcttactga cgaaggagac 2961361 ataaagttcg aggaggtttt ggcgggcaga aaagccataa tggcgcgcta tctttccttt 2961421 ttgacggagg aggaaatgct gcaggcggcg catattacag caaaactcgc acaagcagca 2961481 gaaacggatg aaaagcaaaa catgaaaaga ggaaacggat gaaaatgagt aaagaaggca 2961541 aacaatcaaa acgaacgtta ttaataacag gcttaattat tgccatgttt ttttcagccc 2961601 ttgacggtac cattgtcgga acggccatgc cgaaaattgt cggtgatctg ggcggtttga 2961661 gcatgatgac ctggctgaca actgcatatt tgttaacatc aacaaccatt gttccaattg 2961721 ccggtaaact ggctgattta ttgggacgcc gcattgtcta tgtatcaggt ttgattattt 2961781 ttatggccgc ttctgctttg tgcggaatgg ccaacaacat gacggaattg attatcttcc 2961841 gtggactgca gggcatcggc ggaggcatca tgatgccgat ggcgatgatt gtcatcggtg 2961901 acttgttcac aggaaaacag cgtgctaaat tccaaggtgt ctttggcgca atttacgggc 2961961 tggcttcagt gattgggccg caaatcggcg gctggattgt agactcgtta aactggaaat 2962021 gggttttcta tattaacctg ccagtcggaa ttattgcggt tatttttatt gccaggggat 2962081 tacagggacg ccagcagact ggtccgatca acttcgatat cgctggtatt ttcacaatga 2962141 ttgtcggtgt ggtcagcctc ctgctcgcct taagctttgg cggaaaagat tatgcatggg 2962201 attcatggca gattcttggg ttgttcgctc tcgcactgat cggcattgtc agctttatca 2962261 tcgtagaatc aaaagcaaaa gagccaatcc tgccaatgta tttatttaaa aacagaacat 2962321 ttacatttct aaacttgatc ggcttcttta tgagtatcgg tatgtttggc gccattacgt 2962381 ttgttccttt ctttatgcag ggaattgtcg gtgtaagtgc gtctgaatcg ggtacaatta 2962441 tgacaccgat gatgatttct atgattatca caagtatcat cggcggacag cttgtttata 2962501 aaattgggat taaaccgcaa atcattacag gcatgctggt tatggccggc ggattcctgc 2962561 tgttaacgac attggatctc gacacgagca agcttgtcgc tacatctttt atggcgatta 2962621 ttggtctggg aatgggtctt gttatgccga ttctgacatt ggctttacag gaaagctttt 2962681 cgaaggagga gcttggagtt gtcacttcat ccagccaatt cttccgttct atcggcggaa 2962741 cattcggcat taccatgctg ggagccgtaa tgaatgcgag atcaggaaat ctattaacag 2962801 ataaattggt tccatattta gactctcttc cggcacaggc aagctcgttt gccgcccagc 2962861 taaagggtat gattgataca aatccgcaag ggctgctgca atcactgttc agtccggacg 2962921 cggtcaaaca aatccctgcg gctttctcat cccatattgt gccgatttta aaaacatcgt 2962981 tgatggattc gctccacagc gtgttttata cgggcctgat ctttatcgca gtcggagccg 2963041 tattcacctt gttcttaaaa cctatcaagc tatcaaataa gaaagcggaa gaccaacaag 2963101 aaaaagagaa ggcggcaaaa gccgttgaat caccttccca ttaatagagc accccgcggg 2963161 tatcaatccg cggggttttt tattcaatca tctgggctct tccatttccg aaagaccaat 2963221 cctcatcctg atttccggcc agcatgataa acacatcttc ttttcttaca ccaagctcgg 2963281 aatgaatccg gctcgcgatt gagcggtaaa gtgctttttt ctgttcagtt gttcttgact 2963341 gtttcagtgt aaaatgaatg tatatcagtt catcagtacg ctcgacttgg agataaaatg 2963401 gatcataaaa aaattcgctt ttttcatatt gtctgatgac ttggaaatag tcatcttccg 2963461 gcacattgat ttcttcaatc atcgattggt ggatagtcct gctcagtttt tgaagccaca 2963521 cttcgcttct tcccgaccgt aaatgaatct gtacaaatgg catctccccg catccctttc 2963581 tttacagcgt ctgtccgctg tcaattgtga taatttggcc tgtgagtgat tcctgttcaa 2963641 ttagtgaaca aatcaatttg gcaacatcat ctggttcagc aatacactgc agcagcaaag 2963701 agccgatcat gcttttcatt ttttcttccc gtccggccca ccatctcgtt gccacagctc 2963761 ctggtgctac accgctcact ctgatttcag gcgctaaggc gtgggccaat gatttcgtta 2963821 aaccgtgcac cgctgatttt gatactgcgt aaggcattga tgagccggca ccagttatcc 2963881 ctgcgatgct gccgacgttt acgatcgccc cgtccttgct tttcttcatg aacggaacca 2963941 ctgcccgcgc gcagaaaaac atccctttca cattgacggc atacagctca tcctagacgt 2964001 cttctgtcgc agcctcaaga tcatccattg gaatatgccg tgtaatgctg gcattgttga 2964061 ctaaaatatc aaccgtgccg tgtgtgttca cgattgcttg aatcatatcc tgcacgtcgc 2964121 tgtttttgga tacatctgct tggatggcga aggcttgccc gccagctttt tgaatcattt 2964181 ccactgtttc ctccgcttct gattgcgagc gtgaataatt caccgccaca atcgccccac 2964241 gctttgccaa ttccatactg gctgcttttc cgattcctgt gccgcccccc gttacgagag 2964301 ctattttgtt caagacattc attgccgcca ctccttgctg ttgactaaag tatatttctg 2964361 attccattgt aatccagctt tgatgttacg tataatgatt gttaaagata ctagatatca 2964421 ctcagattga tagtaaacga acggaggagt tcaaaatgga aagcggagat ttacgtgtgt 2964481 ttcaaatggt agctcgtgaa gggaccatta cgaaagcagc cctgcagctt ggctatgtac 2964541 aatcgaatgt cacggccaga attcaacaat tggaagctga gctgggtacc acactgtttt 2964601 tgcgccataa tcggggcatg acactttctg caagcggaaa attgctgctg gactacgcaa 2964661 ataaaattat aggccttctt gatgaagcgt ctaaagcgct ctcatcctcc gcagaaccaa 2964721 gcgggccgct tatgatcggc tgcactcaga caaccgccgc ggtaaggctt ccaaagcttc 2964781 tggcatctta ttatgaagaa catccaaacg tccagctgtc tttaacaaca ggacatacgc 2964841 aatttctcct tgataaagtt cttcgttatg aattggatgg cgcgtttatc ggatgcgaat 2964901 gccatcatcc tgagctcgaa tcctatcctg cgtttgagga agaaccagta gttgtttcgg 2964961 ctgcctccgt gcccgatgtt gaggaagcca tcacaaagcc gattctcgtt tacagcacag 2965021 gctgttcgta tcgagaaaca cttgaaaaat ggctgcgttc cgtcggtgtc acacagccgg 2965081 tcattatgga atttgggacg cttgaagcaa ttatcggcgg ggttacagca ggtcttggca 2965141 tctcgttgct gccaagaacg gttgtgcaga aacatgaagc agaaggatca attcgattgt 2965201 acccgctgcc tgaagctctc agccagatga aaacagagtt tattgttcga aaagattcgt 2965261 ttatcagcag cgcgctgaga acctttatgg attcctttac gccagttaaa acggctgaat 2965321 cacaaaaaag cagtctgcta taatgaacag actgcttttt ggctattgtt tgtttcgatg 2965381 cgcttcattt aattccttaa tatgctgaat gatctcttta atgccctgct tcgcgtcggg 2965441 gtatgtcgca ttccaatgct tagcgagcgg aggcatgctt ttggctatat gggtgtacaa 2965501 aatccattgc ttcacttctt cttttagctc atcgtttgtt tcaccaagca gaagctcagt 2965561 atacttctcc agcaatccat caagctgctc ctgaagtttt tgttccattt tccatcttcc 2965621 tttcgaaaaa acagcaagga gctttctcaa ttgaaagctc cttcgctgcg ttatttatcc 2965681 atgtgatgtg aaagccgctt cctggacaat gcatctgccc ctgccatgag gaatgcaaag 2965741 aggcgttccg aagagcgggt cctgtgtaac ctgacagttc atagaaaaca cattttgcac 2965801 aagatcacaa gtgatgacct cttccggacg gccttctgca taaatccgtt tatcttttat 2965861 ggccacaaga tgatgcgcat agcggcacgc caagtttaag tcatggagaa ccataacaat 2965921 cgtccggtct tccttttcat tcagctcaaa cagcaaatca agaatttcaa tttgatgcgt 2965981 catgtctaaa tacgtcgtcg gctcgtcaag aaggatgata tccgtttcct gggcaagcgt 2966041 catcgcgatc caagcccgct ggcgctgtcc gcctgacaaa gaatcaacgg cacggtcagc 2966101 catgtcctca agctttgttg ctttaagcgc tctttcaact gcttcctcat cctcttttga 2966161 ccactgcttc agccagtttt ggtaaggata tcttccttgc ttcaccagct gatgcaccgt 2966221 cagcccctct ggagccgaag gaccttgggg caggattgcg agctcttttg cgacttcctt 2966281 cgtcggaagc ttggcaatcg ctcttccttc cagcagcact gaaccgcctc tcggcttcat 2966341 caggcgcgct aatgaacgta aaagtgtcga ttttccgcag ccattgctgc caataaatac 2966401 ggtaatttca cctttgggaa ttgttaaatt caactcatca ataataacgg catccccgta 2966461 tcctaagctc agcgtttctg tagaaattgc actcataccc ataaccgctc ctttttgctg 2966521 gctttttagc agcactatgt attgcacgtt ttctatatac atgcttttaa gtcaattgtc 2966581 atcaatgcaa atgattccga tattcagcca tttgatatgg tcatatatcc ctcattgtag 2966641 cagaaaacac tgactttgaa aatcattttc aattagtttt atggacataa ttgacgttta 2966701 tgggtttttt atcacaagat tacttcttga tttctctgat ggagccgtcc ttcagcttca 2966761 attttaaatc gatatgatca taatgactgt ccagattaaa tgctgccagc acactgtgta 2966821 tcacttctgt ttcagccatt tggtctgtca cggaaagctc gctcaaaatc attttcatct 2966881 catctaacgc ttcttctcct tcctgattga caccggagag cttatcctgt atttccgctt 2966941 tttcctgagt cccgttcttt gtatagattc cttcataacg gttatgctca ccatccccgt 2967001 agctcacacg aagcgaaaaa ttactgtagg gaacggactt cagctgggtg acggctgtat 2967061 tttctccttc tgcctgatgc tggtcttcat tgaaacggca gcccgcaatc agaaccactg 2967121 cgagacatac agccccggct gctctgatca aatgcatatg tttcccccct gtaggattcc 2967181 atttatttta ggtatatcca gagaatgaaa tcctcattca gagaagaatt gaaaaagccg 2967241 gggcatttaa cgccacggct ttttctttaa gattcggtca tttgtaaaaa ggtttcggcg 2967301 tcacgcacag ccagcttgat ggcattctcc cagaaatcgc gctttgtgat gtcagcgccc 2967361 aaatgcttca tcgccaaatc ctccactgtc atagaagccg tatcgcgcaa tagcgccata 2967421 tacttctctt cgaatgtgtc tttttcttca agcgccaacg cgtaaatacc aagagaaaac 2967481 aggtagccga atgtataagg gaaattgtaa aacggcaccc tcgtgatgtg aaaatgaagc 2967541 tttgatgccc aaaaaagcgg atgatattct tctaacgcat tgcagtatgc ctctctttgc 2967601 gcctcttcca tcagctcatt caagcggctg gccggtacca ctccccgctt tcgttcctcg 2967661 tagaatctcg tttcaaatag aaatcttgcg tgaatgttca tgaagaacgc aacgcttctt 2967721 tgcactttat cctccagaag aacaagcttt tcttccctcg tctcggcctg ctggacagtc 2967781 gcgtccgcca ctatcatctc tgcaaacgtt gaagctgttt ctgcaacgtt catggcgtag 2967841 gaacggttta acggcctgac gttgagcatt gcttcctgat ggaacgcgtg cccgagttca 2967901 tgcgcaaggg tagagacatt tgaggcgctt cccgaaaatg tcatgaaaat ccgggattcc 2967961 ccgctgtccg gaaaactggt gcaaaagccg ccgactcttt ttccgctcct gtcttccgcc 2968021 tcaatccagc cgtcccgaaa cgctttttca gtgaatgagg acagcttttt gccaaacgtt 2968081 gaaaactggc tggtaatgat atttgcggct tcatcatacg aatagacctt tccgtcagaa 2968141 ccgatcggtg cctcgacatc gtaccagctg agtttttcaa ggccgagcat ggatgctttc 2968201 cggttcaaaa actgaacgaa cggcttcttg ttttcagtga tgacctgcca catcgtatca 2968261 agtgtttctt ttttcatcct gttaatttgc agcggttcct tcaggacatt ctcccagccg 2968321 cgcgctttat aggtttcaag ccggaatccc gccaaatgat tcagcgtgct gctgaaaata 2968381 tcttgcttgc tctcccaagc ttggcggaaa cgttcatata ctgtttttct gacagtacgg 2968441 tcttgatgat ccatcatatt ctccgcctga ccgacagaca attgcttgtt ttcaccgttt 2968501 tcctcatacg ggatcgtcat tttcccgaca accatattgt ataagtcact ccaagcgtga 2968561 tatccgtcca ccgcaaggtt tccgatcagt ttttccttac cggggctaag cttttcggca 2968621 accctctgtc ttctttcatt taatatgtaa gaaacatcgc gcaatcccgg ttttgttaac 2968681 aattcattcc acacgtcttg attaatgtcc acaagtttat gatctaatgt aacgagcgac 2968741 gattgaaaat ctgcggaaag ccgattcatg aggcctgatg ctctatagcc ttttgatcat 2968801 tgatattctg ggcctggagg caagcaacaa aagcgccggc ctgctgaagc ttgacggatg 2968861 tctgttcgaa taaatcaagc aacgcggtca gcccttcagc ctcttcaggc gattcaggca 2968921 cctgaaacgc atcagtcctg tcttgaaatg cacgcagact ttgtgacagc ttctcaatat 2968981 aacctttgaa ttcttccgat tggctcccgc ccttaaaaaa tgaatcaaga tcccatcttt 2969041 ggcctacccc ttgcagcgcc atatcacaaa acccctttcc ttctttcgtt ctattataga 2969101 acaattctga attattgtat aaaaatttct attacaggcg tcatttcgtg ttcaggatag 2969161 tacaatagct gtagcagttt aataggaggg ttaggatgaa taaaaaaata gccatcgtga 2969221 caggagcgtc cagcggcttc ggtctgctgg cagctgtaaa gcttgcccga tcatttttcg 2969281 tgatagccac atcaagacag cctgaaaaag cggaacagct tcgagaattg gctgcagcac 2969341 acaatgtgtc tgattctatt cacattacag ctctcgatgt caccgatgaa caatctatag 2969401 tctcattcgg aaaagctgtt agtgcttacg ccccgatcga tttactcgtt aacaacgccg 2969461 gaacggctta tggaggattt atcgaggatg tgccgatgga acatttcaga caacaatttg 2969521 aaacgaatgt cttcggtgtg atccatgtga caaaaaccgt gctgccttac ataagaaagc 2969581 atggcggcgc aaagattata aacgtgagca gcatcagcgg actgacagga ttcccagcgc 2969641 tgtcgccata tgtttcttcc aagcatgcat tggaaggttt ttctgaaagc ctgcgtatcg 2969701 agctgcttcc gttcggtatc gaaaccgctt tgatcgagcc gggctcatac aagacatcga 2969761 tctggtcaac gtcattatca aattttatgt cggtgcctgc tgacgattca gcctatcatc 2969821 aatactataa aaagatcctt tcctatgttc aaaaaaacgg agaagaaagc ggagatcccc 2969881 aagaggttgc cgacctcatt tatcaattgg caacaaaaca gcacataaag aatttgcgat 2969941 acccgatcgg aaagggcatc aagctcaccc tgctgttccg atcgcttttt ccttggtctg 2970001 cgtgggagtc tatcctgaag aaaaagctat tcagctgatc taaattataa ttattataat 2970061 ttagtattga tttttattta gtatatgata taattaagtc aacagatcac aaggaggacg 2970121 ttatcttatg aaaactgaaa acgcaaaaac aaatcaaaca ttagttgaga attcactgaa 2970181 cacacaatta tcaaactggt ttcttttata ctctaagctc caccgtttcc attggtatgt 2970241 gaaagggcct catttcttta cattgcacga gaaatttgaa gaactttatg accatgcggc 2970301 tgaaacagtg gataccatcg ctgagcgcct gctggcgatt ggcggacagc ctgttgccac 2970361 agtgaaagaa tacactgagc atgcatctat cacagacggc ggaaacgaaa catcagcatc 2970421 agaaatggta caagcattgg taaacgacta caaacaaatc agcagcgaat ctaaattcgt 2970481 gatcggcctg gctgaagaaa atcaagacaa tgcgacagcg gacttgtttg tcggattaat 2970541 tgaagaagtt gaaaaacaag tgtggatgct ttcctcttat ttagggtaac aaaaaagctg 2970601 aaccttaatc gggttcagct ttttgttttt tcttagcttg aactgctttc tgtctgcttg 2970661 gtcagtgttg cgttcaacgt tttcgttttt ccctttcgca gcacttggat tgttgtttta 2970721 tctccgactt ttaagtcttt gtaaaggatc tgacggatat ccgcactgct ttccacgtct 2970781 ttaccgttta gtttgacaat gacatcctca gatttaatac ctgctttttc tgccggcgaa 2970841 tttgcttgaa cttcttttac ataaacacct ttgcccaatt gatctccaaa caggccgagc 2970901 gtattttcct gataggtttc aggaacttgt gacatgtcaa tcatctgcac gcctaaaaac 2970961 ggacggtcca ccttcccgtt ttgcagcagc tggtcaacaa tcggctcgac atcattgctt 2971021 gggatcgcaa atccaagtga ttccacgccg ctttcgctca ccttcaagct gttgatgccg 2971081 atgacctggc cgcttgcatt gattaatggg cctccgctgt tccccggatt gatcgctgca 2971141 tcggtttgca gcacgttcat ttccaccgtc ccctgtgttg tatccacatc aattgtccgg 2971201 ttcagtccgc taatgatacc ttgtgtcact gtaccggaaa actgctgtcc gagcgggtta 2971261 ccgatagcga ttaccttttc gccagtgcgc agctgtgaag agtcaccaaa gctcgccact 2971321 ttttttacat tcttgccgct gatttccaaa actgccaaat cagtaatggt atcgctgccg 2971381 acaagcttgg cagtttccgt ttctccgttg tatagcgtaa cagtcagctt gttcgcgcct 2971441 tcaacgacat ggttgtttgt aatgatatac gctttatcgc tgtctttttt gaaaataaca 2971501 cctgacccgg ttccgctttc actttctgag ctggagcctc ctcccgtgcc gaatgtgtta 2971561 ttttgagagg tttggatatt tgagattccg acaatcgtag gctctaaatc ctctaccata 2971621 tcagcgatgt ttgatgcgtt cgttatcggc gccgttgtaa aattatcaga ctgcacctgt 2971681 ttatttgcgg aagcggtttc ggtcgcctga ttttggtctg acggcagata aggcgcgatg 2971741 ccaagcatga ggcccccgcc gataataccg cctaaaatcg ggctcagcca tgcggctctc 2971801 cgtttctttt cttttttcac agccgtttct tgcttttcca tttctaaagc agaagccgtt 2971861 tcctgccgtc ccgcttcata cgacacaggc gcgtcaagca attcttgttc agaatgtcca 2971921 atcagcttct ggttttctgt attctgctgt tctgtatgtg aaggttcagt ttgatgttga 2971981 tcgttttggc catcacgtcg ataatccatg ttcttacact cctttaacgg ttattcattt 2972041 atcgttacat attcatcgca tgtacaagtt caattgtccc aataatgagg agaaaagcaa 2972101 agcaccaaaa tagaatatgt ttgatcatcc tacatcttcc tcgctctttt tctcttcctt 2972161 tcttccctta accatatcat aaacaaacat tgtgggataa aaatgaaaag aatatgtgaa 2972221 attatgaaaa ttgcctgccg tatgttaaaa ctagtttata atgacgttga aaggatgtga 2972281 agagccttgt catacaccat ttatctagtt gaagatgagg ataacctgaa tgaactgctg 2972341 acgaagtatt tagagaatga gggctggaac attacatctt ttacgaaagg tgaagacgcc 2972401 agaaagaaaa tgacaccgtc tccccaccta tggattctcg atatcatgct gccggatacc 2972461 gacggctata cattaataaa agaaatcaag gcgaaagatc ctgacgtgcc ggtcattttt 2972521 atttccgccc gagatgcgga tattgacaga gtgcttggct tagagcttgg cagcaatgac 2972581 tacatttcaa agccgttttt gccgcgggag ctgattatcc gtgtgcaaaa gctgctgcag 2972641 ctcgtatata aggaagctcc tcctgtccaa aaaaatgaaa ttgccgtctc ctcgtatcgg 2972701 gtcgctgaag acgcccgcga ggtctatgac gaaaacggga atatcatcaa tttgacgtca 2972761 aaggaatttg atctgctgct attatttatc catcataaag ggcatccata ctctcgtgag 2972821 gatatcctcc taaaagtgtg gggacatgac tacttcggaa cagaccgggt cgttgatgat 2972881 ctcgtccgga gactgcgcag aaagatgcct gaattgaagg tggagacgat ttacggtttc 2972941 ggctacagga tgatgtcatc atgaaaaaca agccgctcgc gtttcagata tgggttgtca 2973001 tatccggcat cctgttagcg atatcgattt tactgcttgt gttattttca aacacgctgc 2973061 gagatttttt cactaatgaa acgtatacga cgattgaaaa tgagcagcat gttctgacag 2973121 agtaccgcct gccaggttcg attgaaaggc gctattacag cgaggaagcg acggcgccga 2973181 caactgtccg ctccgtacag cacgtgctcc ttcctgaaaa tgaagaggct tcttcagaca 2973241 aggatttaag cattctgtca tcttcattta tccacaaggt gtacaagctg gctgataagc 2973301 aggaagctaa aaagaaacgt tacagcgccg acgtcaatgg agagaaagtg ttttttgtca 2973361 ttaaaaaggg actttccgtc aatggacaat cagcgatgat gctctcttac gcgcttgatt 2973421 cttatcggga cgatttggcc tataccttgt tcaaacagct tctgtttatt atagctgtcg 2973481 tcattttatt aagctggatt ccggctattt ggcttgcaaa gtatttatca aggcctcttg 2973541 tatcatttga aaaacacgtc aaacggattt ctgaacagga ttgggatgac ccagtaaaag 2973601 tggaccggaa agatgaaatc ggcaaattgg gccataccat cgaagagatg cgccaaaagc 2973661 ttgtgcaaaa ggatgaaaca gaaagaactc tattgcaaaa tatctctcat gatttaaaaa 2973721 cgccggtcat ggtcatcaga ggctatacac aatcaattaa agacgggatt tttcctaaag 2973781 gagaccttga aaacactgta gatgttattg aatgcgaagc tcttaagctg gagaaaaaaa 2973841 taaaggattt attatattta acgaagctgg attatttagc gaagcaaaaa gtgcagcacg 2973901 acatgttcag tattgtggaa gtgacagaag aagtcatcga acgattgaag tgggcgcgga 2973961 aagaactatc gtgggaaatt gatgtagaag aggatatttt gatgccgggc gatccggagc 2974021 aatggaacaa actcctcgaa aacattttgg aaaatcaaat ccgctatgct gagacaaaaa 2974081 tagaaatcag catgaaacaa gatgatcgaa atatcgtgat caccattaaa aatgacggtc 2974141 cgcatattga agatgagatg ctctccagcc tctatgagcc ttttaataaa gggaagaaag 2974201 gcgaattcgg cattggtcta agcatcgtaa aacgaatttt aactcttcat aaggcatcta 2974261 tctcaattga aaatgacaaa acgggtgtaa cataccgcat agcagtgcca aaatagactg 2974321 tagatgtttt gcagtctatt tttttatgtg aaagaatagc cgttaaaatc tctgtaattt 2974381 gttttgagcg gctgtttgca ttgatgaacc cattttttct ctgacaaggt ctgcttcgga 2974441 tatttgactt tctccacttt gattcctctg tttcgcaagc ggctgatcat ttcgtccaat 2974501 tctctcattc tagattcacc ctttcgcttg agctttgacc attcggtcat ctcaatttat 2974561 aatataaata atacatgata aaaaaacaag ttacaataag gttaatttta taacagacgg 2974621 tgtgactata tggtcatatc ctagcaggcc tccgggctcc gaaagggtgg aaccattgaa 2974681 ggaaaaagaa aaactgatta ttgaaacagc cttaaaacta tttgcccaaa aaggatacaa 2974741 ctcaacatca gtccaggaaa tcgcaaaaga atgcaaaata tctaaaggcg ctttttatat 2974801 ttattttcct tcgaaagaag cgcttcttct ctctatgctg aactactatt atgataaaac 2974861 gtttacccga attttaaata ttaaaacgaa gggcgacagc cccagaacgg cttaccgtaa 2974921 acagctgacc gtcctctatg aaaacattct tgaacacaaa gattttatca gcatgcagtt 2974981 gaaggagggt tctctgcctt acacagaaga agtggagcaa tgcgcaaaaa aaatccgcca 2975041 gtcctcactt caatttcata tcgacagcct gctgaacatc tatggaaaaa aagcggaacc 2975101 gtacactgct gagctttgtt ttttaataga gggcatcagc cagatttacc tggaatgcat 2975161 gattttgctc gggtacactg tgaagccgtc tcaattagct gatatcatta tgaatcgaat 2975221 tgatgatatg gtaaaaggca tgtctgaacg aaacgataag cctttcatca cattggaaga 2975281 ggcgagctct ttattcggac ctcttacgca cggacggcct gacccgctga ctgaatcaat 2975341 tgtgaaaagc ctacgtgaca aaattaacag cttaaacaca aactcctctc ttgaattatc 2975401 ggagagcttg gacatacttg aagcagaaat gaagaaaaaa acaccgaagc tggcgatcat 2975461 aaaaggaatg attcataatc tgacggagtc tgaagctctc gccaaagatg cggaacagct 2975521 taaatattta ttaaaacagc aacatattta gaagaacggc tgcttaaaaa gcagccgttc 2975581 ttcctattac gcctttggtt ttaccatgtc ttccggctta accatttcgt taaattgctc 2975641 ctctgtcagc aattcaagct tcaaagctgc ttctttgagc gtcaatccct ctttatgggc 2975701 aagcttggcg attttcgccg cgttttcata accgatatgc gggttcagcg ccgtaacaag 2975761 cattaatgaa tttgacaggt tttcctgaat ggtttcttta ttaggctcaa taccgacagc 2975821 acatttatca tggaatgaat tcatgccgtc actgagcagc tgcacagatt gcaggaagtt 2975881 gtaaataata acaggcttaa acacgttcag ttcaaagttc ccctgactcg ccgcaaagcc 2975941 gattgtcgca tcgttcccca tgatttgcgc tgcgatcatt gttaacgctt cgctttgtgt 2976001 cggattgact ttaccaggca taatagagct tcccggctca ttttcaggaa tgacgatctc 2976061 cccgatgccg cagcggggtc cgcttgcgag ccatctgaca tcgttcgcga ttttcattaa 2976121 gtcagccgca agcgctttta atgcgccatg cgcataagtg atttcgtcat ggcttgtcag 2976181 cgcgtggaat ttattcggcg agctgctgaa cgtttggccg gtcagcttag tgatctcttc 2976241 tgagacaagc tctccaaact ctgggtgggc gttgataccc gttccgacag ccgttccacc 2976301 aattgcaagc gcacgcattt tatctgtcgc ttccaaaatc atttccttcg aacggtccag 2976361 catgtgaacc catccgctga tttcctgtcc gagggtcagt ggcgtagcat cctgaagatg 2976421 cgtgcgtccg attttgacaa tatcattgta tgcttttgct ttttcatcca gtgtattgcg 2976481 aagctgatca agcgccggca caagctgctc gtaaacagcc aaaacagcgg caacatgcat 2976541 cgcagtcggg aatgtgtcgt ttgagctttg gcttcggttc acgtcatcat ttggatgaat 2976601 cgtttgatca gagttcttct cttttaataa agcagtcgca cggttggcta ccacttcgtt 2976661 catgttcata ttgctttgtg tgccgcttcc ggtctgccat acgacaagcg ggaagttgtc 2976721 atcgtacttg cctttgagca catcatcaca aaccgctgca atcgcttctg ctttttcagc 2976781 gtccagattg ccgaggcgtt tattagctag agcagtgctt cgttttaaaa ttgcaaacgc 2976841 cttcacaaca cgcatcggca ttttttcaga accgatctta aagttctcct tgcttcgctg 2976901 tgtttgggcg ccccaaaatt tatcagcagg aacttttact tctcccatgg tgtctcgttc 2976961 aattctgtat tccatttatg tatccctcca taacggttgc ttcaatagat cataattcgc 2977021 caatgacaca aaaaatcctt tttatttttc gatcttggca gattttaatt ttaattcaag 2977081 atatacgcgg gaatcctttg aatatttgta ttttggattt gtcctgccgt actcctttga 2977141 tgtataagag acatcataat gctgttcaaa tgatctaatg agctgttcaa tttcttcttg 2977201 ttttccagct agccttacct gtgccacttc gtatcctccg ctttcataaa aaaacttact 2977261 ccatgaaata ctctaacaca gtatatcatt tttttaacag gaaaagataa cctctactaa 2977321 ggttttggat aagaggtgac ctcattggaa caaacagagt ttaaggaata tatacacgat 2977381 aatttagcat tggtgctgcc aaaattaaaa gaaaacgatg atctggtgaa aaacaaaaaa 2977441 atgcttgcga acggactggt tttttactat ctctatttca gtgaaatgac tgatgagaat 2977501 aaggtgtcag aagccattaa aactttgatt aaagatgagg agaccttaac gcttgaccag 2977561 gtcaaaaaac gccttgacca gcttgacgca agacctgttg aaactgcaaa aaaaacgatt 2977621 gaatcgattc tcaacggcaa ttgtgctgtg tttatcaacg gattggataa agcctatatt 2977681 ctgaccacag gaaagaaaaa aacaagaagc ctgacagagc cgacaactga aaaagtggtt 2977741 cgcggcccaa aagtagcgtt tgtagaggat attgatacaa atctcgctct gatcagacaa 2977801 agaacctctc atccgaaatt gatcaccaaa aaaatcatga tcggcgaaaa caagctgaag 2977861 cctgcagcca ttatgtacat tgaaggcaaa gcaaaaaagt ccgtcataaa agaagtgaag 2977921 gcgcggctta aaaatatcca gctggaagat atccaggaca gcggaacgct cgaggagctc 2977981 attgaagata ataaatattc accatttccg cagatacaaa atacggaaag acctgacaaa 2978041 gtatcttcag ccctgtttaa cggccgtgtg gcaattttgg tcgacagttc accatttgtg 2978101 ctgctggtgc cggtttctct cggcatcctg atgcaatccc cggatgacta ctatgaacgc 2978161 tggatttcag catctcttat ccggtcgctg cgctttgctt ctatctttat caccttgttt 2978221 ttgtcatcga tttatataac acttgtttcc ttccatcagg ggctgctgcc gaccgcactc 2978281 gccgtcacga tttcggcgaa cagggaaaac gtgccgttcc ctccgatatt tgaagccctg 2978341 ctgatggaag tcaccatcga gctgctaagg gaagccggac tgcgactccc caatccgctc 2978401 ggacagacga tcggcctcgt tgggggcgta gtcatcggac aggctgctgt agaagcgaat 2978461 ctcgtcagtt cgattttggt cattgtcgtc agtgtcattg ccctggcatc ctttaccgtt 2978521 cctcaatacg gaatgggtct gtctttccgg gtgctgcgtt ttatttcgat gttttccgcc 2978581 gctattttag ggctatacgg cattatttta tttatgcttg tcgtttatac gcacttaacg 2978641 agacaaacga gctttgggtc tccgtatttt tcgccaaacg gattctttag cctgaaaaat 2978701 acggatgact ccattatccg tctcccaatt aaaaacaaac caaaagaggt gaataatcca 2978761 aatgagccaa aaacagactc cactgaaact taataccttt caaggtattt ctattgttgc 2978821 aaatacaatg cttggggccg gacttttaac attgccgcga gcgctgacca ctaaggctaa 2978881 tacgcctgac ggctggatca cgctgatatt agaaggtttc atttttattt tcttcattta 2978941 tttaaacacg ctcattcaga aaaaacatca atacccttca ctctttgaat atttgaagga 2979001 agggcttggg aaatggatcg gcagcatcat cggccttttg atctgcggct atttcctcgg 2979061 cgtagccagc ttcgagacac gggcaatggc tgaaatggtg aagtttttcc tgctggagag 2979121 aaccccaatt caagtcatta ttttaacgtt tatttgctgc ggcatttatt taatggttgg 2979181 gggcttaagc gatgtgtcgc ggctgtttcc cttttattta acggtaacca ttattatttt 2979241 gctgattgtg ttcgggatca gttttaaaat ttttgatatc aataatttgc gtcctgtttt 2979301 aggcgaaggc cttggaccca ttgcaaactc ccttaccgtc gtttccatct cttttttagg 2979361 aatggaagtg atgctgtttc ttcctgaaca tatgaagaaa aagaaataca cgttcagata 2979421 tgcgtctcta ggatttctga ttccgattat cttatatatc cttacgtata ttatcgttgt 2979481 cggagctttg accgctcccg aggtgaaaac gctgatttgg ccgactattt ctctctttca 2979541 gtcctttgag cttaaaggca tatttattga acggtttgaa tcctttttac tggtggtctg 2979601 gattatccag tttttcacca catttgtcat ttacggatac tttgccgcta acgggctaaa 2979661 gaagacattt ggattatcga ctaaaacaag catggtgatt atcggcataa cggtctttta 2979721 tttttctctc tggccggatg acgccaatca agtcatgatg tatagcgatt atcttggcta 2979781 tatttttgtc tccctgtttc tgcttccgtt cattctcttt ttcattgtag ctctcaagag 2979841 gaggattaca acaaaatgaa aatccggatt ttatgtatgt ttatatgcac cctattgctg 2979901 tccggatgct gggacagtga gaatatcgag gaattaagct tagtgatcgg aatagggcta 2979961 gacaagcctg acgatgaaaa tttagagctg acacagcaaa ttctcgtgcc gaaaataatc 2980021 agcgccaagg agggctcttc atctgatccg acacagcttt ctatcacaaa gggtaaaact 2980081 gtccatcaaa tgatgagaac ctctgcatta aagcataagc ctacgttttc acagcatttg 2980141 cgtctcattc tgctttccaa aagcgtgatt gcggatcaaa ttggaatgga cgccattatt 2980201 aaccagtttg tcagagacaa cggaacaagg aggagttcct acgtctttat caccaacggc 2980261 cgaactaagg atatatttaa catgaatgat gaaggcgaac ccgcatccaa cgtgatatat 2980321 gatctgacag agaataataa ggtgacgatc agaacgatgg agccagttac attgggggag 2980381 atctcagaac acttaacctc tgacgattca ttcctcatcc ctcatgtcgg taaggaaaac 2980441 ggcaagctcg cgataaacgg agcctctatc ataaaaaata aattatggca ccgggacctc 2980501 accccgattg aggttcaaaa tatcagctta ttttcaggca ctgtcgaggg aggcgtcatt 2980561 gacttgaagc gcgatggcca tctcttttct tatgaagtat attcaagcaa tcggaagatc 2980621 aagacggcat acaaggacgg aaagttcaaa ttcaccgtta cccgcaatat tgaaggtcgt 2980681 ctatctgagg actggaatcc caatgaagac tcgtttaagg attcatatat taaaagtatt 2980741 gaaaagacag tcgaaaaacg agtacacgaa acagtaacgt catttattac agagaagctg 2980801 cagaaagaga tcaaagcgga cgtaaccggg ctgggaaacg aggtcagaat tcattatcct 2980861 caaaagtgga aaaagatttc aagaaaatgg gatgatgatt atttcagcaa tgcggaaata 2980921 gactaccggg tcaatgtgat tgtcagagac ttcggaacga aaggcgcaaa caaatagcag 2980981 ccgcctaatt cacgagatga tttcggtgtg cgtacaccgc cgcctgcgtc cggtcactga 2981041 catccagctt tgataaaata ttcgtaatat gtgttttgac tgttttaatc gtaataaaca 2981101 gttcctcgcc tatttctttg tttgtctttc cttctgcgat caggcagagt atttcgagct 2981161 cccgttttgt aagcgattca tgcgggagcg cgttttcacc tgagtggcgc agcctggata 2981221 atacttttcc cgccactttt gactccagct tcggctctcc cttgcttgcg gcgcggatgg 2981281 catcggcgat ttctgccgct tttgaggttt tcaacagata gctgagcgcg ccagcttcaa 2981341 taaccgggta cactttgtca tcatcaatga agctagtgag cacaataatt ttcgggtcgg 2981401 aaagctcccg gcaaatttgc tttgtagctt caatgccatc catgccctcc atgacaaggt 2981461 ccattaaaat gacatcaggc gacagttcca cagcaagccg aacaccttcg ctgccgtccg 2981521 atgcttcgcc gatgacttca atatcgggct gcgcctccaa aaaagccgcg agccccattc 2981581 tgaccatttc atgatcatca atcaataata ctcgaatcac gttcgttctc tcctttttct 2981641 tccggaaaaa tcgggacctt cacttcgatt tgagtgcctt ttccttctac tgaaatcact 2981701 tcggcgacac cgccgatttc acttgcacgt tctttcatag aattcaagcc gtatgaggag 2981761 gctttcacct ggtccatttt aaagcctttt ccattatcaa tcaccttcag acggagctgg 2981821 ctgttcttta tgcccagaat cacggttact tttgacgctt ttgaatgtct aaatacgttt 2981881 gaaagggcct cctgcacgat tctgaacaag tggtcttcaa cacccttgga tatcgctgtg 2981941 tcctgtatat cccactcaat atcaatcggc tgcttttttc ggaactcgtc caaaagctcc 2982001 gtaaggccct ccttcagccc ttttccttca agggtaacag gccgtaaatg gagcagcagc 2982061 gccctcatct cattttgggc ttcgcctgcc atatgctcga ccatcctgat ccgcttgact 2982121 gttttgtcat cagcatcctt gacatgttcc agcacggctg atgtcatcat cgatatggca 2982181 aagagctgct ggctgaccgc atcatgaaga tctctggcca atcgctggcg ttcttctgag 2982241 ataaccgact tcttcatttg agcctgccat tccgcacgtt cattggaaag tttctggagg 2982301 gatgcgactt gaagctccac gcgcttcgcc atttcgttca gctgatcagc agccaggccg 2982361 atttcatcat caccgagcgg cggtatccga taagcgaaat tgccgttttc aaaggttaaa 2982421 atggattcaa ttaatgtatc aatccttgtc ttcaaccggt tgccgtacat ataccctgag 2982481 gcgaaaccga cggtcacgct gatcagaagc aaaatcagga taaacggaat tccgaaccag 2982541 cttgatgaca gcaaaacaag cggatcgagc cgatagtaaa acatcataaa ggaaatcagg 2982601 caaacaaaaa ggagcaggct gattcccgtt gtcatgcgga tggcgcgcca ttggaggctg 2982661 gcaagcattt tttttctcat acgtacttca catccacatc accgataaat aaggaaacgg 2982721 acacttttac ccggcgcttt gactcgctaa aatcagttga cgcggcatat accttcgtgc 2982781 ttaatccgct tttcttcgag ccgatcagat taatgtctcc tataaaaaca gccgagctga 2982841 cagccacttc aaggtccgat ggtacataaa tatcaacgtt accaatgact ccgctaatga 2982901 cgattgtact ttctccctcg ggaatcatcg ctttagataa atcgattttg atatcaccga 2982961 taaaaccaga gacatttaaa tcgttcaggt caaacggctg cttcatcatt tgcagctcac 2983021 cgataaaaaa gctgcgcatg tcgggatgtt ttacatcttt tggcggctca tgatgttctt 2983081 ttttattgag attgacctgt ttctcattcg gttcaaatat cggcttccct ttgataagcc 2983141 tgtagccggc gtaaatcaga aatgcggcaa acgcatagcc gaataaatta aaggtgatgc 2983201 tgaagaggtt tttcaaaaat agaaacgcgg caaagatata catgacggag ccaagccaat 2983261 cacgggaata ttttttaagg aaatagccgg caatcagaaa aaagagcggc caaaacagca 2983321 gatcgcctat tccgataatt tgcaaaaaca tactgatgcc gaataaagca atgatcaatc 2983381 cgagaagctg tttttttgtc attcctggtg tccgcctcct ttcttctgcc tagtgctacc 2983441 gtatcgctag atccccgctg tccgttttga tgtcgattgg atgccggccg cttccttgcg 2983501 tgcctgtgat gtgatgctgt tctttatgtc ctttatcagc aaatgaatac ggcgaactga 2983561 cgtcaccgct tgctgataaa gcattgactg caaagctgcc attttgggga aggcttacat 2983621 tagcatcacc gcttgtcagc gtgacagata cgggaccggt tacctttttc aatacagcat 2983681 taaaatctcc tgaagtcatt ttcacatcaa gagagcctga tacatgaacc agatttgcgt 2983741 cccctgaagc taaatcaatg ccggctgttt tggagacggt atttgaaatg gaaacatccc 2983801 ccgatgatgc cttcactttc agatcttgaa tgcggacgtc cgtcacgctc gtatttccgc 2983861 tcgcagatac tgcgttcagc ccggaaagcg caagatggtc attcccggcc acagacacgt 2983921 caccgcttga ggttcgtact gccagatcac ctttataatc atacggaagc ctgacgataa 2983981 gagttgaacg gttaaatcca ttcaaaaatt gaaattcttt ttcctttacg gtcagctcca 2984041 gttttctttt gttttcagta acaaataact ttcctgagtc tcctgaaatg cctgccgata 2984101 tgtcacttcg ttcttccgct ataatccgga catccttgct atccgactca atgaccatgc 2984161 tgtcaatgtc ccgcggcgat gcgctggctg aatcagcttc tgtgccattt atgaaaccta 2984221 ggcctgcagc aaacacatct tttacgacga cggcgaaaaa aaccagaata ccggcagtga 2984281 tcaacagttt gccaagcatt tttttcattc ggtttcatcc ttctcattca ttctattata 2984341 aaggaaaagc ttgcgaattg atacgtgcgg aagggaagga cttgaccgca aatccttccc 2984401 cgttccgctt attcatttgc cgcttttgtc tggtctgatt tttgcagtga aagtgtccgc 2984461 attttttcaa tctccgcttc cacatcgtct gcgaattctt tacgtgtaag ttctgtgccg 2984521 gcttccgctg actttgaata attcgcgcgg atttccattt cttcaatacg attttcaata 2984581 cgtaaaaatt cacgatacgc gctttcactg tcaattttgt caaatgtcgt attcatatgc 2984641 tctttagctt tcgccgcatt tgcccgcgca atcagcgcct gttttttatc ctttacgtcc 2984701 tgaagctttg tttcaagtgc agccagctgc tctttcagat cagccagctg actgtttgcc 2984761 tgttcatagg aagctttatg ctcagccgcc ttcccttcta aatacttcat ttcagtcagc 2984821 gcctttttcg ccagttcttc ttcacctgcg tcaaatgcga gctgtgcctg atttttccgt 2984881 ttgccagcca cttcagcggc ttcttcatat tttttcttaa attgataggc aatcgtgtgc 2984941 tgtttcacaa ttgtttgctt tgcttttgcg atgtcgcttt ccatatcgcg tacatattga 2985001 ttcagcatca cctttggatt ctccatttta tcaagtcctt catgaactga cgcaacaaac 2985061 atgtctctga ttctttttaa taccatacct gattcctcct aatatattga tattattttt 2985121 tcttcaaaaa ttcttcccat tcgtcatcaa agtgagattg gtaggcagca gaagccggtt 2985181 caggatcaaa agatgataca ccgttatcag ctgatccgtt tttcatcagc ttccagccgt 2985241 aatacaccat agcggccgcc aatgcgattc cgacgacaaa cggaagtgag cagatgagca 2985301 taatggctcc gataccgccc acgatgattc ccgtgatggt ttttcccgcg gcaaaccttt 2985361 tgattcctgc gtatgtcatc aagctcccga tggcgagcgg gatgataaag ccgaagcttc 2985421 ctcctccaaa aaagacggag atcccaaata caattaataa gaatccgcct attgttttct 2985481 tgtttatttt catgcagatc ctcctttcgt tttccttgtc ttcatcttat acaagttgga 2985541 agatatgcaa aacgaatcag agattgattt ttatataaga ccggagtcgt atctcgcacc 2985601 ggacccattg gcacaaaaaa acgccatgca cgaggcatgg cgttttaaaa ccctttacag 2985661 atgaacactt gcttcccttt ctttaattag gtcggacctt tctgctttgg ccaattttgt 2985721 aaacagcaag attccgatac ccgcaataat ttcgacaatc ccaccgacag cgatcacttt 2985781 acctgagccg aaagcattag cggcataccc gcaaatgaca gctccggcag ggatcgaaat 2985841 atttgagatc atatgtataa cggcgtaaac ctgcggctga tcctcactat ccacagacgt 2985901 ctggataatc gtgtactcag gaacattaac agcactgact gcggcaccaa aggtaaaagc 2985961 agcgaaaaag acgagcggca aaaaggtatt catcccggta ataaagaaag caaatccttc 2986021 aataatgccg gcagtgacga ataacaagcc gtacctgttt accttgactt tcgccagcac 2986081 aaaccctaat aaaaacgcgc ccgcggcggt ggtggccttt aaaagcgagt atacgatcgg 2986141 ctggccgttt aaatcttccg caacgtatac ggcagagagc gcttcccatg gggcagccgc 2986201 gaaattcata aagatacagt aaatggcgag cggatataaa atctggtgtt ttctgacgag 2986261 cctaaagccg cgtttcagtc ttccgatata tgtgcctctc tgtgtaacaa ccgcagactc 2986321 tgattgagat tcaaccgcag tgtacttaat aaaaagaacg agaaaacctg acaccaaata 2986381 gagcacaagt gcgataagca tggtataaga aggactaata aatgtaagaa aagcgccgca 2986441 taatgtgaca gccccaagcc ggacaatttg agcggaggat tgcagcacag cgtttgcttt 2986501 ttgaatgccc tgttcattga cgatttgagg aatcaaagcg atagaggcgg gattgtaggc 2986561 agctccagta gctgaatgca caatcataag cgtcatgaca aaccacagcg gagagaagcc 2986621 cgcaaaatga catagaggga taatcaaaac aatcgccgcc cttgtcagat ctgaaaagta 2986681 catccaaaat ttcagcgtgg tctgtttcat aaaaggcccc gtcacaggcg ccagaacggc 2986741 ttccggcaaa aacgtgacag caatcaataa agcagtgccg atcgcacctt tgccgtcata 2986801 aattaaaaac cataatattg aattaaatgc gaacatatcg ccggatatct tgactattct 2986861 tgagaaaaac agataattga aatttctctt ccagatgcta tcactttcaa ttaaattcac 2986921 catccatcag agccccccgt tgcctatttt ttacatctat ttattacaat atctcatttt 2986981 tccatttttc agtcaataat tcataaggtt cattttttgt cgtaaaatgg gaaattgaca 2987041 gagtgaaaaa caaaaaaagc cggcatgtat ttgaacacgc cggctttcct tttcactttt 2987101 tatgattcgc tgctgtttcg gtcccgaaac acaatggcac ttctttcata ttctacatcg 2987161 ccaataccgc ttcttgcatt cacaacccgg gcggcggcaa agaaataatc ggacagacga 2987221 ttgagataac gcagcactgt ttcatgaatc tcctccgatt tcatcagcgc caccactctt 2987281 cgttctgccc gccttgtaat ggtgcgtgcg atatggagaa gcgaagcaca ctttgatccg 2987341 cctggaagaa taaatttctt cagttccggc gcttctgctg tataggcatc aatgcgcgtt 2987401 tctaaaaagg aaacagattc ttccgttagt ttatagtctt ttctttctgt gacgattgcc 2987461 agatcgcctc cgcagtcaaa cagctcatgc tggatggtca gcagctcggc tgtcagatct 2987521 tcaaagccgg gctgcccgga aagctctgcc aaagcaagcc cgataaagct gttaagctcg 2987581 tcaatcgtgc cgtagctttc gacgcgtagg ctgtccttgt ccgttctgcc cccgactaag 2987641 cccgtttgtc ccttatcgcc tgtttttgta tatagtttca taccctgaat ctcctttaca 2987701 gacttattca aacaactcag cagcctcttt tatacattca gctgtccctt tctttatcaa 2987761 ttggttcagc cgctgttcta tgttttctga ttgctgagtt tgagtcgcgg cgatgagaat 2987821 atcacctgtg cctcctccgt ctcccagcac tttcgtccgt tctgcttcgg cagccataag 2987881 agctttgatg aagaattgat ctgccgcata gccgttaatc aaaatccaaa tcgaaaagcc 2987941 ggtctgaacg catatgaaaa cggataactc tccgtcttca tatgttcgat acacgaaacg 2988001 gtcaagtctt tctgaagaag ccatcgcaca cgtctcctgc agttgaaaac cgctttctga 2988061 aagacaggcc gtaagtcctt ctatcggatc tggctgatct ggcagccgtt tatggatcag 2988121 cgtcctgctc cacgaaaacc ctgcaccgat aggcgtggag gacaatgttc gaagcgggat 2988181 ttccgtttgc agaagaatgt catcacgccc cgcttggagc aatgcttcaa atgggataga 2988241 ctgccgcttc acgctatctt tttcaggctg aatcacaatc atcggtttag gtgagctttg 2988301 atgaaccaag gcggtgacat ctgtatcgta caccgccttt atgctttgtt ctgtaacagc 2988361 atattccggt ttttgcttag gcccggcggt accgtttttc ataaacatga gcccatcaca 2988421 gtacaggctt gcggtgttca gatcatgaaa aacgctgaca gctgccaatc cgctttctct 2988481 cgtcaggcgt ttgatcagat caagcaggtc tttttgataa gccagatcga gaaaattagt 2988541 cggctcgtcc aaaaataaaa tacgcggctg ctgcgccaaa gcttgtgcca aatacacccg 2988601 ctgctgttcc cctccgctta gttcgcgaat cggcttttgc gcaaaatcgg ccactcctgt 2988661 ttgctccatt gcttcctgta caatggcttc acccttttca gtctgctgtc tgaacagccc 2988721 cgtttggaat ggatatctgc caaaggctac agtttcttcg acagtaaagg tgaaggcttg 2988781 atccattttt tgcggcagga cagccatgat ttgcgccagt tccttcggtt tatagtccgc 2988841 cagcagtttt ccggccagat aaaccctgcc tttcttggcc ggcagcgtac ctgtcagcaa 2988901 gtgcaaaagc gtggtttttc cgcttccatt agggccgaga attccaagaa attctccctt 2988961 ctccactgtt aagctgacat tgttgattag gcggctgtcg ccgtatcctc ccgacagccc 2989021 ttctgccttc atcataagct tctccccccg cgatgctgcc gaattaaaat aagagcgaac 2989081 acaggcgctc ccgccaagga cgtaatgatc ccgatcggca gttcaatcgg ctcaatgatg 2989141 gttctggaaa gcagatcggc taaaacaaga aaccctgccc caagcaaggc ggacaacggc 2989201 agtaaatgcc gatggtccgt tccccacaaa agccttgtga tatgcggaat cacaaggccg 2989261 acaaagccaa tcgtacccga tactgccaca gcgcttcccg tcaaaagaga tccggctatt 2989321 aaaatcatca tcttcctctg ctgaacgctg actccaagaa gctttgcttt atcttctcca 2989381 tatgtcatca cgttcagttc ccttccgttt ataatcaata aaatggttcc caaaagaaaa 2989441 aacgggagaa acaaaataac atagctccag cccctcattg agacgctgcc aagcagccaa 2989501 tgcacaatcg gaagcaggtt gtctcctgtc aaggcgatga taagagaaat aaatgcgcct 2989561 aaaaaagagt tggtgatgac accggtcaaa atgagggtgg aaacagacat cgaagcatga 2989621 acgaggcggc tgaagaaaag gaccgccgcc atcgtggcca gtgccgcggc tacactcaaa 2989681 accgggagtg taaaccctcc gatgacagga aggtgcaaac ctaagaacag agtcacaaca 2989741 gctccgactg aagcaccgga tgacacacct agcgtatagg gatcagcaag cggatttttc 2989801 aacaatcctt gaaaagcggc ccctgcaata gaaagagccg cccccacaag ggcggccagc 2989861 acaactctcg gcagtctgat attcatcata atattagtgt acatcggatc atcagaaccg 2989921 atagagccgc cgaaaccttg atgccaaaag acacgaaaaa cagcgggaat aggaatatgc 2989981 aggctgccgc aagaaattcc taagatgatg ctcacggcta aaaatgagaa accaatgata 2990041 tatgcggcat aacgattatt ccttaaacgt atccgggtaa atgctttccg caagttcttc 2990101 gaccccttcg atcagacggg gaccggaacg tgtcacaaga tcagggtcca catcatatac 2990161 acgatgatgt ttcacagcat tgatttcgct ccagccatcg cgtttttcca cagctttcgc 2990221 tttcacaccg tccgttgtaa caattgcatc aggattgagt tttacgatcg cctcgtctgt 2990281 catttgcacc catcctgtct gatccgcagc tgcgttttta gcatggatga catttagcat 2990341 ttcattcata aacgtatctt ttccggttgt ataaatgtca ggatcaggag aaacctcgat 2990401 aaatacgctt ttctcctcgt cttttgaaat ggttttcgct ttttcttgaa tatcctttag 2990461 atctgatttc atgcttttca cgagctgatc ggcttttttc tccgccccgc cagcttctcc 2990521 gatcatttcg attgatttgt acacctcgga gaatgattgt gcatcattga cagtcagcac 2990581 tgtaatgccc gcgtccttca gctgtttgat ggcatccgct gatgctgaca tggaagactc 2990641 atgggccaga acgagatctg gttttagaga aatgactttt tcaacgttta cattcatatc 2990701 tccgactttc tcaacctttt tgacttcctt tggataggta tcgtttgtgg tgacaccgac 2990761 cactttgtca ccaaggccga gtgcgtatgt aatttctgtg ttgctcggca ttaatgaaac 2990821 aatctttttt ggctcttttt tgatggttac atcttggttt gacgcatcat caatggtgac 2990881 agggaacact tctgtttttt gttttgcctt tgaatccttc tgatccgcag gattgccgca 2990941 gcctgccagc ataacagcag ccaacagaag cgcagcccat atcccggctc gttttttcat 2991001 aatcttttcc tcctaaacga actaaaaaag catctctacg acggtaaaga tgctgtaaac 2991061 aacacaaaaa agcctattgt ttacacatca tctgtcctcg cagaattcgt gctgatcaaa 2991121 caggcaggta tcctggctct tggcgcttgg ccaattacag tggcgggacc gcaccggctt 2991181 ttaccggttt cccttttaag ccggctgttg ttcacggacc ggcacctatt tgacattcgt 2991241 atccgttttt cggagtaatt atactatatg actgacaggc ttgtatatgt gtcctgaatg 2991301 acttttcccc atattgtgta tggaagcaaa atcctcgtaa acactaaatt tgatcttgta 2991361 tacttaatac catcatctat caaaaggaat gattcttatg gatttacagc taaaagaaaa 2991421 actcgtctta atcaccggct cgacgtccgg tatcgggaaa gccgccgcaa aaagctttct 2991481 gcaagagggt gcggcagtca ttgtcaacgg acgcaaacag gagactgtcg atcgcaccat 2991541 tgaagagctt tctggctatg gaacagtgca cggtgctgct gccgatttgt caaaaacaga 2991601 tgaagcagcg gcttttatcg aaaaagtaaa tgaaatcggt gatatcgata tccttgtcaa 2991661 caaccttggt ttcttcgagg taaaagactt cgccgatgtg acagatgaag agtggaatca 2991721 atatttcgaa gtgaacgtga tgagcgccgt tcggacaagc cgtcacttcc ttccaaaaat 2991781 gcttgccaaa aacagcggcc gcattttaaa tattgcaagt gaagcaggcg tcaaaccgct 2991841 gccaacgatg attccatact caatgacaaa aacggcactg atcagccttt caagaggaat 2991901 ggctgaaatg acaaaaggca caaatgtgac ggtcaactca gtgctcccgg gacctacttg 2991961 gacagagggc gtggcctcct atatggaagg cgccgcacaa gcagccggac aggatacaga 2992021 tacatttatc aaagactatt tcaaggtcaa tgagccaacc tcacttattc agcgatacgc 2992081 gacagcagaa gaagtcgcca acacaatcgt attcctcgcg tctgacgccg catccgccat 2992141 taacggcacg gcacagcgtg tggaaggcgg cattatccgt tctctgtagt ataaaaaaac 2992201 gcatccgtgt ttcggatgcg ttttttttat acgtctccag caaatggtac cggctgatat 2992261 ccgcctgttt ccagttgtgc tgaaaacaac cctccagcgt gaggctgctc gtatctctct 2992321 ttttctgtca tttgttctgt tgccgttgta atgtaaaggg tttttaagtc tctgccgccg 2992381 aacgcgcagc acgtgacata tttagccggc acgctgattg aattgatttc ttttttctga 2992441 aacgggtcaa tgtgaacaac gcggctgccg ccaaacagcg ccacccacag catgccattt 2992501 tggtcaattg tcatgccgtc cggcaatccg tctgactgat caaaacgata gacaggttct 2992561 ggattcgaaa catctccgct ttgaggatca tagctgtaac gtacaatctc ctgggtcggc 2992621 gtgtcgatgt aatacatcaa attccgctcg cggtcccaat ccaaaccgtt tgaggtggag 2992681 acttgatcct tgattttgac aagactgccg tctagattca aacggtacag cgacgcctgt 2992741 ttttgctcgc cttccatgct cgtcgtcccc gcccaaagcc ttccgtacgg gtcacattta 2992801 gcatcattaa atctcaggct ctcatgcatg tccttcggct gtttaatttt ttccaagctg 2992861 tcatcccgaa gatgatacag gtaaaacccg tccttcatcg tcataatcag ttcatccttt 2992921 gaatatttcg caagcgccgt cacaaaggat ttgaatttga ttgatcggtt gattttttct 2992981 tcagggtcaa agatgtggag ctcgctcccc aggatatcaa cccaatataa gcggccgttc 2993041 tcttcatccc ataacgggcc ttcaccaatc actgcccgag tgtctgcttc caatactgca 2993101 tccatgtgtt acacctcttt agcttcagtc tatatattgt tattcccggc aaagaggtgt 2993161 ccaaaccact tgatgtttat tgttttttaa aaaggatggt aatgaccgtt ccaatgttcg 2993221 ttctgctgtt cacatggatc gttccgttat gcagatggac aagctccttg gcaatcgcga 2993281 gcccgagacc cgttccggca gttgaatctt ttgtgttcgt ccctctgtag tagcggttaa 2993341 acaaatgggt gatcgtttct tcatccattc ctttcccatt gtccttcact tttaaagaaa 2993401 tatgattttt tgtttgctcc agaatgactt gaatctctgt tcctttgccg ttgtgcttca 2993461 cggcattccc aaggaggttt tctaatatgc gcctgaacca cgcttcatca agggcaaatt 2993521 caatatgctc ttctttggat acaaacgaga tatcatagcc ttcagaaaac ggatttttct 2993581 taaaatcctc aatgacattt ttaaaaaacg ggataaggct agtgagcttt ctctcaatag 2993641 gaagagcatc atttttcagg cgatacgtta aatttaagtc ttcaatcagc ttagacatgt 2993701 attcagattt ttctctgaca acctgcccca tttctttcac ttcttccggc gaccagtcat 2993761 actgcttcga ctcgagcatc atgctgtagc cgtaaatgct gctgagcggt gtttttaagt 2993821 catgtgacaa accggcaatc cattcttccc ttgtcgcctg gattttttct ctgtttcttt 2993881 tatcccttct cagcgtttca gtcagctgat ccattgattc aaatatctca ccgaagaagc 2993941 ggtacggctg tttgattttt ccctttttat ttttgctgac aggacggcct tcccggtttc 2994001 tgggctcctc aagcttccct tttgacagat tgaccagcca tctaatcgtg tgaaaaatcg 2994061 gcagcccgaa tcggaacata taccaaacgg tcatccaaat gatatacatg aacaaaacgg 2994121 ccatcacgag aaacatcgct tttaatacaa ccttcaggaa tgatttgtta aactcctgat 2994181 cggttacata gactgggttc ggcaccgtag cgaccatcca tctgtcttta ttgaggatct 2994241 taacggaaat ttcccgctta tagttccaag gcttagagct gtatttaagc agctccagct 2994301 ggttcatcgt ttttctctcg ctttttgtgc tgttgatgct gtcgagaatc tttccattgc 2994361 tgtctaacag gtaaatggcg ccttttttcc gtttaatata gtcgatggta ctagacttat 2994421 agtgcgctag tgagtctatc ttttgttcac gcttttcaac ggaagtcagg agctgttcac 2994481 tttttgattt ccagccggac aatagaagat acgacttatc ttcaatattg atggcccaat 2994541 aattcagttt atagttatga agctttttgg ttttataaat agacaaaagc tctttcttgg 2994601 tataggtgcc cggcacgtct tttggcacgc cgtaggaata atcagtgttt ccttccgaat 2994661 caatgatttg catccagccg tgctgtttat caacagattt cttcaggaaa ttatccactt 2994721 cccatgtccc gtcttcgttt acatcgagat atgcctcaag tgtgtcggtc gttgctttcg 2994781 tcagccctga attggattcc gcatcgctaa aacgggcgtc taaatagaaa aacgatgcaa 2994841 caagcataac cgtaagcagc aggatcacaa tcagcatctg gccgaaaaag tgaaacaaaa 2994901 acttccatct taacctcatg accgcttgcc ttcaggattt gggataaaac gatagccgag 2994961 acctcgaacg gttacaatat actccggatt gctcggatcg cgctcaatct tctccctaag 2995021 cttgcgaata tgaaccatga cggtgttgtt gtcaccgtag gaaggatagc cccatacttt 2995081 ttcatatatt tgatctttgg aaagcaccac gttagggtgt tcacaaaaat actgcaaaag 2995141 ctgcagaagc tgggctgaac aggcaacggc ttccccgcct acgatcaact cggcattttg 2995201 cggagaaaaa gtaaagtaat catatgtgta ggtttgattt gaactcgttt ctttcgattg 2995261 atatgtacgc ttgagatgcg ctctgatccg cgccgctaat tccagcggat taaatggttt 2995321 tgtgatatag tcatcagctc caaccgcaaa gcccgataat ttgtccgcgt cggatgatct 2995381 tgccgtcagg aaaaaaatcg gagcgtctga atactctctg atcaatgtgc aggcttcaaa 2995441 accggacatt ccgcccatca tgacatccag cacaatcaag tcaaccttat tggccttcac 2995501 aacgggaatc gcttcttctg cgcttgccgc atccagtata tttcgataac cttctttttc 2995561 gagaacgcgt ttgatcatgt ccacaatcgc tttctcatcg tctacgatta aaattgacgc 2995621 attttccact tttatgttcc tttctgtcac tgtttttttc atcttatcat tatatcgttt 2995681 atttatggta catttttgaa tacattggag ccttggcaaa tcaaaacagc aaaaaaggag 2995741 caaacaagcg ctcccttttg atgttttttc atatgaaaat attatgagtt ctcatctacc 2995801 atgtacaaaa taaactccca aaaccccggt acatcctgac ataaaagcat atcagccttt 2995861 tcaaacattt tgatcttcag ctcttgctct aaatcttctc tttcttgata ggacgtattg 2995921 ctgagttttt ttctgatcat cggtgaaaag catgcaatca ggtgctcaat gtcataagtc 2995981 tcgtcttttt gtttcttttt ttgttcaaac tggccgtcca cagcttactt ttcccccttt 2996041 ttttgcgccg ctaactgctt tctgatattc tccagcccct ttttatgaat gttggagatg 2996101 ttttgtcggg actcccctaa tgaatctgca atctcctgca tcgtggcacc gtgaagatag 2996161 actttcgtca gcacactttt ttgtttgtca gtcagcttct ggatcgcttg gtagagctgg 2996221 taatcctgta catgctggct caaatcatcc tgcctgtcta aaaattcttc aaatgcatcg 2996281 ctacctgttt cggaagaaag ccgatctccc gcctccggat gatcaaccgt cagtggatac 2996341 cgtttttggt ttttgcgaac ccgcttatca aaatcaatag aaaagatgcg aatcattgaa 2996401 ttcatatact tgacgatgcg gatttcttta taaaattgct taaatagctc gtccaatgat 2996461 cttgcatctt tttcgttagg gctttccatt acgtttttga acaaacggta atgctgagga 2996521 ttgctcaaaa aatgcttcac gatgggatgc ttcattatct ccttacattt tgaccgtaaa 2996581 agactttgat agtccatcaa accgcctccc tactaaatta aatgaaggaa agcaaaaaaa 2996641 agtaaactac tactttccgc ctagtgtctt ccaaaatact ttgcagcagt ttacgtttta 2996701 tcggttttcc tcacttacat acatgactgc agaaaaagaa gggaggtatt ttcctatgga 2996761 tcaggttttt atagaggaag tcgtaaaaca gatcggcaat ttggggtttc ccgcgctgat 2996821 tgcaatgtat ctgctgaccc gattcgaaaa gaagtttgat caactaatag aactaatgac 2996881 agaactgaaa gatcatgcaa aaaaataatt tttcaatcga agttgacttt tcactggttt 2996941 ttttcactta acaaaacaga agggaaaacg aaaggccttt caccttctct ttctgctatc 2997001 acatttaaat gtaaggagga aacatttcat gaaaaaacaa aatgacattc cgcagccaat 2997061 tagaggagac aaaggagcaa cggtaaaaat cccgcgcaat attgaaagag accggcaaaa 2997121 ccctgatatg ctcgttccgc ctgaaaccga tcatggcacc gtcagcaata tgaagttttc 2997181 attctctgat actcataacc gattagaaaa aggcggatat gcccgggaag tgacagtacg 2997241 tgaattgccg atttcagaaa accttgcatc cgtaaatatg cggctgaagc caggcgcgat 2997301 tcgcgagctt cactggcata aagaagctga atgggcttat atgatttacg gaagtgcaag 2997361 agtcacaatt gtagatgaaa aagggcgcag ctttattgac gatgtaggtg aaggagacct 2997421 ttggtacttc ccgtcaggcc tgccgcactc catccaagcg ctggaggagg gagctgagtt 2997481 cctgctcgtg tttgacgatg gatcattctc tgaaaacagc acgttccagc tgacagattg 2997541 gctggcccac actccaaaag aagtcattgc tgcgaacttc ggcgtgacaa aagaagagat 2997601 ttccaatttg cctggcaaag aaaaatatat atttgaaaac caacttcctg gcagtttaaa 2997661 agatgatatt gtggaagggc cgaatggcga agtgccttat ccatttactt accgccttct 2997721 tgaacaagag ccgatcgaat ctgagggagg aaaagtatac attgcagatt cgacaaactt 2997781 caaagtgtct aaaaccatcg catcagcgct cgtaacagta gaacccggcg ccatgagaga 2997841 actgcactgg cacccgaata cccacgaatg gcaatactac atctccggta aagctagaat 2997901 gaccgttttt gcatctgacg gccatgccag aacgtttaat taccaagccg gtgatgtcgg 2997961 atatgtacca tttgcaatgg gtcattacgt tgaaaacatc ggggatgaac cgcttgtctt 2998021 tttagaaatc ttcaaagacg accattatgc tgatgtatct ttaaaccaat ggcttgccat 2998081 gcttcctgaa acatttgttc aagcgcacct tgacttgggc aaagacttta ctgatgtgct 2998141 ttcaaaagaa aagcacccag tagtgaaaaa gaaatgcagt aaataaaaga cttgcggctt 2998201 gcagagagca ctcgttctct gcaagccttc ataaggagct gaaccagtga aacatcaaaa 2998261 cccttcaaaa cgcttattgc ggctctccat aaagtacttg ctggccgcag cagcagtggt 2998321 gttgacctat tttgctgtca tctatatatt gttttcttta gcgggaacga gctaccgctc 2998381 agcagctcat gtcctgcttt ttgccgtggt attccttgtt ctcggattat gctttgaacc 2998441 atttgaacgg ctgatgatac atagctttac atttttcaag acaggaaaac gtctattcat 2998501 tctccttgct ggcatcgtac agctgctgtt tttgtggatg actgctcata caacagacca 2998561 attgatcagc gacatctggc tgtccaccac agaagaaatg attgtcgcag ccgttttttt 2998621 gattttagac aaatgcaact cggctcttcc cagctaaaaa aagaacgcat tccaattgga 2998681 tgcgttcttt ttattcatag cgaagcgcgt ctacaggctg aagcttcgaa gccttgatag 2998741 acggaagcaa gccgaagata atgccgactg ccattgaaaa gatgagtgct ccgacaacag 2998801 ctggaatgga gacgataaaa ggcatcggaa aaatgaccgt cagcagcttg gcgatgccga 2998861 agcccgccag cacaccgagt attccgccaa tgcttgtcag cacgacagcc tcggttaaaa 2998921 attgaaataa aatcacacgc cgcttagcac cgagcgcttt cttaattccg atttccctcg 2998981 tgcgctccgt tacggaaacg agcataatgt tcatgacgcc gataccgccc accaaaagtg 2999041 aaatactggc gataccgcca agcagcaatg caaatgactg attaaaggac tccacttcct 2999101 gcgcgatctc ctgaagatcc attacactgt actctgcttt ttccagctca gcttctgaca 2999161 gtccctgatt taaaagatct gcagccatta cacccgcttc ttggatatgc tcagaagaat 2999221 cagcctgcac ggcaatctgc gttggcgcgt caaatccttc aataagcggc cacacttttt 2999281 tcggcacgta caaaaccggg ttcgcatagt cgccttcaaa catgctttcc tgttgatttt 2999341 tttctttaaa aacacccacg accttaaacg gcacaccatt catctcaatg cttttatgca 2999401 gagcttctcc gtctggaaac agttcatctc tgacagcttc attgatcatc actacttggt 2999461 gtgtgctgtt taaatcgttt tccgtcagct ttctcccttc ggttattcgg attggaaaca 2999521 tgtcgaagta atcatcgtcc actccataca cttggggata cgaaacgtta gttaaatgaa 2999581 aaacgctcgc gccttctgac aagtaatata aggataatcc tttgaccatc ggatctgatt 2999641 tgatcgcctt tactgtttct tccgctacag gcggcgcgga cgcatacgac acctgagggc 2999701 cgccgctctc ctcttctccg ccagacggct ggtagacaac attgatggcg ttgtttccca 2999761 tgccgatcat actttgcttt aactgctcac tttggccctt cagcattgaa acaatcgcga 2999821 tgattgccgc tatgccgata atgacgccaa gcattgtcag aatcgatctt aatttatgag 2999881 agaaaatgga ttgaaaggag attcgaatat gttcaagcat ggctgatatc ccctctctca 2999941 tctaatacca actctccgtc tctgataaaa acggttctgt cagctttttt ggcgacgtcc 3000001 gggtcgtggg ttatcataat aatggtcttg ccttcccgat gcagttcaga aaacagtgcc 3000061 aaaatttgtt cacttgattt ggtatcaagc gccccggtcg gttcatcagc taaaataaac 3000121 ctcggctgat tgacaagggc cctcgctatc gccacccgct gcttttggcc gccggacagc 3000181 ttaggcggtt tgtaggagac cctgtctttt aatccgactt tttccagcgc ttcatatgcc 3000241 cgttgccttc tctctttttt cttcacttta ttgtagatca tcggcagctc gacattttgc 3000301 agcgcggtga gacgcggcag caaatgaaaa gtttgaaaca caaacccgat tgattcattg 3000361 cgaatttcgg ctaaagcccc gtctttccct ttcaatatat cgatctggtc aagcgtatag 3000421 gttcctgagg ttggcctgtc caaacagccg ataatattca ttaacgttga ctttccagaa 3000481 ccggaaggcc ccataatagc taaaaactcc cccgcctgaa cggtcagatt gatatgtttc 3000541 aagattggaa cttcttcttt tcccagcttg tacgacttcg aaatattatt cagtgtcagc 3000601 attgactgta acctgctttc cttccttgac cgcgggatca ggatagatca cataatcttc 3000661 cggcgtcagg ccgctcttaa tttccaccat gtcattttca tcagtctctc cgatttcaac 3000721 aggctgctta accgctttgt gattctcatc agctttccat acgtacggtt cgccgtcatc 3000781 ctgaatgacc atgtcggacg gcagcttgat cgtgtccgca tcagcattat cactcatcac 3000841 ttcgatgttg acatgatagc cgacttcaag acctttatgg ctgtctaata aaatggtgaa 3000901 aggatagtta gaggactggg gattcatttc ttcatcagca aagctttctg attcttcacc 3000961 ctcgcctgct cccgctggaa gcttgccgat cgaggtgacc tttcctttcc actcgccctc 3001021 accgcctgtt ttcagcgtga ccctgacttt gctgcctttt ttgatcgtgt ccattaacag 3001081 ctcattgatt tggcttttga ccagatattt gcctgtcgaa acaatctgga tatacgggcc 3001141 tgctgcctgg tcgcctgttg caccgtcagc gatatcctga ttgacgcttt gaacgattcc 3001201 gtcatgcttg cttgtaatga cattggaacc tttgtttttc gtcaggccag ccagttcttt 3001261 ttgatgctgc ttcagttcaa gctggcttgt tttcaaatcg aaattggttt gatcaagttc 3001321 atcttgaagc tggtttttct cttcttttcc tgcaactttc agcttttttt ccgtttccgt 3001381 tattgatttt tgcaaacggt tgatttgcag atttgtcatt tcaatttgca aattggcttg 3001441 ctccacttca tcagaatgat cctcgccctc atactcaaaa agcttatcgc cctttttaac 3001501 ctgatcgcct tctttgacgt atgttttttt aatgctgcct ttttctgaat ctatgtatac 3001561 tttctgctgt ttctcaggtt caacctttcc agaaaacgtt tggcctgatt ctgaatctcc 3001621 tcccatgtat accgcgaccg attcagcata gggctccgat gatacggcaa cttggttcat 3001681 gtgagtaaaa aagtaaaaac cgccagcgcc gatcccagcc aatacaagca caccggcaca 3001741 tatcgcaccg ccaataagcc attttttctt cttggacaca acgatctcct ctttctgtaa 3001801 actatgtaat attttcgaaa cattctaacc aatattatct attaattcaa aaagacttgc 3001861 aatcctttta ttgaaatgac ggaatcaaat agaaaaattg tattttcaaa gccgaataaa 3001921 aaaaatcccg gcttcaaacc gggatttttt catacagtaa ctagctcttt ttcattttta 3001981 atcaagtcat atgtcaagca tacaggttta tttgtacggg gatcagtcac gatttcggca 3002041 tcaatctgaa atacctgctt caaaatgtct ggtgtcatga cctccagagc agttccttcc 3002101 ttgatgaccg tgcctttttt gagcgcgatc atataatgag aaaaacgagc tgcatggtta 3002161 agatcatgaa tgaccattaa aatcgtccgc ccttgctctt tgttgagtct gtcaagcagc 3002221 tgcagaattt caagctgatg tgcaagatca agatacgttg taggttcatc cagcagaagc 3002281 agttccgtcc cttgcgcaag cgccatggca atccacacac gttgacgctg tccgcctgac 3002341 aatgcctcaa tcggccgttc agcatattca gccatgcctg tttcttcaag cgcccatttg 3002401 ataatccggc ggtcttcgtc atttaatctg ccgaatcctg attgatgcgg aaacctgccg 3002461 tacgacacca attcgtgcac tgttaggccg ctcggcgctt caggtgtctg tggaagaatc 3002521 gccatatctt ttgcaatgtc ctttgtagac attttatgaa tcgctttgcc gtttaaatag 3002581 acggcacctg catgtgaacg cataattctg gacattgttt ttaaaatcgt tgatttcccg 3002641 cagccgttcg ggccaattaa ggtggtaatt ttccctttag gaatcgatat atttaaatcc 3002701 tctacaatca ccctgtcgcc ataaccgatt ccaagctgtt ccgttgataa tgaattcata 3002761 ttcggccccc tcctctaatt cgctttcatc aataaataaa taaagtaagg cgcacctagc 3002821 acggaaatga caagtccgac cggaatttct gatggtgcca atacatttct cgccagcgta 3002881 tcagcaagca aaaacaggaa tgagccgatg aaggcggaga ccggtatcag cgtctggtga 3002941 cgtggaccgg tcagccttct agccacatgc ggcgcgatca atccgagaaa cgcaatgccc 3003001 cccgcagctg ccacgcatga agcggcaaga gtgaccgctg ccagaagaag aatccgtctt 3003061 tccttttcaa cagcggtgcc cagcccggtc gccaattggt ctccgagctg cataatgttc 3003121 aaatagcgtg ccttatataa agtaaacaga agcaagatca caatccaagg gagaatcgcc 3003181 cagatcatat tccagttcgc cccccatatt gagccggata tccaaaccgc ggcttgcata 3003241 aaatcatgag ggtccatctt gagctgaaaa atcagcaaca gggcgttgaa tccggcattc 3003301 acccctatgc cgactaaaat cagccgaatc ggtgtcacgc cttttttcca tgccagaata 3003361 taaatgagaa acgcagcgag gattgctcct gccaaagcac tgaacggcag cataaatgtt 3003421 ccgaaaaagc taagatctga agctgaccct tgaaaaaagt atataaaaag cactacagca 3003481 agtgaaccgc cggcgttaat tccgagaata ccaggctcgg caagttcatt ttgagacacg 3003541 ctttgcaaaa tggctccagc tacggagatc cctgctccaa caagcaaaga aaggatgatc 3003601 cggggcagcc tgaactcaaa taagacaagt tcatcacgcg ccgttccttg gccgaaaaag 3003661 acctgaagcg ttttaagcgg tgcaattttg ataacgccca aattgagact gataaaaaag 3003721 accaccacga taagcaaaaa ggtcacagcc attacaatga gcggtttgtt tgtttttgtt 3003781 ttcattacag ccctctcctt tcacgacgtg ccaaataaaa gaaaaaggga acgccgataa 3003841 gagaagtcag cgcgccgaca ggcgtttcaa agggcgcatt tacgagtctg gccgctatgt 3003901 cagcaaaaac aagcaaaaca gcaccgagca ccgccgagca aggaatgatc caccgataat 3003961 ccacaccgac caaaaaacgg gtaatatgcg gaatgatcag cccgataaat gcaatggtgc 3004021 cggcaatgga aaccgcagct ccggtcagaa ttactacaat aagcatgcca accagtttca 3004081 ccgctgatgt atattgtcca agcccttttg ccagatcgtc accgagactt aacactgtaa 3004141 cagaccgggc gatgaaaaac gcgagcgtta aaccgacagc ccctgcaata agcaaaagct 3004201 ggacccccga ccatttcaca cccgctaccc cgcctgcgta ccaaaagctg atatcctgag 3004261 cgacatcaaa gcggattgca atggcagttg aaatgccggt aaagaaataa gtaactgccg 3004321 tacccgccag agcaagcttt acaggcgtaa gtccgcccct tgaaaacatg cctatgccca 3004381 ttaccgtcga tgcccccagc cccgctcccg caaaggacca tagcacaagc cccattgcag 3004441 aaagtccggg aaaaaaggca aacgcaatcg aaaccgcaaa cgcagagcct gatgtcacac 3004501 ccataatcga aggctctgcc aaagggtttc tcgtcatccc ctgcatgatt gctcccgaca 3004561 ctgccaacaa tgcgcctaca agcgcggcag ccgccgttct cggaagccga agatcatgta 3004621 taatttggtg agatgtcttt gtcggctgat aatgaaaaat ggcctcccat acagtgcgca 3004681 aatgaatatc cgctgcacct agggatatgg ataaaaatgc gccaaggcaa agcaggcata 3004741 gacctgcgat aaggacgatg accgcgccat atgtccttga cgtccattgg atttcttctg 3004801 atgcagtccg tatattttta tgttgactca actgccgtac ttcctttctg ttactgataa 3004861 tgattatcaa ttgctgtttc agtatatcac ttttttcagc tgatttaata gagtgttttg 3004921 aacaaaaatg aaaatgcatt tgcaaaaata tcgtgtcaac cggcacttgc agtggtataa 3004981 tcacagatga taatgattct ctttttcatc tatcttttag aaagaaggta tgagatatga 3005041 cccatatata caagaaactc ggagccgcgt tttttgccct gttattgatt gcagcgctgg 3005101 cagcctgcgg gaataactca gaaagcaaag gttctgcctc tgattcaaaa ggcgcagaaa 3005161 cctttacata caaggctgaa aacggaaatg taaaaatccc gaagcatcct aaacgggtgg 3005221 ttgtcatggc agacggctat tacggctact tcaaaacact cggcatcaac gttgtaggtg 3005281 cgcctgagaa tgtatttaaa aacccttact acaaaggaaa aaccaacggc gtcgaaaaca 3005341 tcggagacgg cacttcggtt gaaaaggtca ttgatttgaa ccctgacctg attatcgtct 3005401 ggacaacaca gggcgctgat attaaaaagc ttgaaaaaat tgcgccgact gtcgcagtaa 3005461 aatacgataa gctcgacaac atcgaacagc tgaaagaatt tgcaaaaatg acgggaactg 3005521 aagataaagc tgaaaaatgg ctggccaagt gggataaaaa agttgcggcc gctaaaacaa 3005581 aaatcaaaaa agcggtcggt gacaaaacca tttccattat gcaaacgaac ggaaaagaca 3005641 tttacgtatt tggtaaagac tttggaagag gcggaagcat catttacaaa gacctcggcc 3005701 tgcaggctac aaagctgaca aaagaaaaag ccattgacca ggggccaggt tatacaagta 3005761 tttcattaga gaagctccct gacttcgccg gagattacat tttcgcgggc ccatggcaat 3005821 caggcggtga tgatggcggc gtttttgaaa gctccatttg gaagaacctg aatgccgtta 3005881 aaaatggcca tgtatacaag atggatccga tcggattcta tttcacagac ccgatttcat 3005941 tagaaggaca actggagttt attacggaaa gcttgactaa ataaacaaaa gagccgcctg 3006001 cccgcggctc ttttgcttat ttataaggaa cggctcaatt tgaatcatat cggatatttt 3006061 ctttgagcca ttcatattaa gctgcatcct catcacgatc agttttttta tgctggagag 3006121 actgaaaaac gttttttgca tatttaacga acggattcct aacaggagaa attgtgattt 3006181 tataaaaaag acacctgagc aaatcaggtg tcttttcatt atgcttgttt ttctttctgg 3006241 aacttgttac tcacaaatgg ataaacgatt aagccgacaa agaataaacc gatgccgagt 3006301 ataaatgtcg ttaaatctgc tgtgcctgtt acgataacaa acacggagta tgcacacgcc 3006361 agtatcgcga tcaatccgtc tcttacacgg gagcctttca gctggtcata cgtttcacct 3006421 ttgatgacta ccttcaagct gtagattgca gataccagat acggaattaa atatgcgagt 3006481 gtagccgctg tcgttaaaaa tgtaaatgcg tcacttattg tccgggaaat aaccgagaaa 3006541 atgaagacct gtgacatgac gtttgtaata atgagtgcaa tgaccggact tcccttttta 3006601 ttcgtttttg caaaaaatgc cgggaaatct cctgctttag cggcttggta tggcacctca 3006661 gagccaagca aaatccagcc gagcatcgtt ccgaataaac aaaggatagc caaaagcgcc 3006721 ataatcacgc ttcccgcgtt tccaacaatc gcatagagta catcaacaaa tggtttttca 3006781 gagccgacaa gcttatcatg cggcagaaca cccatcgtaa ttaaagtcac aataatatat 3006841 atgctcaagg caatcagcaa gccggtaatt gtcgcacgtt tcacatcacg ctgagagcgc 3006901 gcacggccgg acaggatcac cgcggattca attccgacaa acgcccacag tgtagaaatc 3006961 gcagcgttat gaacctggcc accaattcca atgcttgtgc cgttttctcc ttgaaccggg 3007021 aaataaaaat gaccgaataa tgacgtttga aacacaaaca aaccggcaac gataaagaag 3007081 acaaaaccta atactttaga aagcgttgtg acaaagttta atttacttgc gccgttaatg 3007141 ctggcaacaa gaatcgcgtg cgttccccat aacaagatcg tacatacggc aaacgtcagt 3007201 aattggccga gtgtcacctc ttgcccgccg atcgaaaaca tctcacgttt atcaaccaag 3007261 atcgggaaga acgaagtcaa gtaaccggcg agacttgtga tgatcgccac gttactgatc 3007321 cagctcgcca cccagtagcc ccacaccatt gtgaaaccgg cagcgttgcc ttttttcggg 3007381 tcagaaaaca gcgctcttgc ataactttgc ggtcccgctg tcagttcagg cttgcgaatg 3007441 gacaagtgtc cgaacacaag tgcaatcatc agcacgccgg cacctgtcaa aagccaggcg 3007501 gacgtagctc caaacggact cgcaattgaa gcaagcgagc tcggcaagga gaaaattcct 3007561 gatccaacca tatttccaac gacaaacgcc gttaataacc aaaaacccca tttttttgtc 3007621 tgttccattc cagtacctcc atgattcttt gtacggacca gaccccgaga tcatataaac 3007681 gcaaaaaaag cctgaacaaa agtccatgct taaagaaaca cacacccttg atctccggat 3007741 agccctccgc gaaaaagcac gcggcagtcc tgcacttatt cagatacagt cccagcatag 3007801 agaaggatcg gctttctcca cacttcggcg ctgatgcctt ttacacatgt ttaacagccc 3007861 ctgtcagcct agcatgtgtg actcatcatc cgcgcaacct ctacctcact gagaaagagt 3007921 gaggatttaa ttattcagtt actcccagaa ggttatcaaa gaaaggatga tctgtcaaag 3007981 ggaacagatg gaaaatacgg atagagccaa gccctatccg catgtggtta tcgattattt 3008041 ttcttttttt gcacagcttc ttgaagcgga tcatctttta gagctgaacc agcatcttca 3008101 agagctcctt ggattacgtt tttttctttt tcggaacgtt ttcctttatc tttattaaag 3008161 aaacccattc gtatcacctc ttttaaaaaa taggtacatg tttaagatgc ctttttcctg 3008221 aaaaattatg cgggatattt tttatcgtcc aaagtcctgt tgatcaaaca tacattctct 3008281 tgatatattt gtaattcaga gattttttgc aaaagataaa aggagaagcg gcaaatgaca 3008341 ggaaaaacac acatcatggg aggcatcgct tcttgtacgg cagcggctta ttattatgga 3008401 tttgatccag tgcttatggc tgcgtcaggc gcggttggag cattaatacc cgatatctgc 3008461 cacacacaaa gcaaaatcgg gagaaaattt cctattttat cgaaagtggt cagctccgtt 3008521 tttggccatc gcacctttac acacagcctg ctgtttatgc tcatcatgtt ttttatcact 3008581 tctacataca ttccagataa aaacatatca gccggcctga tgatcggaat ggcgagccac 3008641 ttgattcttg acgcttggac ggtgaacgga atcaaattat tattcccttc cacgatccgc 3008701 gttcggcttc cattatatat gaagacaggc agtttttctg agcagctcgt gctagccggc 3008761 ctgacccttg cttcatgtta ctacttttat atgctgtttc atggccgcat gttttaaaca 3008821 tgagtgctga gacttgtctg aaccggctgt ttttagtagg ttttacttaa gaagcatttc 3008881 atgcagatga tcaagaaaac gtgaggagtc atattgatga aaggaacctt ttttcacaat 3008941 cagcggtttt tatgtttttc gatcttattt atgtggatca aaacgtatgt gatatataaa 3009001 ctcggctttg atttgcaaat cgatactctg ttggaggagc taatgctgct ggtcaacccg 3009061 ctcagcttta ttcttccttt attcgggatc ggcctgtttc taaaagaaaa caagcagcgg 3009121 gcctttttgc tgattgccaa tttggttctg actgttatct tgatctctaa tacgattttt 3009181 tacggctttt atatcgattt tattaccatc ccggttttat ttcaggccag caacatgagc 3009241 gatatgggca gcagtgtaaa agaactgttc catcctctgt ttatcgccct gtttgtggat 3009301 ttggtttttc tgctgttgtt cgccagaaaa accaaacacc cacagacaaa agccgctccc 3009361 cacacgatca aacggtacta tgcagcttcc tgcggaatgc ttttatgcac actggcactt 3009421 gcagaagtac agcagccgaa gcttttggca cattcttttg accgggaaat gctagtcaaa 3009481 agcatcggcc tgtttcagtt ccatatttac gatacaattt ctcagactgt taatatcagc 3009541 gcgaaagctt ttgccgatga agacagtata actgccatta aaaactacac agaggctgat 3009601 tacagcaagc ctgatcaaag caaattcggt cttgcaaagg ggcgcaatgt catctttgta 3009661 acacttgagt cgacccaaag ctttgttctg aatgaaaaag taaatggaaa agaaattacc 3009721 ccatttatga atgatctcat aaaaaaaagc tattcctttg atcatttcta tcagcaaaca 3009781 gaacaaggca aaacatcaga ttcagaattt atcgtcgcta actcactgta tccctccctt 3009841 agcggcgccg tctttttcac gaaaagcgac catcaatttc atacgatgta taaatcgctg 3009901 aagcagcacg attattattc agccgtcttt cacgctaacc ataaaacatt ttggaacaga 3009961 gatgtcatgt acgatacatt tggcattgac cgcttttttg atgttgatga ttttcatgtc 3010021 actcccggga catcgacaag ctggggctta aaagacaaag aatttttaga gcagtccgcc 3010081 aaaaagctga aaagcctacc gcagccgttc tacagcagtt ttatcacgtt aacgaatcat 3010141 tttccgtttg agattgatga aaaggatcag ctgatagatg aattcgattc aagcagtgat 3010201 ctgttaaacc gctatgtgac cacggttcgc tatgaggatg aagcattgaa gcattttatc 3010261 aaaaaactga aggacgaagg cttatacgaa aattcgatga tcgtatttat gggagatcat 3010321 tacggcattt ctgaagccca taacgaggca atggctgagt ttttagggaa agacgaaatc 3010381 acaccgtatg acaacgttca gctccagcgg gtgccgttta tcatacatat cccgggaatc 3010441 accgatcaac agccggaaac catccctgat gccgggggac aggtcgacgt caggccgacg 3010501 ctgatgcatt tgctcggcgt tgagacaaaa ggcgatatcc aattcggcaa tgatttgctg 3010561 tcgggcgacc gcaccccatt cgccgttctg cgaaacggca gctttattac gaacgattat 3010621 gtatacacaa agaacacgtg ctatagccaa aaaacaggtg aagtgctgga agatcaggat 3010681 gcgtgcctcc cttacaagga gaaagcaaac gaagaactgt ctctctctga taaaatttta 3010741 aatggtgacc tgctcaggtt ttccgaatga aaaaatccct ctatcaagag ggatttttta 3010801 cgtttccaat atcaccttgc cagtcagctt cgtttcatag ccgtttaaat gagacagatt 3010861 cgccttgtag tcctcagaat tcaaaatctc cttcacggct ttgagcaact gctcattttt 3010921 tttcaaaaca acgatatcat attgttcgtc gatgagcggg ataaaatcaa cactgcccat 3010981 atgtgccgcg tgctgtgccc cgattcccgc gtcagcctgt ccgcttgaaa cttgtgaagc 3011041 ggcagcgtaa tgatcagtca cgatatcgcc atatcccact acatcagccg gattcacacc 3011101 aagcaagcca agctgttcat caaggagcac ccttgcgcca gaaccctttt ccctgttgat 3011161 gatccggata tcggctcttt tcaagtcttt ccagccttga atgtttttcg gattcccttt 3011221 ttgcacatac agtcctgctt tgcggagaac gacattgatg agacaaaacg gttcacctgt 3011281 caaaatccgt tttacataag gcgcgttata ctggcccgtt tctgcatcgt acaaatggag 3011341 gctgacaatg tcacacttgc cttgatacat atcaatcagg ctgtttaagc ttcctttgta 3011401 tttacggagc ggcgtctcct gaatggcatt ctccaaatgc ttgctgagga tatccatcga 3011461 aatgtcctgt ccgctgatca tgacatttgg tctgccgtcc ggctcagcct cctgcacctg 3011521 tttcggcgct tcttttgcag cgatgggctg agacattctc atattcgttt tatattgctt 3011581 taaatcttct tcatccacac gcatctgcct tccgacacgg taagcaggca gcacgccttt 3011641 tttaatcaag tcataaacgg tcagctttga taccttcagc agacctgcaa cttcttctat 3011701 cgtataggaa gaggtttcat tcatcatcat cactctccta ttttattata ccttttcgcc 3011761 gaatgtaaaa aaacccacat aaaccaaaca taatcagtta taattagtta tatctaatga 3011821 taaggggtgc aatcatgttt aagaagtatt ctattttcat cgcagcctta actgcttttc 3011881 tgcttgtagc aggctgttct tcaaaccagt cttcaacgga cagcgagaaa aaagtaacgt 3011941 taaccatctc agctgccgcc agcgcgcagg atgcacttga ggaaatccaa aaaaattatg 3012001 aaaaagatca tcaacatata accatccaag ataactatgg ctcatccggc gccttgcaaa 3012061 aacagatttc tcaaggagca ggagcagatc tgttcttctc agctgctgag gataaattta 3012121 aaaagctggt ggatgatgga gatatcgcaa aaaaagacag cactgaatta gtcggtaatg 3012181 aaattgtgct ggtcgtaccg aaaaacggag attcacctgt gacaagcttc agcaatctgg 3012241 ctgaatcaga aaaaatcgct cttggcactc cggaatccgt accggcagga gcttatggga 3012301 aagaatcact gacaaagctg tctttatggg acaaagtgaa ggataaaatt gtgtatggaa 3012361 aagacgttcg ccaagttctt tcttatgttg aaaccggcaa tgtagacgca ggtgttgttt 3012421 ataaaacaga tgccctagtc tcgaaaaagg tcaacattgt tgacgaggca aaagcagata 3012481 cacacagccc aattgtctat ccgttaggaa tcgtaaaaga tacaaaacac cgtaaggaag 3012541 cgaaggaatt ttacgaatac ctgcaatctg atgaagcaat gaaagtattt gagaaatatg 3012601 gctttactgc cgagtagcat aagcgcttca gaatttttca cacccgttgt gctttccttt 3012661 caggtggcgg cagttgccgg aattgttgtc attattctcg gaacacttgc tggagcatgg 3012721 atgtcacggg catcattttt cggaaaaacg gcactcgaaa catgttttat gcttccgctc 3012781 gttcttccgc ctactgttgt cggttttatt ctgatcgtca ttttcggaaa gcacagcttc 3012841 atcggacaag ccatcgagtg gattttccag cagcctgtca ttttcacctg gtgggccgct 3012901 gtgatcgcct cggctgttgt agcctttccg cttatgtatc aatcagccaa aaccggattt 3012961 gctgacattg atcccgatat acaaggtgcg gcaatggtag acggcgctag cagatggaaa 3013021 gtgtttatcc atatctccgt cccgcttgcc tatccttcgt tactgaccgg aagcatcctt 3013081 agccttgcgc gggcgctcgg agaatttggc gcaacactca tgtttgcagg aaacatcccc 3013141 ggtgttacgc aaacactgcc gacggcgata tatgtcgcat tggattccgg caacaatacc 3013201 cttgcttggg cgtgggtcgt ctgtattgtt gtcatttcct ttttgatgct gtttttcatt 3013261 caacagaaaa aaacgcacta aaaaaactcc ccataacggg gagttttttg attaaaacag 3013321 aagctcatca ggatttggac cgacacgctc atctttattt aatgcgtcaa ttttgtccat 3013381 gtcttcttga gacaattcga aatcaaaaat atcagcgttt tcgatgatac ggtgttcttt 3013441 aatggatttt ggaatggtta caactccatg ctgcagatcc cagcgcaaaa tcacttgagc 3013501 cacagattta ttgtgttttt cagcaatctg tgtcagtact tcgttatcca aaagctgtcc 3013561 ctgcatgagc ggagaccacg cttccagctg aatgccttgc cctttgcagt aatctcttaa 3013621 ttctttttgc gtcaagcgag ggtgaaattc aacttggttc accatcggtt tgatttcagc 3013681 atctttcaac agctcttcta aatgatgaac ttggaaattg ctgacgccga tcgcgcgaat 3013741 tttgccgtct ttgtacagct tttcaagcgc gcgccatgta tctttatatt tatctttgcc 3013801 aggccaatgg atcaaatata aatctaagta atcaagctgc agtctttcta ggcttttttc 3013861 aaaggcagca agcgttgttt catagccttg atcttcattc cacacttttg atgtgatgaa 3013921 gagctcttct cttgccacac cggattcttt aatcccgatg ccaacgcctt cttcattttt 3013981 gtagatcgct gctgtatcaa tactgcgata gccattttta attgccgctt tcactgattc 3014041 agtcgcttca ttaccatttt ctactttaaa aacgcccaga ccgaaccaag gcatttcaac 3014101 tccgttatgt aactttacag tatcttttaa acttgttggc acttgaacct ccaccctttc 3014161 actgaaatgt aagcgtctat attatctcac attcctctca gccgatacca ataatacgct 3014221 taagaccctc tttttgcttc ttttttcaca gcacaggcaa atccaaacac tatttttttc 3014281 ctattttaac aatattgaga ttacaaatac attgagcagg gtatgcgtgt agtgtaacca 3014341 aatgaaaaca aaggaggaaa caacttgaaa cgtattcgta tcccaatgac acttgctctt 3014401 ggtgccgctt tgacaattgc ccctttgtcc tttgcttccg ctgaagaaaa tcctgctccg 3014461 aagatgtcgc agacaactac tgctggaaca actgccgctg atgtaggttt aaacgtcaac 3014521 ctggatgtac ttggaattgc caaccagatc gctgatgcca tcaaatccgc acagaatagg 3014581 gatggctttg tgaaaaacct catggagtct tccttctacg cgtccggcca aaaatataac 3014641 gtcatggtct ttaatttaag ccaggaatat gaagatcatt tgaacggtgt gcaattttac 3014701 ggctcagccg tttacgacgg cattacgtat ggcatttggg tatttgaaga tggaaccttt 3014761 acaaacaaag gcgatggcgg ctggatcaac tgggccttca gaggctggtt cgaccgggat 3014821 ggcagcactg tcgcatttca tcgcccttaa tataaaaaaa gctggcgctc taacgccagc 3014881 tttttttctg catttattcg ccgccttcaa gcatggcggc ttcgacatca ttaatgtatt 3014941 ggcgaagctc atgggagatg tcccgggaaa tttccctctc ttcgaagagc gtttgaattt 3015001 catttctgat cgcctgcaca gccttcagct tcacttccag cttctgattt tcaaaatggg 3015061 cacttgattt taactcatga tggctgtgct ccagcctgaa aattaactgc ttatagaatg 3015121 taatgacaga taaaaacact tctttatgct catccgtctt atgtttttcc agatattcta 3015181 tcgctgcttt tgccgttttc actcttgttg cccgtatcaa tcccgcttca tttaaaatcg 3015241 acatctccgg ctttttatgt tcaccgaaga aaatccaata catcagcctc ttgagccttg 3015301 tttttgataa cccgacttta aacgggttgg catacaaaat ttccaactcg ttaaatcgtt 3015361 cttgcagcac atttgctgtt tcttccggga tgtctccccg ctccagcatt ttcatcagcg 3015421 cctcttgctc agccttaacc ccctgcgcac ggacttttcg ctcgtgcttc ttaatgcgat 3015481 tagatgatgt atactgctga aaacgaagat ttttcatttt ctcattgtat tcagctatca 3015541 ccgcaagaga ggccgttttg tttgtctcat tcatgtcctc tttaatcgtt tgaagggctg 3015601 ttttgatcaa cttgcgtctc gccgtcagca gcttcttatt tcgttcctcg tcctcttctt 3015661 ctttttcagt cagaattggc agcacaacgg tggcaatgac aagcgtgcat aaaatgacgc 3015721 cggctgctaa aaagagaatc agatttcttt ccggaaacgg cgtaccgtcc tccaggaaat 3015781 acggaatgga aaaagaacct gcaagcgtta ctgctccacg cacaccggaa atcgaaatta 3015841 acagcgtcga acgaagaccc ggtttataga tgttctgatc tttattaaag aaccatttgc 3015901 cgttccagaa gaacagcacc cacaggaatc taaggagcat taatgtaaat gtgatgacta 3015961 ggatatagcc gatcaccttc atgttgctga tggcagtgtc gttaaagata acagaaataa 3016021 catcagggat ttgcgtgccg agaataacga agaccaggcc gttcaaaata aataaaataa 3016081 tgttccacgt acttgaggag acgatttgca gcttgatcat cgttgattcc agacgatcct 3016141 gttcaaccgc atgggtaata ccgccagcta caacagctaa aatgcccgaa acgccgattt 3016201 cttcagctgc caaataaatc acaaacggcg tcagaatttg aatcagcata tgcatcgtga 3016261 catcctgcat gccaaggcgg cgcagaaata ggcgaaaacg aataatcaaa aatgaaatga 3016321 caaccccgca cagcaagcct ccgagagaaa taaagacaaa gctgacagcc gcttgtgcta 3016381 atgaaaatgc accagtcact gccgctgcaa tcgcaaactt aaaggccacc agacctgatg 3016441 catcattcat cagcccctca ccttccagca ggcgaagaat cccttttggc attttcactc 3016501 ttcctgataa tgcgctgaca gcgacgacat cagtcggtga aagaatggcc gcaagtccaa 3016561 aggccgctgc cagcggaata gcaggaatca tccagtgaat cgtgtagccg cctacaatca 3016621 cagtcgcaaa tacaaggccg agtgcaagca ataaaatcgg agcccttaaa ttccaaagct 3016681 ctgcccgcgg tgtcctcttt ccatcattaa atagcagagg cgcgataaaa agaacaaaaa 3016741 acaattcggt gtttaattca aaatgaagtc cctgtggaaa tgaggcggca agaatcccaa 3016801 gagccacttg aatcagcggc accggaataa acggaataaa ccggttcacg atattagaaa 3016861 tcgcaataat cgttaataat acgagcacaa ctaaaaatat gtccaaatgc atgacctcct 3016921 tcgtctgttg tgtgtcggca tgatgagcca aaaaatctgt ttgtctaaaa gcccttgagc 3016981 tagggtggcc ttgcatccgc tatgtggttt cgcaggagtt ctctccacac ttgtcttctt 3017041 ttatagtacc ctttttaggg tattttttct catgatatgc tcacagtgaa cttttttgca 3017101 gaagagcaaa ttatagaaaa aagagacagg aagctactcc ctgtctctcg tctttctttc 3017161 tcaatcatga aaattcgtac cgtcagttgt tgctttaata atgcccgcgc gaatgacaaa 3017221 gtcaccgaaa tgctcgcctt cctcgcgttc tttcgcatag cgggaaagaa ggatgcgcag 3017281 ctcgcttaaa atgtctgctt caccgatgtt ttcacggtac attttgctta aacggcttcc 3017341 gtcaaacgca gcgccaagat acatattata tttgcccggc gcctttccga taaatccgat 3017401 ctcaccgagt gcatgacgtg cacagccgtt cgggcatcct gtcatgcgaa tggtgatttc 3017461 ctgatcacga aggccgtttt cgtcaataat ctcttcaatc ttatctaaca gggtcggcaa 3017521 ataacgttct gcttcagcca ttgccaatcc gcaggtcgga agagcgacgc acgccatcga 3017581 gctgcggcga agcgctgaat agtgcttgcc gtcagttagt ccgtactgtt caattaaagc 3017641 actgatttct tcttttttat cgcttgaaac gttcgcaatc attaagttct gattggctgt 3017701 cagccggaac tcacctgtat gaactttggc gatttcccgc aagccagtca tcagcttata 3017761 atcatcgtaa tccgttatac ggccgccttc gacaaacagc gtgaaatgcc atttatcctc 3017821 gatgccttcc acccagccat agcggtcgcc gttatgatcg aaatgatacg gcttcgcttc 3017881 ttccaggctc cagccgagac ggttttccaa ttcttctttt acgttttcta aaccgaggcg 3017941 gtcaactgtg tatttgaacc gcgcattttt acggacagaa cggttgccgt aatcacgctg 3018001 aatcgtaatc gttttttcag caacgtcata catttgctca ggccggcaga aaccgatcac 3018061 cttggctaat tgcggatatg tcgcagtatc gccatgcgtc attcccatac cgccgccgat 3018121 tgccacgtta aaaccgatca gcttgccatc ctcgacaatc gcaatgaatc cgagatcttg 3018181 tgaaaagacg tcaatatcat tagacggcgg aacggcaata ccgattttaa acttccgcgg 3018241 cagatagagc ggtccgtaca ttggctcgac ttcttcctcc ggcgtgccgg caactctttc 3018301 ctcatcaagc caaatttcat gatatgctct cgtccgcggc agcagatcat cacttaattt 3018361 tttagaccac tcgtatacct ctgagtggat ttcagattga taagggtttg atgcacacat 3018421 gacgttacgg tttacgtctc cgcaggctgc gatcgtatcc aaaagtgctg agtggatcgt 3018481 ctgaatggtt ttcttcatgt tccatttcag aattccgtgc atttggaatg tttcacgtgt 3018541 cgtcaatttt aatgtgccgt tcccgtattt ctgggacagg tcatccatga caagccattg 3018601 ttcaggcgtc gagacgcccc ctggcatacg cacgcgcagc atgaactgat atgcgggctc 3018661 aagcttctgc ttttggcgtt catttcggag gtcgcggtca tcctgcaaat aactgccgtg 3018721 gtgtttcatc aggcggttat catcatccgg aattcccgca ctgattcgat cgagcatcac 3018781 ttctttcagc gtgccgcgca aataatcact ttctttttta atgcgttcaa catcacttgg 3018841 agagccgtcc ggtgctttta gaattttggt caccatgttg aaaaactcct ttcaagtcaa 3018901 atcaatatac atcacgctga tagcgttttt gctgctgcat atcggcaaga taagcctccg 3018961 cctcttcgcg gctcatattg ccttcttttt cgataatttc aagcaatgtg ttatggacgt 3019021 catgcgccat gtgcttttca tctccgcaaa tgtaaacagc cgctccttct tgaagccatt 3019081 caaacaattc tgcgctatgt tcaagcatgc ggtgctgcac atatactttt tcttccgtat 3019141 cacgtgagaa cgccacatcc atttttgtca gcacaccgtc tttgagccaa ttctgccact 3019201 ctgtctggta aaggaaatcc gtgacaaagt gctgatcgcc aaagaacatc catgcctttc 3019261 cttccgctcc cgtctcctca cgctcctgca taaacgaacg gaaaggtgcg acgcctgtcc 3019321 cagggcccac catgataatc ggtgtttcag ggtctttcgg aagcttaaag ttttgattgt 3019381 gctgtacata aaccggcagt gtgtctcccg gctgcagtcg ttccgcgcac aaaatcgagc 3019441 agacgccttt tcgttcacgg ccgtgcgcat cgtagcggac tgcgccgatt gttaagtgca 3019501 cttcatccgg atttgcggat aaactgcttg caatcgaata aaggcgggca ggcatttttc 3019561 gcaaaatcga gacaaactcc tgcgcagata cactaaatgg gccatagtca cggacgagat 3019621 caagcaaatc gcgcccttca atataggctt ttacattctc ctcatttccc ggggctaaaa 3019681 gctctctaag ctcatcgttc cctgtcagct gggctgcctg ttcaagaagc ggttttgtga 3019741 gaacggtaat ctcatagtga gaaatcagcg cttctttcag cggtcggaca tcaccttgct 3019801 tattaagcgt cacaatttct tccgggtccc aattcatttc cttaaggagc agctcgacaa 3019861 gttccggatc gttttccgga tagacgccga ggctgtcacc aggctcgtaa gtcaggccag 3019921 atccttcaag agacagctcc acatggcgtg tttctttatt tgatcctctg ccgtttaaat 3019981 ttaaattttc taacacttca gcccgaaacg ggtttgttct ggaatacgaa gactcaccgg 3020041 tttgtgacgc agccgccggc gcaggcgcgg cgcttccgcc cccagcttca tttaatcctt 3020101 tcaatacacc ctcaagccat tcggctgccg gttcatcata gtcaagatcg caatcaacgc 3020161 gcggagaaat ccgttttccg ccgagttctt ctaagcgttg atcaaattct ttccctgtct 3020221 ggcagaaaaa ttcgtacgaa ctgtcaccaa gcgccaaaac ggaaaagcgc aggtcttcaa 3020281 gcttaggcgc ccgtcttccg tgcagaaatt catgaaacga cagcgcgtta tcaggcggct 3020341 cgccttctcc atgcgtactg acgacgatta aaagattggt taccttcttc agctgattcg 3020401 gcttaaaatc gctcatggat gagacggtca cttgaaaacc gctctgttca agctgcttgc 3020461 cggcattttc tgcaagcccc tgtgcgtttc ccgtctgtga accataaaga acggtcactt 3020521 cttttgaaac ggccggtgcc ggtgcttccg ctgacacagc tgccgccggc gtacccgcag 3020581 cttcttgggc ggaaacagat tgagcggata aatatccgct cagccagatt ttctgggatt 3020641 cggtcaaggt cggcagaagg cggttaagga gctctgcctg ctcctgatta aacggactgt 3020701 tcattacctg aagttgcaac gtatccacct cacaaagtta taaactgatc gaaaattgca 3020761 tctaattgaa ctttaccgga atactaggct taagtaaaat atatttacat gatgataact 3020821 attaagaatc ctaatgataa aacggctatg cttcatgtaa atagaaaaaa gagaaggact 3020881 cccttctctt cattcagcaa tctgatataa gtgaggcggc acagcggtta caaacggact 3020941 ggcttcacct gtataaaata ccgccagcat gtgcatcgca cgggtgcacg cagtatataa 3021001 aagcctgcgg tcgtgctctg tatgatagtg ttcttcagat gcatcataga caagcactgc 3021061 gtcaaattca attcccttcg ctaaatacac cggaatcacg caaacaccct tttgaaatgg 3021121 ttgattttct ttatgaatca ggcgaacatc tgtatattca ctcatgtggg cgtgcgcctg 3021181 tatgcattga tgcgcagtct tgcagatgac ggctattgtt tcgtgccctt ttttcttgag 3021241 ccggccaatt tcttgcgcga gcttttggca aaggctctca tgtccttcag ttttgacaac 3021301 gagcggcatt tccccgcttc tattaaacgg ctcaatatcc gctccatctt gaagcatcgc 3021361 tttggtaaac tcgacaatct gccttgttga tctgtatgtt ctctttaaac gaacatactc 3021421 agcaggctca tcctcaaagc acgcatccat acgctgatcc ccgtttatgg tatgcgcgta 3021481 gatggactga ttgatatcac cgagcactgt catgctggca gccggaaaaa tgcttctcat 3021541 gtaagccatc tgaaacggtg aatagtcctg ggcttcgtca ataaatagat gtttgatttt 3021601 cgtatttttc tttctgccct caatcagatc ctgcatataa agaaacggtg ccgcgtcctc 3021661 atagagcaat ttattatccg taaatgccga acgggtcagc tcacctatcg catccatctt 3021721 ctcatgttga aattttcctc cccagccaga aaacaattgc aaataaagtt gtgtaacatc 3021781 aagaaatgca aggagcctga ctgcctgttt gagcggtttg aaagcttttt tcacaatgat 3021841 ggcggcaagc agctgctgct ctctttgata atcgttaaac gtactctcgc tgaaccgttt 3021901 cctttcctgc agttttttgt acacgtccaa gtagtcctct ttgtcaagca gctcagcttc 3021961 atgaacaacc caatcctttc gccgttcctt tttctcaagc ttgttaagct cactcagcag 3022021 ccacttcgcg gtttgctcca tccgattcgg aatggagtga ttttgatcca atgagtaaaa 3022081 ataggattga atttgctcct ttgtgatcag cttttgtccg cggaatataa tatttttaaa 3022141 aatcatccct tcagaggaaa gccgtgtgac gtattcatta atgaattgct gaaaggataa 3022201 acccgccttc catgtgattc ctgcaagcct tgttggaaaa tcgcctccct ttgtttcggt 3022261 caggcaatat tcgagctgat caaaggggct ttcacatttg aacttgcggc caagacgatg 3022321 ctcgatatat tcctgaaacg tcgcctgctc catattctct tctcctaact ccggcaaaac 3022381 agaggagaca tagctgttaa ataagaagtt gggtgaaaac aaaacgattt gtccggcatc 3022441 aatgacaccg cggtgcctgt ataacaaata agcgacacgc tgaagcgcag ccgatgtttt 3022501 cccgctgcca gccgctccct gcacgatcag gatcttgctt ttttcattac ggataatctg 3022561 attttgttct ttctgaatcg tagacacgat gtttttcatt tgggtatcag agtgatggct 3022621 taatacctct tgcagcattt catcgccaat cgtcatatcg gtattaaaca tcgccttgag 3022681 agtgccgttt ttgatcataa actggcgttt cagcaccatt tccccttcta tcgtttcacc 3022741 gggcacctcg tactccgctt ttcctgggga ataattgtag tacaaacttg atatcggcgc 3022801 cctccagtca tagatcagaa agtgttcctc cttctcatcc aaacaggaag ctaaaccgat 3022861 ataaattcgc tctgcctgct cctcgccgtt ttcaataaaa tcaatccggc cgaaataagg 3022921 cgattttttc aattgatgaa ttcgtttgag ctgctgatcc atgcgccgat gattgtgttc 3022981 ccgatcagac agcagctctg cctgctgctt aatgctagcc atcgtttcaa tcgcttcatg 3023041 ggcatcatca aaattaacct taacatcctc ccaaaagctt tttcttaatc cgatgatatc 3023101 atgcttcaac ccgcccgcag acgtttccag aaaccgctct tttttttcga gctccttcag 3023161 cacctcatct attctcgact gctcttcctt ccattcctta tcctgctgat tcatgaacgg 3023221 cacctccaga aaatagttga caaacataga tgaaatactg taaaatataa ttggatacat 3023281 atattaaata tatgatgcaa actggcaaat acaatttata atagcacatt cacccaatac 3023341 caatcaaggt ttgggttatt tatattatgc agaaaaaaac cgatttcact tcgaaatcgg 3023401 tttttttgct attaattatc taagcgaaaa gaacggtttg gcagcttcca attaaacata 3023461 taggaacaaa cccggcaaac aacgagcacg aaaaacagaa cgtataagcc gaacgagttc 3023521 cccagccagc ccaagccgac gattaaaccg ccgagcgccg cccataccgc atagatttcc 3023581 gctttcagca caagcggttt gcgcccggca agaaggtcgc ggatgatccc gcccccgctt 3023641 cccgtcagca ccgcagccac gatcacggca ctaagcggat ggcccatttt gacggcatac 3023701 agtgcgcctt ggatagcaaa ggcagcgagg ccgatcgcat ctgataaatt gccccactta 3023761 ttccaatgct tcagcagcag cttcggaaac agaaacacaa ttgtaataga taaaagcgcg 3023821 atttgaaagt acgctccctg ctcccatagc gctgacaccg gaacaccgat cagcaaattg 3023881 cggatcgctc ctcctccaaa agctgtgaca atccctaata tataaactcc taaaatatca 3023941 tattcctctt ccatcgcaac aattgcgccg ctgactgcaa acgcaatgat gccaatcaca 3024001 ctaagcagct cccaagccat tctgatgact cccttttatg tttgttaaat tttctgacga 3024061 cctctagatt ttataatcgc tccagcgtaa aatcaataac attttcatga gaaaaaaaga 3024121 taaatttaga gggaatacgg ctattgctga tggacatgag tttgcgaaat taaaaaagcg 3024181 cccggcatac gcgggcgctt tttttgttat tcagattttt cgcctttcag caggcacata 3024241 aaaatgataa tcaggataaa agcaatcagg gccaggaatg gaatcgtaat aaaaccaaac 3024301 cagttaatat attggcccga gcacggcacg ccgctgacac atggcttaat gccgctaaag 3024361 ccgggcactt tttgctctaa gtaatgcatg atcgaaatga atgccccaat aatcgccatc 3024421 gggagcacat attttttcac tcgtgtgtcc ccttgaaagg tggcgatgcc taaaatcagg 3024481 acgagcggat acatgaggat acgctggtac cagcacagtt cacatggaat aaactttctg 3024541 atttcactga aatacaggct gcccagcata gcgataagag ccacaaccca ggaagcatat 3024601 aaaaatacga ttctattttt catattgtta cttccctttc agctcttttt ctattgtctc 3024661 tttgatttca tcataatccg caaaattttt gatcacttta tcattgacgt aaatcgtcgg 3024721 tgttgcctgt atgttcattt tttgattaag gtcagaatcc ttttccactt gagaagcgaa 3024781 tgtttcctta tcaagatttt ccttgagcgt ctcaggtttt atctttgtgg tgctttttgc 3024841 aagatcacca aggaggcctg gggttaccca ttcctgttcc gtatccggct gtttttcgaa 3024901 cagcttttca tggaaatccc agaaagagtc agggtcttcc ttccatactt cttcagatgc 3024961 aagagccgct aaccttgaac cttttccatg gaacatgacg ttcacgaaag aaaatttcac 3025021 atcgccctta tcaataaagt ctttttgtat ttttggaaag atgtcactgt taaacacctt 3025081 gcaagacgga catttgtaat ctccgaattc tactacagtt accggtgcat cgtccttgcc 3025141 aagcacaggc tgccctttga tagacggctg tccggacacc gcatcattgc cttgttccgt 3025201 tttgttatta atgatgacaa tggctgctag caatacaaca accacaaccg taaggatgac 3025261 cgcgaatttc gcagaagact gctgtttctt tttcactccg acacctcatc gttttaaaat 3025321 taaaaaagaa gcggatcgca attgacccac ttctttattt taacaagaca agcgctgata 3025381 agaaaacccc gaaaaaatga attctctccg acaatttatt tgtttttgag acgcatgacg 3025441 cgcatggcgt tcgccacagc aagcagtgta acgccgacat ctgagaaaac cgcttcccac 3025501 atggtcgcaa ttccaaatgc accaagaatg agaaagatcg ctttcacacc taaagcaaag 3025561 ccgatgtttt gccacacgat tcgccgtgtc cgtttcgcaa tccgaatcgc ttctgctatt 3025621 tttgacggct gatctgtcat cagcacgatg tctgcggctt ctaccgcggc gtctgagcca 3025681 aggcctccca tcgcaacccc tatatctgcg cgtgcaagca ccggcgtatc attgatgccg 3025741 tcaccgacaa aaatgagttt ttcactaggc aaaagcttag cttctaatgc ttcgacctgc 3025801 gcgactttat cttgcggcag cagctctgca tatacctcac caatcccaag ctgttttccg 3025861 acggcttctc ccgtttgttt cgaatcaccc gtcagcatag ctgtctgttt gatcccaagc 3025921 gacttcagat cagcaaccgc ctgtgctgcg tcttccttta tctcatccgc tatgatgatt 3025981 gctccggcat agcgttgatc tacagcaacg tgtacgattg ttccagcatt ttcatccggg 3026041 acatcctcaa tttgttctct ttccatgagc tttttattcc cagcaaggat ctcagttcca 3026101 tttacctttg caaaaatgcc gtgaccggag atttcttcgt atgactcaat ctcatcggag 3026161 gaaagcattt tcccgtaagc tttacgcaca gattcagcaa tcggatgctg tgaatgaagc 3026221 tcagcgtatg ccgccgcttc aagtaatcta tcctttgtaa aaccttccgc gggtttgatt 3026281 tctgtcactt caaagctgcc ttttgttagt gttcccgttt tatcaaacac cgcgtatttg 3026341 acttgattca aagcttctaa ataattgctt ccctttacaa gcactccggc ctttgaggcc 3026401 gctccgattc caccgaagaa accgagcgga atagagacaa caagcgcaca aggacaagaa 3026461 atcactaaaa agataagcgc gcggtacacc caatcggaaa gcgcggcgcc agaaagaaca 3026521 agcggcggaa caaaggccag caataccgca atgatcacca cagcaggtgt ataatacttg 3026581 gcaaacttcg tgataaagtt ttctgtccgg gctttacggc tgctcgcatt ctgaaccaag 3026641 tctaatattt ttgatactgc tgattcctga tagccctttg tgacttcaat atgcagaacg 3026701 ccgttttgat tgataaagcc tgacattaca tcttgtcctt ccgcagcttt tctcggaacg 3026761 gactcacctg ttaaagcaga tgtatcaacc atcgctgacc cttgcacgac cttaccgtcc 3026821 aggggtatgc tttctcccgg attaaccaca atgatgtctc ctgtctgaac gtcctccgac 3026881 gaaacctgtt cgatgccgtt ctttgttttg agattggcgt aatcaggccg tatgtccatt 3026941 aacgcactaa ttgattttct ggaacggctg accgcggctc cttgaaaaag ctcaccgatt 3027001 tgataaaaca gcataacggc gaccccctca gggtattgct gaatcagaaa agcgccgatt 3027061 gtggcaagag ccattaagaa atgctcatca aacacctgac cgcggatgat gtttttgact 3027121 gcgcggatta taatgtcacc gccgataatc aaataagcac cgaggaaaag gaaaaattca 3027181 atggttcccg actgaaccaa atatgccgct gcgccgagaa tgacagccgc cgccattctg 3027241 atcagcatat tgaccattcg attacgatag ccatcatcag ctgatttctt tatatgcttt 3027301 tggcgaaccg ttacatgcgg atcaattgat ttcacttttt tctctacttt attcgtgacc 3027361 cattgctctt ctttcccatc ggctgagaca gttaaggtgc ttgccgcaaa atttaccgcg 3027421 catccgttaa tgccttttat gcctttgact ccattttcga tttttcgggc acaattgctg 3027481 caatccaaac cgtccagaac atattcctgt ttcactagtc tcaccttacc ttccgattta 3027541 gggttccctc ttcaaagcgt atcaatgagt attgtattta ttttatatat atgagcatat 3027601 actcatatat aagttacacc tattatatgt tgttttccaa gaaagtgtca atgaaaaaca 3027661 aaaaccggca tatagccggt ttttcatttt actttttgca gacgaagagc attcagaaca 3027721 acggaaacgg agctgaatgc cattgctgct cctgctatcc acggtgctaa aaatccaagt 3027781 gctgcgattg ggatgccgag gctgttatag ccaagcgccc agaataagtt ttgtttaatg 3027841 tttttcattg tcaatctgct catgcggatt gcgtcggcaa tgctgttcag atcgccgcga 3027901 ataagtgtaa tgtctgctgt ttccatggca atgtccgtgc cagttccaat cgccatgccg 3027961 atgtcagctg tggcaagcgc cggcgcatcg ttaattccgt cgcctaccat tgctgtctgg 3028021 cggccttctt tttgcaagcg ggcgatttcc gccgcctttt gttcaggaag aacttccgca 3028081 atgatattcg caattcccgc ttccttcgcg atggcttctg cggttctgcg attgtctcct 3028141 gtcatcatga tgacatcaag acccaactct ttcagacggg caacagcctt ccgcgacgta 3028201 tccttaatcg tatctgcaac tgctactagc cccgctgctt ctccatcaat ggatacaagc 3028261 ataactgttt tcccttcggc ctctagctct tccatttggg cgagaagagc cccatgctca 3028321 acctgttcgc tctccattaa ttttcttgtg ccgacgagaa tgctttttcc tccggcttca 3028381 gccaaaatgc ctgcgccgac ttttgcttca aagcgggtaa gtttcggtat ctcaagccct 3028441 ttatctttca cgccagcaat aatcgcttcg ccaagcggat gctctgatcc cgtttccgct 3028501 gccgctgcaa attgaagcaa atctttttct tcaaaacggc cgaatggaat ggcatccgtc 3028561 agacgcggct tcccgtttgt cacggttccg gttttatcaa gaacaattgt atcgagacga 3028621 tgtgtttttt ctaaatgctc gccgccttta aataaaatcc cgaattcagc agcgcgtcca 3028681 gatccagcca ttatgctcgt cggagtggca agaccgaggg cgcaaggaca ggcaatgaca 3028741 agaaccgcaa tgaacttgct gatcgcttcg gcaaaatcgc caggagccgc ccaaagatac 3028801 caaatgagaa aagtgagaac cgcaatcccc aatacaatgg gtacaaaaat gcctgaaatc 3028861 tggtcagcga gacgctggat cggcgctttt gacccttgtg cttcctcaac aattttgatg 3028921 atatgagaaa gcgcagtatc ctttccgacg ttgacagctt taattttcag aaagccgttt 3028981 gcgttaacgg ttgaacctgt cacgctgtca ccaggatttt tgtcaacagg aagactttct 3029041 cctgtaatca tcgattcgtc aaccgctgaa cggccttcaa ccacttctcc gtcgacagga 3029101 attcgttcgc caggtttgac gtaaacaatg tcattaacaa gcacttcgtc gatcgggatg 3029161 atttgctcct gtccgtctct tacaacagta gctgttttcg cttgaagctt catcagcttt 3029221 ttaatcgcat ccgaggaacg gccttttgct tttgtttcaa acaacttgcc taataaaatc 3029281 agcgtcagca aaatcgcgct tgtttcataa taaaggccgt ctgtatgccc gtgagagcca 3029341 atgctttgaa aagttagata aagactataa gcgtaagcag ccgtcgtacc gagggcgacc 3029401 aatacatcca tattggcgct tttatttcta agcgccttat acgcacccac ataaaacggc 3029461 cagccgatca gaaactggac tggtgtcgcc agcgcaaact gcatccacgg attgagaaat 3029521 atatccggta cccaaatgaa tgatgtaaat gtaaaatggc tcaccatcgc ccaaagcaat 3029581 ggaaatgaca ggacagctga aaaaatcagt ctcgccgttt gcttccgttc ttctttcttt 3029641 ttagcagcag cctcactgtc ctgttcaccc ttcaacttta gcttatatcc aagcttatct 3029701 accgcttctt tcaaatcgct gacagacgct tcttttggat tgtattcgac cgtaactgtt 3029761 tctaaagcga agtttactgg tgcatttgcg acgccttcta ttttgttaag ccgtttttca 3029821 atccgattgg cgcaagccgc acaggtcatg ccctcaatat cgaattcagc tttttctgta 3029881 acgacgtgat agcccagctt ctctattttt tcctgaatcg ctgcagtccc tgtttcagca 3029941 ggatcgtaga ttacatttga tgtttccgtt gccagattaa catttgcatc cgtgacaccg 3030001 ggcatccgct tcaggccttt ttcaattctg gcagcacatg ccgcacaggt cataccagag 3030061 acctgcatcg cgatttcctt ttgttcactc aacatactca ctcctttata tacacctggg 3030121 gggtatataa aaatgaaaga aatatcgcgc ctccctaaag gcgcgatacc ttgaatcact 3030181 tggctacgtc atagccctga tcttctatcg catccgcaat atctttgact gatactttgt 3030241 cagcatcaaa cgaaacatcg actttacccg cttccagatt gacatgaacg gcactgacgc 3030301 cgtccagttc tcctacgctt gtttctactg ctttgacgca gtgctgacaa gacattcctt 3030361 caacttgcaa tgttttttgt tccatatcaa ttcctcctgt ttattctttc tattttcatc 3030421 ctaccatacc cccgtagggt attacaataa aaaacgcttt atgattttgt gaacttttta 3030481 aatacgtcca aaagctcaga aatggcctgt tccccgtctc cgcttttgat ggcatctgct 3030541 acacaatgat gggcatgatc ctcaagcaaa tgaagcgcca catttttcat tgccgcctga 3030601 acagctgaaa tttgcacaag aatatctaca caatatctgt cgttttccac catgttttga 3030661 atgcctctga cctggccctc aatccgctta agccggtttg taatctgatc cttttctttc 3030721 gagcttttat ggtttaatgt tttatgttcg ttatgctttt ccatgcgtac acctctgttt 3030781 aatgatatta attcccatta tactgattgt ccaaacggtt gtctaagcat gccgacgcaa 3030841 aaaatgaatc agttaggttt taccatttga tcaggagggt atatacttct gttgataacg 3030901 cttttaaagg ggagaagaaa agtggatacg atcaaggttg gaatattagg atacggattg 3030961 tccggttctg tttttcacgg gccgctgctg gatgttctgg atgaatatca aatcagcaaa 3031021 atcatgacat cacggacaga agaagtgaaa cgggattttc cagatgctga ggttgtacat 3031081 gagcttgaag aaatcacaaa tgaccctgcc attgagcttg tcattgtcac caccccgagc 3031141 ggccttcatt acgagcatac tatggcatgc atacaggccg gaaaacatgt tgtgatggaa 3031201 aaaccaatga cagcaacggc cgaagagggg gaaacattaa aaagggctgc cgatgaaaaa 3031261 ggcgtattat taagcgtata tcataaccga cgctgggata acgatttttt aacgattaaa 3031321 aagctgatct ctgagggatc ccttgaagat atcaatacat atcaagtttc ctataaccgc 3031381 tacagacctg aagttcaagc gcggtggcgg gaaaaagaag gcactgccac tggtacgctg 3031441 tatgatctcg gctcccacat catagaccaa accctgcatt tgtttgggat gcctaaagcc 3031501 gtgactgcaa acgtgatggc ccagcgggaa aatgccgaaa cggttgacta ttttcattta 3031561 accctggatt atggcaagct tcaagccatt ctatacggag gatcaatcgt tccggcaaac 3031621 ggacctcgtt atcaaatcca tggaaaagat tctagcttta tcaaatatgg aattgacgga 3031681 caggaagacg cactcagagc gggaagaaaa ccagaggatg acagctgggg tgcggatgtt 3031741 ccggagtttt acggaaagct tacaaccatt cgtggctccg acaaaaaaac agaaacgatt 3031801 ccatcagtaa atggctccta ccttacttat taccgtaaaa tagcggaaag catacgagaa 3031861 ggtgctgcgc tgccagtcac tgctgaggaa ggtattaatg tcatccgcat cattgaagcc 3031921 gcgatggaaa gcagtaaaga gaaacgaacc attatgctgg agcactaaaa caaaagcctc 3031981 cccaaataag gggaggcttt ttcattagaa tgtttttcct gcttctttcg cacgcgcaat 3032041 cgcgtcttct ttgatttgct gtgctttatc aggctccgca ttatgtccct ctacgaaaat 3032101 gccatcgaat gatggtacgc cgaagaagtt catcatgatg ccgatgtagc ggtgccccat 3032161 ttccatctca gccgcagggc cttctgaata gtagccgccg cgcgcttgga tatgaattgc 3032221 ttttttatca gttaacaagc cgacaggacc ttgttctgtg tatttgaatg attttcctgc 3032281 aacagcaaca gaatcgagat acgctttcat cactggcggg aatgagaagt tccataaagg 3032341 agtaacaaat acgtacttat cagctgatgc aaattgatcg ctaagctctc ccaaacggcc 3032401 tactttcgct ttttcgcttt cagaaagctc ttcaaagcct gtacctgact gaagctttcc 3032461 ccatccgcta aatacatctg cgtcaatgtg cggaatgttt tctttgtaca aatcgatatg 3032521 tacaacttca tcatttggat tcgcttcttt gtaagattcg ataaatgctt tacctgttgc 3032581 catactgtac gaagttgctt cgtcatgtgg atgagcagtg atatataata cttttgccat 3032641 ttttaccagc cctttcgttt ttaaaaatca cacatcaatt attatcatac agatgcataa 3032701 tgattattct gtctctctta gactttatta tagagacaaa gaaatttact ttcaagtaaa 3032761 acatctcgaa ttaaagatta tttaactttc ccaaacagct tacttttcaa aagctgttct 3032821 caagccggaa tacagcgcgg acaattcttt actgatccga ggataatgag ggacatgcgg 3032881 cacttgaata tccgcaggca tccttttcat gataaaggat tgctcagcct gttcaaaaaa 3032941 cgcccgcagc tggttgatct cttcatcaga aaacggagca gacggacggc ggtgagcttg 3033001 cgccgagagc aaatagtacc ctaagtgctg agcaccggaa atggcaggcc agagcgcatc 3033061 cgcattcgcg tgaggaaact cgccaagcgc cttgtcatac gcatcccgaa gcctgacaag 3033121 actcaccctt aacttgtgtt cgtcggcaat ttgcccggtt aacagtttct ccataaactg 3033181 cccttccagc cggatgacat tccgcacaag ttctggcagc cgcttggttg aaaaccgccg 3033241 ccacaaaagc attgttccca acagcccgat cacgctgccg acagctacat cagtcagcct 3033301 cgctatcata aaataaccgg cgcccgcccc gccatgcata ctttctgtga taacaagcgc 3033361 atttgcggtt aaaaagggaa cagccagcgc ataattgcgg acgatcagca tctcaagaag 3033421 acattgcagc gctgcaatac aaaacgcaat ataaacaccg cccggcttaa aaaacaggat 3033481 tgcgcctgcc agtataacac cgatcaccgt tccggccgaa cgctgaatag ccctgtgaag 3033541 cgtaaaaaca acagtagtgc caagcatgac cgctgctgcc gaaagcggaa tccaatagga 3033601 gcgtgcaaag ccgaatgcga gggcaaacat atcggcggca aacagaacaa ttccgtactt 3033661 taacgctcta atcaaaactg gagacttcca gtcaaaggca tttctcaaaa agtaaaaaga 3033721 ggatggcagg cggcttggtt ccccgtcaag ctgcttatca aaacgtcctg aagcgatata 3033781 caaaacctca ttgatttctt caaacagctt ccgcctaggc tcagattcat tttcattaat 3033841 ctgaaacgta ttgaaaaccc gtgcattcgc aagcatatct ccggtttggc gaagtgcctt 3033901 ttcaatctgc gcggtctctc tgtccggcgt ttcagctgaa aaatgaataa tggcaataaa 3033961 tatgtcgtca gctttctcaa ggaggcgaaa aaatcgttca tcatgccgcg attttttccg 3034021 tctgttccct ttcccaagaa ccgtttggcg ggctgttcta agcatgagca ccgtctgatg 3034081 ctgtgcgtta tgaaaacctg gcgttccgac ggctgaaaga catgcagcca gctgatgata 3034141 tgttttttgc agcaccgctc cctccggtcc atgtttgttc cataaccagc cgattaaagc 3034201 gatacccatg gcgaaaatgc cgccgagaaa cgtcagtccc gctctgaaca gcgcttgtga 3034261 aggatcggcc ggcagcccgg aactgactaa aaaggcaagg acaaaaaaca tcggcgcagg 3034321 gccttgaatg ccgagcgcgc taaaaataaa catcgccgct gcaccgatca gccccaaaac 3034381 agccgccatc atccaaagca tcccggacaa aagcgtccct aaaccaaatg agagggcgat 3034441 cccaatagaa accaagagca gcttcaaggc gcgctttttg tacgattcac cgcccgcata 3034501 taaataaaca aagcctccga tacttgcaat taatccgtaa tccgtgtgac ctgccaatgc 3034561 accgaccagc acaggaaacc ctgaagcgaa acctgatccg atagcctttt tccaaggaaa 3034621 tggatttgca tgaatgcgaa aggcatcctt cacgataggc atgattcttt gattgttcgc 3034681 agcagttttg ttcatttgac aaaatccttt tcaatgaatg tgtagaactt ttccagtttc 3034741 ttcgctttag tatgcccaaa aacgcggtta gcttctcaat tggtgcgcac gataaaaaaa 3034801 cagagactta taccgtctct gcttcattac atcagtttat tataaaagcg gcacctgtca 3034861 ggactgtttt gtccttctgc cttccttcaa gagcaggtga ataaaaaata aaggataaat 3034921 caatagatac ccattaaaca gccaccacac aagatcaaag tcactgctga atgtccagaa 3034981 tgatagcgcc tgcagacctg aacaacaggt cagcacaaga gaaatcagcg ccatcagctt 3035041 ccagtcagca cgattcaccc gctgtaggta caagctgtac aaccctgtga cagaaatcag 3035101 gatatccagc ggaaaaaaag accagttcca agcgatcata aacggatggt catgatgttt 3035161 aaaagcccag ctttccggta tgagcgaaaa tccggctgac agccagtaca agataaaacc 3035221 gatatcagtc acgagaaaaa acagcttcat atatctcatt tgtactgccc gcttttatgt 3035281 accggctcag acaccgcaac atgctcgatc aggtttaaag acacaacacc ggcaataatc 3035341 aatccaattg aaatgacttt catgacactc acatgttctt gaaaaaacaa aaaaccaacg 3035401 actgtaatca agacaattcc catccctgac catacagcat aagcaactga tacatcaatg 3035461 gatttaagcg taagcgtcag aaagaaaaga ctccctccat aaaagaaaat caacagcaaa 3035521 ctgggaataa gctttgtaaa accagacgat agcttcatgc tgacagttcc cgcaacctca 3035581 aacaaaatcg ccaagcatag aaacacccaa ttcatgtggc atcagcctcc tcatcagctg 3035641 ttataccgtt aaacaaaaca tctacaattg attcaagtac ctctcctgtc gtgaactgat 3035701 gtttcagcgg atattcaggg tcatacactt gattgatgct ccctatatac atgtgaacaa 3035761 acaggtccgg attgatgttt ctgattctct tttgctgttt gcactcattt aataatgcta 3035821 ggacaatcgc ccattcttcc ttaataaacg cgtctaatgt aagccacgca tcgtaatggt 3035881 atttctttag ttcatttaat aatcccatgt tcagcagttc catcccctgc ggaaggctga 3035941 tcagcatttg tttcaccttt tcgagcacat ttaaactttc attttcatag atgtctcttt 3036001 ctatttgctt catttcagct ataaattgtt cgacaaccgc ctcaacaagc tgatctttag 3036061 atgaataata tgcatagagc gtccgcttgc tcgttcccag cgctgccgcc aaatcattca 3036121 tcgtaaatga aaatcctttc tgcttgatca gccggaaggt ttccgccaga attcttttat 3036181 ccatattaat cccccgcttt cggtaccaag aaaactattt cggtaccaat attatacggc 3036241 agaaatttat ggaaatcaac aatatataaa aaaacctctc ctattgggag aggtttaaaa 3036301 gacactgcgg accaaaccgc cgtccgcccg aagtgccgcg ccattgatcg cagaggaaag 3036361 cggactgctt aaaaatgtaa cgaagtgggc gatttcttcc ggacggatca gtctttgaat 3036421 aatagatgtc ggccggtttt ctttcataaa acgtgcctca gcttcttgaa cagtcaggtt 3036481 ttcaccagga tacagcgagt tcagcatggt ttccacaccc tctgttaagg tagagcccgg 3036541 catgacggtg ttgactgtga cattcgtgcc ggttgccagc tccgccaaac tgcgggaaat 3036601 ggacagctgc atcgtttttg tcgcactgta atgggccatt tcctgtgacg gcataatcgc 3036661 cgcttcactg gcaatgaaaa tcacacgccc ttcttttttc tctatcatgt tatgcaaata 3036721 cctgcgtgtc agccttacac cgctcataat attcacttca aaaaaacgaa accattcatc 3036781 gtcgggaata tcaaagtact ccgccggttc aaaaatccct aaattgttga ccaaaatatc 3036841 aacctctgga tatgcctgaa acagctcatt gcagccttct tctgttccca aatcaaatgc 3036901 agccggataa agaaccgctt cagcatgttg tgttttcagt tcatctatcg tttgattcac 3036961 tttctcttcc cggcgtccgt taatgatcac tgccgcacct tcttcagcta acgaagaggc 3037021 aatagctttt ccgatccctg atgtcgaacc ggtcaccagt gcggtttttc cttgtaaatt 3037081 cagcttcatt attcatccct ccgtttttga ttcctcttat ttattgacag aaatctgatt 3037141 ggtgaaacat ctgctctgca atcagtatga aacagctggg attgaaatgg aagtacgcac 3037201 tttttggtgc ctgtggtttg gagaaaaaat aaagcagaac ctcttaagag gttctgcttt 3037261 attgtcagta tgtatggaga cggtgggagt cgaacccacg tccagaaaca tcgattactt 3037321 aagcgtctac gagcgtagcc tgcatattta tggtttcact catcttcttg cctgcgggcg 3037381 ggccttccga gagctagtct gttcatctct tcttacgttc tcagacggga acgcaagcgt 3037441 agcctacttg gatgtgctct tcacagacac ataggcaatg tcaggaagag ctcgctgcgc 3037501 ttattaggca gctaatgcta cgttttggtt aaaactgtta gttttgccag ttatatttaa 3037561 gtgcgtgttt acgagatcgc ctctcggctc gcagctcaag ctcgatccat ccctgtcgaa 3037621 tccgtaacgt ccccttggta taagggaaat acgggagaaa atatcaagct ctcactcaaa 3037681 ctggctatag tcttattata acatgatcac ggctcttttc aattgtcaaa tccttcaaat 3037741 gaatggcgtc gtgatctgat cgtgaacaca gtatagcaca ggcctgattt tcgaatcaag 3037801 cactatgcct ttagaagcct ttttgactgt ctctgaacgc tctttcgatt tcccgcttcg 3037861 cgtccttgcg cttcagatct tcccgtttgt catagttctt cttccctttt ccaaggccga 3037921 gaagcacttt ggcaaagccg ttttttaaat acagcttcag cggaacgaga gaatagcctt 3037981 tttcctttgt taacccgatc agcttattaa tctccttgcg gtgcattaac agctttcttg 3038041 tccggagcgg atcgtggtta tagcggtttc cctgctcata tgggctgacg tgcatattgt 3038101 ggagaaacac ttctccccgt tcgattttgg cgaaggaatc cttaaggttt acgcggccgg 3038161 cgcgaatcga tttgatttcg gttccttgca gaacgatgcc tgtttcatag gtttcttcta 3038221 taaaataatc gtggttggct ttcttatttt gagataatac ttttcctgac ccttttggca 3038281 tgccagaacc tcctctctct aaggaaaaac tgtccacctt ttgcgatacg ctctatttta 3038341 ccaaatgtca cgtaccgcta caatgaaaag ctgtttccga aagaaagcaa atagagcgct 3038401 gcggccctat ttgctggttg agctgctatt tcttcttttt ccgtttctgt ttcggagcat 3038461 tctggaagcc gcgttttttc tttttcttct tcggcttagt gaaccactcc cctttttcct 3038521 cagacggagc tggagaaaca ggtgtattgg tgctttgaac acgttttctg gcaggctttc 3038581 cgcgttttct gctccggctg ctgtccaatt ctctcggacg ccgcggagtg cctttcatgc 3038641 cgacaatttc aaagtcgata ttgcgctcat ctttattgac atcgacaacc ttgactgtga 3038701 tttcatcccc gatgcggaag acgttgcctg tccgctcgcc aatcattgcg aaatgctgtt 3038761 cgtcaaagcg gtagtagtca tctgtcataa agctgacatg gacgagtcct tcaattgtat 3038821 tcggcagctc gacgaacatt ccgaagtttg tcacagagct gatcatgccg tcaaactctt 3038881 caccgatttt atcaagcatg tattccgctt ttttcagatc atccgtctca cgctcggcgt 3038941 caactgcacg gcgctccata gatgatgtat gttcggcgat atccggcagg cgttcagccc 3039001 acttttcctg tgtcgcttca tcgaccttgc cgttgatcaa atacgttcgg atcagacggt 3039061 gaacgattaa gtccgggtaa cggcggatcg gtgatgtgaa atgcgtatag aattccgttg 3039121 acagaccgaa gtgccccaag ctttgcgggt cgtatttcgc ctgtttcatc gaacggagca 3039181 taacagtaga tataaccgtt tcctctggtc tgtcacgcac agcgtccaga atgctttgca 3039241 gcgcgcgcgg atgaatattc cccgccgttc ctttcaccac atagccaaat gtcgtcacaa 3039301 attctaaaaa cttttgcagc ttttcagcat tcggctcttc gtgaatccgg tatataaacg 3039361 ggacattcat ccaatggaaa tgctccgcaa ctgtttcgtt tgctacaagc ataaattctt 3039421 caatcagctt ctcggcgaca gagcgttctc tgatcacaac gtctttaacc gctccttcgt 3039481 catcaacaag cacctttgct tctttgaaat caaagtcaac ggcgccgcgg tccatccgct 3039541 tatcgcgcag aatttgagcc agacgctcca tgtctttgaa catcggaaca agaggctcgt 3039601 atttttgttt cagctcttca tcatcatcaa caagaatttt attcacatct gaatatgtca 3039661 ttctttccgt tgttttgatg acactttgga agatctcgtg ctctgtcacc tgtccctgac 3039721 tgttaattgt catttcacaa gaaagcgtca ggcggtcaac ctttggattt aaggagcaga 3039781 tgccgtttga caatctgtgc ggaatcatcg ggatgacacg gtcaaccaga tacacacttg 3039841 tccctctttc aagcgcttct ttgtcaatcg gcgagttttc ggttacgtaa tggctgacat 3039901 cagctatgtg aacgccaagc ttgtagcttc catcatcaag cttcgtcacg gtaactgcat 3039961 catccaaatc cttcgcatcc gcaccatcaa tggtgacaat cacctggtca cggagatcac 3040021 ggcggtcttt cagatctttt tcatcaatcg tgtcaggcgt acttgatgcc tgttccatcg 3040081 cgtcagctgg aaattctccc ggcaggccgt gcttatgaat gaccgataaa atatcaatgc 3040141 ccgggtcgtt tttgtggccg agaatggttt caacctcacc ctctgcgttc atgcggcctt 3040201 caggatagct cgtcagcttg acaacaacct tatgcccttc cgcagctcca tttttcccat 3040261 ttttcggaat gaagatgtca ctcgtgattt ttttgtcgtc cggaatgaca aagccgaagt 3040321 ttctcgtttc tgtatacgtg ccgacaaccc gctgaatcgc tctttctaaa atccgtatga 3040381 cggttccttc ctgcctggag ccgcttgatt gtgagttcag acgcaccatg acgatatcgc 3040441 cgttcattgc cgtatttagc tcattaggcg gaataaacac atcacttaac gacgtatcct 3040501 caggcagcaa aaaggcgaat cctttcgcat gggctgaaat ctttcctttt attaaattca 3040561 tcttctccgg aatgccgtag cggtcgcttc tcgtccgtac gataagccct ttttcttcca 3040621 aggcgactaa cgctttgacg agctctttaa actcctcggc ttccgtaata tttaacatct 3040681 cctcaagttc ctgaacggtc agaggtttgt acgcctcttc cttcataaac gagagaagct 3040741 tttccataaa tgcttctttt tccattatcc gacctcctgt tgattaccaa tcgagcttct 3040801 ctaaaaattc atacacatcc tgatggacga ggtcacgttc tttgtcgagt gtaatgacat 3040861 gccctgattc ctcgtaccat ttcagctgtt tatcatcagt ttccacttcg ttgtaaataa 3040921 tattggcgct ttcggtatta atcatgtggt catgacgggc ctgcaccaca aatgtcggtg 3040981 aataaatcat atcgacatta ttccgcacat cagcaattaa gtcttgcagc gccttgaggg 3041041 tattcatcgg cgttttttcg aattctttca tttcctcttc aatttgctcc gggcttttcc 3041101 cctcaaactt tttgtaattg cgagcgtatg aaagaacgcc ttgatacatg acctcttcac 3041161 tcttaatatg catcggtgcg cacattggga caattccctt tatgggtaca gtgtaaccca 3041221 atttcagcga aaaaaccccg ccaagcgaca gtccgcaggc agcaatgctc tcataacctt 3041281 cagattttaa atattcatag ccatccatta cgtttttcca ccagtcttcg ggccccgtat 3041341 gtacaagttc ttcaggcggg acgccatgtc cttcatattg aggcgcgtgg cacgtatagc 3041401 cgcgttcatt caaatatcgt cccagcatcc ttacatccgc tgtatttcct gtaaagccat 3041461 gcagcaaaag caccgctttg tctccgcctt taaatgtaaa tggttttggt gtcacaactt 3041521 tcatgctcat gtctcccttt ctatctgcac gatcatttta gttttccaca gtttaatcag 3041581 aaaaaaacgt tttgaatatc atccagaaac gtgaaaaagg cctgacttca catcagacct 3041641 tatacaaaca ttgccctata ggatataagc aagcgcaatc gttaacacga aaaacaagac 3041701 tgccagcact accgtaatgc ggtgcaaaat taaatcaaga cctcttgctt tttgtttccc 3041761 gaagagctgc tccgctccgc ctgaaatcgc accagataat ccggcacttt tactggattg 3041821 aagcaaaacg acaataataa gtgcaatgct gacgataacc aataaggtaa tcaaaactgc 3041881 gtgcatccca tacacctcca gactcactgg ctacattact tctattttac atgaaaaggg 3041941 ttggcatgtc acgctgtatc agacgccaaa aggccggata agacgtttta tcttggttac 3042001 cctattcata tgaaaaggtc aaaggagaaa agcgatgccg cttatcagca tagacagcag 3042061 gaaacatctt ttttatgaag aatatggaca gggaatccct atcattttta tccacccgcc 3042121 gggcatggga cgaaaggttt tttattatca gcgccttcta tccaagcatt tcagggtgat 3042181 ttttccggat ttaagtggcc acggtgatag tgatcacatc gatcagccag cgtctatttc 3042241 ctattacgca aacgagatcg cgcaattcat ggacgctttg cacattgata aagctgtgtt 3042301 attcgggtat tctgccggag gcttaatcgc gcagcatatc ggcttcaccc gcccggacaa 3042361 agtgtcacac cttattctgt ccggcgccta ccccgctgtt cataacgtaa tcggccagaa 3042421 gctgcacaaa ctgggaatgt atctgcttga aaaaaacccc ggtttgctca tgaaaatcct 3042481 cgctggcagc cacacaaaag acagacagct tcgcagcata ttaacagacc atatgaaaaa 3042541 agcagaccag gcccattggc atcagtatta tctggattcg cttggctaca actgcattga 3042601 acagctgccc cgcctagaaa tgccaatgct gtttatgtat ggcggcctgc gggactggac 3042661 ctttacaaac gcaggctatt accgaagatc gtgcagacat gccgaatttt tcagattgga 3042721 atatcaggga catcaattgc cgacaaaaca atggaaaacg tgcaatgagc tggtgacagg 3042781 gtttgtgctg acacatcatt cataggaata gaaaacgctt ggcttccttg cgttttttgt 3042841 tactttattg acttttgtca acgaaatcat agtaaaaaag atcctcaaat ttcaaattaa 3042901 aatagtgaag cattttacca atcacaagct gccccggcct tctttctcca ttcagcacgc 3042961 ggctcagtgt ggcgggtgag actccgattt ccagcgcaag ctgattaagg gaataatcgt 3043021 tattaaccat atactgcaag acataatcac gtctaatctg tatcttttct actggcactt 3043081 tcctcacctt ccattcctga aaaacttttt tctatacttt tacattacgg cttatgttaa 3043141 cttttgtcaa tacatttcca gtctacctat tccctttagt caataaacat actaaaatat 3043201 gagtaacagt gagggacggg gtgagatata tggaaagctt tggcgaacaa ttacgggcat 3043261 tgcgtgaaga gagaaagtta acagtcaacc agctggcgac ttattcaggc gtaagcgcgg 3043321 ccggcatctc cagaatcgaa aacggaaaac ggggcgttcc caaacctgcc accatcaaaa 3043381 aactggcaga ggccttaaaa attccttatg aggggcttat gtacaaggct ggttacatcg 3043441 aagaagtgca tgaagccagg gccccttatg aaacgaagtg caagctgctt gaaaaagcgg 3043501 aggcctatga cctgaaaaac cttgcgcttc ttgagaacga aaagtggcaa tatctcaata 3043561 aagaagattt gctcatgctg gatcattatt tttcgtttat ttcagatgaa gcgaaaaaac 3043621 ggtctgctga tgactgactc ttgatagaaa tgtgaggcga tagaccatgt caccgttcgg 3043681 acagcaatta cgggagctgc gccgcgcccg caaactgaca gtgaatcagc ttgcggtgta 3043741 ctcaggcatc agctcggcca ccatttcaaa aattgaaaac ggcaaacgcg ggacgccaaa 3043801 acccgccacg attaaaaaac tggcagccgt cctgaaagtg ccgtacgaaa acctaatggc 3043861 cgccgcaggc catattcagg cctttcctga agaaatccgc gaagcatctg aaggctatca 3043921 atccgtttat gaaatttacc agacggctgt cacacgcgga gcggagcacc tcccgatttt 3043981 caatagtcaa aaatgggaac atctctcaaa gcaggatatt gaaaatctca gcaaatactt 3044041 cgattttttg tcttcagaag caaaaaaacg cgcctcttcc tcataatccc ctgtttctct 3044101 ttctatattt tatcaatcac gcttgcatgc cctccctcgt tatttgcgtt ataatagtga 3044161 cagacgaggt gaaaagtatg aaccaatcag aaatgtgtcc tagatttgaa aaagcagtcg 3044221 acatcttaag taaacgctgg gtcgctttaa tcgtatttca gctcttgaac gggtcgcagc 3044281 gatttagcga aattgaagca gcacttccaa atctaagcgg cagagttctg tcagaacggc 3044341 tgaaagaact tgagcttgaa ggagtagtga agcgggatgt catccctgaa actccggttc 3044401 gcatcgaata ttcattgact gataaaggaa aggcactagc acccatatta ggtgagattt 3044461 ctaaatgggc gactgaatgg attgaccctt cctttcttga ctaattgcta aaatggttct 3044521 gatctcaaag acgagaaaag aaccgttttt tattttccag gtgaaaaaaa gatatctcag 3044581 ccgatatata gtacatccac acattacgtt tttaaaggag accactatat gcgactgacg 3044641 atttcccgca aattcagcct ggtatttttg acactgatcc tgatcaattt acttgtaggc 3044701 ggaataggcg ttcttaatat gcagcatatc attcaaaaaa cagatgaaat caacacaaaa 3044761 tggattgacg gcatcaaagg aatcacttca attaattatg taaccgagca cctgtcttct 3044821 aaagaaaagg actttctgat ttatacagac aaaagtaaaa tggatacact tgatcaagaa 3044881 atgaatcaaa tcatggaaga cattaaccaa aagctcgata actacgaaaa aacgatctcc 3044941 actgataaag agcagaaact gttcgagcag cttcaaacta aagtgaatac ctatatggat 3045001 attcatgcgc aaattatcga aagcggccgc acgaatgaca tggacaaagc aagaggttta 3045061 ttggttcaga ctgaggccag ctttgaggat atgaaaaaaa caatcactca gcttgttgac 3045121 ttaaatcaag aaggcagcaa cacagcggta aaagaaacga aggccgtcta tcataaaggg 3045181 ctcatttaca ctgctttgct tgtggcagca tcaatcctca tcagcatttt catctggctt 3045241 tatatcacgc gaaacattgt aaagcctatc attcgcatga aggaatctgc caatcatatt 3045301 gccgaaggcg atttgtcgaa cgatatggag gccctcaact caaaagacga gctgggtgat 3045361 ctgaatgaag cgctgcaaaa aatggtaggg aatctgagag atattgtcgg atattctaaa 3045421 gacatatcaa gccgggttct ttcttcttca caggtgcttg caaccgcaac gaatgaaaca 3045481 agatccggca gcaaacatat taccgagacg atgaacgaaa tggctgaggg ctctgaacag 3045541 caggcccaag acgcggtgac gattgccgaa tcgatgaatg agtttaccga aagcattgat 3045601 aaagcctata atcacggcat cacaatcagc gatacgtctc aaaacgttct cgaactcgcg 3045661 gtaagcggga acgaaaatat ggctacgtca ttacagcaaa tgaaaaccat ccatcatatt 3045721 gttgaagaag ccgtgcataa agtgagatca ctggaacagc attctcagga tattaacaag 3045781 ctcgttcagg tcatcaacgg gattgccgag cagacgaatt tgctgtccct taacgccgcg 3045841 attgaagctg cccgcgctgg agaaagcggc aaaggcttcg ccgttgtggc agaggaggtc 3045901 agaaagctgg ctgacggcgt ttctgattcc gtgcaggaca ttacccggat tgtaaacggg 3045961 acacagcagg agatccacac tgtcattacg tacttggaaa gcagctttac agaagtcgaa 3046021 aaaggaacgg aaaacctgac agacaccgga caggctatgc agcatatcaa acaatccgtc 3046081 acccatgttg cagacagcat taaggaagta acggatggct tgaagcagtt aacaaaccaa 3046141 tcgattacca tcaatcaatc gattgaaaat atcgcttctg tatccgaaga gtctgccgcc 3046201 ggcattgaag aaacattttc aattaccgag caatccgccc attcgatgga tcaagtgctt 3046261 ctaaatgctg aagagcttga gcagctggcc aatgagctta atgagaagat gggtcagttt 3046321 acgatttaaa gagaaaaaag aggctggact ccagcctctt tttctattct atgcagctga 3046381 ttgaacatgt ttcgccccgg ttcttttttt cttcaccgga cttaatgccc gctccagcca 3046441 agccatgagc aaatccgccc ctaccgccat caccgcagtt ggtatcgctc cggctagaat 3046501 aatcgcagtt ccgtttgttg cgtttgagcc gcgtacgatc atgtccccaa ggcctccggc 3046561 accgacaaat gtgccgatcg ctgtaattcc gatggcaatg acgagagccg tgcgaaggcc 3046621 cgccataatg acagaaagtg cgagcgggag ctcaaccatt ctgagcactt ggaatttcgt 3046681 catgcccatt gcttttccag attctaagta ggcatgttca atactgataa tgcctgtgta 3046741 cgtgtttcga ataatcggca gcagggaata cagaaataat gatagaatca cggtatttgc 3046801 gccgagcccc ataacaagca ttaagacggc cagcatagcg agcgccggga ttgtttgaat 3046861 aacgtttgtt acggcaaaca cccaggctga caaacggcga aaatgcgcga tgaggattcc 3046921 ggccggaacc ccgacgacag cggcaaataa aacgccgtaa gccgacatga gaaagtggcg 3046981 gccgaattca tccatgacgt aactgccatt ctgcgcgtaa tacgtcatta actgttcaag 3047041 cacgttcatt gacctcttcc ccctttcacg attcgaaata gcgatgtttt tctaaatatt 3047101 ccttggcaac gacagacggt tctttgagat tgccgtcgac ttcatagtta agctcctgca 3047161 tcgtggctgt gtcgattttt ccgagcattt tcttgatgat gccttcaagt tcaggatgtt 3047221 ctttgagcac cttttccgga acaaccggag agcagtcgta cggcgggaaa aattgtttat 3047281 catcctttag cattttgaga ccataggact tgattcttcc atcggttgaa tacgcaagca 3047341 caatgtccat ttttccgctt ttcaccgcgt cgtacacaag gccgatctgc atcggatacg 3047401 tgccgccgaa tgtcatgccg taggttttcg taaaatcctg atagccgttt cctttgagct 3047461 tcatccaata gttatcaacg cccagcttta attgcggcgc ccatttttta acgtctgata 3047521 cggtctctaa atggtattgg tcggccagct ccttgctgac tgtaaaggca tatgtattat 3047581 caaacccgta ggagtcatac cactttaaat catatctttt tttaaactcc cgctgagtaa 3047641 gcgccagcgc tttgtccgga tctttttcag gttccattct caacgtgcct gtcagcgcgt 3047701 ctcccgtata tcttgtggcc gcaatgtcga tttccccgtt cattaaagcc tgctgctgca 3047761 ccgcgttgga gccaagattt ttaatcgttg ttgttttgag atcagtatgg tgttcgatca 3047821 actggccaag catgctggcg atgatttctg attcgctcat gctttgcgcg ccgattttaa 3047881 tggtctggtc tgcagcagcg ctgagaccag gaagcgaaca gccgctcagc gtcagcgttg 3047941 ccgcaagtgc taaacctatc attaatttga gatattttct tttcatgagc cgcctcctta 3048001 tgacaattcc ttcaatctct gcatgccggc aggtgtcagt tttcgttcag caactgccag 3048061 cacataatca atcacaattg ccaatatcgt gacaggtacc gcgcccccga tgatatattc 3048121 cggctgatat aaattcagtc cgataaaaat gtaatcaccc aatccgccgc ctccgataaa 3048181 ggaagcaagc gtggcccagc cgattaagta aatcgtcgat gttctgattc ccgccatgat 3048241 cactggtgcg gcaagcggca gctccaccaa gcggacttgt tcagccggcg tcattcctat 3048301 tcctttacca gactcgagca gatttttgtt gacgccgcga atgccggtat acgtgttgcg 3048361 aagaatcggc aatacggaat agaaaaacaa agccacaatg gccggaacct tccctacacc 3048421 aaggagcggg ataaaaaaag cgaggatggc cagactcggc agcgtctgaa tgatattgac 3048481 aatgccgata atggtgccgg ctcctttttt cattctggta agcacaaccc cgagggggac 3048541 ggcaaccagc acacctaaga tcacagcaat gagcgatatc gtaatatgct cgtatgtttt 3048601 ataaagaagc tctcccccat tggtttgcaa aaattgaaca atatgatgca tgacttatcg 3048661 cccctcccta tgacaatgct gcgagctgct tttcttctcc ccagagggag tcatacacga 3048721 tgtcgaccag acttgccctc gtcacaattc cgatcaggcg tcggtcttca tccacaacgg 3048781 gaacatattt gacaccccgt tttaaaattt tgcggaccgt gtcgcgcagc agtgtgccgc 3048841 ccagtactgt gtatatatct tcatgtaaaa cttcactgac gagattggcc tttttccggc 3048901 attgatcaat gatttcaaca tcgacatagc cttgcagaac gcgctcgtca ttgacgacca 3048961 gcaatgaatc gacccgttcc tgcctcatca gctgaatggc ctcagaaagc gttttatccg 3049021 cggtgatcgt tacaggctgt gtgttcataa tctggtcaac ccgttcaaca tccgggctgg 3049081 atgactgaat cagccgctcc ttgccgataa attcctcaac aaattcgtct gccggatttc 3049141 ttaaaatgtc atcgggcgtt ccaacttgaa cgatttctcc cgcttttaaa atcacaatcc 3049201 ggtctgccag cttaatcgct tcatccatat cgtgggtaac aaatacgatg gttttatgta 3049261 aggttttttg cagtttttta aattcttcct ggagggaatc cctcgtaatc gggtcgagtg 3049321 ccccaaacgg ttcatccatt aagataagcg gcggctccgc ggcaagtgcc cgtaatacac 3049381 caattcgctg ctgctgcccc ccgcttaatt catgagggta acggtctaca tattctggcc 3049441 ccatatcgac caattttaaa agctcacgcg cccgctcttt ccgctgctgc tccggccatt 3049501 tcagcagttt tgggacgagt gagatattct gctgaatggt catatgggga aacaggccga 3049561 tctgctgaat cacatagcca attttgcgcc tgagctctac aggatcctgg tccatgatgt 3049621 tttcgccgtc aatgaaaatc ttcccggcgg aaggctcaat taatcggtta atcattttca 3049681 ttgttgtcgt ttttccgcag ccgctcggcc cgataaagca gataaattcg ccttttgcaa 3049741 tcttaagatt tacgttgttc acggcttttt tgccgccctt gtatgttttc gagacatttt 3049801 ctaatgtcag caaacatcgc acctccaaaa ttaagtttat tcaatttgtt cagtttaaat 3049861 ttaatttttc agacaattga atgcttccca ttatagaata aagtttataa aataaaaagt 3049921 ttacaatttg ttcatattat ttataaagta tgtgtaaacg ctgatttacc cgcattgacg 3049981 tgtgttgatc tccttattgc tccaatttcc tgccaaattc tcttttgaca gcattttcgc 3050041 cgtatcaaaa atgtggtata ttgacatcgg aattgttagc tgaaaggatg aaaccgttgg 3050101 agaaagatcc gttaacgatc attgaacaag ccgaggacca ttttatagaa agaatcgcgg 3050161 aaaacatgca tgcatttgga atgccctcta ccgtcggacg agtgctgggc attatttata 3050221 tgaatcgaaa accgatgacg cttacggaat tatctgaggc caccggcatg agtaaaacac 3050281 gtatgagcca ggtagtgcgg gaaatgcttg atgccaacat tgccgagaag gtattcgaaa 3050341 aaggcgtgcg aaaagattta tatgaggttg agcaggacta ctatcaaaca tttatcacgc 3050401 tgttttcagc cacctggagc aaagtcgtca gcaaaaacaa aatgatgcat aaaaaactca 3050461 atcgggagct gcttagcgtg ttggatgaag agcttactcc tgaagcggaa gaaaaagtga 3050521 atgagctgct gaaggaatta aaggaatggc tcgattatta taattggctc agccgtttga 3050581 ttgagttttt tgagagcgaa gacattttta aatatgtgcc gaagccgtaa aaagttccca 3050641 aattcaattc tgggaacttt tttaagtcca atccaaatgg ttgaatatca aacttcaaga 3050701 aaacaaacaa aataatgcat aatttacatt aatttattaa ttatccattt tttgttgatt 3050761 attctgacta gctattatat aatctttttg aaatgattat attagcttag aggaggtaat 3050821 ctacatcaaa aaaaagggaa ttattactgt aatgactata tgtttcctat tattttcttc 3050881 ttattacttt agcaatattt cacctcagaa tccactgttc aaaaaaaatt ttttgcaaca 3050941 attgtctccc caaggctttg gcttttatag taaaagccct acagaagaaa acatttcatt 3051001 tcacacaaaa gaaaatttaa agttacctaa tgcacttccc aataattttt ttgggataaa 3051061 aagagaagga agagttcagg caatagaatt aggcaaaatt gtagagaata tcgatccaaa 3051121 gaattggaaa acttgtgaaa acaacaactc ctgcacaaat ttagagaaac aaataaagcc 3051181 tattaaggtt ataaaaaatg aagattatat acatcttagc aaaggagaat acctaatata 3051241 tcgccaaaaa ccactctcat ggtattggat agactttaag caaactacct cttttgaaag 3051301 aaaggtgcta aaaataaaaa tagtatgaag atattaaata gtttagaagg ttatattgac 3051361 acctataatc catggaaaaa tacatatgca ctttttagaa gtttacttgg tttctcaaca 3051421 ttactagtac tattattcaa tagtactgat attttattta gttatagtgc aaataatgtc 3051481 acatgtgaaa atgtctatat ccctaccgct ttttgttttg ctaaagaata tagtatcaat 3051541 tttgagatta taagatactt aatgattttt atattaacct tagtggttat agggtggaga 3051601 cctagattta ccggtttatt tcactggtat atttgctata gtattcaaac ttcagcttta 3051661 actatcgatg gtggagagca aattgcaact gttctttctt ttcttatatt acctgttaca 3051721 ttattagatt caaggcgaaa tcattggaat ataaagaaaa acaataatga atctttcaca 3051781 aagaagacag tattgtttta tataatgaca ataattaaaa ttcaagtttt tatcatttat 3051841 ttaaacgcag ctttagagcg attgaaaaat aaagagtggg cagaaggaac agcaatttac 3051901 tatttctttt ctgatccggt gtttggatta cctgaatatc aacttaactt aatgaatcca 3051961 ctacttgaaa gcaattttat tgttgtcatc acttggttag taactatttt tgagttgttc 3052021 ttagcagcaa gcataatttc aaatatcaga ataaagagaa ttgcccttgt tttgggaata 3052081 ttatttcata ttgggataat attcagcatt ggtattgtaa gttttggctt gatcatgata 3052141 tcagcattaa ttatatatct gcatcctgta caacaaaata tcactatgaa ttggtgttct 3052201 cctttattta aatatatata tgtaaaagga aagagaaatt tcaaaagaat aggaggtgaa 3052261 tcagtcaagt ttcttacaaa attgtttcat agctaacatt tagataatgg agaaataact 3052321 taatggaggt ataataattt gaaaagtaaa ttacttaggc tattgattgt ttccatggta 3052381 acgatattgg ttttttcatt agtaggactc tctaaggagt caagtacatc tgctaaagaa 3052441 aaccatacat tttctggaga agattacttt agaggacttt tatttggaca aggggaagtt 3052501 ggtaaattaa tttcaaacga tttggaccct aaactcgtaa aagaggcaaa tagtacagaa 3052561 ggtaaaaagt tagtaaatga tgtagtcaaa tttataaaaa aagatcaacc acaatatatg 3052621 gatgaattga aacaatcgat tgacagcaaa gaccctaaaa aactcattga aaatatgacc 3052681 aaagcagacc aacttatcca aaaatatgct aagaaaaatg aaaacgtaaa atactcttct 3052741 aataaagtta ctccatcttg tgggctttat gccgtctgtg tagcagctgg atatttatat 3052801 gttgtgggcg ttaacgcagt tgcattacaa acggctgccg cagtaacaac tgcagtgtgg 3052861 aaatacgttg ccaaatattc ctcttcagct tctaataatt ctgatttaga agcggctgct 3052921 gcaaaaaccc taaaattgat tcatcaataa tccattataa ttgagtgtct tgcggattgc 3052981 tccgcaagac actttttcaa cgtgaaccgt ttaatttttt gtaataatga tatgaagcta 3053041 gtgttgaaat aactaatgct agaagaacta gcacaatcat aataagaatt atatattctc 3053101 ctgtaaaaaa tgaaagaaca gctattataa aaccacacac tacaagtact ttagaggcaa 3053161 agcgatttcc cagtttccaa acagtctcat cttttaatgt ccaaggtgtc ctcaatccaa 3053221 taagatggtt ttgttctgct agctgcatag aatttccacc aataattaaa aagataccaa 3053281 caccaagccc tattattaaa tcaatattca cttcgtatcc taaacttatc aatagagttg 3053341 agagttgtaa aatatataaa aggattaaca tattattaga agctaggaaa agcaatgctt 3053401 tatttttttg tgtagactta atagttaaca tataaaaagt aagataataa ataagcataa 3053461 caacaggtat aataaatatt gttaaaggtt tagatacaat tgcagccggt ttatttcctg 3053521 accattgtat cggtatttct tctggaaggt attgatataa tataattgaa gtcaagaaac 3053581 tcaaacatac aataattatg gaaattatat ttttcttcat aaatcgttat cccctttatt 3053641 tataaagtta agcatccaat ttattgagtc ttgaagtact gttgtattta gagagtaata 3053701 aataaattgt cctttgcgat ggtcacttat gacttccgct tgctttaaaa tattcaagtg 3053761 gtgcgaaata ctcggtttgc tgatattaaa atgctcagca atatctcccg cagtcatatc 3053821 ccctcctttt aacaaatcca aaatttttct ccttgttgga tctgatatag ctttgaaaac 3053881 attattcata gcgttttctc ctttacaaaa aaacatttag acatttagat atttgtataa 3053941 atgtattatt ttcattataa cttgaatttt tttaaaaaca accctcaaat tggttataat 3054001 atctgatttt tgtatttttt caaatactcg gataatccca acgctggaaa atatgtttaa 3054061 cagatactaa cacatgttgt ttatttaaaa aaaccacctc tgttgtattt aaatagaggt 3054121 ggtttttcta tcagctataa taaaatttcc ttttttcttt ttaatcgggc ttaatgctcg 3054181 ttcaagccag cccatgacca aatcggcaat caccgccatc agagctgtgg ggatcgctcc 3054241 cgctaatata atcgcggttc cgtttgtggc gtttgatcct ctgacgatga tgtccccgag 3054301 accgccagca ccgacaaatg tcccgatggc cgtaatgccg atcgcaatga caagcgcggt 3054361 gcgcaggccg gccattatga cagaaagcgc aagcggaagc tcgaccatcc gcagcacttg 3054421 aaattttgtc atccccattg cttttcccga ttcaagatag gcgtgctcaa tactgataat 3054481 ccctgtatac gtatttctga taatcggcag aagagaatac agaaataatg acaatatcac 3054541 cgtattagcg cccagcccca tgacaagcat cagcacggcg agcatggcga gagccgggat 3054601 ggtctgaatg acattcgtga ccgcaaaaac ccatccgctt aatcttctgt atctggctat 3054661 caggatgccg agcggaattc caacaatggc ggcaaataaa acgccataca ccgacatcag 3054721 aaaatggcgg taaaattcct gcagcacgta accgccgttt tgcgaatagt atgtgccaag 3054781 ctgctgtagt acttccatat gatccacctc ttttcttagt caaaataatg atgtttctct 3054841 aaaaattcct ttgctacgac agacggctcc ttcagcttgc catccacctc ataattaagt 3054901 tcctgcatcg tttccgtgtc gatttgccca atcagcttat tgatcacacc ttcaagttcc 3054961 ggatgctcct taagcacctt ttccggaatc accggtgaac agtcatacgg cggaaagaaa 3055021 cgcttatcgt cttttaagat tttcagatca tatgctttaa tccgtccatc cgttgaataa 3055081 gccaaaaccg catccatttt cccgtttttg actgcgtcat agactagccc gatctgcatt 3055141 ggataagttg tgccgaactc aaagccatat gtgctgacaa agcctttata cccgtcgcct 3055201 tttcgtttca gccaagcatt gtcgacgcct aatttatatt gggaagcatt tttcttcagg 3055261 tcagacacgg tgttaatatg ctccttttcc gcaaactttt ttgttacggt gaaggcatat 3055321 gtgttatcaa agccgtagga atcaaaccat ttataagaaa agcgcttttg aaactcgttc 3055381 tgcacaatgt tcagcgcttt tttcggatct ttctccgctt ccttgccgag ggtgcttgtt 3055441 aaatctgttc cggaatagcg cgtggctgaa atatcaatgt caccgcccag catcgcttgg 3055501 tgctgaacat agtttgagcc gaggtttttc actaaagcag tattcaaatc tgtatcatgt 3055561 tcaataagct gcgcgatcat attcgctaca atttctgatt ctgtcatgct ctgcgccccg 3055621 attttgatcg tatcgtcaga agcgccgcct agacccggca gagagcagcc gcctagcagc 3055681 atgacaaaga cgagagcaaa cgcgccaagc catttgattt ttgtcatttt caacagtgcc 3055741 aactccttac gatacttcct tcatcccttg caagcctttc ggcgtcacct ttcgttctgt 3055801 cacagccaga acataatcaa taataattgc cagaattgtg acaggcacgg caccgccaat 3055861 gatatattca ggctggtata ggttcagtcc gataaaaata tagtccccga ggccgcctcc 3055921 cccgataaac gacgcaagtg tcgcccagcc aattaggtag atcgttgatg tgcggatccc 3055981 cgccatgatg atgggaatcg ccagcgggat ttcaacgagc cgaatctgct cccagccggt 3056041 catgccaatt cctttccccg attccaggag gtttttattt acacctttaa tgccggtata 3056101 cgtattgcgc aggatcggca gtaccgaata gaaaaataaa gcgacaatcg caggcacttt 3056161 tcctacgccg agaagcggaa taaaaaaggc taaaatcgcc agactcggca gggtttgcac 3056221 aatgtttacg aaaccgataa ccgcacctgc gccttttttc attctggtaa gagcaacgcc 3056281 gagcggcact gcaacgataa tgcccaatac aacggctatg agtgaaatat ataaatgctc 3056341 tcctgtttta tacagcagct ctccgccgtt cgtttgcaaa aaagtcatca tttgattcat 3056401 cttaaaagag ctcctcccct ggtcagatcg tcatgagctg gttttcctcg tcgccccaaa 3056461 tggaatcgta tacgatatca acgaggctcg ctcttgtcac aatccctgct aaatggttct 3056521 gttcatcgac caccggaaca tacttgatcc cctgcttcaa aatttttcgg actgtatcgc 3056581 gaagaagcgc ccctttttga acggtatata tatctgaacg gtatacatcg ccaacgatgc 3056641 tcgctttttt gcggttttga tcaatcattt ccacatcaac atagcccttc agcacgtttt 3056701 gccggtccac aacgagcagc gagtcaacac gtttttctct catcagctga atcgcctgag 3056761 aaagcgtttt gtccgcagat accgtcaccg gcgttctgtt catcatttgc tctacccgct 3056821 cgatatccgg tcttgactga atcaggcgct ctttcccgat aaattcttca acaaactcat 3056881 ttgccgggtt tcgaagaatc tcatcaggtg tgccgacttg aacgatttct cccgctttta 3056941 atatcacaat cctgtcagca agcttaatcg cttcatccat atcgtgggtt acaaacacaa 3057001 tcgttttgtt taaggttctc tgcagttttt tgaattcttc ctgaagggaa tcacgcgtaa 3057061 tcggatcaag cgctccgaac ggttcatcca ttaaaatgag agggggttcc gctgccaggg 3057121 cgcgcagcac gccgattctc tgctgctgtc cgccgctgag ctcatgcgga taacggtcta 3057181 aatactctgg gcccatatcc acaagcttta acagctcgcg cgcccgttct ttccgttttt 3057241 cctcaggcca tttcagcagc tttggtacga gtgagatgtt ctgctggatg gtcatatggg 3057301 ggaacaaacc aatctgctgt atcacatagc cgatttttct cctcagctca accgggtcct 3057361 gttccataat attttctccg tcgataaaga tccttccaga cgatggttct atcagtctgt 3057421 tgatcatctt catcgtcgtc gtttttccgc agccgctcgg gccgataaaa cagataaatt 3057481 caccttttgc aatatctaaa tcaatgctgt tcacagcttt tttgccgcct ttatatactt 3057541 ttgacacttg ttccaatttc agcaatccgt gcacctccgc aggtttcctt taaattttct 3057601 gaaaagtata atccttatta tagtttgaac tttgtaaaat aaaaagttta caatgtgttg 3057661 aaattatatg ttatttatag attatttatt gttatgaccg agacggaaag ggtgttctta 3057721 caattactcc ggatacctcc cacttcctct gcattcagct attttcaaca ccaggaagaa 3057781 atatgatata ttgacaccat caattgccat ttgaagggat gatcagctgt gaaaaaaacc 3057841 gctctcgaca tcattgaaca tgctgaagag catctcattg agaagattgc cgaaaatatg 3057901 catacgtttg gaatgccttc aactgtcgga cgtgtgctcg gaattattta tatgaatcga 3057961 aaaccaatga ccttaagcga gctctctgag gcaacgggca tgagcaaaac acggatgagc 3058021 caggttgtcc gggaaatgat cgatgccaat atcgccgaaa aggtgtttga aaaaggcgta 3058081 cgaaaagacc tttatgacgt cgagcaggat tattatcaaa ccttcatttc tttatttgcg 3058141 gcgaattgga caaaggtcgt gagcaaaaac aaagtgctgt ataaaaaatt aaaccgggag 3058201 ctgagtgatc ttttacaaag ggacgggctt accccggaag cggaagagaa agtcaatcag 3058261 ctgctgaatg aattaaaaga atggcttcat tactatgatt ggctgagcag gttgattgaa 3058321 ttttttgaga gtgaggaagt ctttcggtat gtgccgaaaa caaaagaatg cagctctcta 3058381 aaataagaga gctgcttttt gcatcatgaa gttaagaccg gaaacatgcc tttcagcccg 3058441 gcaccaatca tcccgaccgc aaccacggct aagattaatc ccatcagtct ggtaatcaca 3058501 ttcatctcgg tttttccgag tttgctgctg ataaaagcag aatagtggaa aaagagaaag 3058561 gtcagggcaa taacggcggc tatgccgatc atgacagccg cataatgacc aatgccgcta 3058621 tgtccggcgg aaaggctcat cactgttgca atcgttccgg gcccagcaat gatcggaatg 3058681 gataaaggtg tgactgatat atccgctttt tccttgcttt ccttatgttc atcatggtga 3058741 agagattgca cgtgcgattc tttcgcattc aatagattat aggcaatgcc gaaaatgaat 3058801 atgccgcccg ccactcggag cgcgtgaatg ttgatatcaa acagtttaaa gataagatga 3058861 ccgaaaacca aaaaagctgc gagaataaaa aaggataaaa tagctgcctt ccgggcaatc 3058921 gcttttcttt ccgctgcagt atagccttct gtcagcgtca gaaatatcgg tacgtttccg 3058981 atcggattcg atactgcgaa taaagaaatg aagacgtgaa cgataaatga gaacatcata 3059041 tacctccttg ttgatagtct ctgcacagga aatagaatga ttctccaccc ttttacccgg 3059101 aggcgatttc ccggtaaacc tttatagcct gtcagaaacg cgccatgcta caatgaagtg 3059161 acaaattgaa taggaaggac gtatacagat gttcaaaaaa attgcggcag atgccttggg 3059221 cttatctgat atcggaaaaa ttatcgaacc tcaggactat gacaaaacag acgcagatga 3059281 ctatgtcatg catgaagata atgagaaaat ttatttcttg attaaaacaa aagcagacga 3059341 gtattgcttt acgaacctgg ccctgatcca tgtggacggc gaacgcgcca cttcctcaaa 3059401 acgaacgttg aaacgctatc cttattcgca atataaaatc tctgacgttt ttcttgaaac 3059461 tgccggaaaa gtggatttgg atgttgaaat taagttcaag ctgggcggtg aacaattcga 3059521 cattgatgtc cacaaagacc agattgaaaa gttaaaagac ctttataaag cactgcttcg 3059581 catcgctgaa acaacctatg aaaatgacat tttaatcaat caagcggagc aaagcttaga 3059641 taaagcagtg acgattcttc accatacccg ccctgagcac gtcaatattg aaacgcaata 3059701 caaagagctg accgaattcg gattcacttg gctgacatcc gttcgctcgc agtatcatat 3059761 taaggatttt ggggatgtat ttgagaaata tattaataac tagataaaaa aagacacagc 3059821 tgctatcgtg ctcgtgtctt tttttgtatg aatattgatt actttacaac ttttttcttt 3059881 tataataaaa ctattagtct attttcccta tattacagat aaaggagtta ttttatgtat 3059941 tgtcctcaat gcggccatca aacagatggc ggaaattttt gtgagaaatg cggatcaccg 3060001 ctccccggtc aatcaggcca ccagcatgca gctcaaactg gagccgctgc aaagcaagca 3060061 gcaaaacagt tcggttcatt tgtcttatcc gtcctgaaac gcccttatca ggaatgtaaa 3060121 gcaacaggcg gagaacagct gatcagcgca atcattacga tggttctttt cagtttgctg 3060181 acccctttga tgttttatat tcttttttca gacggtcccg gaagcgtaag ctttacagca 3060241 atcttcttag agccaaccat ttattttatt ttatttctat ttggcctgca tgcatgcatc 3060301 tttttcgccc tgaaaatcgc gggaaaccaa gtgtctttca aggattcatt ctcaagattc 3060361 ggagcatttc ttattccttt tacggctatt ttgattcttg cccttttctt ctttttatta 3060421 catacagaca tttgctttac catattagcc gttggtttaa tcggtgcatt cttcgccatt 3060481 cctcctgcga tgctgagcag ttaccagcat tcatataaag ggaaggttga tttcatttac 3060541 tcaacgattg tgatttatct gatcatctgc gttacatttc agcttattat cgaacactat 3060601 gtcaaagaaa ttttccgtta tatgctcttt taaaaacaac cccatcacct gctggtgatg 3060661 gggttgtttt attgaataga cgttaagtaa attcttccgt tcttcactac gccggtgtag 3060721 gtccagttat atgttctgag ctttggactg ccgcctgatt ttgtgatata gaattcttca 3060781 tacgtcttaa tcgtgatagc cgacccattt tggctccagc ttttcacttc atagttatta 3060841 aagtcttctg ttgtcccctc tttatttaat ttcgacacga gatgctgctg gtcggaataa 3060901 agggaactgc ctttttcaag gctgtcttcc atcagtgaga aattattttg attcacggca 3060961 tctgcctgac tttgcagata actgcccata aataatgtca cttgttcatc tgtaacatcg 3061021 ccgcttgcag agctttcact gcctttgttt ttcgagccag cccaggcgga agtgtatgtc 3061081 tctggtttat catttttgat tttctttata tttgtgcctg cagattcgaa tgttgattct 3061141 gcatcttcga aaatccactt tttctgtttt ttatcatatg aaagaagata ttcataactc 3061201 ggactgtcgt cagtcatttc agactttgta tagtcgttat acgaagaaga ctggtgaagt 3061261 tcttttcctg ttaccgatac ctgccacgtt ccgtcgtttt tctgagagag ggcaaatgtg 3061321 tccaggtcaa aatcagtttc caagtatcta tcttttaagt atgaatccgc gcttttcata 3061381 gaatcgacgg tgtccttcgt ctccgccttc caattggcac ttgcctctgt catctgggct 3061441 gtattcccat cagatagagc tttggagtat tgttttgttg ttttgacaat tgtgttcata 3061501 atctgttcct gtgtatcttg atcaggaatt aacgttaact ccatttcttt atcatcgatc 3061561 ggaacgccgg cagtttttgt ttttccccac ggaaattctg cctcgactga agctgtcatt 3061621 gatccatctg tcagcagcgg accatatgtt acggatttga acggatcttt atgaattgat 3061681 ttaccgttaa tcagcaaatc tcccttcccg ctcttgatgt cattcgctaa gctgaatgtc 3061741 acatcgtctg cttccaatga gagatcaaca cgaaagctgc tatcgccaat cgcctgaatg 3061801 tcttcctttt tcacaaggtc aacgacatcg tttttcagtt tggctgagac tgtatattcg 3061861 ccgggaatgt acggaccaag ggtttgtgct tgatctgctt tctttacaga tccggcttcc 3061921 tctttattga catatagatc ggtattttta taattgctgc tcacttcaaa ataaacaggt 3061981 gctaccttta agtcataatg gtcaaatacc agcaggcttt tcccgtcttt ttccgcatat 3062041 acgatatcct tctgggctgt ttcatcacgc agcgatgcaa aaagttcatc ttttttgtct 3062101 ggatgatcct tcaaatatgt aagaaacggt tttacattat ttttagtgag tttaagattg 3062161 tcatttaccg gtgtaagcag agtcgcgatt tggtcctgat ccccatcatt tacggcctgt 3062221 tcaaacttgt ctactaacct atcctttgaa gtaaaatacg ctccggtttt atatgcggcg 3062281 aataatataa cgcacgccgc ggcaatgctg ctccataaaa tgatggtttt cttagggatc 3062341 ggttttcgcg gagcctgcct cgtttctgca gtgctagctg tttcttgatt tgcctgtttg 3062401 ctgccccctc cgatcggggt gccgcattgt ttacaaaact tggctccttc attattctgg 3062461 gagccgcaat tcttacaaaa taacatgact ttcctcctat tctactaatt tgataacatt 3062521 tactgctttt catattttat aataaaacag aatgaaattg ggaacgaatg aaaaaattaa 3062581 atgtctatca gactaaaaag gtggaatgaa tatgcaaaag ctcaggattg aattaggaga 3062641 agaaacaaat gacgaattat atgatctatt gctgctcgcc gatccatcga aagacattgt 3062701 agatgaatat cttgagaggg gagaatgtta cacagcttgg gccggtgatg agcttgcagg 3062761 ggtttatgta ttgctaaaaa caaggccgca aacagttgaa attgtaaata ttgcggtaaa 3062821 agaatctctt cagaagaaag gctttggcaa acagcttgta cttgacgcca tcgaaaaagc 3062881 gaagaagctg ggggcggaca cgattgaaat cggaacgggg aattcgagca ttcatcagct 3062941 ttccctctat caaaaatgcg gattccgcat tcaggcgatc gaccacgatt tctttctcag 3063001 acattatgat gaggacattt ttgaaaacgg gattcaatgc cgcgatatgg taaggcttta 3063061 tttggatctc tgaaagcata aaaaagccgc cgagagaaaa tcccggcggt ctttttatta 3063121 cttgtttaag ttgtagaaag agttgatacc gtggtattga gcagtttcag ccaactgatc 3063181 ttcgatgcga agaagctggt tgtatttcgc aacacggtcc gtacgagacg gagcacctgt 3063241 tttgatttgt cctgcgtttg ttgccacagc gatgtcagcg attgtgctgt cttcagtttc 3063301 accagaacgg tgagagataa cagctgtgta gcctgcgcgt ttcgccattt cgatcgcatc 3063361 gaatgtttca gtcaatgtac cgatttggtt tactttgatc aggatagagt tgcctacgcc 3063421 gtttttaata ccttcagaaa gttttttcgt gtttgtaacg aagaggtcgt caccaacaag 3063481 ctgaactttt ttgccaagac gctcagtaag aagcttgtgg ccttcccagt cgttttcgtc 3063541 aagtccgtct tcgatcgaga tgattgggta tttagaaaca agctcttcat accagtcaac 3063601 catttcagca gatgttttca caacgccttc gccagacaga tggtatttgc cgtcttcttt 3063661 gttgtagaac tcagaagatg cagcatccat agcaagttta acttcttcgc caggtttgaa 3063721 gccggctttt tcgattgctt caacgattgt ttgaagcgct tcttcgttag aaccaaggtt 3063781 tggagcgaat ccgccttcgt cacctacagc agtgtttaag ccttttgcgc ttaatactga 3063841 tttcaggctg tggaagattt gagcgcccat gcgaagtgct tcacggaagt taggagcacc 3063901 tacaggcatg atcatgaatt cttgaatatc cacgttgtta tcagcatgct ctccgccgtt 3063961 tacgatgttc atcatcggta caggaagcgt ttttgagttg aatcctccaa ggtattggta 3064021 aagaggaatc tgtaagaaat cagcagcagc acgcgcacaa gccatagata cgccaaggat 3064081 tgcgttcgca ccaagtttgc ctttgttttc agtaccgtca agctcgatta aaagctgatc 3064141 gattgcgttt tgttcagtta catcaaagcc aagaagctct ggagcaatga tttcgtttac 3064201 gttgttaaca gctgttaaca cgccttttcc aaggtaacgg tctttgtcgc cgtcacgaag 3064261 ctcaaccgct tcgtattcac ctgtagaagc tccgcttggc actaatgcgc ggccgaaagc 3064321 tcctgtttct gtatatactt caacttcaac tgttgggttg ccgcgggagt ctaatacttc 3064381 gcgtgcataa acatcaacaa tgtatggcat gagttttgtc tctccttttg attttcaaat 3064441 tatttttgaa ttaaagatgt tcctgtcatt tctttcggtt tttcaacacc aagaaggtct 3064501 aataacgttg gtgcaaggtc gcctaggatt ccgccttcac gcagcgtaat gccttctttc 3064561 gttacaatca cagggactgg gtttgttgta tgcgcagtgt gcggttcgcc tgattctgta 3064621 atcagaatgt cagcattacc gtgatcagcg gtaatgatag cgtgtccgcc tttagcaagg 3064681 atcgcgtcaa cgacttcgcc caagcattcg tccactgctt caattgcttt aattgttggt 3064741 tcaaccattc cggagtggcc gaccatatca gggtttgcga agttaagaat gatcgcgtca 3064801 tgcttgtcag cttcaatttc tttgacaagc gcgtctttca cttcatacgc actcatctca 3064861 ggcttcaagt catacgttgc aactttaggc gagttgatga gaatacgctc ttcacccggg 3064921 aattcagctt cacggccgcc gctcataaag aacgtgacgt gcggatactt ttcagtttct 3064981 gcaattcgaa gctgttttaa cccgtgctga gataatactt ctccgactgt gttatcaaga 3065041 tttatcggtt taaacgctac atagccgtca actgtttcac tgaagtgagt caggcagacg 3065101 aaatacaggt tctttggata attctcgccg cggtcgaagt cacggaagtc tttgtttgtg 3065161 aacgtgttgg aaatctggat ggcgcggtcc ggtctgaaat tatagaaaat cacagaatcg 3065221 ccgtcttgga ttttcgcaac aggctcaccg ttttcttttg tgatgacaga tggaatcacg 3065281 aattcatcgt agataccatt tgcatatgaa tcatcaacaa catccagggc gctgcggtaa 3065341 gatgggcctt cgccgtacgc cattgcgcgg tacgcttttt ctacacggtc ccagcgtttg 3065401 tcgcggtcca tagagtagta acgtccggaa atgctggcga tttcacctac accgatttcc 3065461 ttgatttgat cgttcaactg gttgatgtac gttttcgctg tctgcggacc tacatcacgg 3065521 ccgtcaagga agccatggat ataaaccttt gtcagccctt cttttttcgc aagctttaac 3065581 agtgcgaata aatgattgat atggctgtgc acgcctccgt cagataaaag accgaacagg 3065641 tgcaaggctt tgttgttttc tttcgcgttg ctgatcgcgt caaggaatgt ttgattgcgt 3065701 tcgaactctc cttcacgaat ggcaacattt acgcgtgtta agctttggta cacaatacgt 3065761 cccgcaccga tatttaagtg acctacttcg gagttcccca tttgcccttc aggaagacct 3065821 acagcctcgc ctgaagcagt caaagtttga tgaggatact ggttccaata gcggtcaaaa 3065881 ttcggttttt tcgctaaagc gactgcgttc cctactgttt cgttacgtaa tccgaaccca 3065941 tcaagaatga tgagtgcagc tggtttttta ctcatattga ccttcctcca ataattgaac 3066001 gaatgactgt ggctcaaggc tcgcgccgcc gaccaaagca ccgtcaatat cggactctgc 3066061 catatattct ttaatgtttg caggctttac gcttccgcca tattggatgc gaagcttgtc 3066121 tgcagcttct tggctgaagc tttcagcgac ggttttacgg atatgcgcac acacgtcatt 3066181 cgcatctttc gctgtagaag atttgcctgt tccgattgcc cagattggct catacgcaat 3066241 aacagaagca gcaacttgtt cttcagaaag accagcaagg ccttttttca cttggtcagc 3066301 aacaagatca tttgttttgc cggcttcacg ctcttcaagc gtttcaccta cacagatgat 3066361 cggcacaatg ccgtgtttga aagctgcgtg tgcttttttg ttaactgttt catcagtttc 3066421 agcgaacatt tcacggcgct cagagtggcc gatgacgcag tagtcaacgc caaggtcttt 3066481 cagagcaacc gggctgattt cgcctgtgaa cgcgccgctt tcttcgaagt gcatgttttg 3066541 agcgccgact tttaggtcag tgcctttcac agcagaagca agcttttcta agaaaagcgc 3066601 tggcgcgcaa acaacagctt cagctttgtc tgctgctgga atggaagatt tcacttcttc 3066661 aacgaagctg acagcttcgc cgagtgtttt gttcattttc cagttaccgg cgataattgg 3066721 ttttctcatc tgttccactt ccttatagca gttttgagat tatttatcgt tcagtgcagc 3066781 tacccctgga agctctttgc cttccataaa ctcaagggat gcgccgccgc ctgttgagat 3066841 gtggctcatt ttgtcagcaa ggccgaattt ttcaaccgct gccgcagagt ctcctccgcc 3066901 gatgacagag tatgtatctt tcgcctctgc caatgcttcc gcaaccgctt ttgttccttg 3066961 agcgaacaag tcgatttcga atacgcccat tggtccgttc cacacgacaa gtttgctgtt 3067021 tttgatgacg tcagcatacg tttcgcgtgt tttcgtacca atgtcgattg cttctaaatc 3067081 actagggatt tcagagatcg gcacaatttt cacgtttgca tcgttagaga aatcatctgc 3067141 aacgagtaca tcttcaggca tgtagaagtt aacgcctttt tctttagcgc ggtccataaa 3067201 tgatttcgca agctcgattt tatcctcttc aagaagagat ttcccgactt catagccaag 3067261 cgcttttacg aaagtataag caagacctcc gccgatgatc aggttgtcta ctttatcaag 3067321 aagactttcg attacaccga ttttgtcttt tactttcgct ccgccgatga tcgctgtgaa 3067381 cgggcggtca ggattggaaa ccgcttttcc aagtacatca agctcttttt ccattaagaa 3067441 acctgcaact gctggcagat gctcggcaat tccagctgta gatgcgtgag cacggtgggc 3067501 agcaccgaat gcgtcattta catatacatc tgcaagctca gcaaatgctt ttgcaagctc 3067561 aggatcattt ttctcttcac caggatagaa acgtacgttt tccaatacaa gaacgtctcc 3067621 gtccttcatc tcagaaattt gtgcttttac agcatcgccg tatgcttcat ccgctttttt 3067681 cacttctttg ccaagcagtt cgccgagacg tgcagcgaca ggagttaaac gaagctcctc 3067741 aaccacttcg cctttcgggc ggcctaagtg gctcgcaaga aggacttttg cgccttggtc 3067801 tgcaaggtgt ttgattgttg gaagcgcagc acggatacgt gtatcgtctg ttacttcccc 3067861 gtctttcatt ggaacgttaa agtcaacgcg gcagaataca actttgcctt ttacgtcgat 3067921 gtctttgaga gtttttttat tcatgcctag gagatcctcc ttcaaaatgg tttgcataca 3067981 gcacgaaaaa cgtgaaaccg tctgttcaag cgataactcc gctagggcag atcgcagtct 3068041 ttttcggcac agggcagttc gtctaaaagc cagggcagcg gccttaggcg aaagcgccgg 3068101 caaagctgct taaaacgcgg tcgtttctct atcacagagc gttttctgaa agccggtctt 3068161 catggaaaaa gggaaaggga gtccgtcccc ttcccttgtc cgctttcatt atagcgcttc 3068221 tattcgaaag aaccaagtca ggtccttttt cagctataaa ttaaagacct ttttttgcga 3068281 tgtaagctgc aaggtcaaca acgcggttag agtagccgct ttcgttatcg taccaagaga 3068341 ttacttttac catgctgcct tccataacca ttgtagaaag agcatcgatt gtagaagagt 3068401 ttttgtttcc gttgtagtcg ccagaaacta atggctcttc gctgtagcca aggattcctt 3068461 taaggtcgcc ttcagccgct tctttaagag ctgcgtttac ttcttcagct gttacttctt 3068521 ggttcagttc agcaaccaag tcaactagag aaacgtttgg agttggaaca cgcattgctc 3068581 caccgttcag tttgcctttt agttcaggaa gaactagaga aactgcttta gcagcaccag 3068641 ttgatgttgg gatgatgttt tcagctgctg cacgcgcacg acggtagtct ttgtgcggaa 3068701 gatcaaggat ttgctgatcg tttgtgtaag agtgaacagt tgtcatcata ccgcgtttga 3068761 tgccgaattt atcgttaagt acttttgcaa acggcgcaag gcagtttgtt gtgcaagatg 3068821 cgttagagat aacatcgtgg ttagccgcat cgtatttatc ttcgttaaca cccataacga 3068881 ttgtgatatc ttcttcgtta gcaggagcag agatgattac ttttttcgcg ccagcttcta 3068941 agtgtttcgc agcgtctgcg cgttttgtga agaaaccagt agattcaact acgatttcaa 3069001 cgccttgttt gccccagcta agtttagcag gatcgcgttc tgcagaaact tcaattgttt 3069061 tgccgttaac aacaaggttg ttaccgtcaa ctgaaacttc agcgtctaat tttccgtgta 3069121 cagaatcata ttgtaaaagg tgagccagca tgttagcatc tgttaaatcg ttaaccgcta 3069181 ctacctcaac ttcaggattg tttaatgctg cgcggaatac gttacgtcca atacgaccaa 3069241 aaccgttaat accgactttt actgccatga ttgtttcctc ctttaaataa gtgagagata 3069301 tttatattga gggattattc atcccttaat aacttctttg cggctccttc gtctgtgacg 3069361 agaaccgtgt tgcgtggctt tttaaagtaa gcctcgatcg cttcggcttt tgatgatccg 3069421 cccgctaccg caataatatc ggggatggcg tctatgtcat ccagctgcat tccgacagaa 3069481 tgcactttgt gaaccacttc gccgtccgcg ttaaaatagt agccgaacgc ttccgtcacc 3069541 gcgtcgttat catctatttt ctttaaatct tctaaaggcg tgtttctgcg ctgagccata 3069601 gttttagctt cgccgattcc gtgaaccagc atactcgctg atttaatggt gttcagcacc 3069661 tctttgacag aaggctcttc aataatagat gaataggcgc cttgtgacag ctgtcccgga 3069721 acaaacaaaa gccggtaagt gcctgaagcc ttctccgcca tatgcgcgca tatggtgttc 3069781 gcctggtttt tcacgtcttc gcctaaaccg cctcttgcag gcacaaacaa aagctcgcgg 3069841 tttttagaat ccggcgtcat catttcggcg acagcttcaa ttgtcgtacc gccagttaca 3069901 gcgacgatat ttttgcctga aaatcttttt ttcatacatg cgacagccgc tcttcccatt 3069961 tcttttttga cccatgggga ttgatcgctg tctccggata cgataatggc atcctttaga 3070021 tttaaacgtt cttttaatgt cttttccaaa agagtcaaac ctaaaacatc tttcatcgta 3070081 tcttccaaaa cagaaagcag ttcatagccc tcttctgtca atgtcatgcc gtttgtctta 3070141 atatcgacca ggttctgttc ctttaaaaac tgaacctcgc ccctcagcac acgctcgctg 3070201 attccgagac tggcagacag gcttcttcgc ccgatgggtt ctgtcagcct gatatactgc 3070261 aagatttcaa acctcttttg cataacgagc agaagatcag gcaataattt tttttgagct 3070321 tgtattaact ggttcatgac tcaaacgttc cttccttttt tgctggacat tatatgtccc 3070381 gctatgacaa aaaacgtccc gtcatagcca aaaaaaatca tttctgcttt ctttaattat 3070441 tttaacaggg tggaattgtt tattcaactg ttaagagcca attcatcgac aatattcgca 3070501 gagttttcat gccgcgtcgt tttatccagc aatattttat cctatatatc tttatcttat 3070561 acagaaagcg ccaaatggtg catcccaata taaacagccc ttcccgtaga aagggctgtt 3070621 tcattaaagc gttttcattt tatccaaagc ttttcaattt cctcgagcga tttgttcttc 3070681 gtttctggac agatcgtaac gacaaacagg aaacaaagga tgttaatcac cgcaaagatc 3070741 caaaatgtat aggcgagccc gaaagaatcg atcatcattg gcacaaactg tccgatcgcc 3070801 cagtttgctc cccataaaaa gatggtcgca atgcccgcgg cccgcgcacg cagatggttc 3070861 gggaagattt cagaaatcat aatccatgtg atcggtccga ccgagacaca gaaagcagcg 3070921 acaaaaccta atataaggac gatcatcatg atcccgcttg ttaactcaaa ataaaacgac 3070981 gtcccgatta aaatcataaa aatagccata aaagcagaac cgatggacat cagttttttt 3071041 cgtccgactt tatcaatcag caacaccgca ataacggtaa aaataacttc tacaaccccg 3071101 acgatacaag tcgtcacaaa tccggcgttt tgcccgaatc ccatcatttt aaagatttcc 3071161 ggcccgtagt aagtaatcgc gttcatgccg atgacttggt taaacagcgc cagcaggatt 3071221 ccaatgacaa gcgcctttct gagacccggc ttaaacagct gggagagcga ccccatttgt 3071281 tctattttta aagagttctc aatgttcttt aattcttctt ttgcaacagt ttctccatta 3071341 atacgtgtca ggatctttaa agcttcattt gttttgcccg ctttcgccag ccatctcgga 3071401 ctttccggga cgacgagcag gacaaggaaa aaaatgacgg atggcaccat tccataagca 3071461 agcatccatc tccagccggt gtgcacgccc cattcgtatg ttccggaccg ctgcacagct 3071521 agattaataa agtatgttgc ggaaataccc agtatcgtaa agagctgata taacgaagat 3071581 aaacttccgc gtatagcggg cggtgccgct tctgtaatat acgtaacaga gagcgatgag 3071641 cccatcccga ttcccagccc cccgataatc cttgcaatga ttaaggtgga cacgtcttga 3071701 gaaagcgctg aaacgattgc tgatatcgca aataacaaag cggctgtcat taaaattttt 3071761 ctccggccga atctgtcact taaaaatccg gatatcccga cgcccacaac tcctccaatc 3071821 ataatgcttg aaatgacaag tccctccata aacggactca ggctgtataa atctttcaga 3071881 aaaccgatgg cgccagaaat cactgccgtg tcatagccat acaataagcc gccaagcccc 3071941 gccgcacatg agatcaaaat gacaaatccc attgaatggc ttcttgttac aggaacattt 3072001 ggttctaatt gagttggagt attcttcatt tccctgccct cccgaatgtt gagtaaagcg 3072061 ttttcattta aaccttcaat tgtacgtact tatattaaaa tttaacgaaa attacattta 3072121 attagtacgt acaaatatag aataatcttg tttgcatttt ctgtcaatgt tttcttacaa 3072181 agaacgctgt gatatactga aatttgtccg tatacatttt ggaggaatgg atatgttacc 3072241 aaaatacgcg caagtaaaag aagaaatcag ttcttggatt aatcaaggca aaatactgcc 3072301 cgatcaaaaa atccctaccg aaaacgaatt aatgcagcaa ttcggcgtca gccggcatac 3072361 catccgcaaa gcgatcggag acctcgtatc acaaggtctg ctgtacagcg tgcaaggcgg 3072421 aggcaccttt gtcgcttcac gctctgctaa gtcagcgctg cattccaata aaacgatcgg 3072481 tgttttgaca acttacatat cagactatat tttcccgagc atcatcagag gaatcgagtc 3072541 ctatttaagc gagcaggggt attctatgct tttgacaagc acaaacaaca acccggacaa 3072601 tgaaagaaga ggcttagaaa acctgctgtc ccagcatatt gacggactca tcgtagaacc 3072661 gacaaaaagc gcccttcaaa ccccaaacat cggctattat ctgaacttgg agaaaaacgg 3072721 cattcctttt gcgatgatta acgcgtcata tgccgagctt gccgcgccaa gttttacctt 3072781 ggatgatgtg aaaggcggga tgatggcggc ggagcatttg ctttctctcg gccacacgca 3072841 tatgatgggt atttttaaag ctgatgacac acaaggcgtg aaacggatga acggatttat 3072901 acaggcgcac cgggagcgtg agttgtttcc ttctccggat atgatcgtga catttacaac 3072961 ggaagaaaaa gaatcaaaac ttctggagaa agtaaaagcc acactggaga aaaacagcaa 3073021 gcacatgccg acagccattc tttgttataa cgatgaaatt gcgctgaagg tgattgatat 3073081 gctgagggag atggatctta aagtgccgga ggatatgtct attgtcgggt acgatgattc 3073141 acatttcgcc caaatctcag aagtgaaact aacctctgtc aaacatccga aatcagtgct 3073201 tggaaaagca gccgccaaat atgtcattga ctgcttagag cataaaaagc cgaagcaaga 3073261 ggatgtcata tttgagcctg agttgatcat tcgccagtcc gcacgaaaac tgaatgaata 3073321 aaaaaagcaa tgtatgggtc tccccgctac attgcttttt ttatagctgt tatctgtttt 3073381 tccaaacgtc agcgatgatt tcaaacgaac gcattctgtc tgcgtgttca aaggtttctg 3073441 agttaaccat aatttcgtca gcctgtgtcg ttttgacgaa atcttcaagc ttcgccttca 3073501 cttcttccgg acctccgaca atcgtggagc tcagctgctc attgaccatc gctttttcat 3073561 acgggctcca gatttggtcc atatcctcaa caggcggttt aagctggtta ggcgtaccgc 3073621 ggacaagatc aagaaacctt tgataatggg aagtcgcaag gtgctgcgct ttctcgtttg 3073681 tatctgccgc gataatggtg acaccgacca tcgcatacgg ttcgtcgagc acgtctgacg 3073741 gcgtgaagga attgcggtac agctccaaag cgggaaccgt attcgccggt gagaaatggg 3073801 ccgcgaacgc aaacggaaga ccaagttcgc cagccagacg ggcgctgaag ccgcttgagc 3073861 ccagcagcca aatcggcaca tctatgccct ctccgggaat ggcgcgaact tgattgcgca 3073921 catttcctga cggtttaaaa taattgcgca gttcctctaa ttgttctgga aaatcctccc 3073981 cgctgttgat gtttctgcgg agcgctctgg ctgtcaattg gtctgttccc ggcgcacgtc 3074041 caagccccag atcaatccgc ccgggataca gtgtttccag tgtgccgaat tgttcagcaa 3074101 tgactaatga agagtggttg gggagcataa tgccgccgga accgacgcgg attttcttcg 3074161 tgcctccggc aatatggcca atcaaaactg cggtggcaga gcttgcaaca ccttctatat 3074221 tatgatgttc agcaagccag taacggtgat agccccattc ctctgcccgg cgcgccaagt 3074281 ccatgctgtt tcggaatgat tctgcaatcg ttcctccctg aacaaccgga gataaattca 3074341 agacagaaag caaggtatct ttgcgttggt tgttagacat attgttctcc tttgcaaatg 3074401 tgttatcagt aaacagccca aagctgtcag gtcatgattg aaagaacttc tatcacacca 3074461 taacacaact gcattcagga ataaaagaat ttgattcgat gaaattcgaa caatataaaa 3074521 cgaacggttt ggaacattat tctgctccaa acaactcctt agccatctca ataaagagct 3074581 tagccgccag agaagcctcc tttagcgacg gaacagcaag ctgcacatca cggtatacct 3074641 gcgggtccaa ttccctggtc accacatgct ctggcagcgg catccccgac atggacattt 3074701 ctgataaaat ggccaggccc aggccttctc tgatcatact gatcgaggtg ttgatgttat 3074761 agaccgtgaa agctgggtgc agcgtagcac ccgcctgcct gaacatatcg ataaatggtg 3074821 attcatagcc gccgtcacag acgatcatcg gttcatggtc aagatctttc agcgtaatgg 3074881 ctgaatgact ggcaagcggg tgatcgtccc tgagcacgac agccattttg tcttttttca 3074941 aatgaatgta ctccatctcc tctgttggat acagaagaat cccaacatct atcatccgcg 3075001 tatgaagcca ctccttgact tcatttacag ttccctcgtg cagcacgagc tcaagtttcg 3075061 gatatttttg tttaaattca ctgatcagct tcggcataaa ataagccgag gcagttgaga 3075121 atgtgccgat atggatcgtt cccagttcaa gccctttttc cgctgctgct acctgctcaa 3075181 ctttttcaat gccttttaag acttctctga tgtgtactaa gatctgtttt cccgtatccg 3075241 tcagcatcag gccattgcgg cggtcacgaa tgatcagctt tacatcaagc tcagcttcga 3075301 tcgcagaaat cgcatggctg acagccggct gtgtcatgtt cagcgcctga cccgcttttg 3075361 taaagcttcc cgtttcagct attttcacaa aaacctttaa ttgagtaatg gtcataacaa 3075421 tttacttatg ctccttataa aaaagattca ttttatttat cttatgttct accgtatcat 3075481 atgatggaaa agttctacaa ggagtgaatg aacaatgaag cagctcccaa aaacgcggac 3075541 agctctcctg ctcgcatttc tcgtcatcat gtggggcgtc aattggccgc tgtccaaagc 3075601 cgcgctcgcc tattctccgc cattattgtt cgcgggcatc cgaacgctga tcggcgggct 3075661 tttattagtc atagtcgcac tgccgcgtat tcataaatta cgcttaaaag aaacgtggcc 3075721 gatttatctt gtttctgctc ttttaaatat tacattattc tacggcctgc aaacgatcgg 3075781 gctgaattat cttccggccg gcctgttttc tgcaatcgtc ttcttccagc ctgttctgat 3075841 gggtgtattt tcttggctgt ggctcggcga atccatgttt gtaatgaaag tgattggcct 3075901 catcctcggt tttgcgggag tagccgtcat tagtgctgcg ggctttggcg ggcatatttc 3075961 tgtcattggg gttctgctgg ctctcggctc cgcagtcagc tgggcgctcg ggacagtata 3076021 tatgaaaaaa acaggcagcc gcgtcgattc catctggatg gtcgctctgc agctgacgat 3076081 cggaagcgtg tttctgctta tctccggctt ttggacagaa agcttttcgg cgatccaatg 3076141 gacagctccg tttattacga gcctgctgtt catctccgta ttcgttatcg cactcggctg 3076201 gcttgtcttt tttacgcttg tcggttcagg agaagcaagc aaggtcgcat cttatacttt 3076261 tttgattccg ctcatatcaa tcgtggccag ctccattttc ctgcatgaac cgctcaccct 3076321 tagcctcttg gcagggctgc tgctgattgt cacgagcatc tgtctcgtga atacaaaatc 3076381 aaaagcgcag aaagctgcgg cgattggtat aaacgagaaa gctgcacaat aataaaaacc 3076441 ctcttgccgg atgcggcaag agggtttctt atttactgat gcttgcgtcc tttgaccaaa 3076501 tatgcaactg taatcaaaag gtagatcgcc gcagtaatgc cggtaatgac aattgatgtt 3076561 gtcatgatga ccccgatcag aatggcgagt aatgccacaa tcgcaaacca tgtcgtgtac 3076621 gggaaccatt ttacataata ggccggtgtt tccgtttgct gttttctcga ttttaaatga 3076681 gcgaatccga tgatcagcca aatgaataaa acggtatatc ccaatgatcc cattaaataa 3076741 ttaaatgttt ggcttcctgc gaacagagaa atcaatacgc caatatagag agaagaagtg 3076801 cacatcagaa tcgcaaacat cggtacgttt ttcgatgaaa gcttcgagaa gacctttgga 3076861 agccttccgt cacttgcctg tgtatacaaa atgcgtgatg atccgtataa acctgaattc 3076921 atagaagaaa tgatcgccag caggatgact gcattcatga tatgatccgc gcccggaatg 3076981 cctaccattt taaagaccat cacgaaagga ctttccggaa cggaattgac ttggttccat 3077041 ggaatcaggc tgacgatgat gaaaaacggc agcaggtaaa acgcgacaat ccgtgtcagt 3077101 gtgctgcgga cagctttcgg gacaaccttt tccggatttt ttgtctctgc aagcgttaca 3077161 ccgataattt ctgtaccgcc gtaagagtag atgacgacaa gcatcgccgt gatcagccct 3077221 gtgccgccgt gcgggaaaaa tccgccgtgg tctgtcaggt tggaaaatcc ggatgctgta 3077281 tgatcaccga atgatacaaa taagagcagc aatcccagaa taataaagat aataataacg 3077341 gtaatcttga tcattgccag ccaatattca gtttcggcga agattttaac agaaagcaag 3077401 tttacaatcg tgacgataag agaaattcct aatgccaaca cccagatcgg gcagcccggc 3077461 agccaatatt gaatgaaaat cgcagctaca acagcttcag ccgcaatgtt aagcacccac 3077521 attttccagt agatccagtc caaaaagtaa gcagcgtaat ttcccaatac ctgctggaca 3077581 agatcacgga aggttctggc gttacggttt cgaacagcca tttccgccag cccctgcata 3077641 ataaacagca aaataatccc gccgagcagg tatgcgataa tgacagatgg ccctgccaca 3077701 tcgatcgctg agctgctccc cttaaataaa cctgcgccga ttgctccgcc cagcgccatc 3077761 atcataatat ggcgggacgt catcgtgcgt tttaacgttt gattgtcgtt tttcatcctc 3077821 ttctacctct ccttctcgtt ttcaaaaaca aaaaagcccg ccgtctccta cctaatctaa 3077881 tagataaaga gacgacgagc cttcggctga ccgcggtacc actcttgttg attcttcatg 3077941 aagaatcctg cttttgacct gtaacgaagg ttagccgtta aaacataggg aatattcaat 3078001 ctattccgtt ccgtcttacc actcccgggc gagttcaaag aagaatcagg ctgcgtcgca 3078061 ccaccccgca gctctctgtt ctgatcactt tcttttactg ctcccaatct atgtgtttta 3078121 gttttctgaa aaactcaaat tttatgatct gaatatatta acataatata cgtgcttctc 3078181 ttttaactgt caataacttc agagaaaaaa gaaactgtta ttttgtccct tttcgaatgg 3078241 ctttccaaaa ggattctgac tcgtttccta atgcgtaaac tgaaacacct gctattttat 3078301 attgctttgc cagatggctt ttcgtttgaa cggttttttc gttttcatac cacacgacat 3078361 gtttatgctt ctttttgtca acataagaaa acgtcatcga gcctgatttt ttgttgaatg 3078421 ccggctttgc tttttgtttt ttgatgaggg atttgagctc attccattcc cttattgtgc 3078481 tggtacttcc gtcttttaca tcccagtcat agccgtacgc agggattccc atgatgactt 3078541 tattggcttt gatctttttg actgaaaact gcagagagct tttgatccag tttgtgcttg 3078601 ccactgaccc cggctcaccc caaatgccgt gttcatcgta ggtcatgact tgtacgaagt 3078661 cggcatattt gccgattttc gcataatcat acggccagct ccagtcatca tttttatcat 3078721 cggcgctttt ggccggaacg gataccattg ttttaatatg tttcttattc aaagcctgtg 3078781 agacatattg aatgaagttc gagtatgcag cgcggtcttc tggatttact gcttcaaaat 3078841 cgatattgat tccgtaatat gagtgctttt tggccagtgt aattaactga tctgtgaatc 3078901 gttttttcgc tgttttattg ctcatgaccc gactcgctaa atctccgtca aaatcataaa 3078961 tggcatcatt atagtttgaa atgacagccc atgtcttgat ttttttcttt ttcgcatatg 3079021 tcagctgctt agttggggca tcgccaatga tttgtccgtt tttttcaaac gcaaatgtat 3079081 cggttgcgat ggcattcatg tatgtatgat atttcgtaag agaattgtat gaagccgtat 3079141 ccccagtcgt gtagcctact gtcataccgg ctgccttcgc ttctcctttt gtatacataa 3079201 acagaacaat cgcaatcgcc agtgaaaccg ctatgatcag ccattttttc atcgcatttc 3079261 ctcctgtatc aagtcatact cttctcatcg gccaaaaaat tggaagttga agttttttca 3079321 agcaaaaagc ccggcatatg cctgccgggc ttcctgagtt cagcggtcag agacgagaat 3079381 atatgctgcc tttactggtc catgcacccc cacaactaaa tccatttcaa tgtcggctga 3079441 gttactcggt ccggtaatgt agttgataca tgaaggaaca gtgacaccgt tcgcaatgtt 3079501 ttggcggatg atatcactgg cttgtgtcat tctcggtaca atgcttgatt tcggcacgat 3079561 cgcaatataa gtcgttggca aaaggctgac agagcggccg atgtcttttg aggagaagag 3079621 gacaaccgtc cccgactcag ccaatgtaat ttcgctgaat gtaatcccta cattggcttg 3079681 ctccgctttt ttaatatttt cctcgccttt gtcagcatcc cactcccaga ccggcgttcc 3079741 ttcactcggc cagtccttgg tgagcaggct tttcagtccg tattcttcaa agcgggggtc 3079801 cttcggaatg atgacagggc ctccagaaaa gcggctgact tgctcgcgca gggcatcgta 3079861 aaggccggtt gaatccgttt caatcagctc tgtatggatt ttgacacaat ggtttttgag 3079921 cactgtgact aagtcatccg ctgaataacc ttcaagtgtt ttatattgcg gctgatgcgc 3079981 ccattcaggg actgccacgc ctcctgttct tcgttcacgg cccaggctgg atgcgattcg 3080041 gtttaaaaag ctctcttgat tctgaatggt tcccttcgtc atcactgctc ctccttcgtg 3080101 cgttcacttg tttctctgtc cgcaaaccag tctctgaatc tcgatttatg cggtgccggg 3080161 aagtcgcgaa tctgggtcca atttttaagc gggccgggcc ctttcgaaat tttttcgtcc 3080221 tctgtaaaag gcgtcatggc ggccggcgcc cattttgagc ccattttgta aagcgataag 3080281 gaggatgcgc caagtccgaa tgctttcatt gcaagctttt cactgatcgg cgccctgcct 3080341 tctttttcga cgatattctg acgatgcttg agtagcagct catgaagcgg gattttgacc 3080401 gggcaggctt ctgaacaagc agcgcacagt gaagatgcgt acggcagctc cttataatcg 3080461 tcataaccgc cgagcaacgg tgataaaaca gctccgatcg gccccgagta gattgagccg 3080521 tatgaatgtc cgccgacatg gcggtacaca ggacagacat tgatacaggc ggcacagcgg 3080581 atacattgca gcacagactg gaattccgtt ccaaggatat tggatcgtcc attatcaacg 3080641 atgacaagat ggaattcttc cggaccgtcc acttcacctt ccagcttcgg acccgtcaaa 3080701 gctgtaatat agcttgtcag ccgctgtccg acagcacttc tagtcagcat gctgactagc 3080761 acttcaaatt cagaaaatga cgggacaatc cgctccattc ccatgacggt aatttgtgtt 3080821 ttcggcaagg tgctcacaag ccgtccattt ccttcattgg tcacaaggct gacggaaccc 3080881 gtgtcagcga tggcgaagtt acagccggta atgccgatat ccgcttccag aaactttttc 3080941 cggagaatgg cgcgcgcatg catcaccagc tcttccggtt tttctgtatg ttgatagtcc 3081001 agtctttctt taaacacatc gcgtatctgc tctttatttt tatgaagagc gggcgctacg 3081061 atatgtgacg gcggatcgtg atcatcaatc tgcaaaatat actcgccgag atcggtttct 3081121 acgacttcac agccttcctt ctccagcacc tcattcagat tgatttcctc tgtgaccatt 3081181 gatttagatt tcacaatttt cttcccgttc ttcttttgaa tgacatcccg aatataggaa 3081241 gacgcctctt ccgctgtttt cgcgaaatag acatgtccgc ctcttttcgc cacattttcg 3081301 gcaagctgtc cgagatagaa atcaaggttt tcaaggacat gctgcctgat ttcctctgat 3081361 aatgagcgcc actcctccca gtttcccagt tcttctgctg cctctaggcg ccgcgtccgc 3081421 agacgctcct gtgcacctga aacagcgcct ctcataaatt cattatcaat cccctgtgat 3081481 acccgctctt taaaagcgtc agtaccgatt ttcatcgcca tgatcctttc cccctctgaa 3081541 tccagtttta tctgctgttg agcacttcgg cgatgtgcat cactttgaca ttcttatctt 3081601 ttcggccaag ccgtcccccg atattcatca aacagccgca gtcagcaccg atcagcacct 3081661 ctgctcccgt ttcctccaca cattcgactt tttcatcgac catctgctca gaaatctgcg 3081721 ccatcttgac tgagaacgtt cctccgaatc cgcagcagtt atgtttgccc ggaagctctg 3081781 taaactgcag gcccttcaca tggctcaaca gcttcatcgg ctccttccga acacccagca 3081841 gcctagtcat atggcacgac gtatgtaagg tcgcttttgt atgaagggtc gcgccgacat 3081901 cctctacccc aaggacgttc acaataaaat ctgtcagttc atacgtttta tccgccagct 3081961 ttttcgcttt atcggcccat ttcggatcat cctgaaacag gtgcggatac tcccggaaca 3082021 tcgttgtgca ggaacccgaa ggactgacaa catattcgga atcctgaaac gtttcgatca 3082081 tccgtttcat tgcttttttg gcgtcatgta catagccgct gttgtaagcc ggctgtccgc 3082141 agcaaatctg cccttctgga aaatcaacct cgcacccaag ccgctccagc agctcaaccg 3082201 ttgcttttcc gacatttgtt tgaaacatat caacaagaca agtgacaaaa agtgagactt 3082261 tcatgatgaa cccctctctc atccccaata tatgatcagg tcatctgatg acctgagtta 3082321 aaataactat atgaatatcg tacactattc tgacaatgga aggaaagagt tttctaggga 3082381 tattttcatt tgtggcatat caaaaacact cccgatctcc caggagtgca gtatatggtt 3082441 agatccagcc cttttcctca gcgatgctgg cggcttctgt ccgatttttc gcattaagct 3082501 tttggatgat ttctgagata tagtttcgaa ctgtgccttg agataaatag agctccagcg 3082561 taatgtcttt tgttgtcttg cctaaagccg caagcctcag aatttcttgc tctctaacgg 3082621 ttagcggatt ttcgtctcgc atcatattaa acgtcagctc agggctgaag acacgttttc 3082681 cctttacaca ttttcgaatg gcatcggcca gatcgtcaat ttcaccgtct ttcagcagat 3082741 agccatgtgc accggccttt acggcgcgtt caaaatatcc ggggcgggca aaggtggtta 3082801 aaataatgac cttgctgacg cagccttttt tcattaattc ctctgccaca ttcagcccgc 3082861 ttcgaaccgg catttcaatg tccataatgc atacatccgg ctccagcttc aaaatagcat 3082921 gtagcgcctc ttccccgttt aatgcttgtc cgatgactgt catatcctct tctaaatcaa 3082981 gcaaagatcc caaagcgcct aaaagcattc gctggtcctc agcaataaac agacgaatca 3083041 ttcttttcgt cctccaatca ttctgctttt ttaataagcg gaatcgtcag tgccacaacc 3083101 gttccgttat ggtctgaaac cgttaatccc ccttcaatga gcatgagccg ttcttccatt 3083161 ccccacaggc cattcccaaa cattttctcc ttcggcgctc cctttccgtc atcccgtatt 3083221 acgatcctca ttttgtcagc aaattgagaa atggtgatgg cacagtgggt tgctttgctg 3083281 tgcttgataa tgttagtcac ggcttcccgc atacacatac tgataatatt ttgagtgacg 3083341 ggagatatca ctgaaaagtc gtcggctcct tcgtattgaa aggtaatgtt ccccgctctt 3083401 aatatgtgct gaatgtttac gagctcctct gttatcgtga ccgttctcat atcagaaacc 3083461 agctctcgaa cttgcttgag tgcggagcgt gaactggttt ccatttcttt tgcctcaagc 3083521 ttggtccgtt ctggatcaga tgcagccagc cgctgaatga gctggctttt taatgtaagc 3083581 agcgacaggg tgtggccaag agtatcgtga agatcacggg cgattcgaac acgttcctcc 3083641 cttttagaga gttcttttat ctgttcgttg gcttgtgcaa gcttagcttc aagctcaatc 3083701 ctccgaaaca tagaacgaat tccgaatgga gaaatgagca taatgacgag aaacgggaga 3083761 acagaaaaaa gctcccgaag cgagaccgaa ttcgcgataa attggtatag gcatggaaaa 3083821 agcagtataa agattaaagc gcagaacgca cggttaaaat tcgttttctc tttgtaataa 3083881 ccaacaaagt ttgccggaaa aaaacctaag tatatatagg tgatattgta aaacacacta 3083941 tacatcaaaa taaccgccat ttgcacgata agccaatatg taaacgaagc tttgcccacg 3084001 ctgcagaata actggcgata tgccgctaca aaaaggagca gcataccata tccgatcccc 3084061 tgtttgaccc ctgattcttt taataaagag aggaacggca taatcgtata caccagaaag 3084121 atataaggga aaaacccgaa ttccttcggg aaaatagata ttgccttttt catgtattac 3084181 accgcttctt gttttcttct tatatattta gatagtagca tgaagagcat catataagcg 3084241 attaatatca gaatattttt ccaagtcgga ctcccacccc ggacaagttc ccacgctccg 3084301 ctcccgaaat gataagacgg aagccactgg ccaatgctct gcatcatgtc aggcatgacc 3084361 tcaaacggca tccacatccc tccgcctaaa gccagcagca tataaagcac attactgatt 3084421 ccggccgctg tttctacttt tctcatgagg ccgattagtg tgcctaatgc taaaaaaggc 3084481 aatgcgccaa acaaaatcca cagtccgctc atcatccatt caaacggtga caaggcaata 3084541 tcattgatga ttgcgccgaa cagaaatatg acggtaattg ataaaacgtg aatgacactt 3084601 tggccgatca tctgagctga taaatagata tgatccggaa gaggcgtaag gcggataaag 3084661 gcggcccagc cttgtgaccg ttcttgtacc attcggatgc caagcgtcat gatagaggaa 3084721 cccatcacgc tgaagactgt catcgacatc aggtaatggg cttcccatgc acgttgatca 3084781 gggacgttgg tattcactac atttgtaaag aaataataaa aggcaatcgg catgatcaga 3084841 gaccaaagca caaagtactt gttcctaagc acccttttca tttcagcgat gctttgcttt 3084901 tgcagcacgt tcactcacat cgcctccctg ttgccgtcag ccagctggcg aaatgcctca 3084961 tcgagcgttg cttgctcaat tcgaatatcc cgtgcatgta tgttttcttg aaagatcagc 3085021 gccaacactt tgtctgtatt tgatgtctgg atgatggttc tctcatgctc gtggatcact 3085081 ctctcgactt ccgggtgaca agacagcctt tccaatgatt cacttgaatg aagcgtaaag 3085141 gaaacagact gtttttgaat tcttgagcgg atttgcattg gtgagccgtc tgcaacaagc 3085201 tgtccttcag taaaaaatag gattcgctgt gcggcatcat ctgcttcctg taaataatga 3085261 gttgaaaaaa taatcgtttt tccttggtcc gacagtccgt gaatggtctg ccagaatcgg 3085321 tgtcttgatg aagtgtccat gccgactgtc ggttcatcaa gtataagcag ctccgggttc 3085381 ccggcaagag ccaaagcaaa gctcaaacgg cgtttttgtc cgccggataa tttttctgct 3085441 cttgttttca aatcttcttt ggtgagtgct gttaacgaaa cgagttcttt catggacaat 3085501 ggattcggat aatagctccg gaagagttca aggatttcat ccaccttaag gcccggcatg 3085561 acacttactt cctgaagcat tacacctatt ttttcacgaa cctgttgatc atcgggaacc 3085621 cggttaaata gtttgatttc tccctcactc ggtttcagca atcctaatat catcgagacg 3085681 acggtcgtct tccctgcccc atttggcccg agaatggctg caatttctcc tttttcaata 3085741 ctgaagctga tgttgtttac agcggttttt cgctggaaat gttttgtcac gttgcttact 3085801 gttactgctt ctttcatcac atgagcacct cctgatcgtt tacattgatt gtaaaatgac 3085861 ggagaagacg atgttagtat ggggtgtcat gatgatggag tgacaaatgt catttttttc 3085921 tcaccccggt gtctaggcaa tcctcctcct gcatcttcca attcatccat cttttctatc 3085981 tcccatgtcc tctttctttt aaactgctgt gacattcata gaaagataca ctcttcaaac 3086041 catccgagtg ttatgataga aatattgaac tttatattac tttccggctg aaaggagcca 3086101 atcatgaacg aagcgatttt gtctagaaat catgtgaagg tgaaaggcag cggcaaagca 3086161 tctatcatgt tcgcacctgg ttttggatgc gatcaaagcg tgtggaatgc cgtggcacct 3086221 gcctttgaag aagatcatcg ggtgatttta tttgattacg tcggttcggg acattcagat 3086281 ttgcgcgcat atgacctgaa tcgttaccag acacttgacg gctatgccca ggatgttctt 3086341 gatgtttgtg aagctttaga tctgaaggaa accgtgtttg tgggtcactc cgtcggggcc 3086401 ttgattggga tgcttgcatc catccgccgc ccggagcttt tttcccatct ggtgatggtg 3086461 gggccttctc cttgctattt gaatgatccg cctgagtatt acggaggatt tgaagaggag 3086521 cagctccttg gcttgctgga gatgatggag aaaaattata tcggctgggc gactgtattt 3086581 gcggcaaccg ttctgaatca gccagatcgg cctgaaatta aggaagagct tgaaagccgt 3086641 ttttgttcta ctgatcctgt cattgcccgc caattcgcga aagcggcgtt tttttctgat 3086701 caccgagagg atctttcgaa ggtaacggtt ccctctctta ttctccaatg tgcagatgat 3086761 atcatcgcac ctgcaacagt aggtaagtat atgcatcagc atctgcctta tagcagtctg 3086821 aaacaaatgg aggctcgcgg acattgccct catatgagcc atccagatga gacgatacag 3086881 ctgatcggcg attatttaaa agcacacgtg tgatatagga acgaaaggga tagaggtgac 3086941 cctcttagat ggacaaacaa ttgaatgatg caccatgcgg tttcctcgct ttgtcagaag 3087001 aggggtcgat catagctgcc aaccgcaccc ttatcaagat tctggattat gaaccggagc 3087061 aggttatcgg ccagcacatg aatatgatgt tgaccattcc cgcgcagctt ttctgccagc 3087121 tttatttttt tccgcttttg aaattggagc atcacatcga agaaatatac atttccctga 3087181 aagcaagaga tggagaagaa attcccgtcc ttatcaatgc tattgcgaga cacgatagcg 3087241 gggcttctgt ctttgattgt gttctgattc caatgcgaaa gcgaaatgaa tatgaaaatg 3087301 agctgctgat agccagaaat gaggctcagg aagctttgct tgccaaacag aaagccaatg 3087361 cggagttaga aattgccttg gaaacgctga aagcaaaaca agaagaactt cttgagatca 3087421 ataaacaaaa tcaacaattt aaattaaaca ccaaaagaga gcttgaactc gccagaaaga 3087481 tccagaaaaa ctcgttgact gaaccgattg taaacgatca ggttcagatt gactcttatt 3087541 acaacgcatc gagtgaattg tcaggtgatc tttacggata ttatcaaatc gatgaacacc 3087601 gttacggcat tattatcctt gatgtgatgg ggcacggaat ttcatctgca ttgattacga 3087661 tgtctcttca tcctttgttc cagcgccaga tcacgcaagg tctcagcccc gttaaagtta 3087721 tgaaggaatt ggaccggcac cttcacagct tgtttcaaaa tgatgaggaa gcaagacatt 3087781 attgcactgc tatttatctc gagattgata tagcacggca aagaattgat tatgtcaacg 3087841 cagggcatcc gccggcactt tggcaggacg atagcggaac tcaacatctg cttcacgcga 3087901 cctcgcctcc gatcgggatg tttgaagact tagagtttca gtcaagcagc ctttcataca 3087961 cggaggacgg aagattgctt ctgtatacgg atggcgtgat ggatcctacg gcttcatgtt 3088021 atttatttga tttactaaag gatcatcctg attcgccaat cgctgacctg aaggagaaaa 3088081 tccttacatc actgcagcat caaaaggaag ctcatcataa gagtgatgac gaatgtttta 3088141 tattagttga tgtaaaataa aatgatccat gagacataac aatgatttgt tacatctcat 3088201 ggattttttt gtttcagcgt ttctttggaa tatgtcctga ctccgcatat tgaaacacct 3088261 gcaaggaagg cagcgggtgt ccattaaaat caaataaagc ttgattatct acagcacttc 3088321 ccccatacca cttcccggcg tcttcagggt cgtattcagc agcatagctg gacgcccacc 3088381 ctgacccgta tgtttcccat aacactttgt ttttctctat ctgtgtcttc ggcccgactg 3088441 gaatccacgc cggctcccag tagaaaacac caagtcctgc tttgcccgta ttcgccactg 3088501 cctccattac atctcttact gcagttgcct ggccttgaac agaaattgga tatggcaacg 3088561 tctgcccgct ttttggtgct gtatttccat gcccatcgcc atcctcagcg gtataggtgt 3088621 acgatgtctc cgccaccatg acttttttgc cgtacgtatt ggcaacagcc ttcagcacgg 3088681 aggtcaaatt ttgtaatgtg ccatgccaga aaggataata ggagctagca aacacatcat 3088741 aatccacttt gtttttgctg agtgtttctg caataaatga ataccttcca gccgtttcag 3088801 gattggtaaa atgcagggcg accaaaatat ttgaatttgt ctccctgacc gctcggcttc 3088861 cttcattaaa taattggcac atcttcgtcc aatcagtctc accggcaaat cctcctgttg 3088921 tttcatttcc gacctgaacc atgccgatgt caacgccttc cttgatcatc ttttgcaggc 3088981 tttgtttcgt atactcatag agctttgctt tttttgcttc aaagctgaga ttcgcccagg 3089041 ctttgggcac cttttgtttc gctggatcgg cccagaaatc agagtagtga aagtcggcca 3089101 gcaccttcat tccgttcgct gtcgctcttt ttccgatttc gatggctttt tgaacatcat 3089161 tgtttccccc gccatacccg ttgccatttg aatcatacgg gtgattccag atgcggacgc 3089221 gaacatagtt gaccccagcc tgttttaaag ttgtaaagat atcctggcgt tttccgtttg 3089281 tattgtaaaa ggtgacaccg ctgttttcca aagcaataac gctggataca tctgcccctt 3089341 tgataaaatc cttgttcatc ccctctactt ttttaacaaa aagatcctct gcccgaagct 3089401 ctgacacgtg cttctccttc tcaatggcag cggcatatcc tgttgaacta catgcactcc 3089461 acacgatggc agccgcaaag aacattttca ctttgctttt catgatttca tccccccaag 3089521 acttagcaag cgttttcatt ctatagaaaa aagaatccgc ccatatcgag cggagcatca 3089581 gcctaatgtg tgtttacgac aattctcact tcatactttt ccatcgtcag gtcgcctgac 3089641 aatatgtctc ctgtcattat gtccttcaca ctctgatcaa acgtgaccag ctgtttttct 3089701 tccgtgaaat tcatgacaaa aatataatca ttgtcctgat cctgcctcgc ttgtacggag 3089761 acgccttttc cgtgccgaac cggaaaaact ggagagagag acaggtctgt gatcagaccc 3089821 tcatagaaat cacgctgaaa ttgatcctcc aaacgcgcgc cgataaaata cgccttgccc 3089881 tgctgatact catggcttgt gaccgctggc gtgcgcgcat aaaaatcttc ttgatacacc 3089941 gcttccactg aagctgtctt tacatcaatc acggttgcat aatccttcat ttcatatatt 3090001 tggctgcggt agctgacagc gtttcgatcc ttcggataca gggtgtccgt ttcaagaggc 3090061 tcaactccaa atatagcttg aagatccgga tgccatccgc ctgtgtatgt taagtcatgc 3090121 tcattcacaa ccccgctgat atacgtcatg actaaggtgc cgccgtcagc cgtaaacgct 3090181 tttaaacggg aaacggtgtc ctcgctgatt aaatacagca tcgggacgat cagcagttta 3090241 tatggtgaaa agtcttgttc tttcgtgatg acgtcgacag ggatatcgtg ttcccagaat 3090301 gtgcggtaat gctgctgaag cgtttgcgga taacgttttg tcgccttcgc aaacccctga 3090361 gcatcctcga gcgcccaatg attttcccag tcatataaaa tcgcggtttg agccggcctc 3090421 ttcgttccga caacttcgga cagccgttcc aatgtctcgc ctaccttggc cacttcttga 3090481 aagacgcggt tcttcgggct attgtcatga tccacaaccg ctccgtgtaa tttttctgat 3090541 gacccccgtg atttgcggta ttggaaatag agaacgctgt ccgagccgtg ggcaatcatt 3090601 tgcatggatg acagcagatt catgcccggg cgctttgcct tgttgacgtt atgccaattg 3090661 accgcgcttg gcgtacactc cattaataag aagggctgct gcttcaagct tcggtacaga 3090721 tcattgataa agccgacctt catcgccaaa tcagctgtgc tttcccagtc attgtgccag 3090781 acaggataag cgtcccagct gatggcatcg acatgctttg caaatttgct gtagtcgagg 3090841 ccctgatacg ggatcaaatc cggtgtgtca gccataaaat tcgttgtgat agggatatca 3090901 ggcgtcaatt ctttcagcgg aatgatttca ttttcataaa acgaaatcgt ttgatcggtg 3090961 acgaaccggc gccaatctaa attcaggcca tgcaagccat tttcaccgat cggcgaaggg 3091021 ctttcaattt gtgaccagtc attgaacgta tggctccaaa aaggggtcca ccacgcatgg 3091081 ttcaatgtct tgaggctgtt gtcatatttc gatttcagcc actcccggaa agcatgctgg 3091141 cataaatcac agtggcaatc tcccccgtat tcgtttgaaa tgtgccacat taacagcgcc 3091201 gggtgatgtc cgtatcgttc tgctaataag cggttgatgt gccgtgtttt ttctcggtag 3091261 actttagatg tgaggcagtg gttgtgcctt ccgccgtgca gctgtttgac gcgggaggca 3091321 ttgacgcgca aaacttccgg ataggtttgc gacagccagg ccggacgggc tccgctcggc 3091381 gttgctaata tgacccggcc gcctatactg tgaatccgct caaaaatatc atccagccat 3091441 tcaaattgat atacgccctc ctccggctca agtgcgctcc atgcaaaaat gccgacagaa 3091501 aacgtattcg tatgagaaag cttcatcagt ttgatatcgt cagctaaaat atcgggccga 3091561 tccagccact gatcggggtt gtagtctccc ccatggagca taaattttgc ttttgttacg 3091621 tgcgtttttt caagctttga catcacattc tcctccttgt tctcttagcc cttcgttccg 3091681 cctgcggtta atccggacac aaaattcttt tgcagcataa taaagatgac ggcaaccggt 3091741 atgctgataa gcagggctcc ggccgcaaat gtcgtatagc tggcccccat gacatcattc 3091801 actaaattga atagaccgac gggcaatgta tatgattcag gcgttctcaa tatggttgag 3091861 gacagcacaa aatctccgag cggaccggta aagccgttca tggccacgac tgccgccatc 3091921 ggttttgata atggcagaat gatctggaag aagattctgg tgctgctggc tccgtcaatc 3091981 ttggcgcttt cgtctaaatc catcggaatg gaatccatgt accctttcat caaatacgta 3092041 ttcatcggga tcaggccgcc gatataaagc aagattagca gccagtggct attgatcatt 3092101 cccaagattt gcgccagcac aaacaaggca attaaagctg aaaactgagg aatcatctgc 3092161 agcaataaaa agagcgttaa agcgtatttc ctccctttaa accgaaagcg cgaaaacgca 3092221 taggccgtaa acgtcacaca gagcaaagac cctgccattg taaacaggct gatcttcata 3092281 gagttgacat accactgcac atattgaagg ctttccttgc ccgcaaataa ttccttgtaa 3092341 tgatcgaatg tcggatgctt cggaatgatg gatgtactga ttaagctgtt gccgggatta 3092401 aagcttgcgc ctgccgtcca aaggagagga taaacaatga tgaccgccat aaaggctagc 3092461 aacaagtaag agaaaaggag acggatatat cttctgactt tcatatctgc cagcatacct 3092521 tatgcctcct ctttaaaaga ctttgtctgt ctgaactgcc acaatgcgat ggagataaca 3092581 aatacagata ataaaatggt taaagccgca gcaagtgaat attggctgga ctgcattgtc 3092641 aatttataaa tccatgaaac gaggatatct gtcccgccgg ctgttgatcc ggttacagcc 3092701 ggacctccgc cattgaatag atagataata ttaaagttat taaagttaaa cgtaaactga 3092761 gtaatgataa tcggagccat tgcaatgaac accatcggaa gcgtgatgta tctcagcttt 3092821 gaaaagacag aagcgccatc aatcgtagct gcttcataca gatcgtccgg gatggattgc 3092881 aatacgcctg ttgagacgag aaagatgtac ggaaatccga gccagccctg catgagaatc 3092941 aatgcaagcc tcgaccaatt ggcatctgtc atccacggaa gcggatctat cccgaagaaa 3093001 gccaagatgt cgtgattcat cgcaccgaag ctatcattaa acagtcccgc aaaaattaaa 3093061 atcgtcacaa aaccgggaac ggcccatggc aaaatcagaa tcgtccgaaa aaaacgttta 3093121 aaccgaaggt ctttctggtt aacaatgatc gcgagaaaaa tccccaaggt gacttgcagt 3093181 gtggatgcag caagtgtcca aaccaccgtc caagccagta catcaaaaaa agtcgacctc 3093241 caaatatcaa ctgtgaaaat atttgcgaac gtttgaaaac cgacccaatc aattaatttt 3093301 gcaggaggag aatgatacaa atcatagttt gtaaacgcta atgcaaagct gaataagata 3093361 ggaaagatca cggcgaaaat taaaataaac aaagatgggc cgctgacgac ataaggatag 3093421 ccctcagaaa tgatatgctg gtattgttcc tttaaggaac ttaatggctt attttcatca 3093481 cgctgttttc cgctttggaa cgcatcgcga agatttacat aatacaccgc aaggccaaag 3093541 caggtcacga tgacagcaat aatcccttcc gccagcagaa aaacggaatt atcccgcggc 3093601 acttctgttc ccagtgtaaa gattccccaa aaccccatat tgagcagatc tccaaagacc 3093661 gcaaaaaacg atgcgcctaa gaaaagaaag acaatacctt ttatccattg cttgttataa 3093721 aattgcccga gtcccggaat gatagaaagc aacaaagcga cttgacgatg ctgcaccgtt 3093781 ttcacctctc ttacaataca aatctagctt tctctttatt ttccgctgtg ctttgcctta 3093841 atttgtcctt tggccgtttc agctgcttga tccaatgctt gtttcggatc tgccttccct 3093901 gttgcaaccg tctgtaatgc tgaatcagcc ggcgtccata tttcattcat ttccggaata 3093961 tttggtgttg gctctgagaa acgggattgt tcagtaacag cccgtgccgc ctcgcttttc 3094021 ataatagccg ggtcattggc tagggatttc acagcaggaa cttctttcgt ttcttcatat 3094081 cgtgttttag aatttttttc atttgccagg aaaacggcta attcttgcgc cagctcttca 3094141 ttctttgaaa atgcactgac gttgtagctt ttgacgccga taaaggagct catgtttttc 3094201 ccattttcca gcttcggcag tttcgtaatg ccataattga ttcctgcatt cgaaaaggct 3094261 tctacattcc atggaccaga aataattgcg gcggcttttc cttctgtgaa cagcgattcc 3094321 aacacgttaa tcccttgttc tccaataatg ccagccggga acaggccatc tttgtaaaac 3094381 ttctgaatca gcgccgcacc tttgacagct ccttcattat tgattccaat gtctgacggg 3094441 ttatagctcc catctttggc ctttccaaaa atgtatccgc catatccgct catcacactt 3094501 tctgcataat aaatttgatc gaatagggct aaaaagccaa atttgctgcc gtcagcagtc 3094561 tttttggaat agtcgtacca ctcttccagc gttttgggca attccttttc tgtgatgaga 3094621 tctttgttgt aaaaaagcac agtcgtttcg accgcttttg gcagtccata aagcttttga 3094681 tctaccattt gagactgaat ggaagcgtca gtataaagtg attgaacgtc ttttttgaca 3094741 tgtaattcct tgagtaatcc ttccgtgaca gcggttccga tttggtcccc tggcattgtt 3094801 aacacgtcag ggcctgtgcc ggccggtcca tccattcgca aatcttcaat ctgcttggca 3094861 tacggttttt caacgacttt gaccttcaca tcatgctctt tttcaaatgc agccacagcg 3094921 tctttaatgc cgttgctctt ttctttatcc tcccatacaa caagctctga cccttttgaa 3094981 ctcgatttgg cgctgctgct ttcctttggg ccgcaagccg ccaaggataa actgacagct 3095041 gcgcagagca tgaatacgga acactttttt gccattttca ttgattgtca ccctttcggt 3095101 aggaatgaaa gcgctttaaa gataatatag catgcctgag aaaatgtgta aacaaactat 3095161 ttacttcata gagtaaattt ttttacctaa ataaaaaatg acttagtgtc ctaagtcatc 3095221 cttaattcat actcttcctg acgattaatt ctgcgcccac atataatgtt tttaccgttc 3095281 ttctcttgtc ctgcacttgt tcaagcagta attgaacagc gtttttacat aattcatgta 3095341 tatcaatatg aaacgtcgtc agaggaggcg agacatactt cgcgaagctg atgttgttga 3095401 tactcacaat gcttaccctg tttggtatgg caattccttt ttcgttcagg gcttgcagac 3095461 agcccactgc aatcgggtcc gctgcaatca taaaagcagt cggaagctga tcgcctaatg 3095521 tgtcgatcgc tgctgacatc aggcggtagc cgttttctac agagaatccg cgatgacaga 3095581 aaatatagcg ctcgtccagc atggcttttt ccctcatata ggatctgaag gtttgttcac 3095641 ggatgtccat ttcatcctga ttggtattcg gatttttgta tgtgccgccg ataaaaccga 3095701 tgctcttatg ccccttctca gtcaggatgt ttaccgtctt ccttgtcatt tgtgccaaat 3095761 cgggccttac cgagtcaaaa tgatcgggat caggagttga atcgatgaac acgccgtttt 3095821 cagtgagatt tctgaggaaa gccagctctt catctgaaaa tgtgccgacg gcaataaacc 3095881 cttccgtatg ttcaggaatg ctctcgattc catccgctat tttataagtg gtcatatcga 3095941 cattgaatgc tttcgccagt ttctctactt ctaatctcat cgttttaaaa tagacatctt 3096001 ctaattcttc tttatctgtc agccaatata aaaacgcaat atgtttcacc agcggcctta 3096061 ctgttttttt gcggtaattg agcttttccg ccgcttcata gattttctcc cgtgtctcat 3096121 caggaacaga aaggctttca tcgttattta aaacgcggga aacggttgag attgaaaatc 3096181 ccgcttcctg cgcgatatct ttaattgtcg ccattgtatc tgcctccatt attcagctcg 3096241 cattgtttta gtaaaatatt ttactttctt tttcacaaat gtcaagtgca caaagccctc 3096301 tggctgccat gtaaaaagac tgaaccattt gcggctcagt ctcagttgtt cgtatcattc 3096361 ggaaccggcg gaattgcccg ggaaatgagt tggttattgc acattttcct cgaaatatcc 3096421 cgaaagcaca tcttccacat tcgtcaaatg cgccagcatg gcggcttccg cctgtgcacc 3096481 gttcccggca gccacagcat tgtaaatccg ttcgtgctcc tcatacagcc gctgaacgga 3096541 ggtcttcttg gaaaacagcc agattttcct cgtttccctc attgtttcca gcagcaatga 3096601 tgacacgtga ttcatcaagt gtttaagaag ttcattttga gaagcgtccg caagcgcaag 3096661 atgaaatgca aagtctgctt tctctcccag ctccccgtcc gcttcaatgc tgcccatttc 3096721 ctttagtgca tcctgaattc tttcgagatc tgcttctgtc cttttttcag ccgctagtga 3096781 agccacgccg atttcaagca gttttctgac ctcgagcagc tgcttgacgt cctctttttt 3096841 catcagaagg gcggctgaga gcggctgaga aatttgattg agctcaaatt ccttcagata 3096901 cgtgccttct ccctgtttca tttcgacaag ccccatcgct tttagcgcag aaagtgcttc 3096961 gcgaaccgct gaacggctga cttgaaagct ctcagcaagc gcctgaacag agtccagttt 3097021 atcccccggc ttcaattcgc catttttgat catatctaat agggcatccg ctacttcttc 3097081 atatattttt ttgttttaat ctgtttatat ttcaatgcaa ttcaccccgt aacttgtagg 3097141 tctggctgtt tacgatctat tatactctgt tttgtgggcc gccaaaagat tttgactatt 3097201 ttgtcaaaaa gtcttgtact ttgatttttt tcaaaatata atgctaggta actggtctta 3097261 ttacccagtc atcagatgat catatcatct atagaaaccg cttacatatg gcgccagttt 3097321 atgtttcaag gaggggtttg ggatgcaatg gacacaggca tatacgccta tagggggaaa 3097381 tttgctatta tcagcgcttg ccgcacttgt accgattatt ttcttttttt gggcactcgc 3097441 gattaaacgg atgaaggggt atacagcagg cttggccaca ttggggatcg cccttatcat 3097501 tgctgtattg gtttatcgta tgccggcgga aaaagcgctg atgtccgcga cacaaggagc 3097561 cgtatacgga ttgttgccga tcggctggat cattgtgacg tctgtttttt tgtataaaat 3097621 cactgtgaaa acgggacagt ttgatatcat tcgcagctct gttctctcga ttactgatga 3097681 ccgacggctt caagctctct tgatcgcttt ttcattcggg gcttttttag aaggggcagc 3097741 aggcttcgga gcgccggtcg ccatttctgc cgcgctgctg gtcggtctcg gctttaatcc 3097801 tctttatgct gcggggatct gtttgatcgc caatacggcg ccggttgcct ttggggcaat 3097861 tgggattcca attacagccg tagaagggcc gacagggatt ccggcgatgg agatttcgca 3097921 aatggttggg cggcagctgc cgtttttatc cgtatttatt cctctttatt taatcatcat 3097981 catgagcggg ttcaggaaag ccttggagat ctggccggcg attctcgtat ccggtgtttc 3098041 ctttgctgtt gttcaatatc tcagttccaa ttttttaggg cctgagctgc ccgatgtttt 3098101 gtcagctctt gtttcaatgg ctgcgcttgc tgtgtttttg aaatggtgga agccgaaaac 3098161 aacattccgg tttgccggtg aacaagagtc ggccgcctca attgaaacgg cgcgcacaaa 3098221 tccggcggcg cctgcataca gaggcggaca gatttttaag gcttggtcgc catttctgct 3098281 gctgacggcg atgatttccg tatggggcat tccatctgtc aaatccgcgc tgaccgggca 3098341 ttatgaaggc tctgcggtgt tcttgaagtg gctgaatgct gttggagaaa aactgacttt 3098401 ttcccccggt gtgccttttt tgaacaatca gattgtcaat gctgacggta cgccgattga 3098461 agcggtttac aagttggagg tgcttggttc ggccggcacc gcgatattga ttgccgcagt 3098521 gctgtcaaaa ttcatcacgg cgatttcgtg gaaagactgg ggaaccgttt ttaaagaaac 3098581 agtccaggaa ttgaagcttc cgattttgac cattgcttct gtcgttggtt ttgcctatgt 3098641 caccaactcc tcgggaatga gcacgacact cgggatgaca ctcgcgctga caggttcgat 3098701 gtttaccttc ttttcgcccg ttctcggctg gctcggcgtc ttcattaccg gctcggatac 3098761 ttctgccaac ctgctgttcg gcaacctgca gaaagtcacc gcattatcag tcggcatgga 3098821 ccccgttctg tctgtggccg ccaactcttc aggcggtgtc acaggaaaaa tgatttcacc 3098881 gcagtcgata gcggtggcgt gcgccgcggt aggactcgcc ggaaaggagt cagatctttt 3098941 ccgctttacc attaaacaca gtctgttttt gctgctgctc gtctgtatca tcaccttttt 3099001 gcagcatcac gtattcagct ggatgattcc ttaaaaaaat cctcccgtct agggaggatt 3099061 ttatttatat cgctttctcg ctgccgatga cggaatattc atttgatcgc gatattttgc 3099121 cacggtgcgt ctcgagattt ggatgccgtg ttgttcatac agcaaatcga caagcttttg 3099181 gtctgaaagc ggttttgttt tgtcctcttg attgatcagg ttttccagat gcgttttgac 3099241 tgcataattc gacgcatctc catcacctga agcctcggct tttgctgaga aaaagagttt 3099301 catctcaaac agcccgtaag gcgtttgtat tgttttccct ttaatggccc ggctcacagt 3099361 tgattcatga aggcttagac agtctgccac ctctctgaga gtcagcggct tcattgcgct 3099421 tcgccctttc agaaagaaat ccttttggcg tgtgatcagt tcattgataa ttctcgtgat 3099481 tgtctgtttt cgctgccgca gcgcgcggct cagccagcgc cactcctgat atttcgcaga 3099541 taaataggag acagtatcct gacaggagcc ggatgataaa agcgttctgt actgcggatg 3099601 cagatcgatc tcgggaaacg agcgggtatt cagttccgct gcgatgtgcc cattttttac 3099661 ggtgataaaa atgtcaggct caatatacac atcttgctct ggccgggcaa acagaaggcc 3099721 aggtctagga tgaagagccg cgatatcatc tgagatatct tgaatggtat gaagcggaat 3099781 tcccgtctct actgaaagcg ttttccattt tttttgcgca aaagcatcaa aatgagctga 3099841 aaccagcatt tccgcttgtt catttctgtt cggcagccgc tgtaattgaa gaaggatgca 3099901 ttcctgcaaa gatctcgcgc cgattccagc cggttctaac gactggagtt ttgccaaaac 3099961 agcctccgct tccttggccg atacagataa tcgccgtgct gcctcctcta tatcttcttc 3100021 caagtacccg tttgaatcaa gcgaatgaat cagataatta aaaatctttt tttcagtgtt 3100081 tgtcagattc atatcgagtg actgctgttt taacgcatcc tgcaatgttt tttgcggatt 3100141 acttaattga aggcccgctt cctgtgcatt catcctgttt ttgtttgttt tatggtaaga 3100201 tagtggcggt gtgtctgttt cctttcgttc aataagaggg ttttccagtg agagctcatc 3100261 aatgtactcg gcgagttctg ccgaatgata gccaagcagc gtgatggcct gcctgagctc 3100321 ctgtgtcagt tgaggcttta atacttgtac ttgctgaagt ttcatatcca tcttgctcac 3100381 tcccctttct tcattgtaca tgattgagat cacaccgtat acatttatga aaaaggagct 3100441 gccaaagaaa tgtctgaact tttttccgtc ccttatttta ttgagaattt aaaacagcat 3100501 attgaaatga atcagtctga ggataaaatc cacgcgatga acagctacta ccgttccgtc 3100561 gtctcaacac tagtgcagga ccagctgacg aaaaacgcag ttgtcctgaa acggattcag 3100621 catttagatg aagcatacaa caaagtcaaa cgtggagaat caaaataaac cttccgctca 3100681 catgtgagca ggaaggtttt ccttctttga ggcgtgctgg atgagacggg tgcttggcac 3100741 gccttccatc caggtatgaa agtaattggc gtttttcccg taggaattat caatgaccgt 3100801 gttttctttt tgaagaagag aagacaggat gtggccgtgc agccttgatg tttccaccga 3100861 ttcgtaacgg ctgaaaaacc gaatcgcttt ttggacgata taatccgagt atttttccca 3100921 tatatacgca atgggcaaag ggttgcctgc ttttttattc aagacgttca gcgtttggag 3100981 aaaagcaatc gtccggcggt ctgaagctga cagcaccgtg cgccagtcgt agctttccgc 3101041 ttctgcgtgt tcctgaagcg cctggtttgc ttcatgatct gttcggataa atctcagctt 3101101 ttgattggac ggctgctgcg tgggaatgac gggaaacagc tgatgagcca tatcaggcag 3101161 aagctgaatg tgatttgttg taaaataggc ctgtgccgta gcataggagg ctttttccct 3101221 tgtcatgatg tgaaggttcg catgcttaga aaatatctct gccgtccgct tgaggttgtc 3101281 tttgttttga aaataaatcg attgcggcag gatcacaatt ttgtggttcg gataggtttg 3101341 gacgattttc tctctaaagc cttgataata cggatacaga tccccgaagt ttccgcctcc 3101401 ctggcagacg atgatgagat tcggatcaag ctttcgcccg attgggaaat tgtctggatt 3101461 ccagcgtttt ctgacccgaa tcccgtgttc tttaaagaag gcttctgttc ctttcataat 3101521 aaataaatcc cctacattcc catatagagg atagtcagca tatataatct ctgattgttt 3101581 cggaatgacg tcgagcagcc cggacagttt ctgtttcagg ctgatcatcg aatgcttgct 3101641 gtccatttct tcacctcgac agtatggaat aagtgcagta gcacttcaat gacccggcct 3101701 tgctcatctt ctgtcatatt ggaccccgat gggagacaga ttcctcgctt gaacaaatct 3101761 tcgcatacgc ttcctgtatc ttcatgagaa taaaataaag ccggatcgaa cagcggctgg 3101821 gtatggagcg gcttccacag cggacgggct tcaatgtttt cttcagcaag acgttgaact 3101881 atgtcatatg ggctgagccc gttatcaagt gtgagcgtgg tgagccagcg attggatacg 3101941 cctgctgcgt actctggcat aaagcggacg ccgtctaagt gaccgagcgc atttttgtat 3102001 ctcgtgaaaa tggtccttct tttctccact cgctcatcca gcacctcaag ctgggcaatg 3102061 ccgacgccgg ctaagatatt gctcagcctg taattatgtc caatttcact gtgctgataa 3102121 tgaacagccg gctctcgtgc ctgcgaagcg agaaatcttg ctttttcaat tgcggcttca 3102181 tcatttgaaa cgagcatccc tccccctgat gtggtgatga ttttgttccc gttaaatgaa 3102241 aaaatgccga agcgcccgaa tgttccgctt tgcttccctt tatagactgt gccgagagat 3102301 tcggctgcgt cctcaatgac aggaactccg tatgcatcac acaggcttac gatttcatcc 3102361 attttcgcgc tctgcccata tagattgacg gcaattaccg cttttggcag tgttccgttt 3102421 cttttcgctt cctccaatgc tctttcaagg gctgtcggcg acatattcca cgtatcaggc 3102481 tcagaatcaa taaagacggg caccgctttt tcatatagaa tcggattggc ggttgctaca 3102541 aatgtgaagg actggcaaaa cacgctgtca ccttctttta cctcaagcaa acgcagcgcg 3102601 agatgaatcg ccgccgttcc tgagccgacc gcagctgctg cttttacacc gactcgttct 3102661 gccagctgtt cttcaaatga attcacgagc ggcccaagcg gcgcaatcca gtttgagcga 3102721 aaggcttctg aaatatagtg ctgctccctg ccgctcatat gagggggaga taagtagatt 3102781 tttttatgca tagaatcatc ctttgtttga tgtttgaatg gaagaaatga tgcgtgccgg 3102841 agcaccggcc gccgttaccc tgtccggtat ggaacggatc accgcggagc cggctccgac 3102901 aatgctccaa gccccgatta tgatctgcgg tatgacggat gcaccggttc cgacgtgagc 3102961 gccttcctga acggaaaccg ctcctgacag cgtggcacgc ggggacagat gaacgtaatc 3103021 gctgatttga ttgtcgtgct ctgccactgc acccgtattg atgatgcagt gggcgccgat 3103081 gcgcgcatcc gcctgaatga tcgcgcccgc cataatcact gtcccttccc caatgacagc 3103141 cgacttgctg acgatggctg acgggtgaat caatgtaata aaatcatctt tccccagtcc 3103201 cagtcgctcc gccagctgtt ttctgacact gttattccca acagcaatca gaaacagcac 3103261 atcaggaatg agcctgcgca gttcagtaac ggctttcggc ggtcctgtgt accattcttt 3103321 tccgccttcg aacgttttga atttatcatc cagcaccgcg gctaagcgcg tatctgagcg 3103381 ggcgtttatc agctctctga tcacctttcc gtgaccgccg tcacccacaa tggccacatt 3103441 tttcatgagg acacatctcc gcttccggta aaccgttccg cggtcacatg attggtttgc 3103501 tgaatccctt ctgaaacaag gacctttcgc accgtcaaac ataaaatttt caaatcgaga 3103561 aaaaatgacc agttgtcaac gtaccaaaca tctaattcaa atttcttttc ccaggaaatc 3103621 gcgtttctgc cattgatttg cgcccagcct gtgatacccg gcttcacctc atggcgccgt 3103681 gcctgttttt ctgtataaag aggcagatag tccatcaaaa gcggccgcgg cccgacaagg 3103741 ctcagatcgc ccttcaggac attcaggagc tgcggaagct catcaatgct cagctttctg 3103801 atcagcctgc ccgttttcgt cagccggact tcatcaggca gcagatttcc tttactgtcc 3103861 cgttcatccg tcattgtccg gaacttatat agggtgaacg gtttgccgtg caggcccggc 3103921 cttacttgct taaagaagac aggtgatcct attttcagcc tgacaacggc gatggtgaac 3103981 agaatgatca cacttgtaca gcacaacaaa aaaatggcgg ccgtcagatc aaaaagtcgt 3104041 ttcaggatca aagattcaca gctcctttcg tttttcgaaa ccgttttaat accagctgtc 3104101 tttcctcttt tgtacaaacg agcataaaag cgaaaacagc gtagcaaaag ctgactgtca 3104161 ctcccgtcgc tatcaatgac ggccagctgt caatcttcac aatgaactga attgccttac 3104221 agaccgtcca ggcaaataca gcggctgaaa gaggcccgat tatgccttta aggaacacgt 3104281 gctttttgta gcctgtaatg cgggatacgt aaagcggcgt aaagatggca ttttttaaaa 3104341 taagagaaat ggcccctgcc aatgttatgc cgtacagacc gagatgagcc ggcccgctca 3104401 gcgtgaccgc cagcaccaca ttcaccgcac ctaacagcag ggtaacaatc gccggtgttt 3104461 tttgttgatt aaaagcggtc catatataaa acagcggcat aaaggcgagg ctgacaacca 3104521 agtatccggc atgaataaat aaaagcggtg ctatcgttga aaaggacggt ccgagccaga 3104581 ttgtcagaaa aggtcccgcc aatccgccca ataaggcagc aggaagtgca agcaaaagac 3104641 cattgagcct tactgcctta ttggcgtaat tcatcaatcc ttccatatcg ccttttgaat 3104701 aatatgaagt catgatgggc gcaaacaggg atgcgaccgt tccggccaag ctgcgcaaaa 3104761 gcagcggaaa ctggataatc gccgcgtatt tcccggatgc agacgccccc agcatcaaat 3104821 tggcggttaa cagatcaatc tgcaaaaaaa gcaggacgcc gatttgattg acggagctcc 3104881 atgcgcccgc ttgaaacagc tccttgcttg tacggaatga aagatccttc atacgaaacg 3104941 aaaaccacgg aatcagcttt ttgaagaaat agaaagacag cacagacgca ataacagcac 3105001 cagctaaagc tgcaagctgg atctgccaga ttttcggcgc aaagcatgca aacaggagca 3105061 gcacagacag cacccgtata agcatttgca ccgcctgaat ggaactggtg atataaaggc 3105121 ggttggcata aaatggtgca gcgccgaagc ccgccatcag aaacgttaaa ataaacagca 3105181 cactgccgat taaaatcgac aaacgcacat ctgccaaaag cgcttgcggc acattcatga 3105241 cgcggtcaat aaaaaaagcc gaacccgcaa gcggcagcaa gagcagcaag gaaatcaaaa 3105301 cagaggcggc taaataattg ctgatatacg catttgcttt ctcccgctct cccctgtggg 3105361 cagcaacaga aaagaaccga acgacaaccg agctgagcgc cacggtaata accgaaaagt 3105421 aattaatcac attttgtgtc aagtgaacaa agccaaacgc ttcgacaccg agcgttttga 3105481 caataaaagg cgtcatccaa accgatagga aaacagacaa gagaaaagcc gtgagattcg 3105541 cgctgaaatt tatcgtgaat ttcatgcctg cttcgcactg cctttcattg tcccccgctg 3105601 ctcgaaaaac agcttgatga gaaaagtgag ccgccattta cacagtgcta ataccaaacg 3105661 ctctcctctt aataatttct catgctgaaa cggtgtatgt ctgacagcct gccgcaccat 3105721 gtcataggat aaaatctgtc tgatcttctt tttgatgtct ttcggcgaat tcggagaagc 3105781 acaggcattt gccaaaagca tcggaagctg gtgcctgcaa atgtacacat tcaaatcttc 3105841 tttacatgcg cctgctaagc cgtagtgatt gtagaatgcg attttagcct gatattgttt 3105901 ttgaagatgt tcatccatcg ccggcttata agggatttct gtcaggctgt tcgggttttc 3105961 acgataaatg tacaatcctt catcaagcat tttcacccgc tccgcttcgc gaaaagcgga 3106021 caaattaaag ggagagtctt cagcaaaacg gatgtcttca tcaaacagca gattcgccct 3106081 ttcaaaaagc tcacgacggt aaagataacg ccatacatac cagataaatc tcgtttcgtg 3106141 agcatgttta agctgttcag tcatttctgg tttcgtcagc acgcggtttg cctcaagctg 3106201 cggcggcaca tatgtccgcc tgtccgatga ctgcttgtaa aaaccgcatc cgacgatgtc 3106261 aagctgattt tgctccgctt cttcagtcag cctctggaac atggcggatg atacataatc 3106321 gtctccgtct acaaagccga tgtaagtgcc ccgcgcggcc tttattcccg tatttcgcgc 3106381 tgaactaagc ccgccgtttg cctgatgaat gacccggatt ctcgcatccc gttttgcata 3106441 gtcctctgca atttcgcctg aacgatccgg tgttccgtca ttcacgagga tgatttcaat 3106501 atcagaaagc gtttgacgaa gcaaagaatc aatgcactct tctataaatg gttcaacatt 3106561 atacatcggg acaataatgc tgacgagcgg gatcattgcg cttcaccgct gattttgtca 3106621 cgcagacctt taaaatacac atctctcgga aagcctgcac gggatgtttc ttttgttaaa 3106681 agctcattga ctgcggctgt tacgcgctct ggctccggat gttctatcag cttcatgaac 3106741 gggatgtctt taagccattg atagccctcc atcaccttat ggtcaaagga gcgaatgaca 3106801 acacacggcg ttcctgtcag cgcgcaaaaa atcatgccat gaagcctgtc agtgacgacg 3106861 gcttctgcgc tttgcagctt agaccacagt gcttcaagtt catgttcgcg tgtatcgcgg 3106921 ctgacccggc ggccgatcgt tgtcgtaaag gatttgatct cgccgaattc ctcacatagc 3106981 gcagccttga cccggttcct ctgctcctcc tgaagcacgc tttcctgatc ctcgcgcaaa 3107041 cacatataaa ccccttcgcg ttctgcggga gccttgcttc tgtctaaata cagcaccatg 3107101 tccggctgct tcaaaattgt tttttcttga aaatgctgtt tcataaattg atacgttgtt 3107161 tcatcccgcg ccatcagcaa taggccgggg tgcgcattat aaattttctg tgcccgtttc 3107221 agctctttgc gccctttttt cgtgtcagaa aaatgagccg ttgccggaag ctggacaacc 3107281 cgatagtcat ggaatgtttt aatgatgaag cggcgcgtcc actcctcata acggtataaa 3107341 tcccccatgt ttccgccgcc gatgataaag accatatcct ccggatggcg cgagcggatc 3107401 aggctttttg ctgatttgta aatgtccttc atatcgacct cgacgatgtc aaagtccggg 3107461 tattcttgct caagaaatgc cttgctggca taagcaattg cgtgatctcc caaattgtca 3107521 tgggacggca gcagggtcag tatgattttt ttctgatgtg ctgcggcctt taccggttga 3107581 tctgccgctc ccagccaata ttgggacggg tatttgacct ttagcagcag ccattctgca 3107641 aaattgattt tcaacgattg taacgacatg tcctcaccct ctgtttctca ttttgtactc 3107701 gatcacccgc tgatacacag ccgatgccat agcgacgaac ggaatcattc tgtatttcgc 3107761 catcagaagc aggcatgacc gttttgcgtc aaaaggagca gtacccgttt ttgaaagact 3107821 ttcttgaaac accgggtccg cgcatatcac gccaacattt ctaagctttt caaacagccg 3107881 gcggctgccg ctcgttttcc attcattcag catacagatg ctgctgtgaa gaacgataaa 3107941 ggtatcaagc tccttgcgat actcctccag tttgttgttc tcctgtaaaa acgccgcatt 3108001 cgtctcatac agcgcaagtc ctgattcaaa caattttttc tgatagcgct gcacaatgga 3108061 ggaaaggtga attcgataat gatagagcgg cgtttttacg taggatactg agcgggcgaa 3108121 aaaatgagcc ctgaagctga aaaactgatc ctcgacatgc tccagctcgc ctcggagcgg 3108181 aaacgacagc cgatgggctt caatcatgct tcttctgtac agtttgttcc atgaaaaccc 3108241 tctgaccttc ccttcgaata acgccttgat atagtgctcc ttcggctgat cctgataggt 3108301 ttgggcaatg tcagagtcca tggttttgcc agtgtcctca aactctgcgg cgtaattgca 3108361 aatgaccaga tcagtttcat cgcctgctgt ccggagcatc tgctcgcaat aatcaggctc 3108421 aatccaatcg tctgaatcga taaacgcgat aaattcgccg cgtgcagctt caatgccttt 3108481 attccgaacc gcaccgagtc cctggttttc ctgatgaatc accttgaacc tgttgtccat 3108541 tttggcgtat tcttctgcga tatccgggct ggcgtcagct gaaccgtcat tgacaatgat 3108601 gatttcaata ttgtccattg tctggttccg cagtgattcg agacacgttc tgatatatgt 3108661 ttctgtgtta taaacagcga ctaacagact aaccgcaggt gtttccataa tgaccggctc 3108721 ctcgtgcata aattaccggg aaaaaatcgt tctgtaaggc agaaccgatg aatcgaccgg 3108781 cataagcaaa taactgtaaa gaaaataaca aacaacgata gcgatataga taagagcgtt 3108841 cgatttttca tcaaatatcc tgacgaaata agggactagg atcatttgat acagaccgaa 3108901 ataaatattg aatctggcaa aaatcacgtc ctttgtggcc aaaaggccga acaaaaaacc 3108961 tagcaggcac aaattgacga caatatcaat ttgcggccac agactccgca gtcgttcttt 3109021 atagcaaaat gcaaggaaca gcggcagaac caaaacagcg attttgatca cattcattcc 3109081 atttgtgttc gtcatgagcc atttttcata atggctgtat gagctgtttt caagtacaac 3109141 gacaaacaca gaaataaatt tttgatataa aaatgtcatg ccgagaaata aagcggatag 3109201 gccgaatatc gccggtgacc aggcttttct tctgacaata aagtacactg gaatcataat 3109261 cagcgccgac gaatgaaaga gcgagctgac cagcacaatc aggaaatatc gcttccagtt 3109321 cccgctaatg atataacgga tcgcccaaaa caaaacagct gccaccatgt attgcctgat 3109381 gccgttaaaa gatgcgtaat aatgaaaggt tcccaaaaat aaaaagacac tcagctcaaa 3109441 cggcctgcca tagtcggcga gtgtcttcat aataaagctg taggtcacga ccgccaccgt 3109501 aaaatacatg atttgaggat cttccgtgat gaaattcatc agccaaagga gtgcggtaaa 3109561 ccccggatct gtcgctgttt tcgctgtgcc gaaaccgaat atctgccaca cattttgata 3109621 atcgcccgcc aattcgtaca acagcgtgta cgtctgaaaa tccgtgccga ctcgatagcg 3109681 gagacctgac acgagcacaa gtgaagcgag cggaatccag atcaaaagct tattcggccg 3109741 ataccccgtg gcaagcgaat catcacggcc gccgcacatt ttagcgaacc aagaccaaat 3109801 aaatacaatc cccatattga cggcatatac aatcatcggt tatggtcctt ttccgtgctg 3109861 atgttgtata cattcagcag cgctcctaca ttttgctgtg catcgtagcc aagttgagcg 3109921 agtgtttctt tgatgaactc acgcttcggc ctgcctgcgg cggccgccct tgcaatggtt 3109981 tcagcccaga cgctgatcgg ctcagaaaga cttaatcttg tgacaagccc gagaccggcg 3110041 tcgacttttt ctgtaatgct gtctgaaatg atgcatggaa gccccgacgc ctgcgcttcc 3110101 acaagcacaa ccggcaagcc ttcgtacaga gacggcatga caaatacatc gaatgttcgc 3110161 atcagttcat ggatccgttc ttccgtgcct aaaaagagga cgtctgatag caaattctgc 3110221 tgccgcgcct cctcctctat ctccccgcac aacggcccgt ctcccgccag aacgagctga 3110281 aagcgaatgc ctctttcctt gagatgtgcg gcaagcttca acaggaacgc gtggtttttc 3110341 acttcatgaa accgggccac atggccaatg atgagccggt cggctgcaat gccgcgtgct 3110401 gctttttctt catcagccgc ctgcccattt ggggcgaaca actcaaggtc aatcccgtta 3110461 ggaagaaggt gaacacgctc ccgctccata ttggactgtc caaataaaaa cctgcccgca 3110521 tcctctccgc aggcacacag cgctgtcgca tttgccaaaa tgagccgcct gaacacgagc 3110581 agctgcaatc gatccttcca gttgaagccg gtcttccaag acgtattgtg ggagtggcat 3110641 accctgaccg gcactccggc gagccttgcc gcaagggcga taaaacccgt ttggaaatcc 3110701 gtgtgcgcat gaacggcgct gaacggccca ttttctttta tcgcgtttct cacattcctc 3110761 acaaatgtaa ggggattgct ttgcccaatg ctcgggacat aaaaaagccg cccgcctaaa 3110821 gataaaatct cttcatcata agcgcacgga tcatttcgat acgttaaaaa atcaaattgc 3110881 actttgcttt tgtccatctt ccgatataaa ttcattacca tggtttccgc gccgcccctg 3110941 ttcatgccgc tgagaacatg gagcacgcgc ttttggctgc tattcatgct tgacaagccc 3111001 ttccttttgg ttcatcactc tttttttatg gtagcgattc atcacagctg caggcataaa 3111061 ggcgcgaatt aacggttttg cgatatatat gtaatcagat aaaggaagct tcaagcgtct 3111121 gcacgcctga tagacaagaa tggcattgtc gattgaatac gtaaatgacc gccgtttgaa 3111181 tgcatcgctg tcttccctca ctttatacaa ggcttcctga agattatagc ccctgaagcc 3111241 ctcttcaaaa aagcgaagcc acaaatcaat atcttccatt cgtctcgtcc gccgcaccga 3111301 ccggtagcct ttcagcgtgc ggtaggcact cgctctcatc ataatcgtgc cgtggcaaaa 3111361 tggagtccct tttgccatga tgcccggctc cggaacagaa ggcagaatgc gggcgcctct 3111421 tacgccaaat tcatcaaaca caagcatgcc ggtgccaacc acctgatagt gtcggtgctt 3111481 ttctaaaaac gcgacctgct tttccagacg gcgcggaaac gaaaggtcat ctccgtcctg 3111541 acgtgcgata taatcgcctg tcgcatgcga aagacaatga tttaatgatg cggcaagccg 3111601 cttatttgtt ttgttttgaa tcagtttgat gcggtcgctg taatgagcgg catactgctt 3111661 cgcgatacgg agcgtgccgt ctgttgacgc atcatcgcac aaaatcagct cccaattttt 3111721 ataggattgg ctgagtatgg attctatgct ttctgccaaa gtgcgttcgc aattataaat 3111781 gcccataatg acagaaactt tcggtcctga gttcatacgc ttttctcctt tgtatccata 3111841 tccatgtacg cggaataaat atctgccatt tcttccaccg ttcgcgcctc cgagaagcgc 3111901 aaggctgttt ttcggccttc ctgtcccagc tttcggcaga gctccggctt atggtaaagc 3111961 tgttcaatcc ggcgggcaaa agcagcactg tcaccgattt tgatcagaaa accgttttct 3112021 ccgtcgcgga tgatttcccg atgcccgcga ttatctgtgg cgatcgccgg ttgttctgcc 3112081 gccattccct caagcacatt cataccgagg ccttctctaa tgctggatgc gacagataca 3112141 tccgcaagct gaatcaactc atgtatgtcg ctgcaaaagc cgtaaaaaca gacatgggcg 3112201 gaggcaccaa gcttttcagc taacgtttga tacgtatgtt ccattgcccc ttccccggca 3112261 aacacaaggc ggagtgaggg aattttttct tttagcaagg ctgcggcttc aattaactgc 3112321 ttctggtttt tgttcagatt gagctcagcc ggataaacca atataaaatc atcttcacgg 3112381 aacccgtgct tttctctgag tctttgctgc tctatcggac tgacaggccg gaaacgctcg 3112441 gtattgacgc caatgccgtg aattttctgc gtccttccgc ccggcctttg aagtcctttc 3112501 gcccgtatgt aatcctcttc attaatcgta atcaggcagt ctgtatatgc tgaaagccat 3112561 ttctcaaccg gatagtaaag aagccaattt ttcatcggtg cccctttgca gaagtgaaat 3112621 ccgtgcgctg tgtacagcac ctttgttccg tgccgccgtg cctgcctcgc cgccagtctg 3112681 gcgagaacgc cgccgaccgg tgtatggcaa tggacaatgt cgtattcata agtgtcaatc 3112741 actttcttca gctgcctata aacggccagg ttctgagggt caaaaggtga cctgcgaatc 3112801 gggatggaga atttctcatc cacatacggc agcttggttt gtccgttcgc ggcgacatga 3112861 acctcccagc ccatttgctt gaaccattta aaataaggga ggtgaaaggc cttaaaatga 3112921 taatcaacag tcgcgcaaaa caatatcttt ttcgtcattt tcactccccc taatgaacgc 3112981 tggcagccgt catttcttct gatgtattga ttgccgcaaa cagcctcgct ctcaggtcgg 3113041 cttccggcag ctcatgaaaa tcctcgataa agcgcatcag caccggccaa tcgccgtcca 3113101 ccgctttacc gatgtgaatt tttggaaaga tttgttcagc atggacttca tttttgttca 3113161 gcaattcttc atacattttt tcgcccggac gaatgcctgt gaattcgatt ggaacctgct 3113221 cagtcgtgta gccggacaaa tgaatgaggt ttttggcaag atccacaatc tttacgggct 3113281 ctcccatatc gagaacgaaa atttgacgcc ctttcgccag tgccccagcc tgaatcacaa 3113341 gccttgatgc ctcgggaatc gtcatgaaat agcgggtcat tgccggatgt gttactgtca 3113401 ccgggccgcc tttttcaatc tgttttttga aaattggaat gacgctgccg cggctcccga 3113461 gtacattgcc gaagcgaaca gcaacaaatt tggttctgct gactttccca agattcataa 3113521 taatcatctc tgcgaatcgt tttgtcgccc ccattacgtt ggctgggttc accgctttgt 3113581 ccgatgaaat cagcacgaat gtctcagttc ccgacatatc ggctgcttcc gcgacatttt 3113641 ttgttccgat aatattgttt ttgaccgcct cttctggatt gtgttccatt aaaggcacat 3113701 gcttatgggc agctgcatga tagacaacat gcggctcgta ttttttcatc aaggtaaaca 3113761 ttttatcgcg gtcctgcaca tcagcgattt ccgtatggaa cacaatgtgt ttgccgaatc 3113821 gtccgttcag ctctgtataa atcgaatgaa tgctgttttc cccatggccg agcagaatga 3113881 tttccttagg ctgaaacgcg ctgatctgac ggcagatttc cgagccgatt gatccgcccg 3113941 ctcccgtgac gagaactgtt tttcctttga tgcggttcga aatttcgcta gtgtcgaggg 3114001 ttaccggctt tctgccgagc aagtcctcag cttttacatc tctgatttgt ccggcagttc 3114061 gtgtgccaag cagcatttca tcaaaatgag gcataatttt aatgcttact ccggttcgca 3114121 cacattcttt atataacacc tgaagctcat gggtgcggag tgaaggaatg gcaataataa 3114181 tataattaat tttgagcttt tgcaccgcag gcatgatact ttcttttccg ccgattacgg 3114241 gcagccccat aatttctaat ttatgcttcg tttggtcgtc atcaataaaa gcgacaggta 3114301 tgatatcagg ttcatctttc gaaagcagct gcctgaccat cagagtccca cctgagcccg 3114361 ccccgataat cagcgcgcgg gacgaggcgc agcgtttttt cctgatgctt tcgtttaata 3114421 ctctggataa aatacgggtc cctccaatag acaaaagctg aagcacccag cacgcggtta 3114481 acagacggaa gaacatcgtg tgatacacag catactgaat gacgccggtc acagcggctg 3114541 aaagcgtaat gcccttaagc aggacaatca gctcgccaag cccggtgtat gtccacacct 3114601 gtttatactg attgaacagg aaagcacaca catgatagct gaggagcaag ctgacagcgg 3114661 taagcagtaa tgctccggag tcataaaatt gataggaatc ttttaaaaat tgatatcctg 3114721 caataactga atttaaaacg aggtaagtat ccagcgcaat aatcattgac agtcttctcc 3114781 ggtaactcaa ccttttcccc cctaattctt ttatcggttt agctgcggcg gttttcgtct 3114841 ctccaaaaaa tcggcagcag ctaaaccgac aatacgtcct atgtatatat gagataagtg 3114901 ggcatttaac ccatcctcac gccccgccag cgacgaccag catctaaggc agcaacttca 3114961 gctgcccaca gcagagccga gtgcctccat tgatacaggt caggagacat cacctttaca 3115021 aaaactagta ggaatagtgt tccgattttt tcattttctt tttgtttaaa agagcgccta 3115081 acagcttcgc attggattgt tccagtgcat cttttgcttt cagaacggta tcggtttttg 3115141 tttttccgct taaaacgacg agcacgctgc cgtctgtctg atttgctaga atctgagcat 3115201 ctgcaacagc caaaagagga ggggaatcaa agatgacgag gctgaattgt tcatagatct 3115261 cagatattaa atctcccatt gcttttgaag acaacagttc tgccgggttt ggcggggtcg 3115321 gcccgcttgt cagtacatat aagttatcga tcggcgtctt ttgcaccgtc tcactgagtg 3115381 aagcattgcc gaccagcaca tttgtcagcc cggttacatt atcaacctga aacgtctgat 3115441 tgatggtcgg ctttcttaaa tcggcatcca ccagcagtac tttcttttcc tgctgctgcg 3115501 caaagacagc cgcaagattc gctgcactga acgatttacc ttcaccaggc acagaggagg 3115561 tgacgaggat agatcgcaag ttggtctgga cagatgagaa ctcaatgttt gtccgaatgg 3115621 tgcgatattg ttccgcaaca actgatttat tgtgtaaaac agatatttga gccaaacctc 3115681 gccttgcttt cttttttcta aagatcactc gcttcactcc ccgaaatgtt ttatcccgcg 3115741 attccgccct ttgtggacat caggaacgga gcctaagcat ggcaatccgg ttctctcgct 3115801 gagctgccgt gcgcttttgc atgtatcatc gagaaaatgc agaaaaaatg ccagtgtaat 3115861 gccgcccatg acagcagcgc caaaagccat gaccatattt cgcagcctgg ccggcttgat 3115921 catcgggctt tccgaagcct tcgcctctga taatatatgt acgccttgta cattcattct 3115981 ttcatctact tctttttcaa acttgttcac taacgtgttc gcaatctcag ctgctttcgc 3116041 cggatcgtga tcctgaacgg caacgttgat tatttctgat tcattttcac tgctggtaac 3116101 cacttttcct ttcagcgagg aagccgattc agataggtgc aattccgcct taacttcttc 3116161 catcaaggca gtgcttttca taatcgattg gaacgtgctg ctatactgaa gatttcgctg 3116221 gatgtcactg agattcgagt tttcttcacc gtctgattca tgaaccagca cctgtgtcga 3116281 cgcctggtag gtcggtgaaa tgaccttaaa ttgcacaaaa cccataataa gggtgacgcc 3116341 gattgtgatg agcagaatca gcacgaatct gtgtctgaca atcgcatata attctttgaa 3116401 actcatattc tcattcatgt attcatagcc ttcagccttc ccgcggctgg cttcccgcgc 3116461 ccctttctgt taatgattgg attataaaag aaaacgttat tatttaaaaa ttgcaaaata 3116521 agccaataag ttctctttag agaacaaaat catgattttc ctctaattta ctgcacttcc 3116581 cttattattt taaattttat aaagaacgaa aaattcctta taatgaacga aataacgaca 3116641 ggaatagagg agaatttcat attatgattg gaagaattat ccgtttgtac cgtaaaagaa 3116701 aaggctattc tattaatcag ctggctgttg agtcaggcgt atccaaatcc tatttaagca 3116761 agattgaaag aggcgttcac acgaatccgt ccgttcaatt tttaaaaaaa gtttctgcca 3116821 cactggaagt tgaattaaca gaattatttg acgcagaaac aatgatgtat gaaaaaatca 3116881 gcggcggtga agaagaatgg cgcgtacatt tagtgcaagc cgtacaagcc gggatggaaa 3116941 aggaagaatt gttcactttt acgaacagac tcaagaaaga acagcctgaa actgcctctt 3117001 accgcaaccg caaactgacg gaatccaata tagaagaatg gaaagcgctg atggcggagg 3117061 caagagaaat cggcttgtct gtccatgaag tcaaatcctt tttaaaaaca aagggaagat 3117121 gatgatcggt taaagggcta acgttcgcat ctatagggga aatctgttta taatggggga 3117181 aaaagggaga gaacacaatg actcatcaaa tagtaacgac tcaatacggc aaagtaaaag 3117241 gcacaacgga aaacggcgta cataagtgga aaggcatccc ctatgccaag ccgcctgtcg 3117301 gacaatggcg ttttaaagca cctgagccgc ctgaagtgtg ggaagatgtg cttgatgcca 3117361 cagcgtacgg ctctatttgc ccgcagccgt ctgatttgct gtcactttcg tatactgagc 3117421 tgccccgcca gtccgaggat tgcttgtatg tcaatgtatt tgcgcctgac accccaagta 3117481 aaaatcttcc tgtcatggtg tggattcacg gaggcgcttt ttatctagga gcgggcagtg 3117541 agccattgta tgacggatca aaacttgcgg cacagggaga agtcattgtc gttacattga 3117601 actatcggct ggggccgttt ggctttttgc acttgtcttc atttaatgag gcgtattctg 3117661 ataaccttgg gcttttagac caagccgccg cgctgaaatg ggtgcgagag aatatttcag 3117721 cgtttggcgg tgatcccgat aacgtaacag tatttggaga atccgccggc gggatgagca 3117781 ttgccgcgct gcttgctatg cctgcggcaa aaggcctgtt ccagaaagca atcatggaaa 3117841 gcggcgcttc tcgaacgatg acgaaagaac aagcggcgag cacctcggca gcctttttac 3117901 aggtccttgg gattaacgag ggccaactgg ataaattgca tacggtttct gcggaagatt 3117961 tgctaaaagc ggctgatcag cttcggattg cagaaaaaga aaatatcttt cagctgttct 3118021 tccagcccgc ccttgatccg aaaacgctgc ctgaagaacc agaaaaagcg atcgcagaag 3118081 gggctgcttc cggtattccg ctattaattg gaacaacccg tgatgaagga tatttatttt 3118141 tcaccccgga ttcagacgtt cattctcagg aaacgcttga tgcagcgctc gagtatttac 3118201 tagggaagcc gctggcagag aaagttgccg atttgtatcc gcgttctctg gaaagccaaa 3118261 ttcatatgat gactgattta ttattttggc gccctgccgt cgcctatgca tccgcacagt 3118321 ctcattacgc ccctgtctgg atgtacaggt tcgattggca cccgaagaag ccgccgtaca 3118381 ataaagcgtt tcacgcatta gagcttcctt ttgtctttgg aaatctggac ggattggaac 3118441 gaatggcaaa agcggagatt acggatgagg tgaaacagct ttctcacacg atacaatcag 3118501 cgtggatcac gttcgccaaa acaggaaacc caagcaccga agctgtgaat tggcctgcgt 3118561 atcatgaaga aacgagagag acgctgattt tagactcaga gattacgatc gaaaacgatc 3118621 ccgaatctga aaaaaggcag aagctattcc cttcaaaagg agaataaata tggggaaaac 3118681 aggatacatt ggtgctgcca ttgttgtggc agcttgtatc attattttgt cggccgtggt 3118741 atgtttacgg gacacagtct attaccagcc tatgcgctgg actggcatca tactgttttt 3118801 cgcgggaatt gtgatggttc ccgcatactc agcaaaaaga aaacccggaa aagagaagta 3118861 attctctttt ccgggttttt atgtttatta taatcttccc gcgcgaatat cgtctgtcat 3118921 tccctcataa ggagccttcg aaatcacttc ttcgttgtcg actccttcat ttttcagaaa 3118981 tgtaatttcc gcaaattcag gtacaacgta ttttggatac gtttcatatt tttcgcggga 3119041 ttctttcatc aaatcaatgt ggtcattttg gtagcaaacc gtaatttcag gatgttcatg 3119101 cacccatttc gggaagaaaa taatgccatg catgcgtttt tcatttggca taaagtttaa 3119161 tgaaacatcc gtgccagtcg gctctgtcca agacacttta tatacgcctt ctgtcagttt 3119221 gacaatattc acttcctgat ctcgaaccca gcgtccggca accattccgc tatgaattct 3119281 ataatcaatt gtatggtcgt ttttaatata aatctcgtat tcccatccgt tttcatacgt 3119341 ataaatcatg tggcttccga taaagttttc catcttacac actctcctta gtcttttact 3119401 gtacttcata aatgtctagt agaacgtaat caggggttct ttctgcggaa ccgataaaca 3119461 agcggtcatg gagccattga tagacttcac tgcctgtttc aaacgtcggt accgtacgaa 3119521 aataaacatg ctccggttca ataatttccc cggctgccgc ttgttttcga aacggcttgc 3119581 tgacttgccg tattccattg ttttcaatgt aaatcagttc atgatctgct gtttcaatca 3119641 catacctggc agataaatct gttctgccgt tagcgcgaat catttgtgaa tcggcaccgc 3119701 ccggcaaaat acgtcccttt acttccccgg ttattgttcc cgaacgaatc ggaatgaatc 3119761 atctcagtcc caggcttgtc tcaccaatcg tgataggcgg atcaaccttg atttctaaag 3119821 aggcgaatgg ttttaaaacc ggcttcttca cgagaaccac ctcaccttca gaaaaaatca 3119881 tgtaactatt tacatgttca ctttaacacc attgcagtta actgtcaaac aataggaaca 3119941 taaaaaaaca aggactgttt gaagacagtc cttgtctgaa gctagctttg ataagcaaga 3120001 tatgtgctga cagtgctttt ggcaagacag gcagaggaat ctataatcgg aatctcactt 3120061 tgaatatgat ctaacaccgc atttaaatcc gtgcaggctg aaatgatgat gtctgcatgc 3120121 tgactgattt cttcatatag cgtctgccac aatgcttgtg tatgctgcat atgatttggc 3120181 tgtttgattg cggcgataag ctggttcaca gcctgctgcc aatggtcctt gtgaataact 3120241 tcttgtccat ttcccttcag aactttttgg tagatggcgg attggatggt tggctctgtt 3120301 cctaaaacca ccgctttttt tgcgggatgc ggaatctctt ttatcgtttc ctcaacaata 3120361 tgcaacatag gaactgacaa tgcctgctga atctcttcat agtagacatg cgccgtatta 3120421 caaggcagcg caatgaaatc cacgcctgtt ttctcgagct ttaccgctcc gtcgataatc 3120481 gcttttttca tctcgtcatg gtcaattgga cgatctgcat agaagggcgt cgggcatgaa 3120541 tagatcatca tgtgcggata gtcaatatcg tttgaagccc catacagctt ctgacagtaa 3120601 tcaatcacct tatcaataaa cggcgaggtc gatttcggcc ccattccggc taatattccg 3120661 atcatcaaat tcattccttt ctacttcgta cggaccgctt cttcctctga gccatcctca 3120721 tagaggataa agcttttcgc agcatcctca cctaatgtaa actcgacttc aacagacaat 3120781 gctcgcagaa agaaacgggt ttccgaggaa ggaaataact ccagtctcag ctgtccggcg 3120841 atctccaaat aaagccgttc attctcggtt gtcacctgtg cagccgtccc atcctgcaac 3120901 aggtagctgc caacatagcg gctgtatatc gccgtatcaa ttgctttttt ctttttatca 3120961 gcaggacgtt ccgggacatc atatggctgg ccaaatagaa tatgttccgc cgccttcaga 3121021 atcgcttgtt catattcagt atcctcttcc ttattactca aatagatcag cgttttacga 3121081 tgatcgatat atcggatcat catcgtcgaa tagccgggcc atcctccgct gtggctgaca 3121141 atccgccctt tttcaggact gttttgcagc acccagccaa agccataatc aattgtttct 3121201 ccattgttga ggcgcactgg agaaaacgca gattccttag aagccttgct gatgaaatcg 3121261 tcctgatata aagcctgatc aaatcgaaac aaatcgcttg tgacagagtt aaccgtccca 3121321 tctccctgta tgccatcgag atacacaaca tagttcgttt cctccagctc atcagggagg 3121381 acgtatgttt cggaatgtac atcatacaca tatccatatg cataatgatc aattcgctca 3121441 ggcgaaagcc tcctgttata cactcttgtt tcattcatgc ctgccggtaa aaaaatactt 3121501 gtttttataa aatccgcata gctcatgcca gatgcttttt caatgataac cgccagcagc 3121561 acataccccg tattgctgta catccagcct tcattcggtt caaaataacc agatagcccc 3121621 tcattcatca gcatatcgac aatatcctga ttcaccgcaa tcttgtgtga atcccaattg 3121681 gcaaaaaacc atcccatata atcaggaagc cctgacgtat ggttcaataa atgccgaatc 3121741 gttacgccct gatacggaaa accgggcagc cagcgatcca ctttatcctc atagccaaga 3121801 atccccttct cctccagcaa gatgattccc aatgctgtaa aaggctttga caaagacgct 3121861 aactcaaaca aagagttggt tttcaacggg cgtttttccg tcatttccgc atagccaaaa 3121921 gagtggtgat ataaaatatc gccaccctcc gcagccagaa ccgtcccgtt aaactgatgt 3121981 ttttcgccta atgtctcaaa taacgtctga agatgctttc ttttattctg cttcattcct 3122041 ccacctccca tatctctgta cgttactaac ctactaacgt ttcaaatatt ttgaaaaatc 3122101 cttcagttag agatcctttt taacccatca catatacctg ccgttcacta ttatttagtg 3122161 aaatgagata ttatgatatt ttctgaattg tgattaaaaa ggcaacttta tgcccatgca 3122221 acagaaacta taaaaaatac agagaatgaa aagaaacaga tagatttttt agttctttag 3122281 gcccgtagtc tgcaaatcct tttatgattt tctatcaaac aaaagaggaa aatagaccag 3122341 ttgcaatcca aacgagagtc taatagaatg aggtcgaaaa gtaaatcgcg cgggtttgtt 3122401 actgataaag caggcaagac ctaaaatgtg taaagggcaa agtgtatact ttggcgtcac 3122461 cccttacata ttttaggtct ttttttattg tgcgtaacta acttgccatc ttcaaacagg 3122521 agggctggaa gaagcagacc gctaacacag tacataaaaa aggagacatg aacgatgaac 3122581 atcaaaaagt ttgcaaaaca agcaacagta ttaaccttta ctaccgcact gctggcagga 3122641 ggcgcaactc aagcgtttgc gaaagaaacg aaccaaaagc catataagga aacatacggc 3122701 atttcccata ttacacgcca tgatatgctg caaatccctg aacagcaaaa aaatgaaaaa 3122761 tatcaagttc ctgaattcga ttcgtccaca attaaaaata tctcttctgc aaaaggcctg 3122821 gacgtttggg acagctggcc attacaaaac gctgacggca ctgtcgcaaa ctatcacggc 3122881 taccacatcg tctttgcatt agccggagat cctaaaaatg cggatgacac atcgatttac 3122941 atgttctatc aaaaagtcgg cgaaacttct attgacagct ggaaaaacgc tggccgcgtc 3123001 tttaaagaca gcgacaaatt cgatgcaaat gattctatcc taaaagacca aacacaagaa 3123061 tggtcaggtt cagccacatt tacatctgac ggaaaaatcc gtttattcta cactgatttc 3123121 tccggtaaac attacggcaa acaaacactg acaactgcac aagttaacgt atcagcatca 3123181 gacagctctt tgaacatcaa cggtgtagag gattataaat caatctttga cggtgacgga 3123241 aaaacgtatc aaaatgtaca gcagttcatc gatgaaggca actacagctc aggcgacaac 3123301 catacgctga gagatcctca ctacgtagaa gataaaggcc acaaatactt agtatttgaa 3123361 gcaaacactg gaactgaaga tggctaccaa ggcgaagaat ctttatttaa caaagcatac 3123421 tatggcaaaa gcacatcatt cttccgtcaa gaaagtcaaa aacttctgca aagcgataaa 3123481 aaacgcacgg ctgagttagc aaacggcgct ctcggtatga ttgagctaaa cgatgattac 3123541 acactgaaaa aagtgatgaa accgctgatt gcatctaaca cagtaacaga tgaaattgaa 3123601 cgcgcgaacg tctttaaaat gaacggcaaa tggtacctgt tcactgactc ccgcggatca 3123661 aaaatgacga ttgacggcat tacgtctaac gatatttaca tgcttggtta tgtttctaat 3123721 tctttaactg gcccatacaa gccgctgaac aaaactggcc ttgtgttaaa aatggatctt 3123781 gatcctaacg atgtaacctt tacttactca cacttcgctg tacctcaagc gaaaggaaac 3123841 aatgtcgtga ttacaagcta tatgacaaac agaggattct acgcagacaa acaatcaacg 3123901 tttgcgccaa gcttcctgct gaacatcaaa ggcaagaaaa catctgttgt caaagacagc 3123961 atccttgaac aaggacaatt aacagttaac aaataaaaac gcaaaagaaa atgccgatat 3124021 cctattggca ttttctttta tttcttatca acataaaggt gaatcccata tgaactatat 3124081 aaaagcaggc aaatggctaa ccgtattcct aaccttttta ggaatattgc tgtttatcga 3124141 cttatttcca aaagaagaac atgaccaaaa aacaaaatca aaacagaagc cggactaccg 3124201 ggcggcatat cattttacga cgccggataa atggaaaaat gaccctcaaa aaccgatcta 3124261 ttttgatggc aagtatcatt atttctatct atataaccgg gattacccaa aaggcaacgg 3124321 cacagaatgg cgccatgccg tctcagagga tttggtgcac tggaccgatg aaggcgtggc 3124381 gattccgaaa tatacaaacc cggacggtga tatttggacc ggttccgtcg tggtggataa 3124441 agagaacaca gccggcttcg ggaaaaatgc gcttgtcgcg attgtgacac agccctcagc 3124501 caaagacaaa aaacaggaac aatatttgtg gtacagcaca gataagggaa aatcattcaa 3124561 attctacagt ggcaaccccg ttatgcctaa tccgggcaca gacgatttca gagatccgaa 3124621 agtcatatgg gatgaccaag ataacaaatg ggtcatggtc atggctgaag gatcaaaaat 3124681 cggcttttat gaatccgata atcttaagga ctggcattac acaagcggat tcttcccaga 3124741 acaggcggga atggtggaat gtcccgacct ctacatgatg cgggcaagcg acggaacgaa 3124801 taagtgggtt ctcggtgcca gcgcgaatgg caaaccgtgg ggcaaaccaa atacgtacgc 3124861 ctactggacc ggaagcttcg acggaaaaga attcaaagcg gatcagactg aagcccaatg 3124921 gcttgactat ggcttcgact ggtatggcgg tgtgacgttc gaagacagca aaagcacaga 3124981 tccattagaa aagcggtatg cgcttgcctg gatgaacaat tgggattatg ccaacaacac 3125041 cccgacaatg aagaacggct ttaacggcac agattctgtc atacgcgaac tccggctgaa 3125101 ggagcaggat ggaacataca gcctcgtctc acagccgatt gaagctttgg agcagctgac 3125161 tgtttcaact gacgaaatag aggatcagga tgtgaacgga tcaaaaacat tgtcgataac 3125221 aggtgatacg taccagcttg atacggatct ttcttggtca gagctaaaga atgcaggcgt 3125281 caggctcaga gaatcagaag accaaaaacg ccatattgat gtcggcattt tcgctgaagg 3125341 cggctatgct tatgtcaata gagcagccac aaatcagcct gacaaaagca atacctatgt 3125401 cgaaagcaaa gctccttatg atgtaaacaa acgtaaggtg catttgaaaa tacttgtcga 3125461 taaaacaacg atagaagtat ttgttggcga cgggaaaacc gttttttcaa atgaagtctt 3125521 cccaaagcct gaagataaag gaattaccct ttattctgac ggcggcacag cctccttcaa 3125581 aaatataaca gtgaaacact ttgattcgat tcatgaataa aaacaggggc ggcgcaggct 3125641 gcccctgttt ttttattagg agcggtattc tctgttacat attgggcatt gtaaggaata 3125701 taaggctggt ttcaaaggag gaagcgaatg tctaaacaag gaaattttca aaaatcaatg 3125761 tcgctgtttg atctgatttt gattgggatg ggagccatct ttggatcagc gtggctgttc 3125821 gctgtcagta atgtcgcttc aaaagcaggg ccctccggcg ctttttcctg gatcctcgga 3125881 ggagccatta ttttgttaat cgggcttgta tatgcggagc tcggagccgc tctgccccgt 3125941 accggaggca tcattcgata ccccgtttat tcacatggcc accttgtcgg ctacttaatt 3126001 tcgtttgtca cgattgtcgc ttatacaagc ttgatttcaa ttgaagtgac agctgtgcgc 3126061 cagtatgtgg cctattggtt tcccggcctg accattaaag ggtctgattc gcctaccatt 3126121 tccggctgga tcttgcagtt tgccctatta tgcttgtttt tcctgctgaa ttattggagc 3126181 gtcaaaacct tcgctaaggc gaatttcatc atatcgattt ttaaatatat tgtgccgatt 3126241 accatcatta ttgtgctgat ctttcatttt cagccggaga atttatccgt tcaaggattt 3126301 gcaccgtttg gatttacagg tattcaggct gccatctcga caggcggcgt catgtttgcg 3126361 tatctcggcc tgcatccgat tgtatctgta gcaggtgaag tccaaaatcc aaaacgcaat 3126421 atcccgatcg ctttaatcat ttgcatcatc gtttcaacca tcatttatac tgttttgcag 3126481 gtcaccttta ttggtgcaat cccgacagaa acactgaaac atggctggcc ggcaattggc 3126541 cgggagttct cattgccgtt taaggatatt gcggtcatgc tcgggttagg ctggcttgca 3126601 acgcttgtca ttttagacgc cattctgtct cccggaggaa acgggaatat ctttatgaat 3126661 acgacatccc gccttgttta cgcctgggcg cgtaacggca cattatttgg catattctca 3126721 aaggtcaata aagatacggg gacaccccgc gcttcgcttt ggctttcgtt tgccctgtcc 3126781 attttctgga cacttccctt tccttcgtgg aacgcgctcg tcaatgtctg ttcagtcgcg 3126841 ctcattcttt catatgcgat tgcacccatt tcttcagctg cgctgagggt caacgcgaag 3126901 gacttaaaca ggccgtttta tttaaaggga atgagcatta tcgggccgct ttcctttata 3126961 tttacagcgt ttatcgtgta ctggtcagga tggaaaacag tctcctggct gctcggttca 3127021 caactcgtga tgtttttgat ctatctctgt ttcagcaaat atacgcctaa agaagatgtc 3127081 agccttgctc agcagctgaa atcagcctgg tggcttatcg ggttttatat tatgatgctg 3127141 atcttttcct acatcggttc tttcggacat ggtttaggga ttatcagcaa tcccgtcgac 3127201 ctcattttag tcgcgatcgg ctcacttgcg atttattact gggcaaagta taccgggctc 3127261 ccaaaagccg ccattgatta tgataaataa agaagcaaga ggttttcttg cttctttatt 3127321 ctttacaaac aaacatacac gcgataaaat gaatgagagt cagtcattac tggaggtgtt 3127381 cctcatgcca aaacaaacat cgggtaaata cgaaaaaata ttgcaggcgg ccatagaagt 3127441 catttctgaa aaaggcctcg acaaagcttc tatttctgat attgtcaaaa aggccggcac 3127501 tgcccaagga acattctatt tgtatttttc atctaaaaat gccctcatac cggccattgc 3127561 agaaaatctc ctcacccata cacttgatca aatcaaaggt aggctccatg gggacgagga 3127621 tttttggacc gttttagata tattaattga tgagacattt ctcattacag aacgccataa 3127681 ggatattatt gtcctctgtt attccgggct tgcgatcgac cactccatgg aaaaatggga 3127741 gacgatctat cagccttatt attcctggct tgaaaaaatc atcaacaagg ccattgcaaa 3127801 ccatgaggta acggaaggaa tcaattcaaa atggacggcc agaacgatta tcaacttggt 3127861 cgagaatact gcggaacgat tctatatcgg atttgaacaa gatgaaaatg ttgaagtgta 3127921 taaaaaggaa attttcactt tcttaaaacg gagcttaggt actgcttaaa aaatgactgg 3127981 gtaacaccgc tcatttttta atgccctaaa aatgactgac gttcattcat aaaatagaga 3128041 ggtgtttcat ttgaattggg ttcttgtttt tattgcaggg cttttagagg ttgtttgggc 3128101 ctcttccctc aaacatgccg attcgctttt ggattggatc atcattttta tcttaatcgc 3128161 ggtcagcttt atcctgttga tccgctctta tcaaaaaatc ccgatggccg cggcgtacac 3128221 tgtgtttgtg ggaatcggaa ccgtcggaac atatctgact ggaattgttc tgggcgaatc 3128281 cttctcagca gcccaaatgt tctttttagc tttattgctg gctggcattt taggaatgaa 3128341 attatttacg aaagaaagca aatctcagcc gggaggtgaa aaataatggc atggttttta 3128401 ttagtgattg ccggcataga agaaattata gctgccattg ccatgaaata tatagacgga 3128461 acaagaaaaa aatggccgat cattgtgatg actgttggat tcggcttatc cttttactgc 3128521 ctgtcccaag cgatgatcgt cctgcctgcc ggagtcgcat atgccgtctg gactggcatt 3128581 ggaagcattg gtgtttcggc ggtcgggctc atctggttta aggagcggtt tcagctttca 3128641 caggtgattt cactttgcct tatcctagcc ggcgtcatcg gcctgcgtct tacgtcatct 3128701 tcataaaatc aaggcatata cagctgtata tgcctttgcc attaagcttc gtgatgtttt 3128761 tgaagatgaa gcggcggcgg gatgagccag cctttgtttt ttagcagcct taagtatttt 3128821 gcgccggttg ccgctttcga catatgaaat tgcccaaaca tcatggcaat atcctcacga 3128881 atcgattgcc ccatcatttt gctgcatgtc acaagacctg cagcattttc tgctgccgcg 3128941 gaagccgcca catccggatc gagaaaccgt gcaccaggcg gaatatcgtt aagatctgct 3129001 gtcggcggtt caggagaagc cggcggcagc gccaccccgt tttctttcag gatcgtgctg 3129061 acctgtttga tttcatcttg gcatttctca atagactcac gaagcagctt cttcaggtcg 3129121 tcatcaccga catgattcaa tagcatttgg taattgccga ccattttatt gcccgccatc 3129181 acataactcc acaagccgaa tacctcaccg taatgcatcg gttcatcctg cggatttccg 3129241 cttaaaatac ccatgctcat tctcctccca tattcaatat tgcacatttc ataacgtgcc 3129301 caagcggagg aacatttatg tttcagcgga aaagatttat gaaatgaaac aaaacaaaaa 3129361 agacaagagt ggcaagttgc caaaccattg tctttcctgt tgtttgattg gacgcactga 3129421 agggattcgc accccgacag acaagatacc ggaaaccatt caagtgcttt ttagtatgag 3129481 tcattgattc tgtctttaat aaactttaac gagatggcgg gatgctttgc ggaaaacgaa 3129541 atacattttc ggggtcatat ttcgccttta tttctcgaag ccgcgcaaag tttgcgccat 3129601 aatattcttt tccgaagttt tcaatgtttt gatctggaac attaacatat gaacctgcta 3129661 catatggttg catcagctga cgcactcttt caactgatgc aagatttgaa tcttcttgtg 3129721 atttattttt ccaactagcc gtccattccg tataaaataa tggatggcgc caaaaaaagg 3129781 cagtttcgtc tttagggact ctgcttatag caccacccca attgataaaa aagaaattgg 3129841 cttctgttcc agtagcatct tccaaaaatt ttctcatgat tgaaatgggt tcgtcagacc 3129901 aaaaatcatg accccatgcc gaggagaatt taacactctg atcatttctg ccagggatgg 3129961 gttcgtcagg gtctaagaaa tctatagcat ctggatagta taatgttttg atatctgctt 3130021 ctgttggagt tcccgcatgt aataaaggtt ttaataatcg aatcaattca gttttcgaac 3130081 cgaggaaaat tccttctgca tgacacaaac catttatttt gctgtaaatt tcaaggtagc 3130141 atcctaatcg ttcatctaca aacggagccc atttctgcca agctttaaat accgtttcta 3130201 attgttccca cggccagata atattgaaga cggttgcagt tttaggggca cgatgaactt 3130261 tgaatgtata ttgggtatta tatccaaagt tacctcctcc tccgcctcta gaagcccata 3130321 gcaaatcctc attgtgagat tgatctgcgt gaataatcct tccttttgca tctaccgttt 3130381 tcagcgcgag aaggttatca cttataaggc caatcgatcg tgagagtaca ccaaatccgc 3130441 cgcccatcgt aattcccccg attccaactg ttgggctatc tccaaacgga gccataaaac 3130501 cgtctcgagc taatcccttt acaagcgggc caacgggaat accagtttga acggttgcaa 3130561 tagcgttttc ttcatctaag aaaactttat tcatgtcact cacatcaata acaattcctc 3130621 cacttactac tgaaaggttc ttatctaaag catggcgacc gcttctgaca cgtaagggca 3130681 ctttattctc acgagcccat ttaatggcat tacttacatc gtatgaattt tgcgcaaaaa 3130741 caaagacaag aggatagaca tccacataag ggttccaatt cttaatagcc tctgtatagc 3130801 cggggtctcc tttgaagatt acacgccctg tcaactgtgt tgatcccata tattatttca 3130861 ctcccaaaga aattcgattc agatactaaa atatgcagga gctggataat cgcatagaca 3130921 aatgatctac gaactataaa tataatacgc taaggccttt ttcgtcggtg aggtctgctg 3130981 agaaacattt ttcaaacaat tttgagcaaa cttcctgtcc aatcctccaa caagcgtttt 3131041 ttcttatcgt ttttaggagc agtgtccagt ttttttcgga gtgaatattc gtttaggcca 3131101 aaagaaaaga gagatgaaga agtgtttagt accagaggta tacatccata caacagactc 3131161 tagatcatca tatactgaat gtatgtagaa aggagacatc agctttggca aaatatcgga 3131221 ttatgacctt tgacggcggc ggtaccttag gtgctttaag tttacaacta ttaaacagat 3131281 tggctaggca aaacccgaag ttaattagtc gaacccatgt attttcggga aattcaatcg 3131341 gttcatttac tgcccttgca ttagcaagcg gaagatctcc gagggaaaca cttcagtatt 3131401 ttgaggatga aatcctaccc gcattcagca tttcccggcc aggcggacct gttttcaacc 3131461 aacaattacc ctattccggt tttattaaag cggtaagaaa ttttttccca gcagatcttc 3131521 aacttataga tttaagaaaa cgaattgttg tcccatcatt caaattatac tctcaaaaac 3131581 tggaccgttg gactcctgtc ttatttcaca attttcccgg ctctccctat ttaaatgaaa 3131641 aagtgagtga tgtcatactg cggagcagcg gtgctcccgc gacgcaacgc gcctatcaaa 3131701 actatgtgga cggatatgta gtagcaacga atcccagtac agccagtatc gcgtttgcag 3131761 ttggtaaagc caacgtgcca ttggatcaaa ttgcggtatt gtccatcgga acaggtgaag 3131821 ccccgactcg gttaagaaga gatacgaggg gatggggaat ggtaagtgca gataacatac 3131881 gtcccgaaaa tctgaagaac cttcctccaa attggggagt ccttttggac aggtcgccta 3131941 atgaaccttt actgccattt cttcagatga ttgctggcgg taatgggtac tatgaatcca 3132001 tggtcagtgc gaatcttctg ggagatcgtt ttttccggtt agatccgcgg attccgaact 3132061 tctccaaaac ggaccctgcc gtcgttcccg ctgtcattga aattgcgaac aaaacaaact 3132121 tacagcctgc gaatcaattt atagagaaga actgggggag caaataatta tttattttaa 3132181 atcaattctc gcttatacaa ttttgtccga gagaagattc tcaaaataaa tacaggcaat 3132241 gggtagaacc ggattttttt aaaggtttgt taatcacaag ctaataagat gaatgaaaaa 3132301 atcaattcat acttcttctt ttgaaagtga gggttcaaac taaagaatgt aattgaaatg 3132361 ttactctaag gtatgcaatt ccctttttca cacaaaaaaa gacaagagcg gcaaatcgcc 3132421 aaacccttgt ctttcctgtt gttctattgg acgcgctcgg agggattcga acccccgaca 3132481 gacgtggtac cggaaaccac cgctctatcc aactgagcta cgagcgcata tagactgcgt 3132541 tatgagaacg tcagcacaac taattatacg ataattcctt tcaaataaca accctctatt 3132601 tcgagaggcc gttttttaaa tagacaaagc atcttaattg gcaatctgac atacgatggt 3132661 ttgaacccct gtatttttgg ggaaaatggg aaaaagagac gactttgcat atcaggccag 3132721 ctttttgttt gacctttatt gaccaaaaat gtatcatgta actacatact tacctaaaag 3132781 gtgaaggagg agcattatga atttaatacc tacagtcatt gaacaaacga accgcgggga 3132841 aagagcgtat gacatttatt ctcgtctatt aaaggatcgt atcatcatgc ttggatctgc 3132901 gattgatgac aacgttgcga actccatcgt gtcacagctt ttattcttag cagcagaaga 3132961 ccctgaaaaa gaaatttctc tttacatcaa cagcccgggc ggctctatta cagccggtat 3133021 ggcgatctat gataccatgc agtttattaa gccgaaggta tctacaattt gtatcggtat 3133081 ggctgcgtca atgggcgcgt tcctgcttgc agccggcgaa aaaggcaaac gctatgcgct 3133141 tccaaacagt gaagtcatga ttcaccagcc tcttggcggt gcgcaaggtc aagcgacaga 3133201 aattgaaatt gctgcgaaac gcattctctt gcttcgcgac aaattaaaca aagtcctagc 3133261 tgaacgtact ggccagccgc ttgaagtgat cgaacgcgac acagaccgtg ataacttcaa 3133321 gtctgctgaa gaagcgcttg aatacggcct gattgacaaa attttgactc acacagaaga 3133381 caaaaagtaa taacacaacc tgcaagagct gcgtctcttg caggtttttt tcatttcaag 3133441 gaattgactc ccttattcta tactgctccc attcctcatg taacagctca agcgtcaaat 3133501 cactcgtctg cctcacaacc agatcagcac caagcatcgg ctgtccttga ccgacaccaa 3133561 ccgcaaacat ccccgcagat ttgattgcag aaatgcctgc ttctgcgtct tctattgccg 3133621 cgcaatcagc aggggaaaca tcgagcatcg ctgcagctgt taaaaagatg tcaggatcag 3133681 gcttcccctt cgcaagagtc gtcggatcaa caatggcatg aaaatcatcg ataattgcca 3133741 agcgtcttaa aatcttagga gcattgcgac ttgaagatgc taacccgatt tttatatttt 3133801 cgtttttcaa ttgacataga agcctgccaa tccccggtaa aagatcttcc ggcgtcaatt 3133861 tgctgatcag catttgataa tcgcgatttt tccgatgcat aagctcttgt ttctccgcat 3133921 ttgtatactt tgtttccgcc ccgccaaaga tcaatatgct ttcaagtgac tcttctctgc 3133981 tgattccttt tagcctttca ttcatgtctc tgtcaaaagg gatatcgatt tgttctgcga 3134041 tgtgcttcca agcgagaaaa tgatattcag cagtatctgt tatcactccg tctaaatcaa 3134101 aaatgaccgc tttcatatac taatgcccat cacagcttca taaggtttga ggctaatact 3134161 ctttaagtca gcccgctcct gcggatagtt tgaaattagc actttccaac gctcatgaat 3134221 cagttctgga ggcgcttcga acagagcctt ttcttccgat aaattcacaa cgacaagaag 3134281 cttttcccct cgatattctc gaaggtaaga aaagacctgc ggatcattct cctgcaacag 3134341 ctgataatcg ccatatatca taatcttata ttgctttcgt aattgaatga gcttctgata 3134401 gtaaaagaaa atcgaatctt gatcttccaa agactctttc acattgatat cttgatagcg 3134461 ggaatttacc ggtatccacg ggtctccggc tgtgaatccc gcatgttttc cggcatccca 3134521 ctgcatcggt gttctcgcat gatcccttcc ttttatcatc acggctttga caaactcttt 3134581 ttctgacatc gttttgtttt cgacgactag ttcacgatat gcattcttta tttcaagatc 3134641 atcatacatc tccagcggca tatcgctgtt gaccatgccg atttcttctc cctggtaaat 3134701 aaacggcgtt cctttcatgc cgtgcagaac cgttgcaaat gccttcgcac attccttacg 3134761 cagtttcctg tcattgcccc agcgggaaat aaccctcggc tggtcatggt tctcaaaata 3134821 aagggtattc cagccgacat tcattaaccc ggtctgccac cttgtcatcg tcttttttaa 3134881 agcaatcaaa tcaaacggct tgatctgcca tttcccattt ggcgagtttt gttctttatc 3134941 aatatccata tgttcaaatg taaagatcat attcagctct tgcctgcttg catctgtgta 3135001 ctttttcgcc tcttcaatat cagagccgtt tgcctctccg actgtcatgc agtcgtaatg 3135061 agaaagcact tccctgttca tctcttgaat aaactcatga agacgtgggc cgttagagtg 3135121 ataacggccg acaatatagc tgcggctgtg atccgtttcg tagtccggaa aatcggtgta 3135181 tttagaaata gagccaatca catccatccg ccagccgtca acgcctctat ccatccagaa 3135241 tctcattaca tcataaactt cccggcgaac ggcttcgttt tcccaattta aatcaggctg 3135301 ttttttcgaa aagtagtgca aataatactg ccctgttcct tcatcgtatg tccacgctga 3135361 gcctgaaaag atcgatcccc aattattcgg ctctgagccg tccggtttag gatctttcca 3135421 aagataataa tcccggtaag gattgtcctt cgacttgcgg ctttcagcaa accaagcatg 3135481 ctcatctgat gtgtggttca cgaccaaatc catgacgatt ttcattccgc gtttatggac 3135541 ttcatcaatc agctgaaaca tatcttcatt tgtcccaaac ttttcgtaca tgtttttgta 3135601 atcgctgata tcatatccgt tgtcatcctg cggggaatca aataccgggg agagccagat 3135661 gacatccgcc ccgaggtttt tgatgtaatc cagcttttga atcacacctt gcaaatctcc 3135721 gaatccatct ccattggcat cataaaaact gcgcgggtaa atttgataaa cgacagcttc 3135781 tttccaccat tcactcatta ggcgttctcc tttcacatcg tccctgtagg acaaccggtt 3135841 cctcataaac gttcatgtgc agcggctcgc cttttacaag ctcaaaaata acgcgctttt 3135901 cgtcaaccgt cacattgatt aatcgatttc gataattgat gttgaatgaa tattcgtccc 3135961 attctttcgg caaaaacgga gcaaatgaca gcgtctcatt cgcggtgcgc atgcctgcaa 3136021 agccatgaac gattgccagc cagctacccg tcattgaagt aatatgcaag ccttcttccg 3136081 tatcatgatt gtaattatca agatcaagcc ttgctgtgcg cttatataat tcgagcgctt 3136141 tcttttccag cttgagttcg gctgcgagaa tcgcatggac agagggcgat aggcttgatt 3136201 catgaacagt catcggctca taaaattcaa aatttcgccg tttttcttcc attgtaaaac 3136261 ggtcattaaa aagataaatg ccttggagaa catctgcctg cttaataaaa ttggagcgga 3136321 gaatcttgtc ccatgaccaa ttctggtaaa gaggccgttc cgctggatct aattcgtcaa 3136381 ctgtttgcag gtctttgtcc aagaacgtgt catgctgaac gaaaatttgc agttcttcac 3136441 taaatggata gtacatgtgc tggatgattt ctctccagac ttccaattct acttcctgca 3136501 catccagatg gcggcgtttc tccgctgaga tactttcgag actttgtaga gtatactcca 3136561 acgtccaagc cgcaatgaca ttcgtatacc aattgttgtt aacgttgttt tcgtattcat 3136621 tcggccctgt gacgccatgg atcatatact tattttttcg tttcgagaag tgaacacggt 3136681 cggcccaaaa tctgctgact gccacaagta cgtctatccc gtattcttcc atatagttac 3136741 ggtcgcctgt ataattgata taattgtaga tcgcataaca gatcgcgcca ttgcggtgaa 3136801 tttcttcaaa ggtgatttcc cattcgttgt ggcattcatc acctgtgaac gtcaccatcg 3136861 gataaagtgc ccccttcatc cccaattttg cagcgtttcg tttggcagcc tccaactgat 3136921 gatagcgata caaaagcagg tttttcgtca cctccggctc ggctgtcgcc aaatacatcg 3136981 gaacggcgta cgcctcagta tcccaatatg cggcacctcc atatttctcg ccagtaaatc 3137041 ctttcggccc gatattcaaa cgggcatcgc ccccgtaata tgtcgagaat aactgaaaga 3137101 tattgtagcg gattccttgt tgaagctcct catctccttt aatctcaatg tccgcttttg 3137161 cccatctttc cttccatcga tcagtgtgcc tccgttttgc atcttcatag ccgttctcta 3137221 ccacatccgc caaaagctcc ttggctttcg ataaaagctc ttcctcccga aaatcacggg 3137281 aagtcgtgac aatcacaaac tttttcaatg atgccttcgt ttgataactg tagcgattct 3137341 cgacatacat ttcagtcgtt ttaaagcttt catggacaaa accctccgtc tcgtttgcca 3137401 ttgcggctaa taccgtgaag cgcggtgttc caaatggatt ttcgatcgtt tttgccgcta 3137461 aatggccgct gtgagaatca gcacctttcg cttcctcctg ccaaaactgt tcttggtagt 3137521 tagaatcttc atttgccaca tttccatcca ggtaaggaac aagcgtaatg acagcatctc 3137581 ccgtcaagca ctccgcttca taatgaatcg cacagagttc ttttacagca aggctaagaa 3137641 accgctctga cctgattctg acggttttat cttgaatgcg gacaacagcg cttcgccgca 3137701 gaatcccctc tttcatattg agttctacct caaataattc gattgggttt tgatggagat 3137761 cgattttttc accgtcaaca tataggccta tgcccataaa gttcatcgca ttgatcactt 3137821 ttccgaaata ttctggatac ccgtttttcc accagcctac tcgcgttttg tcggggaacc 3137881 acacgcctgc aatatatgtg ccttggtgac tgtcgcctga atagccttct tcaaaattcc 3137941 ctctgacccc catatagcca ttggcaagag acgtcaggct ttccagcagc cgtgtatgct 3138001 ccttattaaa tgtatttgtt ttgattttcc attcatcaat ctcaaataac cgctgattta 3138061 tcatcatttc ctcccgaatg taagtttcca ttatcacggc gggttttggt caaatatcta 3138121 aatgcaaaag agatcatcaa agtaacgcca cacgaatgga tcatcaatac agtaatcaaa 3138181 tcaaaatgaa ccatgccgat agcagctgcc gcaaatgccg gcagtgctga tgcgcaaatc 3138241 gctatagagg ccgcttcctt gaatgatgca atagagacca tgtttgatat ttttgtgatc 3138301 cagaggccac ctgcaagaac aaacgttaac aaaagctgga tcatagaaac caccgtatat 3138361 gccagcatca tgatcatcgg cttatactgt gccaaccaca atgtatcgat caagacctct 3138421 acatcatgga cgtttggttt ctcgagctta acgtccattt tcgcatagcc aacagaaaac 3138481 cccgtttcgt tttgatcggt gatcaccagt tgatcaggtt gaaatatgat ggcgttttca 3138541 aatccagtta ctttcaatcg cccattttca ccgcttgtct catattcatg cttcatatcg 3138601 actgccatca cattctgccc atcttcaatc ctctcagagc tcttcccgcc tgttagtttt 3138661 ccgttcctga tttgaaaacc ctgcaattga tcagcaaatt gatcattaac tccttgaatc 3138721 gctgacggca tgaaagatga aacgctgaag cgatccattt tcacaaacga aaccgctaac 3138781 ggcgccatta agcaggccgt taaaaacaga aagagaaaag agagctgcag ccagctgaag 3138841 gtattcccat agcggcaaac acctgatggg gatgcagccg ccttcaggca gcggatgata 3138901 aagcttttat tctccagatt cttcattggc attacccctt tgttccgccg gctgtcaaac 3138961 cggacacaaa gttcttttgg agaaaaaaga atagaacgca tatcggcagt gcggctagta 3139021 tggcaccggc tgcaaataga gctacttttt gctgctgcgg attagaaata aaggattgta 3139081 atcctacagc gatggtcagc ctttccggtg agcgaagcag aaatttcgtc agcaaatagt 3139141 cgccaaacgg tgccataaac gcccaaagcg cttgtaccgc gagcattggc ttaacaagcg 3139201 gtagaacaat tgaagcgaaa atcctcagat gtcccgctcc gtcaattcgc gcggcttcat 3139261 caatttctct cggcacagta tcaaaataac ctttcatcag ccacgtgttc atcggaattc 3139321 cgccgccgat atagatcgct gttaaaaacc agtattgatc gagtgcgcct attagcatcg 3139381 ccaagacata aaaagcagtc agcgccgcca ttgtcggcac catttgaatg attaaaaaga 3139441 atatcaggct cttttttctg cctgcaaacc gatagcggct gtacgagtac ccggcaagtg 3139501 tcacaatcgt aacctgcaaa accatgaccg atagcgcgat gacaagtgta ttgctgtacc 3139561 aattgagata aagcgtttcg tcaaatagcc gcttaaaatg atccaatgtc caagaacccg 3139621 aaaaatcgag ctgaaaagcc gccgaattcc ccacacggaa ggctgatgat gccgtaatca 3139681 gcaacggata tataatgaca atacttaaaa gcgtcaaaaa taaatacgta cagattttat 3139741 taagcattct ggcagtgctc gcgttcacct acataacctc ctcattgcca aaagcattcg 3139801 attttttgaa agcaatcagt gaaattccaa tgacaatgaa agaaattaac agtgtcacag 3139861 ccgccgcaac ggaatattgg ggtgatgtgc ctgttgtcag tttataaatc cacgaaatta 3139921 agatatcggt cgatccggcc ccggctcccg cactgcctgg ccctccctca ttaaataaat 3139981 agatgatcga gaaattattg aaattaaacg tatactgagt aatcatcacg ggtgctgtgg 3140041 caaataaaat catcgggaat gtaatatgcc gaaaacgctg aataaaagtg gccccgtcaa 3140101 tctttgccgc ttcatacaat tcacctggaa tcgcctgaag cactcccgtt accatgacat 3140161 atatatatgg aaagccgagc cacgtttgaa tcataatgag ggctgtcttt gtccagaaag 3140221 gatcggtctt ccacgcgatc gcaggcagct cgacaaacgg caggtgattg aataatggta 3140281 tcacctgtgc attcaccgct cctatgctgt cgttaaacat gttggaaaaa ctcatgattg 3140341 taataaacgc cggaacagcc catggaaata agaaaatcat tcgaaatatc cgcttgcctt 3140401 ttataaaatc ctgattgacg aaaagtgccg tcacaatacc taaaatgatt tgcagcgttg 3140461 ttgcacagat tgtccagata accgtccagc ccagtacatt cacaaatgtt tcacgatagg 3140521 agccaaggaa aaaaatattt aagaaatttt taaacccgac ccagtcaatc agacgattag 3140581 gcggaatatg ataaaaatca tagtttgtta atgcaacaaa cagagtcacc aaaaccggaa 3140641 aaataatcac aaacaccatc atgatatatg ccggcagtgt aaatagatac ggaaaacctt 3140701 tatcgcccgc atgacagatc atatccttgg ctgttgtatt gacttccaaa cccgccgctt 3140761 tcatagcggc ggtcttacgt gaatcatgaa tattaaagat atagaacatg aggaaaatca 3140821 ttgtcacgat caattgcagc gtgccttcaa tcagcataaa cagcgagtga tcttcaccgg 3140881 gaacacttcc caatgtcatc aatccggtta gcgcctgtat accgaaaacg cataattcaa 3140941 aagcaaacaa gcctgtgatg gcaagaaata agagcccctt tgacaactgc tgattcgcaa 3141001 tctgcccaag tcctggaatg atcgataaaa gccctgcctt tcgtttttgc tttgtaagtg 3141061 tgtgatgttt attcattttt ccgccctcta ttcttccgga cgctatcccg ccgttttatt 3141121 tcacatactt ttctttaata ttttccttta tgacgtttac agcatcattc gctgatgttt 3141181 gtgtcgattt ttttcctgaa gctgcatcaa aaattaaact ttccgctcct gtccatactt 3141241 cagccatttc cggaatattt ggagtcggcg ttgctgtttc atattgttta atcacagctg 3141301 acgtcagttc attcttttgc tcatcggctt tcttccttgc agccgtgttg gccggaactt 3141361 cgtttgtatc ctcataaaaa gcgtaagcat tggcatcatt tgcagcatac tcaagccatt 3141421 tttcagccag ctcgggctct tttgtatatt tcgaggcaac ccagcccttc ccgccagcaa 3141481 aaggggcgta ttcttctcca tttggcaatg tcggaatggg agccgctccg tagttcaatt 3141541 tagcctcttt atagttggca gctgaccaag gaccgccaat gatcgcagcc gctttgcctt 3141601 ctaaaaacat ctgctgaata aagtcgtctg cgcttgaatt gtcttgcatt cctttcggcc 3141661 aatatgtctc aaaccatttc tccgcatatt tcaccgcttc tacagcccct ttattgttca 3141721 ggccgatgtc cccggaatct gtgccgtttt ttccaaacac atatccgccg tatccagcca 3141781 ataagccgta cgacatataa aagtcagtcc attttgctaa aaatccggtt gattttcctt 3141841 tttccgaagc aaacgcgaat cgaggatctt ccgttaactt ttcaaggtct ttaaatgttt 3141901 ttggcgctgt ttttaaaaga tctttgttgt aatacaaaat aagtgtctca atgactagcg 3141961 gcattccgta cactttgccg tcaactgtca cctgctgcat ttctttatca ccaaagcttt 3142021 ttgtgttaga tggcttaata tcaagtaaat gtccttgttg tcccaaaccg ccgatccggt 3142081 catatgcagc aagcataaca tcaggcgcat tacccgccgg gccatcaaga ggaagcgctt 3142141 ctaactgttc gaacatttgc ttttcaacaa tttttactgt gacatcattt tctttttcga 3142201 actttgtttt tatgctttca atgtattctt tatacgtttc ttcgacagac acagtcagca 3142261 cctttttgcc atcagagctt gctggatttt ttgaacttga gcaggcggca aggccgattg 3142321 ccaggaatga tgccgccaat atggcgaacc ccttttttaa aagaaccatc tcttttcctc 3142381 cttctattta cgaaactata acaattgtat tgtcctatag aaagcggtta caacaacttt 3142441 cgatttgtta ccgataacag aatgttatac aggggcggca gcactcaaaa tcaaaaattc 3142501 tcccggctga acggcaatga catcgtgatg ctgtagcggc tgctctgtcc atgcatcaca 3142561 gattttctta ttcctatcaa tattcaactc tcgtaaactg acgtgttgaa ccacattccc 3142621 ttgattaaag aaataaatca gtattttttc atcaagagtc cgcgaaaagc taatgaaatc 3142681 atttttgtcg tccagcagat tccactcaag atgtccttca gtcaataaag tgttttcctg 3142741 cttgcgtaaa gcaattaacc gtttcataaa ttgcagcatg tcttggtttt gcttctcttt 3142801 ttcccaaacc atacatttcc ggcataatgg atcattttcg ccgttcagcc cgatttccgt 3142861 tccgtaataa atgcatggtg agcctgtctg ggcaaacata aaggccagca acgcgcgtgc 3142921 tttcttctca tcattgcggc atctggtcaa aaggcgcttt gtatcatggc tatccagtaa 3142981 attaaacatc acctcattgg cctgcttcat tccattcatc aaatgtgcat tgacacggtg 3143041 agccatacgt gaagctgaga tcgtctggtc agcaaagtat tcaatcatag gctctgtaaa 3143101 agggtaattc atcgccgcat gaaattcatc ccctctaagc cagggttcgg cagaatgcca 3143161 gatctcacct aaaatataaa catcaggctt ttcagtagat acagcctgcc taaatgtctt 3143221 ccaaaaaacg tgatccactt catttgcgac atccaaacgc cagccgtcaa tgtcaaattc 3143281 gcgaatccag tacaaagcaa tatcaagcaa atatttctgc acctcgggat tagccgtgtt 3143341 tagcttcggc atatcagctg taaaagcaaa tctgtcataa ttgtcgtctg tgacgggaaa 3143401 agagtgaata tggaaccagt ccttatagcg ggattgatct ccgtttttga cgacatcctg 3143461 ccattgcgga gacgcgcttc ctatatggtt aaaaaccgca tcaagcataa ttctcatccc 3143521 ccgctgatgc agctggctga ccaatgtacg aaaaagctca ggatccccga aatgcggatc 3143581 aatagaaaag taatccagcg tgtcgtattt atgattagaa ggcgcggaaa agatcggtgt 3143641 cagataaatg ccgttcaccc ctaaatcctc taaataatca agcttgtcaa caattccttg 3143701 taaatcccct ccaaaaaaat cattgacgtc cgggtccttg ctcccccacg gcaatgcatt 3143761 cttcggtgac aagtcttctc ttccatttgc aaaacgctcc ggaaaaattt gataccaaac 3143821 cgttgacttg acccattcag gcgcttgaaa tgtatcagcc tcgtgaacaa acggaaattt 3143881 aaagtaataa tgaatcgttt ccagtgtttt ttcgttataa gggcatacac ccgaacttcc 3143941 gaaaaagatg tcttcatgat cgtctgttac aacaaacgca tattgtaaac gcctaaatgg 3144001 cggcaccact tcagcaaacc aatagtcatg catttctgta gcagcaattt tcctcatcgg 3144061 ctgctcgttt gccgaccatt tgccgtcgtt gtactcatag ggatcacccc aaatgaatcg 3144121 aatgtgatct gcatcacctt ttttcgtccg aatcttgata tgcacagtcc gcccatcata 3144181 agaataagca tctgtgctga atggctggtg atgaatcgct gcatattcca tcatgtttcc 3144241 ccctttgatt tccgttttat tgaagccggc tcatagtttg aaagtatcat gatgaaattg 3144301 tgggaacaat ccttttcacc ctgttaccga taacagaata aggcgcttac agcgttgatt 3144361 ctcgtacaat taactctggt tcaaaaaata gacttccttg tgcagcgccg tcttcattca 3144421 tttttttcag caacattttc gcacaggctt cccccatttc aacaacaggc tgtctgaccg 3144481 tagtcaagcg cggcgaggag atgcgatcaa gaaacacacc gtcattcccg gtaaccgcaa 3144541 cgtcttctgg aattcgcttt ccaagggatt gcgccgcacg aatgacgccg agcgcgattc 3144601 gatcagatgc gcagacaaat gcggcctgat tgtccatgga tttcagcagt tctcttgcaa 3144661 ggcattcact tttcttagaa ctgttgtcga tccgaaacat attcgatttt ttaaagcttt 3144721 tattcatcgc ccgtatatac ccctgttctc ttgcacgttc gaaaggctca tctaaatcaa 3144781 tgccaaaaaa gacaacttcc cgctccccca gccccataac atggcgggtt gccataaaag 3144841 tgcctttctc gttattcaca tcgataaagt catagcccat ttcattttgt ccaaatacga 3144901 cgagcggctt ctcaaaagct tttattacac cttcaaaatc gttctttctc aagccggtgg 3144961 caataatgcc gtcacattgg ccaatattaa gagaatttct tgtcacaagc tggagagcat 3145021 agtgattgcg atccagctcc ctgctgattc ctgtcagcag gttcatgtaa tatggttctg 3145081 tcgtatccat ttcctcaagt atcaatagtt tcacaacctg tgttctgttt tgcacgagcg 3145141 ctctcgccgc ataattaggg atgtaattca gctctttcat cgcagaatga acaagctttt 3145201 tcaattcatc cgtcaccgtc tcagggtgat tgatcactcg tgataccgtc attttcgaaa 3145261 catttgcttt tttcgccaca tctgacaatg ttgccatttt catcccctcc ttatctgtgc 3145321 ttattatcca aactagtgat aaagtcctct attactgcta aatatacgat gcaggccaaa 3145381 gagaaataaa aaagagattt cccttaagga aacctcactt tgttaaaaac actcgatttt 3145441 tcatggattc atacgctagg tggcagactc attctctcca cttccatcag aaaatctctt 3145501 ttttaaattt ctgtccactt tttttctaaa atcggataag aataattttg catttgctca 3145561 attaactcat ccggccgtga cgagctgtga atcagtttta ggtgcgattc gttagaaaac 3145621 ccttcttgaa tgctgtattt caccattttc atcattggtt caaaatatcc gtttacattg 3145681 tacagtccaa ttggcttttg gtggatgccg atctgtgccc agcacagcac ttcaaataat 3145741 tcttcatatg taccgaagcc gcccggcatc gagataaagc cgtccgccag ctcgctcatt 3145801 ttagcctttc gttcatgcat cccgtttact tcaatcagct cagtcagatt ctgatggaca 3145861 acctccccgc tgaacaaacc gctcggcatg accccgattg cagttccgcc gttttccata 3145921 atcgcgtcag caatcgtgcc catcaagcct acgcgggagc ccccatagac aaggccgatt 3145981 ccctgctcag ccatatacac gccaagctct gccgcttttc ttttatacgc ttcatttccc 3146041 ccagggtttg atcccgcaaa tacacaaatg gttttcatct tgtcatctcc gcatctatat 3146101 atcgtgttaa acattcaaaa acacactata tattgtccca tcttcatgtg ataatatcaa 3146161 tatgaaatac ataaagaatg caggagtgat gaggttgcag ctggctgatg cagaaaaatg 3146221 gatgaaagag ttttacgaaa aaagaggctg gacagaatac ggacctttta ttcgcgtcgg 3146281 ctttttaatg gaggaagccg gagaactggc ccgggctgtc agggcgtatg aaatcggcag 3146341 agaccggccg gatgagaaag aatcgtcacg cgctgagcaa aaacaagaat tgattgaaga 3146401 aatgggagat gtcatcggaa atatcgccat tcttgctgat atgtatggtg tctctttaga 3146461 agacgtcatg aaggcccacc aagaaaaact gacaaaacga tttgagcatg cataaaaaag 3146521 cggccgcgat ggccgctttt tttaacctgt gatttcatca tggtgatcaa agaaatgctg 3146581 ctttcctatt ttgtgaaaaa ggcctgtttt atgcagtagc tccttcggct gcgattgcaa 3146641 tcctacaatc atcagctttc cattgtggcg tttaattcga ttcataatgt tcccaagcac 3146701 cgcttcagct gacgtatcca tatagtgcac cttattcatg agcagaataa gggttttcgg 3146761 ttttttctgt acatgctcca gcaatgacga ttcaagggaa tcaattgatc cgaaaaacag 3146821 cggcccttct atggcataca tgctgacaga tggatcttct ctcttcgcca gaacaggatg 3146881 cgtttcctga ttgtggatgc gggtcgcttc gctcattctt ctgataaaga acacgaatgc 3146941 aagcagcaat ccggttgcca caccgatgat taagtcaaac agaaccgtaa gggcgaaggt 3147001 cgccgccaaa ataaaggaat cagcattttt cagtctcagc atgtttgcga cttccttgcg 3147061 ctcactcata ttccatgcga ccaccatgag aatcggtgcc atactggcga gcggcacatg 3147121 ggacgcataa ggcgcaaata caagcaggac aaggagaacg actacgccgt gaacgacgcc 3147181 ggaaactggg gaaaccgctc cgttttttat attggtcgcc gttctcgcaa tcgctcctgt 3147241 agccgggatt ccgccaaaca ggggcgctgc catattcgca atcccctggc cgacaagctc 3147301 cttgttgctg tcatgctttg agcccttcat gttatcagcg accattgcgg acaaaatcga 3147361 ctcaagtcct ccaagaagcg cgatgacaag cgcagccgga aacagcataa ccattttatc 3147421 caaagtaagc tcaggaaact gaaattccgg caaatggcgg gggatttctc cataagttga 3147481 cccgatcgtt gccatgcggt cagggaaaaa gacaaccgcg accactgtgg aaataagaag 3147541 cgccaacaaa gcgcccggca ctttaggcat caccttggcg gatacaagca aaatgacgag 3147601 cccgatcaca gctgtcaaaa tggcatacac gttaaaggtg ccgagctgct gcacaatttc 3147661 aaacatgttg tgatgaaagt tctcatgttt ttcaacattt ctcaatccga gaaaattagc 3147721 gatttgttcc gtaaagatca gcacggcaat tccggctgta aaaccgacga taacgggttt 3147781 gggcacgaat ttcattattt ttccgagctt aaacagccca aacagtacca gcatcactcc 3147841 tgccataaac cccgcaatca gcagattttc caagccgtac tgcatgataa tgccgaataa 3147901 aatcgggaca aaggcgcccg tcggaccgcc aatctgatat tttgatcctc caaacaaaga 3147961 aatacaaatc cctgctataa caacagtgta tagcccatat tcaggctcga ctcccgaggc 3148021 aatggcaaac gccattccta aaggaattgc cacgacacct actacgatac ctgcaatcaa 3148081 gtctttctga aatttctgca aattgtatcc cttgaatctc cctgagaatc gcatattttg 3148141 ttataacctc ccttatgagt gattgtttat aagctcagtt tcataaccgt taatgaccac 3148201 atcaagtttt cctgtttcag ggtgaatgac aagcccgtga accggcactt ttttcggaag 3148261 cagcggatgg ttcttaatca tgttcacact gtgggaaacg ctttcttcca cgctgtgaaa 3148321 accagtcagc cacgttttca aatcgagtcc ggcactcgtc agcaaattca ggcagctatc 3148381 ctccaccccg cgttcctttg ctttctcaag aatcgaggac gcattcagcc ctgacattcc 3148441 gcattcatga tggccgacaa tgcatacctc ttcagcctgc aattcataaa tcgcgaccag 3148501 tatgcttcgc atcacgcttc caaatgggtg agaaacgatg gctcccgcgt tttttacaat 3148561 tttagcatca ccgtttttaa gccccattgc ttgcggaaga agttctgtaa gccttgtatc 3148621 catacaggtg acaatgacga gctttttcga aggaaacttt gtcgttttgt acggttcata 3148681 cttcttctca ctgacaaacc gctgattgtg ttccaaaatt gatgttaaag aaaccatttg 3148741 attcatctcc catccatatg attttgcaag ccttcttacc cagcttacag taaggaatta 3148801 tagcatagga ataagccaag aaaaggtttt caaaaaaaga cactataatt ggactgtaga 3148861 atcaaaacat aaacatttat atctttcaaa gataataaaa tttatattta atgcatccta 3148921 taatccggct gcagttcgta tatcgatgat ttgtctgaca aaaaatatgg gtgaattctg 3148981 ataattaaaa aactttttta agcagattta gctgttcgat cttcatttta agttcaaaag 3149041 aaccagaaat taaaaaaacg cagctatatt tttaacatct atttattttc gatataatga 3149101 attagacaac agccataaag ggggagcctt gttgaaacca tttgtattta tcacaaaacc 3149161 gattcctgaa gagattgaag cattcatcgg tgaacattgc cgttatgaag tatggcagga 3149221 ggatacgctt ccgagtgacg tgctatttga aaaattaaaa gaagcggagg ggcttttaac 3149281 atcagggacg tccggaccgt caatcaatcg tgagttgctg gaacacgcgc ctaagctcaa 3149341 agtggtcagc aaccaatcag taggctacga taacttcgat atagaagcaa tgaaagaaag 3149401 aggagtcgtc gggactcata caccttatac actggatgac acagttgcag atctggcttt 3149461 ttcactgatt ctgtcttccg ccagacgtgt tgccgaactg gaccgttttg tcagagcagg 3149521 aaaatgggga accgtggaag aggaagcgct tttcggaatt gatgttcatc atcaaacgtt 3149581 aggcattatc ggcatgggca gaattggaga acaagcagcg agacgcgcca aatttggttt 3149641 tgatatggaa gtgctttatc ataaccgaca tcgcaaacaa gaaacagaag acagcatcgg 3149701 cgttaagtat gcagagcttg atacattgct ggagcaatct gattttattc ttctcattac 3149761 gccgctgact gatgaaacct atcacatgat aggagaacgc gaatttaagt tgatgaagaa 3149821 ttcagcaatt ttcgtcaata tttcccgggg aaagacagtt gatgaaaaag cactgattcg 3149881 cgctcttcag gaaggctgga tcaggggagc cggcttagat gtatacgaaa aagagcctgt 3149941 cacccaagat aatccgctcc tgcagctgga taatgtcacg ctgcttcctc atatcggttc 3150001 agcaacagct aaagtgcgct tcaacatgtg caaacaggcc gccgaaaata tgctcgcagc 3150061 gatccaaggg caaacaccga aaaatcttac aagagaattt caataaatca aaaatccggt 3150121 ctgataacag accggatttc atattacata cgctgaagaa cagcacgctt ataaatatga 3150181 cgggtgacga tataataaag agcctggaat acaaaataaa tgaagatgac aattacggcc 3150241 tcaagaaata aattggaatt cagcatatta cttaacgctg catacgcaaa gcccgcgtga 3150301 atcgtacctg cgataaatgg gatgaagaat aaaaatccta tttgctttcc aaggatcgag 3150361 tgaatctctt tgtccgtaac ccctatcctc tttaacgcta acacctgcac tcccgtatct 3150421 tctatttccg taaacatccg caaatacagc atgcttcctt gcacgataaa aaacagcacg 3150481 ctgacaaaca gaccaataaa cagcattaat gcaactccct gcttcacaat ttgataacta 3150541 ggagcacgtg tttgaaaatc agatgtatgt tctttcggca ccatgttttc aagcttttca 3150601 gagacatcca ccgtctcctg ccaatgctca agctcataac ctaccattct catctgttcc 3150661 ttcagcggca catcctgtga cagactgtca aagctctttt cgctgacaac caataaacgg 3150721 ctgactccat cgacagacat caatatccct ttgttttgct gctttttcat gacataggaa 3150781 agggtttttc ctgacttcat atgaaatgct gctgtttccc cttctccaaa tgtgtctttc 3150841 accatcattt gaaaagaaac attaataaat gcttcatttt cttgtaaatg aataactggg 3150901 aacccttttt cctttgcgac ttgattatag actttttctg aaatcagcaa agcttcagct 3150961 tccatcttct tatttccata cggcaagtct gactgaaaag tgacaggaat ccctgtggca 3151021 tccaccttat acgtgataac agcatgagct tttttcaatg tattctcagc cgtctcaggc 3151081 ttcatgacct gaaagcggga agcatccttt tccacccagg aaacagactg aggaatgctt 3151141 tgctcctcct gcctttgtaa atcggaataa aacatataga tgacacctgt agctgttagt 3151201 atgaccgctg taatgacaga ggttaaaaac agcatgcgtg catgatcctt cagcctgaat 3151261 atcatgttgg aacgcacaat gatatttgtg cctttgtaga agctgtgttt ctttcggtac 3151321 agcatgcgga aaaatgccac actgctttgg gtaaaaaaga aatacgtgcc aattaacact 3151381 aaaatcaaaa ttggaaaaac ccgaaacatc atgtcaattg cattggctgt tgcagataga 3151441 taataaccgc tgccaagaca tagcaaagac aatacagtga gccatttcga ataaactggc 3151501 aaacttttcg gctttttggc tgatttaatc agttcaatga tttccagctt ccgaatccgt 3151561 cccagtgata aaatgagcag cgtctgaaac aggatgagaa agccggcaat tgtcatcaca 3151621 aacgctttcg gcacaatggc aaacgaaatc ggcaccttca cgctgagcat ccatgtcatg 3151681 atcataaaaa acagttttga aaataacagg cctgctccaa tgccggccgc aatcgccgca 3151741 agagaaataa gtgactgctc ataataaatc atcttgcgaa gctgctgctt tgatgtgcca 3151801 aacagtgtca gcagcccaaa ctctttcttt cttgcctgca aaaacgctga attggaatat 3151861 gtgatgaaaa atatacaaaa cacaatgatg acgacaagag ctgcgctcaa gcatgttttg 3151921 acaaggcttc ctccatatat attgtcttca ttgacatcag gatgaaaaat aaatgatgtg 3151981 aagacaaaaa acaccgaaac ggcaaacaca cagcttaaaa agtaggccac ataccgttgc 3152041 agattcccaa gaatgttttt acgggcgata gttctcaaat tcatgaaaat cgcctcccaa 3152101 cacactcaag gtatccaata tactttgata aaacacctgc ctgtttgttc ctctgtgaat 3152161 ctctgaaaag aaacgtccgt ctttaataaa aacaatccgt ttacagaaac ttgctgctgt 3152221 ggcatcatgc gtaaccaaca aaatcgtcgc ttccttttcc tcattcagct gagccagtgt 3152281 gttcatcact tgctttgccg attttgagtc gaggtttcct gtcggttcat cggcaagaat 3152341 gagcgccgga ttgtgaataa tcgctctggc acaagctgcc cgctgctgct gtccgcccga 3152401 cacctcatat gtgcggtgat cgagaatatg ctttatttgc agcgtatccg ccagttcatc 3152461 caatcgagct tccatttctc tcagctttac cttatccaat gcgagcggca agagaatatt 3152521 ttcacgaatc gtcagcgtat caagcagatt aaaatcctga aagacgaagc cgagttctct 3152581 tctgcgaaac aaagccagct cttggtcctt taacgttttc ggctgaatgc cgttgatcat 3152641 catctcgccc tgggtcggct tatcaatggt agccagcaaa ttcaaaagcg tggtttttcc 3152701 gcttcccgac ggccccataa tcccgacaaa ttctcctttt gacacactga gatcaaaggc 3152761 gctgagcgct tggtatgata ttgttccttt atttgaatag tatgttttcg ataggttcgt 3152821 tgtttgcaac acgttcatgt tctgctcctc ctttttcttt attataaaaa ggaagtcagc 3152881 atcctcccat cgaactttct tgcaattccg ctccccaatc ttacaatgct gtcacattca 3152941 cgagggtgtc acttgaaaac acgatggtca tcacagtgcc agccccttct tttgattccg 3153001 catacagctt atggccgaga cggctgcaca cctgttttgc taaataaagg cccattccag 3153061 ttgcctcttt catggttcgt ccgttttctc cggtaaaaaa cgcgtcaaaa atccgcggca 3153121 gatcctgcgg cggtatgccg attccttcgt cggcaaccga caagcgcgtc tcatgtccct 3153181 gtgtttcaat ccggattgta atagggtctc ccacaccttg ctttgaatat tttaaggcgt 3153241 tgaaaaggat ttgctcaaca acaaaggaaa gccacttttg atcactggaa atctgaacgg 3153301 catttggcgg cacatgtaat gttggaaaaa ggcgccgctt gataaactga cgtttttcct 3153361 gattgatcag tgaacgaacc atttctgcca aatcaaaggt ttgcggcttt acatcaaatg 3153421 caaattcctc cagccgggcc gtttgcagca tcatatcaag accgtggcga aatctctcat 3153481 tctcatcctc cagctcctct aaaaacgtcg gaaaagagga tgaggttccg ttttttcctt 3153541 cctgaatcat taaggatatg acagataccg gtgttttcat atggtggacc cattggttgg 3153601 tgaaggtgta atgctgtttt tgctgattga tatattgtga gagcctgctt tcgtattgct 3153661 gcccgagtgc gttgatcatc ttcgtccaaa gcgcttgctc tcctgttctt ggctttctgg 3153721 ctttcaaaga ctgtccgatg tcattcgaag aagaggcttg ttctgcaagc tttttaacat 3153781 atgtgagaaa ggaaaattgc cgaacataat cagcagcaaa acctgcggct aaaagagtac 3153841 cgggcaaaat ccatatgtac atcatatttt ctttggaagg ttctgcgccg ctctctacaa 3153901 tgcttaaata cgcaatcagc atggcggacc ctatccctaa taatgaaaat agaataatgg 3153961 ctaagcggtc gatgagataa gtctttaaca ttccgcttca tccttccgat tgacttgaaa 3154021 ttgataacct tgtcctctga ttgtggaaat gcaatctgtc agtcctgcat tctccagttt 3154081 tctccgcagc cgattgacat tgaccgttaa cgtattgtca tcgacaaaat caacgtcatc 3154141 ccataacgcc tccaatagtt catcacgaga gacaattttt ttatgctccc tcacaaaaat 3154201 cgagagaagc tggaattctt tttgggaaaa caaaatccgg acgctgttcc attcggcctc 3154261 attctgatca ggataaatcg tcagcccgcc aagctccact attctagatt cctgcggcaa 3154321 agagggcgaa tattcaccat atgtgcggcg caggacgctt ttgattttgg ccatcactac 3154381 ctctagatgg aacggctttg tgatataatc atcgccgcca ttttcaatcg ccattacctg 3154441 attcagctca tcggtccgtg ccgatataaa gataatcggc gcattggaaa tggtacggat 3154501 ttgcctgcac caataaaacc cgtcaaaaaa aggcaggttg atatcaagca gcacaagatc 3154561 aggcttcatt tctgcaaatt ccaattttat atcattcagc tgttcagcaa ttttcacttc 3154621 atatccgtat ttttgaagat gaccgcccag caaagaagca atccgctcat catcttccac 3154681 aagcaaaatc cgatacacgt tgatccccct tatatgtaca tcacgatgat ttttctagaa 3154741 gattccaaaa ttattatagc atgtgcggaa tagtaaatcg gtctttttct ttttgttatg 3154801 atagaatgat aaaggtaaaa ttttcataat aggcaggtgt cgtgatgaag aaaatcatgc 3154861 tgtttctggc aatgacgtca attctttcag catgtcagcc caactatacc gggaaataca 3154921 tagaaattgg ggatacacta actgactata ccaaagagtg ctttaaagag aatgaaattc 3154981 cttataaata cgaaaaggga aaactgtata tcccagaaga cgcatttgat acagcaatct 3155041 acacttgttc ataagaaaaa gcttgcagat aacctgcaag cttttcacgt tacaaaaaat 3155101 gagtatttaa tttctcttca aatcctgaag ggccgatgtc gcttttttga atgttaccgc 3155161 cgttttcata aatcgtaaaa tggcgctctg acatgaccat ccttccgctc ggcgtcagct 3155221 ttgaggcaag cagggatttg ttaaaaggag atttttcatg agagtgaatg atgtccttca 3155281 tgttatctaa atcaccgaga tcactctctt caagggtaaa ggcgtaccca atttgccagc 3155341 cttctccttt gtccatcagc agaacatagc tgcccttttc tgtctcttcc tttttgattc 3155401 ggaatgaccc gactggtgac tgtaccgttt ctccggaaag cggtatcggc tggagcgcca 3155461 ggttgatgcc gaagccgata tcaacgaggt aatcgccgtt ttccgcagac agccatacag 3155521 cagcatgcgt cccttctagt gcccatccct cttgatcgcc tgcataaacc gttcctcgaa 3155581 tgagcttcac atgaaacccg gcctcacgca agacaaaata aaggaaacca tttagatcgt 3155641 agcataggcc gccgtgctga tctttgagca gacgtcgcca tagctcttct tttgtgatct 3155701 tataattctc ttttgcaagt acggcacggt tttcgaatgg aaaacggtat gccattgctt 3155761 taagaaaaag gggaagatcg ccgaagctga catggtcttt ctcccagccg attttctgaa 3155821 agcagtcttt tagaaagtca ctcattttta tcacctaaac ttcttcttga acgtaagcag 3155881 ccagcttctc cagcgcctct tgttcatctt ctccctgggc aatcaaggta acctcagtgc 3155941 ctgtgcttac cgcaaggctc atcagcccca tgatgctttt ggcgtttact tttttcccat 3156001 ccttctcaag aaacacatct gacgtaaacc ggtttgcttc ttgtacaaac aaagcagcag 3156061 gacgtgcttg cagtcctgtc tttaatcgaa cttccacttt ctgttgaacc ataagatctc 3156121 cccttttctt tacggttatt ttaaagtgac ggtttgccct gtccgcagct gttctgcgat 3156181 ttcgtcaagt tttctcagcc tgtgattgat ccctgatttg ctgattttcc cgcttgctac 3156241 catttcccct agctctttca gcgtcacttc ctgataatca atccgcagct gcgcaatttc 3156301 ccgaagtttt tcaggcagcg cctccaggcc gattctttca tcgatgtatt taatattttc 3156361 cacctgtctc agcgatgcgc cgatcgtttt gtttaagttg gctgtttcac aattgacgag 3156421 gcggttgacc gaatttctca tgtcccgaac gattctgaca tcctcaaatc gcagaagcga 3156481 attgtgagcg ccaattacgt tcagaaactc tgtaatcttt tcagcctctt ttaaataggt 3156541 aatatagcct tttttccgtt caagcgtttt gctgtttaac tgaaactcat ttaacaggtc 3156601 acataatgaa tcgttatgct ccttataaag agagaagatt tctaaatgat acgaggaggt 3156661 ttccgggtta ttgaccgaac ctcctgccaa aaatgctcct ctcatataag aacgcttgca 3156721 gcatctcttt ttgaccagct ctttcgaaat acttcgttca aacacaaaat tctccccgag 3156781 tatttttaaa tcctctaaga tcgcttttgc attttctgaa aaacgcacaa tatagacgtt 3156841 attctttttc agccgcattt tctttctgac cagcagctcg accgacacat catattgttt 3156901 tttcagcaat gtatagatgc ggcgggcaat cgccgcgttt tcggtttgaa catcgagtac 3156961 gagatggcgg tttgtaaatg ataaagctcc attcatccga atgagtgcag acagctcggc 3157021 attaatgcag cagtccttca cttccagatt cgttaattct ttttttgttt ctgatgcaaa 3157081 tgacatatag ccacctcatt tcaaggcttc attctttcag taaatcaaca agaagagagg 3157141 ccactttatg tgtatcgtga cgtattacgt catttttata cgttacaatt tgatctctga 3157201 tgacttcaag ccccatcgct ttcagctctt cgatatcaaa atcaacagga cgcgccgatt 3157261 ccatttcgta cttacgtttt atttcgtcgg gaatgtcttc actgttcact aatatcgtat 3157321 caataaaacc acagcccata tgctgattga gcgctttcac atgatcagca gcggtgtaat 3157381 ggagcgtttc gccgggctga gtcatcacgt tgcaaatgta tacttttttc gccggcgcct 3157441 ttatcacttc ttccccgatt tttgggacga gcaaattggg aagaatgctg gtatagaggc 3157501 ttcccgggcc gataataatc aaatccgctt ccctgattac gtctattgtt tccggcagcg 3157561 gatcaatctg ttcaggcgtg agaaaaacac gcttaatgcg ctgtccgtat tctgggatcg 3157621 ttgactcgcc tgagaccacg cggccatctt ccatctcagc atgcaaaacg acactggcat 3157681 tggcagccgg caaaaccttt cctcttacat tcagcacctt gctcatttct gtgacagcgt 3157741 gaaaaaaatc accggttata tttgtcatcg ctgccaaaat caaattcccg agagaatggc 3157801 ctgttaagtc attcccttta ttgaagcggt gctgaaaaag atcttcaaca agcggctcca 3157861 catcggataa agcggcaagc acatttctga tgtctccggg aggcggaatt ttcagttcat 3157921 tccgcagacg gccagagctc cccccatcat cggcaactgt tacaatggcc gtgatgtcaa 3157981 cgggtttatg ctttaggccc cgaagcaata cagaaagacc tgtaccgccg ccaaagattg 3158041 cgattttcgg cttttgtccc atcttatttc cggcttctct tttcaatgtc ccggtgagta 3158101 acatgagtat agtaatcctt tttgaaataa tcagctaaat tctcggctaa tgtcacagag 3158161 cggtgctggc cccctgtgca gccgatcgca atgacaacct ggctttttcc ttctcttttg 3158221 taagatggaa gcataaagct cagcagatca attaatttct cattgaactt ttgcgtttca 3158281 ttccacttca tgacgtaaga ggaaacctct ttatccttgc cagtcagcgg ccgcatgctt 3158341 tcgatatagt acggattcgg caaaaatctg acatcaaaga cgagatctgc atcaattgga 3158401 ataccgtatt taaaaccaaa tgacatcaca tttacggtaa atgtctctcc ttggtttgtc 3158461 gcaaagtgct tcacgatttt ttcacgcaaa tcacgcggct tcatgtcaga cgtatcgtaa 3158521 atgatttgag agcggccttt taattcctca agcagctctc gttctagcgc gatgccttca 3158581 agcggcaggc cagtcgctgc cagcggatgc gagcgtctcg tttctttata tcttgtgacg 3158641 agaatggaat ccttcgcgtc caggaataaa attcgcggtg tgatccacgg attttcggcc 3158701 atttcatcca gcgcttcaat cagccggtca aaaaattcgc ggccgcgcaa atccatcacg 3158761 agcgcaactt tgctcatttt cgaatttgat tccttcatca gctctaaaaa cttcggaagc 3158821 aatgaaggcg gaagattatc gacgcagaaa tagccgagat cttcaaagct ttggatcgcg 3158881 acagttttcc ccgctcccga cattccagtt ataatgacaa gctgaatatc atgtgattca 3158941 ctaacactca tctttctccc ccctgacttg tctttctatt tgatgtgctg cgggtctaaa 3159001 cgataactga gcagctcaaa ttccggtgta tacgtaaatg tgccgtgcag cagcccttgt 3159061 cccttcatca taaaatcaag gatatggccg tctccagggg ccataggcag gttctgaatg 3159121 tcattgacat cgtgccactg cagtttgcct tcctctgatt ctgatacatt ttgtcctgta 3159181 tatgaatcag cgacaaacgt aaacatcatc cactcggaga caatgtggtc accgtcttta 3159241 ataataaagg taaaaacgcc ttttaattga ggatttatga tatagatacc agtctcttct 3159301 ctgtactctc tgatgacgga gtctctgact gattctccgc tctccatctt gcctcccggc 3159361 gcgacccacc atccgcgtct cggcttttga agcagaagaa ctttgtcatc cgtctgaagc 3159421 acacaatttg tcactctttg caagtacgtc acctaacctt cgtcctgtca tcgtctcttt 3159481 attataccgc ttcaagatgc ctcccacaat gaagagacat tgacaatctt ttcttctatt 3159541 ttacagcata ttcattcctt aattcagatg attttgctgt aactggaatt ctcttttatt 3159601 tatggacaaa aaaaggacac ggataactgg agaatccgtg ccaaaaaagt gtattcatta 3159661 taaaaagggg gtcaattact ttattaatca taaccgaaaa gcattacaca tgtgttacag 3159721 cggaattaaa acccagtaac gtaatgtgaa actcgtatga cagccctttt tattttaagg 3159781 ttttcagcgt ttcttggagc tcttcgacat aatgttgtac gctttgtgcc gcaatgcttc 3159841 cgtctcctgt agccgttacg atttggcgca gtgatttttc gcggatgtct ccggcagcga 3159901 aaatcccttc aaccttagtt tccatgcggt cgtttgtttc gatatagcct tcttcattcg 3159961 taatgcccag gttttcaaac ggtttagaca gaggaagcat gccgatgtaa atgaatacgc 3160021 cgtctgtttt gaattcactt tcttcaccgg ttaccgtatc gacaagcgtt acgttaccga 3160081 ctttgccgtt ttcctcatga atttccttca cagttttgtt ccataggaag tcaacttttt 3160141 cattatcaaa tgctctcgct tgaagaatac tttgagcacg gagtttatca cgtctgtgaa 3160201 caatcgttac ttttgaagcg aaacgagtca gatatacgcc ttcttcaacc gcggaatctc 3160261 cgccgccaac aacgacaagt tctttgcctt taaagaaagc gccgtcacat actgcacaat 3160321 aagatacacc gcgtccgccc aattcttttt cgccaggcac gccgattttt ttatattccg 3160381 cacctgcagc aatgatgaca gcacgggctt tatattcctt tgaaccagct ttgactactt 3160441 tgtactcttt gccgtcaatg acctctttaa tatcgccata agcgtattca gcgccgaatt 3160501 ttttcgcgtg ttcaaacatt ttgttagaaa gctcaggccc aaggatactt tcgaatccag 3160561 gatagttttc tacatcttcc gtattggcca tttgtccgcc aggaattcct ctttcaatca 3160621 ttaatgtcga taaattcgct cttgatgtgt atacagcggc cgtcatccca gcagggcccg 3160681 cgccgattat aatcacgtca taaatttttt cttctgacac actattcact ccttaaacca 3160741 tcttttcaag tttgggctct ttcttataag ataagaatcc ccatcaaacg tattccttac 3160801 ccatatccta taaaatctca tggtgatacg ctattttttt gctcaacacg attaaatgta 3160861 ttcgaaaagg gtatatgtta ataaagaaag agccttctgt ttatagaagg cccttgtcat 3160921 atttattatt gaacaacacg tcttacaaca cctttaaatg ctgctttcca gtaaggattg 3160981 ctcatagagt caacagatac gccatgagat gtattgtcgt ttaggaaagt accgtttcct 3161041 aagtagattc ctacgtgtcc atttgttttg taagtgtcaa agaacacaag gtctccgcgt 3161101 ttcatttcag acgcgctgac agcttgtcct ctgccaacta acgtatcagt tgttgttccg 3161161 cctacaggtc caaggttaac acctgcagaa gcgtatgccc agcgtacgaa tgatgagcag 3161221 tcaaaaatac ggttgttgat atcagactga gtgcgtccgc cgccaaactt gtacggagat 3161281 tgtcctacaa tgcttgaacc aacgctgatc gcgccttcaa ttccgccaga gttgctgata 3161341 acagtgccgc ctgaattgct gtttgagccg ctgctcttct tagaagatga gccgtttgac 3161401 gaactgtttg atgaaccgtt agaagaattg tctgaagaat tgtctgaaga atcatcagat 3161461 gagcttgctt ttgatgattc agttgtcgcc gtttgactgt catctgtttg tgtttcatca 3161521 gatgcttttt gtgcttcttc ctgctttttg atcaaagcag ccgctgcttc ttgttctttt 3161581 ttgatgcgtg cttgttcagc ttcagtattt gctttttgat ttgcaagttc agacgcctct 3161641 gattttaatt cagaaatcgc tttagccgtt ttcttttggc ttgcttttgc ttcgtcgaaa 3161701 agcttgtctt tttcattaag ctgtttatca aggtcttttt gcattgtttc taatttagcc 3161761 aaggcagctt gaacttcttt cagcttgtca ttcaaatccg cttcagaatc ttcgagcttc 3161821 gctttatcct gctcttgctg tttgattaaa tctttgtctg cgtccacaat agatgaaacc 3161881 gcagtcgcac gagagataaa gtcaccaaag cttgttgatc ctaaaagaac atctatgtat 3161941 ccttgagatc cgccgctttc ctgtaaagaa cgaacgcgtt ttttcaggat ttcattgcgt 3162001 ttttcgatgc gtgcttcagt ttctttaatc tcttttttca gttttttgat ttcttctttt 3162061 gttttatcgt tttcttcttt tttatcttca atcttgttgc ttgtatcaag cgccttatcg 3162121 ttaatgtctt tcagttcttt ttcaatcttt gattgatttt cctgaagctc ggttaattct 3162181 ttttccttcg cttcaatgct ggaagcaacc tcagattgct tgctttcgat tttttgtttc 3162241 ttttcatcta atgtttccgc cgatgcagtt ttacttgtaa atgggatcaa aaaactgctt 3162301 gtcccgatga cggaagccaa accaagtgta attaaactct ttctcacttt ttatatcctc 3162361 ccttttactg tgaacctgtc ctcatttgga atcgtatttt gaacatcaag tttcgttcct 3162421 catactctac gaggaatgat ggttgtttat ggttaattat tctgtgcatc tcttattctg 3162481 gttgtatagc gtttatttca catcatatgt aaaaaacact aattccttat gtacgagaat 3162541 cattatacca tcaagtttcg acaaattagc gataaatttt attacattta tgtttcaaac 3162601 agatgtcaag tcacacatca tttgtcattt ttcttaagcg tgtaaaaaaa ctgtcgatat 3162661 tattttctta atataatcta tctaacaaaa aaagagtcga ttaaataaat caactcttta 3162721 aaatttacta ttctagaata tcatcaatat atttcatata tttcgtcaaa gttgccggag 3162781 agatgccgaa tcgggccgct gtgtcttttt tcgtgtcttg cttgccatgg gcttctttcc 3162841 aaatataaca gatggctgct gcccagcctt tctcattctt caacggagca gctgcacgaa 3162901 tttgctggat gacatgaaaa acccagcagc tcatgacttc tgttttcatc tcttcttttt 3162961 cagcttgctc taatagtttg accgtttgat aagcgaaaag tgcatcctct gaaacgtcag 3163021 cagccgcaga atctccattc agaagcagct ttacaaaatg agtttcaaaa ggagcggtaa 3163081 ttctctttga gcgtatcacc gcttcaagat gctctgtttc tccctttgtg ctgctgatat 3163141 aataggctgc gagtcgctgc tccacagatg aaggaagagc ttccctccgc tcaatccaag 3163201 gcgccgggcg gtcttcgccg ggatattgcg actcgacttt tctccagatc gtctcggcaa 3163261 agtcggtatg tcccgtaaaa taagcagagc aggaaagcca gtaaaagaag gtgtcgtcac 3163321 cctcaaagcc ggttttatat aatgatttga gccatttata tccgatctcg tagcggccga 3163381 caagcgccaa agtagcaccc aatttataac gctgctccaa tagcatcgga tagacattgg 3163441 agagctgatc actcaattcc gccacttttt cgtcttctct ttcataatag tagaaaacga 3163501 gaagattgca taaggcgtga agatttcctt cattatgaga aagcacttca taagcggttt 3163561 gcttcgcttt tacaacgttt cctgaataga aataggcaag cgcgagattg ttgtatgctg 3163621 accaaagctc cggatattca gttgtgattt cctcaagcgc cgcaaccgct tcagcaagct 3163681 ggccgctttc cagcaatgac tttgcccgat cctgtttcac cagcagttca tcctgatcat 3163741 acaacgaatc ctcaatgccg tcgtctccta aatcgagcaa atcaagcaga ctatcgtttt 3163801 cttcggcgaa ttcaccatcc gggtccgcat cagaataagc ggccgcttct ttataagctt 3163861 cctggaagag ccccagatgg gcaaagttat tcgctttaaa gtaatggcac tccggcattt 3163921 cggcctccag atttgccatg atatagtcaa gaagatcgtt cgactcttga tactggccca 3163981 tttccgaata aatgaccgca agctgtgaaa gcatctctga atcctccggc tccaaatgaa 3164041 ccgcgcgctg aatcagtttg cttgcccgtt ttagattgcg ctctttatac gctttcaagc 3164101 ctttatgaaa aaaatattgt ccatcttgaa gcagctggac aatttgtgcg tgatttttat 3164161 gttcagaagt gtgttttccc acaactaccc tccgttttat acaatattac cgtcagtagt 3164221 ataccataaa tcgtaagccc ctcaatagtt caaaaggaag gattgggaaa atccctcctc 3164281 ttttttattg gctgattcga ccaaaattta cccggctttg ttttctaagt ccgcattcat 3164341 tttcagctgc tgttcagcaa aatcccggta aaggccatgg gaagccatta actcatggtg 3164401 tgttccacga ccggtaattt cccctttttc aacaaacaaa agctggtccg catctacaac 3164461 ggtagatagg cggtgagcga taacaatcgt tgtgcggccc tccatcagca cctccagcgc 3164521 ctgctgaact gatttttcag attggctgtc gagacttgag gtagcttcat cgagcataag 3164581 aatgcttggg ttacggagaa gcgctctcgc aatcgcgatt ctttgccttt gtccgcctga 3164641 cagcataatg ccgcgttcgc ccacttctgt atcaaactga ttcggcagct cctttataaa 3164701 attgagcgca tatgccatct ccgcggcttt ttcgatctca gcatccgtca catctcgttc 3164761 taacccgtag caaatatttt ctctgattgt cccggacatt aacgggcttt cctgtgatac 3164821 atacccgata tgctccctcc acgattcaag cgagtaagta tcgaccggct cgtcccccag 3164881 ccgaatggtc cctgcagtcg gagaataaaa gcgttcaagc agcttaaaca gcgtcgtttt 3164941 tcccccgccg ctcggaccga cgatcgctgt cactttccct gcttcaatga cggcgctgac 3165001 ctcttttaag atcagctgat caggcttata tccaaaagac acgcgatcaa gctggatagg 3165061 cagatgtgca ttttcaattt gttttcctgt cactgtatct tcctcttcct ctgccaaaat 3165121 ctcaatcatt cgttctgttg caccgattga tttttgcagc tgtgtgaaaa acgttgtaat 3165181 ctggcccatc ggcataataa tttgaaacaa atataaaata aaagccacga gcgctccggc 3165241 tgtgagctcg cctgatgaga cctgcatgcc gccatatccg atcactgcga caagcgctgc 3165301 cattaacacg agtgaaataa gcgggccgac aagcgattga accttggctt cacgaacgcc 3165361 aagcttaaat aatgaggaaa tccccatctt cccgcgccca tattcgacat cctccgcatt 3165421 tgaagcctta acaagtctga tttccgggag aatttgatta agcaggcctg taaaacgagc 3165481 cgtttcatct tgcgtttccc gtgaaatgga gaacattttc cgtccaatcg gcaccaaaat 3165541 aagagcggcc agcggaacga ccactaacac aagcagtgtc agcttccagt tcataataaa 3165601 caagattgtc aatgatccaa tgacagaaat gatgcctgta ataaatccgc tgatatgggt 3165661 tgtaatcaat tctttgacca ccatcgtatc gttcgttaca cggctgactg tttctccgga 3165721 agcatttgta tcgaaataag agacaggcag cttaattaat ttcttccata ataactcccg 3165781 cagcccggaa atgatttttt gtccattata gttaagcgca taggtggcat aagcgcttaa 3165841 acccgcctga acgaaaaaca ccagcgcgat caaaccgatt tgcgtgcctg acagatttga 3165901 catagaaaaa ccatcgacaa gctgcttcgt taataatgga atgagcaggc tgaccagcgt 3165961 ggttactaca ctgagggcaa gcgcaaaggc gagctttcca taagaaggat tggtccgtct 3166021 tactaaggca aaaaagggtt tcaatttact tttagatttt tgtttcttgg ttggcatata 3166081 ttttcctcct gtttcagcgt tcagaaaggt gaaaagtcat agcaaaagga tgatttttac 3166141 tctttctcaa tcatatcaat ggagaaagac tttttcagta tatttttgcc gtgatcaaaa 3166201 taaaaatctc ccactcattg tttgaatagg agatttttgt gttagacatc tttcactggc 3166261 ttcttttttc tgtaagtcaa tgttacatcc tgctgtcgca ggtcttctat tatcattttg 3166321 taccgatcaa cttttgcggt atgttcttct tttatcatct gaagggcagc ttttcgtttt 3166381 tcgctattag actcaagctc tttttttatt ttttttacaa tcaacccttt ttgccctttg 3166441 atttcctctt ttaatgaaga ctcaaatttc tttgtcaggc tgagaaagtc gttgatcggt 3166501 tgattgaggg tgcccgcttt ccccttcatt tcatcttggg taagaaacat ataggtcgtt 3166561 gatacaattt ctgtttcact ttctgaaaat aaggaagtca ctcttcatat tcctcctaag 3166621 actgaaaatc aaataactga gaaatcattt cttctttttc aaacagcttt tcaatactct 3166681 cgcggatatt tttgataaaa tctctttttt ctgttgtctg tttttttaat tcagcaacaa 3166741 ttccatcatt tgcaggaagc gcacctgtgt ggaatgattc atgaactgag attttctcca 3166801 atttatcgaa tgtgtggctg aaaccagctg caagccggaa ttgaagatcg aaggcataat 3166861 gcgaagggtt ttcttccata tgatgaatag ccgtgatgat cgcctgcttt ttgtctatga 3166921 agtcttcatc gatttcctga ctgtaaacct tctggtactt agaaatcgca tcttccatat 3166981 cttcaacgat tttcataccg ttttgataga ttctgacagc ggatgagaga ttgacttgaa 3167041 tcgtttctcc cgagccactc ttccctgtaa aataaatatc ggagccttta tagctgaagc 3167101 ctttttcctt tgacaaggcg ttgagcattt gaacgatgct gtggccgtcg acgataagtt 3167161 ttagtgcgtc ttttgtttct gtgtcgagtg ttttcaatga ggacagaatt gattttacat 3167221 agtccactat ttcaccaacg tcttttaaag cttgcataaa ttggccatgt tttagatggt 3167281 ctatgaaatg ttcgtaccgt gactctatgc ctcgcatact cgcattaata ttcgttaatt 3167341 cttttttgat gactttcttt tgcgtttcat caatataacc attttcagct aactgatcta 3167401 cgaccggtcc gctgtttctc aacaaggtat gaagaaaacc taaaaacgac ggcagttcct 3167461 cttttattcg gccatacatt tgcttaacat catcaaaatg ctcatatagg acacttactt 3167521 tctttaaagc gccgtctgtg tttttcactt tttcaatcag gtctatgtct atcccgctgg 3167581 ctgcctttat aaaaccgttc aagccgtctt tttcatagtc atccttatat ttttgaagga 3167641 atttttgaat tgacctcaca tcttcgtcag gaaccccatc cataatgttt cggatgcctt 3167701 ttacacttgt atttgtatct gccatcttca catcaccgaa tgtaataaaa tcggccttgc 3167761 cgctgactcc atacagcggg tcatcttttg agatgcgctg agtgatgttt gttgttacgc 3167821 ctttgtcttc ataatatttt tggatttctt tttttaactt ttctggcggg atggaatcta 3167881 tatcttcata tttataacta aatttcctaa taacatatct atataaactt tcatcagttt 3167941 caagtaattg atcaatattg acttgagctc catttacccc ataaacttca tcatattctc 3168001 catcaatcaa ttgcaccata acttggttat tatttgcaag tgaatgtcct aaggcgaatg 3168061 tttttaaatc ctcagagtta cctgctgctt tctttgcttt gttagtaaac tcctttgtag 3168121 cctcatactg actatgatca attcctaaaa aaagaccaaa aaagttatat gaccaatcct 3168181 tattatcggc actaccttct gaaataatct gaagctgatc aatatgtttt ttctcatcta 3168241 ttatatggat tgccgttcca tcgtaacctg attctctggt cgaactttgt atacttgtat 3168301 tctgatttac aagttcattg gaggtgtaaa tttcaatttt catattctca ggaagatcgt 3168361 ggtgggtttc ctctttataa attctgcgta tatctgcttc gaaatccttc ttagctttct 3168421 taacttcact cgcaatagtt gaggcaaact tttgtttata gtcatattct aaatcaatta 3168481 accttaactt tacgttctca ttctcaaata catttttatt tcccatctta tttctccttt 3168541 ttatctatta aaaaggtgat agaattaatt aatttctcaa ctttattttt agccttttct 3168601 tcatctaagg agcatggttg attttcattt ttgcatccaa gggtaaaggc gtattctact 3168661 cctaggttat cttcctctgt agacttaaca tatccaaaat aactgtatga ataattatat 3168721 tttctatcaa tatcgtcaaa gatgtctttt ttcttggcag tgtaaatatc cgttttcttt 3168781 ttgctgcttt ttttgtattc gcctttataa tcattttttc cactaacaat atctagcatt 3168841 gtcttaggtt cattcgcaaa actttcttct ttgtaatatg ttacatggcc atcaaacatt 3168901 acattggtgt ctttatcata actattaaat ccaatacttt ctttgttttt cccggttaac 3168961 gatgatcttc ttgatagata ctttccatcc tccggaaaca acatcctaaa ccctttcagc 3169021 ttagattcca gcaaataata tcctggttcc tcttcttttg ttgacaccat gtactctctc 3169081 gttttctcgt cctgaaacgc aggtacttga ggcagatcct tgggatccat gtcttttggt 3169141 tttaccgctt ctgttttatt gtcatttgtg ctgtttttat cattgtcatt catactgcat 3169201 cctcctgtca gggcaagtaa taagctgaag caaataaaga tgatcttttt cattacgaac 3169261 ctccacgggt tttgtgagaa tagtattcta tttttatatc aaaaataatt ctattgacct 3169321 ggttaagaga tgattatttc atcctttttc atgttacatc atggcggaat ttggataaat 3169381 aggaaatgag actcggtttt gatctccttt tattaactaa tcatatataa cacccaatat 3169441 aaatctaaat acctattact tttttcacaa aacaaaaaga gccgtatcat ccggctcttt 3169501 actcttcaat ctcagaatgg cgttttttca atacgtcaag cacatcatcc agcggcaggg 3169561 attgttctct gagcaggaca agcaggtgat acagcaggtc tgccgcttcc catttgagtt 3169621 cctcatgatc ccggtttttc gcggcgatga tgacttcgga tgcttcttct ccgacttttt 3169681 tcaaaatctt atcgacgcct tcacggaaga ggtacgtggt gtaagctcct tcaggcattt 3169741 ccgcttggcg ttccgcgatc acccgctcca gttcgttcat gatgccgaat cggtccgcgg 3169801 cctgttcttc tgtttgttcc tttgtaaaac agctgtagct gccagtgtgg catgccgggc 3169861 ctgacggttc tacgagtacg agcagcgcgt cttgatcgca gtcataccgg atacctttga 3169921 cggcttgcgt gttccctgag gtttctcctt tatgccataa cgcttggcgt gagcggctgt 3169981 aaaaccatgt ttccttcgtt tccagcgttt tttcgtacga ttccttgttc atatacgcaa 3170041 gtgtcagcac ttctttgctt gccgcatcct gcacgatagc aggaattaat ccgtcctcgt 3170101 taaaacgcag ttcatctgcc tgtttcatct cacattcacc ccgtactctt tcaagtatga 3170161 tttcacttct ttaatcgatg tttctttata atgaaaaatt gaggcggcca gcgcggcgtc 3170221 ggcttctcct tttgtaaaag cctcaagcat atgctgtgcg tttcccgcgc ctcccgaagc 3170281 gataacaggg acggggacag cttcggaaac aagctttgtc agcgtgtggt cgaaaccttt 3170341 tttctcaccg tcggagtcca tgcttgtcag caatatttct cctgccccgc gtttgacgcc 3170401 ttcttttgcc cacgcggtga cctcccaatc tgttttcttt ctgccgccgt gcgtgtagac 3170461 cttatatgtg tcagattctt tgtcatactt ggcatcaatg gcaagtacga tgcattgaga 3170521 accgaaaaac tcggctcctt ctgtaatcag ctcagggcgg agaacagctg ccgtgttcac 3170581 cgacactttg tccgctccgg cacgcagtat cgttttcata tcgctgagct gattgatgcc 3170641 gccgccgact gtaaacggaa tggcaagctt cgcggcaacc tgctccacaa cgtcaaccat 3170701 cgtctttcgt ccttcgtgcg aggcggagat atcaagaaaa acaagttcat ccgcaccttc 3170761 ccggtcgtac acttcggcga gttcaactgg gtcaccggca tccttcaatt cgagaaattg 3170821 aattcctttg acaacgcgtc cttctttgac atcaaggcat gggataatcc gttttgtgat 3170881 catttgcgct tcaccctttc aagcgcctca ctcagcgtaa actgattggt atacagcgct 3170941 tttccgatga tcgctccaga gacgccgtcc gcctcattgc gggcgagagc ttcgagatcc 3171001 gcgacggagc tgactccgcc ggaagcgatc accgatttcc ccgtttcctt agcaagctcg 3171061 accgtgcttt taacattggg gcctgacagc attccatctg tcgcgatgtc agtaaaaata 3171121 aagacttccg caccttcatt ggctagctct ttgcccagtt cagttgcctt aagggttgat 3171181 gtttcaagcc atccctctgt tgaaacaaaa ccgtttctcg catccagtcc gattgcaatt 3171241 ttctcgccat attgtttcag catttttttg acaaacggag ggttagaaac tgctgagctt 3171301 cccaggatca cccgctcgac tcctgctgat aaatattcat agacgtcatt ttcagaacgg 3171361 atcccaccgc cgatttcgac tttcaggttc agcttttgcg caatctcaat cacatggcgg 3171421 tcattcactc ttttcccttc tttggccccg tcgagatcaa cgagatggat ccattcggca 3171481 ccctctttct caaataactc agccatgtcg tacggtgaat cgccatatat cgtttcctta 3171541 ttataatccc cttgaacaag gcgaacacat ttgccgtttc tcatatcaat tgccggatat 3171601 aatgtaaaag cactcatttt ttcaccttct gttctgctgc cattttcgta aattgggtta 3171661 aaatagacat tccgaccgtg ctgctttttt ccggatgaaa ttgggcgccg aagacgtttc 3171721 tttttccgac tacagcaggc actcgtacac cataatcggc gcttgccaga agcgcgttct 3171781 cctccatccc gtcaatgtaa taggaatgaa cgaagtaagc gtagccttgt tctgttttag 3171841 tcagcagcgg agattcatta tgaaaagaaa gacgattcca gcccatatgc ggaaccttca 3171901 gcttgtttcc tttttcatct tctgctttca gcctgactgc ttttcctttt aacagcccga 3171961 gtcctgaagc ggtgccgttt tcttcgcttt cttcaaataa aagctgcatg ccgaggcaga 3172021 tcccgagaag cagccttccc tctgagacca tatcgtgaat caattgatca agcttcgtgt 3172081 agcccaaatt gtccatcgcg tctccaaatg aaccgactcc cggcaaaatg aaagcatcag 3172141 cttctttcag ctcctccggc ttttcagaaa caaaatacgg cacgccgaca cgttcaagcg 3172201 cctttgagac actgtataaa ttccccattc cgtaatctat cacgccgatc atttacagca 3172261 tccctttcgt tgacggtatt cctttaactc gcggatcgat cgttgtcgct tcatcaagcg 3172321 cacgtcccag tgctttaaaa acggcttcaa tcatgtggtg ggtatttgtt ccataatgaa 3172381 cgatgacgtg caggttcatt cgagcttcga gcgccagctt ccacaaaaat tcatgtacaa 3172441 gctccgtatc gaaagttccg actttagcag ccgggaaatc agcgcgcatt tctaagtgcg 3172501 gccggttgct taaatcaatc acaacttgag caagtgcctc atccatcggc acaaacgccg 3172561 atccgtagcg tttgattcct tttttatcgc ccaacgcttc gagcagcgcc tgccctaagc 3172621 agatgccgat atcttcagtc gtgtggtgat catctatatc aacatcgcct tttgcgttaa 3172681 tggaaagatc aaattggccg tgtttcgtga ataaatccaa catatgtgtc ataaacggca 3172741 catctgtttt aatatccgct tgtcctccgc cgtctattgt aaatgccagc tcaatatctg 3172801 tttcgtttgt tttcctgacg cgttccgctt ttctcattta gaaatcctcc gttctctcgc 3172861 ttcaattgat ctggcatggg cttctaaccc ttccagtctg gcaaaagccg cgatgctttc 3172921 ggcatgttct tcaaaggctg attgactgta agaaataatg ctcgatttct tttgaaaatc 3172981 agttacgttt aatggacttg aaaatctggc tgttccgttt gtcggaagca catggttcgg 3173041 tccggcaaaa taatcaccga caggctcagg gctgtatctg cctaagaaaa ttgcacccgc 3173101 atgtttgata ctgccaagca aagcttccgg agactgtgtt atgatttcta aatgctctgg 3173161 cgcgagtgta ttgacagtct caatcgcttc taccattgtt tccgccacat atatacaacc 3173221 gtaatctctc actgaagctt ccgctatttc tcttcgcggc aaggtttcca gctgcttatt 3173281 cacctcggct gaaaccgtct cggccagcgc catggaatct gtgacaaaca cacatgagct 3173341 aagcttatcg tgttccgcct gtgacagcag atcggctgca atttcgctcg gaatcgctgt 3173401 ttcatcagcc agcacgacga tttcactcgg tccggcaatc atatcgatat cgacatcgcc 3173461 gaacacttct cgtttggcaa gcgcgacata aatgttgccc ggacccgtga ttttatccac 3173521 cggctcaatg gtttctgttc cgtatgctaa cgccgcaatc gcctgagcgc cgcccatttt 3173581 gtaaatgtct tttatgccca gctcggctgc agcaaccaaa actccaggag acagcagacc 3173641 gtcttttccc ggaggcgtga cgagaacgat tctttcaacg cccgctacga gcgccggaat 3173701 cacattcatc aaaacagatg aaggatatgc ggccgttccc cccggcacat atacaccggc 3173761 ggaatccagc gccgtcactt tctgccccag cattgtgccg tcctttctgt gataaaacca 3173821 ggaggattgc agctgtcttt cgtgatattc cctaatattt tcgattgcct gcctaatcac 3173881 ctgaagaaga cgtgaatcca gtgaggtgta tgcctcctca aattcttctt ttgtgaccag 3173941 cgggctgtct atttcgatgc agtcaaattt cgccgtgtag ctgcgaaccg cctgatcacc 3174001 gtttgcttta acatcttcaa taatggaccg gaccgtcttt ctttgctctt ccgttccggc 3174061 atcgatggaa cgcttgagag aaagccgttc cgctccgctg atggttttga tcttcatttt 3174121 gccgtctctc cttccacaac gagagatagg cgggatgcca tttcgtcaat cacatcgtct 3174181 ttcatgcgat agcttaccgg gttgacaata aagcgagagg taatgtcaca aatgtgctcc 3174241 gtttcaacaa gcccattttc tttcagcgtc tgtcctgtgg aaacaatgtc cactatccga 3174301 tctgcaagcc caatgagcgg agccagttca attgaaccgt tgagcttaat aatctcgact 3174361 tgttctccct gctctctgaa ataactggaa gccacattcg gatactttgt cgcgattctt 3174421 ggcgctactc cgctccagtc tgtattcgga agtccggcga cagctaagtg gcatttgctg 3174481 atgtttaaat ccagtacctc atacacatcg cgttcctcct ccagcatgac atccttgccc 3174541 gcaattccga cgtctgccac gccatgctcc acatacgtgg ttacgtccat cggcttcgct 3174601 aatataaacc gaagattttc ctccggcaca tcgatgatca gttttctcga atcttcaaac 3174661 tcctcaggga gcctgtagcc tgcctgcctc agcagccctg ccgcttcttc aaatatccgg 3174721 ccctttggca tcgccattgt gagtaactta cccattttgc tcttcctttc tggcaccgat 3174781 aaaataagtg acgtttgcaa aagattttgt catctggtcg atattttcta ttcccgataa 3174841 atcttgaaga accactttgt tccctttcat gcgttcttca ttcgcataag cgatggcttg 3174901 cgcccgctgc tctttgctga aaataacagc gtctatttca caaggttcgt ccttcatatg 3174961 aagggcttca atcagccggt cgatccgaag cccgaagcct gttgccggtg caggtgaatc 3175021 aaaatggccc agcagcttgt tgtaacggcc gccgcttcca atgacaaaac cgacattctc 3175081 ggcgtacact tcaaataaaa tccctgtgta atagctcatg tggctgacca tattcagatc 3175141 caggcggaca ttttccgtac atccgtaatc ctcaagaatg tcccacagcg ccttcagctc 3175201 atcaaccacg ctttttcctt gcgcagaatc gacgatttcc tcggcacgtc cgcatacttc 3175261 tataccgccc cgcagttcaa ggagctcaag cagcctgctt ttatcaatgg aggaaagcgg 3175321 gagagacttg acatgctctc tgtagccgac gtagttcttt tcatataaga acctccgcag 3175381 cacatcagct cgttcaacgt ttccgagcac ctcaacaaac aaagcatccg caatgccggc 3175441 atggccaatt gcaattttaa aggatgccag cccagcgttt tttaatgccc cgacgactaa 3175501 agcaatgacc tccgcatccg cgctcgtcgt gccgtcaccg attaactcca ctccgacctg 3175561 ctcgaactca gccggacgtc cgccttcacg ctcctgagcc ctgaatacat ttgccgcata 3175621 gccgactctt agcggatgac cgtgtttcag aagcttcgat gccgccaccc ttgcaatcgg 3175681 ccccgtcata tccgggcgaa gcaccaatgt cttgccgtcc tgatcaagta gcttaaacag 3175741 ctgctgctct tcaattgctg actggacgcc aacggtatcg taaaactcca gtgtcggcgt 3175801 ttccataaat tgatatcccc atttatcaat caaatcggtt aacgatcgtc tcaccttttt 3175861 tttcgtttcg tataaaccgg gcagtgtatc tctcatgccg tgcggttttt caaacataaa 3175921 catcaacccg agcacctccg ctgttatctt atgaaggaaa attccgaatc ctttagttcg 3175981 ctaatatgat aatatgttag cagatgaaag aatgaaaatc aacgcttaac ttcagtaagg 3176041 atatttttag ttcaaatatc cttctcctca ttatgaaaaa atcatgaata atgtattaaa 3176101 ggtacgtaat atctcaaatt ctttatgttt ggcatgctat aatacaaatc aaatagagaa 3176161 caaggagata aagatgaaaa cactgcgaac tctatgtgtc ctgatgattc tttcaggcgt 3176221 tatttttttc ggacttaaaa tagatgcaaa agatatagat attccttttt tgaacagcct 3176281 taaaaaagtg gtttctgata gcgatacaga ctcagctgcg aatagcaaaa aggagctgaa 3176341 gggaagcgca aaaccgctgg atgtcatcct ttacaatcaa atggacgcac cccggctcta 3176401 taacggctgt gaagtaacaa gccttgcgat ggtgctgaat tatgcgggat acgacgtgac 3176461 aaaaaatacc ctggcaaatc aggttgccac agtgcctttg acatacagca gcggattaaa 3176521 gggtgatccg aatgacggat ttgtcgggga tatggcgaat ggccctggtc tcggtgtcta 3176581 ccatcgaccg atctatcagc tggcgaaaac ctatgcggga gacaaagtgt ctgatctgac 3176641 tggaaaaagt atttccgctg tttatcagca gcttgaaaaa ggcaatccag tttgggttat 3176701 tacgacagcc aactttacgc cagttgacaa catgcagaca tggaaaacgc caaacggaac 3176761 gatagaaatt acgtacagcg aacacagcgt cgccgttacg ggatatgatg ataaatatgt 3176821 gtatctcaat gatccgtatg gctataaaaa cagaaaaacc gatagaacaa gctttgaaaa 3176881 agcgtggaaa caaatgggca gccaggccgt ggttattcaa aagtaaacac ctgaagcctc 3176941 actatgctct attctgagca aatacgacaa tattcatgct ttttgtatca atcggtaaga 3177001 tcgattcatt ttccattttt cacccaaaat tgtctttact ttcaggctgt ctgtttttat 3177061 gattaaagca gattcagcct tgccccgatc tatgcgagag aagccggtgc aagtcgctga 3177121 cgcttctctt gcaaaaaatg aaagatatcc ggggaggatt tatcattgaa aaaaatcgtg 3177181 tctatcctat ttatgttcgg tttggttatg ggtttcagcc agtttcagcc atcaaccgtt 3177241 tttgcagctg acaaagtggt gcacgaaaca attatcgtac caaaaaatac aacatatgac 3177301 gggaaaggac agcggtttgt ggcagggaaa gaattaggtg acggaagcca gtcagaaaac 3177361 caagaccctg tttttcgtgt ggaggatgga gcaaccctga aaaatgtggt gcttggtgca 3177421 cctgcagctg atggcgtgca cacttatgga aacgttaaca ttcagaatgt gaaatgggaa 3177481 gatgttggtg aggatgcgtt aacggtgaag aaggaaggaa aagtgacgat cgacggcggt 3177541 tctgctcaaa aagcgtcaga taagatattc caaatcaata aagccagtac cttcacagtg 3177601 aaaaatttca cggcggataa tggcgggaag ttcattagac agcttggtgg ttcaaccttc 3177661 cacgttgatg tgatcatcga caagtgcacc atcacaaaca tgaaggaagc gatattccgg 3177721 acggacagca aaacaagcac ggtcagaatg acaaatacac gctactctaa tgtcggtcaa 3177781 aaatggattg gtgttcagca tatttacgaa aacaacaaca ctcaatttta acaaaaaaag 3177841 tccgctgatg ttattcagcg gactttttca atctttcttg catttcttcc ttcgtataga 3177901 tgatcctcat cggatttccg ccgacaaatg ccccgtcagg cacatcctta tggacaagcg 3177961 ttccggcgga cacaactgcg ccatctccta ttttcacccc gggcagaatg gtcgtgttgg 3178021 caccaatcat cacttcgtcc ccgatcagaa ctttgccgat ccggtattcg tgaatcaaat 3178081 actcatgggc cagaatggtc gtattgtacc cgatgattgt atttgttccg actgagatct 3178141 tttccggaaa catgatatct ggcatcacca tgagggcaaa ggatgtctgt tttccaacct 3178201 tcatccgcag aaatgtgcgg tacagccagt ttttcatccc tataaacggc gtatatctcg 3178261 caatttgaat gacaatgaaa tttttgacga cctttaaaaa aggtaccgtt tgatagacat 3178321 gccacagtga gttggccccc gagaccggat gacgatctgt ttttctcaca gattacttca 3178381 ctccaacgat ttgtaataga tcactcattt tctcaagcat aaaatccggc tcatgcttcg 3178441 ccagcatttc cggcccttta atcgtccatg cgactcctgc cgtttttgta ccggcgtttt 3178501 tccctgccag cacatcatgg taattatcac cgaccataat ggcttccgcc ggctcgcttc 3178561 ctagctgttt cagcgctaac agcacaggct cgggatcagg ctttgcattc gtcacatcat 3178621 caagggtgac aactgtttca aagaattcgc cgattcccgt gagcttgagg cccatattga 3178681 cagtatctct taattttgtt gtcacaattc ctaatgtaaa gccggctttt tttaatgcat 3178741 ccagggtctc atataccgtt tcatattcag tgacgagtga atcatgcatg tcatgattgt 3178801 acgctctgta catagcgatc atatcctcgc atttatcagg gtccatcgaa gagaacgtat 3178861 caaaaagaga cggcccgata aatgcaagga catcttctcg tttatacttg ctcggataat 3178921 aatgctccag tgtatgcaaa aaggacgcga taattaattc attcgtatta ataagcgttc 3178981 cgtctaaatc aaacagaatc gtcgttactt gtttgtcact catattgctt cctttccaac 3179041 cgctgagggt ttccattttt tccacgtgtg cgcaatagcc attgtcagca gaactgctgt 3179101 ggtgacacga atcaaaagaa gcggccagac cggtatgcca agcggaataa agacaagtgt 3179161 atcttccacg accgcgtggc aggcaacgag aaatataaat gccaatgtca tgtcccgctt 3179221 gctcacgccg tcatcctcga cagctttgat catgacaccc gctccgtagg ccagaccaat 3179281 cgtcagtccc gtcaccatcg tcatagacgt atttttattc atgccaagca gctgcgtaaa 3179341 cggcgacagc cacctggaaa accgataaag ccagcctaaa tctcttaaaa actggatgat 3179401 aatcatcagc gggatcacta ttgccgccag ctgcaaaaca ccaagtccgg ctttcgttaa 3179461 tgcttctgcc aacattccta gccagctgtc tggcgccgcg ctcttcgcag cgataaaacc 3179521 gtactgcgcc gtttcctttc cgccatgcca aatgaggttg atgacgatgg ctgacacagc 3179581 ggccaaaccg atgcgcacgg ccaatatgac gccaattctg ataccaacct ttgcggcaac 3179641 tgtcgattcg ataatcaagt tatgacagaa agaaagcata acagctaaaa taaagacttc 3179701 tttcacagat aaatccaatg ttaaaatccc ggcaattccc gcatacagat tcagcatatt 3179761 tcccagtaca agcggaatgg ccgcttcacc agaaagcccg aagagaccca ttaccggtgt 3179821 gatcagccgt acaagccaat ccatgacagg ggtatgctgg agcaaagtga ccaatagcgt 3179881 taccgggaaa atcactttac ccagcgtcca tgttgtttga aaacctgctg caagaccggc 3179941 cagaaagatc ttcttcatcc ctcatccccc tttgttgacg tctactccgc gtaccgctcc 3180001 ttcgagtatc ccttgacgcg tctgaagatg atggctgcca cagccaaaac aatcaatacg 3180061 attgaaatca cctgagcgat gcgaagtgaa tcagtcagca ttaagctgtc agtccgcatt 3180121 ccttcaataa agtatcttcc gattgaatac caaatgatat agatcaagaa catctcgcct 3180181 ctacgcaaat tcgctctgcg cagcagcagt aaaacaatga cgccgacaaa gctccatagt 3180241 gattcatata aaaaagtagg atgataatat tgcccattga tatacatttg attgatgata 3180301 aattcaggca ggtgcaggtt ttctaaaaag gctctgctga cagcctcgcc gtgcgcttcc 3180361 tgattcatga agttccccca gcggccgatc gcctggccga gcaaaatgct gggcgcggca 3180421 atatccgcaa gcttccagaa cgaaaggttt ttcactctcg aaaacacata acccgttaaa 3180481 atggcgccga ttaatccgcc atgaatggca atgccgccct tccaaatctt aatgatttct 3180541 cccggatgtg ccgcataata gtcccattca aaggcaacat aataaattcg tgcgcaaata 3180601 atcgcaattg gaatggcaaa caggacaaga tcaataaacg tatctttctg cagcccccgt 3180661 ttttcacttt ccctcatcgc tatccacagc ccgagcaaag cgccgagacc gataatgatt 3180721 ccgtaccagt ggacggctaa cggccccagc tgaaatgcta tcggattgag tggttctatc 3180781 gcttcattca tttaacgcca actcctattc ttcttgttca ccgtcttcaa tgacgtccgc 3180841 cagcttgttg gtaaattgtt cagcggcatt cagccccatc cgcttcaatc tgaagttcat 3180901 tgctgccact tcgatgatga ctgcaagatt tcggcctggg cggacgggaa tcgtcagttt 3180961 tgtaatttct gtatcaatga ttttcatggt ctcttcctca agtccgagcc ggtcgtattg 3181021 cttgccctgc tcccagagtt caagattcat gacaatcgtg attcgtttat tgcttctgac 3181081 cgcgccagcg ccaaatagcg tcatcacatt gataatgcca aggcccctga tctcaagaag 3181141 gtgctcaatt aattccggag cgtttcccac aagagtatcc tgatcctcct gccgtatttc 3181201 aacgcaatca tcggcaacaa ggcgatgccc tcttttcaca agctctagcg ctgtttcgct 3181261 ttttccgacg ccgctttttc ctgtgatcag cacgccgaca ccatatatat cgacaagaac 3181321 gccatgaatt gctgtggtag gcgccagcct gctctcaagg aagttggtta aacggcttga 3181381 cagtcttgtc gttttcagcg gcgatctgag gacaggcacc ccatttttct cggaggcgtc 3181441 aatcagctcc tgcgggatgg gcatatctct agaaagaata atagctggtg ttacatcagt 3181501 gcacagagaa tccattcgct gctttttctc ctcttcagga agctgttcaa agaaagaaag 3181561 ctctgttttt ccgagaagct gcacgcgctc cctcgggtaa tatgtaaaat atccggcaat 3181621 ttcaatacct ggtcttgata ggtcactcat tgtaatcggg cggttaattc cttcttctcc 3181681 gctgattaat tccaaattga actgttccat tacgtctttt gtgcgaacct ttgccacgat 3181741 atgttcctcc tgttccgggc tgccccgagc ttgctcacaa tactttcatt ttatcacttt 3181801 cgggcttgaa cctaaaacag attttataaa aggggggaaa acacctcagc tggtctagat 3181861 cactagtctg aaaaagagta aaataaaggt attcaaattc cagaaaggcg gatcatctat 3181921 ggcagagagt cttcttatca aagacattgc gatcgtgaca gaaaatgaag taatcaaaaa 3181981 cggctatgtc ggaatcaatg acggaaaaat cagcacagtt tcaacagaac ggcccaagga 3182041 gccatattca aaagagattc aagcacctgc ggattccgtt ttgcttcccg gcatgattga 3182101 cattcatatc cacggcggct atggcgcaga tacaatggat gctagctttt ccacgctcga 3182161 catcatgtcg tcaagactgc ccgaagaagg cacgacgagc tttttagcca caacgattac 3182221 ccaagagcat gggaacattt ctcaagcttt ggtgaacgca agagagtgga aagcggctga 3182281 agagtcctct ttattaggtg cagaactgct cggcattcat ttagagggcc cctttgtttc 3182341 gcctaaaaga gccggagcgc agccaaagga gtggattagg ccttcggatg ttgagctttt 3182401 caaaaagtgg cagcaggagg cgggcggact gatcaaaatt gttacacttg cgccggagga 3182461 ggatcagcat tttgaactga tccgccattt gaaagacgaa tcgattatcg catccatggg 3182521 gcacacggat gccgattccg cattgctgtc ggatgccgca aaagcagggg cgagccatat 3182581 gactcatctg tacaacgcga tgagcccgtt tcatcaccga gagcccggag tgatcggaac 3182641 ggcgctggcc catgatgggt ttgtgacaga gcttatcgcc gatggcattc actcccatcc 3182701 tttagctgca aagcttgctt ttttggcgaa aggcagcagc aagctcattt taattaccga 3182761 ttccatgagg gcaaaaggac tgaaagacgg cgtatatgag ttcggcggcc aaagtgtgac 3182821 ggtaagagga cgaacagcac ttctttcaga cggaaccctt gccggttcga tcctcaaaat 3182881 gaacgaaggc gcacggcata tgcgtgagtt tacaaattgc tcttggacgg atatagctaa 3182941 tataacttct gaaaacgcgg ccaaacagct gggcatcttt gaccgaaaag gcagtgtgac 3183001 tgtgggaaaa gatgcagatt tggtgattgt cagcagtgat tgcgaggtga ttctcaccat 3183061 ttgccgcgga aacattgcat ttatatccaa ggaggctgac cagatatgaa agtaatggaa 3183121 tgtcaaacgt atgaagagct aagccaaata gcagccagaa taacggcaga tacaatcaaa 3183181 gaaaaacctg atgctgttct cggtttagcg acgggcggca caccggaagg cacgtatcgc 3183241 cagctgatcc gcctgcacca aactgagaat ctctcatttc aaaacatcac tacagttaat 3183301 ttggatgagt acgccggact ttcaagcgat gacccgaaca gctatcactt ctatatgaac 3183361 gaccgttttt ttcagcatat cgacagcaag cctagccggc attttattcc gaatggaaat 3183421 gcagacgatt tggaggccga atgcagacgg tatgaacagc tagtcgattc cctcggcgac 3183481 actgacattc agcttctcgg catcggccga aacggacaca tcggctttaa cgaaccggga 3183541 acgtctttca agtcgcgaac tcatgttgtg acattaaatg agcaaacccg ccaagcgaat 3183601 gccagatatt ttccctccat agacagcgtg ccgaaaaaag cactgacaat gggaattcaa 3183661 acgatactct caagcaagcg cattctgctg cttatttctg gaaaaagcaa agcggaagct 3183721 gttcgtaagc tgttagaagg aaacataagc gaagattttc ccgcatctgc tttgcacctg 3183781 cattccgatg ttacggtttt gattgatcgt gaagccgcgt cattaagacc ttgaaaggaa 3183841 catgctgact tatgaatatc aataaacaat cgcctattcc gatttactat cagattatgg 3183901 agcaattaaa aacccaaatt aagaacggag agctgcagcc ggatatgcct cttccttctg 3183961 agcgcgaata tgccgaacaa ttcgggatca gccggatgac agttcgccag gcgctttcta 3184021 atttagttaa tgaaggcttg ctctatcgcc tgaaagggcg gggcaccttt gtcagcaagc 3184081 caaaaatgga acaagcactt caagggctga caagctttac cgaggatatg aaaagccgcg 3184141 ggatgacacc gggcagcagg ctcattgatt atcagcttat tgattcaact gaggagctcg 3184201 cggctatatt aggctgcggg cacccctcct ctatccataa aatcactcgg gtgcggctgg 3184261 caaatgatat tccgatggcg attgagtcct cacatattcc gtttgagctt gcgggtgaat 3184321 tgaacgaatc gcattttcag tcgtcgatct atgatcatat tgaaaggtac aacagcatac 3184381 cgatttcccg tgcaaaacag gagcttgagc caagcgctgc caccacggaa gaagcgaata 3184441 ttcttggtat tcaaaaggga gcgcctgtcc tattaattaa acgaacaaca tatctgcaga 3184501 acggaactgc ttttgagcat gcaaaatccg tatacagagg cgaccgttat acatttgtcc 3184561 actatatgga tcgtctttca taaaaaaagc ctccaaccct ttttaaggat tggagacatg 3184621 gcgaaaatca aactggtctg gtgccggacg atatgtttct tttttcgtct tgaacttcca 3184681 gatcggtgat ttcgttttgc cgttaaaact gtcttccact ataatgtacc aataataaac 3184741 agactgcggt tcaagatgat cccagcggaa ttcagctgtg tccccgctct tcacttgctc 3184801 ccgttttccg agctcttcat tggtatatac gttacattca aaataatcgg tttccacctt 3184861 tttgattctt ggcttcaaat caagcgaaag ggaaaattca tccttgttgc cataggtatc 3184921 cgtatcatag tagttcttat cctttacata cggagagtac gtcgatacgt gcaccatgtc 3184981 attggcttgg tcaaattgaa gcaaacgcaa atacccttgg ccgccttctg gcccgccctg 3185041 ataatcggcc agcatttgat gcacaagacg atccggtttc ccatcaccat catcatccag 3185101 ctcatctgtt tttctcatcg cactatgata atgcccgctc aacaccatca cgacattcgg 3185161 gttcggcttt acgatttctt tgaatatttt ctctccgatt gggcttctgt ttccgctgac 3185221 cagcaaatac tcatgaaaag ctaaaatggc catccggtca ggatgcttct tcagcacctg 3185281 attcatccac gcgatgtctt catccgtaat gccccatccc atgtacagca tgatataatc 3185341 attgccgttg ctagaaatca ggtcataatg tccgcggtta tttttatagg aaccgccata 3185401 atgaaatttt ttatcaaaac gatcgctgcc aaaatatttg ccaaacgccc tgtaggagcc 3185461 gtccttatgt ccgacatcgt gattgccggc cagcacgccg taaggaattc cgctcttatc 3185521 cagaacggac attgaccgat cagcgttttt ccactgtctg atatcggcgg aatcatctac 3185581 aatatcaccc gtgtggaaca catatttgat attgagctgc ttttgattat cttttatcca 3185641 ttcggtctgt ttatcaaaaa tatgcggata gctttcggcg taatactgtg tatcagacat 3185701 ccagacaaat gtgtacatat ccttcgcagg aggaatttca tcctgtacaa tcacattcat 3185761 tttcgactcc cgtacaaaat cggcggcaat cacagacgct ttcagcgtaa acggtttgtc 3185821 atccttcgcg acgaagctgt caacaggctg ccattcgttt gtccgataat tccaagcata 3185881 catcgtcacc tttctccccg gcaaagaact gcccttccag actgattctg ccagatcatt 3185941 ctcatcaatt gatggatcaa ccgtcacttc aaagcgatga taagggaaaa gctctttgtt 3186001 ttctgtcgat actgtttttc catcagcagc tgatacccgc tccaattctt tattcgtaaa 3186061 tggggtctcc ctttccggca caaagctttt cggcggttca gtcagtgacg cgtgcttaaa 3186121 tattttcaca tgattgcgcg ctgtatattg aaatccccta taaaaaccaa catccatggc 3186181 atcattcgtc ggatctttca cccgtacaga aagcttggcc ttatgcgtgt cggcttcgct 3186241 gtctataacc tccggctggt ccggatgctc tcgttcggtt ttaaatatcc tctcaatcac 3186301 tgttttattg cccgcgagat ccgttgctgt cacttttaga gaatgttttc ccggcaaaag 3186361 gtcagaagat gacgtatgat atgggagtgt aatgctttct ccatctaacg acgcctccgc 3186421 ttcctcaatt ctgctccatt tatcatacat atccgcctgc aggataaggt ttcctttata 3186481 cgtttgcccc tcggtgatat tcggctcaat gtgaggtcct gaattatcta cccgtacaac 3186541 caggctgaca ttttccttcc cgtcgcttgc ttgaatatgg tgagcgcctt cagaaagctt 3186601 tgatgtatcc cactccagca gctgtgatgt aaatagtccg tcaggcagat tgaactgaaa 3186661 ttgccagctt ttattcgagc gctgattatc gccaataaag agttccttct caggagacac 3186721 cctctgatct ctgatcaccg ttccatccga taacaccaat cgggcgtttt tgactaagaa 3186781 gtcatcacgg ttttcagccg tatcaaacgg agacaccttc gaacctgaac gtatcgtaat 3186841 acgctgcagc tgcttccctt tccgaagcag tgtctctggc aatggaacag aataggtgcg 3186901 gtatttattt gttgtatcat cgaacacctt cagcactttg ccttccatcg ttaccgcgtt 3186961 tttaaaataa aggttcgttt tcctcgtatc gaatgcaaaa tatacttctt tttccatcgc 3187021 gggctctgtc acttgttttt tcccgtcaat ccatagctta atgctgtcag ctcgcccttc 3187081 tgtcgtggct ttgagaaatt gagttcccga cagcgtgtct ctgttttcaa tattcatccg 3187141 cagaccgtgc gccttgcttg tttgtttaat atcaatcatt ttgaccggcg ttctcgcttc 3187201 attgatcccg tccccggccg ccacataata ctctagctga tccttcccga tcaattcagg 3187261 cgaatacaca atataatgga agagattatc gttgcggtct ttttcagcaa gaattcgctt 3187321 aaacggtttg ttctcatccg tccggtagta aaaggccact gttttcacta ggcttcggtc 3187381 ccgtatgtca gcccgcagct caatgctttc agcagggcgg acaggcttgc ggtcagtcaa 3187441 atcctcaatg accggctttt ctttatcgag cttgattttc cgtttctggt cgggcacctg 3187501 tgcctgtaat acggttccgg gagacggatt cttttccccg attgaaatgt tcagaagttc 3187561 tgctgttccg ttcagtggat acttataaag cactgatgac agccggcgca gcgcatgttt 3187621 ccgataatgc gcaaccgaaa tgtcctttcc tgtattcgtt gatatcacaa cggcccgcgg 3187681 cctcgtattg gccataccct ctgtctcgtc tatcaccgca agattttttc cttcttttag 3187741 ttgtgtctga taataacgat tgaaatccgc tgacgtcaat tctggatgcc cggcaggctt 3187801 cagccagacg acaaacgttt cgccggatgg tatcaagatc ctttcatcag gtctccaaat 3187861 cagatcggag tcaggccctt cttttgggta gcggtaacgg atatggtagt ctttaaaatc 3187921 aatcgttctg tcagtcgtat taaaaatctc aataaattca taaccgtctg cgcgtcctat 3187981 attcttcgta tcaaccgcca gctctgtgat cagaagctcc ggaatatggg caaggtcagc 3188041 ctggtatcct tcaagcttca gtttcttcgt ctccgactca acccgctgct tcccattcga 3188101 catcacaatg taatactcaa gctcgctgtt ccaaatcaaa cgtttcggaa tttgtgccaa 3188161 aaacttgcgg accgctccgg gggtcgggtc catcggcacc attttgtagc ccagctcatt 3188221 actttgttta taaaaaagaa aggcggaaaa tgcttgatac gaattatcgc gaacttgagc 3188281 ctcaatcatt agattgcttc tcatttcagc tttcacatca atttgaggag gattttcaag 3188341 caagggtatg taatgaggcg tttgaaatag ttcctgctgt acaacaggaa aagctttcga 3188401 ttcatgatgg ccgccagaca aaacggaaag aaaagacagt aatatagaag caataaccgt 3188461 gtatttcctc atcaaagcac ctcccttttc atgtattttg cgtctgaaca gggaagctta 3188521 tgagttcatt tttgtgcata aagaacaaaa aaacgtctgt ctcttgaaaa ttccactatt 3188581 acccagtaaa ctaaggatag ttaaccagtt aacaattaaa tcagagaggc aaattgatgg 3188641 acaacagcat tcatgatgaa ttatttcaag ctatacaaca attcgcatta aaaagggata 3188701 aacgcgtctg gcaaaaggtg cagataccat ccattggcat atcctcacaa catcacgatc 3188761 acctcaaaaa agactggact ttgacccagc ttcacattgt ttcctgcata cataccagcc 3188821 aaaatgtgaa caacagcttc ttagcatccc gtttacacat ctcaaaagcc gctgtttcaa 3188881 aagcggttca tgctttgttg aaacacaata tcattacagt gacaaaaaag cctggcaaca 3188941 aaaaagaaat tttttatacg ctaactgata gcggcagaaa attggcggca ttacatgaac 3189001 agcttcatga gaaagcaaag gagcaatata aacagctttt caatgaattt tcaattgatg 3189061 atttaaaaac agtgactgcg tttttcaact tgtggatcaa atatatgtaa aaagagtctc 3189121 acccgcatgg gagagacctt tggaattcta ttatgccccg tcaaacgcaa cgagaagtga 3189181 aacaggtccg cgtgtataca gaccggactc agcataacaa aaatcttcct ctaatctgat 3189241 attccgcatc ttatccagca caatattagc tacaatttcg atttcgtttt tggcaaaagc 3189301 tgctcctaca cagttatgaa tgccggatcc gaaagcgaga tgccgggcgg cgccgctaaa 3189361 agcgctcttg ataccaagat cttcccgatg aatattaaac acgtcaggct gttcaaatgc 3189421 ttcagggtcc cggttagccg caccgatcat acaaaaaaca atcgtatctt ttttgatttc 3189481 cataccgccg accactgtat cttgggacag ctgccgcgga atcagctgaa ccggcggttt 3189541 ataacgcaat gtctccgcaa tggctctcgg aactaacgaa cggtcagcca aaacatcatt 3189601 catctgctca ggattgttga gcaaatggta gatcatcagt gccagcgtct tatcagccgg 3189661 ttccgttgcg gctaacagca cattaagaat cagtgcgagt atatccttgt ccgacagcgc 3189721 catgccttca tattcagaag tacataggat cgaaattaaa tctgatcccg gattgacgcg 3189781 acgttcttta atgaccggca tcaagtattg ggaaagctgt tcgctgcacc ataacgaatg 3189841 tgcccgcgct tcaggagatt gagagatact cgtgataaaa tcggcaactc cgctgtgcca 3189901 ctcagagatt ttttcatggt ctcttttatc cagcccgagc atgtccatcg tgacgcacac 3189961 cgcaaacgtc tttccaaaat cattgacgag atcacttttc cctctttcaa gataaggcgc 3190021 taacaagttt tctgcatttt gtttaatcaa tggagacaga tgatccagtg cgtcaccgat 3190081 aaagcttctc actacaattc ttcttttggc agagtgttct tttccatgca tttgggccag 3190141 cacagggcct cgcatgactg gttcggcacg ctcaacaagt gatttcgtcg tgaagatatc 3190201 cggatgctga aggatatagc ggacatcatg atagcggctg ataaaataac tgtctatcga 3190261 ctcttcataa tgaaccggat cttcctcccg cagttgtgaa aaataagcat atggattgtt 3190321 ttgaaattga tcagaaagca cactaaacaa tttaatcgat tggctcatgt tttactcccc 3190381 ctatcatcct tcagatgtga tccgtttctc agaaagcatc tgcgccattt cctgtacaat 3190441 gagataccct tgattcggcc gcatacaaat agaaaattca tggttactga tcttctcacc 3190501 cagcttccac ggacgatgat aagcaaggag tgtctcttcc acctctaaaa tatccggagc 3190561 tccgataaaa aacggcagct cagctatgac atattccaca gccaaattca gcatatcctc 3190621 actgacttct tccatcatca aactgacgcc ccgcgcacgc ccgattatcg cttcacgaga 3190681 catgtccaaa caagcatgtc gaaaatgagg ctgctcaaaa aatgcatgtt caacttcttg 3190741 tctcaacagc tggtaggctt tgttatctat aaaatcagaa aatgtatgaa tcgccttcgg 3190801 atccccgcca tgagccacaa gggctctttc tgcaaatctc ctgtttcgtg atacctcttt 3190861 ccttactttt cgttcagcct ttcctctcgg agttccaagc gcttctagaa gattagccgc 3190921 ctcatgccct gcaagtaaaa ctgaaacgct tttaaattga gctttcgccc atccaattaa 3190981 tctgtaaata taatcctctg aaaacctgct gttaaatggg ctgatcccca ccaaaacatg 3191041 cctgcgccgt tcaaatattt ctctgcagtt ttctgttaat gcctcagcaa taaaatgcac 3191101 agaccttctt tccgttacca ttccggtcat ctcattcacc cctaaaactt atcccgcttt 3191161 aagtcatcac cctcaaatac aagatggaat agctagaaca actgaacaag acgaatggca 3191221 ggcatcactt aaagtttcca aatgtttttt aagattttaa taatcatttt caatacccat 3191281 atcatgataa atgtttacta gtaaacatta gtcattttat cccttttcct tccaaacgtc 3191341 aatatgatct gtgcccaaat atttgaaaat aaatgtaaac atcacatttt ccacacactt 3191401 tttacacgca tattcagcat gacatatcaa caaatagtct aaacaccaac aattgacaac 3191461 gaaaacaaga aaagataaaa taaaattgtt caccagtaaa cgatttgttt tattgtttca 3191521 tcgtaaacta ttattcctaa gaaagaaggt agcctatgtc tgatttgaca aaacagatga 3191581 tatacgacat atacgtgaga ctgctgcacc ttaatgaaca aaaagcgaac acttcacttc 3191641 agcaattttt taaggaggcc gcagaagagg atgtagctga aattcccaaa aatatgacaa 3191701 gcattcacgt cattgactgc atcggccagc atgaacccat taataatgcc ggaattgcca 3191761 gaaaaatgaa cttatcgaaa gcgaatgtaa cgaaaatcag cacaaaactg atcaaggaag 3191821 aattcattaa cagctatcag ctgacagata acaaaaaaga agtttatttt aaattaaccc 3191881 gtaaaggcag acggattttc gacttacatg agaaactgca taaaaaaaag gagctggctt 3191941 tttaccaatt cctcgattca ttttcacaag aagaacaaaa ggctgtattg aagtttctag 3192001 agcagttgac gtcaacactt gaagcagaac aaaccgatgg gactccagac aaacctgtaa 3192061 agtaaacaaa aaggcggtgt acactttggc tcatacaaaa tcaaaggcag tattgatctt 3192121 atacactgtt tgcttcagtg cattttttgc atctttaagc cagaacattt attcacctat 3192181 tcttccgatc attaaagaat cattccatgt ttccacagct atggtgaacc tgtcagtctc 3192241 agtttttatg attgtgacag caataatgca aattatatta ggagcgatca ttgattttaa 3192301 aggcgctcgg atcgtcttga ttaccggtat tctggcaacg gcagcagcca gcatcggctg 3192361 tgcggtgact actgacttta ccttgtttct gatattcaga atgatacagg cagccggttc 3192421 cgcagcactg cctcttattg ctgccacaac gatcggacag ctgtttacag gaaatgaacg 3192481 cgggagtgca atgggaacgt atcaaatgct cctgtctgtc gcaccggcta ttgctccagt 3192541 tctaggagga ttcataggcg gagcagccgg atacgaaggg attttttgga tacttgcggc 3192601 catctctatc gttttgctgg tgacaaacag catcaccttt cctaaagatt ctccaactga 3192661 atctatgcag caagccaaag gcaatgtgtt cgctcattat aaatcaatat ttacaaatcg 3192721 aacagggaac gtcattttga ctttaagttt tgttctcttt ttcatttatt ttgcagtaat 3192781 tgtctacctc ccaatattgc tgacagagca ttaccatata gatgtgggta tagcaggact 3192841 gttatatttg ccgctggcgc tgagcacgat tgcaggtacg tttctgttta aaagaataca 3192901 ggcaaaaatc gggctgcaca ccttgtttat cggaagcaat gtgattgccg cctgcagcat 3192961 cattttattt gctgttacac attccgtttc tctcgttctc atggctctga cgctggcact 3193021 gtttggcatc tcgatggggg ttattcctcc cttgtactct acaatgatta ctaatgaatt 3193081 tgagcacaac agagggagtg caatcggaat gtttaacttt atccgatata caggcatggc 3193141 agcaggtccg atggtatctg cctacttgct cacaatgatg ccgtctgcca tgtcctttag 3193201 cctcctaggc cttggatttg ccgcattgag cttttgcctt cttccgccaa tgttttcgcc 3193261 gcagaagcgc acgaaacaaa aaaagcacca catgtaaaaa agctgccttt gcgggcagct 3193321 ttttttattt ttttctaagc ggctctaaaa tgcctttttg aatcagcaaa tggaagaccg 3193381 acaggataac ggatgcccat atcgctgtgc cgaagccgtc gatttgaaag ctgtcaccca 3193441 taatggacgc ggtcatcata agcgtgatgg cgttaatcac aaacaagaag agtccaagcg 3193501 tcaccatggt gaccggcagt gtaaatataa ttaaaagcgg tttaatcagc acgtttaaga 3193561 tcgataaaat gaggctggcg ataatcgctg ccccaatgct gctgatatgg atggagtcaa 3193621 tatatccatc aatgacgatt aataacaatg cattgactaa aatgctgact gcccatttta 3193681 ccatgtcatt tcatatccct ttctgacggg acgataaaaa tccaaatgat ataaatgagc 3193741 aaaaccggca agacacttgt cataatggct aagatgacag ttatgactct gaggagtgat 3193801 gcgtcccaat tgaaatattc cgcgagacct ccgataacac cggcgatttt cttatttttt 3193861 tctgagcgat aaagcttatt cattcgatca cctctgtgag tactttagtt tgatggcgcc 3193921 tgttagtgat tctgagaaga cggtgatgtt ttgatcatgt gcctgatttg aagtgaacat 3193981 catttctttt tgaatcgtat catttttttc cttcagcatc tctacatcca ttaattcatg 3194041 ggacagcgta ccaagattgc ttttcagctc tgccttcact gcgagatcgt ccggaattgc 3194101 aagctctaca tttccagtcg ttgtttttgc ataaatggag cggcagtctg attctgttac 3194161 gttaatcgca atatttccgt taaagctttg aacgtcaatg gattcgcttt tccctcggag 3194221 atcgatcaat ccgttaatgg tttccgcttc tatcgtaccg cagctgtggc ttgcgagctt 3194281 aatttgcccg ttggccgttt cagctatggc tttttcggct gttaaatacg agaacgacag 3194341 cacgccgttt gtcgttttcg ctgagaactc ttttacatgt aaatgttccc ctctgactgg 3194401 accgttaaac agcttcaccc gaatcttatc atactccttc tgaggaatat acaaagtgac 3194461 attcgttttc atcgtctttt tctcagtacg gataaaaaac ttattacctt tgatttcaca 3194521 ttcaatatgc tgaagaaatg cgtgtctcgc cgcatcctgg ctgtcagcgc gatatacctt 3194581 cgcctggcat tccgctctga tatcgtcatc ttcccaaggg acgatattta cgctgccatt 3194641 ggcaatttgc agctcaacac tggaaaagtc agtatcttta aattgaaaaa tgtgctgaac 3194701 atcatacgca tggccaaagt ttaaatcaag gtcaacttcc ttgacctttt tcacagcaga 3194761 atcaatccag tcaaacagct tggctcctaa agacggtttg ccgctttctt tttttgccgt 3194821 tgtaaatggc tcttcctcgt catgaacgtg aactgagagc gctgtgattt tctcttcttt 3194881 ttccttgtag tcgctgtcaa gcttttcaat cagtgtcaaa gcttcttgtg ctgtaagctt 3194941 tccttcctca acaagcttaa ggattcgttc cttttcttgc ttcattacga tctcctcccc 3195001 attgtctact tatgctgcac gcaggacctt aatgccctga atcacattcc aaatgataat 3195061 gccaatgaca actaagaaat aaataaccgc tcccccgatg attacaaata caggaagcaa 3195121 gctgtctcca tcaatcgcaa cggctccgcc aagtaaagca ataaaaagga acagccagcc 3195181 gacaaacgga acaatgtgag aaataagaga gcgtatcgca tggcgttttg tttctttctc 3195241 atttacaaca aaatatgcga caatcggcac aatgattggc gcaatgaaca cactgaaata 3195301 acaaagtgat gcaataatag cttgattacg gttcaattca ttccacactc ctattgtgaa 3195361 ttgtccatga caaaagatca gggacgtttt acttatttat acgtttaaaa tctcttcagg 3195421 tttcaaattc attctttaga catgctccga tttacggaaa ttggatttta aaaagtttta 3195481 gaagtagaat cttccggcta taccgattac aatatgtaaa aagcttacgg caaccaagga 3195541 ggctggacaa gcaatggaga aagatcccag tgactataca gtaacacaag aatcagtgtt 3195601 aaagctgatt caggaacaaa aaagaatgaa tcgtgaaatg atcaccgagc ttgagcagat 3195661 tcacggaccc ttcccgatct ctcacgatat ccaatatata aaagtgctgc tcgacagcag 3195721 caacacacat attgttcaag atttaatgag tgtaagtaag cagctgtata agaagacttt 3195781 gtaattgcgg aaaacatatc attcattata actgaaacaa agctaaaggt tagatgacaa 3195841 tatcttgcct tttttgtttt gaaaaaacaa gtgattccct ggctgtcaca aaatgattgt 3195901 aacaaaaaaa gcctgccggc acatccagtt aatggactct gtcggcaagc tgtaactatc 3195961 agaaagagat agccgttcaa aattaacgta acaattgaag cacgttttgc ggctgttggt 3196021 ttgcttgagc aagcatcgct tgagaagctt gagaaggaat gttgttcttt gtgaactcgc 3196081 tcatttcttt cgccatgtca acgtcacgga tacgggactc agcagctgtc aggttttcag 3196141 aagaagcacc aaggttgttg attgtgtgct ctagacggtt ttgtaccgca ccaagtttag 3196201 cacgttggtt tgagacattg ttgattgcag tatcaatact ttcaagttgt gtatcaaaag 3196261 gagtattagc aaaatctgtt acattaagtg cgtttactcc taaagcagtt gatgacatgc 3196321 tgtcaatgtt aactgtaagc tgctggccag catttgctcc aatttggaaa gtgaaaccat 3196381 cagtttcagt accatctaat aactttttgc cgttgaattc agtacgattt gaaatgccat 3196441 caacttcctc aataagcgca tccatttcat ctttaattgc accaagatct tctgcttgtt 3196501 gtgtacctgt gtttcctgct tgaacagtaa gttcacttct aaacctatta tgccgtaaag 3196561 aaaaagcttg cctgctaagc ccaaggatgg acttgccgac aagctgtccc ctcttaacag 3196621 agggttttaa gatgtagctg tttcttttgc tttcaagagc gatttcatgc gtgttttgtc 3196681 acgttcgata acaggcttta aataacggcc tgtatacgat tcttcaactt cagtgatttc 3196741 ctcaggcgtt ccagacgcga caatggttcc gcctccggct ccgccttccg ggcccaaatc 3196801 cacaatgtaa tcggccgtct taatgatatc aagattgtgc tcaataacca gtacagtgtc 3196861 tccgttgtct accaaccgtt gcagcacgac aagaagcctg gcgatatcgt cgacatgcaa 3196921 acctgtcgtc ggctcatcta aaatgtagag cgtacgtccg gttgagcgtt tgtgcagctc 3196981 tgacgcgagc ttcacgcgct gcgcttctcc gcctgacaag gtcgtcgccg gctggccgag 3197041 cgtaatataa cctaaaccaa catcataaag ggtttggagc ttgcgtttga ttttcgggat 3197101 attttcaaag aaagaaagag catcttcaac cgtcatatca agcacatcag agatgctttt 3197161 tcctttgtac gtcacttcaa gcgtttcacg gttatagcgt ttgccgtgac acacctcgca 3197221 tggaacgtat acgtcaggaa ggaagtgcat ttcaatttta ataatcccgt ctccgcggca 3197281 ggcttcacat cgtccgccct tcacgttgaa gctgaaacgg ccttttttat agccgcggac 3197341 cttcgcttca tttgtctgcg cgaatacatc acgaatgtca tcaaatacac cggtgtatgt 3197401 cgcagggttg gatctcggcg ttcttccgat tggcgcctgg tcaatgtcaa tgactttatc 3197461 taaatgatcc aaacctttaa tctctttatg gctgccgggc ttcgctttcg ctttatgaag 3197521 cttttgcgcc agcgccttat gcaaaatttc attaacgagt gtactctttc ctgaaccgga 3197581 aacacctgta actgctgtaa acgtcccaag cgggaacttg gcattcactt ttttcaggtt 3197641 gttttctgat gcacctttaa tttcaatgta acgtccgtcc ggctttcttc tttcaggagg 3197701 caatgggata aactttttcc ctgataaata gctgcccgtt aatgaatttg gatcttccat 3197761 cacttcttcc ggcgtacccg cagatatcac ctgtccgccg tgaatgccgg ctcccggtcc 3197821 aatatctatt aaataatctg ctgccatcat cgtgtcctca tcatgttcga caacaatcag 3197881 cgtgttcccg aggtctctca tatttttcag agcgctgatc aagcggtcgt tatcacgctg 3197941 atgcagaccg atagacggct catctaaaat ataaagcaca ccggataaac gcgagccaat 3198001 ttgagtcgcc agcctgatgc gctgcgcctc tcctccggac aatgtacccg ctgccctgct 3198061 caatgtcagg taatcgaggc cgactttgtc cagaaagctt aagcgctcca caatttcgcg 3198121 caaaatcaaa ttggcgatct gcatatcctt ctcagaaagg gtaagatctt taaagaaggc 3198181 aagtgcgtcg gcgacagaca gctcggtaat tttcccaatg tggcggccgt caatcagtac 3198241 ggcaagcgcc tctttcttta accgatagcc tttgcacgtc ggacaagact tctgagacat 3198301 atactgctcc atttgctcac gtatgaaatc ggagcctgtc tccttatagc gtctttcaat 3198361 gttgcgcaat acgccttcaa attgaatttc accttcgcgg atttgtccaa aatcattttc 3198421 atatcggaaa taaatcaggt catccccgct gccgtacagc actttatcca gttgatgctt 3198481 cggcaaatct ttgaccggca catccatatc aatcccgtag tgggtgcaga ctgcctcaag 3198541 cagctgagga taatattgtg agctgatcgg tgtccaaggg gcgaccgcat tctccttcaa 3198601 tgacaaatct tgattgggga tgacaagatc ggcatccact tcaagcttca ttccgagacc 3198661 gtcacacgtc ggacacgccc cgaacggact gttaaacgaa aacagacgcg gctcaagctc 3198721 accaattgaa aatccgcagt gcggacaggc atgatgctcg ctgaacatca gctcttcctc 3198781 accgatgaca tcgatcataa cccgtccttc acctaaacga agcgccgttt ccaatgaatc 3198841 tgacagccgg gctgccacgc cttctttcac gacaatccgg tcaatgacta cctcaatgga 3198901 atgcttcttg ttcttttcta attcgatatc gtcggaaagc tcagccatct cgccgtcaat 3198961 tctgactctg acatagcctt gtttcctaat ctgttcaagc actttgacat gagcgccttt 3199021 tcggcccgag acaatcggcg ccagcacctg aagcttcgtc cgttccgggt attccagaat 3199081 tctgtccacc atttgctcga tggtctggga tgtaatctca attccgtgtt ccggacaatg 3199141 aggcttccct actctcgcat ataaaagacg cagataatca taaatctcag ttaccgtacc 3199201 gacagtagac ctcggattgc ggctcgttgt tttctgatca atgctgatgg cgggagagag 3199261 cccctcaatt gcatccacat ccggcttatc catttgccct aaaaactggc gggcataggc 3199321 agacagcgac tcgacatacc gtctctgtcc ttcagcatat atcgtgtcaa aggcaaggga 3199381 ggatttacct gatccggaca aacccgtgac aacgacaagc tgatctctcg gaatcgttac 3199441 atctatattt ttcaggttat gcgccctggc tcccttcacc tctatccgat ccatagccat 3199501 ttgttcatca tccttccgct tttagctcta aaagtaaatc gcgaagctcc gcggctctct 3199561 caaagtcaag cgccttggcg gcttccttca tttcatgctc catctgttca acgactttct 3199621 ggcgttcttt cttcgtcatt ttcgacagct tcggcgcggc ttttgttttg tattccgctt 3199681 tatcctcagc tgctactgtg gcacgaatga catcgcgaat ttctttattt atcgttttcg 3199741 gcgtaatgcc gtgctcttcg ttaaaccgct cctgctgctc gcggcggcgt tttgtttcat 3199801 taatcgcaat ttccatagac ttcgttattt tatcggcgta cataatgacg cggccttccg 3199861 catttctcgc tgcccgtccg atggtctgga tcagcgaccg ctccgaacga aggaaacctt 3199921 ccttatccgc atccaaaatc gcaacaaggg atacttcggg aatgtccaaa ccttccctca 3199981 gcaggttgat gccgacaagc acatcgtact tgccaaggcg caggtcgcgg ataatttcaa 3200041 tccgttcaag cgtcttgatc tcagaatgca gatagtttac tttaatgccg atttccttta 3200101 aataatcggt cagatcctct gacatcttct tcgtcaaagt tgtcacaagc acccgttcat 3200161 tccgctcgat tcttgcttga atttcgccga tcaagtcgtc aatctgacct tcgattggac 3200221 ggacgtcaat aagcgggtca agaagccccg tcggacgaat gatctgttcg accatttcat 3200281 ctgtatgttc aatctcgtac ggccctggtg ttgctgatac atacacgata ttgtgcatat 3200341 gcttttcaaa ttcctcaaaa cgaagcggac ggttatcaag cgctgatgga agccggaagc 3200401 cgtgatccac gagcacctgt ttccgcgcct ggtctccgtt aaacatgccg cgcacctgag 3200461 gaattgtcac atgcgactca tccaccacga tcataaaatc gtctgggaaa taatcaagaa 3200521 gcgtatacgg cgttgaacct ggaggccgca gagtcaaatg tcttgaatag ttctcgatgc 3200581 cggagcagaa acccatttca cgcatcattt caagatcata tcttgtccgc tgctctaaac 3200641 gctgcgcttc aaggagcttt ccgttttcat gcatgacctt cagctgctcc tcaagctcct 3200701 tctcgatatt ttgaatcgcc ttctccattt tctcggcccg cgttacgaag tgggatgccg 3200761 ggaaaatcgc aacatgatct cggtcgccga gaatttctcc tgtcagcgca tctacttccc 3200821 gaatccgttc gatttcgtca ccgaaaaatt caactctgac acaatgctca tcacgggatg 3200881 ccggaaagat ttccactaca tccccgcgca cacgaaatgt accgcgctga aagtcgatat 3200941 cgttgcgggc atattggatg tctacaagtt ttctgagcag ctcgttgcgc tcaatttcca 3201001 tttcagtccg cagtgacacg accatttccc ggtattcctc aggcgaaccg aggccgtata 3201061 tacaagacac actcgcaata ataatgacat ctctgcgctc aaacaaagct gatgtggcgg 3201121 agtgtctcag tttatcaatt tcatcattaa tactagcgtc tttctctata aatgtatccg 3201181 tttgaggcac atacgcctcc ggctgataat aatcatagta gctgacaaaa tactcgacag 3201241 cattgttcgg aaaaaattcc ttgaactcac tgtaaagctg tccagcaagg gttttgttat 3201301 gggcaatcac gagagtcggc ttattgactt ctttaatcaa attggacacc gtaaatgttt 3201361 tcccagttcc tgttgcaccc agcagagtct gatgcttctt gccctcctga attcctttca 3201421 caagcttttc aatggctttc ggctgatctc cctggggctg atatttcgag actaactcaa 3201481 agcgatcttt cacaaaaata agcctccgtt tctttaacga aatcttccta tagatatagt 3201541 aacacaatgg aaagcaaaat cactaaaaat acgaactaaa gttcggtggt tttttatttc 3201601 cagctgtttt tgtgtataaa aaacctgctt ttaaaacgta aaagcaggta ttcagtcttt 3201661 atattcatta tgtccgattt attcttcttt tttctctgca gcttttttgg ccatatacag 3201721 tccgccagcc acaagagaca caacatccaa tcctacaata aaatacgttt ctgtatagcc 3201781 ttttaaataa gaggcaaaca gcaatgcagc tgttaaagcg atcgccacat aatgattaaa 3201841 ggtgactcta gtaaatagaa caacaagcat aaaagggaaa aacaatgcaa aaacggcttt 3201901 tgtaatcaac aaaaaccctc ctcagggatt cttcatctga tctgattata gtaaaaaatg 3201961 aagaatcgga caatcgtgca ttcgctccct ctacttacac catacccctt ttcagccaaa 3202021 atcaatcacc atatttgcat tttggtgccg gtcaaaactt attccatggt gccgctgttc 3202081 taatcagcgg cacttttttt attacatcat caagtccgcc gccagattcc gagaataaaa 3202141 gaaaataggc atacagtacc agtacggccg catttttcag gataatataa ccaacttaac 3202201 tattcatttt atttaggact ttctgcgttt gacagcattt tcctgaaaac ctacaattaa 3202261 atgatagtgt ttactatcat tttttaaaca caggctccgc aataaaaaga ctagagagaa 3202321 aaacaaaatg aatgaagaaa agaggggttt caaatatgta ttctgtttta tttcgccagg 3202381 cagaagagtc cagccagctg gctggagcaa aaggaatgaa tttgattaaa ttgaccaaac 3202441 acggtcttcc tgttccggac gggtttatta ttcaaacgaa tgcgctcgca cgttttatgg 3202501 aggacaacca gcttcaagag actagtgaaa acgtcgaagg cgggatcatt tccggaacat 3202561 tttcggatga gctgaaagat gagctgacta gttcctttta taagcttaga gaatcatatc 3202621 gatccgtagc cgtgcgttct tcgtctgctt cggaagattt agaaggcgcc tcattcgcgg 3202681 gtcaatatga aacctactta aatatcaaaa cagaggaaga gtttctggct aaagtgaaag 3202741 aatgctgggc ctcatttttt tctgggcggg tcagcagcta taagaaaaaa atgaacaatc 3202801 aaatcgcaga gccgttaatg ggaatagtcg ttcaggggct gatcgattca gaaatgtcag 3202861 gtgttatctt cagccgcaac cctgttaccc atgatgatag agagctttta atcagcgcca 3202921 gctacgggtt gggtgaagct gttgtttcag gaaatgttac cccagacacg ttcattgtta 3202981 ataaatcttc gtttgagatt cagaaagaaa taggtgcaaa ggaaatctac atggagtctg 3203041 cggcagaagg aattgctgaa aaagaaacga gtgaagacat gcgcagccgt ttttgcctta 3203101 cagatgaaca agtgattgaa ttggctgaaa tcacaaaaaa aaccgaagac ctgtacggat 3203161 atcctgttga tatagaattt ggaattgctg atcatcaaat ataccttctg caagctcgcc 3203221 cgattacaac cattgatcag gacaaaaaag cggcagaaga aaaacgcagc ttcatgatta 3203281 ccgacactga tatgaatgat ttctggctta acatggagtc taatattgaa ggtccggtga 3203341 gtccgttatt ttcatccttc atcgtgccgg cattggaata tggcttgaag aagagcatgc 3203401 aaaagtttcc gattggtgta gttgttgatg aagtaaaact ttatcgcgga catatttatt 3203461 ccaaaaacca aggcggacag cagcctcctt ctgaagactg cggcaaagag cttttcccga 3203521 ttttatcgga gcatatgtat gacatcatca atcacacata cctccctttt taccggacac 3203581 tggaccagct cgcacaaact gagcataccg cagaaagcgc actggaagct tttcaaaaac 3203641 taaaggcctt ttatctcacg gcttatgaag agcactttaa tatcgttttc ccgcaaatcc 3203701 ttttaacaaa caaactgcaa gcgatgtatc aggacattca aggagagtcc gaaaacgctc 3203761 atttttacga gatgctgaca ggaaaaatga acaaatcact ggaaacggac cgttgcttat 3203821 ggctattttc tgtggaagtt caggagaacc cgaaccttct ggccattttt gaaaacaaca 3203881 agcctgaaca gctccaggag aaattggaac aaacagatga gggaagacac ttcctgaaga 3203941 acgtccatga attcttgcaa gaatacggat ggagatctgt taaaagtcat gatctgattg 3204001 aacaaatctg ggtggaaaat ccgtatttcg ctctggccaa tattcaaaat tatgtccgta 3204061 atggctatca ttttgacaat gaatttcaga aaacaaaaga aaaacgagag aaattataca 3204121 atgaattctt ggaaagcata gaagatcccg gtttacgcac cgaatttgac cgctattatc 3204181 aatggacact gaactctgca aatataaaag atgatcacca cttttatatt gacgccatgc 3204241 tggatgccaa ggcgagaatc tttctgctga agataggtga attgctggcg gaaaacggtg 3204301 tcattcaaga tcgggaggac ctttggttct tatatgacga cgaagtggaa caagcgcttc 3204361 ttcaccctgt atccctgcaa gaaaaggctg aaaaacgcag acagattttt catgagtatg 3204421 agctggccca agccccggcc tacctcggca ccccgacaaa agaacagctc aaagcagctg 3204481 aagaaattgt cggcgctgtg atagaggatg aaaaaaacac agagaatcat atttttggca 3204541 ttgcggcatc aagcggcatt gcgacaggtc cggtgaaaat cattcgggac gccaatgaat 3204601 tttctcaatt cgcgcctgga gacgtactcg tttgcaagat gaccacaccg ctatggacca 3204661 gcctgtttca agacgccaaa gcgattatta cagacacagg cggcattttg tctcacgctg 3204721 cgattattgc ccgtgaatac ggcattccag ccgttctcgg cacacgcacg gcaaccgaaa 3204781 gactgcgaga cggtgacatc atcactgttg acggaagcag cggcaaaatc acagttgtca 3204841 gccggtcctg atgcgtcccc ctctttctta tacaagcggg gcgggtgtat acttgtcctg 3204901 ccagtatatt cgtgaggtga aacgtattga gaccgacaaa caagagaatc cttgatgctg 3204961 ccatgcagct gctcgtcaaa aaaggatatc gcgcaacgac tacaaaagaa attgcagaaa 3205021 aagcaaatgt aagtgaagcg acgattttca ggaactttaa aaacaaacaa ggactagttg 3205081 aggctttgct ttctcagcat tcttcaaaca gaggcagcat tttggaacaa acagaagggg 3205141 atttgtacaa agacctgctt catatcggaa cctgtctctt ggaggagctc gaacatagaa 3205201 aagatatcat taaaatcagc tttcgtgaac cggccatgtt tcaggatgtc attaaccacg 3205261 tcactgaata tccccaatct atgaaacagc tattggttga ttatctcaaa acgatgggtg 3205321 agaaaggggt tattcagaca ggaaatgaag cggaacatgc cgacgtgttc atgtcgatta 3205381 tcttcggtta tttcattcac cgtctccact taggagaccg ggtcatatca atgccccagg 3205441 aaaaaatgct ggagcatagc acagctctat ttgtcaaagg aatttctgct gattaactcc 3205501 ttggcataat aaaaaggagg atcccaatga gctcaagaaa agaatgggcg ctgatcgtct 3205561 cgctattatt gggggccatt ctggttccca ttaactcaac gatgatcgcg gtcgcgctct 3205621 catctatttc ccatacgtat aacgagtcca tcgcaagcat cacttgggtg gttaccgttt 3205681 atttaatcgt gatggcagtc acacagccga ttgcaggaaa gctcggtgac atgtacggca 3205741 ataaaacaat gtacttatgg ggagtcggcc tttttctaat cgcatctcta ggctgcgccc 3205801 tttcaccgag tctgctcctg ttaattgtct ttcgggcatt gcaggctgtc ggcggggcat 3205861 tgcttacgcc aaacagcatt gccattatcc ggcatgttgt ttctgaaaaa cgcctaccga 3205921 aagtgtttgg atttttcgga ctgggcgcgg gacttggtgc agcactcggg ccttttatcg 3205981 gctctatact gattgacagc ttcagctggc attcgatttt ttgggtcaac atcccgttcc 3206041 tcgccattgc tttatttacg gcattaacga tgtttcctca atataaagaa aataaatctg 3206101 acgcgccgct ggatatcatc ggctctctct tgcttgcagg cagcatcgtt tccattatcc 3206161 tgctgacgaa aaatgaggct ccatggggat atactgtata cagtgtattg atacttcttt 3206221 ttgttccgct ttttttcaga agagaaaaac gtacccagca ccccatcatt gactttgcac 3206281 tgtttaaaag ctcaaccttt acaaatgcga atctatcagt cttgttaagc aatttgatga 3206341 tgtatgccgt cttattgatt atgccgttat ttatgacgaa ccaatttggg cttaatacat 3206401 ctaacagcgg gatggcgctt tctgtatttt cgatcttcat gtcagccagc aactgggtgg 3206461 gcgcgcagct ccatcacaaa tggggagcca aaaaaatcat ttttctttca tttgccatga 3206521 tggctggtgc gaatctatta tttttgctgt taagcagctc gcattctgtc ttgttcctca 3206581 tgctctctct tatccttggc gggctcgctt ccggagtcgg tctgaccagc atgcaggttt 3206641 catcccttgc cacagtagac cccggtatgt caggagtggc atctgggatt ttctcgacct 3206701 tccgttattt cggaagcatc atttcatcag ccttaattgg cctgatttcg ggatatcaca 3206761 ccctatttat gattctcttt gctgtatcca tcatcggcgt ttttgtttca ttgggcatca 3206821 aatctgatga aacggcacgg atagaaaaaa actcagcgta acacaaaaca gcccggcatc 3206881 gcatcatcct gcggtgccgg gctgcctttt atgatcccga agcgactgct tcgtcttcac 3206941 ggtcatcctt tacgaagagg atgcccaatt catgatgttc tccttcataa gaagctcgct 3207001 ggtcaaaacg aatttctcca ttcaaaccga taatttcaag ctttacatat gcacggttat 3207061 gctgaagcgc ttcatagaaa tcagaaacgt tcttaaccgg tatgccattg actttcgtta 3207121 tgatttcccc gattttcaat tccagatcct cagccggcgt attggggata atcccaagca 3207181 ccattaagcc ctgatccctt ttcgagaaat aaaacggagc cgcgttatca ttcactcttt 3207241 gctttatgga cagaaaaata cgccctaaca aagcggtaca gaccgctgca cccgcaagcg 3207301 gcgtccacag taagctcgct gcaccgagaa ctgcgacggc aagaccgaga atacaaacgc 3207361 gtttcgctgt gatccttata ctcgtttcag gcagcgatcc ctgtaccctt tgtccaaatc 3207421 cgacaaagta aggaatccat agaaaatgga atgagccgcc gggaaccgta aacacgggcc 3207481 accagctaag gtgcgattct aaaccattac cgggcacgag aaggaacagc ggcaaaagcc 3207541 aaacccggtt tgccagctgc tgtccgatcg gcaaaccgcg gctgcttacg acaagtgccg 3207601 gtgatgttct cacatgcgca gaacgataag caaccgctcc ttcagtgata atcagcaaac 3207661 ctagaaacac agccacagcc ggccaaacaa ctgcaaatcc ttgcggaaat ctctccagaa 3207721 agggctccgc ctgatatatt tgcagtccaa aacctatcag catactcaca ctgacgatat 3207781 atgcagcaga catccagttt gcgcgaagag tgaacgctgc cgctgcagtg ataacggcaa 3207841 taatcgcaag taaaccgaga ggaatcgata ttccgagtcc acctaaaata actgacaaaa 3207901 gaagacctgg aatcagtccc tttgtatatg taaatttcag atcatcataa atatctgcta 3207961 ttcttgtatg aaaggttttt cgttcccgtt tgattcttac atagccgaaa gccaaggtta 3208021 tgatgataaa aaaccagaaa agcgggtgta agaagaacaa gcccgcgctt tttaacagtt 3208081 caattcccca ttgaacagac actatctctc accgcctcaa gccaaacatg ttactcatat 3208141 tctatcaaat attaaatggc ttggatatcc tcaggagagt ttatctctct tgcgtcatcc 3208201 acagcgtgac attcgatagt gaaaaatcct ttaaatagtg gtttacatcc acatccaata 3208261 acccgctgat tagatgcatc gaccttttta tatctgtcag attaattcct aatcgcttat 3208321 ggtttttcat taagtagtta aaataatgtt tggcgcattc ctcattaatg tcatttactg 3208381 attcgacatt ggtgtaattg accaaatatc tgctgaacag cataagaaga cttagtgctt 3208441 ttgtagctga aaatgttacg tcttgtgttc tgtcttttaa ttgttccact aattcataat 3208501 attttttttt cacgcacaat acttgccctc ttcaattgtg aacccccatt ttctttatac 3208561 agataagcac gggccagtat aagcagcagt actggagtgc taacaagcat tctcgctaac 3208621 gttactcttt aaatacctgt cgttcagctg ccattaacct gattactgtt ctttttagaa 3208681 ccttcttata ttgtatgaag taaacaaaga ctaggcaact tgcaaaagtt tcattttaaa 3208741 tgcatattaa ctcgttagaa agtctctctc atatattgat atcgggtaat aacagtcctt 3208801 tataaatgtt tatttgtgaa aattttttta atttcttgtc aaaaactcat tttttatgtg 3208861 acttatgatc cataatctct ttaagcacaa agaaacagga gatgaaatac catctccttt 3208921 aattgacaaa taatgatttc aatgctgttt gaagctgcaa atcatttttt tcatctgatt 3208981 ttttcttttc tatctgctga tttaatgtct ctgcagtgcg agtgtcgatc acaccggttt 3209041 tattcagctt gttttgatcc tgaaaagcca taaccgcttt tttcatgtct ttgctgaaat 3209101 agccatcctc acgtcccgga tcaaagctga gaccttttaa caatacctgc gcatgcttga 3209161 cgtcttcatt gttcatgtcc actttaagcg gctctttcag ctgtaagggc ccggcggaaa 3209221 aataatcggg ctgcttaatc gcaatggtcg gttcaattcc tttcttatga atccagtttc 3209281 catttggcgt cagccacttg taaagcgtta atttgatgtt gctgccgtcc cccattggca 3209341 cagcctgttg aaccgttccc tttccaaaag acgtatcgcc tacaacatca taatggccag 3209401 cttcctttaa tgcgccggca agaatttctg atgcagaggc acttccttta tccgtaatca 3209461 cattgacagg gtacgctttt ttatgggtca atgttgaaaa ataacgtttt ttatctccat 3209521 tgcgttcagc aatctgaata tacggctgat cctttgtaac gaaatgctta agaatttctt 3209581 ccacactttg aagatatcca cccgggttgc cgcgtacatc aatgacaagt ccttctattt 3209641 cttttttctc aagctccctc agcgcttttg caaaatcctc tgcggtgtgc tcagaaaaag 3209701 tagagatggc aatatatccg acagaatgcc cctgtacttt tttctctgat gcaaaaaccg 3209761 tttcgagcgg aatctcagct ctcttgatcc ggaatgacaa ctgcttcttc gttccaggcc 3209821 gctgaatctt cattgaaacg ctggaccctt tttttcctct tatttttaac acagcgtggt 3209881 ttaaatcctt gccggccatc gattctccat tgatgctgat aatttcatca ttaggcttca 3209941 acccggcttt ttccgctggc gatttcttga atggagaaac aataataatt ttgccgtctt 3210001 ccattccaac ctcagccccg atgccttcaa atgaggaatc aagagaatca gaaaattgct 3210061 tagctgtctg cttgtccatg taaacagaat aaggatcatt tagcgtagac agcattccct 3210121 ggatggctcc ctcgagcagc ttttctctat ctactttttc tacgtactca ttcgaaatta 3210181 actcatacgc tttttcgatt ttgtccatag ctttatcccg ttcagagtca gcttgtgccg 3210241 tcgcgggaac tgctgcagtc tggggcttat ccatctcaag caggttgatt cccgcatata 3210301 caccggcgcc tccgaacagc atgctccctg ctgctatcac agccattatt ttttgattca 3210361 tcctttactc ctcctgtatg ccagactgtc tttaccaaaa cctagagata gtatatgtaa 3210421 aggatggaga tttcatgtaa tcatagaaga aaaagaaggc aaatgaaaag ccgtcccgaa 3210481 aacggaacgg ctttttcact ttatactcgc agaaacttgc ggatggaagt cagacttccc 3210541 catactccaa ttactgcgcc gattgcaatc agcactagcg aaacttggaa tacaaatgga 3210601 ttataaggaa gaagagagac aaatgatcct tgaacctttg gaacgaccca tccgatgacg 3210661 tattggtaag tgctcagcac cagtgcaatc ggaatcacag aaccgaatac gcctagcagc 3210721 aatccttcaa ggaaaaacgg ccagcggata aaccagtttg tcgcgccgac aagcttcatg 3210781 atttcaattt cttttcttct tgcgaaaatt gtaattttaa tggtgttgga aattaagaac 3210841 atcgccgtaa ataccaggcc gataattaac gcgattccga tgttgcggga aacgccgacc 3210901 actttaaaca aacggctgac ctcttctttt ccataagtga ctttataaac atgatccatt 3210961 ttttcgatct ttttcgccac gttcggcgta tcatgcggat ctgtcgtttt gacgacaaac 3211021 gcatcattaa gcgggttttc ctgatccttc attgtcaggg attttccgct gtcaccaaaa 3211081 ctgtcaacca gctggtcaag ctctttttct ttagatgaaa aagtgacact ctgaatgccc 3211141 ttcagttcct taatatcgtt ctgaagcttg tcctgtgcct tctgatctgc agtcagatca 3211201 atcagcactt tgatttcgac ttgtttttct gcattcgtgg ccatgttatt caaattcagc 3211261 ataatcacta aaaacacgcc gactaaaatc agcgtaacgg ttacagcact aatggatgca 3211321 aatgtcatcc atgtgtttct cccgagagat ttaaaactct cacgcaagtg gcgcccgaga 3211381 attttaatca tatgaaccat actcccctct tgactcatca cgcacaatga taccatcttc 3211441 gattgcaatg acacgtttct tcatggtgtt tacgatttct ttattatgtg tcgccatcac 3211501 gactgttgtc ccgcggttgt taatttcctc cagcgtcttc atgacttccc aggacgtatc 3211561 cggatcaagg tttcctgtcg gttcatcagc aatgacaaca tcagggttgt tcacaattga 3211621 tctggcaata gatacacgct gctgctcccc gcctgaaagc tggtcaggaa attgtcgcgc 3211681 tttatgcttc agctgcacga gatcaagcac ttcaagcacc cgtttcttaa tgacagacgg 3211741 ctgttctcca atcacttcaa gggcaaatgc cacattttca aaaacagtaa gtttcggaag 3211801 aagcttgaaa tcctgaaaga caacacctat tttgcggcgc acgaaaggaa tctctttttc 3211861 tttaattgtc gcgagatctt tatgattgat taaaatttgt ccttttgtcg gtttttcttc 3211921 tctgtaaatc attttaataa aagtagattt acctgctccg ctcggaccaa caacatacac 3211981 aaactcgccg ggatgaatgg taacagaaat cccattgagt gcttttacgc cgttcggata 3212041 ggctttatat acttccttca tctctatcat gaaatcacct aatcttttat atcattttat 3212101 ctatcacacg gtcatactct tcgaatgcat tcgacaattt atgacccatt catttgtaaa 3212161 aagatgaaaa atctgaaagt tccctttttc aatacacttc attatacgtc aaatttagac 3212221 ataatactat tacagtttct tttcattcat attgtcaagg cataaaaaca tccttgccag 3212281 cactcggcaa ggatgttttt atcttacttt ttttctgaca gccatttggc aataacagcg 3212341 gcttcgttat catctacaag cccctttggc atattgccgc ggccgttttt aataatgctt 3212401 tcaattttgt gttcatcgta tttgcctccg acctcttgga gattaggccc tgacacacct 3212461 tctaaatcct tgccgtggca gcctacgcag ctttgctgat ataattcttc cccttcagat 3212521 gcagtggctt ccgtcttgct gccagtgtct gtcttctctt cttttgcatc gtttgatccg 3212581 caggcagcca acagaacaga aagcgcaaat ccaatcatta gtatcgataa ctttgatttc 3212641 atgttgagaa gcacaactcc tttacgatct cttccatatt ataacctcgt ttaagcgcgt 3212701 ttgaaaccct cgcccagcac ctcgctcgcg tctgctacaa ttacaaaagc tgactcatca 3212761 atctgtttga cgatttgttt caatttggtg aattcagttt gcccaaccac gcacattaaa 3212821 atcggacggt catcgtcagt atatccgccg actgcagaaa tttttgtcac gcctctgtca 3212881 atcttctgta agacagcctc cttgacagcc tgctcctgct ttgtaatgat gagcgccatt 3212941 tttgaacgat taaagccgac ttgcacaaca tcaatggttt tgctggacac atagacgcca 3213001 agcatggcat ataagccttg ctcaatatta aatacaatca tagccgtaac aacgatcatt 3213061 ccgtcaatga tggcgagaca cttccccaat gacagaccgg agtacttatg aatgatctgt 3213121 gcagccaagg ctgtacctcc cgtcgaacct ttccctaagt acacaatacc aattccgata 3213181 cctatcccga caccgccaaa aatcgccgcc aggagttcat gatgagtggc gggctgaata 3213241 tcccttgtca gaaacactac tagcggcaaa aacacagaac ctgcaagcgt ctttagtcca 3213301 aatttcccgc cgagcaaaat gacgccagca ataaataaag ggatattaat aatccactgt 3213361 acatacgctg cttcaaaacc atatgattgt aaaatcgtac tgatcccgct gaccccgccg 3213421 gcggcaatct tattcggaag caaaaataca ttaaaggaca cggccgtaat cgctgctcct 3213481 atcaatatgt atacataatc ccgcaaaatc cacaatgttt tattccgtac gtccatcata 3213541 tatcctccgt ttcttccaat gctctccgat agcattttaa tccttccctg attagatgta 3213601 aataacaccc aaatacagtg gtaatatgct aaagcagcag tgaaatcaag gatataagaa 3213661 ataaaaaaac acacccgtat gcatcaggtg tgtttttcag cttatgaaag cttagaacgc 3213721 aggtaggcat caataaacgt atcaatgtca ccatccatta cagcttgaac gttccccatt 3213781 tctgtattgg tccgatggtc ttttaccatg gaatacggat ggaatacata agaacggatt 3213841 tggctgcccc agccgatttc tttttgttca ccgcgaattt catccagctc tgcctgctgc 3213901 tcttcaattc tgcgctgata cagcttggcc ttcagcattt tcatggctct ttcacggttt 3213961 ttaatttgtg agcgctccgt ttggcatgtc acaactacgt tcgtcggcaa gtgagtaatc 3214021 cgaacggctg aatccgtcgt attgacgtgc tgtccgcccg cgccgcttgc acggtacgtg 3214081 tcaactttaa tatcctccgt acgaatatca atatcaattt catcgttaaa ttcaggcatg 3214141 acttcacatg aaacgaaaga tgtgtggcgg cggcctgatg aatcaaatgg tgagatccgc 3214201 acaagacgat gaacaccttt ttctgctttg agatacccgt aagcgttgtg tcctttgatg 3214261 agcaatgtca ctgacttgat tcccgcctcg tcacctggaa ggtaatcgag agtctctact 3214321 ttaaagccgc ggcgctctcc ccatcttgta tacattctaa gaagcataga gccccagtcc 3214381 tgtgactctg taccgccagc accagggtgc agttctaaaa tcgcgttatt tttatcatac 3214441 ggctcgctga gaagaagctg aagctcaaac tcattgaact cttttgttaa tgactttagt 3214501 tctttttcaa gctcaagctg gagatcagtg tccggctctt ctttcaaaag atcatgagtc 3214561 atttgtaatt cttcgtggga ttcattcaat tttttatacg aattgacata atcctttaaa 3214621 ccgtttgctt catttataac cgtttgagct ttttgctgat cattccagaa ttccggatca 3214681 gccatttgtt catctagctc agcaatgcgg gcctcctttg attcgaggtc aaagagaccc 3214741 cctaaagtcc gctaaacgag aagccatatt ttcgagctct gctctaattt ctgataattc 3214801 catttcattc acctcattaa aagatccgca ggcgcctgca ggcgccgcgg tcagtaaact 3214861 tgccggggcg aactattcag tacggccgca gcaattttta tattttttcc cgcttccgca 3214921 gtggcatggg gcatttcgtc cgatatcaac cactttgcga accggtgctt tctttgcttt 3214981 tttgttatcg tcgccttctt gcggctgatg agctgttgtt tgaccttgta caacctcttc 3215041 acgctccaga ttgttttcaa tctcagcttt catcacaaat tttgcgactt cgtcctcaat 3215101 tgattcaatc atatgctcaa acatcgcaaa accttccatt tgatactcac gaagcgggtt 3215161 cgtctgcgcg taagcacgaa ggtgaatccc ttggcggagc tgatccatcg catcaatatg 3215221 atccatccat ttagaatcaa cggcacgaag aacgataact ttttcgaatt cgcgcatttg 3215281 ctctttgccg aattgctctt ccttctcatt atattttgtg atgatgcgat ccataatgag 3215341 ctcaagcatt tcatccggtt ctttgccgaa gatatcgctc ttctcaagtg caccttcatc 3215401 aagataagtt gtgttgataa gatcaactag accgtcaagc ttccactcct caggaagctc 3215461 ttctcttggc gtataggctg caattgcgcg ttcgagagaa gacttgatca tattttcaac 3215521 gatttcacgc aggttttcag agtcaatgac ttcaaagcgc tgcttataaa tgacctcacg 3215581 ctgctggcgg agaacatcat catattgcag aagctgttta cgcgaatcga agttattgcc 3215641 ttcgacgcgt ttttgagacg attcaaccgc gcgagatacc attttgcttt ggattggagt 3215701 agagtcgtcc atgccgaagc ggtcaagcat cgccattgtc cgctcagctc cgaatctgcg 3215761 catcaattca tcttccatag aaagataaaa ttgagtaatc cccgggtctc cctgacgtcc 3215821 ggaacgacct cgaagctgat tgtcaatccg gcgtgattca tgtcgttctg ttccgactac 3215881 agcgagcccg ccaagctctt ttacaccttc gccaagctta atgtccgttc cgcgccccgc 3215941 catgttagtc gcaatcgtaa ctgcgccttt ttggccggcc tcttcaatga tctgcgcttc 3216001 acgttcatgg tttttggcat ttaacacttg atgcggaatt cctttgtttt taagcagctt 3216061 agaaatcaat tcagatgttt caacggcaac cgtaccgact agaacaggct gtcccgtcat 3216121 gtaacgctgt gcgacatcct ccgcaactgc cttaaacttt ccttccatcg tgcggtaaat 3216181 taaatccggg cggtcatcac ggacaacagg cctgttggta gggatcgtga caacctgcat 3216241 gttgtagatg ttgcggaatt cttcttcctc tgtcttagct gtacccgtca taccggcaag 3216301 tttttcgtac attcggaagt agttttggaa cgtaatcgtc gccaaggtca tgctttcgtt 3216361 ttgaatctca agcccttcct ttgcttcaat cgcttggtga agcccctcac tgtagcggcg 3216421 gcctttcatc agacgtcccg tgaaggaatc aacaataaca acctgtccgt cttccactac 3216481 atagtcaacg tccttttgca tcgcaacgtg agcttttaag gcctggttga tatggtggtt 3216541 gagcgcgaca tgcttcacat caaagaggtt atcgatgccg aatgcttttt ccgccttcgt 3216601 cattccttct tcagtaagct gtacagcttt tgttttgata tcgtacgtgt aatccttctc 3216661 cgcttttaac gtgcggacaa aagcatttgc ctgtacgtac agcttagtgg attttgcagc 3216721 ttgtccagaa atgataagcg gtgttcttgc ttcatcaatt aaaatagagt caacttcatc 3216781 tattaccgca aaatgaagcg ggcgctgaac catctgctct ttataaagaa ccatattgtc 3216841 acgcaaatag tcgaagccaa gctcgttgtt tgtggagtaa gtaatatcag cggcataagc 3216901 ttcccgtttt tcgtcttttg acattgagtt taaattcaaa ccgacagtca aaccgagaaa 3216961 ctcgaaaatt ttccccattt gctcagcgtc acggcttgcc aagtattcgt tgacagtcac 3217021 gacgtgtacg cctttaccgg ttaacgcatt taaataaaca ggcagggtag acgttaatgt 3217081 tttcccttcc cctgttttca tttccgctat atttccgtca tgaagcgcca cgccccccat 3217141 gagctggact ttaaacggaa acatgcctgt tacgcggcgt gaagcttctc gaacaacagc 3217201 gaaagcttca acaagaagat catccgttgt cgcccctttt tcaagacgct ctttaaattc 3217261 aattgtttta tgtttcaatg cgtcgtcaga gagattttca tagtctccgc gaatcgcatc 3217321 aatatcgtta gcaatttttt cgtatctatt cagcgtacgt tttgttggat caaacatttt 3217381 atttaaaatt ccaagcattt ataacgctcc tctatcatca cacgcctatt ttagaggcat 3217441 gtataaataa tttactagtc catgtatacc tctcattatc atatcatacc ttttgttatt 3217501 tccaaagaat ttgcaaataa gaaaaacaaa aaccttccgc ggacatcacg gaaggcttct 3217561 cttcattatt cagtcggttc aattaagcca tatttcccgt catttctgcg gtacacgaca 3217621 tttgtaaggt ttgtttccgc atttgtgaaa acaaagaaat tatggccgag catattcatt 3217681 tgcaagatcg cttcttcact atccatcggc tttaaattaa agcgtttctg acggacgatg 3217741 tccaagctct cctcctcttc tatgtcatcc tgaaccgcaa tatctgtatc agagccaaga 3217801 ccgtttgcca ataaatattt tggagagccc tgctcacgga atttacggtt tactttcgtt 3217861 ttatgcttac ggatttgacg ttccagtttg tttgttgcga gatcaattgc gttgtacata 3217921 tcctcgttat gcacctcgga ccgaagcgcc agatctgtca tcggaatcgt aacctcaacc 3217981 ttagactcct tgtcattgta aaacttcaag ttgacgttca catcagcatc cacgctatgg 3218041 tcaaaatagc gctccagctt gccgatcttc ctctcgacat gatcctttaa cgcgggtgtc 3218101 acttcaatat tttctcctct gatgttatag ttcatcaaag aacgcctccc ttttattaag 3218161 gatatgtatc tatttctctt ttacccttta caattcctgc tgaaacataa atcttttgtg 3218221 aaaattcagt gaactttgtc gaattttgtt tgtatttgct ctgttattgg cggttcggag 3218281 gtatatgtat atgctgattg aacgaaacaa atacctcaca cacgcctaat tgattaaaaa 3218341 gggttccata cattgatgaa tagacagcat ccattttcta taatgaatca gaaaatgttc 3218401 ctttaaatac tcacagaact catgagaggg aaaagagaaa gagaccaatt gatcaaactc 3218461 cgcaaaaatt tggtcaaatg ctttcacaca aatttcagca caccgcgaat ccataatgaa 3218521 gagaagtgtt gaatgtgttg aatccaaata aaaaaaggct tggatcagat cttggtagat 3218581 ccgatcccct tctgtttttg ataaattctc ttcagcctct atcaaataac acaacccctc 3218641 ttcgatggta aaaagaagat gataataagc tgataaaagc gtataatctt caatgctctt 3218701 caaggcactc acctatttac gcttgtcata atatgtgccg tcaatcgtaa tgttgttata 3218761 agggtttaaa tacgtcgtat gcatcacacg ttttcttttc atctgctgaa gttctgttgc 3218821 gattgactgc ttcagtcttt ccatttcctt cacaatcagc tgatcccatg tcaaaataag 3218881 tttcatctgc tttcgctctt cttctgaaag cggcagagat atctcctgaa tcagttcaga 3218941 ccgtgtagcc acaaagtctt caatttgctt taaaagttca tcgctttccg gcgtattttg 3219001 tatgtgtgac agcatactct tcgtctcagt gtatagttga tctatattat tcatgcgatc 3219061 ccgcctgatc cgtgccggtc cttccgctca ctttgaatgg cttgtttcca agcatcgcga 3219121 aaatctgtta cataaccttc aacctcagcc agcatgcccg tatcattttt gatatttgcc 3219181 tgtaccaatc tgcgatacat ataatcgtac atcgcaccca tagaagcgga aagctctatg 3219241 ttacggttaa gtgtaaaatt taattcctga ataatatttt gcgctttaat cagattttca 3219301 tttttacgtt ccatatcatc attctcaatg gcctgagcgg caagtcttat aaatttcaaa 3219361 cagccattat acagcataag cgtcagctcc ccgggtgtag ccgtattcac tgaattttgc 3219421 tgataggctg tatatggatt ttggatcgcc atgtgtcatc ctccaaatta catttattgt 3219481 acaagaagct gtgataaata ggacgcttgt tcgttcattt tttgaatcgc agaatccatt 3219541 gcactgaatt ttgaataata gcggttttct atggtattca atctgtcctg catatcagtt 3219601 atttcagtac ttatcgagtt taaatttttt ccaatggaat agctactagc tcccattgtc 3219661 gagttcccag ctttagcttc aatacttttc acagtacttc taagtgtatt agtaatccgc 3219721 ttcataatac ctttatcgct atagttacta tcatttgttc cacttgtaaa aagattagca 3219781 actccttgag gatcttctgc tatttttgct ttcaatttct cttcgttaat ctctaagtgc 3219841 cctcgcagtt ggtaagcact tgaagttgtg atgccaaatt cagttaattg ataggttttc 3219901 ccatccgcat tcacttgagt ataaaagtca gtccgcattt ggttcgtgcc agtgctgatg 3219961 cttgaatcgt ttctcagcaa tccgcttttc gccttctcct cccagagctc tacctcttta 3220021 tcggacatgg cttctttttg ttcactcgtg agtggcgtat agtctcggta tttttcttct 3220081 ttcagctttt cattcaggct gtcaaccagt tcattgtatt tatctacaaa ctctttgatt 3220141 tggttataaa tcccatcaac atcagtagaa acagatgtgg taacagggcc tgtggctgca 3220201 gttgtatttt taatcgaata agtaacacca ttcaccgtga aattgtttgt cagcttctcc 3220261 atttcaaagc cgttgattgt gactttggca tttgtgcctt ctttgtaagc agtaagctta 3220321 ttatcagcat ccaaagaaaa accaagctga ccggacataa agtcagctgt agcagagtct 3220381 gctgcctgta tgcttcctcc tgcacctgtt gctttagaag aaaacgcaat cgtttctacg 3220441 tactctgtac cattccaaat tttatcttta aatgctgata ctcctagatc tgagctgtta 3220501 agtttagaaa tcacattatc aatcgtatcg gcactcgtca cactaatgtt cactgttttt 3220561 gctgttgttt cgccaggcgc aacaacgtta aatgccaaat tgtaatcgcc ttgtgtgtat 3220621 cccgtataat tgtttgcctt atacgttgct gcagttgcca agctcgccac ttcaacagta 3220681 gacgaagaat ttggcgcact tacgcttcct gtagcagtta acacagactc attagagctt 3220741 gtcacagttt tgctctgata cgtgctcgga tatgtcaacg tatttttaga catataatct 3220801 tgcaattctt ttatttttga gtttacttca cgatagctgt cacgctgcca ttcaagagtc 3220861 tgcttttttt gtgtcagctt atcaagcggc gctctttctg tctgcatcag ctttgatacg 3220921 atatcatcta tatccattcc tgacgccaga cctgttattc ttgtgaccat ctcaaaccac 3220981 tcctattcta ctttttttca tctacaaata acccaagaaa ttcagtcata gccgcataaa 3221041 aatcaagcca ccgttttggt ggaatttcgc ggatcacttc atttgtagag tcctctatta 3221101 cctttacata gtattcattt aacttgtcat gaagctcgaa cttcagatga acttgcgaag 3221161 gttccaaaag cttgttcatt tcccccacca tttcagcaag attggtatat gaaacttgat 3221221 gaacaggaac ctcgttatca ttatctttct gattatgtat ttgagtatca taacgatccc 3221281 aaacaggttg taacgtagtg agcctttcaa tgttcaattg atcatcccct atgccccaat 3221341 ctatcgttta tatcgactaa gtcgagataa gattacacat atttttggaa aaaaatcttc 3221401 tgttttagat ttcttgtatg gaaatacatt tataaaaagt tagtggagaa tccggttatt 3221461 atatcatgag ttagtgacag gatgaggaat gattaggaga tagaaattta aattaaaaga 3221521 ccctggcaac gccaaggtct tttttaaaat taacgtaata attgaagtac gttttgcggc 3221581 tgttggtttg cttgagcaag catagcttga gaagcctgag aaagaatgtt gttctttgtg 3221641 aattcgctca tctctttagc catgtcaacg tcacggatac gagactcagc agctgtcaag 3221701 ttttcaccag aagcgcttaa gttgttaatt gtgtgctcta gacgattttg taccgcacca 3221761 agcttagcac gttgagaaga aacttggttg atcgcttcat caacaacttt caattgagca 3221821 tcgaaaccga tatcagcagt atctgctgca ttatctgcga attttgttac gtcaagatca 3221881 ttaactgaat gaagagctgc aattgaacca tcagcttctt taattccaag agcgtcagca 3221941 cccatatcct caatatttac agagatttgc tgtgtagcat ttgctccgat ttggaatacc 3222001 aagttctttt gatttgcagg agtagctgtg tcaactttgt aagtgccatc gagcaatttc 3222061 ttaccattga attctgtacg atttgaaata ccatcgattt catctgttaa agctgaaatt 3222121 tcatcttgaa tagattgcaa atcagttgct ttgtcctgag ttccagtgtt tccagcttga 3222181 acaactagct cacgaacacg ttgaaggatc gcatgagttt cagttaatgc accctcagct 3222241 gtttggataa gagagattcc gtcttgagag tttttagaag ccatttcaag acctctgatt 3222301 tgtcctctca ttttttcaga gatcgcaaga cctgctgcgt catctcccgc acggttgatg 3222361 cgaagacctg aagaaagttt ctccatgttc ttttggctcg cactgttgtt tgaagacaaa 3222421 cggttcagtg tgttaagcgc tgcaatattg tggttaattc tcattgtttt gttcctccct 3222481 gaatatgttg ttaaggcacg tccttgtgcc cttattttgt aactggctga gtcttttgcg 3222541 cctcctcccg gctacatcat taatatcgga ttgtctctga ttttgttaat acaaaaataa 3222601 aaaaatcctc actttttttg tgaggataat gcggagatca catcgctgga taacgctgct 3222661 gcacggttat tttcttcctg aatggtcaag taaatttctt tcctgtgaat atcaatatgc 3222721 tttggggcgt caattccaag cttcacttga tccccttcaa ccgcaatcac ttttacttca 3222781 atatcagcac ctatttgaat cgcttcgttt attttccgcg ataaaactag catgattctc 3222841 ctccaatcgg atgctttgtc gtatatgagg agtcgtgtaa aacgacttgc ttagccatca 3222901 tgttcttgcg attcacaata atgggagcca ataaattcgc agtagacttt tcaaatggct 3222961 ctgccatagt caatattgtc atgacttcta cgtcttgaat attatcgata tccaaaagtt 3223021 cagcagttga ttcatcaaga tcaaattcat aattcttaaa aaagataaac ggacttacga 3223081 cgataaacgc aagattttct gaagtgacgg actgcagtgc cacgaatgga gagtcttctg 3223141 aaagcggaag tatgacgaac tgtttttctt ctaaaaagcc tggaatcccg ctttcaaaaa 3223201 gaatgatttg ttcttctttt atgttcattt ggccatggta cttcgtatga atgatcattg 3223261 ttcacgatcc ttttcttttt acttttcggg tgattctttc gggtattcta catctatatt 3223321 taaatcaggg tattgaagca tgtcaacctt aacatttcct ggcgtatatt caacaattgg 3223381 cttatgcggc tcagcctgaa taacaggctt tcgcggcgta atctgcacat caagctgtga 3223441 cggagtatat tgtattttca ccctcgaaag agaaggagca taattttcgc ctaattgaat 3223501 ttggtgcatt tcagagttcc tccttgcttg tgaagcgatt gggttcccct tattttcaat 3223561 cttcataagc tcgtcgcctt cttctgcagt gcgtgctatt ccctccatta catcctcatg 3223621 cccttgttgg gcggcttctt caattctctt gaaaacatgc tttctgtcta attcttccca 3223681 tgcttgtgtc tggtcaatcg tgagttttcc aggtgtcacc gatatttcca tttccgcact 3223741 cggctgttcg atctctagat cagcttgagg ctgctccatt tttaagctgg caggcgtcgt 3223801 tgttaaacca atttttcctt gaacactatg cataatcaat ctgggaatct gcatcactct 3223861 acctcctgaa ctataaaaaa agcgaactcc taagagccgc ttactttaaa aagtcaatca 3223921 atgtaggctg aacaatttgc gcattaacgg ccagagtagc cctgtgcaca ctttgctgcg 3223981 caataaattc agttattact tcttccagtt ctacatcttc attgtctgat aacactttgg 3224041 tagctgtttc ttcttgcgct gacagtcttg tattaaccag ttcaagacga ttatatctcg 3224101 ctccaagatc agatcgttca gcgctcatgc cgtcagaaaa atgatcaata tcatttaaaa 3224161 cactgtccat gccatctagc gaaccagaat ttagtgcttt ctcaaaagaa tcaagcattt 3224221 caaatacatt ctgcccgctt tcagaagtgc ctccaaaagc tgactttgga tctgaattca 3224281 ctttcaatga catattattt gatatattga ctacgacatc agctgtatca gaaattgtat 3224341 aagttccgtc tccgttatct gtaaccggag gcttatctga atttgtgcca ttaaagatat 3224401 atctgccgtt cacttgtgta ttcgcaatat ttaaaagctg ttcctttaac tgctttacct 3224461 ctacgccaat cgcttgccgc tccggctcgc cgtttgtatc attttgagct tcaaccgcta 3224521 attctctgac ctttgacaag atgtcaattc cttctgtaat gtttgtttct gtgttttcga 3224581 gccaggtaaa ggcttgagaa gcattgcttt tgtactgctg cacttgagac agttgcgtat 3224641 tatactttaa gcttttcatt gctactacag gatcgtcgga agcttttgag attttttttc 3224701 ctgaagaaat ctgcgactgg agtttatcca gcttcgagta gcttgaaccg atatatctca 3224761 gtgagttttg ctgtatcatg ccttgtgtta ctctcatgtg actctaccta ccttcctcca 3224821 acacccatgc cgttgatcac tttatcaagc aattcgtctt gtaaagtcac cattcttgca 3224881 gctgcattgt atgcgtgttg gaattgaatc atattcgtca tttcttcgtc taaagaaact 3224941 gcgctcattt gctgacggtt tatgtcagca tcattcagct gtgtttctgt attagacgcc 3225001 agtcgattag cctcttgagc ttcgatccct agctcgccaa tcagacccgc ataataatct 3225061 aaaacactag tttctttacc gttaatggtt attttaccgg ttaaaacatt tgctaatttt 3225121 gtagcatttg cgttatcgtt ggctgcgcca gtcagtgaga aagcaatgtt tgcgcctttt 3225181 gaatctatta tgctgtcagc cactttgatc ttgcccgccg cgcccttggc aggttcagtt 3225241 tcaccgccag taaaatcaaa aaagtctccg ccttgttcac cgctcttggt cacaccattt 3225301 ctgtgcactt cattgaaagc tttcgcgaat tcaagcgcca tattgtcaag atcagaaagc 3225361 atttccgggt atacgccctt ttcttggcca tctgctgtta tatacccata agactctata 3225421 aaccctaaaa gggatccctt gctgctaaag gactccgcct gtacagctgt atccccgatt 3225481 gaaatacttg atactaaccc agtttcatta tcatagttgg ctgcaagttc tgaaacctcg 3225541 taatttttac cgtccaaaac agttcctagc gactgtttat ttttatcaag gatttcaatt 3225601 gatacagttc cttcagcaga tgcaagtgca ttcccgcctg atttgttgta gctgactttg 3225661 atatcaacca ttgaggataa tttatcgatc agcaaatctc gctggtcata taagccattc 3225721 ggaagaagcc cgaccggctc tacttgtgca atttgcttat ttaaactgtt taactgagaa 3225781 agcagagaat tgacatccaa cacagttgta tttagctctg cttttaaatt cgattggaca 3225841 tttgtaagtg attcagaaat ataattaaac gtttcagcta cagcttgtcc ttttcgagca 3225901 acaacagaac gtgcactttc ttcatttgta ttattcgata attcctgcag ggaattccaa 3225961 aacgaattga gcacactgtt caagccgctg tcatccgttt catttaaaac gccttccatt 3226021 tgggacagcg cttttgcctt cgtgtcatag tatccggcac tgttgttttg aagacggtat 3226081 tggtagtcaa gaaagatatc tcttattctc tcaactgatt ttccttgaac gcccgtaccc 3226141 atttgtcccg ctgttttttc tgcattttta gatacagcag ggaaatagtc agttgcctcc 3226201 aatgagaccc gctgtcttgt ataaccatca gtattggcat ttgccacgtt atttgcagta 3226261 gtgcttaacg ctgcctgctg agcgcttaac gcccgccttg cagtttcaag ccccataaag 3226321 gtagatgtca ttttctgaat tcctttctgc taagcttttg aatcaaacag tttcattttg 3226381 ctacttttcg gcagctcagc tttaattgat ttgctgtaat tgaagttatt ttccttagga 3226441 accagcatat cgtacgaaat agagatgaat tgcagcgcgt ctcttgtcag ctgcctattc 3226501 atctcattta cttttttcag acgtccgaga acttgagaaa gagattcgta tagttgttcc 3226561 agctcttcct tttcactgcc tgaggttttg gcgatacatg cggaaatagt attattttcg 3226621 ctatatccga gaaaggccga agttgttttg atccggtcat cttctgtctg cgtgattgct 3226681 tgaatatatt tttgctcttt tgtcaaaatg ttagaaagct cttttgtttt gccggctttg 3226741 agcgcttccg tcttttcttc agacagcgtg agcaggtgct catgcagaac gcaaagtcgc 3226801 ttcaattgtt caataattgc cttcgctgac atgggctttc tcctttttta ttgcttttta 3226861 taaaaattaa tcatattttt cgcaatatga tttgcgtcta ctttgtatga cccgttttca 3226921 atttgcgctt taagctgcgc aattttttcc tgtcgtgaac cagtgactgc gtcggatgca 3226981 tgttgcattt ctttagcctg tgatgaaatt tcaattttat cttgaggttg tgcaacagtt 3227041 ttttgcaccg cttgcttatc ataatttttt tgatatggat taacggattg tgttccaaat 3227101 tgattgattt tcataggatt cctctcgctt tccgttgcag tctttaaaca atcttaaccc 3227161 ttttatcgac tgcgttttca gttagtttag ggaatcagct gtttttggta ttataggcat 3227221 agtatgtgtc ttttttacta ttttctttct cgattttcag agcatcctcg tggttcaaat 3227281 gatccatttg atccttaata tcagactggc aagccttgca gaacttgcct tctctaatcg 3227341 atgtcccgca cctttcacaa gggtatgcca aattaggaag atgagtgatc tgaattcgct 3227401 tctgcctgat gaatttcaat atcagctctt cttccacacc tgtttcctca gttatccggc 3227461 tcaaagttga ttgccggttt tcctgttttc ttaaaaattt atagacagtc tcaaatgatt 3227521 tttcttcttc cttaatacac gcctgacata cggtttgcag ctttgttttt aaaaataaag 3227581 cattgcattt cggacaatta gccagttctc ccatcttttt ttctccttat tagataatat 3227641 gcctgtgtca atttctagtg attatatcgg cataaaaaca gaatcattta gcttctgatc 3227701 aaggtaaaag atgacactga agcggctttt cctttttcta ataagcagcg ggctgcgaag 3227761 tgcaaggtgg cgcctgttgt ataaagatcg tctattaaaa tgatattcat accttctgct 3227821 gaattatttt ttgtatcaaa aatgcactct gacagcaggc gttctgtttt ctttttcttt 3227881 gactgtttct cattattcag gcgaatgagg ggatggtggg aaggccggtc taaacattct 3227941 gccaagagat gtgcctggtt aaatccgcgc tcttcttccc gttccttgct cagcggaata 3228001 ggtacaagaa caaaatgctt atcggggtaa accttagaaa aggttgaaga aaaatcactt 3228061 ttaaatgcat ttatgatttc tgcatctcct ctaaatttaa aacgggagag cgtttctttc 3228121 atcatatcat tatatgtgta aactgaacgg ttttgacgca atagcaaact gtctctgatc 3228181 cttgttctcc acacctcgca atccctgcat acggcatgaa cagattgagg tctgccgcac 3228241 agggggcaga tatgtcctgt gattttcttt aatttgcttc tgcaagaata acaaaccttt 3228301 tcatcaggct ttagtaaaaa aagggctctc catgtaacat cttgagaaaa ttgcgaatca 3228361 cataataaac agatcagttt atgaatgcct cctcctgctt cgtttgacat aaatcgcttg 3228421 gactctctga aactactgca gcagattcag ccaaaatgac aagcattgct gtgttttttt 3228481 gtttatctac cagctcagct ttcgtatatg cgatcttttt aaaatcagta acgtaggatg 3228541 gactcacttt gtttaaagaa agtgccaata catcgttttg gcatacttgg caagtacagg 3228601 ccatatgaag ctggtccata tatcggtcga gcagttcttt cattacgatt tcttttgaat 3228661 tgacaagcat ttttacagct cctcatcatc ggttatatga gtatactgta ccacgttttc 3228721 aaataatggc tagtctgtac attcaacttt tgctgccaat tcattcattt cttttatatg 3228781 ctttcttgca tcgagcatac tctttgtttt gccgaagtga aagtaaatga catcgccgtc 3228841 cgcatattct ttatgccggc cggttcttcc tgcaatttga acaagtgcgc tttccgtaaa 3228901 gatagacgat tccgctccta gtacacccgt ttgcaccttg gggactgtga cgcctctttc 3228961 cagtattgtt gttgtgatta atagatcgag ctgaccatct ctgaattgct gcactttctc 3229021 ctttctatgc ttgtcttccg cgtgcacaga tgcggttcgg caatgaacac ctttaaagca 3229081 cgcagcagcc ttttccagaa tagaaacgga aggaacgaat aaaaaaacag gcctcccttc 3229141 ttttacatga aactctatcc atcttttcac cgctggcgga attttatttc ggtttaattt 3229201 cttcttccag tttccacacc atacaaagcg cggttcgggt aaaggtttcc ggtggtgtct 3229261 tgcggggatg cgaactgaat gtaactgtcc gttcagtgct tttcttttta attctttagg 3229321 aggtgttgca cttaaataaa cgagggtgct gtttttcttt cttgcttttt gaacagcgaa 3229381 ttgaagggtt tgatcagcag aatatggaaa agcgtcaact tcatcaatga tcataacatc 3229441 gattgcatct ttatatcgca aaagctgatg cgtagtggaa atcataagcg gagatagccg 3229501 ccctttgtca tcgcttcctc cgtaaagcgc tgaaatgtca gcaccctgaa aggcagcctt 3229561 gagtcttgga gcaagctcta atacaacatc ggtgcgaggt gttgcaatac atacacgcag 3229621 tccttgattt aacgctgatt ctataccagg aaacagcatt tctgttttgc cagcgccgca 3229681 aaccgcccag atgaggagct cttctttttt tgatattgct tcaattaaaa cattggcggc 3229741 tttttgctgt ccgcttgaaa gcttgccatc ccatgtcagc ttaatagact tccagtttga 3229801 ttcattttcc tctttccatg aatataaagg aacctcctca ctcactctgc ccatcatgac 3229861 acaggaacgg caatacagct tattctttcc agatgagtga taaaaagaaa aataccgctg 3229921 atcagtttgt ccgcacctat tacatctata tctccgttta tttatggata tagaattttc 3229981 agcagtgata tatccattct tgatatgcca ttcaatcatc tcatcggaaa atgagagctc 3230041 agtcctgagc aaatgacggc ttcgaagcgt ctgctgcaat tcttttgaaa aggaactgtt 3230101 tttttcaact ggcacattca catagcacgc ctcctttcga aacagtatgc ctgaatgaat 3230161 attttctgtc caactattaa aataagaata taaaaaaatc tccgctctaa aaacggagat 3230221 ttggccttat ttaaaacacc agcaaattcc taacgcacct tcacccaaat gagtgccgat 3230281 taccgcgcca aaatagctgt tataaaattc aacatgagga tattttgcag aaagctcttc 3230341 aatgattttc gctgcttctt cctctcgatt agcgtggata acagcagctc gcataggcaa 3230401 ccctttactc gcatcttcgt ctaaaagctc ataaattcgc gaaattgctt ttttacgtgt 3230461 gcgaatcttc tcaaaaggca caattacctt attgtcaaaa tgaaggatag gctttacctt 3230521 tagaagacta ccaatgaagg cttgggcgct gcttaatcgc ccgccgcgct gaagatgggc 3230581 taagtcatct accataaaat aagctcgaac tgtttttttc atttcttcca gttcttttat 3230641 aatatcttcc ggcgatgatg ctccgttttt gattaattca gcagctttaa gggcataaaa 3230701 gccttgagcc aagcagctga tctctgagtc aaatggatac acatcaatat tgtcgaccat 3230761 cgaatcagcc gctgctgcac tgctgaatgt tccgctgatc ccgctggaaa gatggatact 3230821 gataaccgca tcataagact tgccaagctc ttcatacaac gcaaccagct cgccgattgg 3230881 cggctgagaa gtcgtcggga gctcattatg ttttttcact tcttcataaa agcttttcca 3230941 gtccaactca atttcttcac ggtaagtctc ctccctaaaa acaacctgga gagggatcat 3231001 atgtatctga tgttgttcac gcatttcttt cggaatatat gccgtgctgt ctgttacgac 3231061 tgcaatattc atagcttcga tacctgcctt attgctttat aactctattg taagggaaac 3231121 ggcagcctaa aaaaagacct gcctagtaaa aggcaagtct cctattatac tatctcattt 3231181 ctacccagcc atttttaatg gcgaccacaa cggcttgcgt ccggtcgttt acattcattt 3231241 tttgtaaaat attgctgaca tggtttttaa cggttttctc actgataaac aatgattcac 3231301 caataccgcg gttgcttttt ccgtctgcaa gcatctgcag cacttcacat tcccgcctag 3231361 ttaaaatatg taatggtctg cggatttcag ggtaaacctc atgttgaggg tgtgcagaaa 3231421 ctccgcttgt tgcaaggcgg cggaattcgt taacgaggtt gtgagtaacc ttcggatgga 3231481 ggtaagatcc gccctcagcc actactttaa ccgcttcaat taatgtatca gcatccatct 3231541 ctttcagcag ataacctctt gcacctgttt tcagggcatg tgttacataa ttttcgtcat 3231601 cgtgaattga tagaataatt actttagatt caggatacag ctctacaagc tgttttgtag 3231661 cttccacacc atttacgttt ggcatattga tatccatgat cacaacatca ggatgatagt 3231721 gctcaacaat acgagccgct tcgtccccgt catcaccttc ggctaccact tcaaaggtag 3231781 gttcaaaatc caatatccgt ttaacacctt cacgaaataa ctgatggtcg tcgataataa 3231841 caatgtttac tttagtcaca agccacgcct ccttgtatta ttgttctata tactctagca 3231901 ttcggtcaat atgccttttg gctctatttt acaaatcata gtcaaagaga taacggaacc 3231961 ttaatcataa taaatgtccc aagacctatt ttcgaatcta ttgtcatcgt tccttccaat 3232021 aaatctactc tttctttcat gcccagcaag ccgaatgatt tgtttttctt ctctttcgct 3232081 tccttcaggt cgaacccttt accgttatct tttatcatta aaatcacaaa atcctttgtg 3232141 atctcaactt tgactgtaat ttcttcagat tcagaatgct ttagcgcatt agacacagct 3232201 tcctgtgcga gcctgaagag cgcaacctca aactgaggcg ctagcctctg atcctctgtt 3232261 tctccaatgc actgaaaatg tattttgacc ttcccgttat attcctcggt tgtatataga 3232321 tattttctta aagttggaat caggcctagg tcatcaaggg ccatcggtct taaatcatat 3232381 ataatccttc tcacttcgta aagggcattc cgaacatttt ggcggagatt tttaatttct 3232441 tggaatccgt cctctgcgcc ccggtcacgg aaaatccgct cgattaattc cgatctcatc 3232501 ataacattcg ccagcatttg agcgggtccg tcatggattt ctcttgagac tctttttcgc 3232561 tcttcttcct gcgcctcaat aattcttaag ccgaaatcct gttttgcctg agcatcagca 3232621 agaagcagtc caacttcgcg caaatcctga ttcaagtagt tgagcacaac tgtaatttgg 3232681 cttactaatg attctgaccg ctcaatgatt tcctgaagcc ctagcaatct gcgctccaaa 3232741 tcgtcccgcc gttcgcgcaa ttgcttctca cgctgctgga tcatcgtcaa ttctacctgc 3232801 agcttatggg ctttttcata agcattgcgg atttcctctt cactgaatct atgaaaatta 3232861 cggctgacct cggataaacg gtttctcgca tggcgagttt gcacttcaag tttatcgcca 3232921 agctcaatca cttcatacac ctgctgttta atttgtttca gttcttcgac cagctgttca 3232981 tactgctggc gtgactgctc cccgatttga aaaacctcgt ccttgctccc gtcaacggtt 3233041 ttcagcatct tcatcaaaat agaatccagc actttggaat ccatctttgt tttattcata 3233101 atttccctcc gtcacggcgt tgtcatatat ttttattata aatgtaattg atctgcaaat 3233161 tatgtcgaat tataatgaaa gaatgcgtat attctagaaa aaaacatttt tatatactat 3233221 ctactcttta tgataccaaa atacgcacaa aaattctaaa gactgtacga atttgtatag 3233281 gcagtctttt atgcttagca ggagggtcag ctagcatgct gcacagctat tttactgtga 3233341 aagaagcggg agaacacgag attgttatag aaaaatcgcg ttttatctgt catttaagcc 3233401 gtgtttctac cgaacaagag gcacaggaat ttatacagaa aataaagaaa cagcactgga 3233461 atgcgactca taattgctcg gcttatgtta ttggcgagaa tgatcatatc caaaaagcca 3233521 atgatgacgg ggaaccaagc ggtacagcgg gagtgccgat gctcgaggtt ttaaaaaaac 3233581 gcaggctgaa ggatacttgc gccgtcgtta cacgctactt cggaggcatt aagcttggtg 3233641 ctggcggatt aattcgcgct tatgggaaat cagtgtctga aggattaaat catataggtg 3233701 ttgtagaacg gaagcttatg cgaatcatgc atacttctgc agattacaca tggcttggca 3233761 agattgaaaa tgaattaagg gagtcacaat ttctgttaaa ggaaatccat tattcagaaa 3233821 atgttgaatt cgaaacatac gtggaagaaa aagaaaccaa cgctttttct gaatggatga 3233881 cagaactgac aaatggaaag agtgatatta aagagggaga gttgacgtat cttgaaaaag 3233941 ccgtcaatca cataaaggag actgaataat ggctgaacgc gttagagtgc gtgtgcgaaa 3234001 aaagaaaaag agcaaacgta ggaaaatttt aaaaagaata atgttattgt tcgcccttgc 3234061 actattggta gttgtagggc ttggcgggta taaactttat aaaaccatta acgctgcgga 3234121 tgaatcgtac gatgccctat cccgcgggaa taaatcaaat cttcgcaacg aagttgtaga 3234181 catgaagaaa aaaccatttt ctattttatt tatgggaata gaggattacg cgactaaagg 3234241 acaaaaaggg agatcagact ctcttattgt tgttaccctg gatcccaaaa ataaaaccat 3234301 gaaaatgctg agcattccgc gtgacacacg tgtgcaatta gctggtgaca caacgggaag 3234361 caagacgaag atcaatgccg cttacagcaa aggcggtaaa gatgaaacag ttgaaactgt 3234421 tgaaaacttc ttgcaaatcc cgatcgataa atatgtcaca gttgattttg acggatttaa 3234481 agatgtgatt aatgaagtcg gcggtattga tgttgacgtg cctttcgatt tcgatgaaaa 3234541 aagtgatgta gacgaaagca aacggattta cttcaaaaaa ggcgagatgc atttgaacgg 3234601 cgaagaagcc ttagcatatg cccggatgag aaaacaggat aaacgcggag actttggccg 3234661 taatgacaga caaaaacaaa tcttaaacgc gctgattgac cgcatgtcaa gtgcaagcaa 3234721 cattgctaaa attgataaaa tcgcagaaaa agccagcgaa aacgttgaaa ccaatattcg 3234781 cattactgaa ggtttagcgc ttcagcagat ttacagcggc tttaccagca aaaaaatcga 3234841 cacattgagc attacaggtt ctgatttgta tttagggcct aacaacacat attactttga 3234901 acctgatgct acaaatctcg agaaagtcag aaaaacgctt caagagcatt tagattatac 3234961 tcctgataca agcactggca cttccggtac cgaagacggg actgacagct caagcagttc 3235021 tggcagcact ggcagcactg gcacaacaac tgacgggacg acgaacggaa gcagctattc 3235081 gaatgacagc agcacaagct caaacaacag tacaacgaat tcaacaactg attcatccta 3235141 ttaaaaaatg cccggtcctt ttagaggatc gggcattttt gcgcagaaaa aaactccggc 3235201 acataagccg gagtttttaa ttccttttca ccagccgttt ataaaacttt gtaaacggct 3235261 taaatttttc attcacgagt cctgtcactt ctgctatgat ttgcataaaa ataatcaaaa 3235321 tgaagataat aaacaaagaa agccaaattg tggcactttt aagtacaatc gcactgatac 3235381 tgaaaataaa tccaattaaa taaataacta agaccgacat ccgatgtgaa aggccaaagg 3235441 ccatcagtct atggtgaata tgcgacttat caggcgctga aatcggctgt ttgtttaata 3235501 ttcttctgat gatagcaaat gttgtatcaa aaatcggtac gcctaatata ataatcggga 3235561 taacgatact gaacaatgtg acacttttat acaggcctaa taatgaaaga atcgagatac 3235621 tataccctaa aaacagtgat cccgtatctc ccataaagat ttttgccgga tggaagttgt 3235681 aaaacaaaaa ccccagcgtg ctggcaataa cgactaatga gagtgacaga atgagcactt 3235741 ttccgccgga tagcgccatg acagcaatcg ttgacaggcc gataacagaa agaccggcag 3235801 caaggccatc caatccatca atcaggttaa ttgcgttcgt gatgccgaca atccataata 3235861 ccgtcagcgg ataagccatc catcctaact caaatcgttc tgttaaaaaa ggtactgaga 3235921 aaaagtccat ttttaagcca gtgcttacaa tcataatggc tacacctaat tgaatcaaaa 3235981 acttaacttt tgcacttaat tgatatttat cgtcaagaat acctaacaca ataatgatga 3236041 atgctccgac tgtaattgcc gtcatccttg tttctgtgta aataccggat gcaagcacgc 3236101 ctgcaaccac cccgataaat atggccagcc cgcccatgcg gggcatgatt ttgtcatgta 3236161 cttttcgatt gctgggctgg tcaactgcac ctattttaat cgcaatcctt tttacgattg 3236221 gggttatgat taaaactgtc agcagcgaga caataaacgc aacaacaatg cgaatcatgc 3236281 gttcgtcaag cataaagaag tctcctttgg aattaaatga agtctttatt tatatagaga 3236341 accgttcctt ccattatacc ttctccttag ttattataac aagcttcatc aaaaagaaac 3236401 acgtataatc aaaaaacgcg catcccaatt tataggacta cgcatgtttt tgaatccctg 3236461 tatatttcat aatttgtcta aataagcaat tccaatcttg tgtccgggcg atgtttcggc 3236521 gcatttcttt ataggtctcg tctccgtttt gaccgagaac tttttcacaa gcggctataa 3236581 aatcaatcgg atgatcgccc tctacatatt cgtatacata cggcttttgc atttttgagg 3236641 ttgacggaag attagtgcct acaacaggtt ttcctgccgc taaaaattca aatagtttca 3236701 gcggaaacac agcttgatta tacggtgatt gtttatatgg cataatgcca atgtcgataa 3236761 gctccatata atgaggcact tcttttggat ctgccggacc ggtccatatg acattgggaa 3236821 gcctcagcag ctcttgaaac gaaacatcac cattggtggc atccgggcca acccataaaa 3236881 atgtccaatc aggcttttgc agtgccgctt ctttaatcat tttaaaatcg agcttcggtt 3236941 taatcccgcc aataaaacct aacactattc cttctctccc ctgcagtata ctgcgatcgg 3237001 gagcttgttt atttgcagaa aacagctcat actccacacc gttttccaca gtatgaacct 3237061 tttctcgtcc tgcagtcagt tttttgtcta cttccttgtg aagataatct gatgaacagg 3237121 ttattgaatc tgctcgttgt ataattctca gctctgccga tttaatgact tttcgccgga 3237181 attcagacag cagatttgat cggccgctga tcggcgcagc ccataggtca ctgcagtcat 3237241 aaatgacctg atcccaagaa tacagcgaag acagcagcgg gaatccggga aacgtgtacc 3237301 ataaacagca gcgttcaccg tttgcagaag caggtgtaag ctcatcgagt aatggggaga 3237361 gcttatgtct gtaaaagaca tctgtatatc gtccgaaacg aaacattttt ttctgcagca 3237421 ggtctttgac agcgaattgc ctgatgccag aatggacttc ctgaaactct ttcccttggg 3237481 cacgcggagc cggacatacc caaataactt ccttcgtttc ctcctgagca gctaaaaatt 3237541 ctgccagccg gtgccttctg tatctcaatt ggtcttttcc ccattcagca gtggcaacga 3237601 tgacatgaat gattgcttct tttgtttcca ccttcatcac cttttctctc tgtttgcagc 3237661 tataatcttt ttttcaccgc gttttttgca tattgaacaa aacaccatgt tgctttcata 3237721 aaatgaagcc gttcgatctc cctgtagaca aaccacgttt ttttcgcagc cttccatttg 3237781 ttgctggaaa ttgaattatt gacaagccga tattcagcca ggcattcatt cattccatag 3237841 gcagtaaatc ctttttttaa aagagacagc catgtggcta agtcctgtct cgttctgata 3237901 ttcggcattt ggatctgtcc cgtttgctcc ctgtcaatca tcaccgtcaa gcagccgata 3237961 attgtatttt tcagggcgtc atcgtacgtc aggctttccg gcgcatgaat aaatttatcg 3238021 agcggggtcc cgtcctgcgc cattaagctg tagcccgtga aagagaacgc acaggagcgc 3238081 tccatcataa actcaagctg cttttccagt ttgtcttttt tccatttgtc atcactgtcc 3238141 aaaaatgcta cgtagcgccc ttgagcgcgt tccaacgctt tgttgcgagc aaccgcagct 3238201 ccggagttct cttccagata caccacatga attctttcgt ctattttttc atactgctgt 3238261 aaaatgtcgc gggtcccatc cgttgagcaa tcatccacga taatcatttc ccaatgagga 3238321 tggctctgat ctaataccga atgaaccgtg tcttcaatat agtcacgcgc attataggaa 3238381 ggtgtaatga cagatacgag aggtttccaa ttggtcatga tcacatctcc atcgtatgat 3238441 tttaaaagga ttctctgaaa aattcaggaa tgacaacgaa cataaaggca atcgtaaggc 3238501 caatcataac gccgagaact gctttctttt tcggagacat accgccgcct gctgtctcac 3238561 ttacggtttc ggaatcagta acacttgccg ctttcaggtt aagctgtgtg tttttgagtt 3238621 catataaaaa tctctcttta tccactttgg aatcctcgct caccgactcg ccttcaagcg 3238681 cgtctatgct gctgcggatg acggcttctc tttctgcata cagcttttga tcgtttttga 3238741 ggaaggtgga ggatatggcg tttaagacag attccgttct atccttatcc tcgtcactat 3238801 agcttaaagt cagtaacgat ttggattccg tattgattgt aagcttctct ttgatctctg 3238861 ctacatcttc atccttttca tcaggaagcg cctccttcaa aaaggagtcg ctctttaata 3238921 gaagcggaat ctcttctgtg ctgttataaa ccggatgatc atagctcccc acagccaaag 3238981 tatcttcagc tgtatagctc ttttgatcag cgatctgtga cggcaggata taccccgccg 3239041 cacctaatat aattggcacc gctatgatcc aaatgatatt tttttttatg cgacgggcta 3239101 ttcttatcaa tatatcgttc atataagtct ccctgctttt tgtagtctgt ttatctgtac 3239161 atcggctcag gcatttgtct ggatcgcctt aacacattca cggcggcgat gacgagcgcc 3239221 ataaacaccc aatggaaaaa taaatttgaa acagagcttg ggctgatact tgataccagg 3239281 aaactgacca tagcggtaat aagtccttct gtgatcagtt ttgactgatt ttctaatttt 3239341 ctttcataaa acttgtaaag cacccatatg aggtaggcat aaacggacaa atatcccagc 3239401 atgatgaaca aaccaaaatt agcaagaatt tcaacaagcc agttatgcac ctctgccaca 3239461 ttgtcagtat catatacagc ataatgctca agataatagg atacatttcc tgccccgact 3239521 ccgaatccgt atgaatcaag gaaaaaatgc caagcgtttt tcagcagatt tgcccgagcc 3239581 acatttgatg gaagcctgtc atgaaatgaa tgcagcgtct gcggggccag aaacagctcc 3239641 caaaactttg aatagatttt gctggcgaaa agaactgcga aaagagcaat tcccgccgcc 3239701 gacagccata tagccattct ctttaaaaca ggcggcaata caatgaagat gtagacagca 3239761 atacctgcaa aaatgcccag aaggctggct cttgaaccag tggcaaaaat taaatacaac 3239821 gcacagagcg agagcacaag gccaattgcc ttgatgtatc cattcttaat gtttttcatc 3239881 atcgtgatgt aaaaaaagaa gctgatggat aaaaaggtcg caaagtcatt ttgattaaaa 3239941 aagaccgatg tcggataatg ctgcttgtac tccggtccgc tgtacaatgt ggaactcgca 3240001 agatgatggt gggtgatatg attgtaaaaa ccaatgatca tcagaaatac cgtcatcacc 3240061 agccaaatgg cataaacaat catcagccgc tccatttttt gcacgtacat gacaataaga 3240121 taaatgaaga agatccccat tgccaataag gctaaatact tgaggccaac tgttaccgac 3240181 ttggcccaca gcagagaaac aaggccatat ataaaccaaa aggcgaaaaa gagtaaaatc 3240241 ccttttactt gcagcccatg ccatctttca atatgggttc gattccgaac catgccgaaa 3240301 atatgaaggc aacccgctgc aatgagcaga agccggtaaa ggaacaaact gaaaaatcca 3240361 agatgaatgg caaaaaatgc attatttaaa aaagtgcagg cgatcaaaat atagattaca 3240421 gccataaaga gccgttcttt tgttgtaaat gcggttgcaa gcgtcagtaa aaacaggcca 3240481 attgccaaca ccgcaagcac agcagccatc tgcatgaaac ctatatcttt atggatggct 3240541 cccagcaata ggacgactcc aaatatagca gcggccagta acgctagcgt atggaccgct 3240601 gatcgtttga tactcacatg tttaacccct ttcctgatgt ttcaggagcc ggcggccgag 3240661 cctagcagcc ggcagcttca accaagtaac actttttctt tttataaatt gacgcttccc 3240721 aagtctttag ccaattcttc aagcggcaag cccggaaaat acttgtcaga gggttccgtt 3240781 ccccgaacag cgggacggcc gatagagtga taaatgtatc cggctgcctg catctcttca 3240841 agtgaaaata aatttctgcc gtcaatgatg actggctgtt ttaagagggt tttcactttt 3240901 acaagctcca tttctttcac ttccggccaa tccgttaaaa tcaggcatgc atcagtgtct 3240961 tccatcgcag catacacatc tgtgtaatac tcgacctgtt cgccaaggat cgctgaagct 3241021 tcaggaatag caatcggatc gtatgctttt acatgggcgc ccagctgctg cagcattggg 3241081 ataatatcaa gcgctggagc ggatctcaca tcgttcgtat tcggtttgaa ggctaatccc 3241141 aggactgaaa tggttctccc tttgacgctt cccataacag tcaaaagttt atctacaata 3241201 tgaacacgct gcttttcgtt cgtttcaatg acagcttcga tgagcttgaa tggatagcct 3241261 gccgattttg cgatttgaag cagcgcggtt gtatcctttg gaaaacatga accgccgaat 3241321 ccaataccag ctttaaggaa ctttctgccg atacggctgt caagaccaac accatcagca 3241381 acttttgaaa cgtctgcgcc gactcgctca caaatgtttg cgatatcgtt gataaaggaa 3241441 atctttgtcg ccagaaatgc attcgcggcg tatttaatca tttctgcact ttctaggttt 3241501 gttttaatga caggagcatg gaatggctga tgaagttcct caatgatggc agcggcttta 3241561 tgacttgttg aaccaatcac ggcacgctcc atattcatcg tgtcatgaat cgctgaccct 3241621 tcccgaagga attcagggtt agatacaaca tcaaatgagt atctcccctt tgaggctttt 3241681 tgaacgatag attgcaccag tttccctgtt ccaaccggga ctgtgctttt atttacgatc 3241741 actttgtagc cgttaagatg ctcaccgatt gttttcgccg ccgctttgac gtacgttaaa 3241801 tcagcttcac ctgttttgga cataggcgtt ccgactgcaa tataaataat atctgaggcc 3241861 cgaatggcag acgggatatc gttcgtaaag gtcaggcgct gatccagcac atttttttca 3241921 actaagtctg caagccctgg ttcatagatt gggattaccc catttttcag gcttctgatt 3241981 tttgattcat cgatatcaca gcaaacaact ttattgccga tctccgcaaa gcaagtgcct 3242041 gatacgagtc ctacataacc tgttccaatg acagctattt ttttcacagc gctcaaccct 3242101 ctcctgtaaa atgatcttcc aatttataat ggtcgcagtg tcttacgatt aaacggacgt 3242161 tttcgtgacc gtctgatact gatgatgcaa ggccttggcg ttttttcctg cgtcaaattg 3242221 agcctgcacg gtttcataca agtcatctgc tacttccggc ttccatattt gctcatgttc 3242281 gtaccgagtg atcgcttccg ccaaggcttg agcggatttc ggtttaatca gcagatgttg 3242341 gtgctttccg aataaagacg acactccgcc aacatccgta caaataacag gaacccttag 3242401 cgccagcgcc tcaatcacaa cagtcggcat cccctcactg taagaaggaa gtacgaatag 3242461 atctgccgca agtaaatagt ctcttacctg atgattcggg acttggcctg tgacgatatg 3242521 ccccttctgc gtcagcgtcg attttgcggg accatccccg acaaagactg ccttaggaga 3242581 gtcctgcagc gattcgatcg cttcagacag ttcaaaaatg cctttctctc tgaccagccg 3242641 gccgacatag acagccagac gctgatcgag cgggagtccg agtctttttc tgatttcctc 3242701 tttcgtctcc tcattcccct gaaaacggct gagctgtatg ccgattggca aaaccgagct 3242761 gtcaaagccc gaaagctttt tggcttcttc ctgaagcttg tggctgactg ctaaaacaac 3242821 tgacgcagaa cctacggcac gcttgaaggc tttaaacgca cctttgctgt aatgcggata 3242881 gacattcaca tcactgccat gcaaggtcag gacataagga atttgcgctg actctgacac 3242941 gactgccgca gccccgcccg atggcatggc aaaatgcgca tggatcagat ccggatatag 3243001 gtcgcgctgt ttcattgttt ttaaaacggc tgatgcgatt ctccgatgag gctgcgccca 3243061 cttcagctgg ccgggaactg cccgatagaa aggccggtaa accggtatcc cctttctaat 3243121 ctcatactcc ggtctgacat ccttttttcg atatgtcttt ttcagcatgc ggacaggtgc 3243181 tgaatgaaaa ggccgtgggc atatcacagt gatatcaagc ccgagttttt gcagctcttg 3243241 cacctgtgtc tcatgaaaca caccctctcc gggtttcata ctgctcggat atacgcttgt 3243301 gatccacaaa atcttcatga caaacgtcct tttcttagta gtttgctttt cgtttgaggg 3243361 tacgctttta ccaaaagaaa gagatagcac agcgccccag ccgcaactga aatggccagc 3243421 cgcatttctg cctgcatact gaagtgttcg gtactgaggc ttacaccaaa cgcgatgatg 3243481 cccatcgccg cagtaatcag aaatggcttc ataatcgact ggaaataagc tgaaaggtta 3243541 agcttgatga catatgccaa aagccagcgc ccaatcagga aattaacaac gctgataatg 3243601 gcatacaccc atgcgactgt cagcaggctt cccgtctgta cagctgcaaa cagtgataat 3243661 ccgtacagca gcagcacgcc ggaatcccaa taaaacgcta agtcagctct tcctttagcc 3243721 agcaacacag atccatttgg attcatgagc actcttagta ttccgacaat cgcaagaaca 3243781 tttaggatcg gaacagcagc aagccatttt tctccgaaaa ccgctgtgat aaaggcgtct 3243841 gacacagaca cgagcccgat taacagcgga aacgaaacaa gcgccagcat ttttgtcata 3243901 ttcagaaagc cttctctgat cacgctgttt tcatatttgt tttttgcgaa aatagggaat 3243961 gccacccgtg tgacaatcgg attgatcttc aaaaccggaa tggtgacaat ctgataagcg 3244021 aggttataaa tccccaatgc ttcagcacca ataaaccggc cgatcaaaat catgtcgata 3244081 tttgctccca gcctgttcac aagacgggat gaaagctgaa aggctccaaa agaaaagaaa 3244141 tccttcatgc ctctcaaatc aaaaacaaaa gcaggatgcc acttttttcg gtatacagcc 3244201 caatataaaa tccctttact ggactgcagc aggacttgag aaatcacgta cgccaaaatc 3244261 gcatccatca taaaaaccgc tatcgctaaa tatccgaatg acaatacatt tgaaaaaatc 3244321 tctattttgc ttaacgtatt aaaatgcagc tgcttttgca gcatatactg atattgctgt 3244381 ccaattggcg cgatcaaaaa cataatcgcc agaatccgaa ccagaaacac cagctcttct 3244441 ctttgataaa atcccgcaat gacaggactg ctcacatata aaagaacaaa cagcaaaacg 3244501 cccgtcataa tgttaagcca atacaatgtt gacagctggc gctccgtcgc gtcgtctctc 3244561 tgaattaatg ctgcgccaaa acccatatcg agcacaatct gggcgaaaac tgtaaccgtt 3244621 gtgatcatgc cgacaagccc aaattctgtt aaggtcatca tatttccaag cagggcaaac 3244681 tgaacaattt gtatgattgt aatacacatg gttgaaatac ttgtccactt tgcaccgctc 3244741 atgatttgtt ttgtaatact tggcatcata ttccctactt ctttttaagc tcagattgat 3244801 ggtgaataat ggaatcccgt tttatcttgc accatcaccc gtccaaacta ctttacaagt 3244861 ttttaacata atttttaatt ctaaagtgaa agtcagattg cgaatgtaat ataaatcaaa 3244921 tatcagcttt tccttcggcg tcatatcgta accgccgttc acctgagccc agacgctgtg 3244981 taaagcctgg aatctcattc tggaattttt ccgtaaatac gggccgttcc ggacgagggc 3245041 caatcatact catatcgcct ttcagcacat taaacagctg aggaagctcg tcaattctcg 3245101 ttcttctgat aaaagctccg atccttgtca cccgcggatc ttgcttctgt gcccaaaccg 3245161 ccccagactt ctcggcatct attttcatgg aacgaagctt ataaagctta aatggcttcc 3245221 cgcctttccc tacgcgttcc tgcgtataaa tggcaggccc cggcgtctcc aaacaaatca 3245281 aaattgaaaa taccgcaatc attggcagcg caatcgccaa tccaatgagc gcaaaccaaa 3245341 tatccattac gcgctttatt gccaaataac gagccgtctt ttcagataat gtaaaagaat 3245401 gtatttgttg aactgagaat tcacgactca cattcatgct tttctctgca ctcactgaca 3245461 cacacctcac gatttgtttg ggatgttatg atgacctatg ccagtcagtt tagcagacgg 3245521 atgttaattg gatgtaaatg gtatgttaag aagtgtgaat tacgtgtttt ttctgataaa 3245581 tgttgttaat actcttttac tattttatat acaagtccta tttgttttaa tcatttcata 3245641 taaaaaagag acaaatctgt gattagattt gtctctttcg attatctgta ataagatact 3245701 gtgccgtcat gaatagcttg tgcagcttta tctttataaa ccgcttgctt caatttactt 3245761 gcatctgatg cattagtgat aaaggcagtt tcaactaaaa cactcggcat tttagaatat 3245821 ttaataacat agaaagcagc tgtttttact ccccggtctc tcgttccaag attagccgct 3245881 aactttggtt gaatttgttc agccagtctc ttgctatttg cagcttgata tgttgtatcg 3245941 tagtacgtct cacttccatt tggtgatgag ctatcattag catttgcatg tatactgaga 3246001 aataaatctg cttgtgcaga agctgcttta tttactctct cctgtaaaga ataaaaagta 3246061 tcattagatc ttgacagtac tggaagagca cctgaagcat ttagctttgt attgactctt 3246121 ttcgctatat caaggttgac ttctttctca aggagtccat tgccgattgc tcctgaatct 3246181 tgatcaccgt gacccggatc aataaagatt gtttcaccta caactggatt ctttagctga 3246241 ttagcaacct ttgtgcttac ggcaggagtg tttccgataa tcataaagtt tgacatgttt 3246301 ttacttccaa taattttacg ggctcctgta gataaatttt caccatttgt aagaataaga 3246361 gattgcttct tcttagctgc cagtgtagct cctgcaatag agtcagggta gctgaatcca 3246421 ttgcttacat atacggtgct tgttgataaa ttaagttttt gtacgatatt tgcagcaagc 3246481 tcatatctgt ttgaaccgct aattcttgta ggagaaggta acttgttgta taccgtattg 3246541 ctgatacttc cagtgcctcc tacaacaacg gtactcgaaa ttcccttatc ttttatcaca 3246601 gacgtagtcg cactatttat agatgtttta tttgtaaaaa gaattggata cccgtttttc 3246661 gctgcataag ggatgacggc cggagcgtct gcatataaga agccgttcaa aataacagct 3246721 tttgaagtcg cacccatcgc ttttgccacc cgtgcagccg tatcataacg gttgcttcct 3246781 gcaattcgtt taatacttat ccccaagctt ttaatctggt tagcagtgtt agaagaaaca 3246841 gcaggtgttc cgcctacaat aattacattt ttagtctgca tctctttcaa tcttgttttc 3246901 gtttcatatg aaagcttatc agaattagtg taaagcaatg gcgcattctt ctggtaagca 3246961 agaggtgctg ctgaaatagc atctgcatag gaactcccac caacaattac agctgtactt 3247021 gctgttgaat acatttgctt tgatatttgt acagcagtgc cgtatctatt gcttccccca 3247081 actcttttca ctgagttatc ggccaaagct gttggcacaa aaagtatgag ccccagaaaa 3247141 cacattgtta ggacttttat ataagaacgc aattgatttc ctccttaaat ggcgttatat 3247201 cctaaaataa tcaataactt gtcagagttg tacctggata gtaaaatttc aaaattgaac 3247261 tatatgaatc tccagcttct gctcttgctt ttgctccata ttgactcatt ccgatcccgt 3247321 gaccatatcc tttaccgctg attgtgtact ttgaagtatc tttttttaca gtcacataag 3247381 tacttttaaa tacagtcgct ccaatcattg ttcttaactc acttgttggt acactaatgg 3247441 ttgtaatttt gctcaagtta taggagccag tactgctttt aacaaaatac ttcactttca 3247501 tcgatgctgt ttttgcacgc tgcccttgtg tcgttccact aaagcttaaa tcgtcaatac 3247561 ttgcaatttt gacagaatca gcgcttgttt ctttattttt caagatccag ttcttaactc 3247621 cggaaagtct tgcagaatca gtttcagtcg ctgaagacca ccaagaagaa ggcttcgtta 3247681 agtccaaaga tttcgtatct agctgttgtt ttgacaaagt aagcgtccag cctatttgag 3247741 gatcctttgt atcttttttt gcaatcaagt aaggtacact tgacgaccac acttcattac 3247801 tagcttctgt gtaaccacca ttactggaag aataagctgc agttataaga gatccattat 3247861 atttcagaac tttccccttc gtttgctcta ccgctttatt ggtattcgaa ttccaactgt 3247921 agccaccata aacttgaaaa gcggttgtat caggtacagt agttcctgtt tttgttattg 3247981 agtaggttct tgcagcgaca gtctgtgctt taagagcctc aagtgaccag ctagcaggca 3248041 tttcattcgg aattactcct tttaagtaat cctcaaatgg aatattctca tttaccggtc 3248101 ggatatattt agtagactca atagagaaat taaccgtgcc aagatactgc tttccatcaa 3248161 gactaattct gtttgaagta gaatagtttt ctggtttaat tcttagggag tttccgtaag 3248221 ttttgatgtt ttcaaggttt aattttccgc tgttgatttt tagattatag gtgccaccgt 3248281 cagctaaata aaattcatca gcaagtgaat tctcaacttc agcagaaatt gaactggtac 3248341 ttccaataaa gtcgtatgca tatgtggctt tatctttcgt tatactttta gccgcagccg 3248401 gaacgctatc ttgtttaaca aataaaattt ggctgttttt cttcgaggca agcgaagcgc 3248461 ctatcaatac gtctgcatat tttgtcccgt tcgtcattac gactttatca gccttcaact 3248521 ttagttgctt aattatattt gccgtaagtt catatctggt tgatccagga atcctttgca 3248581 cagttgaagt ttttttaatt tggttttcta cactatcact gacgctaaat gaactgccta 3248641 taatgatgac ttgttttggc aaatcataat ccggaagctt gtctttctct gtaagcaaaa 3248701 tagggtatcc gtgtgctgct gcatatggag caatggctaa agcgtcttga aatactcttc 3248761 cggttacaac gatcgcttta tcatagctgc ccatttgctt tgcaatattt tctgataaga 3248821 catatctatt ttttccgctt atccttttca cagcgccata tgatttcagc ttgttttcta 3248881 cgtcttttga aatgcttcgc gctcccccaa tgattaaaat attatcaggg ttaaacttag 3248941 caatttgtct ttcagtagtt tttgttaacg tgtcaggctg agtaaataaa actggtgcgt 3249001 tcagtttttt cgccaatgga ataacaggca atgcatcaat aaaaatatct cggttcacca 3249061 atatcactgt attaggattt ttccactggc tgttggatgc aagagtcgca gtttcgtatc 3249121 gtgaagcgcc tgcaaaacga tccgtaacag caacattatc tccagttact ttataaaatc 3249181 ctgttggcga tagactgatg ctagatttat ttccaatata atttaacaat ttaactgaga 3249241 tgtttgagtc tgctgcaaaa gaaactgatg gaatcaataa taagattgca gcaagtgaac 3249301 acactatcaa ttgtttgcaa gatttcaaaa tttcaggttc ctccctatat cttagttggc 3249361 acgttcaata tcttttaaca gaagctgacc ctcatcattt ttttcatatg taatcgtgac 3249421 cttatctcca ctgttaaact tatcaagatc acttgtcgat tcttcagtga tatcaagact 3249481 aaccggctca ttatctactg ttacttctat tgtatgagta tcagctaacc ctacataagt 3249541 accttctttt gtttcaatgt tactgtctgg cgatacatct tcaccttgac tcttttgact 3249601 attaaccccg caacccgaaa gaagcaatat aaagaacagt aaagcaataa attttttcat 3249661 ttttttcacc tcattatatt ttatcgtcaa cctattttat attttaaaga aaaattaaga 3249721 aacaatgaaa ctttttttta taaaaaacga ctattttagg atttcattct tgtattaaat 3249781 agagttgtat ttattggaaa tttaactcat aatgaaagta atttaacaga cgaggtgcaa 3249841 aggatgagaa acgaacgcag aaaaaagaaa aaaactttat tactgacaat tttaacgata 3249901 atcggacttc ttgtactcgg aactggcggc tatgcatact acttatggca taaagcagct 3249961 tcaaccgtgg caagtattca tgaaagcatt gataaatcta aaaagaggga taaagaggtc 3250021 agtatcaata aaaaagatcc tttttccgtc ttaatcatgg gtgtggatga acgcgacggc 3250081 gataagggcc gtgccgatac gctcatttat atgaccgtta acccaaaaac gaatacaacc 3250141 gacatggtca gcattccgcg tgacacgtat acaaaaatta tcggaaaagg cacaatggat 3250201 aaaatcaacc attcatacgc tttcggcggc acacagatga cggtagacac tgttgagaac 3250261 ttcctcgatg ttccggttga ttattttgtg aaagtgaaca tggaaagctt tagagacgtt 3250321 gttgatacac ttggcggcat tacagttaac agcacattcg cgttcagtta tgacggttat 3250381 tcgttcggca aaggagaaat cacgctgaac ggaaaagaag cgctcgctta tacccggatg 3250441 agaaaagaag atccgagagg cgacttcgga cgccaggacc gccagcgcca agtcatccaa 3250501 ggtattatta ataaaggcgc taatatttct tccatcacga aattcggaga tatgtttaaa 3250561 gttgttgaaa ataatgtgaa aacgaacttg accttcgata acatgtggga tatccagtcc 3250621 gattacaaag gtgcgcggaa acatattaaa cagcacgaac taaaaggtac aggcacgaaa 3250681 atcaatggaa tttactacta ccaagctgat gaaagcgccc tttccgatat tacaaaagag 3250741 ctgaaggaaa gcctcgaaaa gtaaaacaaa aagaagcttc gcacaatgtg caaagcttct 3250801 tttttatttg cctgtaaatg aatccggttg ttcttttcga tacccgtaat gaaacagcaa 3250861 ttcttccaca atccggcggg aagcctctcc atctccatac ggattagaag cctgggacat 3250921 tttcttgtac tcatcaggat cagttaacag ctgttttgca agctgataaa tgttttcctc 3250981 atccgtacct gcaagtttca gcgttcccgc ttccactcct tcaggccgtt ccgtcgtatc 3251041 acgcagaaca agaaccggtt tcccgagaga tggggcttcc tcctgcacgc cgcccgaatc 3251101 ggtcaatata aaatgcgatt tcgctgcaaa gttatggaaa tcgatcacct ctaaaggttc 3251161 aatcagatgc actctgtcag aatcaccaaa atgcttatga gccgcttccc ggacaacagg 3251221 attcaggtgc acagggtaaa cgacttgtac atcttcaaat tcccctacaa ttctgcggat 3251281 ggccttaaac atgttttcca ttggctcacc caaattttcc cggcggtgag cggtcaagag 3251341 aatcatttta tcctcaccca cctgatcgag aacaggatgt gagtaaccat ccctaaccgt 3251401 tgtgttgagt gcgtcaatcg ctgtattgcc cgttacaaaa atagagtcgg cctttttgtt 3251461 ttcttttaat aaattgtctt tcgcctggcc tgtcggagca aaatgcaaat cagcaatcgc 3251521 ccctgtcatc tgtcgattga gctcttccgg aaacggggaa tacttattcc ctgtacggag 3251581 ccccgcctcc acatgaccga cagcaatttg atggtaaaaa gcggctaggc ttccggcaaa 3251641 cgtcgtcgtc gtatcaccat ggacaagcac aatatcgggt ttgatatctt taaacaactc 3251701 atccaatctt acaagtgcgt tagacgtaat ctctgccagt gtctgccgct ccttcataat 3251761 gttcaaatcg aagtcaggct tgatgtgaaa cgcatctaac acctgatcga gcatctgtct 3251821 gtgctgtgca gttaccgtta cataggaatc tatttcagga tattttttca attcaagcac 3251881 aagcggtgcc atcttgatcg cttcaggcct ggtcccgaaa acggtcatca cttttagttt 3251941 tttcatattt gtcacctggt tttctgctat agtaaataaa ttcatactac atattctaca 3252001 tgaaaatgca tcattttaaa tcatttcatt cttgattcaa ataaaatgat ataagtttta 3252061 atattaagga taaagcttgt ttaaaaatgg tttatccgat atcataaaaa tgtgtaaaaa 3252121 catattgaaa agggtaaata gagaatagtt taaccataaa ttttttcgat cataaggaag 3252181 gtgcctttta aatgaaaaaa gtacgtaaag ccataattcc agcagcaggc ttaggaacac 3252241 gttttcttcc ggctacgaaa gcaatgccga aagaaatgct tcctatcgtt gataaaccta 3252301 ccattcaata cataattgaa gaagctgttg aagccggtat tgaagatatt attatcgtaa 3252361 caggaaaaag caagcgtgcg attgaggatc attttgatta ctctcctgag cttgaaagaa 3252421 acctagaaga aaaaggaaaa actgagctgc ttgaaaaagt gaaaaaggct tctaacctgg 3252481 ctgacattca ctatatccgc caaaaagaac ctaaaggtct cggacatgct gtctggtgcg 3252541 cacgcaactt tatcggcgat gagccgtttg cggtactgct tggtgacgat attgttcagg 3252601 ctgaaactcc agggttgcgc caattaatgg atgaatatga aaaaacactt tcttctatta 3252661 tcggtgttca gcaggtgccc gaagaagaaa cacaccgcta cggcattatt gacccgctga 3252721 caagtgaagg ccgccgttat caggtgaaaa acttcgttga aaaaccgcct aaaggcacag 3252781 caccttctaa tcttgccatc ttaggccgtt acgtattcac gcctgagatc ttcatgtatt 3252841 tagaagagca gcaggttggc gccggcggag aaattcagct cacagacgcc attcaaaagc 3252901 tgaatgaaat tcaaagagtg tttgcttacg attttgaagg caagcgttat gatgttggtg 3252961 aaaagctcgg ctttatcaca acaactcttg aatttgcgat gcaggataaa gagcttcgcg 3253021 atcagctcgt tccatttatg gaaggtttac taaacaaaga agaaatctaa acaaaaaggc 3253081 tattggacat tcatccaata gccttttttt atttcaacat caaagtcaat gtatgctctt 3253141 cattatcaac tgcgaagacc tgatcaacgg cctgccgcaa aaattaataa tcccagacaa 3253201 acacactgat tgtagagtta aacaaactaa atgaaaacat aaatacaaac atgcagatta 3253261 aatagtaaat atcttgtatt caatgcaagc taagtaaaca ccacttgcta aaagaacaat 3253321 gactaaacaa ccagcattac aaaataatta aataaatttg aagcaattac aacagaaggc 3253381 agtgaactgt cggaaagttc attttggcta ccatattaat ccctttaact acgctgttgg 3253441 atttatcaag aattgtcggg ctaatagaaa accacggaat caaaccagcc agcattcaaa 3253501 cgataaaagg cacttctccg atacctgtta tgaccagctt actgttgcgc atcccaaata 3253561 caaaccagta cgccatcatt agaataaggg gatttaaaac ctgccataat acaccaaaat 3253621 aattgatttt ttggatcttt cggttaaaga aatttaaaag taccagtgaa tattgtaaca 3253681 aatgttgagt ttttttcact tttaaaaagt aaagagaagt ctcgcagaac ttctcccaac 3253741 atttgaagtg tcaatataaa acaaaccaac ctcatttagc aactttatta ttatctaatt 3253801 ccaaaatagc attataaata cgattcctat tatttttatc agtatatgca aaaaagttat 3253861 ctactctttt tctatactta tcttccatac gactattgtt tttcatataa tagataactt 3253921 tatccactaa gctattatga ttttctaata catcaccaaa ccccattttt ttataatcat 3253981 aataatcaag tttaaaatgg tatgactttt cgtattgata ataaataaca ggttttttct 3254041 catatgcaaa atcaaacgca acagatgaaa aatcagtaat cattatatta gaagaattaa 3254101 atagcatttg atagctgctg ttatagtcgg caaactccac ataatcatgc ttttcaaagt 3254161 ctacaatctg ttgctgaata tctgggtgag gaaaaaaagt tattttataa ttatttttct 3254221 tagcaaattc gattagccgt tcatcattaa tcaaagcatt atacctagaa aaatattcac 3254281 tatctttaaa tttcgggttg tacggtctta ctccttttgc ctgatctttc ggtaatacaa 3254341 tatcttttct ccaagtcggc attattagaa gttgcttttc tccctcactc ttcttaagat 3254401 tatcgtatct cggaaatcca cccaacaaaa tattctcttt tttatagttg taattccctt 3254461 tcacaataga ccgatattca ggtttggcag aagtgactaa taatttgata ttcttgttgt 3254521 atttgtttaa ccattcagaa tgatctgcca ttgttattcc gtgctgtaaa aagataaact 3254581 caaagttaaa taaatctcta aaataaatct ccatattaaa aaatggattt acaacccata 3254641 tatctgcatg tgtcgatatt actttggaag aggataaggt taaaatttta tgtctaaaag 3254701 atctgtatgg tatgaccttt ccatattttt tgattctgtc gtaatccttg ctatcttttt 3254761 ttattataaa gtattttttt accccatcat tcttgttgat tgcatattta aagaggtgct 3254821 cggcattatc atcagctttg tcttgtctgt ctatgaataa ccatactggt tttctattaa 3254881 aaatagtgaa aacatggtgt accattcttg ccatcagtgc cttcttaatc gctgattttc 3254941 gtttttttga tttttcccct gatttatgta gggattttaa gaaacgaaac tcttttataa 3255001 atctattttt aaaattgttt tttttgaaca ttaatttttt ataattataa taaaaaatat 3255061 aatctttttt agccacataa gtattatata aatcgtttga caaacctgaa tacttgaaaa 3255121 aacgaagttt tgtcaacttc ctttttttac ccttagttat aaaaaactca atatgatgat 3255181 tatctgctag atgacctttg ggaatatcta ttgaaaaacc gggatatttt tttattactt 3255241 ctcctaaact tatataatca ttatgctgtc tttttatatt ctttgctttt atttttgttt 3255301 cgccaatttt agcataaaac ttaaaacctt tagaattaaa cagcgagctc caaaagcctt 3255361 ctatgtgaat ggaatcctca ttttcttcta aaatttcaat agttaaagtt tgatccgata 3255421 atttcgaaac aattttacct tctctgtata aataataatc ctgttcagtt tctctttcat 3255481 atacatacct actataattt tcaccgtgct ttatttttaa agcatgatat aaatagaaat 3255541 ggctgacact ttttgtttca atgatgacat cgtcgtcaat atacgacaat acttctcgaa 3255601 tcaatgttaa aaattcactg tattcatttt cgtctaaagg tgtttcactg atatccttaa 3255661 tcaataattt ccacttcaaa tcatgcataa ccatatattg aagaaataaa ggtattttct 3255721 gttcatgatt ttttataata tcgattaaat tctttgagaa agtgataagt gaatggttaa 3255781 accaattctt atttgcttta gcagtctgca tggcagatga tccatcttct ctaactctat 3255841 aatggtattt tgcctcttta accagaccat actttttctt ttgcgatatg attaaattaa 3255901 ctagtttggc atcttcacct attttacaat tttcatcaaa cctgatattt ttcaaggcat 3255961 ctttttttat aaatgtagaa caacaatgag ttaatatatg atgcggttct ttttctacat 3256021 ccaaaattct tgtagaagaa aacttattat ttagattatg ttctccagtt cttccttctg 3256081 caaaaaaaat agggattgct acaatatcaa tttcattctt atgttcgtca aagaagttta 3256141 aaacattttc gaatgttcct tctgaaacta aatcatccgg atccaaaaat tgaatatatc 3256201 taccttcagc atactttaaa ccataatttc gagcactgct cactccgcca ttctgtttct 3256261 ttgcatagac aatgttattg ggatatttct gagcatattc tttacaaatg atttcacttt 3256321 tatcggggct atcatcattc accagtatta actgaatatt ctcaaaacca atagtttggt 3256381 taatgatact ttctatagct tcagtgagat acaactcaac attataaatc ggcattataa 3256441 cactgaaatc atagttaaaa cttttttcgt tcataaaaga ttactcctaa cataatgttt 3256501 atatgaataa gaattcgggt aaataaaatt aagaaacaag agagtactaa tttttgcaaa 3256561 acaattttaa tttagtaaaa tgtatgaaaa gcattcctta ccttttttta aaaacccttg 3256621 taagcaaact tttaaaaatg ttcacatggt taagttctaa agaatcattt ggtgttttta 3256681 gtacaaagtc aaatgcaaag gcccaaatcg gtatttcgac aacaaaacca gcatatctaa 3256741 aatctcttaa tttatatccc catacttcaa ttgttttttt cagttctttt cgtttgcatt 3256801 tttttaatct tttaaaatat tttatatata ttctgtcatt ttctttcatc tcataatact 3256861 ggttaataaa gtgccctgtt aattcaagtc taagcccttt tatttttgcc gaagtaacag 3256921 tacatgaact atgcagtact ctttcttttt ttatattttc aagagcttct gtattttctt 3256981 ttaataagtg aaacataaat tctttatagt acatcggcat atcttgttct tttataaatt 3257041 gcgggtcaat aaattttaaa actttaataa aatcatcaac aaaaactctt tgttcttgtt 3257101 gatctaaaac agacttataa acatctctat agttcggata taaaaacagt tttatatgat 3257161 atacaattaa aaattgcaaa taaggcaaaa ctatatcata tttgttgaat gaatccatca 3257221 acaaagtcat gtaacattca ttcaacaaat atgtgtacct ttttttgtta aaccatgaac 3257281 gatcaactaa agaatcctgt tctttccgtt ttctataaaa atactttcct tctgcaactg 3257341 ctccgtatct tttttctttc agtaataact ggttaaaaaa gatagcgtct tcccaaaact 3257401 ttatagattc atcaaaaagg acggtactag ttagtgtatg tcttctgtaa aaagtgccgc 3257461 caatataaaa atgaatagct ttataatcgt tgagaatatt tataactctt gttccttttt 3257521 caaatctatt atttaattta tgtccccctt ctttttcacc tgtgtaataa acaggtaata 3257581 ccgcaatatt tacatgttcg gaatcacaaa aaaaatcata aacactttgc agcgcatttt 3257641 gagagaatgc atcgtcagaa tcaagaaaac caataaattt agatctttcg cttacatttg 3257701 ataatccaca atttcttgca gcagaaggtc cagagttttc aattttcatg attttaatat 3257761 tattaggata tagattttta aaggattcac aaatttgagg actgctgtca acactaccat 3257821 catctattaa tatcagttct atattttcct taaatccaat tgactggtta aggacactct 3257881 ctattgaata tcttaaataa ttttcagaat tatatattgg tataattata gaaaacatgt 3257941 ttgtacctct ttatttagaa gttaaaggat cgtttcaatt actcttttag aagccttgcc 3258001 tcttctaaat tacaaaattt attataaaaa tcctcatagt tatgatctat ataaggatta 3258061 tgtaacaact cttttaccgt atctataagt tcttcacttg tttgaagcaa gtttcctggc 3258121 gttttttgct gaaaattaaa gtaaaaacct ctgatacagt ctctataagc cgggagatca 3258181 tacacaaaaa atacaaggtt tttttaaaaa ttcatattat caaaaaagac agaagaataa 3258241 tccataatca ataaatcact aattaaatat aaatctcgaa tatctttatt taaagaaaca 3258301 tcgttcacaa aatatttata tttccctaat taaattgttc tgaaactgga taataccatt 3258361 cttacaagaa taaccataga gtctccaagg ttccctcttc atttcctcta atcaaattaa 3258421 agttaaattt atactggcca gctttcttaa aattcattat cccgcaaagt tggtgcatat 3258481 aaaattattt ttctttaatt ccttatttga taatgtagaa ttggtagggg attgtagcta 3258541 aactgtttcc agaatagctt tcaaataaaa ttaatttatt gtttcttggc agaaggacaa 3258601 aaattttaaa caaaactgaa taaactctaa ctagtaaact tctgcaattg gttataataa 3258661 aaatttcatc agtgaactcc ttaaagagtg aagattaata tttacgcaaa caagaaaaaa 3258721 agaagcaact gaatttactt caagcctctt ttagttagtg cttctataaa ctagccatat 3258781 cttttctgat ttgggtagtt gaaatgcctg ctattcttgt aaggtaaatg gcctcatagt 3258841 attcctttgt agacaatcgt acgattaagt aatcccaggt tcttttgctc tttccagtag 3258901 cttcatatgt ccatagtgaa ataaatcaaa cattccgtac gtatcacttt cttcattaga 3258961 taacatcacc ttccaacctt ttccaactta gaaaaaacaa aaatccttaa ctgattgttt 3259021 atcatttcga catatttttt acgttccatt aataataaac aataatagca tatgttccta 3259081 taaaagttaa ggctctttaa aaatgtaaat catcagcact ttttgacaat atcgttgcat 3259141 tgatgtgtat tttttacaga tctgatatct tatctatact cattacaaca agttttctat 3259201 tccggaagag tcaattcttt ttgtcgcgtt ttcaagtgta atgattttct ttctgctgcg 3259261 tcatttattt tgtacgccct cctcatatta cttcatcgtc aaaacgtgaa ggaattgtaa 3259321 tacgtagttc ctaaaaattt tcgtggtaaa atttagtgaa gtctttatca ggctaaggga 3259381 ctttatctaa actacgaatt acatatggag atatatagat gaaaaggagg gttgatatga 3259441 tataaacgaa aatcaattag ataaaggaaa aactgaacac ttctgaaaaa agtgataagt 3259501 ttctttcact atatcctcca aaaagaacct aaaggtcttg gacatgctgt ctggttcgcg 3259561 cctaacttta tcggcgatga gccgtttgcg tttctgcttg gagacgatat tgttcaggct 3259621 gacacaccag ggttgcgcca attaacggat gaatatgaaa gaacactttc ttctattatc 3259681 ggtgttcagc aagtgcctga agatgaaaca cactgttatg gcatcatcgc cccgctgaca 3259741 agtgaaggcc gccgttatca ggtgaaaaac ttcattgaaa aaccgcctaa agacacagca 3259801 ccttctaatc ttgccatctt aggccgttac gtattcacgc ctgagatttt catgtattta 3259861 gaggagcagc aggttggcgc cggcggagaa attcagctta cagacgccat tcaaaaactg 3259921 aatgaaattc aaagagtgtt tgcttacgat tttgaaggca agcgttatga tgttggtgaa 3259981 aagctcggct tcatcacaac aactcttgaa tttgcgatgc aggataaaga gcttcgcgat 3260041 cagctcgttc catttatgga aggtttacta aacaaagaag aaatctaaac aaaaaggcta 3260101 ttggacattc atccaatagc ctttttttat ttcaacatca aagtcagtgt atgctcttca 3260161 ttatcaactg caaaaacctg atcatctgta ttcacaagaa aacgcttctt gctgctgtca 3260221 tacaatacat cgctatcact taaggatagt gacgccgggt tgataggaga aatgttatga 3260281 aaaataagct ctgttgcttt atcattctcc agtacataac tgattttttc ataatcaaaa 3260341 ttcagcgttt ttctgccgtc agccttattt ccttcagtat aaccattcaa tttcgattga 3260401 atgctggtgc tgctgtctcc taggaatttc agaaagtatt cataggaaga tgctgcgttt 3260461 tgcgagacat aagacgtaaa tgcagtggca tgcaattcag cgtgtttcat gttagttgca 3260521 acagcgctct gtttcacata ataagagtgc ccgtcaaact ttattttcgc tgcttgtttg 3260581 ccttttgcag ctaccgttac ttttgtaccg aatggcagtg taacgtcagc cttctgtttc 3260641 aaaccctgat ccttataagc agccgctttt tcatttgcta taaacccttg cttattgatt 3260701 gcagttaagc gttcctctga cttgcccttt gcatcgccat gatggttctt cacttcattt 3260761 tgcggaatag cgccaaacga agcaattgta cgaagcgggg cattaaagaa catcgttccc 3260821 gccatgaaga cagtcagaat agacaaaata gcaatttgaa tggcattggc cagtgatttc 3260881 ggctttttct tctttttgcg gaaacgggca aacgcttcag gatcttcttt cttcctctct 3260941 tctgtctgct cttttttata tgtctctttt tcttttttcg atagcttatt aaaccagtca 3261001 ataaacgctt tgtactcttt cacaaccgtt tttgtttcat caaacatacg aagctcgcca 3261061 tagtgcatcc aagcaacacg gtcacacatc ttttcaatct gaccgattga gtggctgaca 3261121 aagaaaatcg tttttccttg ctttttaaac tcatttattc tgtctacaca cttctgataa 3261181 aacgtttggt cccccacaga aagagcttcg tcaataatta aaatgtcagg atcaatatgc 3261241 acggagatcg cgaaaccgag acgcgacttc atcccgctgg aatagttttt aaccggctga 3261301 ttaataaaat cgccaatctc ggcaaattca acgatgctgt catacatatc atcaatttct 3261361 ttattggtta accccatcat caaacacttg agccggacat tgtcccggcc cgttaattgg 3261421 ttattcaaac cggcagcaat cgcaatcagc gacggctggc cgttcatttc aatttcaccg 3261481 ctggtcggcg gaataatttt agccagcagg ttagacatgg tcgattttcc tgacccgttt 3261541 attcctacaa agccgattgt ctccccttca tacacgtcaa aggagacatt ccgcacagca 3261601 aaaaaaccat tatccttagc cggaaaaaac aatcctttaa tcttgtccga ttgtttttta 3261661 tacaaatgat actgctttga aacatttcga aacgaaactt ttagtttcat cgtaaaatct 3261721 ccttacgtat taaagaaagt caacaaactt gtctctgaat ttcatatgca ggatagaacc 3261781 tactaacaat aaaaggaatg tgaacaacca aaagtacagc gtgtacttca tgtcatggaa 3261841 aaaccatgct ccatctaaga agctgttccg gaatccttca ataatataga atagtggatt 3261901 caacttcaga acaggcacta attcggggtg gctttgaccg agtttcgcat taacatccca 3261961 aaaaattggc aacaagaaaa acaaaagtct tgttacggcc tgcagcaaaa attgataatc 3262021 tctaatcagc acactgatcg ttgagttaaa caaactaaac gaaaacataa aagcaatcat 3262081 acagatgaag taataaatat attgtaacca atgcacactc gggaacacac cattaactag 3262141 gagtacaatg atataaatca ccatcatgat catataacta aataagttag atgcaattgc 3262201 cacggacggt agagaactaa tcgggaagtt cattttagcc accatattaa tgcgcttaaa 3262261 tacactattt gatccatcaa gtatagttgg actgatgaaa aaccatggga ttaatcctgc 3262321 cagcatccaa ataataaaag gcacttcgcc cgctccggtt gtcacaggac cgccctttct 3262381 aatccccata ccaaatacga accagtaggc cagcatttgg ataagcggat ttaagaactg 3262441 ccataagaca cctaaataat tcatttgata tttagacttg gtttcataag ccgccaatct 3262501 taaaattaaa ggaaatgacg ttatttgctc tctgagtata cgcaacaaat cattcatttt 3262561 ttatcttcct tagacttaat tgtttttggg aatctttctg tttaaaattt gaaagcaccg 3262621 ctgattattg taacagatcc tgcatttttt ttcacttctc aacaagtatc taaaaagctg 3262681 ccgaaaaatc gacagctata cattttataa aataacctaa attattcagc tttaaataca 3262741 gtattaacaa ccttttcaga tgaacgtcct gactctaaat agcaaaactt atcatagaaa 3262801 ggaccaaaag aaaccggaag cttataatca ggcgatgaga tctgcttgat agcctcaatc 3262861 gtttcttcag tagtttttac caaaggacca ggagcttctt tttcaaaatc aaagtagaaa 3262921 ccacgcaact tgtcccggta ggtttcgatg tcagggacaa agaatagcat tggccgtttt 3262981 aaatttgcaa aatcaaagaa tactgaagaa taatcagtaa tcagcaaatc agaaaccata 3263041 tacaattctc gaatatcctc ataagcagaa aaatcatatg caaatccttc aaaaggacct 3263101 aaatcaaaat tctcagctac cagataatgc attcttaaga ttacaatata ttcatttcca 3263161 agttcttgtc taagttgatg caaatctaaa tcgagatcga acttataacg cccttttgca 3263221 tagaactgat catctctcca tgtaggggca tataaaataa cctttttatc acgaggaata 3263281 tttaacctac tctttatcaa tgatattgtt tcctcattat tatcattatg aagaaaatca 3263341 tttctaggat atccagattc aatcattgtc ttgttaaact gaaacgcccg tgtaaagatc 3263401 tcagttgaat aaccatttgg ggaaatcaag taatcccaat tagaagcttc cttgataaaa 3263461 ttccttttat attttttggt gtttgtacca ggcatatgga cttcttccat atccattgca 3263521 agtcttttta aaggtgtgcc atgccatgtt tgtaaatatg ttgtatgact aggtttcgga 3263581 atccataatg gaagccggct gttaacaacc caatactcag ctcttgccat agcgaagagc 3263641 cattttaatg agaggcgatt aatgtaagga attccctttt catcaaaagg cgctgaatat 3263701 tgtttattta cactccaata cattttatac tcagggtggt tttcccgcat atattcgtaa 3263761 atcgctctcg gattacaact gtattgtttc ccattaaaac tttcaaaaat gactgttttc 3263821 cttttaactg gcattctgct agccatcatg aatagagatt tgtatgtttt agtgattaac 3263881 ttgtttctca tttttgtgat cttttttatt tttgatacta atctcttctt ctttccttta 3263941 ataaagtatt tcatccttgt tttcaggcta tagtcgttta ctctgatacc tagagtctgc 3264001 tttttctttt tcttaaagac ttcataacga actggtgcgt tgtttgtttt aataatactt 3264061 actaatcctt ttaatttgtt ttttcgatct cctaaaacaa gagcagtgct gttgaactga 3264121 atatccgttc cttcatcgtc attgcatata tactccataa aaagacgata aacataacgt 3264181 ttttcatttg agaaaggaat ttctttcaaa ggcactttca cttcaaaatc atacagttcc 3264241 ggaacaaaac catctgctct catgttttcc aggccatgtg tttttctttc tagcttgatt 3264301 ggaaattttt cctcaatagg tgtttctcca ccctttttta aaataaggtt caagtttttt 3264361 atccgatatt gattttcgga actcaggtac cccgcataac ctgttatgct tatttcttca 3264421 gagctaatct cgatttgatc aaatctgatg attttggcct ctcttttcac cttaatagaa 3264481 aagttgcctt tatcagttgt ataaggtaaa atcaaaagtt ctgtggtttg atcgacatga 3264541 aaggcgcgct caattgaatt tacttcagca gaaagacgct tcaagagtgg ttcctgctcc 3264601 gcatcttcat atttttttcg aaattcgaca taaaaatcat atgtttgtcc catttcaaca 3264661 ggcataggca aaacatgagc atttatctca gttttatact ctaatgagcc agtgttttga 3264721 agcggaaatt cagattccgt tcctgaacgt ctctctttca gctttaaaaa taactggtaa 3264781 tcctctaaaa attggtgttc tgaatcaatt gagattaaca attcaagact tcctaaattg 3264841 tttttcaagc ttttcaaaat acatttaatc acagtgtttt caatcattac ttttttctgc 3264901 tcctctgtat aaaagctctt tcctttttgc ttccttttat tagtgtcaac tactaaggac 3264961 attaactctc ttttatttcc gtgaccctcc aagagaaatt gcctttaact gttgtatagg 3265021 gctctactct atagccatta ttagtatcta tactgtttcc tgacaatttt gtttcttcac 3265081 tcgaaagtct tcgcattgtt ttaatatggc catttgcatt gaaaacaata taaaaatcaa 3265141 taacttgggt tttattagca gctatctttt caatatttac atctttttcg agatcaatta 3265201 caaacagttg atcattttgt aagtttgttg aaataatttc agccttattc tttctgtcca 3265261 agcccactaa acgtattttt ttaatatcat tatgatcaaa attctcaatg tcaatttcta 3265321 ttttagtttt atcaaaatcc tcagtatagg aactaataga aggatctttt tttccaacct 3265381 ttttagagaa cttctctctt tctattcgca cctcaatcat ctgattaaga gcaaaagccc 3265441 aattttcaat atagttgggt cttgaatatt tttcagccat tttaaaagct tgttctgaaa 3265501 atttttgatg agtactttca tctttcatca aagagataat agcttgaccc aatttctcta 3265561 tattatactg ttcaatgaca tatccatttg ctccgtcagt aactaagctc cttgctccgt 3265621 aatcataatc gtatgttaca actggacatc cattgctcag tgcctccata tttgatagac 3265681 cgaacccttc aaaatgagag gttgaaatgg ttagccaagc tttttgaaac tctgagtcag 3265741 ggttatccgt atagcctttc aaaaagacat tgttctgcag tttggtatct tcaatttctt 3265801 tttttatttt ttcgaaatct tcacccgatc cgaatatatc aagttttgct tcaggaattt 3265861 ctttcacgac taaactaaat gcttttactg catgtatcag atttttcata gatgcaagtc 3265921 ttgaaataat gacagctttg tatttttcac tcggcacatt caatacagcg ggatcaagag 3265981 gcttatcaat tgtatgcgga gtaaagaaaa acgtctcttg ttcccctgaa atcaatttaa 3266041 aatcttctag ctgctcctca gttataaaaa agacagcatc caaattatac atctgactaa 3266101 atacttcttt atagcgaccc ttaatttgat atttattgct gccgtaatgc ttgttatgaa 3266161 taattgctcc ataataggaa gaaggtgatt ttttcacttt aaagacatgt ttgtcttgcg 3266221 gtctgctgtc cactaaaaac aacttaggtt tatcattttg tttttgcaga tattctatcc 3266281 aatattgacg cagttccgat tcatctttta cttttatctc accctcaagg gagtaccaaa 3266341 taatatgaga taattgaaca tctttttctt cattgttcca tacatagagt ttgtctaaat 3266401 atacttgatt ttggtcatta atatattcct gcagatacat cttgtttagc tgcacatcat 3266461 aatgagtaac gagaactaag tttccgttct tcgtatattc ctctctcttt atgagctggt 3266521 ttttatcatt ccaatagtcg acgtaccgga tagtttctcc atctccgtag taaactacag 3266581 acatttcatt gttcttctta ccaaacaatc tcaacagagt ttttgcaaat ttccccattc 3266641 caacttgctt ttttatctgg tcaaggccta tcctttcttc gtatgatctt ttcccatttg 3266701 ttctaacact taaaaaatca tcgaatagat taataacact tgtgaatttt ttatcaatct 3266761 taccgttgct gtacaattca tcaatttttg aagacaactc taaatcaaaa cgaaacgtta 3266821 agaaaaaggt gttttggtta cactcttctc caaataattt tgaacgcaat aataatgatt 3266881 tcgtcagacc gccataatta cttggcagtc caccagagat aaaataataa tccatgtcag 3266941 gaatttgttt tatattagat tcactcaccg catgtaaaga caatttttta ctccctttcg 3267001 gcatctagaa tatatgatca ttgaaattta tatctacccg gatactttag tcacaaaaat 3267061 caatgtaagc atcaaaaagt acttcttatt tcaataagaa gtactttaat tagatattga 3267121 accaatgata tcaggatcct aaattataaa ccagcaattt cctctttgat ctttgttgta 3267181 gagatgcctt ctgttcttgg gaggtaaaca acctcacact gatctttgag aaagtcaaat 3267241 ttaccttccc agtcatcccc cataacaaaa acatcaatat tatgatcaat aatatcttgc 3267301 tttttttgct cccaattctt ttcaggaatt acttcgtcca catatcgaat ggtttctaaa 3267361 attaatttac ggtgctcata gctgtgataa gctttttttt gcttttgtaa attgaattca 3267421 tccgttgaaa tagcaacaac taaataatca ccaagctgct ttgcacgctc aagcaattta 3267481 atgtgacccc aatgcagtaa atcaaaagtt ccatatgtga taactttttt catttaaaga 3267541 aacgctcctt cctaatgtta aacactatta aaaacactac tgacgttagc gattaaattc 3267601 taaaaacctg tttgtattcc ttatatcgac atatttctcg tatgtcttca ctgatcatta 3267661 attatagcat accgcctaaa aaaggttaag tactcatgag gagaaaaaca ttccaaaata 3267721 tgtaattaca ctcagactcc attggcacca aggtctgttg ttcattcgtt cattcaattg 3267781 taaaattgga aacatattta aatttaatgt aaagataatg ttaatccttt gttgaagatt 3267841 tatgttaaaa tataaggtag cttgattttg cttttagaaa ctctcggttt ttaactatat 3267901 aaatagaatc ttaaaggaag gaggagccag acatgcaaac agagactatt cacaatattc 3267961 cttatgttaa cagtaactta acatcattta tcgattacct agagaaacat tatattgatc 3268021 aaaagattgg tgctgtcatt tccacagtca accctgaaat tgcatttgca gctattaaag 3268081 atcgggacta ctttgatgta ctatcttctt caaacttcat tttgcctgat gggatcggtg 3268141 tagtcatgat gtcacgtttg actaacaaca ggcttcagtc ccgaatcgca ggttacgatg 3268201 tttttaaaga acttctgggc gttgctaaca aaaagaaaaa acgcatattt ctgtacggtg 3268261 cgaagaaaga tgttataaaa ggtgttgtat ccaaaatttc ttctgaatac ccaaacatta 3268321 aaatcgcagg ttattcagac ggttatgttc aagatcgcac cctagtggca aaacaaattg 3268381 caagagcaaa tcctgacatg gtattcgtag ctttagggta tcctcatcaa gagaaattca 3268441 ttcataacta cagacacttg ttccctaaag ccgtatctat aggtctagga ggaagctttg 3268501 atgtatttag cggtaatgtc aaacgggccc cttcctggat gatacgttta aatttagaat 3268561 ggttctaccg gttaatcttg aatccatggc gatggaaaag aatgcttagc atcccaaaat 3268621 atgctttaac ggttttaaaa gaagaaaaaa acaaaaaaac tttctatcca aagcctgaaa 3268681 aagatcatac aaaacagatt taaaaacaaa actttcaaat aaatggatga taaaaatgaa 3268741 aataagatca ctactggcga attgctattt gtatttttta tcagcaatcg ccttttttct 3268801 gcaatgggtg aaacctgaaa gcaaagtgac cctcctgatc tcattcgaag caaacgcaaa 3268861 agcgattctt gaggaatatg aacaaggaca atactcttat aaacttaaca tcctgtatac 3268921 ccagcaggcc tctgctattg ccgagagctt cccgaatgta gatgcatatt tattacaaga 3268981 aaaaaaccct atccatctca ttaaagctgt atacctaatg tttaacagta aagtgatcat 3269041 aacagataat tactttctat taacaagtgt gttaaataag cggaagcaaa cgaaatgtat 3269101 ccaagtatgg cacgcaaatg gctcactcaa aaaatttggt ttggaagaca ttacaaacat 3269161 gcaacggacg aaaactgata ttaaaaggtt ccaaaaagta tacagttcgt atgattattt 3269221 aactgttggc tcagaagaga tggcaaatat cttcaagaaa tcatttggaa taaaggataa 3269281 ccaattatta aaaataggtg tacctttaac agacccttat taccgagaaa acaagaaaaa 3269341 aatttcagat actctaaaca tacaaagaaa aaaaataatc ctctatgcac cgacgtttag 3269401 agattataat atgcaatcaa ttcaattgcc ttttacagaa gaacaattaa ttcatcagtt 3269461 aaaagaagaa tatgttttat ttgttaagct gcatcccgcc attcagaaca atattgatat 3269521 taaatattcc agtgattata ttaaagatgt ttctaactat gccttgtttg atctactcat 3269581 ggctgcagac atattaatca ctgactattc ttctgttccc tttgaatttt cgattttaaa 3269641 taaacccatt cttttttata cttacgattt aaaactttat caacagaagc ggggattggt 3269701 tgataattat ctttccataa tacctggaag agcctgctat gacagtgaat cattaataaa 3269761 tgaaattcaa accccattta attattccaa aataaaagtt ttttccgata gatggaataa 3269821 gtattctgat gggaattcaa gccaaaattt attgaatttc atcgaaaatt taataagcta 3269881 aatgatgaca cttgttcaaa acagaacaag tgttcttttt tctattgaat accgaacgta 3269941 tgtttgcttt aatgtaatta gttgcttatg gcagcaaata ataatagagg tggtaaattt 3270001 atgagaaaaa aagaactgtt tgatttcacc aacatcacgc caaaattatt tactgaacta 3270061 cgtgtagcag acaaaaccgt acttcaatca ttcaatttcg atgagaaaaa ccaccaaatt 3270121 tatacaaccc aagtcgcaag tggattagga aaagacaaca cccaaagcta tcgcataact 3270181 cgtctatctc ttgaaggttt acaattagac agcatgctgt tgaaacatgg aggtcatggt 3270241 acaaatattg gaattgaaaa ccgtaatggc accatttata tttggtctct atacgataaa 3270301 ccaaacgaaa cagataaaag tgaattagtt tgtttcccat ataaagcagg cgcgacttta 3270361 gatgaaaatt ctaaagaact tcagcgattc tcgaatatgc ctttcgatca tagggttaca 3270421 cctgctcttg atatgaagaa tagacagttg gcaattagac aatacgatac aaaaaataat 3270481 aataataaac agtgggtgac aatctttaac ctggacgatg caatagcaaa taaaaacaat 3270541 cctctttata ctattaacat tcctgacgaa cttcattatt tacaaggttt ctttttagat 3270601 gacggttatt tatattggta tacaggagat acaaacagca aaagctatcc gaatctcata 3270661 actgtatttg attccgataa taaaatagtg ctgcaaaaag aaattactgt tggcaaagac 3270721 ttgtccacca gatatgagaa taacttccgt gaaccggaag ggatctgtat gtacaccaat 3270781 cctgaaactg gggcaaaatc attaatggtg ggaattacaa gtggaaaaga aggaaatcgt 3270841 ataagcagaa tttatgcata ccattcttat gaaaacttca tgaatcatgt acctatgctt 3270901 cgatcccctt tattaaaaac cgtggggcac caagatacac ctccagaaag atttcaacca 3270961 tttattcaaa ccttcatttt agagtataat gctcaaaaca aaaaatggat ggttccgact 3271021 tcaggttatt taccatctta cacatcaaat ttagtccgaa atattactat caatgcagat 3271081 ggaaacttgc aagtcacatt aaatgaacgc tatattagtt tactgcatca atcgatagaa 3271141 ggagatttcc gcttaaaaca aaaggatatc cgaatgggat cctggtattt tgccggcgga 3271201 gaaaaatcaa atgtgcttga aataggtttt atgaaaggga gtacaaaaat cagacccgat 3271261 gatgcagcca tctcaaatgc ttcaagaatg agtattttta tgattgttgc ggacaagatt 3271321 gaggtgtgat aatcaaatag gctgtagcta tttaatagct acagcctatt tgcaactttc 3271381 taagtttttt atcgatattc cggaacatca aaataaagtg tataaccgtc cagcaatgaa 3271441 tacaggctgt acatgcggtt tacttgtttg tacgcccagc cgatgtctgt tgcgtattga 3271501 tgtgtcgctg tagctgacca tctcattttg tacagtgtgt cttgattgta agctgtgttg 3271561 tggatatacg atgagcctat gaatttagct ccgccgataa tggccgcttc tggtgtgaac 3271621 cagccctgct cgtacgcata tttggctccg tagtaattcg gattgctgtc gtatgctcca 3271681 attccataca tgttgtatac ggtttttccg ttataggtta atccattggc taaagcggat 3271741 gtcccgtttc ctgtttccag aagagcgtgt gagattaaat acagttcgtt gatgctatat 3271801 tgattggcgg catcgataaa tgcctttgct ctccctgtca ggatgccttt acccgcaagc 3271861 actttctgat ttacctcagt aacgctgaga cccgctgtct gtgacagctt gagaaattgg 3271921 aagtagtatt tgctgtctct ggaaaagtta ttcggatcca cgtattgaac tacttcatca 3271981 ctgcttgcgt ttcgccagcc caaattgatc ttagcccagc cgtttatctg tccgatgact 3272041 ttcactttat cgcctttttt aaactggccg atcacgtttg tcgggctgac ttccggcgtt 3272101 gaccggatat ttagtacatc agccgtaaca gttgatgttg ctgtattaat gtacgtgagc 3272161 gatacgtaag ccgctccgtc tgtttgcgga cttactgtca tttgtttttg gaccatatca 3272221 cgaagcgaga gattgtagtt tgttttcatg atttgcgggc cgtttttgat cttcacgata 3272281 gatgatgtcc atccgtataa ttgttttagc ttcgttgatg ccgcagcagc tgtatcattg 3272341 cctgtgaact gctcatttac gctgatttta taaagcgtat tgcttttcgt tgtatagctc 3272401 ggggttacac ttttcgattt aagataggtt aacccattgt tcaatgcggt tttgctgcta 3272461 agctgtgttg tcacgatttt gtattgtgta tatgcagtct ggcctgtttt tgatgttgtg 3272521 actgcgatat gattttgttt gaaaaatgtt aaaacgcggt caatctcttc ttggctgatg 3272581 atagcttcag ttgtgatttg atagctgctc gcagctgtct gaccggtttt ctggcttgct 3272641 actgatatat gattcgattt gaaaaacgtg agtgcctgat tgactttcgt ttgatcaagc 3272701 agagattcgg ttgtgatttt aaacgtgtca gctatttgtt ttttgacgga tttcgcagaa 3272761 gcacttagct gatttttctt taatatgttc aaaccctttg tgacttttgc ttgatctgat 3272821 gtttcttctg agatgagctg atattgattt tctgctgttg atccagctgc tgtttttgca 3272881 gcttttactt ttttctgagc aaagaaggct gctgctttgt ttgcttgctg ctcgcctaaa 3272941 atctttgccg tcgtgatttg ataagctgca gacgttgtcg tttttttgac gctggatgac 3273001 gtgtaatgcc attttttctt tttaaagaaa gtgtctattt tttggagctg ctgttttgtt 3273061 atacccttca tattcacggt atatgatgtg ctttttccaa cctgttgata actgccggat 3273121 acgccagtgt ttttcttgat ttggctgatg gcgtccttta ctgtactcag ccctttgaaa 3273181 taagctgatt ggacattgta tgactcaacg gttgtttttt gattgatgga cttgtagctg 3273241 cctgtgatgc cagtgctctg tttcagctgc tgcaatagag ttttggcatt ggcttcacct 3273301 gaaatggcgg cagttgtgaa cgtataatag gcttgccctt tcactgtttc ctttaatgat 3273361 gcctgcagcc cagattcctt ttggaaggcg tttttgatct gcgctgctct gctgtctccc 3273421 acgattgtgc cagactgaat ggttgtgaca gacaccgtgt gtgtgatggg ctgatacgag 3273481 cttttaatcc ccgtttgctt ggccaggctc tggataagcg ccttgacttt tgtctcatca 3273541 gcaatgtctg atgtcatgac gttcatatag ggctgagctg ctccgtaagc ttttacagcg 3273601 ccagccactc ccgtctcctg tttcagcttt gctaggatag tgttggcctg tttttctccg 3273661 gagatggcac ctgacgagat ggtgacatat ggctgtttgc ttccaacagg acttgacgtt 3273721 cctgtaattg atgtctgttt ggcgagtccg ctcagtattg ctttcgcttc tgattcgcta 3273781 tgaatgcctg aggcggaaat ttggtaggtc gttgttgtgc ctgaagcctg ataggatgca 3273841 tcccagccag tatctttttc cagtttggcg acagcttgtg aggcttggct ttctgtactg 3273901 aacgtattcg acggctctac tttatatagt gagtagtcgg tatacgcggc tgcctgggca 3273961 gaaccagaca tggcaaaaaa ggcaagggac gcggcggata gaagcatagg tgcgattagt 3274021 ctctttttca ttccttctcc tctttcttat tctatgagta tataaaacta gtttatttat 3274081 cggcacgcgc atgcttcatt tataggtgaa tcacttccat tttctaataa aaaaacttaa 3274141 cctcgaagtg agattaagtt taaatatgag acacgataag ggtacaagtt ccttttatcg 3274201 taaaatcggg catttgagcc ggcaaaataa agtgatcacc ttttttgagc ggacatgttt 3274261 tgtcctcata cttgagcaaa ccgcttcctt ctatcacgct gcaaatcaga aaggattcat 3274321 cctgagccat ttcagcttcg ccattgatgt cccatttata aaccgaaaaa tattcccctt 3274381 ggacaaatgt tttaatggtt attccttttc ttgattctgt cgattcatct atatacccgt 3274441 ccacatgggg aaccgtggcg gcattgaccg ctttggcaaa atgaagctct ctcggacttc 3274501 cgttgctatc aagacggtca taatcgtaca cccggtatgt ggcatctgaa ttttgctgag 3274561 tctctaaaac aagggccccc ttgcacaatg cgtgcagcgt tccgctcggc acataataga 3274621 aatcacccgg tttaattttg attcttcgca gcaggccctc ccagtcaccg ctgttgatca 3274681 ttgtgacaag ttcggttttt gagcgggccg tatgcccgta aatgatttct gcgttttcct 3274741 tacagtcgat aatgtaccag cattccgtct tgccgagttc tccctcttcg ttttctccgg 3274801 catagtaatc atcagggtga actttaattg acgtatcttc cttcacatcc agcagctttg 3274861 tcagaagcgg aaaccgatcc ccctctacgc cgccgaatac ttcacggtgc tcttcccaaa 3274921 gctcgatcaa tgtctttcct ttatacgggc catttgcaac agtgctcggt ccttttggat 3274981 gagcggaaat ggcccagcat tcccccgttg attctgaagg aatactgtat ccaaatctat 3275041 ctcgtaaagc ggttccgccc cagatttttt ctttaaacac aggcgttaga aaaatcggtg 3275101 attgcgtcat gatccgtacc cctcccctgt aaataactga tcatcatttt cccggtgcgc 3275161 ccctcttaca aacgcccgta taagctgcct ttttcctatg acaacatatg tacaaagcat 3275221 catcttttca ttaccccttc aaagaaaacg cttcctatct attatatcac gtcgaaaaga 3275281 agctttgttt cagccttttc ctcgataaga ataattctcc ttttttgata caaattaata 3275341 aaaaccgtca atatgtttaa gaaggagaga aactatgcaa atcgactctg atctccagaa 3275401 caatttagac acactgaaaa aaacattggg acaaaacgac gatatgatgt tttatacatt 3275461 tgctttcgga gatagcagac aaaaggcgtg tttactgtat attgacggtc tgacagagaa 3275521 taaaatgctg gcgcaatacg tcatttctcc tttacaaaaa gaggcgttgg cccataagga 3275581 atgctcgatt gaagacttat ccgccttttt tttcggcttt caccacagcg ttgtttctac 3275641 aatgaaagaa atagagcagc tcgttttttc agggcaagcc attttgctcg ctgatggcta 3275701 tcgcggagga ttagctttcg acacaaagtc agtcgcaaca cgcagtcttg atgaaccctc 3275761 ctccgaagtc gtggaacgcg gccctaaaat aggatttatt gaaaagctgc ggacaaacac 3275821 ggcgcttttg cgtgaacgga cgagtgatcc taatctcgtc atcaaagaaa tgacactcgg 3275881 aaaaaggacc aaaaagaaaa tcgctgtcgc ttatattcag gatatcgccc cagattatgt 3275941 cgtcaaagaa gtgtttaaaa ggctgaaatc agtcaatata gataatttgc cggaatcggg 3276001 gacgcttgaa cagctgattg aagacgaacc attttcaatt ttccccacaa tattaagcac 3276061 agaacgaccg gaccgggtcg aaagttctct attagaaggg cgagtgtcca tattagtgga 3276121 tggtacgccg tttgctttga ttgtaccggc tacggttgac gaatttattc attcgcccga 3276181 tgattacagc cagcgctgga tcccaatgtc acttgtacgc cttcttcgtt attccagcat 3276241 cctgatcacc atttatttgc ccggtctgta tatttctctc gtttcttttc acaccgggct 3276301 attgccgact agaatggcca tttccattgc aggcagcagg cttaacgtac cattcccgcc 3276361 ttttgtagag gcctttatca tgatctttac gatcgaattg attcgagaag ccggattaag 3276421 gctgcctaag ccgattggac agacaattgg ccttatcggc ggcgttgtca tcggacaggc 3276481 agctgttcag gcgcaaattg tcagtgcgct tatggtcatt gtcgtttctg tcacagcact 3276541 ggcatccttt accgttcctt catacgccta taactttccg ctgcggatca ttcggatcgg 3276601 ggttatgata agtgcaacag cgcttggcat gtacggcgtt ataatggttt atctgtttgt 3276661 gatcggccat ctcatgcgcc tgaaaagctt tggccaggat tacattatcc cgatcatggc 3276721 gcagcctgga caggatttga aagacacagt catccgtatt cccacgatgt ttttaaaaag 3276781 aagaccgaca cgaaacgatc ccgaagataa catcagacaa aggtgatggc tatgaggaaa 3276841 tcagagcata aactgacatt tatgcagacg ctcattatga tcagcagcac attgattggt 3276901 gccggggtgc tgacccttcc ccgctcagcc gccgaaaccg gcagtccgag cggatggcta 3276961 atgatactgc tccagggcgt tatttttatt atcatcgttc tgcttttttt gccttttctt 3277021 caaaaaaaca gcggaaaaac tctttttaag ctcaacagca ttgtagctgg aaaattcatc 3277081 ggctttctat tgaatttata tatctgtcta tatttcattg ggattgtttg ctttcaagct 3277141 cggattttgg gagaggttgt cggattcttt ttgttgaaaa atacgccaat ggcagttgtg 3277201 gtgtttatat ttcttgcagt tgccatctat catgtaggcg gaggcgttta ttcaattgca 3277261 aaagtatacg cttatatttt tcctataacc cttattattt ttatgatgct tctgatgttc 3277321 agctttcgct tgttccagct tgattttatc cggccggtat ttgaaggagg ctatcaaagc 3277381 tttttctctt tattcccaaa aacattatta tatttctccg gatttgaaat cattttttac 3277441 ctggtcccct ttatgagaga tccaaagcaa gtgaaaaagg ctgttgctct gggcatcgcg 3277501 acttccacat tgttctacag cattactttg ctcattgtga ttggctgtat gactgtggct 3277561 gaggcaaaaa cggtgacatg gccgaccatt tcccttattc acgcattaga ggttccgggt 3277621 atttttattg aacgatttga tttgttctta cagctgacct ggacagccca gcaatttgcc 3277681 tgtatgctcg gatcctttaa aggcgcccat atcgggttaa cggaaatctt tcatctaaaa 3277741 aataaaaaca atgcatggct gctgactgca atgctggctg cgacgttttt cataacgatg 3277801 tatcccaagg acttgaatga cgtgttttat tacgggacgc ttcttggata tgctttctta 3277861 attgtgatta caattccatt cttcgtctgg tttttaagct ggatacagaa aaaaataggg 3277921 agggggcagc tgcaatgaaa acagcatcaa aattctccgt catgtttttt atgctgctgg 3277981 ccctctgcgg ctgctgggat gtcaaagata tcgagcaact atccttcgcc agagggctgg 3278041 cgatcgatga gacaaatgat caccagtaca aactgacgta tcaaaatctt cttccccaaa 3278101 gcgaagacag ccaagcatcc ggaaaacccg aatttgttaa tgtaacgtcc cacgggaaaa 3278161 cgattctgga agcagtcagt gatgtatcca tcaaggaccc tcctgtttat agcgatcatt 3278221 taaaagtgat ccttctggga gaaaaactga tgaggaatca aaatgtagac caagtcctca 3278281 accactttat ccgggatgat gagctgcggc gaagcagcta tttgatggca gccagaggga 3278341 atgcagctga tgttttcaca aaaggaaacc ccaatcagca gcagccgatg ccctccgaaa 3278401 aactgattga tttgacaact cacagcggat ataacggtaa gattatgata ccgctgcgca 3278461 tcggaagagc ttctgtctac tctcagaacg ggtacagtta tcttattcaa gccgtgaaaa 3278521 acgaaaaggg aaaagccaag tatgacggag caggcattat caaaaggggc agcaataaac 3278581 tcgttgggtt tctttcagct gatgaaaccc aaacactgtc atgggtcatg gggacgatcc 3278641 aaggcggtgt catgccgacg acagataaag gacatccgat tacgtttgaa attaaaaagt 3278701 cgaaaacgaa aattaagccc gtcattgaaa acggaaagcc tgtctttcat atttctgtta 3278761 aaacgaaggg catcctgaca gaagaccaaa acccgaatga aaactccttt agcaaaagtt 3278821 atttgcacag gctggaaaac atttttgaaa aaaagcttga acgagatgta aagcaggtga 3278881 tggataaact gcagcacgag tataaaaccg atccggtctt tttatcagac cacataagga 3278941 ttcaacaccc tgactactgg aataaagtaa aagggcattg ggatgaaata ttttctgaga 3279001 ctgattttaa gtacgatatt tcttttaaaa tcattaactt tggcacggtg ggaaagtaag 3279061 caatcaaaag ggtgcgcatg atcgcgcacc cttttttatg ttccgacagt ctgctgtttt 3279121 ccggccgctc ctccctgtcc gtttttgtcc cgtaaatcct gctcaatttc ttcaaggctt 3279181 cttccctttg tctctgtcac tttaaatcgg acaaataaga acgccatgat accgatcgcg 3279241 gcataaatca ggaataaata actgattccg atcgcttcca ttaatattgg ataggttaat 3279301 gaaacaatca gtgtcccaac gtgcaacatt aaggtcgaaa caccggtccc gattcctctg 3279361 acgtgaagcg ggaacaattc aggaagcatc acccacacaa ccggtcccca gctgaccgca 3279421 aagacaacga taaacacgcc taaacaaatg acggtcgtcc atgaggcagc cggagtgtta 3279481 tcgaaaaaga gatttactaa agcgagaacg atcaagctga tcaccatgcc cgcattcccg 3279541 aatagcagta acggctttct tccaatcttg tcgatgattt taatcgctac taatgtcatg 3279601 agaacattga ctgtgccgat tccgaccgtg cctaaaatcg aagcggagtt tccgaatccg 3279661 acgtttgtaa aggtctttgg cgcatagtag atgatcgtat tcgttccgat aaattgctgc 3279721 aaaaaagcga gtcccaaacc tgcaataagc gctgggcgca cccatggatc gaacagctcc 3279781 ttcagaccgc cttcatcctg cttttccgct tcttttatat catgtatttc ctgatcaata 3279841 tcttttgtgc cacgcaattt ttcaagaatt ttcttcgctt tgctttcttc gccattcgtg 3279901 aacagccagc gcgggctctc cggcataaac aaaatgccaa taagcaagag caatgacggc 3279961 acagcagcca atccaagcat ccagcgccac gcttcggcat cggcaaatat gtaattgaca 3280021 atgtaagaaa gaaggatgcc gaccgtgatc atcagctgat tcagtgatga cagcgccccg 3280081 cgtttatgtt ttggcgccag ttcagataaa taaaggggta cgattgtcgt cgatgttccg 3280141 actgcaagtc ccaaaatgat gcgaaacagc accatgactc ctgtatttgg ggccagtgcc 3280201 acaccaagac cgcctataca aaacagcagc gcggctgcca taattgcttt ttttcttccg 3280261 aaacggtcag tcagcttgcc ggccgctcct gagcccaata tcgccccaac cagcaaggag 3280321 ctgacaacaa gaccttctgt aaacgcgttt aagcctaact cctttttcat aaataaaata 3280381 gctccggaaa tcactccggt atcatagcca tataacgcgc ctccaagagc tccgaaaaaa 3280441 taaagccata tatttgactg ctttttcata aagatgactc cctttctcca tcagctgcaa 3280501 tgacattgtc tgtgggattt ttttagaaat cttttagcct ctttttccgg ccattaaacc 3280561 tttttatttt tctgatcata agttttccaa tcatttactt gtattttttt caatgtcgcc 3280621 gaaacatttt acctgctgcg gcgtccaata taaggtgatt cagtacatta tcgttatcaa 3280681 ttttcaaaaa caagaactta taaatatagg aatatttatc gaaaaatgtc tttcgagtag 3280741 ttgccccatg gcaaatagaa tggtacgctt caaatattaa agaaacgtga ggtattgata 3280801 tatggaagaa cgatcacagc gcagaaagaa aaaaagaaaa ctaaaaaaat gggtgaaagt 3280861 tgttgccgga ttaatggctt ttttagtcat tgcggcaggc tctgtcggcg cctatgcttt 3280921 tgtaaagctg aacaatgctt ctaaggaagc tcatgtcagc cttgcacgcg gagaacaatc 3280981 tgtaaaacgg atcaaagaat ttgatcctgg aaaagattct ttttctgtat tgctcttagg 3281041 aattgatgcc agggagaaaa acggcgagac cgtcgatcag gcaagaagtg acgcgaatgt 3281101 gctggttaca tttaatcgga aagaaaaaac agctaaaatg ctgagcattc cgcgtgacgc 3281161 ctatgtaaac atcccaggcc acgggtatga taaattcaca catgctcacg cttacggcgg 3281221 cgttgactta actgtgaaaa cagttgaaga aatgctggat attccagtcg attatgtcgt 3281281 agaaagcaat ttcacggctt ttgaagacgt cgtaaacgag ttaaatggcg tcaaagtaac 3281341 tgtaaaaagc gataaagtca ttcagcaaat caaaaaagat acaaaaggta aagtcgttct 3281401 tcaaaaagga acacatacgc ttgatgggga agaagcgctc gcttacgtaa gaacacgtaa 3281461 agcggacagt gaccttttac gcgggcaaag acaaatggaa gtgctgagcg ccattataga 3281521 taaatcaaaa tcattgagct caattccggc ttatgatgat attgtggata cgatggggca 3281581 aaatttaaaa atgaacttat ctcttaaaga tgccatcggc ctgttcccgt tcatcacttc 3281641 attgaaatca gttgagtcta ttcagctgac gggttatgat tatgaacctg ccggagtcta 3281701 ttatttcaaa ttgaatcagc aaaagctgca ggaagttaaa aaagagctgc aaaacgattt 3281761 aggtgtataa tgaacgggat ggcgattacg ccatcccgtt ttacatattt ccttgttgaa 3281821 aattatcaaa gtaacgttta gccttaattt atatggatta tgtttcacag gcaagctgaa 3281881 catactacac gaagcagctt catttttaag gaggttcccc tacatatgaa atgtattgcg 3281941 attgatctag acggaacatt actgaataaa gaaagcgtca tttctgcgga aaacagagag 3282001 gcgatcaagc gggccgttga tgccggcatc ctcgtcacca tttgcacggg aagagcgaca 3282061 tttgatgtaa aagcgctgct ggatgacttg gacatcccta tcattgcagc taatggcggt 3282121 acgatccacg acacgggtta ccgtttgatc agccggacat taatggatca ggaagccggt 3282181 aaagcgattg ctgattactt actttcaaaa aacatttact ttgaggtata tacagatgac 3282241 catctgcttt ctccttttga cggcgaagct aagctgcacg cggagcttga cattctaaag 3282301 agcgcaaacc caaacgagca gacggatgac ttgtggcaag gagccatgac tcaattcaaa 3282361 cagtttggca ttaaaccaat ccctcatatc gaatcggttt ttgacggcgg tgaaaacatt 3282421 tataagcttc tttgcttctc ctttgatatg gacaagctga aacaagcgaa ggaagaactg 3282481 aagcatcata aaaaactggc gcaaacctct tcaggaaaac atattatcga aatcctgccg 3282541 gcctcgtcag gaaaaggacg cgcgttaaca aagctggctg acatatacgg aattgaaaca 3282601 caggatatct atgcgatcgg cgatagtcca aacgatttgt ccatgtttga agtcgccgga 3282661 caccgtatcg ccatggaaaa tgcgattgat gaattaaaag aaaaaagcac ctttgtcaca 3282721 aaaagcaatg acgaaaatgg tgtggcctac tttatagacc agcttctttc ggggcaatat 3282781 gcataaagaa aagactccag agattggagt ctttttcttt tattgcaccc gtatacttcc 3282841 tgcgtattta tccttccaat atgtgctcgt gttcatattg gtaatggtca cgccgtttga 3282901 taatgtgaca tgaacaactt gtccgtttcc gatatagatg gagggattta agcttgttga 3282961 ttgaaagaac acaatgtctc ccggcttcag gtccgccttc tcaatcttag ttccggcatt 3283021 gtactggctt gttgcgtatc gaggcaggga aataccggct gctttctggt atacatattg 3283081 gacaaatcca gctgtatcaa atcccgtctc aggtgttact ccgccctgtt tgtaaggcac 3283141 ttctccgaca taaagcgtcg cttcggaaac aatcggattt tctttcggga ttgtcaggtt 3283201 gtcaaatcgg cgaatacccg tcatcttcga tttccagtaa tcctctgaca aataggaaat 3283261 ggttactttt tctgaccggc ttgcctgaat gaacctgcct gcgcccgcat aaatgcctgc 3283321 atgtgaaatt cccgttttat acgtattgct gaaatagacg acatcaccag gctttatgtt 3283381 ctgaggggct accttctcgc ccactgccca ctgctgttcg gctgatcgcg gtagataaat 3283441 gccgagtgcc tgttgaaaca catattgcac aagccccgag caatcaaagc cctctgacgg 3283501 cgtgcttccg ccaaacacat atgggacacc gatatatttt tcggcctcct gaacgacagg 3283561 aacatcagcc gttgccggat cggcagcgat tcgtctcgcc ccgatataag ttccgctcca 3283621 atagctgctt tttttgtaat tggtgatgat aacccctttt gactgtgtac tgtgaaccat 3283681 ttggccgtct ccgatataaa gggcgtcatg tgtcggaaca gtgccggtgc ttccctcttt 3283741 cttgaaaaac aaaatatcac ccggcttcag gttttccggt tttacagctg ttccgatttt 3283801 atactggtcg tttacagatc tcggcagatg aatatcagcc ttactgaaca catattgtat 3283861 caatcctgat ggatcgaaac cctctttcgg cgtttccccg ccatatttat actgatatcc 3283921 aagcaggttt tttgcttcgc tgacaatcaa ttctgatgat gtatcagctt ccgcaatctc 3283981 cgcttttgtc ataattggaa ccaaaaaaca aatgataacc gccacaagca aaaacttctt 3284041 ccagtttgcc agtgtgttca cttttattat ctcctcctct ttttgcagtt ttaacatcgg 3284101 tatttttttg aatatgttaa gagacttttt aatattttta cagaatgaat atgctgggca 3284161 aataaaaaga gagtgtctca tcagacactc tcttttttga attatttatt ggcgtttacc 3284221 ggttcttcct gctgctggat tttattcatt tccatatcaa tcttctgttt ttcctgatct 3284281 gtcagctgat cattgaattt aaaagctgac ataaacatga acacgatggc tacggcaaca 3284341 aacggccaga tggctttgac aaatttcatc tttatcactc cgattattta gattttagtt 3284401 tgtcactatg atcaatatca aacgtcagtt ttccgtcttc tactttccaa gcgaaattag 3284461 agtctttcgt cagttcgcga ataatggttt tctgtttaag gctgtctttt ttcacaggcg 3284521 caggtgtcgc ttcatggata tcgatcggtg tcacttcaaa gcgtcctgtt ccatttttct 3284581 tcaggtgata ctgaaccagt gcactgtctc ttgttctcgt ccagccttgg tcaaagacaa 3284641 agttgccgag gctgtagaaa atgacggttc cgttatatac ttcaatcggt tctaagacgt 3284701 gcgggtgatg gccgacgatg atgtcagctc ccgcatcaga catggctctt gcaagctggc 3284761 gctggcggtc atttggatca ttgtcatact cttgtcccca gtgtgactgc acaacaacaa 3284821 tgtccgcatg ttttttcgct tctgaaatca tagggatgaa gatttcagga tctgcgggca 3284881 gcacgcccgg cgtattcttt ttagccgcga aacctttccc ggacacatcg gtaaagccaa 3284941 gcgtcgcaat cgttaccccg ttgactttct ggtacgaaat tttctttttc gcatcactta 3285001 agctgtatcc cgctccaacg atatcaagat tttgcttcgc aaattctcca agcgtatctt 3285061 tcatgccctg aacgccgtaa tccattgcgt ggttgttggc gctgttgaga accgtgaaat 3285121 tcatatcctt caagactttc actgattcct tattcgtctg cagatgaatc tctttatctg 3285181 cttgtttata attcttttga taggttaccg ggttttcaaa gtttcctgct acataatccg 3285241 aggctctaaa gatcggttca acatattgaa aaatactgtc tgcccctttt tgctccgtta 3285301 ctttttcaac atagcgtccc atcataatat cgcctacaaa tgaggctgag agtacgtcgt 3285361 cagaatacgt tttgaccttc ggcgtttccg cttttcccgc ccacatgaaa gcgaacataa 3285421 ggacaaaaac gatcggaatg gcaataaata cgtgcttatt ggttttcttt ttttgctgtt 3285481 ttgtcagctt tagcagcttt tcatgaaagc tcagttcttt tttcatcgtt tgacacacct 3285541 tacattaaat taagtagtaa acaaacatga tagcaaaggt cgctccgctc aatagcagcg 3285601 tgcttccgaa cgtaatggtt aaaccttgtt tctgaatggt attggcaatt aaacctggca 3285661 cgatgatgcc gattcctcga aattctgcga tttcaaatgg tacaatcggg tatagaaaat 3285721 caaacgcgat ttttaggacg atccctgtta tcagcatggc agcgaatttt ctgcgtccgt 3285781 acaaaatcat aaatttggat aaaccgtatt tcacaatgac atacgtgagc aagctcacta 3285841 gcaaaacaag taaaataaag accggctgat taaacacaag tcctaaatat cccggtacaa 3285901 caagtcctgc cggcacgatc cctgtttttt ccgcaaaaat taaactgagt agtacaccta 3285961 aaattagtgc gatgtataaa tctgatccga acatgtctgc atttccccct agcttacgag 3286021 ctgctttacc ttgtattcgt ggattttttc aattaaaggc tctgcggcac catgaatatt 3286081 gccgacgcca tatatgacac ggttgtgcat tcttttcttt aacaattcca taatttcatc 3286141 tgttgactta tactctagat catgcagttt gtctgcagga attttgcctt cttcgtaggc 3286201 ttttacgatc ggttctgttg tttcaccgat taagatcagt tcacttgctt caatataagg 3286261 caatacgtca tttgcgaatt gctgtgtccg atcgacacgg tctgcgcggc agttcatgat 3286321 gatgatcgga tcatcggtcg ggtaaccgat ttcttttaca cgtttccata tattcaaagt 3286381 agaagaagcg tcgtttgcgg caaacccatt aacaaagtgc ccaggctcgc tcggactgat 3286441 cagcggaaga attctcattg ctcccggatc tggcggcgca ttcagcattc ccttaaatgc 3286501 tgtttcttcg tcaatgccga gtgcttgagc cacacccagc gccagagaag cgttatcagg 3286561 gaataccatg tattcaaatt tacgtaaata ctcatctgta atttttgagt tatcagcaat 3286621 gatgactttt gtgtttcgtt cttttgcttt ttgtttaaag aactcggtat attcactatc 3286681 tgtaatgaca agatggccat tataaggaat tgtagcagta aacgcttctg caatttcatc 3286741 aagcgtcggc cccatgacat ccatatggtc ttccaaaaca ttcacaatga cgccgatatt 3286801 ggcctgcaga agttcttcct gaaagatgat ttgataatct gggttaacag ccatgcattc 3286861 actgacaatc gcgttagccc ctctttctac tgtttctctc atgacttctt tttgctctcc 3286921 gatattcggc ccctgaggtt tccgtttaat cggcttttcc tccggtgtgt cccagtaaat 3286981 cattcttgca tctgttcctg ttgtttttcc aacagtcttg taaccggctt ctattaatat 3287041 tccggttgtc agccttgtca cagtcgattt tccgcggatg ccgttaatat tcacccgaac 3287101 agggagggca tcaatgtttt tctgatgtcg tcgtttttct aatattccga tgaccagtat 3287161 gacagcacag gctataatga gtaaccacat tgcttttcga catctccttc tatattgttg 3287221 taaattcatt catcagtata tagaatcact atgaattctc aatcggcatt atgtaacata 3287281 atcttcccta atcgactaag ccaaacttct cttttgaaag agattttata cctacaaact 3287341 gttttctatt tttggaaaac agcaggactt ataccttatc actttttaaa aaaatcaaag 3287401 agaatgcgct ttcatttttc tcctgatatc cttctggacg tatagtcaca ccctgctgtt 3287461 tgtatttaat atgcatttca aatcaatctt tttttcagcc tttgttatca agcatttcct 3287521 gctatcatgc gtgtttccgg ttcttatgaa cacaaaataa ttttatcctg tttcttaagg 3287581 acaaggtcat aatgtcatcc tttctgcatg gaataagcaa tatgaggccc attccaaaat 3287641 gactaaggag gttcgagatg aaaacgctaa acatacgagt ccgaattctc taacataatt 3287701 aaacattttc tgggatgata gtcttttctg tttctcccca tttacaggtc taaacgcatg 3287761 actttgaaac aattttaata aaacttaata tttgttcaag aaatcttcat ccatatttgt 3287821 gaagactttg tcaaaaaaag agtgaaaacc ttaaattttt caattatata tacaatttac 3287881 aattagattt cttttgatat ttttattgct aacttcggat tgttcatgat aatctatcta 3287941 tgtaaacggt tacataaaca aggaggagct gttttggcta caattaaaga tgtcgccgga 3288001 gcggcgggcg tttcagttgc gacggtttcc cgcaacctga atgataacgg ctatgtacac 3288061 gaagaaacgc gaacgcgtgt catagcggcg atggcgaagc tgaactatta cccgaatgaa 3288121 gtcgccagat ctctatataa aagagaatcc cgactgatcg gacttttgct cccggatatc 3288181 acaaaccctt tcttccccca gcttgcccgc ggtgcggagg atgaattgaa ccgggaaggc 3288241 tatcgcctta ttttcggcaa cagtgacgag gaattgaaaa aagaacttga ataccttcaa 3288301 acctttaagc aaaatcatgt cgcaggcatt attgccgcaa cgaattaccc ggatctcgag 3288361 gaatacagcg gcatgaatta tccagttgtt tttctggaca gaacgcttga aggggctcct 3288421 tctgtgtcca gtgacggcta tacaggagta aagttagccg cccaggctat cattcacgga 3288481 aaaagccagc gcattacgct cttgagagga cccgctcacc tgccgaccgc tcaagaccga 3288541 tttaacggcg ctttggaaat cttaaagcag gctgaagttg attttcaggt cattgagaca 3288601 gcttcatttt caattaaaga tgcacaatcg atggcgaagg agctgtttgc ctcttatcca 3288661 gcgacagatg gtgtgatcgc gagtaatgat attcaagccg ctgccgtttt acatgaagca 3288721 ttgcggcgcg gaaaaaacgt gccggaggac attcaaatta tcggctatga tgacattccg 3288781 caaagcggac ttctgttccc gccactttct acaattaaac agcccgcata tgatatgggg 3288841 aaagaagctg ccaaactgct tttgggtatc attaaaaaac agccgctggc agaaacggca 3288901 attcaaatgc ctgtcaccta tataggaaga aagacgacaa gaaaggaaga ttaagatgcg 3288961 taatatttgt gtgattggta gctgttctat ggatttagtg gtcacctcgg acaaacgccc 3289021 aaaagccggt gaaacggttc ttggcacgtc atttcagact gtgccgggcg gcaaaggagc 3289081 aaatcaggcc gttgccgcag ccagacttgg ggcgcaagtg tttatggtcg gcaaagttgg 3289141 agacgatcat tatggaacag ctattttgaa taatctcaaa gctaacggcg ttcgcactga 3289201 ttatatggaa ccggttacac atacggaaag cggaaccgct catattgtgc ttgctgaagg 3289261 cgacaacagc attgtcgttg tcaaaggcgc gaacgatgac atcaccccag cgtatgcgtt 3289321 aaacgcgctc gaacagattg aaaaggtcga tatggtgctg attcagcagg aaatcccaga 3289381 agaaacggtt gatgaggtgt gcaaatactg ccattctcac gatatcccga tcatactaaa 3289441 cccagcaccg gcccgcccgc tcaagcagga aacaattgat cacgctacct atctgacgcc 3289501 gaatgaacac gaggcttcga ttttattccc tgagcttacc atttccgaag ctctggcgct 3289561 ttatccggca aagctcttta ttacggaagg aaaacaaggc gtccgctatt cggctggcag 3289621 caaagaggtg ctcatcccgt ccttccctgt agaacccgtt gatacaaccg gagccggtga 3289681 tacgtttaac gcagcatttg ccgtggccct ggctgaggga aaagacattg aagccgcatt 3289741 gcggtttgcc aatcgtgccg cttccctttc tgtctgctcc ttcggtgccc aaggcggaat 3289801 gccgacaaga aatgaagtag aggagctgct gtcatgaaaa aacacggtat actgaacagc 3289861 catcttgcca agattttagc cgaccttggc cacactgata aaattgtcat cgcggatgcc 3289921 ggactgccgg ttcctgacgg cgttttgaaa attgatcttt cactgaagcc gggccttccg 3289981 gctttccaag atacagcggc agtactggct gaggaaatgg cggtcgaaaa agtcattgct 3290041 gcagctgaaa taaaagcatc caatcaggag aatgcgaaat ttctagaaaa tcttttctct 3290101 gaacaagaga ttgaatacct ttctcacgag gagtttaagc tgctgacaaa agatgcaaag 3290161 gcagtcataa gaacaggaga attcacacca tatgccaact gcatcctgca ggcaggtgta 3290221 cttttctaga aaggaagatg aaacatgcag attgaaatga aagacattca taaaacattc 3290281 ggaaaaaatc aggtgctgtc aggcgtttcc tttcagctca tgcctggcga ggttcacgca 3290341 ttaatgggag aaaacggcgc cggcaagtcc acgcttatga acattttgac aggcctgcac 3290401 aaagcagata aaggtcaaat cagcataaac ggaaacgaaa cgtatttttc caatccgaaa 3290461 gaagcggaac agcatggaat agcctttatc catcaggaat tgaatatctg gccggaaatg 3290521 accgttcttg agaatctatt tatcggtaaa gagatatcct ccaagctggg cgttttacaa 3290581 acaagaaaaa tgaaagcgct agcaaaagag caatttgaca aactttccgt ctctctttct 3290641 cttgatcaag aagccggcga atgttccgtc ggacagcagc aaatgatcga aattgcaaaa 3290701 gcgcttatga caaatgccga ggtaatcatt atggatgaac cgaccgcagc gttgactgaa 3290761 cgtgaaatca gcaagctctt tgaggtcatt acagcgttaa aaaagaacgg cgtctccatt 3290821 gtctatattt cgcatcgcat ggaagaaatt tttgcgattt gcgacagaat taccatcatg 3290881 cgtgacggaa aaacggtaga tacaacaaac atctcagaaa ctgattttga tgaagtcgtc 3290941 aaaaaaatgg tcggacggga gctgactgaa cgatatccaa aacgcactcc ttctctcggt 3291001 gacaaagtat tcgaggtgaa aaatgcttcc gtaaaaggga gttttgagga cgtcagcttt 3291061 tatgtgcgtt ccggtgagat cgtcggtgtt tcaggattaa tgggagccgg ccggacagaa 3291121 atgatgagag cgctgttcgg cgttgacagg ctggacacgg gtgagatatg gatcgctggg 3291181 aaaaaaacgg ctattaagaa cccgcaggaa gccgtgaaaa aaggtctcgg ctttattaca 3291241 gagaatcgca aggatgaagg gctcctgctc gacacctcga tccgcgaaaa tattgccctg 3291301 cccaatctgt ccagcttctc accaaagggt ctcattgatc ataagcggga ggctgaattt 3291361 gtcgatctgt taatcaagcg cctcactatc aaaacagcat caccggaaac gcacgcacgc 3291421 catttatcag gaggaaacca gcaaaaagtg gtgatagcca agtggatcgg catcggaccg 3291481 aaagtgctta tcttggatga gccaaccaga ggtgtggatg ttggcgccaa acgagagatt 3291541 tatacgctga tgaatgagct gaccgaacgc ggtgtcgcta tcatcatggt gtcatcagag 3291601 cttcctgaaa ttctgggaat gagcgatcgg attatcgttg tccatgaagg cagaatcagc 3291661 ggcgaaatcc atgcgcgaga agcaacacaa gaacgaatta tgacacttgc cacgggaggg 3291721 cggtaatatg aaaacggaac aactgcaaac agaacaaaaa cggattcact tcgacggagt 3291781 catgcaaaaa ctcggcccgt ttcttggttt atttattctc gttatcattg tatctatttt 3291841 aaatcccagc tttcttgaac cgctgaatat tttaaacctg cttcgccagg tcgccattaa 3291901 cggattaatc gcgttcggga tgacctttgt tattttgaca ggcggcattg atctttctgt 3291961 tggcgctatt cttgccctgt ccagtgcttt agttgcgggg atgattgtgt ccggtgtcga 3292021 tccggttctc gcgatcatcc ttggctgtat cattggtgcc gtactaggca tgatcaacgg 3292081 attattgatt actaaaggaa aaatggcgcc ctttatcgcc acgcttgcga ccatgactgt 3292141 gtttcgcgga ctgacgctag tgtatacaga tggaaatccg attaccggac ttggcacaaa 3292201 ctacggtttt cagatgttcg gacgcggtta ctttttaggc attcctgtac cggcaattac 3292261 gatggttctt gcctttgtca tcctttgggt gcttcttcat aaaacaccat tcggacgccg 3292321 aacgtacgct atcggcggca acgaaaaagc cgcgctcatt tcaggcatca aagtgacgcg 3292381 cgtgaaagtg atgatctatt ctttagccgg gcttttatcc gctcttgcag gtgccatatt 3292441 gacttcccgc ctgcattcgg cccagccgac tgcgggagaa tcgtacgaac ttgatgctat 3292501 cgcggcagtc gtcttaggag ggacaagtct ttccggcggc cgaggacgca ttgtcggcac 3292561 gttaatcggg gtgctgatca tcggcacact taataacgga cttaatctgc ttggcgtctc 3292621 atcattttat cagctggttg tcaaagggat tgttatctta attgcggtat tgttagaccg 3292681 caagaagtca gcttaggagg gttttacatg aaaaaggctg tatccgtcat tttaacgtta 3292741 tcattatttt tgttaaccgc ctgttcgctt gagcctcccc aatgggcaaa gccatcaaac 3292801 tcggggaaca aaaaggaatt caccattggc ttgtccgtct caacgcttaa taatcctttt 3292861 tttgtctcat taaaaaaggg tatcgaaaaa gaagctaaaa aacggggaat gaaagtcatc 3292921 attgttgatg cacaaaatga ttcatcgaaa cagacgagtg acgtggaaga tttaattcag 3292981 caaggtgttg atgcattatt aatcaacccg actgattctt cggcgatctc aacggcagta 3293041 gaatctgcaa acgcagtcgg tgtgcccgtc gtaacaatcg atcgatctgc ggaacaagga 3293101 aaagttgaaa ccctcgttgc ttccgataat gtaaaaggcg gtgaaatggc cgcggcgttt 3293161 attgccgaca aacttggaaa aggagcaaag gtggcagagc ttgaaggcgt ccccggcgca 3293221 tctgccacac gggaacgcgg ctcaggattc cataacatcg cagaccaaaa gctccaagtt 3293281 gtcacaaaac aatcagctga ctttgaccgc acgaaaggcc tgactgtcat ggaaaacctg 3293341 ctgcagggac atcctgatat ccaagctgtt tttgctcaca acgatgaaat ggcgctcggt 3293401 gctctcgagg caattaacag ctcggggaaa gacatattgg tgatcggttt tgacggcaat 3293461 aaagatgcgc tcgcttccat taaagacaga aagctgtcag ccaccgtcgc tcagcagcct 3293521 gaattaatcg gtaaattggc tacagaagca gcagatgata ttttgcacgg gaaaaaagtg 3293581 caaaaaacaa tatccgcgcc tctcaaacta gaaacacaaa aataattgtc tgatgtttag 3293641 gaacctgcga taacgtgaat agagatatag aatgaattat ttctcttacg tgaggagagg 3293701 aacggcatga acaaaccaac aaaactattt tcaacattag cacttgcggc tggaatgact 3293761 gcggcggctg ctggcggcgc tggcacgatc catgctcaac agccagaaac aacggtaagc 3293821 attgatgatt tatacagtta tccgattgat tcttatttgg tatcagcaga ggctctaaat 3293881 gtcagaacga agccttccgc atcaagccag aaagccgata cgctgcactt aggagatagc 3293941 ctaaagctga tttccttctc aaatgctgac tgggcaaagg ttaagtataa aaatggaaaa 3294001 acaggatttg tatccactca ttacattgtt aaagcagcga caacggtaaa aaccaaaaca 3294061 aaaacaaaag tgtatacatc cgctgacgga aagagcatta agactcttcc agcagacaca 3294121 agcgtttctt ttttaggctg gagtaaaacg aataaaggcg gttttgattt tgattgggta 3294181 ttcgttgatt acggcggtac gacaggttat atgaaaacaa aggatttaca catgacaaaa 3294241 taactgagag ggattccgca taaatgcgga atccctttta ttatgaattg atttgtcaca 3294301 ttcccaagat atttctcagg aaatattgtc gtatgctgtg tcgaaacctt acatgatcat 3294361 cgacattttt gttcacgcta aaaagcggag gtgtaaatat ggatcaattt gaagcagcat 3294421 atgaatcgta taaagcccgg caaacaactg ccgatcaaga aaatgttcca tctggaaaag 3294481 aagaaattat tgcggttaga agaaatgagg aagacaatat tatcgcagtg aaaaccaata 3294541 caggaagaga gctcgactac cctactgcgc tgtcagaagc aaaatcagga aaactcgctc 3294601 atgttgatgt cttccataaa tacgggcgtg acattttgcg aagtgaaccg gacggcatca 3294661 aggaaaataa cctgtctgag ctgccggatt tttaaacaaa tacagccctg ccgtatgttg 3294721 gacagggctg tattttaaac aaaaggctgc tggatgtatt cggctaaccg ttttgcactg 3294781 tgagaaatat cctctgcagc tgcataattc acgccataga acacatatgg aggcagatac 3294841 ttcatgccga tcagattact cgtggcctga aatggtttca atagctcact gatcgagtaa 3294901 tgatttgctc cgcccgcttg atatttttcc gcttcgctcc ctgttgatac agccagcatc 3294961 agctccttgc catgcaaggc atttccttct gaaccaaaag cccagccata agtcagcaca 3295021 agatcctgcc attttttcaa gagcggcgga gagctgtacc aatatagcgg gaattgaaag 3295081 acaatccgat cgtattcctc gcacagctgc tgttccttcg caacatctat cgcttcatcc 3295141 gggtattcct tataaagatc ccgtactgtg atattgtcat gtttactcaa ttcctcagcc 3295201 cacgccttat taacaactga ggtctccata tgaggatgca ctgccaaaac caatattttc 3295261 atcagaccac acctttactg ttttgatgtt attttatcta aaatcaggaa aagagccaaa 3295321 taaaaagaaa gccctgctaa aaggggcttt ctttttttct tttattcagg gcttccttca 3295381 gttgtttcga tatctttcgc aaaatcaggg ttatccagat tcgcattaaa gaaatccgct 3295441 gtgttcggaa gtctgagatt catgttcatt ttttgagaaa tcgtaaccgt gcaatcctca 3295501 agcacatagt caaaaacgtg tccgcctgaa ttgcgtcctt cgtcaatgaa gtgcaggtga 3295561 tagccagaaa cggcgattcc gtttgcataa gctggtgtca agaaacctac aatcgttcct 3295621 ctcacgttgt cgaagttgaa aatcggctgt gttttgaccg cttcaaccat tggcacgtaa 3295681 ggtttttctt gaagttctac tgttcttgtc tgcacctttt taaacaatcc gtcaatgcga 3295741 attgcataaa ataagtttct gcttggcagc atgctgttga tctctttttc aaagtcttcg 3295801 cgtgtcattt tcgcatcaat tttgtgcgtc atgtccggtg taaagaacgt aaatgaacag 3295861 aacggtgaac ggtctccatt ttggaccggt gtcgcggttc cgtctgagcg aagacggtaa 3295921 aattcgccgt caaacccaat cagctctccg tcaagcttgt taaaggttcc gataccgaag 3295981 tctccatatt tcggaatctc tgacagttca aaatctccgt catatactcc gtctaataga 3296041 gaagtcattg ttgatacttg ataaatctgg ctcacaggct gatctttttg accacggctg 3296101 agcacttgaa tgttgctttc tcgtttcata tttcccttca ctccttttat ttagtgctgt 3296161 tcataaaaca gtgtcgtgat gcgcagagtg ctagagagct ttcgttttca tgagttcccc 3296221 gaattctttc ggaagcttgt cacttgctaa attaatgtta tcactgtagt caaccgggac 3296281 atcgatgatg acaggacctt cagcgttcat gccttgacgc agaacatctg ccagctggtc 3296341 tggtgattct acgcgcaagc cagttgctcc gaagctttcc gcatatttca cgatatcgat 3296401 atttccgaaa tcgaccgcag atgtacggtt atattttttc aattgctgga atgcaaccat 3296461 gtcatatgtg ctgtcgttcc atacaatgtg tacaattggt gcttttagtc gaactgctgt 3296521 ctctaattcc attgctgaga ataagaaacc gccgtcacca gagacagaaa ccactttttc 3296581 tcccggtttc accaatgaag cgccgattgc ccaaggaagc gcaacgccga gtgtttgcat 3296641 accgttactg atcattaatg ttaacggctc gtagctgcgg aaataacgtg acatccaaat 3296701 ggcgtgcgaa ccgatatcgc aagttactgt aacatgatca tcgactgcat tacgcaactc 3296761 tttaacgatt tcaagagggt gcgctctgtc tgatttccaa tctgcaggca cctgctcacc 3296821 ttcatgcata tattgtttta aatcagaaag gattttctgc tcacgctctg caaattccac 3296881 tttcacagca tcgtgttcga tatgattgat cgtggacgga atgtcaccga tcaattcaag 3296941 atcaggctgg taagcatgat caatgtcagc gataatctcg tctaaatgga taattgtccg 3297001 gtctccattg atattccaga atttcggatc atattcaatc gggtcatagc cgatcgtcag 3297061 aacaacatct gcctgctcta gcagtaaatc gccaggctgg ttgcggaaca aaccgatacg 3297121 gccaaaatat tgatcctcta aatctctaga aagggtaccg gcagcttgat atgtttcaac 3297181 aaatggaagc tgaacctttt tcaaaagctt gcgaaccgct ttaattgctt ccggtcttcc 3297241 gcctttcatg ccgaccaaaa cgacaggaag ttttgctgtt tggatttttg ctatggccgc 3297301 actgattgca tcatctgctg caggaccgag ttttggcgct gcaacagcac gcacgttttt 3297361 cgtatttgtg acttcattca caacatcttg cggaaagctc acaaaagcgg ccccagcctg 3297421 ccctgctgac gctatcctaa atgcatttgt aacagcttcc ggtatatttt ttacatcttg 3297481 aacttctaca ctgtattttg taatcggctg gaatagcgcc gcattatcca aagattgatg 3297541 tgtccgtttt aaacgatctg cacggatcac gtttccagca agcgcaacga cagggtctcc 3297601 ttcagtgttc gctgtcagca ggcctgttgc caagttagag gcacccggtc ctgatgtgac 3297661 taacacgact cccggttttc cagttaaacg gccgactgct tgggccatga atgctgcgtt 3297721 ttgttcgtgc cgggcaacga taatttcagg tcctttatct tgtaaagcgt caaataccgc 3297781 atcaattttt gcacctggaa tgccaaatac atgtgtgaca ccttgctcca ctaagcaatc 3297841 aacaacaagc tccgcccctc tgtttttcac aagggatttt tgttcttttg ttgcttttgt 3297901 caacaccctc actccttatt atgcatttta aacgtaaaat tttaaatatc ttgtgataag 3297961 tttcactata cactctttgg aaattgacct ccaatatcga ttcgccttat gattaatatg 3298021 taatacgaat tattaaccta tggaaaggaa tgcatattga atggagcttc gccatcttca 3298081 atactttatc gcagtagccg aagagcttca tttcggaaag gctgcccggc ggctgaacat 3298141 gacgcagcct cctctcagcc agcagatcaa acagctggag gaagaagtcg gagttacgct 3298201 tctgaaaagg acaaaacgat ttgtcgagct taccgcagca ggagaaatct ttttaaatca 3298261 ttgccgcatg gcattgatgc aaatcggaca aggaattgaa ctggcacagc ggacggcccg 3298321 cggcgagcaa ggccttctcg taatcggttt tgtcggatca gctacatatg aatttctgcc 3298381 gccgattgtc cgggaatatc gtaaaaaatt cccatctgtg aaaatagaac tgcgtgaaat 3298441 atcctcgtct aggcagcagg aggagctact aaagggcaac attgatattg gtatacttca 3298501 tcctccctta cagcatacag ctttacatat cgaaaccgcc caaagcagcc cttgtgtttt 3298561 agctttgcct aagcaacacc cattgacttc taaggaatca attacgattg aggatttaag 3298621 agatgaacca attattactg ttgctaaaga agcatggcct actctataca tggattttat 3298681 tcagttctgt gaacaagcgg gcttcagacc caacattgtc caggaagcca cagaatatca 3298741 aatggtgatt ggtttagtca gtgccggaat tggtatgaca tttgttcctt cctcggccaa 3298801 aaaattattt aatttggatg ttacttatcg aaaaatggac caaatacagc ttaatgcaga 3298861 atgggttatc gcttaccgca aagacaatca taatccgctt ataaagcatt ttattcatat 3298921 ttcaaattgt cagcagacaa gaactaaaga gagtgatgca ggtacatgaa caatacttgc 3298981 aatctctttt ttcttttggg attcttatgg aatttttatt aatttaatat aatcgcttag 3299041 tacaacttta tatcagtata cgtatacata cagtacaaat agttggcaag gacatcagta 3299101 agcgcaggac attagtttga ttttaaaaat gaaagataga gaggtgaagt aaattattga 3299161 gttcaccggc atattcacat tgctcgcttt tttcgtaaca atgattttta ttttctggag 3299221 accaaaagga ctaaatgaag ctatccccgc cacatttggc gctttaatgg ttttattgtg 3299281 cggaagtgtg tcattggcag acttagggga aatcggaaca aaagtcacgg gtgcatcggt 3299341 tacaatcctt gccactatga ttatggccat tgcactagaa agctttggtt tcttttattg 3299401 ggtggctgca aaactgctcc aacaatccaa gggttcaggc atcaagcttt tttggctaac 3299461 caatttgctc tgctttctca tgaccatttt ccttaataat gatgggagca ttttgatcac 3299521 aactccaatc cttttgcttg tactaaaata tttaggttta aaaaaacatc aaaaagcccc 3299581 atatttatta agcggtgttt taatagccac agcctctagc gcaccgattg gcgtaagtaa 3299641 tattgttaat ttaatttctc tcaaaatcat tggaatggat ctatatcttc acaccgccat 3299701 gatgtttgtc cctagtatga tgggactcat ttttatgact tgtctactgt ttatgttctt 3299761 ttataaacgt cttcccaaaa gcctgccaga tataccgggc cattttcagt ctctgcggca 3299821 tagaaggtac catcctcttc attcgccatc agctccttta ccagaacgaa atcaaacaaa 3299881 aatcatgttg tttgtgcttg catttgtttt tctcgtcaga atgagtctat ttgcagcatc 3299941 atataccggt atttctgttc ctctagtcgc tgtcatcgga tcttttatcc tgttgagctg 3300001 gagatggatt tatttcaaaa cctccccaag agacttgtta tataaatcgc cttggcacat 3300061 ttttatattc gcttttacta tgtatgtctt aatttatggt ctgcataata ttggattcac 3300121 agagttactt gtgagttatt ttgaacctgt ggtttctgga agcctcgccc atgcaacttt 3300181 cgcatcaggt atctctactt cagttttttc taatctcttt aacaaccatc cagcgttaat 3300241 gatcagtact tttaccttaa ctgaaatgac cctgaatcct tcaacaacaa aaatcatcta 3300301 cttggcaaat attatcggca gtgatatcgg ttcattatta ttacctatgg gaaccttagc 3300361 aacgcttatt tggatgcata tattaaaaca gcatgatgaa agtatttcat ggggcgaata 3300421 tataaaaacg accattatca tcattccgct gactgttctt tttacgttaa catgtttata 3300481 tttttggatc agttggttat ttctttagca cagtatgaaa cgaaaaactg ccttctgctt 3300541 ttcaagaggg cagttttgta tacactaggg aagatgcatt gtctttagat gatttaactt 3300601 ccaaatgact ggctctccac ttgcgttaat aagctcaatg atattattag agacaccctt 3300661 taatagtccg actttttctg gcacctctcc catatcaaat atgaccaatt caccaatatt 3300721 ttttttgatc tgctcctcaa aattacgcac aagaggaact ttggaaggca cgaccggcaa 3300781 ttgtgagttg tcaagagtat acggtgtttg ttcagttgaa taaggggtaa accattttaa 3300841 atgatgcata gatataaaaa gtattttaaa tacgggtgag aaaaatacaa tataatcgtt 3300901 taaaacattt gtaacatatc catggatcga tcgaccccca gttacataaa cttcaataaa 3300961 ctggcctttg accttgttta atgtatttct atatgaaaaa gcttgagttt ctgcctctat 3301021 cattggatct tccggattga tcaaaaatgg cttctcagta ctggtcacta ttttcgcctt 3301081 gtttatttga tgaagatgca acaagggaat ataaagataa ttgcagccat caaaaataac 3301141 aaaaatatcc tgtccgatat ctatgagggt gccgacaaac cttgtatctc ctgaaatgac 3301201 aacctcaaca tctgtgttaa ggaattgatt caaacctttc acgattctcc tcctttaact 3301261 gaaaaagggc atcactttat ctgatgctcc tccattatct attaaaattt acgtttccag 3301321 tgatagtcta tcgttctgac aatcgtttca tagctataat cttccttttg ttttcctgaa 3301381 ctttttattg aacttgaata gcctggtgat cttgatgatt gataatctga agatcttggt 3301441 gatcgtttag atgattttga tgattgataa tctgaagatt ttaatgatcg tttagatgat 3301501 tttgaagaac tttttgaacg tgacgaacgg ccagatttgg atgattgata atccgaagat 3301561 tttagtgatc gtttagatga ttttgaagaa ctttttgaac gtgacgaacg accagatttg 3301621 gatgattgat catctgaaga ttttagtgat cgtttagatg attttgatga gctatatgat 3301681 tttgaagaaa tgaacgaatt gctgtcctta tcattattgt cttcctggtt ttgttcattt 3301741 ttttgatcct cttttttgta cgaccctttt ggacctaagc tgatgctttt tatgtgaaaa 3301801 ggatagatgc gaagcacctc ttgatttttc actatagtat aatggccgtc ggcattatct 3301861 acaaggatac cctcaatggc ttccggacct ccacgattaa ttgaaaccca tttatgagtc 3301921 agactcttaa aaacctcgct taaatcatca gcttccaaaa ctccaactgg cgtctgctct 3301981 tctattttca aatcaggctc gtgtttactt atacttttga tgtgatggat attaaaatac 3302041 actaccccat cctcatttgt gtttaacgca gcgtaatcat ctcccagcca gaccaatctt 3302101 ccttttttag attccggacc cccttggtta aattgaactg attggtttat taaatgtccg 3302161 attaagctat gaaaatcatc agcatcgagc atttcctcag tctcaattgt tgtggtgcta 3302221 ttattggtat cctcagtaat acttttcaca tgctccaact gataataaat tatttttttt 3302281 tcagcttgta aagctatata atctgatttt acagctgtta attttccttt tttagattcc 3302341 ggacctccac gatatacagt aacaatttta tctttcattg agtgcaaaaa gttataatac 3302401 gatatttcat tatttgaatg atatttcatt ctcctcttgc tcattcaaat tcctcctagt 3302461 cacttataca tagatgataa acatactgca tatatacgtg tcacatttat ttgttgaact 3302521 aattcaatag cctaattgtc gctttttccg cgaataccca ttttcacgca ttcataaaat 3302581 acttaaatga tctttgaggt attgtgaacg gtttttaata tactcgcaga tcacatccgg 3302641 ctcacggtca aaacgctcaa tatcattctt tttatacggg tccatgagga caaacggcct 3302701 aatccgttca tacatcgcca tgattttcgg ttccatatat tctattgtaa aaagagattg 3302761 gagcgttttt tctaacaggc gcttgtagga cttgcgaaac tcggattcat ccaatatccg 3302821 ggcggttagt gtattaaatc cttgaattct tacataatcg gcagccatcc gctctccatg 3302881 gatatccctg ccccaagtcg catcataatc ccaaggaatc acctcaaata atccggtttc 3302941 cccgcttctg tataatgcgt agttgtggac aaacccgtca tagttcgagg tgaatacaat 3303001 accagcaagc cagcgcaaat acttatcgac atccacgtgt tttgtcactt ctgacttaaa 3303061 ctgagcttta gggaccgtat taattttaaa aatcatatct tgtaaataaa aatcatcttc 3303121 ctcagtccct gttttctttt catatccaag ctccagcgat gttttcgttt ccctttctaa 3303181 atcgctcatc agagaaaagt tggcatcatc atccaccgca taaaaaatcg cgccatcagc 3303241 cagcttcctt ttcgccaaat aatattcatc tacggattca agttcaagat aaaccccttc 3303301 attcttccca ttcatcttta caaacgcaaa ctctgccttt ggagacagtg tccctagctc 3303361 cgagaaaaaa tccagagaca atttgtttct catcaaggaa gggtctttat actccgcatt 3303421 taagtgaatc tctcgcgcgc cgcggaatgt tttcggctga taaaaggaaa tatggtatga 3303481 cttctttttg aagtctctga tatgtgatcc ccgataagcg atatcaatat ccagcctttt 3303541 ttgatttacc ttcatcacag ctggcaccgg atcatcgtcc catatatcct tttttaattc 3303601 acgcaagtct tttggatgaa caaacagctg ataaagcggt aaattggatt gattcttcat 3303661 ccataatcct ccttacaaat tttaggcttt tatttttata agatctcagc ggaacactta 3303721 tacacttttt aaaaccgcgc gtactatgag ggtagtaagg atcttcatcc ttaacatatt 3303781 tttaaaagga ggatttcaaa ttgggccact attcccattc tgacatcgaa gaagcggtga 3303841 aatccgcaaa aaaagaaggt ttaaaggatt atttatacca agagcctcat ggaaaaaaac 3303901 gcagtcataa aaagtcgcac cgcactcaca aaaaatctcg cagccataaa aaatcatact 3303961 gctctcacaa aaaatctcgc agtcacaaaa aatcattctg ttctcacaaa aaatctcgca 3304021 gccacaaaaa atcatactgc tctcacaaga aatctcgcag ccacaaaaaa tcgtaccgtt 3304081 ctcacaaaaa atctcgcagc tataaaaaat cttaccgttc ttacaaaaaa tctcgtagct 3304141 ataaaaaatc ttgccgttct tacaaaaaat ctcgcagcta caaaaagtct tactgttctc 3304201 acaagaaaaa atctcgcagc tataagaagt catgccgcac acacaaaaaa tcttatcgtt 3304261 cccataagaa atactacaaa aaaccgcacc accactgcga cgactacaaa agacacgatg 3304321 attatgacag caaaaaagaa tactggaaag acggcaattg ctgggtagtc aaaaagaaat 3304381 acaaataatc taagttttca ttgtttcaat aggctgccgg cggaggtacg gaagcctatt 3304441 tttttatttg ccctgtatta gatatatgtc atgacataac atatgcaacc cgcatcattt 3304501 ggtttccttt aaaccatttc gttataatca aggtatccta acgataaagg cggttgttgc 3304561 tatgtacata tttcaagctg atcagcttag tgccaaagac acatacaagc tattgtcagg 3304621 taccgttatt ccccgcccca ttgcatttgt gacaacactt tcttcaggag gagcggtaaa 3304681 tgccgcgcct ttcagttttt ataacgtcgt cagctcagat cctccgcttc tcagtatttc 3304741 tgttaacagg acggaaggac gccaaaaaga tacagcacga aacgcagtgg agaacggaga 3304801 atttgtcgtt catgtcagtg atgaagccat cattgaagat atcaatgaaa cagctgcaag 3304861 cttaaggccg gatgaaagcg agcttacacg cacctcgctt catcctgttg aaagcaaagc 3304921 tgtttcagtt cccggcatta aggaagcccg cgttcgcttt gagtgcaaat tagagcggca 3304981 tattaccttt gacaatgatc aaggcatcac tacagcagat ctgctcatcg gaagagttgt 3305041 ctgcttccac ctagatgaaa aggtgtatga tgcagaaaag ggatatattt taacggatga 3305101 attaaagcct gcctcacgat tggcgggaaa tcactatgcc aagctggggg aagaattcac 3305161 actgattcgt cccagctgaa gagaaggact atttaaatag aagaaactag tcaaaaagac 3305221 cttatgatta caaaatatcg cctgtaaata actgaaaaaa tatcaaaaaa aagaacaccc 3305281 agagcaagct cggggtgttc ttttatgaaa cgtttttcct ttttcttcgt ataaaggtag 3305341 attaggagga attggaatga caaacttttg gattttaatg ctgatcgcta ttaccatcag 3305401 tctcgcctct caatttttta taaagaaaaa atacggtatt gataaatccg gctggcgata 3305461 taagcatgtc agcaatacac acaaatggat cgaaatcact ttacttattt tgtttgtgtt 3305521 ttcactctcc ttttttccag ttgaatattt gcttctttta ttttttattg tgattgactc 3305581 aatacgtatt tttatggagt ggcattatag acctgaagat aaacagtata tgtaccacat 3305641 tgtagaggtc tcccttatgt ttatgctttt gatttatgtt tgtaccctat agttatttaa 3305701 atccccacag ccgctccgtc tccccgagga tcggctccgc cttggagaaa gccttcttca 3305761 tcaactttga ttgcagccgc ttgtcccatc agcggatcat agtcaccgac aacctccacg 3305821 agatgcccgc tgtctttcag tttttggatt gttttgtctg tgaatctgcc ctcgactctg 3305881 agaccttcgt attcctctcc ccacgttctg ccccataccc agcgcggttc gctgattgcc 3305941 tgctgtggat gcattccgta gtccagcatt cgggtaatga tggccgtctg ggtctgcggc 3306001 tggccttcgc cgccttgtgt gccgtacaga atttttggct ttccgccttt acagaccata 3306061 gccggcatca acgtatggaa ggtgcgcttt ctcggttcaa gcgtgttgac atgattttca 3306121 tccagtgaga aaaacgatcc gcggttttgc agtaatatgc ctgtatcacc ggcagtgact 3306181 gccgagccaa attcaaagta caggctttga atgaatgaca ctgcgttgcc atccgcatcg 3306241 attacggccg catatgccgt atcacttccc accggcctgc tttctgccgg tattgcgaga 3306301 tagccgattt cttctgccaa ttgttttgca taacgtttgt ccaaaagcct ttcaagcgga 3306361 atgtctgcaa acgccggatc agtcaggacg gcatcccgat ctagaaaact ctttttcaat 3306421 gcctccacaa gcacgtgata atactcaaat gaaccgtgtt cgatttgggt gaaatcatag 3306481 ttttccaaaa tgttcagtgt taataaaccg gtaaatccct gagaattcgg cggcgcctga 3306541 tacacactgt atcctcgata atcacttgat acaggcgctg cccactcacc ccgatgcgct 3306601 ttaaaatcat cgattgtcat gtaactgccg ttattctgta aatgtgagac aatccgctga 3306661 gcgagatctc cttcataaaa tgcgcttctt cctttttcag caatcaagtt cagactgtct 3306721 gcaagctctt tttgcacaaa ccgctctccc gggacaggtg ctttgcccct tctcgtgaag 3306781 atgtcagccg tgtaaggcgt ggaagccagc agttcaatat tcttttctgt gtgacgacac 3306841 tgatcagctg atacaggaaa cccattttgg gcataatcgc gtgcgggctc caatacatct 3306901 gcaagagaca gacgcccgta ctccttcagg accgcatccc agctatcaac cattcccggc 3306961 acggtaatag cactgtcaat tccccgcagc ggaatcgcgc tttttccctt atatacatct 3307021 ctcgttacgt tttttcctga acggccgctg ccattgtaga cttttactgc ctttgtttcc 3307081 tggtgaaagg tcagccaaaa ggaatccccg ccaagtccgg tcatatgcgg gtacacaacc 3307141 gcaagacaag cactcaccgc aacagcggcg tcaaacgcgt tgcctccctt atccagtatg 3307201 cggtttccgg cttgagaagc gagataatgc ggactgacga ccatttgctt tgtaccgatg 3307261 acagatttgt tcatcacaag tccccttttt taagaaattt tcttcagtat agggagcctg 3307321 atttttcaca tctactgatc cggcagaaaa actgacgaac tttcttcttt tcgcaaataa 3307381 taagatattt tcgcattcat ttcgaaaaca aatgaaaaat tattatttct atacgtaact 3307441 tttatgataa aatgattgct aaaaggctac gaaagcaggt ggagcaattg agtcatgaat 3307501 atcaaatccc caaccttgta cttgatgaga ctgataaaca aattctcacg attttgcatg 3307561 aagaaggcag aatttcttat acggatcttg gcaaaagagt cgatttgtca cgggtcgccg 3307621 ttcaggcccg tatcaaccaa ttaattgaag ccggtgttat tgaaaaattc accgctgtca 3307681 tcaatcccgc taaaatcggc atccatgttt ccgtgttttt caatgtcgag gtagaaccgc 3307741 aatttttaga agaggtcgct cttaagcttg aggaagagcc tgcggtcacc agcctttatc 3307801 acatgacagg cccgagcaag ctgcatatgc atgggatctt taccaacgat caagaaatgg 3307861 aagaattctt aacaaaacgg ctgtatccat tgcgaggcgt cgtcagtgtt gattgccaga 3307921 tgctgatcaa acgatacaaa agccgtatgg gaatgaagct gtaaaggaga gaaacaaatg 3307981 aaaaaccatc cttatcggga tatgacggcc gcaatggttc gcaccggcat attagggttc 3308041 ggcggcggac cttccgtgat tccgctgatc cgccatgaag cggtcaataa atataaatgg 3308101 attgacgatg atgaattcgg agaaatatta gcaatcgcta atgcgcttcc cggaccgatt 3308161 gccaccaaaa tggctgctta tctgggcttt aagctaaaag gcacattagg tgcaattgtg 3308221 gcgatcctcg cccacattct gcctacatgt cttgcgatgg tgggcttgtt tgcggctgta 3308281 aatgtgttaa gccattcagc aattgttgca ggtatgattg gtgccgtcac gccggtaatt 3308341 gcggtcatgc tcggaatcat ggcgtacgag tttggccaaa aagcgcttaa aggtttcggc 3308401 tgggttaccg gcatcctgtt ttttatcatc gcttttatcg gcctgcaaac tttacagatt 3308461 aatcccggcc tggtcattat cattttctta gcttacgggg cgtttcattt taaactgaaa 3308521 gacaaaatca caaataaaca ttcaaaagat aaaggaatgt cagcctcatg atatcgatct 3308581 atttatttat ggcgtttttt atcgcaaacc tactgggata tggcggcgga cctgcgtcta 3308641 tcccgctaat gtttgaagaa gtcgtaaaca gatacagctg gctctcaaac gatcaattct 3308701 caaatatgct cgcacttgcg aacgcattgc cgggcccgat cgccacgaaa atcgctgcgt 3308761 atgtcggcta cagcgcaggc gggtggcccg gcttcctaat tgccctgatc gcaaccgtcg 3308821 taccgtcggc gctcgcattg atcgtcctgc tgcgcatcat ccagcgcttc cgccaatcac 3308881 ctgtcatcaa aggcatgacg ctgtccgtcc agcctgtcat cgcggtcatg atgctcattc 3308941 ttacctggca aatcggcgca gacggcatca aagcgatcgg ctgggtccaa tcgatcgtga 3309001 ttacgggaat ttcgctcctt gccatgacaa aattcaaaat gcatccggca tttttgatta 3309061 ttgcggcgtt tttatatggg ggccttgtga tcccttattt atagaaaaaa gcacctggac 3309121 aggtgctttt ttattttagc ccagaaatgc cgtttgatat gacagctgtt tcttctcctg 3309181 cgtcactctt gatcatgtgc ttgacttgca gcgtggttcc tgccattctc acagattgct 3309241 tcaactggga cgaattggtt tcaacttgta tccaaacagg aggctggacc ttccaaaata 3309301 aatagagtgc aagaatcagc aagccagcaa tgaccgacag caaaaacttc atatcgcatc 3309361 gcttcttttc agtaagcggc tcgcagcgga cagcgcctga tgatcacgaa gaatatcgcc 3309421 tggacgattg ccttctccca gcacatagcc tttaaaggac attcccataa aatgaaaaat 3309481 atgttcgaat tgctgaatca gcggcagccc ttttattttt ggattgtctc cgcccactgc 3309541 tattacatat gcctgtttca ctgacatttg ctgtttaaaa tcaggaaatc tcggatctct 3309601 caacgtctgt gaccagcgat caataaacag ctttaatgtc cctgacatgc caaaccaata 3309661 aattggggtg gcgaatataa gaatatggca ctgcaatatc cgttcaatga tagaatcgta 3309721 gtcatcttga acaggacgaa agccgccttg ggcgtgacgc agatcttcaa ttggttgaat 3309781 tggatatttc tgcaaataaa tgtgctccgc atcgaatcct tgaacagcct tctccgcaag 3309841 aacatccgta tttccgccag accgagttcc gccgttaata accgcaattt tcatgatgca 3309901 tctgctcctt tgtttacgaa tgattttctt catcatataa tggattcatc aatcaataca 3309961 gatgattatt tcgattaatc caatcgctaa aaccgattta gaaaggaaga gaacaagtgg 3310021 aattgaagca gctgatcacc tttattacgg cggctgaaca tgtaaacttc accctaaccg 3310081 ccaaaatgct taattatgca caatcaagcg ttacctctca gatcaaatca cttgaagaag 3310141 aaatcggaac gcctttattt gaacggctcg gcaagcggct tatcttgaca gaagcaggaa 3310201 aaacgttcaa atcttatgca cagaagatca ttgcgttaac agaagaagcg aaaatggcca 3310261 caaatcaagt aagagaaaca accggaacct taaaaatcgg ggcgacggaa agccagtgca 3310321 cataccgcct gccccctatc ataaaagaat ttaaacaggc ttttccccaa gtaaagctca 3310381 tattcaaacc atatatctcc aatgaacaag cgaaagaaca gctcttacag ggccagcttg 3310441 atatcacctt catcttggat gtaaaccgga tggaagacgc actgcacgtt gaatctttga 3310501 ttcaggatga gatcaaaatg gtggctgcta atgaccatcc ttttcctgcg gatttaccag 3310561 taacattgaa ggatcttcaa aacgaaactc ttctgctgac agaggacggc tgctcgtacc 3310621 gcacgctctt tgagaacaat ttgcatgact ccggtatcta tcctaacaaa ttggaattcg 3310681 tcagcataga agccatcaaa caatgcgtga tggccggact tgggattgga atcttgcctg 3310741 aaatgacagt aaaagatgat attgcagcag gccggatgaa agaactcaat tggcagagcg 3310801 attgccccgt tttcactcaa ttagcatggc ataaggacaa gtggatgtct gcgccattaa 3310861 aggcttttat cgatttgaca cggaaaacat tcaaataaaa cctctccaca aggacgacaa 3310921 ggtttttgag accagggcac acacatacaa aaaaaacact tgatgactta gagccccaag 3310981 tgttacacgt gatttttctg ataaaacgtt cgcaaaacat gcgtctcaag gtcagccagg 3311041 cggacaggga tcggcagcct gctttcttga ttgatcaagc tcatcgtgat ctgatagctg 3311101 ctgtctaaat caatataatt accgcaagac aagaaaatag gcttcacgtc ccgccgcgtt 3311161 cgcagcgccc gtccatatac ctcgccgtca atgataatat cggtgtatgc gcctacttca 3311221 atttcaggcg tcacgaaatc gcagcctttg attttgagat aggttttcgc tatcccaatc 3311281 gtcggcttgc ccagaaaaaa agccgcatgg gtggcaacgc ccatatgatt gtaatgcaga 3311341 tatccgttgc catcaaacaa gaagacatcc ggctccgtct ccagcttttt cgccgcctcg 3311401 atgatcaagg gcagctcgcg aaacgcaaga aaaccggaaa catacggcac gctgattctc 3311461 cccatgctgt gcactttttc aatgacttct tttgtatcag cgtcaattac gataatacag 3311521 cacactccgt atggttctcc atcctgctcc caataggcca ggtcgacgcc tgcgcaggtg 3311581 ttgatggagt ctggatggat cgtgggggat aggttgatac gatttttaag gttaaattgc 3311641 acttgtaaaa agtcttgttc ctttttcata tcaaatttat gcacatcaaa taccttcata 3311701 acgattgctc actctcgacc taaattaatg tgagtctctc ttctcgattc tagtatttca 3311761 aaatgaggac tatctgtatc tatctcgtac ttatttaata gattgccttc ttcatcccaa 3311821 ttcttttcag aaattagtat ggaatgctca tactgttgct cacttttttt cctgccattt 3311881 tcaaaccaaa ttatgcttat accgtgcaat tgcccatatc ggtattcttt ttcacttttt 3311941 ttattcccgt tttcataaaa ttcacatgtt aaaccatggg ccagaccatt cttatattta 3312001 gtaaaataga tgatttgacc atttggatat aattcgtaag ccagccctgt aaacggctgg 3312061 ccattttcgt cttcaggatt atctaaaatc tcatcactta ccgaagagaa ccataaatcc 3312121 tcaaagtcca ctcccttttc ttttatactc ttcatatcat attcattttc catactttaa 3312181 agcctccggt atataatttg tattttgagt tatatattca caatgtggac atctaggcat 3312241 tgggacacct tctggcatct ttttatttat tttcctagca cttactacat ataccattaa 3312301 atcttttaaa tccgcatcag gtctttgaag taacgcttca tttagagcat taacttcggc 3312361 atgagaaccc gcccctgacg tctttatata accttcttta agttctgtag gcatatttac 3312421 aattctatca tgaataagtg gatgtagtac cttaggtggc ttcccatcta tattgtttat 3312481 tccaaaataa taattgcctg tttttttgtc caatacacca gctaccgcag ggcctctttg 3312541 ttttttagtt agaccagaag atttaattct actaagttcg tttagtactt ctgcccttag 3312601 atttattcga tggtgaagat cttctttaga caatacacca tgcttatttc ttaaatattg 3312661 aagcctagtt tgtttttctt cagtagtctt agcaatattg ctaataaggc tttcattact 3312721 cactttattg acatatggag catttttttg gtacaaccga tcaaagtagt gtgccaatcc 3312781 tgctccacca ataatagtaa tagcttccag cgccccttgc ttccgcttct cctcagacac 3312841 tttgtttccg aacatatccc ggcctgtgac agcttctgag aatccgtttg acgcaacaag 3312901 gccgtatgcg cccatttctg tcattttgag aatgtctaag gatttgcctg ttttgtaggc 3312961 gtctaatgcg tgttcagcag cgatagctgc ttttccggtt ttgtagatgg cttttccgcc 3313021 tttgaaggcc cggcctgccc agccgacgac tggtatgaat ccggcagcgg ccatagctcc 3313081 tgctgtcaca cgctccgcgg tggagagttt ttctccggta accggatcaa cgccttcggt 3313141 tgctctttta taatcataat agccagtgac ttctccagta aagttgcaaa ctccatccca 3313201 tgttttttcg taccacggtt tgtttgcttc ttcctcggct ttttcctgga gccgtcttgc 3313261 ttctgcttgc tgggtttttg catcgatata ggttgttcct tgattttcta cttcaatgac 3313321 gcttttgtag acttcattgc tgtggaaggc ttttttgtca tagtacatag gggatgcgct 3313381 cttcccattg ctggtggcct gcatgagaac agaatatttg gtgagcactg cgttgtccag 3313441 agattctaaa ttttgatatt cagtggtcag ggattcatca agcttatcga cagctgtgat 3313501 tgtatcacgt ctgatttttt gggcatcgcc catcttatct gcatagtcgt caagcgtgta 3313561 catgtcgaga tcaataatat cgctgatgcc tgacaaaata gaatcgattt cttctttatg 3313621 agcggagaca atctctgagg ctttcaggtc tccattgggc agctcatgat ccaaaaaaga 3313681 agtttccaca tatgaatcat tcagttcttg atctttaata tctcctgaaa tgccgtttaa 3313741 aaacgcaatt tgagcagaga caagcgtcag ccagctgtct acgatttctg cctgtccctg 3313801 aaaaaaatct ttaatattgt ccgcgccatt tcctttaaaa ttatcgccta aatcggcaac 3313861 tccctgaaac gcttttttca gcgtattcag ctgctcttca agcgtctcat attgcttttt 3313921 tctgctcttc gcttcttcga ttaaagattt tgattcaaat actttactca tcgcactgcc 3313981 ctttctgttc tattttaccg ctatcgcctc gtcctgctct ttgagtgaat ctacgttatc 3314041 ctttgtatcc tcgatatttt tctgtaccgc ttttttgtaa tctccgagca tggttttgat 3314101 gttctcctca cgctcatggt attttttcgt ataatcgagg ctgttttttc cgttggatcc 3314161 tgcggcgccg attgatacgt cagcaagcgc atctttgaca gaatctaatg ttttgatgac 3314221 tgtgtcgtac ttcagcttaa tttctgacat aaaaaaagat caccaccatt ttagtttact 3314281 aattgtattt ccgacttctt ccgcgaactc ttctcccttt ttaagaagat ctgctgcacc 3314341 atttgctatg aacaattccg atgcatattt agctttatcc cattcaagat caaaaatttt 3314401 cccgttaatc gaagccatat actcgttata tttatcattc acaatcttag atgcttccga 3314461 tttcgcctct tctcttccct tgtcgaaatc atcggctttt gttcccgtcc aatgcttgcc 3314521 caattccggt ttcacaattt ctttgatttc agtgattgcc tcttcttgca gtgtgtctat 3314581 gtcctttttt gcttttttca gcttttcgat cttgtcttcc acgtctgaaa tttttccgtt 3314641 gagcgaactt ttgatatccg ctagcatact ttcataaccc atctgaatca cctcttaata 3314701 ctcaaaaagt cgtatggagg ggctgatgaa gatagacttt tccatacttt atttccatat 3314761 attatatttt aaaatagcca gaaggcggct taaatagggt aaatggctta atttaggcat 3314821 ataacgctct tgaaatgtag gtatttgatc ttgtttttgt tcgttataca gctaataaaa 3314881 gcgttttata aaatgaaatc acctaatgtc atagttataa aggcacttga aagaggcaga 3314941 tgttgttgat ctgcctcttt cggcgctgag cttattgttc atgtttatgt tcttcatctg 3315001 gtcggccatg tctgattttg tcatttggct tctattattc cccccttctg accctttgga 3315061 tcaaaagctt gtattagctg cagtcccagt tgtacagaac gtttgaaaag tcttttttcc 3315121 ttagatcttc aggtgtgatg aaaaaattgg cgatgccgac gtctccccac attgaatcga 3315181 tatcatcgtc tgaatcaatt tgtaacagca tgatggtgtg ttctttatat gcgtattccc 3315241 ggggatcatg ctgggtaaaa gaagcgtatc cgccaatttt atggccaaat ccgttttcag 3315301 ccagttcatt ataaatgtct tcttcatcct cgccgaactg accaaagaac tccattgttt 3315361 ccatgcccgt atactgctca aattgaaaat ctgtaggcag cacccattcc gaagatttca 3315421 caggctcgac tgccgcttct gataaaatcg gaaaatcaca ttcgcctgtg ccaataaatg 3315481 aaaaatcaga aacaagctcg tcatcgtttt ctacgatatt ttcaaaatag atcactctga 3315541 aattcttttg ttcacatcga tcgtcaaaat tcaatccata gacgtcatca tgaacagaaa 3315601 tgtagaactg caggatacct gaagaagggt agccgtcaag ctggggaatg tgcgagaaat 3315661 taatctgcgc cagaagtttc atcggctgtc cattttcgtc agtcggatat gtttcatgct 3315721 tggggaaata gggatcaccg gcaattttgc tgtcatatcg tcctgttttc ccctttctca 3315781 cattcagttt cacgtattct ttcgctgatt tctccagcaa gtcgcggtac ggtctcattt 3315841 tttcgggcag atgattcatc agattctctc cttttccggc atctccaagg ttttattttc 3315901 tggttttctt ctaatgtttt tcaaacgaat gtttaaagaa gccctacttc tgcataattt 3315961 tccaaacaat agttaaatag tagcaaatgt attcagcacc ccgcaataga tgaaaaaaag 3316021 actggtgcgc aaccagcctt tctttttcat ctattgaatt gcacctgacg gaacaaccgc 3316081 cttccgtccg acagaataat actccactcc tgcagccaaa gcctcatcca atgtgtagca 3316141 gtttctgccg tcaaatatga gcggcgtttc catcaaatcc tgataagccg ctaacgggaa 3316201 ttgtttaatg tcagcccagt cggttaaaat catgacggcg tcagaccctt tgacagcttc 3316261 ctcgatcgtc tctttatatt caacagcttg cgggagaaca tgctttgcat ggctaactgc 3316321 aatgggatcg taggctctga tacgggcgtc gagcgcagcg agacggtctg caataacaat 3316381 tgacggcgct tctctcatat cgtcggtatt cggtttaaat gacaggccta aaagggcaat 3316441 cgtttttccc gtcaccccac cgagcctgtt cagcgcttta tcaaccagca tcgcctgctg 3316501 attgttgttg actttgataa cggatttcag cagttcaaaa tcatgctcga cattgccggc 3316561 aatttgcacg agggcgtttg tgtcctttgg aaaacaagag ccgccgtagc ctatgcccgc 3316621 ttttaaaaac tggctcccga tccgcttatc ctgtcccatc ccgtatgcga ctgcttcaat 3316681 atcggcgccg accttttcac atatattcga aatttcgttt ataaaactga tcttagtggc 3316741 cagaaaagca tttgaggcat atttgatcat ctcggcgctt ctgatatccg tttggtaaat 3316801 cgggatttga aacggacgga agagctcctc cagcgtattt gctgttttct catcggccgt 3316861 cccgatcacg atcctgtcac catgaaaggt atcatagatc gccgacccct cacgcaaaaa 3316921 ttccggattg gatgcgaccg aaatactgac aggctccgct agatgttcag taatcagtcc 3316981 attaatcaaa tcgtttgtcc caacgggcac tgtgcttttc gttaccacga ctgtatctcg 3317041 tttgacatgc tttgcgatgc gtttggccgc atctgtaatt tgctccagat tggcgtgccc 3317101 gtcgcttttc tgcggtgtgc cgaccgctat aaaaatgatg tctgcctgtg ccaagccttt 3317161 ctcatagctc gtttcaaagt tcagccgtcc atcagctgta ttttttctca tcagctcttc 3317221 aagacctggt tcaaatatgg gggaaatgcc ctttctcatt tcatcaatct tgtgagcgtc 3317281 aatatcaatg caggttacat gatgtccaat ctcagaaaga gaaacacctg tcacaagacc 3317341 gacatagcct gttccgatga ctgttatatt cattgtttcc ctccaacagt taaattgctg 3317401 ctttgcagct tccgtaatat cgtatgagaa catcctatca tgaatgcgaa tgatctcccg 3317461 catagcctgt cgggtacagc ctgtacagat ttctgaaatg tgattcaacc atacaataca 3317521 ctattatatc gctctcaaaa agaaagtggt gaaatgagaa tcggctgtta aaaaaaacca 3317581 aacaattttc ttcttttgac cggctgcgga ggctgtctga agatggtctg attccgcagg 3317641 agaagctctg cattttccgt cagcatataa ggaagttccg agccgaattc tttctctaga 3317701 acataaagag cctcttgagt gtgaaaattt ctcgttttca cattatgggc atctgaggct 3317761 acgaaatgga tcaaattggc ttcaaccagc cggagagaaa atgctttcag ctgcttgccg 3317821 aagatccccg caagacttcc tgaagtaatc tgagatgctg ctcctttttc cacaagatga 3317881 tacagcaagg acgggttttc gcgaatttcc ctgttgcgtt caggatgggc gataaccgga 3317941 atatatcctt tcagctgcaa atcataaaaa agctgctccg catatcgggg aacgtgatca 3318001 aacggaaact caatcaagat gtattttgta tcattcagcg aaagcagctg acgtttggca 3318061 aggtcttgtt ccacctcgcc gtagattctg atttcctgtc ccggaagcac atgtaaagga 3318121 atgtcttctt tgattaaacg tttgtttaac tgatctgctg cttctctgac tgcggctggc 3318181 tcgtttttat acacaccgtt gttatgatga ggtgtcgcaa tgatcgtccg gattccctga 3318241 cgaacagctg ctcttgccat ttctatgctg tcggccgaat cacctgcccc gtcatccatt 3318301 gcgggaagaa tgtgacagtg aatatcgatc atgtcctagc cccctttttt cgcaaaaata 3318361 aataacgggc acgatgcacg ttatttattt ttgcatgaaa ttgtccttgg ttccgtaata 3318421 tccgtattca gagtgcttcg aaagcttttt gccgttcata atcgccccaa ggagcttgct 3318481 tttgcacgtt gcaagcgcct ctttcgcttt tgcggcttgt tctttttctg ttttcccgct 3318541 tgaaataacc agaacagaac cgtctgccac gttgcctaaa atctgtgcat ctgctacggc 3318601 aagaataggc ggcgtatcaa aaatgaccat atcatatgcc gcacacgctt cgtatgcaag 3318661 ctccttcatc cacttcgagg agagaagctc ggccgggttt ggcgggatcg ggccgctcgt 3318721 cagcacgtca agatgttttt cattcgatgc ttgtacagcc tgctccatag agcttttctt 3318781 taataaaaca gatgttaagc caaccgtatt ttcaagaaaa aaagccgtat gtactgttgg 3318841 ttttcgcaaa tcagcatcaa tcaggagcac tttttttccc tgttgggcga atacgacagc 3318901 caggttggcg gccgttgttg attttccttc ccccggacaa gccgatgtaa tcatgactga 3318961 tttcatttgc cggtccactg aagcaaattc tatattcgtg cgaatcgtcc gatattgttc 3319021 agagttcaag gatttcggct ctgtcattgc aatgacattt ctctgcatcc gcgagcctct 3319081 gttttttcta agcgccaaaa tgtccactcc ccgttttttc agattggaaa ccctgtaagg 3319141 tctttgctgt tttctgctca ttcgcaatgg tggaaactgt ccctaaaaca ggtatgtcca 3319201 gcaaggattc gagctgctct tccgatttga tcgtattatc caaatgctca agcaggaagg 3319261 ccagtccgat gcttcccgcc aatccggccg caaacgcgat ggcaatgttt agtagcggct 3319321 ttggcgatac aggggacggg tgttctgaaa cctcggcttt tgacagaatg ctgacattgt 3319381 caacattcat aatggatgtg attttgtctt gaaaaacaga tgctatagta ttggcaatat 3319441 gagccgctgt ttccgcgttt tcatccctga ctgatatgtt gaccacttgg gagtcctgtt 3319501 cgctggatac ggtaattttg tcattcagtt cttgggatgt catcgacagg cccatttctt 3319561 taatgacttc atctaagatg gcagggctct taatgatgac attgtacgta ttgattaact 3319621 gaagattggt ttggacatcg ttaaattgga cttcttttcg ttcatttttc gattggttga 3319681 ccagaatctg agttgaattt tcatagatgg gtgtaagtgc gaagaaacta atgagtccgc 3319741 cggcagcagt ggcagccgcg gttacaatca taatcaaaag tatgcgtttt gttaacgttg 3319801 ataatatctc ttttaagctt gtagattctc ccatgatacc tccaaatctc ttataacatc 3319861 cttttccatc tacgattata caacgttgaa accgcatttc tccagctttt cacgtgacat 3319921 aattcgacat ttttttacaa tgcgttatgt tagtactttt tatgtaagcg ctatatttac 3319981 tgtgttgaca gtgctgtctc attttctctt attcgggcag tcacgttctc tcgcataaaa 3320041 aaatcccgct aaaggcgtgc gggattttta tgttgcatat ccatttttaa tatgagaaat 3320101 caaattttca agcatttcct tcgtcgtcat ctcagatgac tgctcaccaa tttcatgtgc 3320161 atgcatcaaa attttcagaa attcttcttg attcaatttc ttttcactca tctttttttt 3320221 cctttcagct tccattaagt tgaaaacacg attattatat gatgctggtt atcaatttgc 3320281 aatctctaat acatcattcg acacatccta ttttttatgt ccttttttag gaaaaacttt 3320341 ttaaggccga tgtgttgcga tataatagag aaattggatc tttttattac gtgactcggt 3320401 taggagcgat aatcatgctt cagaatatga tttccaaaga cgatgtgctg gcatctgctg 3320461 aacagttaaa agaacttctt ccttacaatg aggaaaatgt tcagctgatc aaaaaagccc 3320521 ttattttata tcggcaggat tcagtctatc gtttacaagc agtgagtccg acggaagtta 3320581 cggcttacgt gcaggatgtt gtgcctgtgc gggtcacatt gaacttgttt gtcatagtca 3320641 aaagcggctg ttcatgtccg tccggaagaa tctgccgcca tatgctggct gtgtttttat 3320701 atgtatatgc aatgttcgag cgagtgggta cttttacaga gtattggctg gagagggaaa 3320761 agcttgagga aagcaaagag ctcgtccgcc gccagtttca ggaaaaggtg ctgcctaatg 3320821 aagaatcact ttcaagctgg cttgcttttt ttgattcaga gttttctctc tggcaggcac 3320881 gtacgccaga aggcagccaa aacatgcagg gcctctatta cggctacctg tccgcattaa 3320941 aaaaacatgc gccgaacaag ccggagctga aaagcctgta tcagattcat tccgcgattg 3321001 cggtttggct tcgcatgttc acattgattg aagcgggcaa gctaaacccc gaacaagatt 3321061 tttattccct caatccgtac gttgaacagc tgatggatac aatctacagc tctattgata 3321121 aattaaaaac gtacgcgctg tcttttgcgc ttgatccgtt tttggataaa acaccggatg 3321181 ttatccggca tttgctgttg aaagaagaaa ttttccaata tgaacgcatc cgcgtcttcg 3321241 gtgaaatttg gagtgcgctg ctgtcgcggc caaaatgggt ggcacgcgaa caggagatat 3321301 tgaaaaaaga agcaggacgg cgtttttctc ccgaattgca attcgggcgc ctgcatttgg 3321361 aattcctgca aaaaaatgat gacgttattt ttgaggaagc ggatcaattc ccgccggaag 3321421 cgctccctta tacattccaa tggctgagtg aaatgactgc caagaaggac tggaaacggc 3321481 ttaaaacatg gtaccagcaa attgaaccaa ttgcgatggg ttatacgaag ctggataagc 3321541 cgtttaaaga gattcgcgat gtgatcggcg agctgttcct tctgttgaat gcctatgtgc 3321601 agcaaaccaa tgatcaagcg ctgtttgagc gctttgccgc gggctgtctg ccgtatacgt 3321661 tcacagaata cagccatcat ttatatgaaa aaaaacgcta tgccgagtgg attgaaattc 3321721 atagccttgt cggcttttcc atcaatgaaa tggataaaat gatgctcaag gaaattgcag 3321781 cgagcgaccc tgaggcgctt ataccggctt accatagaga agtggctttt ttcattgatc 3321841 agaagaaccg tagctcgtac aaggaagccg cccggtattt gaaaaaattg cgcaccctgt 3321901 acaaaaaagc gaaaaagcag aaggtgtggg agcggtatat tcagctgctg agctcgcatt 3321961 acaagcgcct gcgtgcgctt caagaagaac tgcagaaagg aaagttgatt gatggcgagt 3322021 cttaaagaaa ttctcatcca cgtcgaacaa atggaagatg ggtcatttac gctctcagcc 3322081 tttgatgaga atgagcagcc tcttccctac agccatatga aaaagcattt gttccaatgg 3322141 catgaatcct cattttacgg aacctttcta gaggatgtca gcttcatcgg gacgactgct 3322201 gtccttctat ctccatggat gactgtagag cttctcggca aaaactcgtt caactcattc 3322261 agctccgtgc agcttacaga agaaacggag ccgctgatcg aggcggcatc gaccatctat 3322321 gaatttatcg cggacggcga ttttatgcct gactatgacg catggacaaa cggtgttttt 3322381 cgctggaagg accgcgataa tatactggaa ggctttactg cggaatggtt ttccgctgcc 3322441 gtacaggatt acatccagta cgacgatgac ctgcgggaga aatgggaaca tatcaaggaa 3322501 aaatcgcctg cggttacgac attccgtggc cattttcttg atgaagagga ttttctggaa 3322561 ggcattggct ggattgacga tcaatctcca tttactgtcg gcttgcgctt aaatgaaccg 3322621 gactttgacg gagacgaatg gaagatcgag atgtttttac gcgataaaaa gagcggtgct 3322681 gtagaattct ttgacggact gaagagcctc aaaaaatcgt ggcaggcgta cagcgataaa 3322741 atcgcgcgtg agcaggaccg ctttcacaga acggttccgt ggctgtcgtt tgattccggg 3322801 acaacgctga tctcggagga agaagcctgg atcttcctgt cagaagcaag tgagacgctt 3322861 gtcgatatgg gggtagaaat cctcctgccg tcctggtggc agattgtcag agacagcaac 3322921 atgatgctga aagcaaaggt gtcttcctcc ccgcgcggcg agtcatttgt cggcatgaat 3322981 gcactgcttg atttcaactg gcggtttgcg acaaatggaa ttgaactgac tgaggctgaa 3323041 tttaatgagc ttgtcgccag caacaggcgc cttgttaata tccgcgggca atgggttaaa 3323101 atcgatccgc agtttatcaa acagatgaaa cgcctgatgg aaaaagcaga atcagaggga 3323161 ctccacatgt ctgatattct ggcgcgggag ctaatggatc agcaggatgg cggacttgag 3323221 gattcggacc tgattgatac atctgctttt gccggcattc agtttgatct gtctaaacag 3323281 ctcaggtcac tgattcgaaa gctcactgcc gcggaaaacc tgccggagca caaagtcagt 3323341 ccttctttca aaggaacgct ccgcccttat cagaaatacg gcatgaactg gctgctgttt 3323401 ctgcgggaaa gcggttttgg cgcctgtctg gctgacgata tggggcttgg gaaaacgatt 3323461 caaatgatcg cctatttcct tcacgtgaag gaaagcggcc gacaaaaaac gcctcatttg 3323521 attattgcgc cgacatccgt acttggcaac tggcagcggg agcttcaaac ctttgcccct 3323581 gatctgtctg tcgcgctcca ttatgggccg cgccggccaa agggtgatga tttcgccgcg 3323641 cattatgaaa acgcagacgt ggtgctcact tcatacggtc tgtcacatgc cgatactgaa 3323701 gagctttctt ctgtgacatg gaacacgatc tgccttgatg aagcgcaaaa tattaaaaac 3323761 gcgcatacga agcaatcacg cgcaatcagg aagctgaagg ggcttcacca tatcgcgctg 3323821 agcggcacgc cgatggaaaa ccgactgact gagctgtggt ctatttttga cttcatgaat 3323881 aaaggctacc tcggcagttt gaccggcttc cataaacgct atgtgctgcc gatcgaaaaa 3323941 gaccgggacg aaaagagaat cggacagctt cagcaattaa tccggccatt ccttctccgc 3324001 cggacgaaac gggatgaaga ggtcgcgctt aatcttcctg agaagctgga agaaaaagaa 3324061 tttatccctc tgtcagccga gcaggcatcc ctttatgagc agctcgtcaa agacactttt 3324121 gaccatatga catccctgac cggcatgcag cgaaaagcgc tgatcctcag catgcttgga 3324181 cggctcaagc aaatatgcga tcatcccgcg ctttatttaa aggaagagca aaccgagctg 3324241 ctggccggca gatcagtcaa gctcgaaaaa ttgctggaac tgatgacagc gatccgcgcc 3324301 caaaacgaaa gctgcctgat tttcacgcaa tacattcaga tggggaacat gatgaagcgg 3324361 ctgcttgaaa aaacgttcgg ggaacctgtg caatttttaa atgggagtct ctccaagcaa 3324421 gagcgggata cactcgttga gaaatttcaa aggaaagaat atccgacact gattctttca 3324481 ctcaaagctg gaggcaccgg acttaatttg accgccgcca atcacgtcat ccattatgac 3324541 agatggtgga acccggcggt tgaaaatcaa gcgactgacc gtgcataccg cataggccag 3324601 gagcgctttg tccacgttca taaaatgatt acgacaggaa caatcgaaga aaaaattgat 3324661 gtcatgcttg aatccaagca aaccctgaac gatcaaatta tccaaagtga aaactggatt 3324721 accgagcttt ccacacagga gctcgaagaa ttgtttacat taagcgctac agcgcaataa 3324781 tcatgactaa aaaagctggc tctaaaagag ccagcttttt tccgttcata gccgtcacgc 3324841 cgaatttcca aaaaatccgt tacgccggtt atcaacaggg tgcgcttttg tggcagcaca 3324901 tatacttaca acaaatgttt catcatatgt gcgacaccgt gttcgtcatt ggttaaggtg 3324961 acagcatcgg ctatcgattt gatgtcttcc cgggcattgc ccatcgctac accttttccc 3325021 gcagcctcca gcatcgattt gtcatttaaa ctgtcaccta cagcagcagt ttcctcgagc 3325081 ggaatattca gctgttttgc aagcctcttc agcgcctgcc ccttggaagc tttgcgggaa 3325141 gaaagctcaa agttgtgctc agccgaactg acaagcgtca aatcttcggc atgctcatat 3325201 cttttccagc ctgcctcaag cttttctttg aagaaagaaa agccgagaat attgtaaaaa 3325261 tcgattggct catcggcttc aaacagctct tgaaaggagt taatgtaagc aaagcccgat 3325321 tggctgtatt gcacctcggc cgcctgctta aggacagaaa gatccgcttc cggatttgcg 3325381 cttctgaatc tgtcgagctc aacatcaaga agttctctgc cgttttgcgg cgtataaatc 3325441 gctgaacctg tgaatacctc ataataatag ttttccgact caagccatga gagaatgtca 3325501 tacgcccgtt tcttatcaat cgtttcgtga tgataaagcc tgccctcggg atcgtgaatg 3325561 acggcgccgt ttgcactgat gacccatgtt ttgatcccca gcggttcaaa gattgacatg 3325621 acgtcaaaat gagcgcgccc agttgacacc accacttcaa tgccgtcccg ctgcgcctgc 3325681 cgcagtgcgt tttcattttc caagcttacc tgatgcttgc tgttgagtaa ggttccatct 3325741 aagtcaatcg caattaattt cacgtttgtc agtcctttcc ttcatcctgc tctgtcacga 3325801 gaagctcaac gccgtttcgg tcaagcaagt cacaaaatgc ctgattcggc agcctgtctg 3325861 taatcaagag gtcgatttca ttcagctccg catactgata aaaactggtg ctgcccagct 3325921 tagaatggtc tgcaagcgca attacctgct ttgcctgctg tatcattttc cgcttcacca 3325981 tgccatcctc ttcatgcgca attgtaatgc catgttcgga aatgccgacc acaccaatca 3326041 gcgctttatc aacatggtag cttgagagct tttcaatcac agaggacccg tacagaaagc 3326101 ggtgctcctt ttccagcttg cctcccagca gataaatttc aattccctct ttatcggaca 3326161 gcacatccgc aagattaatc gaattggtga ttacggtaca atcaaccgca ttcaaatgct 3326221 ttgcacatgc ctgaacagtt gtagaggcgt ctaaaatcac ccggtctcca tcatgaataa 3326281 gcgatgctgc aagcctgccg atcttatttt tttcctcaga cactgttttc aggcggccgg 3326341 aatagctttg aattttctga tgcacagtcg gtaaaatggc gccgcctctt gtgcggatga 3326401 tggcattctg ttcctcaagt ttcacaagat ctcgtcgcgc tgtatccctt gacacttgca 3326461 ggagcgtaca gatctgctcc gttgtaattc ggttatgctg ttttaaaaaa tccaaaatcg 3326521 ctactaatct ttcttcttgg tacacgccct cattcctttt ctcagcaatc atttataagt 3326581 aattataagt ttttatttga ttttattcaa cattaataag tgattttaag taaaaatgcg 3326641 tcgagagaac caatttttcc taagtaggca aaaagaaaga accagtctgg tcgactggtc 3326701 aattttgagg ggatgatgcg aagatccgga taatagtgaa tggatagata acgggaggag 3326761 caggggtgtc aatcagcagc tttttcccgg ggtttagggt ccataaaacg aacagtgtca 3326821 gccaacactt ctgttacata cacgttaacg ccttcctcgt tttcatagct tcttgtctga 3326881 atccgtccgc ttacgccgac gagagaacct ttttggcaat acaacgccgt gttttcagct 3326941 gtttttctcc aaagtgtgca attgacgtaa tcagcttcga tttcacctga agcattcttg 3327001 aagctgcggt tcaccgcgag cgtaacatgt gcaactgccg caccggcgga agtgtagcga 3327061 agatcaggat cttttgtaag acgtccgaca agcatgacct gattgaacat gcgattcctc 3327121 ctctccttgc ggttgtatgt attgtaaatg atgcaacaag aaaagaaaaa cgcttaaaaa 3327181 tggctttcag cctctgtttt tatctttcgt tttcattttt ccttcagcta aaaacatctt 3327241 ttgctttttt cctttgaaga aatatgtact ttttaaaaaa cggaaaaaga tttgctttgt 3327301 cagccagttt tgcgtattca tgcgcacata ggaagagcca tcccacgcaa accactgaaa 3327361 gctcaatttt ttttccggca ttgacagctt gattttatac tgctccatgc catcttgtgt 3327421 ttcgtataaa aaacttattc ttcctttttt gttcagatga acctcaaaca cttctttacg 3327481 gcttaacata tatgttactt ccttttgaat caaatgactt tcagaaggaa cgccgtcaat 3327541 ataaatttct tttaaacgaa attgattcat accacatctc tccgtaatcc atagtcagtt 3327601 acagtataat gaaaaaatag aaattattaa atgtttcgct catacaaaat tctttagccc 3327661 caacattgca ggattttttc ctcgaaaacg tttatgttat aatggaaggc aagaaaactt 3327721 tggaagtaat cggggtgaga agaaatgaaa acctttaaac tggttgacct gaatgtggaa 3327781 cgagtggaca aggaagaaca atcaattgaa cagtttcccc ttattgacgg actgattata 3327841 aataaagaag acggtgaaaa tcactggctg attgaggcgc ttgtacagaa agaacatctg 3327901 tctttttttg aacagcttca aaacagccaa tctgaagcca aagtatttgt aacgatcacg 3327961 aaaaaaagca atcgccccgc ccagctgaca gcagcagtga aaaatatcgt caagctggaa 3328021 gaaagcattc aggttttact ctacggacaa atggtcacaa gaaaacagca gggcactgaa 3328081 accattctcg agtcccttgt aaaagagggc tatacaggaa caaaactcat tgaggcattt 3328141 aagcaaaaat tataaatatg agggggcatg ttccccaaaa cagactcaga accgaagagc 3328201 atcacaatag acatttagaa tagatatgtt ctgcatgaaa aaagctgccg ttttgaacgg 3328261 cagcttttct cttcgtgctt tcactcttgc atatttaatt tgtatggcca aaagaatcaa 3328321 ccaattcccc tttcacaacg aggcgccctt cggttttgac cgccttgtca catgtgatta 3328381 acgtaatctc ctttttgttt gtctcctcaa ctacatctgc atccatttcc gatatgatgt 3328441 ctttcgatgt tacagaatag atataatcct ttttaaaatc cgtgatgaca atttgggcac 3328501 ctgtttttat gttttccaga ggtccgaaca gaagattctt ttgcttcaaa tgatggcccg 3328561 ccaacggata atttccctca cccatttttt gatcccggcg cattgttgcc gcccctatca 3328621 aaagattttc attggttgtg ccttttacga tcggaagctc cagatcgaca cttttaattg 3328681 ttatccgccg ccttgattgt gaagtaaaaa taagtatatt tcacgtgctt tcgacgttct 3328741 ccacttgact ggaatgcttt aatggcgatc ccggcatctg tagcttcagg ctttccttca 3328801 gaggaatcag aaatctcaaa ctctattttc tcagtgttca gcacataacc ggctggcgct 3328861 ttcgtttcaa caaaagcgta ttgtcccggt gcaaggcctg aagctgtgac ttgatgatgc 3328921 cggatatgac tggtttcgaa gtctgtatga aaattcgcga acgattcagc atggttgatc 3328981 ttccggttct gatcattaca gctgccatta tcggccatga caaatacaag gcttttcatg 3329041 ccggagcgaa tgacattttg caaaaaccct atcattactc tgaatttatg gcgcgtattc 3329101 aaaacctgat aatgatgaaa catacagcaa atcaagccac aagaatggaa atggcgtttc 3329161 tccagtcgca aatcaagcct cattttcttt ataatgtatt aaacacgatt atttctctca 3329221 ctcatttgga tattgaaaag gcccgggagg taacagagga atttaccaac tatttaagaa 3329281 tgagttttga ctttcaaaat acatcagcca tcagttcctt cagacatgag ctttcgatta 3329341 tcaattccta tctttctata gaaaagacgc gattcagtaa tcggcttgag gttcttttcg 3329401 atatagatga agacattgac tttatccttc cgcctttaat gattcagccc ttggtggaaa 3329461 atgccgttct tcacggtgtc agcaagaaaa gaggcggagg atggatcaaa ctgacagcta 3329521 aaaaacaaag caaaaatgag tatcacatca aagtagagga taacggtccc gggataactc 3329581 cggaaaaaca aatagatctc ttatcaacgg attttgatcg cagcgtcgga ttgaaaaata 3329641 tcaatcagcg gctgaaacat ttttgcggaa gcgagttgat gatcagcagc actccggatg 3329701 caggcacctc tgtctcaatg ctcattcatc tcgctgaaac aacaggaagc cctaaagaac 3329761 tgaaggacac agaacgaacc taaacgaaaa ttgagataaa aaaagacgcc gtttctaacg 3329821 gcatcttttt tattccggcg actttgcttg ctgcttcagc aggtctctga tttctttcag 3329881 cagctcctcc tgcgcatcca ccgcttcctc cgcagcctct tcttctgctt cttttttgcg 3329941 ccttaaccca ttcaaagtcc gaatgacgat aaaaatggag aacgatataa ttaagaagtt 3330001 cacaatcgtc tgtataaagc tgccatattt cactacagca tcgccaaacg taaacgacag 3330061 gcctgaaaag tcaagccctc ccagcagcaa accgaccaaa ggcataatga tatcatttac 3330121 tagagatgtg acgatctttc cgaaagcgcc gcctatcaca acaccaatcg caaggtctac 3330181 gatattcccc cgcatggcaa aggctttaaa ttcattccac atacaatcac ctgcttttct 3330241 atatttgtaa agaaaaaaag acaaatgtgc cgctggccat ctgccttttt tcaattattc 3330301 tccgagggca aaagtcagtt ctacttcgca aacgacttcg ccatcaactg tggcaacgcc 3330361 ttttccgcgc ccgattgtgc cgcgggcacg aatgatttca acctcaaggt gaagctggtc 3330421 accaggcttg acttgttttt taaagcggca gttatcaatg cctgcaaaaa aagccagtct 3330481 gccgcggttt tcttctttaa tcaacatcgc aacagctccg acttgagcga gtgcttctac 3330541 gattaatacg ccgggcataa ccgggtactg aggaaaatgt ccgttaaaga actcttcatt 3330601 agcggttaca tttttatagc cttttgcccg tttgccctct tcaacttccg taatccgatc 3330661 cacaagcaaa aacggataac ggtgaggaat aatttcttta atttgctgag tatcaagcat 3330721 tgtcttgaca tctccttcat ctgcattagt atgtatagca atcatcaaag atccaatctg 3330781 tacatttgaa aagtatatta tgaattaatc tctttttcaa ccgcgctaaa atgtaaccaa 3330841 ctgtcaatga gagccgtcaa aagttatgat atgataatta tagattttac caatagcaaa 3330901 gaggtaggaa aatgatttcg aagtttattg aaaaaagaat gctaaacatg ttagacgagt 3330961 ggtattccgc aatgagcaaa cgcaaaatga atcacgtttg cacactgaaa gagaaaattg 3331021 atcagcacct tccaaagatc aaaaagaaca caaaactttg gatgcgttat caattgtttc 3331081 aggcccgcca tcagctgctt tttgaaaacc agaacggact cgattcattg ttcgatggcc 3331141 tatatggcct ggaagacaaa atggatgatg aattgaaata ttatctgtat tttttctctg 3331201 ggttatatga gatggtaaaa acagctccga aacatgcagt acatcatttt aaaaaagctg 3331261 aacagtacct ggccgccatt cacaatacgt ttgaagccgc tgatttatat tatcaaaccg 3331321 ccggcgccta ttacttgatg aaatcaccgc cgctttccgt ccaatacgtc aaaaaagcat 3331381 tacacatcta tttgcaccaa ttcggctata tcaaaaaggt aatcacctgt aaacttttgc 3331441 tcgccgtgaa ttatattgat caagaacgct atgaaaaagc tgaacagctt ttcaaagaaa 3331501 tcattaagaa aacccagcaa ctacatgacg aaaacctgct atgccacgct tattataacc 3331561 ttggcttttt aaaagcgacc gagaaaaaag accaggaagc gcttctttac tttagaaaag 3331621 tattaaagaa tcaagaattt gaaatgaatt caccagtctc atatcttcat tgtgtgtacg 3331681 agtctgtcag agcgcttttt aaaacaggga acatcacaga agctaaagcc gtccttcaaa 3331741 aaggaaaaga attatctgaa aaggtagaca ttcaaaccat ttatttaaaa ttaaaaacgc 3331801 ttgaagccct ctacacatca gccgaagacc cttatgagca gctgctcgaa tatgtgcttg 3331861 aattagaaaa aatcgaggcg tgggtggatt tagaagtgct gttagaagat attacggaat 3331921 actacaaaaa aaaggacgat ttcgaaaaag ccgctttttt tatcatgcgc ggctgattga 3331981 aaaacgccca ttttcttatt atctgactga attgattaaa ccgagcattt gatctcccat 3332041 tgtgatcgtt ctgctgttca gctgatatga acgctgggac gtgatcaaat ctgtcatttg 3332101 ttctgaaata tcgacattgg acatctcaag tgagccctgc tgcatgccga tgttttgtct 3332161 attagcgccg ttcagctctt caaaagctgc cgcattatca atagagaaaa ggttattccc 3332221 ttcggatttc agctcttgag ggttattcac ttggacaacg ccaagattaa accgctgaac 3332281 cgcgtttccg tcagatgcgg ttaaggtgcc gttcttatta atggtgatat tcttcattga 3332341 gctgtcgatg ttcactgtat tgccgttctc atcaagtacg ggatacccat ttccagtgac 3332401 gagctgcagc tggttggcat tcgcagcgga cggcgttaca tacagcgccc cgtccctcgt 3332461 atactggcgg tttccattta catttacctg aagatactgg tatggagacg taaatgcgat 3332521 atccagatcg cgatcggtct tctgaatgct tccttgatca gagactaggc gtgaactcat 3332581 catcgctccg acgccaaggc gcaagccggg cggcgttttt cgggcttttg ccacttcctc 3332641 gtttttttca tcaacctgat cgaattgctg tctgacaagc tcagaaaaat tcgtatcttt 3332701 tgccttatag ccggttgtgt tgctgtttga aaggttgctg ctgattgtgt caatctgctg 3332761 ctgcagctgg tttaaggttg ttgatgccgt tagcattgac ctgagcatag ttgatgtccc 3332821 ccgttttttt cttccgtttt cttaaatttt tccaatttca tttgctgctt tatccatact 3332881 tttatcgtaa gcctgaataa ccttctgatt cgcctcaaac gatctgtacg cttcagtcat 3332941 ttctgtatag gcgcttgtca catccacgtt tgaaagctct gagacgcctt gttttaatga 3333001 ataggctacc tgattatttc cggctgcgct tggcagatca ttaccgtccg ccgtgctgta 3333061 caaatcattt ccgtcccgtt tgagattgcg gacatcttcc gccattctga catcaatctg 3333121 gccggctgtg cgtccgttcg ttgtcacagt accgttttca gacacagtga aattctcatt 3333181 atcaacagtg attggctggc gatccgtcga taaaataggg cgtccgttga tcgtcagctg 3333241 attgttctca tttagtgaaa atgtgctgct ttttgaataa cggattccat ccgctgtttg 3333301 aaccggataa aaaagagcag ctttttcatt ggtttccgca ctcatcggaa cttgattttc 3333361 gatcaatgca atgtctgtag gctggtctgt ggacttcagg cttccctgtg taaagagagg 3333421 cttgagctcc tgcatatata ctccggtatt cacggaaccg atttccgtcc ttgatgtccc 3333481 ggccggagat tttgattcta ttctgctgag cagcatctca gggaacgcgc gcatagagcc 3333541 ttgatcagct ttatatcctg atgtatttgc gttagcaata ttatttgaaa gcatttccgt 3333601 tcttcgctgc tgggcaatca ttgcggatgt tgctgtatat aatcctttta acaaatttcc 3333661 cacctctaaa aatggcattt tttccagttg tcatatagga acgttcgttc tataataaaa 3333721 actcagtatt ttatcctatt atcgtcattt aacatctttt cgtgaaggct ttttcataaa 3333781 aaaacctcat tctttttcag aatgaggttt gtgaaatcag cttagtttgc gtttaggaag 3333841 cttgtccata ttatcaagca tgacacctgt gccgatggct acgcaatcca taggattttc 3333901 agcaacgagg accggtacct tcagctcttc agcaagcagc tggtcaaggc cgtttaagag 3333961 cgcgcctccg ccggtaataa taacgccgcg gtcaataata tcagcagaaa gttcaggcgg 3334021 tgttctttcg agcacttgtt ttgcagcctg aacaataaca gcgacagatt cacgaagggc 3334081 ttcttcaact tctttactgt ttactgtaat tgttcttgga agaccggaaa ccatgtcccg 3334141 tccgcgaatg gaaatttcct cgtgacgtgc gtctgggaaa acagttgcga ctttaatctt 3334201 aatatcctcc gcagtacgtt cgccgatcag cagcttgtac tcgcgtttga tataatttaa 3334261 gatttccatg tcaaacttgt ccccagccat tttaatagaa gaggaggtga caatatcgcc 3334321 cattgaaata accgcgatat ccgtcgtccc gcctccgatg tctacaacca tgttaccgct 3334381 tggctggaat atttccatac ccgcgccgat agcggcaact ttaggttctt cttcaaggta 3334441 cacatgtttc ccgccgcttt tttctgcagc ttctttaatt gctttttgct caacggatgt 3334501 aatattcgtc gggcagcaaa tgagcatgcg cggctttgag aacaggcctt ttacattcag 3334561 cttgttaata aaatgtttca gcattgcttc tgttacttca aagtcagcaa taactccgtc 3334621 tttcagcggg cgaatcgcaa caatattccc aggtgtacgt ccaaccattc gtcttgcctc 3334681 ttcgccaacc gccagcactt tgccgctgtt tttatcaagt gcaacaacgg aaggttcatt 3334741 cagaacaatt cctttacctt taacatggat cagtacattt gcagtaccga ggtcaatacc 3334801 aatatccctt gcaaacatct atttatatcc tccttgaaaa tctgtttcac agtaaatatc 3334861 cacattgtgc cctaattata tatattatca taaaatatag aaaaaaagtt ggaagcacaa 3334921 taagttcttt acaaattttt gcggatgttt tatgaacgat ttcaagaagg caatgccagg 3334981 tgattacgat tgctgaacag gctctccttc gagaatttca tcttttttat atttgagctt 3335041 tgtcgcttct cctcctctta aatgcctgat ggatttatga taatcgagta tttctttcac 3335101 ttcgtttgcc aagtcggggt taatttcagg cagacgctct gttaaatcct tgtgtactgt 3335161 acttttggaa acaccaaatt ccttcgcaat gacacgaacg gttttctttg tctccacgat 3335221 gtacttccct atcttgattg ttcgctcttt gatgtaatcg tgcacaccac tcgacctccc 3335281 taaaatggat gtgagaagtg tgaaatgaga tccgtattct gtaaagagtc gttcattatg 3335341 ccgcttcttc gttgtatggt tttaaaagta agtttgtgaa atatgcccac gatccctcac 3335401 ctcaaacact ctctttgtta ggtttgtaac agtgtattag cattcttttg ggaatatgct 3335461 aaaaactcaa taaggacaag gggtgaaacg aactttttca gattcagcaa actatttcgc 3335521 gtcactaaat tttcatcttt acaactattg atcgctcctg taaaatgaaa taagcaatta 3335581 gttacttagg taagtttttt agaaggagac cgacatgtcc tacgtcaaca gacacctcat 3335641 tcatcaaatc aaccaaagcg cccgcctgat tgccaagaaa gccaatgaac agctagagcc 3335701 attcggcctt tattcatctc aatggtcagt tttatattgt ttgcgtacga tcggaccaat 3335761 gactcaaaaa gagatttggt cctatttaaa tgtggaagcg ccgactgtga ctcggacgat 3335821 caaacgcctg gaggagaacg gctgggttca gagacggcaa ggtgaagaca aacgggaaaa 3335881 acttgttgtc ctcacaaaag aagccgagaa aaaatacgaa gaaatcaatg tgaaaatgtt 3335941 gaaattcgag gaagagctgc ttgcagattt ccgggatgaa gataaagaag ctttttctca 3336001 tttattccgc atgtttttac aacaatgaaa ataaggaagt gacatacatt tgaaaaaagc 3336061 ggatgcgata tggaccaagg attttattat ggtcctgctt gtcaatttat ttgtgtttgt 3336121 gttcttttat acatttttaa ctgtattgcc gatctataca ctgcaagagc ttggcggcac 3336181 agaatcacaa ggcgggcttt taatcagcct gttccttctg tctgcgatca ttacacggcc 3336241 tttctccgga gccatcgttg agcgtttcgg gaagaaaaga atggcgattg tatcaatggc 3336301 gctcttcgcc ctatcatctt ttctgtatat gccgattcat aacttttccc tgctgctcgg 3336361 attgcggttc ttccaaggga tttggttcag cattttaacg actgttacag gtgcaattgc 3336421 cgctgatatt attccagcca aacggcgcgg tgaagggctt ggatactttg ccatgtctat 3336481 gaacctcgct atggcgatcg ggcctttcct tggcctgaat ttgatgagag tggtaagctt 3336541 tcctgtattc tttacagcct ttgcgctgtt tatggttgcg ggcttacttg tttcgttctt 3336601 gataaaagtg ccgcaaagta aggacagcgg cacgactgta ttccgttttg cgttctcgga 3336661 tatgtttgaa aagggcgcac tcaaaattgc gacggtcggt ttgtttattt ctttctgtta 3336721 ttcaacagtc acatcatatc tgtctgtatt cgccaaatca gttgaccttt cggatatcag 3336781 cggatatttc tttgtttgtt ttgcggtgac aatgatgatt gcacgcccgt tcacagggaa 3336841 attgttcgac aaagtcggac cgggcattgt catttatcca tcaatcctga ttttctctgt 3336901 cggactctgc atgctgtcct tcacacatag cggcttaatg cttctgcttt caggggcggt 3336961 tatcggtctt ggctacggat caatcgttcc ttgcatgcaa acattggcga ttcagaaatc 3337021 tccggctcac cgctccggtt ttgcgacggc aacgttcttt accttctttg acagcggaat 3337081 tgctgtagga tcgtatgtat tcggattgtt tgtagcatct gccggcttct ctgccattta 3337141 tttaacagcg gggctgttcg ttttaattgc tctgcttctc tacacgtgga gccagaaaaa 3337201 acctgcagag gctgaaggaa aagtgtctat tgcagaataa cttgtcagac tgccgggaaa 3337261 tcccggcagt cttttttcca ttaaaacacg gcgccctctc ggttgaacga gagaacgccg 3337321 cttatagcaa ttattcaatg acaggccgcg caggtgaatc aggatctaac gaaaaatcat 3337381 aggacgcttc atcacgaaac atcggatcgg catatatgga ttgttgatcg ttttttgttg 3337441 cttttcgata cgaagaaaat gaatcatatt ctttcttttt ccacatccat atgccgtctt 3337501 gatccgcttc cttgtggtac acgttatgat tgaccgtatt accttcgttt tctgtaaagt 3337561 cgtttccgat aaataatctg gaatcaccgg ccgtcaatat attcttttca attgtgttgt 3337621 ttttcgtatc gtactgcagc agcagctgtc cgccgtacag tccctttgtg tcattccggt 3337681 acataatatt gcgggcaatc agagaattgc tggtgccgcc ccgctttttg tcatatcctc 3337741 cgattgaaat accggtgtac gcattgttgt acactttgtt gtctgtgatc tgaatggcat 3337801 ttgcatactt tcctttgtgt tcagacgttg cttcaatccc aatatcgtta tcgtaaactg 3337861 tgttgttctt aatttcgata tcgtgtcctc catcgacata aatcccgccc gctgagtatt 3337921 catctccata agcaggattg ccgtaagtcg agttttgata aactgtattg ttttctacga 3337981 ctccgtttcg cacgtaatcg tttttatccg cggttccctc ataaccaatt agatcaatcc 3338041 cgatgttatt attgttgcgg accacattgc ctgcaactgt gaagccgtcg atattaccgt 3338101 tcagcacaac tgcttcactc gctccaagcg tcagtttctc aactgtattg tcctcgattc 3338161 ggatgtcttt catgctgcca gtcccataaa ctgcgattcc gtgagcattt ccttcatccg 3338221 ctgttgtctt aatcccccgg atgtgattat ccttaatggc gatatgactg ctggaccctg 3338281 atacataaat ccctatagca gttgcttcct cagatgaaac agaaagatct tgaattgtta 3338341 aaccgctgat ggcaatgtca tgtttatcgt gaatacgaat aagcggtgtt tcatattcag 3338401 cgttcgcaac ggattcaccg ctaatcacga cgttttcatt ttcatagttt cggaatgtga 3338461 taggctttcc gtccgtaccg ctgtgcttta catcaagggt ctcatgatac gtgccctccc 3338521 gaatcatgac agttgtgccg gcagcagcct tctcagatgc gtgtgccaat gtacgaaacg 3338581 gcttttcttt tgttccttca ttttgatcac tgccatttgg cgaaacatac agataatccc 3338641 cagatccttc ctcattcgct tttgtcttat cataaacgaa agcgaggatg acagacgtta 3338701 aaacacccgc caaaagaata aaataccatt ttctcatttt cgattcccat ttcgttttag 3338761 aatagatttc taaaaccatt ataaatgttc tatttatgga aaaccatttc aaaaatatga 3338821 aaatataccg tctaaataga tcttattcag cctggcggac ctgcgcatgt tcaactgttt 3338881 caattgccaa tgatgcaggc gggtgaacac gcatcagaac aatgtagaaa agaaaggaaa 3338941 tcagcacacc tacaaaccaa gaaatatcgt ataagctctt caatacagga acatacatgc 3339001 caatcagcga aatcagcgct cctaacattg tggctgcaaa cgcacggtaa ttgtagccct 3339061 tccaatacac ataccgtcct gtttcggaat acaggtcatc taccgagagc tcacgtttgc 3339121 gaatgataaa atagtcggcc atcatcacgc ctgccaccgg tccaagcatg ccgcctatta 3339181 agccaagaaa cgcatacacg cttgtcgcgc tctccatcag cttccacgga accgtaaata 3339241 aagcgagcaa cgctgtgata aagctgccac gtttgaaatt gatatatttc ggcagggcat 3339301 tcgctatatc ataagcgggt gatacgatat tcgccgcgac atttacagag atcgtggcga 3339361 tgcagagtgt gatcacggac aagacgatga cataagggtt atcaaaccgc gccaaaatat 3339421 cgacaacatc ccaaatcggc tctccgaacg cgacctgcga gccggaggtc accgtaatac 3339481 ttgcgaatgc gaacagcgca aacgttcccg gcaaaccgta aaattgtcct ttgatttgct 3339541 ctttttgtgt ttcagcaaac cgtgtaaaat caggtatatt taagatcaat gtcgcccaga 3339601 tgccgatgat gccagtaact ccggcagcaa acggccagaa tgtttctgaa aacgtatgaa 3339661 actttcctgg ttgagagtat atcgggccca atcctccagc aatatcaacg gcccaccata 3339721 ccatgccgcc aaataccaga tacactaaag gccctgccca cacctcaaaa cgtttaatcg 3339781 actccatgcc gtgatgcaat acgagtaaat gaatggccca aaagaataca aaggaaagca 3339841 aaccggacaa gtgaatgccg agaatgttcc actcgccgcc aatttctccc caacctggcc 3339901 acatattcaa aagcaaaatg ttcagtgccg tgctacccgc aaaggtctgg atgccaagcc 3339961 acatgatagc tgtaaacgcc cttagaagcg cggggatatt cgcgccgtat atcccgtaag 3340021 aagcccgaat gatcactgga aacggcagcc cgtattttgt ccccgcatgg ccgtttaagg 3340081 caagagcgcc aaataggata agtgatgccg taataatgat cgccagcacc tgccaaggcg 3340141 aaaggccgat cgcaattaat cctcccacgg tcgcgtaggt cggtatgtta tgtatacatc 3340201 ccatccaaat ggaggcaaag ttcattgctt tccacgtccg tttttcctgt cccaaaggca 3340261 ccagatcttc attgctcagc ctgttggatt gctgctgact ctcttttaat ttcatagccg 3340321 gctccccttt ccatattgtc tatatgtcgt cacacgttat gttttttgac attagatgtc 3340381 acttaatata actgaagagt cagacaataa cactggctat gatatacaat tttcccgttt 3340441 gtatttgaac agcttaaaca agaaaaagag acagacctca gagcccgtct ctttcttaag 3340501 atgcagtttt cattaatgca gcaaatctca cagccattaa caggcttgct ccgcccgcta 3340561 taatcataat gattcccatc atatcaaaat gggctgccgt gatttcttta ccaaaaagaa 3340621 tgccaaggat caccgaagac aaaatcgatc ctaggtaacg gcaggtttga aacaggcctg 3340681 aagtcgttcc taccatgttg gaaggactcg tttccagcat cgctgcctga agcgcgacat 3340741 tgcccagtcc gtagcctata cccaagagcg acagaatgag gcctttaccg atggtctgga 3340801 cattgataaa aaagatggtt aagagcacgg ctccagccgt catcaaaagc gctcccgcaa 3340861 agatcggctt gacgacacca gatcggtcga tccatttgcc ggttagaggt gacacaacga 3340921 tgctcattcc agacataaac agcataaaca ggccgctcgt ttgaacagaa agatgcattt 3340981 catcctgaaa gtaacttggc aaaccaaaaa ataaacaata gaagaaaaca ttcaataaaa 3341041 taaactgaac atacacggct gacaggtttc gctgtgtttt aaacagacgg acatcaataa 3341101 acggcttatc cgttttcagc tcgcgccaga caaacgcaca gagcagaagc aagccaagca 3341161 caccttcaac cgcatgcggc gacgtgctga acgacagcaa aaaggataga aggaaaatga 3341221 ttcccccggc aaataaaaca attccaagaa tatcgagctg ccgaataatg gttttgattc 3341281 ctgccccttt tttctgatct ttcgggaaca tatacaggcc caataagaag ctgaggataa 3341341 taaacggcaa attaacgata aagatcgccg gccagcctcc ccatacaatc aaaaacccgc 3341401 cggctgtcgg ccccagcgcc gtcatggcgg acgcaaaaat agagagtaca gccaaggctg 3341461 aagcttggcg ctcatgaata tgattccgaa tcaagccgac acctgacgga taaatcgcac 3341521 tgctccccac cgattgaaac agccgcatga ccaataatgt cataaacgtc ggcgcaaacg 3341581 gcgccccgat ggcagaaacc gcaacaagaa taagcccgaa taaaaacaag cgtttccgcc 3341641 caatcaaatc accgagcttt cccgttacgg gctgcgctac ggcactcgcc aagtaaaacg 3341701 aggaaatcag ccaggaaacc gttgtaaacg agaggtgaaa ctcatgctgg atgctatgga 3341761 gcgcaagaga gatcatagac gagttcagcg gattcagcat tgttcccgaa gccacagctg 3341821 ttaaaaaaac agctcggctt tttttcgata acatcatttc acttgttcca gaaactcttc 3341881 cgttgtccgc gatttaccga ttctcgggaa aataaagcgc agtgtggctt catgctcttc 3341941 atcgctaaat gtggacatgg catctgtaat aaaaatctgc tgatagccaa gctgaaatgc 3342001 ctcccgtgct gtgctttcca ccccgatatt cgttgcgatg ccgcacaata caatcgtatc 3342061 aatgccgcga cgtctcagct gcaagtctaa atctgtgcca aaaaaagcac cccattgccg 3342121 ttttgtcaca gtataatcgc catcctgcac accgatttcc ggaacaaatt cggcccagtc 3342181 cgccggcatt tcccctgaac ctccctgcgc aggctcatcc gtttgcggct tcagggcgtc 3342241 cgctccatca tgaaaggcta catttacaaa gctgatgaac ccgttatgtt tccgaaattc 3342301 atctacgagc tttttcgcgt tcgggacaac ctggccgctt tgatcaatcg gcacaattcc 3342361 cttttgtaaa tcaatgataa ccaatgctgt tttttgaaaa tcaatgttga gtgtattcat 3342421 catacgtctc ctcctgatac tgttagtgtt tctcacattg catattttac tcttcacact 3342481 gcctaagttc ttttatgatg cttgtgaaat tctcagaagg agcgttttct catgattttt 3342541 cttttatgta gtagtaacag gttgtgcata cgaacaaacc ggcaagcact gtaatcataa 3342601 agggcgtcat cgcttcatca cctgcctgct gtctatcggt tcctgcctga aaatgcccat 3342661 gaatttgcgg cggtccatcc aaagcaggat aagacacata accattaata tcgtgctaag 3342721 atcctgcacg ccaatatcaa aacaatagtt aatcaagacg atgttcacaa taatgggcat 3342781 aaaaataacc gcccctaatg cagccgttcg cggaatcagt aataaaacag ctgccaggat 3342841 ttcaccaaaa cctataaaca gttcatagac atgagaataa ccgaaaaatg tccacgcgat 3342901 cgtaaacccc ttcccggcag ccgcctcgat ttcaggcgtc acctcgccaa actggccaat 3342961 taccactttc gccagaccgt acacgaaaaa attaaaggct aaaaacaatc ggaacgtcgc 3343021 gggaatcgac ttgcgtaccg ctttcctcag cctgccgcct ttattcatca tacatccccc 3343081 tcagtgtatt atttgatgta gtacacttaa tacagtatag agtattctaa ttaatgtcaa 3343141 ttcccttttc agctcatatg aatagtttct tttatagata caaagtctta tatcgcaaaa 3343201 aatgccattc tccttccttt ccatccctcg ataacatttc tcaaaaacca tgtcaggaaa 3343261 tcttacatga aaatgtttta tcattctttt ttctctataa tgaagaaata taataattgc 3343321 tttttattct gaaagatacg gaggaatgag acatgcaaat gggcgataca gtttttatgt 3343381 tcttttgcgc tttactcgtg tggctgatga ccccgggatt agcgttattt tatggaggaa 3343441 tggtaaagag caaaaatgtg ctgagcactg ccatgcacag tttctcttcc attgccatcg 3343501 tttccatcgt ttgggtgctg ttcggatata cacttgcctt cgcaccaggc aattcaatca 3343561 tcggcgggct ggagtgggca ggcctcaaag gggtcggatt tgatccggga gattacagcg 3343621 ataccatccc ccactcgtta tttatgatgt tccaaatgac gttcgccgtt ctgactacag 3343681 cgattatttc cggggctttc gcagagcgga tgcgattcgg cgcttttctt ttattctcgg 3343741 ttttatgggc ctctttggtt tacacacccg tagcgcactg ggtatggggc ggcggctgga 3343801 tcggccagct tggagcgctc gatttcgctg gcggcaatgt tgttcatatt tcctccgggg 3343861 tggcaggact tgttcttgcc attgtgctcg gcaaacggaa agacggtaca gcgtcttctc 3343921 cgcataacct catttacacc ttcttaggag gagctttgat ttggttcggc tggttcggct 3343981 ttaacgtcgg cagcgcattg accttagatg gtgtggccat gtacgcgttc atcaacacaa 3344041 acaccgcggc tgcagccggg atcgccggct ggatcttagt agaatggatc attaacaaaa 3344101 aaccgacaat gctcggagcg gtatctgggg caatcgccgg gcttgtcgcc attacgccgg 3344161 ctgccggatt tgtcacaccg ttcgcttcca ttattatcgg catcatcggc ggagctgttt 3344221 gtttctgggg agtattctcg cttaaaaaga aattcggata cgacgacgcg cttgacgcct 3344281 ttggcctgca cgggatcggc ggcacatggg gcggaatcgc aacaggatta ttcgcaacaa 3344341 cctctgttaa ctcagcgggc gcagatgggt tattttacgg tgatgcaagc ttaatctgga 3344401 aacaaatcgt cgccatcgcc gccacttatg tttttgtatt tattgtcact ttcgttatta 3344461 ttaaaattgt aagcctcttc cttccccttc gcgcaactga agaagaagag tcacttgggc 3344521 ttgacttaac gatgcacggg gaaaaagcat atcaagattc tatgtgagga gtgacgctat 3344581 gagcggtcaa atgttcaagg tagaaattgt aacgcgtccg gcaaattttg aaaagctgaa 3344641 gcaggaactc ggaaaaatcg gagtgacctc tctgactttc tccaatgtac acggctgcgg 3344701 ccttcaaaaa gcacatacgg agctctatcg aggggtaaaa atagaaagca atgtatacga 3344761 gcgtttaaaa atagaaattg tggtcagcaa ggttcctgtt gatcaagtga cagagaccgc 3344821 taaaagggtg ctgaaaacgg gatcaccagg tgacggtaaa atatttgtct atgaaatcag 3344881 caatacgatc aacatccgca caggcgaaga aggacctgaa gcactttaat atcggtacga 3344941 gattcggaca ctccggatct ctttttttgt gcacagaatc cccccagaaa ccgcgattcc 3345001 tcttcgaatt ctcttcaagc gccgttattt cagacaatct ctatttttat ttgaaacttt 3345061 tcatgagtaa gattagtcta ctaaatataa aaatgtaaaa ggtgattatt tgaactacga 3345121 aatttttaaa gcaatccatg gactatctca tcacaattca gttctcgatt ccattatggt 3345181 cttcatcacg gaatatgcca ttgtcgccta tgcccttatc ctattggcaa tctggctgtt 3345241 tgggaacaca caaagcagaa aacatgtgct atacgcaggc atcacaggaa ttgcaggcct 3345301 tgtgatcaac tatttgatta cgcttgttta tttcgaaccg cgcccgttcg ttgcgcatac 3345361 agtgcataca ctgattccgc atgctgcgga tgcttcattt ccaagtgacc atacgacagg 3345421 tgcattagcg atttctattg cgatgctttt cagaaaccgc aaaatcggct ggccgcttgt 3345481 catttttggg cttttgacag gcttttcgag aatttgggtg ggacatcact atccggtaga 3345541 tgtattgggc agcctcgttg tcgccatcat tatcgggttc cttttcttta gattttcaga 3345601 tctgcttcgc ccgttcgtcg atttggtcgt gaggatctac gaagccatta tcaataaact 3345661 gacgaaaaaa ccaaccgatc aaaatttcta agaaagacaa aagccggcgt ctgaaatcaa 3345721 gacagccggc tttaatattt ctcatacatc tcttgttttc ttcgcttcgc caacacatat 3345781 aaaccataaa acaacccaat tccaacagca tcgatgagca catcccggat acaaccattc 3345841 ctgctgaaga agagctgaag aacttctgtg aaaaaagcaa acgcaaatga gccggctgca 3345901 gctgatctta tgctgccccg ctgtttccac agcaaatatg tcagcacaaa gaaggaaaac 3345961 gcgtgtccga ttttttgaat aaacgcttca ggtacagtaa gctcagtaaa atccataact 3346021 aaaaattgag acagatcagg gtgcggctga aaatgaaaag ccaccgtttg cgatacgacc 3346081 atgccgctga agctttccgt acagacagaa agcaggataa aaaagatcca gcctgcgagc 3346141 aataggcggt tcatgacata acctccttta taacgtacgt gcctacatgt aactacatag 3346201 acggtaaaac aaagcaaaaa gtaacagaaa aaaacgccca tcacaaggat agacgttttc 3346261 ttcattaaga ctgttcagtg tcttctgttg tgctgctttc tttagaacca gatttgtcag 3346321 ttgaatcatc ctttttctca ccggattttt cttctgttcc tttttcagtt gatccgtcct 3346381 ttttctcgga agattgctga atggattctt ctgtttcttg ggtggcagct ttttcaatag 3346441 aagaaactgg tttgtccata aagtttaacg gattcattgc aaccccatct ttacggattt 3346501 caaagtgcac gtggtttccg ctgtcttcac tgtaaaggtt cttgccagat tttccgatca 3346561 cttgattttg ttttactttg tcaccttgct ctacgcttac ttcggaaaga gattgataca 3346621 cagtcgataa accgtcggca tgttctactt ccacaacata tcccagcact ggatcttttt 3346681 cagctttaac aaccgtaccg ctcagagaag cagagacatc gaaatctttt ccgtctttct 3346741 cagctaagtc aattcctttg cttaggctgt acgtgttatt ataggtaacg agtgctgctt 3346801 ctttctcttc ttttgcggca tcggtttcat agaacttttt cacaacagaa acgttttcag 3346861 aatcaacaac cggcattgcg acattttcca ttgactttcc tacttcaact gcatcgtcgt 3346921 tgttgtcata tgcggagttt ccgccgttat cagccaactg atcctttacc tcatcatttg 3346981 atactgattg ataccaaagg acagctgtta aaatgacggc cgcactgact aagtaaattg 3347041 cagggaacac ccagcgttta cgaaaaaact gctgaagttt tttgacttga gaagttttct 3347101 tttcttcctc tctcattgtt tcatcacctc agcaacattc tgaacacttt tctgaaaata 3347161 tatacaacct atccaaaaaa acttttttag atgtagtttg cacagactga acgaaaatat 3347221 gtattttttt gagaggagtg ccaaaaacgt atgaacatga cattgcgtct tgctgaacat 3347281 agagacttgg aggctgttgt ggcgatttat aattcaacga ttgcttctcg aatggtaaca 3347341 gccgataccg aaccggtaac tcctgaagac cggatggaat ggttttcggg acatacagag 3347401 tcacgtccgc tctatgtggc cgaggatgaa aacggaaacg tcgctgcctg gatcagcttt 3347461 gaaacatttt atggaaggcc agcctataat aaaacagcgg aagtcagcat atacattgac 3347521 gaagcatgcc gcggcaaagg tgttggatca tatttgcttc aagaagcgct ccgcattgcc 3347581 ccgaatcttg gcatccgctc acttatggcc ttcattttcg ggcataataa accaagcctg 3347641 aagctgtttg aaaagcacgg gtttgcagaa tggggactat tccccggcat cgccgaaatg 3347701 gacgggaaaa gatacgattt aaaaatttta gggagagagc tttcatgatt agtctggata 3347761 aagatgaaaa cgaaattgaa catcataatg aagaaaatag ccttgttgaa caggagactg 3347821 cacctgttgg acaggagagc cgccagctga gcgcctccgc tgtcaagtcg ctatccgaca 3347881 ttgccaagtg gggcaaaatt tctggcatct tgttaatcat tatgggatcg cttgtcactc 3347941 tgtctgtttt gatgacagtg attggcgcca tcccgggcgt actgctcatt atttcaggcg 3348001 tatttttgat gcgctcagca aaagcagccg cggaagccga aggaaatcta accggcagcg 3348061 ctggcgaaag catgcttgaa aattacggga catttataaa aatgcagctg ttttatgcag 3348121 catccagtat cgttactgtc ctgatcggga tcattgtagc cattttcgtg ctggtggtaa 3348181 tcggcattgc tgcttttgag aacacgcctt cgtatgatga tccggattct tattattatg 3348241 aggatgatcc ggtgtttgaa taatgatgag acaggacagg gcatgagttc catataaacg 3348301 gaaccatgcc tattttattt gactattcaa agcaggccgg cgtaaacacc aaatcctgaa 3348361 gcaagcatac aatagacatc tctagtagag gaaatcaaca aagcaacgct gttacccaga 3348421 aatgaatatc aaaaaaacgg atgaagtcgg aatcaatccg aaaccgcact ttttatttcg 3348481 ggtgtctgca tgcaaaaaaa cacacccgga tcgtctggaa aatctcaaca atccgggtgc 3348541 agatcttctt taatacattt ttttgcgtct gtcttcctca gtcaaaaatt caacaaaact 3348601 ccgcatcgca aaaggctctt cctttatttg tcgtgcgtag gagcttttcc gctcttctga 3348661 aaggatttcg ctctttttga tcctgttcag catatagatg tgaaccgttt tttggatttg 3348721 tttatgctga tagcctgcct ctttaaaaaa tgcgagcccg agcgccgcca aaagggcgaa 3348781 tatgcctgcg ctgatcaggg actccctgtc agctgaagca tgaaatagaa aagcagctaa 3348841 attaaagaga gagaatgcag caagcggaat agcaagaaaa cggtaaatga cggttttttt 3348901 catgaaaggc tgtacggcct tttgaatttt ttgcatttct gttttgatga accccggcat 3348961 ttgttcgact ctgtaaaagt tcatataatc ctcccccttt atttgatgtt tcaagcttca 3349021 cgaacgttat catatgtgtt tattttaacg caggtgcaag ctggttttaa agaaatctgc 3349081 ccgtattttt cacgaagaat ctggatcgcc gctctttatt cttttaaaat gtgagtgtta 3349141 taatttgtaa tgggaatcag atcactgtta ttcatggaat actaatggca atcttcttga 3349201 taaatatgaa tgagcggggt tacaaagtga gtatttcttc catcctttta tcactttttt 3349261 tcattttaaa tattcttttg gccatcattg tcatcttcaa agaacggcgc gatgccagtg 3349321 catcttgggc gtggctgctt gttcttttct ttattcccgt tttaggcttt attttatact 3349381 tattattcgg ccataatctc agacgcaagc atttgtttca atgggaagac cggaaaaaga 3349441 ttggaattga aaggctgctg aagcatcagc ttgaagattt agaaaccaag caatttcagt 3349501 ttaacaaccg ggcaaccttt gataacaaag atttaattta tatgctgatt atgaataacc 3349561 atgctgtgtt tacagaggat aattcagttg acgtcattac agatggacgg gataaatttc 3349621 agcggctgct gagtgacatt tcaaaggcta aggatcatat ccatttacag tattatattt 3349681 ataaaggcga tgaattaggc aaaaaattgc gggacgctct catccaaaag gcgaaagaag 3349741 gtgttcaggt cagagtgctt tatgatgaac tcgggtccag aacgctgaga aaaaagtttt 3349801 ttaaagagct tcgcgaggct ggcgggcatg tggaggtctt tttcccgtca aagctcaggc 3349861 cgattaacct gcggctgaat taccggaacc atcgaaagct tgtgatcata gacggtatga 3349921 ccggttatgt cggaggcttt aacgtcggag atgagtatct agggcttaat ccgaaattcg 3349981 gttattggcg ggatacgcat atccggctgc aaggaacggc cgtgcacgcc atccaaacac 3350041 gattcatcct tgactggaac caagcttctc atcaccatac gctgacatat attccaaatc 3350101 actttcctga ttacggccca aaaggcaacg tcgggatgca gattgtcaca agcggccctg 3350161 attcggaatg ggaacaaatt aaaaatggct acatcaaaat gatttcgaac gccaagcgtt 3350221 ccattttgat acaaacacct tattttatcc cagatgcaag cctgctggat gctttaagga 3350281 tcgcttgcct ttcgggcatt gacgttaaca ttatgattcc gaacaagccc gatcacgcct 3350341 ttgtatactg ggcgacactt tcgtatatcg gcgatctgct gaaagccgga gccactgtct 3350401 atatttacga taacggcttt attcacgcga aaaccatcgt ggtggatgac gaaatcgctt 3350461 cagtcggcac agcgaacatt gatgtccgaa gcttcaggct gaattttgag gttaatgcat 3350521 ttatttacga tatcaccatt gctaaaaaac tggtttcaac ttttaaagaa gatttgctag 3350581 tatccagaaa attcacctat gaggagtatc tgcagcgccc gttgtggatt cgaataaaag 3350641 aatccgtctc gcggctgttg tcgccgatct tataagatgc gtaaaccccc ggcctttacg 3350701 gccgggggtt ttcctgatgg tcacagtaaa tgatgattgc ctcccgcaaa aaagcggcaa 3350761 gaccttctcc atattgattg attgaatcgg taaatcgctc gtcagtgata tacacttccc 3350821 cgagtcctct gaaaatgtcg agtgtgcaat cgtaatgata ttggcaaata tgatcgcgaa 3350881 atgcccccac agcggcctga atctctgcat catcgggccc atgcttcatt cgcgccgcaa 3350941 ttcgtctgta aatcgaatca aattcagcca tgatcgtgcg ccaatcatct gccgagtatg 3351001 cagatgtcct tttctctgtt tcttctgcga tttcctttcc atacagcttt ctgacttcat 3351061 cagcgtatgt ctgctggtgc tcttcaatgt ctttcatgct taatccggca aataaatccc 3351121 tcttattcat cgtttcccct ccatcaacgg acaaaagcgt cctgtcaatt gtttgaatca 3351181 tctcatccat tctttgtttt ttcttcatca atatctcctt ttgcgactga agtgccgctt 3351241 tccggtcaaa attcggatga tccagcatct ctttaatctc atccagacga aacccgattt 3351301 ccttgaaaaa taaaatctgt tgcagtcttt ccaggtctgc gtcactgtac aaacgatacc 3351361 cagcatcagt aagcgctgaa ggattcagaa gctcaatatt gtcatagtga tgaagcgtcc 3351421 gaatgctaac gcctgatatc tccgccactt gtttaacttg atatttcata cataacacct 3351481 cctctttttt atcgtaaaca atcacgcaac gttagggtca atccccaaaa tgttattttc 3351541 tatatacaaa acttctcaca aatagtgtat aaaagaaaag tgagtatttt tttgtaaagg 3351601 ggagccagta tacatgaatc ctgaaacaat gaacaaaacc ctcatcagca tttcgaaatg 3351661 gggaaaagct acaggcattt tatttattat tatgggcgca attaccgcgc tttcaggcgc 3351721 gttctttttt ctaatcggtg ccgtgccagg cgtactgcaa attatttccg gtatcttttt 3351781 gatgaggtca gctagggaag caggccaaat ggctgaacac aatagcggac agtctgaaga 3351841 cttaatgctg gagaattacg cgaaattcgt aaagatgcaa gggatttatt tgatcgtaag 3351901 cattgctgta tccattcttg cgattatcgc cttcttcatc tttttaatgc ttgggattgc 3351961 tgacggcctt ttcagcgata cgtacagcac ttattaatga gaaaaacccg gagctggctc 3352021 cgggtttttt attattccgc ttcgcttacc actgtgaagc gttcattttt gtgttcggga 3352081 tgttcaagct cgtccaacac ggcaatggca taatctgcat agctgatata gctgtctcct 3352141 tttgcattta cgatgacatt gtcttttcct ttttggtaag agccagtccg ttttcctgct 3352201 ggatcaaaaa atgccgcagg actgaggaac gtccaggaaa tggagtctgt ctgctgcaaa 3352261 tctttcaggt tctcgccttg atttgatgca gttggcaaat attctttcgg aaattccggc 3352321 gtatccatta aacgggttgt tttggcttca tcaacaaaca ggcttcccgc tccgccaaca 3352381 acaagcaatc ttgtgtgctt cgcgtccttt aaaatgctga tgagtgctct tcctgcttca 3352441 acatgaagat gttcttggcc gggtgctgct ccaaaagcgt ttacgaccgc gtcgaaaggc 3352501 ttgatgtctt ccgcagtcag ttcaaacaca tctttttcca aaatcgctac gtcttgctcc 3352561 tgcacttttg aagcgtttct gacgatggct gtcacttcat ggcctctttt tttcgcttct 3352621 ttcaaaatct cgtttcccgc tttcccgctt gcgcctataa taccaatttt catttttcat 3352681 ttcctcctta tttgtaacaa ttttagttac atgttagcgg tgagaagtca tcccttttga 3352741 ttaaaagaga tgattcataa catcttttaa tgacttgctt gccagttcat tttccatcgc 3352801 tctttgcaca ctttcaaacg tttcatccag agcgttctga atttttttcc ctaccggaca 3352861 tttcggattc gggttttcat gaaccgcaaa gagttcttct tgcttttgga cagcccggta 3352921 cacttctaaa agagaaatat cagcaggatc ttttttgagg cttgcacccg gcaccccggc 3352981 gcgtgatgtg agaatatcag cttttttcag caggctgatc attcttcgca caactaccgg 3353041 attcgtgttg acactgtctg caatgatttc tgaagatgtt ttttcatcca tcgagatgag 3353101 ggataaaata tgaatggcaa cagcaagacg gctgttaatc atgttttttc accaccgttg 3353161 taactataat agttacattt gattcgtttg tcaacatcta atatacacta aatacatggg 3353221 ttttgtgcac cgtttttagt caatagaacg gccggatgca ctccggccgc gtcttatcaa 3353281 aataagaaat atctttgtcc aagtgggaca taatcgacag gctggcaaga caattcctcc 3353341 ccgtcagcaa agacctgata ggtttttgga tcaatctcaa tcttcggcaa agccgaattc 3353401 agcttcatat ccagcttgct cagctttctg atatttttga ctggagaaat ccttttttcc 3353461 agccctaagc tttccgccac accacgctct atgcttgcct gagacataaa tgtaatcgag 3353521 gttgagcggt tggcttttcc gtaagacgca tacatttggc gcatgaaaac cggttcagga 3353581 gtcgggatgg acgcgttcgg atctcccatt tgcgcacgtg caatcatgcc gccctttaag 3353641 accagttccg gtttcacgcc gaaaaatacc gggtcccaca gaacgagatc agcaagcttc 3353701 cctttttcca ccgagccgac ctcatggctg agcccgtgcg taattgccgg attaatcgtg 3353761 tatttggcaa tgtaccgttt tgcgcgcaca ttgtcattcc cgttttcacc ggcaagagcg 3353821 ccgcgctgtt ttttcatttt atcggctacc tgccatgttc ggatgatcac ttcaccgacc 3353881 cgccccatcg cttgggaatc cgatgatgtc atgctgatcg cacctatatc atggagaata 3353941 tcctccgcgg caatcgtcgc cgccctgatt ctggaatggc tgaatgccac atcttcaggc 3354001 actttcgcat ctaaatggtg gcagaccatc atcatgtcaa gatgctcatc catcgtatta 3354061 acggtataag gaatggttgg cgttgtagat gacggcagaa tgttcgcgta agaggcgagc 3354121 ttcataatat ccggagcgtg accgccgcct gccccttcaa tgtgataagt atgaataacc 3354181 cggtccccga tcgcgtcgag cgtgttttcc aaaaagcccg cttcgttaat cgtatcggta 3354241 tggatggcaa cttgaatatc agcctcgtcc acgacttcca tacacgtttt aatggcgctt 3354301 ggcgtcgttc cccagtcttc atggagctta agaccgatgg cgcctgcttc cacctgctcg 3354361 atcagcggcg ctttatcgga tgcattccct tttcctaaga agccgacatt gatcggaaac 3354421 tcctcggccg cttccagcat cctcgccata taccacgccc cggacgtaca tgttgtcgct 3354481 ttgcttcctg tagcgggtcc tgttccgcct cccaaaaggg tcgtcacacc tgaagaaagc 3354541 gcaacttcca tctgctgagg acaaataaaa tgaatgtgcg tgtccactcc cccggctgtt 3354601 aaaattttgc cttcaccgga aatcacctct gtccccgctc cgatgaccat gtgcggatcg 3354661 actccatcca tgatatcagg atttccgctt tttccgacac cgacaatccg gccgtctttc 3354721 acaccgacat ccgctttgac aatgcctgtg taatccaata gcacgacgtt ggtgataacc 3354781 aaatccaaag cgccgtcctt ccctgtgatt ctgccgtttt ggcccatgcc gtctcggata 3354841 gtttttccgc cgccaaagat catttcttca ccgtatactg tgaaatcctt ttcgacttcg 3354901 atccataaat ccgtgtcgcc caatctgatt ttatcgcccg ttgtcgggcc aaacagttcc 3354961 gcatattcct cccgtgacat tttcatcgga ttacaccctc catccagccg gcttgtttta 3355021 agttggccaa cgttttttct ttgccgcgtt catcgataaa cgtgtcggcc attccgttca 3355081 gccctctaat tgtcttgcgt cctctgattt ccactagtga gaccgttttc tgctctcccg 3355141 gctcaaaacg gaccgacgtg cctgatggaa catcaagacg catgccgatc gccagctcac 3355201 ggtcaaataa taaagccccg ttggcctccg caaaatgaaa atgcgaaccg acttgaatgg 3355261 agcgtgatcc ggtgtttttt accgttacct cccgtatctc acggccttca ttaatcgtaa 3355321 tggttccctc agcaatttga aatgctcccg gcttcatgac ttcacctccg cagaaattgg 3355381 ctgatgtacc gtaacaagct ttacaccatc cggaaatgtg gcctccacct gaatgctgtc 3355441 cagcatctca ggcacaccct ccatcacatc tttttccgtt aatacatggc ggccggcttc 3355501 catcagctct gctactccct tcccatcacg tgcgccttcc ataataaagc aggtgatata 3355561 agcagcagcc tcaggatagt tcagcagaac gccccgcgcc tttcgctgtt tggctaattc 3355621 ccccgctgca aaaatgagca atttctcttg ttcaactggt gtcagtttca tctgtagtcc 3355681 tccttctttt gtcatataaa gcagatgcgg ctactacgaa tttgcggaac agtcaggcgg 3355741 gacatcacct ccctttcttc gagaatgggg gtcatacggt aagatgcctt tcaaagcggc 3355801 atgccgtttc ttcatcagcc ttgccatggt caacaaccgt tcccctgtcg atcacggaaa 3355861 gatcagatta acgcgttttc cagactgcgc tcgactaaga taacaaatgt ctttttttct 3355921 ggaaatttct ataataactt gtctgactag ttcgacaatt aaaatctgaa ttccttccaa 3355981 ttgtttatta agtaaaatat ttttcagatt taccatcagc gctctggtga ttgcaagctg 3356041 ctgctgttga ccgccttttc gttttgaaca aacgtttgat taaaacaaat agccccctct 3356101 gtttagccgg agtcggccta atacagcgac aatctgcccc gggcgaagct aaggctgtgc 3356161 aaaaccatcg attgatcata accagacgtt acattcctga tggcagcccg ttgttttgct 3356221 ccgcaaccgg aagcatggca tggaggccag tctgaggcgc cgacctccac gataccgaga 3356281 acccgactat tgccattaac tccgcatcat ggacggtcac ttcgctgatc gccaccgttc 3356341 ctcttaatga gtgaagaatt ccggccttca ctgaatcccc gcttgtgtcg atatcaactg 3356401 ttttctcgca ctcccgtggc ttccgacact ttcttcggtg cagtacattc cgtcatcaaa 3356461 acccctttgt ttgatttctt caaatgatgt tataaaagtt tacaacttat gtcatcatta 3356521 tatagaagag gcctattaat tcaaagaata tttaaaaaat ttagttacct tgaccaaatc 3356581 agcttctttt tttgttatat ttattcacat cagaaaaagc gaaaaaaaaa gacaagaaac 3356641 atttcgtttc ctgcctcttc cgtacgatta atctttatct gaaaatttat ccttggcttt 3356701 cccgatatcc ttttggattt cgccttttgc cttatctttt ttgccttcag cctgcatgtc 3356761 cgttctgtca gccatatctc cgactttatc cttcacttct cctttggctt tattgaagcc 3356821 gcccttcatt ttgtctttta cactatcgtt acccatgtta attctcccct ctcaattatg 3356881 tgtgtacttg ttaacttccc gatctgagag gcaataaaca ttctaatgtt atttatcgat 3356941 ttcgtagcgc tctccgtaac ggagcacctt gtatatcgcc agcccgtctg atgacttttt 3357001 ctccgaatat cggaccggca gcagggcaaa aaacacataa tacgtagaaa aatagacaaa 3357061 ctgatagaaa aacacattcg gctttaatac actgtgtata atcagcagat tgattgcaaa 3357121 aatcgtgatg aggttaaaca agcagccccc tgcatacacg agtgcatttg agaatcgatt 3357181 gtcaattttc aactccccgt accggcaaaa agaatcgata aaataaatcg ttctgaaccg 3357241 tatgggtcca attttaagca gcgtttttcc catgcctata tccaacgatc cctttccgcc 3357301 aaaaataaaa gccataaagc tgtgccctga aacatgtata atctgtacaa gcggcagaac 3357361 aatgaggaaa gaccacagaa acttcaccat atcattaaaa ccaaacattg aattccccct 3357421 cacatgcata tctgcatccc aaaacggctt ttgttcaaaa aacagtgctg tagcgatttt 3357481 tcctgttctc cccggaaata aacgttccga tgctcccctt tttttgcata aaaaaaaacc 3357541 atctgccagc agatggtttt gtctcatact tcatataaac aatcgttcct ttgaatcatc 3357601 tctctcatgc tgaccgcttt ttcataaaaa tacaccgctt ctttatattg ttcgcgatga 3357661 ctgaaataag aggcagcatc taaagcaaat tcttcaatat atacatacag gcccttttct 3357721 tccatataat caaatacttc ttgaatcata ttcaaattga cagattccac atataatgcc 3357781 tgcagaaatt tatattttgc cagactgaag aagtcgtttc gtttttgggc aatggcaatc 3357841 cctttttcat agtaccgtat cgcggcttcg ctatcttgtt ttttgaaaag aacgcgagtc 3357901 aggctgaaga gcgcttttgg aagctgttcc agctgataat cctcgaagac aggaagcgct 3357961 ttttcaaagt attcggcggc ctgatccagc tcccccttgt catcatagca attaccaata 3358021 ttataaaggg ctgatccgat caaacggggc tgtccttcca ataaagcaag gcgatacgcg 3358081 tcatctaaat gttcaagcgc tttttcataa tttctgtagt caatgtagtt tcctgatatg 3358141 acgaaatggc attgaattct tctgactctg taaaaatcgt gagccttata cgtctccagc 3358201 gcctgtacgg catggttcat ggaaaagtgc gtctgcttca taatataaaa gacttccgcc 3358261 actttaaaat gaaattccgc tctttcaatt tcatcttcta caaacgcaag catcttctca 3358321 gctttccgat aaaaggatat agccgagatg taattgttct gttcaaattc gtacattcct 3358381 ctaaacaagt gaaaataata ctcagataat ccggagatgc tgtcctgatt gctttccagc 3358441 gttttgatca attcacgata ttgaagctga gattcctcgt gcaggtcagg ctttacataa 3358501 tccagcataa tttggtgccg gtagctgatc agctgataat acaggagaag cagctgatcc 3358561 tcttccatct gttcgatatc tagatcaatt tcttctttca gttttacggc atcagccact 3358621 tgaaatgcta aaatgtgctt ataccactta ttgattttca ctcctacttg agatgacggg 3358681 atctcgtacg cggccatgcc cctccaaccc tttctatttt ctaattggtt atattttatc 3358741 ataatgtatg gctttggaat taaattttct tacaatgatt ccttctttat gcctatcctt 3358801 atatatttcg gtttttctac gtattttttg cactcggatt ctaataaaaa agcttaccgg 3358861 acagtgccga taagcttttg acttcaaatt aaccgccaat ataagacatt tccactttct 3358921 ttttgccaga tgcttttgat agcgtacgat cgactgaata ctgatcgatc cgatttttcc 3358981 atactgtccc gatcatttct gatagttcgt catcacttaa ttcctggcga accggagctc 3359041 tgaggtcaaa tccgcttgaa gcgaataagc aggtaaacag ctctcctctc gcagaaagac 3359101 gggctctgtt gcaagatccg cagaatgcat cagatacaga tgatatgacg ccaatttctc 3359161 cggagccgtc caagtagcgg aatctggaag ccacttcgcc tatataatta ggcgctatcg 3359221 gctcaaccgg catgtgttta ttgatcaaat ctatgatttc cgcctttgtc atgacgtctt 3359281 tcttttccca ttggttggtg ttgcctacgt ccataaattc aatgaatctc aggatatgcc 3359341 ctttttcttt aaaataacgg gccataggca gtatatcttt ttcattgacg cccttttgaa 3359401 cgaccatatt gattttaaca ccgagccccg cttgcttcgc cgcttcaatg ccttccagca 3359461 ccttgctgac agaaacaccg cgcccgttta tcttcttaaa acgctcgtct tctaaagaat 3359521 caaggctgat cgtaaccctt ttcagcccag cctccttgag cctcttagca taaacaggca 3359581 gcagtgatcc gtttgtcgtc atcgcgatgt cacgaatacc cggtatgcgg gccagttttt 3359641 tgattaattc cggcatatcc tttctcatga ggggctctcc gccggtcaag cggatttttt 3359701 caacgccaaa tcttgtgaca aacaatgtcg caagccgttc cagctcctca aatgaaagca 3359761 gctcctcttt ctttaaaaaa ggataatccg ggccgaataa ttcggcgggc atacagtacg 3359821 tgcatcggaa gttgcagcgg tctgtaacag aaatgcgaag gtctctcagc ggtctgtttc 3359881 ttttatccaa catctgacgc gactctgtaa tcatagctac agccccttcc tactccctga 3359941 ttctctcagg gtgtgtatat acattaaatg atccgtttct gacaaatcca atcgctgtga 3360001 tattcaattc ttcagccatt tgaatcgcaa gctccgtcgg ggccgatttg gaaatgacaa 3360061 tcgacacgcc gattttggcc gcttttaaca ggacctctga tgagattctg ccgctgaaca 3360121 caatcagttt gtcgcgtacg gacatcccgt ttagaaggca gtgtccgtat agtttatcaa 3360181 gtgcgttgtg ccgaccgata tctgtgcgca tcaacagaag cttctctgtg tcgcaaagcg 3360241 ccgcattatg gacgcctccc gtatcctgaa acgtcccgct cccttgctgc atgtctttca 3360301 taagcgccag acatgcctca ggcgatatct tgatttggct gacagccgtc ttggctgttt 3360361 tgacatcctg ctgaaaataa aaatgacggc cctttccgca gcatgagccg atcacccgtt 3360421 tcgtataatc cttttgatcc aatgtctcag ggtgaacgag gtcgacatat acaaaaccga 3360481 gactttcatc tattgtaaac cttttaattt ctttttgaaa tcgtataaca ccctctgatg 3360541 cgagaaatcc gatgacaagc tcttcgatat gctcaggcgt acaaacgagc gtcacaaatt 3360601 cactgccatt cagtatcact gtcaaaggga attccgtcac catccggtct tctactttgc 3360661 ttatttcccc ttgttcatag cgccatacat ccctgaccgc agttacttta tcgttcaatg 3360721 tctcttcccc tccgcaatgt tcctgccttt atattttttc acactcctcg gattttgtcg 3360781 aattctgaga cacaaaaaga gccctctata taaagggctt ttacaggatg tgatgacggc 3360841 ggtgtttagg caggacgcct aagcatttag ccgccgttcc ttttataaca cgtgagcacc 3360901 aatgtgcatt gacaacgaac gcggggtttg tcgacacgct gagacacctc tgtataaagg 3360961 actctatgtt tgattatgct gattcttttt cagaaccgta aacagcacaa tagctgcgat 3361021 caaggtgaga atgctgacaa aaaagaaggc tgccagtttt agaagaacac caagcaatat 3361081 aaatgcaacg gtggctataa gaaaaatcat tccgaataat ttcatatgtt caaccccttt 3361141 ttagggtatc attcccgccc aaactgtttt taaaccaata aaaaaggcgc ctgggggagc 3361201 gcctgatctt taggttcctt actcagtaaa tttttgtgct tctttttccc aagcctgttc 3361261 gaactcatcc gcactgttcg ctgaaatata ttctccgccg ccagcgacag ctgcttgttt 3361321 catctcttca ttacccttga catcaaagtt gaagccaatg atgtttacaa tcgtatccac 3361381 atttgatgca cggagctttt cgatttccgc cgcagggtct ccgccgcacg tttcttcacc 3361441 gtcagtgatt aaatacacca cgtttttccc gtctgcgtca aatgcttcaa attcttttct 3361501 tgtgtctgca agtgctttgg caatcggtgt ccatccagtc ggcttgagct cactcaatga 3361561 attgtcaaac agagaccctt catatggatg aaggccgtaa atggtttccg tcgtactgca 3361621 cgaaagggct ttaccggaca gtttattgtt ccctgcatgc ccgaaaacgc gaagcataag 3361681 atttgtatcc tttggaagaa gttcggcaaa agattttact gattttttgg caatgtctat 3361741 tttgcgctct cctcctgttt tttgaaccat gcttccgctt ccgtcaaaca aaacagctac 3361801 atttgtatca gcctgtttct cagcggcaaa agacggggag gcaatggaaa cagtcaacaa 3361861 tccaatgata ccggcagcca gcaatttttt catatgatta cttcctttct ttttcatatt 3361921 ttccaactat atgttggatt cttctttatg ctagaatacg aaaatgcaaa aagatatagg 3361981 acatgctgcc ttttgtgctg ctttcacgat ctgtccaaaa tcgcttgaaa tgccgttcat 3362041 ttttagccat ttccgcccag aaagcataaa cagcttgtgt gatcattcat tcttttttcg 3362101 ccttgattat gacagaaaaa cggaaatctg ctactatgct acaggcagac agctaattag 3362161 ttttgaagtt tttgttacat acaaaaagag gctgaccatc accagcctct tttttcttat 3362221 ttagataaca ttagtgattg ctgagtgaaa attttctcaa catctttttg ggtataagcc 3362281 gggaagtatt caccgccgcc tactttcgca attgcgttca gctggccttt gtatccctct 3362341 ttataatcaa agccgatcac attaacagtg atattgtctt tttgcagttc ctttgctgtt 3362401 ttaatcgggt ttcctccgca cgtttcctca ccgtctgtca acagatacac cactttttcc 3362461 ccttttgcat caagctggtc aaaagaagat ttcgcctcgt tcagcgcttt ggcaattggc 3362521 gtccagccag tcggcccaat tgtattgaga gaattgagga agctttgctc gttaaagctt 3362581 tggaagccgt atacgttgcg aatggcttca catgactgaa cttttccgga atttttattg 3362641 tttccttcag agccaaacac gctcattttc acctgagttc cttctggcaa tgagctcgca 3362701 aactttgaaa tttctttttt ggctgaatta aatttagata caccatctat tcttttcgcc 3362761 atacttccgc tggcatcaag caagaccgcc acgttcgccg gcgctttagc ctccgtttct 3362821 gtcttttcag ctgcaaaagc aggtgaagtt aatccaaaaa gcaatcctgt catcatgatc 3362881 agtgaaaatc ttttcttcat gttcgtaccc ctttaccaat ttgtttctgc gtgcagatgt 3362941 tcaacgctga acataatcta tcgtaatcaa caaaaaccga gaaataaata gggcgggctt 3363001 ccccattgct gttgtttact tttgcataga aacctatgtt tttattagtg atttccacct 3363061 aacgccccta tgaaaagaga agattgtccg cctttcggct ttcgttatat gagtctgtcg 3363121 aagtctgtcg acaaatgtgg atgactttac cacaatctca aagcctgaaa tcaggaaaaa 3363181 aggactgatc cttaaagacg gtcagaagct cctctaaacc gtttcagcta ctcttagata 3363241 aaagatattc aggaacagaa aaagacgccc aatgagcgtc tttttctact ttttcgccat 3363301 atatttattc aaaaacgcat ctgcctcaga aatttgtgtg ccttggtaat agtactttac 3363361 aatgtcatca accgttttgc cttctttggc cataaaattc gctccgtatt ggctcatccc 3363421 cacaccgtgg ccaaatcctc tcgtcgtgac tgtaattgtg tctccatttc gcttccattc 3363481 aaaatcggcg gagttgagac ccaacttttc acgtatgtct cttcctttca gcgtcttgcc 3363541 gttaatgacg gcagttgcga cctggtggcc cggtgtctcg ccggtaatct tccctactgc 3363601 gctagatcca tccagcttga cgccaagctt ttgctgaaat tctgccgctg taaaggtttt 3363661 cgttgcctta tatttcggag actttttatc ccatgggctt ttgacgcttt ttaaatatgg 3363721 gatagcactt gtccaataag cttctgcatt ctctgtgtag ccgttgcttg tggagaaaaa 3363781 ggatgcttca atcggctggt tgttgtacgt taagattttg ccttgcgtac tggctaccgc 3363841 atctgtgatt ttcttcagtt ttgtctcata gcttgtgccc cactgttttt tcagctccgc 3363901 tttgctttta tacacctgga acatctgtgt atcatccacc agtgagcctt taggagcttc 3363961 taccgctgaa tttgacacca tcagtctgac aataaatgtt ctggcggcaa gcgcctgggc 3364021 tttcagcgct tcaggtttaa aggttgccgg catttcggag gcgacgactc caatcacata 3364081 ctcttcaagc ggaatgtttt ctacggattg atttgcggtt cgatagacgg gaatagaaac 3364141 aggtgatgct ttcaatgttt ctgctccttt cgatgctggt ttcgtgctga ctgctgtctt 3364201 ttctgattct acgctggccc ccgcttcctt attatgctgg aatggtataa ccaagagtgt 3364261 gggaaccaag agaatcaatg cacatagtac ggatagtgtg attgcgaatt gtttcatatt 3364321 cagctgcctc ctgctcggga ttcgactcta gtctagtcta tgggcaggga caagctaata 3364381 tgactctcgt tttggacaga aactttattt gtcatttacg tattcttttt tgctattttg 3364441 cgcataatga tgataataca caaaaaataa aaaaccagta tgccagagtg acatactgat 3364501 tttcaagtaa gtttatgcat ttaagtcaga aacgacttct ttattctctt gctcagaagc 3364561 agactcatca tttacacgtt cgatgtctgc gcccagagcg gcaagcttct gatggaaatc 3364621 aacgtaaccg cggtctaagt gcttcaattc agtaacacgt gtgtgacctt cagccactaa 3364681 ccccgcaaga atcagcgctg cacctgcacg caaatcagtc gctgcaactt cagctccctg 3364741 aagctgtaca ggaccgttaa tgatgacaga acgtccttca atcttgatat caccattcat 3364801 acggcggaat tcttccgcat gcataaaacg gttttcaaaa acggtttctg taatcatgct 3364861 tgtgccgctt gcacgaagca gaagcgccat catttgtgac tgcatatcag tcgggaagcc 3364921 cgggtgaggc attgttttga tgtcaatcgg tttaagctct ttcgggccga tgacacgcag 3364981 accttcacct tcatccttaa ttgttacacc catctcttcc atttttgcaa ttaaagaggt 3365041 gaggtgctca ggaaccgctc cttttactaa tacgtttcct tcagtgattg cagcagcaac 3365101 cataaatgtg cccgcttcaa tacggtcagg aataatatgg tgttttacgc cgtgaagctt 3365161 ttcgactcct tcaattttga tggtgccggt gccagctccg cggatttttc cgcccatgcc 3365221 gttgatatag tttgctaaat caacgatttc gggttctttt gccacgtttt ccagcgttgt 3365281 tgttccttca gctagagcgg ctgccataat caggttctct gtagctccta cacttgggaa 3365341 gtccagataa atttttgcgc cttgcagtcg gccttttact tcagcttcaa tgaagccatt 3365401 accgactttg atttctgcgc ccattgcttc aaaacctttt aaatgctgat caatcggtct 3365461 ggaaccaatt gcgcatccgc ccggaagtgc aactcttgca tgacctgtac gcgcaagaag 3365521 cggccccatg acaagcacag acgcacgcat tttacgaaca tattcaaaag gtgcttcagt 3365581 ttgcaaagcg tatgaagcat ttacagtcac ttcattattt tcaaaatgca catctgctcc 3365641 taaatgacgc aacacttcgt taattgtata tacatcggag agcgtaggta catcacaaat 3365701 tacgcttttt tcttcacttg ctaataaaga tgcagcgata acaggtaaaa cggcattttt 3365761 agcgccttca actttgactg tgccgtttaa cttctgaccg ccgcggacga tgattttttc 3365821 caaggtattc ccctccgcgt ccctaaattc tctatattaa tattcagtcg taacgattgg 3365881 tgtgccaacc gtaacggtat gttttccgcc cattcctgca cttctaagtg caatttgcaa 3365941 attcatttta tgtttcgagg tcataatgta ctcttcccac tcatctgtaa acgcagaaat 3366001 agaaacgaaa tttggctcaa ctacatgttc tactgatctt gcttgaaatt catttaataa 3366061 ctgatttgct tttttttgca aaacaatatt catattatca tctaagtgac catttagaca 3366121 agtaaaaata actacttttt cttggaatat cccaagtgtc tcccgttcaa actgttcata 3366181 tgtatcattc cagctatccg gtgtctctag actcatttgc tcatataata aatacgaagt 3366241 tggattgtgt tttttgaggg ttgtgacaag ctgcagtcta aaagaagtac gatttttttt 3366301 gtcagtatat gtgccaattg cctttatcat tttatcttcc cgtgcaatca cccaatcata 3366361 ttgacgatac tcttgtttta aacgttgcac tttttgataa aattcttttt cggtcagtga 3366421 caagttttgt tttgcatgca atgtccactt atctattgac acatcttgac gttccatccc 3366481 ctctgccatc tgtgctaacg gcgttaattc actcgcatga atggtatgga aaacagcaat 3366541 gacgaagctt aacatgacgg aaatgataat agcgtggctt acttgttttt tcttcatgtt 3366601 catctctccc ccttatcccc agttttaccg gaggcaagag gcgccatacg taaaaatctt 3366661 cgtcaaaact cgagctattc gcttcaaccc gcttctccca accatttaat aatgttcaaa 3366721 acctattaaa atagataggg aagctgctgt gaataattga ggtaatctaa aaagaaattg 3366781 gcaacggccg ttccaatggc gattgtcagc aaaatcatca ggagtcttgc ctgcacgact 3366841 ttgccttttt tgattaacgg atctatattg acggcttgca acgcccacca agtcactgct 3366901 ataaaaatca ggtgaacgac aatgccgatt gcagcctgct gtcccaatac actcatctat 3366961 tacactcctt tctctgcgtt catacccttt cttattatat aagaagcaca gataaagatg 3367021 atacatttta tacagaacgg aataatcagc caaatctagg gctaatcccc gcttaaagtg 3367081 cgattctttt acatggtata ctttattgga aaggagctgg caaatgtgaa tcattctttt 3367141 tttcagcctg aaaagcaata tggtgaggac ctgccaattt ttgatcagga atgggaagca 3367201 attgcattct attatgatta tagacagtca cagattgaag aactgaatga attgtgtcag 3367261 ttttttaaca tttctcttac ctatacgaga gaaagccttg aagagcttga aaacctctat 3367321 tttcaaagta tacaagaact tttgcttgct gattggaatc ttcctattga agaattcgag 3367381 aaaatgatca gtgtttatct tatagattgt gtgattgccc gccatgaaga tgctgaatgg 3367441 gttgtaaaac cttatcccta taaagacggc gcttatacac ttggctttag aagacatcgc 3367501 aaatcgtggc atacaatgaa tgcctgtgat ggtttatacc tgcgtccaaa agaggatcgc 3367561 ccgttgctgt cgctgtttga ttctcttgtg cgttcataaa aaaatccttc tcataaagag 3367621 aaggattttt tcttatttcc ctgctacatc caatctgttc aaagcccgct gtaacgcaag 3367681 ctcagcccga cgaatgtcag tatcatctga ttgagaattc aaacgctcct gcgcccgctg 3367741 gcgtgcagct tcagcgcgct ctttatcgat gccttccgct gtctcggcag cctgggcaag 3367801 gatggtgaca tgatcaggac ggacttctac aaaaccgccg ctgacggcaa ccatttcagt 3367861 ctgcccgtct tttttcagac ggacagcgcc gattttaaga ggagccacgg ttggaatatg 3367921 gcctggcaaa ataccgagat cgccgctttc ggctctcaca ctcaccattt cgatatccgc 3367981 atcgtatact gggccgtcgg gagtaacgat attgacttta acggtcttca tgcttttacc 3368041 ctcctaggac cagattaaac ttctacaccc atttcttttg ctttctcaac aacttcttcg 3368101 atacggccta caagacggaa tgcatcttct ggaagatggt catatttacc ggctaagatt 3368161 tctttgaagc cttgtaccgt ctcttttaca ggcacgtaag aacctttttg tccagtgaac 3368221 tgttcagcca cgtggaagtt ctgagaaagg aagaactgga tacgacgtgc gcggtgaacg 3368281 acaagtttgt cttcctcgcc taattcatcc ataccgagaa tcgcaatgat atcctgaagc 3368341 tctttgtaac gctgaagcgt tgactgtact tcacgcgcaa ccgcatagtg ctcttctcca 3368401 acaatttcag gagcaagggc gcgtgatgta gatgccaacg gatcaaccgc agggtaaata 3368461 cccatttcag ttaatttacg ctcaaggttt gttgtcgcat ccaagtgagc gaacgttgtc 3368521 gccggcgccg ggtcagtgta gtcatcggca ggcacgtaga tcgcctggat agatgtaact 3368581 gatccaacgt tcgtagacgt gatacgctct tggagctgac ccatctcagt tgcaagcgtc 3368641 ggctgataac caaccgctga aggcatacgg ccaagaaggg ctgaaacctc tgaacccgct 3368701 tgtgtgaaac ggaaaatgtt atcgatgaag aacagtacgt cctgtccttg tacatcacgg 3368761 aagtgctcag ccattgtaag gcctgtcaaa gcaacacgca tacgtgcgcc cggcggctcg 3368821 ttcatttgtc cgaataccat ggctgttttg ttgattacgc cagagtcact catttcgtag 3368881 aaaaggtcgt tcccttcacg agtacgctct cctacgccgg cgaatacaga gataccgccg 3368941 tgctcttgcg cgatgttgtt gattaattcc tggattaata cggttttacc tacaccggca 3369001 ccaccgaaca atccgatttt accgccctta atgtaaggag caagcaaatc aacaacttta 3369061 atacctgttt caagaatttc aacttctgtt gaaagctgat cgaatgaagg cgcctgtctg 3369121 tgaatcggat cctttttcgc atccgcagga accggctcat tcaaatcaat attttctccg 3369181 agaacgttaa atacacgtcc aagtgttaca tcaccaaccg gtactgagat tggcgctcct 3369241 gtatctacag cttccatacc gcgctgaaca ccatctgtag atgccattgc gattgtacgg 3369301 actgtatcat cacctaaatg aagagcgacc tcaagcgtta aatcaatacc tacttcgttt 3369361 tcacttgcag ctggctgtga aattttaatc gcattataaa tttcaggcaa gtgaccgtct 3369421 tcaaaacgca cgtcgacgac cggtcctaat acctggctaa cgcgtccttt cttcatcgct 3369481 atccctcctg acaaaatctt tctattctaa agcggctgct ccgccgacaa tttccgtaat 3369541 ttcttgtgtg atggctgctt ggcgagcgcg gttgtaagaa agcgaaagtg aatcgataag 3369601 ttccttcgcg ttgtctgtcg cgtttttcat cgccgtcatt cttgcagcgt gctcacttgc 3369661 tttactgtca agaagcgcac cgaagattaa gctttctgca tattgaggaa gcaaaacctc 3369721 cagaacctcc tcttcagatg gttcaaattc ataagacgcc gttctttttc cgccgccgct 3369781 gcccaaatca gataacggca gaagtttttt ctccgttact tcttgagtaa tggcgctgac 3369841 aaaatggtta taaacaaggt gcaattcatc aaacgcaccg tctataaaca tttgaatcgt 3369901 ttgacgggca agatctttaa tttctgtaaa cgttacttca tctccaagtc ctgttaactc 3369961 ggaaatgatc ggaatctccc gtttcttaaa gaaatcacgg cccactcttc cgatggcaat 3370021 caccgcatac tcatccttag actgatgacg ttcttgcatg gcctgataag cactccgtaa 3370081 aaccgaactg ttaaaagcgc cggcaagacc gcggtcagac gtaatgacaa ggtatgccgt 3370141 ttttttcact tctctgctga gaagcatcgg gtgcttcacg ttgccggaaa ctcttccgac 3370201 gtttgacaca acctcttgga ttttatccat atatggcaca aatgattttg cattgttttc 3370261 agcacgattc agcttagccg cagataccat ctgcatggct tttgtaatct gacttgtttt 3370321 tttcgttgac gtgatccttg acttaatatc gcgtaatgag gccaaagatt tcaccacctt 3370381 ttctcttcat ctgcgtaaaa agagagaaaa agagaacctt tttctctcat cagcattcga 3370441 gttagttgct tggtgcaaat gtgcgtttga agccttcgat tgcagctttg aagtcttcat 3370501 cagcaggaag gtttcctgtt ttcgcaattc cgtcaagcag gtctttatgg ttttggtcaa 3370561 ggtacatgta gtactcttct tcaaaacgtc tgatatccgc cacaggaata tcatcgagat 3370621 atccttttgt cagcgcataa agaatagcta cttgcttttc aaccggaagc ggcttgttca 3370681 gatcctgctt cagcacttca actgtacgcg caccgcggtt cagttttgcc tgagtcgctt 3370741 ggtcgaggtc agaaccgaat tgagcgaatg cttccagctc acggtatgac gcaaggtcaa 3370801 gacgcaaagt acctgatact tttttcatcg ctttgatttg cgctgagccg ccgacacggg 3370861 atacagacaa tccggcattg atcgctggac gtacgcctga gaagaacaaa tcagattgca 3370921 ggaagatctg tccgtcggtg atggaaatga cgttcgtcgg aatataagca gagatatctc 3370981 cggcttgtgt ttctacgaac ggcagagctg taattgatcc tgcgcctttc gcgtcgctaa 3371041 gctttgctgc acgctcaagc agacgggaat gaagatagaa tacatcccca gggaacgctt 3371101 cacggcctgg cggacggcga agaagcaagg acagctcacg gtaagcggcc gcttgtttag 3371161 aaagatcatc gtatacaaca agaacgtgct tgccgttgta cataaattct tctgccattg 3371221 taaccccagc atacggtgcc aggtacagaa gcggtgccgg ctgtgacgca gacgccgtta 3371281 caacaattgt ataatcaagc gcgccgtgtt tacgcaatgt ttctactacg ccgcggactg 3371341 ttgattcttt ttggccgatc gcaacatata cacagatcat gtcttggtct ttttggttca 3371401 ggatcgcatc gatcgcaaca gatgttttac ctgtttgacg gtcaccgatg atcagctcac 3371461 gctggccgcg gccgattgga atcagtgcat cgatcgcttt gataccggtt tgaagcggtt 3371521 catgaacgga tttacggtcc ataacgcctg gtgcagggct ttcgatcgga cgagttttgc 3371581 ttgtcagaat cgggcctagt ccgtcaaccg gctggcctag cgggtttaca atacggccga 3371641 ttaactcttc accaacagga acctccatga tgcggcctgt tctttttact tcgtctccct 3371701 cacggatctc actgaaaggt cctaagatga cgatacctac gtttgattcc tcaaggtttt 3371761 gagccatacc caaaacaccg tttgaaaatt cgacaagttc accggccata cagttgtcaa 3371821 ggccgtgcac acgtgcaata ccgtcaccga cttggatgac tgtacctacg tcttgaactt 3371881 caatatcaga ttgataattt tgtatttgct gttttatcag cgtgctaatc tcttcagctt 3371941 tgatgctcac ttaggtttca ccccttctat cgattttccc cggctaattg acgttcaatg 3372001 cgctgaagct tcccgcttac gctgccgtca taaatccggt ttccaatgcg gactttaata 3372061 ccgcctatta aatccgtctg cacttcattt ctgattctca gtgaagcgac tccggctttt 3372121 tttgcaaaca cttgtgataa tggtaacatt tctgcatccg tcagcggttt cactgaatat 3372181 acgattgcgt cttctgtttg acgggccaca tttgcgagtt tgataaactc atctgtgagc 3372241 tcagggacaa tcgcggcacg atggcggtca atcaaaagaa aaatcgtatt gagtacggac 3372301 tgtgacaaag agccaaatgc attttgaatc agctcttttt tcttcgcagc cggcaccttc 3372361 ggatggttca acacatcatt aagcgctttt tcattttgaa atacttgttt tacaacaatt 3372421 agctcttctt ctacttgatt cagctgagcg gactcattgg ctatatcaaa aagagctgat 3372481 gcatatcgtt tagagacagc tgatccactc atcggctttc tcctacctct ttaagatagt 3372541 cctggatcaa tttctcttgc gcttgttcat ccagttcttt ttcgatcact ttcgacgcaa 3372601 tcatgacaga aagagacgct acttgctcac ggagagcaga aaccgcctgt tccttttcct 3372661 tcacgatttc agttcttgct gcttctttca gacgttcaga ttctgcacgt gcagcctgaa 3372721 taatctcttc tttttgcttc tctcccagtt tctttgcgtt ttcgataaga gtttgggatt 3372781 cctgtcttgc ttcttttaaa agaacgcgct gctcttcaat cagctgctgc gcttctttat 3372841 ttttttcttc agcagacgta atttctccag cgatgtggtc ttcacgctgt ttcattatgt 3372901 ttaatagcgg ccctaaagcg tatttcttca gaagcgctaa taagattaac atagctaaca 3372961 gttggaacag gatatctccg ccgttaaacg acaatcctag ttcaagtggt aattgagaca 3373021 tctactacgg caactccctt ctgcaggttt ttctttgctg atccagcagc cgcacttgtc 3373081 tcttttcagc cggcaaggcg ggatgcttat cagacataaa gcaatggcga aggttctctt 3373141 ggaatgatct tcgccatttt tagttcatat aaggctttta tgcttagcca aagaacgcta 3373201 agaatgcgat aacgacagcg ataataggaa gggcttcaac taatgcgata cccatgaaca 3373261 taagagttct cagttcttta cctgcttccg gctgacgggc aatcccctct accgtacgtg 3373321 aaacaatcaa accgttacca atacctgcac caagtgcgcc taaaccaatt gcaatcgcag 3373381 ctgctattaa attcatgaaa aagttcctcc tttaaaatgt tatccgtttg gatataatgt 3373441 tttaatgatc atgactgatt ttatgagaca tgtacaccat cgtcagcatt gtaaagataa 3373501 atgcctggat agcaccaata aataaactga atgcttgcca tgccagcatc ggcagaatgg 3373561 caccgattgt accgacaaga ccgagagcca cgctttgcga ataatggctt gttgctaatc 3373621 ccgcaagcag gccgagaaga atctcaccgg cgaagatgtt accatacagc cgcaaaccta 3373681 gagtcagcgt attcgcaaac tcttcgatga ttttcatcgg gagcatgaat ggaacaggtc 3373741 ttaaatagtc tttggaatat tccttgagcc ctttcatctt cacaccatag tagtgggtta 3373801 aagcaacaac catcacggct agcgttaatg taatggcagg atcggctgtc ggagacttcc 3373861 accagagctc atgtccgatt gtaatagaga acggcagccc cagcatattc gacacaaata 3373921 tgtacatcag caatgtgaca ccaagtgcca agaagttagc ccctgttttt aaatccattg 3373981 tactgccaat aatattgcgg acgaaatcaa caatccattc cataaagttc tgggcttttc 3374041 cgggacggat cgaaagcgtt cttgtcgtca atatagcaat caataaaaca atcacactcg 3374101 ccacagtaat catcagaatg tttgtcagat taaaagtaag acctagaaat tctatagttc 3374161 tgtaaccatg attcaaaggg ttttcacctc tcttccattg atgaacgttt aagctggata 3374221 aaggaatcta tcataatgac agggtatatt gtcattaatc caataactgt acttgccata 3374281 tgaaagtatt cgggattttt ataggcaaca gccacagcaa gaatcgcatt gcaccaccgc 3374341 gctgcgctcc cgagagatcg tatggacttt cctttctcta cagctctgtc aaaagcattc 3374401 attcttctga cgagcagtaa aaaattaaac aaactgaaaa cagttcccag aataaggcct 3374461 aaaaaaacgg ttttatacgc tgttaaacca taacccagta catacactgc caaaatgaac 3374521 aataaatatt tgcgttgtct gctaaatgta agcttgggat cgtccatcaa ttatctgtct 3374581 cctgatgaaa aaataatgta tagcttggat acggcaaaaa tcagcggtta acccttagta 3374641 gaagaccttt tttgaccggc aaaacgggcc tgttcgaaaa aatcattcat ccgcaagcct 3374701 tgcagggatg ctgtttcatt cgcttaaata aatcctcata atacgggttt gctgagagga 3374761 tttacattga ggatgaggac tataatgaaa gctatgaaaa ccttctcata ataccctcgt 3374821 ttagcataca atagccccta acatgtgtca atctgtttaa agttaaaaaa ctttttatac 3374881 tttacgtctc cacagaatgt tcacattttc acctataatt gtatacagat tcaccgaata 3374941 gcaaaaaact ggataaaaaa atgaaacccc cttttgggga tttcattttt tattttgttc 3375001 caaacatgcg gtcacccgca tctccgagac ctggaacaat atatcctttt tcatttaatt 3375061 tttcatctag cgccgcaatg taaatatcaa cgtccgaatg atgcttctgc aattcttcca 3375121 caccctccgg cgctgctaca agacacatga aacggatatt tttcgcaccg cgttttttaa 3375181 ggctgtgaat ggcttcaact gcggaaccgc ctgtagcgag catcgggtca accacgatga 3375241 attcacgctc ttccacatca gaaggaagct tgacatagta ttccacgggt tttaaggttt 3375301 ctggatcacg gtaaaggccg acatgtccca cttttgccgc aggaatcagc tttaaaatgc 3375361 cgtcaaccat tcccaatcct gctctgagga taggaaccac tccgagtttt ttccctgaga 3375421 tgactttcga tttcgcagcc tgaaccggtg tattgatatc cacttcttcc agaggaagat 3375481 cgcgggtaat ttcaaatgcc atgagtgtag ccacttcatc tactaactct ctaaaatcct 3375541 tcgtacctgt attttcattc cgtatatatg tcagcttgtg ctgaattaaa ggatgatcaa 3375601 atacataaac ctttcccata ctgtgtttca gctccttttt tattgtccca tcaacaatta 3375661 cacacttcta ttgattctac aaaaaaagac attgagtttc aagaacatcg tcaaaaaacc 3375721 cgccgggcat aagcccaagc gggttttagg atcttaataa tctaattctt tatataaagg 3375781 aaatttatca gtcagagcag ctacacgctg tcttgcttct tcaagttttc cttcatcttc 3375841 gtggtttttc aatgcaagcg caatgatagc accgacttct tctaatgcgt ctccgtcaaa 3375901 accgcggctg gttacagcag ctgtaccaag acggatgccg cttgttacga aaggtttttc 3375961 aggatcatat ggaatcgcgt ttttgttaga cgtaatacca atttcatcaa gtacatgctc 3376021 cgcaacctta ccagtcagtc cgagcgaacg aaggtcaaca aggataaggt ggttgtctgt 3376081 tccgcctgaa acgagctgga tgccctcttt cgttaaggct tcagccagac gtttcgcgtt 3376141 tgaaatgacg ttttgtgcat atgttttgaa atcgtcctgc aatacttcac cgaatgaaac 3376201 agcttttgcg gcaataacgt gcatcagagg gccgccttga attccaggga agatcgattt 3376261 atcaattttc ttgccaaact cttcacggca aaggatcata ccgccgcgag gaccgcgaag 3376321 tgttttatgt gttgttgttg taacgaaatc agcgtaagga accgggtttg gatgaaggcc 3376381 tgccgcaaca agtcctgcga tatgtgccat atccaccatg aagtaagcgc cgacttcatc 3376441 agcaatttca cggaatttct taaagtcgat tgtacgagga tacgcacttg ctcctgctac 3376501 gataagcttc ggtttatgag cgagggcttt ttcacgcacg tcatcgtaat caatatattg 3376561 agtttcttta tctacgccgt actcaacaaa gttatattga acaccgctga agttgactgg 3376621 gcttccgtgt gttaaatggc cgccgtggga gaggttcatc ccaagtacag tatcgccttg 3376681 ctccaaaatc gtgaagtaca ctgccatgtt tgcttgtgcg cctgaatgag gctgaacgtt 3376741 tacatgctcc gctccaaaga tttccttcgc gcggtcacgg gcgatatctt caacgacatc 3376801 gacgtgctcg catccgccgt agtagcgttt gcccggatat ccttctgcgt acttatttgt 3376861 caaaacagat ccttgtgctt ccataaccgc ttcacttaca aagttctcag aagcaatcaa 3376921 ttcgatctta gtctgttggc gttcacgctc atttttaatg gcgttaaaca cttgttcgtc 3376981 ttgcgcaggt aaatgtttca tcagcgagat cctctcctat ccgtatcctg ttctttgttt 3377041 ttaccatcac tattgtacat ggtttttaag gccgatgtaa aagattattt ttaaaaaatc 3377101 taaattttta ttggtaaaaa cgaatattaa taacttaaat ttaatttaaa gttcggaatt 3377161 tatttcacta tcttaaaata aaagaaaaga ctggctatgc agtcctttca ttcgcactca 3377221 taaaccgccc gcactccgcc gattagtttc ggccgtgtac gcgccaatgt cacatgagct 3377281 gaaccgaggc tgttttgaga gacacgcaca gggacagcca ccggtttcag atgcatgccg 3377341 ataaacgtat cgcctatatc aattccggcg tcagcctgaa tggtttcaac aagaacagga 3377401 gacttcatct gcttaaacgc ataagacgcc atcgctccgc ccgcttttgg aacgggcacg 3377461 gcagaaacgg ttggaagcct gaacagcttg gctgtttctg cttcgacgac aagcgctctg 3377521 tttaaatgct cgcagcattg aaacgccaga tggattcccg ttttttcccg gagctcagca 3377581 agtccgctgt agatgctttc agcgatatct acactgcccg atgtgccgat ccggctgccg 3377641 gccacttcgc tcgtgctgca tccaaggacg aagagctgat cttgtttcaa ttccgcttgg 3377701 tcctgaaact cagacagcat cgtcttccac gtttgtttca actcattcat taaacagcac 3377761 ccctacaggt ttttctcttc ataatcggag atttttccaa tacgcgtttg gtgtcttccc 3377821 ccggtaaact cagtagtcag ccagattttt gcgatttccc gagccaaacc aggtccgatc 3377881 acccgttcac ccatcgcaag gatgtttgtg tcattatgct ccctcgtcgc cttcgcgctg 3377941 aaggtatcgt gcgccagcgc gcagcgaatc ccttttactt tattagcgga aatgctcatg 3378001 ccgatgcctg tcccgcaaat taaaatgcct ctgtcaactt cgccgctaac cactttttcg 3378061 gccaccggaa aagcataatc cggataatcg acagagccgc tgccgcagtc acagcccata 3378121 tcaatatatt caatttgcaa ttcgtccatt aactctttga tttcatttcg aatgtgaacg 3378181 ccgccatgat ccgatgcaat ggctactttc atctgctttt cctcccagcg tgtgtgatgc 3378241 ggcccgcccg ctttattgac cgcgcagcct gtccgctctt tgattcacac catatgatgt 3378301 gcttttcact atattctact ccttcacgca ggatttgcaa atgacctgtt tgcagatttt 3378361 ctgacaactt atctacggtc ttttttcagc tgttttgcca gctgccgaag aagctcttca 3378421 agctcatctc gcgtttgttt atagatgtca attgagccgc cgaacggatc gaggacatca 3378481 ccatggctgc ctgtgacata ttcttttaac gtaaacactt tatcacgata acgtccaaat 3378541 tggctggcaa tgatctgttt gtgctgatgg gtcatagcca gaaccaaatc agccgattcc 3378601 ataagttctt cagttaatgg agaagacaca tgattaaggg caatgtgttt ttcaaacagc 3378661 gcttcgactg catgaggcgt cgctttccca ttaggtgaag caaacacgcc tgccgagcgg 3378721 acattgacat tcagcccttc cctttctgca attgatttaa aaagcgcctc agccattggg 3378781 ctgcggcacg tatttccagt acagacaaaa ataatatcca tgtcagtcac cccttatttt 3378841 tctctattat atatgaagaa aaaagaaacg gcgacttcgt ttcttttatt ggtatattaa 3378901 attggcaaaa gcagctttaa tccaaacacg attaatatga tgcccccgag cgcttcgctg 3378961 tatgtgccaa gccatgactg cacttgtttt ccgaccagca ggcccagcca tgtcaacatc 3379021 atgctgaaca gcccgaacag ggtaattgtg aggagcggat gcgagccgta tatccccaag 3379081 ctcaagccga cggaaaagct gtcaaggctg acgccgatgg caaacagcaa taagcccggc 3379141 cctgccggtg acatgaatcg ttcttctgac tgtttaaaag aggccataag catttgaacc 3379201 ccaagaacaa aaagcagcgc cccaccgata taaaccgcta acacgccgag gagccctgac 3379261 agcatgttac cggccgccat ccctgcgaga ggcatgatga cgtgaaagag gccgatgatg 3379321 aaaccaatat agaatatctg cttctttcta agtttgacca tgcccattcc aaggccgaca 3379381 gaaaaagcat ccatccctaa agcaaacgcc atgatgctta atgtaatcag ttcgcctata 3379441 aacaaatccg acatacataa ataaccccct tggacacgcc ccgctttttt agcctatgcg 3379501 tgtccaaaaa gggttagaac atctgactgc tttcagcgaa tcactcttcc tccggcggct 3379561 ttcatcagcc tgttcataat agcaagaccg acacctgtat ccggaaagga ttccgctata 3379621 atgaaatcca ccttattctc atcaaagctg cgcaaagcat catacagccc tgccgcaaca 3379681 gtctcaagct gagcccgtct tccgcagctc ttcacataat cagcggaata aacgcccgct 3379741 ttttcttctg tcgtcaggac accgacccgt cttccaccct gttgatattc ttgaatgagg 3379801 tgctgaatgc gctctgggct gccttcgcaa atggcaagag gcgctgtcgg cgcataatgt 3379861 gtatatttca tccctggaga aatcggcttc tcgttttggt cgctgagccc tttatccaca 3379921 tggatcggcc cgatcaccgc ttcaatttgt tccttcgtaa tgccgccagg acgcaagaga 3379981 acagggatgt cgtccgcaca tgaaagcaca gttgattcga ccccgattcc ggtagggcct 3380041 ccatccacaa taccggctat gcggccatcc aagtcgtgag ccacatgctc cgcttttgtg 3380101 ggacttggct tgcctgatag attggcgctc ggtgctgcaa tcggcagtcc cgattcgcga 3380161 atcaatgcaa gggcaagcgg atgatccggc attctaatgg caaccgtttc aagacctgcc 3380221 gttacacgag gtgaaagcgc atcaggtttg caaggcagaa tgagcgtaag tgctcccggc 3380281 caaaaccgtt tcatcaatgt tttcgccttt tccggcgccg ggcccgttaa atcctcaagc 3380341 tggctgatat ccgcaatgtg gacaatcagg ggattatcgc tcggccgccc tttcgcctca 3380401 tatatttttt tgacggcatc cgtatttttt gcgtttgcgc ctaggccata tactgtttct 3380461 gtcggaaagg caacgacctc attttctcgg agcaaagcgg ctgcttgtgc aatttgtgga 3380521 tcatttgtgg ataactcgtc agttacatcc acaaaccatc ttttcgtttt catttctgac 3380581 caaactcctt attcacaaca ataaaacgat tgttttacgc gtgtaatcct tttgaaagta 3380641 taaaagatgt cctgtaataa aacaagcgtt atccacaaat tgtggacaac gctaataaag 3380701 aagtggataa gtatgtgtat aaactgcact tatccagacg cttttttcat caaaacggct 3380761 ccttctgttt gccgcgattc acagaagtga tcagaagaaa acagctcctc cggtacactc 3380821 tcagctcttt caaaacccat ggccgtcaga aagtccgcag aggaatgctg atttgctact 3380881 aggtacacgg ttttgatctg atgcttttcg cacagcacct ccatgctttg aaaaagcgtg 3380941 acgatgtggc cttggtgaag cttgtccgat atgacaagtg atcgcagcag cccctggtca 3381001 cagcttattt tttcaatacc gaggcatccg gcaatgtttt tctcactgtc ctccagcata 3381061 agaaattgag tgaagccttc tttcacgcct tcatagctgg tttttgcctg ttttaaaaat 3381121 gcctcgagca catctccgtc tttttccctt gccacccgca gttgataaaa catccgttca 3381181 ccccgttttt gcgttctttc ttccaatcta tgaggcaaat ctatttttag accagatgat 3381241 taggaaaaaa ggtcggaaat ccattcgact aaaaagaatt tcacttctgt gccgtcttct 3381301 ttttcttcgt tctcttcttt tttggctttt tccgctttag cggttacgtc ctcaagcact 3381361 ttttcagtct gcttttttga ggcttcttta tcttcttgtt ctttgacggc ttccccgtta 3381421 gaaaaatcaa gaaagcagag gggcgggaac agcacacacc accagttggc gccgtctccg 3381481 tttccaagcg taatcaaaat cgcttcatac tcaccagcgg gatataccat gttgccgtaa 3381541 agctttgtcg gaaacgagat tttgtcaaaa tcaacggata tcgactgatt cgctccttct 3381601 ttctccattg tttcctttgc aattgctttg atttcaggca gctttgaacg aatcacgcga 3381661 cgcgcttctt caatagaagt aatatccttt acccaagttg tgatttcttt attcaccgcg 3381721 tctcttatat gacgttttaa ttgctggtct tgatcactat cgctgtttgc cagtattctc 3381781 aaacgaatcg cctgatcagg tatgaccacc ggctgatttt ccgatttttg tgccgtctct 3381841 tcttttgcca gccctacgag cgctccggat aataaaagaa agatatatat acaaatgatt 3381901 actgtttttt tcatcggtcc ccaccgttcc tctccgtgct ttgtttctag ccctattatg 3381961 gacaaggaga gcctgggata aacgtgcagg gtgaaaaaaa tctagcaagc tgttaatctt 3382021 atttatggta cgatagtgtt ttaggaggtt taagatgaaa tacaattata cagtgctgtt 3382081 atcagcattc acgatgtccg ttctttattc agtaatttat attcattcat ttatcattgc 3382141 cgctctcatc acaatggcat tttattttct gtttccttat ttgatcttcg cactgccgct 3382201 tcaaatcatg atgaataaaa agccgaaacg tttcagccct ttgtatctgc tgtattacct 3382261 tgccgctgct tttattgcca acgcgatcat tttcggcatg cttcagcctt cgggacaatc 3382321 tctgtttcaa aatacagcct tttatctttt cgctgtatta acagctctta tctattggat 3382381 atgggattct gttttactgc aaaaaaagga agcctaagag gcttcctttt ttattaaaac 3382441 aaaatcgtca gtaaataaca tagaatggaa ggtatcgccg caacaaagaa agcggccgcc 3382501 attttcatgc gagatgtacg gccttctttg gtttctgaat ggtagtttgc ccgctgatcg 3382561 cttccgctta cagccaaacc cgatgtaatg atcgcgagcc ccactaaaac gagagacgca 3382621 acgccaaaaa tcgcttcata tgaaagagcc tgcggaaaaa tggtgccaat catgctctca 3382681 atcgcaatga gcaggattcc tgctgtcagg gcctttttca tgtttacatc ccctttgctg 3382741 gtgttaaaca gcttgatcca ttcactcgcc agcaagctgc ttatttattt ttatgaatca 3382801 gagcgcatat ggttctgtct tttccattaa tatctttcag cacttccact tccgccccct 3382861 taaacgcctt gaggatcagg tctttgaccg ccgctccctg tttccagccg atttcaaaaa 3382921 cgacaaatac tttatccttc ataacaagcg gaatgtcttc cataaaccgc ttataaaatt 3382981 tcagcccgtc tccgccatcg gtgagtgcgt gcagcggctc atgaaaacgg acaatttccg 3383041 ataaatcagc catttcttcc tctgaaatat atggcgggtt tgagacaatg atatccgctt 3383101 tttttcccgc cttaataaaa ggctcaagca gatcgccctg ataaaagcgc acattcgctc 3383161 cgagtttttc tgcattggca gaggcgactt gcagcgcctc tttcgaaata tcgaccgccg 3383221 acacagaaaa gctttggttt tcaagcgcaa gcgtgacggc tattgcgccg ctccctgtac 3383281 caacgtcaac aacttcgagc ttgccgtctt cagaaaaaac actccgatat ttttcaagca 3383341 aatgaaagac aacttcttca gtttccggcc gcgggatcag cacatcatca ttcaccataa 3383401 attcccgtcc ataaaaaaac tcttttccta taatgtattg aaccggcacg ccctctttat 3383461 gcatctcaac gtgacgctta aagcgataca gttcgtcttc accaatcggt tcctgtaagc 3383521 ttgcgagcag cttgcttctc tccattccgg tatcataaag caataggagc tcggccgcat 3383581 tttcttctct tcccgcttcg gttaaataag aagaagccca tttcagggct tcgaatatcg 3383641 tcttcatctt aaccttccga ctgctgaagc ttgcttgcct gatcttcaac aatcagcgct 3383701 tcaaccactt cgtcaagttt tccttcaaga atctgatcaa gcttttgaat cgtcaaaccg 3383761 attctgtgat ccgtcacacg gttttgcggg aagttgtatg tgcggatacg ttcagagcgg 3383821 tcaccagatc cgactgctga tttccgtgtt tgatcatatt cagcctgggc ttcctgctga 3383881 aatttatcat agattctggc acggagaacc ttcattgctt tttctttgtt cttaatttga 3383941 gatttttcat cctggcatga tacaacaaca cctgtcggca agtgagtcag acgaaccgca 3384001 gacattgttg tgttaacgct ttgtccgccc ggtccgcttg aagcaaatgt atcgacacgg 3384061 atatccttct catggatgtc gacctctacc tcttctgcct caggaagaca tgccactgtt 3384121 gcagtggatg tatggatgcg tccgcctgat tctgtttccg gaacacgctg tacgcggtgg 3384181 gcgccgtttt catatttgag tttagaatac gcgccgcttc ctgtaatcat aaagatgatc 3384241 tctttgtagc cgcccgttcc ggttacattc gcttccatga cctctgtttt ccagccctga 3384301 agctcagcat aacgggaata cattctgtac agattgcccg cgaataaagc ggcttcctcg 3384361 cctcccgcag ccccgcggat ctccatgata acgtttttgt cgtcattagg atctttcggg 3384421 atcaggagca ccttcagccg ttctgacagt gtttccgttt ccttctgaag ttcagaaatc 3384481 tcttccttca ccatgtcgcg catctcagca tccagcttct cttcaagcat cgcttttgca 3384541 tcagccagct gttctgacgc atctctgtat tgtctatata cgtcaactgt ttcttgtata 3384601 tcagattgct cttttgaata ttctcttagc tttttcggat cgttgactac ttctggatcg 3384661 ctcaaaagct catttaattt ctcgtatcgt tcttcaattg attttaaacg gtctaacacg 3384721 gtcttcacct ctgttttcct gtgcgtaaca ttctcattat agtatagtga ttaaccccag 3384781 tcaaaagcat ttcaatccca gctggaaaag ctccctctgc tatactggaa ttcgaggagg 3384841 gatgatgttg ctgaaatcca tacatcatat tgcaatcata tgttcagatt acgaaaagtc 3384901 gaaagctttc tacgtacata agcttggttt tcaggtgatt caagaaacgt accgcgaaga 3384961 gcgcggctcc tataagcttg atttgtcgct taacggctcg tatgtcattg agctgttctc 3385021 gtttcccgat ccgcccgaac gacaaacccg gcctgaagcc gcaggcctgc gccacctcgc 3385081 ctttacagtc ggcagcttgg ataaagctgt tcaagagctt catgaaaaag gaatcgaaac 3385141 agagccaatc agaacagatc cgctgaccgg caagcgtttc accttctttt ttgatcctga 3385201 ccagcttcca ttagaactgt atgaacaata acagtttttg aagaaaaaaa ggagataccc 3385261 actttctttg ccgaatcttt tcttgttttg tctaacggga agggaaccgc attctatggt 3385321 cgaataccta gcttaaaagg aggtatggga tcatgaatac aaatatggta gcaagtgaac 3385381 tcggcgtctc cgcaaagacg gtgcagcggt gggtgaagca gctgaatctt ccggccgaac 3385441 gcaatgagct cggacactat tcgttcacgg cagaagacgt gaaggttcta aaatccgttc 3385501 aaaaacaaat ctctgaaggc acggcgattc aggatattca tctgccgaaa agcgctaaaa 3385561 agcgcacagg cttccttgtc caaaaaacaa gtagcgacac agaacgaaga atcgagcagc 3385621 ttgaacaaaa gctggacacc cttttacagc aaaggcagga cgaaagcgaa ttgatggcaa 3385681 ggatgtcgga actggaacgc cagctgaaac aaaaagccga tgaaggtgta tcttaccagc 3385741 tgcttcagca ccgcagagaa atcgatgata ttcttgcaga tctgcaatca ctgacctcac 3385801 aaatgaaaga attcaccgct cattcgatcc ccgagactgc tgctgcttct gaaaaaacca 3385861 aaacaagaaa aaaaccgctg ctgtcactgt tcaaatttca aacctaaagc aaaaagctcc 3385921 cttaaaggga gctttttttg ttacgcagta agcgcgataa tgattggaag tgaaatcaat 3385981 gacagaatcg cactgaccac aaacgcagtt gcagtttctt cttcttgttt ctcgaaacga 3386041 gtcgcaatca tggctgcaac ggcagaacca gggaatgcaa caagaaggat tgcttttgtt 3386101 gtttggtcag ctggaagtcc gatagcaaga gcaatcagga acattaacgc aggctgaacc 3386161 gcaactttta gtaacgcaat accgatagcc ggcatactga gtttaatttt acgaatacca 3386221 acggtaacac caacagcgaa gagagcaaca ccagatgttg tgcttccaag ctgatcaagc 3386281 attttaacac ccagctcagg aagagtgaaa ttgaaaacca gcaccaagat catactgatt 3386341 aacggagcag ctgcaagcgg ctcacaaaga ccatgcagga ttgattttcc tgtcatcttc 3386401 cagaagctgt cgccactctc ttcgtttttc ttagaagact caccaacagt agcgataatg 3386461 atcgcgagcg gatcaagaat cgcgttaacc acgatacctg tgaccgcgat cggaatcgca 3386521 acttcattcg ctccgaataa gcttcccaat accgggatac ccataaatgc gaatgtcggc 3386581 tgtgcagagt tcaaagaaaa tacagatgag ttcgttaaat catacttgaa tataaatctg 3386641 caaaccaaaa gaatgatgat atagaaacca acaatcccaa taattaaaga aatcattaaa 3386701 ggtacttgtg ataaaaattc acttctggaa gttgtcaaaa taccagcgat aaagtgagct 3386761 ggaagtgcgt atttcgttac taacgtactt accccttttg ccgacttggc atcataactt 3386821 ccaaaatgtc ctgcaaacca acccagcacg ataacaaaga agatcggcgc caggaggatt 3386881 aagatatcta agatgctcaa aatattctcc tccaaatcct atgtccgtat actttagctt 3386941 tacaaaaagc tttccctcgg acagaaaaat ttactcgcta attatttcgc gatgactttt 3387001 ttgtattcag gtgtccacat tgcatcaagt accgcttgtt tcacatcttc aggctgacga 3387061 tttgccacgc cgtctttaat tgctgcttca gcaacggcaa tcgcaacttg gatagaaacc 3387121 tcttgaagct tatcaatgct tggaagcaat cctgctccag gtgtttcaag atcaaccatt 3387181 tcagcaatcg catcagcagt tgcagcaaac atagcaggtg taatgatacg cgcttcagct 3387241 acaattgaac caagtccaag accagggaac gcgaatgcgt tgttagattg tccgatttca 3387301 taagaaacac cgttgtattc tacattgtca aatgggcttc ctgttgcaat aagcactttt 3387361 ccgtcagtcc atttgaacag atcttcagga acagcttcag caaggtgagt cgggttagac 3387421 atcggcatga taaccggacg gtctacgtga gatgccattt cttttacaat ttcctctgtg 3387481 aatgcacctg aaacccctga agtaccaatc aagattgttg gtttcgcttg acgaacaact 3387541 tcatcgaatg gaatttgacc tttttcatcg cgcttccagt ctttcacttc atccgcattg 3387601 cgaaggtaag gtttttggaa atcaaggatg ccttcgatgt cttcagtcag caagcctctg 3387661 taatcaagtg tgtagaaacg tttgttagct tcttcttcag ataatccggc tagcaccatt 3387721 gtgtcacgga tttggtcagc aataccgata ccagcagaac cagcaccgaa gataacaaca 3387781 cgctgatctt taatagaagc gccggttttc ttcatagcgg caagcacacc tgcaagtgta 3387841 atcgcgccag taccttgaat atcatcatta aatgtcagga tttcatgatt gtattttttc 3387901 atgatgttgc gtgcattttt gttgccaagg tcttcccagt gaagaagcgc tttagggaag 3387961 aatttcaatg cagcttttac ataagcgtca atgaaagctt cgtagcgttc accttgaaca 3388021 cgttcatgct tgttaccaat atataaagga tcgtttagaa gtttttcgtt gttcgtaccg 3388081 acatcaagca caaccgggat aacacggcta gggtcaatac cagctgcagc agtgtagaca 3388141 gccaatttac cgattgcaat attaataccg cctacacccc agtcaccgat accgagaatg 3388201 ctttcggagt cagtagcaac gataagatca atatcgcctg ctgtcgcatg aaggttttca 3388261 aacgcttttt caataccgtc aatgttatcg attgacaagt agattccttg aggtcttcta 3388321 tattcatggc tgtattcctg aatcgcttca ccaactgttg gcgtgtacac aacaggaagc 3388381 atttcgcgaa gatggttttt cagcaattta tagaaaagaa cttcgttacg gtttgcaaga 3388441 tcacttaagt aaacattttg acgaaggcgg tcaggctgcg cttggaattg ctcgtacgcg 3388501 cgttgtgctt gttgatcaag agaaagtaca gttggcggca gaagcccttc taagccgagt 3388561 tcttgtcttt cttctagtga aaaagcaacg cctttattta aagtaggaat agataaaact 3388621 tcttttcctc taagagttgt ttctaagtgg ccttctttcg ttttttttat gttattcaag 3388681 caaatctcct tctttcttga aatagttaac caagttaagt aataacccat ctaaaatatg 3388741 accgatcatg atctttatgc gactttgtga caattattcg aacaatgtct caaaactatt 3388801 tacattacgt aagctattgt atgcctgtca aaatcaaaat tcaagagaag aaaattactt 3388861 aattttttaa tatacttatt taaatttttt aattgaatat tatcagaata taaaaaaaac 3388921 accggtgttt ttagccggtg cattctatct ttatacccat gttttggact attttttaga 3388981 tttacctggg acttcgtgat gatgtctgca tcttgcttca tatgattcag ctgcaccaac 3389041 caaaatgacc ggatcatcgt aagaagcagg tttgccgtca atgaggcgct gtgttctgct 3389101 cgccggtgat ccgcaaacag aacagacggc ttgcagcttt gtcacacttt ccgcaatcgc 3389161 catgatattc gggacgacac cgaacggctc tcccctaaaa tccatatcaa ggcctgctgc 3389221 tatcacacgg tagcctttat cggcaagaga tgataaaacc tcaacaattt cctgatcaaa 3389281 aaactgcact tcatcaaccg caaccacatc tgtactttca ctgatgtgat cccaaatgtc 3389341 cgcagcagac gaaatggcat agctcgtcat cgatgttcca ttatgggaga caacagcagc 3389401 ttcgctgtat cggttatcaa ttacaggctt aaataccctg acttcctgct tggcataagt 3389461 tgctctcttc actcttctga tcagctcttc agatttcccc gagaacatgc tgccgcaaat 3389521 cagctcaagc cacccgcttt gtttcattat gtacataggc ttcgctcccc tctctctgcc 3389581 agctgtgttt tagacaatat aaaaaacagg caagactgct gcttgcctgt tgagaaatct 3389641 attattactt aagaccgtat tttttgttaa agcgatcaac acgaccatca gcagaagcga 3389701 atttttgacg gccagtgtag aatgggtggc attcagagca aatctcaacg cgtacctctt 3389761 cttttactga gcctgtttca aattcatttc cgcaagcgca tttaactgtt gcttttttga 3389821 aattaggatg aattcctgct ttcattgtat ccatctcctt ccgccctgaa tcccgtgtgg 3389881 aaacagagtt attatttcgg agcattgtcc gaaacgcata tgagaaaatt atatcagtga 3389941 tttacttctt ttgcaaatac aatttacctt cttgcagatg atagatttgc ctgtttccat 3390001 tcttgattga gaatatcgaa aaattcctgg tttgttttgg tttttttcat ttttctcatg 3390061 aacttttctg cgaaatcagg tgaatcagac atcgttttgc ggatagacca taaacgatca 3390121 agatgctctt taggcacaag cagctcttct ttgcgcgttc ctgaacggcg gatatcgatg 3390181 gcagggaaga tgcggcgctc ggcaagagag cggtcaagat ggagctccat gttgcctgtt 3390241 cccttgaatt cttcataaat gacatcatcc atacgtgaac ctgtatcgac cagagccgta 3390301 gcaaggatgg ttaagctgcc gccctcttcg atatttctcg cagccccaaa gaagcgtttc 3390361 ggacggtgga acgccgctgg gtcaatcccc ccggaaagcg ttcttccact tggcggaatc 3390421 actaagttgt aggcgcgggc aagacgtgtg atgctgtcca tcaggataat gacgtctttt 3390481 ttgtgttcca cgagacgcat cgcacgttca agcacaagct cggccacttt gatatggttt 3390541 tccggcactt catcaaacgt tgagctgacg acatccccag ctacagagcg ctcgatatcg 3390601 gttacttcct caggtctttc gtcaattaaa agcacgatca gctctgcttc aggctggttc 3390661 gctgtaatgc tgttggcaat ttccttcagc aacatcgttt ttccggcttt cggcggcgca 3390721 acaatcaatc cgcgctgccc aaatccaacc ggcgccatca tgtccataat tcttgtagac 3390781 aagaagttcg gctttgtttc aagcaccatt tgacgatccg gataaagtgg cgtaagagcc 3390841 gggaaatgca cacgctcttt tgcagattcg ggatcatccc catttactgc ttcaacgtgc 3390901 aaaagtccat agtaacgctc attttctttt ggcgggcgaa ccttgccaga tactttgtct 3390961 ccgttccgca aatcgaaacg gcggatttgt gaagctgaga tgtaaatgtc ttctgagctt 3391021 ggagagtagt tgatcggtct caggaatccg aaaccttcag actggatgat ctcgagaacg 3391081 ccttccataa acagcagatc ttcctgttct gcattcgctt tcagaatggc gaaaatgagt 3391141 tctttttttg tcagtttgct gtaataggag attttataat gtcttgcaag ttcataaagc 3391201 tctttcaatt tcatattttc caaagaggaa atagatacgt ctttcataaa aacaccacgc 3391261 ttttcatagt caatatctta ctctgaacat gtcatctgct gcttttgcac aacatccgcc 3391321 aaagcacatt ctttttttaa cataaaggaa cttctatcgg taacacttcc acccatgatc 3391381 ggcgcttttg ttaaaaggat tgtcttaatg agttttgaag gaagcgagga caaaaacatg 3391441 agaagatcaa tacttatatc gtctgtatgc ggtagaaatt gaaactttcc tagtgcttaa 3391501 aagaaggtat tacgcagtaa aattcgcagc actctttatt tttaccttat ttcaaaaaat 3391561 tattcaactg aaataaggtt ttgacacgga attgatagag ttgacgcttt tctgcaaaag 3391621 ttaaagcggg ctcacacccg ctttttctgt ttgttatgga cggattacaa gatttggttt 3391681 ctttttcaag ctgtgtctgc cgtcaacgaa acgaacagtg cccgattttg cacggataac 3391741 taagctttca gttgtaccga cagagccttt gaattgaact ccttttaaca gctcgccgtc 3391801 agtaacccct gtagctgcaa aaatcgcgtc atcacccttc acaaggtctt ccatgcgaag 3391861 cactttgctt aaatcaaggc ccattttgtg acagcgagtg atttcttctt cgctttgcgg 3391921 aagaagttta ccaatgattt ctccgccgag tgcttttagc gcaacagcgg aaagcacacc 3391981 ctcaggagcg ccgcctgatc cgaacaggat atcaacgccc gtgtggtcga aagccgtgtt 3392041 gatggcgcct gcgacatcgc cgtcattgat caatttgatt ctggcgccgg cctcacgaag 3392101 ctcggaaatg atttttgcgt gtctttcacg gtttaaaatt gtggcaacga cgtcctcaac 3392161 gtccttgttt ttcgcttttg ccaccgcttt aaggttgtca atgacaggtg cttcgatgtc 3392221 aatgcagccc accgcttccg gaccgactgc gattttttgc atatacatgt caggagcatt 3392281 cagaagcgtg ccatggtctg cgaccgcgat aaccgtcagc gcgttccagc cgccgcttgc 3392341 taagatgttt gtgccttcaa gagggtcaac tgcgacatca acgcgagggc cgtacccgtt 3392401 tccgagtttt tccccgatat acagcattgg cgcttcgtcc atttcccctt caccgattac 3392461 aacggtccct ttcatcggca ctgtatcaaa aacgtctctc attgcacttg ttgccgcttc 3392521 atcagcctca tctttttttc cccggcccat ccatcttgct gatgccaatg ccgcagcttc 3392581 tgtcacacgt accaattcca ttgataaact tctttccatt tcaacacgat ctcctctcac 3392641 aagaaaccat tatgaatttt gaagctgttc tatttcttcg tcagtcattc tttcacgcca 3392701 aattgtcgct ccaagcccct caagcttctt ctcaaggctg ctgtatcctc ggtcaatatg 3392761 ctccagtccc gtaatttccg tgacgccatc agccatcagt ccggctacca ccaagcaggc 3392821 tccggcacgc agatcactcg ccttcacttt tgcgccttga agctcgacag gacctgtgat 3392881 gatggcagat ctgccttcta ctttcatatt ggcacccatt cgtctcagct catcaatgtg 3392941 cttgaatctt gccgagtaga tggtgtctgt gacgacactc gtccctttcg cccttgtcag 3393001 gagcgccgtc atcggctgct gtaaatcagt cggaaacccc gggtatacga gggttttgac 3393061 gtcaaccggc tttaagttct tctgcccgcc gacaatgagg agctggtcgt cgcttgtttc 3393121 gatatgatag cccatttctc tcagctttgc cgttaacgac tcaagatgag tagggatgac 3393181 gttatcgata atgacttcct tgcccattgc agcccctgca atcataaatg tcccggcttc 3393241 aattctgtcc ggaatgatcg tatgcttgca gccgtgcagt tccttcacgc cgtcgattcg 3393301 aatcacattg gtgcccgcac ctttgatttt ggcgcccatg ctggtaagca atgtcgcgac 3393361 gtcaatgatc tcaggctcct tggcagcgtt ttcgatgatc gttttccctt ctgccaaaac 3393421 agcggcgagc ataatgttaa tcgttgcccc aacgcttacg acatctaaat aaatccgtgc 3393481 gcctctcagc ctttcagctc gcaaataaat ggcgccttgt tcattggtta cttcagctcc 3393541 gagtgcttca aagcctttga tatgctgatc aatcggacgg ggccctaagt gacagccgcc 3393601 aggcaatcca atgaccgcct gcttgaagcg gccgagcatc gcccccatta aataatatga 3393661 cgcgcgaagc ttttttactt tcccgttagg aagcggcatg ctgatcatcg acgtagggtc 3393721 aacaaccatt tccccattct caaaatgcac gttgccgccg atttccttta acaggtcacg 3393781 cagcgtttca atatctgaaa tctctggaag cccttcaatt gtcacctcgg aatttgccaa 3393841 aatggttgca ggtattaacg caacagcgct gtttttagcg ccgctgatat gtactgtacc 3393901 gtttaacgag tcaccgccgg caatattcaa cttttccatg atagtctcct tccataagaa 3393961 gatagctgcg gagctaaata aaatgtcatt ttattctgtc tctgcaaata aagctcatgt 3394021 ccaaaatcta gccaattcga agagaaagaa tacaacacat tgtaaaatat caggaagaaa 3394081 atagcgaagc tttggggggt acaggtttca aaagatgcac agagacccgc cggctcgaga 3394141 gacatcgtcg tcatccggca aaagcagtac gcataccctt cattccgata tcagcttctg 3394201 cagcccaatg attccttctc tgtaaagcgg cgtcagcatc tgaagatccg ctgtatcagg 3394261 tcggtgaaat acaaaggccg cggcaaacag gcataaagct gtttgccgcc cctttcatta 3394321 tttgttccag tctgccagga attgttcgat tcctttgtct gttaacgggt gtttagtgag 3394381 cgcatgaatg actttcagcg gcattgtgcc gatatgagcc cctctaagag cagcttctgt 3394441 cacgtgctgc ggatggcgga ttgacgctgc aatgatttgc gtgtcaaggc cgtgaatgtc 3394501 aaaaatctgt ttaacttctg aaatcaggtc aagcccgttg tggccgatgt catctaaacg 3394561 tcccaggaat ggagatacat atgttgcccc cgctctggca gcaagaagcg cctggttggc 3394621 attgaagatc aatgtaacgt ttgttttgat gcctaagtca gtaagtgctc ttaccgcttt 3394681 taaaccgtca gacgtcattg ggattttcac cgtaatgttc ggagcgatct tcgccagttc 3394741 ttttccttcc tcgatcattt cctcagcttt caaagaaata acctctgcgc ttacagaccc 3394801 tttcacgacg tctgtgatct cgcgaagacg gtcgtggaat gatacgttag cttcctttgc 3394861 tactaaacta ggattcgtcg ttacaccggc gagaattcct aattcattcg cttctctaat 3394921 ttcatcgata ttggctgtat caacaaagaa taacattttc aaaaagcctc cctgattaag 3394981 aaattttctg aactgcgaat atgattgcgc tttctaaaga tagacggaaa accgcctgtc 3395041 aagctgtcag gcggctataa aaagttccaa ttgaattaag cttggtttga agaaccaaat 3395101 tcacgcattt taccgataac tgtttctttg atcgcttcac gagctggtcc aaggtattta 3395161 cgtggatcgt actcgtcagg cttagctgcc aatgtttcgc gaacagcttt tgcagaagaa 3395221 atttggtttt cagtattcac gttgatttta gctgtaccaa gtgaaattga ttttttgatg 3395281 tcagcagtcg gaattccagt accgccgtga agaactagcg gaaggccagt tgattttccg 3395341 atctcttcca tttctttgaa gccaaggttt ggctcacctt tgtaagggcc gtgaacagaa 3395401 cctaatgcag gtgcaaggca gtcgatgcca gtgcgctcaa caagctcttg gcactcttta 3395461 ggatcagcgt agattacgcc ttcagcgata acgtcatctt cttgtccgcc tactgttcca 3395521 agctcagctt ctacagatac tccgtggaaa tgagcaagct caacaacttt agcagttgtt 3395581 gctacgtttt cttcaaatgg atggtgagaa gcgtcgatca ttacagatgt gaaacctgca 3395641 tgaatcgctt tcgcacaaga ttcaaagctt gaaccgtggt ctaagtgaat cgcaacagga 3395701 actgtcactt tgtactcttc cataagtgct tttaccatag caacgactgt tttgaagccg 3395761 cccatgtagc gtcccgcacc ttcggaaaca ccaaggatca ctggagattt ttcttcttca 3395821 gctgcttgta aaatcgcttg agtaaactca aggttgttta agttaaattg tcctacagcg 3395881 tacccttttt ctttagctgt attcaacatt tccgtcatag aaactaaagg catgtcgaat 3395941 gtcctcctta tgtagcctga ttgtcttcta gcgaaaaaag ctttccaccc tagcatgacc 3396001 catatattgc tgtcatatgt aaatactcag atcgcttttt ctccataact aggataccaa 3396061 cttttcgaca aatcggcaac ataatgacat gattcatttg tttcttcttt ttgtcagtta 3396121 gacttcaggg gcagatattt tttgacggcg tctctgattt cgtcgatgtc aaacggcttg 3396181 gcaaagtgcg tcagagcgcc caattccttc gattcctgga tcatgtcgag ctctccgtat 3396241 gccgtcatga taatgacccg gatgttttcg tcaatgacct tcatccgttt taagatttcg 3396301 attccgtcca tgccgggaat tttcatgtcc aacagcacaa ggtcgggccg ttcttttgtc 3396361 acaatgtcaa gcgcctgcag gccgttcgca gcctgaaacg tctggtagcc ttctttattg 3396421 aacacttcat ttagcaaaat acgaatgccg tattgatcat caacgattaa aattttttca 3396481 ttcatcattt tacaccccaa tattatgatt ttcgtcaaaa gtaagcagta ttgtatgtat 3396541 tctgtttgat tttcctattt cctttaatta taatagtcta ctttacgaca ttttctgagc 3396601 attttctctt ttgttgtata ctgatattgt acgttataaa ggaggattca cttatgttga 3396661 aaatattcac gacgcagtta acaggtattt tttcccgcat tcaggataag gaatctgacg 3396721 cgattgaaga tggggcgcgg ctgcttgctc aagcggtgat cagcgggcat tccatttatt 3396781 tatacggagc gaatgagctt cagggcgtct tttatgaggc caccgaaagc aaagaaccct 3396841 tcccatctgt caaagccttt ccagaaaacg ctgaggaagt gacagaaagc gacagggtgc 3396901 tgatgttttg ctcagggacg ggcacagccg aagaacagga gctcgcaaaa gagctttatg 3396961 aaaaaggtgc gggagtcgta tgcgtatcgc ccgcagccaa agacagtgcg ggaatagaac 3397021 agtattgtga tgtgcatatt gattctaaat taaaaatgcc gcttgttccc gatgaagacg 3397081 gcacccgtta cgggtttccc tctttaatga cagcactgta tgtctatcac gctttatcgt 3397141 ttacactaaa agaaattctg caagagtatg cataatatct tattgtacat gctggaactt 3397201 gccggaaaca aataaaaaag acttgcccgc ttttgacaaa cggcaagtct tttttattac 3397261 ttctgatttg cagcttcgac agacgctccg ataaagcctt tgaatagagg ctgaggtctt 3397321 gtcggtcttg acttgaactc tgggtggaac tgagaagcca cgaaccaagg gtggtctttc 3397381 agctcgatga tttcaacaag gcgtccatca gggcttgtgc ctgagaatac gaagccttgc 3397441 tcttccattt gctgtctgaa ttcattgtta aactcatagc ggtggcggtg gcgctcgtac 3397501 accacttcat cctgatacac ttcaaaggct ttcgtgcctt cttcaagctt acaagggtaa 3397561 aggccgagac gaagcgttcc cccaagatcc tcaacatcct tttgttcagg aagaagatca 3397621 atgatcgggt attgagttga cggatcaatt tccgctgagt gagcgccttt taagcccaat 3397681 acgtttcgtg cgtattcaat agacgccacc tgcatgccca agcaaatgcc caagaacgga 3397741 atgttgtttt cgcgcgcgta ttttgtcgcg acgattttcc cttcaacacc gcggtctccg 3397801 aatccgcccg gcacaatgat gccgtctgtt ccgcttgtga gttctgcgat attgttttct 3397861 gtcacttctt ccgcgttgat ccacttcact tttacatctg tgtcaaacgc atagcccgca 3397921 tggcggagag actcgacaac agaaatgtat gcgtcaggaa gctcaacgta tttgccgaca 3397981 aggccgattg taatcgtttg agacaggttg ctgactttgt taacaagctc tttccactcg 3398041 gacatttccg cttctttgca tgccaatttc atgtgctcgc aaacaagctt atcaagccct 3398101 tgtttttgaa gctccagcgg aatggagtaa aggttgtccg catcttcaca ttcaataacc 3398161 gcttttgtat cgatgtcgca gaaaagcgcg attttatctt tcatatcttg agaaatcggc 3398221 atttctgtac gaacgacgat gatgtttggc tgaatgccca agctgcgcaa ttcttttacg 3398281 ctgtgctgtg tcggttttgt ttttaattcg ccagcagctt taatgtaagg cacgagcgta 3398341 cagtggatgt acattacgtt ttcacggccg atgtcgctct tcatttggcg gatcgcttca 3398401 aggaatggca gtgattcgat gtctccgaca gtaccgccga tttctgtaat gacaacatct 3398461 gcgtttgtct ctttccctgc gcggtaaaca cggtctttca attcgtttgt gatgtgcgga 3398521 atgacctgta cggttcctcc aaggtaatct ccgcggcgtt cttttttaag aactgttgaa 3398581 tagattttac ctgttgtcac gttgctgaat ttattcaggt taatgtcgat aaaacgctca 3398641 tagtgaccaa ggtccaagtc tgtttcagcg ccgtcatccg ttacgaatac ttcaccgtgc 3398701 tggtacgggc tcattgttcc cgggtcaacg ttgatgtatg gatcgaattt ttgaatcgtc 3398761 acgttcagtc cgcggttttt cagcaaacgc cctaatgaag ctgctacaat accctttcca 3398821 agtgaggata caactccccc ggttacaaaa atatatttcg tcatttcgtt tgctcctctc 3398881 ttcgctctta gctacatttt taaaatgtac tattttataa aaaatcattt agccttttaa 3398941 atgatttata agaaaaatga ggggtgaaaa taagaaagct ccctttcaat ttcttgaaag 3399001 ggagcataac gtactatgtt ctctcttcgt ttttgaagag cccaaaatac atactacata 3399061 gttcgactat gaaagtcaag atcgttttga agatgaaatc tgatactatt taatttcctc 3399121 ttcttcatca tcatagtctt catcatcttc atcaataata tcttcttcga tctcaagatc 3399181 atcgtcgtct tcatcaagat cttcttcgtc aaaatcgtcg gcttcaagat cgagttcttc 3399241 ctcaacttca tccaaatcaa ggtcgtcttc gtcgatctct tcaaactcgt caagatcaag 3399301 atcttcttcg actgctttct tcgctttttt ctttttcgcc ttgactgtcg gctgagtttc 3399361 ttcatcaagc tgatcataag gataccagct gcgaagcccc cacgtctggt cagaaagcgc 3399421 caggaagcgg ccgtcaatgt ttaaatctgt ataaaattga gcaatgcggt ctccaagctc 3399481 ttcttttttc acgccgagca aagatgcgat ttcatttaaa agctcctgaa aaggaactgg 3399541 ttttttatgt tcttcaaata attcgtgagc gatttcaact aaagccattt cctttagctc 3399601 ttcctgtgaa tattgtttga tacccaaggt cggacactcc ctttctatta cttatatgta 3399661 tctgttttat caataatgaa agcgattttg tatcgttctt atacaaacca tacctctcat 3399721 tataaacaaa ataaaacaga atatgctacc cttaacagcg ttaatttaaa taattttaca 3399781 agagtgatcc gactgagaga tgttttccgt taatccgcga gcattctgga gatgaccagt 3399841 ctttgaattt cttgagtgcc ttcatagatt tgcgtgattt ttgcatcacg catatagcgt 3399901 tctaccggat aatcttttgt atagccgtag ccgccgaaaa tctgcacggc ttcggtcgtt 3399961 accttcatcg ccgtatcccc agccatcagt ttggacatgg cggaagcttt tccatatgga 3400021 aggcccgatg attctaacca tgcagcctga taggtcagta gccttgaagc ttctatcatt 3400081 gtcgccatat ccgcgagttt aaaagcgatg ccctgctgct cggcgatcga ttttccgaat 3400141 tgctttcgct cttttgcata ttgaagcgcc gcatcaagcg ctccttgggc gatgcctaca 3400201 gcttgtgcag ctatgccgtt tctgcctccg tcaagcgtct tcatcgcgat tttgaagcct 3400261 tctccttctt ctccgagacg ctttgatgcg ggcactacac aatcttcgaa catgatttcc 3400321 gttgtcggtg aagaacggat gcccagcttc ttttctttct tgcctgtaaa aaatccttca 3400381 aaatcctttt ctactataaa agcggtaacg ccttttttct ttttctcggg atcggtgacg 3400441 gcaaaaacaa tgtaaatatc agcaacgccg ccgtttgtga taaacacttt ggaaccattt 3400501 aacacatagt catcgccgat tcgttcagca gttgttttca tgctgccggc gtcagagcca 3400561 gaccctgctt cggtcaaagc gaatgcgccg attttctctc cgagagccag ctgtgttaag 3400621 tactctgtct tctgttcctc tgtcccaaag gcaaacagcg gccagctgca aagagagata 3400681 tgggcggaaa gcgtcacacc ggtggaggcg cacacttttg acagctcttc caccgcgatg 3400741 acgtaggcta aatagtcact tccaattccg ccgtaatctt caggccatgg aattcccgtc 3400801 aggcccagat ttgccatttc ccgaaacagc tcgcgatcga agcgttcttg ttcgtcccgt 3400861 tcagccgctg tcggggccac ctcatgcttc gcaaaatcgc gcaccaattt tcgtatcatc 3400921 tcatgttctt ctgataatga aaaattcatt gcttctcccc cattttcaga tcagcgccta 3400981 aaacggattg agccagaagc tcgacgacgt cgtacgtttt gacttggtct tcggcttcct 3401041 tcgcctttgt gccgtcccca agcatcgtga gacaatacgg acagccagaa ctgatcaccg 3401101 atgggttgac tgcgagcgct tgctctgtcc tggcgacgtt aatcctgttg cctgtttctt 3401161 cctccatcca cattaatccc ccgccggctc cgcagcacat gccggtttcc cggcttctct 3401221 ccatttcaac aagctgcacg cccggaatgg ctttcaaaat ctctctcggc ggatcataga 3401281 cttcattgta ccggcccaaa tagcacgaat catggaaggt aatcgtctca tgaagcgggt 3401341 gctgcggtct taattttccg tttttcacaa gctcggccag cacttctgta tgatgataaa 3401401 cctcgccttc aaatccgaaa tccggatatt cgtttttaaa taaattgtat gcatggggat 3401461 cgatcgtaac gatttttttg acatcatttt tttcaaattc agaaatattc ttctcagcca 3401521 gctcttggaa caaaaattca tttccgaggc ggcgcggcgt gtctcctgaa tttttttctt 3401581 tattgccgag aatcgcgaag gacacgcccg cgtgattgag cagcttggca aaggaaattg 3401641 cgattttctg gcttctgttg tcgtaagacc ccatggagcc tacccagaaa aggtactcaa 3401701 attcttttcc ttcttttttc atttctttta cagtcggaat ctcagcatcc ggcgcctcgt 3401761 cacgccaatt ttcacgttcc ttgcggttga gtccccacgg attcccttgc cgctcaatac 3401821 ttgtcattgc gcgctgggcg tcactgtcca tttttccttc tgtcagtacg aggtagcggc 3401881 ggaggtcgat gattttatcc acgtgctcat tcatgaccgg gcattgatcc tcacagttcc 3401941 ggcaagtggt gcatgcccaa atttcttcct ctgtgatgac gtcgccgatc aagcttggat 3402001 tgtaatcaag cgccgctgcg gcttcctgcg atccgctgcc cgctgacgcc gcagccagct 3402061 gattgcctct cgtatgccga aacgctgctg cgggcaccca tggggagcgc gaggtgacgg 3402121 cagcgccttt ttccgtgaga tggtctctga gacgcaaaat caagtccatc ggagaaagca 3402181 tttttccggt gcctgttgca ggacacatat tggtacagcg gccgcactcg acacacgcgt 3402241 atagatcaag cagctgagac tgtctgaaat cctcaatttt tcccgctccg tagctttctt 3402301 tcgtttcgtc ggtaaaatca attttttcaa gttttccggc agattccatt cgattgaaaa 3402361 agacgtttgc cgggccggcg attaaatggg catgctttga ctgaggcacg tacactaaaa 3402421 agctaagcaa gaataggaga tggatccacc atgcgatata gaaaatcacc gccgcgcctg 3402481 ttttcccgac accgctaagc ataaacgcaa tacctgaggc aattggctcg ctccaagaaa 3402541 gcccatgctc atgccaaatc agattcatcc cgttcccaag cagaacggtc agcattaatc 3402601 ctccgataaa aatgagaacg agtccggctt tgaaaccgcg tttcagcctc acgagctttt 3402661 cgatataacg tctgtagaat gcccacccaa cagcaattaa aatgagaaac gtaacaattt 3402721 cctgaaaaaa ggtgaaggcg ggatagaccg ggccaagcga cagattccgg ccgggagcca 3402781 gtcctttgat gataaagtca attgctccga actgaaccaa tataaatccg tagaaaaaca 3402841 tgacgtgaat gattccgctt ttcttgtcct tgagcagttt tttctgtccg aatacattca 3402901 cccatatggc gtgaagccgt tccttgaacc gttgatcaaa ttgttctttc tggccgagct 3402961 tgatgtaggc cagtctcgtt ttgaccaagt aaacaaacaa atagacagcg taagcggtta 3403021 caatcagaaa taataatgca tttgcgatga gaaagccgct cattccaatt cccccttttt 3403081 actgataaag accgcgatcc cctacccccg aatctgtata agattatctt tatgataaat 3403141 aatgaatgag tgttcagtca ataattaaat tcctgctgtt cgggcacact acctttacta 3403201 cggaaaggag tgccggtatg aaggtattta tcgtgattat gatcattgtc gttattttct 3403261 ttgccttgat tctgcttgat atcttcatgg gccgtgccgg atacagaaaa aaggcgtacg 3403321 agcctgtttt ttcaaaaaag aagagtgaca tcgaattgat ccactgcggc gctgatctcg 3403381 ttgagcggat gatgaatgat attcgccagg ccgcctcttc tgttcacatg atgtttttta 3403441 ttatgaaaaa tgatgaggtc agccacaata tgtatacctt gctgaaaaca aaagcccaag 3403501 ctggcgtatc cgtttatttg cttctggatt gggcgggctg ccgggcaatt aaaaaaacgg 3403561 cgcttcagac gatgaaaaat gccggcgtcc atgtccatgt gatgaatcgt ccccgttttc 3403621 cttttttctt ttttcacatg caaaaacgga atcaccggaa gattacggtg atagacggaa 3403681 aaatcggtta tatcggcggg tttaatatcg ccgaagaata tcttggaaag aaggcgaagt 3403741 tcggcaattg ggaggattat catctgcgca tgatcggaga aggcgtacat gatcttcaaa 3403801 cgctttttgc ttctgatcta aaacgaaata ccggaatcga actgggttcg gatgtttggc 3403861 caaagcttca gcaagggact atttctcaca agatctatgc gaccgacggt tattcccttg 3403921 aaaacatata cttggccaac attgcccaag cgaagaatcg ccttacggtt tgcacgcctt 3403981 attacattcc atcaaaaccg cttcaagagg cccttattaa cgcaagaaaa aacggcgtat 3404041 ccgtgagaat cattgtaccg atgaaatcag accatccgct ggtacgagaa gcggctttta 3404101 cgtattattc ggagctcttg gatgccggct gtcttattta tcgttattat caagggtttt 3404161 atcatgtaaa agccctcatc atagacgacc atctcagcat tatcggaaca gccaacttcg 3404221 ataaacggag cctgttctta aatgaagagg tgaatgttga aattgatgac gaagcgttta 3404281 caagtgaagt ctatgccaca attgaggagg atatgaaaaa gtcggagctg ctgacgatgg 3404341 aggatttcag caagcgcaca ttcaggcagc gcccggcgga atggctcggc agggcattat 3404401 cttatttctt ataaaggaga gttcctatga ttttcagatt cgggttcgtt tcaaatgcga 3404461 tgagcctttg ggatgcgtct cccgctaaaa cattgacatt cgcgcgttat tcaaagcttt 3404521 caaagactga aagaaaagaa gcgcttctga ctgtgacaaa agccaatttg cgcaatacga 3404581 tgagaaccct tcactatatc atcggccacg gcattccttt gtaccgtttt tccagttcga 3404641 ttgtgccgct ggctacgcat cccgacgtga tgtgggattt tgtaacaccg tttcaaaaag 3404701 agtttcggga gattggagag cttgttaaaa cccatcaact gcgaacaagc tttcatccaa 3404761 atcaattcac tctgtttacg agcccgaagg aatccgtcac aaaaaatgcg gtaacagata 3404821 tggcgtatca ctaccgcatg cttgaggcca tgggcattgc tgatcgctcc gttatcaaca 3404881 ttcatattgg cggcgcttac ggaaataaag acaccgccac tgcacaattt catcaaaata 3404941 taaaacagct gccgcaggag atcaaagagc ggatgacact tgaaaatgat gataaaacat 3405001 atacaacgga agaaacgctt caggtctgtg agcaggagga tgttccgttt gtctttgact 3405061 ttcatcattt ttacgccaat ccagacgatc acgccgacct gaatgtagca ctgccccgca 3405121 tgatcaaaac gtgggagcgg atcggccttc agccaaaggt tcacttgtct tccccaaaat 3405181 cggagcaagc gatacgcagc cacgccgatt atgttgacgc caactttttg ctgccactgt 3405241 tggaacgctt taggcaatgg ggaactaata ttgatttcat gattgaagca aagcagaaag 3405301 acaaggcgct tctccgcttg atggatgaat taagctccat ccgcggtgtc aaacgcatcg 3405361 ggggcggtgc gctgcaatgg aagtcataaa tgtgcaaaaa taggtttacg acttgtcagc 3405421 tttgggaact taggctatat aagacaacaa tcgatggagg agaaagatca tgaaaaatat 3405481 caagtctctg aaagtagccg cacaggcctt tactttaaga aatttgattc atctttataa 3405541 aatgtgccat tccggaagcc acgaggttta tatttattca aagaaaacga tgtgcaaaat 3405601 caaaagctta attgagcttg aaacgttccg catggctcat aatgaaaagg aatatctgat 3405661 cgtagttgaa ggaacaaaag catcacagct cattgaaaaa ttccaaaatc tcatcgagcc 3405721 tgctgagaga gaagcgctct aacttacata caaaaaagga tagacatctg tctatccttt 3405781 ttcttatgct cttacataat ggagctgaac cgcttgtcca aattgttttg tcccttttaa 3405841 ccgcagtttt gtttcatttg ttagttcgtg aaacagcggg atgccgcttc ctaaaacgac 3405901 gggaataaca gtgatgatga attcgtcgat ggcatcttct ttcataaagt cattcacaag 3405961 ctctgccccg ccagctatcc agatgtttga gcctttttcc tgtttcaaac gggcagtgaa 3406021 ggctctggct ccctcattga taaacgtcac atgttcatct tgataactgt cgggcgatcc 3406081 tgtaaaaaca tagcaggttt tatcctgata cgggaaaacc ggtgttagca ctttaacgtg 3406141 ctcatatgtg ctccgcccta aaatgactgt atcaacagtc tgataaaaat cactgtagcc 3406201 gttgtcacct tcaccttcaa attcatccag ccaatcgatg cttccatctt cttttgcgat 3406261 catcccgtcc aatgaaacag caatgtacag cacagttttt ctttccatgt tctcctccta 3406321 tcgatgcacc atttgcccga attgcgcttg atgcagcctg ctgtataggc ctccggcttc 3406381 gatcaggtct tgatgacggc cttgttcttc aataccgttg tttgtgacga ctacaattct 3406441 gtccgcgtct ttgattgttg ccagcctgtg ggcgatgaca agcgtcgtgc gcccctcaga 3406501 caactcttga agcgcctttt ggatcgccgc ttccgtctct gtatcaaggg ctgaggtggc 3406561 ttcgtcgaga atcaagatcg acggattttt caagaacatc cttgcaattg acagacgctg 3406621 tttttgcccg ccggaaagct tcacgccgcg ttcgccaatc atagtatcca acccatcggg 3406681 catgttatgg acgagctctt ccagatgcgc ctgcttcaca gcttgccaaa tgtcttcttc 3406741 tgatgcgcct agtcggccgt aggcgatatt ttctctaagc gtgcccgaga ataagaaaac 3406801 gtcctgctgc acgacgccaa tctgcccgcg caacgaagaa agcgtcatgt cttttatact 3406861 gatgccgtca atcgtaatgt cgccctccga tgcttcataa aaacgcggaa gcagactgca 3406921 aagcgttgat ttcccagcac ctgacggacc gacgaacgcc accgtttccc ccgcttgaat 3406981 ggataggttg atgtcattga ggacattgtg atggtcatca tagccaaacg aaacatgttt 3407041 atagcggata ttgcccttca ggccggaaac atctttcgaa tcaggtgagt cctgaatatc 3407101 cggctctgtc tccatgagct ccatatagct tttgaaaccc gcgatccccc tcggatacat 3407161 ttcgataatg gcattaattt tgtcaatagg cctgaacagc acattcgtca agagtacaaa 3407221 cgccacaaat tccccgtacg ataaggagcc gcgaatgaca aaccacgtcc cgcacaaaag 3407281 gacaaacagc gtgacaaacc gggtcagcat atagctgatt gaaccgtttt tcgccatgat 3407341 tttgtaggaa gaaagctttg tgacacgaaa acgctggttg ttgacggcga agcgttcttt 3407401 ttcaaatgct tcatttccga acgcctgcac aagccggatg ccgccgatgt tattttctac 3407461 acgcgcgctg aagtctccga tatccttgtt cagcgtggta aatgctttgg tcattttttt 3407521 gttgaaataa agcgctagcc aaatgacgat cggcataatg ataaacgtta ataaagcaag 3407581 ctgccagtta ataaacagca tcactccgaa cgccccgaga atggtcatga ccgcaatgaa 3407641 taagtcttcc ggtccgtgat gggcgacttc accgatatac attaaatcgt tcgtgagctt 3407701 cgacatcagc gttcccgtct tgttgttgtc gtaaaatttg aacgagagct tttgcaaatg 3407761 gtcaaaaagc gactttctca tatcagtctc aatattgata ccaagcatgt gtccccagta 3407821 ggtcacgata tactgaagag ccgagctgag cgcgtacacc gcaaataacc cgattgaggt 3407881 cgcgatgatc agtccccagt ccctgcccgg cagcaaggta tcaataaaat aattgacgat 3407941 caaaggaaaa ctcagctcca ttaaacctcc cgcgatcgct gagaaaaagt cgagaaagaa 3408001 caacgtttta tatggtttat aatatgaaaa aaattgccgc agcaccctat cttcccccaa 3408061 tgtataaata actgataata tttctcaatt atactataca cgggctgttt tgtaagatca 3408121 gatttctttt ttcttacaga acacctgaaa acaggcgggc aaacgactct tttgtccggt 3408181 cagccacacc tcttttataa aagccgacag ggctgagctt ttcactttcc tgcatatcct 3408241 cttcaaaatg ggcctcaagg gttcggatcg cttcggcatc cgtgaagaac acattcactt 3408301 caaagttgag ctgaaagctg cgcatgtcca tattcgcggt accgacggag gcgagatcgc 3408361 catcaatgat catgactttt tgatgcatga agcctttttg gtaggagtac acttcaatgc 3408421 cctcaaggag cagctccggg aaataggacc tcgacgcgta ttgggtcaaa aagctgtcgt 3408481 tcttctccgg caccataacc cttacctcta ccccctttgt cgccgctgct tttagcgccg 3408541 tgcgaatgga ttcattgggg acaaaatagg gcgtggcgat ccatattgat ttctgcgctg 3408601 aagaaatcat ttcataataa aggtcgctca tgctttcctt catgtcaggg cctgtcgcga 3408661 caatttgata aatgcctcct ccttccacgg gaaccggggt attgtactcc tcttgatcaa 3408721 ttagcacttc attggagaca tattcccaat ccagcataaa gatagcgtgg agcgtttgca 3408781 caatttcccc ctcaagccgc aggtgtgtat ctctccaaaa tccgatgtac ggatctctgc 3408841 tgatatattc cttcccgaca tttaatccac ccacaaaacc ggttttccca tcgatgatca 3408901 cgattttccg gtgatttctg aaattcagct tctggttgaa aaacccgtat ttcagcggag 3408961 aaaacgggac gatgtccacc cccgcttgtt tcattctcat aatatctctt cttgccagct 3409021 tcatgcttcc tgccgcatcg tataaaaacc tcacctcgac accctggcgc gctttctcca 3409081 tcataatatc catcatgccg cgtccgagca tgtctgattt aaacatgtag tattcaatat 3409141 gtatgtaaga ttccgctttt ctcattgctt tgaaaatgtc cgggaaggtt tcttcgccgt 3409201 ttttcagcac tttgatgttg cttttcgtat tgatattcat atgggcagcc ctgatggaat 3409261 atgtaaagaa cctctcttga ttgtccttca gccctgtcac ttcgggcgtt tcctccttgt 3409321 caaacagctt cctgagcttt tccctgttgt acattcgttt tgtcttaaac agctttccct 3409381 ttacataaag ctgtcccgaa aacagataaa acacgtagcc gacgattgga aaaaagacaa 3409441 gaatatggat ccatagcagc gtgtgctgcg aggtgcggtt ttcaagaatt aatgaataga 3409501 tgctgaacaa aataatgctt atatagcaaa gcaatcctcc gtaaaactca agtctggaaa 3409561 ccggaaaaaa ccaaatgaca tatgccccga tgagcatcat atataaaaag aaaaattcca 3409621 gtctcctttt cagcatcctg attctctcca atctgattca attacctctg tattacctct 3409681 tttttctaat cgataaacct tgtaagtaaa aaacctctcc gccaaaggag gagaggttta 3409741 gagaaaacta actgtcacgg aattcatccg catcgtttct gcagaaataa agcaagacta 3409801 ttggcaacgc cgagtgacaa catgagcggc aagctgaacc cgctcagcac tccggcaagc 3409861 gccgaaaaga aggcggcgct gtgactgcaa atacggtgga tagagtaaat ttgataccca 3409921 ttctgatgag agaaaatata taaaacggga aattgatcag aaagatataa ggagttagtc 3409981 aggctgaatc ataatctggc tgttccgccg gtttaaaatg agtaaaatcc ttgatgttat 3410041 ttccatatac aaacataaca ggattcccgg cagcccagcc attaccttgg cagaaaaaac 3410101 cccctcttgc aagggggatt ttcacgagcg tttccgatat acaacgtagc tgcgggtcag 3410161 atacttgagc ggcagactga acacatgaac caatctcgta aacggccaca ggataaaaac 3410221 gacgtatcct atcacaatat gaaacttaaa ccatagcggg acactctcca tcaaagaggc 3410281 gtcaggcctg aacaaaacga tttccctgaa ccagggcccg actgtggtcc ggtaatcaaa 3410341 tcctttcgaa tcaatgttga gaaacgtggc cgcaacgcct gacagcatca tgaacagcag 3410401 caggaggagc gtaaggatat cggatggcga gctcgttttg cggattcttt tgtcaaacag 3410461 ccttctgtac gtcaggatga caagtccggt acatgccgca atgcccgccg gcaagccagc 3410521 gccaatcgcc attttgtgat acatatgctc tgaaatgcca agggaagcat acacgccttc 3410581 tgggatcaga atccccatga catgcccgcc gacaacgcac agcagtcccc agtgaaaaag 3410641 tgtgctgcca gccgcaagtt ttttcttttc taacagctcg cttgatttcg ccgtccagcc 3410701 aaattggtca tgctgatagc ggtaaatatg gccgccgata aagattgtca atacaatgta 3410761 tggcataata ccccagagga tctgcccgct catgcctgaa cagccccttc aacgctttca 3410821 cgtacgccaa tgttttcaag cgcggccagc agcacgtgca gcagttcagc gtatatactg 3410881 tcattttttt cgagacggga tgccagctcc ctcacattgg acagatattt ctcaaacacg 3410941 cttctcgctg cttcaatttc tgcagccgca gcaaattcca gcatcagcgg cagataatca 3411001 ggcagctctt tctctgtcgg caggaaaccg gattgctcgt atgtgttttt taaatgcagc 3411061 aattcaatgc cgcgttccct ttgctcgcct gagttaaagt aggtgacata catatttgtt 3411121 tttttcccga agtcgaatgt atagacatag tgttcaatca gcgcttccgg agaatagctg 3411181 gctgacgtct cgaaaaagtg cagcagcttc tcccggattt gccggttgcc gatttcttgg 3411241 ataagagcct tccaatcggg aagctcggct ctccactctt catccggata agagagaaga 3411301 caggaaagag cagagaacgt gatttgccgg tctgtggtgt tcatcttgtt acacctcatt 3411361 tatcaaaagt tagaaacagg agccggggcc gcctgaaaat gataagccgc agcttccttg 3411421 ttcagcgtat aaatctgata cttcttctcg atggctgctc ggaatcacaa agcggtcatc 3411481 atatttggca atcgcaagca gccgatacat atcttcaatt tgctgttctg ttaagccgac 3411541 actggagatc agttccggat cgattgattt attcgtctgg accgctctca tatactggcg 3411601 catgacagac attttcttta atgttgaccg aatatgatcc gtatcaccgg ctgttaacag 3411661 ctgcgccaaa taatctatcg ggattctcat ttggtcgata gccggaaaaa tatcttccgc 3411721 cgtttgccgg ctgccttttc cttcaaagag attcataatc gggctgagcg gcggaatgta 3411781 ccacaccatt ggcagcgtgc ggtactcagg atgaagcggc agcgcgatct tccagtcaat 3411841 gatcatttta tagatcggtg attgctgcgc ggcctctatc cattcagccg gaatgccttg 3411901 ttcttttgcc agtttggcaa cctcaggatc attcggatca agaaaaacgt ccaattggga 3411961 atggtagaga tccttttcat tttcaacaga tgccgcttcc tccactttgt ccgcgtcata 3412021 tagcatgacg ccgaggtagc ggattctgcc aacacacgtc tcagagcaga tggttggcag 3412081 tcccgcctcc aaacgcggaa agcagagtgt gcatttttcc gctttgttcg tttgccagtt 3412141 aaaatagact tttttataag gacaggatga gacgcaatat ctccatgaac ggcatgcgtt 3412201 ttgatccaca agcacaatgc cgtcctcctc gcgtttgtac atggcgccgg atggacagga 3412261 tgagacgcat gccgggttga tgcagtgctc gcaaatacgg ggcaaataca tcataaagac 3412321 gtcatcgaat tctgttttga tcgattcctc catcttttgt acgttgggat cttcaagtcc 3412381 cgtaatgtgg ccgcctgcga gatcgtcctc ccagttcggt ccccattcga tattcatgaa 3412441 atcccccgtc aaggacgatt tcgggcgtgc taccggctgg tgttttttct gcgggctgtt 3412501 cgttaatgtt tcataatcat agttccaagg ttcatagtaa tcatcaattg acggctgatt 3412561 cggattatag aaaaggcctg caagccgatt ggttttcgag cccgatttca gctcgagctt 3412621 tccttttttc aatgtccagc cgcctttata tttgtcctgg tcctcccatt gcttcgggta 3412681 gccgatgccc ggctttgttt ctacattatt gaagtacata tattccgcac cggaacggtt 3412741 tgtccacgtg tttttgcagg tgacgctgca cgtgtggcag ccgatgcatt tatccaagtt 3412801 catgaccata ccgatttgcg ctttaatctt caagccaatc gacctccttc agcttgcgga 3412861 tgacgacgtt caggtcgcgc tgattccccg ttggaccgta ataattaaag ccgtagctga 3412921 gctgggcgta gccaccgatc atctgtgtcg gcttgacgtg aatccttgtc gggctgttat 3412981 gggtgcctcc gcggttattc gtcagctttg tgccgggcac gttgatgtgg cggtcctggg 3413041 catggtgcat aaacgccatt cctttaggaa tccgatgaga caaaacggct ctcgcgacga 3413101 caacgccgtt tcggttgaag cattcaatcc aatcgttgtc tttgatatcc gtgtcctctg 3413161 catcatcttt attcatccac acggtcggcc cgccgcggaa cagcgtcagc atcggcagag 3413221 aatcaaaata catgctgtgg acagaccatt tattatgcgg cgtcaaataa ttgaggacga 3413281 tttcttttcc ctcttgatca ggccgtttgc tcagaaacgg gcgatgctgg aggatcggtt 3413341 tgaatgtcgc catcgtttca ccgaattcca tcatcagttc atgatcgaca taataggatt 3413401 gtctgcctgt cagcgtccgc cacggaatta atttttcaac attcgttgta aacggcgaat 3413461 acctgcgccc tcctttttca gagccggtaa acgctggaga cgtgatcacc gttttcggct 3413521 gggctgtaat ttgttcgaac gtaaagcatt cttcctcgcg ttcttccgcc aggtctttca 3413581 gcttcaggtt cgtgatgttt tcaagtgatt cccatgcttt tactgcgacc tttccattcg 3413641 aagtggatga tagggttaaa atcgcttctg cagcctgctt tgcttcactt atatttggac 3413701 atccctttgc cacgctgtcc gaggtgattt ctcccagtct ctgtttgagt gattcatatt 3413761 catcggctat tgaccagctc atcccttttg ttccgctcgg ctttaaagca acgttcggac 3413821 caagtgcagt cattttatga aaaatgtgtt tgtaatcccg ttcaacgact tggatgttcg 3413881 gcatcgtttt tcccggaatg gcttcacatt cgcctttgct ccagtcattg attttgccga 3413941 atggctgggc caattcctgc atggtgtcgt ggagcagcgg tgtcgcaacc acttctttca 3414001 ccggctccat atcgacttct tctgccagat cggaaacggc ttttgacagc gccttgaaaa 3414061 tatcccagtc tgacttcgat tcccacggag ccgagatcgc aggagcaaat ggatgaatga 3414121 acggatgcat atctgtgctg ctgagatcgt gtttttcata ccatgtcgcc gccggcagca 3414181 cgatatcgga atacagcgcc gtacccgcca ttcgaaaatc aagattgatt aataagtcga 3414241 gctttccttc cggcgcctgc tcccgccatt tgatttcttc tgggcggatg ctgtcgctgt 3414301 cgtcattcat taaaccgttc gttgtcccca gcaaatgctt gagaaaatat tcatgccctt 3414361 ttcctgagct tgagatcaga tttgcccgcc atacaaagag attccttggg aaattcactt 3414421 cattgtcagg atcttcaatc gcgaatttca gttttttctc ttggagctgt gaggccacgt 3414481 acgcacctac gtcttcaggt gttgctgccc ctgctttttc agcttcttta tacagatcga 3414541 tgccattttg attgaaagtc gggtaagacg gaagccaccc tagccgcgcc gccagcacat 3414601 tgtaatcagc gtggtgcttg tagcgggatg aagcagcaat cggtgatgcc aaatcactga 3414661 tcggctggtc ctcataacgc cactgatctg tcgcaaagta gaaaaatgag gtgccatttt 3414721 gcagcttggg cacgccttcc cagtcctttg cagttgcaat cgtctgccac ccttcagcag 3414781 gtcggagctt ttcctgcccc acgtaatggg cccagcctcc gccgtttacg ccttgggcgc 3414841 ctacaagtaa aacaagattt aacactgctc ggtagatcgt gtcggagttg aaccagtggt 3414901 taatgccggc ccctacgata atcatggacc ggccgtctgt atcgatcgca ttttgggcaa 3414961 actctctggc aatcttaacg acagcttctt ttttgattcc tgtcatttgt tcctgccagg 3415021 caggcgtaaa cggctcaggg tcatcatagg agacagccga tcgttcgccg atgccccggt 3415081 tcacgccgta gttagccagt atcaagtcaa acacggtcgt gatgtacgtt tcttcaccgt 3415141 tcaggttcat ttttttaata ggaagatccc gctcgagcac tttgtttccg tcatttgaaa 3415201 aatacgggat gcgcaccgtg ccgatttcgt cctctattcc cagcacagag agacggggtt 3415261 caatcggttc cccggtttct tcatcaatca tgtgcaggtt ccatttctgc tgcccgtccc 3415321 agcgcgagcc cattgtccct tggggtatgg caaatgaact tgtctgttca tcccaaaccg 3415381 caggcttcca ctgatcatgc tttgtcttcc gcccgatgtc cttcgcatgc agaaaccgtc 3415441 ccgctgtgta tacgccattt tcttttgaca gagtgacgag aaatggaaaa tcagtgtatt 3415501 gcttcgcgta ctcaataaaa cgttcagttt cttggttcac gtaaaattcc tgcagaataa 3415561 cgtgacccat cgccatcgca agcgccccgt cagtcccttg gcgaatactc agccagtcat 3415621 ccgcgaactt tgaggattcc gcaaaatctg gactgatcga aatgacctta gcgcctttat 3415681 agcgggcctc cgccaaaaaa tgcgcgtcag gcgttctcgt taacggaacg ttggagcccc 3415741 atgtgataat atagccggaa ttgtaccaat cactgctttc cggaacgtcc gtctggtcac 3415801 cccaaatttg cggggatgct ggaggaagat ccgcatacca gtcataaaaa ctgagcatag 3415861 ggcctccgat taacgacata aaccgggagc ctgatgcgtg gctgatcatg gacatggccg 3415921 gaatcggaga aaaaccgacg tttcggtcag gcccgtattt catcactgta tacagcagag 3415981 aggctgaaat cagcttcagc acctccggcc attcagcgcg cacaaaaccg cctttccctc 3416041 tcgcctgttt ataggacttc gctttttcag ggttttcgac gatcgatttc caggcttcca 3416101 atggattttg atgcgtctgc aatgcctccc gccacaaatt gatcagcaca ccgcgcacgt 3416161 atggatattt cacacggagc gggctgtaga tataccatga aaaactggcc ccccgcgggc 3416221 agcctctcgg ttcaaaatca ggcatatccg ggcctgttga tggataattc aaattttgcc 3416281 cttcccacgt gactattccg tttttcacat aaatattcca gctgcaagac cctgtacagt 3416341 tgacgccgtg ggtggagcga acgactttgt cgtactgcca tctgtttctg tatacattct 3416401 cccaatcgcg atcctcgcgg gtagtttggc tatgtttatt tgaatggtgt tcgataggag 3416461 agaaataatt caatctccta aacaacggac tccttttctt tttcttcatg agagttcact 3416521 ccttccgagt caggtgatgc taagttcact ataaacagag acagcgtgtt tccttgtgaa 3416581 ctatgtcaca cactctgctt ttttcacaaa atgttcacac aaaggagaag gaaggctgcg 3416641 ttcaggcagg acgcttgggt cattagctgc ctttcattca aagatcaaaa aaaaccggct 3416701 ctatttaaga accgggctca gcgttttcat cctgtgatgt atgcagatac cgcaaaaata 3416761 attgatagga acaaaaaaca ttttgctgaa gcatagccaa aaagttcatt tgcagctgcg 3416821 gatgataaga catcattttc ttaaatatgt aatatgggat gttgagaatc agaatgtctg 3416881 aagtggcatt gactgagata aagggcgata aataaagccc gcctttttca tcaatcggaa 3416941 acacatcgcc tttttcccac agcgcaacgg ttttcgaccc ttcagggagc cttgtgtcca 3417001 taaaacggac actgcctttt aatacaatat aaacagattg agaatgaaga aaagatggag 3417061 actgatcaca tgaaccgcgg ataaacgtgc cgtttttcag caaggtttcg acaatggata 3417121 gaggcacttc attaaacata ggaagttgtt tcagaaataa taaatagtca cactgattca 3417181 taggaaaacc tcctgtgcta aggatagctt tagtgtagct cgactgagcc tgtacagcag 3417241 tgatgtattt cacagcctgt atgatgaatg tcacttatca ggagggtgaa tgcatttata 3417301 atgaaagaaa aaaggaggat ttcgatgaag gcgctgattc cgaagcagca cggggcgtgg 3417361 gcgatgctgc tgatcccatt tttactcggc atggtcaagg gaggccccgt tatttggcat 3417421 attccgctct tccttggttg gcttttccta tacttagcgg tttatcccgt tacgcttgcc 3417481 ttaaaaaaga aacaaagcaa accatatcaa aagtggatgt gttattacgg ttttcccacc 3417541 tgctgctttt tgatgatctc ggtctttcat aagccgcctc tcatctgggt gggcgtttct 3417601 ttactgccgc tgtttctcat acatatgtat tttgcccgca gaaaaaacga acgagcctta 3417661 ttgaatgatg ttgcaggtgt cttgttcttt tgttcgggcg ggtttgcgag ctgctggctg 3417721 gggatgggaa cccttgacgg ctgggcttgg tttattttct tgcagtctgc tttatttttt 3417781 atcgggagtt ccttttatgt gaaatcggtg atccgcgaga gaaaaaacag ggcatttgca 3417841 tactggtcat ggggatatca cctgctgctc ccctttttat ccgctctttt cggagcagga 3417901 tgggcgtttc tcgcttttat cccgagcagc ttgcgggcat ggttttttca tggaagggat 3417961 tggcccgtaa aaacgattgg cattctggaa atcgtgaatg cctgcttctt tcttgccgtc 3418021 atgtgcctgt ttatcacaag gtaaaaaaac aaggacaccg ctgtccttgt ttttttcagt 3418081 caatattgca aatctccagc gggcaatttt cacactcaat ctcacatcgt aaatagtccc 3418141 gcttgtgcaa aataattttt ccggattcgt ctatcgaaat aacccctttt ttgcggagat 3418201 ctccgagcat acgattgacg ctttcccgtg cagccgcgca aaactttgcc aaatcctgat 3418261 ttgtcaggac aatgttaatc agaatgccgt cgcttcgctc cactccgtag ctgtttgata 3418321 agcggataag ggtagaatag agcgccccct ttttgccatg aagaagcaga tccctgattt 3418381 tggactgaat cttccggagg tgcgtgctca tccatttcat gaactcaaat gtcaaagcgc 3418441 cgttttggat taattctttt tccagcttat ttttattaat gacgagcacc tcgccatcct 3418501 ctagtacttt tgcactgagc atataccttg gttcttcagt gaaaagtgtt aattctccga 3418561 cgatatcatg cttttggcag attctaagcg tcaggtcttt tccgtcagat gtcagcttgc 3418621 cgatttcaat gagtcctgat tgaatcagat aaagctcttc tgcatccatt ccttcccgaa 3418681 acaaatacgt gtgtttttcc atttttcttt tcgtgctgat cgattccagc aattcataca 3418741 gatcgctgga tataagatca ctatcagatg gtcgaacaga gagaaaattc atgagctcac 3418801 ctcgaagaaa gtcacgttgt gtgtttattg taacgtgaat tgatttgtac ccatcgagaa 3418861 aaaactaaca atcttgtgaa tgccccagtg ttagttgatg ctctggctgt ttctctccgt 3418921 gtgtgttttc attctttcct gccaatacat ccatatgaca aggacaaaac tggctaacgc 3418981 cacctctgaa agcgccataa acccgatcgc gtactggcct gttgcctgaa atacactcgc 3419041 caatatgagc ggaggaaaaa agccgcctaa accgcccatg gcagacacaa tcccattggc 3419101 aatccccgct tgcttcgaaa aatagaaagg caccagttta aaaacagttc cgtttcctat 3419161 gcctgagcag acggccacgg ttaatgatcc aaacgtataa aggccgattg tcggcgagaa 3419221 cgataggata atgcctgata atgtaagccc ggcaaaaaca aacatcaaga tgcggagcgg 3419281 gctcatttta tcagccagga atccgcccgc aggcctgagc agcgtagaaa ccgcaataaa 3419341 gccagccgtc cgcaagccgg catctgcagg attcagccca aaatgctcca ccagaaagtt 3419401 cggcagatag atagtgaagg cgacaaaggc accgaacgta ataaaataaa acaggctcag 3419461 aaaccatagc acatgatttc ggtaaacagc tttgatttga gtcttaacag aaactttgac 3419521 cttcttctca tgcctgtcgc caaacaatac gtgcagtaag gcaaagacag ccagcaaaat 3419581 cagatacatt tgcacggttg atttccaccc gacggcttga gcgataaccg gcgctgcaaa 3419641 tgtcgtaacg gctgtcccga tatttcctgc accgtaaatc ccattgacga caccgtgctt 3419701 ttctttcgga taatatttcg ggagggaggt caccccaatg gaaaacaccg ctcccccgat 3419761 ccctaagaaa aagccgcctg cgattaaatc aaacagagaa tccgcgatac tgatccaaaa 3419821 tacaggaaat aaaagcagga tgaagctgac cataaacatg agccgcgcgc caaacctgtt 3419881 cgttaaatac cctaaaggaa tgcggagaag cgacccgagg atcacaggaa tcgcggtcac 3419941 taaagaaatc tcacccttgc ttaaatgaat atctaatgtg atttgggaaa tgagtgatga 3420001 aatcagcacc caaaccataa accctgccac caagcttaat gactgtaacg ataattgaat 3420061 gtgttgacgg ttgatcattt ggcttgcccc tttcaatgat tcaataatca gtcttatcat 3420121 acaaaaacta gccaaacagg attgtgaatt acatcacacg tttttctcat aaaaaaagga 3420181 caaagcccga agactttgtc cttttgatcg tgattacatt ttttccggag ccgatacgcc 3420241 gatcagctga agcgcattgt tcagcgtaat ttgcgttgcc ttcattaaag ccaggcgcgc 3420301 gcggcttttc tcttcatttt cagggtcgat gactttctct gcgttgtaga agctgtgcag 3420361 agcagaagcc agatcataaa tatagttagt gacacggtgc ggaattcgtt tttccgctgc 3420421 ttccgccact gcctctggga agccgccgat cgttttcagc agatcgtatt ctttttctga 3420481 ttgaatatgg ctgaaatcaa gatctgccgc cggtttaagc ccctgctctt ccccttggcg 3420541 aagcatgctg caaatacggg catgcgcgta ttgtgcataa tacacagggt tttcgttaga 3420601 tgttgataca gcaagatcta agtcaaaatc catatgggtg tctgcacttc gcattgcaaa 3420661 gaagtaacgc acggcatcca agccgacttc ttcaatcagg tcacgcatcg ttacggcttt 3420721 accggtccgt ttgctcattt tcattttctc gccgtttttg taaaggtgaa cgagctgaat 3420781 gatttctact tcaagcgttc ctttttcata gcccagcgct tcgattgccg ctttcatacg 3420841 cgggatgtag ccgtggtgat cggcgcccca aacgttgatc agcttatcaa agccgcggtc 3420901 aagcttgtcc ttatgatacg cgatatcagg aagaaggtac gtgtacgtgc cgtccttctt 3420961 gatcaatacg cggtctttat catcgccgaa agtcgtggaa cggaaccaag tcgcgccgtc 3421021 ttcttcatag acgtggcctt tttcgcggag cgcttcaagc gccttgtcga tttttccatt 3421081 ttggtacagt gaagtttctg aataccacac atcaaacggc acacggaagt tttccaagtc 3421141 cttgcgaagc ttttccagct cgtatttcag gccgtattca cggaaaaacg cgaggcgttc 3421201 actttcctct tcgttaacga aacgatcacc gtattcctca gcgagacgct ttccgatcgc 3421261 aatgatatcc tcaccgcggt agccatcctc cggcatcggt ttttccaatc cgagtgcttc 3421321 aaagtaacgg acttcaacag aaagcgccag attgttgatt tggtttcccg catcgttaat 3421381 gtagtattcg cggcttacat cgtaacccgc ttttgaaagc acgttgcaca aggaatcgcc 3421441 gacagccgcc ccgcgcgcat gcccgaggtg aaggtctccc gtcggattcg ctgatacgaa 3421501 ttctacctga actcgttcac cgtttccgat gttcgtttcc ccgtatgctt cccctgcttc 3421561 cagtacagac ggaatcagct ttgttaaata ttgattgttc atatagaaat tgataaaacc 3421621 cgggccggcg atatccagtt tttcaatcga agccttccct ttatcaaaat gggcgacaat 3421681 ctcttcagcg atttgacgcg gcgctttttt tgccactctt gccaactgca tcgccatatt 3421741 cgttgagtag tcgccgtgtg ttttatcttt cggtgtttct aaaacaacat tgggaatctg 3421801 gctttcttca gccagtcccg ctttcagaac ggccgctttg atttcttctt tcagcacgtc 3421861 cttcatttgt tccgcaatgt tcatgcgtga gttcctccct catacgtgat cgtcatatta 3421921 tgtaaatgct cctgctcgtc tccgacatgc atgtcatatg cgatgctgat acggcctttt 3421981 tcttcatcga gatcagattg aatcgatttt gtgcttgttt tcagctcaag ctcaccaaat 3422041 gacattttat atttagcaat tgtggaagct cccgttacga aacgctgatt cattttgaca 3422101 gcgcctgacc tcatgaccag gacttcgcct tcgcttactt tcacaatcgt tttgactttg 3422161 cctaagtcgt gttcttcata ataagataga tacactttat tttgttttac atagtaaaat 3422221 ccggtggtgc ggaattcgat gacttcttgg tttccgtcat cctcgatcac agacttcaca 3422281 tggagtgtta tcggtgtctc ttgcttcatt ctgacacgtc cttttcatca ttccactttg 3422341 acttgaatag tataatcatt cggtttgtaa acttcaactg cttctatctt accatcattg 3422401 ctcatcagat ttgaagataa acctcataaa aagcatttcc ttatatagaa gagaaaatca 3422461 tatcactaat tacctttagg aaatgttacg agctcgctac atcgcaatcg cagacggacc 3422521 cgcgccaacc ggaatcaccg tcacggctgt ataatcactt gtgcggtaca cggtcacagc 3422581 attgtcgttg ggctgtgccg cataaatata ctgtttgtcc ggcgttacgg cgaggtcaaa 3422641 ggcgccgggg agagacacgt ttgcaatgat cctctgtctg gccgtattaa ctacgtataa 3422701 gttattaatg agaaacggtt cactatatgg ctctagaaaa taagctctag tactatcgag 3422761 agaaaataca atcgtcctca gcgtttcaaa taaacggctg aagtcccctc ccctgcttaa 3422821 tggtgacaaa ctaatctccg ttacaccttt cggccacagc tcaccattca atacgtacgc 3422881 aaaatttcca gcgtaaggag ttgtaattaa actgggaaat tcaaatgtat ctatgatact 3422941 ttctaccaac tgcccagtat ttacatcata tttatcaacc gaccaactgc ttccattagc 3423001 ggtatagaca tactgtccat tcggatcaag agcaaagtct aaagcgccgg gtatcggaat 3423061 gacatcaatg accgattgag aggccgtgtt aatcacatat atagatccgg cggccatcac 3423121 gtatgcgaac tcatctgttg gatcaaattc gatttttctc ggccctcctc caacagtaat 3423181 ggtatttatg atggttaatg ttttattatc aatcactgag acaaggttgg tatttccatg 3423241 gaggacatac gtgaatgctt tatcgaaagt aacgcctaga ttagttggca cgtcagaaaa 3423301 agggattgtt tttacaacag tgtttaaatc tgcatcaata accgaaaccg tgctgtctcc 3423361 agtattggca gtaaacacat acgattgagg gtctggtgat ggcggtaaaa caagtgtccc 3423421 ggccaccgta agcggactgc cgtagaaagg cggtacaatg agcagatctt ccactgttat 3423481 ttgactgaaa tcaggacagc ggccagactg tgctgcataa taaacaactt gatcaatctc 3423541 ttcagtatga atcacagaaa cagccccgtc tccttgtcca tattgatttc gtacaggcga 3423601 cacactgaca agaagcgtaa tggtcccttg tactctcaca gcatatcgaa caccgatatc 3423661 ttctggttcc ggcccagtct ggattaagca aggctcactg atacaggaca aattgtctgt 3423721 actccatgta acagccgctg acgcttcggc cgtatcaacc ttgaagccct cagggaaatc 3423781 tatcggcact tgaaacggcg cttcccggct aatttcctca tcacaaaaac agaaacaatt 3423841 ttcctgtaaa gcagaaagat cattcttttt catgatttca cgtcctttta gaaatgcaca 3423901 acatgcagcg gttaaatcgt aatggcaccc ggtgaaaccc caagagatat cacagtttcc 3423961 tcagaataat catctgtgtt gtaaacaatg atgctctgct ctataaaacg agttgcatac 3424021 agaaaatcgc cattcggggt aaacgcatag tctgttgctg attgcggaac atttcctata 3424081 acgcctgctc catttggact gacagaatat aaattgccag tgaagccgtc atataaatac 3424141 acctctgctc cactcgtaaa cattcgatat tccccttcat actccagctc ttgggtgctg 3424201 ctgatggtaa acgtatttaa atcaataacc gtcaaataat taaaaaagaa ttcttgttct 3424261 aatacatagg cataccgctc cggccaattt gtttctatgg ttgatacgat aagctctcgt 3424321 tcaattgttc ctgtgacttc accggtagtt aggtccactt tttgcactat tccaaaattc 3424381 agaacatagg cgaataaccc attgggatcg attgcaacat catatccttc cacaggaatc 3424441 gacctatcca cagttaacgt atcaattcca atcacataaa ccgcagtacc ggtgaaaaca 3424501 taagcaaact catgattagg gataaatcta atcaatcgag gcggctgatc cagcaatata 3424561 gttgctgtca ctgttaatgt gtcataatcg atgacagaaa tcacattatt gttgggatgt 3424621 aagacaaaca cagcgctttt atctggcgta atttcaatac ctgccggatt gtacggaaga 3424681 gcaatcgttg tcacaacagt atcggtgttt gtatcaatca cagaaactga ttgatcattt 3424741 ggattcgctg taaacgcgta gacgggttcc ggctccggta caagcacaat tgtccccgtc 3424801 accgataaag gactgccgta aaacggcgga acaacaacaa ggttctcaat cgtgatgtca 3424861 ctgatatccg ggcaatcatc cgattcatcg gaataataga cgacttgatc gatttctgca 3424921 ttgtgaatga cggaaacagc cccgtcccct tgtccatatt gatttcggac aggtgagaca 3424981 ctgacgagta gcgtaacggt tccctgcagg cgcactgcaa attgaacacc gacctcatca 3425041 ggctcaggcc ccgtttgaat taagcaacgg tcactgacac aagaaaggct gtctgcattc 3425101 cacgtcacgt ttgcaacagc ttcagccgga tcaacgacaa acccttcagg taattcaatc 3425161 ggtgcttgaa acatggcttc tcggcttgct tctccctcac aaaaacataa gcactcttct 3425221 tgttctgctc ctgctttttc tttaaaggaa agcttgtttt ttctcattcc ttcacttcct 3425281 tttcagacat acactgctca cgcagatata acagaatatg gaagggtaac gtgtttgctt 3425341 gtacaaattg ctgagggtaa acgcttcttt ttgaaaatat atctccaaac atgcggtgta 3425401 acgaaagaaa aaattgcggt ttttttgcgc ttctcacaag aatgttgatg ataaaatatg 3425461 acatatatag aattatgaag ggagggattt gcaaacgtga caggtgtcat atcttcttct 3425521 tccatcggag aaaagattaa cgaatggtat atgtacatac gccgattcag catacccgat 3425581 gcagaatatt tgcgacgaga aatcaagcaa gagctggatc aaatggaaga agatcaagac 3425641 cttcatttgt actattcact gatggagttt cggcacaacc taatgcttga gtaccttgaa 3425701 ccgttagaaa aaatgaggat tgaggaacag ccgagactgt ctgatctgct gcttgagatt 3425761 gataaaaaac aggctcgttt aactggtctg cttgagtact attttaactt cttcagaggc 3425821 atgtacgagc tggaccagcg ggaatatctg tcggctatta aatttttcaa aaaggccgaa 3425881 agcaagctga tattcgttaa ggatcggata gagaaagctg agtttttctt taagatgtct 3425941 gaatcttatt actatatgaa acaaacgtat ttttcaatgg actatgcacg gcaagcatat 3426001 gaaatataca aagaacatga agcttataat ataagattgc tgcagtgtca ttctttattt 3426061 gccaccaatt ttttagattt aaaacagtat gaggatgcca tctcacattt tcaaaaagct 3426121 tattctatgg cagaagctga aaagcagccc caattaatgg ggagaacttt gtacaatatc 3426181 gggctttgta aaaacagcca aagccaatat gaggatgcca taccttattt caaaagagca 3426241 atagctgttt ttgaagaatc aaatattctt ccttccttac ctcaagcgta ttttttaatt 3426301 acacagatcc attataaatt aggaaaaata gataaagctc atgaatatca tagtaaggga 3426361 atggcttatt cacaaaaggc cggagatgta atatatttat cagagtttga atttttgaaa 3426421 tctttatact tatcaggccc ggatgaagaa gcaattcaag gattttttga ttttctcgaa 3426481 agtaaaatgt tgtatgctga tcttgaagat ttcgctattg atgtggcaaa atattatcat 3426541 gaacgtaaaa attttcaaaa agcttctgct tattttttga aggtggaaca agtaaggcaa 3426601 cttattcaag gaggagtgag tttgtatgaa attgaagtct aaactattac tctcttgtct 3426661 ggctctaagc actgtgttcg tggcaacaac tattgcaaat gcacctacac accaaattga 3426721 agttgcacaa cgaggaatga tttaaccgcc gtccatcggc ggttttttcg tcccctcttt 3426781 accaaagtct cccaatccat gctatgatct tttcaataat cttgaagaga gtggaaatgc 3426841 agcatgtctc taaaaagtgt gagaacccac tttactcaat ggaatcgaga aaatgatgtg 3426901 acggagttcg aaacgtcgag tgcgacagtt gaacaggcag ctgagacaat cggcgtaagc 3426961 ctgtctagaa tcgccaagtc cctgtccttc agaggggaag gagatcaggt gattctgatt 3427021 gtggcagccg gcgatgccaa gatcgacaac aaaaagtcca ggcaaacatt tggctttaaa 3427081 gcaagaatgc tctctcctaa tgaggtgctg gagcagacag gccatgaaat tggaggagtt 3427141 tgcccatttg gattggctca tgatcctgag gtttatcttg atgtatcgct gaaacggttt 3427201 cagactgttt tccccgcatg cggcagcaga aactccgcta ttgaattaac accgaaagaa 3427261 ttatccgaat tttctttctc aaaagtgtgg attgatgttt gtaaagactg ggaataaaaa 3427321 aacatccaga catcgtctgg atgtttactt atttcacaaa cccaagcagc atttcacgga 3427381 tgattttgct ggctgtgttt gccgtttgct ctgagtggtc gtataccggc gcgacttcca 3427441 ctaaatcagc gccctttacg tttacctctg aacgcgcaat ttcatggacc gatgcaagca 3427501 gttctttaga cgtgatgccg ccggcgtcaa ccgttcctgt acccggtgcg tgtgcagggt 3427561 ctaatacgtc aatgtcaatt gtgacataaa ccggacggcc cgccagcttc ggaagcacct 3427621 ctttcagcgg ttcaagcact tcaaattttg agatgtgcat gccgttttcc ttcgcccatt 3427681 caaactcttc tttcatgccg gaacggattc cgaatgaata cacattgtgc ggtccgatca 3427741 attctgccgc cttacggatc ggcgtggagt gagaaagcgg ttctccctca taatcaacac 3427801 gaagatctgt atgtgcgtca aaatggataa tcgcaaggtc tgggtatttc ttgtacatcg 3427861 ctttaatgac aggccatgac acgaggtgct ccccgcccat acccattggg aacttccctt 3427921 tttctaaaat gctgtccacg tactcttcaa tcatatccag gcttcgctgc ggatttccga 3427981 acggcagcgg aatgtcgcca gcgtcaaaga agttcaagtc agccagatcg cggtctaaat 3428041 atgggctgta ttcctcaagg ccgattgaca cctcacggat tctgcttgga ccaaagcgtg 3428101 agcccgggcg atagctgact gtccagtcca tcggcatgcc gtaaagaatg gcgtccgcct 3428161 cttcccactc gggacggctc gcgataaata cttttcctga ataagcttca tcaaatctca 3428221 tctataatac cctcgctttc ctgtaaaaaa gcgcaagatt cgctcctgcg ccataccttc 3428281 attatttaat caggtcactc acaaatttcg gcagaacaaa cgccgcttta tgaatatctt 3428341 ttgtgtaata tttcgtctca atatcgaaga aacggctgtc ttccactgca agcggatcat 3428401 attttttcga gccaattgta aatgtccaca aaccgcttgg atatgtcgga atgttcgccg 3428461 tatacagctt cgtaatcggg aagatttcct tcacgtcgcg ctgtacattt gtgattaatt 3428521 ccggtgtaaa ccatgggttg tccgtctgcg caacgaaaat accgtcttct ttcagcgctt 3428581 ttgcgattcc tgcgtagaat ccttttgtaa acaggtttac agccggtccg actggttcag 3428641 tcgaatctac catgatgacg tcatattgat tttcagattt tgcaatgtgc ataaatccgt 3428701 catctacctg cacgtcaacg cgcggatcat ccagtttgcc tgcgatagaa ggaaggaact 3428761 ttttagagta ttcgataacc ttgccgtcaa tatctacaag tgtcgctttt ttcacgcttg 3428821 ggtgcttcag gatttctctg ataacgccgc cgtcaccgcc gccgactacg agaacgtgct 3428881 ccggatttgg gtgcgtgaat aatgggacat gcgccaccat ttcgtgataa acgaattcgt 3428941 ctttttcaga tgtcatcacc atgccgtcca aaaaaagcat gttgccgaac tcttctgttt 3429001 ccaccatttc taaatgctga aactccgttt gttctgtatg taacgtcttg ttaaccttca 3429061 tcgtaatgcc aaagtttttc gtctgcttct ctgtgtacca aagttcgctc aattgtcatc 3429121 tccctttcga ggctgtattc atttattgta agcgtcttat cagcttttat tctcggttga 3429181 aatctcattt tcacctaagg aaaaagtata gaggatggcg gggaaaaagt aaagatgcgt 3429241 cctgttctgc gatgtttaaa aacgatcttt ttttctcata atagtagaaa cataaaaaaa 3429301 gggggaaccc gttgtggatg caatgacaaa taaacggctg agactgacgc tgaaaaccgt 3429361 tcgcgccttt atctttttag gggcttttgc ggccttggcg gcagctgctg tgtttatgac 3429421 tgtcattttg atagccaaat accagggcgc tccctcggtg caagtgccgc aatccacgat 3429481 tttgtacgcg agtgacggct caaagctcgg ggaaacgaac tacggcgaaa agcgctattg 3429541 ggtcccctta aaggacatga atccgacgat cgtaaaagcg acagtggcga ttgaagacca 3429601 gaatttctac gatcatcacg gctttgatta taaacgcatg gccggcgcgg cgcttgctga 3429661 cctgaaagca tttgccaagg ttcagggtgc aagcaccatc acccagcaat atgcgagaaa 3429721 cttatacctt gaacacgaca aaacgtggaa acggaaatgg aatgaggcgt tctacacgat 3429781 ccgtctggaa caaaactatt ctaaggacga gatattagaa ggctatttaa atacgattta 3429841 ctacggccac ggcgcctacg gcattgaagc agcttcccgc ctgtatttcg gcaagcatgc 3429901 caaaaacctg acggatgcgg aggcggcgct tttggcagga atcccgaaag gcccttccgg 3429961 ctattcaccg tatgtcaatg agacgaaggc caaggaacgc cagaaaacga ttgtgcggat 3430021 gatggaaaag cagcagatga tcagccaaaa gaaagcggat gaattgatca aggaacctct 3430081 ttcctatcag cctttgaata aacaagtttc caagagaaag gctccttatt tctacgacaa 3430141 tgcgatgaga gagctggaaa aaaagctcgg catgacacgg gagcaaattg aaacgagcgg 3430201 gttaaacgtc tatacaacgg tagataaacg gatgcagcgc atcgccgagg agaccattac 3430261 cgaaacggtt aacgcgggct ctgacattca agtcgggttt tcagccattg atccccgcac 3430321 cggaaacgtt ctcgcccttg tcggcggcag ggattatcaa aaaagcccgt ttgaccggac 3430381 gacacaggcg aagcgccagc ctgcttcgac gatcaagccg ttgctgtact ataaagcgat 3430441 tcagagcgga tttacgccag tcactttgat gaaaagcgaa gaaaccgagt ttcaaattga 3430501 tgcaaaggga gaaacctatt ctccaagcaa ctataacgga tactatgcca acaagccgat 3430561 tacgcttctg caggcgctgg cgctttccga caatatttac gctgtgaaaa cgcatctttt 3430621 tctcggcacg aacaaacttg taaagacggc aaaggaattc ggcattaccg cccatcttca 3430681 agcactgccg tccctggcac tcggcaccga acccgtacgt ccgattgaga tggtcaacgc 3430741 ctatgccatg ctcgcaaatg gcggaaagaa aatcgaaccg acttttattt caagagtaac 3430801 ggacgcagcc ggccacgtgc tgtacgaaaa cccgaatcag cataaacagg tgcttgatga 3430861 aaaagccgct tttgtcacag cgagtatgat gacaggcatg tttgatatcg atttaaatgg 3430921 atatacgtcg gttacggggc gaacgatagc caaccgcctg acaagaacgt atgccggaaa 3430981 atcaggaacc accagcgcag acagctggat gatcggcttc aatccgaagc tggccgccgg 3431041 tgtttggacc ggctatgaca aaaacagcac catcgactcg gtcgaagaaa aaagctatgc 3431101 taaaaccatt tgggcggact tcatggagga cgcgctcaaa ggcgaaccgg aaaccgcgtt 3431161 caagccgcca aaaggcgtaa ccggtgtgta cattgatccg gaaacaggct actcatcagg 3431221 tcccggctgc gccgctaagc attacacata ttttgtgaaa gggacagaac ccgcaaacgt 3431281 gtgctacggg gcagaacccg caaaacaaac aaaagaccgg cttccatcca aagaaaagcc 3431341 cgcttccgag aaaaagtggt gggacaaatg gctggggcga catcattgaa aataacccgg 3431401 ctcctcggag gccgggttat tcgtatggtt ccttcataat cgatggaaga atgttagaca 3431461 atcgagctga acaatcagtt ttgggataaa gtggtgaatt tctcatttct tcggcgctgg 3431521 ctttcatctc ccagtcgccg actcatatcc ccctaaaaat gaaaaacccc gagtcttgtt 3431581 tcggctcggg attttccatg tcctatttct gtatcaccag tttactcaat gtttacgaaa 3431641 aatatctcaa atactttaaa agttcacaaa aaattcataa attaattgtt ttctggaagc 3431701 aggctcgttt ttaactcatc tgaggaacgg tcccataggc cctgatcatg ctttttcaga 3431761 aattcgccta gtacacgctt cgagctgtcg tccattttat caacgatgat tttccgtttc 3431821 atggatttat ccatcagatt cacatgctca ggcagtgact tgtagcctct tctgatgctt 3431881 ctgtcgaccg tcatttcaca ggctgtcaca ccagcgtaat aaggcccctc ttcttttctg 3431941 tcaatcgtta cccacacaag ccagtatggt tttccgttcg gcacttcttc tttattcggg 3432001 agaaatttaa ttcctttttc aacggtgctg cgggcatgca tagcgccgat gtctacgaac 3432061 gcttcttttt cctctacatc aacgaatacg ggagaaatgt tatcaaggct gagtgcccct 3432121 acgccaaaac cgccgtgtcc gtctgtcgga tcacttttga taatattaaa cccgattgat 3432181 tttttctttt tttcttccat gaagttctac ctcctacaaa agcggttgaa atatcgctga 3432241 aaacagcttt aaaatcgaat ctcttcctgc attgagcatc ggccacagca cgtaagatcc 3432301 tagcggtgtc acaaacagca ccaaaaatac gataaagccg tagctctccg cctgcgtcat 3432361 tttggcacgc acgcccggcg gaacgagatc ttctataatt cgatagccat cgagcggagg 3432421 aagcggcagc agattaaata aaaacaagac aagattcagc tgtatccaaa tagaaaaaaa 3432481 ctgatccagc cccgtgctga acgccgcaag catttccatt ccgtacgcat gcatcaacac 3432541 taacaaaaag aaaccaataa acgcaagaat caggttactg acgggcccgg ctatagatac 3432601 gagcacacca gcaagccggg gtttcttaaa gaaacggcga ttcacgggaa tggggcgcgc 3432661 ccacccgaat ccggccacca gaatcaaaat ggttccgaac ggatcaaggt gtttaatggg 3432721 attcagcgtc agtcttcctt gttttttcgc cgtatcgtca ccgaatttgt atgcgacata 3432781 agcgtgggca agctcgtgca tcgtaaacga cacaattagc gtgatgacga ggtatggcat 3432841 taaagataac ggataatata aaaaacggtc caagtgagat atccctcttt ctcaaaatgc 3432901 aagaatttac tttattcagt atactataag aagcctcttt ttctaaagag aggaaacgag 3432961 ataaaggagg attcagcacc catgccatac gtaactgtca aaatgctcga aggccgtaca 3433021 gacgagcaaa aacgcaatct tgtcgagaaa gtaacagaag ccgtaaagga aacaaccggt 3433081 gcttctgaag aaaaaattgt tgtctttata gaagaaatga gaaaagacca ttatgccgtc 3433141 gcaggcaaac gcctgagcga tatggaataa tctctataaa gccggcgctt cgcgcaccgg 3433201 cttttattat ccctattgag ccagcttcgc aataatcgcc aagaacgtct ttttctcttc 3433261 ggctgttaaa cgttcaaaca tgccatcaat cagctgctgg cggttttcga tcatttgttc 3433321 agccgctccc cggcccgatt cagaaagagt aatccataca gtgcggcggt cattgttatt 3433381 tctggatctc tcaataaacc cttcctgctc taaatgattc agagctgtgg tcgtggcaga 3433441 gggagacagt gtgacctcct tcaaaatatc ctttatggtg cagctcccat gtctgtatat 3433501 gatccgcaga ataaaccctc ttacattatt cacgtgtttc ggaacggtgg cttcatctaa 3433561 ttgcttcgtg cttttcaaat actttgtaag tgcgtgatcc agcaaatttg cttccagttt 3433621 gtcatggtcc atgtcaattt ccccatttcg agatgcattc ataacatacg aacgatatga 3433681 tttacttatt attttactga ttccgaatag ggaaagtcaa aaaagcaaaa tgtgaattca 3433741 cagcttttat cctacatgcc tcgattttcc acctgtttca caagtttatc tttaaaagtt 3433801 tggaaaggaa cgtgttcatt ctgctgatgt ccgaatcggc ggacgtttac cgcattctcc 3433861 tgctcctcat gatctccaag caccagcacg tacggaattt tttgcacctg cgattctctg 3433921 attttatagc cgagcttctc attgcgctca tcaatgccgg ctcttatccc cgcctgcttc 3433981 agctccgcct gcacttttct gcaatagtct aagtgaacgt gcgaaaccgg tatgatttga 3434041 acctggatcg gtgcgagcca gactggaaaa gccccaccgt aatgctcgat caaaatgccg 3434101 aagaaacggt cgattgagcc gaaaaccgct ctgtggatga caacgggacg aaccttctca 3434161 ttgagttcgt tgatatatgt taaatcaaat ttttccggca tttgaaaatc aagctgaatt 3434221 gtcgcgcatt ggtggctccg tttcagggca tcttttatat ggaaatcaat tttcggcccg 3434281 taaaacgccc catcgccttc attgatctca taagagaggc caagctcctc aaggacgcgt 3434341 gctaaggcac gttccgacgc ttcccaaagg ctgtcatcgc ctaatgaatc ctccgggcga 3434401 gtcgaaagct caacagaata ctcgaaacca aatgtccgat atacctcatc aatcagccga 3434461 atcgcttctt tgatctcact ctcaatctga tcctcccgaa cgaaaatatg ggcgtcatcc 3434521 tgacagaacg tccgaacgcg aagcattccg tttaaagcgc cgctgtattc atggcggtgc 3434581 acctgtccga attccgccat gcgaatcggc agatcccgat aagaatacag gctgttttta 3434641 aagatgagca tgtggccggg gcaattcatc ggcttcattg cgaatcttgt atcatccact 3434701 tctgaaaagt acatattgtc gcgataatgg tcccaatggc ctgactgctc ccataaccgc 3434761 tgattcatca taaacggcgt acgcacctca tcgtagccgg catttgtttg cagctcacgc 3434821 gagaagcgct ccagctcatt gcggacaatc tgccctttcg gcaaataaaa cggcatcccc 3434881 ggcgcttctt cagaaaacat aaacagccct aactgtttgc cgagcttgcg atggtctcgt 3434941 tttgccgctt cttctagcat atgcaggtgc gcatccaaat cttttttctt ttgaaacgca 3435001 accccgtaca cccgctgcag gacttcattt ttgctgtctc cgcgccaata agcgcctgat 3435061 actcttgtca gtttgaacgc cttgatcatc cctgtagaag gaagatgcgg ccctcggcac 3435121 aggtcaacga attccccttg ctggtacagt gtgatatcct ccccgcgcgg aatatccttt 3435181 aaaatctcaa gcttgagccg ctcgtctttt tgtgcaaaca gctcttcagc ttcttcgtaa 3435241 gaaacctcta tacgtttgat ttcaaggttc tcatttatta tgtttttcat ttctttttcg 3435301 atggcctcta agtctcctga tgccaagctt ttccccagct tcatgtcata gtagaagccg 3435361 tctaaaatca caggccctac ccccaatgac acttcgccgt acagccgttt tactgcttgg 3435421 gccagcacgt gcgctgttgt gtggcgaagc acctgcaagc cttcttgtga atcgagtgtg 3435481 acaatcgaaa gctcagcatc ctcctccagc ttgaaactga gatcaacaag cttgccgttg 3435541 acctgacctg cggccgcctt cttttgcaga ctggaactga tcgaaccagc cgcttctttg 3435601 attgtgatgc ctttcggata ttcctggatc tgtccgtccg gaagctgaat gtgtacatgt 3435661 ttgctcattt tagaacactc cttattcatt gttgtatata aaaaaacaca cccgtcccgc 3435721 agatagggac gagtgtgtga ttaacccgtg gttccaccca agttcccgac aaatactatg 3435781 ttgtcggctc ggtgctgtaa cgcagcatag acggcattgg ttacttcagt tccccaatgc 3435841 tgctccaagg cggtaaatga tattcctaag ctgggaagct ctcacctttc cttccctctc 3435901 tgaaaaccgt aactatcatt catgtccttt tcatcgcatg tattcaattc ataaaaaaac 3435961 acacccgtcc cacagatagg gacgagtgtg tgattaaccc gtggttccac ccaagttccc 3436021 gacaaatact atgttgtcgg ctcggtgctg taacgcagca tagacggcat tggttacttc 3436081 agttccccaa tgctgctcca aggcggtaaa tgatattcct aagctgggaa gctctcacct 3436141 ttccttccct ctctgaaaac cgtaactatc attcatgtcc ttttcttcgc atgtattcaa 3436201 ttcaaataaa aaaacacacc catccctcta aaagggacga atgtgttgat catccgtggt 3436261 tccacccaaa ttcccgatca attacacatg atgatcggct taaagatgct gtaacgcagc 3436321 atgacggtat cagatacttg ttttccctga tacggctcaa aggcggtaag ctgctttccc 3436381 tgcgttagga agatctcagc tgtccttccc tctctggaaa ccgtaaaaag catctcgtgt 3436441 ccttatcagt gcctgttgtt tcaataattt tttatatctt actatatatt cccacaaagc 3436501 gcaatcagtg atttacattt tttctgacgc ggcagtcccg ttatgggcag ccagaaacag 3436561 ccatacaagc aatgcagcga ggctgtatgc cgctcccatc atcaaaaacg caaacccggc 3436621 accagcatac caagtggcgg acagatgaat gatcaccccg gttatcgcta cgccgaccaa 3436681 ggctccgatt tgccggtttg catttaacgc cgcaccggcg atattcgtat gtctttgccc 3436741 ggcagcctgc atgatcacag ttgtcatggc aggaactgta ataccggtac agaggttcat 3436801 aacagacatc aacaccgcca gctgccaata aggaaaatcc ggagaaatca gcacaaacaa 3436861 cagcaatgca atgatacagc tgaccgccat tgatacaaac ataagctgac cggcttcaaa 3436921 ccgattcgcc agacgggcaa acagcagatt gccgatcacg aagaccgcca tcatcggcag 3436981 cagctccact ccagccataa aggaacttgc ccctcctgct tcctgcaaaa aaaggctgag 3437041 cataaacatg ccgccaaaaa gggcgaaatt cagcaaaaac ccgataaatt gggcagctga 3437101 gaagcggccg tttttgtata aggacgccgg caggatgggt gtttttgcag aaatttcccg 3437161 cagcaaaaac agcacaaatg ccaaaaccgc tgcagtaaat gctacaagaa tcactggcga 3437221 gcgccagccc gctgaaggcc cctgtatcaa agcataggaa agaaacccga gagccatcat 3437281 gccaagcaga tgcccgatga tgttcacgcg gctgcttttc ccaggaacgc ggctgaggat 3437341 tcggtaagct gaaatgagcg cagcagcccc tattggcaca ttgatcagaa aaatactctg 3437401 ccagcccgcc aactgtacca gcacgccccc gataaaaggc ccaagggctg aagcggcgga 3437461 aacaagcgcg gcccacagtc caaacattct cgcccgcgcc cgctcatcaa ggtaagaggc 3437521 agccaaaagg ctgagtgagc ttggcataaa caaagctgcc ccaattccct gtatgagacg 3437581 tccggcaatc agcatctgcc catttataga tgcagcgcat agacaggagg ccataacaaa 3437641 aacggctaga cccaagatat agatcgtctt cgagccgaaa cggtcagcca aggctccgcc 3437701 cgccagcaga agcgacgcaa aagtaagaat gtacccgtcc acaacccacg ttacacctga 3437761 aagtgacatt gaaagagtgt ttttcatatc agccatcgcc acattcacaa cggtcacatc 3437821 aagagttgcc atgaggaaac caagtgcgag cacgatcagc acggatatgc ctgttgatga 3437881 tgttgattct tgtatagacc cgctattttt cattacaatt gccctttcac ttgcttgatt 3437941 acccaatcat ctattttttc aagatcatac aattccccga ctctgtccat aacatgctgc 3438001 aaggattctt ctctcataag attggaccat ttatcctcga tttccgccat gactgtctcc 3438061 agcacacagt gactttcacc ctcaaataca gattgcagca agcctttccc ctgatacatc 3438121 gaacctctgc cttcgaccgc ttgataaaca tcataaagcg taatgtcagc caaaggcttc 3438181 gtcagggtaa aaccgccctt cgtccctggt aaggattctg ccaaaccggc ttgaaccaat 3438241 gttctcatca gcttcttcaa gtaagacgga gacacgcgca atcgctggct tatagcctct 3438301 gacgtcaaag aagcctgtac cggcagccgt gacagtaaca gcagcacaga aaccgcctgc 3438361 tccattcctg atttcatttt catcctattc actcctgatt cattatggat aactattatc 3438421 cataatgaat ctcttagcag cttttgtcaa taaaaaaagc aaaagaaacg gatcatttct 3438481 tttgcttggt atggttaaca aatctgcttc agttcctcta tgtattgaag cgcttcgtca 3438541 tattcttcat ttgtatattt ttgcttgctt ttgatggtaa agactttttc tttcttttcc 3438601 tcatcctcaa gcccgtcaaa gtaaaggatc gtggaaacca gctctaaaaa ccgtgatgaa 3438661 cggctgttta cactgtcgat atagcctttc atatccggca tgtccagatc agcatggtct 3438721 aaaaatgcgg agcctgtctc agtcagcgaa taccggtatt gaaagtagcc gccctttttt 3438781 tccttcacct catgcagaaa tccaaggttg cacagctctt caatctggag cgtcagttcc 3438841 tctgaatatg gtccgtaaaa gtgaaaatca tatttctcat agaaaggaaa ctgcattttc 3438901 ttggcgatat aaatcatttt ctgcagcttc tttcgcccga tgatttctcc agaatccgag 3438961 aacaccttca tcagttttgc atgttctttc aacaaattcc cgacatctcc tttttccttc 3439021 tttccaattt ctatgtcagt cccagcagct gccggatttt cattttcgct tccggatgtt 3439081 tagtgccgtc acaaatcaag tcctttggat agtacagctt gtggtccgtc cgccgtttac 3439141 ctgagatgga ttccacaata gccgactgtc tggacagctc tttaatttgg ccgttttgcg 3439201 tcaagagatg gatcggcaga cgctcctctt cctctcctgg tcggtaaaaa tcgtatggca 3439261 gatctgatga agaatcaacg accaaataat agctcggatc gatccccgcc tctttgaaca 3439321 atgaagtcag ctcaaaataa gccgacattt cttcattcgg attgaattca acgtattgga 3439381 aaagctggcg gttaatgaat ctgcggcaca agtcggataa aatcgcgtct tcttcatcct 3439441 cccaggcctg gaagtaatac aaaataatag attcatccag ctttacataa tcctccagtg 3439501 tcaattttcc ttcaaaaata gaatagaaat gaaccggagc gtgagtgaag acatagcctt 3439561 catcgtgcag ctgcttcgcc ctgtgaagaa tcttcgttaa aatgacctct gcacttctag 3439621 tcacaggatg gaagtagacc tgccagtaca tttggtaacg gctcatgata tagtcttcga 3439681 cagcgtgcat tccgctttct ttaatgacga tctgatcctc gcgcggccgc atcacccgaa 3439741 gaatccgctc catatcaaaa tggccgtagc tgacgcccgt ataatatgcg tcgcgctgga 3439801 ggtaatccat gcggtctgcg tcaatctgac tcgaaatcag gctgaccact tgcttgtttt 3439861 tatatgtttt ggcaatgact tcagcaacat cctgagggaa acccgggctc acctttctga 3439921 gcacctgatt aacctccgtg tctcccaaaa tgatacctct tgtaaaatcc tcgtggtcaa 3439981 ggtgaaagac cttttcaaat gaatgcgaga acggcccgtg cccgaggtca tgaagcagcg 3440041 ccgcggccaa acagagttcg cgctcactgt catcccattc agggcggcct ttaaagacgt 3440101 catcaaccat tcttctgaca atttcataga caccgagaga atggttgaac cggctgtgct 3440161 cagccccatg gaacgtcaaa taggtcgttc cgagctgctt aattctgcgg agacgctgaa 3440221 attcacgggt tccgatcaaa tcccatatca gcttgtcccg aacatgaaca tagcggtgca 3440281 ccggatcttt aaacactttt tcttctgata attttccatt tggatacgcc atcgtcattc 3440341 cctctttttt ttagccgtgt ttctattata tcgactctat tctttgaaaa catccttgaa 3440401 tttgcccggc gatttgttcc atcttcatga aaaacacatc ttgtgaagca aaaaagcctg 3440461 acctgagggc cgaggctaag aaaaaatatg tttttacttt tttattttct tttttacttt 3440521 gtcaatcagc tcatcctctg tcggagctga cagcgggcga ttgttcacaa aagcaaatga 3440581 ttttttccgt ccgggcccgc aataagattg gcatcctacc tcaacctttg cgtccgggtc 3440641 cacttctttc aaacgcggca gcaatgtttt gatattagtg gcttggcaat catcacacac 3440701 tcgaaattca ttagccatga cgtacgcttc ccttcatttc tatgttcatc tatgtgaata 3440761 acctaaaatc acgtttcaaa aaaaatcaca tcacacttca ttttacaagg attcgactgt 3440821 tcctgcaagc cgctccatcc ttcgtatctc ctattctttc agccaatttg tataaatatt 3440881 ttccaacctg gacattctaa taccatgaaa agaaaaatgg gagttgagat aaatgacaaa 3440941 acagcgacaa gacgcttggt cagaggaaaa cgatctgctt ttagccgaaa cagtgcttcg 3441001 gcatgtgagg gagggcagca ctcagctgaa cgcctttgaa gaagtcggcg ataaattaaa 3441061 ccggacatcc gcagcctgcg gattcagatg gaacgcagtg gtccgccatc aatatgaaaa 3441121 agcgcttcag cttgcgaaga aacaacgaaa acagcggatg agagcgctcg gaaacgggca 3441181 gcccgcgaaa aaaagattat tatatcagcc tcctgccgtt gatcctgaaa tcattcaaga 3441241 aaccgctgca gaagagccgg ttaaaacgga aacaccatct gtcgaaaatg agcaaccttt 3441301 aatgtctggc gaacacatgc cttttgttga tgaaagcttt aaggaagagt tagctagtct 3441361 atcacactta ttgtctcctc aaacgcctgc agctgcgcct gagatgacga tgaatgatgt 3441421 gatccgcttc ctgcagaatt acgaaggcaa tcacgagcaa tcatcagcat taaaaatgga 3441481 aaacgagcgt ttaaagaaag aaaatcagga attgcaaaac aaaacagagc agctagaggc 3441541 agaagttcaa aagcttgaaa aagaccaaaa aacgatccaa gaagattatg aaaccttggt 3441601 gaaaattatg aacagagcca gaaagctagt tttatttgaa gaagatgaac atgcctctcc 3441661 gtccttcaaa atggaccgga acggcaattt agaaaaatta gcggaatgac atagaaaaat 3441721 cccaaaacgg gcagctgttt tgggattttc gccatgtgca aaatcccctt ttctattgag 3441781 aaaagagaat ttcctcattt tgcagccgga tcagctattc ttgtaaaatg aggccaagct 3441841 tatgtgaatc tattaagaca tgtgagctgc ctcggccgtt ttttgtttcc gaggcgcagc 3441901 agaaatgacc aaaagcccca gcatcataag cgcaatgccc agccacgagg aaggcgaaag 3441961 catttcccct atgaaaaaca cgccaagcaa tgaagccgtc agcggttcag ctaaagacag 3442021 cgtgaccgcc gccgaggccg gaaccccggt aagccctttc gcaaacaaaa agtatgcggc 3442081 acatgttgca attaacccga tgtaaaggct tgttcccagt cctctagggg tcaatatcca 3442141 cgagatatct aactgccata atagcggcgt cagcaagatg gcgctgatca tgaatacaac 3442201 ggcggaggtc gctcgcggag gctgggtttt catcatcgct ttactgatga gcgtatagcc 3442261 tgcaaaagaa gcacccgctc caagcgccat aagaacacca gccacatcaa tccgaacatt 3442321 ggaactgtcg gaaaacagaa gccagcaacc cgctaaagcc agcacagtcg caatccacca 3442381 ggagtttcgc gggcgtttct tcaatacagc ccattcgagg gtcccggcaa tgataggcgc 3442441 actgccgatg gcaatcacag ttcccactgc aattcccgtt tctttaaccg ctgtgaaaaa 3442501 cagcggctgg taacacgcca tacaaacagc ggctaaaaat acgagcggcc atgcccaatt 3442561 tttcacgtga agctcccggc tgatccaaac cgcaagcagc atggcgcttc ctcctattaa 3442621 taacctgaac gctccaaatg ccagcggtgt ggcgctttct ggagccaatg cctgaacggt 3442681 tcccgtggtc ccccagaaaa aagccgcaat caatacaaaa aggctgtaaa tattcccctt 3442741 catctgcctc tcccctttaa tatggatgct gatgtcattt tatcgttttt ctttttgtcg 3442801 tggttatctg tatgtaagaa ggacttatct gaaaataaga ttattgaggt aaaatgccgc 3442861 ttgagataaa aaatgcatgc cggcatatac agccggcatg cgaagaacgt tcacccaaat 3442921 acctttgcat tccgctcagc catccggacg aggtttttct caaattccat ttcctcatca 3442981 atggacagtc cagctgaata aagatgggtg cttaacgctt ttaattccgt caataaagcg 3443041 aacattaagt cttgtacgga gatgtctttt tgaagaagct cacttaagga cgccatcgtt 3443101 tccggacgta tttccggata gacgcctttt ttatcgtttt gtttgtcttt cagcgccgct 3443161 tgatagaatc gtctgatcaa gtcggccctt tcactgccgc ttttatctgc acagagataa 3443221 atttgaacag cgactccgcc gcgaacgcgt ctctgagaga tgccggcgaa ctttttgcca 3443281 tttatactga ggtcatagct gccgggacaa taagaccctt caatttcata ggcttcgatc 3443341 tttgcgttgt acggtctcag cattcgtctc atcagctcga ccatcgcttc atatcctttg 3443401 tctatatcga tgcctttctt ttcgtcctcg aatatgagag agatatttaa aacaccgtca 3443461 tccaatacga cggcaagacc gccggaattg cgtacgatca cacggtatcc ttcgctctcc 3443521 agcaaggaga taccatcctg caaaaacggg aggcgtgtat cctgtattcc aaggacaatt 3443581 gtatcgtggt gcacccatga gcgcgctgtc gccggcgaca cgccttttcc gacggacatg 3443641 catagcgtat catccattgc gaaggattgc ttcgcatcaa ataaagggcc gagactggat 3443701 tggtcaatga ctctccattt cggctgcatc agtaaatcaa tcggttggtt tgccatctat 3443761 gtaaaaccct ttcatgttag gcttattgaa cgaaaactat tatatcattt cagcagctgt 3443821 gattgataat tgcttttcag catcgtaata aaaatttctt tattttttgt attctccatg 3443881 agaggagaat gaatgtaaga cagcttgcgc tttaacgaga aattattaat atgcagaatt 3443941 gaaatttcgc ggtggatcaa atccttacgc agcacgcttc tggatagaac cgaaagtccc 3444001 atgccgttaa tcaccgcttc ctttacacct tgattgctgc tgatggtaaa cattgatttc 3444061 ggccgaagtc catttgaact gagtacatga tcgagatatt ctctcgtccc ggagcctttc 3444121 tctcttgtca cccacgcttc gttctgcaaa tcgctgatcg aaatctcttt ccgcccggcg 3444181 agcggatgct gatttggagc ggcaatgcac atttcatcct ccatgaacgg ttcaatttcc 3444241 agctcattct cgtttgtatg tccttcaatc agcccgatat cagcctgaag catccgcaca 3444301 cgctcgctga cctcctctgt attgccaatc atgacatcta gattcagctc tggatacagc 3444361 ttttgcagct gggccaatag cggcggaaga atatactcac cgattgtaaa gcttgcagct 3444421 attttcaatt cacccttcac atagtgatga tgcgcataga tttcagcctt ggcttgttcg 3444481 tagagaaaca ccatttgctt tgctctttga tataaaatgt ctcctgtcgg cgttgtcgta 3444541 aagtgttttg gcgacctgtt cagaagagcc gtttgaaatt ctttctcaag atttttgata 3444601 tgcagactga cgctgggctg ggagatcatc agcttttccg ccgcttttgt gaagtttttt 3444661 tcttctacca ccgctataaa cgttttcagc acgtcgtaat acaaaaaccc cacccctgtc 3444721 attaatgaaa tatatggtta tgattagttt tctttattgt actcatatca tccgtcttgg 3444781 taaagaaggg ctatacagaa gcgcaaaaaa ggcagccctc ggtcgagagc tgccattgtc 3444841 ttcaatttta ttacagtgct tgcgccgctg taattaatgc gagattgtaa acatcttcag 3444901 cgttacatcc tcttgaaagg tcgtttacag gcatatttaa accttgcagg attggtccta 3444961 ccgcttcaaa gttgcccaaa cgctgagcga ttttatagcc gatgtttcct gcttcaagac 3445021 ttgggaatac gaatacgtta gcgtcccctt tgatctcgga atccggcgct tttttctcag 3445081 ctacagatgg aacaaatgca gcatcaaatt ggaattcgcc gtcaagtgtc agttcaggcg 3445141 ctttttcttt cgcgattttc actgcatccg ctactttttc tgtttcatca gattttgctg 3445201 agccttttgt agagaagctg agcattgcca cgcgaggctc aatgtcgaac atttttgccg 3445261 tattggcact ttcgatcgca atctcggcaa gatcttggct gtcaggtgca atgttgatcg 3445321 cgcaatctgc gaatacgtat tgctcttctc cgcgagccat gatgaacacg cctgaagtct 3445381 ttttcacgcc ttcttttgtt ttgatgattt gaagagccgg gcggacagtg tcagcagttg 3445441 agtgagcagc tccgcttaca agtccgtctg caagtccttt atacaccagc attgtaccga 3445501 agtagttctc gtctaataat gctttacgag cctgttcttc agtcgctttg cctttgcggc 3445561 gttctacgaa tgcttgtaca aggtcttcca tgccttcata tgtatgagga tcataaatct 3445621 taacgccgcc cagcgtaagg ttcaattctt ttgcttttgc ttggatctca ttttcattgc 3445681 cgatcacaat cggattcagc actttgtttc ctgcaagctt gctgaccgct tctaaaatac 3445741 gctcgtctaa gccttcagga aatacaattt taacgtcttt tccagctact ttttcttgca 3445801 ctgttgaaaa taaatctgcc acaataaaac ctcctcaaaa agttacaaaa acgctttctt 3445861 ttactagcat actcttcttc caatcaaatt caaacagcca actttcatta tagcgctttc 3445921 ataaaaaaat cttatttttc taactaattt aagtgactca atcttccctt ataggttctt 3445981 ctattttgat ggagttatac ggaagggatg ttcaaggttt ctccacagta gaatcggata 3446041 aactatggta tagtgaaggc aatcatgaaa agataatggg agtgaagata aatgagtgaa 3446101 cagcaaatga cgaatgaagc ggcaaaaacg cttgacggct ggtatgcgct tcatgatttc 3446161 cgcacaatgg attgggcttc ctggaagctt ctgtccagtg atgagcgcca atctatcata 3446221 catgaattca ccgggttgct tgaaaaatgg ggcgtagccc aaaaagaagg aaaaggatcg 3446281 caaactcttt acagcatcgt cggccaaaaa gctgatttta tgctgatgat ccttcgtcct 3446341 acaatggaag aattaaatca aattgagctt gaattcaaca aatcaagact tgctgagttc 3446401 accattccgg catactccta cgtatcagtg gtagagctga gcaactactt ggcaagcggt 3446461 gacggcgatc cttatgaaaa tccgcatgtg cgcgctcgcc tttaccctga actgccggaa 3446521 tctaaatatg tatgcttcta tccaatggat aaaagaagat ctggcaacga caactggtat 3446581 atgctttcaa tggaagaacg cagaaacttg atgagaagcc acggtttaat cggccgcagc 3446641 tatgcgggca aagtcaaaca gatcatcacc ggctctgtcg gctttgacga ttacgagtgg 3446701 ggcgttacat tatttagcga tgatgtcctt caattcaaga agctagtgta cgaaatgcgt 3446761 tttgacgaag tcagcgctcg ctatggcgaa tttggttcat tctttgtcgg caatcacctt 3446821 tcgcttgata cacttcctca attcttatat gtataatatc ccctcccgcc ctatccggcg 3446881 ggagtttttc aattctcctt tatcagaatt taaataaaat ttgctatttt cttcgttttt 3446941 tcttacgatg tagataataa tccatttttt tcaaaggggt gcagttattt gtcaaaacga 3447001 accgcatttg ttatgggagc cagtcaaggg atcgggaaag caatcgctct gaaattagca 3447061 gaccagcact tttccctcgt cattaattcg cgaaatttgg ataatattga atctgtcaaa 3447121 gaagacattt tggccaagca tcctgaggcg agcgtcattg tccttgcggg cgatatgtct 3447181 gaccagcata cgagagcggg catttttcag aaaatcgaat ctcaatgcgg acggcttgat 3447241 gttctgatta ataatatccc gggcggcgcg cctgacacat ttgataactg caatatagag 3447301 gatatgacgg ccacgttcac tcaaaagacc gttgcctata ttgacgcaat caagcgtgct 3447361 tcctcactga tgaaacaaaa cgagtttggc agaatcatca acattgtcgg aaatctgtgg 3447421 aaagaacccg gcgccaacat gttcacaaac agtatgatga atgccgcttt aattaacgcc 3447481 agtaaaaata tttccatcca gcttgctcct cacaacatta ctgtcaactg tctgaatcct 3447541 ggttttatcg ctacagaccg ttatcatcaa tttgtggaaa atgtgatgaa aaagaacagc 3447601 atatccaaac agaaagcaga agaacagatt gcttccggga ttccgatgaa acgggtcgga 3447661 tcagccgaag aaaccgcagc gctcgccgca tttcttgcct ctgaggaagc ctcctacatc 3447721 acgggacagc aaatttccgc tgacggcggc agcatgaaaa gcatataaaa acatcccgct 3447781 ttttagcggg atgtttcttg taatgacccg aacggcaggt tcagcttttg aatccgcgtg 3447841 acaaattccc gcagatcctc ctgcttcgac accattgaga ttctgacatg cctttttccg 3447901 ttgcttccaa aaatttcgcc cggtgtgact acgacatggg catgctccag caagtaatcg 3447961 gaaaattggt gagatgtctc aaacgtattc ggaatttcag cccatacgta aaaggttcct 3448021 tttggctttt ccatcttcca gcccagttcc ttttcacaaa gcgccgtaaa aaagtcaatt 3448081 cgttccttat aaattcgttt caacgattcc gtatgctccg gatctccaga aagcgccgca 3448141 ctcgctgcct gctgcagccc gccgaacatg ccgacaaata catgatcctg aaattcattg 3448201 acggcctgaa tgattttttc gttcccaacc gcaaacgcca ttctccagcc ggccatgtta 3448261 aatgtttttg aaaatgaata aagctctgct ccgacagttt tggcatcctc tgcctcaaga 3448321 aagctggccg gtttttgatc gaattcaaac gccccgtatg caaaatcatg aatcaaatgg 3448381 atgttatgct ctttcgcaaa agcagcagct tttgcataaa aagccgcatc agccacagct 3448441 ccagtggggt tgttcggata gtttaaaaac ataagcttcg ctttttccag cacggctgga 3448501 tcaatctttt caaaatccgg cagatagcca ttttcttcat acagcggcat ttcgtaaagc 3448561 tcagctcgcg ccatcgtaat ccctgataaa tattcaggat agcctggatt cgggactaaa 3448621 gcgatgtctc ccggattgag caggcattgt gtcagcacat acaatccggc tttcccgcct 3448681 ccgaaaagcg cgacttccgt ttcaggattg attgtcactc cgtattccct tttatagaaa 3448741 gcggcgatcg cttcctttaa aaaaggatag cccctgaaag ggccgtatcc atgaaacgaa 3448801 ggattcagag aagcctcccg caaagcctcg acaatatgcg gcggagtggg aaggtcaggg 3448861 ttcccctgtc cgagattaat gatatgggct cccgtttttt ccatttcctt taccttttga 3448921 aaaacgagag aaaactcctg ccttggaagt gtcttgatga catcggacgg tgttatttcc 3448981 atctaaaaga ctcctttttg ctccgttttg ttatcccgtt ccaaaaacga tttgttgacg 3449041 agcttcgtat gcaaaaacaa accgcatacg atcacgacaa tcagccccat aatgaccgga 3449101 gcgcttagga tgttaatgaa cattgaacca atagaaatgc ataatccgat agacgcttcg 3449161 gccactgaaa aaatgcgccc ttgaatctgg tttgccgcat tttcctgaac cttcactttt 3449221 gcaagcactt ccccgtattc catcgcgatg aaaaagagga tcgccgcgat gacagaaaca 3449281 gcgaatatcg gtgtgaataa aaacagcgcc agcgagacaa tggataaaac ggtaaagtac 3449341 gtcaggcctc tattgttgtt aaagccccat ttgctgacaa gcgccgctcc gataaagccg 3449401 ccgaagccga tgcagaacgt gagaataaag ttgccgattt ccccgtcacc cagaaagcgg 3449461 ctgacaatcg gaaaatagct gtacacaact ccccacagca aagccattgt aatcatcgta 3449521 aacatggcgt ttaatacgaa tgaattggtt ttgatttcct tgagtccttc cttaaaagac 3449581 tgaaaggcct ctttaatgtt ttcagattga atcggcacaa attgcagctt gatgcggctg 3449641 ataaaaaatg ccgaaaccaa gtatgtcaca ccgttaaagg caacagccag ctctacagat 3449701 ccgcctaaca gaaagagccc tccggcagcc gccccgacga taatggagat ggttgtcgct 3449761 tttgcaaata acgtgttgat gcttttaata tctgattcca aggacgacat gacagcgaga 3449821 cgggcgggat taaaaaacac gccgcttcca taagtaataa acagcagggc cagaaaaatc 3449881 agcggatact cgccttttgg aagaaatgtg agccccaaaa agatgatgcc tctgatgata 3449941 tccgtccaca gcatgatctt aattctgtct aaccggtcga ccagaacacc caaaaacggc 3450001 tgaaacacca tcggaatgct tctgaccacg atgaccccgg acgtcaccca ataatcgtga 3450061 taatatgtag acaaaatgag cagggcaggg agaacacaat agtctcccat gaacgatagc 3450121 gcctgcccgt aaagcaagta tttagagttg ggtttcagct gtttcatact ggcagcacat 3450181 actttgccgt cagcttcgca tgctgctgaa tttgtctgat tgattcagcc acatcctgtg 3450241 aattactgcc tttcagttca aatgcagcaa tggaattgaa agcttcaaac aatgtcaaat 3450301 caactgaagt gcctggtgct gcggccgaaa aagaaacgat ttcagtatcc ccttttaaaa 3450361 gcccgtccgg aatatcgatc gcttcaatga ccaaatcctc agcagtttca ggaatttggc 3450421 cattttgttt gaaatgctgc gggtacaaat ggcagtcggc aacataataa ggctcttgat 3450481 ccaataatcc gtccggcaga tcggcgtctt ttccgaaaca gaggacatct aataataatt 3450541 gcgccatatc aaggccaaag acctttttaa tattggggat catattccag ccggcaaatc 3450601 tggctgccga ctctattaaa cccggttctc tgtttttcat tagcttgatc tctgtatgtg 3450661 ttgcgcaatt ttgcagtcca agcccttcat ttgccttttt ggcagcttcg acaattttct 3450721 tttttgcctc ttcatccaga atggacggcg taatgtggga tgtctctgta aacccgattt 3450781 gcggcgtttt atcatgaatg gcgatcggga aatactcacc gtcagccatg atgccttcta 3450841 tactgatata gtcggagtac ccttctgttt gataccagtc tccgtactca ccctgtaaaa 3450901 attcttcagc gataaacggc gcttcaaacg taaccgcctt tggcacgtta attgatttca 3450961 gatagtcatt gactctgtta aattcatctt ctgccgtctc agtgtccgta atcagcgtta 3451021 caccgataga actcgctaag tatgtaggct ttaagataag aggtgtgccg atctcttcaa 3451081 gagcagcacg gaaatcttca agagttgtga ctcgtttgtt tttgatcgat ttgactccgg 3451141 ccttattaaa agcgtccctc attttatttt tatctctggc attttcggct gcctgcacgc 3451201 cggcacctct caagcccaga cgttcacagg ctttcgccat cggagcaatg aataattcat 3451261 tgtttgttgt gatggcatcc gccccaaaca tttcggcaac cttgacgatt tgctcgacga 3451321 cctcttcctc aggcttgtta tgatcttcat gcgcccaata aatggaatca gggtgttcaa 3451381 aatcagctaa actcttaaaa tagtctttat cttttatgac cgcgaccgag tatttttcaa 3451441 tcaatgctgc atgggaggct gtaattgcaa aaggtcttgg aataaagctg accaggttat 3451501 atttttcagc agcgctttta taaaacatgt gcggcgggca gcctccaaga tcagcgatga 3451561 ccaatactgt ttttctctcc atatgtaaaa cactccttct ctattgtgcg gtgtatcctc 3451621 cgtctgcggt gatggcgctt ccggtcatat agcttgataa atccgaggct aaaaacagca 3451681 tcacatttgc gatttcttca ggtttcccaa gcctcagcag cggatttacc ttcgcttttt 3451741 cttttttaat ctcttcaagt gtgccttcat tattttcaag gaatgatttt tcattcagcg 3451801 gtgtgtcgat gatccccggg catacgcagt tcacccgaat ttgatgtttc gcataatcaa 3451861 cggccattga tttagtcagc tgcaaaaccc cgcctttgct ggcgttataa gcaggaatat 3451921 caggccatgc cacgagtccg ccgacagagc acgtattaat gatgttgccc ttgccggcgg 3451981 ccagcatatg cttgagtgca tgtttgctca ttaaaaacat gccggtcaaa ttgacttgca 3452041 gcaccttgtt ccaatcgctg agctccatct cgtgaatagg cgccacgatt tcgatgcctg 3452101 cattattaat caagacatcg agcccgccaa atgtatgaac cgccgattca actgcgtgct 3452161 ggcaggcagc ttcgtctgtg atgtccgttt gcacaaagtg cagcctgtca ttattttctt 3452221 ttcgtaccat tgcttctcct tgcgcttcat caatatccgc cacaaccaca ttggcctgct 3452281 ggcccaaaaa agcctgaacc gcagcataac caatgcctga tgcgcctcct gtgatgagga 3452341 cggttttatc ggtgaggttc atgatcattc atccgccttc attttttttg cttttgccct 3452401 gttatagcgc ggcgggaaga agatattaat cgattttgat tctttttctg aacggttgat 3452461 ggcaccatga tcttcgcgag gctcacagaa ataggctgtg ccgaatttca tctcgactgt 3452521 gcagccttcg accgtcatgt catagccgcc gccgatgcag atgcctattt gttcattccg 3452581 atgtttatgg aaaggcattt ctccgccatt tccagggatt ttggcaagca taatttctac 3452641 ccaatcctca acaaagaacg tgacttccat gcccggcagc aggtctcttg ttttgaaaat 3452701 atccaaaaag tagtcctcag gacttgtata tgtttcatca gctttcagcc gcttgatatc 3452761 aatagcaatc acttcttggt ctgtgtcgtt tcttgccccg tgaggcacat gcggcggcgc 3452821 gatataggca gattccaagg ctgtcatttt tcttgtcaca tctccgacag tcatcatcag 3452881 ctcgccagaa acgaccatgc cgatttggac ctccttatgc tgatggggtt caacattggt 3452941 atgcggcggg acgtaagaca ttaatacttc agtatcccct cgtacggttg aatactgcct 3453001 cactccgttt tcccattcaa ttaatttcgg tgtcgggaaa taaagctcct gcatatcttc 3453061 tttagttttc atcatcaacg tctccttttc caaataatga ccagctcatt ggaatgcttt 3453121 tgaatgtttt tacaaaggtt agcccgtact tttgccgtgc aagctcattg gttaaggcaa 3453181 tgtcatacaa accttctttt acttttcttg cggcttgact ggttgaattg actagtttga 3453241 aacgaacatc tttgcgggta aaatatttta ttaaattaat aggtgaagga tgtgaaacaa 3453301 taacagatgt atcaagcata tcgtctctga attcaaaatc aggacgaaca gccaggccgt 3453361 acatcggtgt atcgcacctg aagatctgca atagctgcaa atccggcctc atgtagaaat 3453421 gcttaatgcc atcgtaagca tgtgggacga tggtatattc cagcgggctt tggagcgtcc 3453481 tttcgatgca cgattcaaaa gtatcatgca aggacaattt actgttcagc ccttgtagaa 3453541 gagtaaaatt ggaaatgaaa tgctttgctg cgtactcact gcttgtcccc tcagggccga 3453601 gcgtgttgac tgtaatgagt ttggatagtg aatcagttct tttttttgtc tgaatgctat 3453661 tatccaatat aatcatgagc accaaccaat cttttaaaat tttaagtaaa ttttatccag 3453721 tggaaattga actgtcaatg ttttttgaaa atattgataa ttattcccat acaaacaaaa 3453781 aaacccttta aaaagggttt ttaattatag gaatttagaa actttgttta ttgagataag 3453841 gactgatcgg ccttctgctc aagtttgccg tactttttat atgcgaatac actgagcaca 3453901 aatccgagga ctgtgatggc ggcgcaaatc aatccgacag ctgcatagcc gtatgccaca 3453961 tatacgggtc ccattaaagc agaacctaat gtcacggcca gattcgaggc gagactgtaa 3454021 aacaccatga cttttcctcg atgacgctct gagcagtcac tcaaaatggt gctgagcagc 3454081 gtcaccgtca aactttgcat taatccccaa ataaataggc tggcgattaa cagaaacata 3454141 gacgccggcg catatggtaa acacgccagc agaacgctga tgacccccag cgcaatcaaa 3454201 agggagcgca tttttccgat gcggtcggct atctttcctg taatcacact catggaaaac 3454261 ccgattccat aaatcatgat aaataagccc gcagccgtgt ttcctccggt aaaaacgtcc 3454321 tgaagatagg tgcctaaaaa ggaatacata ccgtaaaaac caatcatatt acaaaaggtt 3454381 attgtgatat aaacaggtac acgagggact ttcagcgcat cccggaatgt tcctgcgggc 3454441 tcttctattt cttccttgcc gctgttttta tgttgggcat ggcggcgcat ttcaaggaga 3454501 atcagcagaa caactaaaac acccatcagg gcgaaaatcc aaaacgtcca tctccaatgc 3454561 aggacgccgc cgataaatga tccgagcggc actccgaaaa tcagcgccag cgaccagctt 3454621 gaaacgatca gtcccatcac cttgccccgg tatgtataag gaacacgatc accgacaact 3454681 gcgtaagcgg tcggaacaaa cgctcccgca gccaatcccg aaagcgcccg gcctaaaaag 3454741 aagaaaaaaa tattttgagc taaagcgcat atcaccgttc ctatgataaa aatcataagc 3454801 ccggccaata agctcagttc tctggagtat ttatcgccta atggaaccaa aagcggcgca 3454861 ccgataaaaa tcataacgcc gtaaatactg atagataacg caaggacgct gacatctgag 3454921 ctgaaggctt ttgctaaatc cggcagcagc ggtgagatca caagctcttc agatccggct 3454981 gcaaataccc ccatcgttaa agccagtgcc aacaataacg gaaaatgatg ttttgttttg 3455041 atgtcattgt tttgattgct gttcattctt tctcaaacac ctcttccata atcttcttat 3455101 cataaagttg tattatagtt tagcattgtt ttttctctat ttacaattcg aacgaaatat 3455161 ttataagttt tattattttc atttaaatcc cattatatat ttctatattt cattctaaaa 3455221 atacatgagg atgtaacacg taaaaaaagc tctccggcct cccggagagc tttttctatt 3455281 gcgcctctgt ctgctttttt tcaatcgttt catgatttat acgctttttg atgcttagat 3455341 gatagtatgc ataacagaaa ataatgatcg gcacaccgca gtataagcca attctttgat 3455401 ccggaatgaa aataaggctg atcaacacgc agccatataa acaaaatccg agaatcggga 3455461 ctagcggata aagcggcgtt ctgaactcca gatcattcac atttccgcct tctgccagga 3455521 aacgcctgcg aaagaaaaat tgcgacgcac aaatggacat ccacgcgaca actgtcacca 3455581 tgcccgagat tgagatacac cataaataca ctgtttctgc agccatgaca cttgtcagca 3455641 gcgaacagcc tgaaatgcct agcgtaatca gcagggcatt catcggcacg cctttttttg 3455701 tcagtctggt gagaaaggag ggacccattt gatttgatga aagtgaccac atcatacgcg 3455761 acgccgcata caatcccgaa ttagcaacag ataaaatggc cgttaagatg acaaagttca 3455821 tgatatctgc cgaaaatggg atgccgattt gatcgagtac tgctacaaac gggctttcaa 3455881 tcacccccgc cgttttgtac ggaaggatgg caaccaagac gaacatagcg agcacaaaga 3455941 aaaacagcgt gcgccaaata acatttcgaa tggactttgg cagtgttttt tccgggcttt 3456001 cactttcccc tgccgcaatg ccgacaagct ccgttccctg gaacgagaag tttaccatga 3456061 ccagcgtaaa cataacggcc agcaccccat tagggaaaag ccctctatca gtcataaagt 3456121 tagacaaaaa gggtgtctcc tgtccgcctt taaagtcaat caagccaaac acagcggctc 3456181 cgccaatcac aataaataat atgatcgccg ccactttgat gcttgaaaac caaaattcca 3456241 tttccgcaaa gcttctgaca gagagcgcat taatcaaaaa gatgacgatg ccgaacacga 3456301 ggcaccatat ccagatcgga acggagggca gccacctttg catcaaaatg cctgctgacg 3456361 tcagctctaa ccctactgta ttggcccagc tgaaccaata cagccagcca atcataaagc 3456421 ctgtcgactg tcccagaaat ttagtggcgt aggcctgaaa cgatccggcc accggcatgg 3456481 caacagccaa ttctcctaaa caaagcatga cgagatacat taaaaatccg ccgatgatat 3456541 acgcggcaat ggcgccgagc ggtcccgcct ggctaatggt aaagccagag cctagaaaca 3456601 gcccagtgcc aatcacccct cccaaagcaa tcataaacaa atgcctgctt ttcatgctgc 3456661 gctgcaattc atttttatga ttctgcatca tccttccccc tttggttctt ttgccgtgat 3456721 ggtcatccgg tagctttgca aaagatgaac ggtggtttgc tgtatgagga gaggcaatac 3456781 atgaaatgtg tacggtttat agactcgttc tgtccattta tggccgtctt ttccgtacac 3456841 gcccatatta atggatggaa tattcagctt gcgtatgtct ttgaacggaa tggtcccaat 3456901 catattccac ccagggaagt tcctgataaa agaatcaatt tcgccatcgg tttcgtgcag 3456961 tgataaaaaa ctgccgtctg ccaagtaggg gaaaaacttt ttgaagacaa atgtttcgcc 3457021 tgtcgattca gcggttttgt cagccgcttc tttaatcaca tgctgcaaaa gctgatctct 3457081 tgcgctatct tctttcaaat agttatgcgg caggtaagga ggtgcgtaaa atagaatgac 3457141 ttttgcgcct tgatcggggt caagcttttg aagctcttcg attgcctgaa agcatctcat 3457201 gcgaagttca aggtgctcgt tggctttgaa tgtctgctcg atacactgct cgggatctat 3457261 tccccggttt ctcagctttt ctaagtattg ctccaggcta tacacttgaa tgccccatga 3457321 taaatgtttc tttggcaggt tggctctttt tacatattct tcgtaataat ctgataattt 3457381 ttgttctgtc tcccggcatg cttcctcagt gacttcaata agcaaatcca tcatttcttt 3457441 tgctgttctt tcataaataa aacaattgaa atacaagctg gtgctgacag ccgtttgcac 3457501 attataggat tccttgttat cacgctgata caaacaggat gggggcagaa ccaactcccc 3457561 ttcaaccttt tctgccagat ggatgttatt gtggagacgg cttgtgattt cagatgaaat 3457621 gaaatttggg tcaatccctg ccagtgtatc gccaacatgg acttcacgcc cgtaaatgta 3457681 aaagcaaggc aacagttttc ccgcggctcc ggtatagata tatcttgtct gatcaccatc 3457741 gtaaagcggg gtaataaaat ccgtattaat agcagccaaa tagtgaagct gtttttcttt 3457801 ttttagccgg ttcagctctg aaatgctggc gagaatgccc gaatgctggc tctcctcatc 3457861 gggattggcc ataaacaata catttcccgg caacgtctca aggttctccg aaaaatgcag 3457921 gagattggct aaatgcacgg cgatgccgct ttgcatatcg acagatcctc ttccgaacat 3457981 ccactcgcct gatttggcat cccgctgaac atcctgatcg aactcatagc ggctgaaata 3458041 ctcggccaat ttctcacaat caaaagcgat atcctttaaa gggccgaaat cttcaattcc 3458101 aactgtatcc agatgggcat ggtaaatgac tgtatttcgg ctttctccat gtcctttaat 3458161 aaacgcaaaa atatttttgc gtttgtatgg gtcattggga atggcctgtt cccacacatg 3458221 actggggttt tcctgaaaat aaggatagct cgtgatcact tctttgatga aatctgcttt 3458281 tgtcccttct ccaacggtgc cgttcacgct gctgaggctg accagagatg ctgtcagcgc 3458341 ctccactctt tcagccggat tcatgtgact gatttttgta tactgcataa attgtcctcc 3458401 tgatcaaaaa gttgaaatcg tgcgatccgc taaagaatcg cacgatttta tttctctcaa 3458461 atcaaaaagc ttcggacgtt gttttggctt gcatatgaag aattaagtaa tcgggaccgc 3458521 ctgcttttga gtctgttcct gacatattaa aaccgccgaa cggctgatag ccgacaattg 3458581 ctccggtaca tcctctgtta aaatataggt ttccgacatg gaaatcctcg cgcgcccgtt 3458641 caatgtgcgc acggtttttc gtcagaagcg cacctgttaa tccgtattcc gtgttattgg 3458701 caatctccag catatgatcg aaatcacgcg ctttgcaaat cgcaacaacc gggccgaaaa 3458761 tttcttcctg catcaagcgg gcgttttcat caacatctgc aaagatcgtc ggctgaataa 3458821 agtagccttt tgaatcatcg ccttctccgc cggccaatag cttgccttca gatttgccga 3458881 tttcaatgta tttcatcact ttgttgtagg atgcttcatg aatcacggga cccatatacg 3458941 tatcaggatc ttctggattg ccgacagtca gcgttttggt cagcgccaca gctttttcca 3459001 ccacttcatc atacacatcc tgatgaatga ccgcgcggga gcccgcagaa cacttctgtc 3459061 ctgaatatcc aaatgctgaa tacacgatag aggatgcagc aaggtcaaga tcagcgtcct 3459121 tgtcgacaag cactgtgtct tttccgccca tttctgcaat tacccgtttg agccattttt 3459181 ggcccggctg cactttggca gctcgctcat aaatccggca gccgactgca cgggaacctg 3459241 taaatgagac aaaccgtgtc ttcggatgct caactaagaa atcaccgatc tccgcaccat 3459301 ctcccggaat gtaattcaga acgccgtttg gcagacccgc ttcctccatg acctcgacaa 3459361 attttgctgc cactaccggg gctgcgtcag ccggttttaa gagaatcgta tttcctgtca 3459421 caatcgctgc caccgctgtt cccgccataa tcgcgagcgg gaagttaaat ggagaaatga 3459481 cgatgccgac gccaagcgct tcgtaatgat attgattgac ctcgccagca cggctcttca 3459541 ccggagcccc ttccttgagc tttaacattt ggcgcgcgta gaactctaaa aagtctatcg 3459601 cttcagccgt gtccgcatct gcttccttcc acggttttcc tgcttccttc acaagatagc 3459661 ttgaaaattc atgctttctt ctgcgcaaaa tagccgctgc cttaaagaga atatttgcgc 3459721 ggtgctccgg tctttgtttt ttccaggaat caaatgcctg caatgcggct tgcatcgctt 3459781 tttcagcaag ctcttgatcc gctgtagacg cgtacccaat gatctcttct ttatttgccg 3459841 ggttaataga aatgattttg cggtccgttt caattttttc tccatttatg acaagcggat 3459901 aatgcttgcc gagctgagtg tttacaaagg ccaatgactc cccaaatgca gttttattct 3459961 ttgcttccgt aaaatcggta aatggttcgt gcgcgtatgt gactgtcata tgtagtcccc 3460021 ctcgtgttat gaaatatatc ttcgcatatg aataaaaatg caagaatcat gccattttct 3460081 tgtcttttgc tgaaaaaact tgttgaatcg aacagaaatt tgtctaacag gtgatcacct 3460141 ttctcttttt ccgatcttga acgcaaattt attttgcgtt ttttgctctt tacgcaaaaa 3460201 acaaatgcaa aattattttg cggaggcttc tcaaattaga cccatccgcg gaaacgcgat 3460261 gcttctgccg attttctgat gcccgtcatg taagccgcca aacgcatatc cactttatgt 3460321 gttgccgctg tttgataaat tgtttcgaac gagctgacca tgacgcttct cagtttttct 3460381 gcaacctctt cttccgacca ataatatcct tggttgtttt gcacccattc aaaataagaa 3460441 accgtgacgc cgccggcact cgctaggata tccggcacaa gcagcacgcc tctttcattc 3460501 aggatcttag tggcatcaat ggttgtcggg ccgttcgccg cttcaacgac gattgacgcc 3460561 tgaatgttat gtgcgttttt ggctgtgatt tgattggaga tcgcggcagg cactaaaata 3460621 tcgcaatcct tttcaagcag ctcctcattt gtgatgacgt cagtaaataa attggtgacc 3460681 ataccaaagc tgtcccgttt atcgagcaaa taagggatat caaggccgtc tgggttgtag 3460741 agcccgccat tggcatcaga aatcccgatc accttcgcgc ccgcatcgtg catgaatttg 3460801 gccaggaagc tacccgcgtt tccaaagccc tgtatgatga tgcgcgcgtt ttgcagcttg 3460861 atcccttttt tcttcaccgc ctcttcaata caaatcgtga cgccctgtgc cgtcgctgtt 3460921 tcccgtcctt gcgatcctcc caaaacaagc ggtttacctg taataaagcc cggagaatcg 3460981 aattcccgca gccggctgta ctcatccatc atccacgcca taatctgcga attggtgtac 3461041 acatcgggag ctggaatatc ctttgtcgga ccgacgatct ggctgatggc acggacatac 3461101 cccctgctca gcctttccag ttctccaaat gacattgtcc gcggatcaca aataataccg 3461161 cccttcccgc cgccgtaagg aagattggca atcccgcatt tgagcgtcat ccaaatggat 3461221 aatgccttta cttcctcttc attaacttct ggatggaagc gaacgccccc ctttgtcgga 3461281 ccgacagcat cattgtgctg tgaccggtag cctgtgaaca ctttgacgct cccattgtcc 3461341 attttgaccg gaatgcggac agtgagcatt ctctgcggct ctttcatgag ttcatacata 3461401 tctcccggat aacccagctt ccgaagggct tccttaatga ttgtttgggt agacagaaat 3461461 aagttaagag cttctttttc ttcatctttc gagacttgct ttgctgacat ctttttcacc 3461521 tcattgtttt tttggccggc tgtaatgtaa gcgctttaaa aaatcagccc gccaattcct 3461581 ttcttcattg gattcaccct tatcatcatg caagatccgt accagctttt gaatccacaa 3461641 aaaaagagac tgaaaacatc tcagtctctg actacaaatc tatcgattaa cggggatcaa 3461701 tcaccagctg cgtttcagca taaaaactgc cgattcccaa accgtttact acatcgcctt 3461761 taatcgtgta agtgcctgcg cgaggaagag ttttacgcac catgacaagg tcaaattcgg 3461821 atgcgcctaa caaatcaagc gtaagcggga gtctgactgt ttttccatcg tttaaaatct 3461881 gtgtttcttt cagtgttctt ccattcactg aatctcttgt cgtagcatga aacccgtcag 3461941 gaaattgaaa ttctaccgct ccaagagaaa gcaccgcatt tggtttatat gtcacttcaa 3462001 tatcagaaat ggtccactct ttcgtgctgt taactgtttt tgcctcgatt gatgcagact 3462061 gtgcatgagc ttggcccgaa ggaagtaaga ttgatagtaa aacagctgaa ctgatgaata 3462121 atgaagatac gaatgaagtt ctttttagca tgacatttcc ccctaattga ttgttgaaat 3462181 ttggccagag cgtcctctgc agaaaaagcg ctttttcata attcgcgaat taccagttct 3462241 ttttcttaaa aattaatcta tcatcatttt ccatggaagt aaatgttttt taaggaatat 3462301 taacacttgg aattcaatga gaattccttc ctgtttatac aaggttcaaa tggacgattt 3462361 ccctctcttt ttctagtaac atctgcctga cattttatat cttttatcct attttaaaaa 3462421 agggcaaaaa aagtcgaaga tgcctctgct cttcgattga tcacgttcct atttttatct 3462481 gaattcagtg ttccagttaa aaccgatcgt ctcatcatcc cacggaattc ttttttcatc 3462541 aggctgatcc gggttatacg acatggtggt aaaatagata attgtcagcg gcgtctctcc 3462601 cagcactcta tatccgtgag ccaccccttt tgggattaat aacagcatcg ggttgtcttc 3462661 gcccatataa tagacgtccg tttctccttt tgtctttgaa tcctctcgaa gatcgtatag 3462721 gacaacctga gcgtggccgg ttgggaagaa ccagagatca tcctgcttct catgataatg 3462781 aaatgcctta atcacacccg gatagctttt cgaccaagag gcctgcccaa aatgctcaag 3462841 gagattctca tcgtcccgga ccagctcagc aaaaaagcct ctgtcatcgc tatgcttcat 3462901 caattttttc accttgactc catcaatcac acgcactgct cctttcctgc aaatactctc 3462961 gtaacgcttc ccgccagtgg cgggggcgga tgccggcttc ttcaatagcc cgatggctca 3463021 gcacagagta tgccggacgg ggcgttttgt tcccgtattc ctctgtcgtt acagacaaaa 3463081 tggctgtttc cagcccgctt tcttccataa ttgccgtcgc aaactcatac cagctgcata 3463141 tgcctgaatt gctgacatga tagatgcccg gcggatggct gaacagcttg atgaccgctt 3463201 ctgctaaatc cttcgtataa gtcggcgaac caatttgatc gctgacaacc cgaagctctt 3463261 gtttcgtttc agcaagtttc agcatggttt caacgaaatt actgccgcca tgtccgtaca 3463321 cccacgatgt cctgatgatc gtgctgtctt ttgtcgttaa tcgtatcagt tcttctccga 3463381 gccttttgct tttgccataa atggttttcg gatcgagggg atcgtcttcc ctatatggct 3463441 gggttccttt cccattgaat acatagtccg tgctgatatg aacatattga gctccgatgc 3463501 gggttgactc aagcgctgta taataagcgc cgattccgtt aatcaagtac gctttatcaa 3463561 gctctttctc gcattgatca accgacgtaa acgcggcgct attgaccacg atatccggct 3463621 gataatggcc aaacgaatgc cgtactgagc gctggtcagc aatgttcatc atcttctttg 3463681 ttaacgcaat gacctcatat ccggcttgct tcagctggcg gcatagttcc aagccaagct 3463741 gtcctcccgc cccagtcacc aatacctttg tcaatcagat caccttctca tcggtcattg 3463801 tctgtatacc actgaatcgt acgcgcaatg ccttcttcaa acgtcacttc ctgccgccag 3463861 cccagttcgt ttttcagctt tgatgcattg atcgcatagc gccggtcatg cccttttcgg 3463921 tcttccacgt gggcgaacaa ttcctcacag cccagatgct tcaaaatgac actcgccagc 3463981 tctttattcg tgcgttcatt tccgccgccg atgttataca cctcgccgtc ggtccctttt 3464041 tctaaaatca gcttgatcgc gcggcaatga tcctccgcaa acagccagtc tcggatctgg 3464101 agtccatcgc catacagcgg aacaggcagg ccctgcttcg catgacggat aatcgtcgga 3464161 atcatttttt cgctgtgctg ataaggtccg taattgttgc tgcatcgtgt aatgatggcc 3464221 ggaagcttgt gggttttcac ataagacaac acgagcaaat cagagcttgc tttgctggct 3464281 gagtatgggt tattaggaga aagcggcgtc gtttctgtaa acgcgggatc atccgctttt 3464341 aaatccccgt atacctcatc tgttgaaata tgaatcagct tcttggcttt tcctttcaag 3464401 accgcttccg ccaatcggta tgtccccatg acatttgtgg tgataaacgg ctccgcttgg 3464461 gaaatgcttc tgtccacatg cgattctgct gcgaagtgaa tgacgccatc gtaggtctcg 3464521 tcaaaagcgc ggtcgatatc ctcctgaacg ctgatgtccc cttttacaaa gcgaaaacgg 3464581 ctgttttgct ttaatttttc catttcctcc gggtggctgg cgtacgtcag tttatctaaa 3464641 acggtaatgc gcgcatccgt ttccctcagc atgagctttg taaacgtgag cccgatgaag 3464701 ccggccccgc ctgtaattaa atatgatttt gccatcactt ttcgtcctgt cctttccgta 3464761 aagcctggtg tacaagctgg gaagcgagat aaagcgattc gtgagttccg gcatctaccc 3464821 accagcctga taacacatca tacgtaagct ggctgttttc gatgtataga ttattcacat 3464881 cggtgatttc cagctcgccg cgctttgatg gtgatatttg ttcaatatat gaaaacacct 3464941 ctgcatcata catataaatg ccggtaacac aaaggttggt cggtggctgt tcgggctttt 3465001 cgatgatgga acgaatccgc ttgtttttct catcaatctc agcaatcccg aaacgttccg 3465061 ggtcatcaac ttctttcaga agcacttttg ctcctttccc ctgctgttca aagcgttctg 3465121 tataaggctt taatgaatct tcaaatatat tatcacctaa taataaaatg aaagactctt 3465181 ttttcgtaaa gcgctttgca taagacagcc catccgaaat gcccgatgct gccggctgta 3465241 cttgataagt gatagtaacg ccaagctctt ccccgttccc aagcagtttg taaaattgcg 3465301 gcatatgctc cttttggctg atgagtaaaa tgtcttttat tccggcttcc tgcagcttca 3465361 taatcgacca gtatatcatc ggatacgggc ctacaggaag caaatgcttg ttgacggctt 3465421 tcgttaaggg cataaggcgt gagccgtttc ctccggctaa aataacacct ttcacattaa 3465481 cacttcctta catgcatttt tatatctctt gttcatataa atcttgaaga atagctgtta 3465541 cccgtataat gcctttgcca tccacgagcg gccttcctcc cttgtgcaaa gaaaggcgaa 3465601 gaggatagct gctcataatg cgtgacatct gatagatgag tgtttcatcc ggtacaagct 3465661 cacccaatcc aagatcaaga gcggcgcctt ggtcagcaaa tgttttggct gtagccgttt 3465721 gatgctcaac ctgagaaaga acaaggcacg gcacgccgat gcaaatggct tcatatagag 3465781 agatgccgcc agcgacaatg gctgcgtccg cttgtttcat caaacctgcc atatcatttg 3465841 tctgttcgat catcttgtac tgcggcttct tttcgatccg ccttcggact gcctcttgat 3465901 gcggtgaagc gctccccatc acaaacatca tgtttttgtc ttttatgtcg gggacttgat 3465961 cagcggcagc cagcacttta aaaataagct gcttcggatc acttcctcct aatgcaacaa 3466021 ggatattgcg gcagtctttc ttaagtgtgt aatcctctct tgcggcctga aaggcggggt 3466081 gaagaataag atagtccgga ccttcataga tgcgtgtgtt tccctgaacg tacaccctgc 3466141 ttctgatgtc accgtaaatt ccgttaatga ctgcgtcact atattgaatc gatttaccgt 3466201 ttttctcttc aaaaagaaca attttcgcat ctgtctccgt ctttattttc tttaacagct 3466261 ctgcaggcgc gcctagaata tcaaacaaaa gcaaatcaag cttcttgctt tttatttccc 3466321 ggagaataaa ttcgtgctgc tgcagctccg gctttacgat gacctgccaa tgctcttcat 3466381 gaagaaacgc ttcagaatcc tgattcgtat aaaacgtaat caagcatcgc tgtttgagcc 3466441 cctccgcaag cctcttcatc cggacaacat ggcccattcc cttttcatag ccgccgtctg 3466501 cgaagatccc aacatgcatg gctagtcagc ctctcgttcg gttgccgcat cggggttccg 3466561 gttcagaagg gtgataagct ctgaggcgga tacatcgggg cgctcgcctg ctttttgata 3466621 gagggccttt atcgattcat agtcttcctt tgtatcaatg gtcagccgat attgaggggc 3466681 gcgaaatcgt tccggcgcct ctaaaaactg aacacgataa agagctggat gattccttat 3466741 atataacgtg acatgctcct gatattgatc ctccaaagcc tgaatacggc tgatgtcaat 3466801 taacaggttg gcgttgacca cttcgccgca aatccctaat ggggcattca ggatatacgt 3466861 ataatccgag ccttgatcaa aatgcgcctg aatcattaca tcgagcagct caggatcgac 3466921 aaacggatta tcacctgtta accggatgat gactgacggt ttaacagctt ctatgacctt 3466981 cacaaaccta tcgaggacac gttcttcgct cccgcggaaa acacgaaagc cttgtttgat 3467041 acagtgcgcc tctaatatgt cgtcagtttc tttgtcagac gtggcgatga caagattatc 3467101 ccgatccttt tggtaaaacg cgctttgccg gacacggtga acgagaatat caagtaaacg 3467161 attcgatccg agcggccgaa gcacttttcc cggaagcctt gttgaaccca ttcttgcttg 3467221 aatgataaag agaatatcat tcatgaaacg ggctgtcctt cagtaaaatg tcatcccaga 3467281 caatgcctgt gtcggctgga atgtctctta cagcccgaac accgctggtc agcagttcaa 3467341 aaaatctcgg gtgcagcccc tgcggctttt gtccgggccg aagcactgcg atattgtctt 3467401 cactaaaggc ttcacctttt tgaatcggag ctgttgtaaa aatgcctctg tatgcaaagt 3467461 ttctgatttc tccttcgatg gcggtcgttg ttttgtatga actgccaagc agtttttcag 3467521 agaccggctt tgtgatcccc tgtttcagct cagcttccgt tttcctgatg ccatcgacca 3467581 tttctttcaa ttcatccgga tttaatgcaa acgagtggtc agcacccggc agatttttat 3467641 cgatcgtaaa atgcttttct atcagttttg ctccgagccg aaccgcggca cacggcgctt 3467701 ctgtcggatg ctcgctatga tcggagaagc cgattaccgc ctcaggaaaa gcggcggcaa 3467761 gcatcggaat gacgctgagg ttgctgtact ccggcggtgc tgggtatttc gccacacaat 3467821 gcattatggc aatttgattg tttccctctg ccctgatggt gcgccaagct tcgtgaacat 3467881 cagagatttc agctccggct gtcgagaaaa tcatcggcct gttcagccgg gcgacatatt 3467941 taagcagcgg gagatggtta atttcatagg atgcgatttt aaaagcgctc ggcgaggtag 3468001 actgaagcag atcagctgac ccctcgtcac ataccgtact taaaaagatc acctgctttt 3468061 cgcggcagta atccaatagc ggtaaaatcc actcagcagg catttccata gattgaacca 3468121 aagaaaaaat agagacgtcc ttgcccgctg ccgtcttgta caaaccagga tctttctggt 3468181 acatcctatc agcttggaac atttgaaatt tcacggcatc cgctcccgct tccgccgcgg 3468241 cgtctatcag cgcaaaagcc tgatcaagct tcccgtcatg attaatcccc gcctcagcaa 3468301 taataaaaac aggagcgtct ttgcctacag ttttattcgc gatctgaaac gctgccatta 3468361 tttcgcctcc ttgcccggcc aaatatgata atagtaatac gattgttcag cggtgaagcc 3468421 cattcgttca taaaggcgga tcgcccttac attgtgaagc tgcgtccccg ctgttaccgt 3468481 tctatgcttc tgggtctccg gttgttctat gagattcgcc aataaatgaa acgcaatacg 3468541 tttcccttca aatcccggct ttacagccat caaatcgaga atgcactcat catctcttga 3468601 taagccctga agatagccga tgacctcgcc attgtgttta gcgacaatat tgaccgccgc 3468661 ccttccattc agattgtttc gtgtccactc ctgaaatatt tcgtttgctg catcgcggct 3468721 gagatgagga tcctgaaaat atctgctttt tgtaaacgag tctcgggcca gctcacatat 3468781 cgcttctgtg tctccgggct caggcgggcc cagttcaaaa aatggcggtg ttttgtcata 3468841 aaaagacgga ggcatcgcca gcttcagcaa actcccgaca aagtaagagg atggctgctg 3468901 ttgtatcaca tgcgcggctc cgatatcttc agccggaaca cggacaaaga taaaatccgt 3468961 ttcatccatt tggcgtacag tataaaaagc ttcaaacagc ctctttagct gcccggtact 3469021 atttgccgca agaagtttga cgttcatgac tttcttctga agcaccttgc tttcccacaa 3469081 agaatcttcg taaagcaata cgccttggag cctgctgttt tcaaaaaggc cgagggaaaa 3469141 ttgatacgga acatccaatg taagctttct gctttggaga aattcctcaa ttgcctcttt 3469201 ggagacattt tcttttaccg tatacactta atcagcccct tttacgatat cccgcacagc 3469261 ttcaatgaca tcatctacat catcgtcaga cattgatgga tagagcggga gagaaagggt 3469321 tcgtttatag taattcatgg cattcggaaa gtccgcttcc ttatatccaa attgcttttg 3469381 ataatacgga tgaatgtgta ctggaataaa atgaacgcta gtgccgatat tgtattcatc 3469441 ctttaaagcc gtaatcattt cgctgcgcgt aaccccggcc tttttttcat caacttgcag 3469501 aacatataga tgccaggcgt gcctgccgtc atcatggaca aacggcgtga tcagcccagg 3469561 aatctgctga aaagcggttt gatagcggcc ggcaatctct tctctccgtt tctgcatatc 3469621 atccagccgt ttcagctgat gaagtccgag ggccgcctgc aaatcaaaca tattcatctt 3469681 atagccgggc gattcgactt catagtacca gctgccattt gaagaataac ggttccatgc 3469741 ggctttactc atgccgtgaa ggcttagcac ccgtatctta tcggcaagct cctcatcatc 3469801 agtcgtcagc atgccgcctt cccctgtcgc gaggtttttg gtggcgtaaa agctgaatgc 3469861 cgttgcatcc ccgatagaac cgatcattct ttgcttataa gtcgtatata ccgcatgtgc 3469921 cgcatcctcc agcacgaata aaccatgatt ttgggcaaca gccaatattg catccatatc 3469981 gcaggactgc ccgccaaagt ggacgggcac aactgctttc gttcgcggtg tgacggccgc 3470041 ctcaagcttt accgggtcaa tattgagcgt gttttcgtca atatccgcaa acacaggcgt 3470101 cgctcccgta tgaataatcg tattggcggt cgagctgaac gtaagcggag aggtaatgac 3470161 ctcgtccccg ggcccaatcc cttttgcttt caaagccaaa aataaagctg cggtacatga 3470221 attcaccgcc acggcgtgct tcgccccgac aaacgcggca aactcttttt caaactgctg 3470281 aaccttcggg cctttagaga gccatcccga ttcaagcgtt tctgtaacct cctgaatttc 3470341 ttccttaccg attaacggca atgagtaagg gagaaaatga tttctctttt gcaccatttc 3470401 tttgcgctcc tatcatttta ttcagtatct tcccgcctgt aatcaacccc tgttttggct 3470461 ttcagttccg caaataaagc atttgttgat tctgccaccg gataattagc cgctatgaat 3470521 gccaggcgcg cctcttctgc tttttgatgc acgtcgggac ttcgaagaac ctcaaccaag 3470581 gtgtgcgcca gttcatccgg ctggtcaaac ataaaatcgc caagagactc ataatacgga 3470641 tacgagcgat ttccggacga ttttcctatc agcacaggct tttgaaacag catggcttca 3470701 agaccgactg tcgaggtttg cgtcactgcg gcatcaacat acggcagcaa atcataaagc 3470761 tccagctcct ttttgatgac tctgcatgct tgatgttttt tcgccgcctc gtgatacaga 3470821 tcaagcttgt tttttccgat ttcccacggg tggggtttga taatgatttg cagctgcttc 3470881 tgatcagaaa gcccctgcag cacaccggaa taaaagtctt ctgaaaaggg ctgagtggca 3470941 atgagcacaa tttttttagt cggctgaaaa gcaagttttc gatagaatat ggacatatcc 3471001 ataggcgttc tgttaaaaat ctgatcgaag cggggatgtc ccgttacgag aatctgctcg 3471061 ggtttacagc cttttcgtat gaaccactct gcttcatacg caccaaaaac agcttgatag 3471121 gttgtaaaaa caggaatgaa ggcttcatct cccatcaatg cgccatgctg aagacaaatg 3471181 ctgacggccc cttttctttg acacatgaga gcgagcaccc tgctgtaaat gtcttctgcc 3471241 gttccgacaa taacagctga aatcttttcc tgttcaaaca gcgcatcaac tgtatcaatg 3471301 gcctctataa ataaaggaat atctttgaaa agccggtcgc gaaacgcttg atcaccaaat 3471361 gccgggtgat catcataagg ggcgagaagc gaacaggctg tttcgagata ctgcttcgaa 3471421 tcgccttttt ggcatgaatc cgcaatctcc cgcttgctaa ttacaggcag atcacaataa 3471481 tgcggcaaac tccatctggc caaaacagcc gttttttcag gatcaaattg atagtaattt 3471541 tcgtttgaaa aacgcaggta atcaaagtgc aaaatgactt tccctttaac aggttcgtca 3471601 tttgttttaa cgatgttttg gattctttct tcaaaaaacg gctgaatctg tccctcatcg 3471661 atatgctgat ccaccgatcc gaataattcc ggttcttctt ccatcatcac cctcagttca 3471721 gggctgatgt attgataaaa attactgata agcccaagcg gaatcccttt gtagcgaagt 3471781 ttgtcaaaaa gctccacgta cttccggtac agcacccaat aattgcttaa ataggccgac 3471841 aagctctcac cccattccaa gcttttttaa tgattcacgc agctctcggc aatttcgctg 3471901 cggaggaagg ttcctgacaa attcattttt ttctaattca aacagctgaa agtgaatcga 3471961 ttggtcggta atataattca ggtccagctc ctcatccagt gggtaaaacg gataaaaatg 3472021 attgactctc caaaagaacc gggcatctcc tatacggtaa aacgccgggc tttcatccca 3472081 ataggagcca aacttctcct ttaccttctc aagcaccgaa tacctgtgca tcaccgagca 3472141 atgatcaatt gcgcacggcg cgttccatgt cacttgagcg gcaggcctga cagtttcttt 3472201 tacaatgtca cgattctcgt ttaaatgata ggttttggag gctgagtaaa tcacagcctt 3472261 ttcaggatgg gtatcgagct cccgcaccat tttcaggagg cggtccggca tatagatgtt 3472321 gtcatccgtc gcataggtga tatattcacc ctccgccatc tcaatcgcct gattgatcag 3472381 tgccgcgtat ctcgtttttt ctgttctttc cttcactcca gatatatcgc tttgataaaa 3472441 acgcactcgg ttatcattca aaaaaggacg gattacattc agcgtctctt cattggagtt 3472501 gtcatccata ataaacaatt caaaatctga aaacgtttgt gagagtatgc tagaaatgga 3472561 ctttgccaca taatcgcttt tgttatagct cgtcataatg actgatactt taggcaaatc 3472621 ctacacctcc ttcttggaac ttcacacctg aaactatcgt tatcttatgt tgcttatgct 3472681 caagttgcgc tagggataca aaccaatatg cgaaaagttt gtgtatgttt ctgaaaaaca 3472741 gcggctgccc agagcgaaat ctgatcggtc cgctgttctt tttcagcata atccaagcat 3472801 cagcctcata aggtgaaaga gataaaaatc gcaccagcga ctaagatcgt tttccatcgg 3472861 aggtgagtca tcgcggagcg ttcacctata catccagaac atgttttgaa tggttttcat 3472921 aaaaaggagg aacgatatga aaccgaaaaa aaatcaatat cagcaaatgc aggcatttga 3472981 taatatgcag gggtatcagc ctcagtttgg cgccaacccg tacccgcagc aaggccaagg 3473041 ctcacaaatg cagacaatgg ggatgcagcc aatgatgcca atgcagcagg gacagcaagg 3473101 acaacaagga cagcagggat ttggattccc gggccagcag cagggcggcg gttttcaaat 3473161 tccatcgggg cctacaccgt caggaccggg ccaaagcgtt cccggcatgc tgcctgttga 3473221 ggaatcttac atcgagaata ttttgcgcct gaatcgggga aaaacggcca ccatttatat 3473281 gacatttgaa aacagcaagg aatggggctc gaagattttt cgcggcgtca tcgaagctgc 3473341 gggccgggat cacattatta tcagcgaccc gaaatcagga acacgctacc tgctcctgac 3473401 aatctacctc gattacatta catttgatga agaaattgct tatacgtatc catattccat 3473461 ggcgtcctat tcgccaagat aagaaaaaag ccaatcactc atatgatgag gattggcttt 3473521 tttgtttata gatatttgac ggctgcgaca acgatcataa tccaagaaat aataaacgcc 3473581 acaccgccga gcggggtgat cgctccaaga atggagattt gcgtcacact tagaatatat 3473641 aagcttccgg aaaacagcac aattcccgca aacatcagcc agccggctgt cgtgacactg 3473701 cctatgccgg ataatttatc agccagaaac gcgacaacga ataacccaag ggcgtgatac 3473761 atatgatact gcacgcctgt gtgccaaacc tgaagatact tatcaggtat tttcccttct 3473821 aatccgtgag cgccgaatgc tccgagtccc acggcaagca gggcgttaat ggcccctaat 3473881 atgataaaaa ctttcatcta tctctcccgc cttttcgtta aactcatatc atttatctta 3473941 tcgcacctgc accaaaattc aatgtttgtt ctccgttgac acgagattgt cggattttct 3474001 cctgcgccaa agctggaact ggtcagctgc tattgcagca agcgtcccta atacgagccc 3474061 gttgcttaat agagaaataa ataccggatg caatcccttt aacgcagttt caggaacaaa 3474121 catgataccg acccctgtca gcagtgagat accgatgata gacctcaccc tttttgattc 3474181 ttctttctca tatgaatcaa attcggcaaa ggccagaccg cccattgcgg agaacacaac 3474241 aaaattcacc gcaaatccaa cgggtgacgg caggctcgca aacgtattca taaaaaacgg 3474301 gatcacgctg atcacgataa ccagaatact gccgagcata aacggttttt tagaaggcat 3474361 cttggtcgtt tcaataaaac ctgcggctcc cgaaatcgga acaggcgcaa tagctcccgt 3474421 caaaccgcta agcagatggc tgaatgaagc tgcaaaaccg gcatggcgtt catgatgctt 3474481 tccatcaggc tgtttgctga attttttcat ggcgatgtcc acgaccttca tgctcgccag 3474541 catattcacg atcagcaaga tggtaataaa aatagaagtg atgatcaggc cgctgttaaa 3474601 taacggggtc ccaaaaggaa acagggaagg cagctgaaac agccggtccg gcatttcaat 3474661 cggctttgcg gctccggcag ccgcaaacag cacccacccg ccgaacaagg ctaataaaat 3474721 agaatattgc ttaaaaaaca tgatgttcga atttgtcatt ataaaagcgg cagcgatcac 3474781 aacaagcgcc aggccaaata caagaccgtc caccccgtcc tgtcgataac cgattccgag 3474841 aattcctttt ataatgggct gactcagctg catgacaaga agcaataaat agacgcccgt 3474901 tacaaccgga gtaaacaatt ttgcaagtct gtcaatgacc ttgaaaacac ttaacaaaaa 3474961 gaaacataca gcgcttacaa gaagagctcc ctgcaaaccc cgcagtgtgt ctccatatgt 3475021 cgcaaacaca gttcccgtca gccctgcgta aatcgtatac actccccacc acaagccggc 3475081 tgggctttca ttgatcggca gtctgtggcc tttcaaacac tgaatgacgg cggcaattcc 3475141 cagtacaaaa aaagtgcttt gaatcaatct tgcagaatct gagtgatcca gatgaaacga 3475201 ctgggcaacc gccaccggaa caacaatcgc cgcagcaata ataaacgctg tccattgcag 3475261 cgcgccaaga accaatttca cgtaagctca acctctctct ttaaaaatca aataaagact 3475321 ctccgtttcc atcctcttcc tgcttctctt tttcttgctt tcgatatttg tttaatcccg 3475381 cgctccccat cattttttcc atcatcagct ggtctgtcga tggcggcgcg gcgggacttg 3475441 gcgtaacgct cggctgtatg cggggcgcgc tcgcgttctc cggctgatca agcacgacat 3475501 cacacagaga acggacaacc gctacataac gcttcagctc ctcatcccgt tcagccgttt 3475561 ttgctttttt tagctcttct tccatctttt gaatcaaagc agatatatga atgttcatga 3475621 agcaccctcc aaaaaaataa atgttgtctt cctgcatttt atcaaattcc tgctgaaaac 3475681 gcagatatga gtttgttatt ttttctgaca aaccttgcgc gattgacaag cagaagagat 3475741 ttttcacata ataaatcacc ataccttaca aaaaggagaa acggaatgaa cagcatcccc 3475801 tctatcatca gcaagcataa agcctatttt gcggcgggac atacgagacc gcttgaatcg 3475861 agactgaaca ttttgcgaaa gctgaaacaa gccgtcagaa ctcatgaagc cgatctcata 3475921 gccgctctct accaggatct ccataaatcc gagcaagaag catactcaac agaaatcgga 3475981 atcgtcttgg aggaaatcag ctttgtcatg aaacggctga gaaaatggtc caagccgaaa 3476041 cgagtcaaaa cgccgttgac tcatctaggc tccaaaagca tcatcatccc tgagccgtat 3476101 ggaaccgttt tggtgattgc gccttggaac tatcccttgc agctggcgct ttctccgttg 3476161 attggcgcca ttgcggcggg gaacacggtc gttctcaagc catcagaata tacgccggct 3476221 gtttctgcta ttctttccaa actcatcagc agcgtttttc caactgatta tgtcgctatg 3476281 gcagaaggcg ggcccgatgt cagcacagca ttattacagc agccctttga ctacattttc 3476341 tttaccggca gtgtagctgt aggaaaaatc gtcatggagg ccgccgccaa acaattaatt 3476401 cccgtaacct tggagctcgg cggcaaaagt ccctgcatcg tccataaaga tgctgacatt 3476461 cagcttgccg ccaaacgcat cgtcttcggg aaatttacaa atgcgggaca aacctgcatc 3476521 gcaccggatt atttatttgt ccacgaggac atcaaaacga agctcacaga agaaatgaag 3476581 cgtgcgatca gagaatttta cggccctcag ccggaacgga atccacagta cggcaaaatc 3476641 gtcagtgagc gccactatca gcggctgctc agctttctga atgatggcat cccgctcaca 3476701 ggcggacaat ctgatcccaa tcatcacaaa attgcgccga ccattctcga acaagtgaga 3476761 gatgactctc cagtgatgca ggaggagatt ttcgggccga ttcttccgct ctttacatac 3476821 cgcaatatcg gggaagtcat tgagaaagtc caatcgcgcc ctaagccgct cgccctgtat 3476881 ctcttcacca caaacaaaga aattgagcgc gctgttttag gaaatctgtc gtttggcggg 3476941 ggctgtgtca atgatacgtt aatgcatgtt gcgacgccgt atttgccatt cggcggcgtc 3477001 ggggaaagcg gcatcggcag ctatcacggg tttgacagtt ttaacacatt cacgcacaaa 3477061 aaaagcgtcg tcaaacaaac gaaccgtttc gacttcgcat ttcgttatcc ttcctccaaa 3477121 aacgggctgc gaatgattcg aaaaatactc aaataaaaaa gcgcagatca cctgcgcttt 3477181 ttacaaatcc ttaatacacc aatcaatcgg cgcctctccc attttctcca aataggcatt 3477241 cgcccgggaa aacggtctgc tcccgaaaaa tccgtttctc gcagaaaacg ggctgggatg 3477301 cgtcgattca atgataaaat gcttggaggt gtcgatccgt tcttttttca tttgagcatg 3477361 ccgtccccac aaaataaaga taaccggccg ctctctttca ctcagcacgt caataattcg 3477421 gtccgtcagt cgctcccagc cttttccctt atgggaattc gcctgtccgc gccttactgt 3477481 cagcacagta ttcagcaaaa gaacgccttg ctttgcccag ctcacaagcg acccgtgatt 3477541 cgggatgctg cacccgatgt cctgctgcag ctcaagaaag atatttttta acgaaggcgg 3477601 ctgctttaca ccgggcttga cagagaagct taaaccttga gcctgtcccg gcccgtgata 3477661 cggatcttga cccaaaatga cgaccttgac atcatcatat gatgtataat gcagcgcgtt 3477721 gaaaatatcc cggctgtccg gataaatcgt ttgctccgcg tattccctct tcagcatctc 3477781 tctgagctct tgataatacg gtttctcaaa ctcttccttt agctgattcc accagctgtc 3477841 ttgtaaaagc tgtttcaaga ttcaggcctc cttacgaacg atgaagtctg gaatagacag 3477901 gctcgccatc ccaaaccatt tcactttttg cttcccgcct cttcatctca ggctcttcaa 3477961 gcaggacggc aaagtttttc gtcggcagct ccccgagtcc gtgcttttca cttaaacgat 3478021 ccaaatattg cttccgcttg gcgccaaggt cagcagactg attgtctccc gcgtcactga 3478081 aggcataaat cacgctggcg caagggacac gcttcacccg gtaatccttg gccgcgcgca 3478141 aataaaaatc ccagtcccag taattgtgca catcagcatc gaaatacccg atttcatcat 3478201 gcagaaaacg tctgtacatg ctgcccgacg gcacgtatgt agaaaacact ctcatatcct 3478261 catagtcagc ggtataagca aacaatttcc gtgacactgg ataccttgtt ccgtttttct 3478321 cttcaaacga aactatttcc gcatcagaat gaacgaagtc tgccgtttct atttcctttg 3478381 ccattttctc gatatgccct ggcgtaaaga aatcatcgtc atcacacagc ataatgcaat 3478441 ccccagacgc ctcttttaca ccggcatttc tcgcagccac atgccccgag ttcttttcta 3478501 aattgatgac agcaatcggc agctccggat aaagtgcttt gaccggcacg accgattccc 3478561 cggcatcatt cacaataata atttcatacg gcatcaaggt ctggcgggaa atcgactcca 3478621 aaagctcaca caaagccgga atccgattat aggtcacaat tacgatagaa atcttcatga 3478681 tgctctcctt ctcattttca tagtcatgta ctattaaaac atatattgga cgggagatca 3478741 gtgggaatat cctactgaaa cggcatacta caatgataga aacagcaaag tggctccgat 3478801 cagaagcacc atgatcagca tcagatctcc aaagacatga aagatatctt tcatgcggac 3478861 gccattcgga aggataagac gccacagctt agattgatag accggcagca gcaccagtgc 3478921 ataagaaaga cacaaaaatg taaaagccgg cggcacaaaa gcacagcctg catcgtccca 3478981 attcatcatg atgtctttca tactagatcc atccaataaa aacaaagata tcatgagggc 3479041 tagcaacaca aaggacccca attgaacctc aaacaggcgc attttctggt tatatgcaaa 3479101 tcggaccgcc caaaaccaga cataagcata tgaacatagc agcgtaagaa tggcacctgc 3479161 tgtaaagacg acatcaggca gccgatcaag cagaaaaaca aaaggcaagc tggctgccat 3479221 agccaagagc atgcagccac cagtaaacaa aaatactgcc ccatgagcta caaaaccata 3479281 taaacaagag ctaatcctca cgacatacac ctcctttaca tagaaattct atgtatatac 3479341 ctaaaaaatc agacaagctg acgcctgcca atataacagc ccattcggcc aaataacgga 3479401 aataacagcg ttgcaaaagc acaagttcca acaaaccaag gtgtcaacaa ggattgaaac 3479461 agcgcagcag gaattacatt gaatagaaaa acaagcataa aaatgacgtt tggcaccatt 3479521 gagatcagaa tcgtatgtag aacaagcttt tctccgcgtt ttccaaactc cttcacgcct 3479581 tgatacccaa tcagcaccca gtagatcata tatgcagcta agatcagcca aacagaaaca 3479641 gaaatgcctt tccatactgc ttgaacaaac ggtgattcaa gccatacatg cattattgta 3479701 atcgcaatgc cgacagcgaa tagggcactg ttacagaaaa gatggaacat caaaaacgca 3479761 cgaaacgtta ctggctgtat tttcttaaac gaagaaacaa tgtcagttgg tgttccaaac 3479821 gcctgcaata aagtctgcat agcttcctcc tcactctttc cttcctgaaa agagcgaaac 3479881 agatgatgtt caatatggct ctcaatctct tctatcatcg cctcaccctc aggaagccct 3479941 ttaagcccgc ttttgatttc ggatacatat gtttctttat ccattttgtc cgctccactt 3480001 cagtattcgg tccatcatgg ctgaaaatac gctccattcc ttcgtgcgtt ccgccagcac 3480061 ttctttgccc tcgtctgtaa tccggtaata tttgcggtcc ggtcctttct cctgcttctc 3480121 ccagtaggaa gaaatatacc cttggcgttc aagcttgtga agagaaggat acaaggtccc 3480181 ttctttcatc tgcagttcat ttccgctgcg gcttcccatt tcttttacaa gctcatagcc 3480241 gtacatcggc cgctcgttca gaagcgtcaa taccaatata accgtgcttc ccttaaccag 3480301 ctcacgattt aacatctcaa aacccctacc tagttttctt atgtagcatt ttacgaaagc 3480361 ccgttgagat tgtcaaatga ttcctataga tcttctatat tgtgatacag agaaaatcta 3480421 actataatga aagacaaaac atgatggagg ttcaagacat gtctatgcat aaagcactca 3480481 ccattgccgg ctcagattcc agcggcggtg ctgggattca agctgattta aaaacatttc 3480541 aagaaaaaaa cgtatacggg atgaccgcct taacggtgat cgttgcgatg gacccaaaca 3480601 acagctggaa ccatcaggta ttcccgatcg atactgatac aatccgcgcc cagcttgcaa 3480661 caattacgga cggcatcggc gtggacgcca tgaaaacagg aatgctgcca accgttgaca 3480721 ttatcgagct tgcggcaaaa acgatcaaag aaaaacaatt aaaaaatgtg gtaattgacc 3480781 cggttatggt ttgcaaaggt gctaatgaag tcctttatcc ggagcacgcc caagccctgc 3480841 gtgagcaatt ggctccgcta gccactgtca ttacgccaaa cttgtttgaa gccagccagc 3480901 tcagcggcat ggatgaacta aaaacagttg acgatatgat cgaagccgcg aaaaaaattc 3480961 acgcactcgg cgctcaatat gtcgtcatta caggcggagg caaactcaaa cacgagaaag 3481021 ccgttgatgt tctctatgac ggagaaacag cggaagtcct tgaaagcgaa atgatcgata 3481081 cgccttatac acatggcgca ggctgtacat tctcagcagc cgtgacagcg gagcttgcca 3481141 aaggtgcgga agtcaaagaa gccatttacg cagcgaaaga attcatcaca gcggccatta 3481201 aagaatcctt cccgctaaac cagtatgttg gtcctacgaa gcattctgca ctgcgcctga 3481261 atcaacaatc ataaaaaaag gggctgcctt acagagaggc agcccttttt aaatcaccga 3481321 agacttttca cagaaaaaac tgccgatccc atcggcagcc tgtttatttg atttttaaat 3481381 tgtttgcaga tttcctcaaa aatgtttcta tcgactgaac aaaaagtgca tattccttca 3481441 tttgttcata tgcccgcgtg agaatttccg ccgtttcact gtgcggcgtt gttccgccaa 3481501 gcattttttt cagctgaagc agcacatcct tatattcttc tcgcttatct tcaacttggt 3481561 tagcagcctt ttccaaacat tccggtgtta tcttctgttc atgtatattc aagaaaacaa 3481621 ctccttttac agaaaaaaat agtaggttat cgttgaagaa tagcacagat ggctcagatt 3481681 tcacataaga aaatagaagg attttctaca taagtgtcca aattccgaca ttcatttcag 3481741 atttcccggt cgcactggct gttacttcat gatttcccgg gaaaggaaaa tatcttgcac 3481801 tcaagacctc ttctccgtta ttgataaaga tttccacaga tgacgcgtcg agaaacatgt 3481861 gtacggtatg caaatccttg atgcggcaat gtctcgcttc tgttcttttt ccgtcaaagc 3481921 tctttcgttc cagcgtaaca atcccctcgt ctttatggaa ggaaaacgta gccgttccgc 3481981 ggatactgat tgaaaagcca gactccgtat gaatgtcttc cagtagaatc tcagttcttt 3482041 caggtttttc cactggaagc gcaccagatg atccatgcat gttgatgtgt atttttttct 3482101 catttctgcg catggctttt agctcaggca gcggctgctg aatcagcttc tgtcctgaaa 3482161 gcgtcagctg tctcggcagc gtcatgcagt gaatccagtg gcagtcaatg gtcggatggg 3482221 acccttcatc ctgatcaggc accgccatcc atgcaaataa aatccgcctt ccctgatcgt 3482281 cttcaagtgt ttgcggcgcg taaaaatcaa aaccttgatc aagctccgta aattcaccat 3482341 gcttcagttc aggcttgtta taatcgaggc ggccgacaaa ataacctgat tgatatacgt 3482401 tctgataacg gaaaccgtca gcctcaagcc cttgaggcga aacaatcagc acatccgatc 3482461 cttgaaggga aaacaaatca gggcattccc acatgtatcc aaaatcgtcc agcccgttga 3482521 agcccgcgcc ggttatcggg ccaagaaatc tccactctgt caggttatca gaagcaaaca 3482581 acacagcctg ccctttcaaa ttctctgttt gcgcaccaat caccatatac catgtgcctt 3482641 catgctccca taccttcgga tcgcgaaaat gcgccgtata tccttccgga aggcgggcga 3482701 cgacaccctt tttctcaaag gacagcccgt cgtcagaaac agcaaggcat tgatacgttt 3482761 cccgatttcc atcctgatcc ctgacatttc ctgtgtaaaa aagatagagc cgatcgtctt 3482821 tcgtgacagc gctgcccgag tagcagccgt ttttatcaaa ccaatcactc ggagccagcg 3482881 caatctcttc ccgcttccaa ttcacaacat cctgtgtcgt ataatgcccc caaaattttg 3482941 cgccgtgccc cgtctgaaac ggctgccact gaaagaatac atgatagctg cccttccaat 3483001 aaatcacgcc attcgggtca ttcagcagcc caaccggcgg catgatatga aaatgctggc 3483061 ggtgcggatc gctgttagcg atgggctctt ttttctccac ttcttcataa gcccggcgac 3483121 gaagctcctg gtcatgtgct gtcatttttt cctctcctca tcctcattaa tcttcatgac 3483181 aaatgctgca atgaacgctg acactgccgc aatcgccatg ccaatcagat agtgaatcaa 3483241 gttgctgaag ccaaacggag ccgcaatggc gatcatcgga attcccgtta acccgtaagc 3483301 gtttgcagct acatgtgtaa agacgacata tgccccaccc aatgcgcctc cgatcatcgc 3483361 ggcgataaac ggttttcggt agcgcagatt gactccgaat atgacgggct cagtaatgcc 3483421 gagaaaagcg gaaaatgctg ccggaagcgc gatttctttt gtctttgcct ttttcgccat 3483481 aaagaagacg gcaagacctg ccccgccctg tgcgacattc gccattgacc agatcggcag 3483541 caagtagttt ttgcctatat ctgcaattag ccctgcctca atcgcatgga agctgtgatg 3483601 aacgcctgtc agcacgatga gtgaatacgt gcccccgaaa atcagacctg cgacaaaacc 3483661 ggcatggtca tatacataag ttaaagcaac cgtaatgccg gagccaagcg ctctgcctag 3483721 agggccaatc gcgataaaag caacaaaccc ggtgacaatc acagtaacaa atggtgtaac 3483781 aagcaaatcc accgcatgtg gaaccacttt tctcgtccat ttctctacct tgctcatcac 3483841 atacaccgca agcaggacag ggataacagt tccctggtag ccgagaagag cgatatcaaa 3483901 tccgaaaaga tgcatgtaat caggtgtcgc ttccgccaat ccccatggat ttaaaagatt 3483961 cggatgaatc atgattcccc cgatgaccgc tcccaagtat ggattgctgc caaactcttt 3484021 tgaagcgctg accccgatta gaatcggcaa gaaaatgaat gctgcacttg aaaacatatc 3484081 aagcagctgc aaaagcgcag aatccttgct catccaatga aacgcattga tcatacccag 3484141 caatcccatt aataggccgc tggctacaat agctgggatg attggaacaa aaatattaga 3484201 aagcgttttc gcaaatctcg cagcgggatt cagcttttct tttgccgcat cctgatgatt 3484261 gacgtgttct tcacgctcga tatcagcttc tttagaaaag gcatcgaata ctttattcac 3484321 aaggcctgtt ccgaaaatga tctggtactg gccagagctg ctgaaagccc ctttaacgcc 3484381 atcaagctct tctacttgtg cttgatctat ctttgattca tctttcatca ctaaacgcag 3484441 tcttgttgca caatgagccg cgctgataat attttctttc cctccgagaa gctcaatgag 3484501 gcgttttgca gtctctttgt aatccatcta tttctccccc ttttatttaa acaaaaaaga 3484561 cctaaaattc gccaacgaat aaaggacaca gcgatccttt ttcatttacg caaattttag 3484621 gtcttgcctg ctttaccagt cacaatcccg cttattcaga ttaagaatac gctttcatca 3484681 taaatcatga tagcgttttc gtcaactatt tttttagtta aatagtttga tataacatgt 3484741 agacaaaaat tcgtaaaaat taattgtgaa atacttcaca atatcgtgct atactatgct 3484801 caatcatgaa agaaagcagg aaaagacaat ggaaactcaa gcattacaaa aggttgaaca 3484861 gtatgctttg aaaaaacaaa acatattcgc ttcaagcaaa atccgttatg tgcttcggtc 3484921 cattttggcc agtatattta ttggttttgg cattacagcc gcaagcaaaa caggcagcta 3484981 tttctttatg gctgattctc cgtttgcctt tccggcagcc gctgtcactt tcggggccgc 3485041 tattctgatg attgcttacg gaggcggaga tttatttacc ggcaacacct tttatttcac 3485101 ctataccgcg ctccggaaaa aaatcagctg gcgcgacacc ctatacttgt ggatgtcaag 3485161 ctatgccggc aatttaatcg gcgccattct gtttgccatc ctgatcagcg cgacgggact 3485221 ttttgaggag ccttctgttc attccttttt gattcatttg gcagagcaca aaatggagcc 3485281 gccggcttcc gaattgtttt tcagaggaat gctgtgcaat tggcttgtgt gcctcgcctt 3485341 tttcattcca atgtctctca aaggggaagg agcaaagctt tttaccatga tgcttttcgt 3485401 tttctgcttc tttatttccg gctttgaaca cagcattgcc aatatgtgca cattcgccat 3485461 ctcgcttttg atcgagcacc ctgatacagt gacactgatg ggagcagtca gaaacttaat 3485521 ccccgttacg ctcggcaatc tgaccgcggg aatagttatg atgggctgga tgtactacac 3485581 actgaatcct gatcaataaa aaaacttcca gagatcactc cctgcaagtc aaagcggtta 3485641 ttccgagaga tcttgaagac gctggacatg cagcgtgata tagccggcct cggattccgg 3485701 caaatgtaat tgatattcat ttttcaaaaa ctccgccagc tccagcgcac attgataggc 3485761 gaatgaatac tttttttgga tgaaataaag catctcctcg tccatacgat ggagcgcttc 3485821 atttgattcc aaccggctga ccgcgtatcg caaatgcgtg acaaggcgtt gataggaaat 3485881 gctgttttca tccacctttc gattaaagta ttgttttatt ttctctatca tttctttgat 3485941 catggtcgta tgcttcagcg ctgaatacat gctctccgca tccatcttcg ccgtatggat 3486001 gtgaagggca atataacccg cttcatcttc aggcagagac acgcccaatg tctcttttac 3486061 atgtccgatc gcccacaggc cgatctcata ttctttttta tagagcgcct ttatctcatg 3486121 cagcaattta ttctgcacaa gcagcccatt ttgaatcctt tcgatcgcaa aggacaaatg 3486181 gtcggaaagc gcgatatgaa tgtgatcgct cagcggcgcc gcgagctctc cttccgcata 3486241 gctgatgata tcctcagcta tttctatatg ctcctccggc agtgtttgca ggatttgttt 3486301 gaacttttca ttctcgtcgc gcacgacaaa gatcttttcc actttattca tagggatgag 3486361 atcatttttc tttttttgaa aagcgattcc cggtcccatc acgatttttt cctgatcatc 3486421 ctcttttatt aaagccgcat tgttgtttaa tactttatag attttcaaga ggttatctct 3486481 cccgccaatt tgcttttgac tgggatttta cctccttttg accgccatgt aaagatgcgg 3486541 gcccgctctc tcctgctttg gcgattcctt gaaggcttgc aaacatcttc ttttataaag 3486601 cgcggcggct ttcgctttct gcttttcttc ctcattcaca gccatccgcc attcataaaa 3486661 cgaaacgagt cctgcggcct gcacagccgc ctttctttgg tatgtacgct gagccgaata 3486721 gaccgcggca gccgcagttt ttctgtccgg cgtcacccag ttcatcaaaa agaccatcca 3486781 cacccgtaaa gatacaagca aacgtttcat agaaaaacat ccctccgctt ctttttggca 3486841 ggcagccttt ttagcagccc gttttctcag ccgcagcccg caagaaaaga cggccgattt 3486901 cttttctcgc aaactagcgg ctctagcaaa actcatgact ctatgataga ccgtggaaag 3486961 agaattcttt gtcacaatat gagtgaaaaa accaactagt ttttagaagt tttgttgaaa 3487021 gctgaaagaa ttgaaatgaa aattggagaa ccgctttgaa aactttatac acaagttatc 3487081 ccaaagataa gaacaactta atcacaagag atatccacat gtccacaaac tctatctata 3487141 ttttgtatac gaacgtatat tcctaactat atatatacac aggtttattc acttatacac 3487201 agggttctgt gtataactcc ttcgttatac acaaacaaaa tccaataaat ggtccaaatg 3487261 acacaaggat ttttttgaat tttcaagaaa tatatactag atctttcaca ttttttctaa 3487321 atacaaaggg ggaaacacat tgaaaaaggg gatcattcgc tttctgcttg taagtttcgt 3487381 cttatttttt gcgttatcca caggcattac gggcgttcag gcagctccgg cttcttcaaa 3487441 aacgtcggct gatctggaaa aagccgaggt attcggtgat atcgatatga cgacaagcaa 3487501 aaaaacaacc gttatagtgg aattaaaaga aaaatccttg gcagaagcga aggaagcggg 3487561 agaaagccaa tcgaaaagca agctgaaaac cgctcgcacc aaagcaaaaa acaaagcaat 3487621 caaagcagtg aaaaacggaa aagtaaaccg ggaatatgag caggtattct caggcttctc 3487681 tatgaagctt ccagctaatg agattccaaa acttctagcg gtaaaagacg ttaaggcagt 3487741 gtacccgaac gtcacatata aaacagacaa tatgaaggat aaagacgtca caatctccga 3487801 agacgccgta tctccgcaaa tggatgacag tgcgccttat atcggagcaa acgatgcatg 3487861 ggatttaggc tacacaggaa aaggcatcaa ggtggcgatt attgacactg gggttgaata 3487921 caatcaccca gatctgaaga aaaactttgg acaatataaa ggatacgatt ttgtggacaa 3487981 tgattacgat ccaaaagaaa caccaaccgg cgatccgagg ggcgaggcaa ctgaccatgg 3488041 cacacacgta gccggaactg tggctgcaaa cggaacgatt aaaggcgtag cgcctgatgc 3488101 cacacttctt gcttatcgtg tgttagggcc tggcggaagc ggcacaacgg aaaacgtcat 3488161 cgcgggcgtg gaacgtgcag tgcaggacgg ggcagatgtg atgaacctgt ctctcggaaa 3488221 ctctttaaac aacccggact gggcgacaag cacagcgctt gactgggcca tgtcagaagg 3488281 cgttgtcgct gttacctcaa acggcaacag cggaccgaac ggctggacag tcggatcgcc 3488341 gggcacatca agagaagcga tttctgtcgg tgcgactcag ctgccgctca atgaatacgc 3488401 cgtcactttc ggctcctact cttcagcaaa agtgatgggc tacaacaaag aggacgacgt 3488461 caaagcgctc aataacaaag aagttgagct tgtcgaagcg ggaatcggcg aagcaaagga 3488521 ttttgaaggg aaagacctga caggcaaagt cgccgttgtc aaacgaggca gcattgcatt 3488581 tgtggataaa gcggataacg ctaaaaaagc cggtgcaatc ggcatggttg tgtataacaa 3488641 cctctctgga gaaattgaag ccaatgtgcc aggcatgtct gtcccaacga ttaagctttc 3488701 attagaagac ggcgaaaaac tcgtcagcgc cctgaaagct ggtgagacaa aaacaacatt 3488761 caagttgacg gtctcaaaag cgctcggtga acaagtcgct gatttctcat cacgcggccc 3488821 tgttatggat acgtggatga ttaagcctga tatttccgcg ccaggggtca atatcgtgag 3488881 cacgatccca acacacgatc ctgaccatcc atacggctac ggatcaaaac aaggaacaag 3488941 catggcatcg cctcatattg ccggagcggt tgccgttatt aaacaagcca aaccaaagtg 3489001 gagcgttgaa cagattaaag ccgccatcat gaataccgct gtcactttaa aggatagcga 3489061 tggggaagta tatccgcata acgctcaagg cgcaggcagc gcaagaatta tgaacgcaat 3489121 caaagccgat tcgctcgtct cacctggaag ctattcatac ggcacgttct tgaaggaaaa 3489181 cggaaacgaa acaaaaaatg aaacgtttac gattgaaaat caatcttcca ttagaaagtc 3489241 atacacactt gaatactcat ttaatggcag cggcatttcc acatccggca caagccgtgt 3489301 tgtgattccg gcacatcaaa ccgggaaagc cactgcaaaa gtaaaggtca atacgaagaa 3489361 aacaaaagct ggcacctatg aaggaacggt tatcgtcaga gaaggcggaa aaacggtcgc 3489421 taaggtacct acattgctga ttgtgaaaga gcccgattat ccgagagtca catctgtctc 3489481 tgtcagcgaa gggtctgtac aaggtaccta tcaaattgaa acctaccttc ctgcgggagc 3489541 ggaagagctg gcgttcctcg tctatgacag caaccttgat ttcgcaggcc aagccggcat 3489601 ttataaaaac caagataaag gttaccagta ctttgactgg gacggcacga ttaatggcgg 3489661 aaccaaactt ccggccggag agtattactt gctcgcatat gccgcgaaca aaggcaagtc 3489721 aagccaggtt ttgaccgaag aacctttcac tgttgaataa gaaaaagccc tgccgattcg 3489781 gcagggcttt ttaaagatca gtcagcaaac gcctcctgca ataagcgata cgatcggagc 3489841 ttatcttcaa aatgatgcgt gatggtcacc accatgattt cctctgtttc atacgcgtta 3489901 ctcaaagcta acagccgctc cttaacctgt tctttcgtac caacaatcat tcgatttcga 3489961 ttatcagcaa ttcgtctctg ttcataagga gaatacgtat ttttccgaac agcttcatac 3490021 gaaggaactc cctctaaagg aataccctgc tctcccgcca aaagtgtaaa atcaagcaca 3490081 gccccaagct cctctgcctt ctcctccgtg tcagcacaaa gaacaaaaac agcaactgcc 3490141 gctcgaggcg tatctcctaa cacagacggt ttgaatcgcc tcttatactg tctgacagta 3490201 ccctctccgc cctctccatt gataaaatgg gcaaacatat agccagcgcc agattcagct 3490261 gcgagcagcg cgctttctcc agatgagccg agcagccaca catccggagc cgttgaaata 3490321 tgcggcgcag cggtcagatt cggaaaacgg tgtttgtcat ccgccaaatc atgcaaatac 3490381 atggtcagct ccttaatttg ctgcggatac tgatcagcat tgcgcttacc accgtcattc 3490441 agcgcccatg atgcaatcgg cattcccccc ggtgctctgc caagccccag gtcaattctt 3490501 cctggtgtca gcccctccag aacacgaaag ttttcagcta ctttataagc actgtaatgc 3490561 ggcagcatga ctcctcctga tccaacacga attcgctttg ttttcgctgc tatatgactg 3490621 attagcacct caggactgga ccctgccagc cgttttgaaa agtgatgctc agaaacccaa 3490681 aatctcttat atccaaggtc ctcagcagct tgggcaagcg caacggtttg ctgtaaggcc 3490741 gtttctgcat tgctgccctc tgatactgga gattgatcta atatacttaa tgaaaccatc 3490801 cctaccacct catcctcatc gtatcactga tcccctattt tttctccaaa gccgctcaca 3490861 ctgcttatca gtgtccccta tcattcgcca tttatttgtg aaagcatgtc cctatttgtc 3490921 ggaatatgtt acacgtgaaa cataaaaacc cctccagacg gagaggtttg ctttagtttt 3490981 tattaaagcc cttttctttc acgtagtcat ttaaatacgt acgcggcttt tgcttcataa 3491041 agttcagtat ttgatcggac cacgtttctt cccgcttccc gtttgttctt tctctatagt 3491101 aatcagaaat ggttttgtca tacgtattca tagtatgacg gaaatcgtct gtgttcacat 3491161 tatacgtatt ttcatgataa acggcctgct ttggcaatct cggttttttg ccggaaaggt 3491221 tcgcaggatg gcctactgcc agtccgaaaa gcgggagcac atggtcaggc gtttgcagca 3491281 cctctgtcac cttgtccaat tcattccgaa tgccgccgat atagcaaatg ccaagcccca 3491341 tggattcagc ggcaatgctc atattttgcg ctgccagcgc cgcatcaatc aagctaacca 3491401 taaacatttc tgtattctcg agcagctcag aaatatgttc acctttttcc tcagccagtt 3491461 gttgatggcg gtacaaatcc gcacaaaata caaaaaagtg tccgttcttc tcaacgtaag 3491521 gctgattccc agcaagcacg gacagctcac gttttttctc aggatcagaa accccgataa 3491581 tcgaatatgc ctgcacatag ctggatgtag acgcagcctg cgcacttttc actaatgtat 3491641 caatttcttc agctgtcaaa agctgatcag taaaagaccg gattgaccga tgattcaaaa 3491701 tggtttcgat tgtgttattc atcacaaaaa cctccttatc actttttatc atatccgaaa 3491761 aaaagtgatc tcaaaagtga aatgctctgc acaaaaaaag acagcctctg taaaggctgt 3491821 ctgcatatca agaattaaaa agataacttc tgtatttcgt cagctgcaca cttgcattat 3491881 atacaatccc aaatccgatt aacgtggaaa gtgtcgagct tcccccatag ctgacaaaca 3491941 gcagcggaat cccggtaaca ggcataatgc caatgttcat tccgatattc tggaatgtgt 3492001 ggatcacaat taacgccgta tagccaacgc aaaagaaaga agcgaaacgg ttaaacggat 3492061 gtattttgtc tatcagaaca acaagcctgt agattaaaaa gaagaacatg atgacaacaa 3492121 ttgcacagcc tataaagcca aatgactcac ctattataga aaagataaag tcagtcgtac 3492181 tctctggaac ataaaccttc aaattagaaa taccattacc taaaatacca ccagatccta 3492241 ttgccatgat ggcctggtca acttgccagc tgtcatttga atcttcctgt gtctcatttg 3492301 aagcagacac ccaagaagtg acccgcttaa tttgataatc ctgtattcca actgatttag 3492361 caacgtcagg aaagtttatc attactaata aaattaatga aatgagtaag atacctgaac 3492421 cagctatgat cgcaatcaat ttccaattta tccctgacat aaaaaccatt acaagaacga 3492481 taaacataca tattcccgca gtcccagcat cctgcatcag gataagacct acaggaataa 3492541 ctgcgacacc cgcaatcttt aataacaagt ggatatcatc cctaagcgtc cgaactcctt 3492601 taggatttgc ttttccaata actgaagcaa gcatcataat caaaccaacc ttcataaact 3492661 ctgacggctg tattgttatt ctaccgatcc taaaccaact ttttgcccct ttaataacag 3492721 gtgcaataga ctcgggactg attttaagaa taatcaaaga taaaatacca atgataaaaa 3492781 tatataaact taacttttca agctgttcta aatcaaagta caaaagaact gtaatggcta 3492841 cagcccccaa aagataaaac acaatttgct gaatccaatc cgtgttccca tactgcccaa 3492901 actgaccggc agcatatatt gatactacgc ttataataaa aaacacacca aatataaaaa 3492961 tcaaatcccc ctggtaaaag gggctttgct gtttcttata tcgactcatt ctatcccgcc 3493021 ttacattttc atcggaaaat cactaatgtt tattatacat gaaccacgtt caagatgaca 3493081 cgtgaagctc gcttcctttt atgttttttc agcatttgcg gcgctttttc agctacacga 3493141 aatatgacgt atcataaacc gaaatgtttc gattgacaca aaacttttca aatgaaaaaa 3493201 acgccatacc aatagaattt gttaaaaaac gaatgcgata atgtgttatg ttcccaaata 3493261 atgtgatacc tcatatagaa atagctaaaa attcagagcc ccatgcccat acattctcct 3493321 agcacattaa acgaaaaaat aagacgatag atccagtcca tttctgcaaa aacacgtatc 3493381 aatttctgga aaacatggta taataattgt aacagaatgt tcaaaaaaca atcacaaaac 3493441 agacacaact cagttcctct atttcatttt tgtaaacgtt atcacaaaat gaaaggagac 3493501 gggtatgatg gacatgtttt ttgcttactt attggttgcc agcgcaacgc ctctctttat 3493561 ttggcttgat aacaaaaaag tcgcactctc agctattccg ccaatcattt taatgtgggt 3493621 attcttcttc ttttacgcaa cagaaagcct ttctccactt ggacacactc tcatgattat 3493681 cttgtttgcc gttaacgtca ttgtcgctca tatcgccgca tttatcattt acggccttcc 3493741 gtatcttcgc agaaagcgaa gcagctgaag acagcaaaaa accctcttcc actgaagagg 3493801 gttttttgta ttattcgtta tggcctgaat gctctgagtg ttcagcgcct ccaggaggat 3493861 ttccgtccat atggtcacca tggtgatagt gagccgcgaa aatccagatg gatccaagta 3493921 cgataacgat cgcgccaaag aatccgaaca gcgtgtttcc gacttggatc gtgccgtttt 3493981 cgctctctgt catatgcatg aacatgagaa gctgcagcgc cgcctgaatg aaggcgaagc 3494041 cgaagataat ccaaagtttt gctgatgagc tcaggtcagt atacactgca acccatagag 3494101 ccagcagggt caaaacgata gacaggataa aacctacaat gtgtttccat ggaaagtgac 3494161 tgtgttcagc agatttgttt gccattttac agacccccca atcccatgag atagacacct 3494221 gtaaagatga aaatccatac aacatctaag aagtgccagt acaagcttga gataaagatt 3494281 ttagatgaag tttgcggagt taagccgcgt ttcttcaact gaatcagaat tcctgtgatc 3494341 cagaaaatcc cgattgttac gtgagttccg tgagttccaa gtaaaacaaa gaatccagac 3494401 cagaacgcac ttgtactgag agccgctcct tcatgtacat agtgaacaaa ctcgttgatc 3494461 tcgcatccga cgaagccggc accgagaaga agagtgataa ttgtccaaat gactacgcct 3494521 tttaaacttc cgcggcgcat ttcatgaaca gcgatcccgc aggtaaagct gctgatcagc 3494581 agcaagaacg tcataatcat taccagattg acttcaaata gttcgtctgg caagacacct 3494641 ccagctgttc tgtttttaag aacgaagaag gttgcaaata gtgttgagaa caacacaatt 3494701 tctgccccta aaaagatcca aaacccgaga atattaagtc tgccggtttc agattgatat 3494761 tccataggcg cgttagaatt gccgtgttct gcatgttcca taactcacgc ctccttattc 3494821 ggaaatcttt ctttccgtct cttttatttc atcaacacta atgtagtagc cgttgtcgta 3494881 ttcgaatgaa cgcagaacca tgcagagcag gactccgatc aatccgacta cgcccatcca 3494941 gtaccattca aagacaagtc caaagcctgc gagaccgaag gcaacagaca taaagaacgg 3495001 tctgcctgag ttgcttggca tatggatttt cttgaatttg ctttcagggt ataattcagt 3495061 tttttcttct ttcatatgca ggaatgcatc ttgagatttg acttcaggaa gcaccgcaaa 3495121 gttgtaatgc ggcggaatcg cagaagaagt cgcccaatca agcgtacgtc ccacacccca 3495181 tgaatctccg ctgatttcac gagtagagta acggaagctg tagtagatgt tatagcaaag 3495241 gattaagaat cctacaccca tcatgaaagc tccgactgtt gagataaagt tcaatgttgt 3495301 ccagccgtca ttcggtccgt atgtgtaaat acggcgcggc atgccttgaa gccccaagaa 3495361 atattgcggg aagaaacaaa tattgaaccc gatcataaag atccagaaga accattttcc 3495421 gattctttcg ttcagcttgt ggccgaacat ttttggatac cagaaaataa atccggcgaa 3495481 acaagcaaat acagtacccg caatcagcac atagtggaag tgagatacaa ggaagtacgt 3495541 attatggtat tgataatccg ctgctgccat cgcaagcata acccctgtaa ccccgccgat 3495601 aacgaagtta ggaatgaacg caagcgccca cagcataggt gttgtaaagc tgattcggcc 3495661 tttatacatt gtaaagagcc agttaaagat tttaaccccg gttgggattg agattgccat 3495721 tgtcgtaatt gagaagaatg agttaacgga cgcactgttc cccattgtga agaagtggtg 3495781 agtccaaact aagaaactca atacagagat ggcgataata gaaccaacca tcgctttgta 3495841 accaaacaat tgttttcttg caaagcttga gatgatttct gagaaaatac caaacgccgg 3495901 aagaataacg atatatactt caggatgtcc ccaaatccag aacaagttag cccaaagcat 3495961 cggcataccg cctgcttcca atgtgaaaaa gtgagcgccg aacaaacgat caaatgataa 3496021 aagtgctaat gctactgtaa gtacagggaa cgcaaacacg ataataacca ttgtgatcag 3496081 tgttgtccat gtgaacatcg gcatacgcat taatgtcatg ccttttgttc tcatttttaa 3496141 gattgttacc ataaagttga tccctgtcat cagggtaccg ataccggcaa tctgaagtcc 3496201 gaggaggtag tagttctcac ccggcccagg gctcatgtcg ttacttgcaa gcggcatata 3496261 actcgtccag cctgcgttcg gagaacctcc gataacgaaa gaaatattga aaagcatcgc 3496321 ccctacaaag aacgtccaga agctcaggtt gttcaagtaa gggaacgcaa cgtcgcgggc 3496381 accgatttga agaggcacaa caacgttgat aagaccgatt aagaacggca tcgccatgaa 3496441 gatgatcatg attgtaccgt gagttgtaaa aatttcatta tagtggtttg agtctaaaaa 3496501 actgttattc ggaagcgcta gctgggcacg catcatcaga ccgtcgacac cgccacggaa 3496561 taacataatt acagcagata taatatacat gattccgagt tttttatggt caacagtagt 3496621 tatccattca gaccacagcc atttccactt tttgaagtaa gtcagaacaa aaataatggc 3496681 aatggttgaa agcgcaatgg aaacttgtgc gcccagaatt aatgggtcac cagttacgaa 3496741 aaattcgtcc catttgaatt tcatgcaggc ttcctccttt cctgatcaat atcattcttc 3496801 tgtatcatca gacttcttaa attcgttttt ctttacgttt tcaaacggat ctgttttaga 3496861 atgcggtgaa acggcttgat agccaaggcg tttgcgcgcc tccatcgcgt actcagcgtc 3496921 ttgtccgtga tcaacgtatt tcaagtgagt agaagagaac gttaattcgt ccacattttc 3496981 aggaagcatc aattcatcat acttctcttt tgtcagctta ggagcctcgt tctgagtctt 3497041 tttcacccag ctgttaaagt ctttttctgt gactgcattc acatcaaact cttggtctgc 3497101 aaaatgttca cctgtgaagt tcgcgttgcg gccttcgtaa gtacccactt tgtcagcctg 3497161 taagtattga tccatcagca ttcctgccat cgcatatttt tgccctccaa gctgaggaat 3497221 ccatagcgaa gccattgaat ctgcagatga gattttgaac aagatcgggc ggtcgacagg 3497281 aatgtttaag tagttgaccg tttcaatatc ctgttcaggg tagctaaata cccatttcca 3497341 gtctaccgaa gtagcataaa caacaagagg ctctttgtct tttgttgctt caggagcttt 3497401 ttctaacgaa tatatcgtct gtactgttgg cacagaaagt gcaatgacga ttaaaattgg 3497461 gatcactgtc cagactactt ctaaaaacgt gttaccgtga atttctgggt tataagatcc 3497521 attatctttg cctttacggt cgcggtattt tactaaaata atggtaaata gaacaaagac 3497581 gaccccgacg ataaacagca taaatccgat agataacagg attaaatcac tttgctgttc 3497641 agctacaggt cctttcggat ctagtactga agcattgctg catcccccaa ggacgaaaac 3497701 cacagttaac agcgctaata caagcaacgg ttttaatgct ctgaacaaga agatcaccat 3497761 ccttcctatt gatgtaataa atctgaagtg catacttcct caaaatcttt tctctacttt 3497821 gttatgctat caaaaacttc acttattagc tttatttttt tataaacttc atcccatttt 3497881 cgcttaaatg tcataaaatc gacaaaaatt gctccaactt tattcacatc tatcgcttaa 3497941 gatgaaaagt ttctagttat ttccgcatat aaagtaaaga aagatgatga agaactaatt 3498001 ctgacaaatt aaggtttacc acaataaaaa acttaggtca atcaaaaatt tcattttgtt 3498061 aaactttcta gataggaatt attttttcct cgtctagcat cttttcacac ggttaccatt 3498121 ttaacgcatc aaatattgaa agaaaaggcg caatgaagag ccaatatgct ctgaattgtc 3498181 cgtatttttt tatgagagca tccagttgtt tatcttatac aaaaaagagg aatgatataa 3498241 gcaaataaat aaaaaatagg atgtgttgca tgatgagttt tcttatttca cttatcgtcg 3498301 ctattattat cggatggctt ggaagcctgt ttgtaaaagg agatatgccc ggaggaatta 3498361 tcgggtctat gatcgcaggt cttataggcg cctggatcgg acacgggctg cttggaacat 3498421 gggggccgca cctagccgga tttgccatta ttccagcggt aatcggcgca gccattgttg 3498481 tctttctagt aagcctgtta accagaaaaa gaggataaaa gcagcagcac ccgaagcgtc 3498541 agcgctttgg gtgtttgttt tgccataaaa atcgaaaaag cctcaaccct agcggttgag 3498601 gcttttgact ggtttggcgc ccaactgatc gatgaacctt ctgaaggcct gttttccctc 3498661 tgctgtctgc ttaaatacac cggcgtgttc aaggatgcgc gcgaatacat gtcccagctc 3498721 ttcttttatg actagatcta cgttctcttt tgttatggtt cttttttcca tcgtccgaag 3498781 agcccactca ctatgctttg cagtgagcgg attttgttct aaggctgttt tcggatcagc 3498841 agaacatagc gccgctgccg tttctttcat ttcctcctgt aagcggccag gcaatatcgc 3498901 caatcccatg acctcaatca ggccgatatt ttctttttta atatggtgga cttcttgatg 3498961 aggatgaaat attcctaatg gatgctcctc atccgtccgg ttgttcctca gtacgatatc 3499021 gagttcgtac aagtctcccc tgcgccgcgc aatcggtgtg accgtattat ggggcgtatc 3499081 gcctgtatag gcggcaatgc cggctttttc atcggaatac gtctgccacg tgcggaagat 3499141 atggtcagca gcttcggcga catgacccgg ttcgtctcct tggagcctga gcacagacat 3499201 cggccacttc actaagccca gcgacacgcc gggataatca tttaattcat aaacgtcttc 3499261 cgcttctgca cgtgccattg gaaaatcatg cgcgccgcct tggaaatgat catggcttag 3499321 gatgctgccg ccgacaatcg gcagatccgc gtttgaaccg ataaaataat gcggatattg 3499381 gccaagaaat gacagcagcc tttcaaatgt ttttttgctg atctccatcg gttcatgttc 3499441 accttttaag acaatgcagt gctccggata atagacatat ggcgagaatt gcaggaacca 3499501 ttgttcgtcc tcaaggatga ccggaatgat tctgtgattt tgccgggctg gatgattcac 3499561 gcttccctcg aagccgacat tttctttaca cagcaaacac atcggataat ttgtctgttc 3499621 ctgctctttt gcagccgcaa tcgctttcgg gtccttttca ggctttgata ggttaatggt 3499681 catttccagc tcgccatatt cggtcggcac cgtccaatga acatttttgg cgattctgtc 3499741 agtccgtata taatagacat cctctgaata ttgatagaat tcctttgtcg cctgttttgg 3499801 gccgtataat gcttttgtct cttcaaattt gcgaatgacc tcggacgggg caggcacaaa 3499861 acagcccatc agctttgcgc tgagcaggtc acggtacgta tctgtatccg cttccattcg 3499921 gccggtttcg gcagcccatt tatagatggg agctagcaag tccggcaggc tttgtgactg 3499981 cttgatgctg gtgctggagt tcggctcggg atgtgtgatg cccagcgctt cataaagacg 3500041 gtttctcgta tattcccgat cccagatcga aatcaatttt cgttccaggc catactcaag 3500101 cagctgttcc agatgttcaa taatactcat atgtcactcc ccctttagtt ctctcgctcc 3500161 ctctccgata tccgcgacat aaaagtccgc tcggagccct gttttttctt gatatctgtc 3500221 tccaaccttc tgaataaaat catcaacgaa ctcatctttt acaatgctga tggtgcagcc 3500281 gccaaagcct gctcccgtca ttcttgatcc aattacacct tcgtgatccc atgccgcaaa 3500341 cacaagctca tcaagttcag ggcatgttac ttcatagtca tccttcaatg aaaggtggga 3500401 ttccttcatt aactgcccga tttcatctat attgttctct ttgaacatat gggccgtctt 3500461 aatagcacga tgattttcgt atacagcgtg ctttgcccgg cgtctgttcg tttcattttg 3500521 gatcaggctg gaatgcgcat cgaaatcaga aggcttgatg tcgcccagtg cggcaatatc 3500581 gaggcctttt ttcagatcaa gcaatgcatc attgcattct tggcgtctcg tattatagct 3500641 ggagtcagcc aatgtccttt ttttgttcgt gttcgcgatg accagcgcga ggcctgagac 3500701 attgagtttg ctatattcat agtcaagcgt gtcacagttc agcagcatcg catgatgttt 3500761 tttccccatt ccaattgcaa attggtccat aattccgcaa ttgacgccga taaaatggtt 3500821 ttccgcatgc tgcgccattt tcacaagctc aagcgcatct acttcaggat gaaaataact 3500881 ttggagcacg acccccatca gcagttcaat agaagcggaa gacgacagtc ccgccccgtt 3500941 tggaatattc cctgaaaata caatgtcaaa gccatgggga actgcatatc ccctctgttg 3501001 aaattcataa atcacgcctt ttgggtagtt cgcccagtcg tcttcttttt gatagcgaat 3501061 gtcgtcaagg ctgcattcct tgatgcctgc gtttctaaag ttatctgaat acatccggac 3501121 aagcccgtcg tttctttctg caacagcagc atatgtaccc attgtcagcg cgcacggaaa 3501181 gacatgcccg ccgttatagt ctgtatgttc tccaatcaga ttcactcttc caggtgcgaa 3501241 aaaaaaccgt aacccctctt tttctccgaa tacacttgca aatatcccct ttagctcttc 3501301 ccgcatgtgc aatcaccttt ctggttttta ttttttattc cccttatttc ttcatagaaa 3501361 acggcagatc atatgctgca gtcctctcat accccttctt cttttgtttt tttaaagacg 3501421 agccatttgc tcgcaacata gttgacgaca acaatgaccg cgttgtcgag tattttggcc 3501481 aaggtttcat ttgtattgaa ctggccgaca agaatgatca tcatgcctaa atctatgccg 3501541 agagacagga cccgaacgct gaaaaaagca gtgagctctt tcagcaggct ctgcagatca 3501601 tgtgtttttt gctgaaacac atataattta tttgttatgt aagcaaacag cacggacaaa 3501661 atccaagcgg caacagtggc ggctttgtaa tccacattca tgatctctac caatatataa 3501721 aagctggcga tattcacaat ggttgtgaaa acccccataa tgatatacat aattatttct 3501781 ctatacttca ctgatgttcc tcgctttctg aaaaactttt caaaattctt ggcctctcgt 3501841 gctctctgtc taaagtaaaa aataccgaga gtgcgtctaa aaagctgcgg aaggtggctg 3501901 gctggcccaa tacatatgat tgtttgatga ttccgtcgag gactgcacat attattttag 3501961 ccgtatattc aggatcaata caggcgtcaa tcagctttct ctccttcagc cacttaatat 3502021 ataacacatt ttcttccacc cacaattcgt acagccggac ataggccttg catttcttta 3502081 agactttata tgtcggcatg ttcatggcaa acgaggtgat gtcccacgac ggcttattta 3502141 tgtaatagga ataaagcagt tctgcagcgt gttttgcagc ctcgtccaat gtcagcgatt 3502201 tcactgactc ccgctccatt tgatcaagat accctataat gatctttttt ttcatctgac 3502261 gtttttcgag aaggtacagc agaaaatcgt ccttgctgac aaaatgaaca taaaatgctc 3502321 ctttgctgta cccggcggct ctgctgatat cttctacaga aaccggatca tacgctcggt 3502381 caatcaacaa attcacgcca gcgtctataa aactttcaaa tgttgcttct cttttaattt 3502441 gaaatttgtt ttttttcata tttttctcct ggcggtaatg attaccctta tcttacaccg 3502501 gatcaatctt tagcggtatt tatttcttta aacggttatg ctattcggtt tcccaggggt 3502561 catttttaat aggctaaatg atttattttc atttacatac tatccagtca gtatttaatt 3502621 gtttattatt ataaataagg tccattggtt atattagtca tttttttagg gaataggtag 3502681 gtggtttttc cttcagtttg tgaacaccga gcaactatgt gtgaaatttg ttgtactcgc 3502741 ctccatcatc gcgctggctt gtcttttatt gcccgcatgt tgcaggaaaa cattttatac 3502801 aattggaggt tactatgaaa actcatgtta aaaaagattt ggacaaaggt tggcatatgt 3502861 taattcaaga agctagatcc attggattag gcattcatga tgtgaggcag tttttagaat 3502921 ctgagacagc atcaagaaag aaaaaccaca aaaaaaccgt ccggcaagac tagtccgaac 3502981 aggcggatct atttacctct ggcttttcta tcacctgatc tgagttttca ccatatcctc 3503041 tattcaaaag caaatcgctg cgctgagctt gaggacaaac ggtgtgtcag ctaactacga 3503101 cagacagccg gtgatgcgat cacctcttgg cacatgcatt gtcataaaga ggtgatgcga 3503161 acatgataac cgtgctctgg taaacagcag ctttgctgag aacaagctgc attcggtgag 3503221 gttttgaaag caaactcgtt tatacacggc cgagcttgaa aaccttcgcc tgtctttaga 3503281 ccactgtgtt cacctcttca cgacttcctt cttttttcat cctccagcta ttgtacaacg 3503341 cataaatcgg actttcagta catacctatt ggtgtacctt tttgcttacg tttagcgaat 3503401 aaaaggagga aagccatgta caaagctgat tataaacaga ttgctgcaac gccgtctttt 3503461 caagcttttt taaagcagaa acgcgctttt attgttcctt ctgcgatttt cttttttgtt 3503521 ttttattttt cactccctgt tttgacatct tatttcacct ttttgaatgc accggccatt 3503581 ggagctgttt catgggcttg gctgttcgcc atcgcccaat tcgctatgac ctggatactg 3503641 agtactgtgt attcccggag agccgcccat ttcgataagt atgtaagcgc tttaaaagag 3503701 gatctgaagg gtgaacagac atgaatatga ctgctttttt attatttttg gcgattgttg 3503761 gcctgacgct tattatcacg tattttgccg cgaagcggac gaaaacgacg agtgagtttt 3503821 atacggcggg cggcgggctc accggcgttc agaatggact ggcaattgcc ggtgactaca 3503881 tgtctgccgc ctcgtttctc gggattgccg gaatgattgc gttatatgga tttgatggct 3503941 tcttttacag catcggtttt ctggtggctt atctcgttgt cttgtacatc gtggcggagc 3504001 cgcttcggaa tcttggaaag tacacgatgg cagacatgat tgccgctcgc tttaaagaaa 3504061 agaaaatccg cggtgtcgcg gctctcaata ccattgccat ctctactttt tatatgatcg 3504121 cccagctcgt gggggcgggc gcgctgatca aactgcttct agggctggat tataccgcgg 3504181 ctgtcctcat cgtcggagtg ctgatgacca tttatgtcgt gtttggcggc atgatcgcga 3504241 caagctgggt tcaaattatt aaagctgttt tgctgatggc cggcacactc gtgatttcga 3504301 ttatcgtgtt ttcgaaattc ggctttagcc ttaataccat gtttgaacag atgaaaacgg 3504361 ctactccgct tggcgctgat tttttgaacc ccggaaataa atacaaggtg ccgcttgaga 3504421 ccttgtcgtt aaacttggca ctcgtgctgg gaaccgccgg gcttccgcat atattgatcc 3504481 ggttttatac cgttaaggat gccaagacgg cccgtacatc cgttgtgtca gcgacatgga 3504541 ttatcggtgt gttttacatt atgacggtat ttctcggctt tggtgccgcg gcatttgtcg 3504601 gttttgacgc gattacggcg gctgatcaag cgggaaatat ggcggctccg cttttagcaa 3504661 aagcgctcgg aggagacttt ctgttcgcgt ttgtatcagc catcgccttt gccaccattt 3504721 tggctgtcgt gacagggttg gtgctgtctg ccgcctcagc atttgcccat gatatttaca 3504781 gccagatcat cagaaaggga gaagcaactg aaaaagaaca aatgaaagcg gccagatggg 3504841 cttctgtcgc cgtgtcagtg ctctcgattc tccttgcgat ttttgcacaa tccttaaatg 3504901 tggcgttcct tgttgcactc gcgtttgcgg tagccgccag cgcaaacctt ccgctgattg 3504961 tgtttacagt cttctggaaa cgattcaatg cctcaggcgc tttatggggc agcctgacag 3505021 gcctgatcag cgcgcttgtg ctggtatcga tgagccctag tgtgtgggac ccggccggag 3505081 gtgctatttt taccggtgat ccgctcattc cgctatctaa tccaggaatt atttccatcc 3505141 cgctcggctt tctcggcgcg tggctcggaa cggtgctgtc gtctgataaa acaattgatg 3505201 aagatacgtt tgcagaaatt caggtgaagg cgcatactgg cgtccatatg gaacaggaat 3505261 aaaaaaagct ctctttatcg agagcttttt ccttactttt tcttctgctc gtcagaaatc 3505321 gctttttcaa atacatcctt gccggcagca cccggaatta cagtgtcacc gataataaag 3505381 gttggaacgg ctgtgatgtc agcctcttca taggcgtgct tcaaggcttg gcgctgcacg 3505441 tcctgatatg ttcttgtttc cagtgctgat ttgaatgatg caccgtctaa tcccacttcc 3505501 tcggcgagct tcgtcaagat gtcaatatcg ccgatatttt ggtcctcctg gaaaaatgcc 3505561 tgaaagacac gggtgttgta ttcatgtcct ttattgtatt ccttcgcaaa atggaagcct 3505621 tcaaacgcga ggtctgtata cggatggggc gagacgtttg gaaaattgat ctcgactcct 3505681 aatttctccg ccattggctg aattgatgtc tgccacatgt actgtttaga aggatcattg 3505741 accggatcaa gctgaggaga tgggcttggg cgcagttcaa acggcatcca ctcgacttca 3505801 acatcctttc cttttatcgc ttcttcaaaa gcggcttttc caacaaaaca aaatgggcag 3505861 acgtaatctg aataaacttt aatgtgtact gtcatgataa tctcctttca tactaaattg 3505921 attttaaact gtaacaatta aagttacaac tgttttttaa taaagaagcc gatttaggct 3505981 tctttcagat tgatgacaaa atcctaaaaa gttttaggat tttgtcatcc tttcagcgtg 3506041 attgaaaacc cttgaagtct aggaaagccg agcattggag cggagcgaat gctctaattc 3506101 gtgagcacca acgcacaggc ttgacaacga atgcgagggt ttgtcgacac gctgaaagaa 3506161 gcctgtaaag gcttctttta tgattccagc aaacgctggg caatatattc tccttttttg 3506221 cagccgcctg ggcatgcgta taaagcagaa ccgattgttt gtgtatattc gtttaacgca 3506281 tcctttgctg aaagagcctt cagcatcggg ataaactgat tgtcgggatt tttttgaaaa 3506341 ctgataaaca ggagacctgc atccatatag ccggttttcg gatcaagtcc ttctgtgtaa 3506401 gagaaagctc ttcgcaaaat ttgtttccca gtagatttcg ctagactgac gtgtgaatta 3506461 gacggaattt gattcagctt cacgggatct gtttcctttt tctgcccaaa aggcgccccc 3506521 gagctttttc tgcggccgaa ggtatcctct tggtccttga gggaagagcg gtcccatacc 3506581 tcaaggaaca ttttgatttt ccgaaaagcc atataggtgc cgcccgtcat ccagtcaggc 3506641 tcaccagact gaatccacac gatcgagttc atcaacgtgt catccttcgt gctctggttg 3506701 cctgttccat ctttaaaccc gaagaggttg cgcggtgttt caccattttt tccaccgctt 3506761 aaaaagcctt tgttcacaaa acggacctca caagtgccga ccgcttgatt tagcaggtta 3506821 cgcagcgcgt gaaacgccac ttgctcgtcg tctgcacaca cttgaatgca gatgtccccg 3506881 cctccctgct tttcatccag gttgtcattg ggcatcgctg gaagagcggc taggtgcttc 3506941 ggttttttgc ttttcagtcc gaagcggtcc tttccgtctt tttcaaaaaa gccaggcccg 3507001 aatccgaatg tgaccgttaa gttggaaggg gataaatcag cagactcacc tgtatcctgc 3507061 ggcggcagat actgatttct ctgctccgct gacattttct tgccagacgt cagcatctgt 3507121 gtgagacttg tccagtttct aaataacgta atgatgtcgc ttttgtcttt tgctgttaca 3507181 tccagtgcag caaaatagac atacgtctga tgggcagttg tgattccggc ctgatgcttt 3507241 ccgtaaaacg gaacaatctg ctcctcctct ttttcatcct ttttcgatgg cttagccgca 3507301 gtctgaacaa gcggagcgag accgccgaga ccgctggcac cgatcgcaac ggctgccccc 3507361 gccatcgctc cccattttaa aatgtcccgt ctgtgaattt gttctggctt tttctgttca 3507421 tcgctcatga tgttacaaaa ctccttttat agcacattcg caatcttcga catggtttca 3507481 gaaagagtcg tcagcttagt gctcagctct ctgatttgct tttcacttaa tttatcataa 3507541 gacgtatagg actgatcatt tgttttgtat tttgccatta aaacttcaaa ttcgctgaac 3507601 tccgtatcca gtttttccgt caagtcggag tgatctttta caagcgcgct tttcactgtt 3507661 tgataaacgg cttcggagcc ttccacattt gccataaggt caactaaatc aattcgtgag 3507721 tagcgctctt cttctcccgt gattttcgaa attccggctt cgttcagaag ctccatcgcg 3507781 cctgcaacaa tttgttcagg tgttaatttc agtgattgaa ttgaaccgtc aagctctttt 3507841 acatccttga gaagctggtc agctgttgcc ttttccccgg aaatatcttg atccttccaa 3507901 atggccttct caagcttatg gaagcctgtc catttgtctc cttcttcaac atcgttttct 3507961 cgtgcgtcaa ttttcggatc aagatctccg aggctttcag cgatcggttc gattcgctcg 3508021 taataaacac gcgctttcgc atataacgtt ttggactttt cgatatcgcc ggatttcaca 3508081 gcacccgtaa atgcttcagt cgctttgaca agctggtcac tctgctcttt gacatagcct 3508141 ttatactcat ccgctgcttt tgccagctga tcgctagcct ttttgccgct cttcttcgct 3508201 tctgtcaggt cttctaagga tgctttcaat gactcggatt ctgtcttgat ttttcctgca 3508261 tccggtttgt ctttttgcgc ttctgtgtag attggctgaa gatgcttttc gatttctgta 3508321 tattcgaatg gatagtcgct gcgaatatcg ttttcaaagg aaagccagta gctgtttaac 3508381 tctttcccct tcttttcaat ctctttttgg tctccttttt ccactgagtc attcagctta 3508441 gaaatgatgg tttccatttt atttacggat gcggtgattt ctttagtgac cccgcttttt 3508501 tcagatgaag ctttttcttt ggttgaagat gtgtcattgg ctccgcagcc tgcgcacagc 3508561 gcaaggatgc atccggctga tacagcgatt tttgtgaaat tcattttgtc agttcctttc 3508621 cgtttgtaaa atgttttgcc gcttctgaaa caagcgcaat cagtaaaaag agtaaaatca 3508681 acatttgcgg aatcgtgctg tacacagacg gataaattcc tagcaccgat acagacggca 3508741 gccagctttc tgcatcagac ggaagaatgc ccgccagttg aaggctgtga acgccggttc 3508801 cgagaaattt cacgcacata tacaggacaa ccgccattga tagaagaaaa aacggcttca 3508861 atggaatgcg cattccgagc ttgatcatca gaacaccgac gatgacgaga acgataagcc 3508921 ctgcggcagt tccgccgatc agttcagtga gcgggagctt cccgacaagc ccgatgaaaa 3508981 agatgaccgt ttcgagacct tctcttacaa ctgccagaaa tgcaatgagc gcaaaggaaa 3509041 gcaggcttcg tttttttagt gcctgtgact tctggatatt gattttttct ctccatttat 3509101 ccattgaggc gtttctgtgc agccacaccc cgacatacaa aagcatgaca gcggacagta 3509161 cgccggtaac gccgccaagc aagaaattgt tttctccgaa tacactggag gagaacagaa 3509221 ccgtgacacc gatgccggct gctaaggaaa cagccatgcc ggcggacgcc ccgccccaga 3509281 tccatgtcga ggaacgcgta acccgcgctt tttttgtcat ggttaatagc gctccgatga 3509341 caaggagggc ctccattcct tcacgaaccg ggatcagcgc cgcatcccac cagctgtagc 3509401 tgcttgaagc gatcggctcg agcaattgaa tcatttcgtc aatttgcttt gatacctttt 3509461 caggatggct gccgatctcc gccttcatca gcgccagatt ttcctccgat gtcgtatagg 3509521 cttctttcga ttgggacacg acatctccct caacagcgag ccaggatgta actaaattgt 3509581 cgattgcgga tgacgcttca tccaattgtt ttttttctat gaactgtttt gtgtctttca 3509641 agctttgtat ataggctgtt aaggacgccc ttgattgacc tgaggatgtc tttttcagca 3509701 cgacagcctg ctgataggtt tctaaatgag acgcaagctc ttcaagctgt gttttgagct 3509761 tacgtgcgtc ttgattgata aaagaaagag aaatcatcgc gatattcgcg tccatttcac 3509821 tgtgagaaga aaggttttct ttcttaatag aaggttcttc ttttttccac ttcgccttga 3509881 aggtgtcaaa cgtttgttgt gccgaatcca tatccccgtc ttttacggat ttgatcattt 3509941 gcttgtttaa ttgaattaat gcggcgatcg gatcatcttc cgcatgtgcc gcagaaccga 3510001 aaaccatcaa caagctgaat agaataagtg ccagcccccg agccatcatg ttcctcctat 3510061 aattgaaaat gattatcatt gtataacata atcatagcca gttcctgtcc tttgtcaatt 3510121 aaaatttgaa ggtctgaaaa ccttgatgga cagcaaaaaa gctgtccttt tacagaacag 3510181 ccctttgaag gaaaatgaac gattatcttc ctgttttata cgtttgaatt tcctcacgaa 3510241 acttgcgtgc agcactctca ggatcctccg cctgactgat ggcgctgatc atactgacgc 3510301 catcggcccc cgcttggata acaggtgcgg cattatctat tgtgattccg ccgatgccga 3510361 caattggaat gctgatgcct tggcggcgca ctgcttcgat aagagataca ccctgtaccg 3510421 ctctcgtatc ttttttcgtt tcagtcggat agatcggccc aagcccgaca taatccgctc 3510481 cgtcttcttc ggcttgcttc acctcagaca tcgtatgggc agaaacgccg agaatcatat 3510541 cacctatggc agctcttacc tctttcgcat ttgcgtcttc ctggccgatg tggataccat 3510601 cagctttcag attcagagcc aattccacat catcattgac aatgaacgga acaccagctt 3510661 cacggcaagc tgcctgcgct ttttcagcaa atttaatccg agcctctcct gtcagcgcat 3510721 ccccgccttt ttcacggaac tggtacaggg tggcaccgcc ttttaacgct ttttgtacaa 3510781 ctgtaacagg atcggctttc gtattgtttg accccataat gaagtataca gataataact 3510841 ctttcatcat ttcccgagaa atacgagtca tgagacagtc accctttcta tagtcgccca 3510901 ttcttggacg tcttgttcag taacagttga aagcttgttc agcaattcaa tctgaaagct 3510961 tccagggcct ttgtcagccg tctgctgtgc ggcaagctga gcggcgaccc catacgaaga 3511021 aatggccgca atagcagcaa acaatggatt ttcttccaca gcgcaaaacg caccgacgac 3511081 ggaagtcagc aggcaaccgg cgcctgtcac ttttgtcagc agcttgtggc cgttatgaag 3511141 ggtgtataca tgtgacgtgt cggctatgac atcaacttca ccagttatcg caatgaccgt 3511201 gtttagcttt tgtgccgcct gctgagccag ccggatgatg tcgcctccac cttcacccgc 3511261 atcaacacct ttgatcagcc aatcggtcac gccgacggta tgggcaattt ccgccgcatt 3511321 tcctctgatt gcagcaaggc gcacctcacg aatgatgtca cgtgccgatt cagtgcggaa 3511381 cggtgttgct ccggcaccga caggatcaag aatgacggga acgccatgtt cattagctga 3511441 ttttcccgcg atgatcatcg cttcgactga ctccttgctc agtgttccga tatttaaaac 3511501 gagtgcaccc gcaattttcg ccatatcggc gacctcttct tttgcgtacg ccataacggg 3511561 cgatgcgccg agcgcgagca ggccgtttgc tgtgaaattc gttacgacat tgttggttat 3511621 gctatgcacc agtgggctat gccggcggac agccgtaaga cattttgctg ctgattgtgc 3511681 atccatattt gcatcatcct ttactatctt ttttcgggtc ccataaatac gatttcgtat 3511741 gttcgagcca agctctggcg gcaaacgaca agtacctgtc ctttctccaa ataatggcga 3511801 ggtgccaagg gatgaccgga tcgacaagcg gaatgacttt cactttttcc gggtcaaggc 3511861 cgcggcagat ccgttccggc aaaagcccga tcccaaggtt ggcggatacc atctcactaa 3511921 taaaatccca ttgtgatgtt tcataaatga tatggggccg gaacccagcc ttgatacatt 3511981 ccgtcataat tcggttgtgc aggacaaaat cctctctgaa gaaaataaaa ggctcgtcct 3512041 tcaactcacg cagctgacat tctttctcat cagccagccg gtgggaaggg tgaacgacaa 3512101 gcattaaggt ttcttttacg attgtaaacg aatgaaagat atcttcgttt gcgggaagga 3512161 ccacaacgcc gatatcaaga gagccgtccc cgacaccttc ttggactttt atagaaccgt 3512221 cttcgactag ctgaaaggtg acattcggat agttttcacg gaaatcgccg agcactctgg 3512281 ggaaaaaccc cgatccgatc atcggcggca gtccaatccg tacgtgccct ttcttgactt 3512341 ccataatatc atttaattct gacgtcaggt tttgaaatga tttaatgatt tcctgcgcct 3512401 gcacatacat gctatgaccg gcatcagtca gttccacctg cctgccgttt cggtaaaaca 3512461 gttcaattcc gagctcttct tctaaatttt tgatcatttt tgatatcgtc ggctgagaaa 3512521 cataaaggga ttgggaagcc ttcgtaaaac tttttaaacg ggcgacttcc aagaaatatg 3512581 ttaaatggcg gatatccatg cgcttcaccc tttctataga caaaaggaat acttcttatt 3512641 cttaatatat attttaccta tagagagacc ttatgtacaa taagtatata agggaggcat 3512701 caatatgaaa aaactgttgc taaccgttat tcaaatcgct ctgttattta tatttgctcg 3512761 gctgattaat tgggtgacag cccttcttca tataaatatt cccggcagta taatagggat 3512821 tgtgattctt ttcacattat tgcactttaa cattatcaag cttgaatgga tcgagcttgg 3512881 tgcagcgtgg cttctcgggg agctgctttt attttttatc ccgtctgccg tcggagtgat 3512941 tgaatacgga gacattatgt cgaaatttgg tgtcagcatt ctgcttgttg tcatcatcag 3513001 cacgtttgtc gtgatggtgt ctacaggaac gcttacacaa ctcatcgcaa agagaaagga 3513061 gaaaaagcat acgtgttcat cggaattgta agtttgtttt taacggtttt ggtgtattta 3513121 ggagcaaaaa aggtatatca acgctttccg cgtgtttata cgtcgccgct attggtgacg 3513181 cccgctgtat tagtcggtct gctgctgctg gtgaatgtcc cgtacgagtc ctataatctc 3513241 ggcggcggat tgctgaccga tatgctacag ccggccaccg tggcattcgc gatcccgtta 3513301 tataaatatt tccctgtttt aaagaaatac gcagtggaaa ttattttgaa tgtggccgtc 3513361 ggttcatgca tcgcgattat ttctaccgct cttattgcga aatggcttca cctcggcacc 3513421 ggcttaattg acagcctcgt cccaagatca gtgacaacgc cgatcgcgat gaacgtatct 3513481 gaaatgatcg gcggtatgcc tgccgtcaca gccgtgtttg tgattttaac cgctttgctc 3513541 ggcacagtga tcggcccgat ggtcatccgt tatttccgca ttgataacga aattgcgcgg 3513601 ggcgtgctgc ttggcacaag cgcgcacgga gcgggaacgt caaaggcatt tgagctcagc 3513661 tctgtgtccg gcacgatttc cagcgtgtcg atgatcttag ctgcgattat gacgctttgc 3513721 gcggcgccgt ttttgctttc atttatgtaa aaaactgtcc tctcgagggc agtttttttt 3513781 atgtgcttcc ccttattgaa aagctggcga attccaatat aatgtatttg tggataccaa 3513841 aggaggcacc ctgatgcaca acttgcaggt gaggcggcat tatgccgcgt taaaaggatt 3513901 ttatttgttt gcttttctcg gtacgggcag cataattccc ttactcagta tgtatttaac 3513961 gaaggaacag catttaagcg gatcacaggt cggcttgatc atgtcactgg gcccgattgt 3514021 gatgattttc tttcagccgt tttggggcat gctgagcgac tatacgcaaa aaacgaaagg 3514081 cctgctggcg gtttgcacat caatcacagg catcattgga ttagcctata ttgcatttga 3514141 cagtttccct ctgtttattt tgattgcggc ctgttttgca gcctttcaaa gcacgattat 3514201 tccactttcg gacagcattt cactaaggta cacacaagaa acaaacggca actacggcgg 3514261 aatccgcctg tttggttctc tcggcttcgg tgtcgcggtg tttgccatgg gacaggtgac 3514321 gaaccagctg taccccattc acgtgatctt tatctttggc tgtgcctttc tgtgcattgc 3514381 tgccatattg gcttcacaag tgcccggcca gcagaaaaca acaaaggtca atatccgcaa 3514441 aggattccgg gagcttatca gcaacaaaac tttcctcatc tttatgatca tcacctttac 3514501 gacatttgct ccaaacttag cgaacaatac gtatttcagt ctttttctgg acaaaagcgg 3514561 cgcgtcactt tccgctatcg gcattttatt tttcatcggt gtcatttcag aaattccatt 3514621 tatgagattc gcccaaacat ttatagataa aatggggctg ctcaacgtca ttatgctgtc 3514681 aggcggagtc tcattattca ggtgggcgct ctatttcacg gcgccttcac tatggatcat 3514741 ttatgcgacg gtctttcttc agggagtggc catcggttta tttatcccgg cggcgcttca 3514801 atatgtgaaa aagattaccc caagacacgt tgaagcgacg gcgctgacca tgtacgccgc 3514861 cattggcaac gggttcggca actggttctg cacatttgca ggcgggtaca tttttgacta 3514921 cgtgtcgatc ttcgcagtct acttgctttt tggcattctg agcatagcag gctttggcct 3514981 gacattatat ttaatgaagg ctgaaaaaaa caaacataca cttcatcagc cggctgttac 3515041 ttttaaacca taatgactat aatgaacaaa agaaaggatg tgcgttatga acgggcaaga 3515101 gcgaaacagc atttcgaaag ggttgcaggt tgatattgta ttgaaagcag atcaaaaaac 3515161 aggaaaactg acgagaggga cagtgaagga tattttgacg aaatcaaact ttcatccgca 3515221 tggcattaaa gtccgtcttg aagatggccg catcggccgc gaccagcaga tcgtttctac 3515281 ataaaaaaaa gctgcccctg aacagggcag ctttttcatt attttttctg cagaaggacc 3515341 actttcaggt agttgccttc cggaaatgcc gaaatcgttt tgaaatcctc cggcagcgta 3515401 aattcctcaa tgatcgtgta gcgttcattt gtttctttaa aggcggcatc aataaagcct 3515461 ttgaacttct tcatgccaaa ggcgctgctg tttgtagagg caacaatgac acccttgtca 3515521 gcagtgatgg cgatcgtttc cttcagcagg tttttataat ccttggccgc gctgaaggtg 3515581 cgtttttttg tgcgcgcaaa ggaaggcgga tctagaataa tcagatcaaa gcgcaaatcc 3515641 ttttttgcag catatgaaaa atagttaaaa acgtccatca ctttaatgtc gtgcgcttcg 3515701 taatccagct tgttcacgct gaattgctcg atcgttttgg caagacttcg atttgccacg 3515761 tcgacgcttg ttgttttctc cgctccgcca agcgccgccg ccacggagaa tgcacccgta 3515821 taagaaaacg tatttaaaac ggttttccct tttgcatagc ggtctctgat cgccttgcgc 3515881 acatgtctct gatccaaaaa gatgcccgtc atggcgcctt cattcagatc caccgcgtat 3515941 tgaatgccat tctcttggat gatgatcggg aactcgcccc ttctcccttt cacgaagtca 3516001 tcatcttcaa cgtattgtcc agccgtgtcg aagcgtttct tctcgtaaat cgctttataa 3516061 tcaagatcca tctcatccaa tgcggaaatc agcatgtctt taaaggtgta aattcccttg 3516121 ctgtaccatt gaatcagcag gtagccgtca taatagtcga tggtgacgcc gccgacaccg 3516181 tcaccctcac cgttgaacag gcggaaagct gttgtatctt gagcctcaaa tagtttggcg 3516241 cgcgcttggg ccgcttttgt taatttgctg agaaaaaatg cttggtcaat ctgttcatgt 3516301 ttattgcggg taagcgtcca gccaacccct ttgttttgca ggccgtaata gccccgcgcg 3516361 agaaactcgc cgccgctctc agacacgata tcaacgaggt ctccttcttt catgtgcccc 3516421 gcactccctg cgagagcttc tttttcaata aggggatagc ctttttttat tttggcagcg 3516481 tgtgcttttt ttagggtgag tagcttcata tatgtcgtcc tctttccgtt tgctttctct 3516541 tatggtacca caaaacgcca agatgtctgc attgacagaa aggaaaggtt tttctacgat 3516601 agacaaaaag agttacgagg aggagcagca tggcaaaacg aattgaccat acaggcatca 3516661 tggtaagaga tattaacgcg tccatcacat tttatgaaga ggtactaggc atgaaattga 3516721 aggatcgcat cactcacacg aacggtgtaa tcgagcttgc ttttcttggc tttgaagacg 3516781 gcccggaaac agaaattgaa ctgattcaag gctacagcag cgagcttccc gctgaaggaa 3516841 aagtgcacca cattgccctg ctgacggatg acatcgcggc tgaatataca aaagcggaaa 3516901 aaatgaacgc aaaatttatc gacgaggaga tcacaacact tccaaacgga taccgttatt 3516961 tctatatcga aggccctgac ggtgagtgga ttgagttctt tcagcggtaa aaataaagaa 3517021 cgtacatttt gtgatgtacg ttctttttta tctataccaa ctgatatacg ttgactcatc 3517081 gcaaatcata gcttcccagc ccatacgctc aaccaattca tggatgtttt tatctttggc 3517141 taaaaagaca ttaatgaatg agtcatatac actcataaac acaaaatcca ttttctcatc 3517201 agttaaaacg agctctgttg cggcttcatc aagaaccgtc cgcaagttgg cttcagttat 3517261 gtccaaaacg ccgcggtttt ccacaatcgg ttctgcgtaa taaaaccgat tggatccgtt 3517321 cgcacctaat acctttacca aactcggaat atgaaaattt gaaatatgat cctcactggg 3517381 ataatagagg tctccattta tgttttcatg taacacctca gccaaatcct ctctcgcgaa 3517441 ctcgtccctt aaagcgccta tcgacgtcat taaagccagc gccagctcag catgtgtttg 3517501 aaagccgcaa gaagacataa ccttcttcca ggaaacagcc ttgcctattc ctcttatttc 3517561 attatcgttt ggataaatat gttcataatc attttttctt tttgcattct cccatccttc 3517621 aggcatttgg ataaaaggag aaaagataag agcagcagat gagtattcaa ctggtacttg 3517681 ttgtaagatt ggtgattcgt catctaacca tatataatct agcatgcgca cctcctttac 3517741 atattctaac attcctttcg tttgaaagag atgatcagcc ctatgacagg ctgatcatct 3517801 atcacatcac atttttatcc ccagattcaa ccgcactctc ttcccgccat ttttgatgat 3517861 cccatattct gaaaaacgga tagtagatag cacaggtgat cagcagattt accagctgca 3517921 taactgcgcc cgacaccttt ccgcctgtcg ccaggtaacc tgatatgagc ggcggcatcg 3517981 tccatggcac cgcgattccg gccggtcttg ccaccagccc ggtgctcatg ccgatataag 3518041 tcgcggtaat cgtgaggagc ggtgcgatga taaatgggac aataaggagg ggattcatga 3518101 caatcggcat gccgaaaatg atcggctcgt tgatattaaa tagcgcaggg ccgattccta 3518161 atcgtccaag ctgcttcatt tgtttgctgc gggagcgcac aagcatcgtc aggacaagcg 3518221 ccagcgtcgc cccgcttccg ccgacattga tccaaatttg aaaaaactga gtcgtaaaaa 3518281 tactcggcag cgcctcgcct gcttggaagg cgagacggtt ggcatccatc gcgccgtacc 3518341 aaatcggcgc catgattccg ccaatgatgg aagccccgtg aatcccgcac gaccaaagca 3518401 gcatctgcac aaattcagcg atcaggcttc cgccgagact gccgccaagg atggaaagcg 3518461 gtgtgccaag caggtctcct acgacattgt gcagactctg aaaaggtgtc atttcaatca 3518521 gaagacgcgc cagccatacg agaagcacaa tgataaagcc gggaatcagc gcgacaaatg 3518581 atttgcttac cgcaggcggc acaccgtctg gcattttgaa gacgatattt ttttgaataa 3518641 tgtaccgata gatttcggtt gaaaacaagg cgatcagcat ggcgacaaat aagcccttgc 3518701 tgccgagcag cgtgatcggg attccgcccc ctaccatgat ggactccgtt gagccatgcg 3518761 gtgtaaacgg cacctcaaac ggtgttgcca gcagaaatgc ggcaattgaa atcgctccgg 3518821 cagaaagggc atcgacacca tagctttctg ccagccgata ggcgatccca aaagcggcaa 3518881 tcatcgccat aatatcaaac gaagcgttaa caggatatcc gagcttatcg gcccactcgt 3518941 tcccaaacac actcgccatg aaatcagcat accccggaat cggcaagctc gttaaaatca 3519001 agaagacaga cccgataata atcagcggca tggtcaggat aattccgtca cgcaaagcgc 3519061 tgagatgccg ctgcccggca attttcccgg cgacaggcat tattttttcc tccatcaccc 3519121 gagtgaatgt gctcatctta aaaaccccct tttctcattg ctttgtgaac aacctccgca 3519181 atgttttctt tatcttattt tgaaaacgct tacaaattca tttggaaaat ttcctcttca 3519241 tgcggaaaaa atctgcattt tgctaaacaa ccctgcccat gaaaaatttt ttccttctta 3519301 ctattaatct ctcttttttt ctccgatata tatatcaaac atcatagaaa aaggagatga 3519361 atcatgaaaa acatgtcttg caaacttgtt gtatcagtca ctctgttttt cagttttctc 3519421 accataggcc ctctcgctca tgcgcaaaac agcagcgaga aagaggttat tgtggtttat 3519481 aaaaacaagg ccggaaagga aaccatcctg gacagtgatg ctgatgttga acagcagtat 3519541 aagcatcttc ccgcggtagc ggtcacagca gaccaggaga cagtaaaaga attaaagcag 3519601 gatcctgata ttttgtatgt agaaaacaac gtatcattta ccgcagcaga cagcacggat 3519661 ttcaaagtgc tgtcagacgg cactgacacc tctgacaact ttgagcaatg gaaccttgag 3519721 cccattcagg tgaaacaggc ttggaaggca ggactgacag gaaaaaatat caaaattgcc 3519781 gtcattgaca gcgggatctc cccccacgat gacctgtcga ttgccggcgg gtattcagct 3519841 gtcagttata cctcttctta caaagatgat aacggccacg gaacacatgt cgcagggatt 3519901 atcggagcca agcataacgg ctacggaatt gacggcatcg caccggaagc acaaatatac 3519961 gcggttaaag cgcttgatca gaacggctcg ggggatcttc aaagtcttct ccaaggaatt 3520021 gactggtcga tcgcaaacag gatggacatc gtcaatatga gccttggcac gacgtcagac 3520081 agcaaaatcc ttcatgacgc cgtgaacaaa gcatatgaac aaggtgttct gcttgttgcc 3520141 gcaagcggta acgacggaaa cggcaagcca gtgaattatc cggcggcata cagcagtgtc 3520201 gttgcggttt cagcaacaaa cgaaaagaat cagcttgcct ccttttcaac aactggagat 3520261 gaagttgaat tttcagcacc ggggacaaac atcacaagca cttacttaaa ccagtattat 3520321 gcaacgggaa gcggaacatc ccaagcgaca ccgcacgccg ctgccatgtt tgccttgtta 3520381 aaacagcgtg atcctgccga gacaaacgtc cagcttcgcg aggaaatgcg gaaaaacatc 3520441 gttgatcttg gtaccgcagg ccgcgatcag caatttggct acggcttaat ccagtataaa 3520501 gcacaggcaa cagattcagc gtacgcggca gcagagcaag cggtgaaaaa agcggaacaa 3520561 acaaaagcac aaatcgatat caacaaagcg cgagaactca tcagccagct gccgaactcc 3520621 gacgccaaaa ctgccctgca caaaagactg gataaagtac agtcatacag aaatgtaaaa 3520681 gatgcgaaag acaaagtcgc aaaggcagaa aaatataaaa cacagcaaac cgttgacaca 3520741 gcacaaactg ccatcaacaa gctgccaaac ggaacagaca aaaagaacct tcaaaaacgc 3520801 ttagaccaag taaaacgata catcgcgtca aagcaagcga aagacaaagt tgcgaaagcg 3520861 gaaaaaagca aaaagaaaac agatgtggac agcgcacaat cagcaattgg caagctgcct 3520921 gcaagttcag aaaaaacgtc cctgcagaaa cgccttaaca aagtgaagag caccaatttg 3520981 aagacggcac agcaatccgt atctgcggct gaaaagaaat caactgatgc aaatgcggca 3521041 aaagcacaat cagccgtcaa tcagcttcaa gcaggcaagg acaaaacggc attgcaaaaa 3521101 cggttagaca aagtgaagaa aaaggtggcg gcggctgaag caaaaaaagt ggaaactgca 3521161 aaggcaaaag tgaagaaagc ggaaaaagac aaaacaaaga aatcaaagac atccgctcag 3521221 tctgcagtga atcaattaaa agcatccaat gaaaaaacaa agctgcaaaa acggctgaac 3521281 gccgtcaaac cgaaaaagta accaaaaacc tttaagattt gcattccaag tcttaaaggt 3521341 ttttttcatt ctaagaacac cacacacaac ctttttccca tccattgtac aggcttttca 3521401 tactattgct atacagccat gaacagcata aaatgaacgt tattacagtt atcaccacat 3521461 atggcgggat tgtgactggg caggcaggca agacccaatg atgcaaaggg agtattaatg 3521521 cctaaaaaac agggcatttt aactcttctt ttcgtgttgg gctcataacg gcgccttgga 3521581 caacccccta ttctcatgct ccgtcgtcga cgcgggcatt tttgtcattt tcagccggta 3521641 tttctcactt ttttcatttt gattgtcaac ttttcatttg atacgatgaa caagccgact 3521701 tttcttcagc aaaggaggtt ttaattgctt gcataaagag attgcaaaag aattactgct 3521761 gctcgcagga ggaaaaaaca atattatcag catcagccat tgtacgaccc gtcttcgttt 3521821 tgatgtaaag gacgagacga aaattgatat acatgccatt gagaacctgc aaggtgtgca 3521881 gggcaccttt ttccgctatg ggcttttcca gattatcttc ggagcaggcg tcgtcaacaa 3521941 aatatataaa gaagtcgttc atgtatggga gaccgcgcct tctgaagagc ctgtccacca 3522001 gaaaaaagcc agccggaagc tgaaccctgc cgcagctttt gcgaaaacac tgtccgatat 3522061 ttttgtgccg attattccgg caataacagc aagcggcctg ctcatggggc tgatcggcat 3522121 gattaaggtg tttcattggt tcgctgccgg cagcccatgg attaaaatgc tcgacctcgt 3522181 gtccagcaca gcctttattt tactgccgat tttagtcggc ttcagtgctg cacggcaatt 3522241 tggcagcaac ccatacctag gggcagtgat tgcagggctt ttgacgcatc ctgatctgct 3522301 ggacccgtct atgctcggca gcaaaacccc gtcttcttta gacatatggg ggcttcatat 3522361 cccaatgatg ggctatcagg gttccatgat accgattctt ctttccgttt ttgtcatgag 3522421 caaaattgag aagctattaa aatcgattgt gccgaagtcg cttgatgtcg tgatcattcc 3522481 ctttattacg gtcatggtga cagggtgcct cgcgctgatt gtgatgaatc ccgccgcgtc 3522541 catcatcggc cagatcatga cacaatcgat cgtctatatt tatgatcacg ccggcattgc 3522601 tgccggagct cttttcggcg gcatctactc caccatcgtc ctatctggat tgcatcatag 3522661 cttttatgca attgaggcaa cgctgcttgc taatccgcat gtcggtgtca actttttagt 3522721 gccgatatgg tcgatggcga atgtggccca aggcggagcg gggcttgcgg tattcctcaa 3522781 aacgaaacaa tcaagcctga agaaaattgc gctccccgct tctctgaccg cgtttttagg 3522841 cattgttgag ccgattgtat tcggggtaaa tctcaaattg atccgtccct ttatcggagc 3522901 agccatcggc ggtgctattg gcggagcata cgtggttgcg gtacaagttg tggcaaattc 3522961 ctacggactg acaggcattc cgatgatttc aatcgtgctg ccgtttggcg ccgctaattt 3523021 tgttcattat atgatcggtt tcttgatcgc agccgtctct gcttttatag ctacattgtt 3523081 tctcgggttt aaagaagaga cagaataact ggatttattc gatttcattc ataaaacggg 3523141 ggatgaaagg acaaaaaagc tatgaaaatt aaaagaatct taaatcataa tgctatcgtc 3523201 gtaaaggatc aaaatgaaga gaagattctc ttgggtgcag gaattgcgtt taacaaaaag 3523261 aagaatgata ttgtcgatcc gtcaaaaata gaaaaaacct ttatcagaaa agatacacct 3523321 gactataagc agttcgaaga gattttagaa acattgcctg aagaccacat tcagatttct 3523381 gagcaaatta tctctcatgc cgaaaaagag ctgaacatca aaatcaacga gcgcattcat 3523441 gtcgcttttt cagaccatct ttcttttgca attgaacgcc tgagcaatgg gatggttatc 3523501 aaaaatccgc tgctgaatga aatcaaagtc ctttatccaa aggagttcca gatcggctta 3523561 tgggccagag cactgattaa agataaactg gggattcaca ttcctgatga tgaaatcggc 3523621 aatatcgcca tgcatatcca cacagcaaga aacaatgccg gcgatatgac acaaacgctt 3523681 gatattacaa caatgatccg tgatattatc gagattatcg aaattcaact gtctattaat 3523741 atcgttgaag ataccatctc ttatgaaagg ctcgtgaccc atctccgctt tgccattcag 3523801 catatcaaag caggcgaatc catttacgag ctggacgcag aaatgattga catcattaaa 3523861 gagaagttta aggatgcctt cctgtgtgcc ctaagcatcg gcacctttgt gaagaaggaa 3523921 tacggctttg agtttcctga aaaagaattg tgctacatcg ccatgcatat tcagcggttc 3523981 taccaacggt cagtcgcacg ctgagacaaa caaaaaacgc ttttgatcat ctcaaaagcg 3524041 tttttttatc tgatttattg gttgatcgcc ggattcccaa tcgtattcca cttcgtatag 3524101 gacatgtaat ggaaatactc atcgcgatac ggatgttttg tattggagtt ccaaggcttt 3524161 tctccgccgc agaagtgcac gattgccggg ttttctcttg tttcattata ttgcttccgc 3524221 cctaacagag tcgatggggt tttcagcttt aacatgatat aggtttgagc gttccagcgc 3524281 ggatgaagtt cataccactg atcatacaag atcgcattca gtgcatcttg gtcatgcagc 3524341 acaagaaagt cttcgtctgg gtgttcattg ataaagttga tgactttttc tgtgatgttt 3524401 tgctttctcc aagactcaaa atcaataatc atgatacctg agttaaaata cttccctgta 3524461 tcagtgacgt tcatttcttt caggcgttca tgctgccccg catcctcaac agcggctacg 3524521 gtgtatggcg caatgtctaa gtcccatagc ttagaaatat cctctaggac aagcgcatca 3524581 caatcgatgt aaatcattcg tttgatgctt tcatccttaa ttaagtcggg aatcgaaatg 3524641 cggtaatacg cggcttttgt aatatggctg ctctcaaccg catgttcata catgttggta 3524701 tccacttcta aaaactcaat cggcactccg aatttcaaag tggtttcttc cagtcttttt 3524761 ttgttatcag gcttaattcc gccatcaatg acgtataatt ttacctctct ctcctgatcc 3524821 atgttagtca ataaagaaac gaacatccca cctaaatgac gagcataatt atcatctgcg 3524881 catgatacga tatgcatgat ttcatctttc ctcaatggta ttcatctccc tttttgttgt 3524941 acaagttaca tacccttttt caaaaaaata aacacgttct ccgacatttt tttaaacaga 3525001 atgtgtgata caacaaaaaa ggtgtcattt tttgaagatg cgataaagcc aataaagaat 3525061 gaaaaagctt gcgattgtga tggcttcagc cgagacgata taccacggcc atggcccgag 3525121 aacatctaag agagaggaac cgcccggttt tttcgtcaaa tacatataat tcgcgccaag 3525181 ccagcgatca atcagaaaaa tacagacgcc gtacacatta acaagcagga ctgtcaccca 3525241 taacgagcgc tggcccattc tgtaggtgcc aatcacagcc atcagcagac aggataaaaa 3525301 cacagacccg tgagaaataa aaaagaggat atatcggata tgcggaaatg aaaacatacc 3525361 gaggtcagga gtggcaagag cctgaatcga actgccgatg ccgacaaaaa acaaaaacac 3525421 aaacagcttt ctgctttttg tcactaacat aatagctgac aaatacaccg acaggtcact 3525481 aagctggaga ggcaatgaag tgcgcaccga ccacctgtcc gtggcgacca tccatatttg 3525541 atagccgatt tgcgaaccaa gcaaaagaaa cacaaacaga gaacgcaaaa accggctggc 3525601 cctcggctgc ttgacctcat cttggaacaa aaacaacaga atggccaaaa gggagataat 3525661 cgctaacgtc actacatgct ctgtcgaaaa cagatgaaac ggatcatgct tatagtcgga 3525721 ttgaacatat ttttgcaaaa ctgcaccccc gttttcgggt ttttgtttat tttggcgttg 3525781 tttgggcttt ttttattcaa ccgatatatg ggcttgaagt tcacaccaga ctctgttaaa 3525841 attcgtttca tagctaatga ttctgataat ttaaggcagg cctaaaaaat ggaacgttca 3525901 catcaacatc agcagcttcg gaaggaagaa cacgatacac tttctaagct caaacaaatg 3525961 cccgtcgagt cactcaacct ggaagccatt tcgatcgcta cgaatctgta tcggtctgca 3526021 caaaggctcc gtgtcaaaat ggagactgag gttctttcta cctataacct ttcttggacc 3526081 gctttctcca ttctttatga tctatgggta tggggagcgc tcgaaacgag aaaaatcgct 3526141 gagctgtcag ggatatctac agctacagca agcaacgtga tcaaaacgct cgaaaaaaag 3526201 agtttttgcc gtaaaagcat cgacacaaga gatcggcgac tcgtgtttgt ctcaatcacc 3526261 gattccggca aacaagcgat cgaagaactc tacccggagt ttcacaaagg ggaaacagag 3526321 ctcattgcgg gaatgacgaa ggacgaacag aaaatattga cagggctgct tagaaaggta 3526381 gctgacaatc ttcatacaac ataagctttg acgggaatcc agtagcggtt tgtctccctg 3526441 tttcagagag ccggcggtag gtgcgagccg gcgcacaggc aaacgtgaat tacctcccca 3526501 agctttcttt gtgaacctta gtagcaaaga acgggaaacc gttattcgaa tgagcggaag 3526561 acaatgtctt caaccagggt ggtaccgcgt gcattgagcc acgtccctta ttgggatggg 3526621 ctcttttttg tgtttgtaaa aaaggaggaa aaatgatgag aacatttgag cagctcacag 3526681 cgtcacaaca aaaagaggta gaaagacagc ttcagctata catgacaggc gcccacgaag 3526741 tcataccgcc ggaggaatta aaggcaaagc tcgtgaaatc aatttccacg ggcacgccgc 3526801 ttaaaattaa gctcggatta gatccgtctg caccggatgt acatttgggc catacggttg 3526861 tgttaaataa gcttcgccaa tttcaagaaa acggccacat tgtccagctg ttaattgggg 3526921 atttcacagg aaaaattggt gatccgaccg gaaaatcggc agccagaaag caactgactg 3526981 atgaagaagt tcagcacaat gccaaaacct actttgagca attcggaaaa gtgcttgatc 3527041 cagaaaaagt cgagcttcac tataactcaa aatggctgaa aacattgaat ctagaagatg 3527101 tcattgaatt agcagggaaa ataacggtag cccgcctgat ggagcgcgac gactttgaag 3527161 aacgcatcgc catgcaaaaa ccaatctcac tgcatgaatt cttttaccca ttgatgcagg 3527221 gctatgattc tgtcgttctc gaaagtgata ttgaattagg cggaacggat cagcatttca 3527281 atgtcctcat gggacggcat ttccaagaac gatacaacaa agaaaaacaa gtcgtcatcc 3527341 ttatgccgct cttggaaggc ttggatggcg tcgagaaaat gtcgaagtcg aaacacaact 3527401 acattggcat taacgaacat ccaaacgaca tgtacggaaa aacgatgtca ctgcccgaca 3527461 gcctgatgaa aaagtacatc cacttggcga cagacttaga gcttgaagag aaaaaacagc 3527521 tcgtaaaaga cttagaaacc ggcgccgttc atccgcgtga tgccaaaatg cttttagcca 3527581 gaacaatcgt ccgaatgtat cacggagaga aagcagcaga agctgccgaa cactcgttta 3527641 aaacagtctt tcaggaaaac agcctgccgg aagatatacc ggccgtaaac tggaaaggcg 3527701 aaaaaacgat agcgatgatt gatctgctcg tcaagctaaa gctcctctct tcgaagagcg 3527761 aggcgcgccg catgattcaa aacggaggtg tacgcatcga cggagagaaa gtaacagatg 3527821 ttcacgccaa agcagagata agagagaata tgatcatcca agtcggcaaa cgcaagtttt 3527881 taaagctcca ataatctgat attccgaaac gcttatgacc cttcattcat aagcgttttt 3527941 ttgcaggtat aaagcactgt cttttcaaaa acgctctcca tcttgcagga aactccttta 3528001 gcatcccgaa atattcccca accatacatt taggggaggt ttatttttga tgaaaaagct 3528061 tttgactgtc atgacgatgg ctgttttaac tgccggcaca ctgctcttgc cggcacagag 3528121 tgtcacccct gccgcgcacg ctgtacaaat atcaaatagc gagcgcgagc ttccattcaa 3528181 agcaaaacat gcgtactcta ccatttctca gctaagtgaa gcaatcggcc ccagaatagc 3528241 cggaactgca gctgaaaaaa agagtgccct attgatcgcc tcatcaatga gaaaattaaa 3528301 gcttgatgtg aaggttcaac gattcaacat tcctgaccgg cttgagggta cactgtcttc 3528361 agcaggacgc gatattcttc tccaagcggc gtcgggctca gctccgactg aggaacaagg 3528421 gctgacggcc ccgctttaca atgcgggatt gggctatcaa aaggacttta ccgctgacgc 3528481 caagggcaaa atcgccttga tttccagagg agacctgact tattacgaga aagccaaaaa 3528541 tgccgaagcc gccggagcga aagctgtcat catttataac aacaaagaaa gcctcgtgcc 3528601 tatgacgcca aacctgtcgg gaaataaagt cggcattccg gtcgtcggca ttaagaaaga 3528661 agacggcgaa gcacttaccc agcaaaaaga agccacctta aaactaaaag cattcacaaa 3528721 ccaaacctcc cagaatatca tcggaatcaa aaaaccaaag aacatcaaac atccagacat 3528781 tgtgtacgtg accgcccatt acgacagtgt tcctttttcg cccggagcaa atgacaacgg 3528841 ctcaggtacc tctgttatgc tggagatggc gcgtgtctta aaaagcgttc catctgataa 3528901 agaaatccgc tttatcgctt tcggcgccga agagctcggc ctgctcggct cctctcacta 3528961 tgtagatcat ctatcggaaa aagagctgaa acgaagcgaa gtgaacttca acttagatat 3529021 ggtaggcaca agctgggaaa aagcgtctga gctgtatgtc aacacattgg atggccaatc 3529081 taactatgtt tgggaatcca gccgtacggc tgctgaaaaa attgggtttg acagcctgtc 3529141 tctgacacag ggaggatcat ctgatcatgt gccattccac gaagccggca ttgattccgc 3529201 taactttatt tggggagacc cggaaacaga agaagttgag ccgtggtatc atacccctga 3529261 agactcgatc gaacatatca gcaaagaacg cctccagcaa gcaggcgatc ttgtgacagc 3529321 cgctgtctat gaggctgtga aaaaagagaa gaaaccgaaa accattaaga aacaaatgaa 3529381 ggcgaaagca tctgacattt ttgaagatat caaataaaaa aagacggcac ttgggtgccg 3529441 tcttttttaa tccacttctt tcttaatccc cagcattttc tcatctaggt aatgggcaat 3529501 ctccgcggct tctttcagct catctgttaa ttgcttagga acgtcattgt tcaatttata 3529561 ataaatttta tgttcaaggc tcgcccagaa atccatcgcg attgtccgga tttgaatttc 3529621 tgctttgacg tattccacac ggttcgttaa attcacaggc atctcaatga ttaaatgcag 3529681 gcttcgatag ccattcggtt tgggtgtctg gatataatcc tttaccttta cgattctcaa 3529741 atcttcatgc tgcttcaaca cattcacgac attataaatg tcagaaataa aggaacagat 3529801 gatgcgcacg ccggcaatgt cgtgaatatg ctccttcatt tccttcgtcg taatctcaca 3529861 gccctttctc attaacttat tcacgatgct ttcaaagctt tttacacggg attttgtatg 3529921 ttcaatcggg ttgtgtccgt gaatgaggtt atattcctgg ctgataattg agaactttgt 3529981 atcgagcgca tctagcgcaa atttataaac taataactca tttttccaat cttccattac 3530041 tgtttttaaa tcgtccatat gtgttacaga taaatccatg ttcgtcatct cctttaacgg 3530101 aactttatcc gctgtccatg tactagacgt ccctgtctgc tgcaaggttc tatgaatttt 3530161 tttacaaaat gcggtcgatt gtaacaaaaa aagaccgcat gaaacgagcg gtctttttta 3530221 ttatcggaaa tagctgatca ataatccgat cgagagcagg aatccgaaaa atgtatttgt 3530281 ttgggctgtt gatttcattg cgacaatcat attcatcggc atttcgttct ggacgaagcc 3530341 cttcactgcc tgaaccggct taggcacgct caaaaagacg acaaacagcc atgggcttgc 3530401 ggcaccggta ataaccaagc cgacaaccca gatataagcg acggcaaacg acgcagctaa 3530461 cagagtaaca gctcccttat gccccatcaa aatcgccaat gttttgcgtc cgcctttttt 3530521 gtcctcttca atatcacgaa tgttgttcga caggttaatc gcgccgacaa gaatcgcaat 3530581 cgggatggaa atcaaaatgc tctgcatatt gatcttatct gtctgaatga aaaacgaaat 3530641 cagcacaaac accgaaccca tgcaaatgcc tgagaataat tcaccgaacg gcgtgtacgc 3530701 aatcggcagc ggcccgcctg tatacaggta gccgatcgcc atgccgacaa ggccgatcag 3530761 cgcaagccac cagctgctgc tggcacaaat atagacaccg agcaaaatgg caatcccgta 3530821 tgaggcaaga gctaattgca aaatcgtttt aggcttcatt ccgtggcgta caatggcccc 3530881 tccgattccg actgattctg ctgtatctaa tccgcgttta aaatcatagt attcattaaa 3530941 taagttcgtc gcgatctgga tccataggca agaaaacagc atagccaaaa acagcagcag 3531001 atcaaccttc acataaaaca tcgccaaaac ggttccgagc agcacaggca caaacgatgc 3531061 ggttaacgta tgaggacggg ttaactgcca aaggatctgc cccatgcttt ctttttgcgg 3531121 cgctgtctga ccctcaccct tatttgtttg gttcatcttc ctcttccttt ctattaaaag 3531181 gcttactttt tttcagccgg cagcttaata aaaaactcct tttgcttcct tatctatcat 3531241 aatgacttct cccttatttc acaagatacc gcaagaaggc gttttctttc ttattatacg 3531301 cttctcgccc tgatttcatt aggtttctgc tttcacttga acgaacaggt acagaaaaat 3531361 ttttttaagt acattacact ttttaaaagt taaaaagatc ttttgactcc aggtatcttt 3531421 tcctttatta tgaatcagct cgaaacattc cattcttgcc cttgcaggta taaagattca 3531481 ttttcaaaaa catacgccga tatattaatt tgagggagat tagggaaaaa atgaaacttt 3531541 ttgagcatct gatcgtcaaa taatcatgtg attgtcgaaa aaacgggaag ggaatttttg 3531601 atatgctgca attaatgaaa cagctgtatg aaaaacccgc tgtcaagtgg acatgtcata 3531661 caggctttta tttgatgata ctgcttgttt tgttttttat gtatggtttt cacaccgcga 3531721 ataccggttc atatatttat aacgatttct aattggagag agaataacta tgaaactttt 3531781 acatgctatt caaacacatg cggaaactta tccgcaaacc gatgccttcc gctctcaagg 3531841 ccagtcgctc acgtatcagg aattatggga gcagtctgac cgcgcggctg ccgcgatcca 3531901 aaaacgcatt tctggggaaa agaaatctcc tatccttgtg tacggccaca tggagccgca 3531961 catgatcgtt tccttcttgg gaagtgtcaa agcgggacat ccttatattc cggttgacct 3532021 gtctattccg tccgaacgga ttgcgaaaat tatcgaaagc tctggagcag aattgctgat 3532081 ccatgcagca ggactctcaa ttgatgcagt cggccagcag attcagacag tttctgcgga 3532141 agaactgctg gaaaacgaag gcggctctgt cagccaagat caatgggtca aagaacacga 3532201 aacgttttat atcatttaca cttccgggag cacaggaaat ccgaaaggcg tgcagatttc 3532261 cgctgcgaac cttcaaagct tcacagactg gatttgtgca gactttccag tcagcggagg 3532321 aaaaatattt ttaaaccaag cgccgttctc atttgatttg tctgtcatgg acctatatcc 3532381 gtgccttcaa tcaggcggga ctttacattg cgtgacaaag gatgctgtga ataagccgaa 3532441 agtcttattt gaagagctga agaagtccgg gctgaatgtg tggacatcaa caccttcctt 3532501 tgtgcaaatg tgcctgatgg atccgggttt ttcacaggat ctgctgcctc atgcggacac 3532561 atttatgttt tgcggagagg ttcttccggt ttctgtggcc aaagcgctgc ttgagcgttt 3532621 tccgaaagcg aagattttta atacgtacgg cccgactgaa gcgacagtgg ctgtcacatc 3532681 ggttgaaatt acgaatgacg tcatcagccg cagcgaatcg cttccagtgg gcttcgccaa 3532741 accagatatg aacattttca ttatggatga agagggacag ccgcttcctg agggagaaaa 3532801 aggagaaatc gtcattgcag ggccgagtgt aagccgaggc taccttggtg agccagagct 3532861 gacggaaaaa gcgtttttct ctcatgaagg ccagtgggca taccgaactg gcgatgccgg 3532921 ctttattcaa gacggtcaga ttttctgcca aggacgtttg gattttcaga ttaaacttca 3532981 cggctatcga atggagctgg aggaaatcga gttccatgtc agacagtcac agtacgttcg 3533041 ttctgctgtc gtgattcctt atcagccaaa cggaacagtt gagtatctga tcgctgctat 3533101 tgtgcctgag gagcatgagt tcgagaagga attccagctg acaagcgcta ttaaaaaaga 3533161 gcttgccgct tctcttccgg catatatgat cccgagaaaa tttatctatc aggatcacat 3533221 tcaaatgacg gctaacggca aaattgaccg aaaacgcatt ggcgaagagg ttcttgtatg 3533281 acgccttaca gctcgttttt attctttata ctgcttggca ttcttcttct gccgacgatc 3533341 attctcggct taaacggaaa aagatttcaa gcatacaaca tgttcatatc tatcattata 3533401 ttggctttaa ttttttcgca cgacttacac ggggtcatcg cgctgtgcct gtttacaata 3533461 tggcaggtgc tcctgatcag cggctatctg gcataccggc agaaagcgaa cagcggcttt 3533521 gtcttttgcg gagctgttat cgcgtctatt ctgcctttat ttctgtcaaa aatatggccg 3533581 tttctttcac acccgcagcc gcatcatccg ccgcataacc tgatcagctt tttagggatt 3533641 tcatatttaa cctttaaagg cgttcagctg attatggaag caagagacgg actgctgaaa 3533701 gaacagctgc cattgcaccg tctgctgtat ttcatcctgt ttttcccgac gatttcctcc 3533761 ggcccgatcg acagataccg ccggttcgtc aaggatgaac agaaggcttg gacgaaagaa 3533821 gaatacgccg acctgctgta tacgggaatc cataaaatct tcatcggttt cctgtataaa 3533881 tttattatcg gctacgcgat caatacgtac ttcatcatga atcttcccgc aatcacgcac 3533941 aataagattc ttgggaacct gctgtacatg tacggctaca gcatgtattt attctttgat 3534001 ttcgccggct acacgatgtt tgccgtcggg gtcagctaca ttatgggcat taaatcacca 3534061 gaaaacttta ataaaccgtt tatcagtaaa aatattaaag atttctggaa tcgctggcat 3534121 atgtctctgt cattttggtt cagagattat gtgtttatga gattcgtatt ttggatgact 3534181 aagaaaaagt ggatcaaaaa ccgtatggcc gtctcaaaca tcgggtattt cctgctgttt 3534241 atgctgatgg gggtttggca cgggctcgcg ccgcaatata tcatttacgg cctctatcac 3534301 gccgttctga tgacgtgtta caactttttc gagaagtgga ataagaaata taaatggctg 3534361 ccgtccaacc gctggacaac cattctcgct attgtgatca cattccattt cgtttgcttc 3534421 gggttttata ttttctcagg aaaaccattt catcaccacc attaaaggag attagaaagc 3534481 tatggatttt aaacaagagg tattagacgt tttagcagag gtttgccagg atgacatcgt 3534541 aaaggaaaat cctgatattg aaatttttga agaaggtttg cttgattctt ttggaacagt 3534601 agaattgctg cttgcgattg aaaaccgttt tgatatttta gtgccgatca ctgaatttga 3534661 ccgggacgtt tggaatacac ctaacaacat tgtaaatcag ctgtctgagt tgaaataatg 3534721 aaaaagcgtt ttttcggtcc aattattttg gcgtttattc tattcgcagg cgccatcgca 3534781 attccatctt catggctgac aggcttcatc accgataagc gtgtgaaaga gtcagcaaca 3534841 gccttgaatc cgagtatgtt tcaagggcta tatttacaag atcagatgct caaagatccg 3534901 acatatcttc cgatttacgg gtcttctgag ctttctcggc tggacgagtt ccacccatct 3534961 aattattttc aggtaaacaa tgagggattc acgccatacc ttgtcggcaa aggcggatcc 3535021 cagtcattga ttcattcttt aaacttcgct gcccacatgg atcagctgaa gggcaaaaaa 3535081 atcgtattca tcgtgtctcc gcaatggttt attaagcgcg ggtctgatga acagcatttc 3535141 gcgccgaact attctgcgct gcaagggctt gatttggcat ttaacgatca gatcgatcct 3535201 gaaattaaaa agaaaatgat gaaacgcatg cttcgcttta aggctgtgca aaacgatgcc 3535261 attctttctg agctgtacaa agcaatggta aacggtcaga cgtggaaagt gaacgcgctg 3535321 aagccggcgg cgaaagtgta ttacagcatg ctggaaaaga aagatctgta ttattcaacg 3535381 acagaatcat ccgggccaaa gcgctatatc tcgcagtcag taaaggataa gtcatggtct 3535441 gaattgaata aactagcgga tcaatcgggc aaacgccact ccggttctaa cgattttcac 3535501 atcgacaacc ctgtctataa aaagctgaag ccgaaagtgc ctaagctgaa agggaaaaac 3535561 aaaggaagat cgtatgcggt gtcaccggaa tatggcgact ttgaaatgat gctcgatatc 3535621 ctgaaggatg cgggcgcaga gcctatgttt gtcaccattc ctgttaacgg gaaatggtac 3535681 gattacacgg gcttcccgaa aaaaggacgc actgactatt acaaaaaggt aaataaacaa 3535741 atcagagcga agggcttcca ggttgctgat ttctcagggc atgaatatga cccgtatttc 3535801 atgaaagaca ccattcacat cggctggaaa ggctgggtgt atgtcgataa agcaattgac 3535861 gaattttata aaaccggaaa agtcacttca tcctgagcat ctcataggac gcggctgcat 3535921 atttcctgct aagatttgta atagtaaagg aatcacagcc aacttaatta agaggtgtta 3535981 catccaatga agatgacaaa taatacggtt ttaatcacag ggggttctgc tggcatcggg 3536041 cttgaactgg ccaagcgcct gctggaactt ggcaatgaag ttatcatttg cggacgcagc 3536101 gaagcacgtc ttgcagaagc gaagcagcag ctcccaaaca tccatacaaa gcaatgtgat 3536161 gttgcagacc gttcgcagcg ggaagcattg tatgaatggg ctttaaagga atatccgaac 3536221 ttgaatgttc tcgtcaacaa cgccggcatt caaaaggaaa ttgactttaa aaaagggaca 3536281 gaggagcttt ttgtggacgg tgatgaaatt gaacttaatt tccaagcgcc tgtccattta 3536341 tccgcccttt tcacacctca tttgatgaag cagcccgagg cggcaatcgt tcaggtcaca 3536401 tccgggcttg cgtttaaccc gttagctgtt tatccggtgt actgcgcaac aaaagcggca 3536461 cttcactcgt tctcgcttac gctcagacac cagctccgcg acacgagcgt ggaagtgatt 3536521 gaaatggcac cgcctatggt ggacacgggc ttaaaccaaa aatcacgcga taaacaaggc 3536581 ctgacgtacc ggggcatttc atctgaagaa tatgttcaat atttcttgga cggcttgaag 3536641 gaaggcaaac aggagattac aaatgaacgt gttgaaggtc ttcgggatgc cactcgcgcc 3536701 gattatgaca ggttattcga gcaaatgaac acgcaggaga attaatttct cctgcttttt 3536761 tcatatgaat ttcttacaaa tttgagcaaa cctattgcga ttatttgttg aaggtataca 3536821 atagaatata attattttca aataagtttg ataatataaa caatttaaca gcagggagat 3536881 tgaccatgac taaacaaaca attcgcgttg aattgacatc aacaaaaaaa ccgaaaccag 3536941 acccaaatca gctttcgttc ggaagagtgt ttacagacca catgtttgta atggactatg 3537001 ccgcagataa aggttggtac gatccaagaa tcattcctta tcaaccctta tcaatggatc 3537061 cggctgcaat ggtctatcac tacggccaaa ccgtgtttga agggttaaag gcttacgtgt 3537121 cagaggatga ccatgttctg cttttcagac cggaaaaaaa tatggaacgc ctgaatcaat 3537181 caaacgaccg cctctgcatc ccgcaaattg atgaagaaca ggttcttgaa ggcttaaagc 3537241 agcttgtcgc aattgataaa gactggattc caaatgcgga gggcacgtcc ctttacatcc 3537301 gtccgttcat catcgcaacc gagcctttcc ttggtgttgc ggcatctcat acgtataagc 3537361 tcttgatcat tctttctccg gtcggctctt attacaaaga aggcattaag ccggtcaaaa 3537421 tcgctgttga aagtgaattt gtccgtgcgg taaaaggcgg aacaggaaat gccaaaaccg 3537481 caggaaacta tgcttcaagc ttaaaagcgc agcaggtagc cgaagagaaa ggattttctc 3537541 aagtactctg gctggacggc attgagaaga aatacatcga agaagtcgga agcatgaaca 3537601 tcttcttcaa aatcaacggt gaaatcgtaa caccgatgct gaacgggagc atcctggaag 3537661 gcattacgcg caattcagtc atcgccttgc ttaagcattg gggccttcaa gtttcagaac 3537721 gaaaaattgc gatcgatgag gtcatccaag cccataaaga cggcatcctg gaagaagcct 3537781 tcggaacagg tacagcagct gttatttccc cagtcggcga gctgatctgg caggatgaaa 3537841 cactttcgat caacaacggt gaaacaggag aaatcgcaaa aaaactatat gacacgatta 3537901 caggcattca aaaaggcgct gtcgcagacg aattcggatg gacgaccgaa gtcgcagcgc 3537961 tgactgaaag caagtaagaa aaaagccggc ccattacagg ccggcttttt ttacgcttca 3538021 attttgttga aaaactgcgg cagatacgct ttgtgcgcct ctagcatttc gtctaaaatc 3538081 tgtttggcca cagtatcgga cgggacaagc gggttaatcg tcatggcaag gagcgcagtt 3538141 tgatagtcac ctgtaactgc cgcttctgcc gcgacacgtt caaaggattt gatttgctgg 3538201 acaaggccgc ggacagacac cggcaagtcg ccgacagcaa ttggcttagg gccggttttc 3538261 gtcatcacac agttcacttc aactgcggaa tcgtctggaa tactcgctat tgcaccatta 3538321 ttgatcgtgt tcaccggctg aatgtcatgt ttatcattat aaatggagct gattaagtta 3538381 catgctgcat cactgtagta agctccgccc cgtttttcca gctgcggcgg tttgatcgca 3538441 aggtttggat ctttataaag ctcgaacagc tctttttcga ccttctgtac gacttcagcg 3538501 cgggtgccct ccgtttgtga tgcttccagt tcgtgctcca gcatctcttt tgttttaaaa 3538561 tagtaacggt gatagccgca agggatgaca ttgagcgctt ttaagaaatc cggttcccat 3538621 tcggcgcctg agatattttt catcgtcatc gcgtttttcg ggtcgcccat cgcctcgatg 3538681 acttgctcct tcacacttac gccgtccaag aaaacatcca gcccgaatac catatggttc 3538741 agtccggcaa attggacttc tacgcggtcc acatctacat caagcgcttt ggctacgccc 3538801 attttgatgc cgattggaac attgcaaaga ccgacgactt tcttcaggtt ggagtagcga 3538861 agcaaggctt ctgttaccat gccggcaggg tttgtgaagt taacaagcca agcgttcggg 3538921 caaagctctt ctatgtcctt tgcgatctca aggatgaccg gaattgtgcg caatccttta 3538981 aacagacctc ccgggccgtt tgtttcctgg cctatcactc cgtattttag cggaatgcgc 3539041 tcatcctttg ctcttgcctg caaaagtccg acgcggaatt gggtcgtgac aaagtctgcg 3539101 tctttcagcg cctttctccg gtcgagcgta agatgaatgt caatcgggac gccagctttt 3539161 tcaaccatcc gtttggcgag tgtgccgaca atattcagct tttcttcgcc ctcggggata 3539221 tcgacaagcc ataattcacg gacaggcagc tcatcatacc gtttaatgaa cccctccact 3539281 agctcgggcg tatagcttga acctccgcca atcgttacaa tcttcaatcc ttttgtcata 3539341 tgcttgctcc cctttgctcg gtgatttttt catataactc aatgatctct gcagccatat 3539401 ccttcactgt cattgcattc attaaatgat cctgtgcatg aaccatcaga agcgtcattt 3539461 ccgtcttttc tccgcccgct tcattttgga tcagctctgt ctgataatga tgggcttttg 3539521 acaattcttc agcagcgtct tgaagctttt tccgcgcttc ttctgcgtca ccgcttttcg 3539581 cagcggcaat ggcctccatt gcggagctcc taccgtttcc tccgtgaagg atgatttgaa 3539641 aaatgatttg ttccatttcc tcattcacgc gattcacttc ctttctctac agagccgctt 3539701 ctttgtcatc tgttgctgca ggcgtttgga ccagctccag atcgttttct tctttcagct 3539761 tctgcttatc ccacattctg aagaatggat agtagacaac aaaggacacg gcaatattaa 3539821 tggcttgcat gaccgcgcct gagacttttc ctcctgtcgc caagtagcct gaaaagatcg 3539881 gcggcatggt ccacggcact gcgatacccg ccggtttggc gacaaggccg gtgctcattc 3539941 cgatgtacgt gagtgtcact gtgacaagcg gcgtgatgat aaacggaagt aagagcattg 3540001 ggttcatgac gatcggcatt ccgaatataa tcggttcgtt aatattgaag atggccgggc 3540061 cgaccgcaag cttcccgagc tgcttcattt gtttgcttcg ggcgcgcagg aacatcgtga 3540121 caaccagtgc caatgtggcg ccgcttccgc caatattgac ccagatatcg aaaaattgct 3540181 gggtgaaaat cttaggaagc tcctcaccgg cttggaatgc gatccggttg gcatccattg 3540241 cgccgtacca aatcggtgcc atgacgccgc caacaatgtt tgcaccgtga aggccgcagg 3540301 cccataaaag cattttgacg gcttcggcga caaggcttcc tccaaggctt cctcccagaa 3540361 tggaaagcgg agtccccaat aaaacgctta caatattatg aaggctttca aacggtgtcg 3540421 cttcaacaat cagccgggct gcccaaatta ggaagatgac ggcaaagccg gggattaacg 3540481 cgacaaatga cttgcttacc gccggcggga caccgtccgg cattttgaag actaaattgc 3540541 gctggataat aaggcggtaa atctctgtgg acaccattgc gataatcatg gcgacaaata 3540601 agcctttgct tcccatgagc gaaagcggaa tcccgccgcc aaccatgatt tctttcgtcg 3540661 cgccatccgg cataaacggc acttgataag gtgttgctaa taaaaatgcc gcaagggaaa 3540721 tggctccggc cgacaaggca tcaacaccgt atttctcggc gagccggtag gcaatgccga 3540781 acgcggcgac aagacccata atttcaaagg tcgcgtcgac tgggtaggcc agtttttcag 3540841 accaggagct gccaaacgtt tttgccataa actcagcgta tcccgggatc gggaggttgc 3540901 caatgatgag gaaaaaggaa ccgatgataa tcaggggcat cgtgaggatg ataccatcac 3540961 gcagcgcctg caaatgacgc tgtcccgcaa ttcttcccgc tataggcatg accttttctt 3541021 ctaagatctg attgacttta ttcacatagc ccgcccctct ctatgacaca tgtccaagct 3541081 gttcagctga tttcagcact tccgccccat tgcacgttcc ataatggacg gtattaatga 3541141 cgtctaccgg aacccccttt gactctccta attttttgag ctgcggaagc atgtaacgga 3541201 cttgcggacc gagaagcaat acatccgctt tatcgatatg attttgtaca gaatcgcctg 3541261 aaactgccca aatggtatag tcttttccct gttcctgcgc acttttttcc atcttgctca 3541321 ccagtaagct agtagacatg cctgctgcac aaacgagtaa tatattcatg taaaagaccc 3541381 cctagagttt gatcaatttt gtaatgtcct gctgttgcta tcatcatatt atgaaatcgc 3541441 tttcataaac actcagggtt tttccgcagg caacggaaaa aaggtatata caggctgtca 3541501 gctcagcatt ttttggtcaa acacatccga aagctcttga tatgaacggc atttgatcag 3541561 ctggttcatc gccgccgggt catccaaaat gctgccaagc agtttataca tgctttgtaa 3541621 atccgctttg ttctcctttt cgacacaaag cagacagaca aattgaactc gctgactctc 3541681 ccaatcgatc ggttttttga gcgtacaaac ggcccaaaac gttgttttcg tctgcggaac 3541741 aagcgggtgc gggatggcaa caagattgcc aaaacacgtt ggcgacatgt cttctctttc 3541801 aaaaatggaa tctatgattt cttcatcggc aaagccgcat tcgaccactt tctgccctaa 3541861 aaattgaatc acttcttctt ttgagcgcag atcctcctga aaaaaaacga gttctttttt 3541921 taggtagcga ttggcttttt ccttttcatc actcagaata gattctattt ttgtaaagtc 3541981 agttccgcct aagatggtgt taaccttcag tactggtaca gggagctctt ttttaatcgg 3542041 aatggtgctg atgacaaaat caattgattc gtaggacatt tgatcaagac tataatactc 3542101 agccgttcca agaatatcga gccgcttgcc gaaatgggaa cgcagttttt cgcgcagaag 3542161 ctgggcgctt ccggctcccg atgcgcatac aatgatacag cgtttcggcg ggctttctgt 3542221 tttttttcgt tcaatcgcgg cgccaaagtg gagagccaaa tatccaattt cgttttcatg 3542281 aatctcaata cccgtttgtt cctttatcac gattccggca atgatcccgg cttcaaaagc 3542341 gagtggataa tgttccttga tcgctgccag catcggattt cgaagattca tgccgtatcg 3542401 gttgcggctg atcgccggct tcatatgcag tgccaagccg attttcagct ctttgtcatg 3542461 caggatgcca agcttcagtt cacgatcaac agctttgatc atggcaagtg tcagctgatc 3542521 ggtttcctct tctattgaaa atgtgtcctc tccgcattgt gattgtgtca ttcgttttgt 3542581 gccaaggaga tgcatggtga tgtaggccgt ctcgtctttc ggaaacgtaa cggaaagctt 3542641 tgattccagc tcttttacga tggcttctgc agcctggtac tccttttgat gcaggatatg 3542701 atccatatct ttcgggaaaa gagaaacata gttttccgtt ctgatccgtt tacaggcgat 3542761 agcgatatgg ataatgaggt tattcagtcc catgttggac agagggatgc ggtcgttttt 3542821 catttttttc aagatggcgg aacggatgat ctcaatttct tcttttggca aaatatcagc 3542881 cttttcattt aaaacatcta tctccgtttc tctttcatca acaatgtact ccgccatgca 3542941 gtacctcatc tgcacctcgt ccccgcgcag cttgaagccg taattcggac gtgtttccat 3543001 gacgatgcgg taaggcagca gacgtttctt tacttccttt aaatccgttt ggagtgtaga 3543061 ttttgagata aatagttctt cagcaagttc atcgagcttg agataatggt ccgccagcag 3543121 cagacgtttc ataagatagg ccattctctc ctccggcaat accggcaggc cctttttttg 3543181 ctgaaattca tcttgcagca gtgttctgaa tacttgctcg tcatcaatgc ggagcttgta 3543241 gccggagcct cttacagatt gtacaaaggc accgtggccg cttagcacac cttgaagttc 3543301 ctttatatca ttgcggactg tccgcgtcgt tacgtttaat tgcgcggcaa aaaacgaact 3543361 tgtcaccggg gcttcagccg ccatcagcaa gcgcagaata tcacgtagtc gcccatgaag 3543421 catgagaaaa acctcctaac tagtagatgc agggattcag tgaataggca gaaaggatga 3543481 tgaagggatg cgaaatgtat ataaattcta taatggagag aatggcaagt caatgaacat 3543541 ccggaggact agagggaaaa ctgacctata aaaaaacagc cgggatcagc cggctgttct 3543601 agatgcggac atattctttt gtttagacgc cttgcggtcc ttcatgattt ttcgaacaat 3543661 cgggtaaatg accggcgccc atttgataac ggttttgatc atctttttca aagctccgat 3543721 tctcccttct tttttctcaa ccattcccct gattgcctct tccttaaaca tgctaacgcg 3543781 acacgtacct gtttcccgtc acccagaaac gccatggata atcgcgtgcc tccccgctgt 3543841 tgtcaatgcc gatgcgcggg ccggttgaaa ttgcttccgg tgtgtacccg ctttcgatgt 3543901 aaagcggctg ttccgtgatc cagcgtccgt agtcattcat cgtgacgcca agcgctttcg 3543961 tcagctttcc tggtccgttt gtccattccc tcggactcct gcccggcctt ctctcctcca 3544021 ttaacagctg gccttcatgc ggctcaatcg ccctgattaa tactgcttgc gggacatcct 3544081 cttccgccgc aacgacattc agcaatgtat gggtgtgcat cacgtatgta tatacccgcc 3544141 cagcttctgc aaacatgatc tcagtccgct tcgtccggcg gttgttaaag ctgtgggccg 3544201 ctctgtctcc agcccccata taggcctctg tttccacaat atagcctgac gctgtgcctt 3544261 cgtctgtttc ttttacaaga aggcagccca gaagcgatgg ggcaagctca agagcggttt 3544321 tttgataaaa cgtgatgggc agcggatttt tttctctcgt cacgaatcga cctctccttt 3544381 taccgatttt tgtacattgt accattcccg aagcagatca aaaaaaacgg ctgttttaaa 3544441 atctttccat tcagggaata ttgttaccgt tcaaaaaagg agggccaacc attgaaagat 3544501 gatcatcaaa acaagcagca ccaatcaaat gcccaaggga gcgaggaagc gttttctcat 3544561 aagacatccg ggaaaaacga gtcagaggat accttaacga ataggcaggg gcatcctgtt 3544621 actgacaacc agaatgtgag aaccgtcggg aatagagggc ctacaacact tgagaactat 3544681 gattttctcg aaaagatcag ccacttcgac cgggaacgca tcccagagcg ggttgttcat 3544741 gccaggggag caggtgcaca tggatatttt gaagcgtacg gaagcttcgg agacgaaccg 3544801 atttcaacat acacaagggc caagctcttt caggaaaaag gcaagaaaac accggcattt 3544861 gtccgttttt caactgtgaa tcatggaaaa cactcgcctg aaacattgag agacccgcgc 3544921 ggttttgctg taaagctata tacagaagac ggaaactggg atttggtcgg aaacaacctg 3544981 aaaatctttt ttatccgcga cccgctgaaa tttccggatc ttgtacacgc atttcagcct 3545041 gatccagtga caaacatcca ggatggtgaa cgtatcttcg atttcatttc tcaatctcct 3545101 gaagcgacac acatgatcac cttcttgttt tcgccttggg gcattccggc caactaccgg 3545161 caaatgcagg gttcaggcgt acatgcctat aaatgggtga atgaggaggg caaggccgtt 3545221 ctcgtgaaat accattttga accgaagcag ggcatccgca acctgacaca gaaggaagca 3545281 gaagagattc aagggaaaaa ctttaaccat gccacacagg atctatatga cgcgattgaa 3545341 aatggcgatt atccagagtg ggaagtatat gctcaaatca tgagcgatga tgagcatcct 3545401 gaactggact ttgatcctct tgatccaaca aaactgtggt ataaagacga tttcccatgg 3545461 aaaccgatcg gcaaattggt tctgaacaaa aatccggaaa actaccatgc ggaagtggag 3545521 caagcttcat ttggaacggg agtgcttgtc gacgggcttg atttttcaga cgacaaattg 3545581 ctccaggggc gtacgtttgc ctactctgat acgcagcgct accgtgtagg cgcaaattac 3545641 ctgcagcttc cgatcaactc gccgaaaaag catgtcgcca ccaaccagga aggcgggcaa 3545701 atgcaatatc gggtcgatag agcagaagga caaaacccgc acgtcaacta cgagccatcc 3545761 attatgggcg ggctgaagga agcgaagcaa gacggaaaag accatacgcc gcatgtcgaa 3545821 ggtgatgtaa agcgtgaagc gattgacaga acaaacaact tcggacaggc tggagaaacg 3545881 taccggagat ttactgaatt tgagcggaac gaattgatta cgaatttggt gaatacgctt 3545941 tctacgtgcc gaaaagaaat tcaggatcaa atgattgaga atttcacaaa agctgatcct 3546001 gactacggaa aacgcgtagc agaagggcta aaaaaggtct ccgaaaacaa cagcaacggg 3546061 ccgatcggca caactgaaac ggaacaggct gcaaagcagg ctgaacagga gagtcatccg 3546121 tctgatccgt attaacaaca gcgaacaggg cttttttaga agccctgttt ttttattttt 3546181 ctattgaaac gctttcaata attgtgttgt acttggaagg aaaggggtgg agagatacga 3546241 tggaattaca gcaggacttg attcctcaga aaaaaacaat cggcgcttta gatcacgccg 3546301 tttttttatg catggtattt tgtttctggt tttcaggcta tatttacgtt cctgtattca 3546361 gtctgtattt ggaggatctg cacttttcat atggcgcaat cggcatcatt ctcggcagct 3546421 acggggtcac gcaaatcctt ctgcgattcc cgctcggcct tttgtcagac atcctgtttt 3546481 ccttgcgcaa gcaattgtta attgccgggt tcggcttttc cgtcctcagc agcctgcttt 3546541 ttctgatgtt tgattctttc ttcttcgtgc tggccgcccg gcttttcgcg ggaatcactg 3546601 cttctacgtg ggtgatggcg accattttat acgcacatta tttcaacaat ggcaatgcat 3546661 caaaagcaat gggcatcatg cagtttttta ccgtcatgcc tcagtttgcc agcattgtgt 3546721 tctgcgggct cgccgcagcc catttaggga ggcaggttcc tttttggatg gcgctggcag 3546781 cttctgccgc aggtctggtg atctgctgct ttattcagga tccgtctgct cctcccgcaa 3546841 accgtggcac cattcgtgtc aatcagtaca tcaaagatac attgcggctg ccaaagctga 3546901 agcttttcac catcctgtct atgacggccc atgccgtatt atttatcaca gtgtttggtt 3546961 ttacgccgct ttacatgaat cagctcggaa tgggcgacgc ggagctgctt tgggtgatga 3547021 gcgccttttt cctcccacac gcagccgcca cattaagctt tgtgtttctg cgctttacaa 3547081 gccgtatcgc ttactccgtg atgctcatta gtttcgctgt caccggggtc tgtttgctat 3547141 atgttccttt tttagctgca ttgttcacgg tttgcatcac acacgcctgt attgggctgg 3547201 cgctcggctt cgtttttcct ctgctgctaa gccatgtcgt cgaaatcagt tctgcccgtt 3547261 taaaaatgtc agtgatgggg ttttaccaat cattttatgc gctaggcatc ttcctcgggc 3547321 cccttcttgc cggaaaaatc gcacagctta tcgggcttgc gggagttttt tatggagccg 3547381 gttctctggc atttgccgcc ttttttgtga tgctcgcgca aaaacgtaac atgatcaatt 3547441 aatagctttc ataccgccgg aagcgccaca cagaaaacac ggccagaagc atgatgcaca 3547501 gaatggagaa agtgagtgac catccgaaaa aatctgcccg ctctccatga agaaggatat 3547561 gctccgcctg cttgcaaatc tcagccggaa gccacttcgc accatctgga aatagtgaaa 3547621 cagcaaagga aacggctgct gtgagcccga tcccgcaagc cgcagctgct ccgacagacc 3547681 ggaatatcgt acttccggca aggccggcgg tcacaataaa tatcacccaa agagcgtaaa 3547741 ggccaaggct tgcggcaaag cggctgaatg atgcgtcctc aaacagcagc cggacgtaat 3547801 agtaagcaag cccgtatcca gctgcaaacg acataatgcc gatcacgctt tggatgagcc 3547861 atttactcac gatataatgg gctgccgtca caggccgcga cataatcagc gctgttaccc 3547921 cttgatttct ttcattggct acactgccca tcacgctaaa gatgaccaga gccatgccaa 3547981 gcgtgttgaa ttgagaaagc gtgctgacca tcacttcaga cccggagggc atcgtaaaac 3548041 tgattttcat gccgtcagga aggttccctc catgtgcgat gatttccggc atataataaa 3548101 tggtcagcgg ctgtgtcagc ccgacgatca tcatcgcaat cggcagccaa atcagcttgc 3548161 cgcttttcca tccttccagc cactccttct gcaatagcgc catcatcacc ttcatgcgtg 3548221 caccaccttt agatagacgt cttctagaga ctccgttttc tgttcaaagc gggtgacggt 3548281 caatcccttt cggatacagt cacttaataa tgaccggcca gcgtgtatat caggcagctc 3548341 gaaaaccgct tgggacggat tcttatagac aatagctgag acgtaaggct tctcttcaag 3548401 ccaaccttcc agcttctctt tcactgaaag ggtaaaaacg ttcgtttgct gctgttgttt 3548461 cagctcctgt aactcgcctt tccatgaaat ctcaccgttt ttcataatca ccacttgatc 3548521 acacacctgt tctgcatcgt gcaaaacatg tgtagaaaac agaacggcca tatgcttttt 3548581 cagctcccgc atcatgtcca gcacctcgaa ccgtcctgtc ggatcaagcg cagacaccgg 3548641 ttcatccaat atcaaaaact tcggtttatg gagcagtgcc tgtgccagac cgagtctttg 3548701 tttcatgcct cctgaatagc ccccgatcct tttgtgcgcc gcttcgtgca aaccgacaaa 3548761 ttccagcatc tcgccgattt tctcttggca ttttctcttc gaaaggccgg acagtctccc 3548821 cgcaaatgtc aaaaattcat ttgcggtcat ccacgaataa aaagcaggat actgcgggag 3548881 gtacccaatc aaacgccgat ccagcttttt ctctcctaac agctttatgg ttccagaggt 3548941 tggcgaaagc agtccggcca gcatttgcag agtcgtggtt ttgccggctc cattaggtcc 3549001 taatagtgcg acacactcat tttcattcac gtgaaaactg acattcttta cagcttcatg 3549061 gtgcctgtac gatttgcata atgattcaat agacagcata tcggcttacc tttgctttct 3549121 gccgacggtg aaaaataaaa tcggcccgat aatattgata catacgatga ttgcagccca 3549181 catccacttt ggcccgttcg tccgctcttc ttttatacag ctgataaggg caaacaccgc 3549241 caaagccagc tgtaatacaa tcagcggcaa aatcatttcc caagaaatat tcattgcttg 3549301 atcccccttt tcttccgatc cggcctaatg acaaaaaagt aataacaaat cagaggcatc 3549361 ggtgcttgaa tcaatccgac aatcccccaa acccatgcca tgtgattacg ttttttcgca 3549421 tcaataaata aaaagattcc ctgcgccaat acgatgagac aagccgcaac cgttatgata 3549481 atttctgttt gtgtcatccg cgtttcacct cgcattcgcc gagatgcctt tttttctcag 3549541 ccgcaatcaa aatcggcagc accgcaagca cacaaacctg aagcacaata aacacagcag 3549601 gagcttgagt gaaagctaag attgcagcac tcacaaccat cagcgcgcag aatacaaata 3549661 aaatgatctc ttgaagaagt ttttttctgt attcagcttt catttgtgac agctggtgaa 3549721 gcagttcttt ttgattcggt atagagggat tggctgtttg atcaattttt ttccattctg 3549781 actttaaatg atcagaaagc ttttctttat tcatcatccc actcctttct gatttgctgg 3549841 agccctttat gaactctgga ctttacagtg ccttctttga tttgaagcat caccccgatt 3549901 tcagcgtagg tatagccgta gtaatgcctt aataaaaccg gtgtgcgcag tttagggtcc 3549961 agctttgaaa acagatcgag cgtttcgctc cactctgccc ctttcgccga cacgtcccac 3550021 ttgatcttgc ggattgtttc ctccgtaact gtctgattcc gtttccattc tctctttctc 3550081 tttttctggt gatcgagata gagccgcgat gcaatggaga tcagccatgt ggagaatttt 3550141 gaacggccct gaaagcttct taaatggatg taccctttca gaaaggtttc ctgaacaagt 3550201 tcctcgctga gatcggggtg aagggaaagc tttaacaagt atttatataa gaaagaatag 3550261 tgatagtgga aaagggctgt aaacgcctcg tcgtttccct ctttcgcctg ctggatcagc 3550321 cgctgttctt cttgtgtatc caatgaccgt gatcccccct tttttgtttt tctgccttat 3550381 gagacgacac cggattcaaa agcgttcatc ttttttacaa ttcttttcag ccattgacag 3550441 atcaggcttc ccggccgttt ggctgcatat ccttatttgt aaaccccctt atagtctgtt 3550501 aagctatgac tttatgtcga tttcaaaaaa acatccaata tggaggacga tgcattgaaa 3550561 gtagaaaggc gaacgattga atatattccg aatgaagaaa gacatggtaa agcgaaagat 3550621 ttatttcccg tatggttcgg ggctaatatg catatcacca cgttagtgac cggcacgatt 3550681 cccgttgcaa tgggacttaa tctgttttgg agtgttgccg ctattatttg cggaacctta 3550741 atcggtgcca tatttatggc ttctcattcc gcgcaaggcc ctcagctagg catcccgcaa 3550801 atgattcaaa gccgtgccca attcggcgta atcggagcga ttcttcccct cttcttagtc 3550861 atgtttatct accttggttt cttcgcaagc agcacgattc tggcggccgg aaccttaagc 3550921 agctttgttc ccatcccggg atcatggagc attataggct taagtgccgt atgtttttta 3550981 ctcaccattt tcggccatga tttgattcac aaaatgcaaa aaatcctttc ttggacctct 3551041 tttgctgtat tttttgctgc aacgattctc atttttcaat tgccgattcc ggcaggcagc 3551101 tggatacccg gagcgattga tctgccaatt ttcctagtgg cagtcagcgc agttgcgacg 3551161 tggcagcttg cctacgcgcc gtatgttgcc gattattcaa gatatctgcc agttaaaaca 3551221 ccggcttcaa aaacattttg gtacagctat gcaggtacat ctgtcagctc catctggatg 3551281 atgctgctcg gcgcattgct gacaacctca cttcctgact ttacggcaaa ctcaggcagc 3551341 cagattgtcc aattgttcgg tcccttctcg tttattatgc tgatcattgt gctatttggg 3551401 caaatggcaa tcaatgtttt taacctgtat ggggctttca tgtccacgac aacaacgctg 3551461 gagccgtttc tgaaattaaa agtcacgccc aaagtcagaa tcatcatgat cctgggtgtc 3551521 acgcttgtcg gcacagtctt aagcctactg ggacagagca attttatgga actgtttttg 3551581 aattttatct ttttcatcag ttatttctta attccgtgga cggcaatcaa tttagtcgat 3551641 tactacttcg tccgccacgg aaagtatcaa gtcaaagcca tgttcgacgt aaacgggcct 3551701 tatggaaagg tcaattggat caccacaatt gcgttcgttc tgtctatctt gctggaaatt 3551761 ccgtttatca acacaagctt ttacatcgga ccgcttgcca aaatgtttgg cggcggagac 3551821 atcgcatgga ttatcggctt ggccgtgcct tctgtgcttt actatgtatt aatgaaaccg 3551881 cgtctgaaaa aacgggcggg gtatcaagaa aagctgtctt ctctctgaag acagcttttt 3551941 tatcattcaa atcgtttcca cacgcggggc aggatgtcag atagctcatg agcgagcaac 3552001 gtatgagcgg agtgctcgtc cgtccagagc tcggcgcacg caccatgcaa atagaccgcg 3552061 tttaatacgg cgtgctttgg atcttcatgg cagcagagca tccccaatat catgcccgtc 3552121 agcgtgtcac cggttccgcc cttggcgagc gccccgtttc cggttggatt gagccagcag 3552181 tctccatcag gaaacgcgat gacggtttgg tttcctttta acacaatgac agtctgcagc 3552241 tgagccgccc attcctttgc atattccgct ctttttttct gcaattcgtt cacgggcacc 3552301 cctgtcattc ggaaaaactc gcccgggtgc ggcgtgagga tgacggggcc ctcccgtttc 3552361 ggatatgtgc gcttcgccag cgctccggca tccaaaataa caggacaatc agccgtaagc 3552421 acatgatcga ctgcctgctg tacgctttcc gtttgcggaa ggcccggtcc gatggcaatg 3552481 gcccggtacg tctcttcaag ctgagcatcc gccgcctttt tccagccgtc acgccaatag 3552541 gtcgcctcgg gcaaaacagg aacaattagc gggattacgt tttctgatgt accgatgaca 3552601 agcttgccga gaccgctccg catggcccca agccctgcaa gcagcgctgc tcccggcatg 3552661 tcgtcacttc cagccagcag caaagccgta ccgtacgtgc ctttatggct ctccgcatct 3552721 ctttcaggaa gcgtggccct tacatgctct tccgtccaaa atggaacatt catctctatc 3552781 cctcctctgc tttcttttcc tatttttcct gtcccttttc tttttcaaac aaaaaagaca 3552841 gccttttagg gctgtctttt attttacagg aacatcaagg tgatacaggc ggcgatatcg 3552901 ttcgtttgcc gccagcagct cctcatgggt tccttccatt tctgttttgc cgttttcgag 3552961 aaatacgatt ttatcggctg cttccactcc cgcgagatgg tgtgtaatcc ataaaatcgt 3553021 ttttcctttc agcacctcaa acaccgtttc catcaattca cgttcggtaa taggatcgag 3553081 gccgactgtt ggctcatcga ggatgatgat cggtgtatcc tgcagcaaaa tcctcgcaag 3553141 tgcgatccgc tggcgctctc caccggaaaa acggatgccg gtttcttgta cagaggtatg 3553201 atatccgtca ggcaatgact caatgtagtc atgcagcttg acctgctttg cggcgcggcg 3553261 cacatcctcg tcgcttgctt ctccgtttcc gagcctgatg ttgttcaaaa tgcttgtatc 3553321 aaacaggtgc ggtttttgat ttaacacggc caccgcatcc gcaatctgat cctttaacag 3553381 cgctgtctcc actccgttta acgtcacaga accggagtcc ggtttcaagg cgccttcgat 3553441 taatgcaagc gatgttgatt tcccagagcc gcttcggccg agcagcgcca ttttttctcc 3553501 ttggcgcagc gtaaaggaaa agttgtgcag cacttggctg ctgttgtcat aagaaaacgt 3553561 cacatcacga aaggccaagg tgacatcttg aagatcgaga atttgatccc ctgattcagt 3553621 ttgtgacgcc tccggctgag gagccacatt gttcatgcgt ctgatagaat cctgatagcc 3553681 cggcacttcg cctaaggcat ccgaaagcgg caaaaaggct tccgtcaacg gaaacaccac 3553741 tagcacaaaa gcggcaatca tcgttttagc gagctcgccg tccgcttgct gtcccgctgt 3553801 ccaaaacagc atcagcaaaa taaggccagc gacaaggcat tgcgcagcaa agtcccgcca 3553861 tcttgtaaag cgttgttttt tccgttcaag ctcaaaccaa tcacgttcct ctttttcata 3553921 agcatcaata aaagcatgcc ggcgtccgct gaacatccag tcgctgacac ccatcacagc 3553981 atctgtcaga cggctgtaca gcacattccg tccgcttttc agcttcgcat tcttcgctct 3554041 cgtcacgagc aaagacacaa ccggaaacaa tacaacaaga acaaacaaat acagcgcaag 3554101 caatatggca aacggccaag agaagaagcc gagcgctatc actgacacag catacaggag 3554161 caaggctgag atcgcaggaa aaatcgtttt taagaaagca tcctgcaaat gctcaatatc 3554221 ctcagacaaa atgccgagca tatcccccgt gcgaaaacgg gaacgcagca tcaaagcacc 3554281 cggctcaagc atattgtaaa ggcggacgcg catgtcagat acgattttca aaatgatgtg 3554341 atggccgacg agccgttcca catatcgcga cacagagcgc gcaatcccaa aggtgcgcac 3554401 agcgacaatc ggcacataaa tgagcagaat gttttccggc cttgtcgccg ctttagaaat 3554461 caaaaaacct gaggtgaaca tgagaaaagc agcagaaaaa atcgtcaccg cacccaaaaa 3554521 gataaccaga acgaacaggc gggcattttg cttgatatac ggcaaaatcc attcttcttt 3554581 cttcatgctc tttcccccag ttgtgccttc acgagtttgg tatacacacc gtttttctcc 3554641 agcagttcat tgtgagtccc aatttccgca accctgcccc cgtcaagcac gataatttcg 3554701 tccatatcga gcatccagtg aaggcggtga gtcgcgagaa agacgagctt atcctcaaat 3554761 aaatccagca tcgtttcttt tatttcatat tctgtttcga tatcaagatg ggcggtcggc 3554821 tcatccagca gcaggatcgg acggtttccc aaaaaggcgc gggccagcgc gacacgctgt 3554881 gcctggccgc cgctgagcgc ccggccgcct tccccgatcc gcccctctaa tccgtcagga 3554941 aggttgttca ccagctccgt cagtcccgct gaggcagcag cacgtgttgt atcctctgcc 3555001 gaagcgcttg gatggtagaa gcgaatgttg ttgccaagcg tatcatcaaa aatgtacgga 3555061 tgctggggaa tgtaaagaag gttcttctgc cagctgccgt cctgcaaatg ggaccggctt 3555121 gtaccattaa cctcaatcat cccgccatcc ggctctaaaa atccgccgag aatatcaatt 3555181 aatgttgatt ttccggcgcc gcttgcaccg ataatgccga tttttttctt gcctttgaat 3555241 gagagatgaa tatcagacac cgaacggccg actgacacgc ctgacagctt cagctcatcc 3555301 tgatcggacc aagcttcgag ctgaagcggc gtctcttctt taaaaccagg ctgcgacaaa 3555361 atctcttgaa tggtttttcc tgcttcctgg ccgttcagcg ttgcatgata atcattcccc 3555421 acttcccgca ccggcaaaaa atactcaggc gccagaataa gcgccgttaa agcagggcca 3555481 agcaaaatat cgccgtcaat gaggcgcagg cccagaaata ctgcgactgt cgccaccgac 3555541 agcatcgtga aaaaatcgag ggcgaatgat gacaaaaacg ccacccggag tgtgctcatc 3555601 gttgccttgc gataccgctc actcacatag aaaatatttt tgctgtgtga cttgctcaaa 3555661 cctaggaaac gcaatgtctc cagcccgcga agagaatcaa caaaatgatt ggaaagtctc 3555721 tgataggatt tccactgacg atccgctttt ctctgcgcga caaggccgag gagaatcata 3555781 aagatgatca gaatcggcat agcagcgact aaaatgatgg ctgatgtccg atcctgaaaa 3555841 aacacataaa tgacaactgc cgcaggcaca atcgccatgc tgaccatttt cggcagaaac 3555901 agctccaggt agcggcggaa ctggctgatg ccttccatcg ccagcgtcac catttgcccc 3555961 gtcccctctt tctttgcaaa gcgggggcct aatcggaaca gctgatcaag aaaacttttc 3556021 ctcaaatctg ctcctgtccg ggcggcgtat tgatagacga ttttctgtcg cgccaccgtc 3556081 atcccgtgcc gggcgataaa agcgatgagg aaaaagccga tcaccggtaa aagggaggta 3556141 atgcccttcc cgttgaacag tccggttacg gcctcactca gccactctgc ctgcataata 3556201 atggcggctg tctgaatcaa cgttaaacaa gtaatcaagg tgagaatccg cttcattcct 3556261 ttatatcgaa acaggtcttt tcccattaat aagtcatagg ctccttatgg ctgacgcgct 3556321 tccggaagac ataatagctc cagatctggc tgccgatgac gaacggcaat agcgttaatg 3556381 ctgcaattga catgacttta agcgaataat ctccagaaga agcgttagct actgttaaat 3556441 cgtatgcgct atgaagcgag ctgaccatta cacgagggaa tagggaaata aagatcattc 3556501 ccacggtcag cgccagacca gcgcctgtca tcccaaatgt ccagccgtct tttttcttac 3556561 gaataaatac agccgcgagc ataaagcaga tgacaatcaa aacagcgagc ggaatggtaa 3556621 tctcgccgcg gcgtgtaaac atgtctgtct gatacgcaga aagggccgcg aaggcaagaa 3556681 ccgctacaaa aacaacaccc attatctttt gcgccatttt ccgggcgcgg ttttgcaaat 3556741 caccaatcgt acgcagcgtg ataaacatta atccatgctg gaagcaaaga agcgttaccg 3556801 tcacaccgcc aagtatagaa tatacattga tataatcaga tacatgtgcg tgaatgttca 3556861 tgtcggcatc aatcggcatc ccgcggaata atgtcgtgaa cagcacacca agcacaaacg 3556921 gaggaattag actgccgaaa aaaacgaccc agtcccaaac ctttacccat tttaaatgat 3556981 ccaccttgcc gcggaactca aacgcgaccc cgcggcccat taacgcaagc agcactatga 3557041 caaacggaat gtaataaccg ctcagcatcg ttgcatacca gtttgggaat gccgcgaaaa 3557101 tggcgcctgc gccagtcaaa agccacactt cattcgcgtc ccagaacggc ccgatcgtgt 3557161 tgatcagcac tctgcgttct aattcattat ggccaagaaa acgggtcgcc atgccgaccc 3557221 cgaaatcaaa gccttccaaa aagaagaatc ctacaaacaa tacagcaacg agtataaacc 3557281 aaagatcatg aagagatgcc atggtatacc tcctgactaa atggatctgt tgatacaggc 3557341 acatcatgat gattatcatg ctccgcacct tttttaatct cacggataaa caagaagaca 3557401 agcagtgcac caagaatcat gtacatcaca ccgaatgcga tgattgagaa taacaaggaa 3557461 cccgctgtta cgttaggcga cacagattga gcggttgtca ttaaccccat aaccgtccaa 3557521 ggctgacgtc cgatttctgt cataatccag cccgcggagt ttgcaagaaa cgggaaggaa 3557581 atcaacgcga tcatgatgcg caaataccat ttgctgtttt caagcttttt acggcggttt 3557641 aaccaaaggc cgcctaacgc agcaagaatc atgacaacac ctgctcctac catgatgcgg 3557701 aagctccaga atgtcgtttt cactggcgga atgtagtcgc cttttccgta tattttttcg 3557761 tactcagcct gaagggtttt catccctttg acacttccgc tgaatttctg ataagccaag 3557821 tagctcaagg cataaggaac tttgatttca tttgagcttt tttcattttt tgtatcgatc 3557881 gtcgcaaaag cggtccaagc agcagggtca ccgctgtctt cccataggcc ttcactggca 3557941 gccattttca tcggctgtga ttccatcaag tgctcagcct gcatgtgtcc gctaaggccg 3558001 acgccaagac cggcacaaag accgacgatc attgcgagtt taaaagattg cttaaagaac 3558061 ggcacttctt ttttcttcag cagtttaaaa gcactcactc cggcaataaa gaaagctcca 3558121 gtggcaagcg caccgaaaat aacgtgcggg aattcaaccc aaagctgagg gtttgtaatc 3558181 aacgcgccaa aatcattcat ttccgcgcgg ccgtttttga tcgtaaagcc gaccggctcc 3558241 tgcataaagg agtttgctgt taaaatccag aaagatgaca tgatcgttcc gaatgatacg 3558301 agccatatgc agagcgcgtg aattttcttc ggcaggcggt cccagccaaa aatccataat 3558361 ccgataaaaa tagattccat gaaaaacgcc aataatgctt caatcgcaag cggagcgcca 3558421 aatacatctc cgacaaaacg ggagtaatct gaccagttca gtccaaactg gaattcttgc 3558481 aaaatccccg ttacaacacc gactgcgaaa tttattaaga ataagtgtcc ccaaaacttt 3558541 gccattttga gatacagctc atttttcttt acaagataaa gagtctccat caacgcaacc 3558601 ataaacacaa gcccgataga catcggcaca aacaagaagt gaaacaacgt tgttgatgca 3558661 aattgtatgc gggctaatac caattcactc atgctttctc ctccatttcc ggttaaaact 3558721 gttaatttgc tcactacttc acaaatagaa ccgagacttt gatcagtaat tcacaaaata 3558781 gacgaaaaaa atattgctca atatttcaca aatgtgtcaa aaagtcatcc aatatgatgc 3558841 aagattgcca gactgaccaa atgacacaat ctctgactgg ttcatattaa gtactttaca 3558901 acgattcatt tcaaaaataa agcctaaaat acctaaaaag tcccgcacta tgtgacggat 3558961 ttttgtctat tttgttgctt atttatgtcg gctgctagga taaatgaccc tttattatcg 3559021 tacatcaaca catcgttcct tgcgaacaaa atgcttgccc ccgccccagc actcgagtct 3559081 cagcattccg tcttaaaccg attttagtca gaatgcctct tttcatttga accggtaaga 3559141 ggagaaaagt tgaatagtaa atttttaata tattaataat ttcaattttt tagtatactt 3559201 aacatagtga acaatttcac tgcatcaaga ataggggagg tttttcaatg ggagagcttc 3559261 aaacacacat gcaattgcaa acggatacaa ttcacgaagg ggttcgaaaa gagaattggt 3559321 ttgcgaaagc catgaatata aaagtaggca tcataccgct tcctgtgtat gccttgctgt 3559381 ttatattaat cactgttttt gttatgcatc acgatgtaaa aagtgacatt ttgacatcca 3559441 ttgccgtcat ggcgtttttc gggtttacct ttgcccaaat cggcaaatcg ataccgattg 3559501 ttcgttctat cggcggcccg gccatcctag ctacttttat tccgtccgct gtcgtgtact 3559561 atcacctgct gcctaatgat atcgtcaaat ccaccacaga atttacagaa aactcaaact 3559621 ttctatattt gtttatcgcc ggtattgtcg tcggaagcat tctcggcatg aaaagagaaa 3559681 cactcgtaaa agcattcatg aaaatcttta ttccgcttat tgtcggttct gtcacagccg 3559741 ctattgtcgg actggctgtc gggacattgc tcggactcgg atttcagcat accctgctgt 3559801 acattgtcat tccgatcatg gctggaggag tcggagaagg cgctatcccg ctgtccatcg 3559861 gatattctga catcatgccc atttctcaag gggaagcgtt tgcacttgtt ctgccatcga 3559921 ttatgctggg cagcttgtgc gcgattattc tagcgggatt gctgaaccga atcggaaaga 3559981 aaaaaccgga atggacaggc aacggcaaag tggaccgctc cgaagaagag tcccctgcgc 3560041 tggaggaatc tcaaagcgga cagcaaatgt tcaacctttc tttatttgcg tcaggcggta 3560101 tccttgctgt ttctttatac ttagtcggca tgctcgctca cgattttttc ggttttccgg 3560161 cacccgttgc catgctgtta ctggctgttc taatcaagct gttcagattg gtgcctgcct 3560221 caattgaaaa tggcgcgttt ggagtgtccc gcttcttttc aacagctgtg acctacccgc 3560281 ttctctttgc gattggggta tccatgacgc cgtgggacaa gcttgtcgcc gcttttaacc 3560341 tcagcaatat tatcacgatt ctgtctgtcg ttgtgaccat gatggccgtt ggcttcttca 3560401 ctggaaaatg gctgaacatg tatccgattg aaaccgccat tattaatgca tgccattctg 3560461 ggcaaggcgg cacgggtgac gttgccattt taagcgccgc tgaaaggctt gagctaatgc 3560521 ctttcgccca ggtgtctacc cgcatcgggg gcgcgattac agtatcctta accttattgc 3560581 tgctgcacca gttttattga tccccgcaag caagttcttc gtcaaacgaa agagcttgct 3560641 tttttgcatg tccatgtttt tgcaagttcc catcccatgc tatagtaata gttggaaata 3560701 ctagatagaa aggaatctgg catgcctatg ggaactcatc tatttctctt tatgcttctc 3560761 gggctgggat tttatttgat atcagcccta gctgcaaaac tcattccggc catagacttc 3560821 tggattgata ttgttctatg ggtcggcgct gcggcttaca tcttctctca tctctcattc 3560881 atggacggca ttgtctcact cgcgacaatg ttctactgct attggaccgc aatggatctc 3560941 attgtttcag agcgtgtgga aaaaccttcg ggagactggc aggaaatcga gcttgccaaa 3561001 aacaaaacac gcctcctgtc agacattacg ctgaccgcca ttgtgtttgc aggggctgtc 3561061 atttttttca tctatggacc tgacacaagc cctctcaaat atgtgatcct tctcggaatg 3561121 atctccggcg gaggggcact tgtgaagcga atactgaatg tttttagcgt aaaggttttt 3561181 tattcagcag ccttagaaaa attgcatatc agctcacact atgaaacccg tacatacccg 3561241 ctttccgatt tgaagaacat tcagcttgaa tcaacagcag atctcttaaa gctccatccg 3561301 cttctgacga tgtattcatc ccgtttagat ttgacaacaa gctttcagca agtcattaaa 3561361 ctgtctcttc ccggcgaaac actgtttctg acggtgaagg aaccgcaaaa atggaaaaca 3561421 attcttcagg aatacacaga tgcagaaaac aatgtggaca atgtgatttc tgttttgccg 3561481 ttttatcatc gaaaaaatgt gaagcggctg ctcggtaagc tttattttgc cgccagcgta 3561541 aaaggggtat ccgcttacgc cttattggtg ctcgcgttat acgcattaca cgcctctcca 3561601 tgggtcatgg ctgttgccgt aatcctatat tgggtattca acatgtatat gtcagaccgt 3561661 gtgttgcggg cggcgatgga cgccaagtct tgtcatcatc cgcatgtaca ggccgcggcc 3561721 gataagattt tcagatcggc cggcatttcc catgtccgca tatacgaaac ggagagtgat 3561781 gattacaacg gaatggcagt aggcatgaat gtcgggaggt caatggtcat cctgacaagc 3561841 gccacactaa cacttccaca gcgtgtcatt gaaggcattc tggcccatga ggcgattcat 3561901 atcaaaaaac gtgacgttct gtcatcacag cttttgcgtt ttctatatct tggagctgtc 3561961 gtggggattt tcctcttgtt tgagcagcat atcacccatc ccgaggccca caaaattgcg 3562021 ctttgggctt tcattatggc aatcattatc ctattccagc tctatcaatc cttttgttca 3562081 caatggatgg aggtgcgtgc tgacaacctt ggcgcatcat tgctggacgg cggttacaaa 3562141 caaatggctg aagccttgag aatcttggcg gttcggcaag atgaggatat acagaaacaa 3562201 agtgcctata gctctgaagc aggtgaagac gagcttcaaa ttgattctct cacccgtgat 3562261 aaaagctggt ttttcagatt gattgatttt cagttcgctc ctcatcctcc tatgtattgg 3562321 cgtgtcggca ctttattgtc aaacaaagga catggggtgc taaagcgctg gctcagagac 3562381 cgactgaaag aatcgatcac tttgaaatga aaccggtcag cgtttcatcc gtataacaga 3562441 tatggtgaaa aaagggagtg acgcgaagtg attgtgatca tcttattgtt tatatctatt 3562501 attgtttttc tttcagtcat tcagccgcag ccctcgaaaa acaaaagccg ccagcaggcg 3562561 gacagcgggt atttcggtta ttcagatcat agctcacacc atgatggatg cagcagtgac 3562621 ggaggtttca gcgattccgg ctgtggcggc ggagggggcg gcgattaaac gccgcctttt 3562681 tttatttcat tgattcgatg tacgcaccaa aagccgagcc tgacatgcct ggggacacgc 3562741 gcacacgatg gagggcatac attccctggt ctctcgaagc cgcgcccggt tctgtcgtca 3562801 cgcccatttg atagcctgtt ttttcagcgg ccttcagcgt ctcctcattg tagcgcccta 3562861 ccggatagct gatgatggtg gtttgctgat gaaacatgtt gtcgaacagc tttttcgaat 3562921 cagccatctc actttgctgc tgttgaggcg ttaatccgtt cagctcaagg tggtcaatcg 3562981 tatggctttc aatcgatatg ccgtgctgtg ccatttcctt catttgttcc tctgtcagat 3563041 ggtgcttatg tccgatcgat ttgccgatca taaaaatcgt tgccttcatc ccgtactttt 3563101 tcagcaccgg atacgcatct tgataattgt cggtgtaccc gtcatcaaat gtgatcagca 3563161 cgcacttctc actcggtttt ttatcctgcg tcagcatgag agatgcctct ttcggcgtta 3563221 atgtctgata gccgttatca tgaagccact tcatatgcgc ctcgaattct ttctttggca 3563281 cacggaggct gtttcctgaa gaaatgctgt ggtacatcaa aatcggcagc tttgccggtt 3563341 tctctgtttt gatccatgcg gatgtatcgt cttctttttt ctgaacttgt actgcctttt 3563401 tttccggttt cttttgttcc gcttttggca tcggctgctc tgcattcgcc tcttgatcag 3563461 cacaagccgc aagagccaaa cagctgccca aaagaaagat gcttaaaaac aatcgtttca 3563521 tcgttctcct gctttctgtc tatttcttcc tcctttttca tcggtttgat tctgagattt 3563581 tcaatagcaa aaaaccggac atgtctccat gtccggtttt tttgatctta tcggattctc 3563641 acttctgtct cactgtcaaa gaaatggcct ttattcatat caaatgcaac cgtcagctca 3563701 tcgcccgatt gaatatcgag gcgggcgtcg atccgcgcaa taaagtcttg gttgtctatc 3563761 tgcgaataaa tcataatttc agaaccgagc agctctgcaa cattaatttt cgccttaatc 3563821 gaagagttct tatatgattc cacgacaatc aattcatcat gtatatcctc aggacggatg 3563881 ccgaagatga cctctttgcc gatgtagcct ttttcacgca gcactttcat ttttccttcc 3563941 gggacggtta atgccgcaga accgattttg attaagccat ccgtgagctt tcctttgaaa 3564001 aaattcatcg ccggtgatcc gataaacccg ccgacaaaga cgttttcagg gaattcatat 3564061 acatccttcg gcgtcccgat ctgctgaatt ttcccatctt tcatgactac aatccgtgtc 3564121 gccattgtca gcgcttctgt ctggtcatgc gtcacataaa tcgttgtagt ctgcaatctc 3564181 tggtggagct taatgatttc cgcccgcatt tgcaccctca gcttcgcgtc caggtttgac 3564241 aaaggctcat ccatcaggaa cacctttgca tcccgcacga ttgcccggcc cagcgcaacc 3564301 cgctgtctct gtccgcctga cagcgctttc ggtttacggt gcaaatattc ctcaagcccg 3564361 agaattttag cggcttcttc gactcttttt ttgatttcag gcttcggcat tttccgaagc 3564421 ttgagcccga acgcgatatt atcgtagacc gtcatatgcg gataaagcgc gtagttctga 3564481 aataccatcg cgatatccct gtcctttggc gctacatcat tgacccgttt tccttcaata 3564541 taaaaatcac ctttcgaaat ttcttcaagt cctgcgacca ttcgcagcgt cgttgatttc 3564601 ccgcagccgg acgggccgac gaatacgata aattccttat cggcaatatg aaggttaaag 3564661 tcatcaaccg ccggttcctt ctgatcataa aatttataaa tgtgctccat ccgcaattca 3564721 gccatctaac atcccccttt gttattgtaa acgctttctt atattgagtg taacagcaat 3564781 tccctctcgc taaaatgggc agcgttcata aaatcaccca gccatttttc gtgcatattt 3564841 ccaatttatt ctgaactttc attttgcagg cagataaaat aggcaagaag cgcgcctttg 3564901 tacgatttga tatctatccc tgaccgctca ataaatttat caatccgata ttgcaggctg 3564961 ttgcgatgca gatgcagctt tttcgctgtt aatgtgacgt ttgagttgtt ttcaataaac 3565021 agcttaatgg tcttccttag ctcagattca cttccaaata aaagctcagc ttcttcagag 3565081 agcagtgttt ccagtttttc tttttctgtt tctaataata gaaaaggaaa gatcatctca 3565141 aaggtcacac tctgcacctg aggcagccgt ttttcagcaa acaggaaata cgcctgttca 3565201 cgagcgtaat gttttcgcag acactcatcc ggctcgtaaa atcttccggc gtaaaaacgg 3565261 acactgaagt agaaatcact ttcaagaacc ttagcgagcg attccagttc gtccttctcc 3565321 gccgccgctt cactttcctg ctcgacaatc acacctctgt cctcatggat ccacacaatc 3565381 acaaaagaca ccggccaaaa atggcgaacc gcttccgtaa aggacgtcct ttctattttg 3565441 ccgaataaat gaaagtgaac aaatctcgtc cgtttcttta tatacgccgg caattcccct 3565501 ctggaaaaaa ggaacgaaaa ccacttgttt tcctcaggtg atttcataga cagttgattg 3565561 ccctcatccg caggcgtcaa aaatgactgc agcaccaata cttctttttc actgatctct 3565621 gttttcggaa tggagatata tctctgattg ctctcatcaa aaaaacatag acagccttcc 3565681 cttatgcaaa gctcctcaga cacaatcgaa ccgggataaa tagccagcag cgatttcata 3565741 gagtctcctc tcttatgtaa ggatctgtat attcagtata aggcgaaaca cacatgttct 3565801 ccactaaaaa agagtatatc cggtatagat agacgagaaa ctgaaaggga aacctcattc 3565861 gtttacatat tggcttcagc ggaaatagaa gaagacatgc aggaccaaag gagggtcatc 3565921 ttatgagttt cgaaacgtta aacaaaagtt ttatcaacgg aaaatggact gggggagaaa 3565981 gcggacgtac ggaggacatt ttgaatccgt atgaccagtc tgtgatcaca acagcatctt 3566041 tggcaacggg caaacagctt gaggatgcgt ttgacattgc acagaaagcc caaaaagagt 3566101 gggccaagag cacgacggaa gaccgaaaag ccgtgctgca aaaagcgcgc ggctatttac 3566161 acgaaaaccg tgatgacatc attatgatga tcgcccgcga aactggcgga acgatcatta 3566221 aatcaacaat cgagctggaa caaacgattg cgattttaga tgaagccatg acgtatactg 3566281 gtgaattagg cggcgtcaaa gaggtgccat ccgacattga agggaaaacc aataagattt 3566341 accgccttcc gctaggtgtc atttcatcga tttctccatt taatttccca atgaatctat 3566401 ccatgagatc cattgcgccc gcaattgcgc tgggtaacag cgttgttcac aagcctgata 3566461 tccaaactgc tatttccggc gggaccatca ttgcgaaagc gtttgaacac gccggtcttc 3566521 ctgccggtgt ccttaacgtc atgctgacgg atgtaaagga aatcggggac ggcatgctca 3566581 ccaatccaat cccgagatta atcagcttta cagggtcaac agcagtcggg cgccacatcg 3566641 gtgaaatcgc cggtcgcgcc ttcaaacgaa tggcacttga gctcggcggc aacaatccat 3566701 ttgccgttct ttcagatgcg gatgtcgatc gtgctgtgga tgccgcgatt ttcggaaaat 3566761 ttattcacca gggacaaatc tgtatgatta tcaacaggat catcgttcat caagatgtat 3566821 acgatgagtt tgtagaaaaa ttcaccgccc gtgtcaaaca gcttccgtac ggcgatcaaa 3566881 ccgatccgaa aaccgttgtc ggcccgctga tcaacgagcg ccaaatcgag aaagcgctgg 3566941 agatcattga gcaggcaaag acagacggca ttgagcttgc ggttgaagga aaacgcgtcg 3567001 gaaacgtgct gacgccgtac gtctttgtcg gtgcggacaa caacagcaaa attgcccaaa 3567061 cggagctgtt tgccccaatc gcaaccatta ttaaagctgg cagcgaccag gaagcgattg 3567121 acatggcaaa tgatactgaa tacggcctca gctctgcggt tttcacttct gatttagaaa 3567181 aaggcgaaaa gttcgccctg caaattgaca gcggcatgac ccatgtcaac gaccagtccg 3567241 tcaatgattc gccgaatatt gcctttggcg gaaacaaagc aagcggtgtc ggccgtttcg 3567301 gcaatccgtg ggtcgtcgag gaatttaccg tgacgaaatg gatttcgata cagaagcaat 3567361 accgcaaata tccgttctaa atgaaaaaat ccctctgttt caagtacaga gggatttttc 3567421 tttatttaga tatatccaca aacccttcgc caaacacatc gcgtacgtca tgtacgatca 3567481 caaacgcttt tttgtcgcag cttctaatga tttttttcag catagacagc tcctgtttgt 3567541 taatgacgat atacaaaatc tcttttgact ggcccgtata atttcccttc cctgataaaa 3567601 tcgtcacgcc ccgatccatc aaggtattta cctgctctgc aatctcactc ttattttctg 3567661 aaatgaccgt aatggctttt ttcgtattca aaccttcaat aatgaagtcc atcactttgg 3567721 taccgatata cagcatcacg atcgtaaaca tcattttttc tgcaccaata ataaaataag 3567781 agctaaatac tacgattaaa tcaaaaaaca agagtgcata gctgatattc cagtctaaat 3567841 atttattagc aattctggcc agaatcgcgg aaccggccgt cgtcccgccg acccggataa 3567901 tcatgccgat cccgactccg gcaaatacac ctgcgaaaat cgtattaatg atcaattcat 3567961 cagacggaat gctccaccca tgtgtcagat gaagaaaaag cgaatttgcc gcaaccgcaa 3568021 tgatcgtata aaccgttgtt tttccatcaa gaaacttgta gccgattaaa agcaaaaacg 3568081 catttaagat aaagttcgtg acaccaggag accattgaaa cagataatac aaaatcagcg 3568141 taatcccagt gactccgcct tccccaagat cattgggaat cgcaaataaa ttaaccgcaa 3568201 gcgcgaagaa aaaagcgcca atcacaagca taagtacatc cagcattctc tttttcatca 3568261 cgaaaacact ccttttcatt gttctgttct agcaaataaa aaaacccagg agaacgctct 3568321 cgaaaaagag cagaaactcc tgggctttta tcccaccgtg tcataacagc caagctgcta 3568381 tgtgttttct ctcggtcaca gtccaatttg cattgcggaa ccctagaaaa ccactgtttt 3568441 tatcatatcc ttttcacttt ccaatattag cattataagg gacggttcga attggttcaa 3568501 ggggtatttg cggagttttc atcagataag ctggaaaaaa atacgattta tctattaaaa 3568561 aagaacagat ataaccgata agaaaaaaag catatatttt acaagcgaat gtaactataa 3568621 atgataataa ttataagaaa ttcataattt tatattgact aagagaaata atataggcat 3568681 tatagtacat atgtttcgta cattttatta cataggagga aatataatgg caggaaaact 3568741 agtaccctgt aaagcttgcg gtcaagaaat tgcaaagggt gtaaaaaaat gtcctaactg 3568801 cggtaaggat caacgtaact tttttatgcg acataaaatc attacgttta ttctcgcagt 3568861 tgttgtcatc attattatcg gtaatatgat tggcggcgga ggcggctcag aagccacttc 3568921 caaaacatca agcagcagca aagcagaaac tgaaaaaaca tacaatatcg gtgataccgt 3568981 aaaaactgaa aaaactgaag tgacggttac gaaggtagag gacagagata ctgtcggtac 3569041 tcaatatgtt gaaaagaaag catctgaggg aggtacaatt gtagctgttc aatatacaat 3569101 taaaaacgta tctaaaaagc cgattagctc tttttcaatt ccaactgtta aattagttga 3569161 tgctgatggt acttcttatg attctgatat tgatgcttct gtaaactatg caactgagac 3569221 aaaagttgat aactctaaaa ttttgagtga tctaaatcct aatattaaag taacaggtgt 3569281 aaaagcattt gaagttgaca aggaagctta tgcaaaaggc acttggaaac taaaattcag 3569341 taatgatgtt attgtgaaaa tcaaataaca gctaacaagg gtgcctgttt aggcaccctt 3569401 gttctttaaa aaaggccttc tcaattgaga aggcctccat tcttattccg cactcttata 3569461 cccattcaca ttagaagact gccatctcca ggaatcagca cacatttcct caaggccgcg 3569521 tttcgcttcc cagcctagtt ctcgcttggc tttcgcagga tctgcaaagc atgtggcgat 3569581 gtctcccgga cggcggtccg caaaacggta tggaacctct ttccctgaca ctttttcaaa 3569641 ggctttgacc atttccagca cgctgtagcc tgtgcctgtt ccaaggttgt atgcatcggc 3569701 tcctgtagag ttcaatactt tttccagcgc cttgacgtgg ccttctgcga gatcaacgac 3569761 gtgaatataa tcgcgtacgc ctgtcccgtc ttttgtcgga tagtcatttc cgaatacgct 3569821 taattgctcg agcttcccga ctgctacctg tgccacatac ggcataaggt tatttgggat 3569881 tccgttcggg tcttcaccga tccgtccgct tggatgcgcg ccgaacgggt taaagtaacg 3569941 aagcagcgca acgctccact cattgtcggc tgtatgcaaa tcacgcaata tttgttcaag 3570001 catgagcttc gtctgcccat aaggatttgt cgcgcctaat ggaaagtctt ccgtaatcgg 3570061 cgatgtttcc ggaacgccgt atactgtcgc agatgaactg aatacgattt tcttgacgcc 3570121 gtatttctcc atggcctcgc ataaaataaa cgttcctgtc aaattgttat gataatattt 3570181 gaggggaatc gccacagatt cgccgactgc ttttaaccct gcaaaatgaa tcacagcttc 3570241 gatttcattt tcagcaaaaa cggaatctac cgcttcccgg tccaataaat ccgcttcgta 3570301 gaacgttaaa tcttttcctg taatctcctt gacacggttc agcgcttcag ctgaactgtt 3570361 ggacagatta tcaagaacaa caatctcgta gccgctgttc aatagttcaa cacatgtgtg 3570421 gctgccaatg taaccggcac cgccagtaac aagtattgcc atgatgtaaa ccctcctaaa 3570481 aaatgacctg ttttcattat atagtgttta gaaccggtcc acatccattt ttaagaagtt 3570541 taatcgttta ttaatagttt tttcatattt tttagcttaa acccttgcca gcaattcgat 3570601 agaggtttca gcaagaatgt gctctttcat ttcttgatag agctcattca agtaaaagcc 3570661 cggctgaaga ttcagctcag catctaaagc atagaccgtc aatgtatacg catgatcctt 3570721 gtcaggcggt gtcggcccgc aatactggtg aatcaccttt ggatcgttgc ttcccgcaag 3570781 cggtgaagca aagctgtttt gcccttgtat catcaagtcc tgtctttcct cactcgcatg 3570841 ttcaggaagc tctccgatgt aagccggaat attagccgct gtccagtgaa tccagctgaa 3570901 tccgcatacg ggaatggcgt catgatcgat gaaagtaagt gcgagcgtct ttgctccgga 3570961 cgggatgtca tcaaaatgaa ttggaaagga tacaaatggg tttccttctc tcttatattt 3571021 ttcatccgcg tattttgaat acttgtcatg taaatatgga tttgcttcta cgtatatgtt 3571081 catatgaatc cctctctcta ttttctcgtt ctataggtat actaaacgaa tcgatgtata 3571141 atcagtgata aacaaatacg catgtaaacg taacaatttg ttatggataa cttgcagtga 3571201 aggagatatt tcatggattt aaaatggctg caaaccttta ttgccgcagc ggaatcagag 3571261 agcttcaggg aggcggctga gcatctgtat ctcacacagc ctgccgtttc tcagcatatg 3571321 aggaaattgg aagatgaact ggacatgagg ttgtttttgc atagcggaag acgagtcgta 3571381 ctgactgacg aaggcaggct ctttttgcct tatgccaaag aaatgatcca tgtttaccaa 3571441 gctggaaagc agaaagtcag tcaatggaaa caggggtaca gccgatcact cacgctggcc 3571501 gtacacccct acattgcgtc ctatatcttg cctcgctttc tgccagccta tatccaaaaa 3571561 catccgcatg tcgagctttc aactcatgtg gctggatctg acgctattaa acaagcggtg 3571621 gaacacaatg aagctgatat tggtttgtcg cggaaagacc cgaacaccaa cactctttat 3571681 tatcagcata tatgcgaagg tacgctttgt ctggcggctc ctttccaaga aagcagaccg 3571741 gatgctgcat ccgtcttaac ccgctatcgg ctgctaacgc atgatcatcc gtcatatggg 3571801 gatgcctttt tagataacat ccgatcacat tacccgtatc ttcaaatgat ggctgtcggg 3571861 cagacggata cggctgtcca catgatgaaa gcgggaatgg gggcatcttt cctccctacc 3571921 tacattatca aacaggaaga agccgaaaaa aagctgatgg ctgtcagcac gcctgcacat 3571981 ctagaattgc ctgcgtccca aacgtttatg atgtggaaaa gaaacagcga agacattcag 3572041 cattttcacg ccatgttaca tgactttatg cagcgcgaac aagtatagag ctgaaaaatc 3572101 aatctgccgg ttgacgtttt tctttcctat tttcgctatg cttaatgcag aaaggatttg 3572161 atgacatggc gatgagccct tatattttta ttgtattgat tcttattatt ttatcgatgt 3572221 atcgagaaag aacggtaaag cccgggaagt tgctgatcat tccactgttg ctcttatggg 3572281 gcgtatctgc atcgtttcag ccggcgtatt ttcattccgt attacatgtg gcgatcagcg 3572341 gcattttatt actgatcggg ctggcctgcg ggtttggcat tgggaagatg gtaaatgtac 3572401 ggattcaccc ggaaaccgga aaggtcactt cacgcggctc acttgggagt gttatcctca 3572461 ttctagtgat actttctttg cgcatggccg cgagaacatg gctgcctgag agcaacgaga 3572521 tgtttattgc cattattcat tctatgttct tcgttcccct cggcaccatc acagcccgca 3572581 acatcatgct ttacaaagca tacagacgac tgaccgctgg caaagtatcc attcaataac 3572641 cgaaagaagg accagcatga acggacaaac tccggctcgg cactactaca agaagcttgt 3572701 gccgagcctt attctcattt tgaattgcat acaattttta tctcatccaa ctaaggctga 3572761 tcccattttg ttagcatttg tatttgcggt atacttagca ttcatttgga tcattcccta 3572821 tgtggcatcc actgctgtta gtttgagcat attcatcgga ctctggctcc tgaccgattt 3572881 cttttgggct gtttccggcc aagagcaggg tgccgcctat tttttgattg tatttttaat 3572941 gatatatgcc gcctttagac tcccttcacg gctatccttg atcttcacag catgtttaat 3573001 tggaggcaac atattactcc tatcctcaca agggggaagc ttgaatacca tcatcagcaa 3573061 catctcgatc atgctcggtc tgtacgtcct cttctcctcc atgcgtttca gacgagaagc 3573121 gagaagggag gctgaacgga atcatgctga attggcaaaa atgcatgtgc agctggagca 3573181 tgctcataaa gaactccaga aagcgcatgc agagctgcag gaggcttctg ttctttcatt 3573241 aaggtacgcg gtccttgagg aacgtacaag aattgcccgc gacattcatg acagcatcgg 3573301 tcacgagctg acttctgtga ttgttcagct tcaatccctt ccctatatcc ttaaaagcag 3573361 caaggaggat tcagaaaaag tcattcaaaa tgtactgagt gtcgccaggg agtgtcttca 3573421 agaagtgcgg tctgttgttc accaaatggg ccgtagtgaa tcgatggtgg ggcttaccgc 3573481 tttgcggggg ctcattcatc aagtggagga acggagcggc ttgcacgttt ctttagatac 3573541 tgccggactg tcagaagagt cttggcctcc aaacgtgagc gaaacgatct accgcatctt 3573601 gcaggaagcg ctgaccaata tcattcgtca cgctgacgct tctcatgcgg cggccgtcat 3573661 ttctaatgac aagtcccatc tctatgtcac aatcaccgac gacggacaat tcaccggcag 3573721 ccttacttat ggatttggcc tgacaggaat gaaagagcgc gcagaaaaag caggcggttc 3573781 ccttactttc agtgccgtac agccgagcgg cctgaaaatt gagctgtcat tgccgctcat 3573841 gacaacgaat aaggagcaaa aagatgaaca aagataaaat acgcgtagcg cttgccgatg 3573901 atcagccgct tgtgcgtgaa ggcttccgct acgtcatcaa cgcacagacg gatatgacgg 3573961 tttctggcga ggccggcgac ggtcacgata ttatagcact cgcaaaacaa acaaaacccg 3574021 atgtcatcct catggatgtc cagatgccgc gttgctcagg catcgaagcg gcgaaagaca 3574081 ttatgtccgc acttccaaat acaaagatag tcattttaac cacctttgac acggaagaat 3574141 acgtatttga aggcatccgt gcgggcgcag tcggctatct gctgaaggat acacttcctg 3574201 aggagttgat agatgcgatt cgcgctgcgg ccagaggcga ggcgattttc cgtacagtca 3574261 cagctgctaa aatcatcagt gagacatttc gggcgaaaca gcaaactcat gccgaagaac 3574321 tggcagagcc gttcaccaaa agagagcttg aggttcttca gcaaatggcc tacggactga 3574381 gaaatgagga tattgctgaa aagcttttcg tcagtgaaag cactgtgaaa acccacgtgc 3574441 accgcatcct gcaaaaatgc aatgcccaag accggacaca ggcagtcgtt tttgccattc 3574501 gaaacggtat tgtgcaatag aaatctctca tcccgccatg ctaaaataag acaaaggaga 3574561 tgattggaaa tgaaagaaga aatcattgaa cggtttacta catatgtaaa agtcgataca 3574621 cagtccgatg aatccgttga cacttgtcct tccacacccg gccaattgac attaggaaac 3574681 atgctagttg atgaattgaa gtccatcggc atgcaggatg cagccattga tgaaaacggc 3574741 tatgtcatgg caactcttcc ctccaatact gaaaaagacg tgccgacaat cggctttctc 3574801 gctcacgtcg acaccgctac agactttacc ggcaaaaatg tgaatccgca aatcatcgaa 3574861 agctatgatg gaaaagacat cgttcttaac gaacagctgc aggtcaccct gtcacctgat 3574921 caattccctg agctgtccgg ctataagggc catacactca tcaccacaga cggcaccacc 3574981 cttctcggcg cagacaataa ggccggtatc gctgaaatca tgacagccat ggattacctc 3575041 atcaaacacc ctgaaatcaa gcacggcaca atcagagtcg cctttacgcc tgatgaagaa 3575101 atcggaagag ggccgcacaa atttgatgtg aaacggttca atgcatcctt tgcctacacg 3575161 gttgacggcg ggccgctcgg cgagcttgaa tatgaaagct tcaatgccgc tgccgcaaaa 3575221 attacgatta aaggcaacaa cgtacatccc ggaacagcta aaggaaaaat gatcaactct 3575281 gcgaaaatcg cgatgaagct gaacagcctg ctgccggcag acgaagcgcc tgaatatacg 3575341 gaaggttatg aaggcttcta ccacctgctg tcgattcaag gagacgtaga ggaaacaaag 3575401 ctccactaca ttatcagaga ctttgacaaa gagaatttcc aaaacagaaa agaaacaatg 3575461 aagcgtgccg ttgaagaact tcaaaacgaa tacgggcaag accggattct gctggatatg 3575521 aacgaccaat actacaacat gagagagaaa attgaacctg tcatcgaaat cgtcaacatt 3575581 gccaagcaag cgatggaaaa cctcggcatc gaaccgaaga tttcccccat ccgcggcgga 3575641 accgacggat cacagctgtc ctacatgggg cttccgacgc caaacatctt tacaggcggg 3575701 gaaaacttcc acggcaaatt tgaatacatc tcagttgaca acatggtcaa agccgtaaat 3575761 gtcatcgttg agattgcaaa gcagtttgaa gcgcaagcat aacgccaaaa gccagtccaa 3575821 aaaaggactg gcttttttgt gtgaaaatga aacattttaa acacgtcctc cgtaaaacaa 3575881 gtatcaacaa atgaggagga aaaacaatga caaaacatgc aatcgctgcc aagagtctct 3575941 tgaaaaaatg gatcatttcc aggccgctta acatgaaaaa gaaatccagc ccatttcaaa 3576001 aaatcagaaa aatgttcaaa cgcttcttca aataaaacat caaatcccct aaatacaatc 3576061 cgtattcacc cgtaccgccc aaatgctccg taatttgggt tttttgtgtt caattccgca 3576121 aaatagggta taaaccaaac aagcaagaaa acagcaccca aaaacaggta attcgaatta 3576181 cgtaaactta ggttaaaagt tatataaagg aatttatttt atcgtcgata gtaactatag 3576241 aaccaatcat caacaagagc aaacagcgta attcaagact attttcaggt catcaggtaa 3576301 tactgtttta gagggacagt ttcttgttat ttattgattt agaatttttt gaatactttt 3576361 tggcatttta tccgtacaat agagagtacc aaaacttttt ttgggaggta tgtaatatga 3576421 tcctatttat tatcatcgca ttatgcggct atcttctttt ttctttcagc aaggacaatc 3576481 gccgcaaacc gcaaaagaca agccctctgc cagcagccgc acctcatcac aacaacctaa 3576541 tcgaccttga cgccatccgc caaaaacgcc ggatgcatct ttcctaattc tatatttcaa 3576601 acgaaaaggc tgctgaatca cgcagccttt taaaattgtt ttgatttaga gcctgaaacc 3576661 ttttcgccac ctatccgtaa tttcatacaa ggcaaaccca aaggagactt cagcaatgat 3576721 cgagttattt atgaaacaaa aaatgttctc atttaaagat gcatttcaca tttatgaccg 3576781 ggatgaacaa gaaacattca aggtggaggg gcgttttttc tcgttaggag actcattaca 3576841 aatgacagac tcatctggga aaacgctcgt ttccatagaa caaaaactaa tgtctttatt 3576901 gccgcgctat gagatttcaa ttggcgggaa aacagtttgt gaggtaacga agaaagtaac 3576961 gttttccaaa ccgaaatttg tgatttccgg gcttaactgg gaaatagatg gtgatttatg 3577021 gagggatgaa ttccaactga cggacgggga aaatgtccgg atgtcagtga gcaaaaagtg 3577081 gctcagttgg ggtgattcct atcacttgca gattgcatac gaggaagatg ttctgatttg 3577141 cactgccatc gctatcgtgc ttgatatggt tttatataac gatgaagatg aaagtatttt 3577201 ctaaaaagca ttgacaattg atccaaaagt aataatatta agataattga aatctgaata 3577261 tgaagttgta ccttatcaag agaggtggag ggactggccc tatgataccc ggcaaccgct 3577321 gtttcaaaca gaatggtgct aaatccttaa gaacattgcg ttcttgcaga tgaggcggag 3577381 atttgatcgt tcaagctctt ccttacacaa aggaagagct ttttacatgc ttaatatttc 3577441 agaaaagagg cgaataacat ggctcaacaa acgaatgttg caggacaaaa aacagaaaaa 3577501 caacgcaaag cacctttccg cgccgatcat gtcggcagct tgcttcgttc cgttccggta 3577561 aaggaagccc ggcaaaaaaa agcggctggt gagatgacag cggaacagct tcgtgatatc 3577621 gaaaatcaag agatcacccg catcgtggaa aaacaaaaag aaatcggtct cgatgtggta 3577681 acagacgggg aattccggcg ttcctggtgg cattatgact tcctggaagg gcttgacggt 3577741 gtggaaccgt tcatcccggc tgaggggatt cagttccata acacaaaaac gaaagcgcgc 3577801 agcatcaaag tgacgggaaa actcgatttt acgagccacc cagcgctcgg tgattatcaa 3577861 tttttacatg agattgccgg taacgcgacg ccaaaattga ccattcccag tccaaatatg 3577921 ctgttttttg gcgaaaaggc ggataaaggg atttatgacg atcaagagga atactttcat 3577981 gatatggccc aagcgtacaa aaaagcaatc aaagccttct atgatgctgg ctgccgttat 3578041 ctccagcttg atgatacgtc atggtctctc ttctttgagg acaaaggcag agaggttgtc 3578101 cgggcgctcg gcggtgatcc agaaacattg ccagccatat ttgccaaaac aattaacgat 3578161 gccgtcgcag accggcctga cgatttaacg atcacaatgc acatttgccg cggcaacttc 3578221 cgctcaacct gggcggcatc aggagggtac gacgctgtag cggaaacgat tttggacggc 3578281 ttaaaccttg acggcctttt cttggaatac gatgatgacc gctccggaaa ctttgatccg 3578341 ctccgttttg tgaagcgcaa ggatctgcaa attgtgctcg gcttgatcac atcgaaatac 3578401 ggcgagcttg aaaatcctga ggatgtgaaa cgccgtatca atgaagccgc gcgttttgtc 3578461 agcttggacc agctatgcct gagcccgcag tgcggtttcg cctctacaga agaaggcaac 3578521 cttctgacag aggagcagca atgggcaaag ctgcgccatg tcatcgacat tgccaacgat 3578581 gtgtggagat aatctatcat tgacagaaat agaaaatgtg tgaataatag atactatcag 3578641 aaaatttaat aaaaaggttt tccttatcaa gagaggtgga gggactggcc ctgcgatacc 3578701 cggcaaccgc tgtttaacag aatggtgcta aatcctttag agcaatgatt gctcttgaag 3578761 ataaggttga gattgtcacg caagctcttc cttatccaaa ggaagagctt ttttatattt 3578821 gaatggaaag aaggaatgga caacatgtca caacaaacaa cacccgcaga acaaaaatca 3578881 cttcaaagaa aaaaaccgcc gtttcgcgcg gatcaagtcg gaagcctgct aagatctgag 3578941 cccgtcaaaa aagcgcggct gcaaaaagcg gccggcgaaa tgaccgctga gcagcttcgc 3579001 caaattgaaa acgacgaaat catccgcatt gtggaaaaac agaaggaaac cggcctgaac 3579061 gtcgtgacag acggtgaatt ccgcagagca tggtggcact ttgatttcct ggaaaactta 3579121 gatggcgttg agccgtttac tcctgagcaa ggcattcaat tccataacgt acagacaaaa 3579181 gcacgcggca ttaaagtcac aggcgatatc gacttttcaa ctcacccaat gcttgaagat 3579241 tactcatttc tccatagcat tgccggtgac gcgacgccaa agatgacgat tccaagtccg 3579301 aatatgctgt ttttccgcgg aaaactggaa aaggatgaat acaaaaacga ttatcaactt 3579361 ttccagcacg atgtatccaa agcatataaa aaagcgattc aagcgtttta tgacagaggc 3579421 tgccgctacc tccagcttga tgatacagcg tgggccgttt tcttatcaga aaaaggctta 3579481 aaacaaatcg aagcgttcgg aacaacgcct gacgagcttc gccagctgtt tgcgaaatcc 3579541 attaacgacg cgattgcaga ccgcccggat gacttgacgg taaccatgca tatttgccgc 3579601 ggcaacttcc agtccacttg gacagcggaa ggcggctatg acgcagcagc cgaaaccatt 3579661 tttgacggct tgaatcttga cggacttttc ttagagtatg atgattcacg ctcaggcgga 3579721 tttgagccgc tccgttacgt aaaacggtct gatcttcagc ttgttcttgg cttagtgaca 3579781 tctaaattcg gtgagcttga aaatccggat gacgtgaaac gccgtatcga agaagcgtcc 3579841 cgttatgtaa gcttagacca gctttgcctc agccctcaat gcggattcgc ttcaactgag 3579901 gaaggcaaca agctgactga agaacagcaa tgggcgaagc tccgccatgt ggttgagatc 3579961 gctaatgatg tttggaaata agcaaagaaa aaaacacact tgattcccta gcggagcaag 3580021 tgtgtttttt atgtcattgt gcggtgtagc ccccatcaag gacgacagcc tgcccagtga 3580081 cgcccttcgc cttctcgctt gccaaaaaca cggcataatc cgcaatttcc ttgacggaaa 3580141 gcagtcgctt ttgcggcaca agcggaaaaa tgacttgttc aagtacagag tcgtaaggga 3580201 catttctagt tttcgataga tcgctaagct gattgcgtac aagctgggta tcgacataac 3580261 ccggacagag cgcattgact gttatgccgt ggggcgcgcc ttccagcgcc cctacttttg 3580321 tgagtccaat gacgccgtgc ttggcgctat tataagcgga tttccctgca aagcccacta 3580381 atccattaac agacgcaata ttaatgattc tgccaaactg ctgttttttc atgatcggaa 3580441 aaacatgctt cattgcaata aagggagccg tcagcatgac cttgatcagc tgttcaaagg 3580501 tgtctgtcgg aaactcttca atcggagcga cgtgctgaat accggcattg ttcaccagaa 3580561 tatccaagcg gccgtattgt ttttggatga cgttcaccgt atcagcaact tgcgcttcct 3580621 ttgtcacatc atacggaatg gccgccgcgt caaagccttc ttctgcaagc ttggaggctg 3580681 ctttttcaca tgcttccgga cggaggtctg aaacgatgac gctggcacct tcccgggcga 3580741 attctcttgc gatttcgaat ccgattccgc cggcagcccc tgtcaccaaa gcgacttgtt 3580801 ttctcatgtc aaacaccttc ccattaagaa ttgagtacag actggcttac agcgaaatca 3580861 gcttctgttt tttcataaac ctcttcaatt gtgacaccat cctgaagctc cgtcagtgtc 3580921 atgcggccgt tcacaaaatc aaatacagcc aaatccgtaa tcagcctgtg tacgactttc 3580981 tggcctgtca gcggaaggga gcatgttttt ttcacctttg attcaccatg cttattgacg 3581041 tgctccatga tgacaacgat tcgtttcgcc ccgttgacga gatccatggc gccgcccatc 3581101 ccttttacca ttttgcccgg gatcatccaa ttggccaaat ccccctgctc cgaaacctcc 3581161 attccgccga gaatagctaa atcgatatgc ccgcctctta tcatcgcgaa tgactcagcg 3581221 ctgtcaaaat aagaggcgcc tgtcacttca gtgatcgttt cctttcccgc attgatcaaa 3581281 tccgcgtctt ccgttccttc cagaggatag gggccaattc cgagcaagcc gttttccgac 3581341 tgaagcatga cgtgaacgcc atcgggtatc tcatttgcga caagcgtcgg cattccaatc 3581401 ccgagattca cattcatgcc gtccttgatt tcttgtacag cccgtttgac cattcgtttt 3581461 ctcgcttcct tcacttggcc tcaccctttc ccgatgcttg ctgaactgtt cgtttttcaa 3581521 tccgtttttc ttggctcgcg ccaagcacga catgctgtac gtaaattccc ggcgtatgga 3581581 tgtgatctgg atcgagctct cctgcttcca cgatttcttc cgcctcggca atcgtgatct 3581641 tgcctgccat ggcggcaatg ggattgaaat ttctcgccgt tttcctaaaa atcaaattgc 3581701 ccatggtgtc cgctttccac gctttgacga tcgccacatc gccggtaatg cctcgctcca 3581761 gcacataagt ccggccgccg aatgttttat gttcttttcc ctcggctatg gaggtgccga 3581821 cgcctgtcgc cgtataaaat cccggtatgc ctgcaccgcc tgcacgaatt ctctcagcga 3581881 gcgttccttg gggaacaagc tctacctcaa gctctccgct taaaaactgc cgctcaaaaa 3581941 ttttattttc accgacatag gaagcgatca ttttcttgat ttgcttgtta gccagaagca 3582001 aaccaagccc ccagtcatcg actccgcagt tattgctgac aacggttaaa tcctttactc 3582061 cctgatctct tatagacaaa atgagctgtt cagggatgcc gcacagccca aaccctcccg 3582121 cgatcagcgt atccccatca tgaatcagtt tcgcagcttc cttgcttgat gacagcactt 3582181 ttcccatatt gatgcccctt tcgttttctt ctacactaga ccagtcaggc tgtaaatcgc 3582241 gatcacagca aatacggcag ccgttttaat gagcgtgatc gcaaaaatat cgcgatagga 3582301 ttgccggtgg gtcaaacccg tcacggccag aagcgtgata acggcgccat tatgcggcag 3582361 tgtatccatc ccgcctgatg ccattgaaat gacccgatgc atcacctctg gcggaatatt 3582421 gtaagcctga atcgcctgta agtattgttc tgacatcgcg cttaacgcaa tgcccattcc 3582481 tcccgaagcc gagccggtga ttcccgccag cgcagttgtc gtaacggcgc catttacaag 3582541 cggatcggta aaagtatgtg aaattccgct gctcagctta tgaaaccccg gcagcgcggc 3582601 gataatgccg ccgaacccgt actcagcacc cgtattcata gatgccagca aggcgccgcc 3582661 aattccttca ttcagccctt ccttcaattg ggcaaacaca cttctccaat caaataatat 3582721 cgttgtgatg atgccaatca ctaaagcaat ctccaccgac caaatagcag ccgctgaaga 3582781 aatatcaagc ctgccgaact cctttaatcc tatggaagaa aaatcaaatc cattcggata 3582841 ccactttggc aggtaaatgg tgaaatattt attcactgca ccgacgagaa taagcgggac 3582901 aaaggcaagc gcgtgccgaa tcgggctttt gtccggttca gccgcggact caatcgattc 3582961 aggagcagga gcattctgcg aatcaaaacc gccatagcct tcgccagatg cctgcgcttt 3583021 cttccgcctt gattccaaat agagcatccc agctgccagc acaatcactg cgcccatcaa 3583081 acccagccaa ggggcggcat aaatgtctgt tttgaaaaac gacgtcggga tgacattttg 3583141 gatttgcggc gttcccggaa gtgcgtccat cgtaaacgta aaagctccta aagcaatcgt 3583201 acccgggatg aggcgttttg gtatgtttgc ttcttggaac atgtttttcg caaaaggata 3583261 tacagcaaat acgacaacaa acaggctgac accgctgtac gtcaagacag cacccatcag 3583321 cacaatggca agtatcgctc tttttgcccc gacaagccgg acaattgttt tcgcgattga 3583381 tgccgcaagc ccggccattt caacgacctt tccaaaaata gcaccgagca aaaacactgg 3583441 gaaatacagc ttaataaaac ccgccatctt ctccataaaa attgatgaaa aaaaaggaag 3583501 cacatggctt ggatctgtca gcagcaccgc gaataacgcg caaatcggcg caaacaatat 3583561 gacagaaaat ccccgatacg ccgtaaacat cagcaaacct aacgccaata gaatgatgat 3583621 cagttccaca cacacatccc ccgtttccgc gaactagaaa gcgtttacaa aaacctgtcc 3583681 gcatcggctg tttccgtccc ctttccatat gtacgagaag cgtgggccaa ctattccgat 3583741 taaaaaagga aagctccttt tttcggagct ttcctctacc attcatttca ttcctattag 3583801 gatatcaaca tcaaccgtaa tatcggctga tttcatctct ttcagcaggc tgactcgatc 3583861 tttcggcgcc gaccaggcaa gcggcgtcat cttgagaagc cagtggatcg cctgctggtc 3583921 aagcgtttta acatagcgca gcctgacagg acggctgtgt gctgcatttg ctgtaaaacg 3583981 ctcaactgct gccgtattgg aatacgtgcg ccttggtgaa tcagtatata aaaattgcct 3584041 taattctatt aaatagtcgc ttcgcggcac tacttttatg agcatgccat cattcttcag 3584101 cagtctatga aactctgcat aattggacgg cgaaaaaata gacagaacaa catcaaattg 3584161 gcgatcatga aaaggagcac gcgccacatc ggcaaccgcc cacatcagat ctttgaatgc 3584221 cttagaagct tttaagatcc cgtccttcga aagatctatg ccggttccta tcgctgcttt 3584281 ccctgcataa tcaaacccgc aaagcgcatt caaatgagaa ccctcaccgc aaccgctgtc 3584341 caagatggtg aatgcctcat gaccagattt gggatgactg atgagctctg caatcgcatc 3584401 atggagcggg tcaaaaaaac cacattctcc aatcagcctg ctcctcgctt caaaaagctc 3584461 ggcaccgtaa ctggttttga ccggcttcgt cagaaagttc acgtagccgt gccgagatag 3584521 atcaaatgta tgtcctcgtt ctgtacaaat caagcttttc cctgatgccg catccataga 3584581 agaatcgcag agcgggcatc gaaacatgct gaaatcaact gttcgcttca tgataaaaaa 3584641 caccccattc attcattttt agataaatga aaaaggcata gacaaataaa cctaggccta 3584701 tctcaaaaat tggccaggtc tggcagtttg tctacacctg tcattatcta taacgaatga 3584761 attggataat catgaaaaaa actccctttc tgctgtatgg gtttccccgt ttccatcata 3584821 caacaaatat ccaggagctg gaaccttata gtgaagaaaa atcagtactg acatgctggt 3584881 atcccgccaa catcatatca gcatagcaat ccagcatgtt tttcctttat tttctcattt 3584941 tagaatataa attttattat tgtgaaaata gttaaaaagg ttgattttca aaaagtgaaa 3585001 ggataaaata ctgctatcat cttagaaaaa gacattcttg tatatgatca gtaatatggt 3585061 ctgattgttt ctacctagta accgtaaaaa actagactac aagaaagttt gaataaattt 3585121 gaacgagttg aaaaggacaa gttcttttct gtttgctctt atttttcaca ctttctgcac 3585181 ttccagaatt tgtgaaggat aagagctttt tttgtttcca taataaccct cataggagtt 3585241 gctatcatgt actttttact aaaccttgtc ggtctcattg tgattatggc agttgtattc 3585301 ctatgttctc cgcagaaaaa gaaaatcaag tggcgcccga tcattacgtt aattgttctg 3585361 gaattgctga ttacttggtt tatgctggga acaaaagtcg gaagctgggc catcggtaaa 3585421 atcggtgatt tcttcacttg gctgattgct tgcgccagtg acggtatcgc gtttgccttt 3585481 ccgtcagtga tggcgaatga aacagtagac tttttcttta gtgcgcttct tccaattatc 3585541 tttatcgtca cattctttga tattttaacg tatttcggca ttttgccttg gctgattgat 3585601 aaaatcggat gggtgatttc aaaggcttcc cgcttgccga aattagaaag ctttttctct 3585661 attcaaatga tgttccttgg aaataccgaa gcacttgcgg tcatccgcca gcagcttacg 3585721 gttttaagca acaaccgcct gctcacattc ggtttaatga gcatgagcag catcagcggc 3585781 tccattatcg gatcttatct ttcaatggtg cctgcgacat acgtgtttac agccattcct 3585841 ttgaactgct taaacgcgct gattatcgca aacctgctga atcctgttca cgtgccggag 3585901 gatgaagata tcatctatac accgcctaaa gaagagaaga aagacttttt ctctacgatt 3585961 tctaacagta tgcttgtcgg catgaacatg gttatcgtta ttttggcaat ggtgatcgga 3586021 tatgtcgcat taacgtcagc agttaatggc attcttggcg ttttcgtaca tggcctgacc 3586081 atccagacaa tttttgctta tctgttcagt ccgttcgcat tcctgcttgg actgccagtg 3586141 cacgatgcga tgtatgttgc tcagctgatg ggcatgaaat tagcaacgaa cgagtttgtt 3586201 gcgatgcttg acttgaaaaa caatctcaaa tcccttccgc ctcacaccgt tgcggtggcg 3586261 acgacattcc tgacgtcctt tgcaaacttc agtactgtcg gcatgattta cggcacgtac 3586321 aattcgatcc ttgacggaga aaagtcaacg gtcatcggga gaaacgtgtg gaaactgctc 3586381 gtcagcggaa ttgcggtatc tttattaagt gctgcgattg tcggcctgtt tgtgtggtag 3586441 aaacattgag ccatatccct tttcggatat ggctcttttc attattgata aatagaggct 3586501 ggcacctgca catcccggat tcccgctgca taaggcccca agtcatactg gccgaagacg 3586561 atggcgatcc cgtttgccgt aaagtaaaac attgtgtctc tgtttagggt tatatcctct 3586621 ttctttacat cagagaaaaa cagcacatcg tgttttttga tatagctata taggtaatct 3586681 ctcgttttgc tgacttttgt tttggtgttc agaatctgat ccagcgtcac ccgcttttgt 3586741 gctttcaagt catagttgaa ggactggaca gacgttagac cgtgggcgcc ccctgaatag 3586801 atataattga gtgtttgaat gctgagcttg cctgccgcat tgtatttgac gctgaaggat 3586861 gtttgatatt cccgttttaa agccctgctg ttcgcctgct tttttgtttt tcaggtattc 3586921 ctgatacgat tgttcatgta ggctttcagc tcttgattga ttttcttttc aaacgcggca 3586981 ttcccgacgt gatgcacttg tggatacgtt aactccttga tctttttgta cgtatgggtg 3587041 ctgacagtcg gtgttttcgc ttgaactgct tttaaagatg gggccgcata tgcaaataca 3587101 gaaaaaagca agactgcaat gcccgcggct ttcagcatgt tattccattt catacaatct 3587161 actcctttga tgtcgttgtt tatcattccc ttatttaagc aatacacact tttatagact 3587221 gattaaatcg aaagaagttt ctaggtctaa cagcatgatt tttccaataa aaaaagagac 3587281 acaggatgtc tcttttttta ctgtttgcgc ccagaaatcg cttcatgaag ggcttgtgcc 3587341 aaatctgtat ttccgaacat ctctaatacc gcaatgacag tctggtccgg aatgtgctct 3587401 gcttcgtgtt ttggcacgac cagatcgtcc atggtttttt tcaagctttc attcagcttt 3587461 tgctgcggat acgctttggc gtacagctcc atcggatcaa gatcatggtt cacgcaccac 3587521 tgggcaaaca ccaaaatcat catattttca tcgcgttcgt aagcttcagt gagctgtttt 3587581 tcgttcattt gtcatgctcc ttatgaaaag tatcttcctt aaagatacag gagccgatca 3587641 aattcgtcta tcccaatggc gatgagcagc aaccgcatcg ataaatgcct tgctgaaagc 3587701 ggtgtagtca ggttcatctt tagccgttac gatgcctagc ccctctgttg tcccgacaga 3587761 ggattgaaga aggtcaattc cttcatttgc cgcaccgatc gccttgtagt gattgtaagc 3587821 ttctctgata aacgccatcg cttgtttgtt gtcttttaac tccagtcctc ctgcggcata 3587881 gacggcatca tacagaacag aatcaaccgt caggaacgtg ccgctggcct caagctgctg 3587941 tccgctgccg cttgtcatat accccagatt ttgactgatg atatccactg tgattccttc 3588001 ttgctttaag gcttccagta ctgtttgcag ctctttttca tgaaatccgt ttccggcgag 3588061 tacagcgact tttcttgttg acgcggtttt cactgtacgg gcttggctta acgcaggcga 3588121 agtaagaatt tctttagatg ctttacgctt cgcgggcgcc gccacgccta ctcctttggc 3588181 gatttcttct gctaaatctg catcgacatt gctgaagaca tcaacgacct gccgctgtac 3588241 gtctttgctt ttgaccttcc cgacctcgaa gcagaaagca gaaatgatgt gctgtttctc 3588301 cacaggagac atgctgttcc agaaaagctt cgcctgtgag taataatcgt tgaagctgtc 3588361 gcttcgctgg cggatttttt tgccctcgac tttttcctga tagtggacgt agccgccttc 3588421 ttcagctgtc gcaggcgacg gatcattgtt ttgcagtgag tttttatgat aagcgacagg 3588481 tcccttattg atcgtcatcc ggtgatagcc gtcgtattgg ttgttatgga atggacagac 3588541 cggccggtta atcggaatct catggaagtt cgggccgcca agacggatga gctgtgtatc 3588601 cgtataagag aaaagccgcc cctgcaatag cgggtcattg gtaaaatcga tgcccggcac 3588661 gacatttccc gggtggaatg cgacttgttc tgtttccgca aacacattat cctgattgcg 3588721 gttcagcgtc atttttccaa tgatcttcac cggcacaagc tcttccggcc acagcttagt 3588781 tgggtcaaga atatcaaaat caaacttgaa ttcatcttcc tcatcaatca tctgcacgcc 3588841 gagctcgtat tcaaccttgc cgccgttttc aattgtttcc cacaggtcac ggcggtggaa 3588901 atctggatct ttcccggcaa ttttttgcgc ttcatcccat acgagagaat gcacgccgag 3588961 caccggcttc cagtgaaatt tcacgaaacg tgcctttcct tgttcattga caaaacggaa 3589021 cgtgtgaacg ccgaagcctt ccatcattct gtagctgcgc gggatgcctc tgtcagacat 3589081 cgtccacatc accatgtggg cagactcagg gttattggcg acaaaatccc aaaatgtatc 3589141 gtgagcagtc gcagcctgag gcatttcatt gtgtggctca ggcttaaacg cgtgaaccaa 3589201 atccggaaat ttgattgcgt cctgaatgaa aaacaccgga atgttatttc ccacaaggtc 3589261 atagtttcct tcttcagtat aaaattttgt cgcaaagcct ctggcatccc gcaccgtgtc 3589321 tgcggagcct ttagaacccg caaccgtaga aaaacggaca aataccggtg tcttcaccga 3589381 agggtcctga agaaatttgg cccgtgtgta ttccgtcatt ggttcgtaaa cctgaaaaaa 3589441 gccatgcacg ccaaatccgc gcgcatgcac aacgcgctcc ggaatcctct catggtcaaa 3589501 gtgcgtcatt ttctcccgga aatgaaaatc ctccatcagc gtcgggccgc gaaccccggc 3589561 ttttaacgag tgctcatcct ctgacactcg caagccttgg tttgtcgtca ttttcttccc 3589621 gctgttatcg gtcctgtact gctcaagctg ctcgtccttt gagtgttcat ttacacgttt 3589681 gttttggtca tcactcatgt ctgctccccc tttttaaaac gaaacattct acagcacatt 3589741 tacccgtggc gttcttcata taaactgcta atccgctcat taggattttt ggtctacata 3589801 taaatatgcg gtcatacaca tttgaaataa gccttcttca cagaaagaaa ggatggaagc 3589861 gcttaccaaa aaagctgttg aataggggag gtcatatcat gcttgccata ctcggttttg 3589921 tgatgatgat tgtctttatg taccttatta tgtctaaccg gctttccgct cttattgctt 3589981 tgattgtcgt tcctattgtg tttgccctga tcagcggatt tggcaaagat ctcggcgaga 3590041 tgatgattca gggcgttaca gacctcgccc ctaccggtat catgctgtta ttcgccatcc 3590101 tgtatttcgg cattatgatt gactcaggcc tgtttgatcc tctcattgcc aaaatcttat 3590161 cgtttgtcaa aggagatccg ttaaaaatcg ccgtaggcac agcggttctg accatgacca 3590221 tttcgctgga cggagatggg acaacaacct atatgattac cattgcagcg atgctgcctc 3590281 tctacaaacg gctcggcatg aaccgtttgg tgttagcggg aatagcgatg cttggttcgg 3590341 gggttatgaa tattatcccg tggggcgggc cgactgcgag ggttttggct tccttaaaat 3590401 tggacacgtc agaggtcttt acaccgctga ttcccgctat gatcgccggc attctctggg 3590461 tgatcgccgt tgcttatatc ctcggaaaga aagagcggaa gcggctcggc gtcatttcga 3590521 ttgatcacgc accgtcttcc gacccggagg ccgcaccgct caagcgtccc gctcttcaat 3590581 ggtttaacct gctgctgact gtcgctctga tggccgcact gatcaccagc ctgctgccgc 3590641 tccctgttct ttttatgact gcgttcgccg ttgccttgat ggttaactat ccaaatgtca 3590701 aagagcagca gaaacgaatc tcggcgcatg cgggtaatgc gttaaacgtt gtctcaatgg 3590761 tgtttgctgc gggcatattc acaggcattc tctccggcac aaaaatggtg gatgccatgg 3590821 cgcattctct cgtttcactc atccctgatg ccatgggccc gcacctgccg ttgatcactg 3590881 cgatcgtcag catgcccttc acctttttca tgtcgaatga cgccttttac ttcggtgtcc 3590941 ttcccatcat cgccgaagcc gcttccgctt acggaataga cgccgctgaa atcgggaggg 3591001 cctccttgct ggggcagcct gtgcatctgc tcagcccgct tgtgccttcc acctatctat 3591061 tggtaggaat ggcaggcgtc agctttggcg accatcaaaa attcactatt aaatgggccg 3591121 tgggaacaac gattgtgatg accattgcgg cgcttttgat tgggattatt tctttctaaa 3591181 tgtatgagct tgatcgtagc attgagtgag tacgtgattt acagagggga gaagatcaaa 3591241 taggatatta tgagtgaata gaagattcat gccaacaact tctcattaca atcataagag 3591301 cctgctatat tgcagcaggc tctttcacat ttggcattat ttttttgtat agcgcaccca 3591361 gtcataatga gcgtatagcg gatttacacc attgtaggag ccaagccatt catcgacacc 3591421 cgtgccattc cacaagttca tcatgatctt tccaggtgtt gtcggaattt ggtttgttgc 3591481 agtatgtttt aattgcccgt cgacatacca tttaatagag tttggctgcc aatcgaatgc 3591541 atacgtatga taggcattgg ctgcatcaaa cccgagatca acaatcttct catggtttcc 3591601 tgcaccattt gtataatagt taaattgaac cttcgttgtg tcttttccta aaaattcgat 3591661 atcaatctca tcccaaggag ttccatctgt tggacctgtg taagtgaaga acgatgaaac 3591721 gatccctgtg tttttagctg gtttcattct gacttcataa agtccatagc catatgtttg 3591781 aacagaacgg ttttccccgc agtcaaactt gttataagct gggcttgtta gcgctaaacg 3591841 catttcaccc aatgacgtca ttgatacgtt attagcccgc cacgtgcagt tgaacatatt 3591901 tccattcgaa taaccatctg ctttttgcca aaaaccggag ttatagccgt taaaagggtc 3591961 aaaaaacgat ccacctgttt gagctgaggc agtagcagtg actgcaaaca aactcataaa 3592021 caatccagtg acaagaagca gcaacactcg tttcagataa ggcatattgg cattcccctt 3592081 tcattgaaag cgttttctat gttgatctta catgattctt ttaaaaggga acatcggtca 3592141 aaataatgat aatatcgaat cttactaact tgaatcctgt aactatcatc atcttccctc 3592201 tgaaaaaaat aaaaacctaa attaccatca gcacagacag agatgatccg cactcattgc 3592261 aatttaggtt ttgcctgctt tatcagtaac aatcctacca ttttcatatg tgaatgtaag 3592321 aaaaagtgaa cacaaggaaa cacaaatgtc agcgctctca ttatgcttgt ttaactaccc 3592381 tttctatgtg aatggttaaa tacagcagct cgtcacttgt gagcttgtgc tcatactccc 3592441 gctcaatgta ggtttggatt ttcttcgtgc attcatacgc gcgatgatac ttttctttca 3592501 ctgtatccag caaaaaatcg tcctggcttt ccatgtgagt gccgttaaat agacgctgcg 3592561 cgaaaaactt taagtgggtg acgaaccgat aatagtgaag cgattcttcg ttgaattcaa 3592621 tcttaaaatg gtattttaca atactcaaaa tctcttgcat gacttttgta atgttgataa 3592681 tattgggcat ctcttcattc agctcggcat ttacaatatg cagagcaata aagcctgctt 3592741 catcctctgg cagagacaca ccagtcttgt tttttaccat aaccaacgct tctttgccga 3592801 tcgcaaattc gtctttgtag agccgttttg tttcccacag caaggcgttt ttgatatcaa 3592861 gccctttctg gttgcgctgg atggcaaagt taatatggtc ggtcagcgac acatagatgc 3592921 tgtcgttgag ctttttgccg agctgtaatt ttgcgtagct gataatctct tcggatactt 3592981 ccatacactc gatcggtata tcatacaaaa gggttttgaa cttttctgat acatccttgt 3593041 tatcgagcgt gaacactttc tcaatgcggg cttcatcgac atcatcgccg gactttttct 3593101 gaaacgcgag ccccctgccc atgacgacca attctttccc ctgttcattg accacgctga 3593161 tcacattatt gttgatcacc ttcgcaattt tcatggcatg tccctccaaa tctactaaga 3593221 acagactata tcttgattgt acattctttt tgtactaggt caatatcatc agggaaagac 3593281 ggaagctggt cagtacaatt cactccgtac ctgctgcccg ggctgttttt gaagcagcgc 3593341 ctccagatgg cgttcaaatg atgccttgtc agctttctgc tttttgacaa tgctgttcat 3593401 gattttaatg ctttcagcac tgtattgtgt atattgtttt ttcagctgat ccagctgctg 3593461 tcttgtcttc ttcgcgtttt tcggtgtgac ttggttgatg agtttgatca tactgtctgc 3593521 ggtctcaaaa aaaccggctc tattttctgt cagctgctga atttcgatgc ggctcatatc 3593581 ttgattacgc gttttttgaa gcaaggcaac cgcctcgctg ttttgttttt tgagcgattt 3593641 gttctcaagc ttaatcgatt cgagattctc cttcgcaatg tctgcttctt cttcagtcat 3593701 gctgattcgc acgaagtatt ctggattgcc gattccataa tcaaatgctt cgctcacttg 3593761 tatcatggaa ctgaacacaa tggccagctg cctgtcgctt gcgagggctt ggaaatcctg 3593821 ctttttctta ctgctcatcg gtttggctgc ggtttgtttt actgtctttt gatcacagtc 3593881 tgcgaacatc tgagcctcac cttcactttc gcatgcgctc atcacaagaa ctgtgaccag 3593941 caggcttata cacaagccta ttcgcctcat gctctgtctc ctctctgctg aatcccttct 3594001 ggaaaatacc ataaaatata gttaaatggt accagatgca cctaacccca gcaataaatc 3594061 aaaagtatga tttgaagcga aaaaacataa atattttgta aaaattgacg tgcattccat 3594121 tcttttcagg cccatttctc gtacaataga agtatcgtta ccggagaggg gctctgatga 3594181 tgaaacgttt tacgaaacaa gaaaacagct gggtgttata tgactgggca aattcagctt 3594241 actcaattgt cgtgaccacc gcggtatttc cgttatttta taaatcagca gctgcggaaa 3594301 gcggtgtcag cgccgctcaa tcgactgcct atctgggcta taccattgcg atttcaacgt 3594361 ttattcttgc gatgctcggc cctattttag gcacaatcgc cgactatgaa gggtgcaaga 3594421 aaaagttctt cggtttcttt gtgtcagccg gtgtcgccag caccgcgatg ctcgccttta 3594481 tccctagtga acattggctg ctattgttgc tgttttatac ggtatcggct atcggttttt 3594541 ccggcgccaa tgtgttttat gatgcctttc tcgtggacgt cacgcctgag aagcggatga 3594601 atctcgtctc ggcacggggt tttggcttag gatacattgg aagcacgatt ccatttatca 3594661 tcagtattgc tgtcatcctg ctcgcacaag cagagactat tccagtgtct gtatcggccg 3594721 caagccagct gtccttcttc ataacggctg cctggtgggg gctgttcacc atcccaatga 3594781 ttaaacatgt ccatcaacgc tattacatca aaaaagaacc tcatattgtc atcaacagct 3594841 ttaagcggct cggccaaacg atgaaacgga tcaggcaata ccgggcactt ttcctcttct 3594901 tgctcgctta tttcttttat atcgacggag tcggcacgat tattacgatg tcgacatcct 3594961 atggatcaga tttagggatc ggctcctcaa gccttctgat catcctattt gtcacccagg 3595021 tagtcgccgc gccgttttcg attatatacg gaaaactggc agaacgcttc acggggaaga 3595081 ccatgctgta cgtcgggatc gtcatttata tgatcgtctg cgtgtatgcc tattttatgg 3595141 agacaacgct tgatttctgg atactggcta tgcttgtcgc cacctcgcaa ggcggtattc 3595201 aagccctaag ccgttcctat ttcgccaagc ttgtgccaaa gcgccacgcc aatgaattct 3595261 ttggcttcta caacattttt ggaaaattcg cctcaattat ggggccgctg ctcattgccg 3595321 ttaccgccca gctgaccggt aaatcctcga ctgcggtgtt cagcctgatc attttgtttg 3595381 tgattggtat tgtgattctt gcctttgttc ccgaggaaac cagcacagat gtcagccagc 3595441 agcaaaatga cctgcccctt taactgggag caggtcattc atcatttatt cgctttattc 3595501 accttcagct gtttcccttt gacggttgtg ttcttcatca ctttgagaac atgagggcct 3595561 ttaccattta aaatctcaac gtatgaggcg ttatccatga tcgtgatgat gccgatgtcg 3595621 tcagctgaca caccgtcaat tttggcaatc gttcctacaa aatcaacggc tctgattttc 3595681 tttttctttc cgccgttaaa atacagcttc ataatgtctt tattcagctc ttcgcttttg 3595741 tcctttttgc tttccggacg gtcattcagt ttagctagaa attctggttt cttccttgcc 3595801 acttcctctt gagaaggtgc ttctattttt tggatttcaa atccgatata ttcttcaatg 3595861 tcggctaaaa accgtttttc gaaggccgtg acaaacgaaa tggcctttcc tttgttccct 3595921 gcgcgtcccg ttcggcccgt gcggtggaca tagctttctt tttcaagcgg cagatcatag 3595981 ttgatgacaa gggagatatt ttcaatatca atcccgcgcg cggcgacatc cgtcgccact 3596041 aagtaacggt actcgccacg tttaaattca ttcatgacgt cgaatcggtc ttcctgaatc 3596101 attccgccgt gaattttatc gcatggatat cccaagtcat ccaattcatc ggtcagctga 3596161 ttgacgtgct ccttcgttcg gcagaaaatg atgcagctgt cgggattctc cgtcatcagc 3596221 acatctttca gcaatgaaaa cttattctct tctcttactt gaatcaccgc atgttcaata 3596281 tttcttgtgg ttaggccggc cgctttgacc tcgatatgct cggggttttg catatattga 3596341 cggctcagct tctcgatatc ctgcggaagc gtcgctgaaa acagcatcgt cgtacgctca 3596401 gtcggcagat gcttgataat cgcctccacc tgctcaatga agcccatatt cagcatctca 3596461 tccgcttcat caatgaccaa ataagagaga cgatccaacg gcagcgtgcc tttttcgata 3596521 tgatccagaa cacgtcccgg cgtgccgaca acaatgtggc ttttttgctt aagctcagct 3596581 ttttgtttat caaaggagga ttttccaaat acggctgtcg ctttgatccg tttaaatcgt 3596641 ccgatgttcg tgatatcttc ctttacttgc accgcaagct cacgggtcgg tgttaaaata 3596701 agcgcctgcg gcttgttttc atcccaattc gccagctcac agagaggaat cccgaacgaa 3596761 gccgttttcc cgcttcctgt ctgtgatttg acgacaagat cctttcgttc aagggcagcg 3596821 gggatcacac tctgctgcac cttggtcggt tctgtatatc ccagtccttc caatgctcgt 3596881 aaaatgtcat gactgatttg atagttttta aaatgactca tgtataaact cctgtctctt 3596941 gcagatgttc tcattatact ctaattgacc aaggcatatg tgttttgtcg aaaaatgatg 3597001 tattaaaagc cagcgattcc ctggcgtttt agctcctgaa cagccaatcg cgccagtgcg 3597061 tcggcccccg cgcgattcgg gtgcagcgta tctccatcca tataaagccc gagtgttctt 3597121 tccggaccga tcgatgtaaa gtatgccgag ctgaggacat ttaagtcaat gagatatgtt 3597181 ttttcctctt cggccaaagc taaaatagag gccctgtacc atctgtttac agacgaatgg 3597241 atgccttcag aagtaaaatc ggttgcccgg ccctgaggcg ttgataggat gacgtccgct 3597301 cctttcgctt ttacctgacg aatcatatca cgcatcacct ctttaaactc cgcttcagat 3597361 tctttatgct tcggatttgt gtcattaatg ccaagctgca acataaaata atctccgggt 3597421 ttaatatact tcagaatcgc ctcaagctgt ccatcatttc tgaaccctct cgcgatctgc 3597481 ccgccagacg ccatgtttct cacttgaaag gtgtgtttat cgatatagtg aggcagcatc 3597541 tgcccccagc ccgcctgctt gctgctgttg agcggataat aattgcacac cgtcgagtcg 3597601 ccgccgacat aaatggttcg attcgttacc ggctgatcag acaatttctt tattttcaag 3597661 gcgctgagcg taaaagcggt gcctgccttt ccctctgtca ccagcagatt cagctgcccg 3597721 tcggtgacgg gaatttggaa cgtatcctcc gcgccatccc ctgtcatatt gatgacctga 3597781 aacacgccct ccgctgccac actggccctt gccgtattgc caagcgtcac cttcacctca 3597841 taaaggccat tcgggagatc aacattaaac gtgttattgc ttttcgtccc atacgctaaa 3597901 aactgaaccg catcactctt cacaccagcc ccggatgccg ccacatccct catattctcc 3597961 ggtgtttgaa aaccgtagcc ctttgaccgg tcataccgat cagacgccct gacaccaata 3598021 taaccaggct ccatcgaacc gcttccaaag tcaaactgat acaccttcgg ctccgccgcc 3598081 ttcacattct caatcccgcc aaaacacagc atcagcatca tcacaaaaac cgctgccatc 3598141 cattttttca tcaagactcc ccctctatga aaacgaatac attaatgcat actcggtgat 3598201 tgtttcttta tgatgactga attaagaaaa aaattgcgtt gaggaataaa aatgagggga 3598261 gagtctcaag aaggggaaaa tcagtgtgac ttcttgtcac acttgatcac atcccaacct 3598321 ccgcaataga agcttatttg gttttcttcg tcatacacat aataacggag tctttcccat 3598381 tgatcgtcag tcggtacaat ctccaatgca accgaatcga tggattcaag gtcatccagc 3598441 tttgatgcac taatgttttc aaaccgcaat tgaatgtcac aggtttgagc agatcgtttt 3598501 cattcaaaca caggaatatg aatataacga tcatcttctt tcatatagaa agaaaactcg 3598561 tttaatgtaa atggacctgt atcctcatca gaaagatgct gtttcaattt ctcgtattgt 3598621 gtgatattca aatgaattcc ctctatttat atgattcacc gccaatcata taaatgtcca 3598681 cagcatcgta ttcaaaccat atgatccgtt cgcctgagtc cgttaggcat tggagcttcc 3598741 cttctgaaaa atagctttta tccggttgag gatcagtgat cagaaaaaca tcatcattga 3598801 tggaagctag cagaaagaga aaatctgcaa tatcccggtc tgcttcctgt aatatggatt 3598861 ggaaatggaa ttcccttttg gccagcttcg tcaccttgta agcatgacct tcaaaatact 3598921 cggacaggtc ttctataaat gaaccagtcg ttattacctg tatcatgatt cgatcgtagg 3598981 caagccctgc ccaaaaacga taaaacgact ctgcatcttc aagttcgcat gccataacgg 3599041 tttggtcagg cttaagctcg atcatgtcca aattgccaat actgcttata gaggttattt 3599101 ccataaaatc ttccccttat cagttggata gcgcaacgca aatctcttgt ctgacttgtt 3599161 catacaagag aatgtgatga tacagatcct tatcgttttt gatcatatcc ggaagtatgt 3599221 caggatacag ctcaaaaaag cttttctcca acgaacgccg ctgatgccgg ggtatccttt 3599281 tattcgccag cacataatcc aaactgccag caacaagcat aaaaaactca tagatttccg 3599341 cttcaaagcc gtacaattca tcagggtact gcttttcttc aagctctcgc tgtctttttc 3599401 tcagtttttg aagcacgttg atcctctccc ttccgcaata atctcattta tttcgaaaca 3599461 gaataggcgg atcattatct atcgcctcca acagctcttc accaaacaca gtgattgcac 3599521 atttccacgg gtctcccaaa agtccccagg agaagtcctg atgaaaaaag aaataatagt 3599581 ctccatttgg aaatacggga acaggccatt cgccaaattc atccttaggc attgcctgat 3599641 gaggactaaa ggtatatccg tcatgctgcc aatctagtgc gtacattaca tcgttctttc 3599701 cagtacctaa ttgaaatgct tttaaaatag aagtctctaa atcacttagc actccgctca 3599761 catcattatg accagcttta ctgctcatcg cgcttgagat atcaaacact cgatatggat 3599821 caggcgggat gatgtgatga catctgcttc cgggcttcca ttttatgatc ttgttcactt 3599881 ctgaccagat gcggtcttgt tttgtctgac ttaaagcgcg ccaattcatc ataatctcat 3599941 ccctacacct tattggatat cctgcttata aacaccagaa gaggccactg cgtaaacagc 3600001 gtaacttgtc agtttcagct gttgaacatc taggccttca ccgttcgaat cacagcatgt 3600061 tatctcttcc atctcttgac tcacatcggc agaaatcaaa taaagagacg acttaaggtc 3600121 tgcactgtaa caattgaacg tcccaaccaa aaaaccttct tcggatatcg cgagctgatc 3600181 aaatgcttct gagtccggct ctttatccga cagaatccac acccgtctca cgaccgtttc 3600241 atcaaatgcg gcaatgactg catctccgta atacagcata taaatcaagc cgtttttttc 3600301 tgcaagtcca taacaatcat ctacagcagg cgcatccatt tcttcaagct ttctatcaat 3600361 gtgtatttcc ttctgctgac catctaacgt aaaacaccac acactatggc cgttgggatt 3600421 ctcatcatga taaatccctt catcacataa accgacccaa agctgttgtt tctaatccaa 3600481 aagacagcag gaaacccctg aaggcaagtg aaaaacactt ttcacccttc cctcttctga 3600541 aaaaaccttt accttcggct cgtacgattc gtaataaacg aagacatagc catctgcaca 3600601 ttgttgaaag agcagaatat cactgtatga aatctgctct ttcactctaa aatcccgaac 3600661 atcaccggaa ggatcataga ttgtaatggt gataccacct ttcaaccctt ttccaatgta 3600721 gacacgcccc tgtggatcag catggaaaaa acaatcttgg gtgttctcgt tgatgatttt 3600781 attcaatttt aattttttca ttggttatgc tcctaggttc gaaatgaaat gataagaata 3600841 aaccatttat tagctattag taacggacaa cctagtttca ttaatcgttt tgggataaat 3600901 ctactttcca attcagcctt aaatcattta gtgtttaatt ggtatgcata aaacgattga 3600961 tcatcaaagc gaactgtttc agcttctata gcaatcagca ttctgttcat gtcaataaga 3601021 aagttagcat ttgattgata ctccggaatt atagaatttg atagattccc gattccttct 3601081 ggatgataac tcatctcaaa tacttgccaa ttgtattctt ccggatctat tttttccaat 3601141 ctcatgtcgc caacatctgc actataataa gcggatgcca cattttgaaa tgaaatttta 3601201 tgcgtatatt caccttcatc ttcaaaaacc ttaatatcaa gtgagagttc ttttttaaac 3601261 acattaaaat ctaaatgaag gacactgcac cccttatcta tataatcaac ccattcatta 3601321 atcgtttgat acattgtcat cccctgcctc tttttaaaca ataacgcctt gccaccaagc 3601381 agaaaacaaa ttactccgta tattgtttga tccaatcatt taaatcatct gttgaatgca 3601441 aataagtttc tgatgaatct ttcaaatcaa tcccacttag aaggattaac atatcccaga 3601501 ctctatcgtc ttctacttcg gggtcatccg cataaacata agttccagcc caatccgaca 3601561 cttcttctct tgttgtttgt ccatttaaga cacttttgat tttatttatg cattctatta 3601621 gatttgtctc gctcaatttg atcaccacgt attcaagtac taaatgattt tttattagta 3601681 tgcaaagcac cgtactgata tttagatatt gaagcttttt ccgtaaaaga tatgttccaa 3601741 aaggtttcca atctaccaat aaacaagctc acatccgtat tccgtgtgca atatacataa 3601801 accaaactgg cacttaggct caaccaaaat aaaactatga ttgagaatcc cttcatcgaa 3601861 ctcaatacac tccaataagc agtcaaggtg ctcgagacat tttccaaaag aacaaactaa 3601921 cgcaccaatt tcgctgctgt attgatgaaa cagcagaacg tcccggtcat cgtaagcaac 3601981 atatgactga gatattttcc agatcagctg tttcgcttcc gttttttcga gggcatcaac 3602041 ctcacgggtg ttggctggta ttgaatttga taaaaccagc tcaagcaatt gcctgctttg 3602101 cgccagatca gcaaaacgat aagtgaagcc tctttctgca caagggacta gtttttcttt 3602161 gatttcgctc atcaataaac gtcttttatt ctcggcgagt ttttcgatca atcttttttg 3602221 catgagccgc attccctccg ctgtcaattt ctcaacttct tttaaattga ttcatcattc 3602281 tcttgttttc gttgtcgttc atgtttagat ttgttctaaa aaagcttgta tcgcttatcg 3602341 atacaagctt tatcttcaac tgcttaaaac tcacccagtg ggcttttcac aaaacgctgg 3602401 gaaccttttt ggcaaatcct cttcatccca atcaattcta tatttttaga ttcttttgtc 3602461 atacaaataa gagaggatgg taacatctct tatttaatgt tccatcaata aatgccccat 3602521 ttttatccaa tgcagaaatt atttataatt aaggaagttt agaaggattt tttgtatttt 3602581 caagatttaa ttttaaagcg gtcacaaaag actctagctt ttcttcatta caattaattt 3602641 cgaacaagtt ggagttcgac ttactttctt tataatcatc aaatataatt ttaatcttaa 3602701 ttctgtaatt tccgttttct tgatcaatac taagaaataa gaatggttca atagtctcta 3602761 aactgatact gtcttgattt ccttttatca tagtttcgat cccagatatc aacaccttat 3602821 attcactttc taataaaaca gcagaaaaat cgcgaacgac ggctttctta ttttccaaca 3602881 attcaaatac agataaaata aatggatcat cgtccaactc ttgatacctt ctcggtgtta 3602941 attcaagttc tatacaatca tcttttattt tggccatatt tcctcctcat ttaaagttta 3603001 agtgagggta gttgtcatcc ccccctcgct taaccttatt aacgccttct cttagattta 3603061 tttccttttc cgtgtgtatg gaatacgtgt ttagaaccct tagctcttga acttccataa 3603121 gctgtgatta ctttacccct tttatttaaa acaactgtag ctttttttcc aacatatttc 3603181 gttgccccat taggttgttt tattactttt ttagggcttc gcacagcatt cagtttggcc 3603241 cttaaattga ctccacggcc tccatttctt cctatagatt gattaagtcc atgtcttgta 3603301 tgacctgtga ttttaactgc cttcttcgta aacttatagg cgcgactagc acccttaaat 3603361 atcttcccag gaccaaaatt agaagcagct gcccaagcag cacctttcca tcctttacct 3603421 gatttatatg ccttatatcc atcataggct gcaaatccgg catttaccac aagccatacc 3603481 caatgcccgt ccggatcaac attcatcact gggttattat ttccataagc atacccattc 3603541 tgatccaatg aatctccgtc gctgcccggg tctgggtcga gcgataggaa cacgccgttt 3603601 cttggctcgt agtagcgggc catgagatag tacaggccgg tttcttcgtc gtattggtag 3603661 cctgcgtagc ggtagcgatt gtcttttact tcgtcgcttg cttcggtttt tgttggattt 3603721 ccccatgcgt cgtattgata cttggcaacg gtttttccag tgctgtctga gatcgcgatg 3603781 atgtcgccgt gagcgttgta gtgatagaaa tatttcttac cattttctgt gtaggataac 3603841 agctggccgc tgtctccgta cgtgtatgat tttgtgacgt tgttgtccgc gtctgtttca 3603901 tacaagacgt tcaagctgtc tccgtcgtag aagtagttcg tgacttttcc gttgacggtt 3603961 ttttggattc tgtttccttt ttcgtcatac ttatatgttg cgaatggctt gtcttcgcct 3604021 tttttggtaa cggcggtcag gttatcttct gcatcccacg tatatgtgaa tttgccgtcg 3604081 gatgtgcggt tgccgttttt atcgtaagag atgctttcat cattgacttt tgtcagctgg 3604141 ttcatgatgt tgaaggaagc gttcaccgtt ttgcttgagc cgtcttttat agttgtaacg 3604201 gttttccggt ttccgaatcc atcatatgtg tattcaataa cagtaccgtc ttcatgggtt 3604261 tctttgacaa gctgattcag cttcccatac tcatattgca ccttgccgct tgctgagctg 3604321 tttatcgttg tgcggttgcc gttggcatca tattcatagc tttccgtcag aatgtctccg 3604381 ccgtttttgt caccgatatg cagcgagctt acaaggtttc tttcgtcata tgaaaaactt 3604441 gttccgccgc cgttgcccgt aataaaggtt tggacgtttc cattttcatc ataatcaaat 3604501 gaatatgagg atgtactgtc tttcatctca atcatttgat ccagcttgtt atacgtaaat 3604561 tgattcgttc ctttttggtc cccatgaatc cacgagaagg ttttcagctt atcggagtca 3604621 ctaggatatg tccaagtttg gctgccgccg cggtctgtca gttcggttaa acggtttttg 3604681 ttgtcaaatg tccgtttctt tgtggtgttc tgctctttat tgacgaccga cgtttcattt 3604741 ccatttttgt catacgtgaa aatgtacttt tctgtaccgt tatacgactt tgatttcacc 3604801 cggtctgttc catcataaga aagagacact tcgttgccat ttggtgaaat ggttttggtc 3604861 aggttgctgt tggcatcata ttcgcttgct aacacattgc cgagagggtc agttgttttg 3604921 acaagcttgc ccatgacatc atattcgaat ttataggttt gatctgctcc tgcccggatg 3604981 gttttgctta cctcattgcc ttccttatca tagctgtgaa ggatagacgt gccgttagag 3605041 agcgtcatgt ttgtcaattg gtctgcctga tcatacgtat aggttgtttt ttcacctttt 3605101 gcatctgttt cagacgtttt cttaccagtt tcatcgtaat cagttgaagt ggcgtaacct 3605161 agttcgtcct cttccttggt cacatagttg ccattactgt catacgtgct tttagtcaga 3605221 aggcttcctt caatcaaacg gatatcatca aaccagactg tgcctgtcgc actcttttgg 3605281 aacagaatac tgatatcgac tttattgatc ggctttgttt tagggatgac gacagctgct 3605341 cggttccatt cctgtgttcc agaagggaat ttcgcattgt agatgcctgt gctgccgtca 3605401 gcgtaagtga cattcgcctg cagagaatag tctttttcat ctgtaaattt gacgctgctt 3605461 gctttcgaca ttcctgtcag tgtgagataa accggtttgt catttgcgct ttgccctaag 3605521 acaacggttt gttttgttac tgatccggct tgggacgcac tggtccgggc agcttttaat 3605581 gatacatcat cattaaagcc ttcttcagaa tcaacggatg ctccgcttac attccagttt 3605641 tccgttgctg atgtgaagct gctgttttga actgggttat agcttgatga tacttcgcct 3605701 ttttccagct ggacttcatc aaaccatgct tttcctttgc catctttatc tttatgatcg 3605761 acttccatat acacaacagc tttgcctgca ttcgctggag tcgtaaaagt gatttgccgt 3605821 tttgtccagt cattttttcc ggctaatgca ctgtattcat tgtgaatcca ttgaattcgt 3605881 ttttgatctt tgtctcgcaa atcaatgtta aaataggctc ttgatttcgc aagatctgtt 3605941 ttgattttcc cgcttaatgt ataggttgta ttcggctcca gctcaactgt ttgtgttgct 3606001 gacgaatacc catgatctgt tccggcagac gttgattggc tcaagacctc caatgccttt 3606061 gatccggaaa gaactccgct tttatcggcg atgactgaaa ttttgccgct gtctttagag 3606121 gcagtcagat tccagccgga tttttgagct tcaaagcttc catctttcaa aatattagtt 3606181 gaagctgata aatctttgct cgattgaatc tggtttccat atttatcata aacagctgct 3606241 gacgatgatt ttccgctctg atcggtttcg gatacagcat ccagtccgtc ataagcaata 3606301 tccgtgacat tgccctcggt atccttcatc tttgtgacat cgttgttttt gttgtattcg 3606361 tatgtctcag ttccatatgc atctttaacc gacgtaacgt tgccatcttt gtcatattga 3606421 tagctttccg ttgcttttcc ggtgccgacg tcatttggat ctacatcttc tacaacattg 3606481 ttgccttcat actttgtatt cgttgtaatt tttaaccctt ccgcatcatc aatgacctga 3606541 atcggatttc ccgcttcatt atagccatac tgtactttcc ggccatttgg ctgtgtcatg 3606601 agaagcgtct ttttatcagc atcatagctg tagacatatg tttctttttt agcgttgatc 3606661 gctttttcga gacggtgacc gctatactga tattcggtaa agacaggctt tgcttcggta 3606721 ctgttagctg aatattgttt gacaaggcgc ccttcactat cgtagtcata gcttgtgaca 3606781 gtcccgtctg tatctgtaac cttcttcagc aaatcattct catatgagta ggtgactttc 3606841 ttattcttag gtcctgtgat ggacgtcaca tggccgtttt catcataggt aaatgtaagc 3606901 ttgcggcctg atgcatctgt aatggcggtc agttgatttt tgtcattgta agtatagaca 3606961 gttgcattgt tatggccatc cactaccttt tggagtttgc cgcctttttt attgaaataa 3607021 gcgttggttt gatcctttgt ttttaatatg aactgatcag ctgtttctgt taattcaaga 3607081 tatacaccgg tcggcggctg atacgtgcca tcggcttttt tcgtgaatcg atgtgtcgta 3607141 gcgtcttcat cgatatacat tgccccgcca tccgttgaga tgacagatgt ttctgcatca 3607201 gcataccagc cttgtccaaa taagtgatca gagctgtcaa gactgttgta ggttctcgat 3607261 aagccaagtc ccggaccgcg tccatcaatt gacaaatctt cttcattcac aatgacattg 3607321 cctgtcgcac catttaactg gccgcttggg atatcaatga tagaccagta ctcttctgta 3607381 cctaggaatt ctgcgccttc atggaacgtt gggttaaagg gcgccgttgg aatcgtttca 3607441 ccattcgcat cataggcgac aagcgtgaaa gaataattct tcttcccttt gtaattccca 3607501 tttgcattgt tatagacagg tgatggatcg agggctaatt ccccgccttt tccatctgta 3607561 tgaagcttat agcttccggc tttgatttcc tcagaagtcg gccagatgtt tttattttgg 3607621 gttgtccaat gatcagcatc accaacatca aaggactgat attctttacc gttgtaaatg 3607681 ttaactttat agcccttcgc attttgaacc ttttcccata tcaaattcac ataacccgtt 3607741 tgactcgatt ttgtatttgt atacaaatag ccagttacat tctttggcct agcgatatca 3607801 ggaagtgccg gggtagcagc cggggatgca atggcttcgc cgtctttgtt gtatgcgata 3607861 attttaaacg agtaatttct tttggctcca tctcccccgg cgtttttata ggttggtccg 3607921 ggattgatcg gcagctctgc tccgcttccg tcctttaggt gaagagcata ttttcccgcc 3607981 ttgatttctg cacttgtcgg ccagatcttt ttcccttttg tggtccaaga cgtctgattt 3608041 ccgagatcaa gtgtctcaaa gcctttccca ttgaacacct gaaccttata gccggttgca 3608101 ccggatacag ctttccaaga aaggtcgaag tatcctgtgg cattcccatt attgtagccc 3608161 tttgctgacg gtgcttgtgc ttttcctaca ttagggataa cgggctttgc cggtgcggac 3608221 atcgctcctt caccttggtc aaatatcgca ctgacgccaa tccaatagtt tttgcttgta 3608281 gcatagcttc cgccggaatt cttatagacc ggggatggat ctaatgccaa ttcagctcca 3608341 tccttgccgt ccagatgcag tttatatctc ttggaggcaa tttctgcgct cgtaggccag 3608401 atttttttac cttttgtgct ccacgacgtg acgttgcctg cagaaatcgc ttgatattcc 3608461 ttaccattgt aaatccatac cttatatcct tttgcgcctt caaccttttt ccagctgata 3608521 tcgaaataac cagtggaatc gccgttgtga taggctttga ttgtaggtgt gtttcccttt 3608581 ggaatggtat acgtcacttc aatatatggt ttattggcgg agttcgctga agaaattagt 3608641 tttttccaat attccttgcc gtttccgttt gtatgaagct taaatccata gttggccccg 3608701 ccggagttcc atgactttac agcagcggtc acatcataac tcgcccactg tcctttatgg 3608761 acgtcggctt ttccgatatt tttagatgcc ggtttggtgt tccatgtcac ttttgcatta 3608821 tcataattgc tgttgaccgt atccagccaa aggccggttg cctttgttcc ataataggaa 3608881 tgggctacgt atgtttttaa tgtagcttta gtgacagtca tattttgaat tggctttagg 3608941 ttgttaaatt tcatgaacgc atagtttgtg cctgttgttt tgtcataata gcccgttttc 3609001 agtacatagg cctttaaatt agcatcccat ttttgtgagg aggccgaata gttcgtcgtc 3609061 gggtaggcac tcatgacaaa cgtatccgat gaaacagata aagaagttga cgggtcgata 3609121 gatactggat atacgcgttc tgggtctttc agccagttct cgtctgccgt aagatgaagc 3609181 aaataccctt cttcattctt ttccagctta tagctgactt tgtctgaccg ttcaacctcg 3609241 ccggaaagct catctagttt tgaatccgtc ataaaaggct taggcacaga aaaaacaact 3609301 tttccttttt catcagaaaa atcaatggat ccatcctctt gttctttagc ctgcaaatcg 3609361 gtttttaact gaaatgtaaa tgtgttgtat ccattatact gatgaaggac taaatcttct 3609421 tttatgtttt cattgaatgt gaaagtctga agatcaatat tcggaaacac atccggatac 3609481 acaatctcat tactgtcagt cttataatct gctgaggtat ctttcggagt aagtgaagtt 3609541 ttattcgggc ctttcgcttc tgctagtgaa tatgtaacct tatggtcatt atgctcaaaa 3609601 gtcgcataaa gcccgttctt catttgcttt tgaaaatctg aattcaaaat agcgttctct 3609661 gtctcgactt gtttgcttgt cgactctttt aactcaggag aaatgtcttc ccagtcggca 3609721 tccggtgttt cctttgtatg aataggatca aggtatactt cctgtttata gacaccgtca 3609781 ccttcataat agagttttgt attttctgtt ctttcagagg tgatctcacc ctctttgttt 3609841 atatcttttg gatcaaaagg tacagcttcc tcagtttgtt ctttctgaag agtttcttct 3609901 ggatcatcgg cagcaatacg gtttccattc tcttcttctg tagattttgc tagtacatcg 3609961 gctggcacta atgaaatcat taaagccaac actaaaaatg ctgcaatgaa ccttttaaag 3610021 tttcgcctct ttcttttttt catttcctct ctccttttgt aataaaagta atatttactc 3610081 aataatctta actagactga aatatcatta caatattttt ctagaaaatt tatcttattt 3610141 taaggattag cgagagtcaa ttgacctaaa acaaaaaaag gccgcatagg cctttttaca 3610201 ttttttattg tatttgttca atatccgtac cctcagctgt cacattcgcc ttcccctgcc 3610261 tcctgacaag cgtcaaggcc atgcccgcaa agatcattac gatgccaagc gtttgataga 3610321 ggtcagggcg gaagcctgtg aagacggtat cgagcacgat cgcgacagcg gggtcgagaa 3610381 atacaatgat tgaaataaat ttcgttgata aaaatcgtaa actgtcaaaa aacagcaaat 3610441 atacaatacc cgtatggatg atgccggtag ataccaccat aatccagttt ccctgagata 3610501 ggtccgcaaa agcgccaaag tgaataaacg gaatcaggat gataacccct aaacctgtct 3610561 gcaagaaggt ggtcgtgtaa ggactgagat tgtgaatgcc ttttcccaat aaagtggtga 3610621 acgcataaaa cagtgcggcg agaactgccc atatgatccc tgatcccatc agctgtgtca 3610681 atgatgtgct gccgttaatc ccggaaatca gcgcagtccc aagaaagcag atgataatgg 3610741 agctgacgga gatcacattt aatttctctc tgtagaagaa gctccccaga agaagaacaa 3610801 gcaccggcgc tagatgataa acagagatgg caattgtaac ggacgtttct tcaaaagact 3610861 taaataagaa cacccagttg aatacaagaa agaaaccgca cgccaatgtt tgcagcacgt 3610921 ctctcttgct ccatttttca gttttatact ggccggacgc cagccagcaa aagcctaaaa 3610981 acagcgtcgc gcaaaggcag cggacaaaga ccaattcaaa tgacggcaga ttggtatgct 3611041 ctgagaaaaa gccgatggag ccgaaaatca ccatagagat gaccattttg attacggctg 3611101 ttgatttttg ttttgacgat atggaaggat cctgttgcat caaacgtatt ctacctccaa 3611161 tactgcatag cataaactgt tttttgtgaa ttcagaaatc tacacataga attcctcttt 3611221 tttacatgta gatattataa cacttctatt ctaaataaaa aaaagcgccc aagggcgctt 3611281 tttttacaaa tctatcgaac aatcaaaacc gggcatgttg ataattgaga cactttatgg 3611341 ctgacgcttc caagcatcat ttctttcagg ccgctgatcc cccggctgcc aactacaatc 3611401 aggctgacgc ctttctcttt tgcgtgattt agtatctcat gcgccggctc gccattcgcg 3611461 taaatggttt cagcttgaac gcctttttcg gctgcttttt cttttgcatt ctcaaggatt 3611521 ttcaggccct cttttttaac ctcgttcctg atttcatcaa taaagtgttc aggcacatag 3611581 acaattcccg tcagagaaga agtcgtgacg acggcttctc tccccacatg aagaatgctt 3611641 agttccgctt gttgctcttt tgccaaatgc actgcggcat caagcgcttt tgcactcatg 3611701 tctgatccgt caatcgctac taacattttg ttaaacatgc tcttcccgcc tttcggactg 3611761 tgggtggttc atctttctct tttattgtcc gcctgcattt cgttattgtc aattgaagcg 3611821 catgagtttt caaaaaattg tcagagactc tctccgtttg tggcgataac ctgctgatac 3611881 cagttgaagc tttttttctt gatgcggtta aatgttccat ttccttcatt gtcccggtct 3611941 acataaatga agccgtagcg ctttttcatt tccgcagtag atgcgctgac aaggtcaatt 3612001 ggcccccatg atgtgtatcc gattaattca acgccgtccg caatggcttc gcgcgcttca 3612061 attaaatgat cacgcagata gttgattctg taatcgtcct gaatcgtgcc gtcctcttca 3612121 accttgtcta cagcgccaag gccgttttca acgatgaaca gcggcttctg gtaacggtcg 3612181 tataaggtgt tgagcgtgat gcgcaagcct ttcggatcaa tctgccagcc ccattctgat 3612241 gatttgaggt aagggttttt gactccgccc agcaggttgc cccctgattt tgcaagctct 3612301 tccggatctg tgctcgccgc catcgacatg tagtagctaa atccaatata atccaccgta 3612361 tgttctttca agagctcttc atcgccttca gccatttcaa tttcaatatt gttttctgcc 3612421 agatagcgtt tcatatatcc cgggtatgcg cctcttgcct gaacatctga gaagaaaagt 3612481 gttttgcgct cattctccat tgccgcgaag acatcctccg gcttagaagt catcggatag 3612541 gttgtcgttg ccgctatcat acagccgatt ttcgaatcag gaatgatgtc gtgacccgct 3612601 ttgacagcaa gagcactggc cacaaattgg tggtgtgccg cctggtacat cgcgtttaat 3612661 ttgttttctc cttcttcaaa aacaagaccg cctccggtaa atggcgcatg gagcactacg 3612721 ttaatttcat taaacgtcat ccaatacttc actttgtgtt gatagcgttt gaaaaccgtt 3612781 ttggcatagc gttcataaaa ctctatgact ttgcgattct tccagccgcc ataatttttc 3612841 actaaaccga gcggcatctc ataatgagag atggttacga caggctcaat atgatgcttt 3612901 aacagctcat caaacagatc atcataaaat ctgaggcctt cttcattggg ctcctcttca 3612961 tcgccattcg gaaaaattct cgtccacgca atcgatgtgc ggaacgcctt aaatcccatt 3613021 tctgcaaata aggcgatatc ctctttataa cgatgataaa agtcaatccc gttgtgatac 3613081 agattcaagg aagtcattga ttcatcaaat ggagacatga tcccgttcgg cgatacgtca 3613141 gctgtcgaaa gccccttacc accctcgtta taagcaccct ccacttggtt ggcagcaact 3613201 gcgccgcccc ataaaaatcc ttctggaaat cgtttttcat ttgaactcat attgatcacc 3613261 ccattagttt tttcaagata aagcaagcag cgcttctttt ggctgcactt taccgatctc 3613321 tttcaccggc gaaaacgaat attggtctgt gttggtcaca atcaccgggg taatgacgtc 3613381 atatcccgcg gctttgattt gctccagatc aaaggacacg agcggatctc ccggtgcgac 3613441 cttgtcgcct tctttgatgt gagccgtgaa ccattgtccc tccagcttta ccgtgtccaa 3613501 tccaatgtgt atgagtattt cagctccctg atcactcgta atgccaattg cgtgttttgt 3613561 tttaaaaatg gtggtaacgc ttccacgaac aggcgaaaca acttctcctt cttcaggctc 3613621 aatggcaaat ccttttccca tgaccccagc agaaaacact ccgtctttga cttcacttaa 3613681 ggctttcact tctcccttaa tcgggctgtg aatgatctct ctgctgcctt catgcactgc 3613741 cggctgctgg ctgccgtcag aaggcacatc ctcgaatcca agcaaatacg cagctgctgt 3613801 tcccgccgca aacgcaatca caaggccgat catcgcgtaa ataaacgttg ggccgataaa 3613861 gacagggatg ctcggcagac ctgcattccc cccgacgata taggaagcaa cacccgtcat 3613921 gccgtaaaac gcgccaccgg ctgcaccgcc aatcaaagcg gccgcaaacg gctttttcaa 3613981 tcgcatattc acgccgtaca tcgcaggttc tgtgatcccc atcagcgccg tgatgcttgt 3614041 ggtaagcgcg agtgatttaa attttttgtt tctagagcga aggaagacgg caaatgatgc 3614101 tcccgcctgc cccatattcg ccaaaaacat agccggcagt aaataatcgt ggccgttttg 3614161 agcgatgttg ttgatcatga tcggcacaaa ggcatagtgc atgcccgtca taatgattaa 3614221 agagaatgta cccgccagca aaatcattgc cacaagccct gcatgatcaa acaaataatt 3614281 gaccccagaa gacaagtatt ctcctaaaat agcgccaagc ggaccgactg taatcaatgt 3614341 cagcggcacg acaatcaata gcgtgaatgt cggaaccaca atcaatttga gagatgcgtg 3614401 tgtaaaacgg tcaatccatt tttccacgta tgaagcaatc caaatcgaca gcaaaatcgg 3614461 gatgaccgtt gacgaataag tggcagcggt tacaggaagc ccgataaagg aaatcggttt 3614521 ccccgcaccg agcagggctg tcaaatccgg atgcaggatc gccgccgcaa tggcagccgc 3614581 tacgtacgga ttgcttccga attttctcgc cgcactcatc gctagcagga gcggcaggaa 3614641 gtagaacgca ccgtcaccga cagccgtcaa aatgacatga acctggctct tctccgccat 3614701 ccagccaaac gtgactgcca gcgccacaag tcctttgatc atccccgctc ccgcaatcgc 3614761 aggcagaata ggggtaaaca ccccagaaat cacatcaaag accgcactca gcacattctt 3614821 tttctgagag gatgaaccag cgctcttttc atcactgaga ttgctgtgcc gcacaatcgc 3614881 ctgatacacc ttcggcacat cgtttccgat aatgatttga aactgctcgc cgctgatatt 3614941 ggtgcccatc actccaggca gctgctccag ctgactgcga tccgccttcg cgttgtcatg 3615001 aagattaaaa cgcagcctcg tcatgcagtg gatcacgcgc tgaacgtttt cttcaccgcc 3615061 tacgagttgt aatatgtcct tcgataattt atcataatcc atgtgtatac ctccttttta 3615121 tggggggact gctggatgaa aggtggccgc ctttcaccag ctttttttgt atcaaatgct 3615181 gcatcacctc ctaaaagaga ataaaaaaac ctaaatgaca cagattgcga gagtctcctc 3615241 ctgcacctgc accatttagg ttttgcctgc tttcgcagta acaatcctga cgggtcgttt 3615301 tatttgtttg taggtatact ttagcactag attcgtgaga tgtcaacgct ttcatttttg 3615361 gtgttgacta tcgtttctag aacaaaagta atcataaaga tttgaactta gtattaactt 3615421 caataaaaaa ttattgtaat taaaaacctt gaaaggcatt ttttccaatc aaggttatga 3615481 atcgttaccg tttaaatttt tttaaagact tctttatctg tactattaca ttctttagcc 3615541 aatctattgg ttctaaatta aacgcaggaa gatacacgcc atctgcgcaa gattgaatgt 3615601 aatcgttttt cttattgtct gaatgctcac tttcaataaa atccgttaaa aagacaatag 3615661 catcctccaa atattcctta ctttcctcta ttaataactc ttgtatagcg tcatcaggag 3615721 tttcaatatc ttgatggaat gttccagcta aaaactgaaa aacagggtcc ttctgtttat 3615781 tgatcaataa catgtcatct tgctccttta agggagaggt aacgggataa tgttaaaatc 3615841 attcatcatc taataaatca agataatact gatcattctc ttctattttt cttaagaact 3615901 cggtaagaga agttgcaatt tgaatatcat aatagtaaat cggattttta ttattatcat 3615961 ttaattcaat tgacattaat gccgattcac taccttcaaa aaatattaat ttatcattct 3616021 caaactcatc atatatttct atgtcaggat aaaattcaaa gtcatttatc ctcaatcgaa 3616081 agtctcttac agaatatgga tccaaaatgc gattagtatt aaactctgat cctttaataa 3616141 acccatagcc aacttctaaa taaaaattca ctaattcact aggtaatttt aagtttaaat 3616201 ttttttcaac ctcttcaatc tcactttgat tcactggata aaaatcattt tctttgtttg 3616261 attttataaa attataactc attttttttt gcctccttta aataattcat ttgctggtga 3616321 gcctgtacca tgaatcccag cttgatgctc gttaggaaat tttgctggat gcatattcca 3616381 ccattcatgt tctccgccaa aagtattttc aattatatgg tgagcatcat acttatcccc 3616441 tttttttcta ataattttac ctgttttttc agatacaaca ttttccttat aaacaggcca 3616501 tttttgtcca gtgttttctt cccattcttt tataacttta ttttttactt tatcaaattt 3616561 agtcctgtgt tttgcagtct ctattggtga cattttttta tattctttat ttcttaatgc 3616621 ttcctttaat ttatctattt gatttttagg taattctcta cctgtgcgtt gttctatatc 3616681 tctagcatac ttttttatta aatcagaatt aattttatta gcagatccac ttacatcatt 3616741 cgcaattttc cctttatcct tagcaacgtt tttaacttcc gaagccttct tagccttttt 3616801 cccattatta ataagtttat taatatctat taacttttct aacttagcta ttttggcaaa 3616861 tggtactgag tttatggagg caacaacacg gtctttccct gtgacttttt cgcctgatac 3616921 cggatctctg cccgtggctg ctttaaatag atcatacacg ccggtaagtt ctacagccgt 3616981 ctctaaaatt ttcacatatc cattctcatc cactttaatg tccgaaagcg agacgacagg 3617041 ttcaagcttc atgtcattac cagatatgta tacattgtaa agtgtatcat tataaacgac 3617101 ttgcttaacc tctgcatttg agaaatcagt ttttatatgt tctctatgtt cactcgtatt 3617161 atacacttta ccattgataa cgatgatatt tttacttacc tttttagaat cacccgtttt 3617221 gacaactgaa tccactttag acttttcatt ctcggctaat ttcttcagca tcatctccat 3617281 cggtgaatca tccgcctgct tcatttgcgg gttaatcgcg ccgaagattt ggttgatgtt 3617341 ttcttcttcc tgtgatttca ggatggagcc gcttttgtag cctgtgattt caattttcgg 3617401 gccggtgtac atggtttcga gctgatcaat gtattttttc atcgtttgaa aatctgattt 3617461 tgcggcttct agtgcttggg tttgctggcc gtcaaattga aagagcttat tcagggtgtc 3617521 tgaaatcagc cgctcagcct gttctgtttc catccgaaaa aaggaatcat tgactgtcgg 3617581 caggctgacg atgtgatcta tggctgatgt ctggcgattg actgcgtcag tgagctgctc 3617641 tgtcacttct cgtgcatgct tgaccccatg tctcgcatcg tgtgagagaa aagcctctgc 3617701 gatcatgccg tgggagttag attctacaga ggaaatcgca tgctgtgttt gtttcagcac 3617761 ttttttgtat tcgtcgataa atatgccaaa gaaaaggaga aaaggcttgt ggcactcctc 3617821 gtaaaaggtc cggatggcat ctccgccttt tcctttcagc gcatccttca tgcctgccag 3617881 atgctcaacg cttttttcca gcttctccag ctgttgtttt tgcttgtcca gtttctcaat 3617941 cgtatgctga atgccctcgt gaagagcgtg gacatctaat gttttcaatc ccttgtcctc 3618001 ccgcgcttta tttcatggaa gatgatatgt tttcgtccgt ttccttcatg gcgtttaccg 3618061 cgctttccgt ttgtgcgata tgcttggcca gaacagacgc atatgcttca gtgagctctt 3618121 tgatgtcctt atttaattgc tcgatggact tcacaacatt caaatggttt ctgcctgaga 3618181 gatgaccggg caatgaggac ttgagttcag ctgaattctt gagctgagaa agcccttgct 3618241 tcactgtgtc atacaccatt ttaatttcct gtgccatttg tgctcacctc actttttatg 3618301 tttttccttc tctatttcat gctctatcct cgtgatttgg cgtcttatag aatacacatc 3618361 gccctctaat gagtggattt ttccttctat gctttcgatg attccgctga cttgatcgct 3618421 tttgatttgc tgatatgctt tgttcattcc ttcacgaata tcttcaaacc gctcagcatg 3618481 tgttcctctc catgcctccc ggttaagatg aggccggtga atgagatgct gggcctcaga 3618541 gaaatcgtgt ttgatttgcc taatttcgtg cagcactcgt tttaattgat ggatctgttc 3618601 ctgcttttca tgtaagtcgg cttttaccga atgtaacaac atttcactat gcatgccgca 3618661 acacctcgtg tttctatcaa actgtgtaaa ttctttacaa tacagactat tttcatatta 3618721 catgatgggt catattggat aaataggtaa aaaggattgt cttgagaggt atagaactgg 3618781 ttctaaattg ctaaaaatac gatctcatca ccctatgaaa ggagaaaaca atcatagtag 3618841 ggacttttta tttaagcctt taatctctcc tccagttcta atttttcctc ccacttaact 3618901 gtttcttata gtcaataaag ctcataaaaa aacaccttcc ctcgaaggcg cttctccatc 3618961 ttatttagat ccccatacag cctcaccgct ggtattcagc acactaaacg tcatgacgtt 3619021 cttctctctc accgaatccc actggcgtaa aaataccccg ttatacttct tgcctgctaa 3619081 cgtgatgtcg gcggtgtttt ttccggtttt cctccatgtt ccggtcattt ccccggaaat 3619141 ggtgtggttt ttgttgagct ggatgttgat ggtttgtttg atgtcggctg agatgtcttt 3619201 tccgtgctgg ataagtttgt atgttcctgt gatgtctttt tgttttactt ctttcaatgt 3619261 ttcgcccgca taacgatatg gtgctgctac cggccagccg tctttgttca tgaacaattg 3619321 gtggactctg acttcgtgtt cttcacccct gcccgggaag cgggtgtgga agattaaata 3619381 ggaacgcccg gttttttcat catagtatgc ggagttgtgg cctggtgaga cgtacccggt 3619441 gcctttttca ttttctgttt caaaagtgta gctgcccatg agtttgacgc cgtatggttc 3619501 gatggaacgg tcgtcgaaga atgtgcctcc cttgccgcgg acgtcgagca ttggattgcc 3619561 ttctgcatca tagtaagggc cgtccggttt cttggagcgg gccacacgga tgttgtagcc 3619621 gcctgttgca tcgagaccgc catatgatag gtataagtag tagtattggg tgtctggatt 3619681 gtagagaaca tacgggcctt cgattctgct gtggttgccg ccgagcagtt ttttcccata 3619741 tccctgtcca ggaagcggga agcccgtttt cggattcatt tcaagtatga aaatgccgcc 3619801 tgagtatgat ccgtacacca tccacagctt gccgtcttta tcaaagaagg tatgcgggtc 3619861 gacgacattc ggatgtttgg ttgcatcata cggtgttcca tcgctgcttg tgccttccat 3619921 tcctgatttc aaaaagatgc ctttgttttt gtatgggcct tcgatgttgt cagcaacggc 3619981 aacacccatg gcggatcttg gcgaatcgcc gcggcaggcg ttgtagtaca tgtagtattt 3620041 gccgtccgcc agctgcgtga cgtcagccgc ccaaagagta tcggattgcg cccattcgaa 3620101 ggtttctttt aattcttcat agacattcgg gataagtggg ttgtcattgc ttacgctggt 3620161 ggtcagctgc tgccattgca tgaggtcatt cgatttagct gaagcgagat gagatccaaa 3620221 aacataaaaa gtgccgtttg tttcaatgat ggaagggtca tggacgctga cttctttaaa 3620281 tataggtttt tgtgcataga cggagtttgg gagggtgaag gccatgataa gagctgcaag 3620341 aaaacataca cggaacaatc ggttgaacat ctaaacaatt cgcctctctt ttttattaaa 3620401 ttttaaacgc ttacatttct ctatgaagat accccggcct attaaaacag ccgaatgttt 3620461 tcatattcat ccagataggt gatttctcac ttcacttaca tagtcagact gatgtctgtc 3620521 tgttttgcgc agaacttgtt gcttgcatat cctctccttc atagttcaac tcttttgctg 3620581 tttctccttc ttgcatcacg tctgtttttc tttcgcgtac atgtaataac tgctttgtca 3620641 ggttttgcat caactgtgat acagccattt cgttgtcggc gttttttaag atgatgcctg 3620701 attgcccgtc aacaccagag tcattcggct ggctctttat aaaacgcctt gcgaaaaata 3620761 cgacttagta aacgcatatt gagagttaga cagcggcgct tgcctccttg tctggatatc 3620821 gtgtgcaatc gctgaaaaaa cctgttctgc tttctgcgtc acgctattac aatagcaatc 3620881 taacttgtta aagactataa aaaaaccttt tgacttctgc tgctgaacca attaatataa 3620941 tactcagtta atagttatca gaatttttag gaattgagtg attcatatga cactgcataa 3621001 agagcgtcgg atcggccggc tgtctgttct cctgctgctg aatgaggcgg aagaaagtac 3621061 gcaggttgag gagctggagc gagacggatg gaaggtctgt cttggcaagg taggatcaat 3621121 ggacgcacat aaagtagtag ccgcaattga aaccgcttcc aaaaagagcg gtgtcattca 3621181 atctgagggt tatcgggagt cacatgcgct ttatcatgcg acgatggagg ctttgcatgg 3621241 cgtgaccaga ggtgaaatgc tgctgggatc gctgcttcgg acggtgggat tgaggtttgc 3621301 cgttttgagg ggaaatcctt atgaaagtga agcggaaggc gattggatcg ctgtctcgct 3621361 ttacggaaca atcggggcgc cgattaaagg tcttgagcat gaaacattcg gcgttggaat 3621421 taatcacata tgaaacagcc catagatctt agacgatagg gggctatgcg tgaaaacaga 3621481 agttcacagc atagctcctt tttgtatggg cgctttacca aagtaaagaa aaaggagttg 3621541 ggcttatggt gactttagac ggttcttcat tgacaacagc cgacgtcgct cgtgtgctgt 3621601 ttgattttga ggaggcagcg gcttctgagg aaagtatgga gcgcgtgaaa aaaagcagag 3621661 cagcagtgga acggattgta cgcgacgaaa agacaatcta cggcatcaac accggatttg 3621721 gcaaattcag cgatgtcctg attcagaaag aagactcggc ggcgctgcag ctgaatttaa 3621781 tcctttctca tgcctgcgga gtcggcgacc cttttcctga gtgtgtttcc agggcaatgc 3621841 tgcttttgcg cgccaatgcg ctgttaaaag gcttttccgg tgtacgcgct gagctgatcg 3621901 agcagttgct tgctttttta aataaacgcg tccatcctgt catccctcag caaggatcac 3621961 ttggcgcaag cggagatctg gcgccgcttt cccacttggc gcttgcgctg atcggacaag 3622021 gagaagtctt ttttgagggg gaaagaatgc cggcaatgac aggcttgaaa aaagcaggta 3622081 ttcaaccggt aacgctgaca tccaaggaag ggcttgcctt gattaacggg actcaggcca 3622141 tgactgcaat gggggtggtc gcctacatcg aagctgagaa actagcctat caaacagaac 3622201 gaattgccag cttaacgatt gaggggttgc agggaattat cgatgcattt gacgaggata 3622261 ttcacttagc ccgcggctat caggagcaga tcgatgtcgc agaacgaatt cgcttttatc 3622321 tatctgacag cggcctgaca acctcccagg gagaactgcg ggtacaggat gcctattcat 3622381 tgcgctgtat tccgcaagta cacggtgcga cttggcagac actaggatat gtcaaagaaa 3622441 aattagagat tgaaatgaac gcagctacag acaatccact cattttcaat gacggtgaca 3622501 aagtgatttc cggcggaaac tttcacggac agccaatcgc ctttgccatg gattttctga 3622561 aaatcgcaat atcagagctt gcgaatatcg cagagcgtag gatcgaacga cttgtgaatc 3622621 cgcagctgaa tgacctgccg ccgttcctga gccctcatcc cggtctgcaa tccggtgcaa 3622681 tgatcatgca gtacgccgcg gcctcactcg tttctgaaaa taaaacactg gcccatcctg 3622741 caagtgtgga ttccattccg tcatccgcca accaagagga ccatgtcagc atgggaacca 3622801 tcgccgctcg gcatgcttat caggtgatcg caaatacaag gagagtcatt gcgatcgaag 3622861 ccatttgcgc attgcaggct gttgaataca gaggcataga acatgcagcg tcctatacga 3622921 aacagctttt tcaagaaatg agaaaagtcg tgccgtccat tcagcaggac cgtgtttttt 3622981 cctatgacat tgaacgcttg actgactggc tgaagaaaga atctttaata cctgatcatc 3623041 agaataaaga actaaggggg atgaacatat gactgatgta aaaaaatcaa tccgtgccaa 3623101 cagaggaaca gagcttgaat gcttaggatg ggagcaagag gcagtgcttc ggatgcttcg 3623161 aaacaacctt gatccagaag tcgccgagaa gccggaggac ctcatcgtat atggcgggat 3623221 tggcaaagcc gcacgggatt gggacgcttt tcacgccatt gagcattcct tgaaaacatt 3623281 aaaaaatgat gaaacattgc tcgtgcaatc cggaaagccc gttggcatgt tccgtacaca 3623341 cccgcaggcc cctcgcgtgc tcctagcaaa ttctgttctt gttccgaagt gggcagactg 3623401 ggagcatttc cacgaacttg agaaaaaagg gttaatgatg tacggacaga tgacggctgg 3623461 cagctggatt tacattggct cacaaggcat attgcaagga acctatgaaa ccttcgctga 3623521 gctggcgcga cagcacttcg ggggcagctt aaaaggaacg ttgacgctga cagcgggtct 3623581 cggcggaatg ggaggcgccc agccgctgtc agtcacgatg aatgaaggcg tcgtgattgc 3623641 cgtcgaggtt gacgagaaac gcatcgacaa gcggatcgaa acaaaatact gcgatcgaaa 3623701 aacagcatcg attgaggaag ccttagcttg ggctgaagag gcaaagctgg caggaaaacc 3623761 tttgtccatt gcacttctcg gaaacgcagc tgaggtgcat cacacacttt tgaaccgagg 3623821 cgtcaaaatt gatattgtga cagatcagac atctgcccat gaccctttaa tcggttatgt 3623881 tcccgagggc tattcccttg atgaagctga ccgtttgcgt caagacactc cagagcttta 3623941 cgtgcgcctt gcgaagcaaa gcatgaaaaa acatgtcgaa gccatgctgg cctttcagca 3624001 aaagggctct attgtatttg actacggcaa caatatccgg caagtcgcaa aggatgaagg 3624061 gctggagaat gccttcgatt ttccggggtt tgtccctgcc tacatccgcc ccttattctg 3624121 tgaaggaaaa gggccgttcc gctgggcggc gctttccgga gatccggcag atatttaccg 3624181 tacggatgcg ttattaaaag agctgttccc gacaaataaa gcccttcacc gctggattga 3624241 tatggcacag gaaaaagtca ccttccaagg cttgccgtcc cgtatctgct ggcttggata 3624301 tggagaacga aaaaagatgg gcctcgccat taacgagctg gttagaaccg gggagctaaa 3624361 agcgcctgtc gttattggga gagatcattt ggactgcggg tctgtcgcct ctccaaaccg 3624421 ggaaacagaa gcgatgaagg atggaagtga cgctgtcggt gattgggctg tgctaaatgc 3624481 gcttgtcaac acggcggcgg gtgcaagctg ggtttccttc caccatggcg gcggcgtcgg 3624541 aatgggctat tcccttcatg ccggcatggt tgcagtggcc gatggaagtg agctggctga 3624601 cgagcggctc gcgcgggtct taacgagcga cccaggaatg ggcattatcc gtcatgcgga 3624661 tgcgggttat gaacgtgccg ttgaagtagc gaaggaacag gacattatcg tgccgatgca 3624721 aaaataaagg agtgatgaca tgccaaagca aattgatacg attctcatca acatcggtca 3624781 gcttttgacg atggaaagca gcggtccgcg ggcaggcaaa agcatgcagg atcttcatgt 3624841 gatcgaagac gctgttgtcg gcatccatga acagaaaatt gtgttcgccg gacaaaaagg 3624901 ggctgaagcc ggttacgagg cagacgaaat cattgactgt tcgggacgcc ttgtaacgcc 3624961 tggcctcgtt gatccgcaca cccatcttgt atttggcgga tctcgtgaaa aggagatgaa 3625021 ccttaagctt cagggcattt catatttgga tattctggcg cagggcggcg ggattctgtc 3625081 tacagtcaag gataccaggg cggcttcaga agaagagctg ctgcaaaaag cccattttca 3625141 tctgcaaaga atgctgtcct acggcacaac cacagcagaa gtgaaaagcg gctacggctt 3625201 ggaaaaagag acagagctca aacagttgcg tgtcgcaaag aaactgcatg aaagccagcc 3625261 tgttgacctt gtttccacat ttatgggagc ccatgcgatt cctcccgaat atcaaaacga 3625321 tccagatgat tttctggatc aaatgctttc ccttttgccg gaaatcaaag agcaggagct 3625381 cgccagcttt gctgatattt ttacagaaac aggcgttttt acagtcagcc aatcccgccg 3625441 ttatttacaa aaagcagctg aggcaggctt cggattaaaa atacacgcag atgaaatcga 3625501 tccgcttgga ggtgctgaat tagcaggtaa gctaaaggcc gtctcagccg accatttggt 3625561 aggtacatcg gacgaaggca taaagaaatt ggctgaggca ggaacgatcg ccgtcctctt 3625621 gccgggcacg acattttatc ttggcaaaag cacatacgcc agggcaagag ctatgattga 3625681 tgaaggtgta tgtgtcagct tggcaacgga ttttaatcct ggcagctcgc cgactgaaaa 3625741 tatccagctg attatgtcca ttgccgcgct tcatctgaaa atgactgcag aagaaatatg 3625801 gcacgcggtc acagtcaatg ccgcatatgc cataggaaaa ggagaagaag ccggtcagct 3625861 caaagctggc cgctcagctg atcttgtcat ttggcaagcc ccgaactata tgtatattcc 3625921 gtatcactac ggggtcaatc atgtacatca agtcatgaaa aatggaacaa ttgttgtcaa 3625981 cagggaggga gccattcttg gataagtacc cttttctcag agaggccgga tcttcgttta 3626041 aagaccggga tgtcacaaaa atgagcgacc tgatcgcaac atgggacggc caggacatta 3626101 agggaccggc gttgataggt gtccccctat caaaatcctc catcagtcat tcaggcgctt 3626161 cctttgcacc cggaacaata cgccaggctc tgaaacattc atcagcctat tctgctgagc 3626221 ttggagagca cgtcgtatca gagcttctat atgacctggg ggatatcgat attcatgtca 3626281 ctgatatcgt aaagtcacat catcacattt tccaaaccat gcacgctctg ctttcggatc 3626341 atccggattg ggtgccgctc atacttgggg gagataactc tatcagctac tccacaataa 3626401 aagcgatagc acaaacaaaa ggaacgacag cggtgattca atttgatgcc catcacgatg 3626461 ttcgcaatac ggaggacggg gggccgacaa acggcacccc cttccgccgc cttttggatg 3626521 aagagatcat tgaaggtcaa catttgatcc agctgggtat cagagaattc agcaacagcc 3626581 aggcctatga agcatatgca aaaaaacata acgtgaacat tcacacgatg gacatgatcc 3626641 gggaaaaagg actaatccca acgataaaag agattttgcc tgttgttcaa gataaaacag 3626701 atttcatttt tatatctgtt gacatggatg tcttagacca gtcccatgca cccggctgtc 3626761 cagcgattgg cccgggcggc ctctatacag acgaattgct tgaagcagtc aagtacatcg 3626821 cacaacagcc caatgttgcc gggattgaaa ttgttgaagt cgaccctacc ctcgattttc 3626881 gagatatgac aagcagagct gcagctcatg ttctgttaca cgcattaaaa ggaatgaaac 3626941 tctccccatt caagtgatct tctggcaggt tgtattttgg gtataagaaa ctcatctgcc 3627001 taaggaatgg cagctaaaag gagggcgaga cagtgaatct tcaggagaac agcagccaac 3627061 agctaaaacg cacaatgaaa agcaggcacc tatttatgat ctcattggga ggcgtcatag 3627121 gcacaggact tttcctcagt acgggctata cgctacatca agccggaccc ggcggtacga 3627181 tactcgctta tgtaatcggc gggttgatga tgtacctcgt catgcaatgt ctcggcgaat 3627241 tgtcggttgc catgccggtg accggctctt ttcaaaaata tgctacaaca tttatcggtc 3627301 catctaccgg ttttatggtc ggcatcatgt actggatcaa ttgggtggtg acggtaggct 3627361 ctgagtttac cgcatccggt attctcatgc agcgctggtt ccctgacagc agtgtatgga 3627421 tgtggagtgc gatttttgca gcccttcttt ttatatgcaa cgcattttca gttaagttat 3627481 ttgcggaaac tgaattttgg ttttccagcg taaagattgt caccattatt ttatttatca 3627541 ttttaggagg agccgccatg tttggcctga tctctttaaa cggaacggcg gatgctccta 3627601 tgttgtcaaa cttcacagat catggcgggt tgtttccaaa tggctttctc gccgttttta 3627661 tcgcgatgat atctgtgagc ttcgcctttt ccggtacaga gttaatcggc gttacagcag 3627721 gagaatcagc aaatcctcaa aaggatatac cgcgatccat ccgtaatgtc gcatggagaa 3627781 ccgtgatttt tttcattggc gctgtcttca tattatccgg gttgatttca tggaaggacg 3627841 caggcgtgat tgaaagcccg tttgtcgccg tatttgcgga gatcggaatt ccttacgctg 3627901 ctgatattat gaatttcgta atattaacag ccttgctgtc tgtcgccaac tcaggcttat 3627961 atgcttcgac ccgtatgatg tggtctttag caaatgaaaa catgatcagc tcccgtttta 3628021 agaaagtgac atctaaaggc attcctttaa atgccttaat gatcagtatg gctgtatctt 3628081 gtttatctct cgtttccagt atcgtggccc ctggaactgt ctatgtggtg atggtcgcaa 3628141 ttgctggatt tgcaggagtc gtggtctgga tgagcattgc cttgtcccaa ctcttgtttc 3628201 gaaagagatt tttgaaaaaa gggggggatg taaaagatct gacatttcgc acgccgcttt 3628261 atcctcttat gcctatagcc gctctcttat tatgttctgc ttcttgtatc ggtcttgctt 3628321 ttgatcccaa tcaaagaatc gcacttttct gcggagttcc ttgtatcatc ctttgctatc 3628381 tcatctacca tttcaaaaga aatgttacaa aagcgaaaaa aatcagccaa gaggaatatc 3628441 cagccgatca catcctataa ttaaaaaagc acaccccgct cagcatggga tgtgctttat 3628501 tttttattct gtaattaacg tatgaatcag cttcggcgcc ttcgcttccg cggcgatgcg 3628561 gatgttgtca tagacttttg cgatgacttc atcgacgttt tctcggttag cgtaaagcgt 3628621 tacgagcggt tccccttttt ctactttgtc gccgaccttt ttgcggagca tgatgccgac 3628681 ggctaaatcg atttcgtctt cttttgtggc gcggccggca cctaacagca tcgccgcgac 3628741 gccgatttcg tccgcgacga tttcagagac gacacccgct tctttggcag gcacatcaat 3628801 ttgatatgcg gcttgcggaa gcttagacgg atcgtcaaca attgagctgt cgccgccttg 3628861 gtttttcagg aaatccttga atttctcaag tgctttgccg tttttcatga cttcttccag 3628921 cttcgctctc gcttcgtcca atgtatcggc ttttttcgca agcacaacca tctggctgcc 3628981 gagcgttaag acaagctcat gaagatcctc aggcccctcg cctttgagcg tgtcgatcgc 3629041 ttctttgact tcaagcgcat ttccgatcgc aaagccgagt ggctgggaca tgtctgaaat 3629101 gacagccatt gtttgacggc cgacgttatt tccgatgcgt accatcgctt tggcaagttc 3629161 agctgcgtct tcttctgttt tcatgaaggc gcccgctccc gtttttacgt caagcacgat 3629221 ggcgtccgcc ccggcagcga tttttttgct cataatcgag cttgcaatga gcggaatgga 3629281 attgaccgtt cccgttacat cacgaagcgc gtacagtttt ttatcagccg gcgttaaatt 3629341 gccgctttgg ccgatgaccg caaccttgtc gcggttcaca agtttaataa attcatcctt 3629401 cgtcagttcc acgtggaagc ccatgattgc ctctaactta tcaatcgtgc cgcccgtatg 3629461 gccgaggccg cggccggaca tcttagcaac cggcacatca agagccgcaa caagcggagc 3629521 gagaacgagc gttgtcgtgt cgccgacgcc gccggtagag tgtttatcca ctttaattcc 3629581 ttcaatggca gaaagatcaa tcgtttcacc ggagttcacc atagccatcg tcaagtccgc 3629641 gcgttcacgg tcactcatat cctggaagaa aatcgccata gcaagcgcgc ttgcctgata 3629701 atcaggaatg cttccatctg tatagccgtt cacaaaaaat tgaatttctt cagtggtgag 3629761 ttcttttccg ttttgttttt tgatgatgat atctaccatt ctcatgtttg gtcaccgatc 3629821 cttttcgatt aagttcagta aatcaagccc acaattgctg ctgataaaaa gctgacaagc 3629881 gtagcaccgt ataataattt caagccgaaa cgagcgacga catttccttg cttttcattc 3629941 agtcctttta cggcaccggc aatgattccg attgaggaga agttcgcaaa tgacacaagg 3630001 aataccgata cgatcgctgt tgtacggccg ctgaaatgga aaccgttttg cgtaagcgac 3630061 gtcatggcga caaattcatt cgataccatt tttgttgcca taatgcttcc cgcattaaca 3630121 gcttcattcc atgggatacc gacaagaaaa gcgaatggag caaacacata tccaagaatg 3630181 ccttggaacg aaataccgaa tactgcatta aaaatgccat tgatcaatgc aataatcgcg 3630241 acaaatccaa tcagcatcgc agcgacgaca accgctactt tgaaaccgtc aagaatgtat 3630301 tctccgagca cttcgaagaa ggattgtttt tcttcttcct caacacgaag catatcctct 3630361 tcttttgcaa cctcgtacgg attgataata gaagcgataa tgaaaccgcc aaataagttc 3630421 aaaacaagcg ctgttacaac atattccggt ttcagcattg tcatatacgc accgacaatc 3630481 gacattgata cagttgacat cgcagatgcg caaagcgtgt acaagcgctg ctgatttaaa 3630541 agaccgagtt ctttcttcaa ggagataaat acttctgact gccctaaaat cgcagaagcc 3630601 actgcgttat acgattccaa tcttcccata ccgtttacct tgctgagggc aaggccgata 3630661 tatctaatga taaacgggag gactttccac ttttgcagaa tcccgatcag agcggaaata 3630721 aacacgattg gcaagagaac attcataaag aatgtcgttt ggtccgcatt caccaagccg 3630781 ccaaacacaa agttaattcc ctctgccgcg tattcaagca ggtaaccgaa tccttttgca 3630841 aatcctccca cgaggaaatt ccctattccg gtattgagga gaatgtagcc aagaataaat 3630901 tgcaaaatga gcataacaac aattgggcgg atcttaattc tttttttgcc gctgctcgcg 3630961 atccacgcga ggcctaaaaa cacgattaaa ccgataatcc caatcaaata cttcatatgt 3631021 gtttctcctt tatttgtatt cgcttacaat tactgtttcc tcagaaaacg gaaagcagtc 3631081 tgccttccgt cagctcttaa tagttgtctc cgcctgatgc attttctcct tttacgatag 3631141 aaacgcctgc gctggcgcca attcggcttg ctccggcctc taccattgtg tctacatctt 3631201 ctttcgttct gacgccgcca gatgctttca cgccgatatc aggccctact gttttgcgca 3631261 ttaaggcgat atcttccttc gttgcgccgc ctgtagaaaa gcctgttgat gtttttacga 3631321 aatccgctcc cgcagacacc gctaaacggc atgcacgttc tttttcttca tcagtcagaa 3631381 ggcacgtttc gataatgact ttgacaagcg cttttccggc tacagcttcc actacaccgc 3631441 ggatatcagc ttccaccaca tcgtcttcct tgtcttttaa agcggcaata ttaatgacca 3631501 tatccacttc agtggcgcct tttgaaatgg cgtcttttgt ttcgaacgct tttgtttcag 3631561 ttgtattggc accgagcggg aagccgatga ccgtacaaac gtcgactcca gttcccttaa 3631621 gctcttttgc agcaagctcc acccatgtcg gattgacaca tactgaagca aatttgtatg 3631681 ttttcgcttc ttcaattagt tttagaatgt ccgctttttg tgtatgcggt ttcaaagctg 3631741 tatgatcaat tatgttggct aatgacatcc ttcgcacact tccttttttg ttaagatatt 3631801 ttttagcata accgactttt gaacatatgt aaattggtaa ttgaaatttt gttcaatgaa 3631861 aggtttgaac gtgtcacaaa tcattaacaa gcgccctcgc ggtatgctgg tcaatgatta 3631921 aaacgttggc atattttccg gttaatgctc cgtgaatgga agatactttt ctgcttccgc 3631981 cggcaactaa aatggagcgt tccttcagtc taaggtcttg aagctcaaca ccgatggtcc 3632041 ggtcattgat ggcgctgctg caaatattcc ctttcgcatc aaaaaagcgt gaacaaatat 3632101 ccccgacggc ctgttttttc agcagggctt tctcttcttc gttaaaatat ccgagccgaa 3632161 acaacagcgc ttcatcacgg acagtcccga ccgtaaagag agcgatattc gcctgcttgc 3632221 ccatctcaat gatccgttca atatgacggt ctttctccac cattcgcttc acatccgcat 3632281 tatcaaacac gacgggaagc gggagatagc gcggcatcgt ttgaaaagcc tctgcaaaca 3632341 gctgaatcgt ttcagccgaa tacgtgttta cccgggaatg gctgatgccg cctttcagct 3632401 ggacgacctc gacgcctttt acctgcttcg gctgcatgtt ttgcgcgatt tgatacatgg 3632461 tggttcccca gctgacgccg acaatgtcgc cgtcttttac cgtttcatgc atatattctg 3632521 caccatagcg gcttaggtca tgtgtaattc ctgcataatc gggtgtcggg gaaaacacaa 3632581 catgcgcctc aaggagcccg tatttctctt caagtatgga accgagcgca tccaaatcct 3632641 caaaagggtc catgacgcga atctggacat accctttttc ctttgcatat tgcagcagcc 3632701 gggaaacggt tggccttgaa atgttgagct gctcagcaat ttgctgctga ctgtagtcag 3632761 actgatagta aagccttgcc gcttctatgc ttaattgctg tttttcccga tccattctgc 3632821 acctccctgt ggatcagtcc tgataaaact gcttttgatt tgcttttatt atacaggctg 3632881 gcgccggctt tcatccacct gatttctaag aaactgaaaa acgctctggg cgcggacctg 3632941 cccagagctt acttctccca agtcatatgc tgataaatgc ctttcataat ggcgtacatt 3633001 ccatatagga tcaggcctaa tgccaatata gacagaatca atttgccatg cggctgctgc 3633061 gcgagttctg cgagcgcgcc gtcaaagcct cttgtgtcgt cgggatcagc ggtcatggct 3633121 gtcttgatga gaaaatagcc gatagccgag aaaataatgg cccgggcgat attgcctgcg 3633181 cgtcctgtgt ttttcgtgat gcatatcatc tgtttgttca tttttgatgt atcgaattct 3633241 ttcataaaag cagcccgaac gcctttcata aattgaacaa tcgcaaatac gataaaaccc 3633301 gcacccgtaa gccctgtgag ccattggccg aacggctgcg ccaatacata agcggaccac 3633361 gtctgttctg aagtgccgcc gtccccttgg ccaaacacaa atcgcaaggc attccaagcg 3633421 atggatgtgt aaacagcggc actgaaaaag tttcctattc tccgcgacag gcctcgcctg 3633481 ctgtttccgt gcccctccgt gtccttgatc gcgcttaaca ccatccagat cacatagccg 3633541 ataaggccga tgcctataaa aaaaagcaat agtgacccat acggcatgcg tgatagcgtt 3633601 tggagagctc cgctcgaatc tttggcgcgg cctgccccgg cagccgtcat aaaagccaaa 3633661 accccaagca gaataaaaac gccgccgaat gcaaaataac caagcctccc gaatcgtttg 3633721 atccaaggct tggtttcctg ttttattttt gacatgtacc ggtctttcac cgccatgtgt 3633781 ccaaccctct ttcacagaaa tctttactgt aacattcccg attgaacaaa gttgaaacag 3633841 ctcctgcctc agctatggct ggctgagata cgtttttgct gtttagctga ttgtgcaggt 3633901 gtcatccaag cagccgctgc ggcagctgtg actccgcctg ctaatttccc aatgatcatg 3633961 gccgccgcca tttctttttt cattccagct acaaaaccga gatggctgcc gagtacaaag 3634021 gcgccgctga ccgcaaacgc gacattgatg acctttcctc tcggcgtcat atcctttaat 3634081 gaagccagca ttgggatatg atgcgccaaa gaggtcacta agcctgctgt tgctgtctca 3634141 tctaaatgaa ggcatttccc cagagcctga agcggttttt taaaggtttt tgtaataaat 3634201 gccgtcatcg ggaacgcccc tgccagagca atggcgatgg tccctgtcgt ttgtatccct 3634261 gtctcgacat tctccattcc cggaatcagc acaatgccgg tcatcgtttc aacagaaaca 3634321 gctgcaagcc cgataatcgc aaccatactg accgctttcc cgaagagatg aaacaactga 3634381 atcattctgt cggtgtatcg ccataaccca aaagcgatga cagcagataa cagactcggg 3634441 atcagaagat ttttacctat catgccgatg tcaaagcctg cgcataatcc gccgattaag 3634501 caaccgatcg gcactgtgca cagcccgatt aatatgcctt tcgcaaaata cggatgatcc 3634561 tctttttcga tgatgccaag agcgacggga atcgtgaaga cgattgccgg ccccatcatt 3634621 gttcctaaaa acacccatga aaacagcccg gcctgcggat ctttcgccat ttctccagcc 3634681 agcgcatatc ctcccatatc aatcgccaaa atggtgttcg caaaggaaga aggatccgcg 3634741 ccaatcgctg tgtaaaacgg agcaacaatg ggaatcaaga ttgctgccag cacgggcgcc 3634801 agcgatacaa ttccgatcat ggacagcgcc agcggcccca tagccttaaa gccgtccgca 3634861 aaccgctcgc ctagccccca tctgtttccc aaacaataat ccgctgctcc ccatagtaaa 3634921 aaggcagcca aaatgaatac aaccgcgtca ttcaccgtca tggttttctc ctttttcaaa 3634981 cgtatgattg gttttatcat atcatctgaa atcaccgaat agagttgatc ttattcaata 3635041 tgagctaaaa attcttttat atcggctttt tcaacggctg ttataatgcg tcgcgctttt 3635101 tcttgcggga ccgttaatgt caatttttct attatgtctt cttcagacag ctcatttcct 3635161 ggtgcccctt ttgggcagtc cacacgcgct tcgcaaatcc ggccgtctga taaataggcc 3635221 cggacaatcg tgaaacggcc ttttggaacg gcatgaggag ccggctgaat agcattgtca 3635281 tatacgcgct gaattcgccc cattgtcgtt tgaaccccgt ttgggatcgg ctggctgctg 3635341 aaatgttcaa cggtcaggcc gtgtccatgc aaagcaagag caatcacata ttcaacgctg 3635401 aaacggcctt cctctccagc ttttggagat ctttccgtca atgcagcatc tccgcctggc 3635461 ggaaatatca cttcaatacg ttcggtattg gcagcagaaa tggtttcttc ggagataagc 3635521 tgtcgtaccg catctgcagc atggtgtgcc gcggaacaaa atggatagat tttaaaccat 3635581 agacccggct gcacaattct ccacggtgcc ccccaatcgt ttagcaaagt gtgttgtgct 3635641 ttctcaacgt caccgtacag actgaagaaa ccagtttctc catcaagtgc cgtgcgggac 3635701 ccgccaaatt ctgattgggc cagcttaacg gccagcaagc cagcctgagc cgccaaaccg 3635761 gcgtgcagcg gtttcatttc tgttccaaat tgcaccctca tcccagcaga ttgcgtagcc 3635821 gcaaaaccaa ttgctttttc caactcttcc tgagtcagct cctcagcata acctacggcg 3635881 caggcagcag cgatggcacc aagcgtacct gtattatgcc agcccttctc atagtggcgg 3635941 ctgccaattg attctcccag ccgtgccatc acttcaacac caacaacata agcgccaaga 3636001 agccgctcgt catgtccgcg agcggcagaa gcaataaggg ccggtacgat gactgcactg 3636061 gggtgtcctc ttacatcgga gtggacatca tcaaaatcca atgcatgggc gataaatcca 3636121 ttgagcatcg cggattgtaa tggcgcggcc tttttgccct gtccgataac aggaacaagg 3636181 ggccggcctc cttcatcctc tatcagacgg aggagctttt gaattccttt atcttctctt 3636241 cctgcgaatg aagcggcagt aaaatcaagt aatccctttt ttgcttcgtg aatcgcgtca 3636301 actgaatgct caggttgtga cgttctcaca gcctctgcaa gacctgctgt cagcccttgt 3636361 ttgctcattt gatggtctcc aatacaataa ccgccagctc cgcaaagtat tgagaggcaa 3636421 ccgtaagggc ttcttcatcc agtgtaaagg ccggatgatg ccactcctcc gtcccgttcg 3636481 ttcccatcca gacaaaaaat cccggaatct tctcttgata cagagcgaag tcttctccgc 3636541 ccggagactg ctcagcgtga acggtttgat agccaagccg tgccgcagct tcggatgccg 3636601 cattcaaaaa tgtgccgtca ttctgaacgg aaggcaaata aggaaaccac ttgaattctg 3636661 cttgtgcccc atagcccgct gcaattcctt cagccactcg tctcatatgc tcgggaacag 3636721 cctgcctcgc ttctttttga aaggttcgaa ccgtcccctc catttcagct tggtctggaa 3636781 ttacgttcca cgaggtgccc gcctgtactc ttgtgatact gacgactgcg ttttgcagtg 3636841 agctgatatt gcggctgacc acagattgca gcccgctgat gatttgtccg gctgcagcga 3636901 ttggatcaat actgttattt gggatgccgg cgtgcccgcc tttccctttg atgacgatct 3636961 caaatcggtc aacacttgcc atgagcggac cttcctttac accaatggtc ccgacaggca 3637021 gatccggctt attgtgcatg ccgaaaatcg cagaaacgcc attaagtacg ccagcttcta 3637081 gaacctttct tgctcctgcg gcaatttctt cggccggctg aaagataaag cggactgtac 3637141 ctttcagctc ggcccttctt tgattcagca acatcgctgt gccaataata gaagcagtat 3637201 gaaaatcgtg tccgcacgca tgcattgtgc catcaacctt agatgcaaat ggaagattcg 3637261 tctgttcttg gatcgggagc gcgtcaatgt ccgctcgtat tgctatcacg gggccgtctt 3637321 cccgtccttt gatttctgca atcacaccag tcttcaattg agggacatca agtatttcga 3637381 tttgctcctc ctcaagccaa cggcggattt ttttcgtcgt ttcaacctct tgaaatgaca 3637441 gttcaggatg ttcatgaaga tcacgccgca tattgattaa acgggtatga aacgctttgt 3637501 cggccattgt tcttctcccc ttcttatata agctctgcag gctctcccac ctgcttgata 3637561 aatcgtttcg tccgttcgtt tttcggatgg tcaaacagtt cctctggcgt tccctgctcg 3637621 ataatatggc cgtctgccat aaaaatcact tgatcagcaa cctcttttgc aaacgccatt 3637681 tcgtgtgtaa caatgatcat cgttgtttgt ttttccgcaa tggacttgat gacctgaagc 3637741 acccctgtga cgagctcagg gtcaagcgct gacgttggtt catccagcaa aatcgcatgc 3637801 ggattgaccg caagcgcccg cgcaatgccg attcgctgct gctggccgcc ggacattgtg 3637861 attggatagc tgtcagcctt atgctccaga ccgacttgtt tcagaatctc cattccaata 3637921 cgtttcgctt cgtcgcgtgg tttatgttga gccacgatta aagcttctgt aatgttttgc 3637981 agagccgttt tatttttaaa cagattgtag ttttgaaaga ccatggccgt ttgctggcga 3638041 agccgatgtg cttccttgcg tgtaaacttt tccgcattca gtttggcttc tccgatttca 3638101 ataaggcctt gatccggacg ctctaataga tttaagcacc ggagaagcgt tgattttccg 3638161 gaaccggacg gaccgatgat tgccaccact tctccgcgtt tcacttctag atcgattccg 3638221 tcgagcacga cgagatcttt aaacgctttg cgaatatttt ttactgttat caactgattt 3638281 cacctctaag tccggtatgg cttgctcatg gcacgttcaa acaagtcctg caaaatgctg 3638341 tagataatgg taagaaccca atagacgatc gcaaccgcca aatacgtctc aaaatatttg 3638401 aggtttcctg aagcgtacat cttcccttgg gcgaacatct ccatgacccc taatgtaaag 3638461 gccagtgacg tttctttcag gagcccgata aatgtattgc ccgttgccgg aatcgcattt 3638521 cggatcgctt gcggcaaaat aatccgtctg tatgcctgaa attttgtcat accgacagac 3638581 aggcacgcct ccagctgccc gtcatcaaca gaattgaggg cggcccggaa gatttctgcc 3638641 aaataagctg cgttttttaa gcttaacccg atgatggcag ctgtgagagc tgtcattttg 3638701 ctcatctctg gaaatagctg cggcagcccg taatagatta agaacagctg tacaagtgtc 3638761 ggcacgcctc ggaaaaagga tatatacagc tttgacagct gatgaagcac tggaattttg 3638821 ttttttgtaa tgagtgcgag aataagtcct ccgataatgg caaaaatcat agctgctatt 3638881 gccataaaca aggtgatcgg aagggcctga attaaagtcg ggaacgctga tatcatgaat 3638941 tcccaatcaa tcgtgttcat tctggtgagt caccgccgtt tcttaatgct tctgttctac 3639001 tgtgatatct tcattaaagt atttttcaga gagttttttc agtgttccgt ctttacgcaa 3639061 ttcatctagg gccttattga cttttttgcg gagcttgtcg tgcgcatcgt ccttggcaaa 3639121 tgggaatgca acctgttcgt aaacaatcgg atctcctgca agctttaatg gcaaaccggt 3639181 cttcttgatt tgcgcgatca atacagttcg gctgttgaca taagcgtcta cacggccgta 3639241 cgcaacatcc ttcagcgtac cctcttgtgt ttcgtacgtt ttgatattga tttttttatc 3639301 aggatctttg ctttcaaggt ttttcgcgtg gtttgaaccg agaacggctg cgactgtctt 3639361 gccttttaaa tcgtctactg atttgatgtc tgtattgtct tttttgacga caatctgtgt 3639421 tcccgcataa gcgtatggtt tcgtaaagtt atacgtttcc ttacgttcgt ctgtcacagc 3639481 tacctggttg gaaatggtgt caagcttgcc tgtttgaagc tctcccatca gcccgctgaa 3639541 ttcaagcagc ttccagtcca gtttcatgtc aattttctta gcgactgctt ccatcacttc 3639601 cacgtcaaag cctgtcagct ttccgttttc tttataagca aatgggtaac tttgtcctgt 3639661 cgcaccgaca tgaagcacat tgtcatcctc tttactgctg ctgtttccat tgccgcaagc 3639721 tgagagcacc gctaataatg cagcaacgac cagcactgtc cattttttca tcttcatttg 3639781 attttcccgc cttttctatt tttatagatc atgtcgcaat tgttttttca tatagactgt 3639841 gatatgccct tttccaaggt cttgttcacc tgagcggaca tatccttttc gttcgtacat 3639901 ctcaatcagc cacggatgct tatccgctgt tccgagtgag acaaacggaa cctttaacgt 3639961 atcgcgaagg attgtttcct ccagccattg aagcagcttt gttccgattc cttttttacc 3640021 ggtgtcgggg tccacagcaa accaccagat atgcggaacg ccatacggtc ccggctgttt 3640081 tccccaaggc attctcaagg tgatggtcgc gatgatccgc ccgtcttctt ccatgacgta 3640141 gcaagcattt tcccgaatat ttttcagcac caaatccaaa tccgcatgag cagcagcaaa 3640201 acgaatgccg agctttcgaa tcggttcata agcccgcaat gtcagctcga gaagctgttc 3640261 ggcatcacgt tcaactgcaa ggcggtatcg tggcttcatc tagcgttcct ccttactttg 3640321 catagcggtt taccggcttt tccaaaccga agtgctctcg taatgttgtg ccttcatatt 3640381 cttttctgaa cacgccgcgc tcctgtaaaa tcggaaccac ttgatcaaca aacacttcaa 3640441 ttccttctgg aagaagcgga ggcatgatgt taaacccgtc acacgctttc gtatccaccc 3640501 attcctgcat cttgtcggcg agctgctccg gcgtgccgac gaagatatgg tggcctctgg 3640561 agcctgcaac gtatttgtaa agctctcgta tcgtcatatt gtcacgttca gccatctcct 3640621 gaacaagctt gaagcggctc ttcaccgcat tggaagcttc ggcgtcaagc ttcggcagcg 3640681 gcccatcaag cggatatgcc gacaaatcaa ttccgcctaa gtaattttgg agaatttgca 3640741 gaccgacaga tgggataatc agatcttgga gctccttgta tttggcttgc gctgcttctt 3640801 ctgtatcggc aatgattggg aaaatacccg gcataatggc aattttttct ggatcacgtc 3640861 cgaattccgc agcctgttct ttaatggatt gataaaattc ttgagctgat tccaggtggt 3640921 tttgtgctgt gaagatcact tcggctgttt tggcagccag cgcttttccg tctcctgatg 3640981 atcctgcctg gataatgacc ggctggccct gcggggttct tgaaacgttt agaggtccgc 3641041 gaaccgagaa atattctcct ttgtggttca gctcatgcat tttttctttg tcaaagaatt 3641101 cacccgtttc tttattacgg ataaaggcgt cctcttccca tgaatcccaa agccccttta 3641161 caatctcgac aaattcctct gcccgctgat agcgcaaatg gtgttcaagg tgcttttcac 3641221 cgctgaaatt cagcgctgtt gattcaatag atgaagtgac gacgttccat ccggcacggc 3641281 cattggacag atgatccaat gacgcaaact gtctggcaat atggaatggc tcgctgtatg 3641341 tagtggaggc tgttgctgtc agtccgattt ttgatgtgac ctgcgccaaa gcagagagca 3641401 gggtgaatgg ctcaaacctt gttaatacat ttggatgtga tttgctgtca attgaaaggc 3641461 tgtccgctaa aaacagcata tccagcttgc ctcgctccgc tgttttcgca agctctttaa 3641521 aataatccaa attcatgctc gcatctgacg gcgcgtccgg gtgccgccaa gacgcaacat 3641581 gatggcctgt acctgctaaa aataccccta atttgatttg tttctttttg cttgtcatgg 3641641 cgatactcct tttatcatgt ttttaggctg aataatccga aaaataaact cctatattcc 3641701 tagtcgttta atatgaataa atcaaaatgt acctttgtct tggacgtttg tcaatgagtt 3641761 aagattaatt ttttctattc aagcgaaaag acccttgcgt gaccatgagg gaacggcatt 3641821 gattcattca actagtgcaa cctctatatc ggcaagaaaa ctgagtctaa tgaagcaaag 3641881 actcagtttt cttccaataa tttcatataa gatttcgcca tttcctttgc cttttcttcg 3641941 cttttgcaaa ccgcctatcc attcagacgc cgtaacgatt gtataaaaaa acagctgact 3642001 ccagatattc aaaccggaat cagctgattg atgtgaatta attaagctca tgaatactct 3642061 cttctgcttt agcggaaaac actttaggct ccaaacagtc aaggtcttca tgaaataaat 3642121 ttactttttg gatttgccga ttgtcatagt ggtggaaata gtagtttcca gtttcgttgc 3642181 acatcacgga agtatattgc gtataatgaa tttcgtcttc ttccgttatc actgcgccct 3642241 ttggtatcgt catatttgcc aaaatttgaa aagcggctgt tacacctttc gtttcatcgg 3642301 ccgccggctc tagatgttct ttcaaataaa cagctctgac aaaccgggaa ggcggtgtat 3642361 aatcccccgg cagaccaaca gttcctaagc cttggccaaa agcagaaagg gctaatccgc 3642421 ccatctcttt gctctctaat tgcttcggtc tgattcctgt atattgctgc agattggtta 3642481 catgccatat aaagtcgggg ctgttcgtca tgacaccagg ttgattatca tagactttga 3642541 ggccgtctgc tcttggttct atcgtcaggt ttcggcccgt ccggtctgac aatatccagt 3642601 gaagcggtaa aactgtatcc aatagatcta attttttctc tacaatcgtt aaagatcgaa 3642661 tcttttcttt tacgtcttcc aaagactgac agactgacag cacccatgtc acaaactcat 3642721 gcgggacaat gtgaacggta tcttcccgta tcgttttttc gtactccgca tagcccggaa 3642781 aataaagcgc cgcacaagat aaaccgcttt cattaatgcc gtcggcaaat aatatatttc 3642841 caagttttct ccccataccg ataaacgcgt actgtgtctg atgggccctt ccgtcagctt 3642901 cactgttcca gctgtaacgg cgcggataga gaatcacctc tgtccccagc tgaaatgcaa 3642961 aatccattgt tcttgctaat acatgtttac ggtcagcagt ttccaatgta agacttgtgc 3643021 acatttgatc agtccccttt tcaattcaga ttaatatcat acatattgtg aacgaattgg 3643081 ttttatcagc ataacgaaag tcaaatcgat tcgtcaaaga attgacatta catcaaataa 3643141 aacgaaaaaa tccagccttt agaaggctgg attttttatt atttagccaa aacaagctcg 3643201 tgaatcgcat gtgcaacgcc atgttcatta ttggagcgtg tttgaaagtt tgctgcttcc 3643261 aatacttctg ggatggcgtt tgccatggca accccgcagc ccgcccattc gatcattgtc 3643321 aggtcgttcc cgttgtcgcc tatgcacatg acttccgcct gttcaattcc aagcagctga 3643381 gccagctggc gtacagcatt tcctttgctg gcttccgagt gcagaatttc ataaaagaaa 3643441 ggcgcgcttc tgaccattgt atatttttct ctcacgtctt ttggaatcga tgtaatgacg 3643501 cggcttaagt tctccggttt atcaataaac atcactttcg ggatgaggat atcttttggc 3643561 acctcgtcaa tcttgcggaa atgaagcggc acctgtgtca cataggattc gtatacggta 3643621 aattcgctaa tatcccggtt aggcgtatac aaattagatg agtcaaagaa atgcatcggc 3643681 gtcttcagct ctaagctcag gtcatataat gaagtcaaat catcataacc gagagacagc 3643741 tctgagacca cttcatttgt atgcgtattt tgaacaagtg ctccattata cgcaataaca 3643801 tagtcgcctt cttcaattaa attcagttca tctaaatatc tctgcacacc cccgataggc 3643861 cggccggtgc aaagcacaat tttgacacct tccgcttttg ccgcgtgaag ggcgtcgcgg 3643921 acctcctctg ttacttcatg atgatcattt aaaagtgttc catccatatc aattgcaatt 3643981 agtttgtaca tcctgcatct ccttcatgtc gttttcaggc tatagtccca tcatatcgtt 3644041 ttttcttttt gatattcaac cggaagagat ggttttctcc ggattctgtt tagacgccgc 3644101 ccttgtcttc ggatacgcaa gcgcggtttc cgctttcttt ctgccttgac gccgttttct 3644161 gcttttttct gtttcatcag cagaaagccg gcagctagaa aaggaatgcc ggttatattc 3644221 aagatggcaa gcttcacacc cgccgcgatg aaaaagaacc cccatgaaga tgatggattc 3644281 cgtctgatca tgacgtaagc cgccatttcc agaacgatca ggatggcatg aagcactatg 3644341 ccataaatca gcaatacaag ggcaaaaaac aaaacataat tcacgattgc ccctgagtac 3644401 atcatagcgc gcatcatttg tataaacgat aaggactgca tggagccgct gatgacatta 3644461 gggttataga tcgtatagtc actaaataaa tgtttgactt tgagaaaagc ccataatata 3644521 aatatccatt gaatgatatg taaaacaagc cccgctgcca ccagtctttc agctttttga 3644581 tttctcatct ttctcctccc tgccggtctt tgattcgatt cttgtcatcg tttttctctg 3644641 tccattttgc tcccatatca atgtcccgtt ttctcctctt ttcagcgtgc ttttgagcgg 3644701 ataataaggg ccgaggtact gaatctcgat agacccgtca gtgctttggg aaatcacctt 3644761 gtatgccata aaaggcagct gtacctctcc tcttccttcc atcacttccg tttccacaac 3644821 ctcgtcttcg gtaaatgtga ctgttgctga tttcacaccg tccgttggcc cgggggcacg 3644881 cccctcatcc cacgttccgt aataaaacgg cgtctcttct ttttgctgct ggcagcccga 3644941 taccatgatg catacagcaa ttaaaaacaa aatgccatat ttgtttctca aggggatcac 3645001 cattctttcc tccttttttg ggcgaatgcc gtgccactgt gccaatgact acataagtta 3645061 taaggaattc acccacaagg agactgatca catgaaccct tatcaatatt acagccctca 3645121 gctgcctcag caggaacctt actatagcca ctatgagtac aatccttatc cgcagcagga 3645181 tgtatacgat ccataccaaa tggacagaca gccggcattg gaaagaagaa tcgcagcact 3645241 tgaacggcaa aatgaacagc agtcaagaga attaacccgt ctgacaaacg aagaccgccg 3645301 tcaaaatcgg gaaattgcac ggattgccga acaggtcaat cagttaagcc aggctgttga 3645361 acgccataca cgccgcctaa atcggctcaa tcagcgcctc cgtacagtag aaaaccggct 3645421 gaatatccca tttactgcag gggaaggcgg tttctgagcg aaacaaagaa aaaaagcgga 3645481 atacgattct cccatctcag ggtttcgttt tccgcatttc ttatatgtta aaacggaaca 3645541 tttacataaa aagggtttgt acccagtata caatctttac cgttttcatt caaagataga 3645601 ggggctgagg aaaataattg tagttcctct ttgacggaat ttcttttcat tcaagttgca 3645661 tgataatacc gactcacgtc aatcgataca tggagggatc attcatgcat aatacacaac 3645721 acggcttgca gcagctgaac caatgccgcc aaactgctca gcagctcatt cagcaaacac 3645781 agcaaagcag ccagcaatat cgccaaatgc ttcatcagga acagcaaaac atccaaatgc 3645841 tgcagcagat tctaaaccac gaacaacaag ctgcacatac cattcagcaa gcactgcacg 3645901 ggcatgacat ggcgattcaa aagtgccagc aggttgtcaa catgtgcaac caaatgcaac 3645961 aggaacttac tggacaatcc agcgtcatga atacgaatgt gtctacactt ccattcggcc 3646021 aaaacacgac atttcagcag caatcctacc agcagtaaca tataaaaagc tcaacacaat 3646081 gcgagtgttg agcttttttt cttactgttc tttgcgaata tgtatatcct gaatagactg 3646141 tttcggtgca tgaaatctgc tctcggcttc acttcttgcc tcggcaaaag cccgcgcctc 3646201 cacatgatct ttgtagacat ccagctgaat caaatacagc gggcgcactt taaatccatg 3646261 aataatggtt accgcccata acgggaccac aataaaaaca ccgggcagat cgggcaaaac 3646321 aaaaccaaac gcaaaaatga aaaaataaat gatgccgtac atgatccact ttctatttct 3646381 aaccttgatg ccaataaata aaaaggcaaa aaaactggta atggcaaaag gcatgaaaat 3646441 aaacagcatc caccagctat gcagccattc ccaagcggca cctctttttg taattcccat 3646501 atttttctcc tcctatttac ctataataat cgattaggca caccgcgtca cccataaacg 3646561 ggaaaaactt tctcccttaa aaatagtgat agacggagaa caggtttctt gctatattat 3646621 taattgataa tgataatcat tactaatcta ttgagataca tagtgggagg gttcttgatg 3646681 aaaaagaaca tattgctcgt gggcatgctt gtgctgcttc tcatgtttgt cagcgcttgc 3646741 agcggcacgg cttctaaagg gagctcaagc gattctgctt ccgaaaaaac agaaatgaga 3646801 acatacaaat caccaaaagg gaacgtcaac attcctgcac atccgaaacg catcgtcact 3646861 gatttttatg ccggtgaatt gctgtctgtc ggggccaatg tggtcggctc aggctcatgg 3646921 tcatttgata atccgttttt aaaatcaaag ctgaaaaatg tgaaggatgt tggtgatcca 3646981 ataagcgttg aaaaagtgat ggagcttcag cctgacttaa ttgttgtcat gaatgaagag 3647041 aatgttgata aattaaagaa aatcgctccg actgttgtca taccttataa cacagcgaaa 3647101 aacgtagaag acacagtcag catgttcgga gatatcgccg gagcgaaaga ccaagcaaaa 3647161 tcctttatgg ctgactttaa caaaaaagcg gaagcagcta agaagaaaat tgccggcgtc 3647221 atcgacaaag atgcaacctt cggcatttat gaaaacacag acaagggcga attctgggtg 3647281 ttcaatgaca atggcggacg cggcggccaa gctgtataca atgcacttgg gttaaaagcg 3647341 cctgaaaaaa ttgagcaaga tgtcatcaaa aaaggagaga tgaaacagct ctctcaagag 3647401 gttattcctg agtatgccgc agattatatg ttcattacgg attacaaccc gaaaggcgaa 3647461 agcaaaacac tcgacaagct ggagaattcc tccatttgga aaaatcttga cgctgttaaa 3647521 cataatcgcg tgtttatcaa tgactttgac tcgttctacc cgtacgaccc gatttctgtc 3647581 agcaaacagg tggatatcat caccgacatg ctgatcaaac gggccgaaga aaataaaaaa 3647641 taaaaaaacg gcacagtcat gacgctgtgc cgttttttat gattcacttt aattttgact 3647701 gtacggagtc cggcatatct tcaaacttga cttcttccca agtctcgaca tactttcctt 3647761 tcgccttcac cttcaaatac gcgttcttcc gaagctcttt gccggcgaaa aaggtcactt 3647821 cttctttttt cccggatgca ttatatccgt ctaatgtata ttcagtaccg cccggactaa 3647881 gatgtctgcc atctcgatca atctgaacat agacatcttg ctggtgaata aacggattaa 3647941 atctgtctgt aacatcgtta tgaaaaaaga gaagcccgca tattacggca gcagccgcca 3648001 agacggccag gattgccatt gcttttttca tctttgcact ccccttactt gttcattttt 3648061 ttcaaatagc ttgaccgcac cgcgaggaag aatagaagct gaaaaatgaa aaaccctccg 3648121 atggtgagac tgagcggccc cgctacatcg gaatatcctt ccacagccaa tgttctcaag 3648181 gcaaacagtg tatgcatgac ggcaatgaca aatggaaaga agaaaagaat cgccaattgt 3648241 attgtcacgc tttgcgccat ttctcgctca ctcaggccga ttttggccag tgaacggtag 3648301 cgctcccggt cttcatctaa atcagtgaac agcctgaaat ataagaaact tgctgccgcg 3648361 acaaagaata caattgcgat aaacaggccg ataaatagac tcaggctcgg cagctgcacc 3648421 gtatcatagt aagtccccgc ttttgaagca aaatcagaat gcacgtcgat ataattgccg 3648481 taaatctcat tttgcaagga ttggctgatc tcaagactgt ctttccaatg atcatagctg 3648541 tagccgtata atgacgcttt atcaccgagt gatttcagct gatcaaaggt ttgatcattc 3648601 accgcgatga tagcattcaa tgagatcagc ggttttttga cttcttttac cgacagtttt 3648661 tgatcagaca gctccccttt ttggttcagc agcttcagct gatccggcgc ttcgtttttg 3648721 aaattgcggt catacgttcc cgggaaatag acagcctcgt cttctttcag gccgttcact 3648781 ttgacatgga agtattttgc cgcatccgat tcactgatca tgtaaacagg gggaacagtt 3648841 tctccttcct gatagcgaac ataggaaaca tctattttgt ctttcgtata cgtaaaaccg 3648901 tgtgttttca gttcatggtc aatatctttc aaatgagtct gttcttttgg attgttgctg 3648961 taagataaat actccatttc ataagcggac tcttccgctc cgacggtcga tttgtacatt 3649021 gcgagcacgc ctgtcgcagt aaacgcaacc gcggaaataa tgctgacaat aaagaacagg 3649081 cgggcgttgt cttttagacg atagacaagg tcagaaaccc aaatgatgtt tttcccgcgc 3649141 agataaaagg ttttccactt cttcagcgcg cgcagaatcc atatgctgct ttggctgaaa 3649201 aagaaatatg ttccgataac ggtgagcagt aaaatgataa acggttcggc cccgtggaca 3649261 ttgcctttaa gaaccatgcc gtacccgccg cacagacagg cgatgccgaa taaggacaga 3649321 agcacggacg gcttaggctc cggtttaacc ttgccagtgc cctttattaa tttgataacc 3649381 gtatttgatc tgacaaaaag gatcgtaaac tgcgataaaa agaaaaataa gagcagaaat 3649441 ccgcaggccg taataccgag cgctttccaa ggcatataca aaggcagcgc gtccatttct 3649501 aaaatataag cgccgaccgt aaagaacgtc tttgaaaaaa tgaatcctcc gataataccg 3649561 gctgcaattg acatgacgcc gatgatcata ttttccgcag taatgagctt tctcagctgc 3649621 cccggcgtga tgccctgcat gagcagaatg ccgaattctt tatttctcga tttcaaaaat 3649681 gcattaaccg aatacagaac aaataagaaa gaaaaaacaa agatcatcca ttccgcggcg 3649741 gttaagcctt ttttggcgat gttattcagg tagccttcct ttaatgccgg atgaaacagg 3649801 aacatcgcaa aggtaaagaa aatcaaaacg gaaaaggcgc tgcttaaaaa gaatgcaaga 3649861 taggcccttt tgtttctcgt gacgttttta taagcgaact gaagaaaggt catttgcgtt 3649921 tccccccagc atagacagca catcgagaat ttgttcataa aatacttggc ggttttcccc 3649981 gcggtaaatc tcattaaaca gttcgccgtc ttttataaag atgacgcggc ggcagtagct 3650041 tgccgaaacc ggatcgtggg tcaccatcaa agccgtgaca tgatcatccc gattcaggct 3650101 ctgcaacgtt tccatgacgt cttttgtcgc tttggaatca aggtttccag ttggttcatc 3650161 ggccagaatg agtgacggct tatgaatgac cgctcttgcg atggcggccc gctggcgctg 3650221 gcctccggat acttcaaacg tccgcttgtt aagcaggttt tcgataccga gctttgccgc 3650281 gatgccgtgc agtttttctt ccattacaga cggcgcttct ttttcaagcg ttaacggcag 3650341 catgatattt tcaccgatcg tcagcgtatc cagaaggttg aaatcctgaa acacaaatcc 3650401 gagctgcttg cggcggaaat gagcgagctt tgtccgcttc aggcgatgcg ggttttctcc 3650461 gttaatcagg atatcgcctg aatctggacg gtcaatcgtt gaaatgatat tcaaaagcgt 3650521 tgtttttccg gacccggacg gccccatcac cgccgtgaac tcgccttctt ctattgaaaa 3650581 tgaaatttgc tttaaggcct gataggacac ttgtccttta taggttttat ttatatgttt 3650641 gacttcaagc atattcgcca tgaaaatcct ccttatggtt ttattcttgt tgatctgggc 3650701 tgctttcatg tagtgccggg acgttcaaca taaaaatccc cttgacataa atccatgtta 3650761 tcaaggggaa acaaagcggg ctatgttgtt ttcttaacgc agccttacat ttttgtaaga 3650821 aatgaaaatc gaactgatgt cccttcaccg ggagacgagc tgatgtccac cgtatgattg 3650881 agcttatctg taatttcttt gacgagatgg aggccgattc ccgtagattc ttggaaacgc 3650941 cgcccgtttt cacccgtgta ataagggtca aacacccgct tgatgtcttg tgagggaatc 3651001 ccgacaccgt aatctttgac ttcaagcacc gtcctgtctt catcgcagaa gacattcagc 3651061 tcaagtctgt cactcttgcc cgctgaatac ttgaccgcat ttgtgaccac ttggccaatc 3651121 gcaaatttga gccatttggc atcggtgtaa atctgatgat catcgcaaac gttcattttc 3651181 ggataaacgc gatattgaat aaaaaatcgt ttatagcttt gaataactga ttggagaagc 3651241 tcggacaggg aaaccgcttc gattttaaaa tcccgttcaa acaggtcgag ccttgaagaa 3651301 taaagaagcg tctccagccc gaattcaatc tgccggactt cttttttgat ttgttcaaaa 3651361 acgggctcat cctcttcttg aatgattaaa ttaatgaccg acagcggcgt ctttacttgg 3651421 tgcacccatt gattcatata cgtcacccgc gcgtcaagct tggcttcggt ctcatggagc 3651481 ttctggtgct gcagccggat cagctccatc tgcttttcat acagctctga acagaacact 3651541 gaagaaccga gatacgggat atccgtccct tcctgccccg agctgagcca atgatacacg 3651601 ccgcggtctt tgtaccagcg ataggcaaga tagcccgcca aaataagaag ctgcacgccc 3651661 aatatgtaaa acaagtgaga aaaagaatga agacccgcaa accagtaata aaagaagaca 3651721 aacagccctt gaaggagaaa aagcagaatc agcactgcat gagaccggag aaacagcttc 3651781 atgactgcgc cctcagctgg tagccttcgc cccgcaccgc ttcaatagaa acaggcgcat 3651841 tcagctcccg cagttttttt ctgagccgcg tgatatacac gttaagtgta ttatcatcga 3651901 tgaatatgtc ggtgtcccac gtcttttcca tgagacggtc ccgactcgtc accttttctc 3651961 cccgctcaag cagcacttcc aaaagcttgc tttctttttt agaaagctca cttttttcat 3652021 cctgaaaacg cagttcaaac cgttccacaa agagctgaac gccggcatat tcaaccactt 3652081 tctctccctg ctttgcggcg tactccccgt acgccctccg gatctggctt ttgattttcg 3652141 caagcacaat atcataagaa aacggttttt cgatataatc gtctccccca ttttcaatcg 3652201 ccatcacctg atccatttcc ccgcttctgg cagaaataaa gatgatcggg cttgtggagt 3652261 gctggcggat ctgccggcac caataatatc cgtcatatgc cggcaaattg atatcaagca 3652321 gcaccacatc gggcttttcc cgcaaaaaga catcaagaac agctgtaaaa tccgcggcga 3652381 ccactgtttg atatccgtat ttttcaaggt aattctgcaa tagtccgcga atgtcttcac 3652441 tgtcttccac aatcatgatt ttattcaaac tgaaccactc ccgtttctta cactgctgcc 3652501 atcatcataa tcgttttggg cgtatggacg caacaccgca caaaaaaacc gccatctcgg 3652561 cggtttctgg tctctttagc cgacctgctg cttagctgct ttaccggctg atccgaactc 3652621 tctcattttg cttcgcactg tctcttccac ggcttcaatg ccgggtgtca aatagccgcg 3652681 cggttcgtac agatcgctgt tttcctgaaa catgcggcgt gtttcgtctg tccacgctac 3652741 catacattcc gtattgatat tgatcttcgc gtggccgagc gtgatggctt ttttgatctg 3652801 atcctgcgga atcccggatg ccccgtgaag aacgagggga atatcagtca tgcgggagat 3652861 agcctccatt tccttaaatc cgagattcgg ctcaccctga tatttgccgt gtacagagcc 3652921 gagggcggcg gccagcgcgt cgatattggt ttctttaacg atccgctcac attccgtgat 3652981 atccgcatag cggaccccgc cgaccagtcc gtcttccatt ccgccgaccg tgccgacttc 3653041 ggcttctact gacacgccgt gttttgcggc ataatcggtg acttcttttg tcatcgcgat 3653101 attctcgtca atcggctgat gggagccgtc aatcatcact gagctgaatc cggcatcaat 3653161 ggcctgtctg cagcgttccg cactgctgcc gtgatcgaga tgaagcacga ccggaacggt 3653221 aatcgccatg tcctctatta acgcgccgac catggcggca atcgttttaa atccgcctaa 3653281 atagtcgacc aggcgatcgg aagccgcggc gatgaccggt gattgctcct tttgcgccgc 3653341 ctgcaaaatc gccttcgtcc attgcaggcc gttgatatta aactggccaa ttgcatattg 3653401 ctcccgcttt gcatcttcaa gaagctcttt catcgataca aaagccatat tcacccctcc 3653461 tttatccatt acatgctgaa gtattttgat acgacatcca ctgttgtttt tttcgctgtt 3653521 tgaatggctt cctcagcagt cagcttatag tattcaggcc ggaagagctc aaccgaaaca 3653581 acatcagaga agccgatttc cttcagtgct gataagtggg catctaagtc aattgcccct 3653641 tgtcccggcc atacacgatc ctcatctgtt aaaaagccga ttgggaaatc ttctgtatca 3653701 tcaatatgat agatgaagat tttctttccg tccgcctgct ttaagctctc aatatttgaa 3653761 cccattgcat ggaagtgaaa actgtcaagg acaagcccga cattgtcacg gttaactgtg 3653821 tttacaatct catacgcctg ttcaaacgta ttgaccgtac attgcggatg gccgacaaac 3653881 tcaagcgcga tttttacgcc gtacggctcc gcgatatctg acagctcagt cagcacgtct 3653941 acactgctct ttttgatctc ttcttttaca atcttctgct ctgtcacaag cggaacggcc 3654001 accacatatt tcacaccgag ggttttgcat gtttccatca tgcctttaaa ttcagtgatg 3654061 atctcgttgt gacccttttc atcacggttg ttgaagaaaa cgagtgcgtt taaggcaagc 3654121 ggtttgatgt ggtgggtttg aaaatattcc gcaaggtcat ccaatgaatg atcttttaag 3654181 tactccggca gcttatccat agtacggatt tcaatataat catagccatg cttttcgcat 3654241 agttctaaat ccagtttaag gtttgagttt tccaatgttg tcgcttcatt aaaacaaagt 3654301 ttcatgccag actcccccat ctgcgtttta gatatgaagg gagttcggca ggaaggctgt 3654361 cgccatatcc cgccgaactc catgctcagc ttatgccaga cctaattctt ctttcatttt 3654421 cttaagcata aatcggcttg attcatccgc tctttcatcg acccaagcaa atacggcatt 3654481 cgtcgcaatt ccgtcgaact tcatctctct cagttttctg aaaatcgtat caaaatcaac 3654541 ctcgccttgg ccaatgtcca aatgctggtg aaccgttact ttcgcgtcag gcggattgac 3654601 gatgtagcga aggccatgag ccgctttatg attataggta tctgcaaata aaacatgtgt 3654661 gaggcggtcg ccggcttcgt caaacatggt ctcgatgtcg cctttgccgt catcatagaa 3654721 gaacgtatgc gcagtcgagt agacaagatt gatccaatcc ttgtcaagcg cgcggatcat 3654781 atccatcgca cctttgtgcg tttcgataaa atcatatgga tgggcttgaa gattgagttt 3654841 aatgccttct ttttcaaaga ctggcagaag ctcatccatg gatttgataa atttttcttc 3654901 acttgttaaa ggatcatatt ttgaaccgct gaattcgctg ttcatcaaat ccacttcaag 3654961 ttcaaccgca atttcgattg cccgtttcca gttgcgcact gctgcctggc ggcggtcttc 3655021 atcgggtccc gcccagtggt aaagaggaag aagcgatgaa agcttaacac ctgtatctct 3655081 taaaaggcgc tttaattgtt tgatctttgc tgaatcgact ttcggatatt tataaaacgg 3655141 gcaaaaatcc tcgcgcggcg ataattcgat atattcatag ccgagctctg ccgttttata 3655201 gaccatttcc tctaaagtta aatcatcacg atacatggat ggatccaatg ctaacttcat 3655261 attttcactc ctctgttttt tagttttgaa ctgttgtaaa agattgatag aattccggtt 3655321 tttccttcaa ttcaaccttt tctttttgtc cagattcctg ggcttttaca cacgcgtcag 3655381 tcgtgacagc agcaatatag ccgtcccatg ccgtcggtcc gctgacctcg cctttctttt 3655441 gaatcgaatc aataaagtct tggatttcca catcatacgc agcgacaaag cgtctctgcc 3655501 aatccatcaa aatatcagtg ctgaatctgc cttcttttct caagctgatg cttgatggct 3655561 cgggaagctt gatgatgccg tcttctccga cgatttcaca ttgaatgtca tagccgtatt 3655621 tacagttcac atagatttca gcattgatga cgataccgcc ttttgtttca atcacgacga 3655681 tttgcggatc ttttaaatgt ggaagcgcgt tttttgattt tttcggatag atgacttgaa 3655741 cggactcgta gtcatcattg acgagccagt ggagcacgtc aatttcatga acaagcgtgt 3655801 cgactacagc catatccgtt gtatagttat ctcctacagt cgggttgcgg tgcgcgcagt 3655861 gaatcataag aggctcgccg atgacatgat tatcgagcgc ttctttcagc tgtacgtaac 3655921 cgctgtcata acggcgcatg aagccgactt gaacaaggcg tttgcccact ttgatttctt 3655981 cttcgacaat gcgcatgcat ccttcagccg ttgtcgcgag cggtttttca cagaacacat 3656041 atttctgggc tttaatcgct ttcagcacgc ttgactcatg cgcaggcccc cagcttgtca 3656101 ctaaaacagc gtctacattt tcgtctgcaa gcaagctgtc atcattcgga taaaccgtcg 3656161 cgtttaattg gtattgctca acgacctttt gtgcagcttc ttgattaaca tccgttacag 3656221 ctacaatttc cgcgcctgac agcttgttcg tgatacggtt aatatgttct tttccgattg 3656281 ctccagttcc aattacgcca atacgtaaac tcattgacag ccactccttc tgttggttac 3656341 atgattttgc tttctgttcc tttctttact tggctctgag gagacccgta gagttcctct 3656401 tgaatttgtt caagcgactt gccagacgta ttcggcgcaa agagcagccc gatgatcata 3656461 ctggccgtca cacatccgag aagaattgca gccatcgttc caatgccgaa attggtgata 3656521 atcattggga caaacagact ccaaatccct attgaaatac ggacaaggaa aaacatcagt 3656581 ccttgtgcgg aagcacgata ttgcgtagga aagatttcgc tggcccataa ctgatagttc 3656641 gcttgctgcc cggctccgtt attgatgccg atcacgacaa taaacaggag cagaatcggc 3656701 aggccttcaa ctggcagcag aaacagtgtc cacccgatca ccgccatgaa agcggcgatt 3656761 ccaaatacgg tttttctata tttgtcggca aagggcatga agatcaaggc gacccccaat 3656821 cctgtgaaga taaacagccc catttgcaaa aggttggcca tgttggcaga tacaccgccg 3656881 acctgctgat aaatgtatgg cataaagaag cccatgaccc cggcggctag gttccaaacc 3656941 aagtacacac ccatcaaaaa caggatgctt tttagataca taggcttgag caaatcaaaa 3657001 tacgatgtct tattcaatac agccggcttc tctgcctgag cttcctccgg ctgatttttt 3657061 gtctgccagg cgtctgattc cggaagcctg attctcagga tgtacgtaat cagcgcaatc 3657121 acaagcagat gggcaaatac gattttattc cccaagagtc ccaagtcacc ggccagtacg 3657181 gagaggagca gtacaacgac agcgcccgcg gcccaagcga cttgtgctac gccgcaatgc 3657241 ctggcccgat tcttctttgg cgcattttcc gcaataatgg tccatgacgc ggttatgtca 3657301 gcccctactg ataaaccgat aatgatgtaa ccgcttaaca acatggggaa attaaccccg 3657361 aacaaaacca aacaaatccc tagtgcataa accagcatac tattggtata aacagccttc 3657421 cgtccgactt tatcagccag aaacccgcca agcagcgcgc cgacagcggc agaaatcgca 3657481 tttgcgctca acgcgccgag cagcccgatt tgcgtatcgg atagcttaag gtaactgacc 3657541 cataatgata aaccggcgga gcctgccaca attgaaccgg catcaatata gttggccaat 3657601 gctgccgcga ttgtccgttt attgaaggct gaatctccat tggtattgcc catatgttca 3657661 ttccccatta agccagatcc aacaactgct gatcaatata gtttctcgca atcaatgcat 3657721 actccagcgg gtttgcaaca tcggggtctt gttcagcttc aatgacaatc catccggaat 3657781 aactgtgctt caacagcagc tgatatactt ctctaaagtc aatgcagccg tcaccgggaa 3657841 ccgtaaacat gccttttaaa aatgattgcc ggaacgattg tccttcgagc ctgcattgtt 3657901 ccatgacatt caggcgggca tccttaaagt gcacatgctt aatgcggccg atatgcttct 3657961 caagcatccc catgtaatcg ccgtcagaaa tatacgcatg gcctgtatca tagaggaggt 3658021 gtacatgcgc agggtctgtt cctgccatca ggcggtccac ttcttccgct gtttggacac 3658081 cagtgccgag atgatgatga tagacaagct tcaagccatg ctgagcggca atttcgccaa 3658141 ggtgattcag cccttcgcaa agccgctccc attcatcatc cgtaaagtgc ggcttctctg 3658201 tgaacacatt tttctccaag ctttgcacgc tgtacgtttg ttcagagaca actgcgacat 3658261 ccgcgtttac ttgctgcaaa tactcacaat gcagggtaaa tgtctttgcc gcttcaccaa 3658321 gtccgtcacg caaaataaaa ctgctgaacc attttcctgc aatgcgtaag ttccgaagct 3658381 tcagctcttt gttcaggatg gcaggttcgg ggaaaaagcc cccgacctcc gtgccttgaa 3658441 aacgtgcgac aacgatatca cttaacaaat gctgaagtgt atttcccgct ccaatttcag 3658501 gcatgtcatc attccgccac ccaatgggag cgattcccca caggatttca tttttgccca 3658561 tctatggtgc ctcccctcta atactgcttc gcagattcca gctttttctc ttttgcttcg 3658621 tatgctttct gaacgctttc ttgttcagat acctctgcca ccccgacatg ccaccagctg 3658681 tcatagccgt ccgtcattgt tttaggcagc accttcattt caattaatgt tgatacatcc 3658741 tgtttcttcg catcctctaa cgcagctttt aattcttcta ctgtgtttgc acggtaggtt 3658801 ttcgcgccgt atccctcagc gactttcgcg taatcgacat tcaggatttg gttgtcatct 3658861 gtgcggaact cgcaatagta gctgccgctg ccgtgatcca tttgcaggtt gttgatgcat 3658921 ccgaatcctg agttgtcaaa gagcagcaca ttgattttct tgttgtactg aatcgccgtg 3658981 atcagttcag aatgaagcat caggaagctg ccgtctccga cgattgaata cacttctctg 3659041 tcagggtggg ccagtttaag accgagtgtc ccggacactt catagcccat gcaagaatat 3659101 ccatactcca ggtgatacgt attcggaaca ttagaatgcc acagacgctg caaatctcct 3659161 gggagtgagc ctgctgaaca gatgatgacg ctgtcttcag gaatcgtctc gttgattgtc 3659221 agcaatgccg ttgtttgcgg aagctccgta ttcaacgcgt cagcatattc attcaggacc 3659281 tcttgagaaa agtgattttt gatttccgga tcaaatgctt cccgcttaaa cgtcactttg 3659341 ctgagacgct cgcgttcagc tagccattcg tccttcagct cccggatcgt tgtgccgaac 3659401 tcgctctcat agccttcaag caagccgtgc agtttgccaa gcgtcacttt cgcatccgcc 3659461 accacttgga atgcatcaag tttatacgcc tgcattcggc tgacgttaat gttcaaaaac 3659521 ttcgctttat caaaatcaaa agcggtctta gaggatgtcg caaaatctgt ataccttgtg 3659581 ccgatgccga taatcaaatc agcttggcgg gccgctttgt ttgccgcaag tgtacctgtg 3659641 atgcccattc cgccaaggtt gttcgcaaaa tctgcctcaa cggtagactt tcctgcctgc 3659701 gtttcaacta acggaatgtt ataggcttca gaaatggcaa ccaattcatc gcgcgcaccg 3659761 gaatattttg cgcctccgcc gacgagaatc acaggttttt tgctggattt aatcagctcc 3659821 gccgcacctt gaagctcgcg ctcgctcggc tgcatgcgat caatatagtg aacccgtttg 3659881 acgaagaaac tttcatcaaa atcgtatgct tccccttcaa catcctgaga aatacaaatc 3659941 gttgccggac ctgcttttgc cggatcagtc atgacttcaa acgcgcgcag caaactgctc 3660001 atcagctgct cagggcgcgt aatgcggtcc cagtatctcg atacaggctt caatgcatcg 3660061 tttgtcgtaa tcgccgcact gtattcttgc tccatttgct gcagtacagg gtctggctgt 3660121 cttgtcgcaa atgtgtctgc cggaatcaag agaactggga tattatttgc caatgcagtg 3660181 ccggctgccg ccaccaagtt agccgctcca ggtccgacgg atgtagacac cgcatatatt 3660241 tttcttctca gcatttgctt gctgtacgcc atggccgcat gcgccattcc ttgttcattt 3660301 ttcccttgat agactttcaa atggcctgca tcctgctcaa gcgcctgccc gatccctaat 3660361 acgtttccat gaccgaaaat cgtgaagatc ccttcgacaa aaggctcttc ctttccatct 3660421 acatggatgt actgctggtt taagaattta atcagcgcct gcgcagttgt taagcgaatt 3660481 ttcttaccca caaacgatcc cacctttact cgatcttttt caattatgac tgtgcttcaa 3660541 taagctgttc gatttcttcc gcagtcggca tcgcttctga cgaactgtgc ttgctcacca 3660601 caatggaggc tgaagcactg ccgtatttca atgccgtttc aatgtctttt ccgctgacaa 3660661 ggccatagat aaaggctgac gcataggagt caccggcccc aaaggttttc agcacttttg 3660721 tcttgtacgc ttgagcgcgg aatacctcgc cggatttgct gtatgcgtaa gagccttcga 3660781 cgccgtgttt gatgacaacg aggtcggctg aatggccaaa taaatgattg acggattctt 3660841 cattgcttcc gcctgtgcgg ttttccatca catcaaattc atcgcgtgtg ccgatgacga 3660901 tatcagactg ctcggcaacc aaagaataat aaacggctgt ttcatctgat gactgccacg 3660961 tatatggccg gtaatccagt tcgaatacca ccttaacctg atgctttttc gcgtattgaa 3661021 cagcttttaa caccgcttcc cgtgacgggc ttttggcgag cgctgtcccg gagacaagca 3661081 gcattttcgc atttgcgata tagtcctcac ttacctctga aggctcaaga taaagatccg 3661141 ccacatcatc gcgatacatt aagatgctgc attcttcagg gctgaggatt tctgtaaatg 3661201 caaggcctgc tttgtgtcca tcttgatcaa caatcatctg tgtagtatcc acgccggtct 3661261 ttctcatata ggactctatg aatcttccat gctggtcatc cggaattttg ccgatgaagc 3661321 ccgcttttaa gccaagcttc gcgctgccga tcgcgatatt cgcaggtgaa ccgccgacat 3661381 atttcgaaaa tgtcatcgtt tcttccattg ggcggttgta ttcgactgcg ttcagatcaa 3661441 tacatgcccg gccgatggca acaatatcaa aagccttctc ttcattgaat gtatacttca 3661501 tcgtaaacag ccactcctca cttgttagcg ttctaaaatc cattcatgcg ccgggtcgtt 3661561 ataaaacttc cattttcgcg tcggccctgc catgacattt aaatagtagg atgtgtatcc 3661621 gtccggaacg cctaccgggt ggtatcccgc aggaacgatg acaacgtttt catttcccac 3661681 agtcattgtc tcgtcaatag aacggtcatc tgtgtatacg cgctgaaaca caaagccctg 3661741 tcccgggtct aactcatggt agtacgtttc ttctaagaaa gattcttccg gcaagttgtc 3661801 ttggtcatgt ttgtgaggcg ggtagctgga ccagttgccg ctgtctgtat agacttcaac 3661861 tactaataga ctgttagctg aagggtctga atccggaaga atgttatgaa cagtacgttt 3661921 gtttgaaaat tgcccgcgat gctcaattcc gttgtcttcc gctttgatca gctttgtcgg 3661981 aagctgcttt tccgatggag aatagcaaag cgccactctt gcgtcgctga ccgctgtgat 3662041 ctcaaatgca cggtcatttg aaatatagac gctgtctgtc ggttttcgtt caaatacgct 3662101 ttcgcgcgtg ccgatattct caaaagtcga ctcatgatct gtcactgtaa ttttccccgt 3662161 taccgccaca atacagattt cttgtttttt caattcttct gtatagcttg aacctgatgc 3662221 aagatctaac actttaaact ctacataagt gagatcagag ttggatgtcg ttacttcgtg 3662281 cacgagtttg accccattag acacttcatg cgactgcggc ttacgcaaca aataactcat 3662341 agagaagccc tcctctttct attggcagaa tgagtccgaa cagcgcacat ggacgccgtt 3662401 cggctgttcg tcgtttagtt gaaatcaggt gccggatatc ttgccgtcac cactttttta 3662461 cgtgtataga agtcgacgct gtcttttccg ttcgcatgca gcgttccaaa gaatgaagat 3662521 ttccagcctg agaatgggaa gaacgccatt ggagccggca caccaaggtt gatgcctagc 3662581 attcccgcat caatgttttc acggaagtag cggattgcgt ttgagttgga tgtgaacaag 3662641 caggcgccgt tcgcaaactc agacttattg gcgatttcaa tcgcttcttt caggtttttc 3662701 acacggatga cagataagac cggagcgaaa atttcatctt tccagatcgt catttctgtt 3662761 gtgacattgt caaagatcgt cgggccgaca aagtagccgt cgtcagacac attttcacgt 3662821 ccgtcacata cgagtctggc accttcttca agaccttttt cgatatagct gagcgtgcgc 3662881 ttcttgttgt cttcgcgaat caccggtcct aagaacacgc cgtcatcaag gccgttaccg 3662941 attttaatgt ccgccacttt ttcctgcagc ttcgccataa attcatcggc gattccttct 3663001 tcaactgtca caaccgcaca agccatgcag cgttcaccgg cagaaccgaa ggcagctcca 3663061 acgatgtttg taaccgtgtc ttcaagattc gcatcgttca agacaatcgt atggtttttc 3663121 gcgccagtca gagattgaac gcgttttaag ttttcgcttc cttttttgta gacgtattcg 3663181 cctactggct tggagcctac aaatgaaatc gctttaattt cgggatgctc gaggatgccg 3663241 ttcacaacgt catgcgcacc gtatacgacg ttgaacaccc ctttcggaag gcccgctttt 3663301 tcaaaaagct caaccaattt ctctgttaac agcggagtcc gctcagatgg ctttaaaata 3663361 aatgtgttgc cgagcgcgat cgccatcggg aacatccagc aaggaaccat catcgggaag 3663421 ttgaatggcg cgattccgcc gacaactccg attgggtaac ggtagttcgc cgcttcaacg 3663481 tccgttgcga tggaagcaag tgagtcaccc atcatcaggg aaggtgctcc agcggcgaac 3663541 tctacgtttt caatcccgcg tcccacttca cctaaagctt ctttcgtgtt ttttccgttt 3663601 tcaatggtaa ttagatgagc aagttcttct ttatgctgag acagcagctg ctggaagtta 3663661 aatagaattc tggcgcggcg aggaaccgcc acctttgacc atgttttaaa tgcttcagcc 3663721 gctgtttgcg ctgcgtaatc aatatcctct tttgtagaaa tcggcacttg gcatagcact 3663781 tctttcgtcg ccggattgac gacatcttca tattgatctg ttttgctttc aacccattca 3663841 ccgttgatgt agttttttaa ttttctgatt tctgccattc ttattgcctc cttcattagt 3663901 aaacacatac acttgtatgg atggttccgg atagattcat atcaatatcc acttttcagc 3663961 aagccaagaa ttaaacgctt tcaaaaacac caaaaaaata aatggcggat gcatatttac 3664021 atacaagcaa ccatttcatg cacaacaggt tactttttgg tcatttcttg gttatattct 3664081 aatcgcataa tacccataag tcaatcataa acactacatt ttttcattat ttttattata 3664141 ttaatctttt aatcaagtaa gagaagtaag agaaggccgt ccaatcttgc aaaagatata 3664201 caccgatgtt atcattttta agcaactatt gattaacttt tggtttttat tatatattta 3664261 tgttacgtaa agattcaaga aggagttttt tatatgaaac tgatgcggat tcaggaaatg 3664321 gaggagtaca ttttatcgca tggcactgtt tccttagatg agctgtgcca ggtgttcaat 3664381 gtctccaaaa acacagtcag acgtgatatc aacaagctaa cagaaaaggg tgcgattgaa 3664441 aaagtatacg gcggcgtaac atctattgaa aaaaccgcat tagttccttt tgaaaatcgc 3664501 accattcagc accaggatga aaaaacaaaa atcgcccatt atgcttcccg atttattgaa 3664561 gatcacgatt tggtcttcat tgattcagga acgacgacaa agtctattct tgatacgctt 3664621 gatccagcca aaaatgtcac catcttaacc aacagtttag acattatcaa tgcggcgtca 3664681 gctttgaaga atatcaactt aatcattatc ggaaacaact ataagagaaa aacccgctcc 3664741 tttgtcggca tggacgaccc ggctatgctt gataagtaca atatcaacaa agcctttatg 3664801 tccgctaccg gaacgacgct gactcacgga ttgaccaatt cggatctgct ggagtatgaa 3664861 attaaaaaga ggatttcaga aaaagcaaaa gaagtgtatc tattggctga ccattctaaa 3664921 ttcggaaaat caacgcttct gacgtatgca ccgtttgaca ggctgcattg cattgtgacc 3664981 tctcagccat tagacgacga gtacacgcag tactgcaatg agcatcaaat cggcattcat 3665041 ctggcctaac gtttacaata gtgttgagag tctatcatcc attttattct aggaggcaga 3665101 tcatgaaaaa agcgaagctc ggaaaatcag acttgcaggt attccctatc ggattaggaa 3665161 caaatgctgt cggaggacat aacctctacc cgaacctaaa tgaagaaacc ggaaaagaat 3665221 tggtgcgcga ggcgatccgt aatggcgtga caatgttaga caccgcttac atttacggga 3665281 tcggccgttc cgaagaatta attggtgaag tgctgcgtga attcaaccgt gaagatgttg 3665341 tcatcgcgac aaaagccgct cacagaaaac aaggcaatga ctttgtcttt gataattcac 3665401 cagattttct taaaaaatca gttgatgaaa gcctgaagcg cttgaatacc gattatattg 3665461 atttgttcta cattcacttc cctgacgaac atacgcctaa ggatgaagcc gttaacgcgc 3665521 tgaatgagat gaagaaagcc ggaaaaatcc gttccatcgg tgtatccaac ttctctttag 3665581 agcaattgaa agaagcaaac aaagacggtt tggtagatgt attgcaaggc gaatacaacc 3665641 tgttaaaccg tgaagcggaa aaaacattct tcccgtatac gaaggagcat aatatttcat 3665701 ttatccctta cttccctctc gtatcaggtt tattggcagg aaagtataca gaagatacaa 3665761 cgttcccaga aggcgacctg cgaaacgaac aggaacactt caagggtgag cgtttcaaag 3665821 aaaatatcag aaaggtcaac aagcttgcgc cgattgccga aaaacacaac gtggatatcc 3665881 ctcacatcgt attggcctgg tatttagcaa gaccggaaat tgatatttta atcccaggag 3665941 caaaacgtgc cgatcagctg attgataaca tcaaaacagc tgacgtgacg ctttctcaag 3666001 aggatatttc atttattgat aagctgttcg cataagaaga aaacagcctt ctccaatgga 3666061 gaaggctgtt tttttgtgcg ataaattcct aaataactga ttttgaagca aaaccttaca 3666121 aaatgagcca taaatccgat aaaataaagg tagtttatct cagaaagaaa gtgattgaga 3666181 aagcaaaagt atgaaacgtt catatcatct agctcatatg aaataaagct gacccagctt 3666241 cttttatttg ctggtcagaa tagcggaccg tttcgatggt ctatggagga aacagaatga 3666301 aacttaaata tgtaaaagcc ttagttgcag taaccgttgc tttaggtgta ctgctgccat 3666361 caacgatttc tcatgcaaag agctttagcg gccgctcatc atctagttac agcagccgaa 3666421 gttcaagctc atcatacagc ggaagctata aatcaagccc gaaatcaagc tacagctcag 3666481 gatcaagctc ttctagcaaa aaatccaaga cgtctgacga ttcatcatca tcgatttcgc 3666541 ttaaaaagaa gccttcggaa aaggcaagtt catcaagctc taaaaaatcg tcaggcacct 3666601 tttccggcgc tacatcaaaa gtaaccggaa agacatacag cggaaaaacg tctaaagcct 3666661 atgttggcgg acgttatgtt tcagtcaatc attactatca cgcaggtttc gcgccatcag 3666721 gatggtttgg atattatagc ggatttacaa tgggtatgtt catgatcagc atgatgcacc 3666781 catggggtta cacctatcat ccagtcggag gccccggtta tgtttcttat ggcgcttcac 3666841 ccattgcctg gatcgttgat atcatcgctt tgattattat tttaatcatt gtcatcgcat 3666901 tgattcgcgc atttaaagca ccgaagacgt acagaaggag attttaggca atgagattaa 3666961 tattaaatga gcaagaaatt gtagacggaa tttgcgtgta tatttccaat gaagaagata 3667021 tctaccctga agacgttgaa gtaaaagaac tatcgtacaa caagcgtaca gggttcttcg 3667081 ctgaagctac atttggcctg caccacaagc agcttatgtc agatgacatt tcagaaggca 3667141 ttattcagtt cttagaggaa taccacaact tcaatccgga cgttaccgtc gttgaattgc 3667201 aatttgataa gaaaaaaggc ttctccgcct tggtttttgt caacgaagca gaagaataaa 3667261 aatgtcttaa tcaaacctta ctccgcgcgg gtaaggtttt tttaatggtt tctctgagca 3667321 taaagttatt tcgtttttcc taaactcagc ggatctgtga tcatctcttt tggctataaa 3667381 gtttccgttt tttcaaaaca aatgtttcaa atgagatagg aaatgggtac taatctatta 3667441 actttgttac atatttttag atactcattg gctcaacaac tgaggaggag acatttgtga 3667501 agaaagacac aaggaaatat atgatctact ttttcggcgc tttaggggga ctgctatatg 3667561 gttacgatac aggtgttatc tccggagcac tcctgtttat caataacgat attcctttaa 3667621 cgacattgac agaaggattg gttgtcagca tgctgctcct tggcgcgatt ttcggttctg 3667681 ccttgagcgg cacatgctca gaccgctggg gcaggagaaa ggttgtattt gtcctttcca 3667741 tcatttttat tatcggtgcg ctcgcttgcg cattttctca aacaatcggc atgctgattg 3667801 catctagggt gatactcggg ttggccgtcg gcggttcaac ggcacttgtg cccgtgtatc 3667861 tttccgaaat ggcaccgacg aaaattcgcg ggacactcgg cacaatgaac aacttaatga 3667921 ttgtcaccgg gattttgctc gcctatatcg ttaactacct gttcacaccg tttgaagcgt 3667981 ggcgctggat ggtcggtctg gctgcagtgc ctgccgtgct tctattaatc ggcatcgcct 3668041 tcatgccgga atcgccaaga tggctcgtga agcgcggcag cgaagaagaa gcgagacgca 3668101 tcatgaacat cactcatgac cccaaagaca tcgaaatgga attggcagag atgaagcaag 3668161 gggaagcgga gaaaaaagaa acgacacttg gcgtgctgaa agccaagtgg attcgcccta 3668221 tgcttctgat tggcgtcggc cttgccattt tccagcaggc agtcggcatt aacacggtca 3668281 tctactacgc gccaaccatt tttacgaagg ccggtcttgg cacatcagct tcggcgctcg 3668341 gcacaatggg aatcggcatc ctcaacgtca tcatgtgtat cactgccatg atcttaattg 3668401 accgtgtcgg ccgcaaaaaa cttctgatct ggggaagtgt cggcatcaca ctgagccttg 3668461 ctgctttatc aggcgtgctc ctgacactgg ggctttccgc atcaacagcg tggatgacag 3668521 tagtctttct cggtgtctat atcgtctttt accaggcgac atggggtccg gtagtgtggg 3668581 tgctcatgcc tgagctcttc ccgtccaaag cacgcggagc cgcgacaggg ttcacgactt 3668641 tggtgttatc ggcggctaac ctgatcgtgt cgcttgtctt cccgctgatg ctaagcgcga 3668701 tgggcatcgc atgggtcttt atggttttct cagtcatttg tcttctctca tttttcttcg 3668761 cgttctacat ggtaccggaa accaaaggga aaagcttgga ggaaattgaa gcaagcctga 3668821 aaaaacggtt taaaaagaag aaaagcaccc aaaaccaagt gctgaatgag cgtacattat 3668881 aaaaaaagga atcgtctcct tatgagacga ttcctttttc tgtttacacc atgaccttgc 3668941 aaatattgtt cgtaaattcc acagggtcct gaatcggcag gccttcgatg aggagcgcct 3669001 gattgtacag aaggtttgtg tacaggctca gcttctcttt atcttgttca aacgcgtcct 3669061 gcagtgtttg gaatacctcg tgatttgggt tgatttccag cactttttcc gccttcacat 3669121 tttggctgtc aggcatcgca tttaagattt tttccatctc aattgtcact tcgccgtcag 3669181 cagcaaggca gactggatgt gatttaagcc gttttgagat tctgacgttt ttcactttgt 3669241 ctgacagaat gtttttcatt tcctcaaaca gatccttata cttgctttcc tcttcctcgg 3669301 actgcttttg atcctcatcc gtgtctatgc caaggtctcc gcttgatacg gacttgaatt 3669361 ctttttcctg ataagaagcc agcattttaa ttgcaaactc atcgatgtcc tcagtaaagt 3669421 agaggatttc atagcctttg tccgccacca tttccgtttg cggcagtttc tcaatgcggt 3669481 cgtaagaatc accggtcgcg taataaatga atttctgctc ctctggcatt ctggaaacat 3669541 actcgtctaa gctgaccagt tttttctctt ttgaagagta gaataagagg agatccttca 3669601 attgatcctt attcgcgcca aaatcattgt acacgccgaa tttcagctgt ctgccgaacg 3669661 acttgtagaa cgtctcgtat ttctcgcggt cttttttcaa caggctttgc agctcgcttt 3669721 tgattttctt gctgatgttt ttcgcgatca gcttcagctg gcggtcatgc tgcagcattt 3669781 ctctggaaat attcagcgac agatcctcag aatcgaccat gcccttcaca aagctgaagt 3669841 ggtccggtag caggtctgcg cacttattca tgatcagcac gccattggaa tacagctcca 3669901 agcctttctc atattccttg gaatagtagt caaacggcat gttttcaggg acgaatagaa 3669961 tcgcgttgta gcgaaccgct ccatccacgc tgatatgaac gtgtgtcagc ggtttatcaa 3670021 acccgtaatg cttttcagca tagaattttt cataatcctc atctgtcagc tcgcttttgt 3670081 tttttctcca gatcggcacc atgctgttga ccgtctgctc ttcctgcacc tcttcaaatt 3670141 cattttcgct gccttccttc ggcttattaa tggttgtatc cattttgatc gggtagcgaa 3670201 tgaagtcgga gtacttcttg atgatcgctt ttaaacgata ttcctctaaa aactcgtcat 3670261 agctgtcatc ttctgtgttc tctttgattt tcaggataat gtctgtaccg acagaatcct 3670321 tttcacacgg ctcaatcgta tagccgtctg cacccgcaga ctcccattta taagcctctt 3670381 cgctgccaag cgctttactg atgactgtca cgacatcggc aaccataaat gccgcgtaaa 3670441 aaccgacacc gaactgcccg ataatgtcat gtccgtcttt cagctcgttt tcctttttaa 3670501 acgcgaggga accgcttttt gcaattgttc caagatgctg ttcaagctca tcctttgtca 3670561 ttccgatccc cgtatcagag atggttaatg ttctcgcatc tttgtcagct gcgaccttta 3670621 tgtagtaact gtctttatca aacgtaagcg catcgtccgt aagcgctttg taatagattt 3670681 tgtcaatcgc atcactcgaa ttggagatta actcgcgcag gaaaatttct ttttgggtat 3670741 aaatggagtt aatcatcata tccagcaagc gtttagactc tgctttaaac tcttttttcg 3670801 ccactcttga tcgctccttt accattatgt aaaccctttt cagcatctat ttatcacata 3670861 agatgacaat tgtcaattag attgatagat gcatatatat gtaaatttaa cattagttgg 3670921 atttgttttc actctttttc tcactcattc tcataaaaaa gagaggcttc atcatcctct 3670981 ctttttttct gtgtcattcc aacggccaaa ctcccgcttc atccatatat gcaccgggta 3671041 gaaaaacaaa ccgaacggta tcaaaaacaa aagattatgc catgaagcat tcagaaatgc 3671101 gcttgcagtc accgggaacg taatctcttg caataaaaaa gagatgacag tcagcacaac 3671161 aaatgcagat ggaatggtca cgatgcaata aaacttgagc tccttcttat gctgtacctt 3671221 caaacataca aacctcccaa caatttctaa ttcatcttaa catatgctgg cctttctttt 3671281 ctcgcatgtt tatcactgca catagcggga agacaaatag aaaaaggagg tctcgtatca 3671341 tgggaagact tgaaaacaaa acagcagtta tcacaggcgc cgcgacaggc attggtcaag 3671401 cgacggcgga ggtttttgcc aatgaaggcg cgcgtgtgat catcggagat atcaataaag 3671461 atcaaatgga agaaacagtt gacgcaatca gaaaaaacgg aggacaggcc gaatcctttc 3671521 acctcgatgt gtcagatgaa aacagtgtga aagcatttgc tgatcaaatc aaggatgcat 3671581 gcggaacgat tgatattctg tttaataatg ccggcgttga tcaggaaggc ggaaaggtgc 3671641 acgaatatcc ggttgacctg tttgaccgca ttatcgccgt cgacctgcgc ggcacattcc 3671701 tttgcagcaa atatttgatt ccgctcatgc tcgaaaatgg aggctccatc atcaacacct 3671761 cctccatgtc aggccgtgcc gcggaccttg accgctccgg ctacaacgcc gcaaaaggcg 3671821 gtatcaccaa cctgacaaag gcaatggcaa tcgactacgc acgaaacggc atccgcgtca 3671881 attccatttc accgggcacg atcgaaacac cgctgattga caaattagca ggcacaaaag 3671941 aacaggaaat gggcgaacaa ttccgcgaag ccaacaaatg gatcacgccg ctcggacgtc 3672001 ttggccagcc caaagaaatg gcaacagtgg cactgttcct cgcatcagac gacagctcat 3672061 acgtcacagg agaagacatc accgcagacg gcggcatcat ggcgtacaca tggcctggga 3672121 agatgctgat tgaggagaaa tggaaggaag aaacgaaata agagagggag ccccctctct 3672181 ttttgtcttt taaagcaata caaccttata tttcttcaca tccaaaaact gcaaaaactc 3672241 cctcgccagc acttcaggcg gatgcgcctt tccttcatcc agccgataca aaagcaaccc 3672301 gataatcatt gcggatacat aatgggcata aagctttttc tctgcgtgaa tatcagtttg 3672361 ctgatgcaga taaaacgatt ccagcgcttt gaacatatca ggtatcacat gaggaacacc 3672421 ccattcccga ttgagaaaat ggacaatggg catgtttgac aaagcagaaa gcagaatggc 3672481 gagcgccttc tccgcttcct ttaaggaaaa ttcattcggg ctggaggcaa tcgtcaggtg 3672541 atcaatgatc tccgcacatg atcgctgtat catggtttgg agcaattcct ccttattggc 3672601 atagtgatca taaaaggttg cacggcggat attgctttta cgcgtaatat ctgaaatcgt 3672661 gatgcccgcg tagtcttgtt tctccgccaa tacatccaga aatgccttct gcagcgcctc 3672721 tctcgttcga accacccgcc tgtcgatttg cttctccttc tctcgctctc ctggcacagc 3672781 ttttccaaac agccaataaa accgcttttg agaaacaagc tcccatacct tctggctgat 3672841 ggcttcagga gacgcggccg catcctcatt cagccaatac aggataatcg cgtacgtgta 3672901 caaggcccga taatgtccat aaatgtcccg ttcaatcggc gttaaattca catggatcgg 3672961 agccagcagc acatcctgct gaaacacatc cttaaaaaaa cgatgaaaat gtcctctgtt 3673021 catcatcaca gaaaaaaagg aacgatgctc atgaacaaag gacagcgtcg gatgcaccgt 3673081 ttgccgtttt ttgttcaaat gaagggtatc catatgactg aaggcgtcaa aaagcgcttt 3673141 gcccagtcct tccttcatgt cttcgatcac atcctcaatg attgaaaact tatcctcata 3673201 ataaaggtag agcgatccgc ggctcacttt ggccttctca gcgatttctt tcattgtgat 3673261 gtgttgaata tctctatctt tcaataaagc cagcagcgcc tctttcactt gagcttcggc 3673321 agattccggc acaaaagaca cctccaatca ttagacagat cttagatata tgtacggtaa 3673381 cgtatagatg gttcaccgtt gtctttctta cagaaaaggt accaccttat aataggtccg 3673441 agaaaagaag aaagcaaatg agggggattt tacaatggaa cagcaagtaa aggacgacat 3673501 ccagcgtgtc tttcagcttc agaaaaaaca gcaaaaagcc ttgcgcgctt caacagcgga 3673561 acagcggaga gaaaagcttc aacgcttttt agattccgtc atcgcccatg aagaagaaat 3673621 catcgaagcg atccgcaaag acgtccgcaa accatatcac gaagtcaaaa aagcggaaat 3673681 cgaaggaaca aaaaaagcga ttagagataa tatgaataac ctggaacaat ggatggcgcc 3673741 taaagaagtc ggttcatcgt taagccctga cgcaaacgga attcttatgt acgagcctaa 3673801 aggcgtcaca ctcatcctcg gcccgtggaa ctatccgttt atgctgacga tggcgccgct 3673861 tgccgcttct ctcgcagccg gaaacagcgc gattgtgaag ctgtccgatt tcacgatgaa 3673921 cacgagcaac attgctgcta aagtaataag agacgctttt gatgaaaaag aagtcgcgat 3673981 ttttgaagga gaggttgagg tggcaaccga actacttgat cagccgttcg accatatttt 3674041 cttcactgga agcacaaatg tcgggaaaat tgtcatgaca gcggctgcca aacacttggc 3674101 atctgtcaca cttgagcttg gcggcaagag cccgacgatc attgacagtg aatacgatct 3674161 gatggacgca gcgaaaaaga tcgccgtcgg gaaattcgta aacgccggcc aaacctgcat 3674221 cgcacctgat tacctgttca ttaaaaaaga cgttcaggac aggttcgcgg ggattttaca 3674281 aacagtcgtc aacgctggat ttatggagga tgatcatacc ccagaccgca gcaaatttac 3674341 gcagatcgtc aatgaccgca acttcaaccg cgtcaaagat ctgttcgacg atgccatcga 3674401 aagaggggcg gaagtggtgt tcggcggcgt attcgatgcc agcgaccgca cgatctcgcc 3674461 aaccgttttg aaaaacgtca cgcctgacat gaaaatcatg caggaggaaa tcttcgcatc 3674521 gatcctgcca atgatgaact atgaagacat cgacgaggtc atcgattacg taaatgaccg 3674581 cgataaaccg cttgcacttt atgtgttcag caaaaaccaa gatctgattg acaacgtcct 3674641 tcagcacacg acatcaggaa atgccgccat caatgatgtc gtcgtccatt tcagtgacgt 3674701 caacctgcca ttcggcggcg tcaacacaag cggaatcggc tcctatcatg gggtatacgg 3674761 attcaaagag ttttctcatg agaagggtgt atttattcag gccgctgaat aatcgcatga 3674821 tcaaaaggcg cttccttaga ggagcgcctt ttattgtaac tccttgacca aaagcaattc 3674881 atcacggata ggtattttat tatctgccag taaaggaatt tcgggcttca tctttctggc 3674941 cgtctcgact gcattcacaa atagtcgatc caaccggtac cctctcttct gataaaacgc 3675001 taatgcatga atattatcat tggttgtgat cagttttatt tgtttgatat ttctctctct 3675061 gcatgcttcc tcggctttct ctagcagagc tgttccgatc cctttattct caatgacact 3675121 atccagcgaa atgatttcac aggcatcttc ttcaaatatg tatgtaataa ggccaacaat 3675181 ctggttatca tcgttgagca ttccataacc atctaattca tcgcagttat aaataccgct 3675241 agaaataacc atttgcggac tgccccagtg tttttgaaaa aacgcggaaa caagatcttt 3675301 aggtacctgg catgtcggaa taatattcat attttcctcc ttttagctga acaaaaataa 3675361 gagaattaac aacctatttt atgtcattaa tccccttatc tagtatttac tagaacttat 3675421 aacttgtcaa aagctgtctg aataccaatt gcgtggattg ataaggatca aaatctgaat 3675481 cctgagattg gaagatttgc tctggggtca atgtctctgc gttctctgat aacgtttgaa 3675541 tcagactttc caaatatcca tttaactctg atttggacga ttcatgtagg gattgatgat 3675601 ttacagcgag ttctctaaat ctgttatcac tgattaattt ttttcgaaga gctgctagca 3675661 tcaagtcaag ccatgcaggc tggccaaatg taatatttaa agctaacgtt gcttgatcag 3675721 atttggtgga gtgccataaa cctcttggca aatacagcat ggttcccggt gttaaattaa 3675781 cgatttctgc atctggcaga tcctcttttg gcggatctcc tttccaatat gactgtaaat 3675841 catcaggata gtaaggagcc tctgataaat catagtgctg cattggattg ctcacatttt 3675901 cattcttggc aagcttccat gttttctcac cttgaatttg aaaaatcaag ttggtgtagg 3675961 cgtcaaaatg ggctttgaat cccccgccat ttttcgccgc gtaaacaatg gctttggaag 3676021 aagtacccgc aggcagtctt aattccgctt tgagtttttc tatccacctt ctgacttggg 3676081 gaataaatag gtcggtgaaa tcaaactcta atgcagcccc tttttcatac cactctaaag 3676141 cctctgcagg tgacacaaga aatctgtctg tgatcccttc agattcttca atcacagcat 3676201 caccaacgac catgactgga ttattgtaga tagccaatac gttttctagc gttctaacct 3676261 tttcaaaccc cggtatgctt gtaaatctct ccacttctcc tctggctacc aaaggtttta 3676321 caggccaata ttcttctaaa aactcactca tcgttacagg actgatgata gactccaaaa 3676381 ccgattcggt tacagcactc atattatccc tcccaaaaaa agtaacttca ccacaaagat 3676441 ataacatttt tttctaaaag taaatattga cagaattatc agaggattat aatatttagt 3676501 tgtgcgtgat agcctatttt tttacaagga aggagggaaa aggatgaaaa aggcttataa 3676561 gaaacctcgt ctttttgaac tgcgccgtgc tgtagcagct ggcggccatt aatctcatat 3676621 agcatttgac atctagtact ctattttagg agggatgctc aatgaaaaaa gcttataaga 3676681 aacctcgcct ttttgaactg cgccgtgctg tagcagctgg cggccattaa tctcatatag 3676741 catttgacat ctagtactct attttaggag ggatgctcaa tgaaaaaagc ttataagaaa 3676801 cctcgccttt ttgaattgcg ccgcgctgta gcagctggcg gtcattaatc ttatccaaaa 3676861 cgattaacgt ttgaggctat cacgccaact tgataaggag gatgctgaag atgattacgg 3676921 ctgaagaatg cagaacgtac aaagaatttg ttgatcttta ccaatcctat ctttacccct 3676981 tgcttggcgc cagactgtcc cggatgtatt cccccaaaaa caaagtcatt atcgatatgg 3677041 gcacaggtcc aggttattta agcattcagt tggctaaaag aacaaatgcg cacgtgcatg 3677101 ctgtcgatat taacccggcc atgcatgaaa tcgctcaaga agaagctaaa aaaagcggag 3677161 taagcagcct gatttcattt gatttggaag atgtccacca tttatcttac gctgaccaat 3677221 atgctgactt catcgtctcc tactcttgcc tgcatcattg ggaagacgtt gttaaaggac 3677281 ttaaagagtg ctatagagtt ctggctccgg gcggaaaaat tgtcattttg gatacattta 3677341 atccccaagg aagccattta gagattatgc gaaaacaaat caaagaaccg gaatacttca 3677401 ggtttgtaag agaggcattt gaagaaagtt attcctttga agacattcac cagtttgttc 3677461 aggatgccgg cattcccaat tattcattag aaacctttca ctttttaccg gaggatttta 3677521 tagaaagctt agatgagctg gaggatgctc ccctgtggga acaaaatgat caaagtactg 3677581 atcatgaaat tgagtctgtc acatggatgt taacgataga aaaagaaaag gaaggtgcat 3677641 tgtaatgatc aatgaatcaa ctgttttatc caaaaatcca gaaatgccat caagaaaata 3677701 tttgaaaagc attattatag agccgggcat cactttaaat gaaatggcat cagatattta 3677761 taaccatatc gacggcaagg tcagcataca tgatatttgc tcaaaaatcg tcaatgaata 3677821 tgatgttgat tatcaaacct gcttagaaga ttgtatggag ctgtttgagt tgcttattga 3677881 tcatgaagca atcaaagtta agcagggggc atgagaattg gaaaaacaaa aagtgcttgc 3677941 tttaccagac gatgtacatg agctgagtac acaccgttct aaatcaatcg taaattacat 3678001 catcactctg cttgcctttg ccaaaaaaca aggattgact catcaagata ttgtaagctg 3678061 gattcacgag caatatgagg aaagaggata ttatgatgag tggagacaca ttaacagcca 3678121 acaaccagtt ggatcatttg tggaactctt tataaaagga agacgtttac tttatgacaa 3678181 aattgaattg tttgaaacag aagataaata tgtcgtaaat acccacactt ggtatgaaaa 3678241 agaacctagt gaggcctttt tttattttga aattgatccc gaagaatttt ctgcgtacgc 3678301 ttccattctc gcaatcgaaa acgcaaaacg tctcggaatt aaaatcgata ttgtaaaaga 3678361 aacagatgta gagacagctt atatctataa acatcaataa cgctattggg agggagacat 3678421 atgtgcgggc tcgcgggtat tataaatctg gctgctcccc gttctcagga atgtaccttt 3678481 catatattga aaggcatggc agatgccatc agctataggg gaccggatga tgaacaatat 3678541 catattgatt ccaaagtcgg ctttgcattt cggcgattgt ccattcttga ccttgtaaat 3678601 ggacagcagc cctttttaaa tgaggatgga tcaatcgtcg ttatggtaaa tggagaaatt 3678661 tataactata aagaactgaa ggcttcttta cacaatcata tgtttaaaac gacatctgat 3678721 tgtgaagtaa ttgttcattt atatgaagaa aaagggattg gatttgtaga cgacatcatc 3678781 ggaatgtttt caatagccat ttgggacaaa aataaaaaca aagtattttt agttcgtgac 3678841 cgctttggga ttaaaccgct tttttacaca gagctaaaac acgagcttat atttgcctct 3678901 gaaataaaat ccctattttc tcatcctcac tgtccccgcc aatttaattg gaaagaagca 3678961 ctctcagaca tttggctaag cggggaagca gccagtaatc ataaagaaac cacttccttt 3679021 tttgtaaaca tccaaaatct cgatgctggc cattatctcg aaattaattt gacaacaaat 3679081 gaacgaaaaa cagcaagcta ttggtcttta caggatattt tgctcaggca aggctatcgt 3679141 gagaatctcc atcccgatga cctgattgaa ggatatagag aactgctggc agattcagtc 3679201 catagatgtt tacaaagcga cgttgaagtc gggttgtttc ttagcggtgg cattgattca 3679261 gctgcagtcg cacattttgc tgcagaaaaa caggatctcc atacgtttac agtattaagc 3679321 caaagtacat ttacaaatga agatgcaaaa tatgcccatt ggctggctaa agatttacac 3679381 cttccaaatc atcaggttct ctatcaatta gggaacgatg agttattaca accagagtca 3679441 tataaacatt tgttatggat ctgtgaaaca ccgttttgcg gaccggaaca attatataag 3679501 tttcatttac ataagtatgc caaagcgata aggccaaacc tgaaagtcat gctgaccggc 3679561 cagggcagcg acgaatttaa cggcggttac agcacgacac tttcaccagc cgagaaccca 3679621 agttgggaag gatttattga atcggtcaat acgatggaga tgaaccggct gcatcggctg 3679681 cagggaaata tctttagagt gtgggaggag cattttggac tttctcctat aaacctttct 3679741 tatttaaaga gcaatgattc cagccaagca gatccttggc aatcgtatgt cctgacaaaa 3679801 taccgtgatc tgcaaatgta taattgctgg catgaagatc ggatcgccgc ggctaatcat 3679861 atcgaaaacc gtgtaccgtt cttggaccat cggcttgttg aatgggtttg cggaatacct 3679921 gatggactcc gtaaagactt gttatgggat aagtcggtat tgcgaaaatc attaacaaat 3679981 gagctgcata caagctatac ccaccggcca aaggttcctt ttttctatgg taaggacgtg 3680041 agatatacac ataaaatgat gtttcatctt ctgaagaaaa acaattatca gcttatagag 3680101 gaggccttct ctcacagcga tgcctccagc ataatacagg ttgaacacat tcatgccatc 3680161 atgacatatt tggaggatga tcctgagttt acaaattttg aatttttatt aagactggtg 3680221 aacatgggac ttttatcaaa aatgactaaa gaaacccctt ctgttcaatt agacataacc 3680281 agccatttag aatcgataac aataaaagac tggcactcac aggaaggtga tattgccagt 3680341 cgtttaaata tctcagccaa taagtgtgaa ggacaagata ttttggcgct aaaccctggc 3680401 gtcactctgt taaggccgga aagcgatagt gagcattgca tctacattgc ggaagaagga 3680461 tttattcagt ttattgtttc ggaggaagac gtcggagctt ggctgcatat tctctgcgat 3680521 attaatggaa aagacacact tcatacgatt ttagacagac atggtgtcag ccttgaagaa 3680581 gtggccaaat atattcaaga agccatcgaa cacaatatca ttttgatcaa acaaaaaaat 3680641 ctgccagaag gagcatatag atgagcatct tttattcgtt ttccgcactt aggggattag 3680701 caatggggat tttttcgcct atttggattc tttatctgat atctaaagat tatgatttcc 3680761 ttcagattgg attaatggga gcggtacttg aaattgctaa gcttatattt gaagttcctt 3680821 ccggcgtttt tgctgatcgt tatggaatta aaatttcaat tgccagttca ttctttttct 3680881 ccatccttac atgggccttc ttccctttta tcgattcagc tgctatttgc atactggcta 3680941 tgatcatatg ggctttatca gattccttaa tttccggttc ttttgaaact tggatgagcc 3681001 gtgtcgcagg ggaagatcga ttcggcaaag aaatgatgaa aaacacacaa ttgctaatca 3681061 cttttttaat tattggaagt attgccagcg ggtatttgta ttcattaaat atctattttc 3681121 ctttcctgct cgttatggtg atctacttat tactatttat ttggatgtct gtatttatta 3681181 aagtcccttc tgtttccgaa acaaatcatg gggatcagaa ccaacatgat tcgataaaga 3681241 ttatcaaaga aagtttaaaa attatcttta acaaaaaaag ggttctttta atcgtcatag 3681301 ccggtttctt tacagccaca gcctatgaca caatttcccg ttactggcag ccttttttga 3681361 gtgatttagg cttttcagaa aagtcactgg gatatatttt tgccctagga gggtttaccg 3681421 ctctcgttct tttgacatta accatcaggt tcgaaaagaa gatcgaaaaa aatccatatc 3681481 tcgctttaac ctcattggat tccatgggca tggtcatgac ttttctattg tctagagcat 3681541 tcaggccgct gggcattcca tgtacagcgt ttttgcttgc aattgaagat attcatcatc 3681601 cgatcgtaac aagttactta aataagtttt tccccgattc atacaagaac acacttttct 3681661 cgttaaactc aggggtagga gcaattggag aaattctttc cggtgtcatt ttcggcatca 3681721 tttccgcagc ctttgggctc tctgccatgt ttgttgttgt agctgtattt ctattaatcc 3681781 ctattatcct ttatacgata gtgcctaaga ttaaagacaa tgatatgaaa gttcagattg 3681841 aaaaatccca gcaagtgtaa atgttttgta tcacagtaag aagaccttct tattaaaaga 3681901 aggtcttctg ctattctatt cagttatttc ccaaaagcca tcagcttcgt ataacttcca 3681961 atataaagtg ttccgtcctc agcgagctga ggagaagaca cgacgttgct gtcggtttga 3682021 tagctccata attcattgcc gtttgcgtct gccgcataaa ccttcatatc atctgacccg 3682081 aaataaaccg ttcccttcgc gtcaatcagc ggcgccgttc tgacagggcc gtctgtgtag 3682141 aatgaccagt tcatatcccc gtttttgctg atggaaaaca gctcgccgct tcctgagccg 3682201 atgtagatat tgccattatg atcaatcgca ggagatgagc tggagaaccc gtttagcggg 3682261 aatgtccatt tcaaactgcc tgttgatgta taagcataca gctgtccatc ttggttgccg 3682321 gcataaatgt ttccgtcctt atcaatcacc ggatatcctt taaacgcatt tgacgtcgtt 3682381 ctggaccatt tcacctgtcc ggttccggag ttgatcgcat aaaacacgta attatatgtg 3682441 ccgacataca cggtgccgtt tttggcaagc accggcacag agctgacgac cccatttgtt 3682501 ttcaacttcc agcgctctgt ccaggttgat tttgacgtcg gtttgatcgc gtgaacataa 3682561 ttatcaagtg ttgagaaata caacgtcccg tctgaaccga tcaccgtttc agagcttggc 3682621 ccgccgctta acggaaccgt tgttaaaatt tctcccgttt ctttgtcaat aaaataaatc 3682681 tttttgtcat aggatgccaa atagataacg ccgttggtcc caagtacagg agattgcgta 3682741 tatgtttttc caagattgcc cgtcacccat ttgactgagc cgtctggatt aaaggctttc 3682801 atttccccgt ctctggaatg aagatatact gtgccgtctc cgtcaatcac agcccccgct 3682861 ccattttgcg gagtcgttct gatgtcgttt tgccatttca gcgtcccgtc tgtatttccg 3682921 gcgaaccggc tttcgcgtga ccagttaaac atggcaggcg ccatcgcttg tacatcatat 3682981 cttcctggca aaaagccaga tgctccatta ttttgagaaa acaccgtttc cgccgcataa 3683041 gcagctgtcg gctgaagcac tttggcagcg ggcacatcag aaacagcgcc ggccgaaaca 3683101 gccgccgcca ccgcagctcc cgcaatcaaa gctttcatac gaaatgactt gaccatcatt 3683161 gagaccccca ttatatgtaa cttctaattt gtgaccatca taacatattc atccatttta 3683221 taaatctatt tcacaaaaac atcacaaact agaaaactat gtaagagtat tcacggacgt 3683281 tttttcagca cccgatcgaa atgcagccac aaaccaaatg acgttgacag cagccgcagc 3683341 gagactaact cccaaaacaa agatcacctc agaaagcaga tggtcactaa agaaactaaa 3683401 catcaagata aaaccggccg aagacaaatg aatcaaaagc ccgaagccgc aaagcaccgc 3683461 catgacatac ctcattgcat cgactccgag catataaacg agaaatggaa tgaaatacaa 3683521 gacaaggatc ataccgacag ctgaccacat gccagctgaa ttaaactgat tggccgccgc 3683581 tcccgttccg gccagcggcg aaagtgaagc cgccacaatc acggcgcaaa aaagaaacgc 3683641 agaaatggtt gtcatgatcg ccacgctatt tttttttgac atcaaactcc tcctttaata 3683701 gaaatattaa ccttttttat tataagtaag ttgaatgtta tattcattat atttttaaaa 3683761 aattccagaa tacatacaca aatgctatgc ttctttctag tatatttata tagtaaaaaa 3683821 caaaggataa aagactcatt tttctgtaat atcaggattt tatcaccata ccatattgca 3683881 tgtacatgtt tttcaaagta tactattcca gattaattca gaggagagag aaaaatacat 3683941 ggaaaaacca gcaggatttt ggattcgttt tttagcttat tttattgacg gcattattgt 3684001 atctgttcct agttatatta ttctatttat tatcaattct gtgtttgtag ctggggctgt 3684061 ggcaacaaac ccttacatga cggaagaaga gtatttagtg aaatacatga cgcttgcatt 3684121 tttgcctact atgctgatca tgatcgtcat cagcgtgtta tattacgggc tgctcacagc 3684181 ttctaaaatg caaggcacac ttggcaaaaa aattcttggc ctgaaagtgg tcaatgaaca 3684241 aggtgaacgg gtttctgtcg gacagggaat tggccgttac tttgcctata tcttatctgg 3684301 aatcatcttt tatatcgggt ttatcatgat cgcctttgga gagaaaaaag gcctgcatga 3684361 catcatttgc aaaacacgtg tcgtgtataa ataatagaaa aaagtctaga cgccaatagg 3684421 catctagact tttgttttct ttgcaatagg ctgccacgac agatacgtag cgcttctcca 3684481 caaccactca aacggcccca tccgaaagac acgaagccaa aggtggctga agaccatttg 3684541 aacggcacaa acagcaattg taatgagcac accggcagca gggtacactt ttccatacag 3684601 gcccaagccg taatgataaa aaatccaagt acacacaata gactgcatca aataattggt 3684661 aaatgccatc ctcccaacag cggagaatga ttgcagcact gttctcactc ttgttttatg 3684721 ataaagatag acaaccgttg taacatagaa aaacatgagg aaaggcgcgc caatcagcaa 3684781 acatatttct ttatccgtta cactgtacag cacctgggcg ccgatgccga tgacaagccc 3684841 agccatccat aatcgtttta atcctttgcg atgcttttcc ggttcatgca aataccgtga 3684901 ttttgctgcc gcagctccca gcaaaaacat gctgaaatat ggaatggatg caaagaagta 3684961 gttgagcgga ttatacgtaa gcatgccatt cgaagacatg taaacaagac ggtcgtggat 3685021 ccgctgttct gcaatatcct tcaggctgcc gcttccataa acatgaatcg cttgttttgc 3685081 ctgctgtgtt accgcttgta cccattcctg tccgtttgat tgatcaaaac ttgtcaacat 3685141 gaacggaatg gaaaacagaa gatacaaaga gaccgcccat atcagcagtg ttttcggctt 3685201 tgcttttcga aacaagagca ggacaaatcc gagcagggca tattctgtta aaatatcccc 3685261 gtcccatatc aaaaaggcat gaatcgttcc aaacaagaga agcgccatta accttctcac 3685321 atataacgga acaaaccgtt tccctttgtt ttctgctctc tccatcatga caaccatgcc 3685381 aaatccaaat aaaaaggaaa acaataaaat acattttgtt tgaatgaaga atttcagtat 3685441 gtctgcggcg gcaaaatcag cttcagacca cttatccatg aaaaaattct cttttccaag 3685501 catagacaaa tacatatccg gataactgaa atgtgccaga ttgacaaata agatgccgaa 3685561 aatcgccatt cctctcagca catcaagcac accgatccgc tcatttgtta aagtcggctg 3685621 taatgaagac atagccatca cgctcctttt ttctgtacct taagggtagg aaaaaatgaa 3685681 gcgcggtaac atcgatttag gtgtcaggcc ggcatgaaaa ccttacaatc ttgtcatctt 3685741 tatggtttca tcacctttaa atctaatgct tcgatattct gcaaaatgcg atcaaagcgc 3685801 aaagcctgag gctcacatgg gaagatgtgg ccttcatacg ggtcgcctaa cgtccggaaa 3685861 aacggttcaa ataaaccagg aaccaatacg cccaccatct ttgtatagtg agaatcaagg 3685921 cgataggagt gaacggtatt tgcagggaca tgcaggaaat ctcccggatt cagctgaatt 3685981 tcctggccat ctgtccacat cgtcatctgg ccttcaaggc aataaaatgt ttctgtatga 3686041 tattcatggt agtgatcaac gattcggtca cctttagggc cttcagatga tacgacgata 3686101 aactggccat ctgtattttt ttgtgcagcc acaatgcggt gaagctgatc tccagtcaac 3686161 agacgatctc cttctccaga ttcaagaacg tatggaaccg ctccatctgg cagctctgta 3686221 agttccgcta atttggccga acatgcaggc tttgcttcat ctagaaatac aatgtccgct 3686281 acagcggctg cttctgcaaa tcgctcgttt gagacttctt cgcttgcgta cggcggatgt 3686341 tcagcgtgat catacggatt cccaataacg gaatacaagt gcgctacgtt tcctttcatc 3686401 gtgtaagaca ccagtcttgt tctgtggctc tgcatccggt agctgtgcgg tgttcccgcc 3686461 ggaatgttgg cataatcacc tgatattaat aaatagcgtt caccatcaag tgtcagttcc 3686521 agtttcccgt ccaaaacgag aattccttca tgtgtgtcct tgtggacgtg aagcggaaag 3686581 gcatctcctt ttcccccgga aagaagcacg atctcaaaca aatcacctgt gctcctccca 3686641 ttcgccatca ccgtggcaac ctgtctgccg aacagatagc gctcgccttc tccgctccgg 3686701 agcaaataag gcattttttc tttaggcaat gaatgtgtac ataatgtttt catattatcg 3686761 cttcctccaa tttagaccag tctatatatt atcattcatt tgtctagacc gttctatata 3686821 attgtaggag aaaggataac aaaatgctac cctttttttc tcaccagcac tggtatttgt 3686881 tcggcaatga gaagaagagg cgttttgtct ttattcgtta acgaaagcat gatgccgccc 3686941 tcaatcatcg aattaatcag cgttccaagc tgatttgctt cttcttctgc aaatccgttt 3687001 tccattaatt ttctggcaaa aaccgcttcc cagcttttaa acaccttcat gcaaaccgtc 3687061 cgcagcggtt cactgattaa cgctgtctca ctcgccagca aaccgactgg aataccttta 3687121 atgctttctg tgttgtcaaa ttggctggct gtttttttga taaaaagctg aatcgcttca 3687181 acaggatcag aggattcatc catgctttgc tgtatcagat gttcaacgat cttacctgta 3687241 tatgtaaccg cttcaattgc tagttcttct ttgccattcg gaaaaaagtg ataaagcgat 3687301 ccttttggag caccgctttc ttttacaatc tggttcaaac ctgtcgcgtg atatccttgc 3687361 agctggaaca gacgtgacgc cgtgtgaagg attttttcac gtgaatctcc tctgctagtc 3687421 attaaaacat tccctcctag gtatggtaga gcgacttata taatataaaa aagaaccctg 3687481 tgattgtcaa aaggggtaag acccttccgg atggggtaat gtacaaaaac agcgtctagg 3687541 agggatctct caatgacaat cgatcattca gtcacaaata cagagcagct tgaacaacag 3687601 aaccccgcca taaaaacaaa gctcaaactg aaaaagctta aggatcaggt gatcgtcatt 3687661 accggcgctt caagcggtat cggacttgtc acggcgagaa tggcagctga aaaaggcgca 3687721 aaggtcgtgg cagcagcgcg aaatgaagag gcgctgaagg agctcactga tgaacttaag 3687781 gaaaaagggc acgacgccat atgggtaaag gcggatgtcg gaaaagaaga ggacgtcaac 3687841 cgcatcgcag aaaccgcgat cagcacattc ggccgctttg atacatgggt caacaatgcg 3687901 gccgtctcga ctttcggaca cgccatggac gtcaccgtcg aagacatgaa gcgcatgttc 3687961 gacacaaatt tctggggacc tgtttacgga acaagagcgg ctgtcaaaca ctacaccggc 3688021 agaggtgtgc cgggcgcact cattaatgta ggaagcctgt tcggagacag gggaacggtc 3688081 attcaatcca catatgcatc tgccaaattt gcgcttcacg gctggacgga aagcatccga 3688141 atggagcttg aaaaggaaca ggcgcccgtc tcggtaacgc tcatccaccc gggcagaatt 3688201 gacacaccat ataacgagca tgcgcacagc tacctcgaca aacagccggc tcattaccgc 3688261 tccatgatct atccgccgga agcggtcgcc gaagcgatcc tgtttgccgc cgaacaccct 3688321 aagcgcgaca tgtacatcgg ctcacaggcc aaagccatcg ccatgctggg cgcgcttttt 3688381 cctcgtctga ccgacagact gatggaaaaa atcatgtatc acagccagca tgccgaaaga 3688441 ccgtccaatc cgagagaaga aagcgctctt tatgatgctg gctgcggtat gcatgacaga 3688501 ggcacaaata aaggatggat gaggtcaaga agctactaca caaaagcgac gaagcgccca 3688561 attgtatcgg cggctgttgt tgccggacta gtggcttggg ctgccgccaa acgatgcaga 3688621 taatctctga ccataagaaa aacccatgct gttccagcga accatgggtt tttcagctgt 3688681 taatcgataa aagccttgtt catacgctgc agcagctcgc cgaacatctc tttttcctgt 3688741 gttgaccatt ctttcagcat ctgttcataa cgttcaaggc gcttttgctg atcggctttt 3688801 aatagttgtt tgccgagttt tgtaatggta aacaggctga ctctcccatc agacgggtct 3688861 gagaaacgat agatgagctc ctttgcctct aatgcagctg cttgtcttga aagagtagaa 3688921 atatcaagct taaacgattc agccaattcc ttaacacgag caggcccaaa ctcatccaat 3688981 tgtctcagta ataagtacga agatctctcc aaattccctg ttcttttctc cgattgatcc 3689041 agataaacag ctctcctgat aaaagtcgtc agctcatatt caattaattc aactggattt 3689101 tgattttgca atcgctctcg ctccctattc caatctccgg cattgacaac atcatatata 3689161 cttgtataat acaaatgtac attaactgaa taaatacaag tcgttatatg actaaatcaa 3689221 ttattatact tgtatagtac aatcatataa aaagaaagta aagcgattcc tcagaaccat 3689281 cctagaagca agcaccagaa aggaggaagc tgttctgatt ggagagcagc acttgatgtg 3689341 aaagtcatac gaattatttt gcaagtgttg atattatatg tattttttat gatcggggaa 3689401 gccattcagc atctgtttca tttacccgtg tcaggaagca tcgttggatt ggtattgctt 3689461 ctgatctgct tgggcctccg tattgttccc gtctccatca ttgaagacgg agcagggttt 3689521 ttattatcct tccttccatt gttgttcatc ccggcaatga caggagtgat aaactatccg 3689581 tctctcattt cattcaatgg cctgatgctg ctgattacag tcgttctcag caccatcgtc 3689641 acgatcattg cggctggatt cgccagccag ctattagaga aaaaagcaaa aaaacgggag 3689701 gagaaagaga aatgcagcaa gcatgtatcg cgatcattat aattctttta acagttgccg 3689761 cttatttagc gatggtcaaa ctctataagc gattcccgct tccatttctg atccctgttc 3689821 tgacaacgac aattttgatt gtagcggctt tgatgatgtt tcatgtttcc tatgaaggct 3689881 atatgatcgg ggggaaatgg atcaattctt tgcttgggcc ggctgttgtg gcgctggcct 3689941 atccgcttta taagcaatgg catatcattg tcaaacattg tgttcccatt ttaggcggcg 3690001 tcctggtcgg cttatgcatg ggaatgatca gcgggctgat cttcgcagaa gcattcggga 3690061 ttgatcatga tctcttatta tccattctgc caaaatcgat cacaacccct gtcgctattc 3690121 agatcgccgc cggtcttggc ggcgtccctt ccatgacagt cgtatttgtc atgattgcgg 3690181 gcttttcagg cgtcatcctc gggccgcttt tcctaaaatg gcttcgcata cgcagctccc 3690241 taggacaagg cattgcatta ggcagcgcct cccatgcact gggtacctcc aaagcgttgg 3690301 aatatgggga attggccgta tccatgagtt ccgtctccat gacgctttgt gcggtgctcg 3690361 gctcattctt cggcccgctc gtcgtctggc tgtttcatat ttaacaaaga aagactgccc 3690421 cgggggaggg cagtcttttt cgtttaagaa gcaaaaaaat caatcaacgg ctgaaagtcc 3690481 ttagataaat caacgtcatt cggttctgct tgaagcaggc ggtcaatcat acgctccagc 3690541 tcctcaacat cattcttatc cgtatattca atgaagttta agctttcaag ccaatcccga 3690601 tatgaatgtt tggctttgcc atagctgttt ccaaagacaa ggcaaggtgt tttggtgata 3690661 atcgagaaaa tcatcgcgtg aaggcggtcg gtaatcacca atttactgga gccgatgcgg 3690721 tccagcatct ccataaaatg cttttcacga tcagcgtaat cgatggtgtc taccgtatcc 3690781 agcaccgtat cggtacgctc tgtgtaagtt gttttttctg cccattgctt catctgtgaa 3690841 ataaaatctt cgtcagtcac tttctcctta tccgctctta aaataaagag aacgccgtcc 3690901 cgctcgagct ctcgcggcac aatatccaag gaaagcacca tgtccggtgt aaagatcaca 3690961 ttggagttga aggtctcttt cacaacatcc agtgtttgcg tctcacgcgc agcaatcgtt 3691021 aagtttgtat tttgatggta cgcatcctgt gtttttttct tttccttctg tccttcctct 3691081 gtatcctcaa aataaacgga ttgtggcaga gaaattgatt tgtagtcttt aaacgccgaa 3691141 aagacctttc ttctgtcttc ctcaatatcg agataaaggt ttcctaaatt ccctccgcct 3691201 gtaaagcaga caatatcgtc ttcacgaatg atctccttca ccagttcaat gccctcatcc 3691261 gtcgcataat ccataatctc aatgtattca taatacggaa aatgattttt gataaatttc 3691321 tcttccgcat acgcaatcgc ttggtcgcca atgtttgtgt agctagggga accaaacaaa 3691381 aatacttttc gtttatcatt taacagagct tccggctcca catttggcgc aatgcctttt 3691441 actagttttt tgcctttgat ttcttgtaca gtcatatctg cgtcctcctt ctgggatgaa 3691501 ttcctcattg tgtgttaact gtctctaccc aaaaagaagg atggctatgc attggcatgt 3691561 gcatcggcta tatcagaaac atcgttttcg ccaatttgat agacgctgca atgtcccgcg 3691621 ccgttctttc catatattcc gcggcatgtt caaacgcgtc ttctagtggc acggctccgg 3691681 ggacgatgct gaaaagcgca tcgattccgt gttgatagac ggcattactg tctcgggaaa 3691741 ttgatcccgc aatgccgata acgggcacat cgtatgattt agcggccttg gccaccccga 3691801 tcggtgtttt tccatgaacc gtttggctgt cgattcgtcc ctcgccggta atcacaaggt 3691861 ctgcatcctg aacgatactt tcaaaatcaa ccgcttcaag gacaatatca atgcctcttt 3691921 tcaggtcagc ctgaagataa gttagcaggc tccatccaag accgcccgct gcaccggcgc 3691981 cctctgtatc tcggaaggtt gatccgagcg ctttttctgc catatcagcg aaatggctta 3692041 cgttctggtc tagtacatcc aacatgtcgg ccgtcgcgcc tttttgcggc ccgaaaacag 3692101 ccgtagcacc ctttggtcct gttaacggat tgtccacgtc acaggcaact tccagtttga 3692161 cattccgcaa tctggaatca agcccgctca catctattga tgcaagctga gataacgcgc 3692221 cgccccctgg gccaatctcg ctgcctgagt tatcaagaag ccttccgccc aatgcctgaa 3692281 tcatcccggc tcccccgtcg ttcgtggcgc ttccgccgat tccgatgatc aatcgctccg 3692341 ctcccgcatc aagagctgct ccgattaatt ctcccgttcc ccttgttgta gtgatgagcg 3692401 gatttcgctt atctacaggc accagatgca gccctgaagc agcagccatt tcaatcacag 3692461 ctgttctccc atctcccatc atgccaaaga aagctctcac cggttccccc agcggccctg 3692521 tgacaacttg ctctatgatc cttccattgg tcgcatcgac cagagattga acggttccct 3692581 cgccgccatc cgccaccggc aattttctgt aatcagcacc cggaaagacc gatttgaaac 3692641 ctctttctat cgcttcggct gcctccagag ctgataagct ttccttaaaa gaatcaggtg 3692701 caatgatgat tttcatccaa atcgcctctt tcaaaacatg attcacttaa cctattgatc 3692761 tccaatgtac cataattgat ctggaaatac ataccatgca atatggtaaa aatttaaata 3692821 aaaattagaa atgaaagtgt ttgcataaaa gaaatattca cgttatcata cttgtataca 3692881 agtatactcc ttgagtgagg aaggtgagtg tatgctagac tccaaagacc tgttgtatcc 3692941 cgcaaaatgg ctctcaaaag cgtcaaccgg agttcgtgtc gcatacgagc tgagaatgcg 3693001 gatcgtttca ggtctgattg aaagcggtac cattttatca gaaaatacaa tcgccgccga 3693061 gttttcagta agccgttcgc cggttcgcga agcgctaaaa atactcgcat ccgaaaaaat 3693121 catccgctta gaacgaatgg gagcggtcgt aattggttta actgagaaga aaatcgcgga 3693181 aatttatgat gtgcggttac tattagaaac atttgtcttt gaacggcttg tcaaaataga 3693241 cattgagcct ttagttaagg atctcagcaa aattcttgaa atgatgaaag tctcaatcaa 3693301 atatgaggat gctgacgaat tttcatttca agatgtgctg ttccatgaaa cgattatccg 3693361 agcgattgat cattcataca ttcagatgat ctggaacaat ctaaaacccg tcatggaaag 3693421 ctttattctt ttatcgatgc gggtacggtt aaaggaaaag tatgaagact tcacaaggat 3693481 tttagataac cacgagcttt atattcaagc catcaaaaca aaggataggg cgctgatgat 3693541 tcagtctctt caccaaaact ttgatgatgt gcaggataag gtagaagacc tatggctctc 3693601 acaacaaatg ctggcaaaag gagctgaata caacaatgac tagttatatg ttaggaatcg 3693661 atatcggcac gacaagcaca aaagctgtgc tgttcagtga aaacggagat gtggtacaga 3693721 aagaaagcat cggctacccg ctctatacac cggacatctc aacagctgaa caaaatccgg 3693781 aagagatttt tcaggcagtc atccatacaa cagcgagaat tacaaaacag catcccgaaa 3693841 aacggatctc tttcatttcg ttcagcagcg ccatgcacag cgtcattgca atcgacgaaa 3693901 atgacaagcc gctgacgcca tgcattacat gggccgacaa cagaagtgaa ggctgggcgc 3693961 ataagatcaa agaggaattg aacggacatg aggtgtacaa acggacggga acaccgattc 3694021 atccgatggc accgttaagt aaaattgcct ggatcacgaa tgaaagaaaa gaaatcgctt 3694081 ccaaggcaaa aaaatatatc ggcatcaaag aatacatttt taaacagctg ttcaatgagt 3694141 atgtcatcga ttactcattg gcatcagcga caggcatgat gaacctgaag ggcttggatt 3694201 gggacgaaga ggcactgcgc atcgcaggca tcacgccgga tcacttatcc aaactcgtgc 3694261 cgacaaccga gatctttcag cactgcagcc cggaaatagc gatccaaatg ggaatcgatc 3694321 cggaaacgcc ttttgtcatc ggcgccagcg acggcgtgct gtccaacctc ggcgtcaacg 3694381 ccattaaaaa gggtgaaatc gccgtcacca tcggtacaag cggtgccatt cggacgatta 3694441 ttgacaagcc gcaaaccgat gaaaaaggga gaattttttg ctatgccttg acggacaagc 3694501 attgggttat tgggggacct gtgaacaatg ggggcatcgt ccttcgctgg atcagagacg 3694561 agtttgcctc ctccgaaatc gaaacagcga cacggctggg cattgatcca tatgacgtgc 3694621 tgacgaaaat tgcccaacgc gtcagacccg gttctgacgg tctgctgttc cacccatatc 3694681 tcgccggaga acgcgctccg ttgtggaatc cggatgtacg cggctcattt ttcggcttga 3694741 ccatgtcgca taagaaagag catatgatac gcgcggcatt ggaaggcgtc atttacaacc 3694801 tgtacacggt gttcttggcg ttaactgaat gcatggatgg cccggtaacc cgcatccaag 3694861 cgacaggggg ttttgcaagg tcggaggttt ggcgccaaat gatgtcggat atcttcgaat 3694921 cagaggttgt cgttccggaa agctacgaaa gctcatgtct cggcgcctgc attttaggcc 3694981 tgtatgcaac aggaaaaatc gattctttcg acgccgtgtc cgatatgatc ggcagcacat 3695041 acagacatac gccgatcgaa gactcagcca aggaatacag aacattaatg ccgattttca 3695101 tcaatctatc aagattatta gaaaatcaat atacacaaat tgcagattat cagaggggct 3695161 taatcacaca caaatagtac atgacatgaa ggggagggca ttaccatgcc gttaatcatc 3695221 gttgcacttg ggatcttagc attactattt ctgattatgg gcttaaaatt aaacacattt 3695281 atttccctgc tggtcgtatc gttcggcgtg gcactggcac tcgggatgcc gttcgataaa 3695341 gttgtcagct ccatcgaagc aggaataggg gggactcttg gccacatcgc gctcatcttc 3695401 ggactcggtg cgatgctggg caaactgatc gcggattcag gaggcgcaca gcgcattgcg 3695461 atgacgctcg tcaacaaatt cggtgagaaa aatattcaat gggccgttgt cattgcctca 3695521 ttcattattg ggattgcgtt attttttgaa gtaggactgg ttctattaat tccgattgtc 3695581 tttgcgattt caagagaatt gaagatttct attttatttc tcggaatccc gatggtcgcg 3695641 gcactatccg tcacacacgg tttcctgccg ccgcacccgg gacctacggc gatcgccggt 3695701 gagtatggcg caaacattgg agaagtgctg ctgtacggct ttatcgttgc tgttccgaca 3695761 gtgctcattg cagggccgtt atttacaaag ttcgcgaaaa aaatcgttcc tgcatcattt 3695821 gcgaaaaacg gcaatattgc atcactcggc acacaaaaaa catttaacct tgaagaaaca 3695881 cccggctttg gaatcagtgt ctttactgca atgctcccga ttatcatcat gtcggtcgcg 3695941 accattatcg acctgcttca agaaacaatc gggtttgcag ataacggagt tttagctttt 3696001 atcagattga ttggaaacgc atcgactgct atgattattt cgttattggt cgcagtctat 3696061 acaatgggca tcaagcgcaa cattccagtc aaaaccgtga tggattcttg ttcaactgcc 3696121 atttcacaaa tcggcatgat gcttttgatc atcggaggag gcggcgcctt caaacaagtg 3696181 ctgatcaacg gcggtgtcgg cgattacgta gcagacttat tcaaaggaac ggcattatcg 3696241 ccaatcattc tggcatggct catcgcagcg atcctgcgca tttctctagg atcggcgact 3696301 gttgccgcac taagcacaac aggtctggtc attccgttat tgggccattc tgatgttaac 3696361 ctggcgttag tcgtactcgc aacaggagcc ggaagtgtca tcgcttcaca cgtcaatgac 3696421 gccggcttct ggatgttcaa ggaatacttc ggattaagca tgaaagaaac attcgccaca 3696481 tggacattgc tggaaaccat tatttccgtt gctggactgg gattcatttt attgttaagt 3696541 ttagttgtat gaaattaaga aggagctgta acacatgttc aattcgattg gtgtcatagg 3696601 cttaggcgta atgggaagca acatcgcctt aaacatggca aataaaggcg aaaacgtcgc 3696661 tgtctataat tacaccagag atttaacgga ccagcttatc caaaagctgg atggacaatc 3696721 tctcagcccg tattacgagc ttgaggactt tgttcaatcg ttagaaaaac caagaaaaat 3696781 ctttttgatg gtcacagcgg gaaaacccgt agattccgtc atccaatcat taaagccttt 3696841 gcttgaagaa ggcgacgtca tcatggacgg aggaaactcc cactatgaag acacagaaag 3696901 aagatatgac gagctgaagg aaaaagggat cggctacctg ggagtcggca tttccggcgg 3696961 tgaagtcggt gcgttaacag ggccttccat catgccgggc ggagatcgcg acgtctatga 3697021 gaaagccgct cctatcctga cgaaaatcgc agcccaagtc ggagatgacc cttgctgtgt 3697081 ctatatcgga ccaaaagggg cagggcactt tacaaaaatg gtgcacaacg gcattgaata 3697141 tgccgacatg cagctgattg cagaagctta tacgtttcta agagaaacgc ttcgtctgcc 3697201 gctagatgaa attgcatcta tttttgaaac atggaatcaa ggtgagctga aaagctattt 3697261 aatagagatt acagctgaga ttttacgcaa aaaagacgaa aaaacaggac agcctctgat 3697321 cgatgtcatc cttgataaaa ccggccaaaa aggcaccgga aaatggacga gcatgcaggc 3697381 gattgataac ggcatcccgt ccacgatcat cacagagtcc ttgttcgccc gctacttgtc 3697441 atctttaaaa gaagaacgga tggcagctca agatgtatta gcaggcccgg aagccgaaga 3697501 aaaacacttg gataaagaca cttggattga atacgtcaga caggctcttt acatggggaa 3697561 agtatgcgcc tatgcacaag gctttgccca atataagatg tcatctgagc tttacggctg 3697621 gaatctgccg ctcaaagaca tcgccttgat tttccgaggc ggctgcatca tccgcgctga 3697681 tttcctaaac gtgatcagcg aagcattcag tgagcagcca aatctggcta acctgctgat 3697741 cgcgccttat ttcacagata agctccatgc ctatcaaaca ggcctgcgaa aagtcgtttg 3697801 cgagggtatc agcaccggaa tctctttccc atgcttaact accgcgctct cttattacga 3697861 cggctaccgc acagggcgtt ccaatgcgaa cctcttgcag gcacagcgcg attactttgg 3697921 cgctcacacg tacgaacgga ctgatatgga cggcgtcttc catacgaatt ggtctgaata 3697981 acctgtatta aaaacacggt cagtttcaac tgaaccgtgt ttttttcttc tatcccaaac 3698041 aacagaagac ataagttatg ttttaaatat cataaacagt gatacaataa tagctagaaa 3698101 caatccccaa gatcatcatg tgacagcaga ttgctgttcc gttctattct gcttttggcc 3698161 attgtccttt gcccttgacc atggtgtcat aaaatgttca aatgccaaaa cggcctggca 3698221 ttctgattta caaaagtccc tgaaaacctt atctaattga gaatcagcct ctcatttatt 3698281 ataaaagaaa tgcctaaatc ctacctgtca cacctttatt aagatgaaaa aaagtaggtt 3698341 atggcttgac aaaaaatata tattaattaa taattcatat ataattagaa ttattattga 3698401 aagcgattat gctttctaat acatttttag gaggaatata cattatgtct ttaatcggta 3698461 aagaagtact tccattcgaa gcaaaagcat tcaaaaacgg tgaattcatc gatgtaacaa 3698521 acgaagattt gaaaggccaa tggagcgtat tctgcttcta cccagcagat ttctctttcg 3698581 tatgcccaac tgagcttgaa gatcttcaag aacaatatgc tgcacttaaa gaattaggtg 3698641 ttgaagtata ctctgtttct acagatactc acttcgtaca caaaggctgg catgacagct 3698701 ctgaaaaaat cagcaaaatc acttacgcaa tgatcggtga cccatctcaa acgatctctc 3698761 gcaacttcga tgttcttgac gaagaaactg gccttgctga ccgcggaaca ttcatcatcg 3698821 atccagacgg cgttatccaa actgttgaaa tcaatgcagg cggtatcggc cgtgacgcaa 3698881 gcaaccttgt aaacaaagta aaagcagctc aatacgttcg tcaaaaccca ggtgaagttt 3698941 gcccggctaa atgggaagaa ggcggcgaaa ctcttacacc tagccttgat ctagtaggta 3699001 aaatctaagg agtgcattca attggtactt gatgcaaata tcaaagcaca attaaatcaa 3699061 tatatgcagc taattgagaa tgacattgtt ctcaaagtta gcgcaggcga agatgacact 3699121 tctaaggaca tgctggctct cgttgatgag ctggcttcca tgtcatcgaa aatttcagtt 3699181 gaaaaagctg aattaaacag aacgccgagc ttcagtgtca atcgtgtcgg agaagacact 3699241 ggcgtgactt tcgccggtat ccctctgggc cacgaattca catcattagt gttggcgttg 3699301 ctccaagtga gcggcagacc gcctaaggta gaccaaaaag tcattgatca ggtgaagaag 3699361 atcagtggtg aataccactt cgaatcttat atcagcctga catgccacaa ctgtcctgat 3699421 gttgtacaag ctttaaacat gatgagcgtg ctgaacccga acattacgca cacgatgatt 3699481 gacggtgcag catacaaagc agaagttgaa agcaaaaaca tcatggcagt gccgaccgtt 3699541 tacctgaatg gcgaatcctt cggaagcggc cgtatgacgc ttgaagaaat tcttgcgaaa 3699601 atgggcagcg gcacagatgc atctgagttt gctgacaaag agccgtttga cgttcttgtg 3699661 gtcggaggcg gacctgctgg tgcaagtgca gcgatctaca ctgcacgtaa aggcatccga 3699721 actggtgttg tcgctgagcg cttcggcgga caggttctcg acaccatgag catcgaaaac 3699781 ttcatcagcg tcaaagcgac ggaaggaccg aagctagcgg caagtcttga agagcatgtg 3699841 aaggaatatg atattgatgt catgaacctt cagcgtgcga aacgccttga gaagaaagat 3699901 ctgttcgaac ttgaactcga aaacggcgct gtcctgaaaa gtaaaacagt gatcctttca 3699961 acaggtgcac gctggcgcaa tgtcaacgtc cccggtgaac aagagttcaa aaacaaaggt 3700021 gtcgcatact gcccgcactg tgatgggcca ttgtttgaag gcaaagacgt tgcggtaatc 3700081 ggcggcggaa actctggtat cgaagcagcg attgatcttg caggtattgt caatcacgtt 3700141 actgtactag aattcgcgcc ggaactgaaa gcagacgaag tcctgcaaaa acgtctctac 3700201 agcctgccta acgttactgt cgtgaaaaac gcacaaacaa aagaaatcac aggtgatcag 3700261 agtgttaacg gcatcacata tgtagaccgc gaaacaggcg aagaaaaaca cgttgaactt 3700321 caaggtgtat tcgtccaaat cggtctcgtg ccaaacacag aatggttaga aggaacggtt 3700381 gaacgcaacc gcatgggcga aattattgtc gacaaacacg gcgcaacaag cgtaccaggc 3700441 ttatttgctg ccggcgactg cacagacagt gcgtacaacc aaattattat ttctatggga 3700501 tcaggtgcaa ctgccgccct cggcgcgttt gattacctaa tccgtaacta atataagaaa 3700561 tccgctatat tgccagattg gcaggatagc ggatttttct ttttctacag aaaaaaaccg 3700621 aaccaggcac tacggtaaaa gtgctcgatt cgagcgcttc ttatagttcc tcaccattcg 3700681 tttgaatgac atttttatac cactcaaagg agtctttctt atatcgtttc atggatccgt 3700741 ttccttcatt gtcacgatca acatagatca tgccgtagcg ttttttcatt tcgccagttg 3700801 tgaaggagac aatatcaata atgccccacg gcgtgtagcc aattaaatca acaccatcgt 3700861 acgtgaccgc ttttttcaat gcttcaatat gcgattttaa atattgaatg cgttccggat 3700921 catgaacctt gccgtcctcc tccagcgtat ccactgcgcc aaagccattt tcaacgatga 3700981 ataacgggat ttggtatcgg tcataaaaac gatttaacgt atatctcaac ccggttggat 3701041 caatcgccca tccccagtca ctcgaagtga tgtacggatt ttcgacacca ttcggcaagc 3701101 cgccatttac aatatcgcca gtgttatcat ttttcacatc gcttttcaca gttgttgaca 3701161 tgtaatagct gaagcctaag taatcgacgg ttccgtttct taaaatctca tcatcgccgt 3701221 cttcgaatgt gatgttgtag ccttcgcgtt caaattcctt caacgcgtag cttggataat 3701281 aaccgcgaac ctgcacatca gggaagaaat agcgctgcct catttcttct tcagccagca 3701341 tcacatcttc aggattggag gagaaaggat aaatcggcac gtgtgatacc atggccccaa 3701401 tctggaactc tggattgatg tcttttcctt ttgccactgc taaggcgctc gccactaatt 3701461 catggtgcgc cgtttgatac atgacttcct tggcgttttc gttttcgcca accacaacac 3701521 ctgaattcgt ccataggaac agcggattgt tcacatccat ttggttgtta atctcgttaa 3701581 atgtcatcca gtacttcact ttatctttgt aacgggtaaa gcaagcctct gcgaagttga 3701641 cgaagaagtc cacgactttc cggtttctga agccgccata ttctcttgcc aggtgcagcg 3701701 gcatttcaaa gtgagacagg gtaatgaccg gctcgatccc atgcttcagc aattcatcaa 3701761 acacatcatc ataaaactgc aaaccagctt cgttcggttc agcctcatcg cctttcggaa 3701821 aaatccggct ccagccgatg gacgtccgca gacattttaa tcccatttcc gcaaacaaag 3701881 cgatatcttc cttgtatctg tgatagaaat caatggcttc atggtttgga taaaattcgt 3701941 tttcttcaat cgtgtcagtg atttttctcg gcacgccgtg cgcacccgct gtcatcacat 3702001 cgacgacact cggcccttta ccgccttgat tccatccgcc ttcaaattgg tgggcagcta 3702061 aagcaccgcc ccataaaaaa tcctttggca tgtttcccat gtttaattcc tcctcagctt 3702121 acgactgtaa atattttttg atgtaatgca ctttcctcaa tgtcttcaat gaaagcttta 3702181 tcaaactcaa caagcacttc gccttttttg acggtatcgc cttcttttac cttcaaggaa 3702241 aaaggcgtgc cgtcaaatgt caccgtatcc agcccgatgt gcgcaagcaa ttcgacgccg 3702301 gacgctgaac gcaggccaat cgcatgcttt gtaggcgtaa ccatgacaac cgtaatgacg 3702361 ccgggatggt agcatcgatt tcacgatatc cttcgcttta ggggtagacc gcttcagcac 3702421 caatcgaagt ctggtagcgc agcgagaagc cccaatcaca ttctcttccc cgcctacggc 3702481 ctctaaaatg tcttttgcta gtctcgtata atctctcact ttccccgaca tttcacccac 3702541 cccttcgttt tggttacgct ttcattataa ttgtaacggt ataatttatc aattccgaaa 3702601 caaaatattt acgcactaac tatcattgta agcggtttat gctataattt tgacaagtga 3702661 aactaaacga ataaatgagg aatgcgtatg ttaaaatacc agcaaatcgc aacggaaatt 3702721 gaaacatata tagaagaaca ccagcttcag cagggagaca aactgccagt cctagaaacc 3702781 ctcatggccc agtttgaagt cagcaaaagc accatcacaa agtccctcga gctattagag 3702841 caaaaaggcg cgatctttca ggtcagagga agcggcattt tcgtcagaaa acataaacga 3702901 aaaggctata tcagccttct gtcgaatcag ggatttaaaa aagatctcga ggatttcaac 3702961 gtcacctcaa aagtcatcga actggacgtg agaaagccaa caccggaagc ggcggaaaac 3703021 ctgaacatcg gaatggacga ggacatctac tatgtcaaaa gggtccgcta catcaacggc 3703081 cagacccttt gctacgaaga atcctattac accaaatcca tcgtgacgta tttaaacaac 3703141 gaaatcgtct cccactccat cttccattac atccgggaag gactggggtt gaagattggt 3703201 ttttctgatt tgtttctgca cgtgggccag cttaatgagg aagaagcgga atatttggga 3703261 ttagaggctg gactgccgaa gctgtatata gaaagtattt ttcacctgac aaatgggcag 3703321 ccgtttgatt actcgaagat ttcgtataat tatgagcagt cgcagtttgt ggtacaggct 3703381 aatagttttt tattataggg ctcttcacta cggtaggtgg tcgacatgta caaaattatc 3703441 attcctgcca tactagccat ctttgcgctc tggatactct tacagatttc actagagatg 3703501 agcatcgtta agaatccaat gaactacttt atcgtattca ttatcttttt cctctttgta 3703561 aagatggtga aagaaaaaca ataatagttt gggcgatgca aacagaaaaa catccttccc 3703621 ttaacaaact cagccagtca catgcattaa tcttgatgtt aatgatatat aggtgcacat 3703681 aaaaagctac ttcattgtga agtagctccc tttattaaag gcccattttg atccatctag 3703741 ttttagaaaa gcgaaggaca atcgcattta tgataataat tgaaactaaa tacaaaataa 3703801 taaataaaac atcattactc ccaagtgtca tgttatcaga ttgcagcact ctttctattc 3703861 gggggtacat agtgttacct gcctcaaaag gagcaatgaa accaaacgtt ttattgctta 3703921 tagctactaa gataacagaa gtcatccaat aaacgatact gacacctata ctaattaata 3703981 tattaggaca taacacgctt atagttccga taattagaat atactgcagt ataactgcag 3704041 aaaataaaaa aagtaataat gcaaaatgcg aaaaatcatg gtacatcaac gatatgatta 3704101 gcaggcctag cgttataaat gcaaaacatt ctaaaaataa aacagctatc tttttataaa 3704161 agaaagtata gatgttctct ccaattaact tgtaaaagag aatatttttg tttgaatact 3704221 ctctattaat aaagaaagct ataacaaatg aaaataacat caaaccaaac tgggtcgcaa 3704281 cagtatagga gctaaagaaa aacatttcag gtgtaacatt actgacttta tcgattccaa 3704341 caagtaaaaa ataacccagc aaaaataaaa atacaaacat tgctcctaaa ataatgataa 3704401 ctttgttgct aatactcttt ttaaactcta atttcatctc aagcccccac tgttttatta 3704461 ctcatttata tacacttcaa ttaatttatc cactgaatga tattgttgaa tttcttggtg 3704521 attaaatata taataatccc cttctatcgc ctttaaatca gacaaatcat gtgtaatgtt 3704581 gatgataatc ttctcggggt tctcctgaat atacttgttt aagaagccat gaatctctat 3704641 aaccgttttt ttgtctaatg aattcgttat ttcatctaaa acaataatat ttttatcctc 3704701 taataagaaa ctgagcaatt ttaatttttg cttttgtcca tcactcaaat ttttgatcag 3704761 aacttttcca tcaatattat ccagattaag taaatatgcg attttatcta tcatttttgc 3704821 atcaaatttt ttactcaaaa agtgtaataa aaagtcctta gaaacatcat taggtatatt 3704881 cgacgagctg gatattaaag aaacattttg acgaatatct ctgccgattc ttttgctatt 3704941 attcaacaaa aagtctttag caagctgtga tttaccgact ccattttttc cgacaacgtg 3705001 attaattttc ccgctcgaaa aatgcaagtc ggtgtcctga agtaacgttt tgcctttcac 3705061 ttttaaagtg taattcgcta tattcatata catactccta ggaaatattt gcataataat 3705121 aaaatgttct gccttgtgat ttgttactaa tgtctaagct tttgaggtac ctctttcgtt 3705181 tccgatccgg aagcgaaaga aatgttttta gatggctaat ttggagatct tttactctag 3705241 tttacaatat ataatatcca atgtacaact gaattcactg caaggccaat ccctataatt 3705301 tgaatcgtaa gaactaacca atgatttgtc ttaaaacggc tatattcatc taagctcaga 3705361 aaagctaaaa gaattttgta accatcagaa ttcaatattg ggattaagtt ccacaataaa 3705421 gtagacgaga aaagcataaa tgccatagtt aatgcttcac tggaaaatgt aaattgattt 3705481 attaattcta atgtatttat taaaagataa ttgataaaca agccaaataa atgaacgatt 3705541 atcttttcat ttcttgatag catgtaggtt tcattcaatt ggacataaaa agcaggaaat 3705601 acataaaaat tcagtttgaa tcccacttta tcaaagtttt tcccgaaaaa ttttaaggaa 3705661 taaatatgtc ccagttcatg aagcactata ttcattataa aataaataac tataattatc 3705721 cacattttcc agccgtaaaa tactgaggac aatccatttt gcaattttat taaatgaata 3705781 taatttaata tgaacatgag agccgtaaag gataagaaca gataaaaaaa ctttggtgat 3705841 actttctctt tatacatttt aaaacgtaat aattgtttat ctgacagaga atttaaacta 3705901 tttttatagt attctccgct ttttttgtct tttataaata cgttgttttg cacaagcact 3705961 tcatattttt catcttcata ctttaaaatt ttcattatag tatttttcca tataaggata 3706021 gaagtagttt attttttctg cagagttgaa taaggaacca caaactccac aaatagagga 3706081 aaattcataa ggaatgtcaa attcctctat tttgttattt tcttttaaaa tattcaaaaa 3706141 ccatttgaat ccttcttttc taagaataaa taatagcaaa ttggaattta acttttccac 3706201 ggttctttcg aaactttggt tatattcttc ccttagggtt attttcgttt caaaaatagc 3706261 aggggaacaa catggataaa tttctccatc atgatgatat acaatgtcat atccgggaca 3706321 atgtaaggaa tcttcatctt caagactgta aaatttatgt atgttttctt gcttaattct 3706381 agttttagca gcgccaactg atatcattgg aaattttgtt atctttacac ctaagattga 3706441 atcccccaat tcctctaaaa tgtggttgga cattttgtct ttggtaactg ccatattaag 3706501 agaaatatcg atatcagggt atttcctgct atgttctaat atgtttttaa tactggaaga 3706561 cttgacaaat ggagcatggt actcatcata acttatagtc agtgctatca catttaaaga 3706621 attcatatca tgaaagtact cctggacctt tttcttgctc aaaccccaaa atccattaga 3706681 gatcaacgtt atttgttttt catatggttt aatgatttcc attagttctt ttaaaaattt 3706741 ataatctaaa aaaacttccc cacctgtaaa agaaatcact tgaatggttt tgttttttgc 3706801 aaattcagtt actaactctc ttatgtattc tttttccatc ctggttgttg aagttggtga 3706861 actagaaaaa caacaatggt cacaggatgc attacacctt gaatctaaat tgattgatac 3706921 tgttttatta tacatgaaat atcccccaac aaatggtaaa ggagagttag actctccttt 3706981 gtacccctct aattaatgac cacttccaag aatccagcga ttttcttttg attttacaaa 3707041 ataccaaaga tcattcactt ttgctaactt ttgtgattca tctaatagac ccttaaattc 3707101 taagtttttc acagtctcat tgttagtgat ttcctttttc atattatccc tcctcctttt 3707161 ctaatataaa ccaattattc tatatcattc aatacatgtc aatatattgt acctaaaaaa 3707221 tctgaaaaat gtcactattc ttggtatata aagcctatag tcctctagcc cctctaagct 3707281 ataccgaatg aaaggccata gtttgattta aagcttcgta atgaaaagta aaacatcaat 3707341 attgactaca ctagttaagg gatatacaga ttttaagtgg aagaaatgag gcaaacaatc 3707401 ttaccctaaa ccaacctgta ctgaaaagct gttttaagct cttgcttacc ccatttggca 3707461 cctctttctc tcgttttaat tgtctctaaa agcagttatg cggtactatc atataaaggt 3707521 ccaatgttta aaaataatgt catactttta aattcacctt atcatgcaca tgctcataaa 3707581 gaggggttta ttctaaaaag gggatggacg gttttggaaa gcaagtacct agatctactc 3707641 gcacaaaaat acgattgtga agaaaaagtg gtaacagaaa tcatcaattt gaaagcgata 3707701 ttgaacctgc caaaaggcac cgagcatttt gtcagtgatc tgcacggaga gtatcaggca 3707761 ttccagcacg tgttgcgcaa tggttcagga cgagtcaaag agaagatacg cgacatcttc 3707821 agcggtgtca tttacgatag agaaattgat gaattagcag cattggtcta ttatccggaa 3707881 gacaaactga aattaatcaa acatgacttt gatgcgaaag aagcgttaaa cgagtggtat 3707941 aaagaaacga ttcatcgaat gattaagctc gtttcatatt gctcctctaa gtatacccgc 3708001 tccaaattac gcaaagcact gcctgcccaa tttgcttata ttacggagga gctgttatac 3708061 aaaacagaac aagctggcaa caaggagcaa tattactccg aaatcattga tcagatcatt 3708121 gaacttggcc aagccgataa gctgatcacc ggccttgctt acagcgttca gcgattggtg 3708181 gtcgaccatc tgcatgtggt cggcgatatt tatgaccgcg gcccgcagcc ggatagaatt 3708241 atggaagaac tgatcaacta tcattctgtc gatattcagt ggggaaatca cgatgtcctt 3708301 tggatcggcg cctattccgg ttccaaagtg tgcctggcca atattatccg catctgtgcc 3708361 cgctacgaca acctggatat tattgaggac gtgtacggca tcaacctgag accgctgctg 3708421 aacctggccg aaaaatatta tgatgataat ccagcgttcc gtccaaaagc agacgaaaac 3708481 aggccagagg atgagattaa gcaaatcaca aaaatccatc aagcgattgc catgatccaa 3708541 ttcaagcttg agagcccgat tatcaagaga cggccgaact ttaatatgga agagcggctg 3708601 ttattagaga aaatagacta tgacaaaaat gaaatcacgc tgaacggaaa aacatatcaa 3708661 ctggaaaaca cctgctttgc gacgattaat ccggagcagc cagatcagct attagaagaa 3708721 gaagcagaag tcatagacaa gctgctattc tctgtccagc attccgaaaa gctgggccgc 3708781 catatgaatt ttatgatgaa aaaaggcagc ctttatttaa aatataacgg caacctgttg 3708841 attcacggct gtattccagt tgatgaaaac ggcaatatgg aaacgatgat gattgaggat 3708901 aaaccgtatg cgggccgtga gctgctcgat gtatttgaac gattcttgcg ggaagccttt 3708961 gcccacccgg aagaaaccga tgacctggcg acagatatgg cttggtattt atggacaggc 3709021 gaatactcct ccctcttcgg aaaacgcgcc atgacgacat ttgagcgcta tttcatcaaa 3709081 gagaaggaaa cgcataaaga gaagaaaaac ccgtattatt atttacgaga agacgaggca 3709141 acctgccgaa acatcctggc agaattcggc ctcaatccag atcacggcca tatcatcaac 3709201 ggccatacac ctgtaaaaga aatcgaagga gaagacccaa tcaaagcaaa cggaaaaatg 3709261 atcgtcatcg acggcggctt ctccaaagcc taccaatcca caacaggcat cgccggctac 3709321 acgctgctat acaactccta cggcatgcag ctcgtcgccc ataaacactt caattccaag 3709381 gcagaagtcc taagcaccgg aaccgacgtc ttaacggtca aacgattagt ggacaaagag 3709441 cttgagcgga agaaagtgaa ggaaacgaat gtgggtgagg aattgttgca ggaagttgcg 3709501 attttagaga gtttgcggga gtatcggtat atgaagtgag gggtgtgggg ttcagggatg 3709561 gtgatatgct gctcccctaa aagtagatag atgaatttta gaaaatctgt ttgccttggg 3709621 gagttttttc atggctggac aattatacta caaggaagaa atactaatac ttatagaatg 3709681 taattgggta atgattcgga gaaagaggtt gcgaaataat atggtattac actgaaacaa 3709741 ttatcaatgg agaacatgca cgatatagcc gttctatatt ctccctctat tatggcactc 3709801 attagtagac ataaccgtaa aaaaatgcac tcaaaaaaag tccattctat ataactctcg 3709861 ctagggtgga cctttttcaa cattcaaagt actagatttt ttctagtgaa agaataagaa 3709921 aagacataag ttctatttta tcactctgtt ataggttaag ttattacggt gtttcattat 3709981 atactgaatt taaacaccct tgacattatg ggaattttta aaacaggtta aaaggaagtt 3710041 ctataagaac tccctagttt aatattattt ggtcaaaatc taaaaccaaa aaatctattt 3710101 ttatcttcat tgtttctatc taattttgca acaatcatac ctttcgactc taattcttga 3710161 aggtcatcta ataataattc atttttattt attgttacaa aatattgtcc gatcctattc 3710221 tctaacagac ttgaattgat atgttttaat aatgtacctt ttacatgagg atcaggatta 3710281 gaataagatc cgtcatgaat taaaatattc aaactacact tatttataca cctgtataaa 3710341 aaccaagtaa gatcaaatat atttatcttc atatggagtc taccatgtga acgttcatcc 3710401 ggtatagaac aagaaatttt gatccttcct gtagttgatt gttttgcgtt acttattcta 3710461 ttatcatatt caaaatctaa aaatccatgt tggttgtatg taacatccat tagattatta 3710521 aaaagcttct ttaactcact aactatagcg ctataagatt gaaactcatc ataatacatt 3710581 gaattaactc ttaatatttc atgttgaagt tcattaatct tatcaaaaat atggtttttt 3710641 ttatcgtagt cactaattct caatcttact tccgctaact ctatttcttt ccttctttgt 3710701 tcttccatca caatggaaat atcctcaatg aaattgttac tctttaaaat tctggcactt 3710761 gattccagtt gttctgttaa tccttgcttt ttgatattaa gtttttttaa atcggcttgt 3710821 attttaacaa ttttatcttt aaaataactc cctctacttt ctaccatgaa attatagaac 3710881 tcttggactt tattataatt ctgttttact tcctctggaa aaaaacctac aatatcttca 3710941 tagaattttt ctatattttc taattcttta atcttagtta cttttttatt taaatcatct 3711001 atatttcttt gatattgttt acaaatatgt tcattttcaa atatttcatt ttgtatttta 3711061 ttaagttcac ttttaatttc tgagtaccta tttgtatcat tattatattt attggcagtc 3711121 ttagtttgat agataactct attgtaatcc tctatctcat ttattaattc atcttcctta 3711181 acttttaaat cgccaatgtt aatattcatt gattcaatca attttatttc actatttaat 3711241 ttttcaatct tatcccgaaa aacctttatg tttttttctg tatgagttgg taaagtaaaa 3711301 agatagttaa gtaatttata ttgttttaac cctcccctat tcggtaaaac tatatcatta 3711361 aaccctgtct tttcgtctct tataatatac tcccttaacg ccgcaaaagt tatatcctct 3711421 ttctcaccct ttaaaatttc cttttcaata aattttttat atacacttat actaactttt 3711481 ttccattcct ccaaattaaa agttaaagaa gtatcatgta atgtataacc atgtttagga 3711541 gaattaaaag atctagcaag gaatacttga tttccatcaa tttccacatt caaaacaata 3711601 aaaacgtttt tattgagaag aatttcattt gtcgtataaa aatttgatat agtcttccct 3711661 agtaaaaagg agatgcattc aatcatcgtt gacttaccta caccattagt ctcttcatga 3711721 tcttctctct tttcaccaag tattatattt actcctacag cattaaattt atactctttc 3711781 aaaatttctt gggaattgca aacaaaaaga ttttttataa tcataacaat cactaactct 3711841 ccgttctgct aatcatattt tgattaaaag aaactttacc taatgaatat aaaaaagtta 3711901 acgataaata cagtatccgt tcaatattca aatttattat aataccttga ctcttagcat 3711961 aatcaagaaa aagttgatca atatgttttt ccttctctaa cagttcataa agtatctttg 3712021 atgagtataa aatattttct tccacagcat tatatttagt taataaaaaa tgattcattt 3712081 ctggcctctc cgccttttcc ttttttaaag gagaattatt cactagagga ataagatcat 3712141 ttccaatttg aatgttttta aactcatttt ctaataaaac ataagagtat ttgagaatat 3712201 tttcagctgt ttcaatttta agatcaatca ttcttaacac ttcttttgtt atcattaaaa 3712261 atctcacatt cataaatgca ccaacatgtt aaaatcttaa tgtatttttt cgttaaagcc 3712321 tttgaatatg gtaaaactga atgacattct agataaatct cattaacaat ttttacaaat 3712381 atctcatctc cattattata ttgattatga aactctagat atttgtctac tatcgtctca 3712441 gcaatcaatt cctttttatc agcacttaca tacgaagtgg aatccattat atggtttatc 3712501 acaccaaaat actcagaata actatcgaat ttccgtttaa aagtttcccc acttttcata 3712561 tcataaaatt ttttatctaa accaatttga ttatcaaaat tactagtaaa tgttttataa 3712621 ctttctctat actcatgaaa atctataata aagctcttaa actcatcttc atcaatttta 3712681 tcatcgttat cttctatttc tttttcaata aggctctcta atctattaat cttataattt 3712741 aacttccctt cctgtagtct ccttcctcct tggttgtttt ttgaccagta tttatattcg 3712801 gtattccaaa tgtagtatgt tacttctgtc tcgccattat ctaaattcac atccaccgaa 3712861 ataaattctg gagtagcata ctcatccttt ataatggctc cacttactaa ttctaagaat 3712921 ggattttcat ttgtatttgc agtaatatta aatgaagaat catgtacatg tcctgccaaa 3712981 tatagatcaa taaagtaatc atcaaaatgt gcctttattg attctctttc ggaagattca 3713041 atacaaccta acgtatggtg cccaatagct atatttaata ccttgccctt atttttctct 3713101 ttgttcatct tccttattgc tttatataat ttcatctgtg cagttaataa cgttccttct 3713161 tcaccttttt tatctgataa cagacatgta tttattgata aaacattata cttctccgat 3713221 tgatacaaaa aatgcaaatc ttcttccgga tatttaacac ccataaaatc ttcataaaaa 3713281 tcgaaaaatt tcctttgacc ttccactaat atatttgtag ctttttgatc tagtttatcc 3713341 aacatttctg aggggttagg agatttcata atactatcaa tcaaaagtgt cctcgtcatg 3713401 tctctagata tatcgtgatt tcctggcact aagtgtacgt tattcttact taatcccata 3713461 cttttaataa ttccattaag atattcttta acatcttcgt tatacacatc acctttgtgt 3713521 gctatatctc cagttaataa taaaaaatca aaatctgact ctcttcttaa aacttctata 3713581 aaatctaata atttatctct cattacaata gtgtcataat tttgaaactg aaaatgcaaa 3713641 tcagaaattt gtaaaaaacg taccttcaat acaaacatcc tctcataagt atatttatcc 3713701 cctatatatt tctagaaaac tttttattct atatcatctt tactctttaa tatattaaga 3713761 ctctttccac accatcaaat aaattataac ctaaacataa ctctttactc attttagtat 3713821 tgtatttaag tcaaacattg cattggttgc tgaaatatta tattcattga attattccat 3713881 taaatagctt ttagttgaac tttagtcttt ctgtaatggt ggagatgctc ttacttatga 3713941 taaggctccc cacgattaat ccgaaaagcc cgataaatct gctccactaa aataagccgc 3714001 atcaactgat gaggaaatgt catcttcgag aacgatagct tctcgtccgc tcgcttcatc 3714061 accgtgtcac tcaatccgag tgatccgccg atgacgaagg tgactttgct ttttccataa 3714121 gtagccagct tatctattgt atcggctagt tcttcggatg ttttcatttt tccttcgatg 3714181 gcgagggcga tgacgtgggc gtcggggctg attttggata ggatgcggtc gccttctttg 3714241 tcttttatga ttttcatgtc ctggtcgctt aggttttccg gcgctttttc gtccgggagt 3714301 tcgatgatgt cgatttttgc gtaggccgaa agtcgtttgg tgtattcttc aatgccttgc 3714361 ttgaggtatt tttcttttag ttttccgatt gtcacaatat tgatattcac aggtcatccc 3714421 cactttaaaa acaagttatt catatatgtt gtccacaatt gtggatatct tttctgtatt 3714481 ttgtgtaaga tcattcgttc cccactatat atactgcggg gtctccacat aattcacagg 3714541 ctgtggataa actgttagta tgttcgattt ttctgatttc gggcggcagc tcgtggtcgt 3714601 ctatgtacat atccagcacc gtttcgatgt gttcttcaca agaataatac gcttgtttca 3714661 tgttcaaatc ctccgatgtt ttcttccatt tttacaaatg ttctcttctc aatataacct 3714721 atttattcac atgttagtag tgcttcgggc tgagttttat ccacaattcg acaaacaagc 3714781 tgttgatgac tctatttcgc tcgtgtgtta gtttggatgt aaccgatgtg tggggaggtc 3714841 tgcatttgcg ctttagatgg gtttggcttt ttgtgattat gttgctgctt gctgagtgtc 3714901 agccatctta ttgggtgttg gagaaggatc gaatcggtga aggcagtcca gacttagaaa 3714961 tatacgctaa ttatctccaa atgcatgatg acgtgaaagg atatcaagtc ttcaccatat 3715021 cagaaggcaa aaaaatggtc gtcgtgtctc tcggaagcag cgagaaagat aagaagcttg 3715081 aagtgtcgga cgtcaaattc tcatctaaag aaacgattgt aactgtggag cgaaaacctg 3715141 ctcctacggc aaatgagaaa aaccctttta ttttgattgg actggacaaa attgaagggg 3715201 atttaattgt tcaagacgaa acaggagatc gctttgaaga aacggattac cagcaataaa 3715261 gccggcgttc tgagaacgtc cggctttttc ttttacttca atgtcccatg cgggtcgatg 3715321 acgaattttt tggctgcgcc tttgtcgaag tcgctgtagc cttttggcgc gtcgtccaga 3715381 gaaataacgg tggcattgac ggcttttgcg atctgcgctc tgccgctcag gatcgctttc 3715441 atcaaattgc ggttgtatgt catggcgggc gtttgtccgg tgacgaaggt gtgggctttg 3715501 gcccagccga gtccgaagcg gatttttaat gagcctgttt tggcgtccgc atcctttgca 3715561 ccgggatctt cggtcacgta taagcctgga atgccaaggc tgcctccgac ctgggtgacg 3715621 tccatgattg agttcagcac ggcggctggc gcttctcctt gattgccgtg cccagatgct 3715681 tcaaagccga cacagtccac tgcagcatca acggttggtt cacctagtat ttgttcaatt 3715741 tgctcgccga ggcggtcgtg tttttgcacg ttgaccgttt cacagccgaa gcttctggcc 3715801 tgtgccagcc tgtcttcgtt cagatcgccg acaatcacgg tagaggcgcc taggagctga 3715861 gcggagtgtg cagctgccaa gccgacagga cccgctccag cgatataaac ggttgaacct 3715921 gtttgcacgc ccgctgtata agctccatgg aagccggtcg gaaaaatgtc ggacagcatg 3715981 gtcaaatcga gaatcttttc tagcgcctgt tctttatcag ggaataccaa aagctgaaaa 3716041 tcagcgtatg gcaccatgac atattcagac tggccgccga cccagccgcc catatcgacg 3716101 tagccgtaag ccgatcccgg ccggtccgga ttgacattca ggcacacatg cgttttctgc 3716161 gttttgcaca tcacacagcg tccgcaggca atattgaaag gaacggatac gatatctcct 3716221 tttttgataa attcaacatc acgccccgtt tcaatgactt ctcccgtaat ttcatgcccg 3716281 agcaccaagc cttctggcgc cgttgtgcgg cctctgacca tatgctggtc gcttccgcaa 3716341 atgttggttg taatgacttt gagaataacc ccatgctcac attttcgatt cacattcgcc 3716401 ttcgggacgc cgggcccgtc cctcaagatt aactccggat aaccgatatc ctccaccgct 3716461 acagtccctt tgcctttgta cacaaccgct ttgtttcctg tcaacgccat tcctcccatt 3716521 catgtgtttg gactctccgt ccttgaacat gacttcggtt cggcatgact ctttcccttt 3716581 ttcacgactg ttttttctgt attcttacaa caacaaatat gccaagaaag catccaataa 3716641 tggttccgcc gatgtctaag aagtcgactt tacatccatt taacaagaac acagtaatgg 3716701 ccgaaaccag gcagatcata actgccagaa gaataacccg atttgtctgc atgtaattcc 3716761 tcctttggat tcgtttctaa accataccca aaatcctctg caaacttcgg ttcaacaaaa 3716821 aaagagactt cacaccagtc tcttcataaa cagagatcac tcaaaaaatt tcctgagaaa 3716881 taatgtggca acactcgtta ctaacgcaat tgccgtatac ataacaaccc aaaatatgaa 3716941 tgagctattc cccgaagcta acgtaactaa caatatcaag ctcgtgataa gaacgatgag 3717001 cggtgccacc caaaatcttt taaataaaaa atgacccgct ataccaaata cacctgcgac 3717061 gatcggaaaa ccaaaaacga taaataaaac ggcgatggct cccatactac cctccttgcc 3717121 ttaaaacctc ttcatcacct caacatcata cagcttcaaa tgactcttcg gcgtcacgac 3717181 atcctttacc ttcccaatct ctttttcttt cattttcttt ccggttttca ggctgtactg 3717241 ttcaatgtag gcaggcttgt gatacgtgta tgtgaagaaa tagaggctgc tgcctttttg 3717301 ggtgatttct ttgaattcgg ctttcatttt gtccggggaa agggtgaaga cgatgcttgt 3717361 ttttcctgtc ttggcatcga ttttgtgtac ctttccgaag ccgtcaatga aatacaggtt 3717421 cccgtcataa gggaaaaagc tgtttttaaa gctgaagggc atggagctgt atatcgtttg 3717481 ttcgtcgttt ttgtattcgg cgatatcgtg cagctctact tcgccgcttt ttttgttgat 3717541 cttgaccatt tgatagagat cgtgggcttt ttggccgcga accataacat acacagcttg 3717601 gtcgtccacg gcaagttggg attcgactga ggctccttcc cggtactgcc attccgttat 3717661 gctgagatag gtaagcttct tctgatctgc ttgaatctga aggagctgat agccttttcc 3717721 gtcatctgtc gggacgagtg cgtaaatggc gccatcatgg aaaccggagg ctcggatgta 3717781 gtaggggatg acgtcttttt tccactctcc gtccatttgg cggtacagct ctgagcggta 3717841 tccgtctccc tttttgtcgt agccggagtt gtataaggtg taaaagccgt ccgtgttttg 3717901 cagaaagccc gcgctgtcgc ctgtgtgctg ataggttctt ttatgggagc gcaggccgtt 3717961 tttgatcgta taaatcgtgt ttttgtcctc cagcatcacg ctgtcaccgt gaacctttgc 3718021 tgagcccagc tcaaggccct tcatctgaaa ggaagacagc gtcccgtcat ggctgataaa 3718081 cagggcgtag cttttcccgc cgccaaatgc atcttgatcc gcagaggatg agaaatacag 3718141 caggacttct ttgtcatcca ggaaatcggg atttctgaga tcctgctgac tcacggtttt 3718201 atggcttttg agaggagaaa tgaagacaaa tagtgcgatt cctgcgagaa tcagcatggc 3718261 gatggtaatc atccactttt tcatagcctt ctccttagta aatggtcata atggttgtcg 3718321 tataagaaga actagtgatg tcgcgcggat acacgcctaa gcctccgttg ctgtctatat 3718381 caatccctgc tttcagcaaa aaggcagacc ataggagctt tgaacagttt ttggcgccgt 3718441 catggccggt atttctgtta ttgacgaagt taaatgagta tgggtcgccg acttttgata 3718501 ccgcccagtc ggcagcagct gttttttgag atgaggatac gctgacggtt tgcacaatgg 3718561 agttgtcttc cacgtctctg gcattatacg cgatctgcct gacgccgtcg ctcgggacag 3718621 attcaacaat tttgtcagcg gcggagtaca tgccgacatg gccgtgattg tagtaggctg 3718681 tgtaggagtt cgtgtaatag atattgcctt tcgcgcttgt cgggagtttt ttcgtgccgg 3718741 acgagccgcc catgatagac atgccgcttt ccttggcgag ccggtccccc tctgctttat 3718801 cagccgtgat ctccttatag aactgtttta ggataacgtc ctgctttacg tgctgctgtt 3718861 tggcaatctg gctggcagat ttcatgattt cttccggtgt cgtgcctggc tgcagtgcgg 3718921 cgatttcttc agcataattt gtggtcttta cggctttggc gggagtaaca aacaggccgc 3718981 cgcacattgt gagcgctacc aaaaacatcg acactcgttt cttcaacttc attacatctc 3719041 ctcttttctt gtgagtgtag gaaaggtaat ttcctcaccc acattatatt aggaaaataa 3719101 ggaaagtaac taggttattt acagaatttt tagaaatcgt ttacagaaaa aggcctttat 3719161 caggcccttt tcgttaaagc ttcttgctca tcactacgtc tgtttcttga aatccggttt 3719221 gctcatatag ctttcgagcc gtctgattat gggcaaagac atgaagggac agcttgcgga 3719281 ttcccatact gcgtgccgct tgatctaatg ccgccaatgc ttgctttgcg tagccctttc 3719341 cccgatacgg ttcatataac ccgaaatcat aaataaacgc ttcctgctgc ggatgctccg 3719401 gttcagcatg tatccagagc cagccaacga tatccttttc attcagcttg aggctccaca 3719461 aatggtgatg gggtgtttcg agccctctcg gaagcagatc agtaaacacc tgcttagaca 3719521 aaagctgggc atcttcaggc agccatgttc ccgcttttac cttttcttcc gcgtaatgct 3719581 ttgttgtgta cgtgagataa gaccgaaatt cttctgtctg cataggggtt agcataattg 3719641 tcatatcatc tctccttcat atattgacta gaggatttta cataaaatag aaagaggtgt 3719701 tactatcaga ataagcaact gagattgata agtcactaga gaaaggagtt tcacatgaat 3719761 aagatcgcac ccgcagaaat cgctagcatg ctcaacgatt ggtaccttgc catcaagaaa 3719821 catgaagttg aagaatcctc ccgtttattt gaagaagtga agcctttatt ggatgacatg 3719881 gaagaggatc aggaggtgct tgcctacttc tccttattgg aactgcgcca caaggttttg 3719941 cttcacgagg cgagaggaca gggctttcag catgaggagc cttctcatat gaatgctacg 3720001 tctgacatgc tgaaatatta cttttttctg tttgaaggca tgtatgaggc ctataaaaat 3720061 aattatgaca ttgccattgg gctgtataaa gatgcagagc agtatctcga caacattccc 3720121 gatccgattg aaaaagccga atttcacctg aaggtcggta agctctatta taagctggga 3720181 caaaatattg tgtccctcaa tcatacacgg caagcagtca aaacattcag agaagagaca 3720241 gattataaaa agaagctggc ttcagccctg attaccatgt caggcaattt tacagagatg 3720301 agccagtttg aagaagctga ggcttatttg gacgaagcaa ttcggatcac gagtgaatta 3720361 gaggatcatt tttttgaagc ccagcttttg cataacttcg gccttctaca tgcgcaaagc 3720421 ggcaaatcag aagaagcggt ttcgaaatta gaggaggctc tacagaacga tgagtatgcc 3720481 cgctccgcct attattatca ttctgcctac ttgctgatac gagagctgtt taagatcaaa 3720541 aagaaagaac aggccttatc ttattaccaa gacgtgaagg aaaaattgac tgctgagccg 3720601 aatagaatat gtgaggcaaa aatagacatt ttatatgcca tttatgcaga agggggtcat 3720661 gcggaaacgt ttcacttatg caaacaacat atggatgact tgttgtccga gaaagagtat 3720721 gacagtgtaa gagaactttc cattttggct ggcgaacggt atagggaact tgagctttac 3720781 aaagaagctg cccacttttt ttatgaagca ttacagattg aagaactgat taaacgaacg 3720841 gaggttatat aaatgaaaag atttctgatt ggcgcaggcg tcgcagcggt gattttatca 3720901 ggttggttta ttgcggacca tcaaacccac tcacaggaaa tgaaagtcgc tgagaaaatg 3720961 attggataaa tgaaaaaccc ccgcgggatg cgggggttca atttaacgaa agaatcctaa 3721021 aacggtttgt agttttagga ttctttcatc ttttcagcgt gattgaaaac ccttgaagtc 3721081 taggaagaac gagcattgga gcgcagcgaa tgtttggaat tcgtgagcac cgaagcgcag 3721141 gcctgacaac gaatgcgagg gtttgtcgac acgctgaaac ccccgcgggt gcgggggttt 3721201 tcttattaca gcagcttctt ccctaacagg gattctacga gctctactgc tgttttgccc 3721261 gttttgtttt tgtgatcaag gatcgggtta acctcaacga attcggctga ggtaatgatg 3721321 cctgcgtcat acagcatttc catagccaaa tggctctccc ggtagctgat gccgccgacg 3721381 acaggggttc cgacacccgg tgcgtcgttc ggatcaagtc cgtccagatc aaggctcaga 3721441 tggacgccat cacatgctga taaataatca agggtttctt caatgacctt tgtcatgcca 3721501 agacgatcga tttcgtgcat tgtgtacacc ttcatgccgc tttccttaat gtacttgcgc 3721561 tccccttcat caagtgaccg ggcgccaatg atgacgacgt tttccggttt gattttaggc 3721621 gcgtagcctt caaggttaac cagtgactcg tggccaatgc ctaggctgac cgcgagcggc 3721681 atgccgtgaa tattgcccga tggtgaagtt tcaagtgtat tcaaatcgcc gtgcgcgtca 3721741 taccagatga cgccgagatt atcgtaatgc ttcgctgtgc ctgcaagcgt gccgatcgca 3721801 atactgtggt caccgcccag gacaagcggg aattttttct cttcaatgac tttgttgacc 3721861 ttttgcgcga gtttttcatt tcccgccaaa acggaattca ggtttttcag ttcctcgtca 3721921 tttttgattt tttcgcgatt gatcggaatg tcaccgagat cttcaaccgt ataccccatg 3721981 tctgacagcc tctcgatcag atgagcgtac cggatggcac tcgggcccat atccactccg 3722041 cgtcgtgctt gtcctaaatc cattggcatt ccaataaccg aaatcgtttt atccatctgt 3722101 gattccacct caacatttaa gataatgtcc tatgcgggtt ataacaaaga tgacttgcgg 3722161 acaacgtttt taaagctcta gctgacgatt tgcctgctgg cgttttttaa tgacgacatg 3722221 ataaatgatg tagcaaatga tcataaacgg tacgccgcaa tacagcgcga tacgctgctc 3722281 cggatcaaat gcaagactga tgagcacgac cgtatttaac gttaggccga tcagcggaag 3722341 caccgggtac agcggtgttt taaatttcaa atcttctatc ttcccgccct cacggatata 3722401 tttgcgtctg aacatgattt gggaaagcga gatcgtaatc cagccgacct gcgcgctcat 3722461 gcccgccaaa gataacagta ccatatatac ggtttcagcc tgcgcaaact ttgtcagaag 3722521 tgataggcag gccacagcca tcgttacgat taacgagtac atcggtacac cgcgctgatt 3722581 tgttttgcca agcgctttga aggcttgtcc ttcattcgcc atcgcgtaca gaatacgtgt 3722641 tgatgcgtat aaacctgagt tcgcaacaga taacagtgcg attaaaataa caaagttcat 3722701 gatatcagct gcatatggga ttccgatttg ctcaaatacg gcaacaaatg gactttccac 3722761 gacacccgcc tgtttccacg gaatcatgcc ggcaatgaca atgattgaaa gcacaaagaa 3722821 cacaagcgtt ctccatactg tctgtttgat ggaccgcgga atcgtttttt cagggtcttc 3722881 actttctccg gctgcaaccc cgatcagctc agtcccctga aacgcaaagt tcacagtaat 3722941 catcgtaatc agcattgcct ttatgccgtt cggaaataac ccgtcttcat aaaaatgtgt 3723001 caaaaacggc gcctgctctc cgcccttcag atcaatcagg ccaaacatgg cagctccgcc 3723061 gagaataata aataaaagga taatcaaaat tttaatgcct gagaaccaga attcagattc 3723121 cgcaaaggct tttgtggtga tcgcatttaa aataaacatc agtgccgcaa agaccagaca 3723181 ccagatccac acgtctatat gcggaaacca gcgttgcatc agctgccccg ctgataaaaa 3723241 ttcaatggcg catgtaaccg cccagccgag ccagtacagc cagccgaacg caaacccgaa 3723301 ggccgggctg ataaatttcg tggcataggt ctggaaggac cccgacacag gaaaggcgac 3723361 tgccagctct cctaagcaga gcatggtcaa aaacatgata aagccgccca ctaaatagga 3723421 cagaaccgcg ccgagcggtc ccgcttggtt aatggtaaac ccggttccaa ggaagaaacc 3723481 ggttccgatc actccgccca atgaaatcat gaacaaatgg cgtgatttca ttgtccgctg 3723541 gagctgattt ccgttatctt ggtttgtatt cacattctgc accccttcag caacttgtat 3723601 tggatctaag ctggaacatc tgcatggtgc tatcccagtt tgctgtccaa agagtctcta 3723661 tctatttaat ataaaattca cttcttctca taaagataca ttatactaaa atactgtagc 3723721 tgagcaaata gggagtgctg atttttctgt tgtaaattta tacaaacgaa gtgaatatcc 3723781 cgccatggtg cggatttatg cgtttcgcag cacgtgctta attttctcta tcgcccaatc 3723841 caagtcctct ttggaaatga ttaatggcgg tgcaaaacga atgactgtat catgcgtttc 3723901 cttgcataaa agtccctctt ccttcaaacg ctcacaatac ggacgtgccg cttcagtcaa 3723961 ttccacaccg ataaacagcc ctctgccgcg gacttcttta atgacagggc tgtcaatact 3724021 ctcaagctcg cttttaaagt attcaccaag ttcaagagaa cgatccgcca gcttttcatc 3724081 ctccagcact tctaatgaag cgatagacac tgcacatgca agcgggtttc caccaaatgt 3724141 tgagccgtgt gagccagggt taaacacgcc taggatctcg cggtccgccg caatgcaaga 3724201 gatcgggaac acaccgccgc caagcgcttt gcccaagata tacatatccg gaacaatgcc 3724261 gtcccagtca caggcaaacg tcttgcctgt acgtccgaga cccgtctgaa tttcatccgc 3724321 aataaacaag acattctctt ccttacaaat cgccgccgct tcctgtaaaa atccttcagg 3724381 cggaatcaca atgcccgctt cgccttgaat cggttcaaac aagaatgccg ctgtattcgg 3724441 cgtaatggcc tgtcgaagcg cttccacatc gccgtaagga atgagtttga ttcctggaag 3724501 catcgggccg aatcctcgtt tatattcctc ttcagaagaa agagataccg ccagcatcgt 3724561 gcggccgtgg aagttcccga cacatgcgat aatttccgct tgattgtcag ctacgccctt 3724621 cacttcatac gcccagcgtc tcgccgcttt caccgcggat tcaaccgctt cggctcctgt 3724681 attcatcggc agaatcatct ctttgcctgt cagtttagct gttttttcgt aaaacggccc 3724741 aagctgatcg ttatgaaacg cgcgtgacgt gagggtgatt ttatcagcct gatcctttaa 3724801 tgcctgaatg attttcgggt gtctgtgccc ctggtttacc gcagagtaag cactcagcat 3724861 atccatatat tcattgcctt ccgggtcctt tacccaagca cccagcgctt cagaaataac 3724921 aatcgggagc gggtgataat tgttggctcc gtaatgagac gtctgatcaa taatttcttt 3724981 ggatttagat aaagctgtca tatttgaatt cccccttgtt ttctgtttca acatgttatc 3725041 ctgctttccc tttatataaa tgcaagttct gtgccaaatc aagaattcgt gtgttttcta 3725101 caattttcga ggacaaggtg caaaaacatt ctgatatttc gagcgaaaat ttcagcaagt 3725161 gcaaaattct tttgcatatc ctctccgttt ttttataaaa tagaagcaat attaagaaaa 3725221 taattgaggg aggttcatac agtggtcaaa gacagcgaat tcctcacatt ggtttttcag 3725281 agtattttag atgaaatcga tgttggcctg cacgtggtag acgagcatgg aaacacaatc 3725341 gtttataaca ataaaatgat gcagattgaa gatatggaga agcatgacgt cttgaataaa 3725401 aacctgatgg atgtgtttat gttttcaaag cagcaggaca gcacactggt acaggctctt 3725461 caggaaggca agacgattaa aaacgtcaaa cagagctatt tcaataataa aggccaggaa 3725521 attacgacga tcaatcatac atatcccatc gtccaagacg gcaaaatcag gggcgccgtt 3725581 gaaattgcca aggatgtgac aaagctggaa cggctgatca gggagaatat gaacaaaaaa 3725641 ggcagcacaa cctatacgtt tgacagtatt ctcggcacca gtccggccat tcaagacgtc 3725701 atcgaaaacg ccaagcgggc aacccgtacg tcatcatctg tccttctagc aggcgaaacc 3725761 ggcacgggaa aagaactgtt cgcgcaaagt atccataatg gaagcgatcg ttctggcggc 3725821 ccgtttattt cgcaaaactg cgcggcactg ccagacagcc ttgtggaaag cattttgttt 3725881 gggacgaaaa aaggcgcgtt taccggcgct gtcgaccagc ccggcctgtt tgaacaagcc 3725941 cacggcggca cactgctgtt agatgaaatc aactcgctga atctcagcct tcaggcgaag 3726001 ctgctgcgcg cccttcaaga acggaaaatc aggcgcatcg gttcaacaaa ggatacaccg 3726061 attgacgtac gtattattgc cacgatgaat gaagacccaa ttgatgcaat tgcaggcgaa 3726121 cgaatgcgga aggacttgta ttacaggctg agtgtcgtca cactgatcat cccgccgctt 3726181 cgggaacgaa aagaagacat tttgcttctc gcgtcggagt tcatccagaa aaacaaccat 3726241 ctgttccaaa tgaatgttga acacatcagc gatgacgtga agcaattttt cctttcttat 3726301 gactggccgg gaaatattcg cgagcttgag catatgatcg aaggcgcaat gaatttcatg 3726361 acggacgagc aaacgattac ggcttcccat ctgccctatc aataccgcat gaaaatcaag 3726421 ccggctgaca tcccagagcc ggaaacacca agacaccagc cagccgcgga cttaaaagaa 3726481 aaaatggaaa gcttcgaaaa atatgtgata gagaacgtgt taagaaaaca cggccataac 3726541 atctcgaaag ctgctcagga gcttggcatc agcagacaaa gcctccaata tcggctgaag 3726601 aaattttctc actcgtctaa cgaataatcc ggagcaggaa gcctgatcag aaaaacagtg 3726661 cctctgccga tttcactttt cacttcaatc gtcccattgt gattgtcgat aatcgatttc 3726721 gttatggcaa ggcctaatcc cgaacctcca tatttccggg agcgggatgg gtctgccttg 3726781 taaaaccggt caaacactaa aaaacgtcac ttcttatgca ttgaagaaag aaaatggcac 3726841 ctatgtgtat cacagccagc aaccacacgg tacaaaccat taaagtccat gcaaataacg 3726901 gaagtatttg cagctaactg ccatttgctg tttcacgtgt aacatccatc ttgtattttt 3726961 cttcatattc gatatatcct ttttcaactg aacgggcgtg acccctgttc agtttttttt 3727021 gcatatcaaa acagcctggc aacgatgcca gactgctttt attaactgcc taattggtct 3727081 gcggaggaca gcttgatatc aacagatttt tcttttccgc cgcgataaaa cttcaccttc 3727141 acccggtcac cgactttttt ctgataaagc cgttttcgca ggtcaacaat atcatttact 3727201 ttgtatccgt caaattccgt gatgacatcc agttccttca gccccgcttt tccggcaggt 3727261 gaaaaggcgt ctacacccat cacaaccgct ccattggtga cgttcttagg aagctttaat 3727321 gtttcatccc aatgatagct tgcgatgtca cttagcgatt tcatctcaat gccaaggaac 3727381 gggcgtttga cctttccgta tctctctaaa tcctctatca cagggatcac gagcttagac 3727441 ggaatggaca ggccaatccc ttcaaccgct gactcggcaa ttttcattga attgatgcca 3727501 atgaccttcc catccatatt taacaaagcg ccgccgctgt tcccagggtt aatggccgca 3727561 tctgtttgca ggacttcagc gttccagtca ggctgtccat caccgtttga atctactggg 3727621 atcgccctct ccgtacccga gatgacgcct tgtgtgacag agcctgcaaa ctcaaggcct 3727681 aacgggttcc cgatcgcaat aaccggctcc ccagacttca ctttatctga atttccgaaa 3727741 tcagcgactg ctttaatctt atcgcttttc acccgtaaaa cggcaaggtc catcagctgg 3727801 tcgctgccga caagatcagc tgatacacgt gagccgtctt tcaagctgat ttcaatttgg 3727861 gaagcgcctt cgatgacatg atggttggtc acgacataag cggaatggtc atttttctta 3727921 tagatgacgc cagagccgct cccagcctcg ccgctctctc cccaaatatc tgatttttgg 3727981 atgttcacaa caccgacaac ggcgggcgac atattgctga caatcttggt gacggcattg 3728041 ttgacactga cattcaccgt cctgattgat tcccggccat tgttgttttg ctgctgatct 3728101 aaggcgcctg tatccagccc ttcatttgaa aggtacggca tgataaacgc cattaatacg 3728161 gcaccgacaa tcacgccaat cagactcgaa agaaaatatc cttttttgct tctctttggc 3728221 tgttcaggag tagtatgttc ttcctcacgt tcgtaatcca ccatattcca tcctttccaa 3728281 gaacgttaat atggttatat tgtgggttag aaactcctag aatagtcatg atttacatag 3728341 aaaaattata cagcgcaaag cggagtggcc ttcttcggat cggtgtcgta taagtcaaat 3728401 gtctcacccg tcacaaatcc tttagaagcc aatgtctgct gcacagacat tcttgccagc 3728461 tccttcatgt tgttgtcctg gctcaaatgc gccaggtaaa tacgagacgt ctcatcgcca 3728521 atgacatccg tcatcgccaa ggcagcatct tcatttgaca cgtgcccgac gtcacttaaa 3728581 atccgccgct taatgctcca tgggtatctt cccatttgca gcataccgac atcgtgattg 3728641 ctttcaaaca caaatacatt cgctgaacgg ataatgcctt tcatccggtc gctgacatat 3728701 cccgtatctg tcattaacgc gagctttcgg ccgctataat ggaatacata aaacatcggt 3728761 tccgccgcat cgtgggaaac gccaaacgat tcaacatcaa gtccgccgaa cgacttcacc 3728821 gtctccattg gaaatacaaa cttttgatcg gtgtcaattt tgccgatttg attctccatc 3728881 gctttccaag tcttctcatt cgcatagatc ggaagcttgt actttctggc gacgacacca 3728941 aggcccttaa tatggtcact atgctcatgc gtcacaaaaa tgccgtctac atcatccagc 3729001 ttacgcccga tctgcgccat cagcccatcc atggcttttc cgctcaaacc ggcgtccact 3729061 aaaaatgcgt gatcctctgt ttcgaggtaa aacgcatttc ccgtactccc gctcgcaagt 3729121 acgctaaatt gcaagctcat gtttgtctca ctccattatt ttcattgatc tgtatctaaa 3729181 atcgtactct ccaaagcatt cacagtaaaa tactcttgta ctgtcttttt ctcaccgttc 3729241 acttttttct cgtactcgac cgtaattctc cataccggcg ccagcacctg cgtacttgtc 3729301 agcggatatt gtgctacata gccgaattta cagctcttca cagtgctgta ttcttttaat 3729361 tgattttgat agtacaatag ctcaaccgca tccatttcag taattaagct ttctttctgg 3729421 atttgcttga aggtctcaag cgtagtctgg tcgtatgaca caacctcgtt tttaccgttt 3729481 aagtgcagca ccacttgccc gatcatatta gagggattgt cggtcttttg gtaaatataa 3729541 tgaccttcgt acgtttggaa gaaaataatt tctttcttcg atttatcaac cttccaaagc 3729601 ttatattttt cgccatcttg aattttcgaa gaaacaagtg cctgagcatc gtcctcgata 3729661 tccttctttg atagtgcgat tggatttgca aacttcattt tcaggctcgt tactttatga 3729721 tcatcactag gcatgtccat caaaggcttt tgatccttca gcgcctcaat ttcctccttg 3729781 gagaaagact tttgatttgc cgtgatccga tagccttctg ttgcttcctt attcaagcct 3729841 tcatacgtga tatgatcggc cttcatgtca tgctcgacat catttttaat gacttcatat 3729901 tctttgccgg tagcctgcca tttttgaaaa aactgatagc ctaagaaaat atctaaaatg 3729961 aggaaggcaa cgatgaagat tgattttgtc ttattccact ccactgttag ccccctcctt 3730021 cctcaataaa tcctttgtaa tcggcacaat ttttccattt actttcatcg cccaaaccgg 3730081 ttccagttca acgagaggat catcgttggt tgatgttgat accaattgat aagcaaggaa 3730141 gatctgatca attttgtccg tatcataagc ggtttgtttc gaaagcagca tcttcacttc 3730201 gctgccgccc atgagctctg tttcacttgt tttaatcgga ttcgttccga gactgtaatt 3730261 cggccgctta tagctgagaa tatcatcatt cgcccattgc accgtaatcg ccgatgtcgc 3730321 cccgaaaggt ttggcggtgc tgttaatgac cgggatctga tccataaaaa tatagaagct 3730381 caactgctgg ctgtcattga tattgaaaaa ttgatagtga tccgtccagc ttccggtatc 3730441 ctcaaggtat ttttggctct ttttgattaa ttcacctgtt tgataggatg tgctctgcac 3730501 caaattgcgc tgctgaaatt gcacctgtct ctggcttaga ttcacatcta accggctgat 3730561 cccatctgtc agcacatttc tgttggtgta attcgaatct tctcttacaa tgctcggatc 3730621 actaaacaaa gcctgcttaa aggtatttgt tttaatcgat tctgtgacaa attctttttt 3730681 gtccatcgta agcggtttgt tcggcagcaa gaactctttc tttgagccaa tggagaacaa 3730741 actgaacgcc ggcatatttg attgcctgtt tttcaagtcg ttcataatgt tccggtagtt 3730801 tgctgattca accgtcactt caagaatgag ctgcttgctg tatgacacca aatagatttt 3730861 cttgttcgct tttgtttcat tgaacgggat cagaatatgg tcaaacgaac tgtattcaaa 3730921 cgactgatta gaccatttaa acagcgtttg gaaaatatca atcgggatcg tatcgctgaa 3730981 ttgcaagtca agcttggctt cagaaccgcc tattccataa aaccagcttt tgaatccagc 3731041 cttgtcatac tgatccgaaa tatctttaat tcctttcaca tcccaatgcg gcaagtcaga 3731101 ccaaatttct tcatagaggg cattgtcatc cactttgtaa tgagcgccgt catcatggat 3731161 aaacatgtcc cttggcctta ccgtttcaga cagcttttgg gtggtttttt cgattttatg 3731221 tttcacacga acagtagact ctgttgagga tgagccttca gaaaagtttg gctggaacgt 3731281 ccatatcccc catgtaaaaa caagactgat gacgacgagt accgtaagta atatcgtttt 3731341 tatattttca cgcttcatcc caatcatcct cttgttcctc tttatatgga agagtaaatg 3731401 taatcgtcgt gccttttcct tctatgctgt ccgcccaaat atctccaccg tgcgcctgta 3731461 ccatttcctt ggcaatcgcc aatcccagac cggtgccgcc aagctttctc gttctcgctt 3731521 tatccaccct gtagaagcgg tcaaagactt tttcgacatc ttttttcgga atgccgatcc 3731581 cttcatcctt cacgctgata tagagaagtt cttcctcttc attgacatca atcgagaacg 3731641 tgacatgtcc gccttccggt gaatatttta aagcgttaga aataatatta tcgagcacct 3731701 gcgttatttt atcctggtca atctcgacat acagatctct gtccggcaga ttgcggataa 3731761 actccacatg ctgctctttt gtcatttcaa aacggtcaat aataagtgac ataaaccgga 3731821 caatctgaat ccattcccgg ttaaattgat aatctttact gtcaaatttc gacagctgaa 3731881 gcagatcatt gacaagccgg atcatacgct ctgtttcatt ttgcgtcacc attaagaagc 3731941 gcggagcaat gtctttattt tcccacgcgc cttcagctaa cgcttctaaa tagctgcgca 3732001 ttgtcgtaag cggcgtccgc agctcatgtg atacattcgc aacgaattct ctgcgttcct 3732061 gatccatttt ctcttgttcg gttacatcgt aaatgacagc gattaaacca tcaattttgc 3732121 cgtgttccct ttgaatcaca gagaaattca cgcgaagcac cgttaattca tcatcgcgct 3732181 caatttcaag cagcatagaa tcctgctgtt ccactaaatc ttcaaaagta taattctctt 3732241 gaagccccag caaactcgta atcggcattt ctaaggctgt ttcacgtgaa acgttcaaca 3732301 gttccagcgc cgggctgttt aagagaataa tcgctccgtt tcggtttgtg gcgataacgc 3732361 cgtctgtcat ataagcaatg acagaggcta gctttctgcg ttctccttca gtcatcgcct 3732421 gggcatcttc aagctctctc gttaagtggt taaacgttgt ggccagctgc ccaatttcat 3732481 catgtccata ctttttaacc ttcctcgaga aattcccttt cgcaagctcc atcgcctgct 3732541 ttcgcatatc tgaaagcggg tgggtaatgg ttcttgccag aaaaataccg agaagagccg 3732601 tcaaaacaag tgccaaacct gtgccggacg ccagtatcgt gttgatcgtc ttcatttgat 3732661 taaagacatc ttccatactc gcgacaacgt agatcgcgcc cacaacctct tggttttcag 3732721 tcatgacggg cttcgcggaa ataagaactc tgattttgct tttcgggtca taatattttc 3732781 ttaaatacga ctgtttggta gaaaagattc ttttgaaaat cagatcggtc gtttgtttcc 3732841 cagccacttc ctcaccgtac ggctttgaag aaccgaccac ttcatagctt ttatctacaa 3732901 agctaatttc ccgaacctca tcacttttcg tgaagtcatt caaaatacgg ctgacgtcat 3732961 cctttatgac ggtactgtcg ttatcgctct tatattcttg ttcgatataa taagaaaggt 3733021 tgtcgattcg ctgattcagc gattgttcat aagagctgat cagcgacttc tctacctgat 3733081 tgacaaaata cacaccaatg atttgcatgg caatgataat caaaagcaca taaatcaagg 3733141 taatcttaaa ttggatcgac cgaaaaaaac caaccttatt catatgggca ttagtcctgt 3733201 tctgggtttc tcaagtaata acctacacca cggcgtgtga cgatccaatt tggatggctc 3733261 gggttgtcct cgattttttc acgaagccgg cggactgtta cgtcaaccgt tctgacatcg 3733321 ccgaagtaat catagcccca aacggtttga agcaaatgtt cacgggtcat cacttgtccg 3733381 atatgttttg ctaaataatg aagcaattcg aactcacgat gagtcaattc gattgtttcg 3733441 tctcgttttg atacaacgta cgcgtcaggg aagatgacga gagagccgat atgaatctcg 3733501 ttagaggaag gctcttcctc cgcaggcgct gttgtcagct ggcggcgcag gttcgctttt 3733561 acacgcgcca agagctcgcg tgtgctgaat ggttttgtga catagtcatc agcaccgatt 3733621 tcaagcccga taaccttgtc aatttctgaa tccttagccg tcagcataat gattggcata 3733681 tcgtatttct ttctgacttc gcggcatact tcaacgccgt ctttatttgg gagcataata 3733741 tctaaaagaa ttaaatcagg ctgaagctct tctaccattt caacggcttc gtttccgtcg 3733801 tgggcacagt gcacttcata gccttctttt cttaagttaa attccaatat atctgcaatc 3733861 ggtttttcat catctactac aaggatcttt ttatccatca ttttgatttt cctcctgccg 3733921 aatgacttca tttcatctat ataacattcg tttcatcact tatggcccat gtaaagaatg 3733981 ggtccttgtc tattataacg gtttaaggtc aaaagataaa aaaaataaag gtttagaaaa 3734041 aaaacacatg tttcaccttt atcgccagtt gtttatctat tgtcatgctg gtcaactttt 3734101 tttaaaaaag ataactttat tgaaacctcc cctcaccgga gtgcgtcttt atcaatgacg 3734161 tcttcttctt tgaaccggcc gcagggccgg ttctcccttt ttcttctatt ataacactcc 3734221 tcatgtttgc ctttttccta aaagaaaaaa cgcacctacg attgcagatg cgtttggtaa 3734281 gtggctcggg acggaatcga accgccgaca cacggatttt cagtccgttg ctctaccaac 3734341 tgagctaccg agccaaatgt tttatttttc tctactaagt aaagtaaaat ggcggtccgg 3734401 acgggactcg aacccgcgac ctcctgcgtg acaggcaggc attctaacca actgaactac 3734461 cggaccttac agtaattgcc cggagagctg tcgtgtcagc tctcacagac aaataaggaa 3734521 tttagcaata acgctaaagt aaatcaatga cccgtacggg attcgaaccc gtgttaccgc 3734581 cgtgaaaggg cggtgtctta accgcttgac caacgggcct tcacgaaatg gtgagccatg 3734641 aaggactcga accttcgacc ctctgattaa aagtcagatg ctctaccaac tgagctaatg 3734701 gctcttaaag atgtcggaat ttctatagag caaacgactt aaatctagtt ctcatcttgt 3734761 actctattga agcagtttcc gtaacaacga gatttataat atcacgaaca aatagaagtg 3734821 gcaataactt ttttggtttt ttttcatatt tttttctcag accaacttat atgcggcttt 3734881 caaacaaaaa acaagcccct taaatagggg cttgcagaca tattctattt agttcgcacg 3734941 gtacacactg cgaaggacat ttgtttgtga gcggtctgga ccgacagaga aaatagaaag 3735001 cggaatgcct gtcagctgag acacacgctc aagataatgg cgcgcatttt ccggaagctc 3735061 gctcaagctc ttcgcacctg taatatcctc agtccagccc ggcatttctt catataccgg 3735121 ctcacattca gcaagtgcct taagacttgc tgggaattct tcaatgattt cgcctttgta 3735181 gcggtacgcc acacagattt tcaacgtttc aattcctgct aggacgtcaa ttgagttcag 3735241 agaaagatct gtaattccgc tcacacggcg ggcgtggcgg acaacaacgc tgtcaaacca 3735301 gccgacacgg cgcgggcggc ctgttgttgt tccatattcg cgtccgactt cacggatttg 3735361 atcgccgatt tcatctttca gctcagtcgg aaaaggaccg tcgccgacac gagtcgtata 3735421 tgcttttgat acaccgacaa cgtgcttgat tttggtcggg ccgacaccag aaccgatcgt 3735481 gacaccgccg gcaaccgggt tagatgacgt aacaaacggg tatgttcctt ggtcgatatc 3735541 gagcataacc ccttgtgcgc cttcaaataa tacacggcgc ccttcatcaa gagcatcgtt 3735601 taagacaaca gatgtatcgc aaacatactt tttaatctgc tgtccgtact cataatattc 3735661 gtctaagata tcctcaagtt taaacccttc tgtctcgtac attttctcga gaagacggtt 3735721 tttttcttca agattgcgct caagcttttc cgcaaacgcg tcacggtcta acagatccgc 3735781 gatgcgaatt ccgatgcggg ctgctttatc catgtaagca gggccgattc cttttttcgt 3735841 tgtgccgatc ttgttagccc ctttacgctc ttcttccact tcatccaatt tcaaatgata 3735901 cggcagaatg acgtgagctc tgttgctgat tctcaggtta tctgtactca cgttgcgctc 3735961 atgaagatac gcaagctctg tgactaatgc tttcggatct acaaccattc cgtttccgat 3736021 tacacacgtt ttatccttat agaaaattcc agacgggatt aagtgaagct tatatgtgat 3736081 tccgtcaaac ttgattgtat gccctgcgtt atttccgcct tgataacggg cgatcacttc 3736141 tgcattttct gataggaaat ctgtaatttt accttttcct tcatcgcccc attgcgtacc 3736201 tactacaact actgaagaca tgtccgtgca cctccgttaa cctttcaaaa cgattctatt 3736261 caaacaaatc aagtttatca gtgaagaaac agaaagtcaa ttgtaaatcc gaacattaat 3736321 ttattgtaaa tctatattcg ttcgcttcca ttcgttttat aagcgttttc tcactgcttt 3736381 gtcataaaaa gcttgcgaaa ctttcatcct ttagcataag aaagaatcac ttgcctgata 3736441 tcccttttga attcataaaa acgatccgcc agccgtccgg gtcctctatc gtcacgcccc 3736501 cattgctcca gtacgggttc tctgattcga cctcttgata gcccatgtgc tttagctttg 3736561 aagtgatcgc tgccagttca actgcattcg gcacataaaa aacaagaagg ctgtcgggat 3736621 ggggaacggg ggcagtgctt cccccttcat actgggtgaa ttccaaatga taatcggcat 3736681 gaggaaggcc gaacatgaca ccgtcatacc cgttatgctg tgaaaattct cctattcgtt 3736741 tcaaacacag tccctcttcg taaaaacgaa taatctcatc aagctggccc gtaggacgcg 3736801 caattcggat ttgtgctgct tgaaaagacg aaaaacgttt tcccatattg ttaccatctc 3736861 ctttttgcac cattttatta aaacgctttc aatttttcat ccgctgagcg aacgtcattt 3736921 cttccatctt tcgaatgaaa aaaaccccaa gagcagctct tggggcttat gcgccgggcg 3736981 gaacgcctgc gtcatcaaaa cgccgttcca ggttgacgaa tttgttgtat tcttttacga 3737041 acgcaagaga cacggttcct accgggccgt tacgctgttt ggcgataata atttcgataa 3737101 tatttttatt ctcggtttct ttgtcatagt agtcatcacg ataaaggaac gcgacaatat 3737161 ccgcgtcctg ctcgatactt cctgattccc ggatatcaga catcatcgga cgtttatcct 3737221 gacgctgctc aacacccctg gaaagctgag aaagcgcgat aacagggact tgcagctccc 3737281 tcgcaatcga cttcagttca cgggaaattt cagatacttc ctgctgacgg ttgtcctttg 3737341 aacgaccgct tccctgaatc aattgcaggt aatcgatcaa aatcatgccc agcccgcttt 3737401 cctgcttcaa gcggcggcac ttggcacgga tttcactcac tcgaataccc ggtgtatcat 3737461 cgatgtaaat cccgctgttc gataggcttc ccattgccat cgtcagcttg ccccaatcct 3737521 cttcggtcag gttacctgta cggagattct gggcattgat atttccctcg gcacagagca 3737581 tacgcataac gagctgctcg gcacccatct caagactgaa aatcgctacg ctctcatcgg 3737641 tcttcgtcgc cacgttttgt gcgatgttca gggcaaaggc tgttttccct actgaaggac 3737701 gggcagccac aatgatcaag tcgttgcgct ggaaacccgc agtcatccgg tcaagctccg 3737761 taaaccctgt tggaattccc gtgatatcac cttttcgatt gtgaagctgt tcgatattat 3737821 cataggtctg gacaaggacg tccttaatat tttggaaggc actcgtgttt ttgcgctgtg 3737881 ccacttccat aatcgttttt tccgcttcac tgagtaaatc ctcgacctca tcctcacggg 3737941 tatacccgtc ttgagcaatc gttgtcgcag ttctgattaa tcggcgaaga atcgattttt 3738001 cctcaacgat tttcgcgtaa tattctatgt tagccgctgt cggcaccgag tttgcgatat 3738061 ctgtcaaata tgaaataccg cctacttctt ccagcaggtc tgtgttcgca agctctgatg 3738121 taactgtcac cagatcaacc ggttcacctc ggtcaccgag caccagcatc gcattataga 3738181 ttttttggtg ggacattcta tagaaatcat ctggaatcaa tacttctgaa gccagtgtta 3738241 aagcagacgg ctgtaaaaaa atagcgccta acacggcttg ttcggcttct atattttgcg 3738301 gaggaagccg gtcattcaga aggtctgtca tgctaagcac cgtcctctca ttaaaaaatc 3738361 tccaacctcc attctaccat ttctacagaa aaaaaataga aaaattgtct gtttcctgtt 3738421 tttttcagtt agcagattgg atcgtttcgg acagtaacaa ggcgggaaaa atgcaataaa 3738481 acataaggga ggaatgaaag atgataaaga aatatgcgat tacacctaat gttgatgcgg 3738541 acggctggtt tattgaggtg gagaatgtag cgccgacagc tttgtatacg tctaaagacg 3738601 ccgctattga aaaggccaaa caggtggcta aggaaaacag tccgtctaag cttgtaattt 3738661 atgaccagtt taaaaatgtg gaagaagaac actcatttta atgaatgaaa gccttcgctg 3738721 cagcgagggt tttttagcgg ttatcggttt atttcatcca ttggatgcct atgtgcatca 3738781 tcaaatctgc cgctttttga tacagatccc actccccgat cgaagcaaat ttccccatca 3738841 gctcctgaag ctttaacctc attgctatat attcttcgaa agtgacagct ttttcagtgt 3738901 ctatttggtg ttccttcagc atttgtttta ataaggataa cggtgcgtgc ataagaaccc 3738961 tccttacctc ttttataacg gtcattttcc gattgctcta ttcctttgtg acatcttctt 3739021 acatttcaca tctgattctt gtacaatgga cagaagagag gagggatctt ttgtgagacc 3739081 tttgcaaatt tctgccgaaa ctgcacaaaa gcttgcagag tccttgaatc tgccgcttga 3739141 acagatcatg catatgcctc agcatattct gcttgccaaa atggctgaac tgcaaaaaga 3739201 ggacaaatca tagccttcat tcacatactt gcttacctgt ttcgggataa tatcatgtat 3739261 atgttagaaa agaggagtaa ctgctttgcc acatccacat aataaaaaaa tccaatcatt 3739321 ttggctgatc accggcatta tctttatcgc ctttaactta cggcccgcga tcacttcagt 3739381 cggtccggtc atcagctcta tccgggcaga gctgcacatg tccaatgggg cagccggttt 3739441 tttgaccgca ctgccgctgc tttcgtttgc agttctttct ccgcttgcac ctaagcttgg 3739501 acagcgcctc ggtaatgagc gaactttatg gctaggtctc gtgatactgc tgatcggtgt 3739561 tctgactcgt tctaccggct atactgccgc tttgtttttc ggaacagcac ttatcggcgt 3739621 cgggattgcg attggtaacg tacttttgcc aagcttaatc aaacataaat accctgaaaa 3739681 gccagggatc atgatcagcc tgtatacgac atcaatgaat atattcgcag ctttagcatc 3739741 gggtgtcagc gttcctttag cgacccagat gaatggcgga tggaaacaag cctttctctt 3739801 atggggcggg ctggctttac ttgcattgct aatctggata cctcagctgc gccatcgaga 3739861 tacggcaaac cagacaatga agctgcaatc cagttccatt tgggcttcca aaatggcatg 3739921 gtatgtcacc atctttatgg gcctgcaatc gtttttattt tacagcagca tcgcttggtt 3739981 tcctgaaatt ctccgttcac acgggattga tacggcaaca gccggatgga tggtatcact 3740041 catgcaattt gcgagtctgc cttccacttt tctgacgcca gttttagctg accgtgtgaa 3740101 acagcagcgc ggtatcgttg cggcgctggc ctcagtttat ctgatcggcc tttgcggatt 3740161 attagcgggc ggaagccata cattgcttgc catctggatg atcattatcg gtatcggaca 3740221 aggctccagc attagtctgg cccttacttt gattggtctc cgcagtgaaa atgcccaaca 3740281 ggccgctgcg ctgtcaggca tgtctcagtc attcggctac ctgctggcag cagtcgggcc 3740341 aatctttgtc ggctatctct ttgaccagac gcattcttgg acgatgccga ttgtgcttct 3740401 cattgctgcc ctgatcgtaa tgggagcagc cggacaggga gccggacgag atcgatacat 3740461 tttccagtca gaaaaacaaa gaaattcagc ataaagcggg gaagatatct ccgctttttt 3740521 ctttgaatat ttatggttta ttcataagtt tttcatattt gttttttaca atgagacacc 3740581 ataaagaggt gaaaaacgat gaaaaccaaa cgattcgacg cagcccttat tcttattttg 3740641 ctagcagcag cttttttgaa tacgtatcac atttggcagg atgatacagc aaaccagtac 3740701 tatttggcgg ctgtaaaaag catgacgcaa agcttccata acttttttta tgcgtcattt 3740761 gacccttctg gatttgtgac agtagataag cctcctgtcg tgttatggat tcaaacgatt 3740821 ttcgcactga ttttcggtgt tcacacgtgg agtgtcatca ttccccaggc tcttgccgga 3740881 gttggatctg tcttccttct ctacagaatg gttaagccga cttttggagt tggagcggcc 3740941 cgcattgccg cacttgtcat ggcactgacc cctatcgcag tagctgtcag ccggacaaac 3741001 aatatcgaca gcatgcttgt ttttacctta ttgctcggtt caacttgtct gcttagggca 3741061 gtaaaacaag gcaagctggt ttggctgctg acggcatttg ccctgattgg gctcgccttt 3741121 aatatgaaga tgatgcaagc gtttatggta ttgcctgcat ttgtgttatt ctacctgatt 3741181 gcatctcggg tttctctgaa gaaaaaaatc gggtccctgc ttctgtctct tgtccttctg 3741241 acaggccttt cactctcatg ggcgattgca gtggattcag cctcttcctc aagccggcct 3741301 tatgtaggaa gcagccagac taactcagtg ctagaactgg cctttggcta caacggcaca 3741361 gagcgtctgt ttgggcaaac tacgggcctt gcaaagggtg atatgaatgc tgctggcgga 3741421 gggaacatgc agaatcaaga caacatgcaa gcgccaaatg gcaacggttc atctttttct 3741481 cagaacggta atcaatcatt cggaaaccat tcacaggcgc ctcagccgcc taacggacaa 3741541 accggcgctc tcaatggagg cggaggcaca cctcccacag gtggcaacgg acctggaaat 3741601 ggagggcctg gcggcggagg cggaaaaagc gtgaatatgt tcggcaccgg tgatcctgga 3741661 ccgcttcgtc tcttccaatc agcactttcc ggccaaatca gctggatgct tccattctca 3741721 ttgatcggat tactgggcgc aatcatcagc tggtaccgtg atcgccgcgg acatgctgct 3741781 aaaatgaaag aaacgctatt ctgggcggct tggcttgttc ccgtggctgg tttcttcagc 3741841 atcgcaggat tcttccacca gtattatttg attatgctgg caccgccgat tgccgccctt 3741901 tctggtatcg gatggtatac gatgcaccgc ttatacaaaa ataataaaga ctggtccagc 3741961 tatcttctgc cggcagccgt cttgatcaca gccgtgtttc aggtgtatat tctgagcgct 3742021 tatacaagcc aaatcggcag tgtatggatg tatgtcctgg ggctcttagg actgggcatc 3742081 acccttgcac ttctgatgct taaacgcagc catccgttca gtaagctgct gaccatcatc 3742141 agcttgtgcg ttctgcttct cacaccagtt tactggtcag caacgccgct tctatacggt 3742201 ggcaacagcg tccttcctga atccggcccg cagctcaaag gctcagcaaa cggcgggaac 3742261 atgttctctt cagaggtcga cagcgggctc ctgtcctatc tgagaaaaca caataccggc 3742321 gaagagtatt tatttgctac tttgacaacc gtaacagctg cgccatacat catttacgaa 3742381 aatgaatctg ttatggcaat gggcgggttt aacggcacgg atcccattct gactgtgtcg 3742441 gaactgaaaa aactgatcaa agaaggcaaa gtgaaatact tccttctgtc agaaaacaac 3742501 tcaggcaaca gcgaacttgt ttcctggatt aagaaaaacg gaaaagaaat aacatctgac 3742561 gagtacagcg gttcctccag cagcacaaac agcgtgcagg gaatgcgaag aggacctggc 3742621 ggagaaagcc agcaaactct ttatctcgtg gaataaaaaa agaggcttgg atgaatccaa 3742681 gcctcttttc tattaagctt cttcttttac atgtaccttt aacacagcct gcacttcagg 3742741 atgcagcttc acaggcacgt ttgtatatcc taatgcacga atgccgtccg gcagttcaag 3742801 cttccgctta tctactttaa tgttatggtc tttttggagc tgttcagtga tttgcttgct 3742861 tgtcactgaa ccaaataaac ggccgccctc acctgatttt gcgctaagct caacagtcag 3742921 tttttctaat gtctctttca agctcttagc ctgctcaagc tcagcaatgg cttctttttt 3742981 ctctttctgc ttttgtccgt ttaacgcgct gatgtttgac gcgttcgctt caaccgcgag 3743041 gcctttttta attagaaagt tatgcgcata accgtctgct acgtttttga cttcgccttt 3743101 ttttcctttt ccttttacat cttgtaagaa aataaccttc atctctgtac gcctccctca 3743161 aaatactcat ctatggcgtg cttcagccgt tccagcgctt cagaaactga aatgccggac 3743221 aactgagtcg ccgcatttgt taaatgccct ccgccttcca gggcctccat gatgatctga 3743281 acatttacct cgccaagcga ccgagcactg atacaaaccg tttgttcatc ccgtctcgcc 3743341 accgcaaatg aagcctcaac ctcactcatc gatagcagcg aatcggcagc ctgcgcaatc 3743401 agcacttgat cgaagtattc ctcttcattt tcaggaagag aagcaatcgc aatgttatct 3743461 ttatagagga ccgtatgctg gatcagcttc gcccgtttaa tataggaatc aacggtttct 3743521 ttcagaaact tctgcaccag caccgtgtcg gcgccttttg cccttaaata agaagccgca 3743581 tcgaaagtcc gcgagcccgt gcggagagaa aagctctttg tatccactat tataccagct 3743641 aatagggctg ttgcttcaat catattgatt tttaagcgct tcggctgata ttcaagcagc 3743701 tctgtcacca attccgctgt ggaagaagcg tatggttcca tataaacgag cagcggatct 3743761 ctgataaact cctcacctct tcggtgatgg tcgatgacca cgatatgttc aattttattg 3743821 accagccgtt cctccatgac gagtgacggc ttatgtgtat caacgatcac aagcagtgtg 3743881 tcatcattgg aaatctccat tgcttcttca ggcgtaataa atcttgacca cagttcttca 3743941 tattttttga tttccccaat caaacgctgc acacttgatc cgatttggtt tgggtcaatc 3744001 acgataaaac catctttgtt atttgcctga gccaccttta aaatcccgat cgctgcgccg 3744061 atagaatcca tgtcggggaa tttatgcccc atgataatca cattgctgct ttcggtgacg 3744121 atttccttta aggcgtgaga aatcacgcgg gcccgcaccc ttgttcgttt ctccattggg 3744181 tttgttttac cgccgtaaaa cttcaccttg ccgtttggca gcttaatggc tacctggtct 3744241 ccgccgcgtc ccagtgctaa gtccaagctg gattgcgcca aatcgccaag ttctttcagg 3744301 gaagagactg aagccccgac accgacgctt aacgtcagcg ctacaccgtc aaacgaggtt 3744361 ttttcccgca cttcatcaag aatcgaaaac ttcgaatttt cgagttcagt taagatatgt 3744421 tcattaagta cagcaataaa gcgttctgaa gacgtccttt tcaagaagat cccgtactcc 3744481 tgcgcccaag cgttcagcaa agatgtcacc tggctgttca tcgtgcttct cgtctggtca 3744541 tccaatcctt gtgtcacatc atcatagtta tcaaggaaaa tatatgccag gacggttctt 3744601 tcgttttcat atagcttttc aatctggatt tgttctgtta catcaaagaa atataagaga 3744661 cgctcatccc gtttgatgac aaccctaaac ttgcggtcat tcaatgtaac cgtttccgat 3744721 tccacctctt gtttgataag cggcactacc gattcacaag tatcgtaaag tgatctcccc 3744781 actaaagtgc tttcattaaa acaagaggaa agaaacggat ttgcccattc tatataatat 3744841 tggtcattaa aaagcatgat tccaatcggc atttccatca atgcctcttc accgactttt 3744901 ttcaacctgt aggacaacgt agaaatataa gcatcaatct cttgtcgaat aagagaatca 3744961 gcacgcttaa taaaaaacaa aataactgcc agcagcagca cttcgacggt tcctaatatc 3745021 cagttaaaat aaaagctgat gaggattgta ataattgaca gagcaatcaa tgcatagatg 3745081 ggataccgaa acagcggttt ttcataaaag cttggcattt ctatcactcc ccaccatgtg 3745141 agtaaaactc atgttcactt caccttattc cttatatgaa agcccatatc taaaacgcct 3745201 aaaatgcgaa tggccgccat gaagaccgga tgcacaaacc caagtatgac agcaatcaca 3745261 gccgcagcct ttggatattg tttcttatgg caatagaaaa agataaatga taaaccttgg 3745321 atgaaaatca gaaacccgag tataaactcc ccatttaaag cgatagagta cagcatttgg 3745381 cctttttcta aaggcaaaaa tgaaagcatg acaataatca aatacagtac tacaacactt 3745441 tgcggaaact tcaactctct aaaaggcttt agattaggaa tatcggggga gaatcgcctt 3745501 aagagcggct tagcgataag gtaactgagg aaagaaaaaa taactcctac catcacaata 3745561 gctgttggaa aaagatattg aacgataccc aattgttctt ccatcagttt taattgcttc 3745621 tcaaactgcc cagcattgcc cgactgcttc gctacagttt ctacaatatc aagagattgc 3745681 cggtattgtg tcattgcctc atcaatgata ttgataccca aaaactgaat gcttatcaca 3745741 aaatagaaga caatactaag catataaata agagcgcccg aaataatggc gtgcccgggc 3745801 tctttccttt tgaaaaaatg tcccatggca atgccggcgc aagctgacat aaaagctaca 3745861 ataagcccgt taaaggaccc gacaataaaa acaaccggaa gactgacagc gcccatccat 3745921 atccctagct tcaatccatg tctgatcgta tacaagatca ttggcagcgg cagtgcaaat 3745981 aacagaattg ttccaatcac aggaacataa acgaccagaa gcgtaatgat cgcaaacaga 3746041 ctgattaaaa tagcaccttc cattaaagct ctcgtttgtt tcacttagtc acctcgtatc 3746101 atcctgaaca tacgaataga aaagagcagc ataaacgact gctcttttgt tcatcgctgc 3746161 aacatgcttt gcaccgaatg tttttatatc atctctaaat tttactttta tattttaaca 3746221 taagtccaaa tcgcaagtaa aatgacgcta atgtttcatg tgaaacatga aaaaggaaaa 3746281 gacattcttt gaaaagaatg cccatcacaa ttaatgttta tcatccataa agccagaaga 3746341 ttccttgttt ttctttttcg tttttctgac atacataaaa attaagatca ccagtaaaag 3746401 ggttgttgct tgcagaacgc cgctgctaaa caagaaaaag ttctttatca tgtcccacat 3746461 tgtgtttcac ctctttgtgc atgttctcaa cccgtatcct atataaggtg aatttccctt 3746521 tttaaaaact tcaaaacatc atgaacaaca ttgagcgttg ggcatatgct gatatggaat 3746581 ctgatcgata aaggagaatt ttcacatgga tgaacgcaga acattggctt ggcatgaaac 3746641 attagaaatg cacgagctgg ttgcttttca atcaaacgga ctcattaaac tgaagaaaat 3746701 gataagagaa gtaaaagacc ctcagctcag acagctttat aacgtgtcta ttcagggtgt 3746761 tgagcaaaat ttgagagagc ttcttccgtt ctttccacag gctccgcaca gagaggatga 3746821 ggaagaagaa cgcgcagata acccatttta cagcggtgac ctgctcggtt ttgccaaaac 3746881 atctgtccgc agctatgcca tcgcaattac agaaacagca acacctcaat taagaaacgt 3746941 actggtcaaa cagctgaatg ctgccatcca gctgcacgcc caagtttatc gatacatgta 3747001 tcagcatgga tattatccgt cttacaacct ttctgaactg ttgaaaaacg atgtcagaaa 3747061 cgccaacaga gccatttcaa tgaaataaaa caagcagcaa aggagttccc tttgctgcta 3747121 tttctgctga tccttcacta agccgttcga acgataagat tccagcacgt ctctgttgga 3747181 ttctccccat tctttcattt gcaaaacaat cggttcaagc gtgcgcccaa attccgtcag 3747241 agagtactct accttgggcg gcacctggtg ataaacctca cggtgcacga tgccgtccgc 3747301 ttccagctcc ctcagctgga gagtaagcat tctttgagta atactcgggc agattcgccg 3747361 aaactcatta aatcgtttct tgccatctat catgtgataa aaaagaattc ctttccactt 3747421 tccgccaatg acatctagag tgaattcaac tggacagcct tctttgttcg ggtatatatt 3747481 ctttttttca ctcattcttg accctccaat agtacctttt ttgatactac attacatttt 3747541 gcaactaatc tacccagtat tttacacacc ttttctcctt agctcaaaga aaatgcttct 3747601 tattcacatc aatttttaag ggtttgcatg attacacctg cagcaagacg tgttaaacta 3747661 tataaagatt acactactta aaaaaggata ggagctatca tggaaaagat acttattttc 3747721 ggacaccaaa acccagatac agatacgatt tgttctgcga ttgcttatgc tgatttgaaa 3747781 aacaaactcg gcttcaatgc tgagcctgtc cgcctcggac aagtcaacgg cgaaacacaa 3747841 tacgcgcttg actatttcaa acaagaaagc ccgcgtcttg ttgaaacagc tgcaaacgaa 3747901 gtaaacggcg ttatcctggt tgaccataac gaacgccagc aaagcatcaa agacattgaa 3747961 gaggttcagg ttttagaggt tatcgaccat caccgcatcg ctaactttga aacagctgag 3748021 ccgctttact atcgtgctga gcctgtaggc tgtacggcta ccatcttaaa caaaatgtac 3748081 aaagagaata acgtgaaaat cgagaaagaa attgccggcc ttatgctgtc tgcgatcatt 3748141 tctgattccc tgttatttaa atctccaact tgcacggacc aagacgtagc agcagcaaaa 3748201 gagcttgcgg agatcgctgg agtagatgct gaagaatacg gcttgaacat gttgaaagca 3748261 ggcgctgatc taagcaaaaa aacagtggaa gagctcattt ctcttgatgc gaaagaattt 3748321 acactcggca gcaagaaagt cgaaatcgca caagtaaaca cagtggacat tgaagatgta 3748381 aaaaaacgcc aagctgaatt agaagctgtg atctcaaaag ttgtggctga gaagaatctt 3748441 gatctgttcc ttctcgttat cacagatatc ttagaaaatg attcacttgc tcttgcaatc 3748501 ggtaacgaag cagcgaaagt ggaaaaagcg ttcaacgtta cattagaaaa caacacagcc 3748561 ctcttaaaag gcgttgtttc ccgtaaaaaa caagtcgttc ctgtcttaac agacgcaatg 3748621 gctgaataag caaaaagcat cccgcgtcgg gatgcttttt cttattcacc cagcttctca 3748681 atttgtccca tcacatcagt aatttgcttt gcgttttgga ccaggtctga ctgctccaat 3748741 tctttaagcg ataccttgcc ttcctcggct tgtttcaaca catcttcagc gcttttctgc 3748801 aaggtttcgt tatgctcctg aatggttcga tgaatctccg ctgcggcatc aggcggcgtt 3748861 aattcattaa aatcagcggc agccttctga atcgactcaa gctgcgcttc aagtttttct 3748921 ttcgcctcgg tgtcatttac agctttctca gccaattcag gcgcttcctc tgcaaatgtc 3748981 ttcaccttct ccacataacc agctgcttca ctcgtatagt tcaatccgtc gttcacctga 3749041 tcaagcatgc cgcatccgcc tgcactcaaa agtcccactc cggcaagtac tgtcaaaatg 3749101 atcttcatct tcagccccct catcgtttct ttttcatttt ttcttttaag atcggaatca 3749161 atttctcttt cgctaacggc agccctttcc tcaccaattc acgcttcagc cactttttca 3749221 gcttagacat tctgatgctc ctctcccttt ttgataaaaa tgaaaaaact ccaccaattt 3749281 ggtgaagttc ctgaaacaaa aagaccttca ccaaatcaga tttggcaaag gtctcgctaa 3749341 caatgagatt gccagcaaag ccgaggacac cttgtcccgt aatgacgact ttactgtgaa 3749401 agctactccc ctttggagtg ttcattttta ttactttcat tctaaagcac cgatctgttc 3749461 cagtcaaatt cctgccgttt atataaaagc gcgctgtggt atttaaaatt tgaatggttt 3749521 ttctatcagg agatcatgct atgacagagg aggttttcat catgagtcaa gagcgcgtga 3749581 aacggcctgg gcataccaga tggtacatat cttcgttact tagcggcatt attattctta 3749641 attattttga ccgagtggcc atctcggtag cggcccctgc gatacaagat tcgtttcacc 3749701 ttactgcaac tgaactcggc atcgtgtttt ccatttacac ctattcctat acactgatgc 3749761 agctgcctgt cggaagtttg ctggaccgtt ttggggtcgc atgggtcacg agggttggaa 3749821 tgacaatatg gagcttttta acgatccttc ttgctttttt gcaaggaaaa ttgctgttgt 3749881 atctgttccg gtttctcatt gggctgacga gcgcctctgc gttccctgct gcctctaaag 3749941 caaccgctct ctggtttcct ccaagtgagc ggggattggc aaactcactg ttcgattcgg 3750001 ccgccaagtt ttcaaatgta atcggcgcgc cattggtcgc ctttcttgtc acaacatttg 3750061 actggcgtgt cgcttttttg acgattggat gcatcaatgt gctgtttacg atctttttct 3750121 ggcagtatta tgaacagcct gaacggcaca aacgcatttc taaaagtgaa ctaaactata 3750181 ttcaaaaaca caatgccatt acaacagagc aaatccctta caaaacgggc ccgcttttaa 3750241 aaaagctttt caccaatcga aaagtatggg gcttaatgat cggatttaca gggtacgggt 3750301 atacattcaa cctgctgctc acctggcttc cgactttctt taaacataca tacggtatgg 3750361 atctcatgtc gtccggttta tttacggcag tgccgtggct gatctcaacc atttccggaa 3750421 ttgccgtcgg cggctggctc gtcgattatt ttattaagaa aggctatcct aataccaagg 3750481 tgtaccgaac cgtaatcata gtcggaatga gctttggctt tttcttttta ggatccattc 3750541 tgacgaacaa tattaccgta gccattattt gcatttccat cggactcgcc ggaatttccg 3750601 caaccgctcc ggtcggctgg tccatctccg cagaactcgc gccgatcggt tccgtatcca 3750661 tgctgagctc catggtgaat ctcgcaaaca acctgttcgg aggcattatt gctgcgtcac 3750721 tgacagggta tttgtttgat gtgacaggct cctttaccct cagctttctg gtagctggtt 3750781 ttgtgctgtt gctgggattg gttttttatg tgtttgtatt aggggatgta aaacgaatta 3750841 aactatagaa catgaaaaag agagctgcca gttggcagct ctccctttac atcaaagaat 3750901 cggcccgtcc ccatttacct tctcctcgtc ctgttcctct atatcaagcc ccgaagctag 3750961 catttcctgc tctatctgtt cgagcacctg ctcgtttttt ccttgaagac caccttcata 3751021 atgaaaagca tcctgtgtgc cgttttcctc tattgtcgct aaaatatcgt ggatatcatt 3751081 atggtctcct gaaatggagc cgaatccctg gttttgtttt ttataattca caaaaccgct 3751141 ggggaggttg tttccgaggt ttacacatga tgcgctccga gtagtaattc atcagtgtat 3751201 caaaatcttc attttggatt gccacatcac atgcagagat gatgtctttc aattgctgtt 3751261 ccaaatgaat tcccctaatc atcatgattg gatatattat acaatgtttg acacgtaggg 3751321 atccttttca tttttgtttt tacggtttcg ctggtccatt tccgcagagc tggcgccgat 3751381 cggttccgta tccatgctga gctccatggt aaatctggca aacaacctgt tcgaaggcat 3751441 tattgcggct tcattgacgg ggtattttgt ttgatgtgac aaggctcctt tacgctcagc 3751501 tttctggtag ccagttttgt tctgctgctt ggattggttt tttacgtgtt tgtcttaggg 3751561 gatgtaaaac gaattaagcg ggaataaaga gtgcttgtag agaaaacgtt gttctttcta 3751621 caagcttttt agttttgtgc tgtttttcaa gatattcagc tgtcataaaa agaaaatgag 3751681 ctcccacata ccggctaggt atgtggcgtt cttcttcatg ttctggcatg cagctgtgag 3751741 gaggatttgt ttgctcaccc cctgaacctg cgatagctaa gcccgtgcag ttgttttgaa 3751801 cctacaaagc ttcgttctat tttttctttt ctttttttag agatttcctg aaatagaaaa 3751861 gcaatctttt ctaacctttt ctttatggtt ttgccataca taccgagtaa cgactttctg 3751921 gcgtttcgtt gattttgtgt aatattctca aacatatttc aggatttgat ttatatgacc 3751981 gatagtcttt gcgatcaatt gttgagtacg taagtgtatg ctgattcaac aaatgtatct 3752041 gtattgttca ctttataatg aaatttccat tttggaagca aacccctgac tgggtgataa 3752101 cgtctatgtg cgatggcacc aaaaacttgg aggtcaaata gtcctttaga gatgagagtt 3752161 gttaagtagc cggaatctag agcgacggct tctacttgaa aatcaaatca tgcaatttag 3752221 tgatccaatc ggtcaaggta gggcttggaa cagaatcatg gacttttctg gagttgcaaa 3752281 ctattaatcg tcctcattaa atttataata aaaatattct caattgagca aatcgcccac 3752341 cctttttcct ttataacata aaatccaata ctatcaataa aattctttac aggttattac 3752401 agttaagata taatatagtt aatcttttac gtaaaaggag gtttttatta cttgtgttga 3752461 agttttaaat aggagtaact ccatctcccc attacggtct tcatttaatt tcatcctgag 3752521 ttttatttag ttagatataa aaacgaaaat ttcacattat ttttaactaa ccgatagtat 3752581 aaaatatata ttgaaaggat tgtaaaatta tgaataaatt cctgaagagc aatttccgtt 3752641 tccttcttgc ggctgcttta ggcatatcat tacttgctag tagtaatttt ataaaagcca 3752701 gcaatgataa ctataaattc catttacttg taccttatgg ctatggtaat gcctattcaa 3752761 atgatgcatt tagacagacc actcatacag ataatccttg gaaagtaaat ttacagaaat 3752821 cggcagaagg taaaggtaca atcatgacat tttggttgat taacacaggg aatagtaaaa 3752881 ttccaaaagc ttctaaaata cataacgtaa aacaaggaag cggagctcat tattatcatg 3752941 caaatagcca gggaagccat acatatgtag ccttagcagt tgaaaacaac aattacagtg 3753001 caagttctta tggtatagat ggtgtatggg atgaagaaac ttggtaaaca agaaccttct 3753061 aaaaacgttg gcacctttta gccacgcgaa aaaatttaga atgataatct ttttataaga 3753121 ttatcatttt tatttattct attaagaatt gagtgagaac atggaaagtc atatttatcg 3753181 cattatcaaa aataaattaa ctataataat atttactata atcatattaa ttccttgtgt 3753241 tgatatatca ctattgttaa tgactaacac agaataccat cctgcatatg cgtttttcct 3753301 ttctggcact tccgtagggc atgcttcaca aatgatccta ttatggtttc ttccgcttta 3753361 ttttttgtta ctatgtgctg acgattctat acaagattat aaaacaggat atcattacat 3753421 tcttataagc aaagttggca gaaaaaaata ttgtttggaa aaaatattta cctcttttat 3753481 catttcattt ttgacaatgt ttttgtcact aatattaaac tttttattgg ttcaggtttt 3753541 cttttttaaa ggtacattta aaaatgactt agaccaaatt aaattccctg ataacagcct 3753601 ttatactttt agtatggccc atccttatat agcaattgtg ttattttcta ttatttgttg 3753661 tattatgtct ggatttgttg gagcacttgg ttcaagcctc agtttacttt ttcgtgataa 3753721 gaagtatgcc tacccagcaa gtttttttat ttggttcgta cttatactaa aaaacaaatc 3753781 attaatgttt ttattccaac cgtttacaga atacggttat aatgtacttc tccctatcct 3753841 atgtttgtct atctttattt ttctaataat aatttctagt attgttttat atgaggcaaa 3753901 atacaatgaa aattaaaaga ctactattaa ttttatgttt actactattt ttagttactt 3753961 tatggttcaa ccagaaccac acttatcttg gaaagaattc tatcgcgtca ttactatata 3754021 tgaataatag tacattcgga tatagttcaa tatttgcata taccttgttt tatattgtcc 3754081 cgtttcttat gttacttagt aacttttttc attcagaaaa cccctacaaa gtaatgagga 3754141 tggttaagcg taaaaattac tacaagtcta aaattatgga gattgggttt gtttctttac 3754201 ttttttcttc aatacatact gttattaata ttacgtgtac acatattttc tttagtaaaa 3754261 acttgttggt cgaagcaaac tttttatcaa tttgtttatt aaacatgatt agtttagtgt 3754321 ttttctactt atcagtaggt attatgttta gacttacata cgatctgttt aattcagtag 3754381 cattagcaat ttttattgtg tatataattt tagatagctt gtatttcggc gttaaattat 3754441 tacttcctaa tggatattgg gaacccttta gagacttggc tatattcaca aatatgctca 3754501 atagatattg gtcaacttca aatcttataa tagtttatat tagacagata ataatagttt 3754561 ttatttttta tttagttgga tcttcaattt ttttgaataa ggattataaa aaatgaggat 3754621 taaaggcttt ttcataactt tagttgcgat aatatttcag gcgtcattat cgagttataa 3754681 taataataaa aatgtctttc cttttttaga tggcatacca ataagcacct cgggtcatta 3754741 tgagtatcaa aatattttat tgtggtttgt acctattgtt tccctaagtt tttgtttctc 3754801 tgggagtatt agagatacat acatttcgta tgagcaatta aagttagtaa gagaacatag 3754861 tagagttaaa tgggtaacat ctcaattctt aataattaca gttgtacttt taatctttac 3754921 tttatctcag attgctatat tttatattta ttcacttgta tctcttcata accttgatat 3754981 taattccgtt atcaataaaa gatttgttat gatgacactc atgtattatc taaccttact 3755041 taacttattt agttttcaat tatttatgga gctttattat aaatctcaaa tagcacaatt 3755101 aaatataagc gtttatatta ttttttcgtt aattttagca aagaagttag tgcaattaaa 3755161 ttctccgaaa gttattcact actttttaat tccaaactac agtaatggat taagaactgg 3755221 gttaagctat tattcccaat ctggaactgc tattattgaa ccattattag gtttgtttat 3755281 tataatcatt ttacagattt caatagttat attatctgtc ttaaagttca aaaaaataga 3755341 tatgctaaaa agtgagggct tacaatgatt gaggtattaa acctaacaaa aaaattaaaa 3755401 agactacagt tttagataat atctcttata catttgaaaa aggaacaatt tatggactat 3755461 ttgggagtaa tggttctgga aagaccatgc tacttcgtgc attatccggg ttaatagtcc 3755521 ctactgaagg gagtataact attaaaggtg aacaattaca taaagatatc tcttttccta 3755581 aaagtgtagg attaattata gaaaatatgc agttacttcc tcagtatgat gcttttacta 3755641 accttaaaat tttgtcaaaa attaaaaaga tcgcatcaga taatgatata ttagattcta 3755701 ttagtagagt tggtttggaa aattttaata gtgtaaaggt tagtaaattc tcgttaggaa 3755761 tgaaacaacg attaaatatt gcacaggcta tttttgaaaa acctgatata ttgctacttg 3755821 atgaaccaac aaatgcgatt gatgaaaaag gagttgcatt tgttcatgac attcttttac 3755881 aagagaaaaa aaggggagct accattatta ttactagtca tcacaaggaa gatattatat 3755941 ctttatgtga cattgcatta gaaatgaatc atggacgtct agaaacttca gaaaaagtaa 3756001 tatataagaa agatagttag tttaaactgg ctatttctta tccaatgata gactgcagac 3756061 aagttcaact gctgtaatgc tagaaaatcc aatgaaatgc tgataattgc gaagagatat 3756121 gatcagtcag aaaacaaatc ttaaaaagaa aaagtaaatt catcaatatt tctaataaac 3756181 ctggcaaaca acctgttcgg aggcattata gctacttcac tgacgggata tttatttgat 3756241 gtgacaggct ccttacgctc agctttctgg tgccggtttt gtgttgttgc tgggattggt 3756301 tttttatgtg tttgtattag gggatgtaaa acgaattaaa ctggaataaa gagtgcttgc 3756361 tgaaaagcac tctttttctg catcgaaaga atacttaaga taagtcactc ccaaaaatcg 3756421 taacagtctg acggttaaac ataaacctct gcccgttcca ttttaatacg gtttgaacat 3756481 atcccaatga gtcggcgtta taccttcccg ctatccgctg gtacgccaat aattcgtata 3756541 cgccgtctct gtcaaaatca accggataca agcccgataa aggattcacc catccttcta 3756601 tcggcatttt taacacacct tggctgttat aaatctcatt caaatattcc ctgcccttgt 3756661 aagtaaggtc gaggatatac gtttcgtttt gctgatgact gataacgctc gctttatatt 3756721 gattttgata cctcacactg tactttaatt catcattcaa tacatctgaa ttgaaaattc 3756781 gccggaactg cctgtttaga taggcaaaca catatgcata aatagcaccg ccgcttcccc 3756841 ctgtgtccat tactactgcc acatcctcaa tcttgtcgcc tgtcatatcc cccagaaaaa 3756901 gtgacggatt gtatcccata ttgttttgaa gctgaatccg ctgctcctga tgggttctgc 3756961 catcacggat caccaatgtg atatttctcc ataacgggct gccgggcatt tgatttccag 3757021 ttagaaagac ctcgtcaata acgccgtctc ccgttacatc gccgcgggta gatacaatga 3757081 ttgcacgtga ggagacaggc tgccgaaata cgtatggatg ttgaacaagt cctctgcctt 3757141 cataaaacca ataaggagcc attctgatgt catacacatt caattgtgtc accttcccta 3757201 atcagctgaa tgaatcatta tatgcaggaa tggcacatca aagacatatc ttacacacca 3757261 attaaatccg taccatatga attatcaatt acacaaagcc actcgccttg cgcattcttt 3757321 ttaaatacat aggtcgccct tctttccatc gcatactcgg agtccttttt atccgaatca 3757381 agcagtgtct gagaaagaac gagtaccgtg tcacctgctt ccaacaggat cattttccct 3757441 tgtgtcggga caatatgatg attgaaatag ttcgcaatcg tgataaacgc ttttttgatt 3757501 tcttccttgc ctcgcgcgat catgcccggc ttcacaacta aaacggcatc ttccgaataa 3757561 taattcatca gtgtatcaaa atcttcattt tggattgcca aatcacacgc agagatgatg 3757621 tctttcaatt gctgttccaa atgaattccc ccaatcatca tgattggata tattatacat 3757681 cgctagacca ctgaaacctt gaaaacaaaa tgaaaagtat ccttttttcc tatataatca 3757741 aatagatata tttaacaaag tacccaagtg aaggggtgaa cattattgtc tgcggaagta 3757801 acgttacatg acaatataca ttatgattta agtgcggatt gccagcactg ttttggcctg 3757861 tgctgtgtcg ccttgcctta tgcgaagtcg gcagattttg cttttgataa agacgggggc 3757921 acgccttgcc gcaacttaca atcaaactat caatgttcta tacataaaga tctcagagaa 3757981 aaaggatttc gaggctgctc tgcatatgaa tgctttggcg ccggccaaaa agtatcccaa 3758041 atcacttatg agggaaagga ttggcgaaac agccccgaaa cggccaacca gatgtttgac 3758101 gtttttccta tcatgcagca gctgcacgaa atgctctggt atttacatga agctctttct 3758161 atagatatag ccaagccgat tcattctgaa ctgagaacca ctttcgaaaa aatagaaagg 3758221 ctcaccagac tcagcaaaga acgcttgctg acactgcagg tggacgagca tcgagctgag 3758281 gtcaatgaat ggctgttaaa aacaagtgaa ctggtgcgtg cccaagcccg ccatccaaaa 3758341 ctcccgaaaa aggtcagccg gggaagtgtc ctgatcggcg cgaaactgaa agggcttgat 3758401 ctgcgaggag caaatctaag aggggcgctg ctcatagccg ccgatctgag aaatgccgat 3758461 ttgagaatga cagactttat cggtgcagat atgagagacg ctgatctcag cggcgccgac 3758521 ctgaccggga gcatcttttt gacacaggca caggtgaacg ccgccaacgg cgattcgaat 3758581 acaaagctgc cgctgtctgt acgaacccct gcccattgga aataaaaaag gacccgctaa 3758641 cggtcctttt ttactgatca attcaatcct ttttcgttcc tcttatccgg cattttcaca 3758701 cttcttgcca agtatcccga cagccataac gcaaccagca gcatgaaggt gatcataccg 3758761 acgacgccca gccagtgaaa accagaccag aatagccctc cgattgttcc gaaaacactt 3758821 gaaccggcgt aataaaagaa caaatacagc gatgaagcct gtgctttgtt gtgaagggct 3758881 ctcctgccca cccagctgct ggcaactgaa tgccctccga aaaaaccgaa tgtaaagagg 3758941 gcaatcccca gaattttcac tgccagcata ttgtttatcg taaataacgc acctgcaatg 3759001 acgatgaaaa tattcatcac caatattttc ggatagccat accgatcaac cattcttcca 3759061 atgaaagacg agctgaaaat gcctacaatc atcacaataa agatccagct ggaaaatgct 3759121 ttattaagcg aatacggcgg gcccaacagc acatacacaa tgtaattaaa caaggcaaca 3759181 ttgcttccaa gcagcaaaaa accaatgaga aacaagctga atagtttacg gtccctcaag 3759241 tggccgatca gagacattcc caatttcccg agcttcaatt ttcttggcgt aaaatgcctg 3759301 gatggcggca aatttataaa aaatataaca ctagcaatca aactaatgac accaattgtc 3759361 cccatcgcca tatgccaatt caagtactcg ctcaggagcc cggaaacgat ccttccgaaa 3759421 acggcgccga ttgcatttcc gctgatatat agccccatcg ctgatccaag acttccgggt 3759481 tcaatttctt ccccaagata agccatcgca atcgacggaa ggcctgcgag cgcaacgcct 3759541 tgaatggttc tcaatacgag cagtgtatga aagctcggac taaaggccga tgccagacag 3759601 agaaccgatg cggccagcat ggaaataccc ataataggct tgcgtcccca cacctcggat 3759661 aatgaaccaa agacaagcat gctcacagct aacagcattg tggtaacaga taaagaaaga 3759721 ctcgccgcag taggcgttac atgaaattcc cgcgtgaatt cctccatgag cggctgtacg 3759781 caatatagaa tcgcaaatgt attgaaaccc gcagcgaaga aagcaaacgt aatttttcga 3759841 aaaaccggtg tgccttttcg aatgtatgtc atcgggactt tatcggtccc tcatcatgtt 3759901 gtggagcact gccattcata aacaatcatc ctttatttct tacgaattca aacatcctcg 3759961 agtctgttta tattattatc ttagcaccgt tgatatatgt tgtataatgc atataaaata 3760021 tccttttcat gcttatatgt aataaggaga gatgataatt ggaatgggaa caacttgaat 3760081 attttcaaac actggcccgg atgcagcacg tcacgaaagc cgcaaaaagc ctctccatca 3760141 cacagcctgc actttcacgc tctatcgcca ggctggaaaa tcatttgggc gtcccgctat 3760201 ttgacaggca aggacgatcc atcagcttaa atcaatacgg acacattttt ttacgacggg 3760261 ttcaggcgat gatgaaggag tataccgaag gaaaagaaga aatccaagcc ttattaaagc 3760321 cagaccaagg cgtagtctct ctcggttttt tacatacatt aggcaccacg ctcgtgcccg 3760381 atctcatcgg ctcctttcag caggaatacc ccaacatttc cttccagctg aagcaaaacc 3760441 actcttattg gctgcttgaa cgattaaaat ccggagatct ggacctctgt ctcctcgctt 3760501 cgattaagcc tgaaaatccg atccaatgga tcaagctgtg gagtgaagaa ctctttgtat 3760561 ttgtgccaaa tgatcaccca ttagccagtc gcgaaagcat taccctgaat gagattgccg 3760621 gggagcgttt tattttattg aaaaagggct atgcgcttcg gatgacggtc gatgagctgt 3760681 ttgagaaggc caatatacag ccgaacatta tgtttgaagg agaagaagca actactgccg 3760741 caggttttgt ggcagccggt ctgggcatat ctattctccc agacctgaaa ggcttagacc 3760801 aaagcaaaat caccaaaatc cgcgtcagct ggccggaatg tcagcgtgtc ataggaattg 3760861 cctggataaa aggcaggttt ttatcaccgg ttgctgagac ctttaaacaa tatgtgatca 3760921 gccatttttc tgagtaggaa ggattcaagc atgaatgtca aaaaaatcac gtcagaacag 3760981 gatttacata cagcgtttga aatcagaaag gcagtatttg tagaggaaca aggctgtccc 3761041 atttcggatg aattcgatga gttcgataca ctccacggtg actgccagca catcctggct 3761101 tatcatcaga atgtacctgt tggcactgca cgtgtccgta tcgttggcca cacggggaaa 3761161 ctggaacgaa tctgcattct gaagtcttac cgcaaattcg gtttgggaaa agtgatcgtc 3761221 gatgcattag aacgtattgt aaaagaacaa ggcatttctg ccttcaaact gcacggccag 3761281 acacaggcgg caggctttta tgaaaagctc ggctatcgga ctgcatcaga agaatttatg 3761341 ctggacggca ttccgcatgt gctgatgaca aaacaagacg attctgcgct atagattgtt 3761401 cacaaatttg tcacttatga gcatgaacgg ttcattggta tactaatcac cgattatgga 3761461 gagaaggaat gattgtatgc cagcaaataa aaaagaaggc cttatatttg gcgtgatgat 3761521 gtgctttgga atggtttgcg tcatgtcgat ttacaatgcc atcatcaacc gagccatcta 3761581 cgatttttca ctgatgaccg tttttgaaat ggtcatcggt tttatgatcg ccctcctgtt 3761641 agatttactg ttagtgggcc ccctcgccaa gaagattgca ttccgcatgc cgttcgacaa 3761701 gactaaaaaa atttatgtca tccttgccat gtcaacttgt atggtgattg gcatggtact 3761761 ttgtatgtct gtgttcggtt tagtgacagc ggttctagca aatgggctga acggggacag 3761821 cctcttcagt gcttatctta tgattgtgtt gaaaaatttc atcctggcct atccgttgca 3761881 attactgatt atgggcccat tagtcagagg agttttcatg aaatttgtaa aaccaaagct 3761941 cacagccgca atttaaatag aaaaggagtg agcctgacac tcactccttt tgctcatgaa 3762001 tcgaatgtaa aacaagctcc gcaaaagcct ctgcggcagg cagctgccat tttttctttt 3762061 tgggtgtgag taaatcggat cgagggcttc accatgctgg agatttttca gcttatgttt 3762121 ttcacttcca ttaatcccta taccttacca catagttttt atacaattct tcgttataaa 3762181 ggatttcttc gccatgtgaa gagcaaatga gcgttggttt gatttgatct atgattgagc 3762241 cgctgtcgat gttctcattt atatcaacac tgaatcttct tataggtggg tgtaaatcct 3762301 ccttacttgt gataaaaagg tcgcccgtca atagcgtacg atcgatttta tgataataca 3762361 caacatgccc cggcgaatgg ccaggtgtta aatagtattt cagaggcaga tgagcaagcg 3762421 tttgctccgt cagcggctgt acaatatggg ctacccctgt gttctccact tcatttttgt 3762481 tcggatatgg ctcttcccca ttgatgtact ttagttcttt ctggtgcgca aaaatcggaa 3762541 tatcaaatct ctctaaccat tttgatgcac ccccgatatg atcactgtgg ccatgggtaa 3762601 gcaaaatggc ttttggattg ccgatcgcta acgctgccct aatttgagca tcagcaaaac 3762661 gttctattcc cgtatcaaca atataaacat catcaccatc tttgataaac caggtatgaa 3762721 ccggaatacg aagaggcaca tcaagctcaa attcacattg aaagacatgt tctgatagtt 3762781 gtctcaaatt cacgcaaacc atctcctgtg gaaatttttt gatagtttta aagaaaacag 3762841 aagtgaacgg actattttca cccacgctcg agctgactgg attcttgaga ggaaacgccg 3762901 attttcgcca gcatcagctc aacttgttaa cgttgtccat taataatccc ttttgttccc 3762961 cttcttcaca tattcccaat cacgttctat attcttcctc actctatgaa ggagtgcaga 3763021 aatggtttcc ttttcctctg aagtaaaacc ggacaaggcc acttccgtgg aatgttctcc 3763081 ttctcttctt aacaatggat ataccttttt ccctttctca gtcgggaaca gtttttttat 3763141 ttttttattt tgctcatccg gcagtttttg aataaatccc tgcatttcca gcttcttaat 3763201 ggcccgcgcg gccgttgtcc ggtccacttt tatcatttcc gccaattttt cttgaataat 3763261 tcccggattt tcgtatatac gcacgagata gagatactgc cctcttgtta agtctaaatc 3763321 tttaaattcg atgttgctta tggaatccaa cgctcttgct atcatgccga tctcacgcaa 3763381 aatatcattc attcctaaaa cccctcacgt atttttgttg caattacaac aaaaatgttt 3763441 taaccttact attataagac cacatgcgtg ctgtacagtc cagactaata tcagaaaagg 3763501 attgattcat aatgaatata aaaagaataa caactgaagc tgatttacat gaagctttaa 3763561 agattagaag aggcgttttc attgaggagc aacatgtgtc tgaagccgat gagttcgatg 3763621 aatttgatac gcttcaggaa caatgccagc atatcttggt atatcatgag aatcagcctg 3763681 tcggcaccgg acgcgcgcgc atcgttggcc atacagcaaa gctggaaaga atctgcatcc 3763741 taaaacctta ccgtaagtac ggattgggga agatcatcgt aagcgggtta gaggaaatca 3763801 tgaaagaaaa aggactgact tcatataagc tgcatggtca aacacaagcg gcaggctttt 3763861 atcaaaaact gggctaccag atttcttcac aggaatttat ggaggacggc atccctcacg 3763921 tcttgatgac aaaagaaata tcgcggaata taacatgaaa tatatgtatt acggaatagg 3763981 catactcata ttaagtttgg gcatttcctt aaccatacaa tcaggactgg gcacatcacc 3764041 cttcgatgcc cttttggttg gtctgtcaaa aaaaatcggt cttaccgtag gaagctggga 3764101 ggtccttatt tctgtgatcc tcttaatctg caacgctata ttaacgagaa aaaaacctat 3764161 tttgctgggc ttgattacag cattcattac tggaataggc attgacctat ggttgtttgt 3764221 tgtaaaaaac accatctatc taaactcgtt gttaagcaaa ctgatttgtt ttggaattgg 3764281 tttggtgctc atcggtcttg gaacagccat ctatcttcag acgaaattcg catcaacacc 3764341 gatcgatcat ttaacactta ttatccgaga tctctccaaa agaacaatat tgttttcaag 3764401 gacattggta tacgctcttt tcttagtatt agccatcatc tttaaaggcc ctatcggcat 3764461 cggaactctt ttaacggttt gtttgggagg aatgctcctt cacgttttta tgcctattgt 3764521 ggaaagacat ttcttatcaa agaatagaag aggttattaa gaaacctctt ctcgatccaa 3764581 aaaacgaaac gcaaaacaag ccccgtttcg ttgtcaattc tttatctctg gtactgttga 3764641 ggttttataa tcaattaaaa tttatagtac caaaaaatcg caatttcatt tgctgttgga 3764701 aagttggaat aaagcatcgt atcaaccgca cctattataa agtgatgttt ggcataaaaa 3764761 tgacaagctg aaatattaat atcttgggtt tcaagcataa gaccacaaaa atgattctcc 3764821 tttgcccact caatcgcttt atgtaataat gctgttccaa cacctttttt tctatagtct 3764881 tttgccacgg caatgtcctc tattagtgca tacccattcc agttagaacg gatcttaatc 3764941 cggccaatgc agttgttttc aagataatat aaaaaagccg ctttcccctc ttcttcaaca 3765001 taactaacat ccatgtcatc atcttcatat tgtttaaaat aaggtttaga aaatcgttcc 3765061 tcagtatatg tccaaacacc gttttcaaaa gcaggtatca ttctcccaaa aacaacgaaa 3765121 ggttcgtttg gtttattgaa atctttcata ttcaaatgag tcattttcat gatcatatca 3765181 atctccgcca atcgagataa tatttagtaa actcgtttcg atactattca acaacagctt 3765241 ccaaaagtgt actctttaag agaacagcat tagataaggc atccattacc ttatatattt 3765301 cactatctta atgaggtatt tcaacagagg cttgtggtac agtaaaaagg aatagaaaca 3765361 agagaaaaga agatgaacct atgcccacta acaataaact caatgagaaa tatcatactt 3765421 ccttcaactc gcccacaacc ctgttgacta gtatccgtgg agagaggaag ctttgacaca 3765481 gcttctgcca ttgatgacat ctctattgaa gtatccaaag gacaaccaag gatcgctctt 3765541 tgactttttc aagaagaaag tagagtgaat aaaggagtga ttgagtatgt taacaagaga 3765601 agatatcttt aaacacgtca aagaaaaata cggtacatcg cctgattacc cgtgggagaa 3765661 atacccaaac tatgcttctt tgagacatac atcaaacaaa aaatggtacg gtcttatcat 3765721 gaatgttctc ccagaaaaat taggcttgga tggtcatggc gaaatagata ttctaaatct 3765781 aaaatgtccc cctgaaataa gtgatcgctt aagaaacggg gaaaatatct tacccggata 3765841 tcatatggat aaggaacatt ggatttcaat tgttttagaa cggacagatc cagaaggcga 3765901 aatctataac ttaatcgagc agagctttca tttaaccaag tgaagataaa gagtgttcct 3765961 gctaatcaag ctgcgaagag tagtgggcac tttcatttta ggatactgtt cttcactctg 3766021 tccacaaacg caacttagtt catctggtgc gagagtggga gaagaatttc aaccaacttc 3766081 ttatgtaaaa ggatgaatag ttatgacaaa taacttaaaa cagagaagaa tcattttaga 3766141 tttagcagtt actttagatg gttttattga agggaaaaat ggagaagttg attggtgtat 3766201 tatggaccct gatatggggt ttactgattt tttaaatcaa attgatacta ttttatatgg 3766261 tagaaaaagc ttcgatttat ggggacaata cattccaaaa aatgaagacc ctgatacaga 3766321 aaaggaactt tggaaattgg ttcatagtaa aaagaaatat gttttttcca gaacacaaaa 3766381 tgagattgat aatcaagcca tatttataaa tgataatatt cttgaagaag taaataaatt 3766441 gaagaaaaat cctggtaaag acatctggct atatggtgga gcgagtctca ttacaacttt 3766501 tataaatttg gggcttgttg atgaatttag attatctatt caccctgttg ttttgggaga 3766561 aggaaaaccg ttgtttattg atgtaaaaca gaggataaat ttaaaaatgg tgaatacaag 3766621 aacattttcc tctggcgttg tgcaaatcgt ttatcattgg aatggctaac attgtaaagt 3766681 aacactcgac agtaatcctt cttattgaac taaaggggaa tccataaata atgggttccc 3766741 cttaatatac tatggaatta tcaatatcaa attttctgta ataaaagagg attgaaaagg 3766801 acgatgtctc ctcaattaac atcattaagc attatagtat attttcttct ccctctttta 3766861 agtaatcggc taagttttgt atttataaaa aaacgaaaga aggtgatcca atgcctacta 3766921 acaataaacc caatagatta atcgctgaga aatctactta ttttacttca acatgctcat 3766981 aaccctgtgg actggttccc ttggggagaa gaagcatatg aaaaagcgaa acgcgaaaac 3767041 aagcctgttc tcgtatctat tgggtatagc taacgatggc taatctaaag aacatgctat 3767101 tgatgccatg tttattcatt ttacaaaaaa ggatcaacct tgaattactt tcacaagatt 3767161 gatcctttca ctcatttagc catgtctccg cgaacgttta tatacattca agattactag 3767221 ccaacaaata acaatgattc ctgcaaaaag tatgagcata ttgctataca aataggtaga 3767281 gtgatcaacg tcaataggca gcagcctatg atctaggaag ccgatagata ataaaccgcc 3767341 tacaatcgca atacccgttc cctctgataa aaagctcgtg aaattaagca aactcattcc 3767401 agcgcccgct tccttttctt tcaaactgct agacacaact gtagatataa ctgtttttgt 3767461 gaaagatagc cccccaaaaa caaaaattac tataattgtc atgatccatg gtgctgcatc 3767521 tataaaaaag gcagcgatta aaaagccgga agaaagcaat gcacttccaa tagttagtac 3767581 atacaaggaa cctttccgat caacaagcaa tcccccaatg taaccaaaga tgatgacact 3767641 cattgttccg gggaaaataa tgccgcttcc aattgctgca gtacttaaat ggtgaacatc 3767701 tttcatcatg taaggaacca tagagacaaa tcctgctact gtaccaaata ttagtcctcc 3767761 gcaaagggtt ccaatcacaa aaaagacgtt tttccctaat tcagggtcaa caaaagggtc 3767821 ctgagctttc ctaatgtgtt gcacaaatat gaagaaagca aggatactga tgatcagaaa 3767881 agaaaatcta taagatgttg taaacagcat aaaaaatacg atacctgcag acatcaatat 3767941 aatccctgcc atatcaatgt gtcctcttat tctctcttcc tttttcaaca attttataag 3768001 gaatggaacg gtgataattg ttgcagttgg aataagcagc aaatacgacc aatggatata 3768061 atgagcaacc attccgccaa tagctggccc aacaccttct cccattgcta ccagggaccc 3768121 gatcaggcca aatgctttcc ccctgttctc ttttggaata tagcgcgcaa cgacaaccat 3768181 cacaagagct gggaatgcgg ctgcaccaat tccttgaata aatcgggcta gaatgagaat 3768241 aggaaagaaa gagtgtccaa caaatccaat gatcgaccct aagccattta ccataatccc 3768301 aaatagaagc agatttttga tgcccagctg gtctgatagc tttccatata gagctgttcc 3768361 aatggagaag gttaacataa aggctgtatt cacccagttt gcacttgctg gcagtttatt 3768421 aaactcgttg gcaatatcag gtaatgagac gttcagaacc atttcattta atacgctgaa 3768481 aaatgataga acacaaagcc aaatcaaaac ttgattgtgc cgtaaagttg actgtgaata 3768541 agacgtattc acaatttccc ctccattaat gagggcagac gcagtttata gggtcattga 3768601 tacgcttccc tcttttaatt gtaccctgtt cattttattg cacttcataa taactccccc 3768661 tacatttgat tgatatgatc ttattatata tagactaagg attaaacttt tacttttttt 3768721 ataaaaattt gaccagattg cgaaacaagg aaaaacgtta ttcgcattta tctcaagtgg 3768781 caaaatgaaa cattagttta tattttcaca tcacaattat cgataagcag tcagttattg 3768841 tatttgttta ggataactgt ggtaacctga atataaccaa cttaggaaga aggtgatccc 3768901 atgccaaata aaagtaaacc caatagatta atcgctgaaa agtctcctta tttactccaa 3768961 cacgcccaca accctgtgga ctggttcccg tggggagaag aagcatttgc aaaagcaaaa 3769021 cgcgaaaaca agccggttct ggtcagcatc ggttattcga cgacttgtca ttggtggcct 3769081 gggataatca aatcgtgtgg aactccatta aaagataaca gaagccattt taaacgataa 3769141 tactatttgt tcaaacaata cagtctacct tttatttcat tcattttcta aaacctgtaa 3769201 tccgtaacca cgcggtagca ggttttttta tttgcttgac ttagagttaa ctctaaattg 3769261 taaactaact ttaattaaat gagagggatg atgttgttgt attccattag taaagctgct 3769321 gagaagacta gtattagttc gtatacatta agatattacg aaaagattgg gttacttcca 3769381 ccaccaaaac gaaaaaacag tggaaggcgt ttttatacgg agactgatat tcagttcatg 3769441 ttattcctga aaagtttaaa ggaaacaggt atgtctttgg aggatattaa tgagtttgtc 3769501 aaagacggat gcattttgga aaaaatcaat tcggatgtta aatcggcaca actctcccca 3769561 tctataaata aacgtattga gattttaacc aagcacttag agaaaatgga aattaaaaaa 3769621 agggagctgg aagaagtgat ttctactaca aaaggaaaac tggatacata ttattcaatt 3769681 ttgaaagagg aagtggaaaa caaatgaaac atttaaatat atacataatg ttacttggct 3769741 tctctatttt cacgggagct acttttaatc ttgcaaaata tacagttgga tatttttctc 3769801 catcgtcttc tgcggcatgg cgtttcggtt tagcggctgc agtgatgctc atcattttga 3769861 tttttactga aggtataaag aagagtcaat tacggaaaaa cgccgtttca tacattgttc 3769921 ttggaattat aggaatcttt ggatttaatg ccttgttttt tgttggttta aaatatacat 3769981 ctcccgttaa cggagcatta ataatggggc tgaatccttt attaacagca attctcgctc 3770041 gaattatctt aaaggacaac atgacaaaaa aacaagtact cggcatattc tttgcattca 3770101 tcggtgtatt gttagtcatt acacaaggtt ctatcgaaac cattaaaacc ttatcaattt 3770161 caggaggaga cttaataatc tttacaggta acgtttgttg ggcactttat ggcgtacttg 3770221 gacgtcggtt tgtaaaggat ggtacaccgc tatctacaac cacttatacg atggttattg 3770281 gtgctgttag tttaatagta gtttccttat ttacatccaa acctgtttct ttatcgaaca 3770341 tcccgattgg agtttggggg gcaattgctt ttatggcttt ttttacaagt gttttgggtt 3770401 acctatggtg gaatcagggg attaaagaga ttggagctag taaaacatct ttatttttca 3770461 accttgttcc cgttgtaacg atgattattt catttgccgt tggaacacca ataaaggtat 3770521 ttcaagttat tggggctgtg ctagttatat taggcgtttt aaccgcttcg ggggtaatac 3770581 gtattcctaa gtacaatact aaagaacagt cagctatata aagaaatagg gagtattttt 3770641 gagaaaatgt gttaagttaa atatacacta attataggaa gaaggtgatc ccatgccaaa 3770701 caaaagtaaa cccaatagat taatcaatga gaaatcacca tatttactcc aacacgccca 3770761 caaccctgtg gactggttcc cgtggggaga agaagctttt gaaaaagcaa aacgcgaaaa 3770821 caagccggtt ctggtcagca tcggttattc gacttgtcat tggtgccacg tgatggccca 3770881 cgaaagcttt gaagacgaag aaatcgcgcg tcttctcaat gaacggtttg tggcgattaa 3770941 agtcgaccgg gaagagcggc ctgatgtgga ttctgtttat atgagaatct gccagctgat 3771001 gaccgggcag ggcggctggc cgctgaatgt gtttatcacg cctgatcaaa agccgtttta 3771061 cgcgggtaca tattttccaa agacgagcaa attcaatcgt cccggttttg ttgatgtgct 3771121 tgagcatctg tctgagacgt ttgcgaacga ccgcgagcat gtcgaggata ttgcggagaa 3771181 cgccgctaaa catttgcaga ccaaaacagc tgcaaaaact ggtgagggcc ttagcgaatc 3771241 agcgattcac cggacattcc agcagcttgc cagcgggttt gacacgatct acggcggttt 3771301 cgggcaggca ccgaaatttc caatgcctca tatgctgatg tatttgctac gttatgatca 3771361 caatacaggg caggagaacg ctctatacaa cgtgacgaaa acattggaca gcatggcgaa 3771421 tggcggcatt tacgatcata tcggctatgg gttcgcccgc tattcgaccg atgacgagtg 3771481 gctcgttccc cactttgaaa aaatgctgta cgacaatgcg ctgctgctga ccgcttatac 3771541 agaagcctat caggtcacgc aaaacagccg ctataaagag atttgtgagc agatcattac 3771601 gttcattcag agggaaatga ctcatgaaga cggaagcttt ttctcggctt tggacgcgga 3771661 cacagaagga gaagaaggaa agtactacgt gtggtcaaag gaagagattc taaaaacgct 3771721 cggggacgat ctcggaacgc tgtattgcca agtgtatgac atcactgaag aaggaaactt 3771781 tgaaggcaaa aatattccta acctcattca cacaaagcga gaacaaatca aagaggatgc 3771841 cgggttaacc gaaaaagagc tcagtctcaa actcgaagac gcaagacagc agctcttgaa 3771901 gacacgcgag gaaagaacct atccgcatgt cgatgataaa gtgcttacct catggaacgc 3771961 gctgatgatc gcgggtcttg cgaaagcggc aaaggtatac caggagccga aatatctcag 3772021 cctagcgaaa gacgccatca catttattga aaacaaatta atcatcgacg gccgtgtgat 3772081 ggtccgatat cgtgatggcg aagtgaaaaa caaaggcttt atcgacgatt acgcttttct 3772141 cctatgggct tatctggatc tctatgaagc ttcgtttgat ctttcttatt tacaaaaagc 3772201 gaagaaactg acagacgata tgatcagctt attttgggat gaggagcatg gcggattcta 3772261 cttcaccgga cacgatgcag aagccttaat cgtacgggaa aaagaagtgt acgacggcgc 3772321 cgtgccttca ggaaacagtg tggcagctgt tcagctgctg cgtctcgggc aagtcacagg 3772381 cgacttatca ctgatcgaaa aagcggaaac aatgttttcc gtgttcaagc cagacataga 3772441 agcgtatccg agcggccatg ctttctttat gcaaagtgtg ttaaggcatc tgatgcctaa 3772501 aaaagaaatc gtgatttttg gcagcgcaga cgatccagcc agaaaacaaa ttatagcgga 3772561 gcttcaaaaa gcctttaagc ccaacgactc cattctggtg gcagagcagc ccgagcaatg 3772621 caaagacatt gcgccatttg cagcagacta ccgcatcata gacggcaaaa caaccgttta 3772681 tatttgtgaa aacttcgcct gccagcaacc gacaacaaat attgaagaag cgatccacac 3772741 attaataagc agcagggatt aagacccttg ctgcttactt tttgatttct tatggtacca 3772801 taaagcgatc cccgcaaaca caaggttgac cgctatcgta aagaaagcct cccacatcgg 3772861 gttcccccgc gtaacggtaa acagagaagg aattcctcca tacacactgt ttttttctgt 3772921 aataaacata cacaaaaaca tattattcgc ggcatgggcg ccaagtgata tttcgatgct 3772981 cccagtttta atcgtgtaat acgtccacac aaacccaaat gttaagtact caattcctgc 3773041 ccagacagcg ccattgttca tttctggatt cgcaaaatgc aatacgccaa acaatcctcc 3773101 gacaatcagt gtcaaaaata gaggattttt cgtcaatctc ccgaaagctt gaagcaaaaa 3773161 tcccctgaaa aatagttcct cagctgatgt ctgaatcgga accaaaatga gggcagccgc 3773221 tagcagccag ataaatcgtg atgcattaaa ctcttgcatt gaatagctat caggatgaat 3773281 cacaaaatca atcaattgta cggcgatcat tagcaagaaa taagcaataa aaccaaagga 3773341 aattctccgc caattcatct ttgaatttgg tgttatcacc gttcggaaag gccgcttcaa 3773401 aataaagcgc acagccagcc aaactcccgg aatggcgaat aaataaatca catgggacaa 3773461 ataaagatct acgaggggat cactcagcac agcttcatcc aaatcaaacg tgatattggg 3773521 attcacaata accgtgaaca atatagcgaa aaggtaagct atattcccta atacatataa 3773581 ccctaccatc accaaaaaag cgaaaaaata tctccacaac gtattgtttc cttctatagg 3773641 acggataaat gaattcattc cttctatgtc tcttcctttc aatgagaata ttactatata 3773701 tttgcataaa ttggtctatg aatctactgt tttggaaatc ttttaagcaa aattaaaata 3773761 taaagtgtga atttagttct tccatctagt gatttgaact ctgttgccaa tgaaccaaga 3773821 tacttataat agtcccaaga ggggaatttt cagtcttttc tactactcaa aagggggttt 3773881 tttatgaata cgatcttcaa acaaaagaat acacatcctt tctcaaacgc agcgaatcgt 3773941 ttagaccgcc ttccgatttc acgcgttcat ttccaagtgt taaccgctct cggcattgtt 3774001 tatttctttg atctcgcaga tttatttacc ctcagcaacg tagcgccggc actgatcgag 3774061 cattggggca tcccgctttc aactattgct aacgtaacgg ccgcttcgtt tttaggcatg 3774121 tttttaggcg cttcactggg cggacggctg tccgatcgaa tcggccgcaa aaaagcctta 3774181 aatctatttg tctttgtttt ctcaatcgca tcgctatgca atgctgcggc atgggacatt 3774241 ccatctttaa tgacattccg tttcctcacc ggatttggcg ttgcagccgc catggtcatt 3774301 acgaatagct atttggcgga atttttccct tcaagtgtac gtggaaaata tatttctttt 3774361 tgtgccatga ttggattgat tggggttccg atcaccaaca ttgtgtctgc ctttgtcatt 3774421 cctcttggtt catggggatg gaggctagta tttgtatggg gtgccgtcgg ccttatttat 3774481 tttttcttca tccaccgtct ggaagagtca cctcgctggc acgaaaatcg cggggaatat 3774541 gcgaaagccg atgcgatcct cacccgaatt gaagaacagg ttgaaaagga gaaaggcccg 3774601 cttccggcag catcccagcc taaagtaagc gaaactgtta agcagaatgc aggttacgca 3774661 ggcttattga aaggcagaaa cctcaaaatt accatcgtat tatctgctgt atggattttt 3774721 gaaacgtttg ggttttacgg atttgcttca tgggttccaa gcctgctaaa aagcaatggc 3774781 gtaaccatgg aaaatacatt atggtataac gtattgcatt ccgtcggcgc tccacttggc 3774841 gcactgctcg gctccatgat ttccgaaaga tttcaaagaa aatggatttt agctgcgagt 3774901 gcgtttctga cggccatcgc cgggctctta tatggtatga cttttattcc catcatgatc 3774961 attgtatttg gttttatcgt gaatatcaca gaacgggtct ttacctcgaa cttatacgcc 3775021 tatacatctg aaccttatcc gactgaatac cgctcgtctg gcagcggttt agcctatggt 3775081 cttggccgtt tttcaaacat ttttggctca ttgcttgtcg gatttattgc cgttcagctc 3775141 ggctatatca gcgtcttctt atttattggg ggctgttggc tcgcatgctc cttgctgtta 3775201 atcttcttcg gtcctaatac gaatgcaaaa cagatttaaa aaagtcagtg cggatctgcc 3775261 gcactgatct cattacaatt gcttcaaaat ccttgcgggg tttccgccta caacagtatt 3775321 agcgggtaca tccttagtga caacagatcc agaagcaatc actgcgttat caccgattgt 3775381 cactcccggg ttaatcaccg cccggcctcc aatccaaact tgatctccaa ttgtcacagg 3775441 cttaccgaac tccttcccgg atttcctttc gatcggatca agaggatgac cggccgtgta 3775501 gatatgtaca cctggcgcaa tcaaacaatg acagccgata cgcacctcac acacatctaa 3775561 aatgacacag tcaaaattaa caaatgtatg atctccgata tgaatgtgat agccataatc 3775621 acagcggaat gtcggcaaaa tcgtgacttg atccccaacc gaaccgagca gctccttcaa 3775681 aagcttcgtc cgcactgcat catcttccgg tgtttcgttg tattgtctaa tcagctgtct 3775741 cgcatgcttg cgttctagta atagttgttg atcttccgaa ttgtataatt ctccggctgc 3775801 cattttttct ttttctgtcc tcagcattta agtcactcca gatgtcagat tgtaatctcg 3775861 atcaaatttc cttcatcatc ctcaatcacg ctttcatagt agccgtctcc tgttgtcctc 3775921 gggccgttta ctactgcgaa accatccgcc ttcaatcgat cagtcagttc gtcaactttc 3775981 tcccggctcc caacggaaaa ggcaatatgt gcccagcctg tcattgtttg tgagggcgga 3776041 tcggtcacat tccctttttt cataatttcc agccttgctc cggaatcaaa cgtaataaaa 3776101 taagacttaa aatctttttt ctcattatga tacaaatcat tcgcttcgcc attaaaatac 3776161 gattcataaa aagacttcat tcgctctaaa tcattgaccc agaccgctgt atgttcaatc 3776221 tgcatttctt cctcctcctt cgccttcaat gaagttataa ggtatgaaat gcatttcagt 3776281 tcaagctttt ttcttaaatt tatgctgaat tttgatatca gcgggttcat cctgcaaaaa 3776341 tagagaaaat gctgcgatgc cgagctgctc aagattcaaa tcaagcgacg gaaaaccaag 3776401 aacacggctg atagaagtat ttccctcgcc tatgatttca acatcccaat tattcttttt 3776461 ggcaaataga tgaattccag ctgccacttc atcactattt gcataaatag cagtcggaac 3776521 ccgcccgctc atataaaaat gttcagctgc cagctcacca tcattcatat cgttgcatcc 3776581 ggacagcata tggcggtctt ccaaccttcc gcagacagct ttataggccg cagctttatc 3776641 agccgtgctc gggctcctat cagcttctct gacacacgta aaagcaatat tctcatgccc 3776701 gcggctcttt aaatagcgaa agctctctgc ataagcagtt tttctgtcat taaaagcaca 3776761 agggacatca atgtctccgg tatcctcaca agcgatgacc ggcccatatt cctgataagc 3776821 taaaatgctg tcccaatgat tggcgcggga agtaatgatg agaccgtcta ttttcttcgt 3776881 tcttaacagc tctaaatatt tgatttcaat atcggggtta taattggtgg ggagaagggt 3776941 cgttgcatac tcatgctgaa aagccgcctt ggtgattccg ttaacgattt tatcaaagca 3777001 gggatgatcg ctataaggca gaatcacacc gaccgtatgg gttttcccgc gaatgagatc 3777061 gattgcggtt cgatttggtg tataatccaa ttccttcatg acttgatgaa caagctttct 3777121 cttttcttca gatacatacg gatgatgatt caatacacgc gagacagtcg aaacagatac 3777181 atttgccagt cttgcgatct cttttatatt tgccatctct ttctcctttt catataaaaa 3777241 aagcagtaag tgtaaaatcc ttactgctat ctcatcatat attgatgata agttcaacag 3777301 gacaatggtc ggaacccatg acgtccgctg atatgctggc atcttcaatc tgttccttaa 3777361 ggctttcaga aacaacaaaa taatcaatcc gccatccaat atttctgtcc cgggcgccgg 3777421 cacgatacga ccaccaggaa taagcgcctt caagatcagg ataaacatga cgaaaagaat 3777481 caacaaagcc agcttctaag aaacgagtga atgcctctct ttcttgatct gaaaatccag 3777541 cgttattccg gttcgccttt ggatttttca agtcaatctc ctgatgggct acattcaaat 3777601 caccgcataa aatcactggt tttttctgat ccaattcaag aatataagac agtaaagcct 3777661 cttcccattg catgcggtaa tcaatccgct ctaatcccct tctggaattg ggcgtgtaaa 3777721 cagtcatcac aaacacgttt tcaaattcca gcgtaatcac tctgccttct tggtcatgct 3777781 cttctactcc gataccgtag atgacctgca gcggttcttg cttagaaaaa acagctgtgc 3777841 cggaatatcc ttttttcact gcataattcc agtacacatg atagtcttca ggctggagat 3777901 caacctggcc gtcctgtatc ttcgtttcct gaagacatat aatatctgca tcctcttctt 3777961 tcaaataaga gaggaaatcc atttttctca tcacagcccg caggccgttt acattccatg 3778021 aaatcaactt catgtttcat cctcccccct ataaaaaaga gcaagaaccc gaaggtcctt 3778081 gctctttaca tatcagctta ctcaccgctt acgtatggaa gtaaagccat ttgacgtgcg 3778141 cgtttgatcg ctgcagtcaa tttacgttgg tatttagcgt ttgttccagt tacacgacgt 3778201 ggtaaaattt taccgcgctc agaaacaaac tttttaagaa gatctacatc tttgtagtcg 3778261 atgtgcgtga taccgttaga agtgaaataa cacactttac ggcgtttcgc acgaccgcct 3778321 ctgcgtcctc ctgccattgt catttccctc ctttcttttt cattttaggc gataatcaca 3778381 ttagaatgga agatcatcat ccgagatgtc aatcggtttg ccgtcgttgg caaatgggtc 3778441 atcattaaag ctgttcccct gattgcgtct ctggttgttt tgatttcccc caaatggatt 3778501 atcattttgg cctccgccaa agtactggcc tccgccgctg tttccttcgt tgtatccacc 3778561 tgaaccagaa ccgccgccgt ttttcggctc aagaaattga acactttcag cttggacctc 3778621 tgtcacgaag acacgctgtc cttgctggtt ttcatagttt cttgtttgta aacggccatc 3778681 tacgcctgca aggcttcctt ttttcaagaa gtttgcaacg ttttcggctt gtcttctcca 3778741 agtgacacaa ttaatgaaat cggcctcacg ttctccggac tggttcgtaa atgtacgatt 3778801 cacagcaaga gtaaacgtag caacagccgc accgtttggc gtataacgaa gctctgggtc 3778861 ttttgtcagt cttccgacta atacaactcg gttaagcata agaaagacca ccttttacca 3778921 ttatatattt caaaattgct tattcttctt ctttaacaac aatgtggcga atgatatcgt 3778981 cactgatctt agctagacgg tcaaattctt gaactgccgc agcgtcagat tgaacgttta 3779041 cgatttggta gaaaccgtcg cggaaatcgt tgatttcgta agcaagacga cgtttacccc 3779101 aatcctttgt tccagtgatc tccgcaccgt tagaagtcag aacgttgttg aaacgctcga 3779161 taactgcttt tttagactct tcgtcaatgt ttgggcggat aatgtacata acttcgtact 3779221 ttctcatctg tttgcacctc cttttggact aagcggccca taatgggcaa ggagcaataa 3779281 ttctattact cacaatttta tattatacca aagctcttgt ccctttacaa ctgcatccta 3779341 tacattaaat cggaaatgaa taacatctcc gtcttggacc acatattctt tcccttcaag 3779401 gcggactttt cctgcctctt tagctcctgc cataccgccg cccgcaagaa gatcctcata 3779461 agcaactgtc tcagcacgaa tgaagccccg ctcaaagtca ctatgaataa ttcctgcaca 3779521 ctcaggggct ttcatgcctt ttttgaatgt ccaagctctg acttcctgtt ctccggctgt 3779581 gaaatatgtt gcgaggccga gaagagagta agacgctttg atcagctgat caagacctga 3779641 ttcttgaatg cccagctctt ccaagaacat ttgcttttct tcgccttcaa gctcagcgat 3779701 ttcagattcg atttttgcac acacaacgat aacttctgcg ttttcgccgg cagcgtactc 3779761 gcgaatcttc gctacatttt cattgccaga tggatcagca acttcatctt cacttacgtt 3779821 ggccacgtac aaaataggct tcgaagtcag taaatggagc tgcttcacaa gcttttgctg 3779881 ctcttcagtg aattctacag atcgagcagg cttttcactc tcaaacgctt ctttcagttt 3779941 agataaaatc tcaaactcaa atacagcgtc tttatctttt tgcttcgcaa gcttgctgac 3780001 gcgtgtaatc cgcttttcaa ctgtttccat atcagcgagg atcagctcaa ggttgatcgt 3780061 ttcaatgtca tcaatcggat caacctttcc ggaaacgtgt gtaatgttgt catcggaaaa 3780121 agcacggaca acgtggcaaa tcgcgtcaac ttggcgaata tgagatagga acttgttgcc 3780181 gagtccttct cctttagatg cgccctttac aatccctgca atatcagtga attcaaaagc 3780241 agtcggcaca gtcttcttcg ggttgaccag ctcagtcagc ttttgcagac gatcatccgg 3780301 cacctctaca attcccacgt tcggatcaat tgtacagaac gggtagttgg ctgattcggc 3780361 accggcctgt gtaattgcgt taaatagtgt tgattttccg acgttcggca aaccaacaat 3780421 tccagctgtt aaagccattc tttcatctcc tctatataaa accgtcattg tatgaacgta 3780481 ttttgaacct agagcaatta taaggaggtt cactggaaaa gacaagctga caaaaaagca 3780541 ttttcagctt gccaatccct ttgattatgc ttttttcaag cctactaaac agtcaaaaag 3780601 cgtacttccc attccattat cagaatttgt atcatttgtc agtgcattga ctgaccctcc 3780661 aaaagccgcc cacatgcctt catctatatt aatcgtcttc gcatgagcct gcttcatcac 3780721 tttcaccttg cccttcatgc ttccgcggtc attaaagatg acaacttcgt ctccatcctg 3780781 aagatcctgc ccagccgcta tatctggaga aatatcgacc tgaacgtgct gaagcttttc 3780841 aataaacggc acatgctgtg aatgattgga acgctgcgga tgaatggata agagcgtata 3780901 agggtacttt ccagctaact cctcattatg gaaaacagat tcttcgggca catttaattg 3780961 aagcgagccg ctaaatcctt tttgctcagc tagcgacgaa gtaaattcaa attttccact 3781021 cggcgtcaaa aactgataat catcccacgg cacctgtttt actggaagag ggaggtggcc 3781081 tttttctttt aaacgctcaa gtgtcacatc ctctgcttcc aatgaagaaa gccccatctc 3781141 taaaaattct tgagtgctgt attcaaacag ctcgccaaac ccaagacgtt ttgcaagctc 3781201 tgaccagatc cagctgtccg atttcgcttc accctgcggc tccacaagct tcttcccgta 3781261 ctgaacataa tgatgataca tactggaata gtagatatct tcttcttcaa aaacagtggc 3781321 agtcggcaaa acataatcac acagctctgc ggtatccgtc ataatggaat caatcgcgac 3781381 cgtcattgga accttttcaa atgcttgtct caccttattt gtattcggca cctgagtcag 3781441 cggatttccg cacgtcacaa taatcatctc aatcgcagga tcagcagcgg tcaacacttc 3781501 ttcagcctgt gtcatcattg aaaaagaacg ggatgttgtt tttaattccg gcagcgtcag 3781561 ctttgttttt gcaaagctct caccaatctg gacatttccg aaattcgcgc cgccgccctt 3781621 aattccgaca tttccgcttg ccgccacaag tgcatcaatc caacgaatcg ttcccccgcc 3781681 gtttttatat cgctgcatgc caagccccat aaaagtagac accggaccat cagcatacaa 3781741 acctgccaaa tactccagct cctccataga agtttctgtt ttcacaataa actcttccag 3781801 agaaacggtc ttcaaaagct ctttcacatc atcaaaaccg acagaatgct cagaaataaa 3781861 cgtttcatcc gttcttccca tctcaatcag aaccttcaaa acggctgccg caagccagcc 3781921 gtccattcca ggctttacag agatatagcg gtcggcaagc ttagcagtcg ggttgaagat 3781981 cggatcaatc accgtaatcg tggcgccctt ctttttcacc tgctgcaagt gatggtataa 3782041 gtgcatattt gttcttgata catttcttcc ccacacaaca acatgcttgc tgttgtaaat 3782101 atcaagcggt ccgtgaccgt acgaacggcc aaaatcccag ctttgcgcct cgataccgga 3782161 gccccagcat atgcttccga cgatttcggt cacgccgcca tatccattaa aaaaacgctg 3782221 atcaagcgct tttaacagac cgttattcgc ataatcatgg ctgtgcaaaa cagcagtcgt 3782281 ctccgacgtt tccttgattt cccgaagttt atcggcaatt tcatcaagtg cctgctccca 3782341 agaaatccgc acaaactcgc cattttgttt tttcattgga tagcgaagcc gatcaggcga 3782401 atttgttttt gtctcaagca ttctgccgcg gccgcagatt ttaccttccg taatcggatg 3782461 gtttggatct ccgtccactt ttgttacctt tccatcatca acagtcacca aaaagccgca 3782521 gctgtcccaa caattcagcg gacatgccga ctgatgcact ttgctcatcg ccgtcttctc 3782581 cttaccttct atatgaaaaa gcatgagtgt cggcctattt atgaagtagg ctcctcatgc 3782641 ttgactagta ctttttttag ttttctttca aattctcttc tcggaatcat aacactgtga 3782701 gagcatccct cacacttaat tcgaatatcc attcccatgc gtataatttt ccagctgttc 3782761 gctccgcatg gatgcggttt tttcatttct acgatatcat tcaggccaaa gtctttatcc 3782821 gccaagaccc ttcacctctt ttcctaaact gctgtatcta ttgtacaaaa aaactgatca 3782881 taagagcaat caagataccc gaaaagaaat acatcctctt atttccattt actcaaaata 3782941 ggatataaga gcagacaaac taacaaatac aaattgagca tcccatatat cggatacaag 3783001 aacgcgatca aatcagaaaa tccgaaagaa gtaaaaggta ccattaacac taacaaaatc 3783061 aacacaatca tccatctcgg catatgaata aacgccatca gccggctgga caaacccagc 3783121 aaaccagcta ccgtcgtcgt gtaaatcgcc aggcacagca ccgccgtcat acataaaaaa 3783181 aggaaataag gcgcaccctc cagaacggca aacagcggta tttcaaactg agaaagggag 3783241 cccgccagct ccaccaacgt ttcattataa acaaatgaga tcacgccaaa aataagaccg 3783301 cttgccacac ttgcgatttt tgcttctccg agccctttca tctctttccc aacagaggat 3783361 aaaatcgcaa caactgaaag gatgtttaaa gaggtaaacg taatgctcgc aggccagtta 3783421 tactgctggg acaaatcaat cgtccacgta tggtgatgtg tgctctgaaa ggagatcagc 3783481 gcatataaaa gccccgctac taacacagga atcaaaatac tatttataga taatattcct 3783541 ttcacatccc acaaaaacaa gcacactgtc acgatgcaaa tcagcgtgat tccccaccag 3783601 aaaggaagct tgtacatttg cagggtcaca ccgcctccgg caatcatcac catagtcgtc 3783661 gaaaacaaat aaaaaatgat gaggacatca taaattttcg ccagccatgg ccccattaaa 3783721 tgctccagaa ccggcagaaa atgagtggat tgaaccttaa aactgatttt catcacaata 3783781 taagacgaga aaatgaacat aattgtaaac agcacaatag caagtccgct ttccgcccca 3783841 aaaaactgcc atatctcctg accgctcgca tatccggccc cgatcaggct ccctaatatg 3783901 agcagcatcc acttcattcc ggctctccac aacactatca cctcatagac aaagttcagc 3783961 ttgttcccgt tattgttact atataaataa aggaaagcaa acatgccata ttttcataga 3784021 catttgaaca caagctgaaa ttatcatacg aaatacacat aaaaaagact gctaatacgg 3784081 cagtctaaaa agagatattt atttgtttgt ccgcggaatg aagaagtgaa cttcactctt 3784141 cacttttttc taaccattcc tacctattca agtgtttcat aagcagacca ttgcttgatc 3784201 atgatcgagg caatggggga caatacttgt aatcgcccac taaccattca tatcatgccc 3784261 tctacttttt taaaatctct ggtgccatac acaaagcata aaaaatcata ctgctggata 3784321 tactgtaaac aaccttacat aactacacac accatagcaa ttctgttacc tactataaca 3784381 aggaagtgaa acccatgaat cgaaaaggcg ggcttttttc ttctcaggaa cgagtaaagc 3784441 aatatgtttc acatacagat gctgcagcgg caaaacaaat ccaaaccatc ctttcttcat 3784501 ccttacgtaa agctgctggc aaaccaattg tcgtggtttg tatcggaaca gaccgttcaa 3784561 ccggtgactc attaggcccg ctcgtaggaa tgaaactcaa acagatgcag ctcaccagat 3784621 tccatgtcta cggaacctta tctgaccccg tccatgctgt gaacatgaag gataaaatca 3784681 atgacattca taaattacat aaaaacccat ttgttatagc agtcgatgca tgcttaggcc 3784741 gcgttaagag tgtgggttca tttcaaatcg gggacgggcc attaaagccc ggagccggtg 3784801 tacaaaaaga ccttcctgaa gtgggagatc ttcatattaa cggaatcgtg aatgtgagcg 3784861 gttttatgga atattttgta ttgcaaaata ctagactcaa cttggtcatg aatatggcaa 3784921 atgttctagc ggaaggtttg agtttaacag atcggacaga gtggaggcaa gaacgcctta 3784981 acccgttgca aaggctcact gggcgcatat aaaataaaaa ccatcttcgt ttgaaagatg 3785041 gttttttcat ttatgattct cgttcagaca aaagctctaa aatccggtca aggtcttcat 3785101 tagagaaaaa ttcaatttcg attttgcctt ttttcttctg tcttttaata ttaactgttg 3785161 ttccaaaata attttggaga taggattccc gttcttttag aaccgcatct ttcacaggtt 3785221 cttttttctt tgtttcacgt ggaacattct gattcaactg ctgaatcagc tgctcaagtt 3785281 ggcgaacatt gagctgctcc gcaatcactt tttgtaccag cggttcaagc ttatttttgt 3785341 tttttaagcc aagaagcgtg cgtccatgtc ccatagaaag cgtgccttcg gcaataagct 3785401 gttgaatatt ttctggcagt gtcagcagtc ttaaatgatt cgcaatatgc ggtctgcttt 3785461 tcccaagacg tttggcaagc tgctcttgtg tgagatctaa gtgtttcaaa agggagtcat 3785521 atgcctgagc ctcttcaagc ggagataaat cttcacgctg aaggttttct aataaagcaa 3785581 tttccctcat taacgcctct gataattcac ggacaatggc cggaactgta tctaaacctg 3785641 ccagctttgc cgctcgaaaa cgccgttcac ccgcaacaat atcatagcct tttaaagatt 3785701 ttctgacgat aagcggctga agaatgccat gctgcagcac agattctttt agttcagcta 3785761 atgcctcgtc atcaaagtgt tttcttggct gataaggatt agggcgtaaa tcggcaattt 3785821 taatttcttc aactgtctct tcagacaaat ctacctgatt aaataacgca ttaatccctt 3785881 ttccaaggcc tttagccatt cgcagccact tcctttgcta aatctaaata tacttccgca 3785941 cctcttgacc gcggatcgta taaaatgatg ggttttccgt gactcggtgc ctcactcaga 3786001 cggacattac gcggaataac tgtcttatat actttatccc taaaatactt tttaacctct 3786061 tcaatcactt gaatgccaag gtttgtccgg gcatcaagca ttgtcagcaa tacaccttca 3786121 atcattaaat cagtattcaa atgcttttgc acaagacgta ctgtatttaa taactggctg 3786181 agaccctcca aggcataata ttcgcactgt acaggaatca caacggaatc cgaggcagta 3786241 agggcattaa tcgtcagcaa gcccaatgac ggcggacaat caatgataat ataatcataa 3786301 ttttgcttta ctgcttcaag cgctctcttc aatctcactt ctcttgatat tgtaggaacc 3786361 agctcgatct cagcccctgc aagctgaatc gtcgcaggaa tcacatccaa gttctctact 3786421 gtcgttgctt taataatatc tattacatct gcatcatcta ctaaaatatc gtacacacac 3786481 tgctctacat cggctttttc aatccctaat ccgcttgtcg catttccctg cggatcaata 3786541 tctaccagca gaaccctttt ccctatgtaa gccaaacatg ccccaaggtt gacagacgtc 3786601 gttgttttgc cgaccccgcc tttttggttc gtaattgcta tgatttttcc cacgatgtca 3786661 cctactttca catgaacatg tactatcttg cttctattct atcaaaaaaa gattaaagcg 3786721 tttcattttt ttcatcattt tgttccgaat cagaagggaa ataattgaaa attcaagcac 3786781 gctttatgct ttctcttata aattctgcaa tttctatgtt tttttgactt aaaaaaggaa 3786841 tttcttaaag aaaaaaagaa gaagtcacag tacagaacgt ggaaacagga tggtgagaaa 3786901 atggtttatc aaacgaagag agatgtaccc gttacgctga tgattgtgtt tctcatatta 3786961 ctgatacaag cagatgccat tgttcctttt gtgctgggaa atatgagagt ttccggctgg 3787021 atcattttta ttctgctgac tcttttaaat ggactcatca tttggagctt tattgaccta 3787081 aaatatgtat tgaaggaaca ccatctgatc attaaagccg gattgatcaa acatcaaatt 3787141 ccttatgaaa acatcgataa agtcgttcaa aaaaagaaac tatggtccgg ttttcgtctg 3787201 atcggctctc gccatgccat cacaatatat tatcaggggg gatggggaca tgcagtaatt 3787261 tcaccgcaaa aatctgaaga atttatccac aagctcaaag aaaagaattc taatataata 3787321 atattcacta aaagtaagtg attacctttt gttaaaaata taaaaagctc tcctgctttt 3787381 caggagagct tctattttgg tatgcgaatc gttaattgaa tatattcttc aaattcttct 3787441 tcttccgtat tcaattttac accgctgtct tccaccattg atagtgactg gcgaatcgtg 3787501 ttcatcgcaa ttcttgtatc tctgctgaat gctttgcgtc tcggctttgg ctttctctgg 3787561 ccttgctcca gcattttcac cacgcggtct tctgtctgct ttacatttaa acttttctca 3787621 ataatctctg tgagcagtgt gacttggagc tcaggctgtt tcagcggaat cagtgctctg 3787681 gcatggcgct cggtgatttt cttctccata atcgcctctt ggaccggctg aggcagcttt 3787741 aataaccgaa gcttattcgc gattgtagac tgcccttttc ctaagcgctg tgcgagtgcc 3787801 tcctgtgtta aatcatgcag ctcaagcagc ctagcataag catgcgcttc ctcaatagaa 3787861 gacagttctt cccgctgcaa gttttcgatt aacgccacag aagcggtttc cgtgtcggaa 3787921 aaatccttaa taattgccgg aatcttttcc cactcaagcg attgcaccgc tctccagcgt 3787981 ctttcacctg caatgagttc gtattggcct tcttcttctg tatgcctaac aacaatcggc 3788041 tgaataatgc cgtgtgtatg aatggtcatt gctaactctt tgattttttc atctgagaaa 3788101 atggtgcgtg gctgaaaacg gttgggaacg atagcattta ccggtatttc cagaatctct 3788161 tctttgtttg tatcatgttc agcaatctcc ggctcctgtt ccttctcacc aagcccgaag 3788221 aaacgagaga atgaatgctt catgtaccta caccaccttt aaaaactgcc atttttataa 3788281 ttctattttc tcatggtttt tcctgctgta catccatcaa ttttgatgaa aatatgatgg 3788341 tattgtcata tcaggctgtc taaattaccc ttcaattggc gatttattag gagttcccgg 3788401 ttttcttgga tacttcttag gtgtattttt tattttgcgt atcaccataa tattacgatc 3788461 gctttcttca ataggcagct taaaagaatg gatattctca agttctcctc caagcgtcgt 3788521 gattgctttt ttgcctgcat tcagttcttc ttcagctgat gcggctttta aagcaacaaa 3788581 taaaccgttt ttcttcacca gaggcaagca aagctcactc aaaacagata atctcgcaac 3788641 tgcgcgcgcc gtcacaatat catagctttc acgcacgtct ttccgttgcc cgaacgtttc 3788701 agctctgtca tggcagaatg ttgtattctc caattgcaaa gcttcagaca acttttctaa 3788761 aaacgtaatc cgtttgttta gtgaatccac gattgtgaca tggaggtgcg gaaagcatat 3788821 ttttatcggc agacttggaa aacccgctcc cgctccaaca tcacaaatcg tgttcacctg 3788881 attgaagtcg acataaaaag cagctgtaat ggaatcataa aaatgcttta aatacacttc 3788941 ttttttctct gttattgaag tcagattgat tttttcgttc cattcaacca gcatgtcgta 3789001 atacagctca aattgctcca gctgacgggg agaaagggag atcccttttt ccgccaaacc 3789061 agaagtgaat tcttcaatat tcatgccgtc atcctttcta ctcggctatc ttcgcaatgc 3789121 gtccctgctc taaatacacc aatagaattg aaatgtccgc cgggtttaca ccggaaatgc 3789181 gggaagcctg ggcaacagac aaaggccgta catttttcag tttttgacgc gcctcggtcg 3789241 caatcccctt aattgcgtca taatcaattc ggtctggaat ttttttattt tccatcttct 3789301 tcagtttttc cacttgctga agagattttt caatatatcc ttcatatttc acttggattt 3789361 ctacttgttc tgccacgtct tgaggaaccg gcacttctgg cggcgccagt tttgtgactg 3789421 tttcatagtt catttcagga cgtttcatca agtctgtgcc gcgaactcca tctttcaatt 3789481 cgcttccgcc aagagaacgg atatattctt gattttccgg agacggcttg ataattacag 3789541 aatgaagacg ttttttctcc gcctcgatcg ccgctttttt cttctcaaaa gccgcatagc 3789601 gctcatcaga aatcaatcca atgcgatgtc cgatttctgt cagacgcaaa tcagcattgt 3789661 catggcgaag cagcaatctg tattccgcac gtgatgtcaa aagacgatat ggctcattgg 3789721 taccttttgt cacaaggtca tcaatcagaa caccaatata ggcgtcagaa cggcttagaa 3789781 ttacttcttc ttttccaagc gcttttcgtc ctgcattgat tcccgccata atcccttgtc 3789841 ccgcagcttc ttcataaccg gatgttccgt taatttggcc tgcagtataa aggtttgtga 3789901 tttttttggt ttcaagtgtc ggccatagct gtgtcggtac gattgcatca tactcgatcg 3789961 catagccggc tctcatcatt tgcacgtttt caagtccagg aatcgttgca agcattcttt 3790021 gctgtacgtc ttctggaaga cttgtagata aaccttggac atagacttcc tgtgtatttc 3790081 tgccttccgg ctcaaggaag atttggtgac gcggtttatc attaaaacgg acaactttgt 3790141 cttcaatgga tgggcagtat cttgggcccg tacctttgat cataccggaa tacatcggtg 3790201 aacggtgcag gttgctgtca ataatctcat gtgtctcagg gcttgtatat gtcagccagc 3790261 aagggagctg atctgtgata tattccactg tttcatatga gaaagcgcga ggcacatcgt 3790321 caccaggctg aatttccgtt ttgctgtaat caatcgtgtc gcttttaacg cgaggcggcg 3790381 tacctgtttt aaaacgaaca aggtcaaaac cgagttcctc caaatgctca gaaagcttaa 3790441 tagaaggctg ctggttattc gggccgcttg agtaagacag atcgccaaga atgatacgtc 3790501 ctcttaaata tgtccctgtc gtcatgacaa ctgctttcgc acgataatgt gcgcctgttt 3790561 gtgtaataac gcctcggcat tcgccgtctt caacgatcag ccgctccaca attccttgca 3790621 gcaatgttaa gtttggttct ttttcaagcg tatttttcat ttcgtgctga tattggaatt 3790681 tgtctgcttg cgcacgcaat gcacgaaccg caggaccttt tcctgtattc agcattctca 3790741 tttgaatatg tgttttatcg atgtttcttc ccatttctcc gccgagcgcg tcaatttcgc 3790801 ggacgacaat cccttttgcg gggccgccga cagacggatt acatggcata aatgcaacca 3790861 tatctaggtt gatggtcaag acaagcgttt tggcgccttg gcgtgcagat gcgagggcag 3790921 cctcaacacc ggcatgcccg gcgccaatca caatcacatc gtattggcct gcttcatacc 3790981 ccatgattct agttcctcct ttaattattt tcctaaacag aattgagaaa agagctgatc 3791041 aattaagctt tcgtggacag aatctccaat gatttcccct aaaagctccc agcatcttgt 3791101 aaggtcaatt tgcaccatgt cgatcgggac atcctgttcg atgccgctaa gcgcatcttc 3791161 aatggcgcgt tttgcttgct gtaaaatagt gatgtgacgt gtgttgctga cataagtcag 3791221 atcaccgctt tcaatggcac ccgtgtagaa cagtgattga atcgcttctt ccagatcatt 3791281 gatgccttcc tcttttaaaa gagatgtcgt aacaactgga cgtccattgg caagctcacg 3791341 gacacgttca gtgtcaatct tcggctcaag gtcagtctta ttcaaaatca cgataacatc 3791401 catgccctca acggcttcaa aaagcttcac gtcttcttca gaaagctctt cactataatt 3791461 aagcacaagt aaaatcaggt ccgcttcctt taggacctgg cgagaacgtt caacaccgat 3791521 tcgctcaaca atatcctctg tttcacgaat acctgctgta tcaaccagac gaagcggaac 3791581 gccccttaca ttcacgtatt cctcaatcac atcccgtgtc gttccgggaa tatcggttac 3791641 aatggctttt gcctcatgaa cgaggctgtt cagaagagat gattttccta cgtttggccg 3791701 gccgataatg acggtagaaa gaccttcacg caagattttt ccttgctcag aagtcctcag 3791761 cagcgtctca atttcctttt tcacggcggt tgccttttcg actaaaatct gatgcgtcat 3791821 ttcctctaca tcatcatact ccggataatc aatattcacc tcaacatggg ccagtgtttc 3791881 taaaatctca ctgcgcaaac ggcgcaccaa agcagaaaga cgcccttcca tttgattcat 3791941 agcaacgttc attgcccggt ccgttttcgc tctgattaag tccataaccg cttccgcctg 3792001 tgaaagatcg attcggccgt ttaaaaacgc acgtttcgta aattcaccag gctctgccag 3792061 tctcgctccc tctctcaatg caagctgaag cacttggttc acagtcacaa ttcccccgtg 3792121 acagttaatc tcgatgacat cttctcgtgt aaaagttctc ggcgctttta acactgatac 3792181 cattacttcc tcaacgacac gatccgaagg tctgtctacg atatgaccat aatgaatcgt 3792241 atgtgattcg accgagctga gtgttttccc cttcggtccc ttataaattt tatctgcgat 3792301 ttgaatggct tctggtccgc tcaaccgtac aatcgcaatc gcgccttctc ccatcggtgt 3792361 ggaaattgcc gcaattgtat ccatgttgtt cacctctctt tacttatact tcatctatat 3792421 aaaaaaattt ttattatgcc aaaactaaaa gataacatag tttggttcga agtggaagat 3792481 ttgttatcca cagaaataga aattcgtccc ttattacttt aacttatcca catgtgaata 3792541 acaattaatt ttatttcctg aacttccttt ttatcaacag gatacaccta aaaagaaaaa 3792601 acttaaacgg caaaaccttg atattactag gaaaagtaga tttttcggat acaaaaaaac 3792661 cgaaatccaa tttttatcgg acttcggttt tatgctatct tttatgggaa ataacgagat 3792721 gacgattttc gccttcaccc attgaatatg ttttgatctg gtggtttgca tatccagaaa 3792781 gagtatcgtg aataattttt ctttcgctgg acggcatggg ctcaagctgg atggattttt 3792841 tcgttttcaa aacctggtca gcaagcttga tggccagctg gctcagtgtt tcttttcttt 3792901 tcaaacgata gttttctgca tccaccgtca catttttata ttggcctgga taacggttaa 3792961 gggcaagctg tgtcaaagtt tcaagggcgt ttaaagtttg tcctcttttc ccaatcaaca 3793021 atgctgcctt ttcacctgtt atatgatatc tcactgtctt tttgctttct tgaacagtca 3793081 catcagactt cccggcaatg gcttcggcaa tcgtttgaag atataacttc gcttgctgaa 3793141 tcggatcaat cttttcaacc agctttacga tcgcaggctt tttaccgaaa ataccgagaa 3793201 accctttgtt tccctcttca ataacagtaa tttctacctt atccttcgtt aatcccaact 3793261 cttgcaatcc ggactgtact gcttcatcga catttcgccc tgcagcagtc acattcctca 3793321 ctttttcttt cctccggctt tttgcggctc aggatttttt ttaatatcag gtcctttaat 3793381 gaggaaagtt tgcgcaatca taaacaagtt accaactacc caataaagag aaagagccgc 3793441 cgggaagttg atcgcaaata cgataatcat aattggcata atccaaagca tcatcgccat 3793501 ttgcggattt tgctgcgcat tgccagccat catcagtttt tgctgaacaa atgtagcgac 3793561 accggcaacg ataggaagaa tatagtaagg atctttttct cctaagtcaa accataagaa 3793621 gctatgctct gaaatcgcct gggttctcat gatcgcatga tagaatccaa ttaaaatcgg 3793681 catctggatc aaaatcggga aacatcccgc caatggattg acaccatgct tttggaataa 3793741 agccattgtt tcctgttgaa gcttttgctg cgttttttga tcctttgagc tgtatttttc 3793801 tttaagcttt tgcatttccg gctgtaaagc ctgcatcgct ttcgaacttc tcagctgctt 3793861 aatcatcagc ggtaaaatta ataaacgaat taaaatggta actagaataa ttgaaagccc 3793921 gtagttatct cccgtcaatt tcgctacata cgtaatgagc tcagacaatg gatatactac 3793981 gtacttgtcc cagaaatgcg gactatctgc agtgatcggc tctttcacac tcgagcatcc 3794041 agccaaaagc atgaatacgc caaccatact taatagcaac cctattctcc ttttcaacaa 3794101 catttcctcc tataattaat ctttacactc ttttattgca aagcatactt gtatgtattt 3794161 tagcatcttt cagttttaaa tggtgtcttt ttctgatcaa ccagaaagga agcgctttta 3794221 aaagttgtaa gaaagcagtg gtgatgccta ctttgacgaa gatttcttat ataatgaaga 3794281 ctttctgaat agatgctgca gacttttttt cgtttcctca tatgtcagct ggctcgccgg 3794341 ttttctggca ataatgatgt aatccttttc cttcagtctc tctttctctt caagaaaggc 3794401 ctgccgaatc aaacgtttga tccgatttcg catcacagca ttgccaattt ttttgctgac 3794461 ggaaagcccg acacgcagtt catcattttc aggctgatca agcgtatata agacaaactg 3794521 gcggtttgca actgatgtcc catgtttaaa cactttttga aaatcttcat ttttctttaa 3794581 acgatttcgc ttcttcaaat gactcactcc gatactggct ggcagaaact tttaaaattt 3794641 attatgaaca tgagatgcat ctgaaccagg aagcatgccc cggttcatta cgcatcacat 3794701 ctatcttttc ccataacgtg aaaaaagacc actgacatta ttcagtggcc taagctgata 3794761 atacttttct gcctttgcgg cgacggcgtg ctaaaactag acgaccgttt tttgaactca 3794821 tacggcttct gaagccatga actttgctgc gtttacggtt attcggttgg aatgttcttt 3794881 tcatttatga cacctccctc gaggaatagc tgttaaagac agtcttactt attatatttg 3794941 cgttacctat tcattgtcaa cttcactagt gcttttattt cttgcaacca taataggata 3795001 ccataccttt tcaactttcg aaaccttatt ttttagattc cttaatttta cggaaaaaag 3795061 acaaattcaa acaatttgcc cctaaaatca cgcatgtgga tatctttttc ggcttttttt 3795121 agtatccaca gaggttatcg acaacatttt cacattacca acccctgtgg acaaggtttt 3795181 ttcaacaggt tgtccgcttt gtggataaga ttgtgacaac cattgcaagc tctcgtttat 3795241 tttggtatta tatttgtgtt ttaactcttg attactaatc ctacctttcc tctttatcca 3795301 caaagtgtgg ataagttgtg gattgatttc acacagcttg tgtagaaggt tgtccacaag 3795361 ttgtgaaatt tgtcgaaaag ctatttatct actatattat atgttttcaa catttaatgt 3795421 gtacgaatgg taagcgccat ttgctctttt tttgtgttct ataacagaga aagacgccat 3795481 tttctaagaa aaggagggac gtgccggaag //